# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Methyltransf_2 PF00891.18 CCL98008.1 - 8.9e-18 64.4 0.3 3.5e-17 62.4 0.3 1.7 1 1 0 1 1 1 1 O-methyltransferase domain YscK PF06578.12 CCL98008.1 - 0.019 14.5 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) MFS_1 PF07690.16 CCL98009.1 - 2.6e-31 108.8 41.8 8.2e-22 77.6 13.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCL98009.1 - 8.9e-05 21.5 23.2 0.00012 21.1 7.7 2.3 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 CCL98009.1 - 0.00015 20.3 0.6 0.00015 20.3 0.6 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 CCL98009.1 - 0.0089 14.9 2.6 0.0089 14.9 2.6 2.5 2 0 0 2 2 2 2 MFS_1 like family DAO PF01266.24 CCL98010.1 - 1.4e-41 143.3 0.0 1.7e-41 143.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCL98010.1 - 3.3e-09 36.8 0.0 8e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCL98010.1 - 6.3e-06 25.6 0.0 0.0016 17.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCL98010.1 - 0.00023 20.5 0.0 0.00052 19.3 0.0 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 CCL98010.1 - 0.00031 20.1 0.0 0.0021 17.3 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CCL98010.1 - 0.0026 16.9 0.1 0.31 10.1 0.0 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 CCL98010.1 - 0.0036 17.8 0.0 0.25 11.9 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCL98010.1 - 0.0042 16.2 0.0 0.0082 15.3 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCL98010.1 - 0.0072 16.3 0.0 0.95 9.4 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding 3HCDH_N PF02737.18 CCL98010.1 - 0.0089 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MCRA PF06100.11 CCL98010.1 - 0.037 12.8 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 MCRA family AlaDh_PNT_C PF01262.21 CCL98010.1 - 0.16 11.3 0.0 0.35 10.1 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 CCL98010.1 - 0.2 11.3 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 CCL98010.1 - 0.24 11.7 0.0 0.57 10.5 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 CCL98010.1 - 0.24 10.9 0.1 0.44 10.1 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain KCH PF16944.5 CCL98011.1 - 0.1 12.3 1.0 0.15 11.8 1.0 1.2 1 0 0 1 1 1 0 Fungal potassium channel CENP-B_dimeris PF09026.10 CCL98011.1 - 0.17 12.3 4.9 0.39 11.1 4.9 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nop14 PF04147.12 CCL98011.1 - 0.87 7.7 7.7 1.3 7.1 7.7 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2569 PF10754.9 CCL98011.1 - 1.5 9.2 5.7 3.2 8.2 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) GOLD_2 PF13897.6 CCL98011.1 - 1.9 9.0 4.8 5.3 7.5 4.8 1.7 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking SDA1 PF05285.12 CCL98011.1 - 2.8 7.3 10.6 0.091 12.2 4.6 1.6 2 0 0 2 2 2 0 SDA1 NOA36 PF06524.12 CCL98011.1 - 3.4 6.9 7.2 5.9 6.1 7.2 1.3 1 0 0 1 1 1 0 NOA36 protein Methyltransf_2 PF00891.18 CCL98013.1 - 1.4e-27 96.4 0.0 3.9e-27 94.9 0.0 1.7 1 1 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CCL98013.1 - 0.00042 20.2 0.0 0.0023 17.9 0.0 2.1 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_25 PF13649.6 CCL98013.1 - 0.0035 18.0 0.0 0.013 16.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCL98013.1 - 0.0057 16.5 0.0 0.02 14.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCL98013.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Glyco_transf_15 PF01793.16 CCL98014.1 - 6e-123 410.2 5.1 7.1e-123 410.0 5.1 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Hydrolase_2 PF07486.12 CCL98014.1 - 0.052 14.4 0.2 0.11 13.4 0.2 1.5 1 0 0 1 1 1 0 Cell Wall Hydrolase DUF751 PF05421.11 CCL98014.1 - 0.14 12.9 2.1 0.34 11.7 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF751) SMP PF04927.12 CCL98016.1 - 0.015 15.8 0.3 0.025 15.1 0.3 1.4 1 0 0 1 1 1 0 Seed maturation protein SMP PF04927.12 CCL98017.1 - 0.028 14.9 6.6 0.054 14.0 6.5 1.6 1 1 0 1 1 1 0 Seed maturation protein SET PF00856.28 CCL98018.1 - 3.3e-12 47.1 0.0 3.7e-11 43.7 0.0 2.3 1 1 0 1 1 1 1 SET domain TPR_MalT PF17874.1 CCL98018.1 - 0.071 12.5 0.1 0.1 12.0 0.1 1.2 1 0 0 1 1 1 0 MalT-like TPR region Hexapep_loop PF18776.1 CCL98018.1 - 0.082 12.5 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Hexapeptide repeat including loop TPR_12 PF13424.6 CCL98018.1 - 0.17 12.2 0.1 0.29 11.4 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Glyco_transf_15 PF01793.16 CCL98020.1 - 3.1e-106 355.3 4.9 3.9e-106 355.0 4.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF5560 PF17715.1 CCL98020.1 - 0.1 12.0 0.4 0.17 11.3 0.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5560) Bromodomain PF00439.25 CCL98021.1 - 3.5e-21 75.1 0.0 6.9e-21 74.1 0.0 1.4 1 0 0 1 1 1 1 Bromodomain DCB PF16213.5 CCL98022.1 - 1.6e-53 181.1 0.2 1.6e-53 181.1 0.2 2.0 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 CCL98022.1 - 7.2e-53 178.7 0.2 2.7e-52 176.9 0.2 2.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 CCL98022.1 - 2e-35 122.2 1.8 3.2e-22 78.5 0.6 3.8 3 1 0 3 3 3 3 C-terminal region of Mon2 protein DUF1981 PF09324.10 CCL98022.1 - 1.3e-05 25.0 0.1 0.0013 18.6 0.0 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) Ank_5 PF13857.6 CCL98023.1 - 2.1e-13 50.2 0.5 3.9e-09 36.6 0.4 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCL98023.1 - 1.6e-12 47.6 0.7 1.3e-07 32.0 0.1 2.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCL98023.1 - 1.7e-11 44.5 0.0 2.7e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCL98023.1 - 4.7e-08 32.7 0.0 1.7e-05 24.9 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 CCL98023.1 - 1.2e-07 31.8 0.2 6.2e-06 26.4 0.3 2.6 2 0 0 2 2 2 1 Ankyrin repeat Homeodomain PF00046.29 CCL98024.1 - 4.7e-06 26.4 1.4 1.2e-05 25.1 1.4 1.7 1 0 0 1 1 1 1 Homeodomain DUF1178 PF06676.11 CCL98024.1 - 0.3 11.5 3.3 0.41 11.0 2.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) Acid_PPase PF12689.7 CCL98026.1 - 6.7e-60 201.8 0.0 8e-60 201.5 0.0 1.1 1 0 0 1 1 1 1 Acid Phosphatase RHH_3 PF12651.7 CCL98026.1 - 0.25 11.3 0.4 0.96 9.5 0.0 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix domain DUF1726 PF08351.11 CCL98027.1 - 0.031 14.2 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1726) NAD_binding_4 PF07993.12 CCL98028.1 - 2e-25 89.4 0.0 2.7e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCL98028.1 - 1.1e-07 31.6 0.0 1.9e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCL98028.1 - 0.019 14.1 0.5 2.1 7.4 0.0 2.4 3 0 0 3 3 3 0 RmlD substrate binding domain NAD_binding_4 PF07993.12 CCL98029.1 - 2.8e-30 105.4 0.0 3.5e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCL98029.1 - 1.7e-08 34.2 0.0 2.1e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCL98029.1 - 0.00034 19.8 0.7 0.026 13.6 0.0 2.5 3 0 0 3 3 3 2 RmlD substrate binding domain 3Beta_HSD PF01073.19 CCL98029.1 - 0.12 11.3 0.0 0.29 10.1 0.0 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCL98029.1 - 0.23 10.8 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase MFS_1 PF07690.16 CCL98030.1 - 7.2e-30 104.1 41.8 9.5e-30 103.7 41.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Colicin_im PF03857.13 CCL98030.1 - 0.002 18.1 0.7 0.0052 16.7 0.0 2.0 2 0 0 2 2 2 1 Colicin immunity protein Abhydrolase_6 PF12697.7 CCL98031.1 - 1.8e-18 68.0 2.7 2.1e-18 67.7 2.7 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL98031.1 - 4.6e-14 52.3 0.0 6.3e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCL98031.1 - 1.3e-13 51.2 0.4 1e-11 45.0 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CCL98031.1 - 0.089 12.5 0.0 13 5.5 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family IIGP PF05049.13 CCL98032.1 - 8.8e-20 71.1 0.0 1.2e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 CCL98032.1 - 6.6e-06 26.2 0.0 1.9e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCL98032.1 - 0.00032 20.6 0.0 0.00094 19.1 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase Roc PF08477.13 CCL98032.1 - 0.0073 16.5 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCL98032.1 - 0.032 14.0 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CCL98032.1 - 0.071 13.6 0.1 0.071 13.6 0.1 3.0 2 1 0 2 2 1 0 ABC transporter XRN_M PF17846.1 CCL98032.1 - 0.55 9.1 16.2 1.1 8.2 16.2 1.4 1 0 0 1 1 1 0 Xrn1 helical domain V_ATPase_I PF01496.19 CCL98032.1 - 0.61 7.9 14.2 0.85 7.5 14.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Borrelia_P83 PF05262.11 CCL98032.1 - 1.6 7.2 30.7 2.4 6.6 30.7 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Asp-B-Hydro_N PF05279.11 CCL98032.1 - 1.6 8.7 33.1 3 7.9 33.1 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Z1 PF10593.9 CCL98032.1 - 2.7 7.4 13.2 0.064 12.8 3.2 2.6 2 1 1 3 3 3 0 Z1 domain Dynamin_N PF00350.23 CCL98032.1 - 4.9 7.2 0.0 4.9 7.2 0.0 3.1 2 1 0 2 2 1 0 Dynamin family Sin3a_C PF16879.5 CCL98034.1 - 7.5e-80 268.7 1.2 2.4e-78 263.7 0.0 3.5 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 CCL98034.1 - 4.9e-38 129.1 0.5 1.4e-37 127.6 0.5 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor PAH PF02671.21 CCL98034.1 - 1.6e-30 105.0 1.2 6.5e-19 67.8 0.0 4.4 4 1 0 4 4 4 3 Paired amphipathic helix repeat LRRC37AB_C PF14914.6 CCL98034.1 - 0.17 11.8 0.0 0.17 11.8 0.0 2.4 1 1 1 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain CPSF100_C PF13299.6 CCL98034.1 - 1.2 9.3 7.9 5.8 7.1 7.9 2.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 CCL98034.1 - 7.1 6.3 6.4 31 4.2 6.4 2.1 1 0 0 1 1 1 0 FAM176 family IF4E PF01652.18 CCL98035.1 - 3.8e-52 176.3 0.0 5.3e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF1102 PF06510.11 CCL98035.1 - 0.015 15.5 0.0 0.024 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1102) Med25_SD1 PF11235.8 CCL98036.1 - 0.02 15.2 17.6 0.032 14.6 17.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 25 synapsin 1 WW PF00397.26 CCL98037.1 - 0.0009 19.3 3.5 0.0009 19.3 3.5 2.8 2 0 0 2 2 2 1 WW domain Metallophos PF00149.28 CCL98038.1 - 7.3e-36 124.6 0.0 1.1e-35 124.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 CCL98038.1 - 0.15 11.8 0.5 1.4 8.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) DUF4646 PF15496.6 CCL98039.1 - 1.5e-43 148.3 0.0 2.6e-43 147.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) Apt1 PF10351.9 CCL98039.1 - 0.0062 15.4 1.3 0.0093 14.9 1.3 1.3 1 0 0 1 1 1 1 Golgi-body localisation protein domain YL1 PF05764.13 CCL98039.1 - 0.03 14.4 12.3 0.047 13.8 12.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein NAM-associated PF14303.6 CCL98039.1 - 0.16 12.6 9.9 0.33 11.7 9.9 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain SEEEED PF14797.6 CCL98039.1 - 0.5 10.5 18.2 0.99 9.6 18.2 1.4 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex CDC45 PF02724.14 CCL98039.1 - 0.53 8.5 12.0 0.73 8.1 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 CCL98039.1 - 0.66 9.6 8.8 0.9 9.2 8.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PGA2 PF07543.12 CCL98039.1 - 3.4 7.7 10.8 7 6.6 10.8 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF4646 PF15496.6 CCL98040.1 - 2.7e-40 137.8 0.0 5.7e-40 136.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) PAP2 PF01569.21 CCL98041.1 - 2.6e-19 69.4 6.1 5.8e-19 68.2 6.1 1.6 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 CCL98041.1 - 0.029 14.1 9.5 0.038 13.7 4.2 2.7 2 0 0 2 2 2 0 PAP2 superfamily bZIP_2 PF07716.15 CCL98042.1 - 0.0025 17.9 6.8 0.59 10.3 4.2 2.6 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 CCL98042.1 - 0.054 13.6 9.4 0.62 10.2 5.6 2.6 2 0 0 2 2 2 0 bZIP transcription factor Catalase-rel PF06628.12 CCL98042.1 - 0.089 13.0 0.2 0.98 9.7 0.0 2.4 2 0 0 2 2 2 0 Catalase-related immune-responsive TMF_DNA_bd PF12329.8 CCL98042.1 - 0.15 12.1 0.2 0.15 12.1 0.2 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ATP-grasp_2 PF08442.10 CCL98042.1 - 0.2 11.2 0.8 0.44 10.1 0.8 1.5 1 0 0 1 1 1 0 ATP-grasp domain GST_N_3 PF13417.6 CCL98044.1 - 1.1e-10 41.7 0.1 2e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCL98044.1 - 6.7e-10 39.1 0.0 2e-09 37.6 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CCL98044.1 - 1.9e-06 28.1 0.0 1.4e-05 25.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CCL98044.1 - 0.0019 18.4 0.0 0.0033 17.6 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin MINDY_DUB PF04424.13 CCL98045.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 MINDY deubiquitinase DEAD PF00270.29 CCL98046.1 - 1.1e-15 57.9 0.0 2.2e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCL98046.1 - 7.6e-14 52.0 0.1 1.7e-12 47.7 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CCL98046.1 - 1.4e-10 41.7 0.1 5.3e-10 39.9 0.1 2.1 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 CCL98046.1 - 4.9e-06 26.6 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RQC PF09382.10 CCL98046.1 - 0.041 13.7 0.1 0.14 12.0 0.1 1.8 1 1 0 1 1 1 0 RQC domain Syntaxin_2 PF14523.6 CCL98046.1 - 0.064 13.6 1.0 0.19 12.1 1.0 1.8 1 0 0 1 1 1 0 Syntaxin-like protein Spc7 PF08317.11 CCL98046.1 - 0.069 12.0 0.5 0.12 11.2 0.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Cep57_CLD_2 PF14197.6 CCL98046.1 - 0.45 10.6 3.6 1 9.5 3.6 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 APG6_N PF17675.1 CCL98046.1 - 1.5 9.3 4.7 1.3 9.5 2.7 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region Lebercilin PF15619.6 CCL98046.1 - 6.7 6.3 9.3 4.7 6.8 5.7 2.0 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease CPSF_A PF03178.15 CCL98048.1 - 3.7e-77 259.8 0.0 7.4e-77 258.8 0.0 1.5 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 CCL98048.1 - 1.2e-16 60.4 0.0 3e-16 59.1 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term WD40 PF00400.32 CCL98049.1 - 8.5e-08 32.8 7.9 0.16 12.9 0.0 5.8 7 0 0 7 7 7 3 WD domain, G-beta repeat SRA1 PF07304.11 CCL98049.1 - 1.6e-06 28.0 0.0 1.6e-06 28.0 0.0 3.6 4 0 0 4 4 4 1 Steroid receptor RNA activator (SRA1) Prp18 PF02840.15 CCL98049.1 - 0.026 14.6 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 Prp18 domain Sec16_C PF12931.7 CCL98049.1 - 0.032 13.9 0.3 0.1 12.2 0.0 2.0 2 0 0 2 2 2 0 Sec23-binding domain of Sec16 Sec63 PF02889.16 CCL98051.1 - 1.8e-148 492.7 0.0 7.4e-77 258.0 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CCL98051.1 - 6.5e-46 156.3 0.3 1e-25 90.5 0.2 3.3 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 CCL98051.1 - 3.3e-34 117.4 0.0 9.1e-34 116.0 0.0 1.8 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 CCL98051.1 - 2.2e-24 86.4 0.4 7.2e-16 58.7 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCL98051.1 - 7.5e-10 39.1 0.0 3.4e-08 33.8 0.0 3.7 4 1 0 4 4 4 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CCL98051.1 - 6.5e-07 29.7 0.1 0.02 15.1 0.0 3.2 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 CCL98051.1 - 0.00018 21.1 0.0 0.012 15.1 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.20 CCL98051.1 - 0.0033 16.5 0.0 0.097 11.7 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Helicase_C_2 PF13307.6 CCL98051.1 - 0.0064 16.7 0.4 6.2 7.0 0.0 3.7 3 1 0 3 3 3 1 Helicase C-terminal domain AAA_7 PF12775.7 CCL98051.1 - 0.011 15.3 0.0 3.8 7.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region UDG PF03167.19 CCL98052.1 - 1.3e-16 61.0 0.0 2.7e-16 59.9 0.0 1.7 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily RRM_1 PF00076.22 CCL98053.1 - 5.1e-25 87.1 0.0 3.3e-13 49.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCL98053.1 - 4.8e-13 48.8 0.0 4.6e-08 32.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCL98053.1 - 3.4e-07 30.0 0.0 2.9e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CCL98053.1 - 0.013 15.5 0.1 0.17 12.0 0.0 2.4 2 1 0 2 2 2 0 Limkain b1 Nup35_RRM_2 PF14605.6 CCL98053.1 - 0.036 14.0 0.0 12 5.9 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 CCL98053.1 - 0.7 10.1 4.1 9.6 6.4 0.1 3.4 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Malic_M PF03949.15 CCL98054.1 - 1.6e-81 273.4 0.0 2e-81 273.0 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CCL98054.1 - 6.1e-54 182.6 0.0 8.6e-54 182.1 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain FhuF PF06276.12 CCL98054.1 - 0.0083 16.5 0.1 0.12 12.8 0.1 2.5 3 0 0 3 3 3 1 Ferric iron reductase FhuF-like transporter LysM PF01476.20 CCL98055.1 - 4.8e-10 39.4 0.0 8.2e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 LysM domain MARVEL PF01284.23 CCL98056.1 - 1.5e-08 34.7 23.0 2.6e-08 34.0 23.0 1.4 1 1 0 1 1 1 1 Membrane-associating domain RdRP PF05183.12 CCL98058.1 - 2.2e-106 356.9 0.0 2.9e-106 356.5 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase p450 PF00067.22 CCL98059.1 - 8.1e-26 90.8 0.0 3.2e-25 88.8 0.0 1.7 2 0 0 2 2 2 1 Cytochrome P450 CorA PF01544.18 CCL98060.1 - 3.2e-12 46.4 2.3 1.6e-07 31.0 0.8 2.4 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein FlgT_N PF16548.5 CCL98060.1 - 0.069 13.7 0.1 1.3 9.7 0.0 2.5 1 1 1 2 2 2 0 Flagellar assembly protein T, N-terminal domain Methyltransf_23 PF13489.6 CCL98061.1 - 6e-18 65.2 0.0 8.6e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCL98061.1 - 5.6e-17 62.2 0.1 9.7e-17 61.5 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCL98061.1 - 1.3e-16 60.8 0.0 1.8e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCL98061.1 - 3e-15 56.6 0.0 4.7e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCL98061.1 - 1.2e-13 51.6 0.0 2.2e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCL98061.1 - 8.5e-11 41.6 0.1 6.8e-10 38.7 0.0 1.9 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CCL98061.1 - 8.5e-05 22.2 0.0 0.00015 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 CCL98061.1 - 0.00019 21.4 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCL98061.1 - 0.00041 19.8 0.0 0.00054 19.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Pox_MCEL PF03291.16 CCL98061.1 - 0.00058 19.1 0.0 0.00081 18.6 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme FtsJ PF01728.19 CCL98061.1 - 0.00072 19.7 0.0 0.0015 18.7 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase TehB PF03848.14 CCL98061.1 - 0.00098 18.6 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB tRNA_U5-meth_tr PF05958.11 CCL98061.1 - 0.0015 17.6 0.0 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase NodS PF05401.11 CCL98061.1 - 0.003 17.2 0.0 0.0045 16.6 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) TPMT PF05724.11 CCL98061.1 - 0.029 14.0 0.0 0.041 13.5 0.0 1.4 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) DREV PF05219.12 CCL98061.1 - 0.032 13.3 0.0 0.063 12.4 0.0 1.7 2 1 0 2 2 2 0 DREV methyltransferase Cons_hypoth95 PF03602.15 CCL98061.1 - 0.079 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Sugar_tr PF00083.24 CCL98062.1 - 1.1e-118 397.0 14.7 1.5e-118 396.6 14.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Proteasome PF00227.26 CCL98062.1 - 7.8e-56 188.6 0.1 6.2e-55 185.6 0.1 2.1 2 0 0 2 2 2 1 Proteasome subunit Ribonuc_L-PSP PF01042.21 CCL98062.1 - 4.5e-38 130.0 0.0 8.9e-38 129.0 0.0 1.5 1 0 0 1 1 1 1 Endoribonuclease L-PSP MFS_1 PF07690.16 CCL98062.1 - 1.1e-16 60.7 51.7 3.8e-16 59.0 23.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Proteasome_A_N PF10584.9 CCL98062.1 - 8.9e-12 44.5 0.3 1.1e-10 41.0 0.0 2.5 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature G-alpha PF00503.20 CCL98063.1 - 1.6e-89 300.6 0.0 4.5e-44 151.1 0.7 2.4 2 1 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 CCL98063.1 - 1.2e-07 31.4 0.2 0.018 14.5 0.0 3.2 3 0 0 3 3 3 3 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCL98063.1 - 0.0077 15.6 0.2 3 7.1 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCL98063.1 - 0.038 13.5 0.1 0.4 10.2 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 CCL98063.1 - 0.14 11.9 0.1 0.32 10.8 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DASH_Ask1 PF08655.10 CCL98065.1 - 3.7e-25 87.6 0.1 6.5e-25 86.8 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 Inositol_P PF00459.25 CCL98067.1 - 1.6e-65 221.3 0.0 1.9e-65 221.1 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family p450 PF00067.22 CCL98068.1 - 7.1e-47 160.2 0.0 7.9e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCL98069.1 - 9.5e-52 176.3 0.0 1.2e-51 175.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCL98070.1 - 8.8e-51 173.1 0.0 1.5e-50 172.3 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 MASE1 PF05231.14 CCL98071.1 - 0.3 10.2 15.1 1.4 8.0 15.1 1.8 1 1 0 1 1 1 0 MASE1 Dor1 PF04124.12 CCL98072.1 - 1.5e-60 204.7 2.7 2.6e-60 203.9 2.7 1.4 1 1 0 1 1 1 1 Dor1-like family Vps51 PF08700.11 CCL98072.1 - 7.1e-08 32.4 0.1 2e-07 31.0 0.1 1.8 1 1 0 1 1 1 1 Vps51/Vps67 Med21 PF11221.8 CCL98072.1 - 0.00035 20.8 0.1 0.029 14.6 0.0 3.0 2 1 0 2 2 2 1 Subunit 21 of Mediator complex Baculo_PEP_C PF04513.12 CCL98072.1 - 0.008 16.2 2.3 0.017 15.2 0.8 2.3 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Zw10 PF06248.13 CCL98072.1 - 0.02 13.5 0.1 0.027 13.1 0.1 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 ERAP1_C PF11838.8 CCL98072.1 - 0.044 13.3 0.4 1.8 8.0 0.0 2.4 2 0 0 2 2 2 0 ERAP1-like C-terminal domain Sec5 PF15469.6 CCL98072.1 - 0.048 13.5 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Exocyst complex component Sec5 MscS_porin PF12795.7 CCL98072.1 - 0.27 10.8 2.6 0.56 9.7 2.6 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain COG5 PF10392.9 CCL98072.1 - 0.32 11.2 4.6 0.26 11.5 1.8 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 TRI5 PF06330.11 CCL98073.1 - 7.2e-15 54.7 0.0 9.9e-15 54.3 0.0 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) DUF3591 PF12157.8 CCL98075.1 - 3.6e-176 586.2 0.4 5.7e-176 585.5 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 CCL98075.1 - 0.00014 21.6 2.5 0.00036 20.3 2.5 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CCL98075.1 - 0.79 9.9 3.3 1.5 9.1 3.3 1.4 1 0 0 1 1 1 0 Zinc knuckle PA28_beta PF02252.18 CCL98076.1 - 6.1e-52 175.2 0.7 7.9e-52 174.8 0.7 1.1 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit zf-CCCH_6 PF18585.1 CCL98076.1 - 0.029 14.2 0.1 0.14 12.0 0.0 2.1 1 1 1 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 WD40 PF00400.32 CCL98077.1 - 2.1e-15 56.8 8.3 4.9e-05 24.0 0.1 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 CCL98077.1 - 1.4e-14 54.1 0.1 1e-13 51.3 0.0 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 CCL98077.1 - 0.0001 22.5 0.6 0.081 13.2 0.2 3.2 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain MAPEG PF01124.18 CCL98078.1 - 4.3e-20 71.9 0.5 5.6e-20 71.6 0.5 1.1 1 0 0 1 1 1 1 MAPEG family Transthyretin PF00576.21 CCL98080.1 - 1.4e-33 115.8 0.0 1.7e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Nop52 PF05997.12 CCL98081.1 - 1.6e-73 247.1 0.0 2.4e-73 246.5 0.0 1.3 1 0 0 1 1 1 1 Nucleolar protein,Nop52 MMS19_N PF14500.6 CCL98081.1 - 1.4e-05 24.8 0.0 2.9e-05 23.8 0.0 1.6 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II LRR_3 PF07725.12 CCL98081.1 - 0.66 9.9 2.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Leucine Rich Repeat RabGAP-TBC PF00566.18 CCL98082.1 - 4e-28 98.6 0.0 5.4e-28 98.1 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GCP_C_terminal PF04130.13 CCL98083.1 - 2.2e-29 102.9 0.1 4.3e-29 102.0 0.1 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CCL98083.1 - 1.7e-26 93.6 0.1 4.7e-25 88.9 0.0 2.5 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal Pyrophosphatase PF00719.19 CCL98084.1 - 1.1e-59 200.8 0.1 1.4e-59 200.5 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase I-set PF07679.16 CCL98085.1 - 0.0039 17.2 0.0 0.92 9.6 0.0 4.4 5 0 0 5 5 5 1 Immunoglobulin I-set domain CENP-T_C PF15511.6 CCL98086.1 - 4.4e-07 30.0 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 CCL98086.1 - 6.4e-05 23.1 0.1 9.1e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 CCL98086.1 - 0.00014 22.2 0.0 0.00018 21.8 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CCL98086.1 - 0.00098 19.4 0.1 0.0018 18.5 0.1 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCL98086.1 - 0.0019 18.5 0.2 0.0022 18.4 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CCL98086.1 - 0.061 13.4 0.0 0.07 13.2 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit FAD_binding_3 PF01494.19 CCL98087.1 - 1.3e-24 87.2 1.1 4.1e-23 82.2 1.1 2.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCL98087.1 - 2.9e-05 23.4 1.7 0.00065 19.0 0.4 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCL98087.1 - 9e-05 21.9 0.4 0.16 11.2 0.1 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCL98087.1 - 0.00013 22.2 1.1 0.00013 22.2 1.1 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCL98087.1 - 0.013 14.2 4.6 0.34 9.6 4.1 2.0 2 0 0 2 2 2 0 HI0933-like protein Orbi_VP4 PF05059.12 CCL98087.1 - 0.048 11.7 0.0 0.069 11.2 0.0 1.1 1 0 0 1 1 1 0 Orbivirus VP4 core protein SE PF08491.10 CCL98087.1 - 0.063 12.3 0.0 0.12 11.4 0.0 1.4 2 0 0 2 2 2 0 Squalene epoxidase Pyr_redox PF00070.27 CCL98087.1 - 0.067 13.8 2.6 0.15 12.7 2.3 1.9 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCL98087.1 - 0.07 13.0 0.7 1.1 9.1 0.5 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 CCL98087.1 - 0.085 12.1 1.2 0.17 11.1 1.2 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 CCL98087.1 - 0.17 11.9 2.7 9.4 6.2 0.8 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CCL98087.1 - 0.29 10.4 3.5 0.17 11.1 1.7 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCL98087.1 - 0.62 9.6 3.8 1.4 8.4 3.8 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCL98087.1 - 3.2 6.7 5.8 0.83 8.7 2.7 1.5 2 0 0 2 2 2 0 FAD binding domain FtsX PF02687.21 CCL98088.1 - 0.21 12.1 0.2 0.21 12.1 0.2 3.1 3 2 0 3 3 3 0 FtsX-like permease family Glyco_transf_22 PF03901.17 CCL98089.1 - 9.1e-82 275.5 15.0 1.9e-49 169.0 4.0 2.1 1 1 1 2 2 2 2 Alg9-like mannosyltransferase family TMEM154 PF15102.6 CCL98091.1 - 0.0074 16.2 0.1 0.024 14.6 0.0 1.9 2 0 0 2 2 2 1 TMEM154 protein family DUF4131 PF13567.6 CCL98091.1 - 0.015 14.9 0.1 0.044 13.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Miga PF10265.9 CCL98091.1 - 0.034 13.1 0.6 0.058 12.4 0.6 1.2 1 0 0 1 1 1 0 Mitoguardin Sin3a_C PF16879.5 CCL98092.1 - 1.1e-83 281.3 0.0 6.7e-83 278.7 0.0 2.3 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.21 CCL98092.1 - 6.2e-42 141.5 10.5 1.2e-18 67.0 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 CCL98092.1 - 2.4e-36 123.7 0.0 5e-36 122.7 0.0 1.5 1 0 0 1 1 1 1 Sin3 family co-repressor Zn-C2H2_12 PF18112.1 CCL98092.1 - 0.0064 16.9 0.2 0.017 15.6 0.2 1.7 1 0 0 1 1 1 1 Autophagy receptor zinc finger-C2H2 domain SH3_1 PF00018.28 CCL98093.1 - 4.6e-11 42.2 0.1 8.2e-11 41.3 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCL98093.1 - 1e-09 38.1 0.0 1.8e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCL98093.1 - 2.2e-09 36.8 0.0 4.1e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 CCL98093.1 - 0.014 15.6 0.1 0.027 14.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain PsbT PF01405.17 CCL98093.1 - 2.1 8.2 4.9 17 5.3 0.0 2.8 2 0 0 2 2 2 0 Photosystem II reaction centre T protein zf-C3HC4 PF00097.25 CCL98094.1 - 2.5e-09 36.8 8.3 4.6e-09 36.0 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCL98094.1 - 2.4e-08 33.9 9.0 2.1e-07 30.8 5.4 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCL98094.1 - 2.8e-07 30.8 10.2 4.8e-07 30.0 10.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCL98094.1 - 7.3e-07 28.9 8.7 9e-06 25.4 9.5 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCL98094.1 - 6e-06 26.3 10.1 1e-05 25.6 10.1 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CCL98094.1 - 1.1e-05 25.2 6.2 1.8e-05 24.5 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCL98094.1 - 0.0001 22.2 6.7 0.0002 21.3 6.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCL98094.1 - 0.0028 17.5 7.3 0.0052 16.6 7.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 CCL98094.1 - 0.0087 15.9 6.0 0.018 14.8 6.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 CCL98094.1 - 0.019 15.2 6.8 0.042 14.1 6.2 1.9 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CCL98094.1 - 0.064 13.0 8.4 0.21 11.3 4.2 2.6 2 0 0 2 2 2 0 RING-like zinc finger zf-ANAPC11 PF12861.7 CCL98094.1 - 0.78 9.8 3.0 1.5 9.0 3.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-MIZ PF02891.20 CCL98094.1 - 1.9 8.3 10.3 4.5 7.1 10.4 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Wbp11 PF09429.10 CCL98095.1 - 6.7e-20 71.3 7.4 6.7e-20 71.3 7.4 1.9 2 0 0 2 2 2 1 WW domain binding protein 11 NpwBP PF12622.7 CCL98095.1 - 0.0035 18.1 47.1 0.0035 18.1 47.1 5.7 2 2 0 2 2 2 1 mRNA biogenesis factor Umbravirus_LDM PF04817.12 CCL98095.1 - 0.17 11.2 2.1 4.5 6.6 0.1 2.4 2 0 0 2 2 2 0 Umbravirus long distance movement (LDM) family Spc7 PF08317.11 CCL98095.1 - 4.6 6.0 9.2 8.8 5.1 9.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein LRR_4 PF12799.7 CCL98096.1 - 0.64 10.5 11.4 2.4 8.7 0.0 5.0 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) HIT PF01230.23 CCL98098.1 - 9.8e-25 87.2 0.0 1.3e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CCL98098.1 - 3.9e-06 27.3 0.0 6.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Kdo PF06293.14 CCL98100.1 - 0.00018 20.9 0.1 0.00028 20.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CCL98100.1 - 0.0077 15.6 0.0 0.022 14.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 CCL98100.1 - 0.17 11.4 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Metallophos PF00149.28 CCL98101.1 - 6.2e-14 53.0 1.3 6.2e-14 53.0 1.3 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCL98101.1 - 0.0013 18.9 0.0 0.12 12.5 0.0 2.9 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain RSN1_7TM PF02714.15 CCL98103.1 - 3.6e-07 29.8 22.6 4.9e-07 29.3 19.1 2.2 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_ext PF12621.8 CCL98103.1 - 0.0042 17.2 0.0 0.0093 16.1 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter Sec1 PF00995.23 CCL98104.1 - 2.2e-118 397.0 0.0 2.5e-118 396.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Bax1-I PF01027.20 CCL98105.1 - 7.5e-37 127.2 11.0 7.6e-37 127.2 9.8 1.6 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 WD40 PF00400.32 CCL98106.1 - 4.1e-29 100.2 16.8 4.2e-05 24.2 0.0 7.7 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98106.1 - 2.5e-13 50.1 0.5 0.045 14.0 0.0 6.4 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 CCL98106.1 - 4e-05 23.4 0.0 7.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 CCL98106.1 - 0.0028 17.0 0.0 0.074 12.4 0.0 2.1 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 CCL98106.1 - 0.013 14.5 0.1 6.1 5.7 0.1 3.3 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 CCL98106.1 - 0.017 14.5 0.1 2.2 7.6 0.1 2.4 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 CCL98106.1 - 0.017 13.7 0.0 4.9 5.6 0.0 2.8 3 0 0 3 3 3 0 Cytochrome D1 heme domain WD40 PF00400.32 CCL98107.1 - 6.1e-13 49.0 21.4 0.0092 16.8 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat Sigma70_r3 PF04539.16 CCL98107.1 - 0.044 13.9 0.1 0.044 13.9 0.1 2.3 3 0 0 3 3 3 0 Sigma-70 region 3 Cytochrom_D1 PF02239.16 CCL98107.1 - 0.14 10.7 2.3 10 4.5 0.0 3.3 3 1 0 3 3 3 0 Cytochrome D1 heme domain RicinB_lectin_2 PF14200.6 CCL98108.1 - 0.00012 22.7 0.0 0.00052 20.7 0.0 2.0 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Arginase PF00491.21 CCL98109.1 - 5.3e-88 295.1 0.1 6.8e-88 294.8 0.1 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 CCL98109.1 - 0.052 13.8 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 UPF0489 domain SUR7 PF06687.12 CCL98110.1 - 7.5e-20 71.5 12.4 1.1e-19 71.0 12.4 1.2 1 0 0 1 1 1 1 SUR7/PalI family TMEM52 PF14979.6 CCL98110.1 - 0.81 9.6 8.3 5.5 6.9 0.0 3.2 3 0 0 3 3 3 0 Transmembrane 52 DUF996 PF06195.13 CCL98110.1 - 0.99 9.7 11.3 7 6.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF996) Amastin PF07344.11 CCL98110.1 - 2 8.2 12.0 3.9 7.3 12.0 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein Acetyltransf_3 PF13302.7 CCL98111.1 - 1.2e-13 52.0 0.0 2.1e-13 51.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCL98111.1 - 0.0005 20.3 0.1 0.0012 19.1 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CCL98111.1 - 0.16 11.7 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GTP_EFTU PF00009.27 CCL98112.1 - 9.4e-68 227.6 0.3 1.4e-67 227.0 0.3 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CCL98112.1 - 1.7e-33 115.0 0.0 7.5e-33 112.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 CCL98112.1 - 2e-22 79.0 0.0 4.3e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CCL98112.1 - 3.6e-13 49.4 0.0 9e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CCL98112.1 - 3.9e-12 46.4 0.0 1e-11 45.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCL98112.1 - 6.4e-05 23.0 0.3 0.00014 22.0 0.3 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase APH PF01636.23 CCL98113.1 - 2.6e-10 40.6 0.3 3.7e-10 40.2 0.3 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CCL98113.1 - 0.03 13.6 0.0 0.076 12.3 0.0 1.5 1 1 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 CCL98113.1 - 0.2 11.2 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF512 PF04459.12 CCL98115.1 - 0.013 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF512) Phage_CP76 PF06892.11 CCL98115.1 - 0.016 14.8 0.2 0.026 14.0 0.2 1.2 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) PI-PLC-X PF00388.19 CCL98115.1 - 0.028 14.0 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Utp11 PF03998.13 CCL98117.1 - 3e-72 243.5 18.1 4e-72 243.1 18.1 1.2 1 0 0 1 1 1 1 Utp11 protein PGA2 PF07543.12 CCL98117.1 - 0.016 15.2 1.3 0.016 15.2 1.3 2.8 3 1 0 3 3 3 0 Protein trafficking PGA2 Type2_restr_D3 PF16902.5 CCL98117.1 - 0.062 13.2 0.3 0.3 11.0 0.1 2.2 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain Glyco_trans_1_2 PF13524.6 CCL98117.1 - 4.8 7.6 8.6 4.4 7.8 1.8 2.8 3 0 0 3 3 3 0 Glycosyl transferases group 1 VHS PF00790.19 CCL98118.1 - 5.3e-23 81.4 0.1 1.9e-22 79.7 0.1 2.0 1 1 0 1 1 1 1 VHS domain GAT PF03127.14 CCL98118.1 - 3.7e-06 27.1 0.6 8.7e-06 26.0 0.6 1.7 1 0 0 1 1 1 1 GAT domain Auts2 PF15336.6 CCL98118.1 - 0.81 9.8 8.0 1.8 8.6 8.0 1.6 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein RPOL_N PF14700.6 CCL98118.1 - 4.9 6.5 12.7 0.38 10.1 7.3 1.8 1 1 1 2 2 2 0 DNA-directed RNA polymerase N-terminal tRNA-synt_2b PF00587.25 CCL98119.1 - 5.6e-23 81.8 0.0 8.2e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CCL98119.1 - 2.6e-05 24.4 0.5 4.8e-05 23.6 0.5 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Rep_fac_C PF08542.11 CCL98120.1 - 1.2e-27 96.1 0.0 2.5e-27 95.1 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CCL98120.1 - 2e-10 41.2 0.0 4.1e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CCL98120.1 - 2.4e-10 40.4 0.1 5.7e-10 39.2 0.1 1.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 CCL98120.1 - 5.3e-06 26.5 0.0 1.9e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCL98120.1 - 0.001 19.3 0.0 0.75 10.1 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_3 PF07726.11 CCL98120.1 - 0.0016 18.3 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 CCL98120.1 - 0.0023 17.7 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 CCL98120.1 - 0.0052 17.2 0.0 0.41 11.0 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_assoc_2 PF16193.5 CCL98120.1 - 0.013 15.9 0.0 0.033 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain DNA_pol3_delta PF06144.13 CCL98120.1 - 0.02 14.7 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_11 PF13086.6 CCL98120.1 - 0.16 11.7 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ParA PF10609.9 CCL98121.1 - 9.6e-89 297.1 0.0 1.1e-88 296.9 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCL98121.1 - 7e-08 32.6 0.0 2.8e-07 30.7 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CCL98121.1 - 3.6e-06 26.4 0.4 0.00092 18.5 0.2 2.1 2 0 0 2 2 2 2 Anion-transporting ATPase MipZ PF09140.11 CCL98121.1 - 4e-06 26.3 0.0 1.6e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.6 CCL98121.1 - 4.9e-06 26.6 0.0 0.0046 16.9 0.0 2.1 2 0 0 2 2 2 2 AAA domain CBP_BcsQ PF06564.12 CCL98121.1 - 0.021 14.3 0.0 0.054 13.0 0.0 1.6 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 CCL98121.1 - 0.04 13.5 0.3 0.092 12.3 0.2 1.8 2 1 0 2 2 2 0 AAA domain AAA_26 PF13500.6 CCL98121.1 - 0.051 13.4 0.1 7.2 6.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCL98121.1 - 0.12 12.6 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCL98121.1 - 0.16 12.3 0.7 0.31 11.4 0.4 1.7 2 1 0 2 2 2 0 AAA ATPase domain RRM_1 PF00076.22 CCL98124.1 - 2.4e-18 65.7 0.0 1.7e-11 43.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_pol_Rpb6 PF01192.22 CCL98125.1 - 8e-15 54.5 0.1 1.2e-14 54.0 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 SIR2 PF02146.17 CCL98126.1 - 1.1e-33 116.6 0.0 1.8e-22 80.1 0.0 2.2 2 0 0 2 2 2 2 Sir2 family EF_TS PF00889.19 CCL98127.1 - 3e-16 59.7 0.0 5.5e-15 55.5 0.0 2.3 2 0 0 2 2 2 2 Elongation factor TS Gar1 PF04410.14 CCL98128.1 - 3.4e-33 114.6 0.1 3.4e-33 114.6 0.1 1.9 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region PEHE PF15275.6 CCL98129.1 - 1e-05 26.2 0.3 1e-05 26.2 0.3 2.7 2 1 0 2 2 2 1 PEHE domain SAS4 PF15460.6 CCL98129.1 - 4.7e-05 23.4 4.5 0.00014 21.9 4.5 1.7 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Spem1 PF15670.5 CCL98130.1 - 0.024 14.2 5.9 0.036 13.6 5.9 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 Presenilin PF01080.17 CCL98130.1 - 0.09 11.5 1.2 0.097 11.4 1.2 1.1 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CCL98130.1 - 0.18 10.7 6.9 0.24 10.3 6.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Bromodomain PF00439.25 CCL98132.1 - 2e-35 120.7 2.6 4.7e-18 65.0 0.5 2.6 2 0 0 2 2 2 2 Bromodomain Usp PF00582.26 CCL98132.1 - 0.039 14.5 0.8 0.039 14.5 0.8 1.9 2 0 0 2 2 2 0 Universal stress protein family YL1 PF05764.13 CCL98132.1 - 0.065 13.3 12.6 0.18 11.9 12.6 1.7 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 CCL98132.1 - 0.26 9.6 6.9 0.5 8.6 6.9 1.4 1 0 0 1 1 1 0 CDC45-like protein DUF3408 PF11888.8 CCL98132.1 - 0.38 10.9 6.7 1.1 9.4 6.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Draxin PF15550.6 CCL98132.1 - 2.8 7.7 9.1 7 6.4 8.7 1.9 1 1 0 1 1 1 0 Draxin UPF0239 PF06783.11 CCL98132.1 - 5.7 7.2 6.0 16 5.8 6.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) BTB PF00651.31 CCL98133.1 - 0.047 13.9 0.0 0.074 13.3 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain Cyt-b5 PF00173.28 CCL98134.1 - 1.1e-05 25.4 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 CCL98134.1 - 0.028 14.3 24.7 0.078 12.8 20.1 2.7 1 1 0 1 1 1 0 Fatty acid desaturase CutC PF03932.14 CCL98135.1 - 1.6e-50 171.4 0.1 1.1e-48 165.4 0.1 2.1 1 1 0 1 1 1 1 CutC family PLD_C PF12357.8 CCL98135.1 - 0.07 13.0 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Phospholipase D C terminal RabGAP-TBC PF00566.18 CCL98138.1 - 3e-49 167.6 0.0 4e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HA2 PF04408.23 CCL98140.1 - 3.5e-20 72.3 1.2 5.3e-20 71.7 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCL98140.1 - 6.5e-15 55.3 0.0 1.4e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCL98140.1 - 7.1e-14 52.1 0.2 2.4e-13 50.4 0.2 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCL98140.1 - 3.3e-09 36.7 0.3 1.2e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCL98140.1 - 0.0062 16.8 0.5 0.038 14.3 0.5 2.3 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCL98140.1 - 0.05 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 CCL98140.1 - 0.12 12.7 0.6 1 9.8 0.6 2.6 1 1 0 1 1 1 0 AAA ATPase domain HA2 PF04408.23 CCL98141.1 - 7.4e-25 87.3 0.0 7.4e-25 87.3 0.0 2.3 3 0 0 3 3 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCL98141.1 - 1.9e-23 82.6 0.0 3.7e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCL98141.1 - 8.1e-14 51.9 0.0 3e-13 50.1 0.0 2.0 2 0 0 2 2 1 1 Helicase conserved C-terminal domain S1 PF00575.23 CCL98141.1 - 1.5e-07 31.7 0.3 3.2e-07 30.6 0.3 1.5 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 CCL98141.1 - 6.8e-05 22.7 0.0 0.00014 21.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCL98141.1 - 0.00011 22.5 0.0 0.00031 21.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCL98141.1 - 0.00016 21.5 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCL98141.1 - 0.00043 19.4 0.0 0.0012 17.9 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 CCL98141.1 - 0.0049 16.1 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 CCL98141.1 - 0.0084 16.5 0.1 0.018 15.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CCL98141.1 - 0.049 14.1 0.5 1.3 9.5 0.1 3.2 2 1 1 3 3 3 0 ABC transporter PhoH PF02562.16 CCL98141.1 - 0.076 12.5 0.9 0.73 9.2 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 CCL98141.1 - 0.17 11.4 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NTF2 PF02136.20 CCL98142.1 - 1.5e-11 44.9 0.0 4.2e-10 40.2 0.0 2.1 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 CCL98142.1 - 0.00035 20.6 0.0 0.0004 20.4 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 2OG-FeII_Oxy PF03171.20 CCL98143.1 - 2.3e-16 60.1 0.0 6.3e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCL98143.1 - 4.2e-12 46.9 0.0 9e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Adaptin_N PF01602.20 CCL98144.1 - 1.1e-106 357.5 0.0 1.6e-106 357.0 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCL98144.1 - 1.1e-14 54.8 0.7 2.3e-09 37.5 0.0 3.2 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCL98144.1 - 1.1e-07 32.1 4.2 0.005 17.2 0.5 4.9 4 3 2 6 6 6 3 HEAT repeats HEAT PF02985.22 CCL98144.1 - 2.6e-06 27.2 6.3 17 6.0 0.0 6.6 6 1 1 7 7 7 2 HEAT repeat RTP1_C1 PF10363.9 CCL98144.1 - 8.1e-06 26.0 1.7 0.22 11.7 0.4 3.5 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.9 CCL98144.1 - 1.7e-05 23.5 1.7 0.0096 14.5 0.5 2.5 2 0 0 2 2 2 2 Proteasome non-ATPase 26S subunit RasGEF_N_2 PF14663.6 CCL98144.1 - 0.0057 17.0 0.8 2.6 8.5 0.0 3.4 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_EZ PF13513.6 CCL98144.1 - 0.051 14.1 5.0 23 5.6 0.0 5.8 6 0 0 6 6 6 0 HEAT-like repeat Pkinase PF00069.25 CCL98145.1 - 2.3e-71 240.2 0.0 3.2e-71 239.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98145.1 - 1.7e-51 175.0 0.0 2.5e-51 174.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCL98145.1 - 3.7e-05 22.7 0.0 6.3e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCL98145.1 - 8.2e-05 22.1 0.0 0.0025 17.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCL98145.1 - 0.0012 17.9 0.0 0.17 10.8 0.0 2.1 2 0 0 2 2 2 2 Haspin like kinase domain DUF1241 PF06840.11 CCL98145.1 - 0.0019 17.9 0.1 0.0036 17.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) DUF5133 PF17196.4 CCL98145.1 - 0.13 12.4 0.1 0.31 11.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF5133) UQ_con PF00179.26 CCL98146.1 - 1.2e-10 41.2 0.0 1.3e-09 37.8 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme ALIX_LYPXL_bnd PF13949.6 CCL98146.1 - 4.5 6.5 9.9 8.1 5.6 0.0 2.7 3 1 0 3 3 3 0 ALIX V-shaped domain binding to HIV Cation_efflux PF01545.21 CCL98147.1 - 9.9e-19 67.8 10.3 1.3e-18 67.5 10.3 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCL98147.1 - 2.1e-11 43.8 0.6 4.4e-11 42.8 0.2 1.7 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter ADH_zinc_N PF00107.26 CCL98150.1 - 1.7e-23 83.0 0.0 3e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCL98150.1 - 7.8e-18 65.8 0.0 1.7e-17 64.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCL98150.1 - 5.3e-07 29.5 0.0 1.5e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain PA PF02225.22 CCL98150.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 PA domain ING PF12998.7 CCL98153.1 - 3e-11 43.8 0.1 4.4e-11 43.3 0.1 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CCL98153.1 - 8.6e-06 25.6 5.4 1.4e-05 24.9 5.4 1.4 1 0 0 1 1 1 1 PHD-finger zf-RRN7 PF11781.8 CCL98153.1 - 3.5 7.4 10.2 14 5.5 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 cEGF PF12662.7 CCL98154.1 - 0.02 14.8 0.3 0.07 13.1 0.3 2.0 1 0 0 1 1 1 0 Complement Clr-like EGF-like Exo5 PF09810.9 CCL98155.1 - 1.4e-68 232.1 0.0 2.7e-57 195.0 0.0 2.2 2 0 0 2 2 2 2 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 CCL98155.1 - 0.0071 16.3 0.0 2.3 8.1 0.0 3.1 3 0 0 3 3 3 1 PD-(D/E)XK nuclease superfamily Pkinase PF00069.25 CCL98156.1 - 6.5e-39 133.9 0.0 9.5e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98156.1 - 3e-28 98.8 0.0 4.4e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCL98156.1 - 0.00025 20.1 0.4 0.00049 19.1 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain NAD_binding_2 PF03446.15 CCL98158.1 - 6.2e-24 85.0 0.0 1.2e-23 84.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCL98158.1 - 2.4e-09 37.5 0.1 6.5e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 CCL98158.1 - 4.7e-08 33.2 0.1 9.9e-08 32.1 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCL98158.1 - 6.5e-07 29.8 0.1 1.2e-06 28.9 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 CCL98158.1 - 0.035 13.0 0.0 0.06 12.3 0.0 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family NAD_binding_3 PF03447.16 CCL98158.1 - 0.095 13.4 0.1 0.18 12.5 0.1 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain dsrm PF00035.26 CCL98160.1 - 3.7e-11 43.5 0.0 4.2e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Double-stranded RNA binding motif Sec3-PIP2_bind PF15277.6 CCL98161.1 - 1.7e-21 76.2 0.0 2.3e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sigma_reg_C PF13791.6 CCL98161.1 - 0.2 11.9 0.0 0.29 11.3 0.0 1.2 1 0 0 1 1 1 0 Sigma factor regulator C-terminal Fip1 PF05182.13 CCL98162.1 - 2.9e-20 71.5 0.4 4.6e-20 70.8 0.4 1.3 1 0 0 1 1 1 1 Fip1 motif HEAT_EZ PF13513.6 CCL98163.1 - 0.0007 20.0 0.3 9.2 6.9 0.0 4.9 5 0 0 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 CCL98163.1 - 0.0015 18.6 0.1 0.014 15.4 0.1 2.3 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 CCL98163.1 - 0.005 16.8 0.0 0.005 16.8 0.0 3.9 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CCL98163.1 - 0.022 15.1 0.1 0.36 11.2 0.0 2.8 2 0 0 2 2 2 0 HEAT repeats HEAT PF02985.22 CCL98163.1 - 0.029 14.6 4.7 16 6.1 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat Adaptin_N PF01602.20 CCL98163.1 - 0.036 12.6 0.8 0.088 11.3 0.2 1.7 2 0 0 2 2 2 0 Adaptin N terminal region Imm47 PF15573.6 CCL98163.1 - 0.1 12.1 0.2 0.65 9.4 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 47 Fasciclin PF02469.22 CCL98164.1 - 1.4e-06 28.5 0.0 1.3e-05 25.4 0.0 2.0 1 1 0 1 1 1 1 Fasciclin domain Vps39_1 PF10366.9 CCL98167.1 - 6.8e-26 90.7 0.0 2.1e-25 89.1 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 CCL98167.1 - 8.3e-22 77.7 0.2 2.6e-21 76.1 0.2 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Ank_2 PF12796.7 CCL98167.1 - 9.9e-21 74.1 0.0 3e-08 34.2 0.0 4.6 2 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCL98167.1 - 1.4e-19 70.2 7.4 0.00026 21.5 0.1 6.9 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCL98167.1 - 3.2e-15 56.0 9.6 0.00019 21.6 0.0 6.0 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 CCL98167.1 - 8.5e-13 48.1 5.2 0.0039 17.6 0.0 6.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 CCL98167.1 - 7.2e-12 44.4 8.9 0.00075 19.8 0.0 7.3 8 0 0 8 8 6 3 Ankyrin repeat CNH PF00780.22 CCL98167.1 - 3.5e-09 36.7 0.0 9.6e-09 35.2 0.0 1.6 1 1 0 1 1 1 1 CNH domain Clathrin PF00637.20 CCL98167.1 - 0.0022 17.9 0.0 0.49 10.3 0.0 3.2 3 0 0 3 3 3 1 Region in Clathrin and VPS TPR_1 PF00515.28 CCL98167.1 - 0.12 12.3 1.0 14 5.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCL98167.1 - 0.13 13.0 8.1 63 4.6 0.9 5.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCL98167.1 - 0.2 12.2 0.1 0.2 12.2 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCL98167.1 - 1.4 9.3 5.6 46 4.5 0.0 4.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TAP_C PF03943.13 CCL98168.1 - 4e-15 55.2 0.2 1.7e-14 53.1 0.0 2.1 2 0 0 2 2 2 1 TAP C-terminal domain NTF2 PF02136.20 CCL98168.1 - 6.4e-06 26.7 0.0 9.2e-05 23.0 0.0 2.4 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain UBA_4 PF14555.6 CCL98168.1 - 0.0087 15.9 0.1 0.024 14.5 0.1 1.8 1 0 0 1 1 1 1 UBA-like domain LRR_4 PF12799.7 CCL98168.1 - 0.018 15.5 2.4 2.4 8.7 0.6 3.0 1 1 3 4 4 4 0 Leucine Rich repeats (2 copies) PIG-H PF10181.9 CCL98168.1 - 0.12 12.2 0.1 0.39 10.6 0.1 1.9 1 1 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component SnoaL_4 PF13577.6 CCL98168.1 - 0.15 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain Myb_DNA-binding PF00249.31 CCL98169.1 - 0.0042 17.2 1.2 0.0077 16.4 1.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain DEDD_Tnp_IS110 PF01548.17 CCL98170.1 - 0.054 13.4 0.2 0.092 12.6 0.2 1.3 1 0 0 1 1 1 0 Transposase LysM PF01476.20 CCL98172.1 - 0.0046 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 LysM domain Ribosomal_S28e PF01200.18 CCL98172.1 - 0.063 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S28e GFA PF04828.14 CCL98173.1 - 5.1e-10 39.6 0.7 1.1e-09 38.5 0.7 1.5 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Exo_endo_phos PF03372.23 CCL98173.1 - 4.9e-07 29.5 0.1 1.3e-06 28.1 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.16 CCL98174.1 - 1.1e-20 73.8 57.2 7.9e-17 61.2 40.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3432 PF11914.8 CCL98174.1 - 2.6 8.4 6.9 31 4.9 0.6 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3432) APG17 PF04108.12 CCL98175.1 - 1.6e-72 244.9 15.8 4.4e-65 220.3 8.9 2.0 2 0 0 2 2 2 2 Autophagy protein Apg17 DUF745 PF05335.13 CCL98175.1 - 0.068 12.9 8.5 0.016 14.9 4.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Nsp1_C PF05064.13 CCL98175.1 - 2 8.3 7.6 40 4.0 2.1 3.5 3 1 0 3 3 3 0 Nsp1-like C-terminal region MBOAT_2 PF13813.6 CCL98176.1 - 6.1e-19 68.1 4.1 1.8e-18 66.6 4.1 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Actin PF00022.19 CCL98177.1 - 7e-86 288.4 0.0 1.4e-84 284.1 0.0 2.0 1 1 0 1 1 1 1 Actin UPF0061 PF02696.14 CCL98178.1 - 7.3e-89 298.7 0.0 4.2e-62 210.5 0.0 3.7 3 1 0 3 3 3 3 Uncharacterized ACR, YdiU/UPF0061 family Acyl-CoA_dh_1 PF00441.24 CCL98179.1 - 8.1e-30 104.0 0.9 1.2e-29 103.5 0.9 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCL98179.1 - 2.8e-18 65.9 0.1 1.1e-17 64.0 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 CCL98179.1 - 2.8e-15 56.2 0.0 6.9e-15 55.0 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 CCL98179.1 - 1.6e-13 51.3 0.0 3.4e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCL98179.1 - 3.2e-07 30.7 0.2 6.1e-07 29.8 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Pro_CA PF00484.19 CCL98180.1 - 2.6e-41 141.5 0.5 3.5e-41 141.1 0.5 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Abhydrolase_1 PF00561.20 CCL98180.1 - 0.017 14.7 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Mesd PF10185.9 CCL98180.1 - 0.19 11.6 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor Asp PF00026.23 CCL98181.1 - 4.9e-29 101.8 4.8 2.6e-27 96.1 4.8 2.2 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CCL98181.1 - 1.1e-06 29.2 2.5 1.1e-05 26.0 1.3 2.6 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CCL98181.1 - 0.00021 21.8 2.2 0.00035 21.1 0.3 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease TMEM154 PF15102.6 CCL98181.1 - 0.032 14.1 0.1 0.032 14.1 0.1 1.8 2 0 0 2 2 2 0 TMEM154 protein family Carn_acyltransf PF00755.20 CCL98183.1 - 5.9e-209 695.5 0.0 6.7e-209 695.3 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase IBR PF01485.21 CCL98184.1 - 1.2e-09 38.3 16.9 2.5e-09 37.2 16.9 1.6 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain tRNA-synt_2 PF00152.20 CCL98185.1 - 1.2e-77 261.1 0.0 1.5e-77 260.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCL98185.1 - 3.8e-10 39.6 0.0 1.1e-09 38.1 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCL98185.1 - 1.8e-08 34.1 0.0 0.00011 21.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) IHABP4_N PF16174.5 CCL98185.1 - 0.13 12.8 7.6 0.43 11.2 2.5 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Glyco_tranf_2_3 PF13641.6 CCL98186.1 - 1.1e-30 107.2 0.0 1.5e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCL98186.1 - 2.6e-10 40.4 0.0 3.8e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCL98186.1 - 6.1e-08 32.3 0.0 3.5e-07 29.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 CCL98186.1 - 0.022 14.7 6.2 0.046 13.6 6.2 1.6 1 1 0 1 1 1 0 Glycosyl transferase family group 2 HSP70 PF00012.20 CCL98188.1 - 1e-159 532.6 0.5 1e-159 532.6 0.5 1.5 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CCL98188.1 - 1.5e-09 37.1 0.9 1.3e-08 34.1 0.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein ACCA PF03255.14 CCL98188.1 - 0.14 12.0 1.0 0.46 10.3 1.0 1.8 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GATase_5 PF13507.6 CCL98189.1 - 3.2e-102 341.1 0.0 4.6e-102 340.6 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 CCL98189.1 - 2.7e-39 134.8 1.2 2.5e-28 99.2 0.1 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 CCL98189.1 - 3.1e-32 110.9 0.0 6.8e-32 109.9 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 CCL98189.1 - 2.1e-22 79.4 0.0 4.4e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 CCL98189.1 - 0.033 14.8 0.2 1 10.1 0.0 3.2 3 0 0 3 3 3 0 AIR synthase related protein, N-terminal domain Use1 PF09753.9 CCL98191.1 - 2.4e-15 57.0 0.0 3.5e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Membrane fusion protein Use1 R3H PF01424.22 CCL98192.1 - 3.1e-13 49.5 0.0 1.3e-12 47.5 0.0 2.1 2 0 0 2 2 2 1 R3H domain G-patch_2 PF12656.7 CCL98192.1 - 0.00025 21.0 0.6 0.00025 21.0 0.6 2.4 2 0 0 2 2 2 1 G-patch domain Ig_mannosidase PF17753.1 CCL98193.1 - 9.6e-12 44.5 0.0 3.8e-11 42.6 0.0 2.0 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 CCL98193.1 - 7.8e-11 42.4 0.1 2.3e-10 40.9 0.1 1.9 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CCL98193.1 - 0.035 14.8 0.0 0.095 13.4 0.0 1.8 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 AA_permease PF00324.21 CCL98194.1 - 1.9e-121 406.0 35.7 1.7e-88 297.4 15.7 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 CCL98194.1 - 2.1e-37 129.0 39.0 8.4e-28 97.3 16.5 2.0 1 1 1 2 2 2 2 Amino acid permease Glyco_hydro_28 PF00295.17 CCL98195.1 - 2e-20 73.1 0.2 2.7e-20 72.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 PQQ_2 PF13360.6 CCL98195.1 - 0.026 14.1 0.1 0.046 13.3 0.1 1.4 1 0 0 1 1 1 0 PQQ-like domain Tlr3_TMD PF17968.1 CCL98197.1 - 2.3 8.5 6.7 24 5.2 0.8 3.3 2 0 0 2 2 2 0 Toll-like receptor 3 trans-membrane domain Methyltransf_22 PF13383.6 CCL98198.1 - 1.1e-20 74.3 0.0 2.9e-19 69.6 0.0 2.1 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_21 PF05050.12 CCL98198.1 - 1.2e-07 31.9 0.0 1.9e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain Pkinase PF00069.25 CCL98200.1 - 3.7e-67 226.5 0.0 4.9e-67 226.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98200.1 - 3.1e-38 131.5 0.0 4.4e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 CCL98200.1 - 1.1e-15 57.7 0.2 2e-15 56.9 0.2 1.4 1 0 0 1 1 1 1 FHA domain Kdo PF06293.14 CCL98200.1 - 2.7e-05 23.6 0.5 5.1e-05 22.7 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCL98200.1 - 0.0021 17.4 0.0 0.0064 15.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCL98200.1 - 0.033 14.1 0.9 0.61 10.0 0.0 3.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Yop-YscD_cpl PF16697.5 CCL98200.1 - 0.043 14.1 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain But2 PF09792.9 CCL98203.1 - 2.7e-11 44.1 0.0 4.3e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain DUF5028 PF16431.5 CCL98204.1 - 0.13 12.2 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5028) Vps16_C PF04840.12 CCL98206.1 - 8.9e-84 281.3 0.2 1.2e-83 280.8 0.2 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 CCL98206.1 - 1.4e-80 271.1 0.0 2.2e-80 270.4 0.0 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region RIB43A PF05914.12 CCL98206.1 - 0.012 14.4 0.5 0.018 13.8 0.5 1.1 1 0 0 1 1 1 0 RIB43A CHCH PF06747.13 CCL98208.1 - 0.015 15.4 3.5 0.028 14.6 3.5 1.5 1 0 0 1 1 1 0 CHCH domain DUF2076 PF09849.9 CCL98208.1 - 0.43 10.6 19.3 1 9.3 19.3 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) MBA1 PF07961.11 CCL98209.1 - 1.4e-06 27.6 0.0 2.3e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 MBA1-like protein TPR_2 PF07719.17 CCL98209.1 - 1.6e-06 27.8 4.6 0.052 13.7 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCL98209.1 - 1.8e-06 27.5 0.1 0.077 13.1 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCL98209.1 - 6.5e-06 26.5 4.4 1.8 9.6 0.1 5.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCL98209.1 - 1.2e-05 25.5 6.3 0.022 15.0 0.1 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat Tim44 PF04280.15 CCL98209.1 - 2.3e-05 24.5 0.0 5.8e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Tim44-like domain TPR_8 PF13181.6 CCL98209.1 - 3.9e-05 23.5 1.1 0.78 10.1 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCL98209.1 - 0.00015 21.4 2.4 0.49 10.3 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat MIT PF04212.18 CCL98209.1 - 0.021 14.9 0.0 5.2 7.2 0.0 3.0 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Sec62 PF03839.16 CCL98210.1 - 4.7e-50 170.1 3.8 8.6e-50 169.2 3.8 1.5 1 1 0 1 1 1 1 Translocation protein Sec62 Mitoc_mL59 PF18126.1 CCL98211.1 - 5.6e-42 143.1 5.9 1e-41 142.2 5.9 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Formyl_trans_N PF00551.19 CCL98212.1 - 9.5e-22 77.6 0.0 1.9e-21 76.7 0.0 1.4 2 0 0 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.18 CCL98212.1 - 3.2e-13 49.7 0.0 4.8e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain DEAD PF00270.29 CCL98213.1 - 6.9e-43 146.4 0.2 1.1e-42 145.8 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCL98213.1 - 5.9e-28 97.4 1.0 1.1e-26 93.3 0.3 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCL98213.1 - 7.1e-06 26.1 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CCL98213.1 - 0.016 14.6 0.2 0.031 13.6 0.2 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Gly_transf_sug PF04488.15 CCL98214.1 - 2.1e-06 28.2 0.0 3.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 CCL98214.1 - 0.028 13.8 0.4 0.045 13.1 0.4 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Sdh5 PF03937.16 CCL98215.1 - 5.7e-27 93.5 1.7 9.3e-27 92.8 1.7 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Lentiviral_Tat PF02998.14 CCL98215.1 - 0.68 10.0 3.1 0.61 10.1 1.7 1.6 2 0 0 2 2 2 0 Lentiviral Tat protein Metallophos PF00149.28 CCL98216.1 - 2e-40 139.5 0.1 2.6e-40 139.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCL98216.1 - 1e-21 77.1 0.5 2.1e-21 76.1 0.2 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain PH_9 PF15410.6 CCL98217.1 - 6.4e-09 36.2 0.0 6e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain PH PF00169.29 CCL98217.1 - 0.0003 21.3 0.0 0.011 16.2 0.0 2.5 2 0 0 2 2 2 1 PH domain Abhydrolase_3 PF07859.13 CCL98218.1 - 3.8e-27 95.5 0.0 2.3e-22 79.9 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCL98218.1 - 3.5e-05 22.9 0.0 0.00015 20.7 0.0 1.8 2 0 0 2 2 2 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 CCL98218.1 - 0.022 14.1 0.0 0.25 10.6 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCL98218.1 - 1.6 9.3 10.9 0.41 11.2 6.9 2.1 2 1 0 2 2 2 0 Alpha/beta hydrolase family DUF1289 PF06945.13 CCL98219.1 - 0.029 14.2 0.5 0.065 13.0 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) DUF1769 PF08588.10 CCL98221.1 - 4.8e-22 77.9 0.0 1.2e-21 76.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) DFP PF04127.15 CCL98223.1 - 2.1e-21 76.6 0.0 1.5e-12 47.8 0.0 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein HAD PF12710.7 CCL98223.1 - 0.018 15.4 0.0 0.62 10.4 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Abhydrolase_1 PF00561.20 CCL98224.1 - 1.5e-24 87.0 0.0 3e-19 69.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL98224.1 - 1.5e-16 61.7 9.3 1.2e-15 58.7 9.3 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL98224.1 - 1.9e-09 37.1 0.0 3.4e-08 33.0 0.0 2.3 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 CCL98224.1 - 0.0081 15.1 0.0 0.017 14.1 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme DLH PF01738.18 CCL98224.1 - 0.014 15.0 0.0 4.3 6.8 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Chlorophyllase PF07224.11 CCL98224.1 - 0.059 12.4 0.9 0.087 11.8 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase Dioxygenase_C PF00775.21 CCL98225.1 - 4e-46 156.7 0.0 5.3e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CCL98225.1 - 7.7e-29 99.4 0.0 1.6e-28 98.3 0.0 1.6 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 CCL98225.1 - 0.0051 17.1 0.2 0.03 14.6 0.3 2.2 2 1 0 2 2 2 1 Carboxypeptidase regulatory-like domain ACOX PF01756.19 CCL98225.1 - 0.097 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA oxidase XPG_I PF00867.18 CCL98226.1 - 1e-22 80.2 0.0 2.3e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CCL98226.1 - 2.2e-07 31.3 0.0 4.6e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 CCL98226.1 - 1.6e-06 28.6 0.0 3.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 CCL98226.1 - 7.1e-05 22.4 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing TPR_2 PF07719.17 CCL98226.1 - 0.0065 16.5 0.1 0.021 14.9 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCL98226.1 - 0.016 15.0 0.1 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat HHH_5 PF14520.6 CCL98226.1 - 0.025 15.2 0.0 0.069 13.8 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain TPR_8 PF13181.6 CCL98226.1 - 0.063 13.5 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCL98226.1 - 0.12 12.3 0.2 0.29 11.1 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCL98226.1 - 0.18 12.7 0.4 0.65 11.0 0.4 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_4 PF07721.14 CCL98226.1 - 2.7 8.9 5.0 6.8 7.6 2.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 CCL98227.1 - 4.2e-10 39.5 7.4 0.00022 21.5 0.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCL98227.1 - 1.2e-06 28.9 6.4 0.0048 17.6 1.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCL98227.1 - 8.7e-06 25.9 8.5 0.00029 21.1 0.2 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCL98227.1 - 0.0029 17.6 0.4 0.0029 17.6 0.4 2.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 CCL98227.1 - 0.024 15.1 2.3 0.059 13.8 0.4 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PIG-P PF08510.12 CCL98228.1 - 1.1e-35 122.2 3.3 1.2e-35 122.0 3.3 1.0 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 CCL98228.1 - 0.00058 20.1 7.5 0.0013 18.9 7.5 1.6 1 1 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) 5-FTHF_cyc-lig PF01812.20 CCL98229.1 - 2.2e-39 135.3 0.0 2.5e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family MinC_N PF05209.13 CCL98229.1 - 0.097 12.6 0.1 0.29 11.1 0.0 1.7 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain Rad51 PF08423.11 CCL98230.1 - 1.2e-07 31.3 0.0 1.5e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Rad51 DnaB_C PF03796.15 CCL98230.1 - 7.7e-06 25.4 0.0 1.5e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 CCL98230.1 - 0.0023 17.7 0.1 0.014 15.2 0.0 2.1 2 1 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 CCL98230.1 - 0.0042 16.7 0.0 0.024 14.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 CCL98230.1 - 0.0047 16.3 0.6 0.04 13.3 0.6 2.1 1 1 0 1 1 1 1 KaiC ABC_tran PF00005.27 CCL98230.1 - 0.011 16.3 0.0 0.013 16.0 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 CCL98230.1 - 0.021 14.8 0.0 0.043 13.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CbiA PF01656.23 CCL98230.1 - 0.044 13.8 0.1 0.08 13.0 0.1 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 CCL98230.1 - 0.061 13.7 0.0 0.087 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain TIP49 PF06068.13 CCL98230.1 - 0.084 12.1 0.1 0.18 11.0 0.1 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain AAA_7 PF12775.7 CCL98230.1 - 0.092 12.3 0.5 0.33 10.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region RRM_1 PF00076.22 CCL98231.1 - 1.8e-26 91.7 0.0 2e-11 43.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCL98231.1 - 0.15 12.2 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif HNH_2 PF13391.6 CCL98232.1 - 2.8e-13 49.8 0.1 1e-12 48.0 0.1 2.0 2 0 0 2 2 2 1 HNH endonuclease HEAT PF02985.22 CCL98233.1 - 0.005 17.0 0.0 0.16 12.3 0.0 3.1 2 0 0 2 2 2 1 HEAT repeat HEAT_2 PF13646.6 CCL98233.1 - 0.17 12.3 0.3 4.9 7.6 0.0 2.8 2 0 0 2 2 2 0 HEAT repeats Cnd1 PF12717.7 CCL98233.1 - 0.37 10.8 1.7 33 4.5 0.0 3.2 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Glyco_hydro_16 PF00722.21 CCL98234.1 - 3.2e-41 140.7 5.1 4.4e-41 140.3 5.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 CCL98234.1 - 0.00049 20.5 14.5 0.0013 19.2 14.5 1.6 1 0 0 1 1 1 1 Chitin recognition protein MutS_V PF00488.21 CCL98235.1 - 3.9e-66 222.7 0.2 7.5e-66 221.8 0.2 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCL98235.1 - 1.3e-36 126.7 0.3 3.6e-36 125.2 0.3 1.8 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 CCL98235.1 - 2.7e-20 72.7 0.8 1e-19 70.8 0.8 2.1 1 1 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CCL98235.1 - 1.5e-09 38.3 0.0 4.2e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CCL98235.1 - 0.0087 16.4 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV NMO PF03060.15 CCL98236.1 - 8.1e-24 84.6 0.0 9.1e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCL98236.1 - 3.2e-06 26.4 0.2 3.5e-06 26.3 0.2 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCL98236.1 - 0.0012 17.9 0.4 0.0018 17.4 0.4 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CCL98236.1 - 0.036 13.5 0.1 0.058 12.9 0.1 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein Glu_synthase PF01645.17 CCL98236.1 - 0.054 12.6 0.1 0.072 12.2 0.1 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase DHO_dh PF01180.21 CCL98236.1 - 0.17 11.1 0.2 0.24 10.6 0.2 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase DnaJ PF00226.31 CCL98237.1 - 2.9e-20 72.2 0.0 7.1e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Imm59 PF15597.6 CCL98237.1 - 0.059 13.9 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 59 DUF2058 PF09831.9 CCL98237.1 - 1.3 9.1 8.3 2.7 8.1 8.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Mcp5_PH PF12814.7 CCL98238.1 - 3.2e-44 150.0 0.1 6.5e-44 149.0 0.1 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 CCL98238.1 - 0.00013 22.4 0.0 0.00028 21.4 0.0 1.6 1 0 0 1 1 1 1 PH domain Lyase_8_N PF08124.11 CCL98238.1 - 3.2 6.6 6.7 1 8.2 2.8 2.0 2 0 0 2 2 2 0 Polysaccharide lyase family 8, N terminal alpha-helical domain FAD-SLDH PF12318.8 CCL98238.1 - 6 6.9 10.0 0.21 11.7 1.2 2.6 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF5340 PF17275.2 CCL98238.1 - 8.2 6.6 6.4 2.5 8.3 0.8 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5340) DSPc PF00782.20 CCL98239.1 - 5.9e-10 39.1 0.0 6.9e-10 38.9 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PHD PF00628.29 CCL98240.1 - 4e-06 26.6 7.4 6e-06 26.1 7.4 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 CCL98240.1 - 0.00076 19.7 0.6 0.001 19.2 0.6 1.3 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-C4_Topoisom PF01396.19 CCL98240.1 - 0.016 15.0 2.5 0.27 11.0 0.2 2.3 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-HC5HC2H_2 PF13832.6 CCL98240.1 - 0.057 13.6 0.6 0.076 13.2 0.6 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain ING PF12998.7 CCL98241.1 - 9e-09 35.8 0.1 0.00023 21.7 0.1 2.3 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding TolA_bind_tri PF16331.5 CCL98241.1 - 0.19 11.8 1.8 0.19 11.8 0.1 1.8 2 0 0 2 2 2 0 TolA binding protein trimerisation TRP PF06011.12 CCL98242.1 - 2e-28 99.3 21.2 5.7e-28 97.8 21.2 1.7 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CCL98242.1 - 1.1e-05 25.8 0.2 0.00016 22.0 0.2 2.2 2 0 0 2 2 2 1 ML-like domain E1_DerP2_DerF2 PF02221.15 CCL98242.1 - 0.00032 21.1 0.0 0.00049 20.5 0.0 1.3 1 0 0 1 1 1 1 ML domain CNH PF00780.22 CCL98243.1 - 7.7e-06 25.7 0.0 0.0078 15.9 0.0 2.4 2 0 0 2 2 2 2 CNH domain ADH_zinc_N PF00107.26 CCL98245.1 - 3.4e-12 46.5 0.0 5.2e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCL98245.1 - 1.5e-07 32.5 0.0 2.4e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCL98245.1 - 0.00012 22.0 0.2 0.00069 19.5 0.2 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Plant_vir_prot PF01307.17 CCL98245.1 - 0.015 15.6 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 Plant viral movement protein Nop14 PF04147.12 CCL98246.1 - 2.2e-293 975.8 27.6 4.1e-293 974.9 27.6 1.4 1 1 0 1 1 1 1 Nop14-like family Menin PF05053.13 CCL98246.1 - 0.21 9.9 7.1 0.45 8.8 7.1 1.5 1 0 0 1 1 1 0 Menin PI3_PI4_kinase PF00454.27 CCL98247.1 - 6.4e-53 180.1 0.0 1.2e-52 179.3 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 CCL98247.1 - 3.5e-25 87.9 0.0 1.5e-24 85.8 0.0 2.3 1 0 0 1 1 1 1 UME (NUC010) domain FAT PF02259.23 CCL98247.1 - 3.5e-23 82.4 0.0 8.7e-23 81.1 0.0 1.7 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 CCL98247.1 - 3.1e-11 42.9 0.1 8.2e-11 41.5 0.1 1.8 1 0 0 1 1 1 1 FATC domain DUF3385 PF11865.8 CCL98247.1 - 0.011 15.6 0.1 0.061 13.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) T2SSF PF00482.23 CCL98247.1 - 0.21 11.5 3.4 21 5.1 0.1 4.5 6 0 0 6 6 6 0 Type II secretion system (T2SS), protein F YEATS PF03366.16 CCL98248.1 - 6.3e-38 128.6 0.1 1e-37 127.9 0.1 1.4 1 0 0 1 1 1 1 YEATS family M16C_assoc PF08367.11 CCL98248.1 - 0.094 11.8 3.7 0.14 11.3 3.7 1.2 1 0 0 1 1 1 0 Peptidase M16C associated COX7a PF02238.15 CCL98249.1 - 1.2e-18 67.3 0.5 1.3e-18 67.1 0.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII LANC_like PF05147.13 CCL98249.1 - 0.036 12.6 0.0 0.038 12.6 0.0 1.0 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein Coiled-coil_56 PF09813.9 CCL98250.1 - 3.7e-05 23.7 0.0 6.3e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 56 Ribonucleas_3_3 PF14622.6 CCL98251.1 - 8.5e-15 55.0 0.0 1.3e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CCL98251.1 - 1.5e-10 41.6 0.0 4.7e-10 40.0 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 CCL98251.1 - 5.4e-08 33.4 0.0 9.1e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif PAPS_reduct PF01507.19 CCL98252.1 - 1.3e-40 139.2 0.0 1.8e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Aldedh PF00171.22 CCL98253.1 - 8.3e-152 505.9 0.7 1.1e-151 505.5 0.7 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ldh_2 PF02615.14 CCL98253.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase Phage_ABA_S PF18066.1 CCL98253.1 - 0.14 12.8 0.0 0.39 11.4 0.0 1.7 1 0 0 1 1 1 0 Phage ABA sandwich domain Phage_RpbA PF10789.9 CCL98253.1 - 0.18 11.8 0.0 0.6 10.2 0.0 1.8 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA UPF0029 PF01205.19 CCL98254.1 - 2.5e-32 111.3 0.0 3.7e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 CCL98254.1 - 6.5e-09 36.1 0.0 1.3e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 RWD domain Atg29_N PF18388.1 CCL98255.1 - 2.6e-17 62.4 0.2 5e-17 61.5 0.2 1.5 1 0 0 1 1 1 1 Atg29 N-terminal domain Nucleo_P87 PF07267.11 CCL98255.1 - 0.12 11.2 0.9 0.19 10.6 0.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ubiquitin PF00240.23 CCL98256.1 - 8.2e-07 28.7 0.0 1.3e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CCL98256.1 - 2e-05 24.4 2.7 9.6e-05 22.2 0.4 2.6 2 0 0 2 2 2 1 UBA/TS-N domain Asp_protease PF09668.10 CCL98256.1 - 5.9e-05 22.9 0.9 0.0012 18.7 0.1 2.3 1 1 1 2 2 2 1 Aspartyl protease UBA_4 PF14555.6 CCL98256.1 - 0.00011 21.9 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain XPC-binding PF09280.11 CCL98256.1 - 0.042 13.6 0.1 0.097 12.4 0.1 1.6 1 0 0 1 1 1 0 XPC-binding domain Rad60-SLD PF11976.8 CCL98256.1 - 0.11 12.3 0.0 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like RuvA_C PF07499.13 CCL98256.1 - 0.84 10.1 3.1 0.6 10.6 0.7 2.0 2 0 0 2 2 2 0 RuvA, C-terminal domain TFIID-18kDa PF02269.16 CCL98257.1 - 1.1e-32 111.9 0.4 2.9e-32 110.6 0.1 1.8 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Cdh1_DBD_1 PF18196.1 CCL98257.1 - 0.025 14.9 0.8 0.043 14.1 0.8 1.4 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 TFIIE-A_C PF11521.8 CCL98257.1 - 0.052 13.9 1.2 0.12 12.6 1.2 1.6 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha DUF2746 PF10874.8 CCL98257.1 - 0.11 12.9 0.1 0.23 11.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) FAA_hydrolase PF01557.18 CCL98258.1 - 3.9e-60 203.2 0.0 4.8e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family CDC14 PF08045.11 CCL98259.1 - 5.4e-33 114.3 1.0 4.1e-16 58.9 0.0 3.7 3 1 0 3 3 3 3 Cell division control protein 14, SIN component ENTH PF01417.20 CCL98259.1 - 0.064 13.3 0.2 5.2 7.1 0.1 2.3 1 1 1 2 2 2 0 ENTH domain Arb1 PF09692.10 CCL98262.1 - 2.1e-11 43.6 0.1 5.3e-11 42.3 0.1 1.8 1 1 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 VIR_N PF15912.5 CCL98262.1 - 0.036 13.7 3.4 0.12 11.9 3.4 1.9 1 0 0 1 1 1 0 Virilizer, N-terminal ATG22 PF11700.8 CCL98264.1 - 1.3e-104 350.5 22.0 1.5e-104 350.3 22.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 CCL98264.1 - 1.2e-12 47.4 34.4 5.2e-10 38.8 6.2 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Acetyltransf_1 PF00583.25 CCL98265.1 - 1.2e-09 38.4 0.0 7.9e-08 32.5 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCL98265.1 - 9.4e-08 32.4 0.0 1.8e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCL98265.1 - 1.1e-05 25.3 0.0 0.0011 18.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CCL98265.1 - 0.0033 17.4 0.0 0.0066 16.4 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase FR47 PF08445.10 CCL98265.1 - 0.0075 16.2 0.0 0.44 10.5 0.0 2.3 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CCL98265.1 - 0.02 15.5 0.0 0.064 13.9 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCL98265.1 - 0.021 14.9 0.0 0.047 13.8 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CCL98265.1 - 0.026 14.6 0.1 0.22 11.6 0.1 2.5 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCL98266.1 - 4e-09 36.8 0.0 7.2e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCL98266.1 - 6.3e-08 32.6 0.0 6.6e-06 26.1 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCL98266.1 - 4.7e-07 30.1 0.0 3.9e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_13 PF13880.6 CCL98266.1 - 0.00036 20.4 0.0 0.00084 19.3 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase FR47 PF08445.10 CCL98266.1 - 0.001 19.0 0.0 0.14 12.1 0.0 2.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 CCL98266.1 - 0.0076 16.9 0.0 0.017 15.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCL98266.1 - 0.018 15.1 0.0 0.35 11.0 0.0 2.9 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCL98266.1 - 0.036 14.2 0.0 0.092 12.9 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase WD40 PF00400.32 CCL98267.1 - 1.5e-25 88.9 11.4 0.00036 21.3 0.0 7.5 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98267.1 - 3.9e-15 55.9 0.0 0.00081 19.6 0.0 4.6 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCL98267.1 - 0.12 11.3 0.0 2.1 7.2 0.0 2.3 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CCL98267.1 - 1.8 9.1 6.3 7.4 7.2 0.1 4.0 3 2 1 4 4 4 0 PQQ-like domain RhoGEF PF00621.20 CCL98268.1 - 6.6e-35 121.0 0.0 1.5e-34 119.8 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain Cluap1 PF10234.9 CCL98268.1 - 0.051 13.0 5.0 0.077 12.4 4.0 1.8 1 1 0 1 1 1 0 Clusterin-associated protein-1 Ins_allergen_rp PF06757.13 CCL98268.1 - 0.066 13.2 0.2 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification Seryl_tRNA_N PF02403.22 CCL98268.1 - 0.11 12.7 4.4 0.95 9.7 0.8 3.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain H-kinase_dim PF02895.14 CCL98268.1 - 0.14 12.6 0.2 0.6 10.5 0.2 2.1 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain AAA_13 PF13166.6 CCL98268.1 - 0.24 10.0 2.4 0.42 9.2 1.8 1.7 1 1 0 1 1 1 0 AAA domain LMBR1 PF04791.16 CCL98268.1 - 0.36 9.7 2.2 0.68 8.8 2.2 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein SNARE PF05739.19 CCL98268.1 - 0.46 10.5 2.4 3.4 7.7 0.3 2.5 2 0 0 2 2 2 0 SNARE domain GAS PF13851.6 CCL98268.1 - 0.94 8.8 6.7 0.57 9.5 0.6 2.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spc24 PF08286.11 CCL98268.1 - 4 7.7 7.1 18 5.6 0.4 3.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 ADIP PF11559.8 CCL98268.1 - 8.5 6.4 10.3 0.21 11.7 1.0 2.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Myb_DNA-binding PF00249.31 CCL98269.1 - 0.0025 17.9 0.2 0.0025 17.9 0.2 2.4 3 0 0 3 3 3 1 Myb-like DNA-binding domain Tnp_P_element PF12017.8 CCL98269.1 - 0.1 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Transposase protein Smg8_Smg9 PF10220.9 CCL98269.1 - 5.3 5.2 9.3 7.5 4.7 9.3 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Aminotran_1_2 PF00155.21 CCL98270.1 - 2.2e-12 46.9 0.0 2.8e-10 39.9 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class I and II PH_3 PF14593.6 CCL98270.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 PH domain zf-CCHC PF00098.23 CCL98271.1 - 1.2e-09 37.8 2.3 1.2e-09 37.8 2.3 1.7 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 CCL98271.1 - 0.0056 16.6 1.8 0.0074 16.2 1.8 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 CCL98271.1 - 0.11 12.2 0.9 0.11 12.2 0.9 1.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Yae1_N PF09811.9 CCL98272.1 - 0.054 13.2 0.3 0.12 12.1 0.3 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal p450 PF00067.22 CCL98273.1 - 7.7e-64 216.1 0.0 1.6e-62 211.8 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Peptidase_S28 PF05577.12 CCL98274.1 - 1.8e-36 125.9 1.0 9.1e-36 123.6 1.0 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 CCL98274.1 - 0.0022 17.5 0.0 0.0043 16.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S28 PF05577.12 CCL98275.1 - 0.00042 19.2 0.0 0.00047 19.1 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 14-3-3 PF00244.20 CCL98276.1 - 1.6e-107 358.1 3.1 1.8e-107 357.9 3.1 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_19 PF14559.6 CCL98276.1 - 0.33 11.5 2.6 0.62 10.6 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat XkdW PF09636.10 CCL98277.1 - 0.014 15.5 0.2 0.015 15.4 0.2 1.1 1 0 0 1 1 1 0 XkdW protein DUF3618 PF12277.8 CCL98277.1 - 0.091 13.0 4.6 0.19 12.0 4.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3618) Syndecan PF01034.20 CCL98278.1 - 0.48 10.4 2.2 1.9 8.4 0.1 2.7 2 0 0 2 2 2 0 Syndecan domain AMP-binding PF00501.28 CCL98279.1 - 6.2e-62 209.6 0.0 7.7e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 CCL98280.1 - 3.4e-53 180.8 0.0 6.1e-53 180.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCL98280.1 - 1.6e-48 165.9 0.0 2.9e-48 165.0 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CCL98280.1 - 1.6e-34 119.4 0.2 2e-30 106.0 0.0 2.4 2 0 0 2 2 2 2 KR domain NAD_binding_4 PF07993.12 CCL98280.1 - 1.3e-30 106.4 0.0 2e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 CCL98280.1 - 1.8e-27 95.7 0.0 3.8e-27 94.6 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCL98280.1 - 2.9e-27 95.7 0.0 6.1e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCL98280.1 - 7.5e-12 45.7 0.0 3.9e-11 43.4 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 CCL98280.1 - 2.3e-10 40.3 0.0 4.6e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCL98280.1 - 1.8e-05 25.0 0.5 4.8e-05 23.6 0.5 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CCL98280.1 - 0.002 17.5 0.1 0.0037 16.7 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 CCL98280.1 - 0.045 12.9 0.3 0.16 11.0 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein adh_short PF00106.25 CCL98280.1 - 0.05 13.0 3.2 1.4 8.4 0.6 3.8 4 1 0 4 4 4 0 short chain dehydrogenase ACP_syn_III PF08545.10 CCL98280.1 - 0.072 13.0 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GDP_Man_Dehyd PF16363.5 CCL98280.1 - 0.11 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Rhomboid PF01694.22 CCL98281.1 - 2.1e-31 108.9 11.4 2.1e-31 108.9 11.4 2.0 2 0 0 2 2 2 1 Rhomboid family DIL PF01843.19 CCL98281.1 - 2.6e-26 91.9 0.4 5.4e-26 90.9 0.4 1.6 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 CCL98281.1 - 0.0012 19.4 0.0 0.0048 17.5 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCL98281.1 - 0.0018 18.7 3.1 0.052 14.0 0.1 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 CCL98281.1 - 0.0019 18.6 1.8 0.021 15.3 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 CCL98281.1 - 0.0047 17.2 0.1 0.11 12.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCL98281.1 - 0.049 14.2 0.1 1.2 9.8 0.0 2.8 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Rrp15p PF07890.12 CCL98282.1 - 1.4e-25 90.1 0.3 1.4e-25 90.1 0.3 2.1 1 1 1 2 2 2 1 Rrp15p CLTH PF10607.9 CCL98283.1 - 4.5e-35 120.7 0.2 5.3e-35 120.5 0.2 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCL98283.1 - 6.3e-06 26.0 0.1 1.4e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 LisH ATP-grasp_6 PF18419.1 CCL98283.1 - 0.015 15.0 0.1 0.029 14.0 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp-like domain Pkinase PF00069.25 CCL98284.1 - 3.3e-67 226.6 0.0 4.4e-67 226.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98284.1 - 1.1e-45 155.9 0.0 1.7e-45 155.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCL98284.1 - 3.4e-09 36.4 0.0 6.1e-06 25.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 CCL98284.1 - 0.0013 18.2 0.0 0.0023 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CCL98284.1 - 0.0021 16.9 0.0 0.0046 15.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Ras_bdg_2 PF14847.6 CCL98284.1 - 0.032 14.5 0.0 0.066 13.6 0.0 1.5 1 0 0 1 1 1 0 Ras-binding domain of Byr2 APH PF01636.23 CCL98284.1 - 0.049 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCL98284.1 - 0.14 11.1 0.0 0.27 10.1 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 CCL98284.1 - 0.23 10.9 0.0 0.44 10.1 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF866 PF05907.13 CCL98285.1 - 4.1e-51 172.9 0.1 4.6e-51 172.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Zn_ribbon_SprT PF17283.2 CCL98285.1 - 0.013 15.4 0.4 0.69 9.9 0.0 2.5 2 0 0 2 2 2 0 SprT-like zinc ribbon domain HalOD2 PF18547.1 CCL98285.1 - 0.61 10.0 3.1 4 7.4 0.1 2.8 3 0 0 3 3 3 0 Halobacterial output domain 2 MRP-S28 PF10213.9 CCL98286.1 - 7e-31 107.3 0.0 1.3e-30 106.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Septin PF00735.18 CCL98287.1 - 2.9e-120 400.8 0.0 2.9e-120 400.8 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CCL98287.1 - 2.6e-08 34.0 0.4 1e-07 32.0 0.0 2.2 2 1 1 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCL98287.1 - 9.1e-06 25.3 1.5 0.00086 18.9 0.0 3.1 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CCL98287.1 - 0.00018 22.0 7.0 0.013 16.0 0.6 2.6 2 1 0 2 2 2 2 ABC transporter AAA_22 PF13401.6 CCL98287.1 - 0.00026 21.3 0.0 0.0035 17.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCL98287.1 - 0.00027 20.9 0.7 0.00027 20.9 0.7 3.1 3 1 0 3 3 3 1 RsgA GTPase Ras PF00071.22 CCL98287.1 - 0.0026 17.4 0.0 0.014 15.0 0.0 2.2 2 1 1 3 3 3 1 Ras family Roc PF08477.13 CCL98287.1 - 0.0046 17.2 0.0 0.014 15.6 0.0 1.8 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 CCL98287.1 - 0.0048 16.2 1.3 0.0063 15.9 0.0 1.8 2 0 0 2 2 2 1 AIG1 family AAA_16 PF13191.6 CCL98287.1 - 0.012 16.0 0.1 0.041 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 CCL98287.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 CCL98287.1 - 0.018 15.1 4.7 0.023 14.8 0.1 2.8 2 1 0 2 2 2 0 Dynamin family Exonuc_VII_L PF02601.15 CCL98287.1 - 0.42 10.1 3.3 0.7 9.4 3.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATP_bind_1 PF03029.17 CCL98287.1 - 0.43 10.3 7.4 1.7 8.4 0.0 3.5 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Strep_SA_rep PF06696.11 CCL98287.1 - 3.1 7.9 11.6 0.34 10.9 3.9 2.5 1 1 1 2 2 2 0 Streptococcal surface antigen repeat Xpo1 PF08389.12 CCL98288.1 - 1.8e-22 80.0 0.0 2.8e-21 76.1 0.0 3.0 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 CCL98288.1 - 4.2e-05 23.4 0.0 0.00037 20.4 0.0 2.5 2 1 1 3 3 3 1 Importin-beta N-terminal domain CoA_binding PF02629.19 CCL98289.1 - 5.4e-30 103.9 0.1 1.1e-29 102.9 0.1 1.6 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 CCL98289.1 - 4.5e-24 85.0 0.1 7.3e-24 84.3 0.1 1.3 1 0 0 1 1 1 1 CoA-ligase Ank_5 PF13857.6 CCL98289.1 - 1e-15 57.6 0.7 2.3e-15 56.4 0.7 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) ACBP PF00887.19 CCL98289.1 - 3.4e-13 49.6 0.0 6.6e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_4 PF13637.6 CCL98289.1 - 7.1e-12 45.6 0.1 4.4e-08 33.5 0.0 2.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCL98289.1 - 4.3e-10 40.1 0.3 2.1e-09 37.8 0.1 2.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCL98289.1 - 2.5e-09 37.1 0.2 3.3e-08 33.6 0.1 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 CCL98289.1 - 9.2e-09 34.9 0.2 6.1e-07 29.3 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Succ_CoA_lig PF13607.6 CCL98289.1 - 2e-06 27.7 0.0 4.7e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CCL98289.1 - 0.037 14.5 0.2 0.14 12.7 0.1 2.0 1 1 1 2 2 2 0 CoA binding domain Ribosomal_S16 PF00886.19 CCL98290.1 - 5e-20 71.3 0.1 6.9e-20 70.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 Arm PF00514.23 CCL98291.1 - 7.3e-91 295.8 12.7 4.1e-12 45.7 0.1 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 CCL98291.1 - 1.3e-23 83.2 1.0 5.4e-23 81.3 1.7 1.7 2 0 0 2 2 1 1 Importin beta binding domain HEAT_EZ PF13513.6 CCL98291.1 - 5.3e-22 77.9 3.5 2.5e-08 34.2 0.1 6.0 2 1 4 6 6 6 4 HEAT-like repeat Arm_3 PF16186.5 CCL98291.1 - 5.4e-21 73.9 0.8 1.2e-20 72.8 0.8 1.6 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_2 PF13646.6 CCL98291.1 - 2.8e-19 69.3 0.1 6.8e-06 26.4 0.0 5.2 1 1 5 6 6 6 5 HEAT repeats LSM PF01423.22 CCL98291.1 - 9.5e-18 63.7 0.0 1.8e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 LSM domain HEAT PF02985.22 CCL98291.1 - 3.5e-16 57.9 0.2 0.00055 20.0 0.0 6.4 6 0 0 6 6 6 4 HEAT repeat Adaptin_N PF01602.20 CCL98291.1 - 1.4e-05 23.9 0.0 0.0025 16.4 0.0 2.9 1 1 1 2 2 2 1 Adaptin N terminal region RICTOR_V PF14668.6 CCL98291.1 - 0.00014 22.0 1.6 0.1 12.8 0.0 4.1 3 2 2 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 CCL98291.1 - 0.00043 19.8 0.0 2.6 7.4 0.0 3.7 2 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 CCL98291.1 - 0.00047 20.3 0.0 2.7 8.1 0.0 4.1 3 2 1 4 4 4 2 V-ATPase subunit H Mo25 PF08569.11 CCL98291.1 - 0.00076 18.9 0.0 0.0017 17.8 0.0 1.5 1 0 0 1 1 1 1 Mo25-like HEAT_PBS PF03130.16 CCL98291.1 - 0.0015 19.1 0.8 0.74 10.7 0.1 4.3 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat V-ATPase_H_N PF03224.14 CCL98291.1 - 0.11 11.7 0.0 7.3 5.8 0.0 3.0 1 1 1 2 2 2 0 V-ATPase subunit H RPN2_C PF18004.1 CCL98292.1 - 1.2e-42 145.5 2.7 1.9e-41 141.6 2.1 2.2 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 CCL98292.1 - 1.5e-34 116.7 25.0 3.1e-08 33.6 0.0 8.9 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CCL98292.1 - 1.6e-19 70.1 2.8 1.7e-14 53.9 0.0 5.0 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.22 CCL98292.1 - 5.6e-06 26.2 0.2 2.7 8.5 0.1 5.0 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 CCL98292.1 - 0.013 15.9 7.1 1.2 9.7 0.0 5.4 4 1 2 6 6 6 0 HEAT-like repeat ANAPC3 PF12895.7 CCL98292.1 - 0.044 14.0 0.5 0.28 11.4 0.4 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 CCL98292.1 - 0.43 9.4 2.7 0.56 9.1 1.5 1.8 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 CCL98292.1 - 1.6 9.1 5.6 1.7 8.9 0.7 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat COX6A PF02046.15 CCL98293.1 - 7e-27 94.1 0.2 8.5e-27 93.9 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa DUF2771 PF10969.8 CCL98293.1 - 0.035 14.1 0.1 0.15 12.1 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2771) VBS PF08913.10 CCL98294.1 - 0.0082 16.6 0.5 0.015 15.8 0.5 1.5 1 0 0 1 1 1 1 Vinculin Binding Site ThylakoidFormat PF11264.8 CCL98294.1 - 0.21 11.3 0.0 0.25 11.0 0.0 1.1 1 0 0 1 1 1 0 Thylakoid formation protein YiiD_C PF09500.10 CCL98294.1 - 0.23 11.3 4.1 13 5.6 0.2 3.1 2 1 1 3 3 3 0 Putative thioesterase (yiiD_Cterm) Ribul_P_3_epim PF00834.19 CCL98295.1 - 1.1e-30 106.5 0.0 1.5e-25 89.7 0.1 2.0 1 1 1 2 2 2 2 Ribulose-phosphate 3 epimerase family PG_binding_3 PF09374.10 CCL98295.1 - 0.16 12.2 0.0 0.32 11.3 0.0 1.6 2 0 0 2 2 2 0 Predicted Peptidoglycan domain PK PF00224.21 CCL98296.1 - 3.7e-154 512.8 0.6 4.9e-154 512.4 0.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CCL98296.1 - 5e-36 123.5 0.0 9.3e-36 122.6 0.0 1.5 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain Gly_transf_sug PF04488.15 CCL98296.1 - 0.00011 22.8 0.0 0.0003 21.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif HpcH_HpaI PF03328.14 CCL98296.1 - 0.0016 17.6 0.2 0.0029 16.8 0.2 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family LAG1-DNAbind PF09271.11 CCL98297.1 - 6.7e-27 95.0 2.1 2.1e-16 60.9 0.1 2.8 2 1 1 3 3 3 2 LAG1, DNA binding BTD PF09270.10 CCL98297.1 - 5.6e-26 91.6 0.0 1.2e-25 90.5 0.0 1.6 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain DUF4203 PF13886.6 CCL98299.1 - 4.5e-51 173.4 31.0 4.5e-51 173.4 31.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4203) V_ATPase_I PF01496.19 CCL98299.1 - 0.43 8.4 3.7 0.83 7.5 3.7 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Miga PF10265.9 CCL98299.1 - 4.3 6.2 6.3 13 4.6 6.3 1.8 1 0 0 1 1 1 0 Mitoguardin DEAD PF00270.29 CCL98300.1 - 3.2e-19 69.3 0.0 5.7e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCL98300.1 - 1.6e-07 31.7 0.0 1.2e-06 28.8 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCL98300.1 - 0.024 14.7 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.6 CCL98300.1 - 0.034 13.5 0.0 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Sugar_tr PF00083.24 CCL98301.1 - 2.3e-107 359.7 11.1 2.7e-107 359.5 11.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCL98301.1 - 1.7e-34 119.3 40.6 3.1e-28 98.7 20.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PPR_2 PF13041.6 CCL98303.1 - 2.5e-47 158.8 0.2 7.7e-08 32.4 0.0 9.9 5 4 5 10 10 10 9 PPR repeat family PPR_3 PF13812.6 CCL98303.1 - 3.1e-29 100.8 0.0 3.2e-07 30.3 0.0 6.1 5 1 1 6 6 6 5 Pentatricopeptide repeat domain PPR PF01535.20 CCL98303.1 - 5.6e-21 73.3 1.1 0.0034 17.5 0.0 9.9 11 1 0 11 11 11 5 PPR repeat PPR_1 PF12854.7 CCL98303.1 - 7.7e-18 63.9 3.4 0.086 12.6 0.0 10.0 10 0 0 10 10 10 6 PPR repeat PPR_long PF17177.4 CCL98303.1 - 3.5e-08 33.1 0.0 0.0037 16.6 0.0 4.1 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 CCL98303.1 - 0.046 14.1 0.1 16 5.9 0.0 3.3 2 1 0 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) RabGAP-TBC PF00566.18 CCL98303.1 - 0.13 11.9 0.1 20 4.7 0.1 2.4 2 0 0 2 2 2 0 Rab-GTPase-TBC domain Pro_isomerase PF00160.21 CCL98304.1 - 5.5e-45 153.5 0.0 8.5e-45 152.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 CCL98304.1 - 0.024 14.0 0.2 0.24 10.8 0.0 2.3 2 1 0 2 2 2 0 Rtf2 RING-finger zf-NOSIP PF15906.5 CCL98304.1 - 0.025 14.7 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein FMO-like PF00743.19 CCL98306.1 - 8e-11 41.1 0.1 2.2e-07 29.7 0.1 2.8 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCL98306.1 - 2.8e-08 33.8 0.0 6.3e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCL98306.1 - 2.3e-05 23.8 0.0 0.0075 15.5 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCL98306.1 - 0.00098 18.4 0.1 0.083 12.0 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCL98306.1 - 0.033 13.4 1.6 14 4.8 0.0 3.4 3 2 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase GerD PF17898.1 CCL98306.1 - 0.041 13.8 0.4 0.093 12.7 0.4 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain HI0933_like PF03486.14 CCL98306.1 - 0.14 10.8 0.1 0.23 10.1 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 CCL98306.1 - 0.17 11.1 0.0 0.38 10.0 0.0 1.5 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 CCL98306.1 - 0.17 11.4 2.5 3.5 7.1 2.5 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase PARP PF00644.20 CCL98307.1 - 2.8e-15 56.4 0.3 1.2e-12 47.9 0.3 2.8 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF4470 PF14737.6 CCL98308.1 - 2.1e-24 85.5 0.1 3.8e-24 84.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 CCL98308.1 - 0.00053 20.0 12.7 0.1 12.7 4.2 2.7 2 0 0 2 2 2 2 MYND finger Dabb PF07876.12 CCL98308.1 - 0.13 12.9 0.1 7.3 7.3 0.0 2.6 2 0 0 2 2 2 0 Stress responsive A/B Barrel Domain MacB_PCD PF12704.7 CCL98309.1 - 0.039 14.3 0.1 0.044 14.1 0.1 1.2 1 0 0 1 1 1 0 MacB-like periplasmic core domain DUF4470 PF14737.6 CCL98311.1 - 1.3e-24 86.3 0.1 3.2e-24 85.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 CCL98311.1 - 1.7e-09 37.6 12.2 3.6e-09 36.6 12.2 1.5 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 CCL98311.1 - 0.047 14.0 7.9 0.093 13.0 7.9 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-HIT PF04438.16 CCL98311.1 - 0.64 9.9 7.8 1.2 9.0 7.8 1.5 1 0 0 1 1 1 0 HIT zinc finger DUF2085 PF09858.9 CCL98312.1 - 0.37 11.3 4.2 0.67 10.5 0.1 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2085) E1-E2_ATPase PF00122.20 CCL98313.1 - 1.2e-40 139.0 0.8 1.2e-40 139.0 0.8 2.4 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCL98313.1 - 5.2e-30 104.5 3.7 5.2e-30 104.5 3.7 3.1 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCL98313.1 - 4.7e-21 76.0 2.5 3.8e-10 40.4 0.4 3.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCL98313.1 - 2.2e-18 66.1 0.0 7.7e-18 64.4 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCL98313.1 - 3.4e-09 36.3 0.0 6.7e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCL98313.1 - 1.4e-07 31.5 0.4 2.7e-07 30.6 0.4 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCL98313.1 - 1.4e-05 25.6 0.3 0.005 17.3 0.0 3.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase F-box-like PF12937.7 CCL98314.1 - 1.4e-07 31.3 0.1 4.7e-07 29.6 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCL98314.1 - 0.0091 15.9 0.0 0.032 14.1 0.0 1.9 1 0 0 1 1 1 1 F-box domain Fez1 PF06818.15 CCL98315.1 - 2.4 8.6 90.4 0.16 12.4 22.5 5.5 1 1 1 3 3 3 0 Fez1 Pkinase_fungal PF17667.1 CCL98316.1 - 4.1e-64 216.8 0.1 5.2e-64 216.5 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCL98316.1 - 8.9e-10 38.4 0.0 1.7e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98316.1 - 1.8e-06 27.5 0.0 2.1e-05 23.9 0.0 2.3 3 0 0 3 3 3 1 Protein tyrosine kinase APH PF01636.23 CCL98316.1 - 0.0037 17.2 0.4 0.093 12.6 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCL98316.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box PF00646.33 CCL98317.1 - 0.0092 15.8 0.4 0.022 14.6 0.4 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCL98317.1 - 0.071 13.0 1.4 0.11 12.4 0.3 1.9 2 0 0 2 2 2 0 F-box-like DUF4470 PF14737.6 CCL98318.1 - 7.6e-22 77.3 0.2 1.4e-21 76.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Ycf1 PF05758.12 CCL98319.1 - 0.059 11.2 1.6 0.063 11.2 1.6 1.0 1 0 0 1 1 1 0 Ycf1 DUF4470 PF14737.6 CCL98321.1 - 6.9e-24 83.9 0.1 1.2e-23 83.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) MFS_1 PF07690.16 CCL98322.1 - 2.6e-45 154.9 28.7 4.1e-45 154.2 28.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCL98322.1 - 1.2e-13 50.8 4.7 1.2e-13 50.8 4.7 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter Atg14 PF10186.9 CCL98323.1 - 8.4e-30 103.9 0.0 2.8e-29 102.2 0.0 1.7 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Dynamin_M PF01031.20 CCL98324.1 - 3.1e-34 118.5 0.0 1.1e-33 116.7 0.0 1.9 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CCL98324.1 - 1.2e-27 97.0 0.0 2.9e-27 95.7 0.0 1.7 1 1 0 1 1 1 1 Dynamin family GED PF02212.18 CCL98324.1 - 8e-09 35.5 0.0 3.4e-08 33.5 0.0 2.1 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCL98324.1 - 4.2e-05 23.6 0.0 0.00019 21.5 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCL98324.1 - 0.017 15.5 0.1 0.35 11.2 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 CCL98324.1 - 0.03 14.1 0.0 0.073 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CCL98324.1 - 0.062 13.8 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter But2 PF09792.9 CCL98325.1 - 5.5e-05 23.6 0.1 8.8e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain RNase_H PF00075.24 CCL98327.1 - 3.3e-08 33.8 0.0 8.6e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 CCL98327.1 - 0.17 11.7 0.1 1.4 8.8 0.1 2.3 1 1 1 2 2 2 0 Reverse transcriptase-like CCDC168_N PF15804.5 CCL98328.1 - 0.00026 20.9 0.0 0.00031 20.7 0.0 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 168 MIP PF00230.20 CCL98329.1 - 3e-42 144.9 17.5 3.9e-42 144.5 17.5 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF3188 PF11384.8 CCL98329.1 - 0.36 10.6 3.9 3 7.6 0.3 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) eIF-5_eIF-2B PF01873.17 CCL98330.1 - 9.8e-40 135.1 0.0 1.9e-39 134.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 CCL98330.1 - 3.4e-22 78.4 1.1 3.1e-20 72.1 0.2 2.6 2 0 0 2 2 2 2 eIF4-gamma/eIF5/eIF2-epsilon DNA_methylase PF00145.17 CCL98331.1 - 4.2e-17 62.5 0.0 5.7e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase PHD PF00628.29 CCL98332.1 - 7.5e-12 45.0 4.4 1.3e-11 44.2 4.4 1.4 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 CCL98332.1 - 0.18 11.9 2.9 0.42 10.7 2.6 1.8 2 0 0 2 2 2 0 PHD-finger PHD_2 PF13831.6 CCL98332.1 - 0.25 10.9 2.2 0.47 10.1 2.2 1.4 1 0 0 1 1 1 0 PHD-finger zf-PHD-like PF15446.6 CCL98332.1 - 0.29 10.8 0.7 0.57 9.8 0.7 1.4 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain FXR_C1 PF16096.5 CCL98332.1 - 5.9 7.2 9.6 0.15 12.2 2.2 2.2 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 GAS PF13851.6 CCL98333.1 - 0.05 12.9 0.4 0.079 12.3 0.4 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Mei4 PF13971.6 CCL98333.1 - 0.13 11.8 0.1 0.18 11.3 0.1 1.2 1 0 0 1 1 1 0 Meiosis-specific protein Mei4 FYVE PF01363.21 CCL98334.1 - 1e-18 67.2 5.5 1.8e-18 66.4 5.5 1.4 1 0 0 1 1 1 1 FYVE zinc finger NAD_binding_10 PF13460.6 CCL98335.1 - 6.5e-05 22.9 0.0 0.00011 22.2 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding p450 PF00067.22 CCL98337.1 - 2e-79 267.5 0.0 2.5e-79 267.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Reticulon PF02453.17 CCL98337.1 - 0.012 15.5 0.1 0.3 11.0 0.0 2.3 2 0 0 2 2 2 0 Reticulon p450 PF00067.22 CCL98338.1 - 2.3e-76 257.4 0.0 2.8e-76 257.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Reticulon PF02453.17 CCL98338.1 - 0.045 13.7 0.3 0.091 12.7 0.0 1.7 2 0 0 2 2 2 0 Reticulon p450 PF00067.22 CCL98339.1 - 5.3e-15 55.1 0.1 6.8e-15 54.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAM176 PF14851.6 CCL98339.1 - 0.061 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 FAM176 family Oxysterol_BP PF01237.18 CCL98340.1 - 6.9e-82 275.2 0.0 1.3e-79 267.8 0.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein YmaF PF12788.7 CCL98341.1 - 0.017 15.7 0.0 0.02 15.4 0.0 1.1 1 0 0 1 1 1 0 YmaF family DUF4553 PF15090.6 CCL98341.1 - 0.091 11.7 0.0 0.12 11.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4553) PAM2 PF07145.15 CCL98342.1 - 0.00091 18.8 13.0 0.64 9.8 0.1 4.8 4 0 0 4 4 4 2 Ataxin-2 C-terminal region Shugoshin_N PF07558.11 CCL98342.1 - 0.0014 18.4 3.1 0.64 9.9 0.3 3.4 3 0 0 3 3 3 2 Shugoshin N-terminal coiled-coil region Surfac_D-trimer PF09006.11 CCL98342.1 - 0.18 11.7 0.3 0.53 10.2 0.3 1.8 1 0 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation DUF4715 PF15835.5 CCL98342.1 - 0.19 11.8 5.8 0.031 14.4 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4715) Vac_Fusion PF02346.16 CCL98342.1 - 1.3 8.8 3.0 20 4.9 0.0 3.4 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 TSC22 PF01166.18 CCL98342.1 - 1.4 9.3 8.7 1.4 9.2 0.0 4.0 4 0 0 4 4 4 0 TSC-22/dip/bun family Syntaxin-18_N PF10496.9 CCL98342.1 - 2.6 8.4 5.4 1.7 8.9 0.1 3.2 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus Nic96 PF04097.14 CCL98344.1 - 5.6e-147 490.9 0.0 7e-147 490.5 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 DUF4096 PF13340.6 CCL98344.1 - 0.025 14.8 1.0 0.72 10.1 0.1 3.5 3 1 0 4 4 4 0 Putative transposase of IS4/5 family (DUF4096) MCM PF00493.23 CCL98347.1 - 1.4e-99 331.8 0.0 2.1e-99 331.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCL98347.1 - 5.4e-38 129.7 0.0 9.2e-38 128.9 0.0 1.3 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 CCL98347.1 - 3.4e-32 111.8 34.2 4.8e-32 111.4 32.0 2.3 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 CCL98347.1 - 1.2e-25 89.8 1.4 2.5e-25 88.7 0.5 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 CCL98347.1 - 2.6e-13 50.4 0.0 7.6e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCL98347.1 - 1.3e-07 31.2 0.0 3.3e-06 26.6 0.0 2.3 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCL98347.1 - 1.4e-05 25.1 0.0 3.1e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CCL98347.1 - 0.00039 20.3 0.0 0.021 14.7 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCL98347.1 - 0.0046 16.7 0.1 0.035 13.8 0.1 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain SelR PF01641.18 CCL98347.1 - 0.0057 16.7 0.2 5.8 7.0 0.0 2.5 2 0 0 2 2 2 2 SelR domain Yippee-Mis18 PF03226.14 CCL98347.1 - 0.033 14.4 0.0 0.069 13.4 0.0 1.4 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ABC_tran PF00005.27 CCL98348.1 - 4.3e-34 118.0 0.0 7.8e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CCL98348.1 - 1.8e-31 109.8 12.2 3.1e-31 109.0 12.2 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CCL98348.1 - 0.00048 19.6 0.0 0.0044 16.5 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCL98348.1 - 0.00059 20.3 0.3 0.0021 18.5 0.3 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCL98348.1 - 0.0037 17.5 0.0 0.053 13.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CCL98348.1 - 0.0097 15.7 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CCL98348.1 - 0.011 15.5 0.1 0.029 14.2 0.0 1.7 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CCL98348.1 - 0.012 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 CCL98348.1 - 0.013 15.3 0.2 0.032 14.0 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Flavi_M PF01004.19 CCL98348.1 - 0.025 14.3 0.0 0.073 12.8 0.0 1.7 1 0 0 1 1 1 0 Flavivirus envelope glycoprotein M AAA_25 PF13481.6 CCL98348.1 - 0.03 13.9 0.1 0.88 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCL98348.1 - 0.13 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin APS_kinase PF01583.20 CCL98348.1 - 0.16 11.8 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase RRM_1 PF00076.22 CCL98349.1 - 1.6e-10 40.7 0.0 2.3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BMC PF00936.19 CCL98351.1 - 0.14 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 BMC domain F-box-like PF12937.7 CCL98354.1 - 0.1 12.5 0.9 0.27 11.2 0.9 1.7 1 1 0 1 1 1 0 F-box-like Pentapeptide_4 PF13599.6 CCL98354.1 - 0.13 12.5 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Med14 PF08638.11 CCL98355.1 - 3.1e-58 196.4 0.4 8.5e-58 194.9 0.4 1.8 1 0 0 1 1 1 1 Mediator complex subunit MED14 HEAT PF02985.22 CCL98356.1 - 5.1e-07 29.4 0.0 1.5 9.3 0.0 5.4 4 0 0 4 4 4 2 HEAT repeat Pkinase PF00069.25 CCL98356.1 - 5.7e-07 29.2 0.0 1.4e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Cnd1 PF12717.7 CCL98356.1 - 0.0001 22.4 0.1 0.0069 16.4 0.0 2.4 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCL98356.1 - 0.00099 19.4 0.0 1.1 9.7 0.0 3.6 3 1 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 CCL98356.1 - 0.0013 19.2 0.4 4.3 7.9 0.0 3.9 3 1 1 4 4 4 2 HEAT-like repeat Kinase-like PF14531.6 CCL98356.1 - 0.012 14.9 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Pkinase_Tyr PF07714.17 CCL98356.1 - 0.033 13.5 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase DASH_Dad2 PF08654.10 CCL98357.1 - 4.6e-07 30.2 0.1 9e-07 29.2 0.1 1.5 1 1 0 1 1 1 1 DASH complex subunit Dad2 Peptidase_C25 PF01364.18 CCL98357.1 - 0.0083 15.4 0.0 0.0098 15.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C25 DUF1178 PF06676.11 CCL98357.1 - 0.024 15.1 0.3 0.033 14.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) HHH_2 PF12826.7 CCL98357.1 - 0.11 12.6 0.5 0.2 11.8 0.5 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF745 PF05335.13 CCL98358.1 - 0.06 13.1 2.2 0.14 11.8 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF745) GST_N_2 PF13409.6 CCL98359.1 - 3e-12 46.6 0.0 6.4e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCL98359.1 - 3.1e-12 46.7 0.0 8.5e-12 45.3 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCL98359.1 - 0.00027 20.9 0.2 0.00027 20.9 0.2 1.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCL98359.1 - 0.0055 16.9 0.0 0.0084 16.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCL98359.1 - 0.018 15.4 0.0 10 6.6 0.0 2.3 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCL98359.1 - 0.024 14.8 0.0 0.092 12.9 0.0 2.0 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CCL98359.1 - 0.066 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Abhydrolase_3 PF07859.13 CCL98360.1 - 3.4e-15 56.5 1.9 6.7e-15 55.5 1.9 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCL98360.1 - 0.00074 18.5 0.0 0.0036 16.2 0.0 2.0 2 1 0 2 2 2 1 Steryl acetyl hydrolase DLH PF01738.18 CCL98360.1 - 0.018 14.6 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 CCL98360.1 - 1.6 9.2 22.3 2.5 8.6 22.4 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family PEPCK_ATP PF01293.20 CCL98361.1 - 8.8e-218 723.6 0.0 1e-217 723.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase ABC_tran PF00005.27 CCL98361.1 - 0.064 13.8 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 CCL98361.1 - 0.095 12.5 0.1 0.27 11.0 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CCL98361.1 - 0.12 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rota_NSP4 PF01452.16 CCL98362.1 - 0.0014 18.3 2.6 0.038 13.7 1.8 2.3 2 0 0 2 2 2 1 Rotavirus non structural protein TPPK_C PF12555.8 CCL98362.1 - 1.7 8.8 8.2 0.1 12.7 1.0 2.6 2 1 1 3 3 3 0 Thiamine pyrophosphokinase C terminal Cadherin_C_2 PF16492.5 CCL98362.1 - 3.1 8.6 7.9 5 7.9 0.8 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal adh_short PF00106.25 CCL98363.1 - 4.1e-33 114.5 0.1 6.9e-33 113.8 0.1 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL98363.1 - 1.2e-31 110.0 0.8 3.1e-31 108.7 0.8 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL98363.1 - 3.2e-07 30.4 0.3 3.8e-05 23.7 0.2 2.3 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 CCL98363.1 - 0.00019 20.9 0.2 0.00031 20.3 0.2 1.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family TF_Zn_Ribbon PF08271.12 CCL98364.1 - 0.078 12.5 5.5 0.35 10.4 0.3 2.6 3 0 0 3 3 3 0 TFIIB zinc-binding Palm_thioest PF02089.15 CCL98365.1 - 5.3e-81 272.0 0.0 6.2e-81 271.8 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 CCL98365.1 - 0.00064 19.4 1.0 0.013 15.1 1.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold NAD_binding_9 PF13454.6 CCL98366.1 - 0.00065 19.7 0.0 0.0019 18.2 0.0 1.8 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCL98366.1 - 0.0017 17.7 0.0 0.18 11.0 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase CybS PF05328.12 CCL98367.1 - 7.2e-33 113.1 0.2 4.8e-32 110.4 0.2 1.9 1 1 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Dynamin_M PF01031.20 CCL98368.1 - 6.5e-33 114.2 0.0 2.8e-31 108.8 0.0 2.3 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CCL98368.1 - 2e-18 67.0 0.0 7.8e-18 65.1 0.0 2.0 1 1 0 1 1 1 1 Dynamin family GED PF02212.18 CCL98368.1 - 1.3e-10 41.3 1.3 3.1e-10 40.1 0.5 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCL98368.1 - 4e-06 26.9 0.2 7.6e-05 22.8 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 CCL98368.1 - 0.015 15.5 0.1 0.035 14.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCL98368.1 - 0.041 14.4 0.0 0.21 12.1 0.0 2.2 2 0 0 2 2 2 0 ABC transporter Cadherin_4 PF17803.1 CCL98368.1 - 0.11 13.2 3.4 5.4 7.7 0.2 2.5 2 0 0 2 2 2 0 Bacterial cadherin-like domain AAA_29 PF13555.6 CCL98368.1 - 0.21 11.3 0.3 0.49 10.2 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1857 PF08982.11 CCL98369.1 - 2.6e-36 124.6 0.0 3e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1857) Aldo_ket_red PF00248.21 CCL98370.1 - 9.1e-46 156.4 0.0 9.6e-44 149.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 CCL98371.1 - 8.4e-41 140.1 0.0 2e-38 132.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family COX7C PF02935.16 CCL98372.1 - 3.8e-16 59.1 0.8 4.2e-16 58.9 0.8 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc APH PF01636.23 CCL98373.1 - 4.4e-20 72.6 0.0 7.5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CCL98373.1 - 0.00011 21.6 0.5 0.00016 21.1 0.0 1.5 2 0 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 CCL98373.1 - 0.0011 17.9 0.0 0.0019 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 CCL98373.1 - 0.0034 17.0 0.1 0.0087 15.7 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase Lipase_GDSL_2 PF13472.6 CCL98375.1 - 2e-10 41.4 0.1 6.9e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCL98375.1 - 0.0002 21.4 0.0 0.00039 20.4 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ARD PF03079.14 CCL98377.1 - 2.2e-41 141.7 0.0 2.5e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 CCL98377.1 - 5e-09 35.7 0.5 1e-08 34.8 0.5 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CCL98377.1 - 1.5e-07 31.4 0.2 2.1e-07 30.9 0.2 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 CCL98377.1 - 0.0037 16.9 0.0 0.0061 16.2 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 CCL98377.1 - 0.019 14.7 0.1 0.047 13.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF861) DUF3337 PF11816.8 CCL98378.1 - 4.9e-52 176.3 0.0 9.1e-52 175.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) MFS_1 PF07690.16 CCL98378.1 - 9.7e-32 110.2 28.3 1.5e-31 109.6 28.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily WD40 PF00400.32 CCL98378.1 - 3e-22 78.5 13.6 9.1e-07 29.5 1.0 7.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98378.1 - 0.0045 17.3 0.0 0.21 11.9 0.0 3.1 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 CCL98378.1 - 0.013 14.5 0.2 2.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 CCL98378.1 - 0.015 14.0 0.3 2.3 6.8 0.1 2.6 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCL98378.1 - 0.023 13.7 0.0 0.27 10.2 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RAWUL PF16207.5 CCL98378.1 - 0.098 13.3 0.0 0.2 12.3 0.0 1.5 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like GvpO PF05800.11 CCL98378.1 - 0.13 12.3 0.4 0.35 10.9 0.4 1.7 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpO PCI PF01399.27 CCL98379.1 - 7.2e-08 32.9 3.5 1.7e-06 28.5 0.0 3.3 3 0 0 3 3 3 2 PCI domain Ion_trans PF00520.31 CCL98380.1 - 5.4e-113 376.2 89.4 1.7e-35 122.4 11.2 5.1 5 0 0 5 5 5 5 Ion transport protein PKD_channel PF08016.12 CCL98380.1 - 2.9 6.5 62.0 0.12 11.0 6.2 7.2 5 2 1 7 7 7 0 Polycystin cation channel Ubiq_cyt_C_chap PF03981.12 CCL98381.1 - 3.7e-23 82.2 0.1 1.9e-12 47.4 0.0 3.1 2 1 0 2 2 2 2 Ubiquinol-cytochrome C chaperone Cdd1 PF11731.8 CCL98381.1 - 0.046 14.0 0.0 0.099 12.9 0.0 1.5 1 0 0 1 1 1 0 Pathogenicity locus PI3Ka PF00613.20 CCL98382.1 - 3.6e-55 186.2 0.1 7.9e-55 185.1 0.1 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 CCL98382.1 - 1.5e-44 152.7 0.0 1.3e-29 103.8 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 CCL98382.1 - 1.1e-40 138.8 0.0 1.8e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 p450 PF00067.22 CCL98383.1 - 3.2e-66 224.0 0.0 1.3e-65 222.0 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCL98383.1 - 0.0029 16.6 0.2 0.0043 16.0 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) GTP_cyclohydroI PF01227.22 CCL98383.1 - 0.17 11.3 0.0 0.37 10.2 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase I DUF1295 PF06966.12 CCL98384.1 - 3.9e-35 121.5 12.3 2.9e-34 118.6 12.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCL98384.1 - 0.049 14.0 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Sde2_N_Ubi PF13019.6 CCL98385.1 - 3.2e-54 183.2 0.0 5.5e-54 182.4 0.0 1.4 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain HD PF01966.22 CCL98386.1 - 0.0002 21.6 0.0 0.00033 20.9 0.0 1.5 1 1 0 1 1 1 1 HD domain Mito_fiss_reg PF05308.11 CCL98387.1 - 0.034 14.2 0.5 0.065 13.3 0.0 1.6 1 1 1 2 2 2 0 Mitochondrial fission regulator F-box-like PF12937.7 CCL98388.1 - 2.6e-07 30.4 0.5 6.9e-07 29.1 0.5 1.8 1 0 0 1 1 1 1 F-box-like LPP PF04728.13 CCL98389.1 - 0.028 14.8 0.4 0.028 14.8 0.4 2.3 3 0 0 3 3 2 0 Lipoprotein leucine-zipper CEP63 PF17045.5 CCL98389.1 - 0.04 13.8 0.4 0.17 11.8 0.1 1.9 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa NPV_P10 PF05531.12 CCL98389.1 - 0.04 14.4 1.1 2 8.9 1.7 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.6 CCL98389.1 - 0.046 14.2 1.3 0.22 12.0 0.1 2.5 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Sec2p PF06428.11 CCL98389.1 - 0.064 13.2 2.6 9.5 6.3 0.0 2.6 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Fer4_24 PF18109.1 CCL98389.1 - 0.085 13.2 1.0 2.4 8.5 0.6 2.5 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain FlxA PF14282.6 CCL98389.1 - 0.11 12.5 3.5 0.51 10.4 0.4 2.4 2 0 0 2 2 2 0 FlxA-like protein DivIC PF04977.15 CCL98389.1 - 0.11 12.3 0.9 6.8 6.5 0.9 2.4 2 0 0 2 2 2 0 Septum formation initiator Spc7 PF08317.11 CCL98389.1 - 0.11 11.4 0.2 1.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein FlgN PF05130.12 CCL98389.1 - 0.14 12.7 0.9 4.4 7.8 0.1 2.4 2 0 0 2 2 2 0 FlgN protein DUF5320 PF17253.2 CCL98389.1 - 0.19 12.8 0.1 0.52 11.4 0.0 1.8 2 0 0 2 2 1 0 Family of unknown function (DUF5320) Lipoprotein_20 PF13942.6 CCL98389.1 - 0.5 10.3 2.1 0.64 9.9 0.6 1.9 2 0 0 2 2 1 0 YfhG lipoprotein MscS_porin PF12795.7 CCL98389.1 - 0.56 9.7 5.5 3.3 7.2 1.3 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain SlyX PF04102.12 CCL98389.1 - 0.56 10.9 7.2 0.33 11.6 0.5 3.6 3 1 0 3 3 3 0 SlyX Matrilin_ccoil PF10393.9 CCL98389.1 - 0.72 9.8 3.5 0.74 9.7 1.4 2.0 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin TMF_DNA_bd PF12329.8 CCL98389.1 - 1 9.4 5.4 2.1 8.4 0.9 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF4200 PF13863.6 CCL98389.1 - 1.4 9.4 4.6 5.6 7.4 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DUF4763 PF15960.5 CCL98389.1 - 3.5 6.8 5.6 12 5.1 1.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) DHR10 PF18595.1 CCL98389.1 - 5 7.2 8.6 0.23 11.5 0.7 2.7 4 0 0 4 4 3 0 Designed helical repeat protein 10 domain ZapB PF06005.12 CCL98389.1 - 7.1 7.2 9.3 0.5 10.8 1.0 3.0 4 0 0 4 4 4 0 Cell division protein ZapB F-box-like PF12937.7 CCL98390.1 - 5.8e-06 26.1 5.8 0.00023 21.0 5.8 3.2 1 1 0 1 1 1 1 F-box-like NUDIX PF00293.28 CCL98392.1 - 8.2e-12 45.3 0.0 1.4e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain SMP PF04927.12 CCL98392.1 - 0.021 15.3 4.2 0.34 11.4 1.1 2.4 2 0 0 2 2 2 0 Seed maturation protein Aminotran_3 PF00202.21 CCL98393.1 - 3.6e-38 131.3 0.0 4.2e-20 71.8 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-III AAA_26 PF13500.6 CCL98393.1 - 6.4e-20 71.8 0.0 1.2e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain MobB PF03205.14 CCL98393.1 - 0.089 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IlvN PF07991.12 CCL98394.1 - 5.3e-46 156.2 0.0 8.2e-46 155.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CCL98394.1 - 9.8e-36 123.2 0.0 1.7e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain MARVEL PF01284.23 CCL98395.1 - 2.2e-09 37.5 10.8 3.4e-09 36.9 10.8 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF1772 PF08592.11 CCL98395.1 - 0.56 10.5 4.4 0.7 10.2 3.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DUF2721 PF11026.8 CCL98395.1 - 6.6 6.6 6.6 39 4.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF1192 PF06698.11 CCL98396.1 - 0.011 15.8 0.9 0.035 14.2 0.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Macoilin PF09726.9 CCL98396.1 - 2.7 6.5 8.7 4.4 5.8 2.3 2.9 2 1 0 2 2 2 0 Macoilin family zf-Di19 PF05605.12 CCL98398.1 - 0.00075 19.7 6.7 0.016 15.5 2.6 2.9 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding RNHCP PF12647.7 CCL98398.1 - 0.0061 16.5 0.4 0.0061 16.5 0.4 2.9 3 0 0 3 3 3 1 RNHCP domain E6 PF00518.17 CCL98398.1 - 0.028 14.9 2.9 0.86 10.1 0.2 2.4 1 1 1 2 2 2 0 Early Protein (E6) DUF2197 PF09963.9 CCL98398.1 - 0.37 11.1 5.2 5.2 7.4 0.1 2.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-BED PF02892.15 CCL98398.1 - 5.6 7.1 9.8 3.7 7.6 0.4 3.4 1 1 1 2 2 2 0 BED zinc finger DUF1644 PF07800.12 CCL98398.1 - 7.6 6.6 12.7 0.2 11.7 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) L51_S25_CI-B8 PF05047.16 CCL98400.1 - 3e-12 46.3 0.2 6e-12 45.3 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Romo1 PF10247.9 CCL98402.1 - 1.1e-19 70.6 8.5 1.4e-19 70.2 8.5 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Pex2_Pex12 PF04757.14 CCL98403.1 - 4.4e-23 82.1 5.1 1.2e-22 80.6 5.1 1.6 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 CCL98403.1 - 3.5e-10 39.6 4.2 5.4e-10 39.0 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCL98403.1 - 7.7e-09 35.3 5.8 1.4e-08 34.5 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCL98403.1 - 1.2e-08 35.1 8.4 2.2e-08 34.3 8.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCL98403.1 - 2.1e-08 33.9 6.8 3.6e-08 33.1 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCL98403.1 - 5.5e-08 32.6 4.6 9.4e-08 31.8 4.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCL98403.1 - 4.9e-07 29.7 2.8 6.4e-07 29.3 1.5 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 CCL98403.1 - 3.8e-06 27.1 5.2 8e-06 26.1 5.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CCL98403.1 - 1.2e-05 25.1 6.0 2.1e-05 24.4 6.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain TerY_C PF15616.6 CCL98403.1 - 0.0046 17.1 1.3 0.0078 16.3 1.3 1.3 1 0 0 1 1 1 1 TerY-C metal binding domain zf-RING_10 PF16685.5 CCL98403.1 - 0.0073 16.4 3.9 0.015 15.5 3.9 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 CCL98403.1 - 0.0091 16.1 6.6 0.021 15.0 6.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 CCL98403.1 - 0.02 14.9 1.4 0.036 14.1 1.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCL98403.1 - 0.1 12.4 2.6 0.31 10.8 2.6 1.9 1 0 0 1 1 1 0 RING-like zinc finger IBR PF01485.21 CCL98403.1 - 0.12 12.6 3.7 0.29 11.4 3.7 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_4 PF14570.6 CCL98403.1 - 0.24 11.2 5.8 0.52 10.2 5.8 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain LSM PF01423.22 CCL98404.1 - 1.6e-14 53.3 0.5 2.2e-14 52.9 0.5 1.3 1 1 0 1 1 1 1 LSM domain Hfq PF17209.3 CCL98404.1 - 0.0047 16.5 0.2 0.0084 15.7 0.2 1.5 1 0 0 1 1 1 1 Hfq protein AAA_6 PF12774.7 CCL98405.1 - 5.1e-126 420.1 0.0 7.5e-125 416.2 0.0 2.9 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CCL98405.1 - 4.9e-115 384.8 6.0 4.9e-115 384.8 6.0 3.7 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 CCL98405.1 - 4.4e-75 251.6 0.2 4.4e-75 251.6 0.2 4.8 5 1 1 6 6 6 1 ATP-binding dynein motor region AAA_8 PF12780.7 CCL98405.1 - 6.9e-69 232.1 0.6 7.3e-68 228.7 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 CCL98405.1 - 1.9e-52 178.4 0.0 5.8e-52 176.8 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 CCL98405.1 - 4.8e-43 146.8 0.0 5.6e-37 127.0 0.0 4.9 5 0 0 5 5 4 1 P-loop containing dynein motor region MT PF12777.7 CCL98405.1 - 1.2e-39 136.3 5.1 2e-39 135.6 5.1 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 CCL98405.1 - 1.4e-35 122.5 0.0 2.7e-35 121.6 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CCL98405.1 - 6.9e-30 103.6 0.0 2.6e-28 98.5 0.0 3.3 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 CCL98405.1 - 1.2e-26 93.3 0.0 6.5e-12 45.6 0.0 6.1 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CCL98405.1 - 2.6e-16 59.9 0.0 1.3e-14 54.4 0.0 3.1 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA PF00004.29 CCL98405.1 - 4.7e-13 49.7 0.2 0.00067 20.1 0.0 5.0 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCL98405.1 - 6.5e-12 45.9 0.1 0.0062 16.8 0.0 5.5 4 0 0 4 4 4 2 AAA domain AAA_33 PF13671.6 CCL98405.1 - 4.8e-08 33.3 9.3 0.29 11.3 0.0 6.3 6 0 0 6 6 5 3 AAA domain AAA_16 PF13191.6 CCL98405.1 - 1.1e-07 32.4 0.0 0.61 10.5 0.0 6.4 5 0 0 5 5 5 1 AAA ATPase domain AAA_18 PF13238.6 CCL98405.1 - 1.5e-07 32.1 1.8 0.028 15.0 0.0 5.4 5 0 0 5 5 4 2 AAA domain FtsK_SpoIIIE PF01580.18 CCL98405.1 - 1.2e-06 28.1 0.0 0.31 10.4 0.0 4.3 4 0 0 4 4 4 2 FtsK/SpoIIIE family Mg_chelatase PF01078.21 CCL98405.1 - 1.4e-05 24.5 0.4 0.65 9.3 0.0 3.7 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 CCL98405.1 - 2.2e-05 23.7 0.0 0.022 13.8 0.0 3.5 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_19 PF13245.6 CCL98405.1 - 5e-05 23.7 0.3 0.31 11.4 0.0 4.7 4 0 0 4 4 4 1 AAA domain AAA_lid_1 PF17857.1 CCL98405.1 - 6.6e-05 23.1 1.8 0.00057 20.1 0.0 3.2 3 0 0 3 3 2 1 AAA+ lid domain TrwB_AAD_bind PF10412.9 CCL98405.1 - 0.00028 19.9 0.1 1 8.2 0.0 3.7 3 0 0 3 3 3 1 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.6 CCL98405.1 - 0.00039 20.5 0.1 1.3 9.1 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 CCL98405.1 - 0.00043 20.0 0.1 0.74 9.6 0.0 3.8 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CCL98405.1 - 0.0012 18.6 0.6 26 4.5 0.0 4.6 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 CCL98405.1 - 0.0018 18.8 0.1 12 6.4 0.0 4.6 3 0 0 3 3 3 0 ABC transporter IstB_IS21 PF01695.17 CCL98405.1 - 0.0041 16.9 0.4 0.76 9.5 0.0 4.0 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_24 PF13479.6 CCL98405.1 - 0.016 15.0 1.3 22 4.7 0.0 4.3 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.22 CCL98405.1 - 0.018 15.4 0.5 55 4.2 0.0 4.7 5 0 0 5 5 4 0 RNA helicase AAA_25 PF13481.6 CCL98405.1 - 0.027 14.1 0.0 0.65 9.5 0.0 3.1 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 CCL98405.1 - 0.038 13.9 1.1 24 4.8 0.0 4.9 6 0 0 6 6 6 0 Rad17 P-loop domain TsaE PF02367.17 CCL98405.1 - 0.048 13.7 0.3 14 5.7 0.0 3.8 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_21 PF13304.6 CCL98405.1 - 0.052 13.3 0.0 7.2 6.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system PduV-EutP PF10662.9 CCL98405.1 - 0.091 12.5 0.3 12 5.7 0.0 3.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 CCL98405.1 - 0.1 12.3 0.0 2.2 8.0 0.0 2.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain SRP54 PF00448.22 CCL98405.1 - 0.11 12.1 1.6 40 3.7 0.1 3.8 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain NACHT PF05729.12 CCL98405.1 - 1.4 8.8 6.2 39 4.1 0.1 4.8 6 0 0 6 6 3 0 NACHT domain AAA_11 PF13086.6 CCL98405.1 - 2.4 7.9 14.6 1.4 8.7 0.0 4.1 4 0 0 4 4 4 0 AAA domain HAUS-augmin3 PF14932.6 CCL98405.1 - 7.8 6.0 26.1 2.9 7.4 2.2 3.8 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 3 UPF0242 PF06785.11 CCL98405.1 - 9.2 6.3 21.5 5.2 7.1 3.4 2.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF948 PF06103.11 CCL98405.1 - 9.7 6.5 13.1 20 5.5 0.2 5.7 7 0 0 7 7 3 0 Bacterial protein of unknown function (DUF948) SET PF00856.28 CCL98406.1 - 5.1e-12 46.5 0.0 2.9e-10 40.8 0.0 2.8 2 1 0 2 2 2 1 SET domain dCMP_cyt_deam_1 PF00383.23 CCL98406.1 - 5.7e-07 29.4 0.1 1.8e-06 27.8 0.1 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCL98406.1 - 0.00013 21.8 0.1 0.00025 20.8 0.1 1.4 1 0 0 1 1 1 1 MafB19-like deaminase TilS PF09179.11 CCL98406.1 - 0.0069 16.8 0.1 0.023 15.2 0.1 1.9 1 0 0 1 1 1 1 TilS substrate binding domain F-box-like PF12937.7 CCL98407.1 - 1.8e-09 37.3 1.7 1.8e-09 37.3 1.7 2.5 2 0 0 2 2 2 1 F-box-like PLDc_2 PF13091.6 CCL98408.1 - 3.1e-07 30.3 0.0 6.5e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.22 CCL98408.1 - 3.2e-05 23.9 0.1 6.7e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Phospholipase D Active site motif PX PF00787.24 CCL98409.1 - 1.9e-10 40.7 0.6 5.3e-10 39.3 0.1 2.1 2 0 0 2 2 2 1 PX domain PLDc PF00614.22 CCL98409.1 - 7.5e-06 25.9 0.1 1.5e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 Phospholipase D Active site motif PLDc_2 PF13091.6 CCL98409.1 - 0.00035 20.5 0.0 0.0007 19.5 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain DUF4630 PF15443.6 CCL98410.1 - 0.034 14.3 0.7 0.54 10.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4630) Herpes_BLRF2 PF05812.12 CCL98410.1 - 0.04 14.1 0.1 0.65 10.1 0.0 2.3 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein HTH_Tnp_1 PF01527.20 CCL98410.1 - 0.087 13.2 2.5 0.22 11.8 2.5 1.7 1 0 0 1 1 1 0 Transposase NYD-SP28_assoc PF14775.6 CCL98410.1 - 0.26 11.4 3.0 0.23 11.6 1.3 1.7 2 0 0 2 2 2 0 Sperm tail C-terminal domain SIKE PF05769.11 CCL98410.1 - 0.27 11.1 4.2 0.1 12.5 1.1 1.8 2 0 0 2 2 2 0 SIKE family SPC12 PF06645.13 CCL98411.1 - 4.3e-26 90.8 0.5 6.7e-26 90.2 0.5 1.3 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) UbiA PF01040.18 CCL98411.1 - 0.0095 15.3 0.6 0.012 14.9 0.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Erv26 PF04148.13 CCL98411.1 - 0.079 12.8 0.1 0.085 12.7 0.1 1.1 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 DUF2207 PF09972.9 CCL98411.1 - 0.14 10.9 0.1 0.15 10.8 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ost4 PF10215.9 CCL98411.1 - 0.14 12.0 1.2 0.28 11.1 1.2 1.5 1 0 0 1 1 1 0 Oligosaccaryltransferase SAP PF02037.27 CCL98412.1 - 0.0041 16.8 0.7 0.021 14.5 0.7 2.2 1 1 0 1 1 1 1 SAP domain Rho_N PF07498.12 CCL98412.1 - 0.0092 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain F-actin_cap_A PF01267.17 CCL98413.1 - 1.9e-89 299.6 0.0 5.9e-89 298.0 0.0 1.6 1 1 0 1 1 1 1 F-actin capping protein alpha subunit SMC_N PF02463.19 CCL98415.1 - 2.7e-28 98.9 0.0 1.3e-27 96.7 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCL98415.1 - 3.1e-19 70.3 1.0 3.1e-19 70.3 1.0 5.4 3 2 1 4 4 2 1 AAA domain AAA_21 PF13304.6 CCL98415.1 - 6.8e-07 29.4 1.6 0.0012 18.8 0.1 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CCL98415.1 - 3.8e-06 26.8 17.3 3.8e-06 26.8 17.3 4.1 3 2 1 4 4 3 1 AAA ATPase domain AAA_29 PF13555.6 CCL98415.1 - 0.0004 20.1 0.2 0.0018 18.0 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain CRR7 PF12095.8 CCL98415.1 - 0.067 13.6 0.1 0.067 13.6 0.1 4.9 4 3 1 6 6 5 0 Protein CHLORORESPIRATORY REDUCTION 7 SbcCD_C PF13558.6 CCL98415.1 - 0.073 13.3 0.0 0.24 11.7 0.0 1.8 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 CCL98415.1 - 0.16 12.4 0.1 0.16 12.4 0.1 5.0 3 2 0 3 3 3 0 ABC transporter Baculo_PEP_C PF04513.12 CCL98415.1 - 0.19 11.8 28.9 0.014 15.4 2.4 5.4 5 1 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.11 CCL98415.1 - 1.5 6.7 35.2 0.036 12.0 15.5 2.7 2 2 0 2 2 2 0 Prominin HsbA PF12296.8 CCL98415.1 - 4.2 7.8 9.2 20 5.6 4.6 3.9 2 2 0 3 3 3 0 Hydrophobic surface binding protein A TFIIA PF03153.13 CCL98416.1 - 5.4 6.9 13.7 7.8 6.4 13.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glycos_transf_4 PF00953.21 CCL98417.1 - 9.3e-32 110.2 5.9 9.3e-32 110.2 5.9 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 4 ICL PF00463.21 CCL98418.1 - 2.2e-256 851.5 0.1 2.4e-256 851.3 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 CCL98418.1 - 8.4e-08 32.0 0.0 1.7e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase TraB PF01963.17 CCL98418.1 - 0.1 12.5 0.0 8.2 6.2 0.0 2.2 2 0 0 2 2 2 0 TraB family MFS_1 PF07690.16 CCL98419.1 - 2.9e-27 95.5 56.9 2.9e-21 75.8 33.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TPPK_C PF12555.8 CCL98419.1 - 0.039 14.0 1.1 1.4 9.0 0.1 2.9 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal F-box-like PF12937.7 CCL98421.1 - 0.0044 16.9 1.7 0.0044 16.9 1.7 2.4 2 0 0 2 2 2 1 F-box-like Ribosomal_L24e PF01246.20 CCL98422.1 - 6.6e-27 93.5 1.7 9.6e-27 93.0 0.4 2.1 2 0 0 2 2 2 1 Ribosomal protein L24e UvrD_C PF13361.6 CCL98422.1 - 1.6e-08 34.3 0.0 1.2e-05 24.9 0.0 2.7 2 1 1 3 3 3 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 CCL98422.1 - 3.2e-07 30.1 0.0 0.012 15.5 0.0 2.6 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 CCL98422.1 - 2e-06 27.6 2.1 0.00029 20.5 0.0 3.2 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CCL98422.1 - 4.8e-05 23.7 0.0 0.0004 20.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCL98422.1 - 0.0039 17.5 0.0 0.25 11.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 CCL98422.1 - 0.0099 15.5 0.0 0.026 14.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCL98422.1 - 0.025 14.9 0.0 0.16 12.3 0.0 2.4 1 0 0 1 1 1 0 AAA ATPase domain TERB2 PF15101.6 CCL98422.1 - 0.57 10.2 2.7 11 6.0 1.4 2.4 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Presenilin PF01080.17 CCL98422.1 - 0.61 8.8 2.3 0.97 8.1 2.3 1.2 1 0 0 1 1 1 0 Presenilin TPR_1 PF00515.28 CCL98422.1 - 1.7 8.6 8.1 20 5.2 0.2 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCL98422.1 - 2.6 8.4 9.0 23 5.4 0.1 5.1 4 1 1 5 5 4 0 Tetratricopeptide repeat zf_ZIC PF18366.1 CCL98423.1 - 1.5 9.0 7.8 0.8 9.9 2.3 2.6 3 0 0 3 3 3 0 Zic proteins zinc finger domain Lzipper-MIP1 PF14389.6 CCL98424.1 - 0.27 11.6 1.3 0.5 10.7 0.3 2.0 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Glyco_hydro_18 PF00704.28 CCL98427.1 - 2.5e-69 234.4 4.7 2.5e-69 234.4 4.7 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 CBM_5_12 PF02839.14 CCL98427.1 - 0.014 15.9 6.3 0.014 15.9 6.3 3.0 2 1 0 2 2 2 0 Carbohydrate binding domain Sporozoite_P67 PF05642.11 CCL98427.1 - 3.7 5.5 19.7 11 3.9 19.0 1.8 1 1 1 2 2 2 0 Sporozoite P67 surface antigen MGC-24 PF05283.11 CCL98427.1 - 7.5 7.0 20.4 17 5.8 20.4 1.7 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin F-box-like PF12937.7 CCL98428.1 - 0.00089 19.1 0.6 0.092 12.7 0.1 2.9 3 0 0 3 3 3 2 F-box-like DUF2310 PF10071.9 CCL98428.1 - 0.092 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) Abhydrolase_1 PF00561.20 CCL98429.1 - 1.2e-13 51.3 0.0 2.4e-13 50.3 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL98429.1 - 1.8e-12 48.3 0.7 2.6e-12 47.8 0.7 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL98429.1 - 9.7e-08 31.6 0.0 1.1e-06 28.1 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CCL98429.1 - 0.00028 21.1 0.0 0.00038 20.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain DUF1772 PF08592.11 CCL98430.1 - 1.1 9.6 5.4 2.2 8.6 4.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) CENP-N PF05238.13 CCL98431.1 - 0.04 13.2 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like SUR7 PF06687.12 CCL98432.1 - 8.7e-18 64.7 10.2 1.1e-17 64.4 10.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family Meckelin PF09773.9 CCL98432.1 - 0.3 9.1 1.2 0.43 8.6 1.2 1.1 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) Tetraspanin PF00335.20 CCL98432.1 - 3.3 7.3 8.8 1 9.0 0.6 2.6 2 1 1 3 3 3 0 Tetraspanin family Methyltr_RsmB-F PF01189.17 CCL98433.1 - 1.1e-76 257.0 0.0 1.6e-76 256.4 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 CCL98433.1 - 2.1e-08 34.5 0.0 1.2e-07 32.1 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF PCMT PF01135.19 CCL98433.1 - 0.002 17.9 0.0 0.0032 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CCL98433.1 - 0.008 16.0 0.0 0.027 14.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF3827 PF12877.7 CCL98433.1 - 0.026 12.9 0.7 0.051 12.0 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF938 PF06080.12 CCL98433.1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_25 PF13649.6 CCL98433.1 - 0.078 13.7 0.0 0.23 12.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 CCL98433.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase FUN14 PF04930.15 CCL98434.1 - 9.9e-20 70.8 1.3 1.4e-19 70.3 1.3 1.2 1 0 0 1 1 1 1 FUN14 family Coprogen_oxidas PF01218.18 CCL98435.1 - 2.9e-103 344.6 0.0 3.4e-103 344.4 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Ion_trans PF00520.31 CCL98437.1 - 2.1e-06 27.2 2.4 2.8e-06 26.8 2.4 1.1 1 0 0 1 1 1 1 Ion transport protein BMFP PF04380.13 CCL98437.1 - 0.022 15.2 1.9 0.039 14.4 1.9 1.4 1 0 0 1 1 1 0 Membrane fusogenic activity Uso1_p115_C PF04871.13 CCL98437.1 - 0.026 14.9 0.8 0.045 14.1 0.8 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF485 PF04341.12 CCL98438.1 - 5.3 7.1 8.3 0.52 10.3 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 COesterase PF00135.28 CCL98439.1 - 6.3e-76 256.3 0.0 9.2e-76 255.7 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCL98439.1 - 7.2e-09 35.8 1.6 7.2e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCL98439.1 - 0.0026 17.3 0.6 0.0085 15.6 0.1 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family MFS_1 PF07690.16 CCL98441.1 - 3e-12 46.1 25.8 3.6e-12 45.9 25.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ALG3 PF05208.13 CCL98442.1 - 1.1e-134 449.5 12.1 1.3e-134 449.2 12.1 1.0 1 0 0 1 1 1 1 ALG3 protein DUF2198 PF09964.9 CCL98442.1 - 4.6 7.4 10.1 0.82 9.8 1.1 3.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2198) Cellulase PF00150.18 CCL98443.1 - 1.1e-13 51.2 0.0 3.3e-13 49.7 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ist1 PF03398.14 CCL98444.1 - 5e-32 111.1 1.2 7.4e-32 110.5 1.2 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway RabGAP-TBC PF00566.18 CCL98444.1 - 8.3e-13 48.5 0.1 1.3e-09 38.0 0.0 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF1772 PF08592.11 CCL98445.1 - 0.89 9.9 6.8 1.6 9.0 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) HEAT PF02985.22 CCL98446.1 - 3.7e-17 60.9 17.5 0.012 15.8 0.0 9.1 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.6 CCL98446.1 - 1.4e-12 47.9 13.9 0.00016 22.0 0.1 6.6 4 2 2 6 6 6 5 HEAT repeats HEAT_EZ PF13513.6 CCL98446.1 - 2.1e-05 24.9 10.2 0.046 14.2 0.1 5.1 5 0 0 5 5 5 2 HEAT-like repeat Cnd1 PF12717.7 CCL98446.1 - 0.0001 22.4 0.2 0.54 10.3 0.0 3.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 CCL98446.1 - 0.0013 19.2 0.2 2.8 8.9 0.1 4.1 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat Adaptin_N PF01602.20 CCL98446.1 - 0.17 10.4 0.2 0.88 8.0 0.0 2.1 2 1 0 2 2 2 0 Adaptin N terminal region GST_N_3 PF13417.6 CCL98447.1 - 3.4e-11 43.4 0.1 7.6e-11 42.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCL98447.1 - 7.9e-07 29.3 0.1 3.4e-06 27.3 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCL98447.1 - 6.7e-05 22.8 0.4 0.00014 21.8 0.4 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCL98447.1 - 0.063 13.6 0.0 0.18 12.1 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCL98447.1 - 0.13 12.4 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain tRNA-synt_1 PF00133.22 CCL98448.1 - 4.2e-211 702.4 0.0 4.2e-210 699.0 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCL98448.1 - 1.7e-36 125.5 0.1 4.1e-36 124.2 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCL98448.1 - 1.5e-14 53.6 0.0 7.7e-07 28.2 0.0 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CCL98448.1 - 9.7e-11 41.5 2.8 2.2e-07 30.6 0.1 2.7 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 DUF3275 PF11679.8 CCL98448.1 - 0.037 14.0 0.2 0.078 13.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) tRNA-synt_1e PF01406.19 CCL98448.1 - 0.11 11.9 0.0 0.9 8.8 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Nse4_C PF08743.10 CCL98449.1 - 3.7e-32 110.4 0.3 1.4e-31 108.6 0.0 2.1 2 0 0 2 2 2 1 Nse4 C-terminal ASXH PF13919.6 CCL98449.1 - 3.1e-21 75.8 3.4 3.1e-21 75.8 3.4 2.1 2 1 0 2 2 2 1 Asx homology domain Nse4-Nse3_bdg PF15412.6 CCL98449.1 - 1.8e-15 56.7 0.5 5.6e-15 55.2 0.5 1.9 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Chloroplast_duf PF14476.6 CCL98449.1 - 0.061 12.3 0.0 0.098 11.6 0.0 1.2 1 0 0 1 1 1 0 Petal formation-expressed GST_C_2 PF13410.6 CCL98450.1 - 0.00019 21.4 0.1 0.00042 20.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCL98450.1 - 0.00055 20.1 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCL98450.1 - 0.0098 16.3 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF5018 PF16410.5 CCL98450.1 - 0.23 10.1 0.0 0.33 9.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) F-box PF00646.33 CCL98451.1 - 4.8e-05 23.1 0.1 0.00012 21.9 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCL98451.1 - 0.0001 22.1 1.1 0.00022 21.1 1.1 1.6 1 0 0 1 1 1 1 F-box-like Redoxin PF08534.10 CCL98453.1 - 8.2e-25 87.2 0.0 9.7e-25 87.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CCL98453.1 - 6.2e-11 42.3 0.0 7.5e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CCL98453.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like MRG PF05712.13 CCL98454.1 - 1.8e-56 190.6 0.2 2.8e-56 190.0 0.2 1.2 1 0 0 1 1 1 1 MRG Pkinase PF00069.25 CCL98454.1 - 1.6e-21 76.9 0.0 3.2e-21 75.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 CCL98454.1 - 9.6e-10 37.8 0.2 1.6e-09 37.1 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 CCL98454.1 - 1.7e-09 37.4 0.0 2.8e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Tudor-knot PF11717.8 CCL98454.1 - 1e-08 34.9 0.5 1.8e-08 34.2 0.5 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain APH PF01636.23 CCL98454.1 - 0.071 13.0 0.2 0.19 11.6 0.1 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Hce2 PF14856.6 CCL98455.1 - 0.0077 16.5 0.1 0.015 15.6 0.1 1.5 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor NifU_N PF01592.16 CCL98455.1 - 0.056 13.6 0.1 0.087 12.9 0.1 1.3 1 0 0 1 1 1 0 NifU-like N terminal domain Mago_nashi PF02792.14 CCL98456.1 - 1.9e-75 251.7 0.4 2.1e-75 251.6 0.4 1.0 1 0 0 1 1 1 1 Mago nashi protein Ribosomal_S10 PF00338.22 CCL98457.1 - 2.7e-27 94.8 0.0 5.7e-27 93.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF4451 PF14616.6 CCL98458.1 - 5.2e-15 55.7 11.2 1.4e-07 31.7 0.1 3.2 2 2 1 3 3 3 2 Domain of unknown function (DUF4451) EMP24_GP25L PF01105.24 CCL98459.1 - 4.2e-26 92.0 0.0 4.9e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Aldedh PF00171.22 CCL98460.1 - 2.2e-115 385.8 0.0 2.5e-115 385.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCL98460.1 - 0.00024 20.3 0.0 0.00036 19.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) BAR_2 PF10455.9 CCL98461.1 - 9.9e-52 175.9 0.3 7.1e-29 100.8 0.0 2.0 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 CCL98461.1 - 1.3e-17 64.2 2.7 2.2e-16 60.2 2.7 2.0 1 1 0 1 1 1 1 BAR domain LigT_PEase PF02834.16 CCL98461.1 - 0.12 12.6 0.0 0.41 10.9 0.0 2.0 1 0 0 1 1 1 0 LigT like Phosphoesterase ZapB PF06005.12 CCL98461.1 - 4.6 7.7 6.9 1.2 9.7 0.2 3.2 3 1 0 3 3 3 0 Cell division protein ZapB Proteasome PF00227.26 CCL98462.1 - 2.7e-48 164.0 0.0 3.3e-48 163.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 CCL98462.1 - 1.2e-12 47.0 0.2 1.2e-12 47.0 0.2 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal NAD_Gly3P_dh_C PF07479.14 CCL98462.1 - 0.033 14.5 0.0 0.072 13.4 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus SpoIIE PF07228.12 CCL98463.1 - 0.0038 17.2 0.0 0.02 14.8 0.0 2.0 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CCL98463.1 - 0.021 14.4 0.8 1.2 8.7 0.2 2.3 2 0 0 2 2 2 0 Protein phosphatase 2C MFS_1 PF07690.16 CCL98464.1 - 2e-19 69.7 61.8 6.6e-17 61.5 41.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily F-box-like PF12937.7 CCL98465.1 - 0.0059 16.5 1.3 0.0059 16.5 1.3 2.2 3 0 0 3 3 3 1 F-box-like Transposase_mut PF00872.18 CCL98465.1 - 0.11 11.3 0.1 0.18 10.6 0.1 1.2 1 0 0 1 1 1 0 Transposase, Mutator family AAA PF00004.29 CCL98466.1 - 1.4e-55 187.4 0.0 1.6e-43 148.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 CCL98466.1 - 2.8e-24 85.3 0.4 7.1e-24 84.0 0.4 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 CCL98466.1 - 1e-16 60.4 0.2 4.9e-10 39.1 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CCL98466.1 - 2.4e-11 44.3 3.1 0.00065 20.1 0.1 4.7 2 2 2 4 4 4 2 AAA ATPase domain RuvB_N PF05496.12 CCL98466.1 - 1.8e-06 27.8 0.0 0.0054 16.5 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CCL98466.1 - 1e-05 25.6 0.0 0.11 12.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCL98466.1 - 1.3e-05 25.5 1.5 1 9.6 0.1 4.3 2 2 2 4 4 4 2 AAA domain AAA_2 PF07724.14 CCL98466.1 - 4.7e-05 23.6 0.0 0.042 14.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 CCL98466.1 - 0.00016 21.7 0.0 0.15 12.0 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 CCL98466.1 - 0.00016 22.2 0.0 0.19 12.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 CCL98466.1 - 0.00018 21.5 0.0 0.86 9.6 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 CCL98466.1 - 0.00027 20.9 0.0 0.018 14.9 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein RNA_helicase PF00910.22 CCL98466.1 - 0.00033 21.0 0.0 1.1 9.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 CCL98466.1 - 0.00038 20.4 0.3 0.81 9.6 0.0 3.5 3 1 0 3 3 3 1 NACHT domain AAA_33 PF13671.6 CCL98466.1 - 0.0004 20.6 0.0 0.04 14.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 CCL98466.1 - 0.00045 20.7 0.0 0.12 12.9 0.0 2.8 2 0 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.12 CCL98466.1 - 0.00046 19.5 0.1 0.83 8.9 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_5 PF07728.14 CCL98466.1 - 0.0011 18.9 0.0 0.66 10.0 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCL98466.1 - 0.0017 18.1 0.1 0.63 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CCL98466.1 - 0.0031 16.8 0.0 0.11 11.7 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_25 PF13481.6 CCL98466.1 - 0.0044 16.6 0.5 0.87 9.1 0.1 3.7 3 1 1 4 4 4 1 AAA domain Viral_helicase1 PF01443.18 CCL98466.1 - 0.011 15.5 0.0 0.35 10.6 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 CCL98466.1 - 0.012 14.8 0.0 3.6 6.7 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 CCL98466.1 - 0.015 15.2 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 CCL98466.1 - 0.016 15.6 0.1 0.32 11.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCL98466.1 - 0.019 14.7 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 CCL98466.1 - 0.02 14.6 0.0 3.3 7.4 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 CCL98466.1 - 0.023 14.4 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 CCL98466.1 - 0.027 14.8 0.0 0.62 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 CCL98466.1 - 0.036 13.3 0.2 0.12 11.6 0.0 1.9 2 1 0 2 2 1 0 KAP family P-loop domain DUF2075 PF09848.9 CCL98466.1 - 0.037 13.3 1.9 4.6 6.4 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 CCL98466.1 - 0.056 12.5 0.0 0.98 8.4 0.0 2.5 3 0 0 3 3 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 CCL98466.1 - 0.057 12.9 0.0 9.2 5.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 CCL98466.1 - 0.065 13.3 0.2 2.7 8.1 0.0 3.1 3 0 0 3 3 3 0 50S ribosome-binding GTPase Mg_chelatase PF01078.21 CCL98466.1 - 0.073 12.4 0.2 0.73 9.2 0.0 2.4 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCL98466.1 - 0.082 12.8 0.0 0.8 9.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CCL98466.1 - 0.095 12.6 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 CCL98466.1 - 0.11 12.1 0.1 1.7 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 CCL98466.1 - 0.16 11.7 0.1 0.5 10.1 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family cobW PF02492.19 CCL98466.1 - 0.21 11.2 0.3 3.8 7.1 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sacchrp_dh_C PF16653.5 CCL98467.1 - 5.2e-76 256.2 0.0 8.6e-76 255.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 CCL98467.1 - 5.4e-19 68.7 0.2 4e-18 65.9 0.0 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_N PF05222.15 CCL98467.1 - 9e-10 39.0 0.0 1.1e-08 35.5 0.0 2.6 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 CCL98467.1 - 3.2e-07 29.9 0.0 0.0008 18.8 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Stanniocalcin PF03298.13 CCL98467.1 - 0.015 14.6 0.1 0.043 13.1 0.0 1.7 2 0 0 2 2 2 0 Stanniocalcin family Shikimate_DH PF01488.20 CCL98467.1 - 0.025 14.6 0.0 0.05 13.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Mid1 PF12929.7 CCL98468.1 - 1.9e-56 192.1 0.0 2.4e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 CCL98468.1 - 0.0018 18.9 3.2 0.049 14.3 0.5 2.5 2 0 0 2 2 2 2 Fz domain DnaJ PF00226.31 CCL98469.1 - 2.2e-19 69.3 0.0 4.8e-19 68.3 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 CCL98469.1 - 9e-16 56.7 2.1 1 9.7 0.0 8.9 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_9 PF13371.6 CCL98469.1 - 4.7e-13 49.1 10.8 0.0083 16.3 0.1 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 CCL98469.1 - 9.9e-11 41.0 0.1 0.082 12.8 0.0 7.8 10 0 0 10 10 10 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCL98469.1 - 1.5e-10 41.0 0.1 0.85 9.7 0.1 5.3 5 0 0 5 5 5 4 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 CCL98469.1 - 1.7e-08 34.8 6.2 0.24 11.9 0.3 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCL98469.1 - 2.1e-08 34.7 7.1 0.00091 19.8 0.2 6.2 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCL98469.1 - 2.8e-05 23.7 5.0 1.6 8.5 0.0 6.8 8 0 0 8 8 8 1 TPR repeat TPR_8 PF13181.6 CCL98469.1 - 0.00014 21.8 0.0 11 6.5 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCL98469.1 - 0.00095 19.8 13.5 0.26 12.2 0.3 6.9 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCL98469.1 - 0.017 15.7 4.0 24 5.8 0.1 5.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_15 PF13429.6 CCL98469.1 - 0.036 13.3 2.8 0.094 11.9 0.5 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat FAD_binding_3 PF01494.19 CCL98471.1 - 7.8e-19 68.1 0.0 1.1e-10 41.3 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CCL98471.1 - 1.3e-05 25.3 0.0 0.001 19.2 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 CCL98471.1 - 0.012 14.4 0.1 0.06 12.2 0.0 1.8 1 1 0 2 2 2 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 CCL98471.1 - 0.09 12.0 0.0 1.1 8.4 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UCR_Fe-S_N PF10399.9 CCL98471.1 - 0.11 11.9 0.1 0.29 10.5 0.1 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal FAD_binding_3 PF01494.19 CCL98472.1 - 1.6e-24 86.8 0.0 2.2e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 CCL98472.1 - 9.4e-06 24.7 0.0 1.7e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Tryptophan halogenase NAD_binding_8 PF13450.6 CCL98472.1 - 0.00096 19.3 0.4 0.002 18.3 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCL98472.1 - 0.0032 16.7 0.0 0.013 14.8 0.0 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCL98472.1 - 0.0033 17.4 0.1 0.034 14.1 0.2 2.6 4 0 0 4 4 4 1 FAD-NAD(P)-binding SE PF08491.10 CCL98472.1 - 0.022 13.8 0.1 0.23 10.4 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase DAO PF01266.24 CCL98472.1 - 0.025 14.2 0.7 0.043 13.4 0.7 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase TetR_C_11 PF16859.5 CCL98472.1 - 0.048 14.0 0.1 0.25 11.7 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MFS_1 PF07690.16 CCL98473.1 - 8.6e-12 44.6 35.0 8.6e-12 44.6 35.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3341 PF11821.8 CCL98473.1 - 0.22 11.1 1.2 17 5.0 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3341) DUF2070 PF09843.9 CCL98473.1 - 7 4.8 10.7 0.1 10.9 2.6 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Cerato-platanin PF07249.12 CCL98474.1 - 5e-48 162.1 2.9 6.2e-48 161.8 2.9 1.1 1 0 0 1 1 1 1 Cerato-platanin DUF21 PF01595.20 CCL98475.1 - 1.8e-33 115.7 0.3 2.9e-33 115.1 0.3 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain p450 PF00067.22 CCL98477.1 - 7.4e-74 249.1 0.0 1.5e-73 248.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Peptidase_C12 PF01088.21 CCL98478.1 - 9.4e-52 175.8 0.0 1.5e-51 175.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 CCL98478.1 - 9.3e-10 38.3 0.0 2.7e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Cep57_CLD_2 PF14197.6 CCL98478.1 - 0.014 15.5 1.0 0.064 13.3 0.7 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 RPA_interact_M PF14767.6 CCL98478.1 - 0.23 12.1 1.9 2.1 9.0 0.8 3.0 2 1 0 2 2 2 0 Replication protein A interacting middle Abhydrolase_1 PF00561.20 CCL98479.1 - 3.3e-20 72.8 0.0 2.6e-19 69.9 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL98479.1 - 1.5e-11 45.3 0.0 1.8e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL98479.1 - 2.1e-08 33.7 0.0 1.9e-06 27.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 CCL98479.1 - 0.00077 19.1 0.1 0.0025 17.4 0.0 1.8 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Thioesterase PF00975.20 CCL98479.1 - 0.0049 17.0 0.0 0.0079 16.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 CCL98479.1 - 0.0062 16.2 0.0 0.0087 15.7 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 CCL98479.1 - 0.074 12.8 0.0 0.17 11.7 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase RP-C_C PF11800.8 CCL98480.1 - 3.1 7.8 8.3 0.14 12.3 0.5 2.2 2 0 0 2 2 2 0 Replication protein C C-terminal region Clat_adaptor_s PF01217.20 CCL98481.1 - 2.9e-17 62.9 0.0 5e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AP-5_subunit_s1 PF15001.6 CCL98481.1 - 0.065 13.2 0.1 0.12 12.3 0.1 1.5 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 Abhydrolase_1 PF00561.20 CCL98482.1 - 7.6e-21 74.9 0.0 1e-20 74.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCL98482.1 - 2.2e-08 33.7 0.0 3.1e-07 29.9 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCL98482.1 - 2.5e-05 25.0 0.0 3.3e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CCL98482.1 - 0.0025 17.5 0.0 0.0041 16.7 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 CCL98483.1 - 2e-11 44.9 0.8 2e-11 44.9 0.8 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL98483.1 - 0.00018 20.9 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCL98483.1 - 0.0095 15.6 0.0 0.019 14.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold YniB PF14002.6 CCL98484.1 - 0.28 11.0 0.1 4.7 7.0 0.0 2.1 2 0 0 2 2 2 0 YniB-like protein Abhydrolase_1 PF00561.20 CCL98485.1 - 9.7e-17 61.5 0.0 1.5e-16 60.8 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL98485.1 - 3.8e-08 34.2 0.0 4.5e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL98485.1 - 9.9e-08 31.5 0.0 1.4e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 CCL98485.1 - 0.0013 18.4 0.0 0.0046 16.6 0.0 1.8 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 CCL98485.1 - 0.0097 15.7 0.0 0.048 13.5 0.0 1.9 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase SPX PF03105.19 CCL98486.1 - 1.9e-27 97.2 0.0 9.5e-27 94.9 0.0 2.1 1 1 0 1 1 1 1 SPX domain zf-C3HC4_3 PF13920.6 CCL98486.1 - 3.7e-07 29.9 8.6 6.4e-07 29.1 8.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCL98486.1 - 6.6e-07 29.1 10.8 1.2e-06 28.3 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCL98486.1 - 3.5e-06 27.1 9.2 6.6e-06 26.2 9.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CCL98486.1 - 7.2e-06 26.2 10.2 1.4e-05 25.4 10.2 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 CCL98486.1 - 2.2e-05 24.2 9.2 4.4e-05 23.3 9.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCL98486.1 - 0.00036 20.4 9.4 0.00075 19.4 9.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCL98486.1 - 0.00038 20.2 11.2 0.00065 19.5 11.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCL98486.1 - 0.0012 18.9 8.3 0.0024 17.9 8.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 CCL98486.1 - 0.0015 18.3 2.8 0.0032 17.2 2.8 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 CCL98486.1 - 0.003 17.6 4.6 0.0064 16.6 4.6 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 CCL98486.1 - 0.027 14.8 7.2 0.065 13.5 7.2 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCL98486.1 - 0.12 12.5 2.3 0.21 11.6 2.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 CCL98486.1 - 0.49 10.3 3.5 1 9.3 3.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Cellulase PF00150.18 CCL98487.1 - 2.4e-29 102.6 0.9 3.7e-29 102.1 0.9 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cellulase PF00150.18 CCL98488.1 - 1.7e-31 109.7 0.4 2.8e-31 109.0 0.4 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Peptidase_M24 PF00557.24 CCL98489.1 - 2e-55 187.7 0.0 3.5e-55 186.9 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 RNase_PH PF01138.21 CCL98489.1 - 9.8e-17 61.7 0.0 1.9e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 AMP_N PF05195.16 CCL98489.1 - 0.047 13.4 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 Aminopeptidase P, N-terminal domain SNF5 PF04855.12 CCL98490.1 - 7.2e-75 251.8 0.0 4.6e-74 249.2 0.0 1.9 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 CBFD_NFYB_HMF PF00808.23 CCL98491.1 - 3e-16 59.5 1.2 5.7e-16 58.5 1.2 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SLD5_C PF16922.5 CCL98491.1 - 1.9e-08 34.3 0.6 6.6e-08 32.6 0.0 2.3 2 0 0 2 2 2 1 DNA replication complex GINS protein SLD5 C-terminus Histone PF00125.24 CCL98491.1 - 7e-06 26.4 0.4 7e-06 26.4 0.4 2.6 3 0 0 3 3 2 1 Core histone H2A/H2B/H3/H4 BUD22 PF09073.10 CCL98491.1 - 3.8e-05 23.2 15.4 5.8e-05 22.6 15.4 1.3 1 0 0 1 1 1 1 BUD22 Sld5 PF05916.11 CCL98491.1 - 0.00029 21.2 0.1 0.00065 20.1 0.1 1.6 1 0 0 1 1 1 1 GINS complex protein CNDH2_C PF16858.5 CCL98491.1 - 0.018 14.9 7.5 0.032 14.1 7.5 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term MDM1 PF15501.6 CCL98491.1 - 0.022 13.9 13.9 0.033 13.3 13.9 1.2 1 0 0 1 1 1 0 Nuclear protein MDM1 TAFII28 PF04719.14 CCL98491.1 - 0.033 14.3 1.1 0.084 13.0 1.1 1.6 1 0 0 1 1 1 0 hTAFII28-like protein conserved region CK2S PF15011.6 CCL98491.1 - 0.073 13.0 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Casein Kinase 2 substrate A_deaminase_N PF08451.11 CCL98491.1 - 0.63 10.4 4.2 1.4 9.2 4.2 1.5 1 0 0 1 1 1 0 Adenosine/AMP deaminase N-terminal MAJIN PF15077.6 CCL98491.1 - 0.72 9.6 5.4 1.2 8.8 5.4 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein RR_TM4-6 PF06459.12 CCL98491.1 - 2 8.2 8.2 3.4 7.4 8.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sulfate_transp PF00916.20 CCL98492.1 - 4.5e-60 203.4 22.6 4.5e-60 203.4 22.6 1.6 2 0 0 2 2 2 1 Sulfate permease family cNMP_binding PF00027.29 CCL98492.1 - 3.1e-11 43.2 0.0 8.8e-11 41.7 0.0 1.8 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain STAS PF01740.21 CCL98492.1 - 1.3e-09 37.7 0.1 2.8e-09 36.6 0.1 1.5 1 0 0 1 1 1 1 STAS domain UCR_UQCRX_QCR9 PF05365.12 CCL98492.1 - 0.093 12.7 0.0 0.29 11.1 0.0 1.9 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like MFS_MOT1 PF16983.5 CCL98492.1 - 1 9.8 24.9 0.02 15.3 4.3 3.9 3 1 0 3 3 3 0 Molybdate transporter of MFS superfamily rRNA_proc-arch PF13234.6 CCL98493.1 - 1.1e-86 291.2 0.0 2.2e-86 290.1 0.0 1.6 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 CCL98493.1 - 1e-53 181.4 0.5 2.2e-53 180.3 0.5 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 CCL98493.1 - 5.7e-12 45.8 0.1 3.2e-10 40.0 0.1 2.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCL98493.1 - 2.1e-07 31.3 0.0 9.5e-07 29.1 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain T2SSE PF00437.20 CCL98493.1 - 0.054 12.5 0.0 0.16 11.0 0.0 1.8 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 CCL98493.1 - 0.064 13.3 0.0 9 6.3 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Com_YlbF PF06133.11 CCL98493.1 - 0.24 12.0 6.5 0.92 10.2 0.1 3.8 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA Cyt-b5 PF00173.28 CCL98494.1 - 4.7e-12 45.9 0.0 5.9e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain p450 PF00067.22 CCL98495.1 - 2.2e-64 217.9 0.0 1.1e-63 215.6 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 Abhydrolase_3 PF07859.13 CCL98496.1 - 9e-14 51.8 0.0 3.8e-13 49.8 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCL98496.1 - 4.3e-07 29.2 0.0 6.1e-05 22.1 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Peptidase_S9 PF00326.21 CCL98496.1 - 0.00016 21.2 0.0 0.25 10.8 0.0 2.7 2 1 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CCL98496.1 - 0.00062 19.1 0.0 0.0013 18.1 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 CCL98496.1 - 0.00097 18.1 0.0 0.0014 17.6 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 CCL98496.1 - 0.0023 16.9 0.0 0.0037 16.2 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 CCL98496.1 - 0.0054 17.4 0.0 0.0097 16.5 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase PF07224.11 CCL98496.1 - 0.072 12.1 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase PGAP1 PF07819.13 CCL98496.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein HET PF06985.11 CCL98497.1 - 1.1e-10 42.0 3.7 1e-08 35.6 0.2 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Neuro_bHLH PF12533.8 CCL98497.1 - 0.62 11.2 3.0 0.41 11.8 0.3 2.0 2 0 0 2 2 2 0 Neuronal helix-loop-helix transcription factor F-box PF00646.33 CCL98498.1 - 1.2e-09 37.8 0.5 2.6e-09 36.7 0.2 1.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CCL98498.1 - 2.8e-07 30.3 0.6 2.8e-07 30.3 0.6 2.1 2 0 0 2 2 2 1 F-box-like RhoGEF PF00621.20 CCL98499.1 - 2.6e-17 63.6 0.0 4.7e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain NUDIX_2 PF13869.6 CCL98500.1 - 1.9e-84 282.0 0.0 2.1e-84 281.8 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase Glyco_hydro_61 PF03443.14 CCL98501.1 - 6.7e-56 189.5 0.0 8.9e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Zip PF02535.22 CCL98502.1 - 1.6e-51 175.5 15.3 3.4e-47 161.3 15.3 2.2 1 1 0 1 1 1 1 ZIP Zinc transporter ThrE PF06738.12 CCL98503.1 - 1.6e-43 148.8 9.9 1.6e-43 148.8 9.9 2.3 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 CCL98503.1 - 2e-06 28.0 8.1 2e-06 28.0 8.1 2.4 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE DUF2964 PF11177.8 CCL98503.1 - 0.081 13.1 0.6 0.27 11.5 0.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2964) SNF2_N PF00176.23 CCL98504.1 - 6.3e-67 225.8 0.0 1.2e-66 224.9 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCL98504.1 - 1e-13 51.6 0.0 2.3e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 CCL98504.1 - 8.3e-05 22.5 2.2 0.0002 21.2 2.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCL98504.1 - 0.0095 15.8 1.9 0.027 14.3 1.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 CCL98504.1 - 0.035 14.1 0.0 0.98 9.4 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit zf-RING_2 PF13639.6 CCL98504.1 - 0.18 12.1 5.2 0.72 10.2 0.2 2.6 2 0 0 2 2 2 0 Ring finger domain Rtf2 PF04641.12 CCL98504.1 - 0.31 10.4 2.8 0.23 10.8 0.1 2.0 2 0 0 2 2 2 0 Rtf2 RING-finger zf-RING_UBOX PF13445.6 CCL98504.1 - 0.32 11.1 4.3 0.34 11.0 2.6 2.0 1 1 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 CCL98504.1 - 0.38 10.6 2.3 0.97 9.3 2.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCL98504.1 - 9.3 6.2 6.8 0.49 10.3 0.5 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ribonucleas_3_3 PF14622.6 CCL98505.1 - 7.1e-09 35.9 0.0 1.1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 CCL98505.1 - 1e-06 29.3 0.1 2.4e-06 28.1 0.1 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 CCL98505.1 - 0.00029 21.4 0.0 0.001 19.7 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease III domain SNF2_N PF00176.23 CCL98506.1 - 7.1e-56 189.4 0.2 1.2e-55 188.7 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCL98506.1 - 1.2e-19 70.7 0.0 3.7e-19 69.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CCL98506.1 - 3.4e-16 59.3 0.3 7.6e-16 58.1 0.3 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 zf-PHD-like PF15446.6 CCL98506.1 - 6.2e-07 29.2 0.6 3.7e-05 23.4 0.0 3.2 3 0 0 3 3 3 1 PHD/FYVE-zinc-finger like domain ResIII PF04851.15 CCL98506.1 - 8.6e-07 29.1 0.0 2.7e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Chromo PF00385.24 CCL98506.1 - 0.011 15.6 0.3 0.31 11.0 0.0 2.7 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain AAA_19 PF13245.6 CCL98506.1 - 0.064 13.6 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNAse_A_bac PF18431.1 CCL98506.1 - 0.15 13.0 0.4 0.68 10.9 0.4 2.1 1 0 0 1 1 1 0 Bacterial CdiA-CT RNAse A domain zinc_ribbon_5 PF13719.6 CCL98506.1 - 0.3 10.9 1.5 0.44 10.3 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain PHD PF00628.29 CCL98506.1 - 9.9 6.1 10.9 7.3 6.6 0.1 3.8 4 0 0 4 4 4 0 PHD-finger Sec8_exocyst PF04048.14 CCL98507.1 - 3.3e-30 104.8 0.3 3.5e-29 101.5 0.0 2.4 1 1 1 2 2 2 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 CCL98507.1 - 1.1e-06 28.2 0.1 2.4e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Arf PF00025.21 CCL98507.1 - 0.12 11.8 0.7 0.25 10.8 0.7 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF4653 PF15546.6 CCL98507.1 - 0.52 9.9 4.3 2.5 7.7 1.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4653) Baculo_ODV-E27 PF05314.11 CCL98508.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 2 0 0 2 2 2 0 Baculovirus occlusion-derived virus envelope protein EC27 Cellulase PF00150.18 CCL98509.1 - 2e-41 142.3 0.5 2.6e-41 141.9 0.5 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cellulase PF00150.18 CCL98510.1 - 7.2e-45 153.6 0.0 9.5e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF1759 PF03564.15 CCL98510.1 - 0.032 14.2 0.0 0.075 13.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) F-box_5 PF18511.1 CCL98510.1 - 0.15 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 F-box MMR_HSR1 PF01926.23 CCL98511.1 - 1.9e-15 56.9 0.0 2.1e-14 53.6 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCL98511.1 - 1.9e-05 24.3 0.1 0.00012 21.7 0.1 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCL98511.1 - 2e-05 24.5 0.0 0.0087 16.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 CCL98511.1 - 0.0032 16.8 0.0 0.013 14.9 0.1 1.9 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 CCL98511.1 - 0.021 14.9 0.1 0.057 13.5 0.1 1.8 1 0 0 1 1 1 0 Dynamin family Pkinase PF00069.25 CCL98512.1 - 1e-42 146.3 0.0 1.4e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98512.1 - 2.5e-27 95.8 0.0 3.3e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 CCL98512.1 - 1.3e-12 47.8 0.1 2.8e-12 46.8 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCL98512.1 - 1.1e-05 25.6 0.0 2.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Haspin_kinase PF12330.8 CCL98512.1 - 0.088 11.7 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CCL98512.1 - 0.17 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SpoVR PF04293.13 CCL98512.1 - 0.23 10.1 0.0 0.37 9.4 0.0 1.3 1 0 0 1 1 1 0 SpoVR like protein Esterase PF00756.20 CCL98513.1 - 2.8e-39 135.3 0.0 3.4e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 CCL98513.1 - 0.022 13.7 0.0 0.046 12.6 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme PGAP1 PF07819.13 CCL98514.1 - 5.4e-06 26.3 0.0 5.4e-06 26.3 0.0 1.5 2 0 0 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 CCL98514.1 - 2.6e-05 24.2 0.0 4.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 CCL98514.1 - 0.00013 21.7 0.2 0.00059 19.6 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL98514.1 - 0.00023 21.9 0.3 0.00034 21.3 0.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 CCL98514.1 - 0.00055 19.3 0.0 0.0013 18.1 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 CCL98514.1 - 0.0037 16.8 0.0 0.012 15.1 0.0 1.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.15 CCL98514.1 - 0.008 15.4 0.0 0.012 14.8 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 CCL98514.1 - 0.014 14.7 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Lipase_3 PF01764.25 CCL98514.1 - 0.064 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Choline_kinase PF01633.20 CCL98514.1 - 0.12 12.0 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase AAA_5 PF07728.14 CCL98515.1 - 2.8e-120 396.7 0.0 1.5e-19 70.4 0.0 9.7 8 1 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 CCL98515.1 - 1.1e-47 160.6 10.2 2.8e-17 62.8 0.0 5.6 5 0 0 5 5 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 CCL98515.1 - 6.3e-26 90.5 0.0 6.2e-25 87.3 0.0 2.6 2 0 0 2 2 2 1 Midasin AAA lid domain AAA PF00004.29 CCL98515.1 - 8.6e-25 87.7 0.3 0.00019 21.8 0.0 6.8 7 0 0 7 7 6 5 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 CCL98515.1 - 1.5e-24 86.3 0.0 1.2e-07 31.7 0.0 7.5 7 0 0 7 7 7 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CCL98515.1 - 2.9e-22 79.1 0.5 5.4e-05 22.8 0.0 6.5 6 0 0 6 6 6 4 P-loop containing dynein motor region AAA_16 PF13191.6 CCL98515.1 - 9.4e-22 78.2 17.2 0.00024 21.5 0.0 9.0 7 1 0 7 7 7 5 AAA ATPase domain Dynein_heavy PF03028.15 CCL98515.1 - 6.9e-18 64.9 0.0 0.0048 17.0 0.0 6.7 5 0 0 5 5 5 4 Dynein heavy chain region D6 P-loop domain Sigma54_activat PF00158.26 CCL98515.1 - 1.7e-17 63.6 0.0 0.0048 16.6 0.0 5.9 6 0 0 6 6 5 3 Sigma-54 interaction domain AAA_22 PF13401.6 CCL98515.1 - 8.7e-17 61.7 3.8 0.0083 16.4 0.1 7.5 7 0 0 7 7 7 4 AAA domain AAA_6 PF12774.7 CCL98515.1 - 1.9e-16 60.0 0.0 0.013 14.5 0.1 7.1 9 0 0 9 9 7 4 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 CCL98515.1 - 5.9e-15 56.0 0.3 0.007 16.9 0.0 6.1 5 0 0 5 5 5 3 AAA domain AAA_30 PF13604.6 CCL98515.1 - 4.3e-14 52.7 0.0 0.0013 18.5 0.0 6.4 6 1 0 6 6 5 2 AAA domain ABC_tran PF00005.27 CCL98515.1 - 6.2e-12 46.2 1.9 0.082 13.4 0.0 6.1 6 0 0 6 6 4 3 ABC transporter Sigma54_activ_2 PF14532.6 CCL98515.1 - 2.2e-11 44.0 0.2 0.00084 19.5 0.0 5.3 5 0 0 5 5 5 2 Sigma-54 interaction domain TsaE PF02367.17 CCL98515.1 - 5.4e-11 42.6 0.3 1.2 9.1 0.0 5.7 5 0 0 5 5 5 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CCL98515.1 - 5.7e-11 42.6 0.0 0.041 13.9 0.0 7.8 9 0 0 9 9 7 2 AAA domain AAA_28 PF13521.6 CCL98515.1 - 1.1e-09 38.8 6.6 1.1 9.5 0.0 6.5 6 0 0 6 6 5 3 AAA domain AAA_8 PF12780.7 CCL98515.1 - 4e-08 32.9 0.2 0.42 9.9 0.0 5.3 5 0 0 5 5 5 2 P-loop containing dynein motor region D4 NACHT PF05729.12 CCL98515.1 - 6e-08 32.8 0.3 2 8.3 0.0 5.3 5 0 0 5 5 4 2 NACHT domain AAA_29 PF13555.6 CCL98515.1 - 6.3e-08 32.2 3.1 0.55 10.0 0.1 6.7 7 0 0 7 7 7 1 P-loop containing region of AAA domain RuvB_N PF05496.12 CCL98515.1 - 7.2e-08 32.3 2.2 1.3 8.7 0.0 6.6 7 0 0 7 7 6 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CCL98515.1 - 8.8e-08 31.8 1.4 8.7 5.7 0.0 7.9 9 0 0 9 9 8 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CCL98515.1 - 1e-07 32.4 6.4 0.65 10.3 0.0 6.6 8 0 0 8 8 5 2 AAA domain T2SSE PF00437.20 CCL98515.1 - 1.3e-07 30.9 0.5 0.18 10.9 0.0 5.2 6 0 0 6 6 6 2 Type II/IV secretion system protein Zeta_toxin PF06414.12 CCL98515.1 - 1.9e-07 30.6 0.0 3.4 6.9 0.0 6.2 6 0 0 6 6 6 1 Zeta toxin AAA_33 PF13671.6 CCL98515.1 - 2.9e-07 30.7 0.1 8.5 6.5 0.0 6.0 5 0 0 5 5 5 0 AAA domain DUF815 PF05673.13 CCL98515.1 - 4e-07 29.4 0.2 1.1 8.4 0.0 4.8 5 0 0 5 5 5 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 CCL98515.1 - 4.1e-07 30.4 0.3 12 6.3 0.0 6.2 7 0 0 7 7 5 0 RNA helicase AAA_25 PF13481.6 CCL98515.1 - 3.4e-06 26.8 8.2 1.5 8.4 0.2 6.0 6 0 0 6 6 5 1 AAA domain RsgA_GTPase PF03193.16 CCL98515.1 - 5e-06 26.5 0.5 3.5 7.5 0.1 4.5 4 0 0 4 4 4 0 RsgA GTPase PduV-EutP PF10662.9 CCL98515.1 - 2.1e-05 24.3 0.1 0.34 10.6 0.0 4.6 5 0 0 5 5 4 1 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.22 CCL98515.1 - 5.2e-05 22.9 0.1 14 5.3 0.0 4.7 5 0 0 5 5 4 0 SRP54-type protein, GTPase domain Roc PF08477.13 CCL98515.1 - 0.00011 22.4 1.0 17 5.7 0.0 4.7 5 0 0 5 5 4 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 CCL98515.1 - 0.00018 22.1 0.1 26 5.2 0.0 5.2 5 0 0 5 5 5 0 AAA domain AAA_24 PF13479.6 CCL98515.1 - 0.00065 19.5 0.1 9.3 5.9 0.0 4.9 5 0 0 5 5 4 0 AAA domain Rad17 PF03215.15 CCL98515.1 - 0.0011 19.0 2.9 16 5.3 0.0 5.7 6 0 0 6 6 6 0 Rad17 P-loop domain dNK PF01712.19 CCL98515.1 - 0.0011 18.8 0.7 17 5.2 0.0 4.4 4 0 0 4 4 4 0 Deoxynucleoside kinase TniB PF05621.11 CCL98515.1 - 0.0018 17.7 0.7 3 7.2 0.0 4.8 6 0 0 6 6 4 1 Bacterial TniB protein IstB_IS21 PF01695.17 CCL98515.1 - 0.0025 17.6 0.3 30 4.3 0.0 4.7 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_11 PF13086.6 CCL98515.1 - 0.0041 16.9 0.3 12 5.5 0.0 5.3 6 0 0 6 6 5 0 AAA domain CbiA PF01656.23 CCL98515.1 - 0.0041 17.2 0.1 0.38 10.8 0.0 3.8 4 0 0 4 4 4 1 CobQ/CobB/MinD/ParA nucleotide binding domain Viral_helicase1 PF01443.18 CCL98515.1 - 0.0083 15.9 0.8 2.2 8.0 0.0 4.3 6 0 0 6 6 4 1 Viral (Superfamily 1) RNA helicase AAA_21 PF13304.6 CCL98515.1 - 0.0096 15.8 0.1 0.85 9.4 0.0 3.6 4 0 0 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system NTPase_1 PF03266.15 CCL98515.1 - 0.012 15.6 2.4 10 6.0 0.0 4.5 4 0 0 4 4 4 0 NTPase cobW PF02492.19 CCL98515.1 - 0.018 14.6 1.7 82 2.7 0.0 4.7 5 0 0 5 5 4 0 CobW/HypB/UreG, nucleotide-binding domain DEAD PF00270.29 CCL98515.1 - 0.021 14.6 0.1 17 5.1 0.0 3.7 4 0 0 4 4 3 0 DEAD/DEAH box helicase SRPRB PF09439.10 CCL98515.1 - 0.034 13.6 0.5 24 4.3 0.0 4.5 5 0 0 5 5 5 0 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 CCL98515.1 - 0.064 13.0 2.8 4.2 7.1 0.0 3.8 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein ResIII PF04851.15 CCL98515.1 - 0.073 13.1 0.0 13 5.7 0.0 3.3 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit MMR_HSR1 PF01926.23 CCL98515.1 - 0.1 12.7 1.9 23 5.1 0.0 4.6 5 0 0 5 5 4 0 50S ribosome-binding GTPase ATPase PF06745.13 CCL98515.1 - 0.13 11.6 0.6 14 4.9 0.0 3.2 3 0 0 3 3 2 0 KaiC PhoH PF02562.16 CCL98515.1 - 0.21 11.0 0.3 21 4.5 0.0 3.4 3 0 0 3 3 3 0 PhoH-like protein Sugar_tr PF00083.24 CCL98516.1 - 4e-17 62.2 15.2 2.3e-13 49.8 4.6 3.1 1 1 2 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.16 CCL98516.1 - 8.2e-14 51.3 38.5 4.7e-13 48.8 34.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase_fungal PF17667.1 CCL98517.1 - 2.2e-12 46.5 0.0 3.1e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Avl9 PF09794.9 CCL98519.1 - 6.1e-124 413.6 0.0 8e-124 413.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 CCL98519.1 - 2.6e-10 40.3 1.7 0.00018 21.2 1.4 3.2 2 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 CCL98519.1 - 8.8e-09 35.3 0.0 0.00069 19.6 0.0 2.4 2 0 0 2 2 2 2 Stabilization of polarity axis Afi1 PF07792.12 CCL98519.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking COesterase PF00135.28 CCL98520.1 - 7e-88 295.7 0.0 1.6e-87 294.5 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CCL98520.1 - 0.00078 19.0 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCL98520.1 - 0.0015 18.5 0.3 0.011 15.5 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold STE3 PF02076.15 CCL98521.1 - 2.7e-93 312.4 21.0 3.2e-93 312.1 21.0 1.1 1 0 0 1 1 1 1 Pheromone A receptor DUF3421 PF11901.8 CCL98522.1 - 3.1e-28 98.0 0.1 4.6e-17 62.1 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) DUF1974 PF09317.11 CCL98522.1 - 0.055 13.0 0.0 0.084 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) Mus7 PF09462.10 CCL98524.1 - 1.3e-67 229.1 1.7 4.3e-67 227.4 1.8 1.8 2 1 0 2 2 2 1 Mus7/MMS22 family Hydrolase_4 PF12146.8 CCL98525.1 - 6.9e-08 32.0 0.0 6e-07 29.0 0.0 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DRMBL PF07522.14 CCL98525.1 - 3e-07 30.6 0.0 1e-06 28.9 0.0 1.9 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Abhydrolase_6 PF12697.7 CCL98525.1 - 1.2e-06 29.3 1.0 3.2e-06 27.9 1.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 CCL98525.1 - 2e-06 27.7 0.0 4.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_3 PF07859.13 CCL98525.1 - 0.00099 19.0 0.0 0.0023 17.8 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CCL98525.1 - 0.0012 18.5 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 CCL98525.1 - 0.008 16.3 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain DUF1749 PF08538.10 CCL98525.1 - 0.13 11.3 0.0 10 5.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Ribosomal_L33 PF00471.20 CCL98526.1 - 5.1e-07 30.0 0.0 6.5e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L33 Ebp2 PF05890.12 CCL98529.1 - 1.3e-88 297.1 10.1 1.5e-88 296.8 10.1 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Sororin PF09666.10 CCL98532.1 - 0.044 14.0 0.6 0.12 12.6 0.1 1.9 2 0 0 2 2 2 0 Sororin protein Glyco_hydro_28 PF00295.17 CCL98533.1 - 2e-34 119.1 1.5 2.4e-34 118.8 1.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CCL98533.1 - 0.01 15.7 5.9 0.01 15.7 5.9 2.8 1 1 1 3 3 3 0 Right handed beta helix region AAA_11 PF13086.6 CCL98536.1 - 2.1e-25 90.0 0.0 1.7e-24 87.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCL98536.1 - 3.6e-10 39.9 0.0 3.6e-06 26.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCL98536.1 - 4.4e-09 36.8 0.0 1.7e-07 31.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 CCL98536.1 - 4.9e-09 36.1 0.0 9.9e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCL98536.1 - 0.0036 17.7 0.0 0.03 14.7 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CCL98536.1 - 0.029 14.8 0.1 0.11 12.9 0.0 2.2 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 CCL98536.1 - 0.034 13.7 0.0 0.92 9.0 0.0 2.6 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_14 PF13173.6 CCL98536.1 - 0.034 14.2 0.0 1.8 8.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CCL98536.1 - 0.052 13.6 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCL98536.1 - 0.11 12.8 0.1 0.55 10.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 CCL98536.1 - 0.2 11.7 1.1 1.5 8.8 0.0 2.8 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit MFS_1 PF07690.16 CCL98538.1 - 4.4e-36 124.5 48.6 4.4e-36 124.5 48.6 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCL98538.1 - 1.5e-20 73.2 12.9 1.5e-20 73.2 12.9 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCL98538.1 - 2.5e-16 59.6 13.2 2.5e-16 59.6 13.2 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter DUF3522 PF12036.8 CCL98538.1 - 0.23 11.7 4.0 0.14 12.4 0.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) DUF3959 PF13105.6 CCL98538.1 - 0.31 10.5 1.3 0.62 9.5 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) OATP PF03137.20 CCL98538.1 - 0.98 7.6 14.6 0.25 9.6 1.0 3.2 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Xpo1 PF08389.12 CCL98539.1 - 7.5e-05 22.8 0.1 0.00097 19.2 0.0 2.8 2 0 0 2 2 2 1 Exportin 1-like protein ParcG PF10274.9 CCL98539.1 - 0.00022 21.4 0.2 0.11 12.6 0.0 3.3 3 0 0 3 3 3 1 Parkin co-regulated protein Adaptin_N PF01602.20 CCL98539.1 - 0.00053 18.7 0.3 0.027 13.0 0.0 2.3 2 0 0 2 2 2 2 Adaptin N terminal region HEAT PF02985.22 CCL98539.1 - 0.0068 16.6 0.7 0.78 10.2 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat API5 PF05918.11 CCL98539.1 - 0.024 13.5 0.2 0.047 12.5 0.0 1.4 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) CAS_CSE1 PF03378.15 CCL98539.1 - 0.037 12.5 0.0 0.14 10.6 0.0 2.0 2 0 0 2 2 2 0 CAS/CSE protein, C-terminus HEAT_2 PF13646.6 CCL98539.1 - 0.072 13.5 0.5 0.87 10.0 0.1 3.1 2 1 0 2 2 2 0 HEAT repeats TRI5 PF06330.11 CCL98540.1 - 2.8e-11 42.9 0.1 4.2e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) UL42 PF17638.2 CCL98540.1 - 1.3 9.0 5.1 3.9 7.5 5.1 1.8 1 0 0 1 1 1 0 HCMV UL42 TRI5 PF06330.11 CCL98541.1 - 3.1e-16 59.2 0.2 4.1e-16 58.8 0.2 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) TRI5 PF06330.11 CCL98542.1 - 2.2e-18 66.2 0.0 2.9e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) p450 PF00067.22 CCL98543.1 - 6.9e-39 133.9 0.0 3.6e-38 131.5 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 Dus PF01207.17 CCL98544.1 - 1.2e-46 159.3 0.0 1.6e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) F-box-like PF12937.7 CCL98546.1 - 9.9e-07 28.6 0.1 2e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 F-box-like Pyridox_oxase_2 PF12766.7 CCL98547.1 - 1.1e-19 70.9 0.0 1.9e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CCL98547.1 - 3.3e-05 24.0 0.0 5.8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase TRI5 PF06330.11 CCL98549.1 - 1.8e-15 56.7 0.1 2.2e-15 56.4 0.1 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) Phage_AlpA PF05930.12 CCL98549.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Prophage CP4-57 regulatory protein (AlpA) HpcH_HpaI PF03328.14 CCL98551.1 - 2.5e-29 102.0 0.0 3e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PK PF00224.21 CCL98551.1 - 0.11 11.3 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain MUG113 PF13455.6 CCL98551.1 - 0.22 12.2 0.0 0.36 11.5 0.0 1.2 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 Pyridox_oxase_2 PF12766.7 CCL98552.1 - 1.6e-21 76.7 0.0 1e-20 74.2 0.0 2.1 2 1 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CCL98552.1 - 1.1e-08 35.1 0.0 2.4e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PX PF00787.24 CCL98553.1 - 0.00073 19.5 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 PX domain LEA_3 PF03242.13 CCL98554.1 - 0.051 14.3 1.0 1.6 9.5 0.0 2.4 2 0 0 2 2 2 0 Late embryogenesis abundant protein BTB PF00651.31 CCL98555.1 - 6.7e-06 26.3 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF4590 PF15257.6 CCL98555.1 - 0.021 14.8 0.1 0.042 13.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4590) ATG16 PF08614.11 CCL98556.1 - 0.22 11.7 7.3 0.46 10.7 6.7 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Cep57_CLD_2 PF14197.6 CCL98556.1 - 1.1 9.4 8.0 0.51 10.5 3.6 2.5 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 U79_P34 PF03064.16 CCL98557.1 - 0.097 12.0 1.2 0.23 10.8 1.2 1.5 2 0 0 2 2 2 0 HSV U79 / HCMV P34 Rib_recp_KP_reg PF05104.12 CCL98557.1 - 1.5 9.8 10.4 0.78 10.8 7.2 2.0 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region LRR_8 PF13855.6 CCL98558.1 - 2e-07 30.7 1.2 5.1e-07 29.4 1.2 1.7 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 CCL98558.1 - 5e-07 29.9 0.7 1.8e-06 28.2 0.2 2.2 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCL98558.1 - 0.24 11.5 4.8 7.7 6.9 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Glyco_hydro_16 PF00722.21 CCL98559.1 - 6.3e-35 120.2 0.1 8.1e-35 119.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 WD40 PF00400.32 CCL98560.1 - 1.7e-06 28.6 5.1 0.19 12.7 0.1 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat F-box-like PF12937.7 CCL98561.1 - 2.6e-11 43.2 0.5 1e-10 41.3 0.2 2.3 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 CCL98561.1 - 1.9 9.0 12.7 1e+02 3.5 3.0 5.1 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) Abhydrolase_1 PF00561.20 CCL98563.1 - 7.2e-20 71.7 0.1 4.5e-19 69.1 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCL98563.1 - 1.5e-19 70.0 0.0 2.5e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein S1-P1_nuclease PF02265.16 CCL98564.1 - 1.7e-42 146.0 0.0 8e-38 130.7 0.0 3.0 3 0 0 3 3 3 3 S1/P1 Nuclease Metallophos PF00149.28 CCL98565.1 - 3.8e-11 43.9 0.1 8.2e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCL98565.1 - 3.4e-06 27.4 0.1 0.0017 18.6 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Ribosomal_L23 PF00276.20 CCL98566.1 - 3.4e-07 30.5 0.0 7.7e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 DUF1977 PF09320.11 CCL98566.1 - 0.074 13.3 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1977) Rhomboid PF01694.22 CCL98567.1 - 2.3e-12 47.1 5.9 1.9e-11 44.2 4.4 2.8 2 1 0 2 2 2 1 Rhomboid family FinO_N PF12602.8 CCL98568.1 - 0.32 11.4 1.6 0.89 9.9 0.1 2.2 2 0 0 2 2 2 0 Fertility inhibition protein N terminal baeRF_family12 PF18856.1 CCL98568.1 - 1.4 9.5 3.3 7.9 7.1 0.6 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 Pkinase_fungal PF17667.1 CCL98569.1 - 2.1e-48 165.1 0.0 1.1e-47 162.7 0.0 1.9 1 1 0 1 1 1 1 Fungal protein kinase Fer4_7 PF12838.7 CCL98570.1 - 1.2e-06 29.0 0.8 2.3e-06 28.1 0.8 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CCL98570.1 - 4.6e-05 23.1 5.0 4.6e-05 23.1 5.0 1.8 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_16 PF13484.6 CCL98570.1 - 5.1e-05 24.1 2.6 0.00021 22.2 2.6 1.9 1 1 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 CCL98570.1 - 0.00012 22.1 0.5 0.00026 21.0 0.5 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CCL98570.1 - 0.00018 21.6 0.5 0.00032 20.8 0.5 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_4 PF12800.7 CCL98570.1 - 0.00038 20.7 1.9 0.00038 20.7 1.9 1.7 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 CCL98570.1 - 0.0005 20.0 5.4 0.0005 20.0 5.4 1.6 2 0 0 2 2 1 1 4Fe-4S binding domain Fer4_10 PF13237.6 CCL98570.1 - 0.0012 18.9 2.9 0.0031 17.6 3.0 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CCL98570.1 - 0.005 17.3 1.1 0.017 15.7 1.3 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CCL98570.1 - 0.0078 16.2 2.8 0.017 15.2 2.8 1.5 1 0 0 1 1 1 1 4Fe-4S binding domain Fer4_8 PF13183.6 CCL98570.1 - 0.021 15.3 2.3 0.054 13.9 2.3 1.8 1 1 0 1 1 1 0 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 CCL98570.1 - 0.17 12.1 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 c-SKI Smad4 binding domain Fer4_13 PF13370.6 CCL98570.1 - 0.77 10.4 5.5 0.92 10.1 4.3 1.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Prefoldin_2 PF01920.20 CCL98571.1 - 9.9e-25 86.5 1.6 1.2e-24 86.3 1.6 1.1 1 0 0 1 1 1 1 Prefoldin subunit Phage_Mu_Gam PF07352.12 CCL98571.1 - 0.0012 18.8 1.4 0.0016 18.4 1.4 1.2 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein LXG PF04740.12 CCL98571.1 - 0.0027 17.5 1.1 0.0099 15.6 0.4 1.9 2 0 0 2 2 2 1 LXG domain of WXG superfamily DASH_Dad3 PF08656.10 CCL98571.1 - 0.0037 17.3 0.2 0.0065 16.5 0.2 1.4 1 0 0 1 1 1 1 DASH complex subunit Dad3 AAA_32 PF13654.6 CCL98571.1 - 0.012 14.5 0.8 0.014 14.2 0.8 1.1 1 0 0 1 1 1 0 AAA domain Prefoldin PF02996.17 CCL98571.1 - 0.041 13.8 3.0 1.4 8.8 3.0 2.2 1 1 0 1 1 1 0 Prefoldin subunit PI3K_P85_iSH2 PF16454.5 CCL98571.1 - 0.045 13.3 4.0 0.14 11.8 1.1 2.0 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain APG6_N PF17675.1 CCL98571.1 - 0.12 12.9 5.0 5.5 7.5 3.8 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Syntaxin-6_N PF09177.11 CCL98571.1 - 0.12 12.9 1.9 0.23 12.0 1.9 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal JIP_LZII PF16471.5 CCL98571.1 - 0.19 11.9 2.1 3.2 8.0 0.5 2.2 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DivIC PF04977.15 CCL98571.1 - 0.28 11.0 3.0 0.19 11.5 0.6 1.8 2 0 0 2 2 2 0 Septum formation initiator DASH_Spc34 PF08657.10 CCL98571.1 - 0.29 10.9 3.8 3.6 7.3 0.9 2.1 1 1 0 2 2 2 0 DASH complex subunit Spc34 CLZ PF16526.5 CCL98571.1 - 0.38 11.1 3.2 0.52 10.7 0.7 2.2 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels OmpH PF03938.14 CCL98571.1 - 0.4 11.0 6.3 0.43 10.9 2.4 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Spc24 PF08286.11 CCL98571.1 - 0.54 10.5 3.9 1.1 9.5 3.1 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF3450 PF11932.8 CCL98571.1 - 0.84 8.9 5.4 0.55 9.5 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CAP PF00188.26 CCL98572.1 - 3.5e-14 53.7 1.2 7.4e-14 52.7 1.2 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SET PF00856.28 CCL98574.1 - 1.1e-10 42.2 0.0 1.1e-09 38.9 0.0 2.4 1 1 0 1 1 1 1 SET domain TPR_2 PF07719.17 CCL98574.1 - 0.002 18.1 5.0 0.32 11.2 1.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCL98574.1 - 0.013 16.0 0.6 2.1 8.9 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCL98574.1 - 0.022 15.6 1.4 0.23 12.4 0.3 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCL98574.1 - 0.031 14.1 5.5 0.54 10.2 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat YfiO PF13525.6 CCL98574.1 - 0.039 13.7 0.1 0.08 12.6 0.1 1.5 1 0 0 1 1 1 0 Outer membrane lipoprotein DUF1547 PF07577.11 CCL98574.1 - 0.044 14.2 0.1 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1547) TPR_11 PF13414.6 CCL98574.1 - 0.093 12.4 3.5 0.27 10.9 0.0 2.9 3 0 0 3 3 3 0 TPR repeat DNA_mis_repair PF01119.19 CCL98575.1 - 2.5e-15 56.2 0.0 1.6e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CCL98575.1 - 7e-08 32.4 0.0 1.8e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 CCL98575.1 - 1.4e-06 28.2 0.0 6.1e-05 22.8 0.0 2.8 2 1 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 CCL98575.1 - 0.00036 21.0 0.0 0.00084 19.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hist_deacetyl PF00850.19 CCL98576.1 - 6.7e-80 268.8 0.0 8.7e-80 268.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain WD40 PF00400.32 CCL98577.1 - 2.3e-105 341.6 80.1 1.1e-08 35.6 0.0 15.5 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98577.1 - 2.7e-24 85.3 15.0 0.048 14.0 0.1 12.3 1 1 11 12 12 12 6 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCL98577.1 - 3.4e-15 56.0 34.1 0.41 11.2 0.2 13.1 12 1 1 13 13 13 4 PQQ-like domain WD40_like PF17005.5 CCL98577.1 - 2.2e-14 53.5 0.6 0.028 13.8 0.0 5.5 1 1 5 6 6 6 4 WD40-like domain PD40 PF07676.12 CCL98577.1 - 1.3e-10 40.9 0.5 10 6.2 0.0 11.1 13 0 0 13 13 13 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CCL98577.1 - 2.5e-09 36.6 9.3 2.2 7.2 0.1 8.8 3 2 4 9 9 9 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 CCL98577.1 - 1.4e-06 27.9 5.4 12 6.0 0.0 7.2 8 0 0 8 8 8 0 PQQ enzyme repeat Frtz PF11768.8 CCL98577.1 - 7.9e-06 24.5 1.7 0.8 7.9 0.0 7.3 4 3 4 9 9 9 1 WD repeat-containing and planar cell polarity effector protein Fritz NACHT PF05729.12 CCL98577.1 - 2e-05 24.6 0.0 4.6e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Cytochrom_D1 PF02239.16 CCL98577.1 - 2.4e-05 23.1 29.9 0.098 11.2 1.3 6.3 1 1 4 7 7 7 6 Cytochrome D1 heme domain PQQ_2 PF13360.6 CCL98577.1 - 7.5e-05 22.4 31.1 0.0091 15.6 6.6 4.6 1 1 2 3 3 3 2 PQQ-like domain Nup160 PF11715.8 CCL98577.1 - 0.00018 20.3 25.8 0.44 9.1 0.0 8.6 4 3 4 11 11 11 3 Nucleoporin Nup120/160 AAA_16 PF13191.6 CCL98577.1 - 0.00019 21.9 0.0 0.00041 20.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain APS_kinase PF01583.20 CCL98577.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF1513 PF07433.11 CCL98577.1 - 0.37 9.8 14.8 3.8 6.5 0.2 5.9 2 2 1 5 5 5 0 Protein of unknown function (DUF1513) Choline_sulf_C PF12411.8 CCL98577.1 - 3.8 7.4 15.4 38 4.2 0.1 6.1 7 0 0 7 7 7 0 Choline sulfatase enzyme C terminal SBDS PF01172.18 CCL98578.1 - 5.3e-16 58.5 0.2 3.1e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF4471 PF14740.6 CCL98578.1 - 0.00037 19.8 0.0 0.00049 19.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) DAO PF01266.24 CCL98579.1 - 2e-43 149.3 4.7 2.5e-43 149.0 4.7 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCL98579.1 - 0.0015 17.8 0.1 0.038 13.2 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCL98579.1 - 0.003 17.7 0.1 0.0084 16.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCL98579.1 - 0.14 12.7 0.0 1.3 9.7 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCL98579.1 - 0.36 10.7 4.5 0.091 12.6 0.9 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Isochorismatase PF00857.20 CCL98580.1 - 8.3e-24 84.7 0.0 1.3e-23 84.1 0.0 1.3 1 1 0 1 1 1 1 Isochorismatase family DUF3663 PF12404.8 CCL98580.1 - 0.071 13.2 0.0 15 5.7 0.1 2.5 3 0 0 3 3 3 0 Peptidase AFG1_ATPase PF03969.16 CCL98581.1 - 1.4e-93 313.7 0.0 1.3e-89 300.6 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_22 PF13401.6 CCL98581.1 - 0.00023 21.4 0.0 0.001 19.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCL98581.1 - 0.00026 21.4 0.4 0.43 11.0 0.0 3.1 1 1 2 3 3 3 2 AAA ATPase domain AAA PF00004.29 CCL98581.1 - 0.01 16.3 0.0 0.052 14.0 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CCL98581.1 - 0.022 14.2 0.0 0.49 9.8 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 CCL98581.1 - 0.073 13.1 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 CCL98581.1 - 0.099 12.5 0.8 0.57 10.0 0.1 2.3 2 1 0 2 2 2 0 Bacterial dnaA protein NACHT PF05729.12 CCL98581.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.8 1 1 0 1 1 1 0 NACHT domain Glyco_hydro_53 PF07745.13 CCL98582.1 - 1e-76 258.2 0.0 1.2e-76 257.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 RNF220 PF15926.5 CCL98583.1 - 1.5e-22 80.4 7.9 3.1e-21 76.1 7.9 2.2 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 zf_UBZ PF18439.1 CCL98583.1 - 0.0012 18.4 0.0 0.2 11.3 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger Zn-C2H2_12 PF18112.1 CCL98583.1 - 0.0048 17.3 2.5 1.2 9.7 0.1 2.5 2 0 0 2 2 2 2 Autophagy receptor zinc finger-C2H2 domain PRP21_like_P PF12230.8 CCL98583.1 - 0.008 16.1 1.2 0.33 10.8 0.9 2.4 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein zf-ribbon_3 PF13248.6 CCL98583.1 - 0.011 15.2 2.7 2.3 7.8 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-CpG_bind_C PF12269.8 CCL98583.1 - 0.016 15.0 0.1 0.5 10.1 0.0 2.5 2 1 0 2 2 2 0 CpG binding protein zinc finger C terminal domain zf-Di19 PF05605.12 CCL98583.1 - 0.067 13.5 2.3 3.2 8.1 0.0 2.7 3 0 0 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding zf-dskA_traR PF01258.17 CCL98583.1 - 0.12 12.4 1.2 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger T4_baseplate PF12322.8 CCL98583.1 - 0.17 11.4 0.1 4.1 6.8 0.0 2.2 2 0 0 2 2 2 0 T4 bacteriophage base plate protein Zn-ribbon_8 PF09723.10 CCL98583.1 - 0.17 12.0 1.8 8 6.7 0.1 2.6 2 0 0 2 2 2 0 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 CCL98583.1 - 0.28 11.3 7.3 3.8 7.6 0.7 3.0 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Rad50_zn_hook PF04423.14 CCL98583.1 - 0.28 11.0 2.7 18 5.2 0.2 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif TF_Zn_Ribbon PF08271.12 CCL98583.1 - 0.28 10.7 2.0 14 5.3 0.6 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Zn_Tnp_IS1595 PF12760.7 CCL98583.1 - 0.35 10.9 1.7 28 4.8 0.1 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf_C2H2_10 PF18414.1 CCL98583.1 - 0.47 10.0 3.2 2.7 7.6 0.4 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger zf-C2H2_12 PF18658.1 CCL98583.1 - 0.68 9.5 3.5 4.1 7.0 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger C2H2-type DUF2116 PF09889.9 CCL98583.1 - 0.74 9.8 3.4 4.5 7.3 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Prok-RING_1 PF14446.6 CCL98583.1 - 0.83 9.6 2.7 5.4 7.0 0.5 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FYDLN_acid PF09538.10 CCL98583.1 - 9.5 7.0 13.3 1.2 9.8 2.0 3.7 2 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) Tom7 PF08038.12 CCL98584.1 - 2.3e-21 75.1 0.6 2.6e-21 75.0 0.6 1.0 1 0 0 1 1 1 1 TOM7 family JAB PF01398.21 CCL98585.1 - 3.4e-24 85.1 0.0 5.4e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CCL98585.1 - 8.9e-17 61.5 0.0 1.6e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 CCL98585.1 - 0.02 14.9 0.0 0.031 14.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) UreF PF01730.16 CCL98586.1 - 2e-13 51.1 0.0 2.9e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 UreF Vac14_Fig4_bd PF11916.8 CCL98587.1 - 4.1e-80 267.6 6.4 7.3e-80 266.8 6.4 1.4 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 CCL98587.1 - 1.2e-39 134.8 0.1 2.2e-36 124.4 0.0 3.9 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 CCL98587.1 - 1.7e-09 37.1 0.4 0.0056 16.8 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 CCL98587.1 - 1.9e-06 28.0 0.5 0.2 11.7 0.0 3.7 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CCL98587.1 - 0.00066 20.1 0.1 12 6.5 0.0 4.9 3 1 1 4 4 4 1 HEAT-like repeat ParcG PF10274.9 CCL98587.1 - 0.029 14.5 0.9 1.2 9.2 0.0 3.1 3 0 0 3 3 3 0 Parkin co-regulated protein WAPL PF07814.13 CCL98587.1 - 0.044 12.6 0.0 0.1 11.3 0.0 1.6 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin Arm PF00514.23 CCL98587.1 - 0.05 13.7 0.2 1.8 8.8 0.0 3.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Y_phosphatase3 PF13350.6 CCL98588.1 - 8.3e-63 212.5 0.0 9.4e-63 212.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 CCL98588.1 - 0.038 13.6 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCL98588.1 - 0.12 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CCL98588.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.7 1 1 0 1 1 1 0 Inositol hexakisphosphate MCM PF00493.23 CCL98589.1 - 3.3e-104 346.9 1.0 4.7e-104 346.4 0.3 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 CCL98589.1 - 5.5e-39 132.9 0.1 1e-38 132.1 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 CCL98589.1 - 2e-28 98.7 1.3 4.5e-28 97.6 1.3 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 CCL98589.1 - 1e-24 87.1 0.2 2.4e-24 85.9 0.2 1.7 1 0 0 1 1 1 1 MCM N-terminal domain MCM_lid PF17855.1 CCL98589.1 - 3.3e-24 85.1 0.9 3.3e-24 85.1 0.9 1.8 2 0 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 CCL98589.1 - 4.5e-07 29.5 0.0 4.4e-06 26.2 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCL98589.1 - 0.0015 18.4 0.0 0.004 17.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCL98589.1 - 0.0034 17.1 0.0 0.0077 16.0 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 CCL98589.1 - 0.022 14.7 0.0 0.079 13.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Fungal_trans PF04082.18 CCL98590.1 - 1e-14 54.3 0.4 1.7e-14 53.5 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box PF00646.33 CCL98591.1 - 0.00016 21.5 0.3 0.0099 15.7 0.0 3.2 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 CCL98591.1 - 0.0032 17.3 0.1 0.013 15.4 0.1 2.1 1 0 0 1 1 1 1 F-box-like PH_12 PF16457.5 CCL98594.1 - 2.4e-34 118.8 0.0 5.1e-34 117.7 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain ELMO_CED12 PF04727.13 CCL98594.1 - 6.4e-29 101.3 0.1 1.1e-28 100.5 0.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.8 CCL98594.1 - 4.3e-27 95.0 0.0 1e-26 93.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) TUG-UBL1 PF11470.8 CCL98594.1 - 0.007 16.6 0.1 0.23 11.7 0.0 2.8 2 0 0 2 2 2 1 TUG ubiquitin-like domain MTHFR PF02219.17 CCL98595.1 - 2.4e-104 348.7 0.0 3.7e-104 348.1 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase PseudoU_synth_1 PF01416.20 CCL98596.1 - 1.6e-06 28.5 0.0 0.00014 22.3 0.1 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase RNA_pol_Rpb4 PF03874.16 CCL98598.1 - 1.4e-16 61.0 0.2 1.8e-16 60.6 0.2 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb4 Aa_trans PF01490.18 CCL98599.1 - 2.8e-81 273.3 27.7 3.2e-81 273.2 27.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCL98599.1 - 0.00094 18.3 22.9 0.00094 18.3 22.9 1.8 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family SUZ PF12752.7 CCL98600.1 - 1.8e-15 57.4 1.6 1.8e-15 57.4 1.6 5.6 6 0 0 6 6 6 1 SUZ domain R3H PF01424.22 CCL98600.1 - 3e-05 23.9 1.0 4e-05 23.5 0.1 1.8 2 0 0 2 2 2 1 R3H domain DUF202 PF02656.15 CCL98602.1 - 0.0017 18.8 0.1 0.0099 16.3 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Asp PF00026.23 CCL98604.1 - 3.7e-24 85.7 0.1 6.8e-23 81.6 0.1 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease FGGY_C PF02782.16 CCL98605.1 - 3.3e-20 72.7 0.0 5.9e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CCL98605.1 - 3.5e-10 39.9 0.0 0.00081 19.0 0.0 2.4 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain DivIC PF04977.15 CCL98606.1 - 0.0077 16.0 4.1 0.0077 16.0 4.1 2.8 4 0 0 4 4 4 1 Septum formation initiator COG2 PF06148.11 CCL98606.1 - 0.24 11.5 3.2 0.33 11.0 1.4 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 CCL98606.1 - 1.1 9.9 8.1 1.1 9.9 0.2 3.2 3 1 0 3 3 3 0 Initiation control protein YabA Fez1 PF06818.15 CCL98606.1 - 1.7 9.1 12.9 0.027 15.0 3.0 2.4 1 1 1 2 2 2 0 Fez1 Uds1 PF15456.6 CCL98606.1 - 2.8 8.1 11.6 0.032 14.4 3.2 2.1 3 0 0 3 3 3 0 Up-regulated During Septation AAA_13 PF13166.6 CCL98606.1 - 8.3 4.9 11.3 13 4.3 11.3 1.2 1 0 0 1 1 1 0 AAA domain DUF4398 PF14346.6 CCL98606.1 - 8.9 7.0 18.1 1.5 9.5 1.6 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4398) PIF1 PF05970.14 CCL98608.1 - 1e-60 205.8 1.0 2.8e-46 158.4 0.2 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 CCL98608.1 - 6.4e-25 88.0 0.0 9.6e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCL98608.1 - 1.6e-11 44.7 0.0 2.9e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CCL98608.1 - 9.7e-05 20.5 0.2 0.00047 18.2 0.0 2.0 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.6 CCL98608.1 - 0.00019 21.2 0.0 0.00061 19.6 0.0 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 CCL98608.1 - 0.00045 20.5 0.0 0.0014 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCL98608.1 - 0.0017 18.1 0.3 2.8 7.6 0.1 3.2 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 CCL98608.1 - 0.0017 17.6 0.0 0.0036 16.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 CCL98608.1 - 0.005 16.4 0.0 0.027 14.0 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 CCL98608.1 - 0.0061 15.5 0.1 0.01 14.8 0.1 1.2 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain PhoH PF02562.16 CCL98608.1 - 0.01 15.3 0.0 0.032 13.7 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein SH3_13 PF18335.1 CCL98608.1 - 0.014 15.2 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain T2SSE PF00437.20 CCL98608.1 - 0.019 14.1 0.1 0.044 12.8 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 CCL98608.1 - 0.022 15.2 0.0 0.048 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DUF5605 PF18310.1 CCL98608.1 - 0.033 14.1 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) AAA PF00004.29 CCL98608.1 - 0.037 14.4 0.2 0.11 13.0 0.1 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CCL98608.1 - 0.038 13.7 0.0 5.3 6.7 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_29 PF13555.6 CCL98608.1 - 0.038 13.7 0.0 0.091 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 CCL98608.1 - 0.05 13.0 0.1 0.091 12.1 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_32 PF13654.6 CCL98608.1 - 0.053 12.3 0.0 0.089 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CCL98608.1 - 0.069 13.1 0.0 8.4 6.3 0.0 2.4 2 0 0 2 2 2 0 NTPase UvrD-helicase PF00580.21 CCL98608.1 - 0.12 11.8 0.2 0.19 11.2 0.2 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ATPase_2 PF01637.18 CCL98608.1 - 0.19 11.6 0.0 0.81 9.6 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Pkinase PF00069.25 CCL98609.1 - 5.4e-73 245.6 0.0 8.1e-73 245.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98609.1 - 5.8e-49 166.7 0.0 9.4e-49 166.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CCL98609.1 - 2.5e-23 82.2 0.1 6.3e-23 80.9 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 CCL98609.1 - 1e-05 24.5 0.3 2.3e-05 23.4 0.3 1.7 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCL98609.1 - 0.00049 19.5 0.0 0.0011 18.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCL98609.1 - 0.005 16.2 0.1 0.011 15.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCL98609.1 - 0.015 15.2 0.2 0.27 11.1 0.2 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.12 CCL98609.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 DSHCT (NUC185) domain TAN PF11640.8 CCL98610.1 - 1.2e-38 132.6 0.1 5e-38 130.6 0.1 2.2 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair PI3_PI4_kinase PF00454.27 CCL98610.1 - 3.3e-29 102.4 0.0 1e-17 64.8 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CCL98610.1 - 3.1e-07 30.1 0.1 1.2e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 FATC domain Rad9 PF04139.13 CCL98611.1 - 5.3e-49 166.9 0.0 7.7e-49 166.4 0.0 1.2 1 0 0 1 1 1 1 Rad9 Coatomer_E PF04733.14 CCL98612.1 - 1e-39 136.7 0.0 1.2e-39 136.5 0.0 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_2 PF07719.17 CCL98612.1 - 0.0044 17.0 0.0 10 6.5 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCL98612.1 - 0.0091 16.1 4.4 0.012 15.8 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCL98612.1 - 0.0094 16.1 0.0 2.1 8.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Cohesin_load PF10345.9 CCL98612.1 - 0.13 10.7 0.0 0.89 7.9 0.0 1.9 2 0 0 2 2 2 0 Cohesin loading factor TPR_19 PF14559.6 CCL98612.1 - 0.24 11.9 9.1 1.2 9.7 0.1 4.5 3 2 2 5 5 5 0 Tetratricopeptide repeat An_peroxidase PF03098.15 CCL98613.1 - 1.4e-37 129.5 0.0 1e-24 87.0 0.0 3.3 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 CCL98613.1 - 4.7e-05 22.3 0.0 0.00011 21.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome P450 zf-CSL PF05207.13 CCL98614.1 - 8.1e-14 51.1 1.0 1.9e-13 49.9 1.0 1.6 2 0 0 2 2 2 1 CSL zinc finger DnaJ PF00226.31 CCL98614.1 - 1.5e-12 47.5 0.0 2.7e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain SLC35F PF06027.12 CCL98615.1 - 1.2e-97 327.0 14.3 1.5e-97 326.8 14.3 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 CCL98615.1 - 1.7e-07 30.6 0.0 3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 CCL98615.1 - 0.022 14.9 22.2 0.18 12.0 7.2 3.2 3 1 0 3 3 3 0 EamA-like transporter family Deltameth_res PF16020.5 CCL98615.1 - 0.071 13.0 1.0 0.31 11.0 0.0 2.7 3 0 0 3 3 3 0 Deltamethrin resistance Wzy_C PF04932.15 CCL98615.1 - 2.2 7.9 10.1 5.9 6.5 0.4 2.9 2 1 1 3 3 3 0 O-Antigen ligase DNA_pol_phi PF04931.13 CCL98616.1 - 1 7.4 12.4 1.1 7.2 12.4 1.0 1 0 0 1 1 1 0 DNA polymerase phi PS_Dcarbxylase PF02666.15 CCL98617.1 - 1.8e-57 194.1 0.0 3e-57 193.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 CCL98617.1 - 1.6e-35 121.5 0.0 8.2e-19 67.8 0.1 2.5 2 0 0 2 2 2 2 C2 domain EF-hand_7 PF13499.6 CCL98617.1 - 0.0087 16.5 0.5 0.025 15.0 0.5 1.7 1 0 0 1 1 1 1 EF-hand domain pair MGC-24 PF05283.11 CCL98618.1 - 2.9 8.4 11.8 0.48 10.9 5.2 2.4 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TBPIP PF07106.13 CCL98619.1 - 1e-13 51.0 0.0 1.9e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain MscS_porin PF12795.7 CCL98619.1 - 0.015 14.8 3.0 0.021 14.4 3.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain HALZ PF02183.18 CCL98619.1 - 0.017 15.3 0.4 0.033 14.4 0.4 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper bZIP_1 PF00170.21 CCL98619.1 - 0.018 15.1 0.4 0.056 13.5 0.4 1.8 1 0 0 1 1 1 0 bZIP transcription factor DUF1319 PF07028.11 CCL98619.1 - 0.037 14.2 0.1 0.14 12.4 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Phage_GP20 PF06810.11 CCL98619.1 - 0.039 13.8 2.4 0.059 13.2 2.4 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 CENP-H PF05837.12 CCL98619.1 - 0.044 14.2 3.8 0.076 13.4 3.3 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) AAA_30 PF13604.6 CCL98619.1 - 0.055 13.2 2.6 0.46 10.2 2.0 2.1 1 1 0 2 2 2 0 AAA domain DivIC PF04977.15 CCL98619.1 - 0.084 12.6 2.4 0.44 10.3 2.4 2.2 1 1 0 1 1 1 0 Septum formation initiator ZapB PF06005.12 CCL98619.1 - 0.11 13.0 1.6 0.3 11.6 1.6 1.8 1 1 0 1 1 1 0 Cell division protein ZapB Mito_carr PF00153.27 CCL98620.1 - 4.8e-48 161.0 5.1 2.3e-19 69.1 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCL98620.1 - 0.00066 18.9 0.0 0.2 10.8 0.0 2.3 2 0 0 2 2 2 2 Gammaproteobacterial serine protease ADH_zinc_N PF00107.26 CCL98621.1 - 1.2e-14 54.4 0.0 2.2e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCL98621.1 - 2e-09 37.3 0.0 3.2e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCL98621.1 - 0.0017 19.4 0.0 0.0031 18.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCL98621.1 - 0.012 15.5 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Cu_amine_oxidN2 PF02727.16 CCL98621.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain ADH_zinc_N PF00107.26 CCL98622.1 - 1.7e-27 96.0 0.4 1.1e-13 51.3 0.0 2.4 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_N PF08240.12 CCL98622.1 - 2e-20 72.7 0.0 3.4e-10 39.8 0.0 2.5 2 0 0 2 2 2 2 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCL98622.1 - 0.00062 20.8 0.0 0.087 13.9 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase TctB PF07331.11 CCL98623.1 - 0.0014 18.9 0.7 0.0067 16.7 0.7 1.9 1 1 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family Aldose_epim PF01263.20 CCL98625.1 - 5.6e-20 71.8 0.0 1.5e-18 67.1 0.0 2.2 1 1 0 1 1 1 1 Aldose 1-epimerase Aldo_ket_red PF00248.21 CCL98626.1 - 8e-16 58.1 0.0 1.2e-15 57.5 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 CCL98628.1 - 7.8e-13 48.0 0.0 8.7e-13 47.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCL98629.1 - 1.8e-34 119.3 0.0 2.6e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCL98630.1 - 2.1e-72 244.4 0.0 2.6e-72 244.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2157 PF09925.9 CCL98630.1 - 0.83 9.4 5.3 0.55 10.0 0.5 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) TRI5 PF06330.11 CCL98631.1 - 0.023 13.6 0.1 0.046 12.6 0.1 1.5 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) p450 PF00067.22 CCL98632.1 - 1.8e-68 231.4 0.0 2.7e-68 230.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.21 CCL98633.1 - 2.2e-66 224.1 0.0 2.5e-66 223.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 CCL98634.1 - 6.8e-47 160.3 0.0 1.2e-45 156.2 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 HemeBinding_Shp PF11545.8 CCL98634.1 - 0.16 12.0 0.0 7.7 6.5 0.0 2.7 3 0 0 3 3 3 0 Cell surface heme-binding protein Shp Methyltransf_2 PF00891.18 CCL98636.1 - 1.7e-18 66.7 0.1 5.3e-16 58.6 0.0 2.9 2 1 0 2 2 2 2 O-methyltransferase domain Methyltransf_2 PF00891.18 CCL98637.1 - 4.3e-27 94.8 0.0 5.8e-26 91.1 0.0 2.2 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CCL98637.1 - 0.022 15.4 0.0 0.047 14.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 CCL98638.1 - 9.1e-24 83.9 0.1 6.4e-23 81.1 0.1 2.1 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CCL98638.1 - 8.5e-05 23.2 0.0 0.00024 21.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Dimerisation2 PF16864.5 CCL98638.1 - 0.002 18.1 0.1 0.045 13.7 0.0 2.3 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_12 PF08242.12 CCL98638.1 - 0.0052 17.5 0.0 0.011 16.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCL98638.1 - 0.0073 16.1 0.0 0.04 13.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCL98638.1 - 0.0086 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Rrf2 PF02082.20 CCL98638.1 - 0.12 12.7 0.0 0.59 10.5 0.0 2.2 3 0 0 3 3 3 0 Transcriptional regulator UPF0014 PF03649.13 CCL98639.1 - 1.4e-65 221.0 16.2 1.8e-65 220.7 16.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) Tubulin_2 PF13809.6 CCL98639.1 - 0.092 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Tubulin like GHMP_kinases_N PF00288.26 CCL98639.1 - 0.36 11.1 2.9 0.94 9.8 0.1 2.7 3 0 0 3 3 3 0 GHMP kinases N terminal domain DnaJ PF00226.31 CCL98640.1 - 2.4e-09 37.2 0.1 2.4e-09 37.2 0.1 1.9 2 0 0 2 2 2 1 DnaJ domain DUF4044 PF13253.6 CCL98640.1 - 0.0012 18.3 0.5 0.0017 17.8 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4044) Ala_racemase_N PF01168.20 CCL98641.1 - 7.3e-15 55.2 0.0 4.4e-14 52.6 0.0 1.9 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain DUF4743 PF15916.5 CCL98641.1 - 0.087 12.8 0.0 0.5 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4743) DUF4253 PF14062.6 CCL98641.1 - 0.16 12.1 0.0 1 9.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4253) DIOX_N PF14226.6 CCL98642.1 - 7.8e-16 58.9 0.0 1.3e-15 58.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCL98642.1 - 2.6e-14 53.5 0.0 7.1e-14 52.1 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Methyltransf_2 PF00891.18 CCL98643.1 - 4.5e-23 81.7 0.0 5.2e-22 78.2 0.0 2.3 1 1 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CCL98643.1 - 0.024 14.6 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain Methyltransf_25 PF13649.6 CCL98643.1 - 0.03 15.0 0.0 0.071 13.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CCL98643.1 - 0.066 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Aminotran_1_2 PF00155.21 CCL98644.1 - 4.3e-27 95.2 0.0 5.4e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCL98644.1 - 1.5e-14 53.7 0.0 2.2e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Pkinase PF00069.25 CCL98645.1 - 1.4e-49 168.9 0.0 4.2e-48 164.0 0.0 2.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98645.1 - 1.5e-29 103.1 0.1 3.2e-20 72.5 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCL98645.1 - 0.00066 18.6 0.1 0.00066 18.6 0.1 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CCL98645.1 - 0.0015 18.5 2.1 0.04 13.8 0.1 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CCL98645.1 - 0.013 14.8 0.2 3.8 6.7 0.0 2.6 3 0 0 3 3 3 0 Kinase-like RIO1 PF01163.22 CCL98645.1 - 0.054 13.1 0.2 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 RIO1 family EzrA PF06160.12 CCL98646.1 - 0.0029 15.9 13.7 0.0029 15.9 13.7 2.5 2 1 1 3 3 3 1 Septation ring formation regulator, EzrA DUF724 PF05266.14 CCL98646.1 - 0.0032 17.3 14.3 0.0032 17.3 14.3 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF724) MAD PF05557.13 CCL98646.1 - 0.016 13.6 30.6 0.029 12.8 30.6 1.3 1 0 0 1 1 1 0 Mitotic checkpoint protein Cob_adeno_trans PF01923.18 CCL98646.1 - 0.11 12.6 15.8 1.1 9.3 9.3 4.1 2 1 1 3 3 3 0 Cobalamin adenosyltransferase Baculo_PEP_C PF04513.12 CCL98646.1 - 0.15 12.1 1.0 0.4 10.7 1.0 1.7 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus IMCp PF12314.8 CCL98646.1 - 0.23 11.8 1.6 0.56 10.5 1.6 1.6 1 0 0 1 1 1 0 Inner membrane complex protein CENP-Q PF13094.6 CCL98646.1 - 0.83 9.8 27.4 0.35 11.1 7.7 3.0 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit TFIIE-A_C PF11521.8 CCL98646.1 - 1.4 9.3 13.1 8 6.8 2.8 4.2 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha COG5 PF10392.9 CCL98646.1 - 1.6 8.9 11.9 1.9 8.7 9.2 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 FliJ PF02050.16 CCL98646.1 - 3.6 7.8 32.4 0.15 12.3 20.9 3.0 3 0 0 3 3 2 0 Flagellar FliJ protein LMBR1 PF04791.16 CCL98646.1 - 4.1 6.2 12.5 7.5 5.3 12.5 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-F_leu_zip PF10473.9 CCL98646.1 - 5.2 7.1 35.9 1.1 9.3 19.3 3.5 4 0 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FliD_N PF02465.18 CCL98646.1 - 6 7.6 14.9 1.3 9.8 4.6 3.5 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus ATG16 PF08614.11 CCL98646.1 - 7.5 6.7 32.6 1.1 9.4 14.1 3.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ABC_trans_aux PF03886.13 CCL98647.1 - 0.0072 15.9 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 ABC-type transport auxiliary lipoprotein component Ribosomal_L1 PF00687.21 CCL98648.1 - 7.4e-58 195.6 0.6 1.2e-57 194.9 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF4805 PF16063.5 CCL98648.1 - 0.044 13.1 5.4 0.07 12.5 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) DFRP_C PF16543.5 CCL98649.1 - 2.1e-30 105.1 2.2 2.1e-30 105.1 2.2 3.7 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 CCL98649.1 - 1.4e-05 24.8 2.0 1.4e-05 24.8 2.0 2.4 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCL98649.1 - 3.1e-05 24.6 13.7 0.00024 21.8 4.5 3.4 2 1 1 3 3 3 2 Torus domain zf-CCCH_4 PF18044.1 CCL98649.1 - 0.00028 20.6 11.5 0.0013 18.5 3.1 3.3 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCL98649.1 - 0.00065 19.7 8.4 0.00065 19.7 8.4 3.2 3 0 0 3 3 3 2 Zinc finger domain Ndc1_Nup PF09531.10 CCL98649.1 - 0.038 12.7 1.1 0.052 12.2 1.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-CCCH_2 PF14608.6 CCL98649.1 - 1.2 9.7 10.9 2.2 8.9 5.2 2.8 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 CCL98649.1 - 6.7 7.0 12.2 0.59 10.4 1.4 3.0 2 1 0 3 3 3 0 Zinc-finger containing family Torus PF16131.5 CCL98650.1 - 8.5e-40 135.8 1.8 1.8e-39 134.8 1.8 1.5 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 CCL98650.1 - 4.2e-06 26.5 0.1 7.4e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCL98650.1 - 2.1e-05 24.4 0.1 3.9e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif bPH_6 PF10756.9 CCL98650.1 - 0.005 16.9 0.2 0.017 15.2 0.2 2.0 1 1 0 1 1 1 1 Bacterial PH domain zf_CCCH_4 PF18345.1 CCL98650.1 - 0.074 13.1 5.3 0.14 12.3 5.3 1.5 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 CCL98650.1 - 0.13 12.2 5.5 0.25 11.3 5.5 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCL98650.1 - 0.16 11.8 7.7 0.27 11.1 7.7 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger Bombesin PF02044.17 CCL98652.1 - 0.011 15.7 0.2 0.013 15.5 0.2 1.2 1 0 0 1 1 1 0 Bombesin-like peptide MDM31_MDM32 PF08118.11 CCL98653.1 - 2.2e-208 693.2 0.0 2.6e-208 693.0 0.0 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DUF2095 PF09868.9 CCL98653.1 - 0.18 11.8 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) MFS_1 PF07690.16 CCL98654.1 - 1.2e-28 100.0 38.2 5e-24 84.9 10.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCL98654.1 - 4.3e-05 22.5 4.8 4.3e-05 22.5 4.8 2.6 2 1 1 3 3 3 2 MFS_1 like family TRI12 PF06609.13 CCL98654.1 - 8.4e-05 21.2 0.8 0.00016 20.3 0.8 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Bax1-I PF01027.20 CCL98655.1 - 9.1e-50 169.4 25.7 1.1e-49 169.2 25.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 CCL98655.1 - 8.1e-05 22.3 15.6 0.00021 20.9 15.7 1.5 1 1 0 1 1 1 1 Bax inhibitor 1 like DUF2070 PF09843.9 CCL98655.1 - 3.4 5.8 15.0 4.3 5.5 15.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ELL PF10390.9 CCL98656.1 - 9.2e-06 25.4 0.0 9.2e-06 25.4 0.0 3.5 2 2 0 2 2 2 1 RNA polymerase II elongation factor ELL DUF2231 PF09990.9 CCL98657.1 - 0.26 11.7 3.8 0.24 11.8 0.6 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2231) PRIMA1 PF16101.5 CCL98658.1 - 5.4 7.1 8.9 0.97 9.5 1.9 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Pkinase_Tyr PF07714.17 CCL98659.1 - 3.8e-42 144.4 0.0 5.6e-42 143.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCL98659.1 - 3.1e-35 121.8 0.0 5e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 CCL98659.1 - 0.018 14.4 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCL98659.1 - 0.12 12.2 0.3 0.29 11.0 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family F-box-like PF12937.7 CCL98660.1 - 5.5e-08 32.6 0.4 1.3e-07 31.4 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCL98660.1 - 7.6e-08 32.0 1.2 2.2e-07 30.6 1.2 1.7 1 0 0 1 1 1 1 F-box domain Smr PF01713.21 CCL98661.1 - 1.1e-08 35.3 0.0 3.3e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 Smr domain Glyco_hydro_92 PF07971.12 CCL98662.1 - 5.6e-116 388.2 1.7 6.8e-116 387.9 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCL98662.1 - 9.9e-23 81.3 0.0 6.4e-22 78.6 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain HlyIII PF03006.20 CCL98663.1 - 9.3e-39 133.4 20.6 1.2e-38 133.0 20.6 1.2 1 0 0 1 1 1 1 Haemolysin-III related TssN PF17555.2 CCL98663.1 - 3.3 7.0 6.9 5.1 6.4 6.9 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN TFIID_20kDa PF03847.13 CCL98664.1 - 4.5e-28 97.5 0.3 8.6e-28 96.6 0.3 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 CCL98664.1 - 0.00011 22.4 0.0 0.0002 21.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCL98664.1 - 0.0013 19.1 0.1 0.014 15.8 0.0 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CCL98664.1 - 0.0019 18.2 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 CCL98664.1 - 0.077 13.1 0.1 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold PAC4 PF16093.5 CCL98664.1 - 0.27 11.4 5.7 0.21 11.8 1.3 2.8 3 0 0 3 3 3 0 Proteasome assembly chaperone 4 TFIIA PF03153.13 CCL98664.1 - 1.2 9.0 9.1 0.94 9.4 7.7 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RHD3 PF05879.12 CCL98665.1 - 2.3e-246 819.6 1.7 1.3e-245 817.2 1.7 1.8 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 CCL98665.1 - 1e-06 28.8 0.1 5.9e-06 26.4 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase GBP PF02263.19 CCL98665.1 - 3.4e-06 26.5 0.2 7.9e-06 25.3 0.2 1.6 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 CCL98665.1 - 2e-05 24.7 0.0 3.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 CCL98665.1 - 0.00072 19.8 0.0 0.0026 18.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain DUF3145 PF11343.8 CCL98665.1 - 0.08 12.5 0.1 0.18 11.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) Septin PF00735.18 CCL98665.1 - 0.081 12.2 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 Septin Roc PF08477.13 CCL98665.1 - 0.13 12.5 0.6 0.47 10.7 0.1 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 CCL98665.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B RNA_polI_A14 PF08203.11 CCL98666.1 - 0.0081 16.9 0.3 0.016 15.9 0.1 1.6 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 AFG1_ATPase PF03969.16 CCL98667.1 - 2.7e-49 168.0 0.0 1.1e-44 152.8 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase UTP25 PF06862.12 CCL98669.1 - 1.9e-166 554.5 0.0 2.3e-166 554.2 0.0 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Topoisom_bac PF01131.20 CCL98670.1 - 5.4e-105 351.8 0.0 7e-105 351.4 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CCL98670.1 - 3.5e-21 75.4 0.0 9e-21 74.0 0.0 1.7 1 0 0 1 1 1 1 Toprim domain zf-GRF PF06839.12 CCL98670.1 - 4.9e-12 45.7 8.5 7.8e-09 35.5 3.2 2.7 2 0 0 2 2 2 2 GRF zinc finger MMS1_N PF10433.9 CCL98671.1 - 1.6e-144 482.2 0.0 2.1e-144 481.8 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CCL98671.1 - 6e-94 315.0 0.0 3.9e-93 312.3 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region OsmC PF02566.19 CCL98672.1 - 2.1e-12 47.4 0.0 3.3e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein OsmC PF02566.19 CCL98673.1 - 8.1e-12 45.5 0.0 1.5e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 OsmC-like protein Nkap_C PF06047.11 CCL98674.1 - 7.6e-42 141.6 3.3 7.6e-42 141.6 3.3 2.6 3 0 0 3 3 3 1 NF-kappa-B-activating protein C-terminal domain FKBP_C PF00254.28 CCL98675.1 - 3.6e-34 117.0 0.0 4.4e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CHD5 PF04420.14 CCL98676.1 - 2.7e-26 92.3 0.6 3.9e-26 91.8 0.6 1.2 1 0 0 1 1 1 1 CHD5-like protein Ribosomal_L39 PF00832.20 CCL98676.1 - 4.1e-11 42.3 0.9 8.3e-11 41.3 0.9 1.5 1 0 0 1 1 1 1 Ribosomal L39 protein TRIQK PF15168.6 CCL98676.1 - 0.41 10.6 1.9 0.91 9.5 0.0 2.1 1 1 1 2 2 2 0 Triple QxxK/R motif-containing protein family Malate_synthase PF01274.22 CCL98677.1 - 2e-197 656.7 0.0 2.5e-197 656.3 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Pkinase PF00069.25 CCL98678.1 - 6.6e-18 65.0 0.0 2e-13 50.3 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98678.1 - 2.2e-12 46.8 0.0 5.5e-11 42.2 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 CCL98678.1 - 0.026 14.1 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family AMP-binding PF00501.28 CCL98680.1 - 2.9e-43 148.0 0.0 4.1e-43 147.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CCL98680.1 - 5.6e-09 35.8 0.2 1.2e-08 34.8 0.2 1.6 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CCL98680.1 - 0.025 15.6 0.0 0.12 13.3 0.0 2.1 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain TfuA PF07812.12 CCL98680.1 - 0.18 11.5 0.0 0.88 9.3 0.0 2.1 1 1 1 2 2 2 0 TfuA-like protein PALP PF00291.25 CCL98681.1 - 2.8e-55 187.8 0.8 2.8e-55 187.8 0.8 2.1 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.28 CCL98681.1 - 1.7e-25 90.0 0.9 3.4e-25 89.0 0.9 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCL98681.1 - 2.6e-18 65.9 0.1 2.6e-16 59.5 0.0 2.5 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCL98681.1 - 0.00088 19.0 1.0 0.0021 17.8 0.3 1.9 2 0 0 2 2 2 1 Peptidase family M28 ADH_zinc_N PF00107.26 CCL98681.1 - 0.0043 17.0 0.1 0.028 14.4 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF3510 PF12022.8 CCL98683.1 - 9.9e-32 110.0 0.0 3.7e-31 108.1 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) COG2 PF06148.11 CCL98683.1 - 1.1e-24 87.0 1.0 2.7e-24 85.7 0.3 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Imm71 PF15602.6 CCL98683.1 - 0.068 13.2 0.1 0.28 11.2 0.1 2.1 1 1 0 1 1 1 0 Immunity protein 71 Vps8 PF12816.7 CCL98684.1 - 5.1e-69 231.8 0.0 1.1e-66 224.2 0.0 2.8 3 0 0 3 3 3 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 CCL98684.1 - 1.5e-05 24.9 0.0 0.12 12.3 0.0 3.6 3 0 0 3 3 3 2 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 CCL98684.1 - 0.0034 17.6 0.0 0.29 11.4 0.0 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Cucumopine_C PF18631.1 CCL98684.1 - 0.065 13.2 0.1 12 5.8 0.0 2.8 2 0 0 2 2 2 0 Cucumopine synthase C-terminal helical bundle domain HBS1_N PF08938.10 CCL98684.1 - 1.9 8.8 4.2 5.2 7.4 2.1 2.5 2 0 0 2 2 2 0 HBS1 N-terminus PHD PF00628.29 CCL98685.1 - 1.8e-08 34.1 8.7 3e-08 33.4 8.7 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCL98685.1 - 2 8.1 6.3 1 8.9 4.0 1.7 2 0 0 2 2 2 0 PHD-finger PALP PF00291.25 CCL98686.1 - 5.9e-72 242.6 0.0 7.2e-72 242.3 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4597 PF15366.6 CCL98686.1 - 0.051 13.3 0.0 9 6.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) HU-HIG PF18291.1 CCL98686.1 - 0.077 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 HU domain fused to wHTH, Ig, or Glycine-rich motif Topoisom_I PF01028.20 CCL98687.1 - 4.2e-101 337.0 4.5 1e-100 335.7 4.5 1.7 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 CCL98687.1 - 8.6e-96 319.5 0.5 8.6e-96 319.5 0.5 3.0 3 1 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 CCL98687.1 - 2.4e-38 129.9 0.4 7.1e-38 128.4 0.4 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain TetR_C_23 PF17931.1 CCL98687.1 - 4.5 7.4 8.0 0.76 9.9 0.0 3.5 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain CTP_transf_1 PF01148.20 CCL98688.1 - 3.8e-74 249.8 20.4 5.7e-74 249.2 20.4 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Ribosom_S12_S23 PF00164.25 CCL98689.1 - 2.1e-41 140.1 1.7 5.9e-21 74.2 0.4 2.6 3 0 0 3 3 3 2 Ribosomal protein S12/S23 BRO1 PF03097.18 CCL98689.1 - 3.6e-21 75.4 0.0 5.3e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain PSD2 PF07624.11 CCL98689.1 - 0.38 10.6 1.3 1.2 9.0 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1585) DUF3506 PF12014.8 CCL98690.1 - 3.4e-10 40.1 0.3 4.6e-08 33.2 0.1 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF3506) F-box PF00646.33 CCL98690.1 - 0.00032 20.5 0.3 0.00072 19.4 0.3 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCL98690.1 - 0.045 13.7 1.9 0.09 12.7 1.9 1.6 1 0 0 1 1 1 0 F-box-like Glutaredoxin PF00462.24 CCL98692.1 - 7.6e-12 45.3 0.0 1.2e-10 41.5 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin GST_N_3 PF13417.6 CCL98692.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain HAD_2 PF13419.6 CCL98693.1 - 7.3e-17 62.0 0.0 1.9e-16 60.6 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCL98693.1 - 7.8e-11 42.7 0.1 1.2e-09 38.8 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CCL98693.1 - 1.4e-05 25.1 0.0 0.032 14.4 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CCL98693.1 - 1.8e-05 25.2 0.0 2.4e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCL98693.1 - 0.027 14.5 0.0 0.33 11.1 0.0 2.5 3 0 0 3 3 3 0 HAD-hyrolase-like Uma2 PF05685.12 CCL98693.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative restriction endonuclease PAP2_3 PF14378.6 CCL98694.1 - 0.03 14.0 0.1 0.045 13.4 0.1 1.2 1 0 0 1 1 1 0 PAP2 superfamily CHZ PF09649.10 CCL98697.1 - 1.6e-12 46.7 0.5 1.6e-12 46.7 0.5 3.2 2 2 1 3 3 3 1 Histone chaperone domain CHZ FAM176 PF14851.6 CCL98697.1 - 0.0079 15.9 5.7 0.0079 15.9 5.7 1.6 1 1 1 2 2 2 1 FAM176 family Sporozoite_P67 PF05642.11 CCL98697.1 - 0.54 8.3 3.9 0.47 8.5 3.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 CCL98697.1 - 1.1 7.4 8.1 1.1 7.4 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid_p PF12226.8 CCL98697.1 - 2.6 7.1 9.8 3.5 6.7 9.8 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.13 CCL98697.1 - 3.3 5.7 23.2 3.7 5.5 23.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi AAA_18 PF13238.6 CCL98699.1 - 4.6e-06 27.2 0.0 0.0017 18.9 0.0 2.5 2 1 1 3 3 3 1 AAA domain SKI PF01202.22 CCL98699.1 - 1.2e-05 25.5 0.0 0.00091 19.4 0.0 2.2 2 0 0 2 2 2 1 Shikimate kinase AAA_33 PF13671.6 CCL98699.1 - 3e-05 24.2 0.1 0.00076 19.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 CCL98699.1 - 0.0031 17.4 0.0 1.9 8.3 0.0 2.1 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_22 PF13401.6 CCL98699.1 - 0.0042 17.4 0.1 0.013 15.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CCL98699.1 - 0.006 17.0 0.3 0.015 15.7 0.1 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCL98699.1 - 0.0061 17.0 0.3 0.012 16.0 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 CCL98699.1 - 0.0067 16.7 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCL98699.1 - 0.0079 16.6 0.0 0.21 12.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCL98699.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCL98699.1 - 0.017 15.1 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Cytidylate_kin PF02224.18 CCL98699.1 - 0.026 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase T2SSE_N PF05157.15 CCL98699.1 - 0.043 14.1 0.0 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein E, N-terminal domain AAA_30 PF13604.6 CCL98699.1 - 0.047 13.4 0.1 0.082 12.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CCL98699.1 - 0.05 12.8 0.0 0.067 12.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 CCL98699.1 - 0.08 12.7 0.2 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 CCL98699.1 - 0.1 12.0 0.3 0.18 11.2 0.3 1.3 1 0 0 1 1 1 0 PhoH-like protein PduV-EutP PF10662.9 CCL98699.1 - 0.15 11.8 0.0 0.39 10.5 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Viral_helicase1 PF01443.18 CCL98699.1 - 0.21 11.3 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 CCL98699.1 - 0.21 10.7 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain ATP_bind_1 PF03029.17 CCL98699.1 - 0.24 11.2 0.1 0.37 10.5 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Asp PF00026.23 CCL98700.1 - 1.3e-39 136.5 5.0 2.8e-35 122.3 1.1 2.2 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCL98700.1 - 1.1e-09 38.8 0.8 2.5e-08 34.4 0.8 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCL98700.1 - 0.058 14.0 1.5 7 7.4 0.0 4.0 3 0 0 3 3 3 0 Aspartyl protease DUF2850 PF11012.8 CCL98700.1 - 0.092 13.1 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2850) TAXi_C PF14541.6 CCL98700.1 - 0.22 11.3 1.2 0.75 9.6 0.1 2.3 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal tify PF06200.14 CCL98700.1 - 0.39 10.1 2.3 37 3.8 0.0 3.2 3 0 0 3 3 3 0 tify domain Proteasome PF00227.26 CCL98701.1 - 1.4e-54 184.5 0.3 2.7e-54 183.5 0.3 1.5 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCL98701.1 - 1.5e-13 50.2 0.1 3.2e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ctr PF04145.15 CCL98702.1 - 9.4e-35 120.4 0.2 1.1e-34 120.2 0.2 1.1 1 0 0 1 1 1 1 Ctr copper transporter family UbiA PF01040.18 CCL98702.1 - 0.027 13.8 5.6 0.35 10.1 1.4 2.1 2 0 0 2 2 2 0 UbiA prenyltransferase family DUF4191 PF13829.6 CCL98702.1 - 4 6.7 5.4 0.7 9.2 1.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Rpr2 PF04032.16 CCL98703.1 - 1e-23 83.4 1.1 1.7e-23 82.7 1.1 1.4 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Mut7-C PF01927.16 CCL98703.1 - 0.0061 16.7 0.3 0.0085 16.2 0.3 1.3 1 0 0 1 1 1 1 Mut7-C RNAse domain CEBP1_N PF16368.5 CCL98703.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein 1 N-terminus Asp PF00026.23 CCL98704.1 - 2.4e-40 138.9 0.2 1.5e-39 136.3 0.2 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCL98704.1 - 1.5e-07 31.8 0.8 2.1e-05 24.8 0.1 2.7 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp PF00026.23 CCL98705.1 - 1.5e-26 93.6 0.4 6.7e-26 91.4 0.4 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCL98705.1 - 5e-05 23.6 0.2 0.00081 19.7 0.0 2.5 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCL98705.1 - 0.11 13.2 0.2 1.1 10.0 0.0 2.4 2 0 0 2 2 2 0 Aspartyl protease Peptidase_M26_C PF07580.14 CCL98706.1 - 0.0016 17.1 0.4 0.0017 17.0 0.4 1.1 1 0 0 1 1 1 1 M26 IgA1-specific Metallo-endopeptidase C-terminal region Med26 PF08711.11 CCL98706.1 - 0.0017 18.3 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 TFIIS helical bundle-like domain LSM PF01423.22 CCL98707.1 - 1.1e-14 53.9 0.2 1.4e-14 53.5 0.2 1.2 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.7 CCL98707.1 - 0.015 15.4 0.1 0.021 14.9 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain E3_binding PF02817.17 CCL98707.1 - 0.025 14.9 0.1 0.064 13.6 0.1 1.7 1 0 0 1 1 1 0 e3 binding domain SM-ATX PF14438.6 CCL98707.1 - 0.042 14.0 0.0 0.061 13.5 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Voltage_CLC PF00654.20 CCL98708.1 - 4.3e-89 299.2 21.1 4.3e-89 299.2 21.1 2.0 2 1 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CCL98708.1 - 0.14 12.6 0.0 0.69 10.4 0.0 2.1 2 0 0 2 2 2 0 CBS domain UCR_Fe-S_N PF10399.9 CCL98708.1 - 6 6.3 10.7 3.6 7.0 0.0 3.5 4 0 0 4 4 4 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal RIBIOP_C PF04950.12 CCL98709.1 - 1.7e-112 375.7 0.0 3.3e-112 374.7 0.0 1.5 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CCL98709.1 - 2.7e-17 62.6 0.0 2.3e-16 59.6 0.0 2.5 1 1 0 1 1 1 1 AARP2CN (NUC121) domain Vps53_N PF04100.12 CCL98710.1 - 1.6e-88 297.3 4.2 3.5e-88 296.1 4.2 1.6 1 0 0 1 1 1 1 Vps53-like, N-terminal VPS53_C PF16854.5 CCL98710.1 - 6.7e-06 26.1 5.0 1.4e-05 25.1 0.1 3.1 2 1 0 2 2 2 1 Vacuolar protein sorting-associated protein 53 C-terminus Vps54_N PF10475.9 CCL98710.1 - 3.3e-05 23.3 4.7 3.3e-05 23.3 4.7 1.9 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 CCL98710.1 - 0.00012 22.0 1.7 0.00047 20.0 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) DAGK_prokar PF01219.19 CCL98710.1 - 0.018 14.9 0.1 0.041 13.7 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic diacylglycerol kinase GP41 PF00517.17 CCL98710.1 - 0.07 13.0 1.0 0.18 11.7 1.0 1.6 1 0 0 1 1 1 0 Retroviral envelope protein Sec5 PF15469.6 CCL98710.1 - 0.48 10.2 8.0 0.37 10.6 3.5 2.6 2 0 0 2 2 2 0 Exocyst complex component Sec5 Rbsn PF11464.8 CCL98710.1 - 0.53 10.1 5.3 2.5 7.9 0.0 3.6 3 0 0 3 3 3 0 Rabenosyn Rab binding domain DUF1415 PF07209.12 CCL98710.1 - 1.2 8.9 3.7 8.9 6.0 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1415) ING PF12998.7 CCL98710.1 - 5.7 7.6 9.0 47 4.6 0.0 3.7 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF4795 PF16043.5 CCL98710.1 - 7.4 6.1 15.7 4.6 6.8 8.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) RRP36 PF06102.12 CCL98710.1 - 7.9 6.4 8.6 1.8 8.5 4.9 1.8 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 p450 PF00067.22 CCL98712.1 - 2.7e-60 204.5 0.0 7.3e-59 199.7 0.0 2.6 1 1 0 1 1 1 1 Cytochrome P450 Autophagy_N PF03986.13 CCL98712.1 - 1.6e-41 141.5 0.0 3.8e-41 140.2 0.0 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 CCL98712.1 - 2.2e-14 53.7 0.2 6.5e-14 52.3 0.2 1.9 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 CCL98712.1 - 3.7e-12 45.5 2.9 7.4e-12 44.6 2.9 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal FtsK_SpoIIIE PF01580.18 CCL98712.1 - 0.14 11.4 0.2 0.26 10.6 0.2 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family zf-LYAR PF08790.11 CCL98713.1 - 2.3e-15 56.2 1.0 4.6e-15 55.2 1.0 1.5 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger peroxidase PF00141.23 CCL98714.1 - 2.1e-43 148.7 0.0 3.6e-43 147.9 0.0 1.3 1 0 0 1 1 1 1 Peroxidase NOG1_N PF17835.1 CCL98715.1 - 8.4e-50 168.8 1.3 8.4e-50 168.8 1.3 1.7 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 CCL98715.1 - 9.2e-30 102.4 1.6 2.8e-29 100.9 1.6 1.9 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 CCL98715.1 - 9.1e-28 95.8 0.1 1.9e-27 94.8 0.1 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 CCL98715.1 - 1.5e-17 63.7 0.0 4e-17 62.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCL98715.1 - 2.6e-09 36.8 0.0 5.7e-09 35.7 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCL98715.1 - 0.0026 17.8 0.0 1.7 8.6 0.0 2.7 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 CCL98715.1 - 0.0051 16.7 0.1 1 9.2 0.0 3.0 2 1 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CCL98715.1 - 0.07 12.5 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Roc PF08477.13 CCL98715.1 - 0.076 13.2 0.0 1.2 9.4 0.0 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 CCL98715.1 - 0.084 12.3 0.1 6.5 6.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein HPP PF04982.13 CCL98718.1 - 2e-40 137.7 8.8 2e-40 137.7 8.8 1.5 2 0 0 2 2 2 1 HPP family CoA_transf_3 PF02515.17 CCL98720.1 - 6.8e-44 150.5 0.4 6e-40 137.5 0.1 2.3 2 1 0 2 2 2 2 CoA-transferase family III Histone PF00125.24 CCL98721.1 - 1.2e-23 83.9 3.2 1.6e-23 83.5 3.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCL98721.1 - 3.7e-05 23.9 0.1 3.7e-05 23.9 0.1 2.3 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CCL98721.1 - 0.00029 21.3 0.0 0.00056 20.4 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 CCL98721.1 - 0.037 14.1 0.2 0.043 13.8 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein RP-C PF03428.13 CCL98721.1 - 0.062 13.0 0.2 0.17 11.6 0.2 1.7 1 1 0 1 1 1 0 Replication protein C N-terminal domain Bt_P21 PF05560.11 CCL98721.1 - 0.11 12.1 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein Histone PF00125.24 CCL98722.1 - 5.1e-19 68.9 0.0 6.3e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CCL98722.1 - 5.5e-16 58.0 0.7 5.5e-16 58.0 0.7 1.7 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CCL98722.1 - 1.7e-06 28.2 0.0 2.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HECT_2 PF09814.9 CCL98723.1 - 5.5e-44 150.6 0.0 8.2e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding GRAB PF10375.9 CCL98724.1 - 8.7e-07 28.6 1.2 1.9e-06 27.5 1.2 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain GRIP PF01465.20 CCL98724.1 - 0.0034 17.2 0.0 0.0088 15.9 0.0 1.7 1 0 0 1 1 1 1 GRIP domain LPP PF04728.13 CCL98724.1 - 0.014 15.8 2.6 0.014 15.8 2.6 3.1 3 1 2 5 5 5 0 Lipoprotein leucine-zipper GldM_N PF12081.8 CCL98724.1 - 0.39 10.8 13.8 0.38 10.8 4.0 2.3 1 1 1 2 2 2 0 GldM N-terminal domain Golgin_A5 PF09787.9 CCL98724.1 - 0.46 9.9 47.0 1.3 8.4 13.5 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 ING PF12998.7 CCL98724.1 - 0.47 11.1 0.1 0.47 11.1 0.1 3.6 2 2 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding YfhO PF09586.10 CCL98724.1 - 0.72 8.0 2.1 0.82 7.8 2.1 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Bap31_Bap29_C PF18035.1 CCL98724.1 - 0.87 9.6 9.7 3.7 7.6 0.3 3.4 3 0 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain CENP-F_leu_zip PF10473.9 CCL98724.1 - 1.1 9.3 48.6 0.072 13.1 15.6 4.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CwsA PF10814.8 CCL98724.1 - 3.1 8.0 7.7 1.1 9.5 1.2 2.6 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA DUF3584 PF12128.8 CCL98724.1 - 3.5 5.0 40.3 6 4.2 40.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Zw10 PF06248.13 CCL98724.1 - 4.7 5.7 17.5 8 4.9 17.4 1.4 1 1 0 1 1 1 0 Centromere/kinetochore Zw10 Peptidase_C37 PF05416.12 CCL98724.1 - 6.5 5.1 11.2 3.9 5.9 8.8 1.7 1 1 1 2 2 2 0 Southampton virus-type processing peptidase WD40 PF00400.32 CCL98725.1 - 7.1e-11 42.5 4.1 0.00062 20.5 0.0 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98725.1 - 4.8e-06 26.8 0.0 0.13 12.6 0.0 4.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCL98725.1 - 0.0034 17.3 0.0 2.2 8.1 0.0 3.3 2 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Homoserine_dh PF00742.19 CCL98726.1 - 3.7e-47 160.5 0.0 4.8e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 CCL98726.1 - 1.5e-19 70.7 0.0 3.1e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CCL98726.1 - 0.019 15.4 0.0 0.24 11.9 0.0 2.5 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Histone PF00125.24 CCL98727.1 - 5.9e-26 91.4 3.6 7.1e-26 91.1 3.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCL98727.1 - 6.5e-06 26.3 0.1 6.5e-06 26.3 0.1 2.1 2 1 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CCL98727.1 - 0.0003 21.2 0.0 0.00055 20.4 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 CCL98727.1 - 0.017 15.1 0.2 0.02 14.9 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein Bt_P21 PF05560.11 CCL98727.1 - 0.084 12.5 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein RP-C PF03428.13 CCL98727.1 - 0.085 12.5 0.3 0.39 10.4 0.3 1.9 1 1 0 1 1 1 0 Replication protein C N-terminal domain DUF92 PF01940.16 CCL98729.1 - 1.1 8.7 6.0 12 5.2 5.0 2.3 1 1 0 1 1 1 0 Integral membrane protein DUF92 Amidase PF01425.21 CCL98730.1 - 3.4e-58 197.7 0.0 4e-44 151.3 0.0 3.0 1 1 2 3 3 3 3 Amidase RNA_pol_Rpb2_7 PF04560.20 CCL98731.1 - 0.19 12.2 0.1 0.37 11.2 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 7 MFS_1 PF07690.16 CCL98733.1 - 3.7e-14 52.4 50.7 4.9e-14 52.0 35.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCL98734.1 - 1e-10 40.8 10.9 1e-10 40.8 10.9 3.1 2 1 0 2 2 2 1 MFS/sugar transport protein MFS_1 PF07690.16 CCL98734.1 - 8e-07 28.3 16.9 8e-07 28.3 16.9 3.0 3 1 0 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCL98734.1 - 0.011 14.6 4.5 0.032 13.1 4.5 1.7 1 1 0 1 1 1 0 MFS_1 like family YfzA PF14118.6 CCL98734.1 - 0.22 12.0 3.5 34 4.9 0.0 3.8 3 0 0 3 3 3 0 YfzA-like protein ETF_QO PF05187.13 CCL98735.1 - 2.3e-30 104.8 1.3 2.7e-15 56.4 1.2 3.3 1 1 2 3 3 3 3 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 CCL98735.1 - 1.2e-08 35.0 2.0 6.2e-06 26.0 0.9 2.4 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCL98735.1 - 4.7e-07 29.9 0.0 1.5e-06 28.4 0.0 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCL98735.1 - 3.9e-06 26.2 0.8 2.4e-05 23.6 0.7 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CCL98735.1 - 2.4e-05 23.7 0.0 3.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCL98735.1 - 0.00012 21.5 0.2 0.00018 20.9 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CCL98735.1 - 0.00018 21.5 0.1 0.00048 20.1 0.1 1.8 1 1 1 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 CCL98735.1 - 0.00034 19.4 0.2 0.00052 18.8 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CCL98735.1 - 0.00041 19.7 0.2 0.00063 19.1 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCL98735.1 - 0.00049 19.4 0.0 0.0018 17.6 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 CCL98735.1 - 0.0027 16.8 0.0 0.0043 16.2 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 CCL98735.1 - 0.0067 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCL98735.1 - 0.019 13.8 0.1 0.038 12.9 0.2 1.5 1 1 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 CCL98735.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A K_oxygenase PF13434.6 CCL98735.1 - 0.22 10.7 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Fer2 PF00111.27 CCL98736.1 - 1.7e-11 43.9 0.1 2.9e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF3655 PF12379.8 CCL98737.1 - 2.9 8.3 4.8 17 5.8 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3655) Sel1 PF08238.12 CCL98738.1 - 2.9e-19 69.1 17.9 2.5e-06 28.0 0.0 6.6 7 0 0 7 7 7 5 Sel1 repeat TPR_8 PF13181.6 CCL98738.1 - 0.0055 16.8 0.7 0.13 12.6 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCL98738.1 - 0.7 9.8 2.3 1.8 8.5 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCL98738.1 - 4.2 7.7 11.0 0.11 12.7 0.5 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat ADH_N PF08240.12 CCL98739.1 - 4.4e-21 74.8 1.3 7.9e-21 74.0 1.3 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCL98739.1 - 2.4e-06 27.6 0.0 6.3e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase BTB PF00651.31 CCL98740.1 - 3e-08 33.9 0.0 1.7e-07 31.4 0.0 2.3 3 0 0 3 3 3 1 BTB/POZ domain CAP_GLY PF01302.25 CCL98740.1 - 1.9e-07 31.0 0.3 3.7e-06 26.8 0.2 2.4 2 0 0 2 2 2 1 CAP-Gly domain Hexapep PF00132.24 CCL98741.1 - 3.1e-06 26.7 15.2 0.023 14.4 0.5 4.5 3 2 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Ribosomal_L16 PF00252.18 CCL98742.1 - 2.4e-46 157.0 0.0 3e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e HCNGP PF07818.13 CCL98743.1 - 2.5e-26 92.2 0.0 4.3e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 HCNGP-like protein FAD_binding_8 PF08022.12 CCL98745.1 - 3e-14 53.0 0.0 6e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CCL98745.1 - 1.6e-11 44.4 15.7 9.5e-11 41.9 9.6 3.0 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CCL98745.1 - 1.8e-09 37.9 0.0 2.1e-07 31.2 0.0 2.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain HemY_N PF07219.13 CCL98745.1 - 0.039 14.2 0.2 0.039 14.2 0.2 2.2 2 0 0 2 2 2 0 HemY protein N-terminus PAS_9 PF13426.7 CCL98746.1 - 3.2e-31 107.7 0.0 3.4e-16 59.4 0.0 3.6 4 0 0 4 4 4 3 PAS domain PAS PF00989.25 CCL98746.1 - 9.4e-22 77.2 0.0 1e-06 28.7 0.0 4.5 4 0 0 4 4 4 3 PAS fold PAS_3 PF08447.12 CCL98746.1 - 6.8e-19 67.9 0.0 5.5e-11 42.6 0.0 4.4 3 2 0 3 3 3 3 PAS fold PAS_4 PF08448.10 CCL98746.1 - 3.1e-14 53.2 0.0 0.0007 19.8 0.0 4.5 4 0 0 4 4 4 3 PAS fold PAS_11 PF14598.6 CCL98746.1 - 2.3e-07 30.9 0.0 1e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.7 CCL98746.1 - 0.0005 20.0 0.0 0.48 10.5 0.0 2.8 2 0 0 2 2 2 2 PAS domain F_bP_aldolase PF01116.20 CCL98747.1 - 6.9e-90 301.3 0.0 8.2e-90 301.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II LSM PF01423.22 CCL98747.1 - 3e-13 49.3 0.2 7.6e-13 48.0 0.2 1.7 1 0 0 1 1 1 1 LSM domain Torsin PF06309.11 CCL98747.1 - 0.06 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Torsin CPSase_L_D2 PF02786.17 CCL98747.1 - 0.15 11.5 0.5 0.62 9.5 0.3 1.9 1 1 1 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain BCDHK_Adom3 PF10436.9 CCL98748.1 - 2.7e-66 222.4 0.0 3.8e-66 221.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CCL98748.1 - 1.7e-13 51.1 0.0 5.2e-13 49.5 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3719 PF12516.8 CCL98748.1 - 0.022 14.5 0.4 0.2 11.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) 6PGD PF00393.19 CCL98749.1 - 1.2e-88 297.3 0.0 1.4e-88 297.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CCL98749.1 - 1.8e-31 109.5 0.0 3.4e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CCL98749.1 - 1.9e-06 27.9 0.0 3.5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CCL98749.1 - 0.00025 21.1 0.0 0.00049 20.1 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 CCL98749.1 - 0.015 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCL98749.1 - 0.033 14.8 0.1 0.17 12.4 0.0 2.2 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.14 CCL98749.1 - 0.071 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_8 PF13450.6 CCL98749.1 - 0.11 12.8 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCL98749.1 - 0.11 13.1 0.0 0.26 11.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 CCL98750.1 - 1.4e-37 129.6 0.1 1.1e-31 110.2 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98750.1 - 9.2e-18 64.4 0.1 1.6e-16 60.4 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CCL98750.1 - 0.00029 20.3 0.6 0.00047 19.6 0.6 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 CCL98750.1 - 0.069 12.7 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 CCL98750.1 - 0.092 12.7 1.4 5.1 6.9 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Torus PF16131.5 CCL98751.1 - 6.8e-05 23.5 0.2 0.00014 22.5 0.2 1.4 1 0 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 CCL98751.1 - 0.0022 17.7 1.9 0.0037 17.0 1.9 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 CCL98751.1 - 0.23 11.4 0.7 0.4 10.6 0.7 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCL98751.1 - 1.1 9.4 4.2 1.9 8.6 4.2 1.4 1 0 0 1 1 1 0 Zinc finger domain CBF PF03914.17 CCL98752.1 - 8.5e-31 107.3 2.8 8.5e-31 107.3 2.8 2.6 3 1 0 3 3 3 1 CBF/Mak21 family HEAT PF02985.22 CCL98752.1 - 0.01 16.0 0.1 0.05 13.9 0.1 2.3 1 0 0 1 1 1 0 HEAT repeat Cnd1 PF12717.7 CCL98752.1 - 0.086 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 EIF_2_alpha PF07541.12 CCL98753.1 - 2.7e-36 124.2 0.1 1.4e-35 121.9 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 CCL98753.1 - 2.9e-13 49.9 1.0 5.2e-13 49.1 1.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain BUD22 PF09073.10 CCL98753.1 - 0.0082 15.5 0.6 0.0082 15.5 0.6 1.7 2 0 0 2 2 2 1 BUD22 WD40 PF00400.32 CCL98754.1 - 6.4e-50 166.1 18.3 3.9e-08 33.8 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat Tup_N PF08581.10 CCL98754.1 - 1.1e-23 83.4 1.4 2.7e-14 53.2 0.3 2.3 2 0 0 2 2 2 2 Tup N-terminal ANAPC4_WD40 PF12894.7 CCL98754.1 - 1.5e-18 66.9 0.4 5.9e-06 26.5 0.0 5.2 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCL98754.1 - 1.6e-08 34.2 0.0 0.014 14.7 0.0 3.9 4 1 1 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 CCL98754.1 - 1.5e-06 27.4 0.1 0.66 8.9 0.0 4.5 2 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CCL98754.1 - 0.00085 19.3 0.0 0.7 9.7 0.0 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 CCL98754.1 - 0.0036 15.9 0.5 0.46 9.0 0.0 2.6 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 CCL98754.1 - 0.0058 16.0 0.1 11 5.3 0.0 3.6 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 CCL98754.1 - 0.058 13.1 2.2 11 5.7 0.0 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Nup160 PF11715.8 CCL98754.1 - 0.39 9.3 1.1 2.2 6.8 0.0 2.6 2 1 2 4 4 4 0 Nucleoporin Nup120/160 Bud13 PF09736.9 CCL98755.1 - 1.3e-53 181.3 12.1 1.3e-53 181.3 12.1 2.3 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex DUF4407 PF14362.6 CCL98755.1 - 6.4 6.0 9.2 8.6 5.6 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MR_MLE_C PF13378.6 CCL98757.1 - 5.2e-49 166.8 0.3 6.2e-48 163.2 0.3 2.1 1 1 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CCL98757.1 - 9.8e-09 35.4 0.0 2.3e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 CCL98757.1 - 0.028 13.6 0.0 0.044 12.9 0.0 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Sec23_trunk PF04811.15 CCL98759.1 - 4.1e-46 157.5 0.0 6.8e-46 156.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CCL98759.1 - 1.9e-21 75.8 0.1 3.6e-21 74.9 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CCL98759.1 - 1.3e-17 64.3 0.1 2.8e-17 63.2 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CCL98759.1 - 1.1e-14 54.2 3.2 2.5e-14 53.0 3.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CCL98759.1 - 0.0041 17.0 0.0 0.0093 15.8 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat HMMR_N PF15905.5 CCL98760.1 - 0.018 14.6 5.7 0.03 13.8 5.7 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DivIC PF04977.15 CCL98760.1 - 0.16 11.7 9.8 0.43 10.4 3.3 3.0 2 1 1 3 3 3 0 Septum formation initiator FAM76 PF16046.5 CCL98760.1 - 0.22 10.8 2.9 0.35 10.2 2.9 1.2 1 0 0 1 1 1 0 FAM76 protein TPR_MLP1_2 PF07926.12 CCL98760.1 - 0.23 11.5 18.1 0.12 12.4 13.0 2.2 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 CCL98760.1 - 0.26 10.1 10.5 0.43 9.4 10.3 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein TPD52 PF04201.15 CCL98760.1 - 0.37 10.4 3.3 0.41 10.3 1.2 2.0 1 1 0 2 2 2 0 Tumour protein D52 family TACC_C PF05010.14 CCL98760.1 - 0.56 10.0 11.3 0.49 10.1 2.8 2.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Filament PF00038.21 CCL98760.1 - 0.73 9.4 12.0 7.5 6.0 10.7 2.1 1 1 1 2 2 2 0 Intermediate filament protein CENP-F_leu_zip PF10473.9 CCL98760.1 - 0.85 9.6 9.0 0.73 9.9 4.8 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Occludin_ELL PF07303.13 CCL98760.1 - 1.8 9.3 4.5 11 6.8 3.0 2.7 2 1 0 2 2 2 0 Occludin homology domain ADIP PF11559.8 CCL98760.1 - 2.5 8.2 7.6 1.2 9.2 2.0 2.5 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding HalX PF08663.10 CCL98760.1 - 8 6.9 15.9 0.24 11.8 0.7 3.3 1 1 1 2 2 2 0 HalX domain PDEase_I PF00233.19 CCL98761.1 - 9e-48 163.1 0.0 1.2e-39 136.4 0.0 2.5 2 1 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase zf-C2H2 PF00096.26 CCL98762.1 - 0.026 15.0 0.3 8.6 7.0 0.0 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCL98762.1 - 0.033 15.0 0.4 18 6.5 0.0 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger COX16 PF14138.6 CCL98763.1 - 7.9e-30 103.2 0.0 1e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 RPN7 PF10602.9 CCL98764.1 - 3.3e-56 189.7 0.3 4.8e-56 189.2 0.3 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CCL98764.1 - 2.1e-16 60.3 0.1 5.5e-16 59.0 0.0 1.8 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 CCL98764.1 - 0.12 12.5 1.4 0.31 11.3 0.5 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HSCB_C PF07743.13 CCL98764.1 - 0.12 12.9 2.9 0.14 12.7 1.4 1.8 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain TPR_8 PF13181.6 CCL98764.1 - 2.3 8.7 5.8 0.28 11.5 0.5 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN6_N PF18055.1 CCL98765.1 - 3.8e-41 140.1 2.6 3.8e-41 140.1 2.6 2.2 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 CCL98765.1 - 8.4e-19 68.0 0.3 5e-18 65.5 0.2 2.4 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 CCL98765.1 - 1.3e-08 34.4 1.0 3.3e-08 33.1 0.3 2.1 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_7 PF13176.6 CCL98765.1 - 5e-05 23.0 2.1 0.0066 16.4 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CCL98765.1 - 0.0017 17.8 0.6 0.0017 17.8 0.6 2.3 2 1 0 3 3 3 1 MalT-like TPR region DDRGK PF09756.9 CCL98765.1 - 0.12 11.9 0.1 0.12 11.9 0.1 2.0 2 0 0 2 2 2 0 DDRGK domain TPR_2 PF07719.17 CCL98765.1 - 0.19 11.9 5.4 2.6 8.4 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCL98765.1 - 0.98 9.4 3.3 5 7.1 0.1 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCL98765.1 - 1.1 9.8 12.2 50 4.5 0.1 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat BUD22 PF09073.10 CCL98766.1 - 0.8 9.0 3.5 1.2 8.4 3.5 1.2 1 0 0 1 1 1 0 BUD22 zf-C4H2 PF10146.9 CCL98767.1 - 0.00031 21.1 2.5 0.00031 21.1 2.5 1.9 1 1 1 2 2 2 1 Zinc finger-containing protein AT_hook PF02178.19 CCL98767.1 - 0.48 10.5 5.5 1.3 9.1 5.5 1.8 1 0 0 1 1 1 0 AT hook motif Fez1 PF06818.15 CCL98767.1 - 3.4 8.1 10.0 8.8 6.7 10.0 1.6 1 1 0 1 1 1 0 Fez1 Cyclin_N PF00134.23 CCL98768.1 - 2.5e-08 33.7 0.0 3.9e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CCL98768.1 - 1.7e-06 28.5 0.0 3.4e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Cyclin DUF3506 PF12014.8 CCL98769.1 - 2.3e-09 37.4 0.2 4.6e-07 29.9 0.1 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF3506) F-box PF00646.33 CCL98769.1 - 0.019 14.8 1.9 0.027 14.4 0.8 1.8 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 CCL98769.1 - 0.031 14.2 1.6 0.15 12.0 0.8 2.4 2 0 0 2 2 2 0 F-box-like Ral PF11058.8 CCL98769.1 - 0.15 11.6 0.2 0.3 10.7 0.2 1.5 1 0 0 1 1 1 0 Antirestriction protein Ral PhoLip_ATPase_C PF16212.5 CCL98771.1 - 3.2e-72 243.3 27.8 3.2e-72 243.3 27.8 1.8 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCL98771.1 - 1.2e-22 79.4 0.9 3.6e-22 77.8 0.9 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CCL98771.1 - 1.2e-12 48.6 2.1 1.2e-07 32.2 0.9 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCL98771.1 - 1.5e-10 41.0 0.0 5.8e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCL98771.1 - 0.00055 19.8 0.7 0.012 15.3 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCL98771.1 - 0.0089 15.6 0.0 0.0089 15.6 0.0 2.6 2 1 1 3 3 3 1 E1-E2 ATPase IIGP PF05049.13 CCL98772.1 - 4.4e-08 32.6 0.0 9.3e-08 31.5 0.0 1.5 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) HrcA PF01628.21 CCL98772.1 - 0.0024 17.8 0.4 0.0037 17.2 0.4 1.2 1 0 0 1 1 1 1 HrcA protein C terminal domain Aminotran_1_2 PF00155.21 CCL98773.1 - 5.9e-32 111.2 0.0 7.7e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II OKR_DC_1 PF01276.20 CCL98773.1 - 3.1e-05 22.9 0.0 4.4e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 CCL98773.1 - 0.052 12.1 0.0 0.074 11.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme RNase_P_Rpp14 PF01900.19 CCL98774.1 - 9.5e-26 90.0 0.0 1.2e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Oxidored_molyb PF00174.19 CCL98775.1 - 3.4e-51 173.3 0.0 5.3e-51 172.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCL98775.1 - 4.7e-19 68.8 0.6 8.7e-19 67.9 0.6 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Acetyltransf_7 PF13508.7 CCL98776.1 - 5.9e-07 29.8 0.0 8.6e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCL98776.1 - 7.7e-07 29.1 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCL98776.1 - 8.7e-06 26.0 0.0 1.2e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CCL98776.1 - 0.00042 20.2 0.0 0.00068 19.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Glyco_hydro_18 PF00704.28 CCL98777.1 - 1.3e-22 81.0 2.5 1.8e-22 80.5 2.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3439 PF11921.8 CCL98777.1 - 0.055 13.4 9.5 0.15 12.1 9.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FSA_C PF10479.9 CCL98777.1 - 1.5 6.8 6.2 2 6.5 6.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Sporozoite_P67 PF05642.11 CCL98777.1 - 3.3 5.7 7.2 4.4 5.3 7.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4632 PF15451.6 CCL98778.1 - 0.072 13.2 0.2 0.15 12.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) Wtap PF17098.5 CCL98779.1 - 0.00011 22.2 2.9 0.0002 21.3 2.9 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family bZIP_2 PF07716.15 CCL98779.1 - 0.016 15.3 3.4 0.016 15.3 3.4 1.8 2 0 0 2 2 2 0 Basic region leucine zipper CENP-F_leu_zip PF10473.9 CCL98779.1 - 0.076 13.0 0.3 0.19 11.7 0.3 1.6 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4763 PF15960.5 CCL98779.1 - 0.078 12.3 0.1 0.17 11.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) ZapB PF06005.12 CCL98779.1 - 0.099 13.1 0.7 1.7 9.1 0.2 2.4 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 CCL98779.1 - 0.22 11.3 4.9 9.5 6.1 2.8 2.4 2 0 0 2 2 2 0 Septum formation initiator DUF4407 PF14362.6 CCL98779.1 - 0.24 10.7 2.8 0.38 10.1 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CASP_C PF08172.12 CCL98779.1 - 1 8.7 3.9 1.8 7.9 3.9 1.3 1 0 0 1 1 1 0 CASP C terminal APG6_N PF17675.1 CCL98779.1 - 1.2 9.7 3.7 5.7 7.5 0.3 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region CRAL_TRIO PF00650.20 CCL98782.1 - 5.2e-30 104.3 0.0 1.1e-29 103.2 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCL98782.1 - 1e-13 51.2 0.1 2.1e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CCL98782.1 - 0.0059 16.8 0.0 0.0093 16.1 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Cpn60_TCP1 PF00118.24 CCL98783.1 - 2.1e-155 518.1 0.5 2.5e-155 517.8 0.5 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Metallophos PF00149.28 CCL98783.1 - 7.9e-35 121.2 0.7 1.4e-34 120.4 0.7 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCL98783.1 - 0.003 18.0 0.0 0.0085 16.5 0.0 1.8 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain eIF-1a PF01176.19 CCL98784.1 - 1.7e-22 79.0 0.0 2.5e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Ank_2 PF12796.7 CCL98785.1 - 3.9e-05 24.2 0.0 0.0027 18.3 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCL98785.1 - 0.0016 18.7 0.1 1.2 9.6 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCL98785.1 - 0.0017 18.7 0.1 11 6.9 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 CCL98785.1 - 0.0043 17.6 0.0 0.32 11.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DHOR PF06537.11 CCL98785.1 - 0.027 13.1 0.0 0.048 12.3 0.0 1.3 1 0 0 1 1 1 0 Di-haem oxidoreductase, putative peroxidase RHH_5 PF07878.11 CCL98785.1 - 0.058 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 Macro PF01661.21 CCL98786.1 - 7.8e-42 142.0 0.1 1.1e-41 141.5 0.1 1.2 1 0 0 1 1 1 1 Macro domain Sugar_tr PF00083.24 CCL98787.1 - 4e-84 283.1 11.0 5.1e-84 282.7 11.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Pkinase PF00069.25 CCL98788.1 - 5.7e-67 225.9 0.0 1.3e-66 224.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98788.1 - 5.2e-37 127.5 0.0 6.9e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCL98788.1 - 1.3e-09 37.8 0.1 2.5e-09 36.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCL98788.1 - 0.0001 22.3 0.8 0.00017 21.6 0.8 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCL98788.1 - 0.00018 20.4 0.3 0.00039 19.3 0.3 1.4 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CCL98788.1 - 0.00083 18.4 0.7 0.0014 17.7 0.7 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CCL98788.1 - 0.014 15.1 0.3 5.5 6.6 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CCL98788.1 - 0.043 13.2 0.3 0.087 12.2 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PKD_channel PF08016.12 CCL98789.1 - 1e-06 27.7 9.5 4.1e-05 22.5 2.2 2.2 1 1 1 2 2 2 2 Polycystin cation channel Ion_trans PF00520.31 CCL98789.1 - 0.012 14.8 16.2 0.15 11.3 7.3 2.3 1 1 1 2 2 2 0 Ion transport protein WD40 PF00400.32 CCL98790.1 - 0.024 15.5 1.0 16 6.5 0.0 3.7 4 0 0 4 4 4 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98790.1 - 0.2 12.0 0.0 11 6.4 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Glyco_trans_1_3 PF13528.6 CCL98791.1 - 0.2 10.9 0.0 1.5 8.0 0.0 2.0 1 1 0 1 1 1 0 Glycosyl transferase family 1 NPR3 PF03666.13 CCL98792.1 - 1.5e-92 310.8 9.9 2.2e-92 310.3 0.7 2.8 2 1 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 Epimerase PF01370.21 CCL98793.1 - 1.6e-23 83.5 0.0 2e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCL98793.1 - 8.2e-17 61.6 0.0 4.7e-14 52.5 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCL98793.1 - 2.5e-12 47.1 0.0 3.1e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCL98793.1 - 4e-11 42.4 0.0 5.4e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CCL98793.1 - 5.7e-05 22.4 0.0 7.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 CCL98793.1 - 0.00055 20.2 0.6 0.003 17.8 0.6 2.1 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 CCL98793.1 - 0.0009 18.9 0.1 0.0012 18.4 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family DapB_N PF01113.20 CCL98793.1 - 0.002 18.2 0.1 0.0033 17.6 0.1 1.4 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 CCL98793.1 - 0.004 17.2 0.3 0.0069 16.5 0.3 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 CCL98793.1 - 0.017 14.3 0.2 0.24 10.5 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein Orthoreo_P17 PF07272.11 CCL98795.1 - 0.093 12.7 0.2 1.8 8.6 0.0 2.3 2 0 0 2 2 2 0 Orthoreovirus P17 protein WD40 PF00400.32 CCL98796.1 - 0.0053 17.6 0.3 0.12 13.2 0.1 3.4 4 0 0 4 4 4 1 WD domain, G-beta repeat BUD22 PF09073.10 CCL98796.1 - 3.5 6.9 8.6 5.2 6.3 8.6 1.1 1 0 0 1 1 1 0 BUD22 Aa_trans PF01490.18 CCL98797.1 - 5.7e-82 275.6 32.8 8.4e-82 275.1 32.8 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein YpmT PF17431.2 CCL98797.1 - 0.2 11.7 1.3 0.83 9.7 1.3 2.1 1 0 0 1 1 1 0 Uncharacterized YmpT-like Acetyltransf_1 PF00583.25 CCL98798.1 - 2e-07 31.3 0.0 3.2e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCL98798.1 - 2.2e-07 31.2 0.0 3.6e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCL98798.1 - 7.4e-07 29.1 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCL98798.1 - 0.00092 19.3 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CCL98798.1 - 0.0014 18.6 0.0 0.0034 17.3 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CCL98798.1 - 0.033 14.3 0.0 0.062 13.4 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCL98799.1 - 1.2e-08 35.2 0.0 2.7e-08 34.1 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCL98799.1 - 4.2e-08 33.5 0.0 8.6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCL98799.1 - 4.8e-06 26.5 0.0 8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCL98799.1 - 0.00017 21.5 0.0 0.00031 20.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CCL98799.1 - 0.002 18.2 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCL98799.1 - 0.076 13.2 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase AhpC-TSA_2 PF13911.6 CCL98800.1 - 5.6e-16 58.7 0.0 1.1e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 CCL98800.1 - 0.0049 16.8 0.0 0.0094 15.9 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Gtr1_RagA PF04670.12 CCL98801.1 - 1.5e-47 161.9 0.0 2e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 CCL98801.1 - 0.00012 21.5 0.0 0.00021 20.8 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCL98801.1 - 0.0006 19.3 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CCL98801.1 - 0.0023 18.2 0.0 0.0039 17.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 CCL98801.1 - 0.0028 17.7 0.0 0.0087 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCL98801.1 - 0.021 15.2 0.0 0.086 13.2 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CCL98801.1 - 0.034 14.2 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ras PF00071.22 CCL98801.1 - 0.13 11.8 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Ras family SOG2 PF10428.9 CCL98801.1 - 0.29 10.3 10.3 0.45 9.7 10.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 CCL98801.1 - 1.3 8.8 6.5 1.8 8.4 6.5 1.1 1 0 0 1 1 1 0 SPX domain VTC PF09359.10 CCL98802.1 - 6.9e-92 307.7 0.3 3.5e-91 305.4 0.0 2.2 2 1 0 2 2 2 1 VTC domain DUF202 PF02656.15 CCL98802.1 - 2.8e-10 40.5 3.4 6.1e-10 39.4 3.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 CCL98802.1 - 7e-09 36.1 21.9 0.00051 20.1 0.1 4.0 2 1 2 4 4 4 2 SPX domain Herpes_UL25 PF01499.16 CCL98802.1 - 0.022 13.3 0.6 0.034 12.7 0.6 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family Cwf_Cwc_15 PF04889.12 CCL98802.1 - 5.8 6.6 28.9 3.7 7.2 10.8 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Methyltr_RsmB-F PF01189.17 CCL98803.1 - 4.7e-20 72.1 0.6 1.7e-19 70.3 0.0 2.2 2 1 0 2 2 2 1 16S rRNA methyltransferase RsmB/F SF1-HH PF16275.5 CCL98804.1 - 1.8e-38 131.3 1.7 1.8e-38 131.3 1.7 1.9 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 CCL98804.1 - 1.4e-11 43.9 8.9 1.6e-05 24.7 0.3 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 CCL98804.1 - 1.6e-06 28.0 3.8 0.0031 17.4 1.5 2.5 1 1 1 2 2 2 2 Zinc knuckle KH_1 PF00013.29 CCL98804.1 - 6.7e-05 22.6 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_4 PF14392.6 CCL98804.1 - 0.0077 16.0 7.1 0.47 10.2 0.6 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 CCL98804.1 - 0.02 14.7 10.2 0.61 10.0 0.9 3.4 3 0 0 3 3 3 0 Zinc knuckle CCDC-167 PF15188.6 CCL98804.1 - 0.086 13.2 1.2 4.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DnaJ_CXXCXGXG PF00684.19 CCL98804.1 - 0.2 12.0 4.5 0.44 10.9 4.5 1.5 1 0 0 1 1 1 0 DnaJ central domain Prim_Zn_Ribbon PF08273.12 CCL98804.1 - 0.28 11.5 3.6 0.65 10.3 3.6 1.6 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase zf-CCHC_2 PF13696.6 CCL98804.1 - 4.8 7.1 9.8 0.41 10.5 0.7 2.5 2 0 0 2 2 2 0 Zinc knuckle ERCC3_RAD25_C PF16203.5 CCL98805.1 - 4.5e-123 409.3 0.0 9.5e-123 408.2 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 CCL98805.1 - 3.3e-37 127.5 0.0 8.5e-37 126.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCL98805.1 - 2e-16 60.5 0.0 3.6e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 CCL98805.1 - 2.4e-11 42.9 0.0 3.2e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCL98805.1 - 5.6e-11 42.8 0.0 2e-10 41.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ROKNT PF08067.11 CCL98805.1 - 0.096 13.0 0.3 0.29 11.4 0.3 1.9 1 0 0 1 1 1 0 ROKNT (NUC014) domain Sigma70_ner PF04546.13 CCL98805.1 - 1.6 8.5 5.2 0.16 11.8 0.3 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region bZIP_1 PF00170.21 CCL98806.1 - 0.12 12.5 0.3 0.21 11.7 0.3 1.3 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 CCL98806.1 - 0.16 12.1 0.7 0.24 11.5 0.7 1.2 1 0 0 1 1 1 0 Basic region leucine zipper Mto2_bdg PF12808.7 CCL98806.1 - 0.19 12.0 0.1 0.34 11.2 0.1 1.4 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF1687 PF07955.11 CCL98807.1 - 1.7e-23 83.5 0.0 2.3e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) Peptidase_S32 PF05579.13 CCL98808.1 - 0.023 13.9 0.1 0.05 12.8 0.1 1.5 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Trypsin_2 PF13365.6 CCL98808.1 - 0.051 14.5 0.0 11 6.9 0.0 2.5 2 1 0 2 2 2 0 Trypsin-like peptidase domain Peptidase_S7 PF00949.21 CCL98808.1 - 0.14 12.0 0.3 0.77 9.6 0.2 2.1 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease OPT PF03169.15 CCL98811.1 - 2.9e-135 452.3 52.4 7.8e-117 391.4 34.8 2.0 2 0 0 2 2 2 2 OPT oligopeptide transporter protein SUKH_5 PF14567.6 CCL98812.1 - 0.058 13.1 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Diphtheria_C PF02763.14 CCL98812.1 - 0.075 12.7 0.1 0.55 9.9 0.0 1.9 1 1 0 2 2 2 0 Diphtheria toxin, C domain Abhydrolase_1 PF00561.20 CCL98815.1 - 2e-18 67.0 0.1 2.3e-18 66.8 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL98815.1 - 7.2e-12 46.4 0.3 9.1e-12 46.0 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL98815.1 - 5.8e-11 42.1 0.3 1.5e-10 40.8 0.3 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CCL98815.1 - 0.048 13.8 0.1 0.084 13.0 0.1 1.5 1 1 0 1 1 1 0 Thioesterase domain AChE_tetra PF08674.10 CCL98816.1 - 0.054 13.2 0.1 0.22 11.3 0.1 2.1 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain SLBP_RNA_bind PF15247.6 CCL98817.1 - 2.7 8.2 7.2 0.2 11.8 0.7 2.4 3 0 0 3 3 3 0 Histone RNA hairpin-binding protein RNA-binding domain SdpI PF13630.6 CCL98817.1 - 3.6 7.8 5.6 2.1 8.5 2.6 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family SLBP_RNA_bind PF15247.6 CCL98818.1 - 0.015 15.4 0.9 0.015 15.4 0.9 1.9 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain F-box PF00646.33 CCL98819.1 - 0.00032 20.5 0.5 0.00095 19.0 0.5 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCL98819.1 - 0.0014 18.5 4.9 0.0034 17.3 4.9 1.7 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 CCL98820.1 - 2.7e-58 192.6 11.5 3.2e-08 34.1 0.0 9.2 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98820.1 - 7.7e-22 77.4 0.1 0.0029 17.9 0.0 7.1 1 1 7 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCL98820.1 - 2.8e-14 52.8 5.1 0.033 13.1 0.0 6.4 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCL98820.1 - 3e-07 29.5 1.1 0.019 13.6 0.0 3.7 2 1 1 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.12 CCL98820.1 - 1.4e-06 28.0 0.0 1.1 9.2 0.0 5.5 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCL98820.1 - 2.7e-06 26.2 1.3 0.0013 17.4 0.3 3.1 1 1 2 3 3 3 2 Cytochrome D1 heme domain WD40_like PF17005.5 CCL98820.1 - 1.5e-05 24.5 0.0 0.011 15.0 0.0 3.2 2 1 1 3 3 3 1 WD40-like domain Proteasome_A_N PF10584.9 CCL98820.1 - 0.03 14.0 0.8 19 5.0 0.0 4.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Nucleoporin_N PF08801.11 CCL98820.1 - 0.19 10.4 0.0 48 2.5 0.0 3.4 3 1 0 3 3 3 0 Nup133 N terminal like PQQ_3 PF13570.6 CCL98820.1 - 1.5 9.4 7.2 7.8 7.1 0.3 4.4 4 1 1 5 5 5 0 PQQ-like domain RRM_1 PF00076.22 CCL98822.1 - 2.6e-32 110.4 0.0 6.6e-11 41.9 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCL98822.1 - 7.7e-08 32.4 0.0 0.026 14.6 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif RRM_Rrp7 PF17799.1 CCL98822.1 - 0.025 14.4 0.0 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Phosphorylase PF00343.20 CCL98823.1 - 1e-295 982.7 0.0 1.2e-295 982.4 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase HA70_C PF17993.1 CCL98823.1 - 0.055 13.5 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 Haemagglutinin 70 C-terminal domain DUF1708 PF08101.11 CCL98824.1 - 1.2e-17 64.2 0.0 2.1e-16 60.1 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1708) RhoGAP PF00620.27 CCL98824.1 - 0.028 14.3 0.0 0.064 13.1 0.0 1.6 1 1 0 1 1 1 0 RhoGAP domain UQ_con PF00179.26 CCL98825.1 - 2.7e-39 134.0 0.0 4.7e-39 133.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SRP9-21 PF05486.12 CCL98826.1 - 7.1e-12 45.6 1.1 1.3e-10 41.5 1.1 2.2 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Pou PF00157.17 CCL98826.1 - 0.025 14.5 0.2 0.056 13.4 0.2 1.5 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain Mito_carr PF00153.27 CCL98827.1 - 3.9e-49 164.5 1.7 7.1e-18 64.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PaRep2a PF07903.11 CCL98827.1 - 0.049 13.5 0.1 0.077 12.8 0.1 1.3 1 0 0 1 1 1 0 PaRep2a protein Glug PF07581.12 CCL98827.1 - 0.14 12.6 0.6 0.58 10.7 0.2 2.2 2 0 0 2 2 2 0 The GLUG motif Cyt_c_ox_IV PF12270.8 CCL98828.1 - 4.5 7.4 8.8 38 4.4 5.8 3.0 3 0 0 3 3 3 0 Cytochrome c oxidase subunit IV Amino_oxidase PF01593.24 CCL98831.1 - 1.6e-64 218.9 0.1 4.1e-64 217.5 0.1 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCL98831.1 - 2e-09 37.5 0.2 8.6e-09 35.5 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCL98831.1 - 2.3e-06 27.3 0.2 3e-06 26.9 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCL98831.1 - 5.5e-05 22.5 0.1 0.00057 19.2 0.2 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCL98831.1 - 0.00011 21.6 0.7 0.00017 21.0 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CCL98831.1 - 0.00067 18.9 0.7 0.0013 18.0 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCL98831.1 - 0.0009 18.9 2.2 0.0034 17.0 1.8 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CCL98831.1 - 0.0064 15.8 0.2 0.012 15.0 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CCL98831.1 - 0.049 12.7 0.3 0.079 12.0 0.3 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Shikimate_DH PF01488.20 CCL98831.1 - 0.072 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 CCL98831.1 - 0.11 11.7 0.4 0.19 10.9 0.4 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCL98831.1 - 0.14 10.8 0.8 0.23 10.1 0.8 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 CCL98831.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 CCL98831.1 - 0.18 12.4 2.2 0.23 12.0 0.3 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 CCL98832.1 - 9e-31 106.8 3.3 1.3e-30 106.3 3.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL98832.1 - 1.1e-21 77.5 3.7 1.5e-21 77.0 3.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL98832.1 - 1.4e-10 41.4 1.4 4.7e-10 39.7 1.3 1.9 1 1 1 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CCL98832.1 - 0.00065 19.6 2.7 0.0012 18.8 2.4 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Ins134_P3_kin_N PF17927.1 CCL98832.1 - 0.00075 19.9 0.0 0.41 11.1 0.0 3.2 2 2 0 2 2 2 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain Epimerase PF01370.21 CCL98832.1 - 0.00089 18.8 1.5 0.0075 15.8 1.5 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCL98832.1 - 0.0062 17.0 0.3 1.5 9.3 0.1 2.4 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCL98832.1 - 0.0079 16.4 0.6 0.25 11.6 0.2 2.5 2 0 0 2 2 2 1 TrkA-N domain MT PF12777.7 CCL98832.1 - 0.031 13.3 0.1 0.047 12.7 0.1 1.3 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor GidB PF02527.15 CCL98832.1 - 0.095 12.0 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G Thioesterase PF00975.20 CCL98832.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain GARS_N PF02844.15 CCL98832.1 - 0.2 12.5 1.6 0.83 10.5 0.2 2.6 2 1 0 2 2 2 0 Phosphoribosylglycinamide synthetase, N domain adh_short PF00106.25 CCL98833.1 - 5.9e-32 110.7 0.8 8.7e-32 110.2 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL98833.1 - 4.1e-24 85.4 0.8 5.7e-24 85.0 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL98833.1 - 2e-08 34.4 0.0 4.7e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 KR domain TrkA_N PF02254.18 CCL98833.1 - 0.00087 19.5 0.5 0.027 14.7 0.1 2.5 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_10 PF13460.6 CCL98833.1 - 0.018 14.9 0.4 0.03 14.2 0.4 1.6 1 1 0 1 1 1 0 NAD(P)H-binding Semialdhyde_dh PF01118.24 CCL98833.1 - 0.08 13.4 0.1 17 5.9 0.0 2.5 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CCL98833.1 - 0.11 12.0 0.3 1.5 8.2 0.3 2.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 CCL98834.1 - 7.6e-09 35.3 0.0 0.0002 20.8 0.0 3.4 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCL98834.1 - 0.17 11.4 0.0 2.3 7.7 0.0 2.3 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase adh_short_C2 PF13561.6 CCL98835.1 - 1.9e-26 93.1 0.7 2.5e-26 92.7 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCL98835.1 - 7.1e-26 90.9 1.0 1.1e-25 90.3 1.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCL98835.1 - 4.4e-07 30.0 1.5 1.2e-06 28.5 1.5 1.8 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCL98835.1 - 6.5e-05 22.9 1.2 0.00013 21.9 1.2 1.7 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCL98835.1 - 0.037 13.0 0.1 0.055 12.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 CCL98835.1 - 0.047 14.0 0.3 0.1 12.9 0.3 1.6 1 0 0 1 1 1 0 TrkA-N domain ABC_tran PF00005.27 CCL98836.1 - 8.6e-51 172.0 0.0 1.4e-25 90.4 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC2_membrane_3 PF12698.7 CCL98836.1 - 1.2e-19 70.6 39.9 4.6e-11 42.4 23.5 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 CCL98836.1 - 2.8e-18 66.8 0.3 9.7e-05 22.3 0.0 4.3 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCL98836.1 - 6.4e-07 30.1 1.8 0.0087 16.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain DUF4162 PF13732.6 CCL98836.1 - 3.8e-06 27.5 0.0 0.15 12.8 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) SMC_N PF02463.19 CCL98836.1 - 9.7e-06 25.2 2.6 0.79 9.1 0.2 4.2 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_27 PF13514.6 CCL98836.1 - 2.9e-05 23.8 0.2 0.2 11.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CCL98836.1 - 0.00013 21.7 1.5 0.19 11.5 0.4 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCL98836.1 - 0.00054 19.9 0.4 0.86 9.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 CCL98836.1 - 0.0014 18.4 1.7 1.1 8.9 0.0 3.1 2 1 1 3 3 3 2 AAA domain SRP54 PF00448.22 CCL98836.1 - 0.0037 16.9 1.7 1.1 8.9 0.4 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_15 PF13175.6 CCL98836.1 - 0.0041 16.9 0.0 7.5 6.2 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain MukB PF04310.12 CCL98836.1 - 0.0048 16.7 0.3 3 7.6 0.1 2.4 2 0 0 2 2 2 2 MukB N-terminal Zeta_toxin PF06414.12 CCL98836.1 - 0.01 15.2 0.2 2 7.6 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 CCL98836.1 - 0.042 14.1 1.8 9.9 6.4 0.1 3.3 2 2 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CCL98836.1 - 0.081 13.2 0.3 18 5.5 0.3 2.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCL98836.1 - 0.16 12.4 0.1 32 4.8 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 CCL98836.1 - 0.24 11.1 0.4 9.9 5.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CCL98836.1 - 1 9.8 2.5 22 5.5 0.1 3.4 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Dynactin PF12455.8 CCL98838.1 - 6.4e-93 311.1 3.0 6.4e-93 311.1 3.0 3.0 3 2 0 3 3 3 1 Dynein associated protein CAP_GLY PF01302.25 CCL98838.1 - 1.4e-23 82.7 0.9 3.8e-23 81.3 0.7 1.8 2 0 0 2 2 2 1 CAP-Gly domain MHYT PF03707.16 CCL98839.1 - 6.5e-34 115.9 30.4 9e-12 45.0 3.1 4.6 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat HATPase_c PF02518.26 CCL98839.1 - 7.6e-25 87.6 0.0 3.1e-24 85.6 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCL98839.1 - 1.5e-21 76.6 0.0 3.5e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CCL98839.1 - 1.1e-14 54.2 0.0 3.4e-14 52.6 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CCL98839.1 - 6.3e-05 22.8 0.0 0.0003 20.7 0.0 2.1 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CCL98839.1 - 0.098 12.5 0.0 0.4 10.5 0.0 2.0 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BofA PF07441.11 CCL98839.1 - 8.8 6.6 8.7 0.46 10.7 1.6 2.4 2 1 1 3 3 3 0 SigmaK-factor processing regulatory protein BofA iPGM_N PF06415.13 CCL98840.1 - 5.1e-78 261.4 0.1 7.6e-78 260.9 0.1 1.3 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 CCL98840.1 - 1.7e-72 243.8 0.8 2e-72 243.5 0.8 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 CCL98840.1 - 1.5e-05 24.6 0.1 0.00017 21.1 0.1 2.2 1 1 0 1 1 1 1 Sulfatase PglZ PF08665.12 CCL98840.1 - 0.14 12.3 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 PglZ domain Tetraspanin PF00335.20 CCL98841.1 - 2.5e-08 33.9 10.3 3.3e-08 33.5 10.3 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF983 PF06170.12 CCL98841.1 - 9.3 6.7 8.8 31 5.1 2.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF983) POB3_N PF17292.2 CCL98842.1 - 2.4e-35 120.9 0.5 1e-31 109.2 0.2 2.7 2 1 0 2 2 2 2 POB3-like N-terminal PH domain SSrecog PF03531.14 CCL98842.1 - 4.8e-24 84.0 0.0 1.7e-23 82.3 0.0 2.0 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 CCL98842.1 - 4.6e-21 75.0 0.2 3e-20 72.4 0.0 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like CH PF00307.31 CCL98843.1 - 4.2e-40 136.3 0.0 2.8e-25 88.6 0.0 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 CCL98843.1 - 5.5e-18 64.8 0.0 2.1e-17 62.9 0.0 2.1 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 CCL98843.1 - 7.8e-12 44.9 0.3 2.1e-09 37.1 0.1 2.6 2 1 0 2 2 2 1 CAMSAP CH domain Spectrin PF00435.21 CCL98843.1 - 0.00014 22.3 2.6 0.077 13.5 0.1 2.9 3 0 0 3 3 2 2 Spectrin repeat EF-hand_6 PF13405.6 CCL98843.1 - 0.001 18.8 0.1 0.007 16.2 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_14 PF17959.1 CCL98843.1 - 0.0024 18.2 0.9 2.7 8.4 0.0 3.6 3 2 0 3 3 3 1 EF-hand domain Med9 PF07544.13 CCL98843.1 - 0.0044 17.1 3.5 0.59 10.3 0.1 4.5 4 1 1 5 5 5 1 RNA polymerase II transcription mediator complex subunit 9 EF-hand_1 PF00036.32 CCL98843.1 - 0.01 15.3 0.1 0.041 13.4 0.0 2.1 2 0 0 2 2 2 0 EF hand COG2 PF06148.11 CCL98843.1 - 0.015 15.4 1.0 0.045 13.8 0.2 2.3 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.12 CCL98843.1 - 0.03 14.4 2.9 0.069 13.2 0.1 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CALCOCO1 PF07888.11 CCL98843.1 - 0.092 11.6 3.5 0.2 10.5 3.5 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Seryl_tRNA_N PF02403.22 CCL98843.1 - 0.17 12.1 2.1 0.35 11.1 0.8 2.1 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.9 CCL98843.1 - 0.26 11.3 1.8 0.64 10.0 1.8 1.7 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MscS_porin PF12795.7 CCL98843.1 - 0.38 10.3 5.7 0.9 9.0 5.7 1.6 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TetR_C_24 PF17932.1 CCL98843.1 - 0.39 11.0 2.8 1.4 9.2 0.3 3.1 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain SF-assemblin PF06705.11 CCL98843.1 - 0.55 9.5 6.7 0.18 11.1 3.7 1.7 2 0 0 2 2 2 0 SF-assemblin/beta giardin Spc7 PF08317.11 CCL98843.1 - 0.61 8.9 9.8 0.023 13.6 2.4 2.2 2 1 0 2 2 2 0 Spc7 kinetochore protein FAM184 PF15665.5 CCL98843.1 - 1.2 8.9 7.1 1.1 9.0 1.2 2.5 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B Cofilin_ADF PF00241.20 CCL98844.1 - 1.1e-40 138.2 0.6 1.3e-40 138.0 0.6 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SF3A3 PF16837.5 CCL98844.1 - 0.049 14.1 0.1 0.081 13.4 0.1 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 MmgE_PrpD PF03972.14 CCL98845.1 - 1.5e-121 406.0 0.0 1.8e-121 405.8 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family DLH PF01738.18 CCL98846.1 - 1.1e-22 80.7 0.0 1.6e-22 80.1 0.0 1.3 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 CCL98846.1 - 0.05 13.5 0.0 0.16 11.9 0.0 1.7 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Amino_oxidase PF01593.24 CCL98847.1 - 2.4e-38 132.6 0.0 2.7e-38 132.4 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCL98847.1 - 3.6e-07 30.3 0.0 8e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCL98847.1 - 0.017 13.8 0.1 0.056 12.1 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 CCL98847.1 - 0.13 11.5 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Porin_3 PF01459.22 CCL98848.1 - 3.5e-75 252.9 0.9 4e-75 252.8 0.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin Rhodanese PF00581.20 CCL98849.1 - 1.2e-08 35.4 0.0 1.5e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DUF3767 PF12597.8 CCL98850.1 - 9.1e-27 92.8 0.0 1.2e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) MIP PF00230.20 CCL98851.1 - 1.4e-49 168.9 5.6 4.7e-49 167.1 5.6 1.7 1 1 0 1 1 1 1 Major intrinsic protein Ysc84 PF04366.12 CCL98852.1 - 6e-46 155.3 0.1 1.2e-45 154.4 0.1 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator Phosphodiest PF01663.22 CCL98853.1 - 6.3e-76 256.3 0.7 8.8e-76 255.8 0.7 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Dynactin_p62 PF05502.13 CCL98854.1 - 9e-40 136.9 0.3 1.5e-26 93.3 0.6 2.1 1 1 0 2 2 2 2 Dynactin p62 family Gemini_mov PF01708.16 CCL98855.1 - 1.5 8.6 3.0 0.77 9.6 0.1 2.0 2 0 0 2 2 2 0 Geminivirus putative movement protein Glyco_hydro_15 PF00723.21 CCL98856.1 - 6.4e-96 321.9 0.1 7.5e-96 321.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 CCL98856.1 - 1.2e-25 89.2 0.6 3.1e-25 87.9 0.6 1.8 1 0 0 1 1 1 1 Starch binding domain AMPK1_CBM PF16561.5 CCL98856.1 - 0.0034 17.6 0.0 0.0077 16.4 0.0 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase GCFC PF07842.12 CCL98857.1 - 0.028 14.0 0.0 0.095 12.3 0.0 1.9 1 1 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein Trypan_PARP PF05887.11 CCL98857.1 - 1.1 9.3 5.3 0.51 10.3 2.0 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Rad60-SLD PF11976.8 CCL98858.1 - 7.3e-09 35.3 0.0 0.0003 20.6 0.0 3.2 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like Trehalose_PPase PF02358.16 CCL98858.1 - 0.021 14.0 0.0 0.78 8.8 0.0 2.4 1 1 1 2 2 2 0 Trehalose-phosphatase LRR_6 PF13516.6 CCL98859.1 - 4.7e-16 57.4 0.9 0.31 11.2 0.0 8.0 8 1 0 8 8 8 6 Leucine Rich repeat LRR_4 PF12799.7 CCL98859.1 - 1.6e-05 25.1 7.4 0.12 12.8 1.9 5.7 4 2 3 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCL98859.1 - 0.0011 19.2 1.4 41 5.3 0.0 5.6 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.6 CCL98859.1 - 0.013 15.2 9.1 3.6 7.4 1.8 5.2 5 2 0 5 5 5 0 Leucine rich repeat Phosphodiest PF01663.22 CCL98860.1 - 1.6e-11 44.4 0.2 3.2e-11 43.4 0.2 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CCL98860.1 - 0.0014 18.1 0.0 0.072 12.5 0.0 2.3 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 CCL98860.1 - 0.0016 17.9 0.0 0.0044 16.4 0.0 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily Fungal_trans PF04082.18 CCL98861.1 - 3.1e-09 36.3 0.0 5.4e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CBFD_NFYB_HMF PF00808.23 CCL98862.1 - 0.00011 22.4 0.0 0.067 13.5 0.2 2.5 1 1 1 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Gti1_Pac2 PF09729.9 CCL98862.1 - 1.1 9.3 5.4 0.55 10.3 3.1 1.7 2 0 0 2 2 2 0 Gti1/Pac2 family PPP4R2 PF09184.11 CCL98862.1 - 1.2 8.7 15.2 1.7 8.1 15.2 1.2 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 CCL98862.1 - 7.7 5.7 11.6 11 5.2 11.6 1.2 1 0 0 1 1 1 0 NOA36 protein F-box-like PF12937.7 CCL98863.1 - 1.3e-08 34.6 0.4 3.8e-08 33.1 0.1 2.0 2 0 0 2 2 2 1 F-box-like Rhodanese PF00581.20 CCL98864.1 - 4.5e-07 30.4 0.0 6.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Glyco_hydro_42M PF08532.10 CCL98864.1 - 0.22 11.0 0.0 0.42 10.1 0.0 1.4 1 0 0 1 1 1 0 Beta-galactosidase trimerisation domain ABC_tran PF00005.27 CCL98867.1 - 5.9e-45 153.1 0.1 7.7e-27 94.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCL98867.1 - 7.1e-45 153.8 28.7 3.6e-25 89.1 7.0 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 CCL98867.1 - 5e-11 42.5 3.9 0.013 15.0 0.3 4.4 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCL98867.1 - 1.6e-07 32.1 0.5 0.00054 20.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 CCL98867.1 - 1.8e-07 31.2 3.9 0.0092 15.8 0.3 4.4 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCL98867.1 - 3.9e-06 26.5 0.1 0.11 12.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCL98867.1 - 8.5e-06 26.3 0.2 0.26 11.6 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CCL98867.1 - 4.8e-05 23.0 1.2 0.45 10.1 0.0 3.5 4 0 0 4 4 4 2 AAA domain MMR_HSR1 PF01926.23 CCL98867.1 - 0.00011 22.2 0.1 0.17 12.0 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SSE PF00437.20 CCL98867.1 - 0.00012 21.2 0.0 0.023 13.8 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 CCL98867.1 - 0.00036 20.5 0.1 0.33 10.8 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 CCL98867.1 - 0.0012 19.0 0.3 0.071 13.2 0.1 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain IstB_IS21 PF01695.17 CCL98867.1 - 0.0013 18.5 2.5 1.1 9.0 0.0 3.9 5 0 0 5 5 3 1 IstB-like ATP binding protein AAA_22 PF13401.6 CCL98867.1 - 0.0016 18.8 1.4 1 9.7 0.0 3.4 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 CCL98867.1 - 0.0018 17.7 0.0 0.68 9.2 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_5 PF07728.14 CCL98867.1 - 0.0032 17.5 0.3 9 6.3 0.0 4.3 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) Pox_A32 PF04665.12 CCL98867.1 - 0.0066 15.9 0.1 3.2 7.1 0.0 2.4 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_15 PF13175.6 CCL98867.1 - 0.0088 15.8 1.2 0.2 11.3 0.0 2.7 3 0 0 3 3 2 1 AAA ATPase domain ATPase_2 PF01637.18 CCL98867.1 - 0.0089 16.0 0.1 0.38 10.6 0.0 2.9 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea Adeno_IVa2 PF02456.15 CCL98867.1 - 0.012 14.4 0.1 0.19 10.5 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein DEAD PF00270.29 CCL98867.1 - 0.015 15.1 0.2 7.9 6.2 0.2 3.1 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_7 PF12775.7 CCL98867.1 - 0.028 13.9 0.2 4.6 6.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 CCL98867.1 - 0.034 14.7 0.1 14 6.3 0.0 3.2 4 0 0 4 4 2 0 AAA domain RTP1_C2 PF10304.9 CCL98867.1 - 0.037 13.7 0.0 0.092 12.5 0.0 1.6 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 2 Dynamin_N PF00350.23 CCL98867.1 - 0.045 13.8 0.5 3.2 7.8 0.0 2.7 2 0 0 2 2 2 0 Dynamin family ResIII PF04851.15 CCL98867.1 - 0.05 13.6 0.0 2.4 8.1 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CCL98867.1 - 0.059 13.1 0.1 3 7.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 CCL98867.1 - 0.063 12.9 1.8 0.39 10.3 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PhoH PF02562.16 CCL98867.1 - 0.074 12.5 0.0 6.3 6.2 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Roc PF08477.13 CCL98867.1 - 0.1 12.8 0.1 14 5.9 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 CCL98867.1 - 0.18 11.5 0.5 6.9 6.4 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Phage_Gp23 PF10669.9 CCL98867.1 - 0.39 11.1 1.8 2.9 8.2 0.1 2.6 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) NACHT PF05729.12 CCL98867.1 - 0.43 10.5 2.3 3.8 7.4 0.0 2.8 3 0 0 3 3 2 0 NACHT domain AAA PF00004.29 CCL98867.1 - 4.8 7.6 5.0 3.4 8.1 0.1 3.3 3 2 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) DUF455 PF04305.14 CCL98868.1 - 2.2e-87 292.7 0.0 3.4e-87 292.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF455) RicinB_lectin_2 PF14200.6 CCL98868.1 - 4.6e-08 33.7 0.2 0.00044 20.9 0.0 3.1 2 1 3 5 5 5 4 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 CCL98868.1 - 0.0039 17.4 0.0 0.7 10.2 0.0 2.4 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain Rieske PF00355.26 CCL98868.1 - 0.028 14.4 0.0 0.064 13.2 0.0 1.6 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain Fungal_trans PF04082.18 CCL98870.1 - 2.2e-12 46.6 0.4 4.4e-12 45.6 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pkinase PF00069.25 CCL98872.1 - 7.5e-65 218.9 0.1 7.1e-64 215.7 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98872.1 - 3.8e-36 124.7 0.0 1e-35 123.3 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 CCL98872.1 - 3.8e-11 42.6 0.0 6.5e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.14 CCL98872.1 - 8e-06 25.4 0.2 1.3e-05 24.6 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCL98872.1 - 2.3e-05 23.9 0.0 5.1e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCL98872.1 - 2.3e-05 24.4 0.0 0.00036 20.5 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCL98872.1 - 0.00022 20.3 0.1 0.00037 19.5 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain WaaY PF06176.11 CCL98872.1 - 0.023 14.3 0.3 0.036 13.7 0.3 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Rad60-SLD PF11976.8 CCL98873.1 - 1.8e-12 46.9 0.0 2.2e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCL98873.1 - 4.7e-09 35.9 0.0 5.5e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family TUG-UBL1 PF11470.8 CCL98873.1 - 0.0027 17.9 0.0 0.0036 17.5 0.0 1.2 1 0 0 1 1 1 1 TUG ubiquitin-like domain RBD PF02196.15 CCL98873.1 - 0.14 12.2 0.0 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 Raf-like Ras-binding domain ATG22 PF11700.8 CCL98874.1 - 5.8e-124 414.3 9.1 7.3e-124 414.0 9.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 CCL98874.1 - 1.7e-10 40.4 47.6 1.5e-06 27.4 26.8 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily Mito_carr PF00153.27 CCL98875.1 - 1.1e-21 76.5 6.7 1.2e-08 34.7 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein TFIIS_M PF07500.14 CCL98876.1 - 1.9e-32 112.0 0.1 1.9e-32 112.0 0.1 2.2 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 CCL98876.1 - 1.5e-11 43.9 4.8 2.6e-11 43.2 4.8 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 CCL98876.1 - 6.1e-10 39.0 2.7 1.3e-09 37.9 2.7 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain WD40 PF00400.32 CCL98878.1 - 1.7e-41 139.4 19.6 4.1e-08 33.8 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL98878.1 - 0.00019 21.6 0.9 2.1 8.7 0.1 4.7 1 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCL98878.1 - 0.0024 16.6 1.2 0.36 9.4 0.1 3.5 1 1 3 4 4 4 1 Nucleoporin Nup120/160 Peptidase_M48_N PF16491.5 CCL98879.1 - 5.5e-62 208.9 5.9 5.5e-62 208.9 5.9 1.7 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CCL98879.1 - 3.1e-37 128.3 0.0 5.4e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 DRY_EERY PF09750.9 CCL98879.1 - 0.036 14.3 1.6 0.1 12.9 1.6 1.7 1 1 0 1 1 1 0 Alternative splicing regulator Peptidase_M56 PF05569.11 CCL98879.1 - 0.11 11.7 0.2 0.18 11.0 0.2 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 SprT-like PF10263.9 CCL98879.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 SprT-like family Piwi PF02171.17 CCL98880.1 - 2.2e-73 247.2 0.0 4.6e-73 246.1 0.0 1.5 2 0 0 2 2 2 1 Piwi domain ArgoN PF16486.5 CCL98880.1 - 1.3e-14 55.0 0.1 5.4e-13 49.7 0.1 2.5 2 0 0 2 2 2 1 N-terminal domain of argonaute PAZ PF02170.22 CCL98880.1 - 8.9e-12 45.0 0.0 1.9e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 CCL98880.1 - 3e-11 42.8 0.1 8.4e-11 41.4 0.1 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 CCL98880.1 - 6.3e-10 39.2 0.0 1.8e-09 37.8 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 CCL98880.1 - 1.2e-05 25.5 0.0 2.7e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Mid domain of argonaute p450 PF00067.22 CCL98881.1 - 1.9e-51 175.3 0.0 2.5e-51 174.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4791 PF16039.5 CCL98881.1 - 0.075 12.6 0.0 12 5.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4791) DUF3206 PF11472.8 CCL98881.1 - 0.079 13.0 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) Piwi PF02171.17 CCL98882.1 - 9.4e-71 238.5 0.0 1.3e-70 238.1 0.0 1.1 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CCL98882.1 - 1.9e-18 67.4 0.3 7.6e-18 65.5 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CCL98882.1 - 3.7e-15 55.3 1.4 9e-15 54.1 0.5 2.2 3 0 0 3 3 3 1 Argonaute linker 1 domain PAZ PF02170.22 CCL98882.1 - 2.8e-12 46.6 0.0 5.1e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 CCL98882.1 - 1.8e-10 41.0 0.0 5.5e-10 39.4 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 CCL98882.1 - 2.3e-05 24.6 0.1 5.1e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Mid domain of argonaute NifU PF01106.17 CCL98882.1 - 0.043 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 NifU-like domain DUF2856 PF11043.8 CCL98882.1 - 0.15 12.2 0.0 0.48 10.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2856) Pyr_redox_2 PF07992.14 CCL98883.1 - 3.3e-12 46.2 0.9 2.1e-08 33.8 0.2 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCL98883.1 - 9.4e-12 44.1 0.0 5.5e-05 21.8 0.0 3.1 3 1 0 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCL98883.1 - 1.6e-08 34.7 4.9 2.3e-08 34.1 0.1 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCL98883.1 - 5.3e-08 32.8 0.4 5.3e-08 32.8 0.4 2.7 4 0 0 4 4 4 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCL98883.1 - 1.6e-06 27.6 0.3 0.21 10.8 0.0 4.2 4 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCL98883.1 - 7.8e-06 25.5 4.6 2.7e-05 23.7 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCL98883.1 - 8.4e-06 26.3 2.7 0.045 14.3 0.3 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCL98883.1 - 9.7e-06 24.9 2.6 0.00071 18.8 0.3 2.5 3 0 0 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 CCL98883.1 - 2.2e-05 23.4 0.7 0.0036 16.1 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein K_oxygenase PF13434.6 CCL98883.1 - 2.3e-05 23.7 0.2 0.013 14.6 0.0 3.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 CCL98883.1 - 2.6e-05 23.6 4.3 0.02 14.2 0.3 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CCL98883.1 - 3.4e-05 23.1 0.3 3.4e-05 23.1 0.3 2.6 3 0 0 3 3 3 1 FAD binding domain Amino_oxidase PF01593.24 CCL98883.1 - 0.00055 19.4 1.2 0.0045 16.3 1.2 2.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_7 PF13241.6 CCL98883.1 - 0.00088 19.7 0.0 0.14 12.6 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 CCL98883.1 - 0.0023 17.9 0.3 0.0023 17.9 0.3 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 CCL98883.1 - 0.0024 17.9 3.6 0.13 12.3 0.1 3.5 4 0 0 4 4 4 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 CCL98883.1 - 0.025 14.6 0.1 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 CCL98883.1 - 0.035 13.4 3.1 0.24 10.6 0.3 2.2 2 0 0 2 2 2 0 FAD binding domain zf-C2H2 PF00096.26 CCL98885.1 - 0.013 16.0 0.3 0.069 13.6 0.3 2.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCL98885.1 - 0.021 15.6 4.8 0.058 14.2 0.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCL98885.1 - 0.68 9.7 6.1 0.72 9.7 0.8 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 CCL98885.1 - 1.2 9.5 8.1 0.064 13.6 2.1 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding TPR_2 PF07719.17 CCL98887.1 - 1e-36 122.1 10.7 4.3e-05 23.3 0.0 10.6 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.28 CCL98887.1 - 6.1e-36 120.8 12.1 1e-05 25.1 0.0 10.4 10 1 0 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 CCL98887.1 - 7.2e-22 77.8 4.6 1.4e-05 25.7 0.0 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCL98887.1 - 1.6e-20 71.5 13.5 4.6e-05 23.3 0.0 9.8 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_17 PF13431.6 CCL98887.1 - 9.1e-20 69.6 1.2 0.0069 16.7 0.0 8.1 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCL98887.1 - 5.4e-18 64.4 8.8 1.8e-07 30.7 0.0 7.1 6 2 1 7 7 6 3 TPR repeat TPR_14 PF13428.6 CCL98887.1 - 8.7e-18 63.5 7.2 4.3e-06 27.1 0.0 8.0 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCL98887.1 - 2.6e-16 59.7 12.6 4.5e-06 26.9 0.0 7.6 5 1 3 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCL98887.1 - 1.4e-15 57.6 14.3 0.00044 20.7 0.0 5.7 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCL98887.1 - 1e-11 43.9 3.6 0.042 13.9 0.0 7.6 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCL98887.1 - 1.4e-10 41.2 6.2 0.0058 16.8 0.0 5.3 5 2 3 8 8 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CCL98887.1 - 9.7e-10 38.5 3.9 0.012 15.8 0.0 4.5 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 CCL98887.1 - 1.3e-09 37.9 2.8 2.8e-07 30.2 0.1 3.7 2 2 1 3 3 3 1 MalT-like TPR region TPR_6 PF13174.6 CCL98887.1 - 7.6e-06 26.2 9.9 0.96 10.2 0.0 6.8 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 CCL98887.1 - 0.00028 20.2 3.9 0.033 13.4 0.0 3.7 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCL98887.1 - 0.00087 19.1 13.9 2.1 8.3 0.0 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat DUF627 PF04781.12 CCL98887.1 - 0.0063 16.5 0.2 0.16 12.0 0.0 3.0 3 0 0 3 3 2 1 Protein of unknown function (DUF627) TPR_21 PF09976.9 CCL98887.1 - 0.0077 16.0 12.1 0.95 9.1 0.0 5.1 5 1 1 6 6 6 2 Tetratricopeptide repeat-like domain NARP1 PF12569.8 CCL98887.1 - 0.01 14.8 0.1 0.01 14.8 0.1 3.4 3 1 0 4 4 4 0 NMDA receptor-regulated protein 1 PknG_TPR PF16918.5 CCL98887.1 - 0.018 13.8 3.3 4.3 6.0 1.2 3.0 3 0 0 3 3 3 0 Protein kinase G tetratricopeptide repeat PPR PF01535.20 CCL98887.1 - 0.019 15.2 0.0 1.1 9.7 0.0 3.0 2 0 0 2 2 2 0 PPR repeat DUF3856 PF12968.7 CCL98887.1 - 0.059 13.4 0.7 4.6 7.3 0.0 3.6 3 1 1 4 4 3 0 Domain of Unknown Function (DUF3856) TPR_20 PF14561.6 CCL98887.1 - 0.066 13.5 12.1 14 6.1 0.0 5.8 5 1 1 6 6 6 0 Tetratricopeptide repeat Prolamin_like PF05617.11 CCL98887.1 - 0.072 13.3 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 Prolamin-like Fis1_TPR_C PF14853.6 CCL98887.1 - 0.086 12.9 0.7 5.8 7.1 0.0 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat PPR_2 PF13041.6 CCL98887.1 - 0.12 12.6 0.0 1.6 9.0 0.0 2.7 2 0 0 2 2 2 0 PPR repeat family Phage_term_smal PF05944.12 CCL98887.1 - 0.14 12.1 1.9 0.38 10.7 0.0 2.7 4 0 0 4 4 3 0 Phage small terminase subunit RPN7 PF10602.9 CCL98887.1 - 1.2 8.8 6.6 1.9 8.2 0.0 3.6 3 2 0 3 3 3 0 26S proteasome subunit RPN7 Diphthamide_syn PF01866.17 CCL98888.1 - 3.5e-59 200.7 0.0 1.2e-34 120.1 0.0 2.7 1 1 1 2 2 2 2 Putative diphthamide synthesis protein DUF3500 PF12006.8 CCL98890.1 - 0.0043 16.6 0.0 0.0043 16.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) ABC_sub_bind PF04392.12 CCL98890.1 - 0.0089 15.3 0.2 0.01 15.1 0.2 1.0 1 0 0 1 1 1 1 ABC transporter substrate binding protein SSP160 PF06933.11 CCL98891.1 - 2.5 6.2 11.5 3.9 5.6 11.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 CCL98891.1 - 2.7 8.0 17.3 0.13 12.2 11.7 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF3439 PF11921.8 CCL98891.1 - 4.2 7.3 11.7 0.25 11.3 6.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Sugar_tr PF00083.24 CCL98892.1 - 1.4e-130 436.2 13.5 1.6e-130 436.0 13.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCL98892.1 - 1.7e-21 76.6 35.6 1.3e-15 57.3 13.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Polysacc_deac_2 PF04748.13 CCL98893.1 - 0.014 14.6 0.0 0.015 14.5 0.0 1.0 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase FIVAR PF07554.13 CCL98893.1 - 0.14 12.9 1.1 0.26 12.1 0.2 1.8 2 0 0 2 2 2 0 FIVAR domain V1R PF03402.14 CCL98895.1 - 0.12 11.9 0.4 2 7.9 0.5 2.1 2 0 0 2 2 2 0 Vomeronasal organ pheromone receptor family, V1R Saf_2TM PF18303.1 CCL98896.1 - 0.087 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain TMEM154 PF15102.6 CCL98897.1 - 0.0088 16.0 0.4 0.0088 16.0 0.4 1.5 2 0 0 2 2 2 1 TMEM154 protein family Velvet PF11754.8 CCL98897.1 - 0.015 15.3 2.1 0.089 12.7 1.2 2.1 2 0 0 2 2 2 0 Velvet factor Stevor PF17410.2 CCL98897.1 - 0.021 14.4 0.1 0.032 13.8 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame RDD PF06271.12 CCL98897.1 - 0.041 14.1 0.0 0.056 13.7 0.0 1.3 1 0 0 1 1 1 0 RDD family FixQ PF05545.11 CCL98897.1 - 0.045 13.7 1.0 0.089 12.8 1.0 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Macoilin PF09726.9 CCL98897.1 - 0.094 11.3 4.3 0.13 10.9 4.3 1.1 1 0 0 1 1 1 0 Macoilin family stn_TNFRSF12A PF12191.8 CCL98897.1 - 0.12 12.6 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Apt1 PF10351.9 CCL98897.1 - 0.16 10.8 2.8 0.18 10.6 2.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain GDP_Man_Dehyd PF16363.5 CCL98898.1 - 2.2e-40 139.1 0.0 3.1e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCL98898.1 - 2.4e-39 135.2 0.0 3.1e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCL98898.1 - 1.9e-10 40.3 0.0 3.9e-10 39.3 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CCL98898.1 - 6.6e-10 38.4 0.0 2.1e-09 36.8 0.0 1.8 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CCL98898.1 - 2.3e-09 36.8 0.0 1.4e-08 34.2 0.0 2.2 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CCL98898.1 - 1.4e-06 28.3 0.0 2.6e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 CCL98898.1 - 1.1e-05 24.7 0.0 2.8e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein DapB_N PF01113.20 CCL98898.1 - 0.025 14.7 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 CCL98898.1 - 0.093 12.2 0.1 0.74 9.2 0.1 2.1 1 1 0 1 1 1 0 short chain dehydrogenase efThoc1 PF11957.8 CCL98899.1 - 1.9e-85 287.4 0.0 1.6e-79 267.9 0.0 2.1 2 0 0 2 2 2 2 THO complex subunit 1 transcription elongation factor SMC_ScpA PF02616.14 CCL98899.1 - 0.053 13.4 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 Segregation and condensation protein ScpA Tuberin PF03542.16 CCL98899.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Tuberin Rotamase PF00639.21 CCL98900.1 - 3.3e-22 79.2 0.0 4.5e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CCL98900.1 - 1.1e-19 71.1 0.0 1.4e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 CCL98900.1 - 9.2e-06 25.7 0.4 9.2e-06 25.7 0.4 1.9 2 1 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 CCL98900.1 - 0.00085 20.1 0.0 0.0013 19.6 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Fungal_trans PF04082.18 CCL98901.1 - 2.7e-18 66.0 0.2 4.4e-18 65.3 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2235 PF09994.9 CCL98902.1 - 3e-89 299.2 0.0 3.9e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) p450 PF00067.22 CCL98903.1 - 1.7e-45 155.7 0.0 2e-45 155.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCL98904.1 - 1.3e-44 152.7 0.0 1.6e-44 152.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF726 PF05277.12 CCL98905.1 - 9.5e-116 386.5 0.8 1.3e-115 386.0 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) SRP14 PF02290.15 CCL98905.1 - 2.6e-21 75.8 0.0 6.2e-21 74.6 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle 14kD protein DUF2951 PF11166.8 CCL98905.1 - 0.055 13.7 0.6 0.33 11.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) TP_methylase PF00590.20 CCL98906.1 - 2.1e-36 125.9 0.6 4.5e-36 124.8 0.2 1.7 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 CCL98906.1 - 3.5e-12 46.7 0.1 1e-11 45.2 0.0 1.9 2 0 0 2 2 2 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 CCL98906.1 - 7.2e-08 32.0 0.2 1.7e-07 30.8 0.2 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 CCL98906.1 - 3e-06 26.6 0.1 6.9e-06 25.4 0.1 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central SMC_N PF02463.19 CCL98907.1 - 2.6e-75 252.6 0.0 5.3e-75 251.6 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCL98907.1 - 5.6e-23 81.5 0.0 2.1e-22 79.6 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 CCL98907.1 - 1.8e-14 54.7 0.6 1.8e-14 54.7 0.6 7.0 3 2 2 5 5 5 1 AAA domain AAA_21 PF13304.6 CCL98907.1 - 2.9e-10 40.4 0.2 5.9e-06 26.3 0.0 4.5 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CCL98907.1 - 6.2e-07 29.4 8.9 6.2e-07 29.4 8.9 4.6 2 2 2 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 CCL98907.1 - 6.5e-06 25.8 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Fib_alpha PF08702.10 CCL98907.1 - 0.0029 17.8 3.2 0.0029 17.8 3.2 6.4 5 1 2 7 7 7 2 Fibrinogen alpha/beta chain family ABC_tran PF00005.27 CCL98907.1 - 0.3 11.6 0.0 0.3 11.6 0.0 5.5 3 2 0 3 3 3 0 ABC transporter DUF3573 PF12097.8 CCL98907.1 - 4.8 5.9 10.9 9 5.0 3.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) Pkinase PF00069.25 CCL98908.1 - 1.9e-38 132.4 0.0 5e-33 114.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCL98908.1 - 3.1e-17 62.7 0.0 4.8e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCL98908.1 - 0.0014 17.6 0.0 0.0021 17.0 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCL98908.1 - 0.0033 16.8 0.0 0.0056 16.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCL98908.1 - 0.06 12.1 0.0 0.085 11.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CCL98908.1 - 0.097 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FBPase PF00316.20 CCL98909.1 - 2.8e-74 248.7 0.4 3.5e-74 248.4 0.4 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CCL98909.1 - 0.0014 18.2 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family Nramp PF01566.18 CCL98911.1 - 7.9e-90 301.4 19.6 3.3e-49 167.8 2.8 2.9 3 0 0 3 3 3 2 Natural resistance-associated macrophage protein CD34_antigen PF06365.12 CCL98911.1 - 0.21 11.1 0.0 0.21 11.1 0.0 2.0 3 0 0 3 3 3 0 CD34/Podocalyxin family Utp14 PF04615.13 CCL98912.1 - 8.1e-203 676.1 51.2 8.1e-203 676.1 51.2 2.1 1 1 1 2 2 2 1 Utp14 protein ubiquitin PF00240.23 CCL98913.1 - 1.4e-34 117.7 0.5 1.7e-34 117.4 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 CCL98913.1 - 1.2e-27 95.6 5.2 1.8e-27 95.0 5.2 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CCL98913.1 - 2.7e-16 59.2 0.6 4.1e-16 58.6 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCL98913.1 - 1.9e-05 25.0 0.1 7e-05 23.2 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCL98913.1 - 0.0044 16.9 0.0 0.0058 16.5 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CCL98913.1 - 0.0051 17.1 0.0 0.0076 16.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCL98913.1 - 0.0069 16.5 0.1 0.012 15.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CCL98913.1 - 0.012 15.6 1.1 3.7 7.7 0.2 2.1 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 CCL98913.1 - 0.029 14.9 0.0 0.04 14.5 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 CCL98913.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Adap_comp_sub PF00928.21 CCL98914.1 - 3.1e-17 62.8 0.0 4.8e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family MBOAT_2 PF13813.6 CCL98914.1 - 2.5e-09 37.3 7.8 2.7e-09 37.2 5.9 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Clat_adaptor_s PF01217.20 CCL98914.1 - 3.2e-05 23.9 0.0 5.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Phytoreo_Pns PF05451.11 CCL98914.1 - 0.071 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns10/11 DUF4337 PF14235.6 CCL98914.1 - 4 7.5 4.5 7.2 6.7 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) p450 PF00067.22 CCL98915.1 - 7.2e-48 163.5 0.0 9e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TPX2 PF06886.11 CCL98916.1 - 3.1e-07 30.5 20.1 3.1e-07 30.5 20.1 2.1 2 0 0 2 2 2 1 Targeting protein for Xklp2 (TPX2) UPF0564 PF10595.9 CCL98916.1 - 0.00018 20.7 0.1 0.0003 20.0 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 2-oxoacid_dh PF00198.23 CCL98917.1 - 1e-47 162.6 0.0 1.5e-46 158.7 0.0 2.0 1 1 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCL98917.1 - 5.6e-18 64.5 0.3 1.2e-17 63.5 0.3 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCL98917.1 - 2.8e-13 50.0 0.3 8.8e-13 48.4 0.1 2.1 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CCL98917.1 - 0.0012 18.7 0.1 0.0027 17.5 0.1 1.6 1 0 0 1 1 1 1 Biotin-lipoyl like DHC_N1 PF08385.12 CCL98918.1 - 5.8e-129 431.3 7.8 4.5e-128 428.3 3.5 2.5 2 0 0 2 2 2 2 Dynein heavy chain, N-terminal region 1 DUF21 PF01595.20 CCL98919.1 - 1.3e-06 28.3 0.0 0.017 14.8 0.0 2.4 2 0 0 2 2 2 2 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CCL98919.1 - 0.00036 20.9 0.1 0.15 12.5 0.0 3.3 3 0 0 3 3 3 1 CBS domain tRNA_U5-meth_tr PF05958.11 CCL98920.1 - 1e-15 57.6 0.0 2.6e-15 56.3 0.0 1.6 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 CCL98920.1 - 1.4e-06 28.0 0.0 2.6e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CCL98920.1 - 2.9e-06 27.9 0.0 1e-05 26.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCL98920.1 - 0.00031 21.3 0.0 0.0028 18.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCL98920.1 - 0.0012 18.6 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CCL98920.1 - 0.0013 18.4 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 CCL98920.1 - 0.038 13.5 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 CCL98920.1 - 0.066 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 CCL98920.1 - 0.15 11.4 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PS_Dcarbxylase PF02666.15 CCL98921.1 - 8.9e-77 257.2 0.0 6.7e-58 195.5 0.0 2.2 1 1 1 2 2 2 2 Phosphatidylserine decarboxylase Rtf2 PF04641.12 CCL98922.1 - 5.4e-74 248.9 0.8 6.3e-74 248.6 0.8 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 CCL98922.1 - 0.0031 17.6 0.0 0.0064 16.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 CCL98922.1 - 0.0073 16.1 0.2 0.039 13.8 0.0 2.2 2 1 1 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit zinc_ribbon_15 PF17032.5 CCL98922.1 - 0.11 13.3 0.1 0.4 11.4 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon family DUF5302 PF17227.2 CCL98922.1 - 0.31 12.1 3.8 0.26 12.3 1.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5302) Med21 PF11221.8 CCL98923.1 - 1.7e-22 80.2 8.0 1.2e-18 67.8 8.0 2.1 1 1 0 1 1 1 1 Subunit 21 of Mediator complex SseC PF04888.12 CCL98923.1 - 0.11 12.1 1.9 8.1 5.9 0.4 2.1 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Paramyx_P_V_C PF03210.13 CCL98923.1 - 0.17 11.6 1.8 0.77 9.5 0.2 2.2 1 1 1 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal Cep57_MT_bd PF06657.13 CCL98923.1 - 0.26 11.8 4.6 2 8.9 0.3 2.4 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF3772 PF12607.8 CCL98923.1 - 0.64 9.8 2.7 2.7 7.8 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3772) Cullin PF00888.22 CCL98924.1 - 2.7e-135 452.4 6.5 2.7e-135 452.4 6.5 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 CCL98924.1 - 1e-23 83.1 0.8 2.8e-23 81.7 0.8 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF515 PF04415.12 CCL98924.1 - 7.4 4.8 8.3 0.097 11.0 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF515) DUF35_N PF12172.8 CCL98925.1 - 4.2 7.3 10.1 1.2 9.1 6.3 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) G-alpha PF00503.20 CCL98926.1 - 2.6e-103 345.9 0.1 3.1e-103 345.6 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCL98926.1 - 6.7e-13 48.5 3.2 7.1e-08 32.1 0.9 2.8 2 2 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCL98926.1 - 0.0035 17.4 0.2 0.57 10.3 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCL98926.1 - 0.0061 16.1 0.1 1.4 8.4 0.1 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 CCL98926.1 - 0.0097 16.1 0.5 1.9 8.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.12 CCL98926.1 - 0.046 13.0 0.3 4.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Gtr1_RagA PF04670.12 CCL98926.1 - 0.053 12.9 5.5 0.66 9.3 0.6 2.5 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCL98926.1 - 0.071 13.0 0.3 3.8 7.4 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase SNF2_N PF00176.23 CCL98926.1 - 0.079 11.7 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_15 PF13175.6 CCL98926.1 - 0.11 12.2 0.1 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 CCL98926.1 - 0.13 12.0 0.1 0.26 11.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain adh_short_C2 PF13561.6 CCL98927.1 - 3.6e-53 180.5 6.2 4e-51 173.8 6.2 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCL98927.1 - 3.2e-48 163.8 4.2 3.8e-48 163.5 4.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCL98927.1 - 5.6e-16 59.0 0.6 7.7e-16 58.5 0.6 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCL98927.1 - 0.015 15.2 0.3 0.027 14.3 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3752 PF12572.8 CCL98928.1 - 3.2e-31 108.9 10.0 3.2e-31 108.9 10.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) tRNA-synt_1g PF09334.11 CCL98929.1 - 1.6e-137 458.4 0.0 2e-137 458.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.20 CCL98929.1 - 2.3e-06 27.7 6.2 2.3e-06 27.7 6.2 1.8 2 0 0 2 2 2 1 WHEP-TRS domain tRNA-synt_1 PF00133.22 CCL98929.1 - 4e-06 25.4 0.0 0.00015 20.2 0.0 2.6 2 1 1 3 3 3 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCL98929.1 - 0.00011 22.1 0.2 0.00034 20.6 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA zinc-ribbons_6 PF07191.12 CCL98929.1 - 0.047 13.7 1.2 0.1 12.6 1.2 1.5 1 0 0 1 1 1 0 zinc-ribbons C1_1 PF00130.22 CCL98929.1 - 0.27 11.2 1.9 0.75 9.7 1.9 1.7 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 CCL98929.1 - 5.1 7.2 7.0 12 6.0 6.4 1.8 1 1 1 2 2 2 0 Double zinc ribbon A_deaminase PF00962.22 CCL98930.1 - 9.1e-16 58.1 0.3 1.4e-12 47.6 0.3 2.9 1 1 0 1 1 1 1 Adenosine/AMP deaminase Chs7 PF12271.8 CCL98931.1 - 1.5e-115 385.6 22.0 1.7e-115 385.4 22.0 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Cyclin PF08613.11 CCL98932.1 - 5.3e-16 59.4 0.3 2.6e-15 57.1 0.0 2.3 3 0 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 CCL98932.1 - 3.9e-08 33.1 0.0 6.3e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain SPO22 PF08631.10 CCL98934.1 - 1.4e-10 41.1 16.8 1.7e-09 37.6 0.8 4.2 3 1 0 4 4 4 2 Meiosis protein SPO22/ZIP4 like Mad3_BUB1_I PF08311.12 CCL98934.1 - 0.083 12.9 0.2 2.9 7.9 0.0 3.1 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 SRP_TPR_like PF17004.5 CCL98934.1 - 0.097 12.7 0.0 27 4.8 0.0 2.9 2 0 0 2 2 2 0 Putative TPR-like repeat DUF1804 PF08822.11 CCL98934.1 - 0.19 11.7 2.3 22 5.0 0.8 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1804) ANAPC3 PF12895.7 CCL98934.1 - 0.33 11.2 5.4 0.34 11.2 2.9 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 CCL98934.1 - 1.1 9.6 6.9 44 4.5 1.1 5.0 5 1 1 6 6 6 0 Tetratricopeptide repeat FMO-like PF00743.19 CCL98935.1 - 8.1e-36 123.5 0.0 4e-25 88.2 0.0 2.6 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCL98935.1 - 5.5e-06 25.9 0.9 0.0028 17.0 0.0 3.3 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCL98935.1 - 2.3e-05 23.7 0.1 0.0054 15.9 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCL98935.1 - 0.00026 20.3 0.0 0.0024 17.1 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCL98935.1 - 0.00049 20.1 1.9 0.0047 16.9 0.0 3.0 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCL98935.1 - 0.0081 16.4 0.5 0.058 13.6 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Malic_M PF03949.15 CCL98935.1 - 0.049 12.9 0.0 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain DAO PF01266.24 CCL98935.1 - 6.3 6.3 8.4 2 7.9 0.7 3.1 3 1 1 4 4 4 0 FAD dependent oxidoreductase tRNA-synt_1c PF00749.21 CCL98936.1 - 4.4e-86 288.6 0.0 6e-86 288.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain zf-UBR PF02207.20 CCL98937.1 - 1.7e-17 63.3 16.1 1.7e-17 63.3 16.1 2.0 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 CCL98937.1 - 2.2e-10 40.2 0.0 5.3e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS His_Phos_1 PF00300.22 CCL98937.1 - 0.66 9.6 2.2 0.71 9.5 0.0 2.0 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) zf-CXXC PF02008.20 CCL98937.1 - 1.7 8.7 8.3 0.33 11.0 4.0 2.0 2 0 0 2 2 2 0 CXXC zinc finger domain TRAPP PF04051.16 CCL98938.1 - 1.8e-33 115.3 0.0 2e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component ANAPC4_WD40 PF12894.7 CCL98939.1 - 8.3e-08 32.4 0.0 0.045 14.0 0.0 4.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCL98939.1 - 0.00013 22.7 0.8 20 6.2 0.0 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat CDC45 PF02724.14 CCL98939.1 - 7.5 4.7 12.5 11 4.2 12.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_25 PF01755.17 CCL98941.1 - 1.4e-06 28.3 0.6 0.49 10.2 0.0 4.1 4 1 0 4 4 4 2 Glycosyltransferase family 25 (LPS biosynthesis protein) AAA_33 PF13671.6 CCL98942.1 - 0.0019 18.4 0.1 0.11 12.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 CCL98942.1 - 0.01 14.8 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 CCL98942.1 - 0.012 14.9 0.1 0.028 13.7 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.6 CCL98942.1 - 0.02 15.4 0.0 0.097 13.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CCL98942.1 - 0.064 13.7 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CCL98942.1 - 0.077 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCL98942.1 - 0.086 13.2 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain CPT PF07931.12 CCL98942.1 - 0.15 11.9 0.0 0.51 10.2 0.0 1.8 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein zf-C2H2 PF00096.26 CCL98944.1 - 2.4e-09 37.1 8.9 0.00051 20.4 0.2 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCL98944.1 - 1.8e-06 28.1 7.9 4.9e-05 23.6 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCL98944.1 - 0.00036 21.1 9.4 0.039 14.8 0.4 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CCL98944.1 - 0.019 14.8 1.1 0.019 14.8 1.1 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 CCL98944.1 - 0.027 14.5 4.7 0.21 11.6 0.4 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 CCL98944.1 - 0.18 12.5 1.5 5 7.8 0.2 2.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-H2C2_5 PF13909.6 CCL98944.1 - 0.22 11.3 0.2 0.22 11.3 0.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain E1-E2_ATPase PF00122.20 CCL98946.1 - 6.9e-53 178.8 5.1 3.1e-52 176.7 1.9 2.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCL98946.1 - 9.6e-44 149.3 8.8 9.6e-44 149.3 8.8 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 CCL98946.1 - 4.2e-21 74.4 0.1 2.4e-19 68.8 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 CCL98946.1 - 4.7e-20 72.8 0.8 4.9e-19 69.5 0.8 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCL98946.1 - 1.6e-17 63.3 0.0 3e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCL98946.1 - 5.3e-07 29.6 0.6 2.7e-06 27.3 0.5 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCL98946.1 - 5.6e-05 23.6 0.1 0.00017 22.1 0.1 1.9 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1772 PF08592.11 CCL98946.1 - 0.074 13.4 0.0 0.074 13.4 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF1772) zf-C3HC4_3 PF13920.6 CCL98947.1 - 0.0031 17.3 8.5 0.0056 16.5 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn-C2H2_12 PF18112.1 CCL98947.1 - 0.15 12.6 0.6 0.36 11.3 0.6 1.6 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain CBP4 PF07960.11 CCL98948.1 - 3.1e-08 33.5 0.0 3.4e-08 33.4 0.0 1.0 1 0 0 1 1 1 1 CBP4 DUF4748 PF15932.5 CCL98948.1 - 0.23 11.3 1.0 0.57 10.0 1.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4748) DPBB_1 PF03330.18 CCL98949.1 - 0.0018 18.5 0.0 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 Lytic transglycolase DPBB_1 PF03330.18 CCL98950.1 - 2.6e-06 27.6 0.0 4.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 CCL98950.1 - 0.01 15.7 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Barwin family SOG2 PF10428.9 CCL98950.1 - 2.3 7.3 27.8 3 6.9 27.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein RCC1 PF00415.18 CCL98952.1 - 6.3e-18 65.1 4.8 0.011 16.3 0.0 9.1 8 2 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCL98952.1 - 1.9e-06 27.5 15.2 0.065 13.1 0.1 6.7 7 1 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat RRM_1 PF00076.22 CCL98953.1 - 5.6e-26 90.2 0.0 1.4e-12 47.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUF PF00806.19 CCL98953.1 - 2.1e-21 74.3 0.0 3.3e-05 23.3 0.0 5.6 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat RRM_occluded PF16842.5 CCL98953.1 - 1.2e-05 25.1 0.0 0.053 13.4 0.0 2.6 2 0 0 2 2 2 2 Occluded RNA-recognition motif Nab6_mRNP_bdg PF10567.9 CCL98953.1 - 0.045 13.2 0.0 0.37 10.2 0.0 2.1 2 0 0 2 2 2 0 RNA-recognition motif Linker_histone PF00538.19 CCL98955.1 - 1.8e-22 79.5 0.1 1.8e-22 79.5 0.1 2.3 2 0 0 2 2 2 1 linker histone H1 and H5 family AT_hook PF02178.19 CCL98955.1 - 0.012 15.3 0.7 0.1 12.5 0.7 2.8 1 0 0 1 1 1 0 AT hook motif Glyco_transf_90 PF05686.12 CCL98955.1 - 0.034 13.0 0.0 0.057 12.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 90 HTH_9 PF08221.11 CCL98956.1 - 1.5e-17 63.4 1.2 9.1e-14 51.3 0.3 3.9 4 0 0 4 4 4 2 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.13 CCL98956.1 - 1.2e-13 51.4 2.7 1.5e-11 44.6 1.1 2.7 2 1 0 3 3 3 2 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 CCL98956.1 - 1.4e-10 41.0 7.2 3.3e-07 30.1 0.2 5.5 5 1 1 6 6 6 2 TFIIE alpha subunit TMEM135_C_rich PF15982.5 CCL98957.1 - 3.2e-05 24.5 0.5 0.00023 21.8 0.0 2.3 3 0 0 3 3 3 1 N-terminal cysteine-rich region of Transmembrane protein 135 WD40 PF00400.32 CCL98958.1 - 0.0036 18.1 15.3 0.88 10.6 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat Frtz PF11768.8 CCL98958.1 - 0.1 10.9 0.0 0.14 10.4 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Adaptin_N PF01602.20 CCL98959.1 - 2.8e-125 418.9 5.7 2.8e-125 418.9 5.7 1.5 2 0 0 2 2 2 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 CCL98959.1 - 5.3e-38 129.7 0.0 1.3e-37 128.4 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 CCL98959.1 - 4.5e-17 62.4 0.1 9e-17 61.4 0.1 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 CCL98959.1 - 1.3e-06 28.6 0.9 0.00037 20.6 0.0 3.0 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CCL98959.1 - 0.015 15.5 0.4 2.7 8.5 0.1 3.6 3 0 0 3 3 3 0 HEAT repeat Mic1 PF07035.12 CCL98959.1 - 0.21 11.3 1.7 21 4.8 0.1 3.5 3 0 0 3 3 3 0 Colon cancer-associated protein Mic1-like RasGAP PF00616.19 CCL98960.1 - 2.4e-25 89.5 0.0 2.6e-17 63.3 0.0 2.2 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 CCL98960.1 - 1e-09 38.6 0.0 2e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain ELO PF01151.18 CCL98961.1 - 2.8e-62 210.5 19.8 3.5e-62 210.2 19.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family VPS13_mid_rpt PF16910.5 CCL98963.1 - 1.8e-98 328.7 7.5 8.8e-97 323.1 1.6 3.6 2 1 1 3 3 3 2 Repeating coiled region of VPS13 VPS13 PF16908.5 CCL98963.1 - 4.3e-81 272.2 2.8 1.1e-75 254.5 0.0 3.7 3 0 0 3 3 3 3 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 CCL98963.1 - 2.1e-69 232.9 3.9 5.6e-65 218.5 0.1 2.7 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 CCL98963.1 - 2.8e-65 220.4 0.0 1.3e-60 205.1 0.0 3.0 2 1 0 2 2 2 2 SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N PF12624.7 CCL98963.1 - 1.3e-30 105.9 0.0 7.3e-30 103.5 0.0 2.4 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 CCL98963.1 - 6.7e-09 36.0 0.0 3.6e-08 33.6 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3040 PF11239.8 CCL98963.1 - 0.2 12.0 0.7 0.61 10.4 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) SR-25 PF10500.9 CCL98963.1 - 0.45 10.1 6.1 0.96 9.0 6.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DENN PF02141.21 CCL98964.1 - 4.3e-20 72.5 0.0 8.8e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain DUF4795 PF16043.5 CCL98964.1 - 0.059 13.0 9.7 0.011 15.3 5.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Med28 PF11594.8 CCL98964.1 - 0.27 11.3 1.4 0.54 10.3 1.4 1.4 1 0 0 1 1 1 0 Mediator complex subunit 28 SLATT_1 PF18181.1 CCL98964.1 - 0.71 9.8 3.0 1.7 8.6 3.0 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 IFT57 PF10498.9 CCL98964.1 - 0.72 8.8 9.7 0.25 10.2 6.2 1.8 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 BRE1 PF08647.11 CCL98964.1 - 1.1 9.4 13.0 3.5 7.8 13.0 1.8 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Filament PF00038.21 CCL98964.1 - 3.3 7.2 20.0 0.18 11.4 13.3 2.1 2 1 1 3 3 3 0 Intermediate filament protein FAM184 PF15665.5 CCL98964.1 - 4.1 7.1 15.7 0.23 11.2 10.1 1.7 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B TMPIT PF07851.13 CCL98964.1 - 4.3 6.5 7.0 8 5.6 7.0 1.3 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 CCL98964.1 - 4.5 8.0 13.6 9.4 6.9 0.3 3.1 2 1 1 3 3 3 0 Initiation control protein YabA Golgin_A5 PF09787.9 CCL98964.1 - 9.8 5.5 17.5 0.34 10.3 10.4 1.9 2 0 0 2 2 2 0 Golgin subfamily A member 5 SUKH-3 PF14433.6 CCL98965.1 - 0.093 13.2 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 SUKH-3 immunity protein Gemini_AC4_5_2 PF08464.10 CCL98965.1 - 0.14 12.1 0.3 0.28 11.1 0.3 1.4 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region IF4E PF01652.18 CCL98966.1 - 5.6e-50 169.2 0.0 8.2e-50 168.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Pil1 PF13805.6 CCL98967.1 - 1e-40 140.0 5.3 1.4e-40 139.5 5.3 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 Arg_decarbox_C PF17944.1 CCL98967.1 - 0.12 13.0 0.9 5.8 7.6 0.0 2.9 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension YabA PF06156.13 CCL98967.1 - 1.5 9.5 5.3 9.1 7.0 2.7 2.4 2 0 0 2 2 2 0 Initiation control protein YabA AdoMet_MTase PF07757.13 CCL98968.1 - 2.9e-21 75.9 0.0 1.5e-19 70.4 0.0 2.6 1 1 1 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_23 PF13489.6 CCL98968.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 CCL98968.1 - 0.21 11.6 0.2 0.43 10.6 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain F-box-like PF12937.7 CCL98969.1 - 0.0078 16.1 0.2 0.0078 16.1 0.2 2.2 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 CCL98969.1 - 0.012 16.0 1.2 5.4 7.6 0.0 4.7 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) tRNA_bind_3 PF17176.4 CCL98969.1 - 0.17 12.2 1.9 1.5 9.2 0.1 2.7 3 0 0 3 3 3 0 tRNA-binding domain F-box-like PF12937.7 CCL98970.1 - 0.045 13.6 4.7 0.68 9.9 4.7 2.5 1 1 0 1 1 1 0 F-box-like PAXNEB PF05625.11 CCL98971.1 - 8.2e-57 193.0 0.0 1e-56 192.7 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein IL6Ra-bind PF09240.10 CCL98971.1 - 0.057 13.8 0.1 8.6 6.9 0.0 2.3 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding DUF371 PF04027.13 CCL98971.1 - 0.11 12.5 0.1 0.29 11.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF371) Peptidase_S26 PF10502.9 CCL98972.1 - 1.3e-05 25.0 0.0 0.0056 16.5 0.0 2.6 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 CCL98972.1 - 2e-05 24.5 0.0 4.7e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase S24-like TPR_1 PF00515.28 CCL98973.1 - 3.8e-06 26.5 0.3 0.035 14.0 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCL98973.1 - 0.00025 20.9 0.5 0.95 9.7 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCL98973.1 - 0.0092 16.3 0.1 1.7 9.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCL98973.1 - 0.048 13.7 0.2 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCL98973.1 - 0.085 13.1 0.0 0.32 11.3 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCL98973.1 - 0.12 13.0 0.7 4.4 8.0 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Snf7 PF03357.21 CCL98974.1 - 5.2e-40 136.9 20.3 2.7e-39 134.5 20.5 1.7 2 0 0 2 2 2 1 Snf7 Resolvase PF00239.21 CCL98974.1 - 0.14 12.3 12.5 0.1 12.7 5.2 2.7 2 1 1 3 3 3 0 Resolvase, N terminal domain Ribosomal_L10 PF00466.20 CCL98974.1 - 0.28 11.3 4.0 0.33 11.1 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L10 YlqD PF11068.8 CCL98974.1 - 0.36 11.2 16.2 1.2 9.5 8.0 2.2 1 1 1 2 2 2 0 YlqD protein KfrA_N PF11740.8 CCL98974.1 - 0.58 10.8 10.2 0.6 10.8 2.3 3.0 2 1 1 3 3 3 0 Plasmid replication region DNA-binding N-term DUF4407 PF14362.6 CCL98974.1 - 0.65 9.3 7.2 0.92 8.8 7.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 CCL98974.1 - 4 7.5 14.3 1.5 8.9 10.0 2.3 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.9 CCL98974.1 - 8.8 7.1 12.2 21 5.9 3.8 2.8 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) adh_short PF00106.25 CCL98975.1 - 2.6e-31 108.6 0.0 3.4e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL98975.1 - 3.5e-17 62.7 0.0 4.4e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL98975.1 - 2e-05 24.6 0.0 0.00013 21.9 0.0 1.9 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCL98975.1 - 0.00016 22.0 0.0 0.00027 21.2 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 CCL98975.1 - 0.0059 16.0 0.3 0.0073 15.7 0.3 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Shikimate_DH PF01488.20 CCL98975.1 - 0.07 13.2 0.1 0.22 11.6 0.1 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 CCL98975.1 - 0.097 12.1 0.0 0.39 10.1 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CCL98975.1 - 0.14 11.5 0.1 0.91 8.8 0.0 2.1 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-oxoacid_dh PF00198.23 CCL98976.1 - 3.1e-81 272.3 0.0 4e-81 271.9 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCL98976.1 - 3.7e-19 68.3 1.3 1.1e-18 66.8 1.3 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCL98976.1 - 2.5e-14 53.3 0.2 6.1e-14 52.1 0.2 1.7 1 0 0 1 1 1 1 e3 binding domain EXOSC1 PF10447.9 CCL98977.1 - 2.3e-17 63.6 2.1 4.1e-12 46.7 0.4 2.2 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 Sugar_tr PF00083.24 CCL98978.1 - 3.5e-36 125.1 30.7 2.9e-33 115.4 30.7 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCL98978.1 - 6.4e-15 54.9 40.7 8.4e-08 31.5 19.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 CCL98978.1 - 0.0011 17.3 6.1 0.12 10.5 0.4 2.9 2 1 1 3 3 3 2 BT1 family DUF3854 PF12965.7 CCL98978.1 - 0.074 13.0 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) NUDE_C PF04880.13 CCL98979.1 - 1.7e-06 28.7 24.0 1.7e-06 28.7 24.0 5.9 2 2 2 6 6 6 1 NUDE protein, C-terminal conserved region PRKG1_interact PF15898.5 CCL98979.1 - 0.0066 17.3 7.3 0.0066 17.3 7.3 3.6 2 1 2 4 4 4 3 cGMP-dependent protein kinase interacting domain Fez1 PF06818.15 CCL98979.1 - 0.13 12.7 22.1 0.21 12.0 7.7 2.4 1 1 1 2 2 2 0 Fez1 Spc7 PF08317.11 CCL98979.1 - 2.3 7.0 25.3 0.086 11.7 10.2 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Tup_N PF08581.10 CCL98979.1 - 3.3 8.1 15.6 0.47 10.8 5.9 3.4 1 1 2 3 3 3 0 Tup N-terminal TPR_MLP1_2 PF07926.12 CCL98979.1 - 5.4 7.1 31.1 2.2 8.4 8.3 3.4 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein TPD52 PF04201.15 CCL98979.1 - 6.1 6.4 13.3 1.9 8.1 1.1 2.5 2 0 0 2 2 2 0 Tumour protein D52 family GAS PF13851.6 CCL98979.1 - 7.2 5.9 27.4 0.64 9.3 13.8 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Es2 PF09751.9 CCL98980.1 - 1.3e-87 295.4 9.2 1.8e-87 294.9 9.2 1.2 1 0 0 1 1 1 1 Nuclear protein Es2 Nefa_Nip30_N PF10187.9 CCL98981.1 - 1.8e-31 108.6 9.7 1.8e-31 108.6 9.7 2.1 3 0 0 3 3 3 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF572 PF04502.13 CCL98981.1 - 0.11 12.1 13.3 0.16 11.6 13.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Totivirus_coat PF05518.11 CCL98981.1 - 2.2 6.2 7.6 2.9 5.9 7.6 1.1 1 0 0 1 1 1 0 Totivirus coat protein F-box-like PF12937.7 CCL98983.1 - 0.007 16.2 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like SOG2 PF10428.9 CCL98983.1 - 0.03 13.5 0.8 0.044 13.0 0.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein LXG PF04740.12 CCL98983.1 - 0.039 13.7 0.1 0.094 12.4 0.0 1.6 2 0 0 2 2 2 0 LXG domain of WXG superfamily PRANC PF09372.10 CCL98983.1 - 0.16 12.3 0.0 0.6 10.5 0.0 1.9 2 0 0 2 2 2 0 PRANC domain AMP-binding PF00501.28 CCL98984.1 - 2e-23 82.7 0.0 8.1e-21 74.1 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme Rad51 PF08423.11 CCL98985.1 - 8.8e-08 31.7 0.0 0.00034 20.0 0.0 2.3 2 0 0 2 2 2 2 Rad51 TSC22 PF01166.18 CCL98986.1 - 0.058 13.7 14.2 0.7 10.2 1.6 4.4 4 1 1 5 5 5 0 TSC-22/dip/bun family HAP1_N PF04849.13 CCL98986.1 - 0.59 9.3 38.2 1.9 7.6 0.0 3.1 2 1 0 2 2 2 0 HAP1 N-terminal conserved region HAUS-augmin3 PF14932.6 CCL98986.1 - 0.64 9.6 33.9 0.6 9.6 7.6 3.9 2 1 1 4 4 4 0 HAUS augmin-like complex subunit 3 Pox_A_type_inc PF04508.12 CCL98986.1 - 1.5 8.8 5.3 4.2 7.4 0.8 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Golgin_A5 PF09787.9 CCL98986.1 - 2.4 7.6 31.2 8.2 5.8 31.3 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 YabA PF06156.13 CCL98986.1 - 6.6 7.4 24.0 2.1 9.1 0.3 4.6 3 1 1 4 4 4 0 Initiation control protein YabA AMP-binding PF00501.28 CCL98987.1 - 2e-24 86.0 0.1 2.5e-23 82.4 0.1 2.1 1 1 0 1 1 1 1 AMP-binding enzyme SLX9 PF15341.6 CCL98987.1 - 3.1e-21 76.1 5.8 5.9e-21 75.2 5.8 1.5 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 EamA PF00892.20 CCL98987.1 - 3.9e-05 23.8 32.4 0.026 14.7 14.5 3.3 3 0 0 3 3 3 3 EamA-like transporter family DUF3955 PF13127.6 CCL98987.1 - 0.0016 18.2 2.2 0.0016 18.2 2.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3955) GH3 PF03321.13 CCL98987.1 - 0.04 12.8 0.0 0.074 11.9 0.0 1.3 1 0 0 1 1 1 0 GH3 auxin-responsive promoter PPR_2 PF13041.6 CCL98988.1 - 1.1e-27 96.0 0.0 2.7e-08 33.9 0.0 6.5 6 2 2 8 8 8 5 PPR repeat family PPR PF01535.20 CCL98988.1 - 2.5e-20 71.2 0.9 1.7e-06 27.9 0.0 6.9 7 0 0 7 7 7 4 PPR repeat PPR_3 PF13812.6 CCL98988.1 - 8e-19 67.5 0.7 0.0029 17.7 0.0 6.9 5 2 2 7 7 7 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCL98988.1 - 2.3e-16 59.2 0.0 6.1e-06 25.8 0.0 5.6 6 0 0 6 6 6 4 PPR repeat PPR_long PF17177.4 CCL98988.1 - 5.3e-10 39.0 1.7 0.0055 16.1 0.1 3.9 3 1 0 3 3 3 3 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 CCL98988.1 - 1.1e-05 25.8 3.3 4.5 7.9 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat MRP-S27 PF10037.9 CCL98988.1 - 0.055 12.3 0.0 7.6 5.3 0.0 2.7 2 1 1 3 3 3 0 Mitochondrial 28S ribosomal protein S27 Hap4_Hap_bind PF10297.9 CCL98989.1 - 6.2e-09 35.7 3.6 1.2e-08 34.7 3.6 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 CCL98989.1 - 1.7e-05 24.8 15.6 3.5e-05 23.8 14.5 2.1 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 CCL98989.1 - 0.013 15.6 18.3 0.087 12.9 5.3 2.5 2 0 0 2 2 2 0 Basic region leucine zipper YabA PF06156.13 CCL98989.1 - 0.025 15.2 1.3 0.064 13.9 1.3 1.7 1 0 0 1 1 1 0 Initiation control protein YabA HAUS-augmin3 PF14932.6 CCL98989.1 - 0.029 14.0 6.1 0.047 13.3 6.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF572 PF04502.13 CCL98989.1 - 0.079 12.6 7.6 0.11 12.1 7.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) PRKG1_interact PF15898.5 CCL98989.1 - 0.38 11.7 9.9 0.98 10.4 9.9 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Bud13 PF09736.9 CCL98989.1 - 1.8 9.0 8.2 5.2 7.5 5.9 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex HALZ PF02183.18 CCL98989.1 - 5.7 7.2 7.3 0.46 10.7 2.3 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 CCL98989.1 - 6.1 7.4 11.2 9.9 6.7 10.5 1.7 1 1 0 1 1 1 0 Cell division protein ZapB SLS PF14611.6 CCL98990.1 - 3.8e-13 49.8 0.0 7.8e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Spb1_C PF07780.12 CCL98991.1 - 3.7e-82 275.1 24.9 3.7e-82 275.1 24.9 3.1 2 1 1 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 CCL98991.1 - 1.3e-55 188.2 0.1 1.1e-54 185.2 0.0 2.3 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.8 CCL98991.1 - 2.5e-44 151.0 2.4 2.5e-44 151.0 2.4 5.3 5 1 1 6 6 6 1 Domain of unknown function (DUF3381) Tox-SHH PF15652.6 CCL98991.1 - 6.9 7.7 7.6 5.9 7.9 3.4 3.1 3 0 0 3 3 3 0 HNH/Endo VII superfamily toxin with a SHH signature NRDE-2 PF08424.10 CCL98994.1 - 1.1e-68 231.8 0.7 3.3e-68 230.2 0.1 2.0 2 0 0 2 2 2 1 NRDE-2, necessary for RNA interference TPR_19 PF14559.6 CCL98994.1 - 0.004 17.6 4.4 3.2 8.3 0.0 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCL98994.1 - 0.011 16.4 12.0 4.6 8.3 0.2 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCL98994.1 - 0.06 13.6 1.9 0.11 12.8 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Sec39 PF08314.11 CCL98995.1 - 1.5e-97 327.9 0.0 2.2e-97 327.4 0.0 1.1 1 0 0 1 1 1 1 Secretory pathway protein Sec39 UPF0113_N PF17833.1 CCL98995.1 - 1e-27 96.5 0.0 2.6e-27 95.2 0.0 1.8 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 CCL98995.1 - 1.5e-25 89.3 0.0 2.7e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain Cgr1 PF03879.14 CCL98997.1 - 2.6e-22 79.3 15.4 3.1e-22 79.0 15.4 1.0 1 0 0 1 1 1 1 Cgr1 family RF-1 PF00472.20 CCL98997.1 - 0.0013 18.6 4.5 0.0016 18.3 4.5 1.2 1 0 0 1 1 1 1 RF-1 domain DUF737 PF05300.11 CCL98997.1 - 0.094 13.1 9.0 0.11 12.9 9.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF737) FemAB PF02388.16 CCL98997.1 - 2 7.2 5.7 2.2 7.1 5.7 1.0 1 0 0 1 1 1 0 FemAB family Pep3_Vps18 PF05131.14 CCL98998.1 - 1e-46 158.5 0.0 2e-46 157.5 0.0 1.5 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 CCL98998.1 - 3.1e-06 27.1 0.3 0.00036 20.4 0.0 3.4 3 1 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.9 CCL98998.1 - 9.1e-06 26.1 0.1 2.4e-05 24.7 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 CCL98998.1 - 4.6e-05 23.3 3.3 4.9e-05 23.2 1.1 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 CCL98998.1 - 0.00031 20.4 3.6 0.00031 20.4 3.6 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCL98998.1 - 0.00047 20.0 1.8 0.00047 20.0 1.8 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCL98998.1 - 0.0006 19.8 0.6 0.0006 19.8 0.6 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCL98998.1 - 0.00093 19.5 3.8 0.0014 18.9 1.1 2.4 2 0 0 2 2 2 1 Ring finger domain Zn_ribbon_17 PF17120.5 CCL98998.1 - 0.0016 18.0 0.9 0.0048 16.5 0.9 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C2H2_aberr PF17017.5 CCL98998.1 - 0.076 13.1 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Aberrant zinc-finger zf-C3HC4 PF00097.25 CCL98998.1 - 0.13 12.1 3.9 0.099 12.5 1.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCL98998.1 - 0.87 9.9 3.9 1.2 9.5 1.0 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 CCL98998.1 - 2.4 8.1 4.4 31 4.5 0.0 2.6 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 UreD PF01774.17 CCL98999.1 - 1.4e-67 227.8 0.0 1.6e-67 227.5 0.0 1.0 1 0 0 1 1 1 1 UreD urease accessory protein MFS_1 PF07690.16 CCL99000.1 - 8.5e-31 107.1 26.1 1.1e-30 106.8 26.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3040 PF11239.8 CCL99000.1 - 3.5 7.9 8.3 5 7.5 0.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) tRNA-synt_2 PF00152.20 CCL99001.1 - 6.8e-84 281.6 0.0 9.2e-84 281.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Ribo_biogen_C PF04034.13 CCL99001.1 - 1.8e-43 147.3 0.0 3.5e-43 146.4 0.0 1.5 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal LSM PF01423.22 CCL99001.1 - 7.4e-19 67.2 1.0 1.4e-18 66.3 1.0 1.5 1 0 0 1 1 1 1 LSM domain RLI PF04068.15 CCL99001.1 - 3.5e-11 42.7 0.0 6.4e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI tRNA_anti-codon PF01336.25 CCL99001.1 - 2.1e-08 34.0 0.1 4e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SM-ATX PF14438.6 CCL99001.1 - 0.036 14.2 0.1 0.086 13.0 0.1 1.6 1 0 0 1 1 1 0 Ataxin 2 SM domain BPL_C PF02237.17 CCL99001.1 - 0.16 11.9 0.2 0.4 10.6 0.2 1.7 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain CBM60 PF16841.5 CCL99001.1 - 0.18 12.2 0.1 0.58 10.6 0.1 1.9 1 1 0 1 1 1 0 Ca-dependent carbohydrate-binding module xylan-binding PPR_2 PF13041.6 CCL99002.1 - 1.4e-41 140.4 0.0 5.7e-13 48.8 0.0 13.2 11 3 4 15 15 15 8 PPR repeat family PPR PF01535.20 CCL99002.1 - 4.9e-38 126.7 3.6 6.8e-06 26.0 0.0 12.6 14 0 0 14 14 14 6 PPR repeat PPR_1 PF12854.7 CCL99002.1 - 1.3e-30 104.8 0.1 1.7e-08 34.0 0.0 10.1 11 0 0 11 11 11 4 PPR repeat PPR_3 PF13812.6 CCL99002.1 - 8.4e-26 89.8 0.0 2.4e-08 33.9 0.0 10.1 7 3 5 12 12 12 4 Pentatricopeptide repeat domain PPR_long PF17177.4 CCL99002.1 - 1.7e-18 66.8 1.1 1.2e-10 41.1 0.2 5.2 4 1 1 5 5 5 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 CCL99002.1 - 3.7e-09 36.6 7.9 9.4 7.4 0.1 10.1 10 1 1 11 11 11 2 Tetratricopeptide repeat COX5A PF02284.16 CCL99002.1 - 0.004 17.1 0.0 12 6.0 0.0 3.3 2 1 1 3 3 3 2 Cytochrome c oxidase subunit Va RPM2 PF08579.11 CCL99002.1 - 0.061 13.7 0.0 27 5.2 0.0 3.6 4 0 0 4 4 4 0 Mitochondrial ribonuclease P subunit (RPM2) Thioredoxin PF00085.20 CCL99003.1 - 1.9e-47 159.5 0.0 3.2e-24 84.9 0.0 3.3 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CCL99003.1 - 1.7e-18 67.2 0.0 9.1e-14 51.8 0.0 3.1 2 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CCL99003.1 - 8.3e-06 26.1 0.0 0.37 11.1 0.0 4.2 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.6 CCL99003.1 - 0.0002 21.8 0.3 0.019 15.4 0.1 3.5 3 1 0 3 3 3 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CCL99003.1 - 0.00029 20.3 0.0 2.2 7.5 0.0 3.2 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 CCL99003.1 - 0.0029 17.6 0.0 0.19 11.8 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_7 PF13899.6 CCL99003.1 - 0.098 12.9 0.1 0.53 10.5 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like TraF PF13728.6 CCL99003.1 - 0.26 11.1 0.1 0.26 11.1 0.1 3.0 3 1 1 4 4 4 0 F plasmid transfer operon protein SCO1-SenC PF02630.14 CCL99004.1 - 2.6e-46 156.9 0.0 5.2e-46 155.9 0.0 1.5 1 0 0 1 1 1 1 SCO1/SenC CGI-121 PF08617.10 CCL99004.1 - 1.1e-44 152.4 0.0 1.7e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Kinase binding protein CGI-121 AhpC-TSA PF00578.21 CCL99004.1 - 9.5e-07 28.8 0.0 3.6e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CCL99004.1 - 0.0021 18.3 0.0 0.0049 17.2 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like NDUF_B7 PF05676.13 CCL99005.1 - 1.5e-31 107.9 5.1 1.7e-31 107.7 5.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 CCL99005.1 - 0.021 14.8 2.5 0.031 14.3 2.5 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF4887 PF16228.5 CCL99006.1 - 0.13 12.4 17.3 0.28 11.3 17.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) PRP38_assoc PF12871.7 CCL99006.1 - 0.77 10.4 19.8 0.56 10.8 11.6 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Transformer PF06495.11 CCL99006.1 - 0.83 9.7 18.7 0.12 12.5 9.1 2.6 2 0 0 2 2 2 0 Fruit fly transformer protein CNDH2_M PF16869.5 CCL99006.1 - 1.5 9.5 7.2 18 6.0 7.2 2.5 1 1 0 1 1 1 0 PF16858 Tcf25 PF04910.14 CCL99007.1 - 1.4e-103 346.7 0.0 1.9e-103 346.2 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 FGE-sulfatase PF03781.16 CCL99008.1 - 1.6e-21 77.0 0.7 9.4e-12 45.0 0.0 2.1 2 0 0 2 2 2 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 CCL99008.1 - 2.2e-08 34.7 0.7 5.4e-07 30.2 1.5 2.5 2 0 0 2 2 2 1 DinB superfamily p450 PF00067.22 CCL99010.1 - 4.6e-63 213.6 0.0 2.9e-62 210.9 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCL99011.1 - 1.2e-69 235.3 0.0 4e-69 233.6 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 TetR_C_5 PF08360.11 CCL99012.1 - 0.036 14.2 0.2 0.19 11.9 0.2 2.2 1 0 0 1 1 1 0 QacR-like protein, C-terminal region Pox_A3L PF05288.11 CCL99012.1 - 0.19 11.7 8.4 3.7 7.6 0.1 3.5 2 1 1 3 3 3 0 Poxvirus A3L Protein COMM_domain PF07258.14 CCL99012.1 - 7.8 6.7 17.4 1.3 9.2 1.2 5.4 4 1 1 5 5 5 0 COMM domain RPW8 PF05659.11 CCL99013.1 - 0.0033 17.1 0.6 0.0033 17.1 0.6 2.5 2 1 1 3 3 3 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF745 PF05335.13 CCL99013.1 - 0.013 15.2 4.4 0.013 15.2 4.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) MPS2 PF17060.5 CCL99013.1 - 0.032 13.5 11.1 0.061 12.6 10.6 1.7 1 1 0 1 1 1 0 Monopolar spindle protein 2 BLOC1_2 PF10046.9 CCL99013.1 - 0.1 12.9 0.4 0.1 12.9 0.4 3.3 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 T2SSF PF00482.23 CCL99013.1 - 0.24 11.4 2.3 1.8 8.5 0.7 2.8 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF641 PF04859.12 CCL99013.1 - 0.76 10.1 18.7 0.25 11.7 3.4 4.2 1 1 3 4 4 4 0 Plant protein of unknown function (DUF641) Fez1 PF06818.15 CCL99013.1 - 3.3 8.1 25.8 7.9 6.9 5.6 2.6 1 1 2 3 3 3 0 Fez1 THP2 PF09432.10 CCL99013.1 - 7.4 6.6 9.2 12 5.9 0.4 3.3 1 1 1 3 3 3 0 Tho complex subunit THP2 Sec2p PF06428.11 CCL99013.1 - 8.4 6.4 22.5 0.099 12.6 3.1 4.3 2 1 2 4 4 4 0 GDP/GTP exchange factor Sec2p Ribosomal_L4 PF00573.22 CCL99014.1 - 1.1e-62 211.2 0.0 1.3e-62 210.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_S9 PF00380.19 CCL99015.1 - 1.8e-31 109.2 0.3 2.1e-31 109.0 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 BRCT_2 PF16589.5 CCL99016.1 - 5.8e-15 55.5 0.0 2.1e-13 50.5 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CCL99016.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain AT_hook PF02178.19 CCL99016.1 - 1.6 8.8 6.1 7.6 6.8 6.1 2.3 1 0 0 1 1 1 0 AT hook motif Tim17 PF02466.19 CCL99017.1 - 1.9e-06 28.2 13.7 3.7e-06 27.3 13.5 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Anophelin PF10731.9 CCL99018.1 - 0.53 10.2 3.6 0.92 9.4 3.6 1.3 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito ATXN-1_C PF12547.8 CCL99019.1 - 0.0033 17.7 0.7 81 3.7 0.0 4.7 3 2 2 5 5 5 0 Capicua transcriptional repressor modulator DUF3667 PF12412.8 CCL99019.1 - 0.028 13.9 0.0 43 3.7 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3667) AdoMet_dc PF02675.15 CCL99019.1 - 0.073 13.3 0.0 3.1 8.1 0.0 3.0 1 1 1 2 2 2 0 S-adenosylmethionine decarboxylase NUC153 PF08159.12 CCL99020.1 - 7.1e-14 51.3 0.9 7.1e-14 51.3 0.9 4.0 4 1 0 4 4 4 2 NUC153 domain CS PF04969.16 CCL99021.1 - 7.2e-19 68.6 1.1 8.6e-19 68.3 0.4 1.5 2 0 0 2 2 2 1 CS domain PINIT PF14324.6 CCL99022.1 - 6.6e-39 133.6 0.1 1e-38 133.0 0.1 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 CCL99022.1 - 1e-19 70.0 8.0 2e-19 69.1 8.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CCL99022.1 - 4.7e-08 32.7 1.2 1.2e-07 31.4 1.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 CCL99022.1 - 0.0014 18.4 2.4 0.016 15.0 0.2 3.0 3 0 0 3 3 3 1 SAP domain zf-C3HC4_2 PF13923.6 CCL99022.1 - 3.2 7.7 7.0 6.9 6.6 7.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Mito_carr PF00153.27 CCL99023.1 - 3.9e-66 219.0 6.2 6.7e-24 83.6 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ResIII PF04851.15 CCL99024.1 - 3.4e-21 76.0 0.0 6.5e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCL99024.1 - 6.1e-15 55.4 0.0 1.1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCL99024.1 - 9.6e-14 51.7 0.0 3.6e-13 49.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CCL99024.1 - 0.0079 16.5 0.0 0.028 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CCL99024.1 - 0.0097 15.2 0.0 0.022 14.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ERCC3_RAD25_C PF16203.5 CCL99024.1 - 0.019 14.2 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_16 PF13191.6 CCL99024.1 - 0.05 14.0 0.6 0.18 12.2 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain DEAD_2 PF06733.15 CCL99024.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 DEAD_2 AAA_11 PF13086.6 CCL99024.1 - 0.68 9.7 6.3 17 5.1 0.0 3.1 2 1 1 3 3 3 0 AAA domain Indigoidine_A PF04227.12 CCL99025.1 - 9.1e-123 409.3 0.3 1.5e-122 408.5 0.3 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 CCL99025.1 - 5.9e-22 78.3 0.0 8.5e-10 38.4 0.0 2.8 2 1 1 3 3 3 2 pfkB family carbohydrate kinase Questin_oxidase PF14027.6 CCL99026.1 - 1.3e-89 301.1 0.0 1.5e-89 300.9 0.0 1.0 1 0 0 1 1 1 1 Questin oxidase-like MoaE PF02391.17 CCL99028.1 - 5.3e-39 133.0 1.0 6.5e-39 132.7 1.0 1.1 1 0 0 1 1 1 1 MoaE protein Baculo_E25 PF05274.11 CCL99028.1 - 0.078 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein E25 ICE2 PF08426.10 CCL99029.1 - 1.8e-33 116.3 23.8 3.4e-20 72.5 11.3 2.9 1 1 1 2 2 2 2 ICE2 GATase_4 PF13230.6 CCL99030.1 - 2.2e-12 46.4 0.1 6.5e-10 38.4 0.0 2.4 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 CCL99030.1 - 9.1e-07 29.1 0.0 1.8e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain PGM_PMM_I PF02878.16 CCL99031.1 - 1.9e-17 63.2 0.1 1.1e-07 31.6 0.0 3.0 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 CCL99031.1 - 8.4e-11 41.9 0.3 3e-10 40.1 0.3 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 CCL99031.1 - 0.00023 21.7 0.1 0.0017 18.9 0.1 2.5 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CCL99031.1 - 0.014 15.6 0.0 0.061 13.5 0.0 2.0 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III SNAP PF14938.6 CCL99032.1 - 2.2e-108 362.0 17.3 2.5e-108 361.8 17.3 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 CCL99032.1 - 5.8e-06 26.0 8.4 0.12 12.5 0.1 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCL99032.1 - 0.00022 21.6 12.9 4.1 8.2 0.1 6.6 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCL99032.1 - 0.0019 18.4 21.8 0.024 14.9 7.1 3.6 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCL99032.1 - 0.0035 17.3 11.1 15 6.0 0.2 6.0 6 1 1 7 7 7 1 Tetratricopeptide repeat DUF410 PF04190.13 CCL99032.1 - 0.0062 16.4 6.0 0.092 12.5 6.0 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF410) TPR_8 PF13181.6 CCL99032.1 - 0.011 15.9 7.5 0.34 11.2 0.2 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Spatacsin_C PF14649.6 CCL99032.1 - 0.061 12.4 7.5 0.14 11.2 5.3 2.4 1 1 0 2 2 2 0 Spatacsin C-terminus TPR_11 PF13414.6 CCL99032.1 - 0.15 11.8 13.6 2.3 8.0 0.1 5.8 5 1 1 6 6 6 0 TPR repeat CAP PF00188.26 CCL99032.1 - 0.72 10.7 7.7 0.3 11.9 3.8 2.0 1 1 1 2 2 2 0 Cysteine-rich secretory protein family NSF PF02071.20 CCL99032.1 - 4.6 8.5 18.3 3.6 8.8 0.1 5.9 5 1 0 5 5 4 0 Aromatic-di-Alanine (AdAR) repeat DUF2235 PF09994.9 CCL99034.1 - 1.5e-78 264.0 0.0 2e-78 263.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) FMN_red PF03358.15 CCL99036.1 - 2.5e-24 85.8 0.0 4e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CCL99036.1 - 0.0022 17.8 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold RRP36 PF06102.12 CCL99037.1 - 8.9e-43 146.1 20.9 1.5e-42 145.4 20.9 1.4 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 DUF4398 PF14346.6 CCL99037.1 - 7.7 7.2 24.6 2.9 8.6 2.7 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4398) CorA PF01544.18 CCL99038.1 - 3.7e-17 62.6 3.8 5.7e-08 32.4 0.3 2.5 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein SR-25 PF10500.9 CCL99038.1 - 0.23 11.1 15.4 3.2 7.3 3.3 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein DegS PF05384.11 CCL99039.1 - 0.055 13.0 6.1 0.064 12.8 5.1 1.6 1 1 0 1 1 1 0 Sensor protein DegS DUF1489 PF07370.11 CCL99039.1 - 0.072 12.8 0.1 0.24 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1489) Uso1_p115_C PF04871.13 CCL99039.1 - 0.075 13.4 6.2 0.22 11.9 6.2 1.9 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF677 PF05055.12 CCL99039.1 - 0.11 11.4 4.5 0.16 10.8 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) DUF1664 PF07889.12 CCL99039.1 - 2.7 8.0 4.6 3.1 7.9 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Pex16 PF08610.10 CCL99040.1 - 3.8e-112 374.6 1.7 4.3e-112 374.4 1.7 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Cupin_2 PF07883.11 CCL99041.1 - 1.9e-05 24.3 0.0 3.7e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Cupin domain adh_short_C2 PF13561.6 CCL99042.1 - 3.2e-45 154.5 0.2 1.5e-44 152.3 0.2 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCL99042.1 - 2.2e-30 105.6 0.1 5.9e-21 74.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CCL99042.1 - 5.2e-07 29.7 0.0 8.1e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 KR domain IlvN PF07991.12 CCL99043.1 - 5.2e-49 166.0 0.0 7.6e-49 165.5 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CCL99043.1 - 4.9e-24 85.2 0.1 7e-24 84.7 0.1 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 CCL99043.1 - 5.8e-10 39.6 0.7 1e-09 38.8 0.1 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CCL99043.1 - 7.3e-05 23.0 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CCL99043.1 - 0.001 18.5 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CCL99043.1 - 0.046 13.7 0.1 0.45 10.5 0.1 2.2 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AdoHcyase_NAD PF00670.21 CCL99043.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.6 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF896 PF05979.12 CCL99043.1 - 0.15 12.0 0.9 0.52 10.2 0.3 2.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) RRM_1 PF00076.22 CCL99044.1 - 2e-39 133.3 0.2 2.6e-20 72.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 CCL99044.1 - 9.9e-15 55.4 2.5 6e-13 49.7 2.5 2.7 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_3 PF08777.11 CCL99044.1 - 2e-06 27.8 0.3 0.0066 16.5 0.0 2.7 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 CCL99044.1 - 0.038 13.9 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 0 Occluded RNA-recognition motif Abhydrolase_3 PF07859.13 CCL99045.1 - 2e-58 197.8 0.0 2.5e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCL99045.1 - 1.5e-07 30.7 0.2 4.6e-07 29.1 0.2 1.6 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CCL99045.1 - 0.0047 16.4 0.0 0.067 12.7 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family D-ser_dehydrat PF14031.6 CCL99046.1 - 7.2e-26 90.7 0.1 1.7e-24 86.3 0.0 2.8 3 0 0 3 3 3 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 CCL99046.1 - 1.5e-12 47.6 0.1 2.3e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DUF1929 PF09118.11 CCL99046.1 - 0.03 14.6 0.2 10 6.5 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1929) DAGK_cat PF00781.24 CCL99046.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain zf-met PF12874.7 CCL99046.1 - 0.17 12.4 0.7 1.7 9.2 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ras PF00071.22 CCL99047.1 - 4.1e-50 169.5 0.1 2e-33 115.3 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 CCL99047.1 - 1.4e-29 102.7 0.0 2.1e-28 99.0 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCL99047.1 - 1.7e-09 37.4 0.0 5e-07 29.3 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCL99047.1 - 7.7e-05 22.3 0.0 0.00016 21.3 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 CCL99047.1 - 0.0012 18.4 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 CCL99047.1 - 0.0027 17.8 0.0 0.0039 17.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATPase PF06745.13 CCL99047.1 - 0.0038 16.6 0.1 0.0063 15.9 0.1 1.3 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 CCL99047.1 - 0.0053 17.0 0.1 0.0099 16.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain DAP3 PF10236.9 CCL99047.1 - 0.014 14.6 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CCL99047.1 - 0.02 15.3 0.3 0.091 13.1 0.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 CCL99047.1 - 0.037 13.9 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 CCL99047.1 - 0.051 13.5 0.0 1.2 9.0 0.0 2.2 2 1 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 CCL99047.1 - 0.061 13.8 0.0 0.094 13.2 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 CCL99047.1 - 0.071 12.8 0.0 0.14 11.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CCL99047.1 - 0.073 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Septin PF00735.18 CCL99047.1 - 0.16 11.3 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 Septin DUF2075 PF09848.9 CCL99047.1 - 0.17 11.1 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) OppC_N PF12911.7 CCL99048.1 - 0.0014 18.6 1.6 0.0036 17.3 1.6 1.7 1 0 0 1 1 1 1 N-terminal TM domain of oligopeptide transport permease C LapA_dom PF06305.11 CCL99048.1 - 0.49 10.3 1.1 0.76 9.6 1.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain tRNA-synt_1e PF01406.19 CCL99049.1 - 4.3e-127 423.6 0.2 4.3e-127 423.6 0.2 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CCL99049.1 - 2.6e-08 33.0 1.3 0.0001 21.2 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCL99049.1 - 4.1e-07 28.6 0.0 1.5e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 CCL99049.1 - 6.4e-05 23.4 2.5 7.8e-05 23.1 0.0 2.5 3 0 0 3 3 3 1 DALR domain GAF_2 PF13185.6 CCL99050.1 - 0.001 19.4 0.0 0.0017 18.6 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CCL99050.1 - 0.0012 19.5 0.1 0.0018 18.9 0.1 1.4 1 0 0 1 1 1 1 GAF domain GLTP PF08718.11 CCL99051.1 - 1.2e-46 158.6 0.1 1.6e-46 158.3 0.1 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Gti1_Pac2 PF09729.9 CCL99052.1 - 2.7e-23 83.0 1.0 1.4e-20 74.2 0.0 2.1 1 1 1 2 2 2 2 Gti1/Pac2 family LysM PF01476.20 CCL99053.1 - 2.5e-05 24.3 0.0 4.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 LysM domain bZIP_2 PF07716.15 CCL99054.1 - 1.1e-09 38.3 15.4 2.5e-09 37.1 15.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCL99054.1 - 4e-05 23.6 9.7 0.0001 22.3 9.7 1.6 1 0 0 1 1 1 1 bZIP transcription factor Shugoshin_N PF07558.11 CCL99054.1 - 0.003 17.4 0.1 0.005 16.7 0.1 1.3 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region XhlA PF10779.9 CCL99054.1 - 0.036 14.3 1.8 0.064 13.5 0.1 2.0 2 0 0 2 2 2 0 Haemolysin XhlA Hamartin PF04388.12 CCL99054.1 - 0.061 12.0 7.0 0.077 11.7 7.0 1.3 1 0 0 1 1 1 0 Hamartin protein TFIIA PF03153.13 CCL99054.1 - 0.088 12.8 25.0 0.13 12.3 24.8 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TSC22 PF01166.18 CCL99054.1 - 0.11 12.8 1.0 0.27 11.6 1.0 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family WD40_alt PF14077.6 CCL99054.1 - 0.13 12.2 1.2 0.25 11.2 1.2 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif DUF4337 PF14235.6 CCL99054.1 - 0.13 12.3 7.5 1.6 8.9 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4337) DOCK_N PF16172.5 CCL99054.1 - 0.24 10.3 2.6 0.37 9.7 2.6 1.2 1 0 0 1 1 1 0 DOCK N-terminus Ndc1_Nup PF09531.10 CCL99054.1 - 2.5 6.7 14.0 3.5 6.2 14.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ASD2 PF08687.11 CCL99054.1 - 5.9 6.4 10.4 1.2 8.6 7.2 1.4 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Spt20 PF12090.8 CCL99054.1 - 8.6 5.9 18.0 14 5.2 18.0 1.3 1 0 0 1 1 1 0 Spt20 family Nucleo_P87 PF07267.11 CCL99054.1 - 9.1 5.0 14.9 6 5.6 12.6 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 zf-CCCH PF00642.24 CCL99055.1 - 2.5e-09 36.8 2.7 5.7e-09 35.7 2.7 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 CCL99055.1 - 1.4e-07 31.2 5.6 2.6e-07 30.4 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCL99055.1 - 5.7e-07 29.4 7.8 9.3e-07 28.7 7.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCL99055.1 - 1.8e-06 27.9 5.8 3.3e-06 27.0 5.8 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCL99055.1 - 1.1e-05 25.2 7.3 1.9e-05 24.4 7.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCL99055.1 - 2.8e-05 23.9 8.3 5e-05 23.1 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 CCL99055.1 - 3e-05 23.9 4.4 7e-05 22.7 4.4 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-RING_10 PF16685.5 CCL99055.1 - 0.00015 21.8 2.7 0.00032 20.8 2.7 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_2 PF13639.6 CCL99055.1 - 0.00018 21.8 6.8 0.0003 21.1 6.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-CCCH_4 PF18044.1 CCL99055.1 - 0.0019 18.0 2.9 0.004 16.9 2.9 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C3HC4_4 PF15227.6 CCL99055.1 - 0.014 15.5 7.0 0.032 14.4 7.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CCL99055.1 - 0.031 14.2 6.2 0.055 13.3 6.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 TFIIB PF00382.19 CCL99056.1 - 3.3e-35 120.0 1.0 1.4e-17 63.4 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 CCL99056.1 - 4.8e-28 97.5 2.1 4.8e-28 97.5 2.1 2.5 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 CCL99056.1 - 2.6e-08 33.2 2.2 5.9e-08 32.1 2.2 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 CCL99056.1 - 8e-05 22.4 1.2 0.056 13.2 0.6 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain DZR PF12773.7 CCL99056.1 - 0.0081 16.2 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 CCL99056.1 - 0.44 10.0 3.0 14 5.2 0.0 2.7 3 0 0 3 3 3 0 zinc-ribbon domain AP3D1 PF06375.11 CCL99056.1 - 2.3 8.4 16.2 1.5 9.1 6.4 2.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 CHAT PF12770.7 CCL99057.1 - 8.2e-29 100.9 0.0 1.4e-28 100.2 0.0 1.4 1 0 0 1 1 1 1 CHAT domain TPR_10 PF13374.6 CCL99057.1 - 0.0037 17.1 15.5 10 6.2 0.0 8.1 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCL99057.1 - 0.0047 17.0 0.0 1.1e+02 3.4 0.0 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat ubiquitin PF00240.23 CCL99058.1 - 2.1e-18 65.8 0.3 3.5e-18 65.1 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CCL99058.1 - 1.2e-10 41.0 1.5 1.3e-10 40.9 0.1 1.9 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.8 CCL99058.1 - 5e-09 35.9 0.5 9.1e-09 35.0 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCL99058.1 - 5.8e-06 26.8 0.0 1.1e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 CCL99058.1 - 0.032 14.3 0.7 1.2 9.2 0.2 2.4 1 1 1 2 2 2 0 Ubiquitin-like domain TBK1_ULD PF18396.1 CCL99058.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CCL99058.1 - 0.078 13.3 0.1 0.15 12.5 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCL99058.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RPN13_C PF16550.5 CCL99058.1 - 0.13 12.5 4.8 0.66 10.2 2.3 2.4 1 1 1 2 2 2 0 UCH-binding domain HOIP-UBA PF16678.5 CCL99058.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair STI1 PF17830.1 CCL99058.1 - 2.3 8.2 15.7 5.4 7.0 3.6 3.6 2 1 1 3 3 3 0 STI1 domain F-box-like PF12937.7 CCL99060.1 - 9.2e-07 28.7 1.3 2.4e-06 27.4 1.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCL99060.1 - 3.4e-05 23.6 0.9 7.9e-05 22.4 0.9 1.6 1 0 0 1 1 1 1 F-box domain Phage_holin_4_2 PF04020.13 CCL99061.1 - 0.32 11.7 13.4 0.39 11.4 12.2 1.6 1 1 1 2 2 2 0 Mycobacterial 4 TMS phage holin, superfamily IV RHH_4 PF13467.6 CCL99062.1 - 0.083 12.8 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Ribbon-helix-helix domain Aldo_ket_red PF00248.21 CCL99063.1 - 1.4e-68 231.3 0.0 3.2e-68 230.1 0.0 1.6 2 0 0 2 2 2 1 Aldo/keto reductase family TcpF PF06340.11 CCL99063.1 - 0.18 10.6 0.0 0.41 9.5 0.0 1.5 2 0 0 2 2 2 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F tRNA-synt_2b PF00587.25 CCL99064.1 - 1.9e-37 129.0 0.0 3.7e-37 128.0 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CCL99064.1 - 1.4e-16 60.6 8.6 2e-16 60.2 6.9 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain STE3 PF02076.15 CCL99066.1 - 0.014 14.7 0.5 0.022 14.0 0.5 1.2 1 0 0 1 1 1 0 Pheromone A receptor DUF1308 PF07000.11 CCL99066.1 - 0.049 13.6 0.5 10 6.0 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1308) DUF1547 PF07577.11 CCL99066.1 - 0.098 13.1 2.1 0.48 10.9 0.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1547) Serglycin PF04360.12 CCL99066.1 - 0.2 11.6 1.2 0.44 10.5 1.2 1.5 1 0 0 1 1 1 0 Serglycin Aldedh PF00171.22 CCL99068.1 - 2.7e-126 421.8 0.0 3.1e-126 421.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OmdA PF13376.6 CCL99068.1 - 0.075 13.0 0.6 0.15 12.1 0.6 1.4 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated LuxC PF05893.14 CCL99068.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) RNA_Me_trans PF04252.13 CCL99069.1 - 2.7e-78 262.2 0.0 3e-78 262.0 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Pkinase PF00069.25 CCL99070.1 - 1.8e-58 198.0 0.0 4.6e-58 196.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99070.1 - 7.5e-43 146.7 0.0 1.2e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 CCL99070.1 - 1.3e-36 126.3 0.1 2.7e-36 125.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) APH PF01636.23 CCL99070.1 - 0.011 15.7 0.1 0.082 12.8 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCL99070.1 - 0.015 14.1 0.0 0.03 13.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 CCL99070.1 - 0.022 14.1 0.0 0.064 12.6 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 CCL99070.1 - 0.15 11.4 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_S30 PF04758.14 CCL99071.1 - 1.3e-27 95.8 7.2 2.1e-27 95.0 7.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S30 TPR_2 PF07719.17 CCL99072.1 - 2.6e-07 30.2 1.3 0.092 12.9 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCL99072.1 - 4.7e-07 30.2 5.1 0.0026 18.2 0.4 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCL99072.1 - 5.3e-07 29.9 4.5 0.022 15.5 0.3 3.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCL99072.1 - 1.1e-06 28.7 4.1 0.00096 19.2 0.3 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCL99072.1 - 1.1e-05 25.9 2.9 0.0046 17.6 0.2 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCL99072.1 - 7e-05 22.7 1.6 1.3 9.5 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCL99072.1 - 0.00091 19.4 4.4 0.023 15.1 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCL99072.1 - 0.0012 18.5 2.0 0.077 12.8 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCL99072.1 - 0.019 14.7 0.3 13 5.6 0.3 3.1 3 0 0 3 3 3 0 TPR repeat Alkyl_sulf_dimr PF14863.6 CCL99072.1 - 0.098 13.1 0.0 7.2 7.1 0.0 2.6 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation TPR_6 PF13174.6 CCL99072.1 - 0.14 12.8 2.5 2.4 9.0 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat UPF0139 PF03669.13 CCL99073.1 - 0.0022 17.8 0.0 0.003 17.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) ORC5_C PF14630.6 CCL99074.1 - 4.9e-59 200.2 0.0 7.1e-59 199.7 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus RRF PF01765.19 CCL99075.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.4 2 0 0 2 2 2 0 Ribosome recycling factor BicD PF09730.9 CCL99075.1 - 0.098 11.1 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D BCL_N PF04714.13 CCL99076.1 - 0.0053 16.8 0.0 0.0096 16.0 0.0 1.4 1 0 0 1 1 1 1 BCL7, N-terminal conserver region Med7 PF05983.11 CCL99077.1 - 1e-50 172.5 0.0 1.2e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 MED7 protein U3_assoc_6 PF08640.11 CCL99077.1 - 0.011 15.8 0.3 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 Mating_C PF12737.7 CCL99077.1 - 0.03 13.6 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 Asp PF00026.23 CCL99078.1 - 7.4e-43 147.2 12.8 2e-42 145.7 12.8 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCL99078.1 - 5.2e-09 36.6 6.0 3.2e-05 24.3 0.3 3.1 1 1 2 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCL99078.1 - 0.00094 19.8 1.4 0.053 14.2 0.3 2.7 2 0 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.6 CCL99078.1 - 0.036 13.8 0.1 0.17 11.6 0.1 2.0 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 CCL99078.1 - 0.21 12.2 0.5 1.1 9.8 0.1 2.3 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Pam16 PF03656.13 CCL99079.1 - 5.9e-19 68.3 0.0 4.3e-13 49.4 0.0 2.1 2 0 0 2 2 2 2 Pam16 RPA43_OB PF17875.1 CCL99080.1 - 2.3e-27 96.1 0.9 3.9e-26 92.1 0.0 2.5 2 0 0 2 2 2 1 RPA43 OB domain in RNA Pol I FliE PF02049.18 CCL99081.1 - 0.29 11.3 1.3 1.4 9.1 1.3 2.2 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE zf-U1 PF06220.12 CCL99082.1 - 3.2e-12 46.0 2.0 4.8e-12 45.5 2.0 1.3 1 0 0 1 1 1 1 U1 zinc finger Chitin_synth_1 PF01644.17 CCL99083.1 - 3.3e-75 251.6 0.0 5e-75 250.9 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 CCL99083.1 - 3.3e-26 92.0 3.8 4.5e-20 71.8 0.0 2.1 1 1 1 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.11 CCL99083.1 - 1.1e-24 86.2 0.0 2.7e-24 84.9 0.0 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.6 CCL99083.1 - 4.3e-08 33.3 0.1 4.3e-08 33.3 0.1 2.2 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCL99083.1 - 0.0076 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 IMS PF00817.20 CCL99084.1 - 4.6e-49 166.3 0.0 7.3e-49 165.6 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.8 CCL99084.1 - 1.3e-06 28.4 0.0 2.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif RNF220 PF15926.5 CCL99085.1 - 0.0024 17.5 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 Amidase PF01425.21 CCL99086.1 - 4.1e-100 335.9 0.0 5.3e-100 335.5 0.0 1.1 1 0 0 1 1 1 1 Amidase Peptidase_C14 PF00656.22 CCL99087.1 - 1.9e-17 64.0 0.0 3.3e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Caspase domain APG6 PF04111.12 CCL99088.1 - 6.6e-72 241.2 0.0 1.3e-71 240.3 0.0 1.5 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 CCL99088.1 - 1.2e-28 100.3 23.7 1.2e-28 100.3 23.7 1.5 2 0 0 2 2 2 1 Apg6 coiled-coil region HTH_57 PF18679.1 CCL99088.1 - 0.42 11.0 2.8 0.56 10.6 1.8 1.7 1 1 0 1 1 1 0 ThcOx helix turn helix domain UPF0242 PF06785.11 CCL99088.1 - 2.1 8.4 14.4 3.6 7.7 14.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GCS PF03074.16 CCL99089.1 - 2.2e-127 425.4 0.0 9.5e-83 278.6 0.0 2.1 1 1 1 2 2 2 2 Glutamate-cysteine ligase GCS2 PF04107.13 CCL99089.1 - 0.027 13.8 0.0 0.057 12.7 0.0 1.4 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) SR-25 PF10500.9 CCL99089.1 - 0.81 9.3 3.0 1.3 8.6 3.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RraA-like PF03737.15 CCL99090.1 - 3.9e-37 127.7 0.0 5.5e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 Aldolase/RraA VanZ PF04892.12 CCL99091.1 - 9.7e-05 23.0 4.9 0.00028 21.5 4.9 1.8 1 1 0 1 1 1 1 VanZ like family Med9 PF07544.13 CCL99092.1 - 0.0012 18.9 0.4 0.12 12.5 0.0 3.1 2 1 1 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.12 CCL99092.1 - 0.1 13.2 0.1 0.72 10.5 0.0 2.5 3 0 0 3 3 3 0 SlyX Tim17 PF02466.19 CCL99093.1 - 6.6e-30 103.8 3.5 8.2e-30 103.4 3.5 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 CCL99093.1 - 0.024 14.7 6.1 1 9.5 1.4 3.0 2 1 0 2 2 2 0 LydA holin phage, holin superfamily III zf-4CXXC_R1 PF10497.9 CCL99094.1 - 1.5e-14 54.0 14.1 1.8e-12 47.3 14.1 2.5 1 1 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 UPF0020 PF01170.18 CCL99095.1 - 2.7e-09 37.0 0.0 2.3e-08 33.9 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 CCL99095.1 - 0.0039 16.9 0.0 2.6 7.7 0.0 2.3 2 0 0 2 2 2 2 DNA methylase N6_Mtase PF02384.16 CCL99095.1 - 0.033 13.5 0.0 0.1 11.8 0.0 1.8 1 1 0 1 1 1 0 N-6 DNA Methylase DUF43 PF01861.16 CCL99095.1 - 0.086 12.0 0.0 0.46 9.7 0.0 2.1 3 0 0 3 3 3 0 Branched-chain polyamine synthase A C-terminal domain 2OG-FeII_Oxy_2 PF13532.6 CCL99096.1 - 4.4e-21 75.9 0.0 5.6e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ATP-synt_DE_N PF02823.16 CCL99098.1 - 2.2e-17 62.7 0.1 3.2e-17 62.2 0.1 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain DUF1327 PF07041.11 CCL99098.1 - 0.14 12.2 0.0 0.49 10.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1327) FliT PF05400.13 CCL99099.1 - 0.019 15.8 0.6 0.019 15.8 0.6 3.9 4 0 0 4 4 4 0 Flagellar protein FliT GTP_EFTU PF00009.27 CCL99099.1 - 0.076 12.5 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF1117 PF06547.12 CCL99099.1 - 0.58 10.7 4.8 5.6 7.6 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1117) DUF3437 PF11919.8 CCL99099.1 - 1.7 8.6 0.0 1.7 8.6 0.0 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF3437) DUF1640 PF07798.11 CCL99099.1 - 2.1 8.3 10.7 0.23 11.5 3.7 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1640) Ribosomal_S30AE PF02482.19 CCL99099.1 - 6.3 7.7 5.8 55 4.6 1.5 2.6 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Pyrid_ox_like PF16242.5 CCL99100.1 - 5.8e-28 97.3 0.0 8.2e-28 96.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 CCL99100.1 - 6.6e-08 32.6 0.0 3.1e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase PDEase_I_N PF08499.12 CCL99100.1 - 0.068 13.0 0.1 11 6.0 0.1 2.5 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal Aminotran_3 PF00202.21 CCL99101.1 - 4e-107 358.4 0.0 5.7e-107 357.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DUF155 PF02582.14 CCL99102.1 - 2.5e-53 180.8 0.1 4.8e-53 179.9 0.1 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Cwf_Cwc_15 PF04889.12 CCL99102.1 - 0.029 14.1 3.5 0.042 13.6 3.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein MscS_porin PF12795.7 CCL99102.1 - 0.073 12.6 0.6 0.16 11.5 0.6 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CorA PF01544.18 CCL99102.1 - 0.083 12.2 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein RXT2_N PF08595.11 CCL99102.1 - 0.62 10.1 3.1 1.1 9.2 3.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal PBP1_TM PF14812.6 CCL99102.1 - 1.6 9.1 6.7 2 8.8 5.4 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GCIP PF13324.6 CCL99102.1 - 1.7 8.2 4.2 4.4 6.8 1.5 2.4 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting DNA_pol_phi PF04931.13 CCL99102.1 - 4.8 5.2 8.1 7.8 4.5 8.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sec5 PF15469.6 CCL99103.1 - 9.2e-58 195.2 1.4 1.4e-57 194.5 0.3 2.0 2 0 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.11 CCL99103.1 - 0.0078 16.3 0.1 0.028 14.5 0.1 2.0 1 0 0 1 1 1 1 Vps51/Vps67 Trimer_CC PF08954.11 CCL99103.1 - 0.39 10.3 2.6 5.7 6.6 0.1 2.8 2 0 0 2 2 2 0 Trimerisation motif NUC153 PF08159.12 CCL99104.1 - 6.5e-13 48.2 1.3 1.7e-12 46.9 1.3 1.8 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 CCL99104.1 - 0.0058 17.4 0.8 2.1 9.4 0.0 3.6 3 0 0 3 3 3 1 WD domain, G-beta repeat Menin PF05053.13 CCL99104.1 - 5 5.4 14.0 7.3 4.8 14.0 1.1 1 0 0 1 1 1 0 Menin Nop14 PF04147.12 CCL99104.1 - 9 4.4 27.0 14 3.7 27.0 1.2 1 0 0 1 1 1 0 Nop14-like family HhH-GPD PF00730.25 CCL99105.1 - 2.1e-18 66.8 0.0 4.6e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 CCL99105.1 - 1e-09 38.3 0.2 1.6e-07 31.3 0.0 3.3 2 1 0 2 2 2 1 NUDIX domain HHH PF00633.23 CCL99105.1 - 0.0035 17.1 0.0 0.0085 15.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif SURF4 PF02077.15 CCL99106.1 - 4.9e-93 311.6 5.0 5.6e-93 311.4 5.0 1.0 1 0 0 1 1 1 1 SURF4 family DUF5562 PF17717.1 CCL99106.1 - 0.044 13.8 0.3 0.098 12.6 0.3 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5562) Cyt-b5 PF00173.28 CCL99107.1 - 1.7e-21 76.2 0.0 3.1e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 CCL99107.1 - 0.058 13.7 9.5 0.12 12.7 5.8 2.2 2 0 0 2 2 2 0 Fatty acid hydroxylase superfamily FA_hydroxylase PF04116.13 CCL99108.1 - 2.1e-09 37.8 4.0 2.2e-09 37.8 4.0 1.0 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily TMEM189_B_dmain PF10520.9 CCL99108.1 - 0.007 16.5 2.4 0.013 15.6 2.4 1.5 1 1 0 1 1 1 1 B domain of TMEM189, localisation domain His_Phos_2 PF00328.22 CCL99109.1 - 6.9e-19 68.4 0.0 8.6e-12 45.1 0.0 2.8 2 2 1 3 3 3 2 Histidine phosphatase superfamily (branch 2) DEAD_2 PF06733.15 CCL99110.1 - 3.7e-52 176.5 0.0 6.2e-52 175.8 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 CCL99110.1 - 3.5e-46 157.3 2.5 3.9e-41 140.8 0.5 2.6 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 CCL99110.1 - 1.4e-43 149.0 0.0 2.7e-43 148.1 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 CCL99110.1 - 0.013 15.5 0.1 0.67 9.9 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CCL99110.1 - 0.075 12.3 0.0 3.1 7.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 CCL99110.1 - 0.14 12.5 1.2 29 4.9 0.0 3.2 2 1 1 3 3 3 0 AAA domain TPR_12 PF13424.6 CCL99111.1 - 1.1e-06 28.9 9.7 0.0098 16.2 0.4 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CCL99111.1 - 9.9e-06 25.3 2.7 1.3 9.0 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCL99111.1 - 0.0019 18.2 5.0 0.12 12.6 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCL99111.1 - 0.0022 17.7 1.5 1.1 9.2 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCL99111.1 - 0.0043 16.7 0.4 2.9 7.7 0.0 2.9 3 0 0 3 3 3 2 TPR repeat TPR_8 PF13181.6 CCL99111.1 - 0.011 15.9 0.1 5.7 7.4 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2225 PF09986.9 CCL99111.1 - 0.19 11.4 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 CCL99111.1 - 0.66 10.7 3.1 1.2e+02 3.6 0.0 3.4 3 0 0 3 3 3 0 Sel1 repeat TPR_14 PF13428.6 CCL99111.1 - 1.7 9.7 8.6 17 6.6 0.5 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCL99111.1 - 4.4 8.0 6.8 2.6 8.8 0.6 3.3 3 1 1 4 4 3 0 Tetratricopeptide repeat Peptidase_M49 PF03571.15 CCL99112.1 - 2.2e-223 742.6 0.0 2.7e-223 742.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 SpoIIE PF07228.12 CCL99113.1 - 2.2e-06 27.7 0.0 1.1e-05 25.5 0.0 2.2 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CCL99113.1 - 0.059 13.0 0.0 0.24 11.0 0.0 1.9 1 1 0 1 1 1 0 Protein phosphatase 2C Glucan_synthase PF02364.15 CCL99114.1 - 0 1303.7 0.0 0 1303.3 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 CCL99114.1 - 1.2e-41 142.1 0.0 3.4e-41 140.6 0.0 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 NblA PF04485.12 CCL99114.1 - 0.35 11.3 4.5 0.6 10.6 0.0 3.2 4 0 0 4 4 4 0 Phycobilisome degradation protein nblA RAI16-like PF10257.9 CCL99115.1 - 2.7e-68 230.5 0.3 4.6e-68 229.7 0.3 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein DnaJ PF00226.31 CCL99116.1 - 7.1e-23 80.5 1.6 7.1e-23 80.5 1.6 2.7 2 1 0 2 2 2 1 DnaJ domain GAIN_A PF18619.1 CCL99117.1 - 0.21 11.8 0.0 0.39 11.0 0.0 1.3 1 0 0 1 1 1 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A adh_short PF00106.25 CCL99119.1 - 2.8e-52 177.0 1.5 3.8e-52 176.6 1.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99119.1 - 6.2e-33 114.3 1.5 8e-33 113.9 1.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL99119.1 - 1.9e-12 47.5 0.6 2.4e-12 47.1 0.6 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCL99119.1 - 0.0021 17.6 0.4 0.0039 16.7 0.4 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCL99119.1 - 0.0038 16.7 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Helicase_RecD PF05127.14 CCL99119.1 - 0.0045 16.9 0.1 0.007 16.2 0.1 1.3 1 0 0 1 1 1 1 Helicase THF_DHG_CYH_C PF02882.19 CCL99119.1 - 0.0084 15.4 0.0 0.021 14.1 0.0 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 CCL99119.1 - 0.035 13.5 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FLgD_tudor PF13861.6 CCL99119.1 - 0.059 13.6 0.0 0.16 12.2 0.0 1.7 1 1 0 1 1 1 0 FlgD Tudor-like domain Eno-Rase_NADH_b PF12242.8 CCL99119.1 - 0.062 13.1 0.9 0.14 11.9 0.9 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3HCDH_N PF02737.18 CCL99119.1 - 0.077 12.9 0.2 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Zn_clus PF00172.18 CCL99121.1 - 6.5e-05 23.0 8.9 0.00012 22.1 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldo_ket_red PF00248.21 CCL99122.1 - 5.7e-48 163.6 0.0 6.5e-48 163.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family OTU PF02338.19 CCL99123.1 - 2.9e-19 69.8 0.0 5.5e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease DUF1018 PF06252.12 CCL99123.1 - 0.0029 18.6 1.3 0.13 13.2 1.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1018) Peptidase_C65 PF10275.9 CCL99123.1 - 0.0061 16.0 0.0 2.9 7.3 0.0 2.4 1 1 1 2 2 2 2 Peptidase C65 Otubain AP_endonuc_2 PF01261.24 CCL99123.1 - 0.046 13.2 0.1 0.26 10.7 0.1 2.1 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Co_AT_N PF12557.8 CCL99123.1 - 0.16 11.9 2.3 0.41 10.6 2.3 1.6 1 0 0 1 1 1 0 Cob(I)alamin adenosyltransferase N terminal NIL PF09383.10 CCL99123.1 - 0.19 11.6 0.0 0.53 10.2 0.0 1.7 1 0 0 1 1 1 0 NIL domain eIF3_subunit PF08597.10 CCL99123.1 - 0.57 10.1 7.1 0.78 9.6 7.1 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Adaptin_N PF01602.20 CCL99124.1 - 7.4e-123 410.9 5.7 9.8e-123 410.5 5.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCL99124.1 - 1.5e-57 194.1 0.6 1.2e-54 184.8 0.1 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCL99124.1 - 4.4e-13 49.4 10.5 3.6e-06 27.3 0.0 5.4 3 2 4 7 7 7 4 HEAT repeats HEAT PF02985.22 CCL99124.1 - 2.6e-09 36.5 3.7 0.011 15.9 0.0 5.7 6 0 0 6 6 6 3 HEAT repeat Arm PF00514.23 CCL99124.1 - 3.9e-06 26.7 4.0 0.13 12.4 0.1 5.5 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCL99124.1 - 0.00021 21.7 1.2 2.6 8.6 0.0 4.5 4 0 0 4 4 4 1 HEAT-like repeat CLASP_N PF12348.8 CCL99124.1 - 0.00051 19.7 0.0 0.0031 17.1 0.0 2.3 2 0 0 2 2 2 1 CLASP N terminal RTP1_C1 PF10363.9 CCL99124.1 - 0.00068 19.8 3.8 6.5 7.0 0.7 4.6 3 1 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 DUF5578 PF17741.1 CCL99124.1 - 0.61 9.5 3.1 2.7 7.4 0.2 2.9 3 1 0 3 3 3 0 Family of unknown function (DUF5578) DUF4477 PF14780.6 CCL99125.1 - 6.4e-08 32.5 0.1 1.1e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) Pyr_redox_2 PF07992.14 CCL99126.1 - 7e-13 48.5 0.0 8.1e-08 31.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Malic_M PF03949.15 CCL99126.1 - 0.015 14.6 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain NAD_binding_9 PF13454.6 CCL99126.1 - 0.03 14.3 0.0 5.1 7.1 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding MMR_HSR1 PF01926.23 CCL99127.1 - 2e-09 37.6 0.0 3.1e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCL99127.1 - 3.8e-08 32.9 0.0 5.4e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Septin PF00735.18 CCL99127.1 - 5.5e-05 22.6 0.0 9.4e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Septin FeoB_N PF02421.18 CCL99127.1 - 0.0002 20.9 0.1 0.00043 19.8 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCL99127.1 - 0.00038 20.6 0.5 0.38 10.8 0.1 2.4 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 CCL99127.1 - 0.00041 20.3 0.5 0.0021 18.0 0.1 2.2 2 1 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CCL99127.1 - 0.0092 16.4 0.1 0.032 14.6 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCL99127.1 - 0.011 16.0 0.1 0.03 14.6 0.0 1.8 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 CCL99127.1 - 0.014 15.9 0.9 0.037 14.5 0.9 1.9 1 1 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.12 CCL99127.1 - 0.014 14.7 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA PF00004.29 CCL99127.1 - 0.022 15.2 0.0 0.039 14.4 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CCL99127.1 - 0.042 14.2 0.0 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 CCL99127.1 - 0.048 13.4 0.1 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 CCL99127.1 - 0.068 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_19 PF13245.6 CCL99127.1 - 0.086 13.2 0.7 0.4 11.0 0.7 2.2 1 1 0 1 1 1 0 AAA domain IIGP PF05049.13 CCL99127.1 - 0.12 11.4 0.0 0.23 10.5 0.0 1.4 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_7 PF12775.7 CCL99127.1 - 0.14 11.7 0.1 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CCL99127.1 - 0.14 11.9 0.0 1.1 8.9 0.0 2.2 2 1 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.14 CCL99127.1 - 0.16 11.9 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 CCL99127.1 - 0.18 11.6 0.2 0.62 9.8 0.1 2.0 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Cu_bind_like PF02298.17 CCL99129.1 - 0.00019 21.4 0.3 0.00046 20.1 0.3 1.6 1 0 0 1 1 1 1 Plastocyanin-like domain Methyltransf_3 PF01596.17 CCL99130.1 - 2.3e-39 134.8 0.0 2.9e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CCL99130.1 - 2.1e-17 64.1 0.0 3.6e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCL99130.1 - 5.2e-09 36.1 0.0 8.8e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCL99130.1 - 8.9e-08 32.1 0.0 1.2e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CCL99130.1 - 2.7e-07 31.2 0.0 1.9e-06 28.5 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCL99130.1 - 1.6e-05 25.5 0.0 0.00017 22.2 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CCL99130.1 - 0.00064 19.4 0.0 0.00089 18.9 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 CMAS PF02353.20 CCL99130.1 - 0.015 14.6 0.0 0.036 13.4 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 CCL99130.1 - 0.056 13.4 0.0 0.14 12.1 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_15 PF09445.10 CCL99130.1 - 0.061 12.9 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MSC PF09402.10 CCL99131.1 - 2.7e-89 299.9 0.0 5.1e-89 299.0 0.0 1.4 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 CCL99131.1 - 3.1e-11 42.8 0.0 6.1e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 HeH/LEM domain UEV PF05743.13 CCL99132.1 - 3.2e-29 101.2 0.0 1.2e-28 99.4 0.0 1.9 1 1 0 1 1 1 1 UEV domain Vps23_core PF09454.10 CCL99132.1 - 5.4e-27 93.5 0.3 9.7e-27 92.7 0.3 1.4 1 0 0 1 1 1 1 Vps23 core domain FH2 PF02181.23 CCL99132.1 - 0.15 11.1 0.1 0.22 10.6 0.1 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain TEA PF01285.18 CCL99133.1 - 8.5e-15 54.6 0.5 1.4e-14 53.9 0.5 1.4 1 0 0 1 1 1 1 TEA/ATTS domain ANAPC5 PF12862.7 CCL99134.1 - 2e-10 40.6 0.2 9.6e-10 38.4 0.2 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 FAD_binding_3 PF01494.19 CCL99135.1 - 2.1e-42 145.7 0.0 2.2e-26 92.9 0.0 2.0 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CCL99135.1 - 2.4e-06 26.9 1.6 0.0017 17.4 0.9 2.8 2 1 0 2 2 2 2 Lycopene cyclase protein DAO PF01266.24 CCL99135.1 - 2.7e-06 27.2 0.6 0.00022 20.9 0.6 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCL99135.1 - 5e-05 22.7 0.9 0.0073 15.6 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCL99135.1 - 7.6e-05 22.0 1.4 0.00037 19.7 0.4 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 CCL99135.1 - 0.00018 20.9 0.4 0.00036 19.9 0.2 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCL99135.1 - 0.00023 20.7 0.4 0.00031 20.2 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 CCL99135.1 - 0.0009 19.3 0.1 0.0016 18.5 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 CCL99135.1 - 0.0011 19.5 0.2 0.38 11.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCL99135.1 - 0.0018 17.5 0.1 0.0033 16.7 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CCL99135.1 - 0.0031 16.3 0.1 0.013 14.2 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 CCL99135.1 - 0.0038 17.4 0.1 0.012 15.8 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 CCL99135.1 - 0.0048 16.0 0.0 0.007 15.4 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase ThiF PF00899.21 CCL99135.1 - 0.016 14.6 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 ThiF family TrkA_N PF02254.18 CCL99135.1 - 0.017 15.4 0.0 0.037 14.3 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Trp_halogenase PF04820.14 CCL99135.1 - 0.023 13.5 0.1 0.97 8.2 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.6 CCL99135.1 - 0.057 13.9 0.0 0.13 12.7 0.0 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_9 PF13454.6 CCL99135.1 - 0.085 12.8 0.4 0.19 11.7 0.1 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.22 CCL99135.1 - 0.21 10.6 1.9 0.97 8.4 1.9 1.9 1 1 0 1 1 1 0 Glucose inhibited division protein A Acyltransferase PF01553.21 CCL99136.1 - 2.4e-05 24.0 0.0 0.0001 22.0 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase Peptidase_M24 PF00557.24 CCL99137.1 - 5.5e-50 169.9 0.0 7.6e-50 169.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 HBS1_N PF08938.10 CCL99137.1 - 0.14 12.5 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 HBS1 N-terminus CLASP_N PF12348.8 CCL99138.1 - 6.3e-24 84.8 0.0 8.2e-09 35.4 0.0 5.4 5 0 0 5 5 5 4 CLASP N terminal HEAT PF02985.22 CCL99138.1 - 4.3e-11 42.1 14.2 0.27 11.6 0.0 11.3 11 0 0 11 11 11 2 HEAT repeat Cnd1 PF12717.7 CCL99138.1 - 1.7e-08 34.7 0.6 1.1 9.3 0.0 6.9 7 0 0 7 7 7 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCL99138.1 - 2.8e-08 34.1 9.5 1 9.8 0.1 8.1 6 2 1 7 7 7 2 HEAT repeats Acyltransferase PF01553.21 CCL99138.1 - 0.00082 19.0 0.0 0.004 16.8 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase HEAT_EZ PF13513.6 CCL99138.1 - 0.025 15.1 10.2 22 5.7 0.0 7.2 6 1 2 8 8 8 0 HEAT-like repeat TAN PF11640.8 CCL99138.1 - 0.032 14.3 5.7 0.17 12.0 0.1 4.0 4 1 0 4 4 4 0 Telomere-length maintenance and DNA damage repair Proteasom_PSMB PF10508.9 CCL99138.1 - 0.15 10.5 0.3 0.66 8.4 0.0 2.3 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit IF-2B PF01008.17 CCL99140.1 - 1e-57 195.5 0.0 7.1e-57 192.8 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family UPF0086 PF01868.16 CCL99141.1 - 2.3e-30 104.3 0.0 2.8e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Cyclin_N PF00134.23 CCL99142.1 - 0.00039 20.2 0.3 0.0031 17.2 0.3 2.3 1 1 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCL99142.1 - 0.011 15.8 0.1 0.036 14.2 0.0 1.8 2 0 0 2 2 2 0 Cyclin, C-terminal domain Ribosomal_S21 PF01165.20 CCL99144.1 - 3e-13 49.3 6.1 5.8e-13 48.3 6.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S21 Myb_Cef PF11831.8 CCL99144.1 - 0.086 12.4 0.3 0.086 12.4 0.3 1.7 2 1 0 2 2 2 0 pre-mRNA splicing factor component RWD PF05773.22 CCL99145.1 - 1.5e-16 60.7 0.1 3.5e-16 59.5 0.1 1.6 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 CCL99145.1 - 9e-08 32.5 6.4 2.7e-07 31.0 6.4 1.9 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 NPIP PF06409.11 CCL99145.1 - 0.53 9.3 3.3 0.77 8.8 3.3 1.2 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Abhydrolase_1 PF00561.20 CCL99146.1 - 1.2e-09 38.2 0.0 2.7e-09 37.1 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL99146.1 - 1.5e-06 29.0 1.1 2.1e-06 28.5 1.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL99146.1 - 2.1e-05 23.9 0.0 0.0017 17.7 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 CCL99146.1 - 0.086 11.5 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family DUF915 PF06028.11 CCL99146.1 - 0.11 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Arm PF00514.23 CCL99147.1 - 0.0084 16.1 1.3 47 4.2 0.0 5.3 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat AA_permease PF00324.21 CCL99148.1 - 4.1e-130 434.6 40.1 5.2e-130 434.2 40.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCL99148.1 - 2.9e-31 108.8 43.6 4.1e-31 108.3 43.6 1.2 1 0 0 1 1 1 1 Amino acid permease Pirin PF02678.16 CCL99149.1 - 3.2e-30 104.3 0.4 6.1e-30 103.4 0.4 1.5 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 CCL99149.1 - 2.5e-23 82.4 0.0 1.4e-22 80.0 0.0 1.9 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Sfi1 PF08457.10 CCL99150.1 - 3.7e-33 114.9 109.0 1.2e-13 50.5 34.7 5.1 1 1 4 5 5 5 5 Sfi1 spindle body protein CLTH PF10607.9 CCL99151.1 - 1.2e-20 73.9 0.0 2.6e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain MFS_1 PF07690.16 CCL99154.1 - 7e-26 91.0 22.7 7e-26 91.0 22.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCL99154.1 - 5.3e-05 22.3 0.9 5.3e-05 22.3 0.9 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter AMP-binding PF00501.28 CCL99155.1 - 1.3e-82 277.7 0.0 1.8e-82 277.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCL99155.1 - 3.3e-05 24.8 0.2 0.00012 23.0 0.2 2.0 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_transf_88 PF16849.5 CCL99155.1 - 0.059 12.3 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 88 EF-hand_6 PF13405.6 CCL99156.1 - 1.8e-17 61.7 1.1 1.3e-05 24.7 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 CCL99156.1 - 2.8e-17 60.9 0.9 3.3e-05 23.1 0.0 5.1 4 1 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCL99156.1 - 1.7e-15 57.2 0.0 5.3e-07 30.0 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCL99156.1 - 1.2e-11 43.5 0.0 0.03 13.8 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CCL99156.1 - 8.3e-09 35.2 2.2 0.002 17.9 0.1 4.0 4 0 0 4 4 4 3 EF-hand domain pair Proteasome PF00227.26 CCL99157.1 - 2.8e-60 203.1 0.0 4.7e-60 202.3 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCL99157.1 - 2e-07 30.5 0.0 7.3e-07 28.8 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature AhpC-TSA PF00578.21 CCL99158.1 - 3.9e-32 110.8 0.0 5.1e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCL99158.1 - 9.6e-15 54.6 0.0 1.4e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CCL99158.1 - 1.2e-11 44.2 0.0 2.5e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 CCL99158.1 - 0.018 15.2 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme Ssu72 PF04722.13 CCL99159.1 - 4.3e-82 274.3 0.0 5.6e-82 273.9 0.0 1.1 1 0 0 1 1 1 1 Ssu72-like protein NeA_P2 PF12312.8 CCL99159.1 - 0.14 11.6 2.9 6.8 6.1 0.7 2.2 2 0 0 2 2 2 0 Nepovirus subgroup A polyprotein F-box-like PF12937.7 CCL99160.1 - 2.5e-08 33.6 0.6 1.6e-07 31.1 0.2 2.6 3 0 0 3 3 3 1 F-box-like F-box-like_2 PF13013.6 CCL99160.1 - 0.033 14.2 0.0 0.076 13.0 0.0 1.6 1 0 0 1 1 1 0 F-box-like domain ATG16 PF08614.11 CCL99160.1 - 0.038 14.2 0.1 0.057 13.7 0.1 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) EzrA PF06160.12 CCL99160.1 - 0.063 11.5 0.3 0.088 11.0 0.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA NCBP3 PF10309.9 CCL99161.1 - 1.6e-11 43.9 0.0 3.3e-11 42.9 0.0 1.6 2 0 0 2 2 2 1 Nuclear cap-binding protein subunit 3 FoP_duplication PF13865.6 CCL99161.1 - 0.0013 19.2 10.3 0.0013 19.2 10.3 2.9 3 1 0 3 3 3 2 C-terminal duplication domain of Friend of PRMT1 KH_8 PF17903.1 CCL99162.1 - 2.6e-16 59.5 0.6 1.1e-15 57.5 0.1 2.2 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 CCL99162.1 - 0.00068 19.4 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 CCL99162.1 - 0.039 13.8 0.0 0.09 12.7 0.0 1.6 1 0 0 1 1 1 0 KH domain AMPK1_CBM PF16561.5 CCL99164.1 - 2.6e-17 62.8 0.3 4.3e-17 62.1 0.3 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Methyltransf_16 PF10294.9 CCL99165.1 - 4.3e-40 137.3 0.1 4.6e-39 133.9 0.1 2.1 1 1 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CCL99165.1 - 0.025 14.0 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 CCL99165.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) MTS PF05175.14 CCL99165.1 - 0.16 11.5 0.0 0.41 10.2 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Ribosomal_L12 PF00542.19 CCL99166.1 - 1.3e-20 73.4 3.7 4.1e-19 68.7 2.2 2.4 2 0 0 2 2 2 2 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CCL99166.1 - 1.6e-12 46.9 2.2 1.6e-12 46.9 2.2 3.2 3 0 0 3 3 3 2 Ribosomal protein L7/L12 dimerisation domain Not3 PF04065.15 CCL99167.1 - 2.4e-90 302.0 21.7 3.4e-90 301.5 21.7 1.2 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 CCL99167.1 - 4.1e-44 149.8 7.6 4.1e-44 149.8 7.6 2.5 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family Syntaxin_2 PF14523.6 CCL99167.1 - 0.0079 16.5 5.7 0.0079 16.5 5.7 2.3 1 1 1 2 2 2 1 Syntaxin-like protein MnmE_helical PF12631.7 CCL99167.1 - 1.2 9.3 7.6 2.4 8.3 7.6 1.5 1 0 0 1 1 1 0 MnmE helical domain HR1 PF02185.16 CCL99167.1 - 1.6 8.9 8.0 0.2 11.8 3.3 2.0 2 0 0 2 2 2 0 Hr1 repeat Cep57_MT_bd PF06657.13 CCL99167.1 - 2.7 8.5 8.5 0.41 11.1 1.6 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 SH3_1 PF00018.28 CCL99168.1 - 2.8e-24 84.5 0.0 7.8e-12 44.6 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CCL99168.1 - 4.2e-19 68.2 0.1 8e-09 35.2 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.17 CCL99168.1 - 3.5e-16 58.6 0.0 4.3e-09 35.9 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 CCL99168.1 - 1.5e-06 28.1 0.0 3.4e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 PX domain GH97_C PF14509.6 CCL99168.1 - 0.056 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation SOG2 PF10428.9 CCL99168.1 - 1.7 7.7 19.0 3.3 6.8 19.0 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 CCL99168.1 - 5.7 5.4 11.8 7.6 5.0 11.8 1.1 1 0 0 1 1 1 0 Macoilin family GAS2 PF02187.17 CCL99169.1 - 4.9e-13 49.0 0.0 1.5e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Asp-B-Hydro_N PF05279.11 CCL99169.1 - 1.2 9.1 22.0 3.3 7.7 22.0 1.7 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region OTT_1508_deam PF14441.6 CCL99170.1 - 5.4e-05 23.1 0.9 0.00014 21.8 0.9 1.7 1 0 0 1 1 1 1 OTT_1508-like deaminase FCD PF07729.12 CCL99170.1 - 0.045 14.2 0.7 0.35 11.3 0.1 2.6 3 0 0 3 3 3 0 FCD domain PKcGMP_CC PF16808.5 CCL99171.1 - 0.023 14.5 0.4 0.047 13.5 0.4 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Aconitase PF00330.20 CCL99172.1 - 2.8e-160 534.3 0.0 3.9e-160 533.8 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCL99172.1 - 4.1e-36 124.2 0.0 7.1e-36 123.4 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Ribosomal_L29e PF01779.17 CCL99173.1 - 2.9e-23 81.9 14.5 4e-23 81.5 14.5 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family Tau95 PF09734.9 CCL99174.1 - 4.2e-39 134.5 3.7 4.3e-39 134.5 2.0 1.9 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 CCL99174.1 - 4.9e-20 72.0 0.6 3.2e-19 69.4 0.6 2.2 1 1 0 1 1 1 1 Tau95 Triple barrel domain TraC_F_IV PF11130.8 CCL99175.1 - 0.079 12.6 0.1 3.5 7.2 0.0 2.0 1 1 1 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer PapC_C PF13953.6 CCL99176.1 - 0.081 12.7 0.0 0.6 10.0 0.0 1.9 2 0 0 2 2 2 0 PapC C-terminal domain Sld5 PF05916.11 CCL99176.1 - 0.11 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 GINS complex protein Pkr1 PF08636.10 CCL99177.1 - 1.4e-19 70.0 3.3 1.7e-19 69.7 3.3 1.0 1 0 0 1 1 1 1 ER protein Pkr1 Ferritin_2 PF13668.6 CCL99178.1 - 3.1e-35 121.3 1.7 5.5e-35 120.5 1.7 1.3 1 0 0 1 1 1 1 Ferritin-like domain Peptidase_S10 PF00450.22 CCL99179.1 - 4.2e-94 316.3 1.6 4.4e-93 313.0 1.6 1.9 1 1 0 1 1 1 1 Serine carboxypeptidase DUF3775 PF12616.8 CCL99179.1 - 0.035 14.1 0.5 0.078 13.0 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) Nop PF01798.18 CCL99180.1 - 9.2e-85 283.8 0.2 9.2e-85 283.8 0.2 1.7 2 1 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CCL99180.1 - 1.2e-21 76.8 0.1 1.2e-21 76.8 0.1 2.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain Fe_hyd_lg_C PF02906.14 CCL99182.1 - 0.015 14.9 0.0 0.02 14.6 0.0 1.1 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain DUF1993 PF09351.10 CCL99182.1 - 0.097 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) Pkinase PF00069.25 CCL99183.1 - 2e-07 30.7 0.0 3.6e-06 26.5 0.0 2.2 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99183.1 - 0.004 16.5 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCL99183.1 - 0.1 11.4 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Acetyltransf_1 PF00583.25 CCL99186.1 - 7e-05 23.1 0.1 8.5e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CCL99186.1 - 0.041 14.6 0.0 0.065 13.9 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCL99186.1 - 0.053 13.6 0.0 0.07 13.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCL99186.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein zf-CCCH_2 PF14608.6 CCL99187.1 - 5.2e-16 58.5 34.8 1.9e-05 24.9 1.7 4.3 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Acyl-CoA_dh_2 PF08028.11 CCL99189.1 - 0.088 13.1 1.0 0.2 12.0 1.0 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain E1-E2_ATPase PF00122.20 CCL99190.1 - 2.7e-33 115.0 5.2 2.7e-33 115.0 5.2 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CCL99190.1 - 1.1e-16 61.8 2.6 1.3e-07 32.1 0.4 3.0 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 CCL99190.1 - 6e-16 58.7 3.4 6e-16 58.7 3.4 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 CCL99190.1 - 1.5e-10 40.6 0.0 3e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CCL99190.1 - 4.8e-05 23.4 0.0 0.00014 21.9 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCL99190.1 - 0.0003 20.6 0.0 0.005 16.6 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Vps39_2 PF10367.9 CCL99191.1 - 0.11 13.0 1.7 0.17 12.3 0.9 1.7 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 GLTP PF08718.11 CCL99191.1 - 0.12 12.6 0.3 0.23 11.7 0.3 1.5 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) Mrpl_C PF18502.1 CCL99191.1 - 0.19 12.0 2.3 0.34 11.2 2.3 1.5 1 0 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain Fib_alpha PF08702.10 CCL99191.1 - 2.7 8.2 7.3 7.3 6.8 6.3 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SWIB PF02201.18 CCL99192.1 - 1.2e-26 92.3 0.1 2.6e-26 91.3 0.1 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 CCL99192.1 - 0.0001 22.2 0.3 0.0011 18.9 0.4 2.6 2 1 0 2 2 2 1 DEK C terminal domain Ribosomal_60s PF00428.19 CCL99192.1 - 0.00026 21.5 8.6 0.00026 21.5 8.6 3.0 3 0 0 3 3 3 1 60s Acidic ribosomal protein GREB1 PF15782.5 CCL99192.1 - 0.062 10.4 3.1 0.07 10.3 3.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2457 PF10446.9 CCL99192.1 - 0.19 10.9 17.5 0.24 10.5 17.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Hid1 PF12722.7 CCL99192.1 - 1.1 7.4 4.6 1.2 7.1 4.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein LAP1C PF05609.12 CCL99192.1 - 1.1 8.2 10.4 1.5 7.9 10.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SAPS PF04499.15 CCL99192.1 - 3.9 6.2 8.2 5.3 5.7 8.2 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PPTA PF01239.22 CCL99193.1 - 0.0098 15.6 12.1 5.3 6.9 7.8 4.9 5 0 0 5 5 5 2 Protein prenyltransferase alpha subunit repeat Ank_4 PF13637.6 CCL99194.1 - 0.011 16.3 5.0 0.11 13.1 0.1 4.3 4 1 1 5 5 5 0 Ankyrin repeats (many copies) SAP PF02037.27 CCL99194.1 - 0.049 13.4 0.0 0.096 12.5 0.0 1.5 1 0 0 1 1 1 0 SAP domain HI0933_like PF03486.14 CCL99194.1 - 0.092 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein MA3 PF02847.17 CCL99196.1 - 0.018 15.0 0.0 0.091 12.8 0.0 2.1 2 0 0 2 2 2 0 MA3 domain DUF1917 PF08939.10 CCL99197.1 - 1.8e-16 60.8 0.7 1.8e-16 60.8 0.7 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1917) Ribosomal_L32p PF01783.23 CCL99197.1 - 0.16 12.2 1.1 7.9 6.8 0.5 2.8 2 0 0 2 2 2 0 Ribosomal L32p protein family LuxS PF02664.15 CCL99197.1 - 0.18 11.5 0.7 0.38 10.4 0.7 1.5 1 0 0 1 1 1 0 S-Ribosylhomocysteinase (LuxS) Lyase_aromatic PF00221.19 CCL99198.1 - 1.8e-145 485.2 3.7 2.3e-145 484.8 3.7 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase DAO PF01266.24 CCL99199.1 - 4.2e-41 141.7 0.1 4.8e-41 141.5 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCL99199.1 - 1.3e-05 25.3 0.0 3.3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCL99199.1 - 0.0011 18.4 0.1 0.039 13.3 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CCL99199.1 - 0.0013 18.8 0.1 0.04 13.9 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCL99199.1 - 0.0014 17.8 0.3 0.017 14.3 0.3 2.1 1 1 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 CCL99199.1 - 0.0018 18.7 0.0 0.0035 17.7 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 CCL99199.1 - 0.0025 17.1 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCL99199.1 - 0.0098 14.6 0.0 2.1 7.0 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 CCL99199.1 - 0.011 15.0 0.0 0.53 9.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 CCL99199.1 - 0.012 15.0 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 ThiF family FAD_binding_3 PF01494.19 CCL99199.1 - 0.025 13.9 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 CCL99199.1 - 0.025 14.6 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 CCL99199.1 - 0.066 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Sacchrp_dh_NADP PF03435.18 CCL99199.1 - 0.073 13.3 0.0 0.22 11.8 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GIDA PF01134.22 CCL99199.1 - 0.1 11.6 0.1 3.8 6.5 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A CPSase_L_D2 PF02786.17 CCL99200.1 - 4.9e-107 356.2 0.0 4.7e-83 277.8 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CCL99200.1 - 7.2e-40 136.1 0.2 1.8e-39 134.8 0.2 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 CCL99200.1 - 1.5e-16 60.4 0.0 4.9e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCL99200.1 - 1.7e-11 44.1 0.0 6.5e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 CCL99200.1 - 2.9e-11 43.2 0.0 6.1e-05 22.8 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 CCL99200.1 - 1.7e-06 27.7 0.0 0.006 16.1 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_3 PF02655.14 CCL99200.1 - 0.00021 21.4 0.0 0.074 13.1 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 CCL99200.1 - 0.012 15.2 0.0 5.1 6.6 0.0 2.8 3 0 0 3 3 3 0 RimK-like ATP-grasp domain GARS_A PF01071.19 CCL99200.1 - 0.11 12.2 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain HLH PF00010.26 CCL99202.1 - 6.4e-09 35.6 1.9 6.8e-09 35.6 0.0 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF3138 PF11336.8 CCL99202.1 - 1.3 7.5 5.4 2.2 6.8 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF5423 PF17461.2 CCL99203.1 - 0.32 9.8 0.4 0.47 9.3 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) AA_permease_2 PF13520.6 CCL99204.1 - 3e-48 164.7 44.8 5.5e-44 150.7 29.8 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 CCL99204.1 - 1.1e-13 50.7 40.5 7.8e-13 47.8 40.5 2.1 1 1 0 1 1 1 1 Amino acid permease PepSY_TM_like_2 PF16357.5 CCL99204.1 - 0.019 14.9 0.2 0.069 13.1 0.2 1.9 1 0 0 1 1 1 0 Putative PepSY_TM-like TMEM126 PF07114.11 CCL99204.1 - 0.21 11.0 2.5 0.82 9.0 0.1 2.7 2 1 1 3 3 3 0 Transmembrane protein 126 MFS_1 PF07690.16 CCL99205.1 - 3.8e-20 72.1 46.4 2.8e-15 56.1 17.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 CCL99206.1 - 6.2e-21 74.7 44.9 6.7e-15 54.9 15.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RRM_1 PF00076.22 CCL99207.1 - 1.1e-12 47.6 0.0 2e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 CCL99207.1 - 0.0012 19.3 0.6 0.0025 18.3 0.1 1.8 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 6PF2K PF01591.18 CCL99208.1 - 1e-63 214.6 0.0 1.6e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CCL99208.1 - 2.9e-24 85.8 0.0 6.1e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CCL99208.1 - 4.3e-06 26.9 0.0 8.6e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 CCL99208.1 - 0.0021 17.6 0.0 0.004 16.6 0.0 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 Toprim_3 PF13362.6 CCL99208.1 - 0.086 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Toprim domain Transp_cyt_pur PF02133.15 CCL99209.1 - 6e-123 410.9 44.4 1.3e-90 304.3 28.5 2.0 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin SAYSvFN PF10260.9 CCL99209.1 - 0.08 12.9 3.5 0.22 11.4 2.2 2.5 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) CLTH PF10607.9 CCL99210.1 - 7.2e-31 107.1 0.1 1.2e-30 106.3 0.1 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain DNA_ligase_ZBD PF03119.16 CCL99210.1 - 0.062 13.3 1.1 0.23 11.5 0.1 2.3 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain DUF952 PF06108.12 CCL99211.1 - 0.027 14.5 0.0 6.3 6.9 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF952) Nup96 PF12110.8 CCL99212.1 - 1.3e-92 310.1 0.0 1.9e-92 309.5 0.0 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Rep_fac-A_3 PF08661.11 CCL99212.1 - 6.3e-12 45.8 0.1 1.5e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 Replication factor A protein 3 DUF3455 PF11937.8 CCL99212.1 - 4.6e-11 43.4 0.0 8.9e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) BUD22 PF09073.10 CCL99212.1 - 3.9 6.7 11.2 6.1 6.1 11.2 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 CCL99212.1 - 5.1 6.4 9.8 7.8 5.8 9.8 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CCL99212.1 - 8.5 4.5 7.4 13 3.9 7.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PIG-L PF02585.17 CCL99213.1 - 5.7e-20 72.3 0.0 8.2e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase UvrD_C_2 PF13538.6 CCL99213.1 - 0.079 12.8 0.7 0.19 11.6 0.7 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF1770 PF08589.10 CCL99214.1 - 1.8e-05 25.6 0.2 2.8e-05 25.0 0.2 1.3 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) MIOX PF05153.15 CCL99215.1 - 3.1e-126 420.0 0.3 3.9e-126 419.7 0.3 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 CCL99215.1 - 0.0019 18.4 0.0 0.25 11.6 0.0 2.9 3 0 0 3 3 3 1 HD domain DUF1796 PF08795.10 CCL99215.1 - 0.0064 16.5 0.2 0.0097 15.9 0.2 1.3 1 0 0 1 1 1 1 Putative papain-like cysteine peptidase (DUF1796) Cullin_binding PF03556.15 CCL99215.1 - 0.066 13.7 0.8 5.3 7.5 0.3 2.5 1 1 0 2 2 2 0 Cullin binding UBD PF16455.5 CCL99215.1 - 0.081 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-binding domain tRNA-synt_1d PF00750.19 CCL99216.1 - 2.8e-103 345.5 3.0 3.6e-103 345.2 3.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CCL99216.1 - 2.3e-18 66.5 0.0 4.6e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 DALR anticodon binding domain DUF2250 PF10007.9 CCL99216.1 - 0.053 13.6 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) DALR_2 PF09190.11 CCL99216.1 - 0.086 13.3 0.3 0.27 11.8 0.1 1.9 2 0 0 2 2 2 0 DALR domain DUF2009 PF09418.10 CCL99217.1 - 1.2e-195 651.0 0.0 1.4e-195 650.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 CCL99217.1 - 3.9e-05 23.7 5.4 8.1e-05 22.7 5.4 1.5 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 CCL99217.1 - 0.00017 21.8 2.5 0.00037 20.7 2.5 1.5 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain COesterase PF00135.28 CCL99218.1 - 2.7e-73 247.6 0.0 9.1e-70 236.0 0.0 2.1 1 1 1 2 2 2 2 Carboxylesterase family Peptidase_S9 PF00326.21 CCL99218.1 - 2.6e-05 23.8 0.0 4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCL99218.1 - 9.8e-05 22.3 0.0 0.00043 20.2 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pro-kuma_activ PF09286.11 CCL99219.1 - 1.4e-19 70.8 0.0 4.9e-18 65.8 0.0 2.4 1 1 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCL99219.1 - 0.0034 16.7 0.1 0.0053 16.1 0.1 1.3 1 0 0 1 1 1 1 Subtilase family Pro-kuma_activ PF09286.11 CCL99220.1 - 2.8e-35 121.7 0.0 4.1e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCL99220.1 - 4e-07 29.6 0.1 6.5e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 Subtilase family Pro-kuma_activ PF09286.11 CCL99221.1 - 3.2e-18 66.4 0.3 6.1e-17 62.2 0.1 2.7 2 1 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCL99221.1 - 2.6e-08 33.5 3.6 4.5e-08 32.7 3.6 1.3 1 0 0 1 1 1 1 Subtilase family YCII PF03795.14 CCL99222.1 - 5e-10 39.7 0.0 6.2e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Acetyltransf_1 PF00583.25 CCL99223.1 - 2.5e-06 27.7 0.0 3.8e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCL99223.1 - 0.00025 21.4 0.0 0.00042 20.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCL99223.1 - 0.0014 18.5 0.0 0.0027 17.7 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CCL99223.1 - 0.0055 16.8 0.0 0.027 14.6 0.0 2.1 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 CCL99223.1 - 0.017 15.8 0.0 0.024 15.3 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Abhydrolase_1 PF00561.20 CCL99224.1 - 1.2e-11 44.8 0.0 1.8e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCL99224.1 - 0.00017 21.0 0.2 0.0048 16.2 0.0 2.4 3 0 0 3 3 3 1 Serine aminopeptidase, S33 DUF1622 PF07784.11 CCL99224.1 - 0.018 15.0 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1622) Fer4_10 PF13237.6 CCL99224.1 - 0.13 12.4 1.2 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 4Fe-4S dicluster domain An_peroxidase PF03098.15 CCL99225.1 - 6.2e-73 246.2 0.0 8.7e-73 245.7 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase p450 PF00067.22 CCL99225.1 - 8.3e-16 57.8 0.0 1.4e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 LINES_C PF14695.6 CCL99225.1 - 0.012 15.0 0.1 0.026 14.0 0.1 1.5 1 0 0 1 1 1 0 Lines C-terminus Amidase PF01425.21 CCL99226.1 - 3e-31 108.9 0.5 5.7e-31 108.0 0.5 1.3 1 0 0 1 1 1 1 Amidase SUR7 PF06687.12 CCL99227.1 - 2.6e-11 43.6 16.7 3.5e-11 43.1 16.7 1.2 1 0 0 1 1 1 1 SUR7/PalI family Corona_S2 PF01601.16 CCL99227.1 - 0.044 12.3 7.1 0.07 11.6 7.1 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Abhydrolase_3 PF07859.13 CCL99228.1 - 2.9e-40 138.4 0.1 1.1e-32 113.6 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCL99228.1 - 5.7e-12 45.2 0.0 1.8e-11 43.6 0.0 1.7 2 0 0 2 2 2 1 Steryl acetyl hydrolase COesterase PF00135.28 CCL99228.1 - 0.057 12.3 0.2 0.99 8.2 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family Arginase PF00491.21 CCL99229.1 - 1.6e-67 228.0 0.1 3.1e-67 227.0 0.1 1.4 1 1 0 1 1 1 1 Arginase family CMAS PF02353.20 CCL99230.1 - 7.6e-46 156.6 0.2 1.3e-45 155.8 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CCL99230.1 - 3.1e-05 24.6 0.0 6.5e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCL99230.1 - 0.00018 22.1 0.0 0.00039 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCL99230.1 - 0.0056 16.5 0.0 0.0094 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain An_peroxidase PF03098.15 CCL99231.1 - 1.6e-70 238.2 0.0 2.7e-70 237.4 0.0 1.3 1 0 0 1 1 1 1 Animal haem peroxidase p450 PF00067.22 CCL99231.1 - 7.8e-25 87.5 0.0 1.2e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 KAP_NTPase PF07693.14 CCL99232.1 - 0.0018 17.6 0.0 0.0023 17.2 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain AAA_16 PF13191.6 CCL99232.1 - 0.012 16.1 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CCL99232.1 - 0.1 12.6 0.0 0.63 10.0 0.0 2.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCL99232.1 - 0.16 12.5 0.0 0.38 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCL99232.1 - 0.18 11.2 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Rer1 PF03248.13 CCL99233.1 - 1.7e-76 255.7 2.2 1.9e-76 255.6 2.2 1.0 1 0 0 1 1 1 1 Rer1 family HTH_19 PF12844.7 CCL99234.1 - 0.0075 16.3 0.1 0.014 15.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DSBA PF01323.20 CCL99234.1 - 0.011 15.6 0.3 0.019 14.7 0.2 1.4 1 1 0 1 1 1 0 DSBA-like thioredoxin domain CoA_transf_3 PF02515.17 CCL99234.1 - 0.017 14.3 0.8 0.019 14.1 0.8 1.1 1 0 0 1 1 1 0 CoA-transferase family III Ad_Cy_reg PF16701.5 CCL99234.1 - 0.037 13.8 0.2 0.079 12.7 0.1 1.5 1 1 0 1 1 1 0 Adenylate cyclase regulatory domain CorA PF01544.18 CCL99234.1 - 0.04 13.2 0.2 0.082 12.2 0.1 1.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Arg_repressor PF01316.21 CCL99234.1 - 0.054 13.3 0.2 0.56 10.0 0.1 2.1 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain PqqD PF05402.12 CCL99234.1 - 0.15 12.4 0.1 0.3 11.4 0.1 1.4 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) Steroid_dh PF02544.16 CCL99235.1 - 9.8e-30 103.5 5.5 5.2e-27 94.7 5.5 3.0 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CCL99235.1 - 1.3e-05 24.9 1.6 0.0002 20.9 1.6 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Foie-gras_1 PF11817.8 CCL99236.1 - 7.2e-37 127.4 4.4 9.7e-35 120.4 2.1 3.0 2 1 0 2 2 2 1 Foie gras liver health family 1 Gryzun PF07919.12 CCL99236.1 - 2.6e-17 62.8 0.0 7.2e-17 61.4 0.0 1.6 2 0 0 2 2 2 1 Gryzun, putative trafficking through Golgi TPR_12 PF13424.6 CCL99236.1 - 0.0055 17.0 0.2 0.0055 17.0 0.2 3.7 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCL99236.1 - 0.0071 16.1 0.2 0.056 13.3 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Gryzun-like PF12742.7 CCL99236.1 - 0.019 15.0 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking TPR_7 PF13176.6 CCL99236.1 - 0.033 14.2 2.5 0.063 13.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCL99236.1 - 0.059 13.6 0.0 0.28 11.5 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCL99236.1 - 0.065 13.1 0.1 0.3 11.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCL99236.1 - 0.067 13.9 0.2 0.39 11.5 0.2 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCL99236.1 - 0.1 12.8 0.0 0.1 12.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Aldo_ket_red PF00248.21 CCL99237.1 - 2.1e-74 250.3 0.0 2.4e-74 250.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Hexapep PF00132.24 CCL99238.1 - 4.9e-11 41.9 16.2 2.2e-07 30.3 2.2 4.5 4 1 1 5 5 5 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CCL99238.1 - 8.3e-05 22.3 14.2 0.00061 19.5 4.1 3.7 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 CCL99238.1 - 0.00092 18.3 0.0 0.0013 17.7 0.0 1.2 1 0 0 1 1 1 1 L-fucokinase AAA_16 PF13191.6 CCL99239.1 - 0.052 13.9 0.0 0.22 11.9 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain FMN_dh PF01070.18 CCL99240.1 - 4.5e-119 397.6 0.1 5.4e-119 397.3 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCL99240.1 - 6.5e-20 71.1 0.0 1.2e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CCL99240.1 - 6.1e-05 22.3 0.0 9.5e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCL99240.1 - 0.00068 18.7 0.1 0.0014 17.7 0.1 1.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain MT0933_antitox PF14013.6 CCL99240.1 - 0.065 13.5 0.4 0.17 12.2 0.4 1.7 1 0 0 1 1 1 0 MT0933-like antitoxin protein PEP_mutase PF13714.6 CCL99241.1 - 5.6e-46 156.9 2.7 6.6e-46 156.7 2.7 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CCL99241.1 - 3.6e-19 68.6 0.3 4.9e-19 68.2 0.3 1.1 1 0 0 1 1 1 1 Isocitrate lyase family PEP_hydrolase PF09370.10 CCL99241.1 - 0.046 12.9 0.0 0.12 11.6 0.0 1.7 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like FMN_dh PF01070.18 CCL99242.1 - 4.1e-123 410.8 0.1 5e-123 410.6 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCL99242.1 - 2.1e-20 72.6 0.0 4.3e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 CCL99242.1 - 2.3e-07 30.2 0.6 2.1e-05 23.7 0.1 2.6 2 1 1 3 3 3 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CCL99242.1 - 9.6e-05 21.7 0.0 0.00017 20.9 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 CCL99242.1 - 0.0024 17.2 0.1 1 8.6 0.0 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 CCL99242.1 - 0.039 13.3 0.1 0.056 12.8 0.1 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase Salt_tol_Pase PF09506.10 CCL99242.1 - 0.16 10.7 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) TrkH PF02386.16 CCL99243.1 - 5.2e-107 358.4 13.9 5.8e-106 354.9 7.5 2.1 2 0 0 2 2 2 2 Cation transport protein Arrestin_N PF00339.29 CCL99244.1 - 2.3e-11 43.9 0.0 1.5e-08 34.9 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CCL99244.1 - 6.9e-09 36.3 0.0 1.5e-06 28.7 0.0 3.3 3 1 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain PTH2 PF01981.16 CCL99245.1 - 4.6e-08 33.4 0.0 1.8e-05 25.0 0.0 2.1 2 0 0 2 2 2 2 Peptidyl-tRNA hydrolase PTH2 GST_N_3 PF13417.6 CCL99246.1 - 1.5e-20 73.3 0.0 3e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCL99246.1 - 3.8e-18 65.5 0.0 9.9e-18 64.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CCL99246.1 - 2.8e-11 43.6 0.1 2e-10 40.8 0.2 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCL99246.1 - 8.4e-07 28.9 0.5 8.4e-07 28.9 0.5 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCL99246.1 - 6e-05 23.6 0.0 9.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCL99246.1 - 0.0082 16.3 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 CCL99246.1 - 0.081 13.2 0.0 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 Glutaredoxin Tim17 PF02466.19 CCL99247.1 - 3.3e-33 114.4 8.2 4e-33 114.1 8.2 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family ABA_WDS PF02496.16 CCL99247.1 - 0.11 13.0 0.8 7.2 7.2 0.1 2.5 2 1 0 2 2 2 0 ABA/WDS induced protein LCM PF04072.14 CCL99248.1 - 4.3e-25 88.8 0.0 9e-25 87.7 0.0 1.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Amidohydro_1 PF01979.20 CCL99249.1 - 4.1e-44 151.3 0.2 5.3e-44 150.9 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCL99249.1 - 1.2e-16 61.3 0.6 4.5e-10 39.6 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family HSP70 PF00012.20 CCL99250.1 - 9.9e-261 866.2 13.7 1.2e-260 865.9 13.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCL99250.1 - 1.5e-15 56.9 2.4 1.5e-13 50.3 0.9 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 CCL99250.1 - 1.7 9.1 12.8 6 7.3 0.1 4.3 3 3 0 3 3 3 0 Cell division protein FtsA APH PF01636.23 CCL99251.1 - 2.3e-34 119.4 0.0 4.2e-34 118.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCL99251.1 - 0.0037 16.9 0.0 0.015 14.9 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase EcKinase PF02958.20 CCL99251.1 - 0.0051 16.2 0.0 0.0094 15.3 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase HET PF06985.11 CCL99252.1 - 1e-30 107.0 0.0 2.1e-30 106.0 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TMEM70 PF06979.12 CCL99252.1 - 1.5e-06 28.7 0.3 2.9e-06 27.7 0.3 1.5 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex BTB PF00651.31 CCL99253.1 - 2.2e-07 31.1 0.0 4.3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain F-box-like PF12937.7 CCL99254.1 - 6.2e-05 22.8 0.2 6.2e-05 22.8 0.2 3.1 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CCL99254.1 - 0.16 11.9 0.1 0.16 11.9 0.1 2.5 3 0 0 3 3 3 0 F-box domain WD40 PF00400.32 CCL99255.1 - 6.3e-11 42.7 0.9 0.0033 18.2 0.5 4.4 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL99255.1 - 0.00021 21.5 0.0 0.14 12.5 0.0 3.3 3 2 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCL99255.1 - 0.027 14.1 0.0 0.045 13.3 0.0 1.5 1 1 0 1 1 1 0 PQQ-like domain Cytochrom_D1 PF02239.16 CCL99255.1 - 0.054 12.0 0.0 0.068 11.7 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain Gmad1 PF10647.9 CCL99255.1 - 0.13 12.0 0.0 0.74 9.5 0.0 2.2 1 1 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Frtz PF11768.8 CCL99255.1 - 0.17 10.2 0.0 0.23 9.7 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF2415 PF10313.9 CCL99255.1 - 0.17 11.8 0.5 1.1 9.3 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) AMPKBI PF04739.15 CCL99256.1 - 2.8e-22 78.8 2.5 8e-18 64.5 0.1 3.9 3 1 0 3 3 3 2 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 CCL99256.1 - 6.3e-17 61.6 0.0 1e-16 60.9 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CAS_C PF12026.8 CCL99256.1 - 0.12 12.4 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Nbl1_Borealin_N PF10444.9 CCL99257.1 - 1.6e-15 56.4 1.1 3.2e-15 55.5 1.1 1.5 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal Borealin PF10512.9 CCL99257.1 - 0.0018 18.2 0.4 0.0018 18.2 0.4 4.0 4 0 0 4 4 4 2 Cell division cycle-associated protein 8 Tim54 PF11711.8 CCL99257.1 - 0.19 10.5 1.7 0.13 11.0 0.1 1.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 POP1 PF06978.11 CCL99258.1 - 1.5e-47 162.2 17.0 4.3e-26 92.2 1.4 2.7 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 CCL99258.1 - 1.1e-31 109.0 2.3 1.6e-31 108.5 0.2 2.5 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T PF01571.21 CCL99258.1 - 0.00018 21.0 0.0 0.22 10.9 0.0 2.5 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CCL99258.1 - 0.081 12.9 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain CALCOCO1 PF07888.11 CCL99259.1 - 0.0091 14.9 0.8 0.011 14.6 0.8 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 CCL99259.1 - 0.06 12.2 1.0 0.079 11.8 1.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein D123 PF07065.14 CCL99260.1 - 1.3e-91 306.9 0.0 1.5e-91 306.7 0.0 1.0 1 0 0 1 1 1 1 D123 VWA PF00092.28 CCL99262.1 - 5e-10 39.9 0.0 1.1e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CCL99262.1 - 1.8e-06 28.5 0.0 4.9e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Med25_VWA PF11265.8 CCL99262.1 - 0.00051 19.9 0.0 0.00094 19.1 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Tautomerase PF01361.21 CCL99262.1 - 0.16 11.9 0.0 0.48 10.4 0.0 1.8 1 0 0 1 1 1 0 Tautomerase enzyme EF_assoc_2 PF08356.12 CCL99263.1 - 1e-37 128.0 0.0 2.2e-37 126.9 0.0 1.6 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 CCL99263.1 - 1.7e-31 109.0 0.0 1.7e-19 70.0 0.0 2.4 2 0 0 2 2 2 2 Ras family EF_assoc_1 PF08355.12 CCL99263.1 - 1.9e-31 107.5 0.4 4.7e-31 106.2 0.4 1.7 1 0 0 1 1 1 1 EF hand associated Roc PF08477.13 CCL99263.1 - 5.8e-18 65.3 0.0 4.8e-09 36.5 0.0 2.9 2 2 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCL99263.1 - 1.4e-13 50.7 0.0 1.7e-06 27.6 0.0 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family EF-hand_6 PF13405.6 CCL99263.1 - 4.4e-10 38.7 0.4 0.00051 19.8 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CCL99263.1 - 4.3e-09 35.3 3.4 0.0016 17.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CCL99263.1 - 4.5e-09 36.6 0.3 0.0017 18.8 0.0 3.4 3 1 0 3 3 2 2 EF-hand domain pair MMR_HSR1 PF01926.23 CCL99263.1 - 3.9e-08 33.4 0.0 0.0043 17.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 CCL99263.1 - 7.8e-07 29.4 0.1 0.023 15.0 0.0 3.3 3 2 0 3 3 2 2 AAA domain AAA_16 PF13191.6 CCL99263.1 - 9.7e-07 29.3 0.0 0.067 13.6 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 CCL99263.1 - 6.9e-06 26.6 0.0 0.036 14.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CCL99263.1 - 7.7e-06 25.9 0.0 0.029 14.3 0.0 3.6 4 0 0 4 4 3 1 RsgA GTPase EF-hand_5 PF13202.6 CCL99263.1 - 8.9e-06 25.0 5.5 0.0072 15.8 0.1 2.7 2 0 0 2 2 2 2 EF hand Septin PF00735.18 CCL99263.1 - 3e-05 23.5 0.0 0.031 13.6 0.0 2.3 2 0 0 2 2 2 2 Septin AAA_33 PF13671.6 CCL99263.1 - 5.6e-05 23.3 0.1 0.79 9.9 0.0 3.6 4 1 0 4 4 3 2 AAA domain SRPRB PF09439.10 CCL99263.1 - 6.7e-05 22.4 0.1 0.033 13.6 0.0 2.7 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit NACHT PF05729.12 CCL99263.1 - 8e-05 22.6 0.0 0.16 11.9 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA PF00004.29 CCL99263.1 - 8e-05 23.1 0.0 0.15 12.5 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CCL99263.1 - 9.7e-05 22.0 0.0 0.077 12.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CCL99263.1 - 0.00015 22.3 0.0 0.25 11.9 0.0 2.5 2 0 0 2 2 2 1 ABC transporter EF-hand_10 PF14788.6 CCL99263.1 - 0.00021 21.1 2.7 0.015 15.1 0.1 2.5 2 0 0 2 2 2 1 EF hand G-alpha PF00503.20 CCL99263.1 - 0.00023 20.4 0.0 0.29 10.3 0.0 2.6 3 0 0 3 3 2 2 G-protein alpha subunit RNA_helicase PF00910.22 CCL99263.1 - 0.0006 20.2 0.0 0.89 10.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 CCL99263.1 - 0.00079 19.0 0.0 0.099 12.2 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region ATP_bind_1 PF03029.17 CCL99263.1 - 0.001 18.9 1.0 3.3 7.4 0.0 4.0 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 CCL99263.1 - 0.0012 19.1 0.0 0.68 10.2 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 CCL99263.1 - 0.0013 18.4 0.0 0.92 9.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 CCL99263.1 - 0.0015 18.3 0.0 0.16 11.7 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 CCL99263.1 - 0.0027 17.8 0.8 19 5.3 0.0 3.3 2 1 0 3 3 3 0 Dynamin family DUF815 PF05673.13 CCL99263.1 - 0.003 16.8 0.0 0.33 10.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 CCL99263.1 - 0.0033 16.6 0.0 0.35 10.0 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Viral_helicase1 PF01443.18 CCL99263.1 - 0.0047 16.7 0.0 0.24 11.1 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase TniB PF05621.11 CCL99263.1 - 0.0051 16.2 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein MCM PF00493.23 CCL99263.1 - 0.0059 15.7 0.0 0.03 13.4 0.0 1.9 2 0 0 2 2 2 1 MCM P-loop domain VirE PF05272.11 CCL99263.1 - 0.0069 16.1 0.1 3 7.5 0.0 2.9 3 0 0 3 3 3 1 Virulence-associated protein E Zeta_toxin PF06414.12 CCL99263.1 - 0.0069 15.7 0.0 2.2 7.5 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Ploopntkinase3 PF18751.1 CCL99263.1 - 0.0076 16.2 0.0 0.81 9.6 0.0 2.2 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 TsaE PF02367.17 CCL99263.1 - 0.011 15.7 0.0 2.7 8.0 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 CCL99263.1 - 0.012 15.2 0.0 0.87 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain NOG1 PF06858.14 CCL99263.1 - 0.013 15.3 0.2 1.3 8.9 0.1 2.7 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) SPARC_Ca_bdg PF10591.9 CCL99263.1 - 0.013 15.8 2.7 1 9.7 0.0 2.9 3 0 0 3 3 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_23 PF13476.6 CCL99263.1 - 0.014 15.9 0.1 2.1 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCL99263.1 - 0.015 15.0 0.0 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CCL99263.1 - 0.015 15.3 0.0 0.6 10.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 CCL99263.1 - 0.02 14.3 0.0 3.3 7.0 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 CCL99263.1 - 0.031 13.9 0.0 1.9 8.0 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 CCL99263.1 - 0.046 12.6 0.0 1.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATPase_2 PF01637.18 CCL99263.1 - 0.07 13.0 0.2 1.6 8.6 0.0 2.5 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 CCL99263.1 - 0.074 13.1 0.0 6.5 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CCL99263.1 - 0.078 12.7 0.0 7.9 6.2 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 CCL99263.1 - 0.085 12.6 0.0 1.4 8.6 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain EF-hand_8 PF13833.6 CCL99263.1 - 0.087 12.7 2.1 3.7 7.5 0.5 2.9 3 0 0 3 3 2 0 EF-hand domain pair AAA_15 PF13175.6 CCL99263.1 - 0.11 12.2 0.0 10 5.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AIG1 PF04548.16 CCL99263.1 - 0.12 11.7 0.0 0.51 9.6 0.0 1.9 2 0 0 2 2 2 0 AIG1 family AAA_21 PF13304.6 CCL99263.1 - 0.13 12.1 0.4 0.38 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CCL99263.1 - 0.16 11.9 0.0 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain F-box-like PF12937.7 CCL99264.1 - 0.0042 17.0 0.1 0.0088 15.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCL99264.1 - 0.0067 16.3 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 F-box domain PIG-U PF06728.13 CCL99265.1 - 1.9e-87 293.8 30.8 2.3e-87 293.6 30.8 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Cyclin_N PF00134.23 CCL99266.1 - 2.2e-10 40.3 0.0 2e-08 34.0 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Sigma70_r4_2 PF08281.12 CCL99266.1 - 0.13 12.0 0.5 77 3.1 0.1 3.9 4 0 0 4 4 4 0 Sigma-70, region 4 RasGEF PF00617.19 CCL99267.1 - 4e-46 157.4 0.0 7e-46 156.6 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCL99267.1 - 6.6e-22 77.7 0.2 4.5e-21 75.0 0.0 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_9 PF14604.6 CCL99267.1 - 8.5e-14 51.2 0.0 1.5e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCL99267.1 - 4.1e-12 45.6 0.0 9.6e-12 44.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCL99267.1 - 1.1e-09 37.7 0.0 2.1e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain GATA PF00320.27 CCL99268.1 - 1.8e-14 53.0 5.2 3.3e-14 52.2 5.2 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS PF00989.25 CCL99268.1 - 0.0037 17.3 0.0 0.0073 16.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 CCL99268.1 - 0.022 15.0 0.0 0.077 13.3 0.0 1.9 1 1 0 1 1 1 0 PAS fold Ins_P5_2-kin PF06090.12 CCL99271.1 - 3.2e-80 270.1 0.0 3.7e-80 269.9 0.0 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Zn_clus PF00172.18 CCL99272.1 - 4.9e-08 33.0 10.9 8.1e-08 32.3 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl-CoA_dh_1 PF00441.24 CCL99273.1 - 1.3e-41 142.3 0.1 3.1e-41 141.0 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCL99273.1 - 1.2e-38 132.2 0.0 2.5e-38 131.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCL99273.1 - 1e-24 86.5 0.0 1.9e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCL99273.1 - 4e-13 49.8 0.1 1e-12 48.5 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CCL99273.1 - 0.13 11.9 0.0 0.65 9.6 0.0 1.9 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal FAD_binding_3 PF01494.19 CCL99274.1 - 7.2e-17 61.6 0.1 1.1e-16 61.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCL99274.1 - 2.3e-09 36.9 0.0 0.00016 21.0 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCL99274.1 - 7.3e-09 35.2 0.1 1.5e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCL99274.1 - 1.1e-08 35.1 5.7 2.7e-07 30.5 5.5 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCL99274.1 - 8.1e-08 32.4 0.2 2.3e-07 31.0 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCL99274.1 - 2.4e-06 27.0 0.1 0.00027 20.3 0.6 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCL99274.1 - 1.5e-05 25.5 0.2 0.0078 16.7 0.3 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCL99274.1 - 1.6e-05 23.9 0.4 0.00042 19.1 0.3 2.1 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 CCL99274.1 - 2.1e-05 24.0 0.4 0.017 14.5 0.3 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 CCL99274.1 - 7.9e-05 21.7 2.5 0.014 14.3 0.7 2.9 2 1 0 3 3 3 2 Tryptophan halogenase FAD_oxidored PF12831.7 CCL99274.1 - 0.00032 20.2 1.2 0.00066 19.1 1.1 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 CCL99274.1 - 0.0039 16.3 0.1 0.0059 15.7 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 CCL99274.1 - 0.0081 15.4 0.1 0.018 14.3 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CCL99274.1 - 0.054 12.6 0.7 0.2 10.7 0.2 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CCL99274.1 - 0.092 12.0 0.3 0.2 10.9 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MCRA PF06100.11 CCL99274.1 - 0.13 11.1 0.0 9.8 4.8 0.1 2.3 2 0 0 2 2 2 0 MCRA family Aminotran_1_2 PF00155.21 CCL99275.1 - 1.7e-33 116.3 0.0 1.9e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II LRR_8 PF13855.6 CCL99276.1 - 1.5e-23 82.3 31.3 1.2e-06 28.2 2.1 6.3 4 1 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 CCL99276.1 - 9.5e-23 79.9 28.0 0.0028 18.0 0.1 8.4 6 1 1 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CCL99276.1 - 1.6e-08 34.3 9.4 0.053 13.0 0.1 4.2 2 1 2 4 4 4 4 Leucine-rich repeat NSP2-B_epitope PF14757.6 CCL99277.1 - 0.001 18.8 0.3 0.001 18.8 0.3 2.8 3 0 0 3 3 3 1 Immunogenic region of nsp2 protein of arterivirus polyprotein F-box-like PF12937.7 CCL99279.1 - 8.2e-11 41.6 0.8 2e-10 40.4 0.8 1.7 1 0 0 1 1 1 1 F-box-like DUF4571 PF15137.6 CCL99279.1 - 0.02 14.5 0.4 0.62 9.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4571) EHN PF06441.12 CCL99280.1 - 1.9e-33 115.0 0.1 6.7e-33 113.3 0.0 1.9 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCL99280.1 - 1e-11 45.0 0.1 1.6e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL99280.1 - 0.0051 17.4 7.5 0.0062 17.2 4.1 2.8 2 1 0 2 2 2 1 Alpha/beta hydrolase family HET PF06985.11 CCL99283.1 - 1.4e-24 87.1 0.0 3.1e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pro-kuma_activ PF09286.11 CCL99284.1 - 1.1e-40 139.2 0.3 2.8e-40 137.9 0.1 1.8 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCL99284.1 - 0.043 13.1 0.0 0.12 11.6 0.0 1.8 1 1 0 1 1 1 0 Subtilase family Pro-kuma_activ PF09286.11 CCL99285.1 - 5e-38 130.6 0.6 1.7e-37 128.9 0.0 2.2 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Nucleoporin_FG2 PF15967.5 CCL99285.1 - 3.2e-08 32.6 42.7 4.7e-08 32.0 41.6 2.0 1 1 0 1 1 1 1 Nucleoporin FG repeated region Nucleoporin_FG PF13634.6 CCL99285.1 - 1e-06 29.5 39.7 1e-06 29.5 39.7 4.3 2 1 2 4 4 4 2 Nucleoporin FG repeat region KxDL PF10241.9 CCL99285.1 - 0.099 12.9 3.2 0.77 10.1 0.2 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein Arrestin_N PF00339.29 CCL99286.1 - 0.014 15.4 0.1 5 7.2 0.0 3.2 1 1 1 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Mito_carr PF00153.27 CCL99287.1 - 9.7e-35 118.4 0.5 8.3e-17 60.9 0.1 2.9 3 0 0 3 3 3 2 Mitochondrial carrier protein NSs PF11073.8 CCL99287.1 - 0.19 11.1 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Rift valley fever virus non structural protein (NSs) like Methyltransf_16 PF10294.9 CCL99289.1 - 4.4e-11 42.8 0.0 3.5e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase ATG22 PF11700.8 CCL99290.1 - 4.8e-116 388.2 28.5 6.8e-115 384.4 28.5 1.9 1 1 0 1 1 1 1 Vacuole effluxer Atg22 like Mitofilin PF09731.9 CCL99291.1 - 6.8e-116 388.6 10.2 8.3e-116 388.3 10.2 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Apolipoprotein PF01442.18 CCL99291.1 - 6.1 6.7 30.9 0.24 11.3 5.0 3.8 2 2 1 3 3 3 0 Apolipoprotein A1/A4/E domain DUF2894 PF11445.8 CCL99291.1 - 6.1 7.3 14.3 0.31 11.5 1.9 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2894) ABC_tran PF00005.27 CCL99292.1 - 9.6e-51 171.9 0.0 1.2e-28 100.3 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCL99292.1 - 3.6e-49 167.9 13.7 2.7e-30 106.0 6.1 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CCL99292.1 - 1.5e-08 34.4 6.6 0.0025 17.3 2.8 4.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCL99292.1 - 1.5e-08 34.3 1.8 0.00025 20.7 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain T2SSE PF00437.20 CCL99292.1 - 1.1e-06 28.0 1.6 0.022 13.8 0.5 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 CCL99292.1 - 8.8e-06 26.2 1.2 0.021 15.2 0.3 2.9 2 1 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 CCL99292.1 - 9.4e-06 25.9 2.2 0.004 17.3 0.1 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_23 PF13476.6 CCL99292.1 - 9.6e-05 23.0 0.9 0.009 16.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CCL99292.1 - 0.0003 20.1 0.6 0.061 12.6 0.2 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.6 CCL99292.1 - 0.00034 20.3 0.9 0.32 10.5 0.2 2.8 2 0 0 2 2 2 2 AAA domain TrwB_AAD_bind PF10412.9 CCL99292.1 - 0.00058 18.9 0.2 0.14 11.0 0.0 2.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 CCL99292.1 - 0.00058 19.3 0.1 0.49 9.7 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_21 PF13304.6 CCL99292.1 - 0.00067 19.6 2.2 2.7 7.7 0.0 3.8 4 0 0 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CCL99292.1 - 0.0012 18.9 0.7 0.55 10.3 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CCL99292.1 - 0.0018 18.5 2.8 1.5 9.0 0.2 3.1 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CCL99292.1 - 0.0026 17.7 0.4 0.19 11.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CCL99292.1 - 0.0031 17.6 0.0 1.9 8.5 0.0 2.5 2 0 0 2 2 2 1 Dynamin family DUF2075 PF09848.9 CCL99292.1 - 0.0049 16.2 0.1 0.49 9.6 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 CCL99292.1 - 0.0082 15.9 0.2 1.6 8.4 0.0 2.6 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase cobW PF02492.19 CCL99292.1 - 0.02 14.5 2.2 2 8.0 0.4 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 CCL99292.1 - 0.02 14.9 0.0 7.5 6.6 0.0 3.0 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 CCL99292.1 - 0.021 15.4 0.1 2.3 8.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CCL99292.1 - 0.026 14.0 0.3 6.5 6.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DEAD PF00270.29 CCL99292.1 - 0.042 13.6 1.3 5.1 6.8 0.7 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_33 PF13671.6 CCL99292.1 - 0.051 13.7 0.5 9.2 6.4 0.1 2.7 2 1 0 2 2 2 0 AAA domain FKBP_N_2 PF18023.1 CCL99292.1 - 0.068 13.3 0.0 0.19 11.9 0.0 1.7 2 0 0 2 2 1 0 BDBT FKBP like N-terminal RNA_helicase PF00910.22 CCL99292.1 - 0.11 12.9 1.2 9.3 6.7 0.0 2.7 3 0 0 3 3 2 0 RNA helicase NACHT PF05729.12 CCL99292.1 - 0.11 12.4 3.7 4.8 7.1 0.4 2.9 3 0 0 3 3 2 0 NACHT domain AAA_15 PF13175.6 CCL99292.1 - 0.13 11.9 0.1 6.9 6.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain ResIII PF04851.15 CCL99292.1 - 0.14 12.2 0.0 13 5.7 0.0 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CCL99292.1 - 0.14 11.8 3.2 8.7 6.0 0.2 3.0 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCL99292.1 - 0.16 11.1 1.4 10 5.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Trehalase PF01204.18 CCL99293.1 - 1.3e-157 525.7 0.0 1.7e-157 525.4 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 CCL99293.1 - 2.3e-14 52.8 0.2 4e-14 52.0 0.2 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Lipase_3 PF01764.25 CCL99294.1 - 5.5e-08 32.8 0.0 9.5e-07 28.8 0.0 2.3 1 1 1 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCL99294.1 - 0.02 15.5 3.4 0.021 15.4 1.3 1.9 2 1 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 CCL99294.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 CCL99294.1 - 0.16 11.7 0.1 0.29 10.8 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.8 CCL99294.1 - 0.19 11.0 0.2 0.43 9.8 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 UNC119_bdg PF15435.6 CCL99296.1 - 0.25 10.9 0.9 13 5.3 0.0 2.2 2 0 0 2 2 2 0 UNC119-binding protein C5orf30 homologue Asp PF00026.23 CCL99298.1 - 2.4e-39 135.6 0.3 2.1e-38 132.5 0.3 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCL99298.1 - 0.026 14.8 2.2 4.6 7.5 0.2 2.4 1 1 1 2 2 2 0 Xylanase inhibitor N-terminal Peptidase_S9 PF00326.21 CCL99300.1 - 0.0012 18.3 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 CCL99300.1 - 0.049 13.2 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Ctf8 PF09696.10 CCL99301.1 - 1.8e-16 60.7 1.9 1.1e-14 55.0 0.2 2.1 1 1 1 2 2 2 2 Ctf8 PEX11 PF05648.14 CCL99302.1 - 8.5e-11 41.7 1.6 1.3e-06 28.1 0.0 2.5 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Cation_ATPase_C PF00689.21 CCL99303.1 - 5.7e-45 153.3 6.7 5.7e-45 153.3 6.7 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CCL99303.1 - 3.6e-37 127.6 0.4 3.6e-37 127.6 0.4 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCL99303.1 - 7.7e-21 74.0 0.0 1.5e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCL99303.1 - 1.6e-15 58.0 0.6 6e-15 56.1 0.6 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCL99303.1 - 1.1e-09 37.9 0.1 2.6e-08 33.4 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCL99303.1 - 0.00042 20.1 0.5 0.0098 15.6 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase VirB3 PF05101.13 CCL99303.1 - 7 7.0 10.4 0.55 10.5 0.8 3.8 4 0 0 4 4 4 0 Type IV secretory pathway, VirB3-like protein COQ9 PF08511.11 CCL99304.1 - 7.2e-12 44.9 0.0 1.3e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 COQ9 Ost4 PF10215.9 CCL99305.1 - 0.62 9.9 2.9 0.38 10.6 0.3 2.1 2 0 0 2 2 2 0 Oligosaccaryltransferase PTPlike_phytase PF14566.6 CCL99307.1 - 5.3e-130 429.5 0.2 1.9e-43 148.3 0.0 3.9 4 0 0 4 4 4 3 Inositol hexakisphosphate Y_phosphatase PF00102.27 CCL99307.1 - 2.7e-07 30.4 0.0 0.047 13.2 0.0 3.3 3 0 0 3 3 3 3 Protein-tyrosine phosphatase DSPc PF00782.20 CCL99307.1 - 2.2e-05 24.3 0.1 0.1 12.4 0.0 3.8 4 0 0 4 4 4 1 Dual specificity phosphatase, catalytic domain NIF PF03031.18 CCL99307.1 - 0.11 12.2 0.1 0.35 10.6 0.1 1.8 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase AIP3 PF03915.13 CCL99307.1 - 0.14 11.2 0.9 0.35 9.9 0.1 2.0 2 0 0 2 2 2 0 Actin interacting protein 3 BBP1_C PF15272.6 CCL99307.1 - 0.27 11.1 0.9 23 4.8 0.0 3.1 3 0 0 3 3 3 0 Spindle pole body component BBP1, C-terminal eIF-6 PF01912.18 CCL99308.1 - 1.6e-82 275.6 0.8 1.8e-82 275.5 0.3 1.3 2 0 0 2 2 2 1 eIF-6 family Methyltransf_28 PF02636.17 CCL99309.1 - 1.3e-63 215.1 0.0 1.6e-63 214.8 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Fra10Ac1 PF09725.9 CCL99310.1 - 2.7e-47 159.9 2.4 3.9e-47 159.4 2.4 1.2 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 DnaJ_C PF01556.18 CCL99311.1 - 3.8e-38 130.9 0.1 5.2e-38 130.4 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCL99311.1 - 4.4e-28 97.2 2.1 6.3e-28 96.7 2.1 1.2 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 CCL99311.1 - 0.035 14.0 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 A repeated domain in UCH-protein DUF202 PF02656.15 CCL99312.1 - 8.1e-09 35.8 1.0 5e-08 33.3 0.6 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF202) DUF5084 PF16894.5 CCL99312.1 - 0.01 16.3 1.2 0.014 15.8 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5084) LrgB PF04172.16 CCL99312.1 - 0.05 13.1 2.5 0.093 12.2 2.5 1.4 1 1 0 1 1 1 0 LrgB-like family EamA PF00892.20 CCL99312.1 - 0.087 13.0 0.4 0.087 13.0 0.4 1.9 3 0 0 3 3 3 0 EamA-like transporter family DUF3519 PF12033.8 CCL99313.1 - 0.053 13.9 0.0 0.083 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3519) DEAD PF00270.29 CCL99314.1 - 1.7e-35 122.4 0.0 3.3e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCL99314.1 - 2e-26 92.5 0.4 8.2e-26 90.5 0.3 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CCL99314.1 - 0.032 14.0 0.0 0.081 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain CMS1 PF14617.6 CCL99314.1 - 0.038 13.3 0.1 0.095 12.0 0.1 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 CCL99314.1 - 0.092 13.0 2.0 0.3 11.4 0.8 2.4 2 1 0 2 2 2 0 AAA domain CTP_transf_like PF01467.26 CCL99315.1 - 0.015 15.5 0.1 1.8 8.8 0.1 3.1 1 1 0 1 1 1 0 Cytidylyltransferase-like NmrA PF05368.13 CCL99317.1 - 3.1e-32 112.0 0.0 3.8e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCL99317.1 - 6.4e-10 39.2 0.0 8.8e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCL99317.1 - 0.091 12.2 0.0 0.36 10.3 0.0 1.8 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CCL99318.1 - 4.1e-35 121.4 0.0 5.4e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCL99318.1 - 1.1e-10 41.8 0.0 1.5e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCL99319.1 - 1.4e-33 116.4 0.0 1.7e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCL99319.1 - 2e-12 47.4 0.0 3.2e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding DUF1729 PF08354.10 CCL99321.1 - 5.7e-152 505.7 0.0 9.4e-152 505.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) FAS_I_H PF18314.1 CCL99321.1 - 5.5e-76 254.7 0.0 1.4e-75 253.4 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 CCL99321.1 - 1.7e-71 239.8 0.0 3.8e-71 238.7 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 CCL99321.1 - 1.8e-71 241.3 0.0 3.1e-70 237.2 0.0 2.9 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 CCL99321.1 - 3.3e-50 169.7 0.0 1.3e-49 167.8 0.0 2.1 2 0 0 2 2 2 1 Fatty acid synthase meander beta sheet domain DUF647 PF04884.14 CCL99321.1 - 3.1e-44 151.4 0.2 7.8e-44 150.1 0.2 1.7 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis SAT PF16073.5 CCL99321.1 - 1.6e-39 136.0 0.7 1.1e-38 133.3 0.0 2.2 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 CCL99321.1 - 1.5e-27 95.6 0.5 4.8e-27 94.0 0.0 2.1 2 0 0 2 2 2 1 MaoC like domain ketoacyl-synt PF00109.26 CCL99321.1 - 1.1e-22 80.9 0.3 2.5e-22 79.7 0.3 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain FAS_N PF17828.1 CCL99321.1 - 4.4e-20 72.0 0.2 1.1e-19 70.7 0.2 1.7 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta Ketoacyl-synt_C PF02801.22 CCL99321.1 - 4.1e-16 59.1 0.0 1.1e-15 57.6 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ACPS PF01648.20 CCL99321.1 - 1.6e-14 54.0 0.0 4.3e-14 52.6 0.0 1.8 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily MaoC_dehydrat_N PF13452.6 CCL99321.1 - 1.4e-11 44.6 0.1 5.9e-11 42.6 0.0 2.1 2 0 0 2 2 1 1 N-terminal half of MaoC dehydratase Pro_CA PF00484.19 CCL99321.1 - 2e-10 41.2 0.0 7e-09 36.2 0.0 2.6 2 0 0 2 2 2 1 Carbonic anhydrase adh_short PF00106.25 CCL99321.1 - 3.6e-05 23.3 0.0 0.0014 18.1 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99321.1 - 0.00039 20.1 0.0 0.012 15.2 0.0 2.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase F-box-like PF12937.7 CCL99322.1 - 0.0021 17.9 0.6 0.0053 16.6 0.6 1.7 1 0 0 1 1 1 1 F-box-like Pectate_lyase_3 PF12708.7 CCL99324.1 - 4.9e-101 337.0 14.4 4.5e-85 284.9 9.7 2.6 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCL99324.1 - 3.6e-07 29.8 1.5 0.0074 16.0 0.0 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase DUF4957 PF16318.5 CCL99324.1 - 0.00076 19.4 0.2 1.3 8.9 0.1 2.8 1 1 0 2 2 2 2 Domain of unknown function (DUF4957) GTP_EFTU PF00009.27 CCL99325.1 - 8.4e-35 120.1 2.9 2.5e-33 115.3 2.9 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CCL99325.1 - 1.5e-25 89.3 0.0 3.8e-25 88.1 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 CCL99325.1 - 2.5e-07 30.8 0.2 5.4e-07 29.7 0.2 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CCL99325.1 - 8.2e-05 22.4 0.3 0.037 13.8 0.0 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 CCL99325.1 - 0.00032 20.2 0.0 0.00075 19.0 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family IF2_N PF04760.15 CCL99325.1 - 0.0028 17.5 0.0 0.006 16.4 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region MeaB PF03308.16 CCL99325.1 - 0.013 14.5 4.2 0.013 14.5 1.3 2.1 1 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SRPRB PF09439.10 CCL99325.1 - 0.013 14.9 0.0 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit CHORD PF04968.12 CCL99326.1 - 4.1e-51 171.6 13.6 2.2e-25 89.2 3.5 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.16 CCL99326.1 - 2.9e-13 50.6 0.0 6.7e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 CS domain Mito_carr PF00153.27 CCL99327.1 - 3.8e-07 30.0 0.7 0.13 12.2 0.2 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein 2OG-FeII_Oxy_2 PF13532.6 CCL99328.1 - 1.6e-10 41.5 0.0 1.8e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily adh_short_C2 PF13561.6 CCL99329.1 - 0.00012 21.8 0.0 0.00049 19.7 0.0 1.9 2 1 1 3 3 3 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCL99329.1 - 0.0022 17.5 0.0 0.055 12.9 0.0 2.9 2 2 0 2 2 2 1 short chain dehydrogenase WD40 PF00400.32 CCL99330.1 - 3.4e-25 87.8 3.7 1.3e-12 48.0 0.4 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL99330.1 - 5.2e-09 36.3 0.3 0.00067 19.9 0.1 3.3 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 CCL99330.1 - 8.7e-05 22.3 0.0 0.072 12.8 0.0 2.4 1 1 0 2 2 2 2 TUP1-like enhancer of split Nucleoporin_N PF08801.11 CCL99330.1 - 0.00017 20.5 0.5 0.0028 16.5 0.2 2.7 1 1 0 2 2 2 1 Nup133 N terminal like PALB2_WD40 PF16756.5 CCL99330.1 - 0.0018 17.3 0.2 0.0088 15.0 0.0 2.0 1 1 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 CCL99330.1 - 0.0042 16.1 0.2 0.071 12.1 0.0 2.6 1 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 CCL99330.1 - 0.015 13.6 0.0 0.018 13.4 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz OGFr_III PF04680.13 CCL99330.1 - 0.019 15.6 0.8 0.044 14.4 0.1 1.9 2 0 0 2 2 2 0 Opioid growth factor receptor repeat HPS3_N PF14761.6 CCL99330.1 - 0.039 13.5 0.0 0.11 12.0 0.0 1.6 1 1 1 2 2 2 0 Hermansky-Pudlak syndrome 3 Nbas_N PF15492.6 CCL99330.1 - 0.054 12.8 0.0 20 4.4 0.0 2.9 2 1 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal GATase_2 PF00310.21 CCL99331.1 - 7.1e-169 562.0 0.0 9.3e-169 561.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CCL99331.1 - 1.8e-154 514.4 0.2 5.1e-154 512.9 0.0 1.8 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CCL99331.1 - 1.2e-115 385.8 0.0 2.4e-114 381.5 0.0 2.1 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 CCL99331.1 - 4.7e-88 293.8 3.7 7.9e-88 293.0 3.7 1.4 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 CCL99331.1 - 9.6e-25 87.4 0.0 6.8e-24 84.6 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 CCL99331.1 - 1.5e-22 79.5 0.2 2.8e-22 78.6 0.2 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox PF00070.27 CCL99331.1 - 2.9e-09 37.3 0.2 4.5e-05 23.9 0.0 4.3 4 1 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCL99331.1 - 5.7e-09 36.0 0.1 0.0013 18.4 0.0 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCL99331.1 - 1.2e-07 31.9 0.0 4.2e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCL99331.1 - 1.8e-07 30.7 0.3 0.025 13.9 0.0 3.3 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCL99331.1 - 1.7e-05 23.7 0.4 5.4e-05 22.1 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 CCL99331.1 - 0.00071 19.0 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FMN_dh PF01070.18 CCL99331.1 - 0.0019 17.3 0.7 0.0082 15.2 1.0 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase FAD_binding_2 PF00890.24 CCL99331.1 - 0.0042 16.2 0.0 0.0042 16.2 0.0 2.8 3 0 0 3 3 2 1 FAD binding domain FAD_binding_3 PF01494.19 CCL99331.1 - 0.0058 15.9 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 CCL99331.1 - 0.007 16.8 0.4 0.94 9.9 0.0 2.8 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CCL99331.1 - 0.014 14.7 0.0 0.83 8.9 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.21 CCL99331.1 - 0.019 15.0 0.2 12 6.0 0.0 2.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Thi4 PF01946.17 CCL99331.1 - 0.024 13.9 0.7 0.059 12.6 0.0 1.9 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.19 CCL99331.1 - 0.038 13.4 0.2 0.9 8.9 0.0 2.8 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GATase_6 PF13522.6 CCL99331.1 - 0.079 13.2 0.2 0.31 11.2 0.1 2.0 2 0 0 2 2 1 0 Glutamine amidotransferase domain FMO-like PF00743.19 CCL99331.1 - 0.093 11.1 0.0 4.3 5.6 0.0 2.8 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like FAD_oxidored PF12831.7 CCL99331.1 - 0.097 12.0 0.0 0.097 12.0 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase CoA_binding PF02629.19 CCL99331.1 - 0.13 13.0 0.9 1.3 9.7 0.0 3.0 3 0 0 3 3 2 0 CoA binding domain Acetyltransf_13 PF13880.6 CCL99332.1 - 1.5e-15 56.9 0.0 2.8e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 CCL99332.1 - 1.2e-09 37.9 0.3 2e-09 37.1 0.3 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 CCL99332.1 - 0.0019 18.6 0.0 0.016 15.6 0.0 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCL99332.1 - 0.04 14.1 0.0 0.076 13.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCL99332.1 - 0.18 11.8 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain WD40 PF00400.32 CCL99333.1 - 5.1e-05 24.0 11.1 0.014 16.2 0.8 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat DUF1682 PF07946.14 CCL99333.1 - 4.4 6.4 9.3 9.9 5.3 9.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) adh_short PF00106.25 CCL99334.1 - 4.8e-23 81.6 0.0 7e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99334.1 - 2e-10 40.6 0.0 2.8e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL99334.1 - 5.6e-05 23.1 0.1 0.00012 22.1 0.1 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCL99334.1 - 0.007 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 CCL99334.1 - 0.015 14.7 0.0 0.038 13.4 0.0 1.6 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) 2OG-FeII_Oxy_3 PF13640.6 CCL99335.1 - 3e-06 28.0 0.0 4.7e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DEAD PF00270.29 CCL99336.1 - 2.3e-47 161.1 0.0 3.7e-47 160.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Peptidase_M24 PF00557.24 CCL99336.1 - 5.1e-44 150.5 0.1 1e-43 149.5 0.1 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Helicase_C PF00271.31 CCL99336.1 - 8e-30 103.4 0.0 1.9e-29 102.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCL99336.1 - 2.6e-05 24.3 0.0 4.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Creatinase_N PF01321.18 CCL99336.1 - 0.0003 21.5 0.0 0.00064 20.4 0.0 1.6 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain AAA_30 PF13604.6 CCL99336.1 - 0.00041 20.1 0.1 0.0021 17.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain 2OG-FeII_Oxy_2 PF13532.6 CCL99337.1 - 1.9e-19 70.6 0.0 8.4e-13 48.9 0.0 2.3 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily DUF1296 PF06972.11 CCL99337.1 - 0.0036 17.4 0.2 0.0098 16.0 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) IGPD PF00475.18 CCL99338.1 - 1.9e-40 138.5 0.3 2.7e-39 134.7 0.0 2.1 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase SbcCD_C PF13558.6 CCL99338.1 - 0.1 12.9 0.3 0.5 10.6 0.0 2.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF4149 PF13664.6 CCL99338.1 - 0.15 12.4 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) CDC45 PF02724.14 CCL99339.1 - 5.7e-222 738.5 0.0 6.7e-222 738.3 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein Spt5_N PF11942.8 CCL99339.1 - 0.23 12.5 8.9 0.55 11.2 8.9 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Nop53 PF07767.11 CCL99339.1 - 0.3 10.4 2.9 0.43 9.9 2.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) zf-Mss51 PF13824.6 CCL99340.1 - 8.5e-26 89.8 1.5 1.6e-25 89.0 1.5 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 DUF1610 PF07754.11 CCL99340.1 - 0.71 9.9 4.2 1.7 8.6 4.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) Scramblase PF03803.15 CCL99341.1 - 3.9e-50 170.2 0.0 1.8e-49 168.0 0.0 1.8 1 1 0 1 1 1 1 Scramblase Peptidase_M13_N PF05649.13 CCL99342.1 - 5.8e-100 335.7 0.0 7.7e-100 335.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CCL99342.1 - 7e-59 198.9 0.0 1e-58 198.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 TRAPPC10 PF12584.8 CCL99343.1 - 1.1e-33 116.1 0.0 2.2e-33 115.2 0.0 1.5 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 Lyase_1 PF00206.20 CCL99345.1 - 1.2e-92 310.6 0.1 6.7e-92 308.2 0.0 2.2 3 0 0 3 3 3 1 Lyase Syntaxin PF00804.25 CCL99345.1 - 1.6e-33 116.0 8.6 2.9e-33 115.2 8.6 1.4 1 0 0 1 1 1 1 Syntaxin Far-17a_AIG1 PF04750.14 CCL99345.1 - 3e-31 108.3 4.2 5e-31 107.6 4.2 1.3 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein ASL_C2 PF14698.6 CCL99345.1 - 2.2e-24 86.0 0.0 5.8e-24 84.6 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal SNARE PF05739.19 CCL99345.1 - 1.9e-09 37.4 0.7 4.5e-09 36.2 0.7 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 CCL99345.1 - 2.6e-06 27.8 5.0 2.6e-06 27.8 5.0 2.6 2 0 0 2 2 2 1 Syntaxin-like protein Spectrin PF00435.21 CCL99345.1 - 0.0065 17.0 1.6 0.72 10.4 0.0 2.8 2 0 0 2 2 2 1 Spectrin repeat VitD-bind_III PF09164.10 CCL99345.1 - 0.02 14.9 0.1 0.051 13.6 0.1 1.6 1 0 0 1 1 1 0 Vitamin D binding protein, domain III LMBR1 PF04791.16 CCL99345.1 - 0.045 12.7 1.9 0.077 11.9 1.9 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein MCPsignal PF00015.21 CCL99345.1 - 0.11 12.3 4.8 0.076 12.8 1.3 2.4 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3394 PF11874.8 CCL99345.1 - 0.12 12.1 0.4 0.26 10.9 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) SKA1 PF07160.12 CCL99345.1 - 0.32 10.8 5.6 0.12 12.2 0.7 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF2116 PF09889.9 CCL99345.1 - 0.71 9.9 2.4 1.9 8.5 2.4 1.7 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF2951 PF11166.8 CCL99345.1 - 0.83 9.9 6.0 12 6.2 0.1 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF2951) DUF1422 PF07226.11 CCL99345.1 - 4.9 7.2 5.5 0.54 10.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) DUF16 PF01519.16 CCL99345.1 - 9.1 6.8 8.9 0.21 12.1 1.1 2.4 2 1 0 2 2 1 0 Protein of unknown function DUF16 Aminotran_1_2 PF00155.21 CCL99347.1 - 1e-63 215.7 0.0 1.1e-61 209.1 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class I and II ATPase_2 PF01637.18 CCL99349.1 - 3.8e-14 53.2 0.0 3e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea AAA_16 PF13191.6 CCL99349.1 - 2e-06 28.3 0.1 9e-06 26.2 0.0 2.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CCL99349.1 - 0.00085 19.6 0.0 0.41 10.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 CCL99349.1 - 0.06 13.8 0.0 9.6 6.6 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CCL99349.1 - 0.094 12.6 0.0 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase Piwi PF02171.17 CCL99350.1 - 1.7e-82 277.0 0.0 2.3e-82 276.6 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CCL99350.1 - 9.5e-22 78.1 0.1 2e-21 77.0 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CCL99350.1 - 4.9e-20 70.9 0.1 1.3e-19 69.6 0.1 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 CCL99350.1 - 2.6e-16 59.7 0.1 4.6e-16 58.9 0.1 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 CCL99350.1 - 2.3e-14 53.4 0.2 7.4e-14 51.8 0.0 2.0 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoMid PF16487.5 CCL99350.1 - 0.00041 20.6 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 Mid domain of argonaute ZapA PF05164.13 CCL99350.1 - 0.06 13.8 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 Cell division protein ZapA Abhydrolase_1 PF00561.20 CCL99351.1 - 3.7e-20 72.7 0.2 2.3e-14 53.7 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL99351.1 - 4.4e-14 53.6 0.1 6.2e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 CCL99351.1 - 7.4e-06 24.9 0.0 0.01 14.5 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 CCL99351.1 - 8.9e-05 21.9 0.0 0.0072 15.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 AAA_11 PF13086.6 CCL99352.1 - 2.9e-61 207.6 0.1 7.4e-61 206.2 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 CCL99352.1 - 5.6e-48 163.2 0.0 8.4e-48 162.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCL99352.1 - 8.4e-11 41.9 0.1 5.5e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCL99352.1 - 4.4e-09 36.8 0.0 1.6e-08 35.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCL99352.1 - 1.2e-07 31.7 0.2 0.25 11.1 0.0 3.5 3 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CCL99352.1 - 4.1e-05 23.9 0.2 0.0027 18.0 0.2 2.8 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 CCL99352.1 - 0.00019 21.5 0.0 0.053 13.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CCL99352.1 - 0.002 17.4 0.0 0.8 8.9 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 CCL99352.1 - 0.0024 17.4 0.0 0.45 9.9 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein AAA PF00004.29 CCL99352.1 - 0.0057 17.1 0.5 0.064 13.7 0.0 3.0 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCL99352.1 - 0.0063 16.9 0.3 0.035 14.5 0.3 2.3 1 1 0 1 1 1 1 AAA ATPase domain UvrD-helicase PF00580.21 CCL99352.1 - 0.012 15.1 0.0 0.098 12.2 0.0 2.1 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 CCL99352.1 - 0.012 14.8 0.0 0.93 8.6 0.0 2.4 2 0 0 2 2 2 0 PIF1-like helicase AAA_24 PF13479.6 CCL99352.1 - 0.033 13.9 0.0 2.3 7.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain HSP20 PF00011.21 CCL99353.1 - 1.4e-13 50.9 0.0 6e-07 29.6 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCL99353.1 - 1.5e-10 40.4 0.0 1.5e-09 37.3 0.0 2.2 1 1 0 1 1 1 1 HSP20-like domain found in ArsA CSTF2_hinge PF14327.6 CCL99354.1 - 1.1e-27 96.3 1.5 1.1e-27 96.3 1.5 1.7 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 ApbA PF02558.16 CCL99355.1 - 7.1e-18 64.7 0.0 1.5e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CCL99355.1 - 6.5e-17 61.9 0.0 3.4e-14 53.1 0.0 2.3 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA C terminal Abhydrolase_1 PF00561.20 CCL99356.1 - 1.2e-24 87.4 0.2 3.7e-24 85.8 0.2 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL99356.1 - 1.4e-16 61.8 0.4 2.1e-16 61.2 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL99356.1 - 1.2e-06 28.0 0.0 1.6e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CCL99356.1 - 0.21 10.3 0.0 0.32 9.7 0.0 1.2 1 0 0 1 1 1 0 Ndr family Abhydrolase_1 PF00561.20 CCL99357.1 - 8.9e-26 91.1 0.3 8.3e-25 87.9 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL99357.1 - 4.7e-16 60.0 0.1 6.6e-16 59.6 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL99357.1 - 5.6e-08 32.3 0.0 9.8e-08 31.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 AXE1 PF05448.12 CCL99357.1 - 0.0051 15.5 0.0 0.013 14.2 0.0 1.7 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) DUF722 PF05263.11 CCL99357.1 - 0.22 11.8 0.0 0.36 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF722) Abhydrolase_1 PF00561.20 CCL99358.1 - 1.7e-12 47.5 0.5 5.5e-09 36.0 0.1 3.0 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL99358.1 - 3e-10 41.1 2.6 4.1e-07 30.8 0.3 2.3 2 1 0 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL99358.1 - 0.03 13.6 0.0 0.13 11.5 0.0 2.0 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Ribonucleas_3_3 PF14622.6 CCL99360.1 - 1.1e-17 64.4 0.0 1.6e-16 60.6 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CCL99360.1 - 0.0041 17.7 0.0 0.0071 17.0 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease III domain Fungal_trans PF04082.18 CCL99361.1 - 1.8e-17 63.2 0.0 3.8e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Yae1_N PF09811.9 CCL99362.1 - 0.0019 17.8 0.7 0.0045 16.7 0.7 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Macoilin PF09726.9 CCL99362.1 - 7.2 5.0 16.2 13 4.2 16.2 1.3 1 0 0 1 1 1 0 Macoilin family Exo_endo_phos PF03372.23 CCL99363.1 - 8.7e-09 35.2 0.1 1.2e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4635 PF15466.6 CCL99363.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Ribosomal_L27e PF01777.18 CCL99364.1 - 4.6e-34 116.6 1.1 6.9e-34 116.1 1.1 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family FAD_binding_4 PF01565.23 CCL99364.1 - 7.6e-17 61.3 2.1 1.3e-16 60.6 2.1 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCL99364.1 - 3e-07 30.4 0.1 6.4e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like KOW PF00467.29 CCL99364.1 - 0.056 13.4 0.2 0.14 12.1 0.2 1.7 1 0 0 1 1 1 0 KOW motif BTB PF00651.31 CCL99365.1 - 1e-07 32.1 0.0 2e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 CCL99366.1 - 2.7e-10 40.4 0.0 7.6e-10 39.0 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain RhoGAP PF00620.27 CCL99367.1 - 1.7e-14 53.9 0.1 4.6e-14 52.5 0.1 1.8 1 0 0 1 1 1 1 RhoGAP domain BTB PF00651.31 CCL99367.1 - 2.4e-06 27.8 0.0 5.8e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain PapD-like PF14874.6 CCL99367.1 - 0.095 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Flagellar-associated PapD-like Exo_endo_phos PF03372.23 CCL99367.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.6 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Pro_isomerase PF00160.21 CCL99368.1 - 1.2e-47 162.1 0.0 3.1e-47 160.8 0.0 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 CCL99368.1 - 0.12 12.5 4.4 3.7 7.9 0.9 3.1 2 1 2 4 4 4 0 Tetratricopeptide repeat Phage_Mu_Gp45 PF06890.12 CCL99368.1 - 0.18 11.6 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage Mu Gp45 protein TPR_1 PF00515.28 CCL99368.1 - 0.39 10.6 3.1 12 5.9 0.2 2.9 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCL99368.1 - 0.98 10.1 7.4 2.3 8.9 5.6 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat F-box-like PF12937.7 CCL99370.1 - 0.00023 21.0 1.8 0.00066 19.5 1.8 1.8 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 CCL99370.1 - 0.041 13.5 0.5 0.15 11.6 0.5 2.0 1 1 0 1 1 1 0 F-box Rax2 PF12768.7 CCL99370.1 - 0.09 12.2 0.2 0.17 11.3 0.2 1.4 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF373 PF04123.13 CCL99370.1 - 0.21 11.0 6.7 0.51 9.7 6.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF373) AMP-binding PF00501.28 CCL99371.1 - 5.6e-85 285.5 2.5 6.4e-85 285.3 0.5 2.0 2 1 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCL99371.1 - 2.4e-25 89.3 0.2 6.5e-25 87.9 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CCL99371.1 - 5e-14 52.0 0.5 1.6e-13 50.3 0.3 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Crp PF00325.20 CCL99371.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family DUF2461 PF09365.10 CCL99372.1 - 4.4e-53 180.3 0.7 3.6e-52 177.4 0.0 2.5 2 1 0 2 2 2 1 Conserved hypothetical protein (DUF2461) CDC27 PF09507.10 CCL99372.1 - 0.37 10.1 23.1 0.51 9.7 23.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Suf PF05843.14 CCL99372.1 - 1.1 9.1 5.6 1.7 8.6 5.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Dsh_C PF12316.8 CCL99372.1 - 3.4 8.0 10.6 6.5 7.1 10.6 1.5 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Peroxin-3 PF04882.12 CCL99374.1 - 2.8e-144 481.6 0.1 3.4e-144 481.4 0.1 1.1 1 0 0 1 1 1 1 Peroxin-3 GFO_IDH_MocA PF01408.22 CCL99375.1 - 1.3e-14 55.0 0.0 2.5e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCL99375.1 - 1.9e-05 24.6 0.0 2.9e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Glyco_hydro_1 PF00232.18 CCL99376.1 - 1.1e-129 432.8 0.0 1.5e-129 432.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Zn_clus PF00172.18 CCL99377.1 - 1.9e-05 24.7 9.2 3.4e-05 23.9 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 CCL99377.1 - 0.032 14.2 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 PAS fold PI-PLC-X PF00388.19 CCL99378.1 - 4.2e-55 185.3 0.0 8.3e-55 184.4 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CCL99378.1 - 1.5e-42 144.6 0.0 3.2e-42 143.5 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_7 PF13499.6 CCL99378.1 - 7.8e-08 32.7 5.3 9.3e-05 22.8 0.2 2.7 1 1 1 2 2 2 2 EF-hand domain pair C2 PF00168.30 CCL99378.1 - 2.1e-05 24.8 0.0 0.0011 19.2 0.0 2.7 1 1 0 1 1 1 1 C2 domain PH_14 PF17787.1 CCL99378.1 - 0.0001 22.2 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_like PF09279.11 CCL99378.1 - 0.00037 20.9 0.0 0.24 11.9 0.0 2.8 2 0 0 2 2 2 2 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.32 CCL99378.1 - 0.012 15.1 0.1 0.24 11.0 0.0 2.8 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 CCL99378.1 - 0.15 12.0 1.3 3.5 7.8 0.2 3.3 4 0 0 4 4 4 0 EF-hand domain Mito_fiss_reg PF05308.11 CCL99379.1 - 0.046 13.8 0.2 0.046 13.8 0.2 2.2 1 1 2 3 3 3 0 Mitochondrial fission regulator DUF2205 PF10224.9 CCL99379.1 - 0.16 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Short coiled-coil protein Sdh_cyt PF01127.22 CCL99380.1 - 1e-24 86.9 1.6 1.2e-24 86.6 1.6 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PIF1 PF05970.14 CCL99381.1 - 5.7e-51 173.8 1.5 4.6e-43 147.8 0.2 2.7 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 CCL99381.1 - 3.9e-24 85.4 0.0 6.7e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCL99381.1 - 1.9e-13 51.0 0.1 3.7e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCL99381.1 - 5.1e-07 30.1 0.0 1.3e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 CCL99381.1 - 6.7e-05 21.0 0.1 0.0029 15.6 0.0 2.1 2 0 0 2 2 2 1 Helicase Viral_helicase1 PF01443.18 CCL99381.1 - 0.00012 21.9 0.3 0.046 13.5 0.1 3.0 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 CCL99381.1 - 0.00025 20.6 0.2 0.00051 19.6 0.2 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 CCL99381.1 - 0.00027 21.4 0.4 0.0016 18.9 0.1 2.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_11 PF13086.6 CCL99381.1 - 0.00051 19.9 0.1 0.1 12.4 0.0 2.6 1 1 1 2 2 2 1 AAA domain PhoH PF02562.16 CCL99381.1 - 0.00055 19.4 0.2 0.0011 18.4 0.2 1.5 1 0 0 1 1 1 1 PhoH-like protein T2SSE PF00437.20 CCL99381.1 - 0.00093 18.3 0.4 0.002 17.2 0.1 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein Mg_chelatase PF01078.21 CCL99381.1 - 0.0015 17.9 0.1 0.0025 17.2 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI UvrD_C_2 PF13538.6 CCL99381.1 - 0.002 17.9 0.1 0.0052 16.6 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA PF00004.29 CCL99381.1 - 0.0024 18.3 0.1 0.0062 17.0 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CCL99381.1 - 0.0032 17.4 0.7 0.0093 15.9 0.1 2.0 2 0 0 2 2 2 1 NACHT domain ABC_tran PF00005.27 CCL99381.1 - 0.005 17.4 0.2 0.019 15.5 0.1 1.8 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CCL99381.1 - 0.0088 15.8 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 CCL99381.1 - 0.0098 15.9 0.1 0.03 14.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 CCL99381.1 - 0.012 14.8 0.1 0.024 13.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CCL99381.1 - 0.014 15.1 0.1 0.032 13.9 0.1 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain MeaB PF03308.16 CCL99381.1 - 0.017 14.1 0.1 0.028 13.4 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 CCL99381.1 - 0.029 13.6 0.0 0.051 12.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RsgA_GTPase PF03193.16 CCL99381.1 - 0.057 13.3 0.1 0.18 11.7 0.2 1.8 2 0 0 2 2 1 0 RsgA GTPase TrwB_AAD_bind PF10412.9 CCL99381.1 - 0.061 12.2 0.2 0.11 11.4 0.2 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 CCL99381.1 - 0.07 12.5 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 CCL99381.1 - 0.084 13.3 0.1 0.21 12.0 0.1 1.8 1 1 0 1 1 1 0 RNA helicase Helicase_RecD PF05127.14 CCL99381.1 - 0.096 12.5 0.3 0.3 10.9 0.3 1.8 1 1 0 1 1 1 0 Helicase ATPase_2 PF01637.18 CCL99381.1 - 0.099 12.5 0.1 0.41 10.5 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 CCL99381.1 - 0.12 11.9 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CCL99381.1 - 0.12 12.3 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 CCL99381.1 - 0.26 10.7 0.8 0.43 10.1 0.8 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain BTHB PF18410.1 CCL99382.1 - 0.066 13.0 0.5 0.1 12.4 0.5 1.4 1 0 0 1 1 1 0 Basic tilted helix bundle domain UvdE PF03851.14 CCL99383.1 - 6.1e-89 297.9 0.0 1.2e-88 297.0 0.0 1.5 1 0 0 1 1 1 1 UV-endonuclease UvdE Thaumatin PF00314.17 CCL99385.1 - 8.9e-69 231.4 11.6 1.1e-68 231.1 11.6 1.1 1 0 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 CCL99385.1 - 0.14 11.4 1.0 0.15 11.3 0.0 1.5 2 0 0 2 2 2 0 Beta-1,3-glucanase Thaumatin PF00314.17 CCL99386.1 - 8.6e-69 231.4 11.2 1.1e-68 231.1 11.2 1.1 1 0 0 1 1 1 1 Thaumatin family Sof1 PF04158.14 CCL99389.1 - 7.9e-29 99.8 11.8 1.7e-28 98.7 11.8 1.6 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 CCL99389.1 - 2e-23 82.2 9.7 2e-08 34.7 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL99389.1 - 4.5e-08 33.3 0.2 0.73 10.2 0.0 4.3 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCL99389.1 - 0.013 15.4 0.0 0.098 12.5 0.0 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A CRC_subunit PF08624.10 CCL99390.1 - 2.9e-45 154.0 0.1 4.4e-45 153.4 0.1 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Sds3 PF08598.11 CCL99391.1 - 2.9e-27 96.1 3.1 2.9e-27 96.1 3.1 2.3 2 1 0 2 2 2 1 Sds3-like F-box-like PF12937.7 CCL99392.1 - 0.0046 16.8 0.0 0.093 12.6 0.0 2.8 2 0 0 2 2 2 1 F-box-like GST_N_2 PF13409.6 CCL99397.1 - 6e-15 55.3 0.0 1.6e-14 53.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCL99397.1 - 8.4e-13 48.5 0.0 1.5e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCL99397.1 - 1.3e-06 28.3 0.2 3.5e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCL99397.1 - 0.013 15.9 0.0 0.03 14.7 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 CCL99397.1 - 0.014 16.0 0.0 0.032 14.8 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CCL99397.1 - 0.16 12.7 0.0 0.63 10.8 0.0 1.9 1 1 1 2 2 2 0 Glutathione S-transferase N-terminal domain Hist_deacetyl PF00850.19 CCL99398.1 - 1.6e-50 172.4 0.0 2.6e-47 161.8 0.0 2.0 1 1 0 1 1 1 1 Histone deacetylase domain Amidase PF01425.21 CCL99399.1 - 6.8e-93 312.1 0.0 8.2e-93 311.8 0.0 1.1 1 0 0 1 1 1 1 Amidase Transp_cyt_pur PF02133.15 CCL99400.1 - 1.9e-15 56.6 14.5 2.5e-15 56.2 14.5 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin LapA_dom PF06305.11 CCL99400.1 - 1.8 8.4 7.6 5.5 6.9 0.2 3.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Sedlin_N PF04628.13 CCL99401.1 - 1.2e-17 64.2 0.0 1.6e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Cyt-b5 PF00173.28 CCL99402.1 - 6.8e-22 77.4 0.0 1.1e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DDHD PF02862.17 CCL99404.1 - 0.15 12.2 2.6 0.28 11.3 2.6 1.5 1 0 0 1 1 1 0 DDHD domain PID_2 PF14719.6 CCL99404.1 - 0.77 9.6 2.7 1.4 8.8 2.7 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF1682 PF07946.14 CCL99404.1 - 0.84 8.8 9.0 1.4 8.1 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Fmp27_WPPW PF10359.9 CCL99404.1 - 0.98 8.2 11.1 1.6 7.5 11.1 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain LCD1 PF09798.9 CCL99404.1 - 1.7 7.1 7.3 2.5 6.5 7.3 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Exonuc_VII_L PF02601.15 CCL99404.1 - 4.5 6.8 8.1 8.3 5.9 8.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HIG_1_N PF04588.13 CCL99405.1 - 0.00019 21.6 0.9 0.00019 21.6 0.9 2.2 2 0 0 2 2 2 1 Hypoxia induced protein conserved region Sensor PF13796.6 CCL99405.1 - 1.1 9.3 9.5 2.3 8.2 7.3 2.6 2 1 0 2 2 2 0 Putative sensor Ofd1_CTDD PF10637.9 CCL99406.1 - 7.7e-78 261.4 0.0 2.9e-76 256.2 0.0 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 CCL99406.1 - 1.2e-29 102.8 0.0 4.3e-29 101.0 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 CCL99406.1 - 5.8e-14 52.7 0.0 1.4e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_1 PF00076.22 CCL99407.1 - 2.2e-18 65.8 0.0 6.6e-09 35.5 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCL99407.1 - 0.014 15.4 0.0 0.034 14.2 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 CCL99407.1 - 0.076 12.8 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain AAA PF00004.29 CCL99408.1 - 5.9e-21 75.3 0.0 1.3e-20 74.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCL99408.1 - 0.0081 16.6 0.2 1.8 8.9 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain Mltc_N PF11873.8 CCL99408.1 - 0.016 14.9 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Membrane-bound lytic murein transglycosylase C, N-terminal domain AAA_19 PF13245.6 CCL99408.1 - 0.042 14.2 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCL99408.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 CCL99408.1 - 0.22 11.0 0.0 0.39 10.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HIG_1_N PF04588.13 CCL99409.1 - 1e-06 28.9 5.6 1.4e-06 28.4 4.5 1.8 2 0 0 2 2 2 1 Hypoxia induced protein conserved region DUF2162 PF09930.9 CCL99409.1 - 0.035 13.5 0.0 0.066 12.6 0.0 1.5 2 0 0 2 2 2 0 Predicted transporter (DUF2162) UQ_con PF00179.26 CCL99410.1 - 1.9e-13 50.2 0.1 2.9e-13 49.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCL99410.1 - 0.0073 16.6 0.0 0.009 16.3 0.0 1.4 1 0 0 1 1 1 1 RWD domain His_Phos_2 PF00328.22 CCL99411.1 - 1.7e-86 291.0 0.0 1.3e-85 288.1 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 CCL99411.1 - 4.1e-32 110.2 1.1 4.2e-20 71.7 0.2 2.5 2 0 0 2 2 2 2 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 CCL99411.1 - 1.7e-05 24.5 0.0 2.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain E1-E2_ATPase PF00122.20 CCL99412.1 - 1.9e-46 157.8 0.1 5.5e-46 156.4 0.1 1.8 1 0 0 1 1 1 1 E1-E2 ATPase HMA PF00403.26 CCL99412.1 - 1e-36 125.2 7.4 2.9e-13 50.0 0.0 5.0 4 1 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 CCL99412.1 - 4.3e-36 125.2 0.4 1.1e-35 123.9 0.4 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCL99412.1 - 2.8e-05 24.6 0.0 8.7e-05 23.0 0.0 1.9 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCL99412.1 - 0.0015 18.3 0.3 0.0042 16.9 0.1 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase GCP_N_terminal PF17681.1 CCL99413.1 - 1.1e-96 324.0 0.0 2.5e-96 322.9 0.0 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCL99413.1 - 7.6e-93 311.3 1.2 7.6e-93 311.3 1.2 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal PAXNEB PF05625.11 CCL99413.1 - 0.023 13.9 0.5 0.038 13.1 0.5 1.2 1 0 0 1 1 1 0 PAXNEB protein RE_HaeII PF09554.10 CCL99413.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 HaeII restriction endonuclease RasGAP_C PF03836.15 CCL99414.1 - 3.6e-45 153.5 2.8 1.3e-44 151.7 2.8 2.0 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.19 CCL99414.1 - 2.5e-41 141.7 0.4 7.9e-41 140.1 0.0 2.0 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase IQ PF00612.27 CCL99414.1 - 2.7e-13 48.5 63.9 0.0031 17.2 0.3 14.3 14 0 0 14 14 14 8 IQ calmodulin-binding motif CH PF00307.31 CCL99414.1 - 2.9e-09 37.1 0.0 7.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain Sipho_Gp157 PF05565.11 CCL99414.1 - 0.0039 17.2 0.5 0.013 15.5 0.5 1.8 1 0 0 1 1 1 1 Siphovirus Gp157 UCMA PF17085.5 CCL99414.1 - 0.017 15.1 3.3 0.089 12.8 3.3 2.2 1 0 0 1 1 1 0 Unique cartilage matrix associated protein Glyco_hydro_43 PF04616.14 CCL99415.1 - 5.1e-11 42.4 0.8 8.4e-11 41.7 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Peroxidase_2 PF01328.17 CCL99416.1 - 8.2e-50 169.9 0.0 1e-49 169.7 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 FF PF01846.19 CCL99417.1 - 1e-36 124.8 17.5 2.7e-10 40.3 0.0 5.9 6 0 0 6 6 6 5 FF domain WW PF00397.26 CCL99417.1 - 3.4e-11 43.0 19.9 1.9e-10 40.7 2.5 3.5 3 0 0 3 3 3 2 WW domain RhoGAP-FF1 PF16512.5 CCL99417.1 - 9.8e-08 32.6 3.4 0.12 13.1 2.1 4.6 2 2 1 3 3 3 2 p190-A and -B Rho GAPs FF domain HSP90 PF00183.18 CCL99418.1 - 3.3e-139 465.1 2.3 4.3e-139 464.8 2.3 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 CCL99418.1 - 1.3e-08 34.8 0.0 3.4e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCL99418.1 - 2.8e-08 34.2 0.0 7.1e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kelch_4 PF13418.6 CCL99420.1 - 4.8e-13 48.9 13.5 0.011 15.7 0.0 6.7 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CCL99420.1 - 3.9e-09 36.6 14.8 0.016 15.5 0.0 5.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CCL99420.1 - 3.8e-05 23.6 7.3 2 8.5 0.1 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 CCL99420.1 - 5.1e-05 23.4 4.9 1.5 9.2 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 CCL99420.1 - 5.5e-05 22.7 7.0 0.28 10.8 0.4 4.7 5 0 0 5 5 5 2 Kelch motif zf-C2H2 PF00096.26 CCL99421.1 - 3.4e-07 30.3 14.4 3.6e-06 27.1 3.0 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCL99421.1 - 3e-05 24.5 16.0 0.0035 18.1 2.5 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCL99421.1 - 0.00055 20.3 1.2 0.00055 20.3 1.2 4.2 4 0 0 4 4 4 1 Zinc-finger double domain FOXP-CC PF16159.5 CCL99421.1 - 0.021 15.5 1.0 0.021 15.5 1.0 2.1 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 CCL99421.1 - 0.1 12.9 0.4 0.1 12.9 0.4 1.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF2180 PF09947.9 CCL99421.1 - 0.11 12.5 0.2 0.21 11.6 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) zf-C2H2_2 PF12756.7 CCL99421.1 - 8.4 6.8 8.9 16 5.9 0.8 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Cid2 PF09774.9 CCL99422.1 - 7.1e-19 68.8 5.6 3.5e-18 66.5 5.6 1.8 1 1 0 1 1 1 1 Caffeine-induced death protein 2 GILT PF03227.16 CCL99423.1 - 6.3e-16 58.5 0.2 1.1e-15 57.7 0.2 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Yos1 PF08571.10 CCL99424.1 - 1.7e-22 79.5 0.0 2.2e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Yos1-like VirE3 PF06661.11 CCL99424.1 - 0.12 11.6 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 VirE3 Ribosomal_L22 PF00237.19 CCL99425.1 - 2.4e-23 82.3 0.3 4.1e-23 81.6 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribophorin_I PF04597.14 CCL99426.1 - 2.5e-132 442.2 0.0 2.9e-132 442.0 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I BRCT_2 PF16589.5 CCL99427.1 - 1.3e-10 41.6 0.0 2.5e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CCL99427.1 - 3e-07 30.7 0.1 6.3e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 CCL99427.1 - 2.3e-06 27.4 0.2 7.6e-06 25.7 0.0 1.9 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 CCL99427.1 - 3e-05 24.2 0.1 5.9e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 CCL99427.1 - 0.0099 15.9 0.1 0.019 15.0 0.1 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Vps52 PF04129.12 CCL99428.1 - 5.7e-64 216.7 3.6 1.8e-44 152.4 0.2 3.0 2 1 0 2 2 2 2 Vps52 / Sac2 family Sec3_C PF09763.9 CCL99428.1 - 3.6e-08 32.3 0.0 0.00014 20.5 0.7 2.3 1 1 1 2 2 2 2 Exocyst complex component Sec3 HrpE PF06188.12 CCL99428.1 - 0.054 13.4 0.2 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 HrpE/YscL/FliH and V-type ATPase subunit E Cep57_MT_bd PF06657.13 CCL99428.1 - 0.13 12.8 3.9 2.8 8.5 0.9 2.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 SlyX PF04102.12 CCL99428.1 - 0.16 12.6 1.1 1.9 9.1 0.3 3.0 3 0 0 3 3 3 0 SlyX DUF4349 PF14257.6 CCL99428.1 - 0.16 11.4 3.9 2.6 7.5 0.2 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) JAB PF01398.21 CCL99430.1 - 2.9e-15 56.3 0.2 5.8e-15 55.3 0.2 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CCL99430.1 - 7.3e-14 52.1 2.1 8.4e-14 52.0 0.8 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function DUF5624 PF18538.1 CCL99430.1 - 0.024 14.7 0.1 0.048 13.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) Tail_spike_N PF18668.1 CCL99430.1 - 0.11 12.3 0.0 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain Ribosomal_S18 PF01084.20 CCL99432.1 - 6.8e-13 48.6 0.3 1.5e-12 47.5 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 PIGA PF08288.12 CCL99432.1 - 0.16 12.6 0.1 0.47 11.1 0.0 1.7 2 0 0 2 2 2 0 PIGA (GPI anchor biosynthesis) Pkinase PF00069.25 CCL99433.1 - 2.7e-60 204.0 0.0 5.5e-41 140.7 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99433.1 - 7.8e-28 97.5 0.0 9.4e-23 80.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 CCL99433.1 - 7.3e-14 51.9 0.0 1.3e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 CCL99433.1 - 7.6e-09 35.3 0.2 0.00075 18.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CCL99433.1 - 0.00056 19.9 0.3 0.003 17.5 0.1 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family PAS_9 PF13426.7 CCL99433.1 - 0.0029 17.8 0.0 0.012 15.9 0.0 2.1 1 0 0 1 1 1 1 PAS domain Kdo PF06293.14 CCL99433.1 - 0.0061 15.9 0.4 0.023 14.0 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCL99433.1 - 0.0072 15.3 0.8 0.011 14.7 0.0 1.7 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 CCL99433.1 - 0.0097 15.6 0.0 1.2 8.7 0.0 2.4 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 CNDH2_C PF16858.5 CCL99433.1 - 0.051 13.4 0.9 0.12 12.2 0.9 1.6 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Seadorna_VP7 PF07387.11 CCL99433.1 - 0.067 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 CCL99433.1 - 0.068 12.8 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 RIO1 family UIM PF02809.20 CCL99434.1 - 0.00038 20.2 5.5 0.00038 20.2 5.5 2.5 2 0 0 2 2 2 2 Ubiquitin interaction motif Suc_Fer-like PF06999.12 CCL99435.1 - 1.7e-49 168.3 0.0 2.2e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Pkinase PF00069.25 CCL99436.1 - 2.9e-65 220.3 0.0 3.8e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99436.1 - 3.6e-29 101.8 0.0 5e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCL99436.1 - 5.4e-19 68.6 0.1 5.4e-19 68.6 0.1 3.0 3 0 0 3 3 2 1 Protein kinase C terminal domain C2 PF00168.30 CCL99436.1 - 7.1e-10 39.1 0.0 2.7e-05 24.4 0.0 2.4 2 0 0 2 2 2 2 C2 domain Kinase-like PF14531.6 CCL99436.1 - 5.6e-07 29.1 0.0 1.8e-06 27.5 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCL99436.1 - 1.3e-05 24.4 0.0 2.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CCL99436.1 - 0.0034 17.1 0.1 0.26 10.9 0.1 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Tim17 PF02466.19 CCL99436.1 - 0.026 14.9 2.5 0.026 14.9 0.9 1.7 2 0 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family APH PF01636.23 CCL99436.1 - 0.055 13.4 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CCL99436.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1935 PF09149.10 CCL99436.1 - 0.11 12.9 0.0 0.44 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1935) Forkhead PF00250.18 CCL99437.1 - 1.5e-30 105.3 0.0 2.3e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Med18 PF09637.10 CCL99438.1 - 4.4e-07 30.0 0.0 5e-05 23.3 0.0 2.0 1 1 1 2 2 2 2 Med18 protein CIAPIN1 PF05093.13 CCL99440.1 - 1.7e-30 105.5 3.3 2.7e-30 104.8 3.3 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 CCL99440.1 - 9.7e-05 22.6 0.0 0.00015 22.0 0.0 1.3 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus NAD_binding_1 PF00175.21 CCL99441.1 - 4.8e-10 40.0 0.0 1.7e-09 38.3 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCL99441.1 - 2.5e-08 34.1 0.0 4.4e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCL99441.1 - 1.9e-05 24.8 0.0 5.9e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain zf-H2C2_2 PF13465.6 CCL99442.1 - 5.8e-05 23.3 13.1 0.0045 17.4 0.9 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 CCL99442.1 - 0.00013 22.2 0.2 0.00013 22.2 0.2 3.7 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCL99442.1 - 0.0039 17.5 3.0 0.012 15.9 2.5 2.2 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCL99442.1 - 0.011 16.5 20.3 0.047 14.5 0.1 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger ETS_PEA3_N PF04621.13 CCL99442.1 - 0.041 13.8 0.6 0.081 12.8 0.6 1.4 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain DUF2890 PF11081.8 CCL99442.1 - 0.074 13.2 1.3 0.66 10.1 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2890) zf-C2H2_11 PF16622.5 CCL99442.1 - 0.1 12.4 5.0 7 6.5 0.1 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type NPC1_N PF16414.5 CCL99443.1 - 2.7e-76 256.4 7.3 2.7e-76 256.4 7.3 2.6 2 1 0 2 2 2 1 Niemann-Pick C1 N terminus Patched PF02460.18 CCL99443.1 - 5e-68 230.0 11.7 1.7e-37 129.0 0.3 3.1 3 0 0 3 3 3 3 Patched family Sterol-sensing PF12349.8 CCL99443.1 - 8.8e-43 145.8 23.7 1.9e-24 86.2 0.2 3.9 4 0 0 4 4 4 2 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 CCL99443.1 - 9.7e-06 23.6 5.8 2.2e-05 22.4 5.4 1.7 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family Folate_rec PF03024.14 CCL99443.1 - 8.8e-05 22.4 0.7 0.00017 21.5 0.7 1.3 1 0 0 1 1 1 1 Folate receptor family MMPL PF03176.15 CCL99443.1 - 4.7 6.1 27.4 0.11 11.4 2.3 3.8 5 0 0 5 5 5 0 MMPL family RRM_1 PF00076.22 CCL99444.1 - 1.4e-12 47.2 0.0 2.1e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCL99444.1 - 2.5e-05 23.8 0.0 4.1e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Diphthamide_syn PF01866.17 CCL99445.1 - 4.5e-94 315.3 0.0 1.5e-55 188.8 0.0 2.7 2 1 0 2 2 2 2 Putative diphthamide synthesis protein DUF3402 PF11882.8 CCL99446.1 - 5.5e-86 289.5 4.4 9.2e-81 272.3 1.5 3.5 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 CCL99446.1 - 1.2e-77 261.0 0.0 1.8e-77 260.3 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein Cyclin PF08613.11 CCL99447.1 - 7.7e-05 23.1 0.0 0.00014 22.3 0.0 1.4 1 0 0 1 1 1 1 Cyclin ThiF PF00899.21 CCL99448.1 - 7.7e-111 369.3 0.0 2.3e-69 233.5 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 CCL99448.1 - 3.3e-89 299.1 0.1 5.3e-89 298.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 CCL99448.1 - 2.9e-34 117.1 0.2 6.6e-34 115.9 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 CCL99448.1 - 2.3e-31 108.4 0.3 5e-31 107.3 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 CCL99448.1 - 3.5e-25 88.0 0.3 9e-25 86.7 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Herpes_UL46 PF03387.14 CCL99448.1 - 0.14 10.8 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL46 protein Diphthami_syn_2 PF01902.17 CCL99449.1 - 6.9e-39 133.6 0.0 5.6e-31 107.8 0.0 2.5 3 0 0 3 3 3 2 Diphthamide synthase Ribonuc_L-PSP PF01042.21 CCL99449.1 - 4.2e-19 68.7 0.0 1.6e-08 34.6 0.0 3.1 2 1 1 3 3 3 2 Endoribonuclease L-PSP MFS_1 PF07690.16 CCL99450.1 - 8e-08 31.6 22.0 0.00022 20.3 6.2 3.2 2 2 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CCL99450.1 - 0.0039 16.1 0.0 0.072 11.9 0.0 2.6 1 1 0 1 1 1 1 MFS_1 like family Reticulon PF02453.17 CCL99450.1 - 0.74 9.8 9.2 0.86 9.6 0.0 3.4 3 0 0 3 3 3 0 Reticulon EF-1_beta_acid PF10587.9 CCL99450.1 - 3 8.4 6.6 0.31 11.5 1.2 2.3 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region DUF2198 PF09964.9 CCL99450.1 - 5.1 7.3 8.0 16 5.7 0.1 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2198) Ank_4 PF13637.6 CCL99451.1 - 4.8e-25 87.6 1.7 5.9e-13 49.1 0.1 4.6 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCL99451.1 - 4.9e-22 78.3 0.0 3.7e-15 56.3 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCL99451.1 - 9.3e-17 60.9 0.6 3.9e-09 36.6 0.2 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCL99451.1 - 1.6e-14 52.6 0.1 0.00015 21.9 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CCL99451.1 - 2.8e-13 49.6 0.0 3.1e-05 24.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Wtap PF17098.5 CCL99453.1 - 1.2e-16 61.0 2.4 3.2e-14 53.2 2.4 2.0 1 1 0 1 1 1 1 WTAP/Mum2p family PRKG1_interact PF15898.5 CCL99453.1 - 0.00049 21.0 0.2 0.00085 20.2 0.2 1.3 1 1 0 1 1 1 1 cGMP-dependent protein kinase interacting domain TMF_DNA_bd PF12329.8 CCL99453.1 - 0.0067 16.4 1.7 0.25 11.4 0.1 2.2 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding DUF4686 PF15742.5 CCL99453.1 - 0.02 14.1 0.5 0.076 12.1 0.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) ATG16 PF08614.11 CCL99453.1 - 0.022 15.0 1.2 3.5 7.8 0.2 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) MOZART2 PF12926.7 CCL99453.1 - 0.025 14.2 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated Lebercilin PF15619.6 CCL99453.1 - 0.08 12.6 1.8 6.6 6.3 0.1 2.4 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease PRA-PH PF01503.17 CCL99453.1 - 0.084 13.3 0.1 0.87 10.1 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase CASP_C PF08172.12 CCL99453.1 - 0.1 11.9 4.6 1.1 8.6 0.3 2.2 2 1 0 2 2 2 0 CASP C terminal WD40_alt PF14077.6 CCL99453.1 - 0.11 12.4 1.2 5.6 6.9 0.0 2.8 2 1 1 3 3 3 0 Alternative WD40 repeat motif bZIP_1 PF00170.21 CCL99453.1 - 0.15 12.2 2.4 0.38 10.9 0.4 2.2 2 1 0 2 2 2 0 bZIP transcription factor SIKE PF05769.11 CCL99453.1 - 0.16 11.9 1.3 3.3 7.6 0.1 2.1 2 0 0 2 2 2 0 SIKE family SlyX PF04102.12 CCL99453.1 - 0.17 12.5 3.8 1.6 9.4 0.3 2.7 2 1 0 2 2 2 0 SlyX Glyco_hydro_20 PF00728.22 CCL99454.1 - 7.4e-35 121.0 0.1 8.5e-35 120.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain TrkH PF02386.16 CCL99455.1 - 1.7e-85 287.4 5.9 3e-85 286.6 5.9 1.4 1 0 0 1 1 1 1 Cation transport protein WD40 PF00400.32 CCL99455.1 - 0.0022 18.8 0.9 14 6.7 0.0 5.6 6 0 0 6 6 6 1 WD domain, G-beta repeat Vps54 PF07928.12 CCL99455.1 - 0.026 14.9 0.2 0.066 13.6 0.2 1.6 1 0 0 1 1 1 0 Vps54-like protein DUF2613 PF11021.8 CCL99456.1 - 0.031 14.4 0.0 0.076 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) MIF4G PF02854.19 CCL99457.1 - 0.027 14.1 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 MIF4G domain Prenyltrans PF00432.21 CCL99458.1 - 3e-26 90.9 9.6 6e-08 32.3 0.6 5.2 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CCL99458.1 - 0.024 13.8 0.0 2.9 6.9 0.0 2.5 3 0 0 3 3 3 0 Squalene-hopene cyclase N-terminal domain TED_complement PF07678.14 CCL99458.1 - 0.15 11.1 0.1 1.8 7.5 0.1 2.2 1 1 0 2 2 2 0 A-macroglobulin TED domain DUF676 PF05057.14 CCL99459.1 - 0.0002 20.9 0.0 0.00036 20.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 CCL99459.1 - 0.0025 17.7 0.0 0.0036 17.2 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 CCL99459.1 - 0.012 15.3 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein FMO-like PF00743.19 CCL99460.1 - 1.2e-32 113.1 0.0 1.2e-21 76.8 0.0 2.9 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCL99460.1 - 4.9e-07 29.3 0.0 3.5e-06 26.5 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCL99460.1 - 5.1e-06 25.9 0.3 0.00011 21.5 0.1 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCL99460.1 - 3.4e-05 23.3 3.8 0.00015 21.1 0.2 2.8 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCL99460.1 - 0.003 17.7 0.9 0.017 15.3 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCL99460.1 - 0.018 15.1 0.0 0.018 15.1 0.0 3.4 4 1 0 4 4 4 0 FAD-NAD(P)-binding Thi4 PF01946.17 CCL99460.1 - 0.022 14.0 0.2 4.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Thi4 family DUF202 PF02656.15 CCL99461.1 - 3.3e-19 69.1 1.4 3.3e-19 69.1 1.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) CD34_antigen PF06365.12 CCL99461.1 - 0.074 12.6 0.2 0.13 11.9 0.2 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family 7TM_GPCR_Srw PF10324.9 CCL99461.1 - 0.1 11.9 0.1 0.1 11.9 0.1 1.8 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw VMA21 PF09446.10 CCL99461.1 - 0.25 11.5 5.3 0.63 10.2 2.2 2.2 1 1 1 2 2 2 0 VMA21-like domain TMEM43 PF07787.12 CCL99461.1 - 0.26 10.7 2.7 0.34 10.3 2.7 1.1 1 0 0 1 1 1 0 Transmembrane protein 43 DUF3784 PF12650.7 CCL99461.1 - 0.46 10.7 5.2 0.55 10.5 4.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) ETF PF01012.21 CCL99462.1 - 1.7e-44 151.9 0.5 2.3e-44 151.5 0.5 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Peptidase_M16 PF00675.20 CCL99463.1 - 1.9e-53 180.5 1.1 6.4e-53 178.7 0.5 2.2 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCL99463.1 - 1.6e-41 142.3 0.0 1.3e-39 136.2 0.0 2.6 3 0 0 3 3 3 1 Peptidase M16 inactive domain MTD PF01993.18 CCL99463.1 - 0.0048 16.3 0.0 0.44 9.8 0.0 2.3 1 1 1 2 2 2 2 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase adh_short PF00106.25 CCL99464.1 - 1.2e-46 158.7 0.0 1.4e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99464.1 - 1.4e-38 132.8 0.0 1.8e-38 132.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL99464.1 - 1.3e-09 38.3 0.0 2.8e-09 37.2 0.0 1.5 1 1 0 2 2 2 1 KR domain Epimerase PF01370.21 CCL99464.1 - 0.00025 20.6 0.0 0.0014 18.1 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCL99464.1 - 0.0018 18.2 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 CCL99464.1 - 0.0033 16.9 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.8 CCL99464.1 - 0.21 11.4 0.9 0.55 10.0 0.8 1.7 1 1 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Hydrolase_4 PF12146.8 CCL99465.1 - 4.2e-08 32.7 1.2 3.2e-05 23.3 0.3 2.4 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCL99465.1 - 2.2e-07 31.7 7.7 4e-07 30.9 7.3 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCL99465.1 - 1.2e-06 28.3 0.8 0.001 18.8 0.8 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCL99465.1 - 0.0017 17.9 0.0 0.0038 16.7 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Thioesterase PF00975.20 CCL99465.1 - 0.0078 16.3 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain FSH1 PF03959.13 CCL99465.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Lipase PF00151.19 CCL99465.1 - 0.18 11.1 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipase HCO3_cotransp PF00955.21 CCL99466.1 - 2.3e-74 251.0 4.5 2.6e-33 115.6 2.6 3.1 2 1 1 3 3 3 3 HCO3- transporter family Sulfate_transp PF00916.20 CCL99466.1 - 0.00091 18.1 6.1 0.0011 17.8 0.7 2.5 3 0 0 3 3 3 2 Sulfate permease family His_Phos_2 PF00328.22 CCL99467.1 - 0.00042 19.8 0.5 0.047 13.0 0.0 2.6 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 2) Iwr1 PF08574.10 CCL99468.1 - 5.1e-14 53.0 9.7 5.1e-14 53.0 9.7 1.9 2 0 0 2 2 2 1 Transcription factor Iwr1 NYN PF01936.18 CCL99468.1 - 0.00011 22.7 0.0 0.00027 21.5 0.0 1.6 1 0 0 1 1 1 1 NYN domain Tyrosinase PF00264.20 CCL99469.1 - 2.5e-42 145.7 3.4 3.9e-42 145.0 3.4 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 CCL99469.1 - 1.1e-23 84.2 0.0 6.1e-23 81.8 0.0 2.1 2 0 0 2 2 2 1 Tyosinase C-terminal domain S-methyl_trans PF02574.16 CCL99469.1 - 0.081 12.7 0.1 4.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Homocysteine S-methyltransferase PHY PF00360.20 CCL99470.1 - 6.3e-26 90.8 0.0 1.1e-25 90.0 0.0 1.4 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 CCL99470.1 - 4.6e-21 75.4 0.0 9.4e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCL99470.1 - 2.2e-18 66.5 0.0 5.5e-18 65.2 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain GAF PF01590.26 CCL99470.1 - 8.8e-14 52.3 0.1 5.7e-13 49.6 0.1 2.5 2 0 0 2 2 2 1 GAF domain HisKA PF00512.25 CCL99470.1 - 1.2e-11 44.5 1.9 3.6e-11 42.9 1.9 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.11 CCL99470.1 - 2.1e-09 38.0 0.1 1.1e-08 35.6 0.0 2.4 2 0 0 2 2 2 1 PAS fold OKR_DC_1_N PF03709.15 CCL99470.1 - 0.0028 17.9 0.0 0.007 16.6 0.0 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain HATPase_c_3 PF13589.6 CCL99470.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MFS_1 PF07690.16 CCL99471.1 - 1.9e-51 175.1 11.0 2.6e-51 174.6 11.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 CCL99471.1 - 2.4e-08 32.7 6.7 2e-07 29.7 2.9 3.2 1 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family BT1 PF03092.16 CCL99471.1 - 0.002 16.4 1.8 0.008 14.5 0.0 2.2 2 0 0 2 2 2 1 BT1 family DUF4131 PF13567.6 CCL99471.1 - 3.5 7.3 9.2 5.8 6.5 0.0 4.0 3 2 1 4 4 4 0 Domain of unknown function (DUF4131) 2-oxoacid_dh PF00198.23 CCL99472.1 - 6.7e-79 264.6 0.0 8.8e-79 264.2 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CCL99472.1 - 6.7e-15 54.7 0.0 1.4e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 CCL99472.1 - 0.0003 21.5 0.1 0.34 11.6 0.0 2.4 1 1 1 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CCL99472.1 - 0.0035 17.1 0.0 0.047 13.5 0.0 2.6 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 CCL99472.1 - 0.009 15.9 1.5 0.01 15.7 0.1 1.8 2 0 0 2 2 2 1 Glycine cleavage H-protein MFS_1 PF07690.16 CCL99473.1 - 2.9e-42 144.9 17.3 9.1e-23 80.7 8.2 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCL99473.1 - 6.7e-08 31.8 6.7 6.7e-08 31.8 6.7 3.7 3 1 0 3 3 3 2 Sugar (and other) transporter VIT1 PF01988.19 CCL99473.1 - 0.02 14.8 0.6 0.02 14.8 0.6 2.1 3 0 0 3 3 3 0 VIT family MFS_3 PF05977.13 CCL99473.1 - 1.6 7.0 16.6 1.8 6.8 6.7 2.4 3 0 0 3 3 3 0 Transmembrane secretion effector Velvet PF11754.8 CCL99474.1 - 6.1e-39 134.5 0.0 8.5e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 Velvet factor Fungal_trans PF04082.18 CCL99476.1 - 0.05 12.6 0.0 0.078 12.0 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF1180 PF06679.12 CCL99477.1 - 0.0053 17.2 0.0 0.0053 17.2 0.0 8.6 2 1 2 5 5 5 1 Protein of unknown function (DUF1180) JSRP PF15312.6 CCL99477.1 - 0.053 13.4 0.3 0.42 10.6 0.1 2.7 2 0 0 2 2 2 0 Junctional sarcoplasmic reticulum protein Ribosomal_L23eN PF03939.13 CCL99478.1 - 4e-24 84.6 9.4 1.3e-23 83.0 9.4 1.9 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 CCL99478.1 - 2.4e-16 59.9 2.9 2.4e-16 59.9 2.9 2.4 2 1 0 2 2 2 1 Ribosomal protein L23 DUF5451 PF17532.2 CCL99478.1 - 0.031 14.5 0.8 0.04 14.2 0.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5451) ABC_membrane PF00664.23 CCL99480.1 - 3.9e-10 39.8 0.1 3.9e-10 39.8 0.1 2.6 3 0 0 3 3 3 2 ABC transporter transmembrane region PALP PF00291.25 CCL99481.1 - 1.3e-07 31.4 0.0 1.5e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ATPgrasp_YheCD PF14398.6 CCL99481.1 - 0.17 11.1 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 YheC/D like ATP-grasp adh_short PF00106.25 CCL99482.1 - 2.1e-35 122.0 1.1 4.7e-24 84.9 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99482.1 - 1.1e-21 77.5 1.1 3.3e-13 49.7 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCL99482.1 - 0.00099 18.6 0.1 0.0015 18.1 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CCL99482.1 - 0.19 11.1 0.0 17 4.6 0.0 2.2 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) DUF4492 PF14899.6 CCL99483.1 - 0.12 12.3 0.0 24 4.9 0.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) DUF2730 PF10805.8 CCL99483.1 - 3.7 7.7 5.6 9.3 6.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Mem_trans PF03547.18 CCL99484.1 - 2.6e-26 92.0 1.3 5.3e-26 90.9 1.3 1.4 1 1 0 1 1 1 1 Membrane transport protein DAHP_synth_2 PF01474.16 CCL99486.1 - 1.2e-137 459.0 0.0 1.7e-137 458.5 0.0 1.1 1 0 0 1 1 1 1 Class-II DAHP synthetase family adh_short PF00106.25 CCL99486.1 - 9.4e-23 80.7 0.0 3e-22 79.1 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99486.1 - 1.3e-15 57.6 0.0 2.3e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL99486.1 - 2.2e-08 34.3 0.1 3.4e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCL99486.1 - 0.00084 18.9 0.1 0.0013 18.3 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCL99486.1 - 0.011 14.9 0.1 0.022 13.9 0.0 1.4 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CCL99486.1 - 0.019 14.4 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCL99486.1 - 0.2 10.7 0.1 0.31 10.1 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain SUI1 PF01253.22 CCL99487.1 - 5e-22 78.2 0.7 5e-22 78.2 0.7 1.9 3 0 0 3 3 3 1 Translation initiation factor SUI1 FAD_binding_3 PF01494.19 CCL99488.1 - 6.7e-63 213.0 0.0 8.4e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Abhydrolase_6 PF12697.7 CCL99489.1 - 3.8e-11 44.0 0.2 4.9e-11 43.7 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL99489.1 - 7.4e-09 35.2 0.0 1.6e-08 34.1 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCL99489.1 - 9.9e-08 31.9 0.0 2.3e-07 30.8 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CCL99489.1 - 0.093 12.5 0.0 4 7.2 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Methyltransf_25 PF13649.6 CCL99490.1 - 4.3e-11 43.4 0.0 7.5e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCL99490.1 - 2.7e-08 34.4 0.0 4.2e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCL99490.1 - 1.5e-06 28.1 0.0 2.2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCL99490.1 - 8.1e-06 25.8 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCL99490.1 - 3.9e-05 23.1 0.0 0.00017 21.0 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CCL99490.1 - 0.00013 22.6 0.0 0.00021 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCL99490.1 - 0.16 11.2 0.0 0.29 10.4 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase NAD_binding_4 PF07993.12 CCL99492.1 - 8e-32 110.4 0.0 1.2e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CCL99492.1 - 3.2e-23 82.0 0.0 5e-22 78.1 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.21 CCL99492.1 - 5.4e-09 35.9 0.0 9e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCL99492.1 - 3.4e-07 30.5 0.0 7.5e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site ArdA PF07275.11 CCL99492.1 - 0.21 12.2 0.0 0.48 11.0 0.0 1.5 1 0 0 1 1 1 0 Antirestriction protein (ArdA) AMP-binding PF00501.28 CCL99493.1 - 1.7e-28 99.4 0.0 1.5e-27 96.3 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCL99493.1 - 5.2e-16 58.6 0.0 8.3e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 CCL99493.1 - 0.08 13.3 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Phosphopantetheine attachment site TPR_12 PF13424.6 CCL99493.1 - 0.22 11.9 0.1 2.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_28 PF00295.17 CCL99494.1 - 3e-57 194.2 20.1 3.3e-57 194.0 17.1 1.9 1 1 1 2 2 2 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CCL99494.1 - 1e-08 35.2 24.7 2.1e-08 34.2 17.7 2.6 2 1 0 2 2 2 2 Right handed beta helix region AcetylCoA_hyd_C PF13336.6 CCL99494.1 - 0.97 9.4 5.9 0.62 10.0 3.4 1.9 2 0 0 2 2 2 0 Acetyl-CoA hydrolase/transferase C-terminal domain Glyco_hydro_28 PF00295.17 CCL99495.1 - 9.7e-61 205.6 20.3 1.3e-60 205.2 20.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CCL99495.1 - 3.5e-09 36.7 22.0 1.3e-08 34.9 16.5 2.5 2 0 0 2 2 2 2 Right handed beta helix region DUF4957 PF16318.5 CCL99495.1 - 2.2 8.2 8.8 0.34 10.8 3.1 2.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4957) F-box PF00646.33 CCL99496.1 - 0.00016 21.5 0.0 0.00052 19.8 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCL99496.1 - 0.074 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 F-box-like p450 PF00067.22 CCL99497.1 - 3.2e-70 237.2 0.0 3.6e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 B12-binding PF02310.19 CCL99497.1 - 0.13 12.3 0.0 16 5.5 0.0 2.5 2 0 0 2 2 2 0 B12 binding domain Glycos_transf_2 PF00535.26 CCL99498.1 - 1.3e-24 86.9 0.0 1.7e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CCL99498.1 - 2.3e-11 44.0 0.1 4.6e-11 43.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CCL99498.1 - 0.0051 17.3 0.0 0.01 16.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CCL99498.1 - 0.0063 16.0 0.0 0.0097 15.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 F-box-like PF12937.7 CCL99501.1 - 0.005 16.7 0.1 0.014 15.3 0.1 1.8 1 0 0 1 1 1 1 F-box-like DAO PF01266.24 CCL99502.1 - 8.4e-40 137.4 1.0 9.7e-40 137.2 1.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCL99502.1 - 0.00072 19.7 0.1 0.0021 18.2 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCL99502.1 - 0.0027 17.0 0.1 0.005 16.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCL99502.1 - 0.051 12.8 0.0 0.085 12.1 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DHR10 PF18595.1 CCL99503.1 - 0.054 13.6 2.3 0.054 13.6 2.3 1.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF4589 PF15252.6 CCL99503.1 - 4.2 7.3 8.9 1.2 9.1 5.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4589) DUF1793 PF08760.11 CCL99504.1 - 2.2e-24 86.8 0.8 3.5e-24 86.1 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) PTP_tm PF18861.1 CCL99504.1 - 0.032 14.2 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J CbiM PF01891.16 CCL99504.1 - 1 9.2 4.5 0.35 10.7 1.1 1.9 2 0 0 2 2 2 0 Cobalt uptake substrate-specific transmembrane region Gram_pos_anchor PF00746.21 CCL99504.1 - 1.4 8.9 11.1 0.11 12.4 1.0 2.7 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Ribosomal_S11 PF00411.19 CCL99505.1 - 6.1e-47 158.6 1.6 8.2e-47 158.2 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 Acyltransferase PF01553.21 CCL99506.1 - 4.5e-14 52.2 0.0 7.4e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase zf-RING_5 PF14634.6 CCL99508.1 - 1.5e-08 34.5 11.9 3.4e-08 33.3 11.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCL99508.1 - 1.5e-07 31.6 12.2 3.6e-07 30.4 12.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCL99508.1 - 1.5e-06 27.9 9.9 3.2e-06 26.9 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCL99508.1 - 5e-06 26.4 6.5 5e-06 26.4 6.5 2.5 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CCL99508.1 - 8.5e-05 22.3 10.8 0.00019 21.2 10.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCL99508.1 - 0.00019 21.2 12.8 0.00043 20.1 12.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCL99508.1 - 0.00038 20.3 12.0 0.00082 19.2 12.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCL99508.1 - 0.00056 19.6 1.9 0.00056 19.6 1.9 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 CCL99508.1 - 0.0011 19.1 9.1 0.0033 17.5 9.1 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Rad50_zn_hook PF04423.14 CCL99508.1 - 0.0015 18.3 3.4 0.0039 17.0 3.4 1.7 1 0 0 1 1 1 1 Rad50 zinc hook motif zf-RING_4 PF14570.6 CCL99508.1 - 0.03 14.1 10.2 0.082 12.7 10.2 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain KxDL PF10241.9 CCL99508.1 - 0.031 14.6 4.1 0.075 13.3 4.1 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein TMEM192 PF14802.6 CCL99508.1 - 0.07 12.2 0.0 0.26 10.4 0.0 1.7 2 0 0 2 2 2 0 TMEM192 family DUF1272 PF06906.11 CCL99508.1 - 0.42 10.7 6.9 0.94 9.6 6.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-rbx1 PF12678.7 CCL99508.1 - 0.68 10.3 9.7 1.8 8.9 9.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Rtf2 PF04641.12 CCL99508.1 - 1.8 7.9 6.1 0.13 11.7 0.8 1.8 2 0 0 2 2 2 0 Rtf2 RING-finger Glycos_transf_2 PF00535.26 CCL99509.1 - 5.5e-31 107.7 0.0 7e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CCL99509.1 - 1.4e-08 34.9 0.0 2.5e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CCL99509.1 - 0.014 14.9 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CCL99509.1 - 0.017 14.6 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 Corona_M PF01635.18 CCL99509.1 - 0.051 12.9 0.3 0.29 10.4 0.0 1.9 2 0 0 2 2 2 0 Coronavirus M matrix/glycoprotein Synaptobrevin PF00957.21 CCL99510.1 - 4.7e-29 100.0 0.3 7.1e-29 99.4 0.3 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CCL99510.1 - 7.6e-25 86.8 0.0 1.5e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain YwcE PF17368.2 CCL99510.1 - 0.058 14.1 0.1 0.11 13.1 0.1 1.4 1 0 0 1 1 1 0 Spore morphogenesis and germination YwcE ClpB_D2-small PF10431.9 CCL99510.1 - 0.082 13.0 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 C-terminal, D2-small domain, of ClpB protein SLD3 PF08639.10 CCL99511.1 - 3.8e-15 55.7 27.7 5.7e-14 51.8 27.7 2.5 1 1 0 1 1 1 1 DNA replication regulator SLD3 Peptidase_S10 PF00450.22 CCL99512.1 - 1.4e-95 321.2 0.7 1.8e-95 320.8 0.7 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase F-box-like PF12937.7 CCL99512.1 - 0.065 13.1 1.0 0.19 11.6 1.0 1.8 1 0 0 1 1 1 0 F-box-like Hemerythrin PF01814.23 CCL99513.1 - 7.4e-07 29.9 0.1 1.3e-06 29.0 0.1 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF4276 PF14103.6 CCL99513.1 - 0.055 13.7 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4276) Fer2_3 PF13085.6 CCL99515.1 - 3.1e-33 114.0 0.1 4.5e-33 113.5 0.1 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 CCL99515.1 - 0.00067 20.2 0.1 0.00067 20.2 0.1 2.2 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer2 PF00111.27 CCL99515.1 - 0.0015 18.4 1.3 0.003 17.5 1.3 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 CCL99515.1 - 0.0046 17.4 3.6 0.015 15.7 3.6 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CCL99515.1 - 0.016 15.3 1.4 0.047 13.8 0.0 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Lung_7-TM_R PF06814.13 CCL99516.1 - 0.021 14.1 4.6 0.028 13.6 4.6 1.1 1 0 0 1 1 1 0 Lung seven transmembrane receptor COesterase PF00135.28 CCL99517.1 - 6.7e-10 38.4 0.1 8e-10 38.2 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family p450 PF00067.22 CCL99518.1 - 1.6e-72 244.7 0.0 4.2e-72 243.4 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCL99518.1 - 0.014 14.3 0.3 0.022 13.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) p450 PF00067.22 CCL99519.1 - 6.6e-71 239.4 0.0 2.1e-70 237.7 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCL99519.1 - 0.039 12.9 0.9 0.05 12.5 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4205) p450 PF00067.22 CCL99520.1 - 9.2e-66 222.5 0.0 3.6e-65 220.5 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 CCL99521.1 - 5.7e-42 143.9 0.0 4.1e-30 105.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99521.1 - 3.9e-27 95.2 0.0 3.9e-23 82.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Seadorna_VP7 PF07387.11 CCL99521.1 - 0.002 17.3 0.0 0.0029 16.7 0.0 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 CCL99521.1 - 0.0079 15.5 0.0 1.2 8.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CCL99521.1 - 0.012 15.6 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCL99521.1 - 0.018 13.8 1.2 0.024 13.4 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase RIO1 PF01163.22 CCL99521.1 - 0.035 13.7 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family p450 PF00067.22 CCL99522.1 - 1e-65 222.3 0.0 3.7e-65 220.5 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 PLDc_2 PF13091.6 CCL99523.1 - 3.5e-20 72.2 0.0 8.9e-14 51.5 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CCL99523.1 - 2e-05 24.6 0.4 0.059 13.6 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Mit_ribos_Mrp51 PF11709.8 CCL99527.1 - 3e-13 50.1 2.8 1.7e-12 47.7 2.8 1.8 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit Proteasome PF00227.26 CCL99528.1 - 1.9e-32 112.3 0.1 2.9e-32 111.7 0.1 1.3 1 1 0 1 1 1 1 Proteasome subunit Rot1 PF10681.9 CCL99529.1 - 5.9e-51 173.0 1.3 7e-51 172.7 1.3 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal DUF3300 PF11737.8 CCL99529.1 - 0.048 13.2 0.9 0.051 13.1 0.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3300) Aldo_ket_red PF00248.21 CCL99530.1 - 1.3e-45 155.9 0.0 8.6e-45 153.2 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family E3_binding PF02817.17 CCL99530.1 - 0.16 12.4 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 e3 binding domain HisG PF01634.18 CCL99531.1 - 1.4e-52 177.9 0.1 2e-52 177.4 0.1 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 CCL99531.1 - 4e-28 97.4 0.0 1.5e-27 95.6 0.0 2.0 3 0 0 3 3 3 1 HisG, C-terminal domain NMT1 PF09084.11 CCL99531.1 - 4.7e-05 23.4 0.1 6.8e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 NMT1/THI5 like Clat_adaptor_s PF01217.20 CCL99532.1 - 2.1e-52 176.9 4.9 1.1e-51 174.5 4.9 1.8 1 1 0 1 1 1 1 Clathrin adaptor complex small chain UQ_con PF00179.26 CCL99533.1 - 5e-43 146.1 0.0 6.2e-43 145.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 CCL99533.1 - 1.3e-19 69.8 0.2 2e-19 69.1 0.2 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 CCL99533.1 - 0.0026 17.5 0.0 0.0039 16.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UBA_6 PF18039.1 CCL99533.1 - 0.024 14.6 0.1 0.038 13.9 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain FeoA PF04023.14 CCL99533.1 - 0.028 14.6 0.0 0.051 13.8 0.0 1.3 1 0 0 1 1 1 0 FeoA domain ArfGap PF01412.18 CCL99534.1 - 9.4e-34 116.0 0.2 2.1e-33 114.9 0.2 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pkinase PF00069.25 CCL99535.1 - 4.6e-24 85.2 0.0 6.7e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99535.1 - 3.2e-11 43.0 0.0 5.9e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCL99535.1 - 7e-06 25.1 0.1 1.2e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCL99535.1 - 0.21 11.5 6.8 2 8.3 0.3 3.3 3 1 1 4 4 4 0 Phosphotransferase enzyme family Pribosyltran_N PF13793.6 CCL99537.1 - 7.9e-44 148.3 0.3 1.2e-42 144.5 0.1 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CCL99537.1 - 6.5e-40 137.1 0.8 2.6e-34 118.8 0.3 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CCL99537.1 - 1.8e-14 53.6 0.3 6.8e-14 51.7 0.2 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCL99537.1 - 0.085 12.3 0.1 0.16 11.4 0.1 1.5 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase DCP2 PF05026.13 CCL99538.1 - 1.3e-31 108.7 2.0 2.2e-31 108.0 2.0 1.4 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 CCL99538.1 - 4.7e-13 49.3 0.0 9.9e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain GNAT_acetyltr_2 PF13718.6 CCL99539.1 - 1.4e-89 299.4 0.0 2.9e-89 298.4 0.0 1.6 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 CCL99539.1 - 6e-87 291.2 0.2 1.3e-86 290.2 0.2 1.6 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 CCL99539.1 - 8.3e-64 214.7 0.0 8.3e-64 214.7 0.0 2.2 3 0 0 3 3 3 1 Helicase DUF1726 PF08351.11 CCL99539.1 - 1.4e-32 111.5 0.1 3.4e-32 110.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Rad21_Rec8_N PF04825.13 CCL99539.1 - 2.2e-21 76.1 0.0 5.3e-21 74.9 0.0 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein DUF3292 PF11696.8 CCL99539.1 - 9.1e-05 21.0 3.8 0.012 14.0 0.8 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3292) GRAM PF02893.20 CCL99539.1 - 0.048 13.5 0.0 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 GRAM domain NUDIX PF00293.28 CCL99540.1 - 6.8e-24 84.4 0.0 8.9e-24 84.0 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain YL1 PF05764.13 CCL99541.1 - 0.027 14.6 3.2 0.032 14.4 3.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 CCL99541.1 - 1.4 8.2 5.3 1.8 7.8 5.3 1.1 1 0 0 1 1 1 0 NOA36 protein SOG2 PF10428.9 CCL99541.1 - 1.9 7.6 11.4 1.8 7.6 11.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIF_alpha PF05793.12 CCL99541.1 - 2.3 6.7 9.8 2.8 6.4 9.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Apt1 PF10351.9 CCL99541.1 - 4.6 6.0 9.3 5.4 5.8 9.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF908 PF06012.12 CCL99543.1 - 4.6 6.5 8.5 6.9 6.0 8.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) MPC PF03650.13 CCL99544.1 - 2.5e-36 124.2 0.2 2.7e-36 124.0 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers DNA_ligase_A_M PF01068.21 CCL99545.1 - 5.1e-65 218.9 0.1 8.7e-65 218.2 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCL99545.1 - 1.6e-45 155.6 0.3 3.3e-45 154.5 0.3 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CCL99545.1 - 1.6e-26 92.8 0.0 4e-26 91.5 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 CCL99545.1 - 7.2e-05 23.2 0.0 0.00014 22.2 0.0 1.6 1 0 0 1 1 1 1 RNA ligase DNA_ligase_OB_2 PF14743.6 CCL99545.1 - 0.023 14.7 0.1 3.9 7.6 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain Salp15 PF12115.8 CCL99545.1 - 0.068 13.6 0.0 0.86 10.1 0.0 2.4 1 1 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation DUF4746 PF15928.5 CCL99545.1 - 0.19 11.1 7.7 0.17 11.2 6.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) Ricin_B_lectin PF00652.22 CCL99547.1 - 0.048 13.9 0.0 0.067 13.4 0.0 1.3 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain AIM24 PF01987.17 CCL99548.1 - 0.028 14.2 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial biogenesis AIM24 MetallophosC PF16370.5 CCL99548.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.8 1 1 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase PSDC PF12588.8 CCL99549.1 - 6.2e-51 172.0 0.0 1e-50 171.3 0.0 1.4 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.15 CCL99549.1 - 7.4e-37 126.8 0.0 9.9e-37 126.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase AA_permease_2 PF13520.6 CCL99550.1 - 1.3e-53 182.4 54.0 1.6e-53 182.1 54.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCL99550.1 - 6.2e-14 51.4 47.7 8.7e-14 51.0 47.7 1.1 1 0 0 1 1 1 1 Amino acid permease Patatin PF01734.22 CCL99550.1 - 0.23 11.6 3.3 0.65 10.1 0.5 2.3 2 0 0 2 2 2 0 Patatin-like phospholipase Abhydrolase_6 PF12697.7 CCL99552.1 - 5.5e-09 36.9 4.3 7.3e-09 36.6 4.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family AA_permease PF00324.21 CCL99553.1 - 2.7e-118 395.6 43.2 3.4e-118 395.3 43.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCL99553.1 - 3.9e-45 154.5 44.5 4.9e-45 154.1 44.5 1.1 1 0 0 1 1 1 1 Amino acid permease Oxidored_q4 PF00507.19 CCL99553.1 - 2.7 8.2 7.5 21 5.4 5.6 3.2 2 1 1 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 HET PF06985.11 CCL99554.1 - 1.6e-14 54.5 4.0 3.9e-13 50.0 0.1 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) AMH_N PF04709.12 CCL99554.1 - 0.12 11.3 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region GST_N PF02798.20 CCL99555.1 - 6.3e-18 64.9 0.4 5.1e-17 62.0 0.0 2.4 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCL99555.1 - 3.8e-14 52.7 0.1 7e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCL99555.1 - 1.9e-12 47.4 0.0 3.3e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCL99555.1 - 9.7e-12 45.0 0.0 2.4e-11 43.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCL99555.1 - 1.5e-09 37.9 0.1 2.7e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCL99555.1 - 0.00019 21.4 0.0 0.00043 20.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCL99556.1 - 3.8e-15 55.9 0.0 6.5e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCL99556.1 - 2.5e-11 43.8 0.0 4.2e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCL99556.1 - 5.7e-11 42.5 0.0 9.9e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCL99556.1 - 1.2e-10 41.5 0.1 1.1e-09 38.5 0.1 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCL99556.1 - 1.1e-08 35.2 0.1 2.9e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCL99556.1 - 9.3e-07 28.8 0.1 1.8e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCL99556.1 - 0.045 14.3 0.0 0.21 12.2 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF4131 PF13567.6 CCL99557.1 - 0.33 10.6 4.7 0.11 12.1 1.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 CCL99558.1 - 1.3e-27 96.7 25.4 2.8e-23 82.4 11.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 CCL99558.1 - 0.3 11.1 0.1 0.3 11.1 0.1 3.6 3 1 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3040 PF11239.8 CCL99558.1 - 0.41 10.9 4.4 0.58 10.5 0.3 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) DUF1516 PF07457.11 CCL99558.1 - 0.54 10.5 3.4 1.2 9.4 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) Peptidase_M41 PF01434.18 CCL99559.1 - 1e-62 211.4 0.1 2.3e-62 210.2 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 CCL99559.1 - 2.4e-42 144.5 0.0 4.5e-42 143.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.15 CCL99559.1 - 3.9e-13 49.7 0.2 1.1e-12 48.3 0.0 1.8 2 0 0 2 2 2 1 FtsH Extracellular AAA_lid_3 PF17862.1 CCL99559.1 - 4.7e-13 48.7 0.0 2e-12 46.7 0.1 2.0 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 CCL99559.1 - 0.0033 17.4 0.0 0.015 15.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) CHAD PF05235.14 CCL99559.1 - 0.0045 17.0 0.1 0.0095 15.9 0.1 1.5 1 0 0 1 1 1 1 CHAD domain RuvB_N PF05496.12 CCL99559.1 - 0.0053 16.5 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCL99559.1 - 0.0053 17.0 0.0 0.49 10.7 0.1 2.6 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 CCL99559.1 - 0.0057 15.9 0.0 0.01 15.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 CCL99559.1 - 0.0072 16.5 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CCL99559.1 - 0.011 16.1 0.1 0.08 13.3 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 CCL99559.1 - 0.036 14.5 0.4 0.18 12.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CCL99559.1 - 0.043 13.5 0.0 0.098 12.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein His_Phos_2 PF00328.22 CCL99560.1 - 1.7e-39 136.3 0.0 7.7e-39 134.1 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PP2C PF00481.21 CCL99561.1 - 4.9e-33 114.9 0.0 7.4e-32 111.0 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CCL99561.1 - 0.019 14.6 0.1 0.036 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein phosphatase 2C G_glu_transpept PF01019.21 CCL99562.1 - 2.9e-07 29.6 0.0 3.2e-07 29.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.21 CCL99563.1 - 3.8e-111 372.4 0.0 5.1e-111 371.9 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF2835 PF11197.8 CCL99563.1 - 0.091 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2835) Fungal_trans PF04082.18 CCL99564.1 - 0.0079 15.3 0.1 0.028 13.4 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CCL99565.1 - 3.2e-27 95.4 53.0 3.4e-25 88.7 41.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CCL99565.1 - 4e-05 23.1 29.9 0.00011 21.6 29.9 1.7 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Pam17 PF08566.10 CCL99565.1 - 0.2 11.5 0.5 0.46 10.3 0.5 1.6 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 TetR_C_16 PF17920.1 CCL99565.1 - 4 7.7 6.1 9.9 6.5 0.6 3.0 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain EXS PF03124.14 CCL99566.1 - 2.1e-81 273.8 29.7 2.6e-81 273.5 29.7 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 CCL99566.1 - 8.2e-51 174.1 0.1 1.3e-50 173.5 0.1 1.3 1 0 0 1 1 1 1 SPX domain RmlD_sub_bind PF04321.17 CCL99566.1 - 1e-32 113.4 0.0 1.6e-21 76.6 0.0 2.2 1 1 1 2 2 2 2 RmlD substrate binding domain Epimerase PF01370.21 CCL99566.1 - 7.9e-12 45.1 0.0 2.1e-09 37.2 0.0 2.3 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCL99566.1 - 0.024 14.1 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCL99566.1 - 0.17 11.0 0.0 3.5 6.7 0.0 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein LSM PF01423.22 CCL99568.1 - 1.5e-16 59.8 0.0 1.9e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 LSM domain Glyco_hydro_28 PF00295.17 CCL99569.1 - 2.9e-37 128.4 13.3 2.9e-35 121.9 13.3 2.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 TPT PF03151.16 CCL99570.1 - 3.2e-23 82.5 17.2 3.8e-23 82.3 17.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCL99570.1 - 0.013 15.7 9.8 0.013 15.7 9.8 2.2 2 0 0 2 2 2 0 EamA-like transporter family Glyco_hydro_28 PF00295.17 CCL99573.1 - 1.1e-53 182.4 7.8 1.4e-53 182.1 7.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 TENA_THI-4 PF03070.16 CCL99574.1 - 1.1e-09 38.4 0.0 1.5e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family FBPase_3 PF01950.16 CCL99574.1 - 0.16 11.1 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Fructose-1,6-bisphosphatase Sec2p PF06428.11 CCL99575.1 - 3e-14 52.7 9.9 3e-14 52.7 9.9 2.2 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF4200 PF13863.6 CCL99575.1 - 0.0016 18.8 7.1 0.013 15.8 5.9 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) Herpes_UL6 PF01763.16 CCL99575.1 - 0.071 11.6 5.0 0.098 11.2 1.1 2.1 1 1 0 2 2 2 0 Herpesvirus UL6 like Rab5-bind PF09311.11 CCL99575.1 - 0.071 12.5 14.5 0.12 11.8 14.5 1.2 1 0 0 1 1 1 0 Rabaptin-like protein FlxA PF14282.6 CCL99575.1 - 0.52 10.3 5.7 15 5.6 0.0 3.0 2 0 0 2 2 2 0 FlxA-like protein ATG16 PF08614.11 CCL99575.1 - 0.93 9.7 32.1 3.1 8.0 10.3 3.5 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) AAA_13 PF13166.6 CCL99575.1 - 3.4 6.2 10.9 4.2 5.9 6.7 1.9 1 1 0 1 1 1 0 AAA domain Spc7 PF08317.11 CCL99575.1 - 6.3 5.6 17.2 1.5 7.7 10.5 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 CCL99575.1 - 7.7 6.6 9.6 14 5.8 0.7 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) SIS PF01380.22 CCL99576.1 - 4.8e-64 214.1 0.2 4.3e-33 113.9 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CCL99576.1 - 2e-15 57.2 0.0 3.9e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CCL99576.1 - 3.6e-11 43.1 0.0 8.5e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CCL99576.1 - 0.00021 20.3 0.0 0.00034 19.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 CCL99576.1 - 0.088 12.8 0.0 0.59 10.2 0.0 2.2 1 1 1 2 2 2 0 SIS domain G-patch_2 PF12656.7 CCL99577.1 - 1.5e-23 82.6 0.1 4.7e-23 81.0 0.1 2.0 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 CCL99577.1 - 0.028 14.3 0.1 0.064 13.2 0.1 1.7 1 0 0 1 1 1 0 G-patch domain DUF485 PF04341.12 CCL99579.1 - 0.33 10.9 6.9 0.079 12.9 2.3 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 p450 PF00067.22 CCL99580.1 - 2.3e-64 217.8 0.0 9.6e-64 215.8 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 DUF805 PF05656.14 CCL99581.1 - 0.023 15.1 0.7 0.023 15.1 0.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF805) DUF1077 PF06417.12 CCL99581.1 - 1.6 8.8 9.4 0.51 10.4 0.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1077) MFS_1 PF07690.16 CCL99584.1 - 4.9e-14 52.0 52.1 1.3e-12 47.3 26.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CsbD PF05532.12 CCL99584.1 - 0.41 10.6 4.9 0.96 9.4 4.9 1.5 1 0 0 1 1 1 0 CsbD-like Sec23_trunk PF04811.15 CCL99585.1 - 5.6e-72 242.2 0.0 1.5e-71 240.8 0.0 1.7 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CCL99585.1 - 1.3e-22 79.5 0.4 4.5e-22 77.8 0.1 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CCL99585.1 - 5.9e-18 65.4 0.1 1.4e-17 64.2 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CCL99585.1 - 3.6e-16 58.9 7.5 7.2e-16 58.0 7.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CCL99585.1 - 4.5e-09 36.1 0.0 9.4e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat WW PF00397.26 CCL99585.1 - 1.5e-05 24.9 0.4 1.5e-05 24.9 0.4 1.8 2 0 0 2 2 2 1 WW domain Vps36-NZF-N PF16988.5 CCL99585.1 - 0.0098 15.3 0.7 0.02 14.3 0.7 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain ELYS PF13934.6 CCL99586.1 - 1.7e-44 152.4 0.1 2.9e-44 151.7 0.1 1.4 1 0 0 1 1 1 1 Nuclear pore complex assembly Ribosomal_S5_C PF03719.15 CCL99587.1 - 6.7e-20 70.3 0.0 1.4e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CCL99587.1 - 3.7e-17 62.0 0.3 8.5e-17 60.9 0.3 1.7 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain PITH PF06201.13 CCL99588.1 - 2.8e-34 118.5 0.0 3.4e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 PITH domain Pkinase PF00069.25 CCL99589.1 - 1.9e-51 174.9 0.0 2.6e-51 174.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99589.1 - 6.6e-32 110.8 0.0 9.3e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCL99589.1 - 0.00024 20.5 0.0 0.00073 18.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pox_ser-thr_kin PF05445.11 CCL99589.1 - 0.0035 16.4 0.1 0.0063 15.5 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 CCL99589.1 - 0.044 13.7 0.3 0.14 12.1 0.2 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family BPL_LplA_LipB PF03099.19 CCL99589.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family Transp_cyt_pur PF02133.15 CCL99590.1 - 2.4e-101 339.7 35.8 2.8e-101 339.5 35.8 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF4260 PF14079.6 CCL99590.1 - 8.1 6.5 11.9 6 6.9 3.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4260) ATP-synt_10 PF05176.14 CCL99591.1 - 2.9e-65 220.0 0.0 3.7e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein rve_3 PF13683.6 CCL99591.1 - 0.29 11.0 2.6 14 5.6 0.1 2.4 2 0 0 2 2 2 0 Integrase core domain WD40 PF00400.32 CCL99595.1 - 8.9e-46 152.9 10.8 9.3e-10 39.0 0.0 11.8 11 0 0 11 11 11 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL99595.1 - 7.8e-26 90.2 0.0 0.0044 17.3 0.0 10.1 4 2 6 11 11 11 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 CCL99595.1 - 4.3e-23 81.7 0.0 6.5e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 CCL99595.1 - 2.1e-10 40.1 3.1 0.19 10.7 0.0 6.8 3 3 5 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1513 PF07433.11 CCL99595.1 - 0.00047 19.3 0.1 3.4 6.7 0.0 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1513) Cytochrom_D1 PF02239.16 CCL99595.1 - 0.0012 17.5 0.2 4.5 5.7 0.0 3.7 4 0 0 4 4 4 2 Cytochrome D1 heme domain PQQ_2 PF13360.6 CCL99595.1 - 0.0021 17.7 0.8 0.041 13.4 0.1 3.1 3 1 1 4 4 4 1 PQQ-like domain Utp21 PF04192.12 CCL99595.1 - 0.004 16.7 0.0 0.0065 16.0 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ELYS-bb PF16687.5 CCL99595.1 - 0.0043 15.7 0.0 0.11 11.1 0.0 2.6 3 0 0 3 3 3 1 beta-propeller of ELYS nucleoporin SGL PF08450.12 CCL99595.1 - 0.0066 16.1 0.0 8.7 5.8 0.0 3.4 3 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 CCL99595.1 - 0.014 15.3 1.3 3.1 7.8 0.0 5.1 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat PH_6 PF15406.6 CCL99595.1 - 0.028 14.7 0.0 1.1 9.6 0.0 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain PALB2_WD40 PF16756.5 CCL99595.1 - 0.088 11.7 0.0 0.25 10.2 0.0 1.7 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain RAB3GAP2_N PF14655.6 CCL99595.1 - 0.11 11.7 1.0 1.4 8.1 0.0 3.2 5 1 1 6 6 6 0 Rab3 GTPase-activating protein regulatory subunit N-terminus OPT PF03169.15 CCL99596.1 - 3.6e-113 379.4 44.0 2.5e-112 376.6 44.0 1.8 1 1 0 1 1 1 1 OPT oligopeptide transporter protein OPT PF03169.15 CCL99597.1 - 4e-11 42.3 2.1 4.5e-11 42.1 2.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF5531 PF17671.1 CCL99597.1 - 0.82 9.5 4.9 0.2 11.6 1.8 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5531) Sugar_tr PF00083.24 CCL99598.1 - 7.4e-87 292.1 26.8 8.5e-87 291.9 26.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCL99598.1 - 3.7e-26 91.9 56.5 6.7e-25 87.7 29.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily AXIN1_TNKS_BD PF16646.5 CCL99599.1 - 0.043 14.7 0.7 0.072 14.0 0.7 1.4 1 0 0 1 1 1 0 Axin-1 tankyrase binding domain RRM_1 PF00076.22 CCL99601.1 - 3.9e-12 45.8 0.0 6.5e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 CCL99601.1 - 2.9e-06 27.7 0.3 8.3e-06 26.3 0.3 1.8 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 ATP_sub_h PF10775.9 CCL99601.1 - 0.052 13.5 0.4 0.19 11.8 0.2 2.1 2 0 0 2 2 2 0 ATP synthase complex subunit h HlyIII PF03006.20 CCL99603.1 - 8.3e-30 104.2 17.4 7.6e-16 58.5 2.4 2.1 2 0 0 2 2 2 2 Haemolysin-III related p450 PF00067.22 CCL99604.1 - 6.4e-31 107.6 0.0 3.3e-30 105.3 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 TPIP1 PF15338.6 CCL99604.1 - 0.048 13.7 0.1 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 p53-regulated apoptosis-inducing protein 1 Neugrin PF06413.11 CCL99605.1 - 2.9e-12 47.1 1.6 4.1e-12 46.6 1.6 1.3 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.7 CCL99605.1 - 0.0011 19.1 6.6 0.0011 19.1 6.6 1.6 1 1 1 2 2 2 1 Mitochondrial ribosomal protein subunit L20 Cofilin_ADF PF00241.20 CCL99606.1 - 1.3e-27 96.0 0.1 1.5e-27 95.8 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Acetyltransf_1 PF00583.25 CCL99607.1 - 8.4e-16 58.3 0.0 1e-15 58.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCL99607.1 - 1e-05 25.9 0.0 1.7e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CCL99607.1 - 0.00035 21.3 0.0 0.00048 20.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCL99607.1 - 0.0004 20.3 0.0 0.00052 20.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NAC PF01849.18 CCL99608.1 - 1.5e-18 66.5 0.6 4.4e-15 55.4 0.0 2.4 2 0 0 2 2 2 2 NAC domain WD40 PF00400.32 CCL99609.1 - 2.3e-26 91.5 30.5 1.8e-05 25.4 0.8 10.6 12 0 0 12 12 11 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL99609.1 - 3.6e-19 68.8 1.4 1.4e-08 34.9 0.0 5.6 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCL99609.1 - 3.3e-07 30.4 0.6 0.0044 16.9 0.0 3.7 3 2 2 5 5 5 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCL99609.1 - 4e-05 22.7 0.6 0.29 10.0 0.0 4.0 3 2 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 CCL99609.1 - 0.0007 19.0 1.2 1.7 7.9 0.0 3.3 3 0 0 3 3 3 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 CCL99609.1 - 0.0012 18.8 0.4 1.8 8.6 0.3 3.8 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 CCL99609.1 - 0.0063 14.6 0.1 0.038 12.0 0.0 1.9 2 0 0 2 2 2 1 IKI3 family RAB3GAP2_N PF14655.6 CCL99609.1 - 0.011 15.1 0.0 0.16 11.2 0.0 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Kelch_6 PF13964.6 CCL99609.1 - 0.025 14.9 0.1 1.2 9.5 0.0 3.3 3 0 0 3 3 3 0 Kelch motif Frtz PF11768.8 CCL99609.1 - 0.033 12.5 0.0 2.4 6.4 0.0 2.7 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Big_2 PF02368.18 CCL99609.1 - 5.3 7.0 7.6 14 5.7 0.1 4.3 4 1 1 5 5 5 0 Bacterial Ig-like domain (group 2) Mad3_BUB1_I PF08311.12 CCL99610.1 - 2.1e-36 124.6 0.0 3.3e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 ECH_1 PF00378.20 CCL99610.1 - 0.061 12.6 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Herpes_pp85 PF04637.12 CCL99610.1 - 0.31 9.4 2.1 0.45 8.9 2.1 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) MFS_1 PF07690.16 CCL99611.1 - 3.4e-29 101.9 32.0 3.4e-29 101.9 32.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily AlcCBM31 PF11606.8 CCL99611.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein RRM_1 PF00076.22 CCL99612.1 - 2.8e-31 107.1 0.0 9.5e-11 41.4 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CCL99612.1 - 7.6e-08 32.4 2.8 1.4e-05 25.1 0.0 3.0 3 0 0 3 3 3 2 Poly-adenylate binding protein, unique domain Sterol_MT_C PF08498.10 CCL99613.1 - 7.6e-27 93.4 0.0 1.2e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_31 PF13847.6 CCL99613.1 - 2.2e-17 63.2 0.0 3.4e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCL99613.1 - 6.1e-17 62.0 0.0 1e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCL99613.1 - 2.5e-15 56.9 0.0 5.2e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCL99613.1 - 5.9e-14 52.0 0.0 8.5e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 CCL99613.1 - 3.2e-10 40.6 0.2 6.2e-10 39.7 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCL99613.1 - 1.6e-09 37.9 0.0 2.3e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCL99613.1 - 1.5e-07 31.0 0.0 2.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CCL99613.1 - 0.00021 21.1 0.0 0.00033 20.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.17 CCL99613.1 - 0.0003 20.0 0.0 0.00061 19.0 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase MetW PF07021.12 CCL99613.1 - 0.0012 18.5 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_15 PF09445.10 CCL99613.1 - 0.0017 17.9 0.1 0.0026 17.4 0.1 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_24 PF13578.6 CCL99613.1 - 0.0031 18.5 0.0 0.011 16.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCL99613.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 CCL99613.1 - 0.018 14.3 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_29 PF03141.16 CCL99613.1 - 0.025 13.1 0.0 0.05 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase UPF0020 PF01170.18 CCL99613.1 - 0.033 13.9 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.6 CCL99613.1 - 0.097 12.7 0.0 0.24 11.4 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Mob_Pre PF01076.19 CCL99613.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Plasmid recombination enzyme PrmA PF06325.13 CCL99613.1 - 0.18 11.2 0.0 0.25 10.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 CCL99613.1 - 0.19 11.8 0.1 0.99 9.5 0.0 2.2 3 0 0 3 3 3 0 FtsJ-like methyltransferase PCI PF01399.27 CCL99614.1 - 8.3e-22 77.7 0.1 4.7e-21 75.3 0.0 2.3 2 0 0 2 2 2 1 PCI domain Rpn3_C PF08375.11 CCL99614.1 - 6.6e-21 74.5 0.2 6.6e-21 74.5 0.2 2.7 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal Sigma70_r1_2 PF00140.20 CCL99614.1 - 0.29 11.2 2.6 0.91 9.6 2.6 1.9 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 TPR_16 PF13432.6 CCL99614.1 - 2.2 9.0 13.7 2.3 9.0 1.4 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Profilin PF00235.19 CCL99615.1 - 9.7e-44 148.7 0.1 1.1e-43 148.6 0.1 1.0 1 0 0 1 1 1 1 Profilin Ribophorin_II PF05817.14 CCL99616.1 - 5.3e-27 94.7 0.0 5.7e-27 94.5 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Glyco_hydro_47 PF01532.20 CCL99617.1 - 1.4e-120 403.3 0.5 1.6e-120 403.1 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 F-box-like PF12937.7 CCL99618.1 - 0.0046 16.8 0.3 0.014 15.3 0.3 1.8 1 0 0 1 1 1 1 F-box-like APG9 PF04109.16 CCL99619.1 - 9e-210 697.7 6.9 1.1e-209 697.5 6.9 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 PLDc_2 PF13091.6 CCL99620.1 - 1.1e-09 38.3 0.0 0.00099 19.0 0.0 2.5 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CCL99620.1 - 3.5e-05 23.8 0.3 0.46 10.7 0.1 3.0 2 1 0 2 2 2 2 Phospholipase D Active site motif Pro_isomerase PF00160.21 CCL99621.1 - 3.9e-53 180.0 0.0 4.8e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 CCL99622.1 - 3.8e-28 97.1 22.2 8.9e-07 29.5 0.4 7.7 6 2 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 CCL99622.1 - 4.6e-10 38.8 0.4 0.18 10.4 0.0 4.1 2 1 2 4 4 4 4 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 CCL99622.1 - 0.00064 18.8 0.3 7.2 5.4 0.0 3.3 2 1 1 3 3 3 3 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 CCL99622.1 - 0.0034 17.0 1.1 0.4 10.2 0.1 2.6 2 0 0 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 CCL99622.1 - 0.0049 17.3 5.8 1.2 9.7 0.1 5.5 6 1 0 6 6 6 1 PQQ-like domain Nucleoporin_N PF08801.11 CCL99622.1 - 0.026 13.3 0.0 5.4 5.6 0.0 3.2 4 1 0 4 4 4 0 Nup133 N terminal like WD40 PF00400.32 CCL99623.1 - 1.7e-40 136.3 29.4 2.9e-06 27.9 0.1 8.2 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 CCL99623.1 - 4e-12 45.8 1.1 4e-12 45.8 1.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCL99623.1 - 8.9e-11 41.4 1.2 2.5e-10 40.0 1.2 1.9 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 CCL99623.1 - 1.7e-06 27.0 11.0 0.089 11.4 0.1 5.3 3 3 1 6 6 6 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CCL99623.1 - 2e-06 28.0 0.9 5.7 7.3 0.1 5.3 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCL99623.1 - 0.0013 18.4 2.4 0.81 9.2 0.1 3.4 3 1 1 4 4 4 2 PQQ-like domain PALB2_WD40 PF16756.5 CCL99623.1 - 0.29 10.0 7.8 2.7 6.8 0.0 3.5 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Fungal_trans PF04082.18 CCL99624.1 - 1.1e-11 44.2 0.1 2.8e-11 43.0 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCL99624.1 - 5.1e-05 23.3 7.5 5.1e-05 23.3 7.5 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FSA_C PF10479.9 CCL99625.1 - 3 5.9 8.6 3.6 5.6 8.6 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus GDA1_CD39 PF01150.17 CCL99627.1 - 2e-106 356.2 0.0 1.9e-105 352.9 0.0 1.9 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 CCL99627.1 - 0.0042 16.6 0.0 0.0066 15.9 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Radical_SAM_C PF16199.5 CCL99628.1 - 6e-30 103.1 0.0 1.1e-29 102.2 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CCL99628.1 - 3.9e-17 63.1 0.1 1.7e-16 61.0 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 CCL99628.1 - 5.7e-11 42.7 0.1 1.2e-10 41.6 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCL99628.1 - 1.9e-06 27.8 0.0 4.5e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCL99628.1 - 0.0047 17.3 0.1 0.013 16.0 0.1 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCL99628.1 - 0.046 13.7 0.0 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein MMM1 PF10296.9 CCL99629.1 - 6.5e-13 48.4 0.1 2.4e-08 33.4 0.1 2.9 2 1 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 Nuc_sug_transp PF04142.15 CCL99630.1 - 6.8e-97 324.4 7.2 9.1e-97 324.0 7.2 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 CCL99630.1 - 0.00067 19.0 0.3 0.00067 19.0 0.3 1.5 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport TPT PF03151.16 CCL99630.1 - 0.00093 18.6 0.8 0.00093 18.6 0.8 2.7 3 1 0 3 3 3 2 Triose-phosphate Transporter family UAA PF08449.11 CCL99630.1 - 0.026 13.7 11.3 0.063 12.5 11.3 1.5 1 1 0 1 1 1 0 UAA transporter family EamA PF00892.20 CCL99630.1 - 0.058 13.6 29.3 0.043 14.0 7.4 3.1 2 1 1 3 3 3 0 EamA-like transporter family DUF4231 PF14015.6 CCL99630.1 - 3.3 8.2 6.6 0.78 10.2 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Mit_ribos_Mrp51 PF11709.8 CCL99631.1 - 7.5e-13 48.8 4.6 3.4e-12 46.6 4.6 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit DUF4570 PF15134.6 CCL99631.1 - 0.022 14.8 0.1 0.06 13.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) UPF1_Zn_bind PF09416.10 CCL99633.1 - 2.3e-69 232.2 2.5 4.6e-69 231.2 2.5 1.5 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 CCL99633.1 - 7.9e-59 198.6 0.0 1.3e-58 197.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCL99633.1 - 4.3e-52 177.5 4.4 5.3e-31 108.4 0.5 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 CCL99633.1 - 3.6e-36 123.3 0.0 6.8e-36 122.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 CCL99633.1 - 1.4e-14 54.2 0.2 9.1e-14 51.6 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCL99633.1 - 1.1e-11 45.3 0.1 3.1e-11 43.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCL99633.1 - 9.1e-07 28.9 0.1 0.042 13.6 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 CCL99633.1 - 2.2e-05 23.9 0.5 0.00055 19.3 0.0 2.8 2 2 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 CCL99633.1 - 3.3e-05 24.0 0.0 6.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 CCL99633.1 - 0.00012 22.0 0.0 0.00026 20.9 0.0 1.6 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 CCL99633.1 - 0.00016 21.3 0.2 0.0023 17.5 0.1 2.3 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain Ribosomal_S13_N PF08069.12 CCL99633.1 - 0.0087 16.1 0.1 0.031 14.3 0.0 2.0 2 0 0 2 2 1 1 Ribosomal S13/S15 N-terminal domain PhoH PF02562.16 CCL99633.1 - 0.025 14.0 0.1 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein DEAD PF00270.29 CCL99633.1 - 0.03 14.1 0.2 0.057 13.2 0.2 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 CCL99633.1 - 0.048 13.9 0.1 0.12 12.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.14 CCL99633.1 - 0.053 12.7 0.1 0.68 9.0 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase Ribosomal_S27e PF01667.17 CCL99633.1 - 0.092 12.5 0.7 0.36 10.6 0.7 2.0 1 0 0 1 1 1 0 Ribosomal protein S27 AAA_10 PF12846.7 CCL99633.1 - 0.096 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain ATPase PF06745.13 CCL99633.1 - 0.096 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 KaiC SRP54 PF00448.22 CCL99633.1 - 0.13 11.9 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Erf4 PF10256.9 CCL99635.1 - 1.9e-30 105.3 0.0 2.6e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family bZIP_1 PF00170.21 CCL99636.1 - 1.9e-12 47.1 14.6 3.3e-12 46.3 14.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 CCL99636.1 - 6.8e-06 26.0 0.0 6.8e-06 26.0 0.0 4.1 3 1 1 4 4 1 1 Transcription factor PAP1 DivIC PF04977.15 CCL99636.1 - 0.001 18.8 1.4 0.0023 17.7 1.4 1.6 1 0 0 1 1 1 1 Septum formation initiator bZIP_2 PF07716.15 CCL99636.1 - 0.0031 17.6 13.6 0.0031 17.6 13.6 2.2 1 1 1 2 2 2 1 Basic region leucine zipper SHE3 PF17078.5 CCL99636.1 - 0.0062 16.3 4.3 0.011 15.4 4.3 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 GvpL_GvpF PF06386.11 CCL99636.1 - 0.052 13.5 3.1 0.09 12.7 3.1 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF APC_u15 PF16636.5 CCL99636.1 - 0.14 12.6 0.3 0.14 12.6 0.3 2.8 2 1 1 3 3 2 0 Unstructured region on APC between APC_crr regions 5 and 6 Coat_F PF07875.12 CCL99636.1 - 0.15 12.3 0.3 0.28 11.4 0.3 1.4 1 0 0 1 1 1 0 Coat F domain TSC22 PF01166.18 CCL99636.1 - 0.21 11.9 4.0 2.3 8.6 4.1 2.4 1 1 0 1 1 1 0 TSC-22/dip/bun family YabA PF06156.13 CCL99636.1 - 0.23 12.1 1.9 0.44 11.2 1.9 1.4 1 0 0 1 1 1 0 Initiation control protein YabA rRNA_processing PF08524.11 CCL99636.1 - 0.39 10.7 9.8 0.74 9.8 9.8 1.3 1 0 0 1 1 1 0 rRNA processing Glutaredoxin2_C PF04399.13 CCL99636.1 - 0.4 10.5 2.0 0.77 9.6 2.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain DUF5094 PF17015.5 CCL99636.1 - 3.2 7.8 6.5 6 6.9 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Pox_G5 PF04599.12 CCL99636.1 - 4.5 6.2 4.6 6.6 5.6 4.6 1.1 1 0 0 1 1 1 0 Poxvirus G5 protein ArsA_ATPase PF02374.15 CCL99637.1 - 1.5e-108 362.6 0.9 1.7e-108 362.4 0.9 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 CCL99637.1 - 1.3e-13 51.3 0.1 3.5e-13 49.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 CCL99637.1 - 7.7e-11 42.1 0.0 1.8e-10 41.0 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CCL99637.1 - 2.2e-05 24.1 2.9 7.3e-05 22.3 0.8 2.7 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 CCL99637.1 - 2.2e-05 24.0 0.0 5.3e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 CCL99637.1 - 2.5e-05 23.9 0.0 0.00014 21.4 0.0 1.9 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 CCL99637.1 - 2.6e-05 23.9 0.3 0.00046 19.9 0.1 2.2 1 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 CCL99637.1 - 0.00033 20.3 0.5 0.0022 17.6 0.5 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CCL99637.1 - 0.011 15.5 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CCL99637.1 - 0.062 12.6 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 CCL99637.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CCL99637.1 - 0.15 12.6 0.1 0.37 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain SRP68 PF16969.5 CCL99638.1 - 3.8e-66 224.3 5.1 1.4e-64 219.1 1.3 2.0 2 0 0 2 2 2 2 RNA-binding signal recognition particle 68 SNF2_N PF00176.23 CCL99639.1 - 5.3e-72 242.4 0.2 1.2e-71 241.3 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Bromodomain PF00439.25 CCL99639.1 - 8.6e-24 83.4 0.1 3.2e-23 81.6 0.1 2.0 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.31 CCL99639.1 - 8.8e-20 71.1 0.8 7.8e-18 64.8 0.0 3.5 4 0 0 4 4 4 1 Helicase conserved C-terminal domain HSA PF07529.13 CCL99639.1 - 6e-19 68.1 6.4 2.3e-18 66.3 6.4 2.1 1 0 0 1 1 1 1 HSA SnAC PF14619.6 CCL99639.1 - 8.6e-12 45.5 0.5 8.6e-12 45.5 0.5 3.5 3 0 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 CCL99639.1 - 1.7e-11 43.7 0.9 5e-11 42.1 0.9 1.9 1 0 0 1 1 1 1 QLQ ResIII PF04851.15 CCL99639.1 - 1.8e-10 41.1 0.0 6.3e-10 39.3 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UNC119_bdg PF15435.6 CCL99639.1 - 0.0056 16.3 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 UNC119-binding protein C5orf30 homologue Ribosomal_60s PF00428.19 CCL99639.1 - 0.14 12.8 0.1 0.14 12.8 0.1 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein DBINO PF13892.6 CCL99639.1 - 7.4 6.9 14.3 0.96 9.8 9.3 2.1 2 0 0 2 2 2 0 DNA-binding domain Ku PF02735.16 CCL99640.1 - 6.2e-28 97.9 0.0 1.6e-27 96.6 0.0 1.7 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 CCL99640.1 - 3.4e-26 91.8 0.0 8.5e-26 90.5 0.0 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.15 CCL99640.1 - 4.6e-05 23.3 0.0 0.00011 22.1 0.0 1.7 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA PF00092.28 CCL99640.1 - 0.001 19.4 0.0 0.043 14.1 0.0 2.8 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CCL99640.1 - 0.024 15.3 0.0 0.25 12.0 0.0 2.5 1 1 0 1 1 1 0 von Willebrand factor type A domain Pkinase_Tyr PF07714.17 CCL99641.1 - 3.4e-33 115.0 0.0 4.9e-33 114.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCL99641.1 - 5.1e-30 104.7 0.0 9.9e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCL99641.1 - 0.0023 17.9 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCL99641.1 - 0.062 12.6 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 CCL99641.1 - 0.085 11.9 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 CCL99641.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CCL99642.1 - 5.3e-08 32.5 0.0 2.8e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99642.1 - 0.0023 17.3 0.0 0.085 12.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Exo_endo_phos PF03372.23 CCL99643.1 - 5.9e-19 68.5 0.3 1.6e-17 63.8 0.3 2.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 CCL99643.1 - 1.2e-16 60.2 27.0 3.6e-09 36.3 5.7 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 CCL99643.1 - 2.4e-12 46.8 9.9 6.8e-06 26.3 2.3 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) Pterin_4a PF01329.19 CCL99643.1 - 0.0068 16.6 0.0 0.025 14.8 0.0 2.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase LRR_1 PF00560.33 CCL99643.1 - 0.026 15.0 6.8 16 6.5 0.9 4.9 3 1 1 4 4 4 0 Leucine Rich Repeat Herpes_capsid PF06112.11 CCL99643.1 - 3.3 7.8 12.5 9.6 6.2 12.5 1.8 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein MDD_C PF18376.1 CCL99644.1 - 1.2e-70 237.0 0.0 1.6e-70 236.6 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 CCL99644.1 - 4e-06 27.0 5.3 9.3e-06 25.8 5.3 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain Cupin_2 PF07883.11 CCL99645.1 - 2.4e-14 52.8 0.5 3.9e-14 52.1 0.5 1.4 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 CCL99645.1 - 1.8e-05 24.7 0.0 2.4e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_3 PF05899.12 CCL99645.1 - 9.4e-05 22.0 0.0 0.00013 21.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 CCL99645.1 - 0.00025 20.7 0.0 0.00033 20.3 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.7 CCL99645.1 - 0.031 14.0 0.0 0.04 13.6 0.0 1.1 1 0 0 1 1 1 0 Cupin AraC_binding PF02311.19 CCL99645.1 - 0.049 13.5 0.1 0.086 12.7 0.1 1.4 1 0 0 1 1 1 0 AraC-like ligand binding domain GPI PF06560.11 CCL99645.1 - 0.053 12.8 0.1 0.42 9.9 0.0 1.9 2 0 0 2 2 2 0 Glucose-6-phosphate isomerase (GPI) JmjC PF02373.22 CCL99645.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 JmjC domain, hydroxylase Rhv PF00073.20 CCL99645.1 - 0.13 11.9 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 picornavirus capsid protein Asp PF00026.23 CCL99647.1 - 2.4e-63 214.5 1.1 3.1e-63 214.1 1.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCL99647.1 - 8.3e-12 45.7 3.7 9.8e-11 42.2 2.5 2.7 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCL99647.1 - 0.0025 18.4 1.4 0.6 10.8 0.1 3.5 2 2 0 2 2 2 1 Aspartyl protease LDB19 PF13002.7 CCL99647.1 - 0.014 15.1 0.5 0.032 13.9 0.0 1.8 2 0 0 2 2 2 0 Arrestin_N terminal like DUF2568 PF10823.8 CCL99648.1 - 0.056 13.7 0.3 0.056 13.7 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2568) Asp PF00026.23 CCL99649.1 - 3.6e-66 223.7 2.4 4.5e-66 223.4 2.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCL99649.1 - 2.2e-14 54.1 4.0 1.2e-11 45.2 2.4 3.1 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CCL99649.1 - 0.098 12.4 0.2 3 7.6 0.2 2.4 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal TPR_2 PF07719.17 CCL99651.1 - 1e-23 81.5 35.6 0.00016 21.5 0.2 13.3 15 0 0 15 15 15 6 Tetratricopeptide repeat TPR_19 PF14559.6 CCL99651.1 - 1.3e-23 83.3 34.3 1.3e-05 25.6 0.1 10.9 10 4 1 12 12 11 8 Tetratricopeptide repeat TPR_1 PF00515.28 CCL99651.1 - 8.5e-22 76.0 28.7 8.4e-05 22.2 0.2 11.1 14 0 0 14 14 14 6 Tetratricopeptide repeat TPR_8 PF13181.6 CCL99651.1 - 3.6e-17 61.1 19.8 0.00044 20.2 0.1 10.5 12 0 0 12 12 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 CCL99651.1 - 6.3e-14 51.5 35.7 0.02 15.7 0.5 13.2 10 3 5 15 15 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 CCL99651.1 - 2.1e-13 50.3 30.4 4.2e-05 23.7 2.5 9.4 7 4 3 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 CCL99651.1 - 7.3e-13 48.9 30.5 0.00011 22.8 0.5 10.2 10 1 1 11 11 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCL99651.1 - 4e-12 45.9 28.7 6.8e-05 23.3 0.4 10.3 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCL99651.1 - 1.4e-09 37.6 18.0 0.98 9.9 0.0 10.0 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCL99651.1 - 1.3e-08 34.2 16.7 0.29 11.3 0.2 8.1 8 0 0 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCL99651.1 - 2e-05 24.8 16.4 0.56 10.5 0.1 6.3 5 1 2 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CCL99651.1 - 5.2e-05 22.8 5.7 1.2 8.9 0.0 6.9 7 1 1 8 8 8 1 TPR repeat TPR_10 PF13374.6 CCL99651.1 - 0.0016 18.3 32.9 0.14 12.0 1.0 8.9 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_4 PF07721.14 CCL99651.1 - 0.35 11.6 0.0 0.35 11.6 0.0 5.8 7 0 0 7 7 5 0 Tetratricopeptide repeat ChAPs PF09295.10 CCL99651.1 - 1.8 7.5 6.1 19 4.1 0.0 3.8 4 1 1 5 5 5 0 ChAPs (Chs5p-Arf1p-binding proteins) Myb_DNA-binding PF00249.31 CCL99652.1 - 2.4e-11 43.6 0.2 6.5e-11 42.2 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 CCL99652.1 - 6.1e-11 42.5 0.0 1.9e-10 40.9 0.0 1.8 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 CCL99652.1 - 0.00054 20.1 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain APC1_C PF18122.1 CCL99652.1 - 0.025 14.5 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain DUF3795 PF12675.7 CCL99652.1 - 0.43 11.0 6.1 0.94 9.9 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) PALP PF00291.25 CCL99653.1 - 2.1e-48 165.2 0.1 2.9e-46 158.2 0.1 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 CCL99653.1 - 0.082 12.9 0.3 2.5 8.1 0.1 2.8 2 1 1 3 3 3 0 Zinc-binding dehydrogenase CoA_binding_2 PF13380.6 CCL99654.1 - 3.9e-32 111.2 0.0 4.4e-32 111.0 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 CCL99654.1 - 0.05 14.3 0.0 0.072 13.8 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain Mito_carr PF00153.27 CCL99655.1 - 3.8e-63 209.4 3.6 1.1e-20 73.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein NUDIX PF00293.28 CCL99656.1 - 9.3e-19 67.8 0.0 1.7e-18 66.9 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 CCL99656.1 - 2.5e-09 37.7 0.0 9.3e-09 35.9 0.0 2.0 2 1 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 CCL99656.1 - 0.00083 19.0 0.3 0.0018 17.9 0.3 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.6 CCL99656.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.5 1 0 0 1 1 1 0 Nudix N-terminal zinc_ribbon_2 PF13240.6 CCL99656.1 - 1 9.2 3.2 0.33 10.7 0.3 1.7 2 0 0 2 2 2 0 zinc-ribbon domain NUDIX PF00293.28 CCL99657.1 - 3.3e-18 66.0 0.0 5.2e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 CCL99657.1 - 8.1e-07 29.6 0.2 2.3e-06 28.2 0.2 1.8 1 1 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 CCL99657.1 - 0.00057 19.5 2.3 0.0011 18.6 2.3 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 CCL99657.1 - 0.18 11.6 0.7 0.33 10.7 0.7 1.4 1 0 0 1 1 1 0 zinc-ribbon domain DUF3844 PF12955.7 CCL99659.1 - 2.1e-31 108.2 5.1 3.3e-31 107.6 5.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) EGF_2 PF07974.13 CCL99659.1 - 5.1 7.5 10.7 12 6.4 10.7 1.7 1 1 0 1 1 1 0 EGF-like domain Rubis-subs-bind PF09273.11 CCL99660.1 - 2e-14 54.4 0.1 3.9e-14 53.5 0.1 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 CCL99660.1 - 3.7e-14 53.5 0.0 1.2e-13 51.8 0.0 1.9 1 1 0 1 1 1 1 SET domain CRAL_TRIO PF00650.20 CCL99661.1 - 3.6e-07 30.0 0.0 0.038 13.7 0.0 2.6 3 0 0 3 3 3 2 CRAL/TRIO domain Metallophos PF00149.28 CCL99662.1 - 8e-27 95.1 0.0 1e-26 94.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CTP_transf_like PF01467.26 CCL99664.1 - 1.7e-11 44.5 0.0 2.3e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like 2Fe-2S_Ferredox PF11591.8 CCL99664.1 - 4.7 7.2 6.8 0.46 10.4 1.6 2.0 2 0 0 2 2 2 0 Ferredoxin chloroplastic transit peptide FOXP-CC PF16159.5 CCL99665.1 - 4.1e-05 24.1 3.4 0.091 13.4 0.2 2.7 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2 PF00096.26 CCL99665.1 - 0.00083 19.7 8.4 0.0056 17.1 0.0 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_12 PF18658.1 CCL99665.1 - 0.036 13.6 3.8 0.9 9.2 0.0 2.9 1 1 2 3 3 3 0 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 CCL99665.1 - 0.18 12.8 12.0 2 9.5 0.0 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CCL99665.1 - 1.2 9.1 4.8 18 5.4 0.7 3.2 2 1 0 2 2 2 0 zinc-finger of a C2HC-type OHCU_decarbox PF09349.10 CCL99666.1 - 1.9e-32 112.9 0.0 2.3e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 OHCU decarboxylase DnaJ PF00226.31 CCL99667.1 - 2.4e-19 69.2 0.1 4.5e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Casc1 PF12366.8 CCL99667.1 - 0.053 13.0 1.8 0.076 12.5 1.8 1.4 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Bac_small_YrzI PF09501.10 CCL99667.1 - 0.47 10.6 9.9 0.75 10.0 1.0 2.6 1 1 1 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) MAJIN PF15077.6 CCL99667.1 - 3.7 7.3 8.8 6 6.6 7.6 1.8 1 1 1 2 2 2 0 Membrane-anchored junction protein SH3_1 PF00018.28 CCL99670.1 - 1.1e-18 66.5 2.1 2e-08 33.7 0.1 3.1 2 1 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CCL99670.1 - 3.2e-14 52.5 0.8 2e-06 27.6 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SAM_2 PF07647.17 CCL99670.1 - 3.6e-11 43.0 0.0 6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CCL99670.1 - 4.4e-10 39.8 0.0 7.5e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 CCL99670.1 - 1.1e-07 31.4 0.1 5.7e-05 22.7 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain RA PF00788.23 CCL99670.1 - 6.1e-07 30.0 0.0 1.2e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SH3_3 PF08239.11 CCL99670.1 - 0.00041 20.6 2.0 0.96 9.8 0.1 2.6 2 0 0 2 2 2 2 Bacterial SH3 domain DnaJ PF00226.31 CCL99671.1 - 3.6e-20 71.8 0.2 6.4e-20 71.0 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Peptidase_C12 PF01088.21 CCL99672.1 - 1.1e-48 165.8 0.0 2.2e-48 164.8 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Cyto_heme_lyase PF01265.17 CCL99674.1 - 3.9e-83 279.4 10.3 2.5e-81 273.5 10.3 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase Tim44 PF04280.15 CCL99675.1 - 1.1e-35 122.9 1.0 2.3e-35 121.9 0.6 1.8 2 0 0 2 2 2 1 Tim44-like domain DUF3813 PF12758.7 CCL99675.1 - 0.042 14.2 5.3 1.2 9.5 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) CENP-O PF09496.10 CCL99675.1 - 0.048 13.6 3.2 0.06 13.3 1.0 2.0 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component Collagen_mid PF15984.5 CCL99675.1 - 0.073 12.8 0.1 2 8.1 0.1 2.2 2 0 0 2 2 2 0 Bacterial collagen, middle region DUF1778 PF08681.11 CCL99675.1 - 1.4 8.9 4.8 48 4.0 1.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1778) DUF2203 PF09969.9 CCL99675.1 - 1.7 9.4 5.0 1.4 9.6 2.3 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) WD40 PF00400.32 CCL99676.1 - 2.4e-07 31.3 7.7 0.52 11.3 0.1 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL99676.1 - 3.5e-07 30.4 0.1 0.044 14.1 0.0 3.4 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TMF_TATA_bd PF12325.8 CCL99676.1 - 0.012 15.8 0.5 0.024 14.8 0.5 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Utp8 PF10395.9 CCL99676.1 - 0.033 12.7 0.1 0.33 9.4 0.0 2.0 2 0 0 2 2 2 0 Utp8 family WD40_alt PF14077.6 CCL99676.1 - 0.076 12.9 0.9 0.16 11.8 0.9 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif Nucleoporin_N PF08801.11 CCL99676.1 - 0.12 11.0 0.1 1.2 7.9 0.1 2.0 1 1 1 2 2 2 0 Nup133 N terminal like Coatomer_WDAD PF04053.14 CCL99676.1 - 0.18 10.8 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region NADH-u_ox-rdase PF10785.9 CCL99677.1 - 3.3e-30 104.6 0.1 4.7e-30 104.1 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 CCL99677.1 - 5.1e-11 42.4 0.0 6.7e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit zf-RanBP PF00641.18 CCL99678.1 - 5.3e-10 38.4 14.6 5.3e-06 25.6 4.0 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Prim_Zn_Ribbon PF08273.12 CCL99678.1 - 0.032 14.5 0.1 4.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase zf-Sec23_Sec24 PF04810.15 CCL99678.1 - 0.16 12.1 1.1 20 5.3 0.1 2.7 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 CCL99678.1 - 0.81 9.1 9.8 1.9 7.9 1.3 2.7 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-P11 PF03854.14 CCL99678.1 - 1.1 9.0 4.8 0.79 9.4 0.4 2.3 2 0 0 2 2 2 0 P-11 zinc finger Pkinase PF00069.25 CCL99679.1 - 3.6e-74 249.5 0.0 4.2e-74 249.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99679.1 - 1.6e-31 109.5 0.0 4.7e-31 108.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCL99679.1 - 0.0067 15.8 0.0 0.18 11.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCL99679.1 - 0.015 15.2 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCL99679.1 - 0.021 13.8 0.0 0.23 10.4 0.0 2.0 1 1 0 1 1 1 0 Haspin like kinase domain aGPT-Pplase1 PF18723.1 CCL99680.1 - 7e-93 311.1 0.0 3.1e-65 220.4 0.1 2.1 2 0 0 2 2 2 2 alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 1 Chromo PF00385.24 CCL99680.1 - 6.3e-10 38.8 0.1 1.2e-09 37.9 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain adh_short_C2 PF13561.6 CCL99681.1 - 5.1e-43 147.3 0.4 4e-41 141.1 0.4 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCL99681.1 - 9e-38 129.7 0.5 2e-37 128.5 0.5 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCL99681.1 - 1.2e-06 28.6 0.2 2.4e-06 27.6 0.0 1.6 2 0 0 2 2 2 1 KR domain 3HCDH_N PF02737.18 CCL99681.1 - 0.04 13.8 0.3 0.12 12.2 0.1 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 CCL99682.1 - 4e-43 147.6 0.0 3.1e-41 141.5 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCL99682.1 - 2.5e-34 118.5 0.1 5.4e-34 117.4 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCL99682.1 - 1.6e-05 24.9 0.0 3.5e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 KR domain MotA_activ PF09114.10 CCL99682.1 - 0.1 12.7 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 Transcription factor MotA, activation domain Pro-kuma_activ PF09286.11 CCL99683.1 - 1.6e-36 125.7 0.0 2.3e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCL99683.1 - 2.1e-08 33.8 1.6 4.4e-08 32.7 1.6 1.6 1 0 0 1 1 1 1 Subtilase family FF PF01846.19 CCL99684.1 - 3.2e-34 116.9 5.6 7e-11 42.1 0.0 5.8 5 0 0 5 5 5 4 FF domain WW PF00397.26 CCL99684.1 - 7.4e-11 41.9 17.0 5.7e-06 26.3 6.1 2.8 2 0 0 2 2 2 2 WW domain TarH PF02203.15 CCL99684.1 - 4.8 7.1 6.7 3.9 7.4 0.3 3.0 3 0 0 3 3 3 0 Tar ligand binding domain homologue Ribosomal_L21p PF00829.21 CCL99685.1 - 5.6e-26 90.8 0.5 6.8e-26 90.5 0.5 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein UvrA_inter PF17760.1 CCL99685.1 - 0.016 15.3 0.1 0.026 14.6 0.1 1.3 1 0 0 1 1 1 0 UvrA interaction domain ATP-synt_ab PF00006.25 CCL99686.1 - 7.1e-73 244.8 0.0 1e-72 244.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CCL99686.1 - 9e-43 145.6 0.0 1.5e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CCL99686.1 - 1.3e-17 64.0 0.9 3.1e-17 62.9 0.9 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain MFS_1 PF07690.16 CCL99688.1 - 6.2e-47 160.2 43.0 6.2e-47 160.2 43.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCL99688.1 - 2.2e-09 36.7 1.3 2.2e-09 36.7 1.3 3.6 2 2 1 3 3 3 2 Sugar (and other) transporter DUF2408 PF10303.9 CCL99689.1 - 1e-61 207.4 0.1 1.1e-42 145.8 0.0 4.3 4 0 0 4 4 4 4 Protein of unknown function (DUF2408) Baculo_PEP_C PF04513.12 CCL99689.1 - 0.96 9.5 4.0 2.9 7.9 0.7 2.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin_1 PF12718.7 CCL99690.1 - 1.4e-44 151.7 32.7 1.4e-29 103.1 18.6 2.1 2 0 0 2 2 2 2 Tropomyosin like Tropomyosin PF00261.20 CCL99690.1 - 2.2e-12 46.9 30.6 1.7e-05 24.3 4.5 3.2 2 1 1 3 3 3 3 Tropomyosin Uso1_p115_C PF04871.13 CCL99690.1 - 4.2e-05 23.9 7.5 4.2e-05 23.9 7.5 2.4 1 1 1 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region GAS PF13851.6 CCL99690.1 - 0.00028 20.3 23.4 0.0061 15.9 11.7 2.3 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding BRE1 PF08647.11 CCL99690.1 - 0.0024 17.9 25.4 0.15 12.1 6.4 3.6 2 1 2 4 4 4 2 BRE1 E3 ubiquitin ligase CENP-F_leu_zip PF10473.9 CCL99690.1 - 0.0029 17.6 27.8 0.0052 16.8 4.6 2.6 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KELK PF15796.5 CCL99690.1 - 0.0034 17.8 6.0 0.0034 17.8 6.0 3.7 2 1 2 4 4 2 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase TMF_TATA_bd PF12325.8 CCL99690.1 - 0.0086 16.3 22.7 0.15 12.2 2.2 3.1 2 1 1 3 3 3 3 TATA element modulatory factor 1 TATA binding DHR10 PF18595.1 CCL99690.1 - 0.014 15.5 33.1 0.04 14.0 12.5 3.2 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain HrpB7 PF09486.10 CCL99690.1 - 0.014 15.7 6.2 0.014 15.7 6.2 2.9 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF3450 PF11932.8 CCL99690.1 - 0.015 14.6 23.9 0.12 11.6 1.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) CCDC-167 PF15188.6 CCL99690.1 - 0.032 14.5 4.0 0.032 14.5 4.0 3.1 2 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 HHV-5_US34A PF17087.5 CCL99690.1 - 0.039 14.1 7.5 0.21 11.7 3.3 2.4 2 0 0 2 2 2 0 Herpesvirus US34A protein family RSS_P20 PF11757.8 CCL99690.1 - 0.061 13.8 0.6 0.061 13.8 0.6 3.0 1 1 3 4 4 3 0 Suppressor of RNA silencing P21-like N-terminal domain Laminin_II PF06009.12 CCL99690.1 - 0.069 13.2 17.8 0.63 10.1 0.6 3.2 2 1 2 4 4 4 0 Laminin Domain II DUF4200 PF13863.6 CCL99690.1 - 0.1 13.0 27.4 0.22 12.0 3.7 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) TPR_MLP1_2 PF07926.12 CCL99690.1 - 0.26 11.3 30.7 0.26 11.4 3.9 3.4 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein ERM PF00769.19 CCL99690.1 - 0.26 11.1 31.0 0.47 10.2 6.8 2.7 1 1 0 2 2 2 0 Ezrin/radixin/moesin family LMBR1 PF04791.16 CCL99690.1 - 0.28 10.1 8.8 0.34 9.8 8.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Fez1 PF06818.15 CCL99690.1 - 0.33 11.4 21.6 0.73 10.3 21.3 1.7 1 1 0 1 1 1 0 Fez1 DUF725 PF05267.12 CCL99690.1 - 0.47 10.5 5.8 0.74 9.8 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF725) Spc7 PF08317.11 CCL99690.1 - 0.54 9.1 26.0 1.6 7.5 11.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein T3SSipB PF16535.5 CCL99690.1 - 0.76 10.2 22.4 0.99 9.9 14.7 2.2 1 1 1 2 2 2 0 Type III cell invasion protein SipB Jnk-SapK_ap_N PF09744.9 CCL99690.1 - 0.77 10.0 27.3 1.6 9.0 16.4 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 CCL99690.1 - 0.85 9.1 16.6 66 2.9 16.6 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit LIN37 PF15306.6 CCL99690.1 - 1 9.6 9.1 3.3 7.9 9.0 1.9 1 1 0 1 1 1 0 LIN37 Cep57_CLD_2 PF14197.6 CCL99690.1 - 1 9.5 24.3 0.96 9.6 4.1 3.8 2 1 0 3 3 3 0 Centrosome localisation domain of PPC89 DUF3584 PF12128.8 CCL99690.1 - 1 6.8 28.1 0.99 6.8 15.9 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3584) FliD_C PF07195.12 CCL99690.1 - 1.1 8.7 13.7 12 5.2 11.9 2.6 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus DUF4407 PF14362.6 CCL99690.1 - 1.4 8.2 23.3 11 5.2 23.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PspA_IM30 PF04012.12 CCL99690.1 - 1.8 8.1 27.2 0.13 11.8 13.3 2.3 1 1 1 2 2 2 0 PspA/IM30 family HMMR_N PF15905.5 CCL99690.1 - 1.9 7.9 26.1 42 3.5 26.4 2.1 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Lebercilin PF15619.6 CCL99690.1 - 1.9 8.1 29.6 2.6 7.7 16.7 2.4 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease HetR_C PF18460.1 CCL99690.1 - 2.2 8.2 12.4 0.56 10.2 1.2 3.3 2 1 1 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain TMF_DNA_bd PF12329.8 CCL99690.1 - 2.3 8.3 27.6 5.1 7.2 1.7 3.5 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 CCL99690.1 - 2.3 8.4 14.6 17 5.6 2.8 2.9 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CLZ PF16526.5 CCL99690.1 - 2.4 8.6 26.0 1.6 9.1 3.4 3.9 1 1 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF724 PF05266.14 CCL99690.1 - 2.8 7.7 22.8 3 7.6 11.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Occludin_ELL PF07303.13 CCL99690.1 - 3.5 8.4 16.1 6.6 7.5 3.2 3.3 1 1 3 4 4 4 0 Occludin homology domain Seryl_tRNA_N PF02403.22 CCL99690.1 - 3.8 7.8 25.2 6.6 7.0 16.0 2.6 3 1 0 3 3 2 0 Seryl-tRNA synthetase N-terminal domain SlyX PF04102.12 CCL99690.1 - 3.8 8.2 24.3 0.41 11.3 3.1 4.1 2 1 2 4 4 4 0 SlyX Wtap PF17098.5 CCL99690.1 - 4.5 7.2 18.4 1e+02 2.8 18.6 2.7 1 1 0 1 1 1 0 WTAP/Mum2p family NAD_binding_4 PF07993.12 CCL99690.1 - 4.6 6.3 8.1 1.3e+02 1.6 8.1 2.2 1 1 0 1 1 1 0 Male sterility protein Csm1_N PF18504.1 CCL99690.1 - 4.7 7.6 26.4 5.2 7.5 7.0 3.8 2 1 2 4 4 4 0 Csm1 N-terminal domain LPP PF04728.13 CCL99690.1 - 5.2 7.5 15.9 23 5.5 0.8 4.2 4 0 0 4 4 4 0 Lipoprotein leucine-zipper DUF722 PF05263.11 CCL99690.1 - 5.9 7.1 10.5 1 9.6 1.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF722) OmpH PF03938.14 CCL99690.1 - 7.6 6.9 31.1 20 5.5 6.4 2.9 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) CREPT PF16566.5 CCL99690.1 - 7.9 6.7 17.2 3.1 8.0 0.5 3.2 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1664 PF07889.12 CCL99690.1 - 8.5 6.4 13.9 8 6.5 1.7 3.2 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) SelR PF01641.18 CCL99691.1 - 1.6e-43 147.6 0.0 1.9e-43 147.4 0.0 1.0 1 0 0 1 1 1 1 SelR domain ADD_ATRX PF17981.1 CCL99691.1 - 9.3e-05 22.2 0.1 0.045 13.6 0.0 2.2 2 0 0 2 2 2 2 Cysteine Rich ADD domain zf-Mss51 PF13824.6 CCL99691.1 - 0.0033 17.5 0.3 0.047 13.8 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 Yippee-Mis18 PF03226.14 CCL99691.1 - 0.019 15.2 0.2 0.086 13.1 0.2 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 CCL99691.1 - 0.022 14.8 0.2 0.074 13.1 0.1 1.8 1 1 1 2 2 2 0 Double zinc ribbon GFA PF04828.14 CCL99691.1 - 0.031 14.6 0.2 0.33 11.3 0.0 2.0 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme TF_Zn_Ribbon PF08271.12 CCL99691.1 - 0.084 12.4 4.3 6 6.5 0.1 3.2 3 0 0 3 3 3 0 TFIIB zinc-binding zf-ACC PF17848.1 CCL99691.1 - 0.18 11.9 1.2 1.9 8.7 0.1 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Glyco_hydro_3_C PF01915.22 CCL99692.1 - 6.4e-39 134.0 0.0 9.8e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCL99692.1 - 6e-29 101.4 0.0 9.2e-29 100.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCL99692.1 - 2e-08 34.2 0.0 5.7e-08 32.8 0.0 1.8 2 0 0 2 2 2 1 Fibronectin type III-like domain ABC_membrane PF00664.23 CCL99693.1 - 1e-56 192.6 38.5 1.1e-32 113.8 13.5 2.9 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCL99693.1 - 6.3e-39 133.6 0.0 1.1e-18 68.1 0.0 3.3 2 1 0 2 2 2 2 ABC transporter MMR_HSR1 PF01926.23 CCL99693.1 - 2.6e-05 24.3 1.4 0.099 12.7 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase SMC_N PF02463.19 CCL99693.1 - 0.00016 21.2 0.1 1.1 8.7 0.0 3.8 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCL99693.1 - 0.0002 21.0 1.2 0.041 13.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CCL99693.1 - 0.00049 20.7 0.3 0.56 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCL99693.1 - 0.00063 19.7 0.1 0.35 10.8 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 CCL99693.1 - 0.001 19.2 3.4 0.15 12.1 0.1 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_16 PF13191.6 CCL99693.1 - 0.0018 18.7 0.0 1 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CCL99693.1 - 0.0033 17.2 0.0 1.9 8.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCL99693.1 - 0.0037 17.5 0.0 0.32 11.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CCL99693.1 - 0.0038 17.1 0.3 2.9 7.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CCL99693.1 - 0.0058 15.7 0.0 0.088 11.8 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein MeaB PF03308.16 CCL99693.1 - 0.015 14.3 0.1 3.4 6.6 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4574 PF15141.6 CCL99693.1 - 0.019 14.9 0.0 0.058 13.3 0.0 1.8 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Zeta_toxin PF06414.12 CCL99693.1 - 0.031 13.6 0.0 7.2 5.8 0.0 3.2 3 0 0 3 3 3 0 Zeta toxin FtsK_SpoIIIE PF01580.18 CCL99693.1 - 0.034 13.5 1.0 0.64 9.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 CCL99693.1 - 0.036 13.7 3.0 1.7 8.2 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 CCL99693.1 - 0.038 14.0 0.9 2 8.5 0.4 2.5 2 0 0 2 2 2 0 Dynamin family MobB PF03205.14 CCL99693.1 - 0.039 13.8 2.3 1.2 9.0 0.2 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 CCL99693.1 - 0.07 12.7 0.2 13 5.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 CCL99693.1 - 0.08 12.7 0.7 39 3.9 0.0 3.6 3 1 1 4 4 4 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CCL99693.1 - 0.12 12.3 1.6 11 5.9 0.1 2.9 3 0 0 3 3 3 0 NTPase AAA_24 PF13479.6 CCL99693.1 - 0.16 11.7 0.1 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCL99693.1 - 0.19 12.2 0.4 27 5.2 0.1 3.1 3 1 0 3 3 2 0 RNA helicase TrwB_AAD_bind PF10412.9 CCL99693.1 - 0.2 10.5 1.1 4.6 6.0 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Roc PF08477.13 CCL99693.1 - 0.24 11.6 0.3 18 5.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 CCL99693.1 - 0.26 11.0 1.1 41 3.9 0.0 3.3 2 1 1 3 3 3 0 DEAD/DEAH box helicase NB-ARC PF00931.22 CCL99693.1 - 0.45 9.6 1.8 11 5.1 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain Pox_A32 PF04665.12 CCL99693.1 - 0.69 9.3 2.1 1.9 7.9 0.1 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein 60KD_IMP PF02096.20 CCL99693.1 - 1.5 8.7 7.1 0.18 11.7 1.7 2.3 2 0 0 2 2 1 0 60Kd inner membrane protein NACHT PF05729.12 CCL99693.1 - 4.5 7.2 6.1 36 4.2 0.1 3.3 4 0 0 4 4 3 0 NACHT domain Epimerase PF01370.21 CCL99694.1 - 2.9e-22 79.3 0.0 4.5e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCL99694.1 - 3e-16 59.3 0.0 4.5e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCL99694.1 - 1.3e-12 47.8 0.1 1.8e-11 44.0 0.0 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCL99694.1 - 3.9e-10 39.9 0.1 7.5e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCL99694.1 - 7.6e-10 38.4 0.2 9.9e-09 34.7 0.2 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 CCL99694.1 - 1.6e-06 27.9 0.2 3.8e-06 26.6 0.1 1.7 1 1 1 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 CCL99694.1 - 2e-06 27.1 0.1 3.7e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CCL99694.1 - 1.2e-05 24.9 0.1 2.3e-05 23.9 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.20 CCL99694.1 - 0.0014 18.8 0.2 0.0027 17.8 0.2 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 CCL99694.1 - 0.0057 16.6 0.1 0.099 12.5 0.1 2.3 1 1 0 1 1 1 1 KR domain DUF2150 PF09920.9 CCL99694.1 - 0.053 13.5 0.1 9 6.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) RmlD_sub_bind PF04321.17 CCL99694.1 - 0.088 11.9 0.0 0.22 10.6 0.0 1.7 1 0 0 1 1 1 0 RmlD substrate binding domain adh_short_C2 PF13561.6 CCL99694.1 - 0.1 12.2 0.1 0.22 11.0 0.1 1.7 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Peptidase_S9 PF00326.21 CCL99695.1 - 4.5e-34 117.8 0.0 6.7e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 CCL99695.1 - 2.6e-08 33.6 1.5 0.00018 21.4 1.2 2.9 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Hydrolase_4 PF12146.8 CCL99695.1 - 3.3e-06 26.5 0.1 0.0019 17.5 0.1 2.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCL99695.1 - 3.7e-06 26.8 0.0 0.0075 15.9 0.0 2.9 1 1 1 3 3 3 2 alpha/beta hydrolase fold DLH PF01738.18 CCL99695.1 - 0.00012 21.7 0.1 0.00044 19.9 0.1 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family LIP PF03583.14 CCL99695.1 - 0.00042 19.7 0.0 0.0032 16.9 0.0 2.2 2 0 0 2 2 2 1 Secretory lipase Abhydrolase_2 PF02230.16 CCL99695.1 - 0.0031 17.3 0.0 0.24 11.2 0.0 2.2 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 CCL99695.1 - 0.0036 17.0 0.0 0.0076 15.9 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 CCL99695.1 - 0.21 10.2 0.0 4.8 5.8 0.0 2.2 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Nup35_RRM PF05172.13 CCL99696.1 - 8.6e-09 35.3 0.0 2.6e-08 33.7 0.0 1.7 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 CCL99696.1 - 0.00014 21.8 0.0 0.00056 19.9 0.1 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF1897 PF09005.10 CCL99696.1 - 0.14 11.7 1.0 0.57 9.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1897) TPR_10 PF13374.6 CCL99697.1 - 1.3e-11 44.0 1.1 1.8 8.5 0.0 9.1 10 0 0 10 10 10 5 Tetratricopeptide repeat KxDL PF10241.9 CCL99697.1 - 0.12 12.7 0.1 32 4.9 0.0 3.6 3 1 1 4 4 4 0 Uncharacterized conserved protein Peptidase_C14 PF00656.22 CCL99698.1 - 4.6e-12 46.4 0.0 7e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Caspase domain SwrA PF17423.2 CCL99698.1 - 0.003 17.5 7.6 26 4.8 0.0 5.6 3 2 3 6 6 6 2 Swarming motility protein DUF4372 PF14294.6 CCL99698.1 - 1 9.5 3.1 17 5.6 0.1 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4372) Pkinase_fungal PF17667.1 CCL99699.1 - 2.9e-55 187.7 0.0 1.5e-54 185.3 0.0 1.9 1 1 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCL99699.1 - 2.4e-10 40.2 0.0 5.1e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99699.1 - 3e-07 30.0 0.0 1e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CCL99699.1 - 0.00045 20.2 0.3 0.0051 16.8 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCL99699.1 - 0.0021 17.4 0.1 0.0039 16.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CCL99699.1 - 0.0078 15.8 0.0 0.091 12.3 0.0 2.4 3 0 0 3 3 3 1 Choline/ethanolamine kinase RIO1 PF01163.22 CCL99699.1 - 0.049 13.2 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Peptidase_C14 PF00656.22 CCL99700.1 - 7.5e-14 52.3 0.0 1.5e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 Caspase domain TPR_10 PF13374.6 CCL99700.1 - 0.00033 20.4 0.1 15 5.6 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 CCL99700.1 - 0.007 16.0 0.9 12 5.7 0.0 3.8 3 0 0 3 3 3 1 Fis1 N-terminal tetratricopeptide repeat PTB PF08416.13 CCL99700.1 - 0.019 15.1 2.9 1 9.6 0.0 3.2 3 0 0 3 3 3 0 Phosphotyrosine-binding domain SwrA PF17423.2 CCL99700.1 - 0.039 13.9 8.6 6.3 6.8 0.1 5.2 4 2 2 6 6 6 0 Swarming motility protein NOA36 PF06524.12 CCL99700.1 - 9.2 5.5 8.5 20 4.4 8.5 1.5 1 0 0 1 1 1 0 NOA36 protein TPR_10 PF13374.6 CCL99701.1 - 8e-07 28.7 0.1 0.34 10.8 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCL99701.1 - 0.0045 17.3 0.5 0.2 12.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Cation_ATPase_C PF00689.21 CCL99702.1 - 0.14 11.9 12.1 0.53 10.0 12.2 1.9 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus 4HBT PF03061.22 CCL99703.1 - 3e-14 53.1 0.4 4e-14 52.7 0.4 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CCL99703.1 - 0.02 15.1 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 CCL99703.1 - 0.077 13.2 0.0 0.12 12.6 0.0 1.3 1 1 0 1 1 1 0 Thioesterase-like superfamily DER1 PF04511.15 CCL99704.1 - 3.1e-46 157.7 5.1 3.7e-46 157.5 5.1 1.0 1 0 0 1 1 1 1 Der1-like family DUF4436 PF14494.6 CCL99705.1 - 3e-05 23.4 0.7 4.8e-05 22.8 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4436) SET PF00856.28 CCL99706.1 - 1.7e-09 38.3 0.0 3e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 SET domain DPM3 PF08285.11 CCL99706.1 - 1.6 9.0 6.0 4.4 7.6 0.4 3.0 2 1 1 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) PhoLip_ATPase_C PF16212.5 CCL99706.1 - 5.2 6.8 12.3 0.065 13.0 3.3 2.0 1 1 1 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal DUF4504 PF14953.6 CCL99707.1 - 0.062 12.7 0.0 0.11 11.9 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4504) Pro_isomerase PF00160.21 CCL99708.1 - 3.4e-49 167.1 0.0 7.8e-49 166.0 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 CCL99708.1 - 1e-09 38.8 0.3 0.00026 21.7 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCL99708.1 - 0.0098 16.2 0.0 0.32 11.3 0.0 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Mrr_N PF14338.6 CCL99709.1 - 0.034 14.3 0.0 0.039 14.1 0.0 1.1 1 0 0 1 1 1 0 Mrr N-terminal domain His_Phos_1 PF00300.22 CCL99710.1 - 2.6e-31 108.9 0.0 4.9e-31 107.9 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ufd2P_core PF10408.9 CCL99711.1 - 3.5e-224 746.1 0.0 4.2e-224 745.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 CCL99711.1 - 1.1e-27 95.9 0.4 3.5e-27 94.4 0.4 1.9 1 0 0 1 1 1 1 U-box domain Eaf7 PF07904.13 CCL99712.1 - 1.1e-17 64.3 0.0 1.9e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 Ribosomal_L22 PF00237.19 CCL99713.1 - 1.3e-35 121.7 0.1 2e-35 121.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Asp_Glu_race_2 PF14669.6 CCL99713.1 - 0.059 13.0 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative aspartate racemase Oxidored_FMN PF00724.20 CCL99714.1 - 1.2e-67 228.6 0.0 1.5e-67 228.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CCL99714.1 - 0.2 10.7 0.1 0.49 9.4 0.0 1.6 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) RSN1_7TM PF02714.15 CCL99716.1 - 3.1e-30 105.4 24.4 4.6e-20 72.1 11.2 2.2 1 1 1 2 2 2 2 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCL99716.1 - 3.7e-22 79.4 0.0 1.3e-15 58.1 0.0 2.5 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 CCL99716.1 - 0.081 12.8 0.5 3.3 7.6 0.2 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ETC_C1_NDUFA4 PF04800.12 CCL99717.1 - 7.5e-36 122.3 0.2 9.6e-36 121.9 0.2 1.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region RICTOR_N PF14664.6 CCL99718.1 - 1.1e-121 406.3 0.2 2e-121 405.5 0.2 1.4 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 CCL99718.1 - 1.3e-38 130.9 2.8 1.3e-35 121.3 0.2 4.8 3 1 2 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 CCL99718.1 - 1e-33 115.9 0.2 1.6e-32 112.1 0.1 2.9 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 CCL99718.1 - 8.6e-31 106.0 0.1 4.6e-28 97.3 0.1 4.5 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 CCL99718.1 - 1.4e-06 28.3 5.9 3.4e-06 27.1 5.9 1.7 1 0 0 1 1 1 1 Hr1 repeat Lebercilin PF15619.6 CCL99718.1 - 0.045 13.4 3.2 0.1 12.2 3.2 1.5 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease CgtA PF06306.11 CCL99718.1 - 0.1 12.0 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA) Peptidase_M20 PF01546.28 CCL99719.1 - 7.2e-28 97.7 0.0 1.5e-27 96.7 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCL99719.1 - 5.8e-13 48.7 0.1 3.4e-12 46.2 0.1 2.4 2 1 0 2 2 2 1 Peptidase dimerisation domain VWA_N PF08399.11 CCL99719.1 - 0.18 12.3 0.1 0.47 10.9 0.0 1.7 2 0 0 2 2 2 0 VWA N-terminal Mod_r PF07200.13 CCL99720.1 - 4.9e-41 140.2 2.9 5.9e-41 140.0 2.9 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Rootletin PF15035.6 CCL99720.1 - 0.014 15.4 1.8 0.023 14.7 1.8 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion RPAP1_N PF08621.10 CCL99720.1 - 0.091 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 RPAP1-like, N-terminal DUF349 PF03993.12 CCL99720.1 - 0.098 13.0 4.2 0.31 11.4 2.6 2.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) Sod_Cu PF00080.20 CCL99721.1 - 3.6e-45 153.6 1.0 4.4e-45 153.3 1.0 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CHRD PF07452.12 CCL99721.1 - 0.08 13.9 0.6 0.17 12.9 0.6 1.5 1 1 0 1 1 1 0 CHRD domain tRNA_int_end_N2 PF12928.7 CCL99722.1 - 2.1e-23 82.3 0.0 3.7e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 CCL99722.1 - 0.0081 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain Mito_carr PF00153.27 CCL99723.1 - 9.7e-57 188.9 4.8 1.1e-19 70.2 0.1 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 CCL99723.1 - 0.00034 19.9 1.1 1 8.5 0.1 3.2 3 0 0 3 3 3 3 Gammaproteobacterial serine protease Hist_deacetyl PF00850.19 CCL99724.1 - 2.2e-47 162.0 0.8 3.4e-47 161.4 0.8 1.3 1 0 0 1 1 1 1 Histone deacetylase domain zf-rbx1 PF12678.7 CCL99725.1 - 3.1e-07 30.6 5.1 7.4e-07 29.4 5.1 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCL99725.1 - 3.3e-05 24.1 5.7 3.3e-05 24.1 5.7 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCL99725.1 - 0.02 14.7 6.2 0.02 14.7 6.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCL99725.1 - 0.055 13.3 6.9 0.14 12.0 5.6 2.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCL99725.1 - 0.1 12.6 6.1 0.14 12.2 4.0 2.3 2 1 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCL99725.1 - 0.19 11.6 6.3 0.15 11.9 2.2 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CCL99725.1 - 0.21 11.3 0.9 0.52 10.0 0.9 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 CCL99725.1 - 0.21 11.5 5.5 0.96 9.4 1.5 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CCL99725.1 - 0.48 10.5 5.5 4.1 7.5 5.3 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RecR PF02132.15 CCL99725.1 - 2.1 8.0 5.3 0.33 10.6 1.1 1.8 2 0 0 2 2 2 0 RecR protein BSP_II PF05432.11 CCL99725.1 - 2.9 7.5 11.3 0.25 11.0 5.9 1.7 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) RINGv PF12906.7 CCL99725.1 - 5.4 7.2 8.4 0.14 12.3 1.1 2.1 3 0 0 3 3 3 0 RING-variant domain zf-RING_5 PF14634.6 CCL99725.1 - 9.7 6.2 7.7 14 5.8 5.7 2.1 1 1 1 2 2 2 0 zinc-RING finger domain Amidohydro_1 PF01979.20 CCL99726.1 - 1.5e-38 133.0 0.0 1.7e-38 132.8 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCL99726.1 - 8.4e-15 55.2 0.2 2.4e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Histone PF00125.24 CCL99728.1 - 2.5e-49 167.0 3.2 2.8e-49 166.8 3.2 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CCL99728.1 - 2.7e-05 24.5 0.1 4.2e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CCL99728.1 - 8.1e-05 22.7 0.9 0.0001 22.4 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 CCL99728.1 - 0.00087 19.5 1.1 0.0014 18.8 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PAF PF15715.5 CCL99728.1 - 0.0032 18.1 2.0 0.004 17.7 2.0 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain Bromo_TP PF07524.13 CCL99728.1 - 0.085 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 CCL99728.1 - 0.11 12.6 0.3 0.17 11.9 0.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit DAO PF01266.24 CCL99729.1 - 6.1e-52 177.3 0.1 9.8e-52 176.7 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 CCL99729.1 - 5.5e-45 152.3 0.0 1.1e-44 151.4 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 CCL99729.1 - 3.4e-06 26.4 5.6 3.1e-05 23.3 5.6 2.1 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CCL99729.1 - 2.5e-05 23.8 1.0 4.4e-05 23.0 0.3 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCL99729.1 - 0.0017 17.7 0.1 0.0036 16.6 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCL99729.1 - 0.005 17.1 0.3 0.017 15.4 0.3 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CCL99729.1 - 0.011 14.9 0.2 0.057 12.5 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CCL99729.1 - 0.013 14.7 0.7 0.11 11.7 0.8 2.0 1 1 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CCL99729.1 - 0.03 14.9 0.2 0.078 13.6 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCL99729.1 - 0.031 14.2 0.1 0.061 13.2 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 CCL99729.1 - 0.041 12.6 0.7 0.062 12.0 0.7 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 CCL99729.1 - 0.097 11.9 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CCL99729.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RhoGAP PF00620.27 CCL99730.1 - 4.5e-33 114.2 0.0 7.7e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 CCL99730.1 - 1.6e-30 106.1 0.1 3.1e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 CCL99730.1 - 3.6e-05 23.5 0.3 0.00011 21.9 0.2 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain bZIP_2 PF07716.15 CCL99731.1 - 3.3e-07 30.3 12.8 6.4e-07 29.4 12.8 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CCL99731.1 - 0.00069 19.7 9.4 0.0013 18.8 9.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 CCL99731.1 - 0.011 16.3 4.7 0.02 15.4 4.7 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor AKNA PF12443.8 CCL99731.1 - 0.25 12.0 2.2 0.36 11.5 0.2 2.3 2 0 0 2 2 2 0 AT-hook-containing transcription factor GST_N PF02798.20 CCL99732.1 - 1.8e-20 73.1 0.0 3.5e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCL99732.1 - 9.1e-14 51.5 0.0 2e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCL99732.1 - 7.5e-13 48.5 0.0 1.3e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCL99732.1 - 1.8e-12 47.5 0.0 3.1e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCL99732.1 - 6.4e-09 35.9 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCL99732.1 - 3.7e-06 26.9 0.2 8.2e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain F-box-like PF12937.7 CCL99733.1 - 1.5e-05 24.8 0.8 3.5e-05 23.6 0.8 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCL99733.1 - 0.018 14.9 0.1 0.071 13.0 0.0 2.0 2 0 0 2 2 2 0 F-box domain TAF PF02969.17 CCL99734.1 - 1.1e-21 76.8 0.5 2.1e-21 75.9 0.5 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 CCL99734.1 - 5e-15 55.6 0.1 1.3e-14 54.2 0.1 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain Histone PF00125.24 CCL99734.1 - 3.4e-05 24.2 0.8 7.1e-05 23.2 0.8 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 CCL99734.1 - 0.0086 16.1 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 CCL99734.1 - 0.07 13.4 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CCL99734.1 - 0.095 12.8 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 CCL99734.1 - 0.15 12.4 0.2 0.31 11.5 0.2 1.4 1 0 0 1 1 1 0 CENP-S protein FMN_dh PF01070.18 CCL99735.1 - 3.4e-115 384.8 0.0 4.2e-115 384.5 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCL99735.1 - 1.5e-20 73.1 0.0 3.6e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NMO PF03060.15 CCL99735.1 - 0.00011 21.7 0.0 0.0002 20.9 0.0 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 CCL99735.1 - 0.0011 18.2 0.1 0.0021 17.3 0.1 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCL99735.1 - 0.0017 17.4 0.0 0.003 16.6 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain DUF4148 PF13663.6 CCL99735.1 - 0.21 11.8 1.5 0.69 10.1 1.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) Oxidored_molyb PF00174.19 CCL99737.1 - 5.6e-49 166.0 0.0 5.6e-48 162.8 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CCL99737.1 - 7.1e-21 74.7 1.9 1.3e-20 73.9 1.9 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain IBN_N PF03810.19 CCL99738.1 - 9.9e-11 41.4 0.0 1.2e-07 31.6 0.0 3.2 3 0 0 3 3 3 2 Importin-beta N-terminal domain MIF4G_like PF09088.11 CCL99738.1 - 0.0012 18.6 0.1 0.0046 16.7 0.1 2.0 1 0 0 1 1 1 1 MIF4G like Cnd3 PF12719.7 CCL99738.1 - 0.0026 17.0 0.3 0.0026 17.0 0.3 2.3 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain Adaptin_N PF01602.20 CCL99738.1 - 0.0027 16.4 0.5 0.42 9.1 0.2 2.5 2 0 0 2 2 2 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 CCL99738.1 - 0.005 17.4 0.1 1 10.0 0.0 3.8 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 CCL99738.1 - 0.0052 16.6 1.3 0.021 14.6 0.1 2.5 2 1 0 2 2 2 1 rRNA processing/ribosome biogenesis Cse1 PF08506.10 CCL99738.1 - 0.0075 15.1 0.0 0.021 13.7 0.0 1.8 1 0 0 1 1 1 1 Cse1 HEAT_2 PF13646.6 CCL99738.1 - 0.02 15.3 0.6 1 9.8 0.0 3.7 4 0 0 4 4 3 0 HEAT repeats Cnd1 PF12717.7 CCL99738.1 - 0.025 14.6 1.0 0.099 12.7 0.5 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Xpo1 PF08389.12 CCL99738.1 - 0.036 14.1 4.4 0.06 13.4 0.0 3.6 4 1 0 4 4 4 0 Exportin 1-like protein Thiamine_BP PF01910.17 CCL99738.1 - 0.13 12.2 0.2 0.31 11.0 0.2 1.6 1 0 0 1 1 1 0 Thiamine-binding protein RTP1_C1 PF10363.9 CCL99738.1 - 0.13 12.5 0.2 0.81 9.9 0.1 2.4 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF2407_C PF13373.6 CCL99739.1 - 2.1e-18 66.9 2.0 1.4e-17 64.1 2.0 2.2 1 1 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 CCL99739.1 - 2.6e-17 63.3 0.1 4.2e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 CCL99739.1 - 0.0001 22.0 0.0 0.00019 21.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCL99739.1 - 0.064 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Kin17_mid PF10357.9 CCL99740.1 - 1.8e-50 170.1 0.9 2.9e-50 169.4 0.9 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 CCL99740.1 - 0.00027 21.2 6.3 0.00065 20.0 6.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCL99740.1 - 0.015 15.6 5.1 0.034 14.4 5.1 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CCL99740.1 - 0.021 15.2 0.9 0.021 15.2 0.9 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Actin PF00022.19 CCL99741.1 - 1.1e-63 215.3 0.0 1.6e-62 211.4 0.0 1.9 1 1 0 1 1 1 1 Actin TANGO2 PF05742.12 CCL99742.1 - 3.4e-41 142.0 0.0 4.6e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Zn_clus PF00172.18 CCL99743.1 - 1.6e-08 34.5 7.3 3.2e-08 33.6 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSS PF03034.15 CCL99744.1 - 1.5e-114 382.4 12.7 2e-114 382.0 12.7 1.1 1 0 0 1 1 1 1 Phosphatidyl serine synthase TMEM169 PF15052.6 CCL99744.1 - 0.45 10.6 6.4 1 9.5 2.5 2.6 2 0 0 2 2 2 0 TMEM169 protein family zf-RING_2 PF13639.6 CCL99745.1 - 1.1e-10 41.6 13.2 9.6e-07 29.0 3.9 3.5 3 0 0 3 3 3 2 Ring finger domain zf-rbx1 PF12678.7 CCL99745.1 - 7.8e-06 26.1 1.8 7.8e-06 26.1 1.8 3.8 4 1 0 4 4 3 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CCL99745.1 - 1.6e-05 24.8 9.3 0.035 14.1 7.3 3.1 2 1 0 2 2 2 2 RING-type zinc-finger zf-RING_11 PF17123.5 CCL99745.1 - 2.1e-05 24.2 11.6 0.00087 19.0 1.0 3.5 3 0 0 3 3 3 2 RING-like zinc finger zf-RING_5 PF14634.6 CCL99745.1 - 0.00021 21.2 10.3 0.025 14.5 1.9 3.3 3 0 0 3 3 3 2 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CCL99745.1 - 0.00025 20.6 7.4 0.00077 19.0 2.0 2.6 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 CCL99745.1 - 0.00093 19.0 12.4 0.0078 16.1 4.9 3.1 2 2 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCL99745.1 - 0.0068 16.4 0.7 0.0068 16.4 0.7 3.1 3 1 0 3 3 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 CCL99745.1 - 0.008 16.0 16.9 0.015 15.2 5.4 3.7 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCL99745.1 - 0.06 13.2 11.8 0.033 14.1 1.9 3.3 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 FANCL_C PF11793.8 CCL99745.1 - 0.072 13.3 5.1 2.7 8.2 0.5 3.0 3 0 0 3 3 2 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 CCL99745.1 - 0.09 12.7 6.6 0.07 13.0 0.9 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Zf_RING PF16744.5 CCL99745.1 - 1.2 9.3 3.4 6.2 7.0 0.2 2.5 3 0 0 3 3 2 0 KIAA1045 RING finger SelP_N PF04592.14 CCL99745.1 - 4.6 6.6 14.6 12 5.2 14.6 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PHD PF00628.29 CCL99745.1 - 8.6 6.3 12.3 12 5.9 2.2 2.9 2 1 0 2 2 2 0 PHD-finger zf-C3HC4_4 PF15227.6 CCL99745.1 - 9.4 6.5 15.1 0.12 12.6 1.3 3.5 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Nop PF01798.18 CCL99748.1 - 1.9e-82 276.2 0.0 1.9e-82 276.2 0.0 1.8 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CCL99748.1 - 1.6e-20 73.3 0.5 1.6e-20 73.3 0.5 2.1 2 0 0 2 2 2 1 NOP5NT (NUC127) domain MRP-S27 PF10037.9 CCL99748.1 - 6.6 5.5 13.7 12 4.6 13.7 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Na_H_Exchanger PF00999.21 CCL99749.1 - 7.2e-51 173.2 50.5 1e-50 172.6 50.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family GDA1_CD39 PF01150.17 CCL99750.1 - 5.7e-91 305.3 0.0 7.7e-91 304.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family p450 PF00067.22 CCL99751.1 - 4.4e-66 223.5 0.0 2.7e-65 220.9 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 His_Phos_2 PF00328.22 CCL99752.1 - 9.5e-49 166.7 0.0 1.3e-48 166.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) adh_short PF00106.25 CCL99753.1 - 3.6e-29 101.6 0.0 4.9e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99753.1 - 3.6e-22 79.1 0.0 4.4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCL99753.1 - 5.3e-09 36.2 0.0 7.5e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCL99753.1 - 2.5e-06 27.5 0.0 3.5e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCL99753.1 - 0.00055 19.5 0.0 0.0029 17.1 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCL99753.1 - 0.085 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCL99754.1 - 6.9e-50 169.2 0.0 3.5e-29 101.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99754.1 - 2.4e-42 145.1 0.0 2.5e-23 82.8 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCL99754.1 - 6.4e-07 29.5 0.0 6.1e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CCL99754.1 - 1.2e-05 25.3 0.1 0.00047 20.1 0.0 2.3 2 0 0 2 2 2 1 NAD(P)H-binding DUF1776 PF08643.10 CCL99754.1 - 0.011 15.1 0.0 4.7 6.5 0.0 2.2 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCL99754.1 - 0.013 14.9 0.0 0.19 11.1 0.0 2.5 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCL99754.1 - 0.083 12.0 0.0 3.4 6.8 0.0 2.9 2 1 0 3 3 3 0 Male sterility protein F-box-like PF12937.7 CCL99756.1 - 1.6e-05 24.7 0.9 7.3e-05 22.6 0.9 2.3 1 0 0 1 1 1 1 F-box-like Mu-like_Com PF10122.9 CCL99756.1 - 0.12 11.8 0.5 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Mu-like prophage protein Com DUF4787 PF16029.5 CCL99756.1 - 0.15 12.2 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4787) FAD_binding_3 PF01494.19 CCL99757.1 - 3.6e-76 256.7 0.0 4.8e-76 256.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCL99757.1 - 3.5e-06 26.5 1.8 0.00098 18.4 0.3 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCL99757.1 - 0.00027 21.4 0.3 0.21 12.1 0.1 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCL99757.1 - 0.00027 20.6 1.1 0.001 18.7 0.7 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCL99757.1 - 0.00031 19.9 0.4 0.00069 18.8 0.2 1.7 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 CCL99757.1 - 0.00051 19.4 0.1 0.00091 18.5 0.1 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CCL99757.1 - 0.00053 20.2 0.1 0.0016 18.6 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCL99757.1 - 0.00084 18.2 1.2 0.008 14.9 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 CCL99757.1 - 0.0018 17.6 0.2 0.0031 16.8 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CCL99757.1 - 0.026 14.2 0.1 0.06 13.0 0.1 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 CCL99757.1 - 0.066 12.5 0.1 0.43 9.9 0.1 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCL99757.1 - 0.089 11.8 1.1 0.12 11.4 0.3 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 CCL99757.1 - 0.17 11.9 1.2 0.4 10.7 0.5 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding AAA PF00004.29 CCL99759.1 - 3.5e-79 263.7 0.0 1.8e-41 141.6 0.0 3.5 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCL99759.1 - 6.5e-23 80.3 4.0 1e-12 47.7 0.3 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CCL99759.1 - 2.7e-12 47.4 5.9 5.5e-07 30.1 0.2 4.4 3 2 1 4 4 3 2 AAA ATPase domain RuvB_N PF05496.12 CCL99759.1 - 1.6e-10 41.0 0.0 0.00079 19.2 0.0 3.4 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CCL99759.1 - 9.3e-10 38.6 0.1 2.5e-05 24.3 0.0 3.6 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CCL99759.1 - 7.3e-08 32.7 0.0 0.00021 21.5 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCL99759.1 - 4.8e-07 30.1 0.0 0.0045 17.3 0.0 3.5 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CCL99759.1 - 3.4e-06 26.9 0.0 0.00054 19.7 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein TsaE PF02367.17 CCL99759.1 - 1.8e-05 24.8 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 CCL99759.1 - 4.9e-05 23.5 0.0 0.0021 18.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 CCL99759.1 - 5.1e-05 22.6 0.0 0.041 13.1 0.0 2.7 3 0 0 3 3 3 1 TIP49 P-loop domain AAA_11 PF13086.6 CCL99759.1 - 6.3e-05 22.9 0.0 0.0085 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCL99759.1 - 0.00028 21.3 0.0 0.13 12.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 CCL99759.1 - 0.00028 20.5 0.6 2 7.9 0.1 3.5 2 1 1 3 3 3 1 AAA domain Mg_chelatase PF01078.21 CCL99759.1 - 0.00072 19.0 0.3 0.33 10.3 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CCL99759.1 - 0.00081 19.7 0.0 0.075 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CCL99759.1 - 0.0015 17.9 0.0 0.072 12.4 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_7 PF12775.7 CCL99759.1 - 0.0016 18.0 0.0 0.83 9.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Vps4_C PF09336.10 CCL99759.1 - 0.0019 18.2 0.1 0.12 12.3 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Bac_DnaA PF00308.18 CCL99759.1 - 0.0022 17.9 0.1 0.66 9.8 0.0 3.0 3 0 0 3 3 3 1 Bacterial dnaA protein NACHT PF05729.12 CCL99759.1 - 0.0024 17.8 0.2 0.082 12.8 0.0 3.0 2 1 0 2 2 2 1 NACHT domain AAA_3 PF07726.11 CCL99759.1 - 0.0045 16.8 0.1 3.3 7.6 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCL99759.1 - 0.006 16.5 0.0 0.24 11.3 0.0 2.6 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_18 PF13238.6 CCL99759.1 - 0.006 17.1 0.0 0.037 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCL99759.1 - 0.011 15.4 0.0 0.095 12.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 CCL99759.1 - 0.016 14.4 0.0 1.8 7.6 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF815) PhoH PF02562.16 CCL99759.1 - 0.029 13.8 0.1 0.21 11.0 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 CCL99759.1 - 0.031 14.0 0.0 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CCL99759.1 - 0.035 14.1 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCL99759.1 - 0.06 13.9 0.1 1.4 9.5 0.0 2.6 2 1 1 3 3 3 0 ABC transporter ATPase PF06745.13 CCL99759.1 - 0.066 12.6 0.0 4.6 6.5 0.0 2.4 2 0 0 2 2 2 0 KaiC AAA_19 PF13245.6 CCL99759.1 - 0.067 13.5 1.5 0.75 10.1 0.0 2.8 4 0 0 4 4 2 0 AAA domain DAP3 PF10236.9 CCL99759.1 - 0.068 12.3 0.0 0.23 10.6 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Sigma54_activat PF00158.26 CCL99759.1 - 0.081 12.6 0.0 0.74 9.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AFG1_ATPase PF03969.16 CCL99759.1 - 0.12 11.3 0.0 0.86 8.4 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase Adeno_IVa2 PF02456.15 CCL99759.1 - 0.17 10.7 0.1 4.9 5.9 0.0 2.8 3 0 0 3 3 3 0 Adenovirus IVa2 protein Parvo_NS1 PF01057.17 CCL99759.1 - 0.17 11.0 0.0 0.41 9.7 0.0 1.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Gpi16 PF04113.14 CCL99760.1 - 1e-136 456.6 0.0 1.3e-136 456.3 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component AA_permease PF00324.21 CCL99761.1 - 3e-76 257.0 40.1 9.5e-73 245.4 24.2 2.9 2 1 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 CCL99761.1 - 1.7e-30 106.2 23.4 8.6e-30 103.9 23.4 1.9 1 1 0 1 1 1 1 Amino acid permease F1F0-ATPsyn_F PF10791.9 CCL99761.1 - 5e-27 94.2 0.0 1.4e-26 92.7 0.0 1.8 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi NCE101 PF11654.8 CCL99761.1 - 0.18 11.6 0.2 0.43 10.3 0.2 1.6 1 0 0 1 1 1 0 Non-classical export protein 1 LapA_dom PF06305.11 CCL99762.1 - 3.1 7.7 7.5 1.5 8.7 2.3 3.0 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Coprogen_oxidas PF01218.18 CCL99763.1 - 7.2e-127 422.2 0.0 8.3e-127 422.0 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF4795 PF16043.5 CCL99763.1 - 0.26 10.9 0.0 0.39 10.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF3519 PF12033.8 CCL99765.1 - 0.072 13.5 1.2 0.12 12.8 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3519) Adeno_E3_CR2 PF02439.15 CCL99766.1 - 0.0066 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 H_PPase PF03030.16 CCL99766.1 - 0.054 12.1 0.7 0.072 11.7 0.7 1.1 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase Syndecan PF01034.20 CCL99766.1 - 0.075 13.0 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain SKG6 PF08693.10 CCL99766.1 - 0.12 11.9 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EphA2_TM PF14575.6 CCL99766.1 - 0.13 13.1 0.0 0.23 12.4 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EB1 PF03271.17 CCL99767.1 - 1.1e-15 57.6 2.0 2.1e-15 56.7 2.0 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 CCL99767.1 - 3.8e-05 23.8 1.0 6.9e-05 23.0 0.1 1.8 2 0 0 2 2 2 1 Calponin homology (CH) domain F-box-like PF12937.7 CCL99768.1 - 6.6e-08 32.3 0.1 1.4e-07 31.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like Chitin_synth_1 PF01644.17 CCL99770.1 - 1.3e-80 269.1 0.1 1.9e-80 268.5 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCL99770.1 - 2.4e-28 97.9 0.0 8.3e-28 96.2 0.0 1.9 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCL99770.1 - 5.5e-23 81.4 0.1 1.1e-16 60.6 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase MFS_1 PF07690.16 CCL99770.1 - 1e-12 47.7 68.4 2.9e-09 36.3 34.5 4.6 3 2 1 4 4 4 2 Major Facilitator Superfamily Glyco_trans_2_3 PF13632.6 CCL99770.1 - 7.4e-05 22.7 2.8 7.4e-05 22.7 2.8 3.4 2 1 1 3 3 3 1 Glycosyl transferase family group 2 HPD PF05044.12 CCL99770.1 - 7.9 6.3 5.6 5.7 6.8 3.3 1.8 2 0 0 2 2 2 0 Homeo-prospero domain DUF5345 PF17280.2 CCL99771.1 - 0.13 12.3 0.2 16 5.6 0.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Wzy_C PF04932.15 CCL99773.1 - 0.096 12.3 2.1 1.2 8.7 2.1 2.2 1 1 0 1 1 1 0 O-Antigen ligase MatE PF01554.18 CCL99774.1 - 7.4e-50 168.7 28.2 7.7e-25 87.4 11.9 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 CCL99774.1 - 1.3e-07 31.8 8.3 1.3e-07 31.8 8.3 4.1 3 3 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Metallophos PF00149.28 CCL99776.1 - 5.8e-13 49.8 1.4 2.6e-12 47.7 1.4 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase RRM_1 PF00076.22 CCL99779.1 - 2.7e-09 36.7 0.0 9.3e-06 25.4 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCL99779.1 - 0.046 13.8 0.0 4.6 7.4 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif PGI PF00342.19 CCL99780.1 - 9.4e-230 763.3 0.1 1.3e-229 762.8 0.1 1.2 1 0 0 1 1 1 1 Phosphoglucose isomerase PCI PF01399.27 CCL99781.1 - 6.3e-06 26.7 0.1 2.4e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 PCI domain Piwi PF02171.17 CCL99782.1 - 9.5e-61 205.7 0.0 1.4e-60 205.1 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CCL99782.1 - 2.4e-17 63.8 0.0 4.6e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CCL99782.1 - 1.2e-14 53.7 0.0 2.8e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoMid PF16487.5 CCL99782.1 - 1.3e-13 51.0 0.2 3.5e-13 49.6 0.2 1.7 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 CCL99782.1 - 2.4e-12 47.0 0.1 6.5e-12 45.6 0.1 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 CCL99782.1 - 1.8e-08 34.3 0.0 3.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 PAZ domain Solute_trans_a PF03619.16 CCL99783.1 - 3e-90 302.4 11.6 4e-90 301.9 11.6 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DPM3 PF08285.11 CCL99783.1 - 0.0026 17.9 3.0 0.0089 16.2 3.0 1.9 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Tab2_like PF06485.11 CCL99783.1 - 0.046 13.2 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 DUF3332 PF11810.8 CCL99783.1 - 0.073 12.7 0.3 0.13 11.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) Cys_Met_Meta_PP PF01053.20 CCL99784.1 - 5.6e-123 410.3 0.0 1e-121 406.1 0.0 2.0 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 CCL99784.1 - 0.00072 18.2 0.0 0.00095 17.8 0.0 1.1 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_1_2 PF00155.21 CCL99784.1 - 0.0044 16.2 0.0 0.008 15.4 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Tocopherol_cycl PF14249.6 CCL99785.1 - 2.6e-06 26.8 1.1 2.5e-05 23.5 0.1 2.5 3 0 0 3 3 3 1 Tocopherol cyclase eIF3g PF12353.8 CCL99786.1 - 5.1e-44 149.7 2.2 7.1e-44 149.2 2.2 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 CCL99786.1 - 1.8e-17 62.9 0.0 3.4e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OAM_alpha PF16552.5 CCL99786.1 - 0.026 14.4 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 D-ornithine 4,5-aminomutase alpha-subunit RRM_3 PF08777.11 CCL99786.1 - 0.086 12.9 0.3 2 8.5 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif HET PF06985.11 CCL99787.1 - 2.3e-10 41.0 1.0 7.4e-07 29.6 0.0 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) FMN_red PF03358.15 CCL99788.1 - 2.7e-09 36.9 0.0 4e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CCL99788.1 - 3.4e-05 23.7 0.0 4.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 CCL99788.1 - 0.00016 21.9 0.4 0.0029 17.8 0.4 2.2 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 CCL99788.1 - 0.014 15.6 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain Mito_carr PF00153.27 CCL99790.1 - 7.7e-57 189.2 0.5 1.3e-20 73.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Thymopoietin PF08198.11 CCL99790.1 - 0.17 11.5 0.5 5.1 6.8 0.1 2.8 3 0 0 3 3 3 0 Thymopoietin protein MutS_V PF00488.21 CCL99791.1 - 1.2e-83 279.8 0.1 2.9e-83 278.6 0.1 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCL99791.1 - 3.8e-35 121.9 1.5 3.8e-35 121.9 1.5 2.0 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 CCL99791.1 - 7.4e-18 64.7 1.6 7.4e-18 64.7 1.6 2.1 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 CCL99791.1 - 7.9e-16 58.6 0.5 1.1e-14 54.8 0.0 3.0 3 0 0 3 3 3 1 MutS domain II MutS_I PF01624.20 CCL99791.1 - 2.3e-09 37.5 0.0 6.1e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 MutS domain I Birna_RdRp PF04197.12 CCL99791.1 - 0.03 12.7 0.0 0.051 11.9 0.0 1.2 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) AAA_23 PF13476.6 CCL99791.1 - 0.36 11.3 6.4 12 6.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain Pmp3 PF01679.17 CCL99792.1 - 2.6e-24 85.2 12.1 4e-24 84.6 12.1 1.3 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RRF PF01765.19 CCL99793.1 - 8.6e-26 90.8 0.4 2.3e-25 89.4 0.1 1.7 1 1 1 2 2 2 1 Ribosome recycling factor RR_TM4-6 PF06459.12 CCL99794.1 - 7.1 6.4 8.2 0.75 9.6 3.6 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 IBR PF01485.21 CCL99795.1 - 6.1e-14 52.0 31.8 7.7e-09 35.7 4.1 4.5 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain RRM_1 PF00076.22 CCL99795.1 - 9.4e-11 41.4 0.0 1.8e-08 34.1 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 CCL99795.1 - 5.1e-09 35.8 24.0 1e-05 25.3 2.0 3.8 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_4 PF15227.6 CCL99795.1 - 1.7e-07 31.3 4.2 1.7e-07 31.3 4.2 4.3 4 1 1 5 5 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCL99795.1 - 1.9e-07 31.0 5.3 1.9e-07 31.0 5.3 3.3 2 1 0 2 2 2 1 RING-type zinc-finger Torus PF16131.5 CCL99795.1 - 5.3e-07 30.3 6.1 0.063 14.0 0.6 3.6 3 0 0 3 3 3 3 Torus domain zf-C3HC4_2 PF13923.6 CCL99795.1 - 1.7e-06 27.7 2.1 1.7e-06 27.7 2.1 3.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCL99795.1 - 2.8e-06 27.1 3.4 2.8e-06 27.1 3.4 3.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCL99795.1 - 5.1e-05 23.1 1.6 5.1e-05 23.1 1.6 4.8 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCL99795.1 - 5.8e-05 23.3 4.0 5.8e-05 23.3 4.0 4.8 5 0 0 5 5 3 1 Ring finger domain zf-CCCH_3 PF15663.5 CCL99795.1 - 0.00077 19.7 4.3 0.037 14.3 0.1 3.3 3 0 0 3 3 3 1 Zinc-finger containing family zf-RING_5 PF14634.6 CCL99795.1 - 0.0023 17.8 4.1 0.0023 17.8 4.1 4.1 2 1 0 2 2 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 CCL99795.1 - 0.4 10.5 6.5 0.52 10.1 2.6 3.0 3 0 0 3 3 3 0 RING-like zinc finger zf-RING_14 PF17978.1 CCL99795.1 - 3.2 8.2 8.0 0.48 10.9 0.5 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf_CCCH_4 PF18345.1 CCL99795.1 - 5.7 7.1 41.8 0.044 13.9 4.9 4.8 6 0 0 6 6 5 0 Zinc finger domain GIDA_assoc PF13932.6 CCL99796.1 - 0.047 13.9 2.0 0.047 13.9 0.4 1.7 2 0 0 2 2 2 0 GidA associated domain ATP-cone PF03477.16 CCL99796.1 - 0.23 12.1 1.2 0.53 10.9 0.3 2.0 2 1 0 2 2 2 0 ATP cone domain AdoHcyase PF05221.17 CCL99797.1 - 7.9e-133 442.2 0.0 6e-73 245.6 0.3 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CCL99797.1 - 4.7e-82 273.9 0.7 7e-82 273.3 0.7 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CCL99797.1 - 6.2e-08 32.2 0.0 1.1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCL99797.1 - 0.0019 18.4 0.0 0.0043 17.3 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.12 CCL99797.1 - 0.0042 16.7 0.1 0.0072 15.9 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 CCL99797.1 - 0.022 14.6 0.3 0.044 13.7 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CCL99797.1 - 0.043 14.3 0.1 0.11 12.9 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding F420_oxidored PF03807.17 CCL99797.1 - 0.057 14.0 0.2 0.12 13.0 0.2 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ELFV_dehydrog PF00208.21 CCL99797.1 - 0.073 12.8 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Ank_4 PF13637.6 CCL99798.1 - 1.1e-05 25.9 0.0 0.0033 18.0 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Lyase_1 PF00206.20 CCL99800.1 - 6.8e-21 75.0 0.1 1.6e-11 44.2 0.0 2.2 1 1 1 2 2 2 2 Lyase ADSL_C PF10397.9 CCL99800.1 - 8.3e-20 71.1 0.0 2e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Pkinase PF00069.25 CCL99801.1 - 1.7e-68 230.9 0.0 2.4e-68 230.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99801.1 - 4.9e-38 130.9 0.0 7.5e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCL99801.1 - 7.2e-07 28.8 0.1 3.4e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like KA1 PF02149.19 CCL99801.1 - 0.0007 19.3 0.0 0.0015 18.2 0.0 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 CCL99801.1 - 0.0063 15.5 0.4 0.01 14.8 0.4 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 CCL99801.1 - 0.022 14.3 0.1 0.046 13.3 0.1 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CCL99801.1 - 0.07 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCL99801.1 - 1 8.1 2.6 0.61 8.8 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase HEM4 PF02602.15 CCL99803.1 - 3.1e-36 124.9 0.0 3.5e-36 124.7 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD DUF2752 PF10825.8 CCL99803.1 - 0.19 11.8 0.2 2.4 8.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2752) Integrase_H2C2 PF17921.1 CCL99804.1 - 2.1e-09 37.3 0.7 8.6e-09 35.4 1.2 1.7 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CCL99804.1 - 0.0041 17.3 0.0 0.0094 16.2 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger SSF PF00474.17 CCL99805.1 - 2.7e-24 85.8 34.5 3.9e-24 85.3 34.5 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Mito_carr PF00153.27 CCL99806.1 - 3.9e-62 206.2 6.1 3.9e-21 74.8 0.4 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.21 CCL99807.1 - 2.4e-47 161.5 0.0 3e-47 161.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IATP PF04568.12 CCL99808.1 - 2.1e-08 34.5 5.2 2.4e-08 34.3 5.2 1.2 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF4140 PF13600.6 CCL99808.1 - 0.00027 21.3 2.4 0.0003 21.2 2.4 1.1 1 0 0 1 1 1 1 N-terminal domain of unknown function (DUF4140) YgaB PF14182.6 CCL99808.1 - 0.0039 17.5 4.4 0.0051 17.2 4.4 1.2 1 0 0 1 1 1 1 YgaB-like protein CRA PF06589.11 CCL99808.1 - 0.15 12.2 5.1 0.19 11.8 5.1 1.1 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) ATP_sub_h PF10775.9 CCL99809.1 - 9.3e-24 83.2 0.7 1.3e-23 82.7 0.7 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h Histone PF00125.24 CCL99810.1 - 2.7e-19 69.8 0.0 3.5e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CCL99810.1 - 1.3e-06 28.0 0.2 1.3e-06 28.0 0.2 1.9 2 1 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CCL99810.1 - 0.0091 16.3 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RNA_pol PF00940.19 CCL99811.1 - 6.3e-182 605.0 0.0 8.2e-182 604.6 0.0 1.1 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CCL99811.1 - 3.8e-96 322.4 1.1 5.6e-96 321.8 1.1 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal PPR_2 PF13041.6 CCL99811.1 - 0.081 13.1 0.0 0.34 11.1 0.0 2.1 2 0 0 2 2 2 0 PPR repeat family DUF5586 PF17824.1 CCL99811.1 - 0.25 10.4 4.5 0.038 13.1 0.4 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5586) SUR7 PF06687.12 CCL99812.1 - 0.00016 21.4 23.0 0.0048 16.6 22.7 2.4 1 1 0 1 1 1 1 SUR7/PalI family Atthog PF18800.1 CCL99812.1 - 0.015 15.2 2.7 0.015 15.2 2.7 2.9 2 2 0 2 2 2 0 Attenuator of Hedgehog Trp_oprn_chp PF09534.10 CCL99812.1 - 0.082 12.7 0.1 0.082 12.7 0.1 2.0 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SLATT_1 PF18181.1 CCL99812.1 - 0.42 10.5 2.0 1 9.3 2.0 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 DuoxA PF10204.9 CCL99812.1 - 5.8 5.8 9.1 0.8 8.7 4.7 1.6 2 0 0 2 2 2 0 Dual oxidase maturation factor CsbD PF05532.12 CCL99813.1 - 0.00028 20.7 7.9 0.00082 19.2 7.9 1.8 1 0 0 1 1 1 1 CsbD-like BTB PF00651.31 CCL99814.1 - 1.1e-21 77.1 0.4 3.6e-09 36.8 0.1 3.3 4 0 0 4 4 4 2 BTB/POZ domain Skp1_POZ PF03931.15 CCL99814.1 - 0.014 15.5 0.3 6.3 7.0 0.1 2.6 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Adaptin_N PF01602.20 CCL99815.1 - 3.1e-138 461.6 7.4 4e-138 461.2 7.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCL99815.1 - 2e-59 200.3 1.7 2e-59 200.3 1.7 2.8 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCL99815.1 - 1.3e-18 67.2 3.7 2.6e-08 34.1 0.1 6.4 3 3 3 6 6 6 5 HEAT repeats HEAT PF02985.22 CCL99815.1 - 3.2e-08 33.1 15.6 0.00031 20.7 0.1 6.6 8 0 0 8 8 8 3 HEAT repeat HEAT_EZ PF13513.6 CCL99815.1 - 6e-05 23.5 2.9 0.38 11.3 0.1 5.9 4 2 2 6 6 6 1 HEAT-like repeat CLASP_N PF12348.8 CCL99815.1 - 0.0011 18.6 0.3 0.39 10.2 0.0 3.5 2 1 1 3 3 3 1 CLASP N terminal RTP1_C1 PF10363.9 CCL99815.1 - 0.0013 18.9 2.5 0.67 10.2 0.0 4.5 2 2 2 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 TIP120 PF08623.10 CCL99815.1 - 0.011 15.5 4.0 0.64 9.8 0.0 3.3 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) FAD_binding_1 PF00667.20 CCL99816.1 - 1.5e-38 132.6 0.0 2.4e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CCL99816.1 - 9.9e-26 90.7 0.0 2.3e-25 89.5 0.0 1.6 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 CCL99816.1 - 9.2e-09 35.9 0.0 2e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 CCL99816.1 - 0.024 14.9 0.2 0.057 13.7 0.2 1.6 1 0 0 1 1 1 0 Flavodoxin domain SNase PF00565.17 CCL99817.1 - 8.7e-16 58.3 0.0 1.2e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Beta-lactamase PF00144.24 CCL99818.1 - 3.5e-43 148.1 0.1 5.4e-43 147.5 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 CCL99818.1 - 0.001 19.5 0.0 0.0023 18.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Beta-lactamase PF00144.24 CCL99820.1 - 3.6e-38 131.7 0.4 5.8e-38 131.0 0.4 1.3 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 CCL99820.1 - 0.0037 17.7 0.1 0.012 16.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3471) Abhydrolase_1 PF00561.20 CCL99821.1 - 3.9e-14 52.9 0.0 7.9e-14 51.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCL99821.1 - 9.3e-12 46.0 0.1 1.1e-11 45.8 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCL99821.1 - 1.4e-08 34.3 0.0 1.3e-07 31.2 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 CCL99821.1 - 0.1 11.6 0.0 0.22 10.5 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Thioesterase PF00975.20 CCL99821.1 - 0.15 12.2 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain HET PF06985.11 CCL99822.1 - 1.6e-24 86.9 0.1 3.6e-24 85.8 0.1 1.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SNF2_N PF00176.23 CCL99823.1 - 8.8e-61 205.5 0.0 2e-60 204.4 0.0 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCL99823.1 - 6.9e-13 48.9 0.0 1.8e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCL99823.1 - 5.4e-08 33.0 0.0 9.8e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.6 CCL99823.1 - 0.00015 21.7 0.9 0.00015 21.7 0.9 2.0 2 0 0 2 2 2 1 RING-type zinc-finger SWI2_SNF2 PF18766.1 CCL99823.1 - 0.00024 20.9 0.0 0.00044 20.0 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase zf-C3HC4 PF00097.25 CCL99823.1 - 0.00025 20.9 0.8 0.00025 20.9 0.8 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCL99823.1 - 0.0032 17.6 1.5 0.0032 17.6 1.5 1.9 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 CCL99823.1 - 0.0048 16.7 1.0 0.0048 16.7 1.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCL99823.1 - 0.013 15.4 2.1 0.013 15.4 2.1 2.6 2 1 0 2 2 2 0 zinc-RING finger domain DUF3638 PF12340.8 CCL99823.1 - 0.013 14.8 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) FYVE PF01363.21 CCL99823.1 - 0.14 12.3 0.3 0.37 10.9 0.3 1.7 1 0 0 1 1 1 0 FYVE zinc finger zf-ribbon_3 PF13248.6 CCL99823.1 - 1.7 8.2 3.8 4 7.0 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_2 PF13639.6 CCL99823.1 - 7.6 7.0 14.1 0.29 11.5 6.7 2.5 2 1 0 2 2 2 0 Ring finger domain Ecl1 PF12855.7 CCL99824.1 - 6.3 7.9 20.2 7.9 7.6 20.2 1.0 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins GramPos_pilinBB PF16569.5 CCL99825.1 - 0.0058 17.4 0.6 0.0092 16.8 0.6 1.3 1 0 0 1 1 1 1 Gram-positive pilin backbone subunit 2, Cna-B-like domain SnoaL_2 PF12680.7 CCL99825.1 - 0.18 12.4 1.9 0.29 11.8 1.9 1.4 1 1 0 1 1 1 0 SnoaL-like domain p450 PF00067.22 CCL99826.1 - 3.4e-74 250.3 0.0 3.8e-74 250.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TAXi_C PF14541.6 CCL99826.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal SSF PF00474.17 CCL99827.1 - 5.5e-22 78.2 26.9 9.4e-22 77.4 26.9 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family Barwin PF00967.17 CCL99828.1 - 0.0031 17.4 0.0 0.0048 16.7 0.0 1.3 1 0 0 1 1 1 1 Barwin family DPBB_1 PF03330.18 CCL99828.1 - 0.0091 16.3 0.2 0.021 15.1 0.2 1.8 1 1 0 1 1 1 1 Lytic transglycolase Fungus-induced PF10917.8 CCL99828.1 - 0.033 14.5 0.1 0.44 10.9 0.0 2.3 2 0 0 2 2 2 0 Fungus-induced protein PseudoU_synth_2 PF00849.22 CCL99829.1 - 4.1e-20 72.5 0.0 6.4e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Gln-synt_N_2 PF16952.5 CCL99832.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Glutamine synthetase N-terminal domain DUF3285 PF11688.8 CCL99833.1 - 0.94 9.4 2.6 16 5.5 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3285) P16-Arc PF04699.14 CCL99834.1 - 1.2e-43 149.2 0.0 1.7e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) F-box PF00646.33 CCL99834.1 - 3.6e-06 26.7 0.1 7.1e-06 25.8 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCL99834.1 - 0.0024 17.7 0.1 0.0063 16.4 0.1 1.8 1 0 0 1 1 1 1 F-box-like Utp12 PF04003.12 CCL99834.1 - 0.096 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Dip2/Utp12 Family WD40 PF00400.32 CCL99835.1 - 5.6e-05 23.8 5.0 0.075 13.9 0.1 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat UIM PF02809.20 CCL99835.1 - 0.0023 17.7 5.2 0.003 17.4 1.0 2.6 2 0 0 2 2 2 1 Ubiquitin interaction motif HNH_2 PF13391.6 CCL99836.1 - 0.0016 18.5 0.2 0.0032 17.6 0.2 1.6 1 1 0 1 1 1 1 HNH endonuclease LIF_OSM PF01291.17 CCL99837.1 - 0.093 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 LIF / OSM family HEPN_AbiU2 PF18734.1 CCL99838.1 - 0.019 14.5 7.5 0.027 14.0 7.5 1.2 1 0 0 1 1 1 0 AbiU2 RNA_pol_Rpc4 PF05132.14 CCL99838.1 - 0.046 14.2 8.2 0.05 14.0 8.2 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 GAGA_bind PF06217.12 CCL99838.1 - 0.34 11.1 9.6 0.43 10.8 9.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family PTPRCAP PF15713.5 CCL99838.1 - 0.4 11.0 11.0 0.51 10.6 11.0 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 CCL99838.1 - 0.53 10.1 16.9 0.64 9.8 16.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CCL99838.1 - 0.74 8.7 7.5 0.89 8.5 7.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Rtf2 PF04641.12 CCL99838.1 - 0.78 9.0 19.4 1 8.7 19.4 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger CPSF100_C PF13299.6 CCL99838.1 - 1.9 8.6 10.5 2.6 8.2 10.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2151 PF10221.9 CCL99838.1 - 3.6 6.1 13.0 4 5.9 13.0 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator MAP17 PF15807.5 CCL99838.1 - 7.3 6.8 11.4 10 6.4 11.4 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TP53IP5 PF15331.6 CCL99838.1 - 7.5 6.6 15.0 10 6.2 15.0 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Ureide_permease PF07168.11 CCL99838.1 - 7.9 5.1 6.8 11 4.7 6.8 1.2 1 0 0 1 1 1 0 Ureide permease Connexin PF00029.19 CCL99838.1 - 8.2 6.1 10.0 10 5.8 10.0 1.2 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 CCL99838.1 - 8.6 4.1 8.1 9.2 4.0 8.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 CCL99838.1 - 9.1 4.9 11.1 11 4.7 11.1 1.1 1 0 0 1 1 1 0 Presenilin FAD_binding_3 PF01494.19 CCL99839.1 - 3.5e-27 95.6 0.0 5.7e-27 94.9 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCL99839.1 - 0.00089 18.6 0.0 0.81 8.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCL99839.1 - 0.01 16.4 0.1 1.4 9.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCL99839.1 - 0.01 15.4 0.7 3.1 7.3 0.0 2.4 2 1 0 2 2 2 0 FAD dependent oxidoreductase SE PF08491.10 CCL99839.1 - 0.18 10.8 0.0 1.9 7.5 0.0 2.0 2 0 0 2 2 2 0 Squalene epoxidase Med1 PF10744.9 CCL99840.1 - 0.014 14.5 0.1 0.61 9.1 0.0 2.4 2 1 0 2 2 2 0 Mediator of RNA polymerase II transcription subunit 1 CAF1A PF12253.8 CCL99840.1 - 0.032 14.4 2.3 0.08 13.1 2.3 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Pkinase PF00069.25 CCL99842.1 - 3e-63 213.7 0.0 3.8e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99842.1 - 2.1e-30 105.9 0.0 2.8e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCL99842.1 - 4.3e-07 29.5 0.0 7.6e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 CCL99842.1 - 0.00085 19.0 0.0 0.13 11.9 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 CCL99842.1 - 0.043 12.8 0.0 0.069 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CCL99842.1 - 0.06 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCL99842.1 - 0.11 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ALS_ss_C PF10369.9 CCL99843.1 - 2.1e-17 63.1 0.1 7.5e-16 58.1 0.0 2.4 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 CCL99843.1 - 7.5e-13 48.0 0.1 1.4e-12 47.2 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 CCL99843.1 - 9.3e-07 28.6 0.1 1.8e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 ACT domain DUF2187 PF09953.9 CCL99843.1 - 0.12 12.3 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) eIF3_p135 PF12807.7 CCL99843.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 COG5 PF10392.9 CCL99844.1 - 8.7e-30 103.6 0.5 2.3e-28 99.0 0.3 2.8 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Vps51 PF08700.11 CCL99844.1 - 1.2e-05 25.3 0.0 8.5e-05 22.6 0.0 2.5 1 1 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 CCL99844.1 - 0.08 13.0 2.6 0.52 10.4 0.9 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.12 CCL99844.1 - 0.094 12.7 2.0 0.77 9.8 0.9 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec5 PF15469.6 CCL99844.1 - 0.097 12.5 2.4 0.36 10.6 2.4 1.9 2 0 0 2 2 2 0 Exocyst complex component Sec5 FlaC_arch PF05377.11 CCL99844.1 - 0.19 12.2 0.5 9.6 6.7 0.1 3.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3759 PF12585.8 CCL99845.1 - 0.16 12.0 0.0 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3759) TPT PF03151.16 CCL99847.1 - 3.6e-26 92.2 13.3 4.6e-26 91.8 13.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCL99847.1 - 8.8e-09 35.6 31.3 1.9e-05 24.9 13.5 2.4 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CCL99847.1 - 4.7e-05 22.8 13.6 0.00018 20.9 13.6 1.9 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 CCL99847.1 - 0.00041 19.7 14.5 0.00088 18.6 14.1 1.8 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport Med31 PF05669.12 CCL99848.1 - 1.6e-35 121.0 7.0 2e-35 120.7 7.0 1.1 1 0 0 1 1 1 1 SOH1 Nod_GRP PF07806.11 CCL99848.1 - 0.016 15.1 2.2 0.47 10.3 0.0 2.3 2 0 0 2 2 2 0 Nodule-specific GRP repeat Peptidase_C12 PF01088.21 CCL99849.1 - 3.4e-54 183.8 0.0 5.6e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 CCL99849.1 - 8.9e-17 60.7 0.4 2e-16 59.6 0.4 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases AA_permease PF00324.21 CCL99850.1 - 7.4e-97 324.9 43.1 2.1e-95 320.1 43.1 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCL99850.1 - 2.2e-23 82.8 45.8 1.5e-20 73.4 46.5 2.5 2 1 0 2 2 2 1 Amino acid permease NTP_transferase PF00483.23 CCL99851.1 - 1.4e-41 142.7 0.0 3.8e-41 141.3 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CCL99851.1 - 4.1e-06 27.2 0.2 9e-06 26.1 0.2 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain MannoseP_isomer PF01050.18 CCL99851.1 - 0.00015 21.7 0.1 0.00025 20.9 0.1 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase IspD PF01128.19 CCL99851.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CCDC92 PF14916.6 CCL99851.1 - 0.026 14.3 2.0 0.18 11.6 0.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain of unknown function CK2S PF15011.6 CCL99851.1 - 0.089 12.7 0.0 0.26 11.2 0.0 1.7 2 0 0 2 2 2 0 Casein Kinase 2 substrate AAA_18 PF13238.6 CCL99853.1 - 6.6e-08 33.2 0.0 4.5e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 CCL99853.1 - 6.9e-06 25.9 0.3 2.4e-05 24.2 0.3 1.7 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 CCL99853.1 - 0.0006 20.0 0.0 0.0016 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 CCL99853.1 - 0.017 15.0 0.0 4.1 7.2 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_28 PF13521.6 CCL99853.1 - 0.031 14.5 0.0 0.071 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCL99853.1 - 0.037 13.3 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 CCL99853.1 - 0.08 13.4 0.2 2.8 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCL99853.1 - 0.2 12.0 0.0 0.47 10.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain FAD_binding_2 PF00890.24 CCL99854.1 - 4.3e-90 302.8 0.5 6.7e-90 302.1 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 CCL99854.1 - 6e-22 77.6 0.0 1.6e-21 76.2 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 CCL99854.1 - 2.5e-12 47.1 0.5 1.6e-11 44.4 0.5 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCL99854.1 - 3.1e-11 43.1 0.0 1.3e-09 37.7 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCL99854.1 - 4.1e-10 39.7 0.4 5e-09 36.2 0.1 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCL99854.1 - 1.8e-08 34.2 2.3 3.6e-08 33.2 2.3 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCL99854.1 - 1.6e-07 30.9 0.2 2.6e-07 30.2 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 CCL99854.1 - 4.7e-06 25.9 1.3 0.00015 21.0 0.5 2.8 3 0 0 3 3 3 1 Glucose inhibited division protein A HI0933_like PF03486.14 CCL99854.1 - 5.5e-06 25.3 3.9 0.00024 19.9 0.4 3.0 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 CCL99854.1 - 6.4e-05 22.3 1.2 0.027 13.7 0.5 2.4 2 0 0 2 2 2 2 Thi4 family Amino_oxidase PF01593.24 CCL99854.1 - 8.1e-05 22.1 0.3 0.032 13.5 0.1 3.1 2 1 1 3 3 3 1 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 CCL99854.1 - 0.00013 21.3 1.8 0.00016 21.0 0.5 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCL99854.1 - 0.00029 20.2 0.1 0.088 12.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCL99854.1 - 0.0006 19.8 0.3 0.018 15.1 0.3 2.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CCL99854.1 - 0.0051 15.9 0.1 0.023 13.7 0.2 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 CCL99854.1 - 0.021 15.4 0.3 0.067 13.8 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCL99854.1 - 0.051 14.0 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding MCRA PF06100.11 CCL99854.1 - 0.17 10.6 0.1 0.3 9.8 0.1 1.4 2 0 0 2 2 2 0 MCRA family 3HCDH_N PF02737.18 CCL99854.1 - 0.18 11.7 0.3 0.34 10.8 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-B_box PF00643.24 CCL99858.1 - 0.19 11.9 1.5 0.32 11.2 1.5 1.4 1 0 0 1 1 1 0 B-box zinc finger HAD_2 PF13419.6 CCL99859.1 - 9.9e-12 45.3 0.0 2.7e-11 43.9 0.0 1.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCL99859.1 - 3.7e-10 40.4 0.0 6.5e-10 39.7 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCL99859.1 - 2.8e-08 33.7 0.1 8e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like RRM_2 PF04059.12 CCL99860.1 - 1.8e-20 73.0 0.1 3.8e-20 71.9 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 CCL99860.1 - 1.1e-12 47.6 0.0 4.5e-05 23.2 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NAD_binding_4 PF07993.12 CCL99861.1 - 6e-27 94.4 0.0 1e-25 90.4 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCL99861.1 - 0.00064 19.3 0.0 0.0013 18.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCL99861.1 - 0.089 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CCL99861.1 - 0.16 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ribosomal_S6 PF01250.17 CCL99862.1 - 1.8e-20 73.0 0.0 2.2e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 SNase PF00565.17 CCL99863.1 - 1.3e-54 183.2 0.6 4.4e-18 65.7 0.0 6.1 5 1 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 CCL99863.1 - 9e-20 70.9 0.0 1.9e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 CCL99863.1 - 0.065 13.7 0.2 0.35 11.4 0.0 2.5 3 0 0 3 3 3 0 Agenet domain PIF1 PF05970.14 CCL99864.1 - 2.2e-71 241.0 0.0 2.9e-71 240.6 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase Aldo_ket_red PF00248.21 CCL99864.1 - 1.6e-45 155.6 0.0 2.4e-43 148.5 0.0 2.4 1 1 0 1 1 1 1 Aldo/keto reductase family AAA_30 PF13604.6 CCL99864.1 - 2.3e-10 40.5 0.0 5.4e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCL99864.1 - 0.00054 20.4 0.0 0.0065 16.9 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain DUF2075 PF09848.9 CCL99864.1 - 0.0024 17.2 0.0 0.17 11.1 0.0 2.4 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 CCL99864.1 - 0.0041 17.5 0.0 0.018 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF2791 PF10923.8 CCL99864.1 - 0.027 13.3 0.0 0.043 12.7 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Peptidase_M19 PF01244.21 CCL99865.1 - 2.7e-101 338.9 0.0 3.3e-101 338.6 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) DUF647 PF04884.14 CCL99865.1 - 0.035 13.7 0.1 0.059 13.0 0.1 1.3 1 0 0 1 1 1 0 Vitamin B6 photo-protection and homoeostasis FA_desaturase PF00487.24 CCL99866.1 - 3.4e-21 76.2 24.4 3.9e-19 69.5 24.4 2.2 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CCL99866.1 - 3.5e-05 24.0 0.1 7.3e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Amidohydro_2 PF04909.14 CCL99867.1 - 0.075 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Amidohydrolase Yae1_N PF09811.9 CCL99868.1 - 3.6e-08 33.0 25.2 3.9e-05 23.3 7.7 3.7 2 1 1 3 3 3 2 Essential protein Yae1, N terminal Trypan_PARP PF05887.11 CCL99868.1 - 0.01 15.8 9.3 0.027 14.4 9.3 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF5636 PF18686.1 CCL99868.1 - 0.13 12.4 1.8 2.2 8.4 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5636) SPAN-X PF07458.12 CCL99868.1 - 0.23 11.9 4.8 0.38 11.2 3.0 2.2 1 1 1 2 2 2 0 Sperm protein associated with nucleus, mapped to X chromosome SpecificRecomb PF10136.9 CCL99868.1 - 6.5 4.9 9.0 9.1 4.4 9.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase MIF4G PF02854.19 CCL99869.1 - 4.5e-42 144.1 0.0 3.4e-28 98.7 0.0 4.1 3 0 0 3 3 3 2 MIF4G domain Upf2 PF04050.14 CCL99869.1 - 7.4e-31 107.7 1.7 7.4e-31 107.7 1.7 3.8 3 0 0 3 3 3 1 Up-frameshift suppressor 2 AATF-Che1 PF13339.6 CCL99869.1 - 0.017 15.8 1.3 0.017 15.8 1.3 3.9 4 0 0 4 4 4 0 Apoptosis antagonizing transcription factor Macoilin PF09726.9 CCL99869.1 - 0.3 9.6 12.7 0.014 14.0 5.8 2.1 2 0 0 2 2 2 0 Macoilin family DUF3810 PF12725.7 CCL99869.1 - 1.9 7.7 5.1 6.7 6.0 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Inhibitor_I66 PF16850.5 CCL99870.1 - 8.5e-34 116.5 0.0 9.5e-34 116.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase inhibitor I66 adh_short PF00106.25 CCL99871.1 - 5.4e-38 130.4 0.7 7.6e-38 129.9 0.7 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCL99871.1 - 3.3e-21 75.9 0.1 4.6e-21 75.5 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 CCL99871.1 - 0.0018 17.7 0.0 0.0067 15.8 0.0 1.7 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 CCL99871.1 - 0.0022 18.0 0.2 0.0074 16.2 0.2 2.1 1 1 0 1 1 1 1 KR domain NAD_binding_2 PF03446.15 CCL99871.1 - 0.1 12.7 0.0 0.3 11.2 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase COX7C PF02935.16 CCL99871.1 - 0.14 12.5 1.2 0.52 10.6 0.0 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc Mito_carr PF00153.27 CCL99872.1 - 2.4e-32 110.7 0.6 1.3e-11 44.3 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein TFIIA_gamma_N PF02268.16 CCL99874.1 - 0.079 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain ubiquitin PF00240.23 CCL99875.1 - 5.3e-137 445.8 18.7 1.3e-33 114.5 0.5 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 CCL99875.1 - 3.3e-63 209.5 20.7 3.1e-15 55.8 0.6 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCL99875.1 - 3.6e-23 81.8 9.6 0.00034 21.0 0.1 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 CCL99875.1 - 6.8e-16 58.0 3.6 0.034 14.1 0.1 4.3 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCL99875.1 - 1.8e-14 53.8 2.9 0.11 12.6 0.0 5.0 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CCL99875.1 - 3.6e-14 52.9 8.7 0.044 14.1 0.2 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain DUF2407 PF10302.9 CCL99875.1 - 6.1e-13 49.2 1.3 0.37 11.4 0.0 4.2 1 1 3 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 CCL99875.1 - 7.7e-10 38.8 0.4 1.2 9.0 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 CCL99875.1 - 5.4e-07 29.2 0.6 1 8.6 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase Ubiquitin_4 PF18036.1 CCL99875.1 - 5.4e-07 29.6 24.6 16 5.6 0.2 8.0 8 0 0 8 8 8 0 Ubiquitin-like domain Big_7 PF17957.1 CCL99875.1 - 4.6e-06 27.3 0.2 27 5.6 0.0 4.2 4 0 0 4 4 4 0 Bacterial Ig domain DUF3861 PF12977.7 CCL99875.1 - 5.7e-06 26.4 3.3 13 6.1 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 CCL99875.1 - 6.5e-06 26.4 0.0 31 5.1 0.0 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) ACT_5 PF13710.6 CCL99875.1 - 9.7e-06 25.3 4.4 8.3 6.3 0.1 4.3 4 0 0 4 4 4 0 ACT domain TmoB PF06234.12 CCL99875.1 - 1.2e-05 25.3 0.1 30 4.8 0.0 4.8 4 0 0 4 4 4 0 Toluene-4-monooxygenase system protein B (TmoB) UDP-g_GGTase PF06427.11 CCL99875.1 - 2.8e-05 24.2 3.6 7.2 6.8 0.0 4.2 4 0 0 4 4 4 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 CCL99875.1 - 0.0004 19.9 0.1 22 4.4 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) ACT_4 PF13291.6 CCL99875.1 - 0.00047 20.7 2.4 29 5.4 0.1 4.3 4 0 0 4 4 4 0 ACT domain DUF493 PF04359.14 CCL99875.1 - 0.0032 18.0 0.1 1.4e+02 3.2 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF493) ORF11CD3 PF10549.9 CCL99875.1 - 0.0077 16.3 0.0 94 3.2 0.0 4.2 4 0 0 4 4 4 0 ORF11CD3 domain ProRS-C_2 PF09181.10 CCL99875.1 - 0.012 15.7 5.2 66 3.7 0.1 4.1 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal FlgD_ig PF13860.6 CCL99875.1 - 0.039 13.8 9.0 42 4.1 0.1 4.4 4 0 0 4 4 4 0 FlgD Ig-like domain Tash_PEST PF07708.11 CCL99875.1 - 0.15 12.3 27.2 6.4 7.1 1.4 4.4 4 0 0 4 4 4 0 Tash protein PEST motif ACP PF06857.11 CCL99875.1 - 0.21 11.8 8.9 1.8 8.8 0.5 4.4 4 0 0 4 4 4 0 Malonate decarboxylase delta subunit (MdcD) Phage_sheath_1N PF17481.2 CCL99875.1 - 0.36 11.3 9.7 47 4.5 1.2 4.0 1 1 1 2 2 2 0 Phage tail sheath protein beta-sandwich domain YcgR_2 PF12945.7 CCL99875.1 - 1.2 9.4 4.6 2.4e+02 1.9 0.0 4.0 4 0 0 4 4 4 0 Flagellar protein YcgR PI3K_p85B PF02192.16 CCL99875.1 - 1.3 8.8 8.5 99 2.8 0.1 4.2 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain Cnl2_NKP2 PF09447.10 CCL99875.1 - 1.4 9.2 9.9 1e+02 3.1 0.1 4.4 4 0 0 4 4 4 0 Cnl2/NKP2 family protein CHAT PF12770.7 CCL99877.1 - 1.6e-33 116.4 0.0 2.7e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 CHAT domain LRR_2 PF07723.13 CCL99878.1 - 0.024 15.3 0.3 0.12 13.1 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat F-box-like PF12937.7 CCL99878.1 - 0.077 12.9 0.3 0.21 11.5 0.3 1.8 1 0 0 1 1 1 0 F-box-like DUF4162 PF13732.6 CCL99881.1 - 0.041 14.6 0.1 1.8e+02 3.0 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4162) FliN_N PF16973.5 CCL99881.1 - 0.11 12.3 2.4 52 3.8 0.0 3.8 1 1 3 4 4 4 0 Flagellar motor switch protein FliN N-terminal S_100 PF01023.19 CCL99881.1 - 0.24 11.1 0.1 65 3.3 0.0 3.1 3 0 0 3 3 3 0 S-100/ICaBP type calcium binding domain IBV_3B PF03622.13 CCL99881.1 - 3.5 7.8 4.4 1.7e+02 2.4 0.0 3.7 4 0 0 4 4 4 0 IBV 3B protein LANC_like PF05147.13 CCL99882.1 - 6.7e-07 28.2 0.0 1.2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein TEX19 PF15553.6 CCL99882.1 - 0.048 13.6 0.3 0.1 12.6 0.3 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 Glyoxal_oxid_N PF07250.11 CCL99883.1 - 2.8e-28 98.7 0.2 2.5e-12 46.5 0.0 4.7 4 1 1 5 5 5 3 Glyoxal oxidase N-terminus DUF1929 PF09118.11 CCL99883.1 - 9.6e-21 73.9 0.2 2.2e-20 72.7 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_4 PF13418.6 CCL99883.1 - 0.071 13.1 2.1 3.2 7.8 0.1 4.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Pkinase PF00069.25 CCL99884.1 - 5.3e-27 94.8 0.0 4.6e-26 91.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99884.1 - 2.9e-12 46.4 0.0 5.5e-06 25.9 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase RIO1 PF01163.22 CCL99884.1 - 0.044 13.4 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family ATG13 PF10033.9 CCL99885.1 - 1.9e-45 155.4 0.0 2.7e-45 155.0 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 13 Oxidored_FMN PF00724.20 CCL99889.1 - 7.9e-103 344.3 0.0 9e-103 344.1 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.20 CCL99890.1 - 1.7e-103 346.5 0.0 1.9e-103 346.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Oxidored_FMN PF00724.20 CCL99891.1 - 5.6e-99 331.6 0.0 6.4e-99 331.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family CPL PF08144.11 CCL99892.1 - 4.1e-34 118.0 0.0 1.4e-30 106.5 0.0 3.7 3 0 0 3 3 3 2 CPL (NUC119) domain 5-FTHF_cyc-lig PF01812.20 CCL99892.1 - 0.081 12.8 1.4 1 9.1 0.0 2.8 3 1 1 4 4 4 0 5-formyltetrahydrofolate cyclo-ligase family BING4CT PF08149.11 CCL99893.1 - 1.1e-37 127.7 0.0 3e-36 123.1 0.0 2.8 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.32 CCL99893.1 - 0.00048 20.9 0.1 0.00048 20.9 0.1 3.6 5 0 0 5 5 5 1 WD domain, G-beta repeat YL1_C PF08265.11 CCL99894.1 - 4.5e-14 51.9 0.2 4.5e-14 51.9 0.2 1.5 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain CDC27 PF09507.10 CCL99894.1 - 0.15 11.4 1.9 0.18 11.2 1.9 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Dna2 PF08696.11 CCL99895.1 - 5e-55 186.5 0.0 9.2e-55 185.6 0.0 1.4 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 CCL99895.1 - 3.2e-50 170.6 0.1 4.6e-50 170.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCL99895.1 - 1.2e-32 113.8 0.1 4e-17 62.9 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 CCL99895.1 - 9e-15 54.9 0.0 2e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCL99895.1 - 1.1e-10 42.1 0.0 2.8e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCL99895.1 - 3.6e-05 23.6 0.4 0.36 10.5 0.0 3.2 2 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 CCL99895.1 - 0.00025 20.9 0.0 0.00051 19.9 0.0 1.5 1 0 0 1 1 1 1 Helicase AAA PF00004.29 CCL99895.1 - 0.00048 20.6 0.2 0.0078 16.6 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Cas_Cas4 PF01930.17 CCL99895.1 - 0.0012 18.9 0.0 0.0056 16.8 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function DUF83 UvrD-helicase PF00580.21 CCL99895.1 - 0.0036 16.9 0.5 0.016 14.8 0.1 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.22 CCL99895.1 - 0.0078 15.9 0.3 0.029 14.0 0.1 2.0 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 CCL99895.1 - 0.0087 16.5 0.1 0.057 13.8 0.1 2.5 2 1 0 2 2 1 1 AAA ATPase domain ResIII PF04851.15 CCL99895.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PIF1 PF05970.14 CCL99895.1 - 0.013 14.7 0.1 1.2 8.2 0.1 2.4 2 0 0 2 2 2 0 PIF1-like helicase DUF87 PF01935.17 CCL99895.1 - 0.022 14.9 0.5 0.05 13.7 0.5 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain MeaB PF03308.16 CCL99895.1 - 0.024 13.6 0.3 0.12 11.4 0.1 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 CCL99895.1 - 0.034 13.4 0.0 0.08 12.2 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 CCL99895.1 - 0.038 13.7 0.0 0.084 12.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CCL99895.1 - 0.07 13.0 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 CCL99895.1 - 0.11 13.0 0.0 0.34 11.4 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CCL99895.1 - 0.12 11.9 0.1 0.23 11.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ECH_1 PF00378.20 CCL99896.1 - 2.3e-55 187.6 0.0 2.7e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCL99896.1 - 5e-31 108.4 0.0 4.5e-29 102.0 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Totivirus_coat PF05518.11 CCL99897.1 - 9.6 4.1 7.1 16 3.4 7.1 1.2 1 0 0 1 1 1 0 Totivirus coat protein MFS_1 PF07690.16 CCL99898.1 - 4.9e-20 71.8 28.3 3e-19 69.2 28.7 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCL99899.1 - 3.7e-19 68.8 32.1 1.3e-18 67.1 32.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCL99900.1 - 2.5e-23 82.6 30.0 2.5e-23 82.6 30.0 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily AAA PF00004.29 CCL99901.1 - 2e-12 47.7 0.0 4e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCL99901.1 - 0.00067 20.0 0.5 0.15 12.3 0.0 3.5 1 1 2 3 3 3 1 AAA domain AAA_5 PF07728.14 CCL99901.1 - 0.00081 19.4 0.0 0.0021 18.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CCL99901.1 - 0.0086 15.8 0.1 0.017 14.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCL99901.1 - 0.03 14.7 0.2 0.15 12.4 0.2 2.3 1 1 0 1 1 1 0 AAA ATPase domain MeaB PF03308.16 CCL99901.1 - 0.047 12.7 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Xan_ur_permease PF00860.20 CCL99902.1 - 1.9e-55 188.1 32.5 1.9e-55 188.1 32.5 2.5 2 1 0 2 2 2 1 Permease family DUF4177 PF13783.6 CCL99903.1 - 0.037 14.3 0.0 0.093 13.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4177) DUF4712 PF15830.5 CCL99904.1 - 0.11 12.1 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4712) GST_N PF02798.20 CCL99910.1 - 2.6e-18 66.2 0.0 1.5e-17 63.7 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCL99910.1 - 2.9e-15 56.3 0.0 6.6e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCL99910.1 - 2e-12 47.3 0.0 4.1e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCL99910.1 - 2.8e-12 46.8 0.0 8.4e-12 45.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCL99910.1 - 9.7e-10 38.5 0.0 2.6e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCL99910.1 - 5.7e-07 29.5 0.0 2.9e-06 27.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain TMEM135_C_rich PF15982.5 CCL99910.1 - 5.6e-05 23.7 3.7 0.00033 21.3 1.5 2.9 2 1 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 Tim17 PF02466.19 CCL99910.1 - 0.005 17.2 1.9 3.7 8.0 0.1 3.9 4 0 0 4 4 4 1 Tim17/Tim22/Tim23/Pmp24 family GST_N PF02798.20 CCL99911.1 - 2.6e-14 53.3 0.1 7.8e-14 51.8 0.0 1.9 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCL99911.1 - 6.2e-12 45.8 0.0 9.4e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCL99911.1 - 2.1e-11 43.9 0.0 3.7e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCL99911.1 - 4.5e-11 42.9 0.1 1.4e-10 41.3 0.0 1.8 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCL99911.1 - 3e-05 24.1 0.0 5.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCL99911.1 - 6.2e-05 22.9 0.0 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCL99911.1 - 0.014 16.0 0.1 0.56 10.8 0.0 2.2 1 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF3791 PF12668.7 CCL99911.1 - 0.02 14.9 0.1 0.29 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) Y_phosphatase PF00102.27 CCL99913.1 - 9.2e-38 130.1 0.0 4.1e-32 111.6 0.0 2.5 2 1 0 2 2 2 2 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CCL99913.1 - 2.6e-07 30.9 0.0 0.00065 19.8 0.0 2.5 2 0 0 2 2 2 2 Inositol hexakisphosphate DSPc PF00782.20 CCL99913.1 - 0.00078 19.3 0.0 0.0062 16.3 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CCL99913.1 - 0.00097 19.2 0.1 0.0018 18.3 0.1 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF3093 PF11292.8 CCL99913.1 - 0.05 13.9 0.1 0.15 12.3 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) His_Phos_2 PF00328.22 CCL99914.1 - 7.7e-25 88.0 0.0 1e-24 87.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) NTP_transf_3 PF12804.7 CCL99914.1 - 0.12 12.7 0.1 0.21 11.9 0.1 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain Mo25 PF08569.11 CCL99916.1 - 2.6e-134 447.7 3.3 3e-134 447.5 3.3 1.0 1 0 0 1 1 1 1 Mo25-like adh_short_C2 PF13561.6 CCL99917.1 - 3.5e-50 170.7 0.0 4.4e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCL99917.1 - 7e-36 123.5 0.0 4.3e-35 120.9 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCL99917.1 - 1.7e-10 41.1 0.0 2.6e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Uricase PF01014.18 CCL99918.1 - 7.4e-64 213.9 0.6 1.6e-33 115.8 0.3 2.4 2 0 0 2 2 2 2 Uricase ATP-synt_G PF04718.15 CCL99919.1 - 0.00076 20.3 0.2 0.0028 18.4 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit PH PF00169.29 CCL99919.1 - 0.16 12.5 0.0 0.29 11.7 0.0 1.4 1 0 0 1 1 1 0 PH domain SNARE_assoc PF09335.11 CCL99920.1 - 4.6e-16 59.4 7.9 4.6e-16 59.4 7.9 2.9 2 1 1 3 3 3 1 SNARE associated Golgi protein Abhydrolase_6 PF12697.7 CCL99921.1 - 1.3e-12 48.8 0.8 1.3e-11 45.6 0.2 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCL99921.1 - 1.9e-08 34.3 0.0 5.3e-08 32.8 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCL99921.1 - 8.2e-05 22.0 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 F-box-like PF12937.7 CCL99921.1 - 0.00044 20.1 0.2 0.0012 18.7 0.2 1.8 1 0 0 1 1 1 1 F-box-like Thioesterase PF00975.20 CCL99921.1 - 0.0049 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 CCL99921.1 - 0.0062 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold zf-CCCH PF00642.24 CCL99923.1 - 2.6e-14 52.7 15.6 1.7e-06 27.7 0.4 4.1 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCL99923.1 - 2.9e-10 40.8 14.9 0.00061 20.5 0.2 4.1 3 1 1 4 4 4 3 Torus domain zf_CCCH_4 PF18345.1 CCL99923.1 - 2.8e-09 36.7 24.5 7.7e-06 25.8 2.8 5.3 5 1 0 5 5 5 2 Zinc finger domain zf-CCCH_2 PF14608.6 CCL99923.1 - 1.7e-06 28.3 31.5 0.021 15.3 3.8 4.5 4 0 0 4 4 4 3 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CCL99923.1 - 2.6e-05 23.9 10.9 0.00022 21.0 1.6 4.2 5 0 0 5 5 5 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CCL99923.1 - 2.8 8.2 6.6 9.1 6.5 0.9 3.1 3 1 0 3 3 3 0 Zinc-finger containing family FliJ PF02050.16 CCL99924.1 - 0.0025 18.0 1.4 0.0025 18.0 1.4 2.8 3 0 0 3 3 3 1 Flagellar FliJ protein DNA_pol3_tau_4 PF12168.8 CCL99924.1 - 1.5 9.4 7.1 0.13 12.8 1.1 2.2 2 0 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding FTCD_C PF04961.12 CCL99924.1 - 7.1 6.4 7.0 0.64 9.8 1.1 2.2 3 0 0 3 3 3 0 Formiminotransferase-cyclodeaminase zf-C3HC4 PF00097.25 CCL99925.1 - 2.1e-06 27.5 5.2 4.6e-06 26.4 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCL99925.1 - 6.4e-06 25.9 4.3 1.1e-05 25.2 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCL99925.1 - 0.00015 21.7 6.6 0.00015 21.7 6.6 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCL99925.1 - 0.0005 20.0 6.7 0.001 19.0 6.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCL99925.1 - 0.00059 20.1 5.2 0.0013 19.0 5.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCL99925.1 - 0.011 15.6 6.4 0.011 15.6 6.4 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCL99925.1 - 0.046 13.6 9.8 0.096 12.6 8.8 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 COPIIcoated_ERV PF07970.12 CCL99926.1 - 2.5e-35 122.4 1.2 3.7e-35 121.8 1.2 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CCL99926.1 - 2.4e-21 75.9 0.0 4.1e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Hus1 PF04005.12 CCL99927.1 - 3.1e-69 233.3 0.0 3.4e-69 233.2 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein Isochorismatase PF00857.20 CCL99928.1 - 8.1e-15 55.4 0.0 1.1e-14 55.0 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family DUF2336 PF10098.9 CCL99929.1 - 0.16 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2336) Maf PF02545.14 CCL99930.1 - 1.8e-44 151.5 0.0 2e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein SKIP_SNW PF02731.15 CCL99931.1 - 0.054 13.2 0.2 0.062 13.0 0.2 1.1 1 0 0 1 1 1 0 SKIP/SNW domain Glutaredoxin PF00462.24 CCL99932.1 - 4.4e-18 65.3 0.0 3.4e-16 59.2 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 CCL99932.1 - 5.1e-16 58.5 0.0 1.4e-15 57.1 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin HyaE PF07449.11 CCL99932.1 - 2e-05 24.5 0.0 0.00017 21.5 0.0 2.2 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_8 PF13905.6 CCL99932.1 - 0.00022 21.5 0.0 0.05 13.9 0.0 2.5 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 CCL99932.1 - 0.0047 17.4 0.0 0.062 13.8 0.0 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain Phosducin PF02114.16 CCL99932.1 - 0.011 14.7 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosducin Thioredoxin_3 PF13192.6 CCL99932.1 - 0.053 13.6 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin domain GST_N_3 PF13417.6 CCL99932.1 - 0.055 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Ku PF02735.16 CCL99933.1 - 1e-32 113.6 0.0 1.8e-32 112.7 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 CCL99933.1 - 1.7e-18 67.2 0.0 2.8e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain SAP PF02037.27 CCL99933.1 - 0.00012 21.7 0.1 0.0006 19.5 0.0 2.2 2 0 0 2 2 2 1 SAP domain Ku_C PF03730.14 CCL99933.1 - 0.031 15.0 0.4 0.25 12.1 0.1 2.7 2 1 0 2 2 2 0 Ku70/Ku80 C-terminal arm PTPA PF03095.15 CCL99934.1 - 3.6e-96 322.2 0.0 4.8e-96 321.8 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Orn_Arg_deC_N PF02784.16 CCL99934.1 - 2.1e-76 256.5 0.0 2.8e-76 256.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CCL99934.1 - 9.3e-15 54.7 0.0 1.9e-14 53.7 0.0 1.6 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 CCL99934.1 - 0.09 12.2 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel HSP70 PF00012.20 CCL99935.1 - 0.0012 17.2 0.2 0.0012 17.2 0.2 2.0 2 0 0 2 2 2 1 Hsp70 protein PilM_2 PF11104.8 CCL99935.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; Zn_clus PF00172.18 CCL99936.1 - 2.3e-08 34.0 9.7 3.3e-08 33.5 9.7 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_61 PF03443.14 CCL99937.1 - 1.8e-52 178.3 0.0 2.1e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Big_8 PF17961.1 CCL99937.1 - 0.086 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig domain F-box-like PF12937.7 CCL99938.1 - 6.8e-08 32.3 0.2 3.6e-07 30.0 0.1 2.5 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 CCL99938.1 - 0.26 11.8 6.9 14 6.3 0.1 5.2 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCL99938.1 - 2 8.3 6.5 6 6.7 0.3 4.2 4 1 0 4 4 4 0 Leucine rich repeat zf-UBP PF02148.19 CCL99939.1 - 3.7e-26 91.2 14.4 2.5e-21 75.7 2.1 2.7 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 CCL99939.1 - 4.9e-26 91.8 0.0 9.7e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 CCL99939.1 - 8.2e-24 83.1 4.5 2.4e-23 81.6 0.8 2.6 2 0 0 2 2 2 1 Variant UBP zinc finger UBA PF00627.31 CCL99939.1 - 1.9e-11 43.6 0.5 4.5e-11 42.4 0.5 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UCH_1 PF13423.6 CCL99939.1 - 5.8e-08 32.7 0.0 2.6e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Mu-like_Com PF10122.9 CCL99939.1 - 0.0081 15.6 0.3 2.1 7.9 0.0 2.8 2 0 0 2 2 2 2 Mu-like prophage protein Com zf-C2HE PF16278.5 CCL99939.1 - 0.022 15.2 0.7 0.82 10.2 0.1 3.2 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_SprT PF17283.2 CCL99939.1 - 0.042 13.8 6.0 0.94 9.4 0.1 5.0 5 1 0 5 5 5 0 SprT-like zinc ribbon domain UBA PF00627.31 CCL99940.1 - 4.7e-13 48.8 0.0 7.3e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain UCH PF00443.29 CCL99940.1 - 6.8e-13 48.7 0.0 6.8e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCL99940.1 - 4.7e-08 33.0 0.0 4.7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 CCL99940.1 - 0.05 13.4 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 UBA-like domain HOIP-UBA PF16678.5 CCL99940.1 - 0.066 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair NAP PF00956.18 CCL99941.1 - 1.5e-87 293.2 3.1 2.3e-87 292.6 3.1 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) zf-4CXXC_R1 PF10497.9 CCL99942.1 - 1e-09 38.5 14.5 2.7e-09 37.1 14.5 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 CALCOCO1 PF07888.11 CCL99943.1 - 0.17 10.7 13.8 0.039 12.8 9.3 1.8 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.6 CCL99943.1 - 0.25 10.6 7.4 8.1 5.7 0.0 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 CCL99943.1 - 0.34 11.3 8.6 6 7.3 7.4 2.3 2 0 0 2 2 2 0 Fez1 Tup_N PF08581.10 CCL99943.1 - 0.49 10.7 2.5 1.3 9.4 2.5 1.6 1 0 0 1 1 1 0 Tup N-terminal APG6_N PF17675.1 CCL99943.1 - 1.1 9.8 13.2 8.7 6.9 8.7 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region Herpes_UL25 PF01499.16 CCL99943.1 - 1.4 7.4 3.4 2.5 6.5 3.4 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family CENP-F_leu_zip PF10473.9 CCL99943.1 - 1.6 8.7 10.1 0.32 11.0 6.3 1.7 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 CCL99943.1 - 2.8 8.0 11.5 0.47 10.5 4.3 2.6 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Uso1_p115_C PF04871.13 CCL99943.1 - 2.9 8.3 7.6 1.5 9.2 2.5 2.4 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-Q PF13094.6 CCL99943.1 - 4.7 7.4 9.9 4.9 7.3 8.4 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit ZapB PF06005.12 CCL99943.1 - 6.7 7.2 6.6 10 6.6 0.0 2.5 2 0 0 2 2 2 0 Cell division protein ZapB Hydrolase PF00702.26 CCL99944.1 - 4.9e-11 43.3 0.0 5.5e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCL99944.1 - 4.7e-08 33.3 0.0 4.3e-07 30.2 0.0 2.1 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCL99944.1 - 5.2e-05 23.2 0.0 8.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like dCMP_cyt_deam_1 PF00383.23 CCL99945.1 - 6.1e-16 58.1 0.0 3.6e-15 55.7 0.0 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCL99945.1 - 8.8e-13 48.2 0.0 1.6e-12 47.4 0.0 1.4 1 1 0 1 1 1 1 MafB19-like deaminase APOBEC2 PF18772.1 CCL99945.1 - 0.00073 19.6 0.0 0.013 15.6 0.0 2.0 1 1 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 CCL99945.1 - 0.0013 18.9 0.0 0.03 14.4 0.0 2.0 1 1 0 1 1 1 1 Novel AID APOBEC clade 1 SNAD4 PF18750.1 CCL99945.1 - 0.0024 18.0 0.0 0.008 16.3 0.0 1.7 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_N PF08210.11 CCL99945.1 - 0.017 15.0 0.0 0.16 11.8 0.1 2.0 1 1 0 1 1 1 0 APOBEC-like N-terminal domain NAD2 PF18782.1 CCL99945.1 - 0.049 13.7 0.0 0.19 11.8 0.0 1.8 1 1 0 1 1 1 0 Novel AID APOBEC clade 2 Bd3614-deam PF14439.6 CCL99945.1 - 0.05 13.7 0.1 0.089 12.9 0.1 1.5 1 1 0 1 1 1 0 Bd3614-like deaminase FMO-like PF00743.19 CCL99946.1 - 9.4e-21 73.8 0.1 2.2e-16 59.4 0.0 2.6 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCL99946.1 - 6.9e-16 58.4 0.0 1.4e-13 50.8 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCL99946.1 - 3.9e-14 52.6 0.1 3e-10 39.8 0.0 2.9 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCL99946.1 - 1.6e-10 40.6 0.1 3.7e-08 32.9 0.1 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CCL99946.1 - 3.2e-06 27.6 0.1 0.2 12.3 0.0 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCL99946.1 - 5.3e-05 23.4 0.1 0.00022 21.4 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCL99946.1 - 0.00017 21.3 4.7 0.076 12.6 0.2 2.5 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCL99946.1 - 0.00027 21.0 1.5 0.22 11.5 0.1 3.6 4 0 0 4 4 3 1 FAD-NAD(P)-binding SnoaL_2 PF12680.7 CCL99946.1 - 0.0003 21.4 0.6 0.0013 19.4 0.1 2.3 2 0 0 2 2 2 1 SnoaL-like domain FAD_binding_3 PF01494.19 CCL99946.1 - 0.00046 19.5 0.0 0.0015 17.9 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 CCL99946.1 - 0.004 16.3 0.5 0.0098 15.0 0.5 1.6 1 0 0 1 1 1 1 FAD binding domain SnoaL_3 PF13474.6 CCL99946.1 - 0.0052 17.0 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like domain Amino_oxidase PF01593.24 CCL99946.1 - 0.0069 15.7 0.1 5.8 6.1 0.0 3.1 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCL99946.1 - 0.025 14.0 0.5 0.14 11.5 0.2 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 CCL99946.1 - 0.041 13.3 0.0 0.23 10.8 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CCL99946.1 - 0.05 12.6 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 CCL99946.1 - 0.064 11.9 0.1 0.15 10.8 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein p450 PF00067.22 CCL99947.1 - 1.6e-65 221.7 0.0 1.1e-64 219.0 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 HA2 PF04408.23 CCL99949.1 - 9.6e-22 77.3 0.0 9.6e-22 77.3 0.0 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCL99949.1 - 9.8e-15 54.7 0.0 2.5e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCL99949.1 - 3.9e-13 49.7 0.0 9e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCL99949.1 - 3.3e-08 33.5 0.0 6.7e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCL99949.1 - 5e-06 26.8 0.2 1.9e-05 24.9 0.2 1.9 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CCL99949.1 - 0.00018 20.9 0.0 0.00033 20.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CCL99949.1 - 0.00065 19.5 0.0 0.002 17.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCL99949.1 - 0.0055 15.8 0.0 0.012 14.7 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 CCL99949.1 - 0.0075 16.6 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CCL99949.1 - 0.018 14.4 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 KaiC ResIII PF04851.15 CCL99949.1 - 0.021 14.8 0.0 9.1 6.2 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 CCL99949.1 - 0.034 13.8 0.1 0.1 12.2 0.1 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 CCL99949.1 - 0.04 13.9 0.1 0.32 11.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCL99949.1 - 0.074 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CCL99949.1 - 0.086 12.6 0.0 9.4 5.9 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein PhoH PF02562.16 CCL99949.1 - 0.1 12.1 0.0 0.31 10.5 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 CCL99949.1 - 0.11 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCL99949.1 - 0.12 12.9 0.0 0.37 11.3 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 CCL99949.1 - 1.8 9.0 0.0 1.8 9.0 0.0 2.9 3 1 0 3 3 3 0 AAA domain SPRY PF00622.28 CCL99950.1 - 6.9e-21 74.6 0.0 1.1e-20 73.9 0.0 1.4 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 CCL99950.1 - 1.4e-18 67.2 0.0 5e-18 65.4 0.0 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCL99950.1 - 0.019 14.9 0.3 0.051 13.5 0.1 1.8 2 0 0 2 2 2 0 LisH p450 PF00067.22 CCL99951.1 - 1.3e-50 172.5 0.0 1.6e-50 172.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCL99952.1 - 1e-72 245.4 0.0 1.2e-72 245.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 CCL99953.1 - 9.9e-21 74.3 0.0 1.7e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCL99953.1 - 2.1e-07 30.5 0.0 2.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCL99953.1 - 0.0099 15.8 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCL99953.1 - 0.014 15.0 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 CCL99953.1 - 0.021 14.2 0.2 0.032 13.6 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family p450 PF00067.22 CCL99955.1 - 1.4e-75 254.8 0.0 1.7e-75 254.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Reticulon PF02453.17 CCL99955.1 - 0.077 13.0 0.2 0.22 11.5 0.0 1.9 3 0 0 3 3 3 0 Reticulon p450 PF00067.22 CCL99956.1 - 2.1e-29 102.6 0.0 2.4e-29 102.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase_fungal PF17667.1 CCL99957.1 - 1.6e-25 89.7 0.1 2.7e-23 82.4 0.1 2.1 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCL99957.1 - 0.00021 21.3 0.2 0.00039 20.4 0.2 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCL99957.1 - 0.0086 15.4 0.2 0.023 14.1 0.2 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCL99957.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Nfu_N PF08712.11 CCL99958.1 - 6.7e-30 103.0 0.0 1.4e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 CCL99958.1 - 2.5e-26 91.6 0.1 5e-26 90.7 0.1 1.5 1 0 0 1 1 1 1 NifU-like domain EIF_2_alpha PF07541.12 CCL99958.1 - 0.065 13.3 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit DUF4745 PF15923.5 CCL99958.1 - 0.084 12.8 0.1 3.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) ABC_tran PF00005.27 CCL99959.1 - 7.6e-26 91.3 0.0 2e-25 89.9 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCL99959.1 - 1.9e-09 37.8 0.0 0.0002 21.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCL99959.1 - 1e-06 28.3 0.1 0.053 13.0 0.5 2.7 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CCL99959.1 - 3.5e-06 27.0 0.0 6.8e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CCL99959.1 - 0.00028 21.4 0.1 0.0005 20.6 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCL99959.1 - 0.0013 18.4 0.1 0.003 17.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CCL99959.1 - 0.005 16.6 0.0 0.0099 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.6 CCL99959.1 - 0.026 14.1 0.0 0.056 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCL99959.1 - 0.029 14.7 0.0 0.095 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCL99959.1 - 0.032 14.1 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 CCL99959.1 - 0.042 13.1 0.0 0.086 12.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin UQ_con PF00179.26 CCL99961.1 - 3.5e-13 49.4 0.0 4.5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCL99961.1 - 0.017 14.8 0.1 0.098 12.4 0.1 1.8 1 1 1 2 2 2 0 Prokaryotic E2 family B Porphobil_deam PF01379.20 CCL99962.1 - 2.4e-63 213.3 0.0 3.5e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CCL99962.1 - 6.8e-19 68.0 0.1 1.3e-18 67.1 0.1 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain UMP1 PF05348.11 CCL99963.1 - 9e-34 116.2 0.4 1.1e-33 115.9 0.4 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 O-FucT PF10250.9 CCL99964.1 - 2.7e-10 40.5 0.0 3.8e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Glyco_trans_4_4 PF13579.6 CCL99964.1 - 2.2e-06 28.2 0.5 2.2e-06 28.2 0.5 2.8 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CCL99964.1 - 1.5e-05 25.5 0.0 3.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCL99964.1 - 0.00019 21.5 1.6 0.0009 19.3 1.6 2.2 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CCL99964.1 - 0.0056 17.1 0.0 0.017 15.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CCL99964.1 - 0.014 15.0 0.0 0.048 13.2 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferases group 1 Glyco_transf_11 PF01531.16 CCL99964.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 11 PARP PF00644.20 CCL99965.1 - 6.6e-48 162.9 2.9 2.8e-47 160.9 0.0 2.5 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 CCL99965.1 - 1.6e-38 131.9 0.0 2.5e-38 131.3 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 CCL99965.1 - 3e-19 68.8 0.2 3e-19 68.8 0.2 2.5 3 0 0 3 3 3 1 WGR domain PAC1 PF16094.5 CCL99965.1 - 0.53 9.4 0.0 0.53 9.4 0.0 2.1 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 S-antigen PF05756.11 CCL99965.1 - 1.7 9.1 5.0 22 5.5 0.2 2.4 2 0 0 2 2 2 0 S-antigen protein Fasciclin PF02469.22 CCL99966.1 - 1e-24 87.2 3.3 2.7e-16 60.0 0.3 2.5 2 0 0 2 2 2 2 Fasciclin domain SOG2 PF10428.9 CCL99966.1 - 0.47 9.6 18.1 0.67 9.1 18.1 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Pentapeptide_2 PF01469.18 CCL99966.1 - 2.9 7.9 28.3 0.19 11.6 5.2 3.3 2 1 1 3 3 3 0 Pentapeptide repeats (8 copies) MFAP1 PF06991.11 CCL99967.1 - 2.4e-70 236.8 25.6 2.4e-70 236.8 25.6 4.3 2 2 2 4 4 4 1 Microfibril-associated/Pre-mRNA processing Putative_PNPOx PF01243.20 CCL99968.1 - 1.5e-05 25.1 0.0 2.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CCL99969.1 - 0.00016 21.8 0.0 0.00037 20.6 0.0 1.6 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CCL99970.1 - 6.5e-09 35.9 0.0 1.2e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CCL99971.1 - 7.9e-05 22.8 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DEAD PF00270.29 CCL99972.1 - 7.1e-19 68.2 0.0 3e-17 62.9 0.0 2.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCL99972.1 - 1.7e-12 47.7 0.0 1.1e-11 45.1 0.0 2.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCL99972.1 - 0.027 14.5 0.0 0.065 13.2 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Mito_fiss_reg PF05308.11 CCL99972.1 - 2 8.4 9.0 0.6 10.2 4.8 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.19 CCL99972.1 - 4.5 6.7 11.1 3.9 6.9 8.5 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal ECH_1 PF00378.20 CCL99973.1 - 4.5e-40 137.5 0.0 6.5e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCL99973.1 - 2e-21 76.9 0.1 9e-18 64.8 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_C54 PF03416.19 CCL99974.1 - 1.2e-102 343.1 0.0 1.6e-102 342.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 Ras PF00071.22 CCL99975.1 - 4.9e-38 130.3 0.0 1.3e-36 125.6 0.0 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 CCL99975.1 - 1.5e-29 102.6 0.0 2.3e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCL99975.1 - 5.2e-10 39.0 0.0 1.5e-09 37.5 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCL99975.1 - 6.1e-06 26.3 0.0 9.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCL99975.1 - 5e-05 22.8 0.0 0.0001 21.8 0.0 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CCL99975.1 - 8.9e-05 22.1 0.0 0.00075 19.1 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCL99975.1 - 0.0083 16.0 0.0 0.053 13.4 0.1 2.4 4 0 0 4 4 4 1 RsgA GTPase AAA_16 PF13191.6 CCL99975.1 - 0.09 13.2 0.2 0.25 11.7 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CCL99975.1 - 0.12 12.7 0.0 0.53 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 CCL99975.1 - 0.18 11.3 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 CCL99975.1 - 0.22 11.2 0.1 0.46 10.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF3128 PF11326.8 CCL99976.1 - 6.9e-24 84.0 0.6 9.1e-24 83.6 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) FMO-like PF00743.19 CCL99977.1 - 3.1e-20 72.1 0.1 1.4e-14 53.4 0.0 3.0 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCL99977.1 - 6.8e-20 71.5 0.0 3.1e-17 62.8 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCL99977.1 - 7.7e-18 64.7 0.1 1.1e-13 51.1 0.0 2.8 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCL99977.1 - 1.7e-10 41.3 0.1 0.0077 16.8 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCL99977.1 - 4.6e-10 39.2 0.1 2.3e-06 27.0 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CCL99977.1 - 9.7e-06 25.4 0.2 0.054 13.1 0.0 3.2 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCL99977.1 - 1.5e-05 25.1 0.1 0.0023 18.1 0.0 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCL99977.1 - 0.00016 21.1 0.0 0.0045 16.3 0.1 2.7 3 0 0 3 3 3 1 FAD binding domain Amino_oxidase PF01593.24 CCL99977.1 - 0.0013 18.1 0.0 0.55 9.5 0.0 3.0 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CCL99977.1 - 0.0013 18.7 1.2 1.4 8.9 0.1 3.2 2 1 1 3 3 3 2 FAD-NAD(P)-binding HI0933_like PF03486.14 CCL99977.1 - 0.0031 16.3 0.0 0.32 9.7 0.0 3.4 3 0 0 3 3 3 1 HI0933-like protein 2-Hacid_dh_C PF02826.19 CCL99977.1 - 0.0034 16.8 0.0 0.44 9.9 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 CCL99977.1 - 0.005 16.0 0.0 0.18 10.8 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 CCL99977.1 - 0.0061 15.6 0.0 0.015 14.4 0.0 1.6 1 0 0 1 1 1 1 Lycopene cyclase protein IlvN PF07991.12 CCL99977.1 - 0.092 12.3 0.1 0.88 9.1 0.0 2.2 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Oxysterol_BP PF01237.18 CCL99978.1 - 8.3e-133 442.8 0.3 2.2e-132 441.4 0.0 1.9 2 1 0 2 2 2 1 Oxysterol-binding protein Ank_2 PF12796.7 CCL99978.1 - 2.1e-15 57.1 0.6 4.8e-08 33.5 0.1 2.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCL99978.1 - 1.6e-11 44.2 1.9 1.6e-05 25.1 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CCL99978.1 - 1.7e-11 44.0 3.1 0.019 15.4 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 CCL99978.1 - 9.2e-11 42.1 0.6 6.1e-05 23.5 0.2 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) PH PF00169.29 CCL99978.1 - 1.9e-10 41.2 0.4 8.1e-10 39.2 0.0 2.3 2 0 0 2 2 2 1 PH domain Ank_3 PF13606.6 CCL99978.1 - 2.7e-09 36.5 0.5 0.5 11.1 0.1 4.4 4 0 0 4 4 4 3 Ankyrin repeat PH_8 PF15409.6 CCL99978.1 - 8.8e-09 35.5 1.2 1.5e-08 34.8 0.2 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 CCL99978.1 - 0.00031 21.1 0.3 0.0011 19.4 0.3 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain Cpn60_TCP1 PF00118.24 CCL99979.1 - 3.9e-145 484.2 12.7 4.5e-145 484.0 12.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HSL_N PF06350.12 CCL99979.1 - 0.065 12.2 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Hormone-sensitive lipase (HSL) N-terminus RhoGEF67_u2 PF16614.5 CCL99979.1 - 0.17 11.9 0.0 14 5.8 0.0 2.5 2 0 0 2 2 2 0 Unstructured region two on RhoGEF 6 and 7 DUF3808 PF10300.9 CCL99980.1 - 3e-77 260.4 0.0 4.4e-77 259.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_19 PF14559.6 CCL99980.1 - 5.4e-07 30.0 1.0 0.00053 20.4 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCL99980.1 - 3.7e-05 23.9 0.6 3.7e-05 23.9 0.6 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CCL99980.1 - 0.00035 20.2 1.1 0.49 10.3 0.7 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCL99980.1 - 0.00051 20.3 8.2 1.2 9.4 0.0 5.5 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCL99980.1 - 0.0025 17.8 14.2 0.13 12.5 0.4 5.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCL99980.1 - 0.0029 18.2 0.0 0.0029 18.2 0.0 4.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCL99980.1 - 0.027 15.1 3.7 3.5 8.4 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCL99980.1 - 0.036 14.1 5.5 5.5 7.3 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCL99980.1 - 0.038 14.8 9.6 58 4.9 0.0 5.8 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCL99980.1 - 0.22 11.9 8.8 0.72 10.2 0.6 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCL99980.1 - 2.4 8.2 6.9 20 5.2 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat CoaE PF01121.20 CCL99981.1 - 1.3e-63 213.9 0.0 1.6e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 CCL99981.1 - 9.9e-07 29.4 0.0 1.1e-05 26.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCL99981.1 - 0.0015 18.7 0.0 0.0047 17.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCL99981.1 - 0.0033 17.9 0.0 0.044 14.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CCL99981.1 - 0.042 14.1 0.0 0.084 13.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain Guanylate_kin PF00625.21 CCL99981.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Guanylate kinase dNK PF01712.19 CCL99981.1 - 0.21 11.4 0.0 6.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase LSM14 PF12701.7 CCL99984.1 - 2.4e-25 88.4 0.0 4.3e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 CCL99984.1 - 3.2e-07 31.2 3.0 3.2e-07 31.2 3.0 1.9 2 1 0 2 2 2 1 FDF domain SM-ATX PF14438.6 CCL99984.1 - 0.00019 21.5 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain TFIIA PF03153.13 CCL99984.1 - 0.018 15.1 3.7 0.019 15.0 3.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arrestin_C PF02752.22 CCL99985.1 - 4.4e-10 40.1 0.0 1e-07 32.5 0.0 2.8 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 CCL99985.1 - 0.00055 19.7 0.0 0.0018 18.0 0.0 1.7 2 0 0 2 2 2 1 Arrestin_N terminal like Arrestin_N PF00339.29 CCL99985.1 - 0.0021 18.1 0.0 0.014 15.4 0.0 2.4 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain VGCC_beta4Aa_N PF12052.8 CCL99985.1 - 0.14 12.3 3.4 23 5.2 0.2 3.5 3 0 0 3 3 3 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal HSF_DNA-bind PF00447.17 CCL99986.1 - 9.9e-33 112.6 0.3 1.9e-32 111.7 0.3 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding POTRA_3 PF17287.2 CCL99986.1 - 0.13 11.8 0.0 0.5 9.9 0.0 2.0 1 0 0 1 1 1 0 POTRA domain COG6 PF06419.11 CCL99987.1 - 4.1e-151 504.3 0.0 5.7e-151 503.8 0.0 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DUF1409 PF07197.12 CCL99987.1 - 0.12 12.2 0.0 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1409) DUF1664 PF07889.12 CCL99987.1 - 0.18 11.9 1.5 0.37 10.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Coa1 PF08695.10 CCL99988.1 - 6.2e-31 106.6 0.0 7.7e-31 106.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF4488 PF14869.6 CCL99988.1 - 0.058 13.3 0.0 2.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4488) E1_dh PF00676.20 CCL99989.1 - 1.8e-110 368.6 0.0 2.2e-110 368.3 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CCL99989.1 - 0.0003 20.6 1.1 0.00062 19.6 1.1 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CCL99989.1 - 0.0044 16.3 0.0 0.0078 15.4 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DUF4873 PF16170.5 CCL99989.1 - 0.071 13.3 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4873) Thiamine_BP PF01910.17 CCL99990.1 - 3.6e-23 81.3 0.0 5.5e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 Thiamine-binding protein Arm PF00514.23 CCL99991.1 - 2.2e-11 43.4 7.6 3.4e-05 23.7 0.1 5.8 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CCL99991.1 - 4.9e-07 30.0 12.3 0.55 10.7 0.2 7.5 7 2 0 8 8 8 1 HEAT repeats Adaptin_N PF01602.20 CCL99991.1 - 6.2e-05 21.7 1.0 0.24 9.9 0.2 3.5 2 1 1 4 4 4 2 Adaptin N terminal region HEAT PF02985.22 CCL99991.1 - 8.5e-05 22.5 14.8 2 8.9 0.0 7.7 8 0 0 8 8 8 2 HEAT repeat Cnd1 PF12717.7 CCL99991.1 - 0.00013 22.0 4.2 0.033 14.2 0.2 4.3 3 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Atx10homo_assoc PF09759.9 CCL99991.1 - 0.0014 18.6 0.8 0.12 12.4 0.2 3.5 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 CCL99991.1 - 0.0096 16.4 11.7 0.43 11.1 0.0 6.8 9 1 0 9 9 9 1 HEAT-like repeat CLASP_N PF12348.8 CCL99991.1 - 0.019 14.5 0.1 0.11 12.1 0.0 2.4 3 0 0 3 3 3 0 CLASP N terminal DUF3361 PF11841.8 CCL99991.1 - 0.03 14.3 0.4 2.7 7.9 0.2 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) Cohesin_HEAT PF12765.7 CCL99991.1 - 0.19 12.1 1.0 24 5.3 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion DNA_methylase PF00145.17 CCL99992.1 - 4.6e-41 141.3 0.0 1.6e-40 139.5 0.0 1.9 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 CCL99992.1 - 9.2e-05 22.3 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 BAH domain Gag_MA PF01140.19 CCL99992.1 - 0.45 10.2 2.6 18 5.1 0.0 2.9 3 0 0 3 3 3 0 Matrix protein (MA), p15 MCM PF00493.23 CCL99994.1 - 2.1e-104 347.5 0.0 5.6e-104 346.1 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 CCL99994.1 - 3.1e-31 107.8 0.6 5.6e-31 107.0 0.6 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCL99994.1 - 7.6e-21 74.3 1.0 2.1e-20 72.9 1.0 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCL99994.1 - 7.2e-19 68.3 0.7 2.6e-18 66.5 0.7 2.1 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 CCL99994.1 - 3e-08 33.7 0.0 7.2e-07 29.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CCL99994.1 - 1.3e-07 31.3 0.1 1.1e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Mg_chelatase_C PF13335.6 CCL99994.1 - 0.0081 16.8 1.8 0.015 15.9 0.1 2.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 CCL99994.1 - 0.021 14.7 0.0 0.064 13.1 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PI-TkoII_IV PF18714.1 CCL99994.1 - 0.083 12.3 0.6 0.2 11.1 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase II intein Domain IV Sigma54_activat PF00158.26 CCL99994.1 - 0.095 12.4 0.1 0.7 9.6 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Peptidase_S8 PF00082.22 CCL99995.1 - 2e-33 116.0 1.2 3e-33 115.4 1.2 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 CCL99995.1 - 6.4e-26 90.2 0.5 1.4e-25 89.1 0.5 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 CCL99995.1 - 0.012 16.4 0.4 0.063 14.1 0.3 2.2 1 1 0 1 1 1 0 Peptidase S8 pro-domain SKG6 PF08693.10 CCL99995.1 - 0.84 9.1 4.2 2 7.9 4.2 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain POT1PC PF16686.5 CCL99996.1 - 1.1e-20 74.0 1.5 3.7e-09 36.6 0.1 4.4 2 2 0 2 2 2 2 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 CCL99996.1 - 2.5e-09 37.1 0.0 1.1e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 DZR PF12773.7 CCL99996.1 - 0.023 14.7 1.0 0.06 13.4 1.0 1.7 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 CCL99996.1 - 0.047 13.4 1.5 0.12 12.2 1.5 1.7 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 CCL99996.1 - 0.055 14.2 1.0 0.13 13.0 1.0 1.6 1 0 0 1 1 1 0 zinc-ribbon family TAP42 PF04177.12 CCL99997.1 - 9.3e-84 281.3 1.9 1.1e-83 281.1 1.9 1.0 1 0 0 1 1 1 1 TAP42-like family Ras PF00071.22 CCL99998.1 - 3.4e-58 195.8 0.4 4.1e-58 195.6 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCL99998.1 - 2.9e-36 124.3 0.1 4.9e-36 123.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCL99998.1 - 1.8e-15 56.9 0.1 2.2e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCL99998.1 - 3e-06 26.9 0.3 7e-05 22.5 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCL99998.1 - 3.8e-06 26.4 0.5 4.7e-06 26.1 0.5 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CCL99998.1 - 1.4e-05 24.6 0.2 5.5e-05 22.7 0.0 1.7 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCL99998.1 - 2.2e-05 24.5 0.0 5.1e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCL99998.1 - 3.5e-05 23.8 0.1 0.02 14.8 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CCL99998.1 - 0.0024 17.4 0.0 0.64 9.5 0.1 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B CPT PF07931.12 CCL99998.1 - 0.0083 16.0 0.0 0.071 12.9 0.0 2.3 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein TniB PF05621.11 CCL99998.1 - 0.011 15.1 0.0 0.18 11.2 0.0 2.4 3 0 0 3 3 3 0 Bacterial TniB protein PduV-EutP PF10662.9 CCL99998.1 - 0.029 14.1 1.0 0.18 11.6 1.0 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 CCL99998.1 - 0.048 13.7 0.0 2.7 8.0 0.0 2.6 2 1 0 2 2 2 0 Dynamin family MTHFR PF02219.17 CCL99999.1 - 3.5e-107 358.0 0.0 5e-107 357.5 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase TMP-TENI PF02581.17 CCL99999.1 - 0.047 13.0 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 Thiamine monophosphate synthase EPL1 PF10513.9 CCM00001.1 - 1e-22 81.2 0.5 1e-22 81.2 0.5 2.4 2 0 0 2 2 2 1 Enhancer of polycomb-like Transket_pyr PF02779.24 CCM00003.1 - 6.8e-39 133.4 0.1 1.1e-38 132.7 0.1 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCM00003.1 - 1.8e-23 82.8 0.0 5.1e-23 81.3 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain PI3Ka PF00613.20 CCM00003.1 - 2.3e-20 72.8 0.0 4.5e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 CCM00003.1 - 1.1e-15 58.2 0.1 3.5e-09 36.9 0.0 3.4 2 1 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase RdRP PF05183.12 CCM00004.1 - 5.5e-182 606.5 0.0 7.1e-182 606.1 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Peptidase_M28 PF04389.17 CCM00004.1 - 6.2e-36 124.0 0.4 2.6e-35 121.9 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M28 Ydr279_N PF17745.1 CCM00005.1 - 0.06 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Ydr279p protein triple barrel domain Sybindin PF04099.12 CCM00006.1 - 7.3e-40 136.2 0.0 8e-40 136.1 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CCM00006.1 - 1.4e-08 35.0 0.0 1.4e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region TATR PF03430.13 CCM00006.1 - 0.23 9.8 0.0 0.27 9.6 0.0 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator HORMA PF02301.18 CCM00007.1 - 6e-68 228.6 0.0 1.1e-67 227.8 0.0 1.4 1 0 0 1 1 1 1 HORMA domain PFU PF09070.11 CCM00008.1 - 1.9e-44 150.5 0.1 3.8e-44 149.5 0.1 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 CCM00008.1 - 4.2e-43 147.6 1.0 5.4e-43 147.2 1.0 1.1 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 CCM00008.1 - 6e-34 115.5 15.7 5e-08 33.5 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 CCM00008.1 - 7.8e-05 22.7 0.0 0.38 10.8 0.0 2.8 1 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region DUF2587 PF10759.9 CCM00008.1 - 0.075 12.6 0.0 0.28 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2587) His_Phos_1 PF00300.22 CCM00009.1 - 9.1e-32 110.3 0.1 1.9e-31 109.3 0.1 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Glyoxal_oxid_N PF07250.11 CCM00010.1 - 7.2e-33 113.8 0.0 8.3e-32 110.3 0.0 2.6 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 CCM00010.1 - 2e-21 76.1 0.2 9.6e-21 73.9 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1929) CE2_N PF17996.1 CCM00010.1 - 0.00055 19.9 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Kelch_4 PF13418.6 CCM00010.1 - 0.17 11.9 2.7 10 6.3 0.0 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain KH_8 PF17903.1 CCM00011.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Krr1 KH1 domain KH_1 PF00013.29 CCM00011.1 - 0.012 15.4 0.6 0.025 14.4 0.6 1.5 1 0 0 1 1 1 0 KH domain SWIRM-assoc_2 PF16496.5 CCM00011.1 - 0.11 11.3 2.1 0.17 10.7 2.1 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal DUF3835 PF12927.7 CCM00012.1 - 0.079 13.8 0.2 0.14 13.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3835) Glyco_transf_22 PF03901.17 CCM00013.1 - 1.1e-93 314.8 19.5 1.4e-93 314.4 19.5 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family F-box-like PF12937.7 CCM00014.1 - 0.0071 16.2 5.2 0.11 12.5 5.2 2.6 1 1 0 1 1 1 1 F-box-like DUF1713 PF08213.11 CCM00015.1 - 9.5e-09 35.0 23.0 1.4e-08 34.5 23.0 1.2 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Ribosomal_L7Ae PF01248.26 CCM00017.1 - 2e-11 43.5 0.0 2.3e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 CCM00017.1 - 0.023 14.7 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 RNase P subunit Pop3 PELOTA_1 PF15608.6 CCM00017.1 - 0.094 12.6 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 PELOTA RNA binding domain UQ_con PF00179.26 CCM00018.1 - 1.2e-44 151.3 0.0 1.4e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCM00018.1 - 0.00031 20.5 0.0 0.00038 20.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B Methyltransf_31 PF13847.6 CCM00019.1 - 3.1e-07 30.3 0.0 7.3e-07 29.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM00019.1 - 1e-06 28.7 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00019.1 - 1.1e-06 29.2 0.0 2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM00019.1 - 9.7e-06 26.3 0.0 1.6e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM00019.1 - 3.5e-05 24.4 0.0 7.3e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 CCM00019.1 - 0.002 17.6 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_29 PF03141.16 CCM00019.1 - 0.024 13.2 0.0 0.033 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Meis_PKNOX_N PF16493.5 CCM00019.1 - 0.2 12.0 0.0 0.38 11.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal of Homeobox Meis and PKNOX1 Proteasome PF00227.26 CCM00020.1 - 3.7e-51 173.3 0.1 4.6e-51 173.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Syja_N PF02383.18 CCM00021.1 - 1.9e-94 316.6 0.0 2.7e-94 316.1 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 CCM00021.1 - 7.6e-33 112.7 0.0 1.8e-32 111.4 0.0 1.7 2 0 0 2 2 2 1 Inositol phosphatase Cofilin_ADF PF00241.20 CCM00021.1 - 0.02 14.7 0.1 0.046 13.5 0.1 1.7 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein Myosin_TH1 PF06017.13 CCM00021.1 - 0.057 13.1 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding DHHC PF01529.20 CCM00022.1 - 8.3e-07 29.2 21.1 1.8e-05 24.9 6.8 2.5 2 1 1 3 3 3 2 DHHC palmitoyltransferase McyA_C PF12593.8 CCM00022.1 - 0.014 15.2 0.1 0.039 13.7 0.1 1.7 1 0 0 1 1 1 0 Microcystin synthetase C terminal Amidase PF01425.21 CCM00023.1 - 1.2e-99 334.4 0.0 1.6e-99 333.9 0.0 1.2 1 0 0 1 1 1 1 Amidase DUF953 PF06110.11 CCM00024.1 - 7.5e-19 67.5 0.0 8.8e-19 67.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) LamB_YcsF PF03746.16 CCM00025.1 - 6.2 6.4 13.5 9.9 5.8 1.6 3.3 1 1 2 3 3 3 0 LamB/YcsF family Mito_carr PF00153.27 CCM00026.1 - 1.5e-61 204.3 1.3 2.5e-23 81.8 0.1 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 CCM00026.1 - 1.5e-17 63.8 3.4 2.6e-07 31.0 0.2 4.7 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 CCM00026.1 - 5.4e-17 60.2 1.8 2.1e-05 24.0 0.2 5.9 7 0 0 7 7 7 3 EF-hand domain EF-hand_1 PF00036.32 CCM00026.1 - 2.4e-16 58.0 4.7 2.8e-05 23.4 0.1 6.3 7 0 0 7 7 7 3 EF hand EF-hand_8 PF13833.6 CCM00026.1 - 7.5e-08 32.1 4.5 0.026 14.4 0.0 4.9 5 1 2 7 7 7 2 EF-hand domain pair EF-hand_5 PF13202.6 CCM00026.1 - 9e-08 31.3 6.5 0.0012 18.2 0.2 4.2 5 0 0 5 5 5 2 EF hand Met_10 PF02475.16 CCM00027.1 - 4.9e-63 212.5 0.0 8e-63 211.8 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 CCM00027.1 - 0.025 13.7 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.15 CCM00027.1 - 0.026 14.2 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase TatD_DNase PF01026.21 CCM00028.1 - 4.8e-21 75.3 0.0 6.7e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase V-SNARE_C PF12352.8 CCM00029.1 - 8e-15 54.9 4.5 1.1e-14 54.5 0.6 2.9 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Laminin_I PF06008.14 CCM00029.1 - 0.00049 19.9 0.6 0.0019 17.9 0.6 1.8 2 0 0 2 2 2 1 Laminin Domain I VP4_helical PF17478.2 CCM00029.1 - 0.0036 16.8 1.7 0.81 9.1 0.3 2.1 1 1 1 2 2 2 2 Rotavirus VP4 helical domain CK2S PF15011.6 CCM00029.1 - 0.012 15.5 0.9 0.032 14.1 0.9 1.8 1 1 0 1 1 1 0 Casein Kinase 2 substrate Med30 PF11315.8 CCM00029.1 - 0.012 15.8 0.1 0.054 13.7 0.0 2.0 1 1 1 2 2 2 0 Mediator complex subunit 30 TipAS PF07739.13 CCM00029.1 - 0.015 15.8 0.5 0.035 14.6 0.3 1.7 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain Laminin_II PF06009.12 CCM00029.1 - 0.023 14.7 2.6 0.45 10.5 2.0 2.6 2 1 0 2 2 2 0 Laminin Domain II FlgN PF05130.12 CCM00029.1 - 0.03 14.8 1.2 0.057 13.9 1.2 1.4 1 1 0 1 1 1 0 FlgN protein APG6_N PF17675.1 CCM00029.1 - 0.033 14.7 5.5 0.26 11.8 4.2 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Occludin_ELL PF07303.13 CCM00029.1 - 0.043 14.5 0.3 0.67 10.7 0.2 2.4 1 1 1 2 2 2 0 Occludin homology domain Spectrin PF00435.21 CCM00029.1 - 0.047 14.2 1.7 0.44 11.1 1.6 2.3 1 1 1 2 2 2 0 Spectrin repeat MHB PF16525.5 CCM00029.1 - 0.06 13.6 0.1 3.5 7.9 0.0 2.7 2 1 0 2 2 2 0 Haemophore, haem-binding Mid2 PF04478.12 CCM00029.1 - 0.067 13.0 0.9 0.11 12.3 0.9 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Jnk-SapK_ap_N PF09744.9 CCM00029.1 - 0.076 13.2 0.6 0.13 12.5 0.6 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 WXG100 PF06013.12 CCM00029.1 - 0.11 12.7 1.2 8.2 6.7 0.0 3.1 2 1 0 3 3 3 0 Proteins of 100 residues with WXG GrpE PF01025.19 CCM00029.1 - 0.13 11.9 1.1 0.21 11.3 1.0 1.5 1 1 0 1 1 1 0 GrpE Ada3 PF10198.9 CCM00029.1 - 0.15 12.2 3.2 0.21 11.8 2.0 1.5 1 1 0 1 1 1 0 Histone acetyltransferases subunit 3 BST2 PF16716.5 CCM00029.1 - 0.2 12.3 2.1 19 5.9 0.1 3.2 3 1 0 3 3 3 0 Bone marrow stromal antigen 2 FTA4 PF13093.6 CCM00029.1 - 0.26 11.1 3.7 0.49 10.2 3.7 1.5 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 MerR-DNA-bind PF09278.11 CCM00029.1 - 0.6 10.7 3.6 0.8 10.3 0.6 2.7 3 1 0 3 3 3 0 MerR, DNA binding Baculo_PEP_C PF04513.12 CCM00029.1 - 0.68 10.0 4.9 0.65 10.0 0.9 2.3 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CorA PF01544.18 CCM00029.1 - 1.3 8.2 5.7 2 7.7 5.0 1.6 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein FUSC PF04632.12 CCM00029.1 - 2 6.9 8.6 0.6 8.6 6.2 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family Clostridium_P47 PF06597.11 CCM00030.1 - 0.041 12.6 5.9 0.052 12.3 5.9 1.1 1 0 0 1 1 1 0 Clostridium P-47 protein SseC PF04888.12 CCM00030.1 - 0.25 10.9 7.8 0.35 10.4 7.8 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF2207 PF09972.9 CCM00030.1 - 1.4 7.6 3.0 1.5 7.4 3.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4231 PF14015.6 CCM00030.1 - 9.7 6.7 6.2 14 6.2 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Syndecan PF01034.20 CCM00031.1 - 0.11 12.4 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Syndecan domain Proteasome PF00227.26 CCM00032.1 - 7.2e-25 87.6 0.0 1.1e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Maf_N PF08383.11 CCM00032.1 - 0.017 14.9 0.5 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Maf N-terminal region G6B PF15096.6 CCM00033.1 - 0.0047 16.7 0.4 0.016 15.0 0.0 2.0 1 1 1 2 2 2 1 G6B family Mid2 PF04478.12 CCM00033.1 - 0.029 14.2 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor STE3 PF02076.15 CCM00033.1 - 0.077 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Pheromone A receptor DUF2407_C PF13373.6 CCM00033.1 - 0.082 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain JmjC PF02373.22 CCM00034.1 - 6.5e-38 129.7 0.1 1.2e-37 128.8 0.1 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 CCM00034.1 - 8.5e-16 57.6 0.2 1.7e-15 56.7 0.2 1.5 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H PF13771.6 CCM00034.1 - 1.5e-12 47.6 0.8 3.8e-12 46.3 0.8 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CCM00034.1 - 1e-10 41.7 0.4 2.8e-10 40.3 0.4 1.7 1 0 0 1 1 1 1 PHD-zinc-finger like domain PHD PF00628.29 CCM00034.1 - 0.005 16.7 2.7 0.012 15.5 2.7 1.7 1 0 0 1 1 1 1 PHD-finger DUF1454 PF07305.12 CCM00034.1 - 0.091 12.2 1.3 0.23 10.9 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1454) FHA PF00498.26 CCM00035.1 - 0.00011 22.5 0.0 0.0003 21.1 0.0 1.9 1 0 0 1 1 1 1 FHA domain CAP59_mtransfer PF11735.8 CCM00036.1 - 1.4e-35 123.1 0.0 2.6e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Ac76 PF05814.11 CCM00036.1 - 0.031 14.3 0.6 0.073 13.1 0.6 1.5 1 0 0 1 1 1 0 Orf76 (Ac76) OTCace_N PF02729.21 CCM00037.1 - 1.4e-44 151.7 0.0 2.1e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CCM00037.1 - 1.4e-43 148.7 0.0 1.9e-43 148.3 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Glycogen_syn PF05693.13 CCM00038.1 - 0 1093.4 0.0 0 1093.2 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_trans_1_4 PF13692.6 CCM00038.1 - 4.5e-07 30.4 0.0 0.00065 20.1 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CCM00038.1 - 6e-07 29.2 0.0 0.00056 19.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 CCM00038.1 - 1e-06 28.7 1.1 1.5e-06 28.1 0.1 1.9 2 0 0 2 2 2 1 Starch synthase catalytic domain Glyco_transf_4 PF13439.6 CCM00038.1 - 8.6e-05 22.6 0.3 0.00017 21.6 0.3 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CCM00038.1 - 9.2e-05 22.9 0.1 0.00019 21.9 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Aldo_ket_red PF00248.21 CCM00039.1 - 2.2e-41 142.0 0.0 6e-40 137.3 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.32 CCM00040.1 - 4.6e-07 30.4 0.2 0.16 12.9 0.0 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat F-box-like PF12937.7 CCM00040.1 - 1.3e-05 24.9 1.0 0.00025 20.9 0.1 2.4 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 CCM00040.1 - 0.002 18.4 0.0 1 9.7 0.0 3.3 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 CCM00040.1 - 0.029 14.3 0.2 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 F-box domain Ank_2 PF12796.7 CCM00041.1 - 0.013 16.1 0.0 0.061 13.9 0.0 2.1 3 0 0 3 3 3 0 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM00041.1 - 0.044 14.1 0.3 0.14 12.5 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.30 CCM00041.1 - 0.066 13.7 0.5 2 9.0 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeat Acetyltransf_1 PF00583.25 CCM00041.1 - 0.071 13.4 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HET PF06985.11 CCM00042.1 - 5.8e-09 36.5 1.6 7.1e-06 26.4 0.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) CHAT PF12770.7 CCM00043.1 - 1.9e-34 119.4 0.0 3.6e-34 118.5 0.0 1.5 1 0 0 1 1 1 1 CHAT domain TPR_10 PF13374.6 CCM00043.1 - 7.8e-09 35.1 7.6 0.15 12.0 0.1 6.2 5 0 0 5 5 5 3 Tetratricopeptide repeat AAA_lid_7 PF17867.1 CCM00043.1 - 0.075 13.2 0.0 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 Midasin AAA lid domain Flp_Fap PF04964.14 CCM00043.1 - 0.14 12.0 0.4 71 3.3 0.0 4.1 5 0 0 5 5 5 0 Flp/Fap pilin component Anillin_N PF16018.5 CCM00043.1 - 0.27 11.9 0.8 15 6.3 0.1 3.5 2 2 1 3 3 3 0 Anillin N-terminus GTP_cyclohydro2 PF00925.20 CCM00044.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase II Pkinase PF00069.25 CCM00045.1 - 9.4e-64 215.3 0.0 1.3e-63 214.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00045.1 - 7.8e-30 104.0 0.0 1.1e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCM00045.1 - 1.6e-05 24.1 0.0 2.4e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCM00045.1 - 0.0018 18.2 0.0 0.0042 17.0 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCM00045.1 - 0.0026 17.1 0.0 0.0062 15.9 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCM00045.1 - 0.029 14.0 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 CCM00045.1 - 0.032 13.6 0.0 0.077 12.3 0.0 1.6 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.22 CCM00045.1 - 0.072 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family NAD_binding_1 PF00175.21 CCM00046.1 - 3.4e-29 101.7 0.0 5.5e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCM00046.1 - 2e-17 63.3 0.0 5.9e-17 61.9 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCM00046.1 - 2.8e-07 30.8 0.0 7.9e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain DUF4101 PF13355.6 CCM00046.1 - 0.04 14.4 0.0 0.079 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4101) CPSase_L_D2 PF02786.17 CCM00047.1 - 1.1e-69 234.2 0.0 2e-69 233.3 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCM00047.1 - 4.8e-47 159.1 0.3 1.9e-46 157.1 0.1 2.0 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCM00047.1 - 3.1e-32 110.9 0.0 1e-24 86.7 0.0 2.5 1 1 1 2 2 2 2 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCM00047.1 - 2.5e-16 59.2 5.6 5.2e-16 58.2 5.6 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CCM00047.1 - 3.2e-08 33.4 0.0 7.2e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CCM00047.1 - 1.3e-07 31.3 2.4 1.2e-06 28.2 1.3 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like ATP-grasp PF02222.22 CCM00047.1 - 3.1e-07 30.1 0.0 9.9e-07 28.5 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain HlyD_D23 PF16576.5 CCM00047.1 - 5.3e-05 22.5 0.4 0.21 10.8 0.1 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CCM00047.1 - 0.00027 21.6 0.8 0.58 10.9 0.2 2.6 2 0 0 2 2 2 2 HlyD family secretion protein PYNP_C PF07831.13 CCM00047.1 - 0.037 13.7 1.5 0.12 12.0 0.6 2.2 1 1 1 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain Urate_ox_N PF06181.11 CCM00047.1 - 0.046 13.1 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Urate oxidase N-terminal ATP-grasp_4 PF13535.6 CCM00047.1 - 0.078 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain DUF2118 PF09891.9 CCM00047.1 - 0.08 12.9 1.4 0.22 11.5 1.1 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) GCV_H PF01597.19 CCM00047.1 - 0.12 12.2 0.3 0.24 11.3 0.3 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein NQRA PF05896.11 CCM00047.1 - 0.18 11.2 0.7 0.35 10.3 0.7 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) UCH PF00443.29 CCM00049.1 - 1.2e-37 129.9 0.0 6.3e-37 127.5 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 CCM00049.1 - 3.2e-22 78.2 0.4 2.7e-16 59.2 0.1 2.7 2 0 0 2 2 2 2 A repeated domain in UCH-protein UCH_1 PF13423.6 CCM00049.1 - 1.4e-08 34.7 0.3 0.00047 19.9 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Fes1 PF08609.10 CCM00049.1 - 0.096 13.6 0.2 0.68 10.9 0.1 2.6 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 DUF2242 PF10001.9 CCM00050.1 - 0.21 11.7 0.0 0.36 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2242) SwrA PF17423.2 CCM00051.1 - 0.019 14.9 0.2 0.074 13.0 0.1 2.1 2 1 0 2 2 2 0 Swarming motility protein AraC_N PF06719.13 CCM00051.1 - 0.19 11.4 0.2 12 5.5 0.1 2.3 2 0 0 2 2 2 0 AraC-type transcriptional regulator N-terminus DUF3292 PF11696.8 CCM00052.1 - 6e-229 761.7 0.0 7.2e-229 761.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) PRT_C PF08372.10 CCM00052.1 - 0.064 13.0 0.0 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 CCM00052.1 - 0.093 12.1 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) Sel1 PF08238.12 CCM00053.1 - 6.1e-47 157.0 17.3 2.7e-08 34.2 0.2 7.9 8 0 0 8 8 8 7 Sel1 repeat TPR_5 PF12688.7 CCM00053.1 - 0.058 13.6 0.0 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 Tetratrico peptide repeat HNH_repeat PF18780.1 CCM00053.1 - 1.4 8.7 0.0 1.4 8.7 0.0 3.1 3 0 0 3 3 3 0 Homing endonuclease repeat ADH_zinc_N PF00107.26 CCM00054.1 - 5.5e-25 87.8 0.2 8.6e-25 87.2 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM00054.1 - 1.5e-18 68.1 0.0 2.5e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM00054.1 - 4.1e-12 45.9 0.3 1.1e-11 44.5 0.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ELFV_dehydrog PF00208.21 CCM00054.1 - 0.033 13.9 0.1 0.051 13.3 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ADH_N_2 PF16884.5 CCM00054.1 - 0.07 13.0 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase BAG PF02179.16 CCM00055.1 - 2.6e-20 72.6 0.0 4.2e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 CCM00055.1 - 1.4e-09 37.5 0.0 2.4e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Pkinase PF00069.25 CCM00056.1 - 2.3e-56 191.1 0.0 3.1e-56 190.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00056.1 - 3.1e-37 128.3 0.0 4.4e-37 127.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM00056.1 - 4.6e-07 29.4 0.0 7.3e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCM00056.1 - 0.00085 19.3 0.1 0.4 10.6 0.0 3.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCM00056.1 - 0.019 14.0 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 CCM00056.1 - 0.026 13.3 0.0 0.045 12.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Got1 PF04178.12 CCM00057.1 - 8.7e-19 68.0 13.0 1.1e-18 67.7 13.0 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family CPP1-like PF11833.8 CCM00057.1 - 0.44 10.2 3.2 0.54 9.9 3.2 1.1 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF308 PF03729.13 CCM00057.1 - 6.5 7.2 18.5 4.6 7.7 11.0 2.3 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) zf-TRAF PF02176.18 CCM00058.1 - 0.0025 18.5 2.7 0.08 13.6 0.3 2.3 1 1 1 2 2 2 2 TRAF-type zinc finger zf-ACC PF17848.1 CCM00058.1 - 0.088 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain MFS_1 PF07690.16 CCM00059.1 - 9.2e-39 133.3 32.0 9.2e-39 133.3 32.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily FPN1 PF06963.12 CCM00059.1 - 0.071 11.7 0.0 0.071 11.7 0.0 2.6 3 0 0 3 3 3 0 Ferroportin1 (FPN1) tRNA-synt_1 PF00133.22 CCM00060.1 - 9.7e-219 727.6 0.0 2.1e-218 726.5 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCM00060.1 - 2.6e-27 95.6 0.0 6.8e-27 94.3 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCM00060.1 - 6.7e-13 48.2 0.3 1.6e-05 23.9 0.1 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) Albumin_I PF08027.11 CCM00060.1 - 0.13 11.9 0.3 0.37 10.4 0.3 1.8 1 0 0 1 1 1 0 Albumin I chain b zf-C2H2_jaz PF12171.8 CCM00061.1 - 5.3e-07 29.8 0.0 9.6e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM00061.1 - 2.8e-06 27.5 0.1 5.1e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 CCM00061.1 - 0.00046 20.2 2.9 0.0014 18.7 2.9 1.9 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins zf-DBF PF07535.12 CCM00061.1 - 0.0029 17.7 0.0 0.0055 16.8 0.0 1.4 1 0 0 1 1 1 1 DBF zinc finger Atg14 PF10186.9 CCM00061.1 - 0.0069 15.5 0.3 0.0069 15.5 0.3 2.1 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 zf-C2H2 PF00096.26 CCM00061.1 - 0.13 12.8 0.4 0.23 12.0 0.4 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type Ribosomal_L11_N PF03946.14 CCM00062.1 - 5.3e-23 80.6 0.1 8.6e-23 80.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CCM00062.1 - 2.4e-17 63.2 0.7 3.9e-17 62.5 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Cyclin PF08613.11 CCM00063.1 - 2.3e-17 63.8 0.0 3.3e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin Pkinase PF00069.25 CCM00064.1 - 3.5e-32 111.8 0.0 6.4e-30 104.4 0.0 3.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00064.1 - 3.6e-17 62.5 0.0 6.3e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM00064.1 - 0.1 11.9 0.0 0.24 10.7 0.0 1.5 1 1 0 1 1 1 0 Kinase-like U3_assoc_6 PF08640.11 CCM00065.1 - 2.6e-31 107.5 3.1 2.8e-29 101.0 0.6 2.8 3 0 0 3 3 3 2 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 CCM00065.1 - 0.00017 22.1 5.0 0.62 11.0 0.1 6.0 5 1 1 6 6 6 2 Tetratricopeptide repeat NRDE-2 PF08424.10 CCM00065.1 - 0.0002 20.6 1.1 0.021 14.0 0.0 2.9 2 1 1 3 3 3 2 NRDE-2, necessary for RNA interference Arg_decarbox_C PF17944.1 CCM00065.1 - 0.46 11.1 1.8 2.1 9.0 0.4 2.8 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension F-box-like PF12937.7 CCM00067.1 - 8.9e-06 25.5 0.0 2.7e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM00067.1 - 1.7e-05 24.5 0.0 4.6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 F-box domain DUF1054 PF06335.12 CCM00067.1 - 0.07 13.1 1.1 0.16 11.9 0.6 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1054) RNase_H PF00075.24 CCM00068.1 - 5.9e-09 36.2 0.0 1.1e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 CCM00068.1 - 0.057 13.2 0.1 0.34 10.7 0.0 2.2 1 1 1 2 2 2 0 Reverse transcriptase-like Glyco_transf_22 PF03901.17 CCM00069.1 - 2.3e-38 132.5 16.1 3.1e-38 132.1 16.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family ABC2_membrane PF01061.24 CCM00070.1 - 2.6e-33 115.2 20.5 4.7e-33 114.4 20.5 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CCM00070.1 - 6e-29 101.3 0.0 1.1e-28 100.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCM00070.1 - 0.00012 22.0 0.0 0.52 10.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system EGF_2 PF07974.13 CCM00070.1 - 0.00021 21.6 12.3 0.00021 21.6 12.3 3.5 3 0 0 3 3 2 2 EGF-like domain AAA_29 PF13555.6 CCM00070.1 - 0.0014 18.3 0.1 0.004 16.9 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CCM00070.1 - 0.0033 16.9 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CCM00070.1 - 0.0037 17.2 0.0 0.0071 16.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase Rad17 PF03215.15 CCM00070.1 - 0.0042 17.0 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CCM00070.1 - 0.11 12.8 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CCM00070.1 - 0.17 12.4 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCM00070.1 - 0.19 12.0 0.0 0.43 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain FA_hydroxylase PF04116.13 CCM00071.1 - 2.4e-23 82.9 30.4 2.8e-22 79.5 24.5 2.3 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily DnaJ_C PF01556.18 CCM00072.1 - 5.6e-38 130.3 0.0 8e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCM00072.1 - 3e-19 68.9 2.9 5e-19 68.2 2.9 1.4 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 CCM00073.1 - 2.2e-11 44.1 10.2 0.0028 18.5 0.2 5.4 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00073.1 - 1.1e-05 25.6 0.0 1.3 9.3 0.0 4.8 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM00073.1 - 0.045 12.7 0.0 0.37 9.7 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCM00073.1 - 0.064 11.9 0.1 0.84 8.2 0.0 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 SIR2 PF02146.17 CCM00074.1 - 8.3e-31 107.3 0.0 5.2e-21 75.4 0.0 2.4 2 1 0 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 CCM00074.1 - 0.066 13.0 0.1 3.6 7.3 0.2 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Zn-ribbon_8 PF09723.10 CCM00074.1 - 0.087 13.0 0.5 0.21 11.7 0.5 1.6 1 0 0 1 1 1 0 Zinc ribbon domain WD40 PF00400.32 CCM00075.1 - 1.2e-18 67.1 6.4 0.0011 19.7 0.1 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00075.1 - 1.2e-10 41.6 0.0 4.6e-08 33.3 0.0 4.3 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM00075.1 - 0.0027 16.7 0.0 0.071 12.1 0.0 2.3 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCM00075.1 - 0.011 15.1 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Nup160 PF11715.8 CCM00075.1 - 0.043 12.5 0.1 0.96 8.0 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DSS1_SEM1 PF05160.13 CCM00076.1 - 3.5e-23 81.4 6.6 4.7e-23 81.0 6.6 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family F-box-like PF12937.7 CCM00077.1 - 0.075 12.9 2.3 0.23 11.4 2.3 1.8 1 0 0 1 1 1 0 F-box-like GEMIN8 PF15348.6 CCM00077.1 - 0.11 12.8 6.5 0.18 12.1 6.5 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 SDA1 PF05285.12 CCM00077.1 - 0.54 9.6 31.9 0.71 9.2 31.9 1.1 1 0 0 1 1 1 0 SDA1 DUF2796 PF10986.8 CCM00077.1 - 1.4 8.9 10.2 2.1 8.3 10.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) BAR PF03114.18 CCM00078.1 - 0.35 10.5 6.5 0.098 12.3 1.7 2.6 3 0 0 3 3 3 0 BAR domain Sugar_tr PF00083.24 CCM00079.1 - 9.4e-39 133.5 30.1 4.8e-23 81.7 9.0 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCM00079.1 - 1.3e-21 77.0 42.0 9.4e-20 70.8 39.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetate_kinase PF00871.17 CCM00081.1 - 3.1e-86 289.5 0.0 7.5e-84 281.7 0.0 2.3 1 1 0 1 1 1 1 Acetokinase family XFP_N PF09364.10 CCM00082.1 - 6.6e-152 505.5 0.0 8.8e-152 505.1 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.15 CCM00082.1 - 1.9e-76 255.7 0.0 2.8e-76 255.2 0.0 1.2 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.10 CCM00082.1 - 2.6e-76 255.6 0.0 4.1e-76 255.0 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain TPP_enzyme_C PF02775.21 CCM00082.1 - 0.0018 18.0 0.1 0.0061 16.4 0.1 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Abhydrolase_6 PF12697.7 CCM00083.1 - 3.8e-19 70.2 0.1 4.4e-19 70.0 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCM00083.1 - 1e-17 64.6 0.1 1.3e-13 51.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM00083.1 - 1.5e-14 53.9 0.2 1.6e-13 50.5 0.2 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CCM00083.1 - 0.018 15.1 0.2 0.38 10.8 0.0 2.1 2 0 0 2 2 2 0 Thioesterase domain DLH PF01738.18 CCM00083.1 - 0.031 13.8 0.2 0.081 12.5 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CCM00083.1 - 0.09 12.2 0.5 0.49 9.8 0.1 2.1 2 1 0 2 2 2 0 Prolyl oligopeptidase family Na_Ca_ex PF01699.24 CCM00084.1 - 4.7e-40 137.0 47.4 9.7e-26 90.5 15.1 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein p53-inducible11 PF14936.6 CCM00084.1 - 0.014 15.4 1.1 0.029 14.4 0.2 2.0 2 0 0 2 2 2 0 Tumour protein p53-inducible protein 11 p450 PF00067.22 CCM00085.1 - 1.1e-62 212.3 0.0 2.8e-62 211.0 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 GTP_cyclohydroI PF01227.22 CCM00085.1 - 0.045 13.2 0.0 0.094 12.1 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase I RasGAP PF00616.19 CCM00086.1 - 3.6e-36 124.8 0.0 5.1e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP PF00616.19 CCM00087.1 - 4.7e-58 196.3 0.0 3.9e-57 193.3 0.0 2.3 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 CCM00087.1 - 2.2e-36 125.0 1.0 6.5e-36 123.5 0.2 2.2 2 0 0 2 2 2 1 RasGAP C-terminus F-box-like PF12937.7 CCM00088.1 - 3.5e-05 23.6 0.8 3.5e-05 23.6 0.8 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM00088.1 - 0.00011 22.0 0.4 0.00025 20.8 0.4 1.7 1 0 0 1 1 1 1 F-box domain UreE_N PF02814.15 CCM00088.1 - 0.0079 15.8 0.0 0.062 12.9 0.0 2.2 2 0 0 2 2 2 1 UreE urease accessory protein, N-terminal domain MLD PF11647.8 CCM00089.1 - 0.054 13.8 0.1 0.16 12.3 0.1 1.8 1 0 0 1 1 1 0 Membrane Localization Domain DnaJ_C PF01556.18 CCM00090.1 - 2.6e-26 92.5 0.0 4.2e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 CCM00090.1 - 1.1e-13 51.3 14.2 2.5e-13 50.2 14.2 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCM00090.1 - 4.6e-06 26.5 7.0 0.0022 17.9 0.9 2.7 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCM00090.1 - 1.3e-05 25.1 3.3 0.098 12.7 0.6 2.5 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 CCM00090.1 - 0.00075 19.8 9.1 0.18 12.2 1.4 3.1 2 1 1 3 3 3 2 Restriction alleviation protein Lar TF_Zn_Ribbon PF08271.12 CCM00090.1 - 0.22 11.1 0.7 22 4.6 0.0 2.8 2 1 0 2 2 2 0 TFIIB zinc-binding TackOD1 PF18551.1 CCM00090.1 - 0.34 10.5 4.6 0.46 10.1 0.1 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 CCM00090.1 - 2.3 8.3 10.1 12 6.0 10.1 2.0 1 1 0 1 1 1 0 Double zinc ribbon Cullin PF00888.22 CCM00091.1 - 2.7e-201 670.4 0.1 4.2e-201 669.8 0.1 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCM00091.1 - 5.3e-28 96.8 2.0 1.4e-27 95.5 1.1 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain Xpo1 PF08389.12 CCM00091.1 - 4e-17 62.6 0.0 4e-17 62.6 0.0 3.7 5 0 0 5 5 5 1 Exportin 1-like protein Asp PF00026.23 CCM00093.1 - 1e-45 156.5 0.2 1.5e-45 156.0 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM00093.1 - 4.1e-09 36.9 2.9 1.6e-07 31.7 2.9 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal BRO1 PF03097.18 CCM00095.1 - 7.9e-35 120.4 0.0 8.7e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CCM00096.1 - 1.1e-72 244.8 11.6 1.7e-72 244.2 11.6 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF3421 PF11901.8 CCM00097.1 - 4.7e-31 107.1 0.0 6e-31 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3421) WLM PF08325.10 CCM00098.1 - 8.6e-21 74.9 0.0 8.6e-21 74.9 0.0 2.3 2 0 0 2 2 2 1 WLM domain DUF45 PF01863.17 CCM00098.1 - 0.019 15.0 0.1 0.13 12.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF45 PFK PF00365.20 CCM00099.1 - 4.5e-185 613.5 0.4 1.2e-102 343.0 0.6 2.7 2 1 0 2 2 2 2 Phosphofructokinase FAM216B PF15107.6 CCM00099.1 - 0.039 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 FAM216B protein family DAGK_cat PF00781.24 CCM00099.1 - 0.052 13.2 0.2 0.16 11.6 0.2 1.8 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain KilA-N PF04383.13 CCM00100.1 - 0.0056 16.5 0.5 0.27 11.1 0.0 2.6 2 1 0 2 2 2 1 KilA-N domain Hamartin PF04388.12 CCM00100.1 - 3.9 6.0 10.7 5 5.7 10.7 1.1 1 0 0 1 1 1 0 Hamartin protein ketoacyl-synt PF00109.26 CCM00101.1 - 1e-75 254.6 0.0 1.8e-75 253.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCM00101.1 - 5.8e-41 141.0 0.0 1.5e-40 139.7 0.0 1.7 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCM00101.1 - 1.9e-37 127.9 2.6 5.5e-37 126.4 2.6 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 CCM00101.1 - 6.6e-19 68.9 0.2 3.9e-18 66.4 0.0 2.4 2 1 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 CCM00101.1 - 1.2e-18 67.4 0.0 4e-18 65.7 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase PP-binding PF00550.25 CCM00101.1 - 2.8e-18 66.0 1.2 3.8e-08 33.6 0.1 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site SAT PF16073.5 CCM00101.1 - 1.4e-13 51.1 0.3 1e-11 45.1 0.6 3.0 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis KAsynt_C_assoc PF16197.5 CCM00101.1 - 6.8e-10 39.4 0.0 1.7e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCM00101.1 - 3.5e-05 23.3 0.1 8.8e-05 22.0 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Abhydrolase_6 PF12697.7 CCM00101.1 - 7.8e-05 23.4 3.0 0.00017 22.3 0.4 2.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CCM00101.1 - 0.015 15.2 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 CCM00101.1 - 0.059 13.1 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 CCM00101.1 - 0.064 13.0 0.3 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase family Pcc1 PF09341.10 CCM00102.1 - 1.1e-23 83.2 0.9 1.8e-23 82.4 0.9 1.3 1 0 0 1 1 1 1 Transcription factor Pcc1 Peptidase_M24 PF00557.24 CCM00103.1 - 2.7e-16 59.9 0.1 3.5e-16 59.5 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Methyltransf_25 PF13649.6 CCM00104.1 - 1.2e-16 61.2 0.0 3.6e-16 59.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00104.1 - 1.3e-11 45.0 0.0 3.9e-11 43.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM00104.1 - 7.6e-07 29.1 0.0 1.7e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM00104.1 - 9.1e-07 28.8 0.0 1.7e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM00104.1 - 5.6e-06 27.0 0.0 9.8e-05 23.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCM00104.1 - 0.00011 21.8 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 CCM00104.1 - 0.00017 21.0 0.0 0.001 18.5 0.0 1.9 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 CCM00104.1 - 0.00042 19.8 0.0 0.0017 17.9 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 CCM00104.1 - 0.0022 17.4 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 CCM00104.1 - 0.0025 17.2 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 CCM00104.1 - 0.082 13.0 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF5069 PF16798.5 CCM00104.1 - 0.17 12.1 1.1 0.26 11.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5069) NDUF_B8 PF05821.11 CCM00105.1 - 1.2e-06 28.5 0.9 2.4e-06 27.5 0.9 1.6 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) XPG_N PF00752.17 CCM00106.1 - 6.6e-29 100.4 0.0 1.4e-28 99.4 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CCM00106.1 - 1.8e-26 92.3 0.0 4.8e-26 91.0 0.0 1.8 1 0 0 1 1 1 1 XPG I-region PH PF00169.29 CCM00106.1 - 0.0013 19.2 0.0 0.17 12.4 0.0 2.8 2 0 0 2 2 2 1 PH domain Neugrin PF06413.11 CCM00106.1 - 0.033 14.2 1.7 0.19 11.7 1.7 2.4 1 0 0 1 1 1 0 Neugrin WRNPLPNID PF15017.6 CCM00106.1 - 0.72 10.8 6.5 17 6.4 3.0 4.0 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Herpes_UL49_2 PF04823.12 CCM00106.1 - 2.3 8.4 11.6 3 8.0 2.7 3.4 3 0 0 3 3 3 0 Herpesvirus UL49 tegument protein PGA2 PF07543.12 CCM00106.1 - 3.2 7.7 5.3 17 5.4 5.3 2.3 1 0 0 1 1 1 0 Protein trafficking PGA2 ADH_N_2 PF16884.5 CCM00107.1 - 6.2e-30 103.3 0.0 1.1e-29 102.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CCM00107.1 - 2.5e-14 53.4 0.0 4.1e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM00107.1 - 2e-08 35.4 0.0 4e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PhoH PF02562.16 CCM00107.1 - 0.09 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Citrate_synt PF00285.21 CCM00108.1 - 1.7e-27 96.4 0.0 2.4e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Citrate_synt PF00285.21 CCM00109.1 - 5.3e-84 282.3 0.0 6e-84 282.2 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain AAA PF00004.29 CCM00111.1 - 2.4e-40 138.0 0.0 4.4e-40 137.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCM00111.1 - 2.6e-11 43.3 0.0 5.5e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CCM00111.1 - 2.5e-09 36.8 0.6 5.1e-09 35.8 0.6 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 CCM00111.1 - 3.3e-06 27.4 0.6 0.0043 17.3 0.6 2.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 CCM00111.1 - 4.1e-05 22.9 0.0 6.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 CCM00111.1 - 9.1e-05 22.6 0.0 0.00021 21.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CCM00111.1 - 0.00011 22.2 0.4 0.00074 19.5 0.4 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCM00111.1 - 0.00025 21.5 0.2 0.0091 16.4 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CCM00111.1 - 0.00057 19.7 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 CCM00111.1 - 0.0028 17.5 0.0 0.0066 16.3 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CCM00111.1 - 0.006 16.8 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CCM00111.1 - 0.008 15.5 0.5 0.26 10.6 0.1 2.3 1 1 1 2 2 2 1 KaiC Bac_DnaA PF00308.18 CCM00111.1 - 0.0088 15.9 0.2 0.03 14.2 0.2 1.7 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_14 PF13173.6 CCM00111.1 - 0.01 15.8 0.1 0.039 14.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CCM00111.1 - 0.011 16.0 0.4 0.065 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Prot_ATP_OB_N PF17758.1 CCM00111.1 - 0.015 15.0 0.3 0.071 12.8 0.0 2.3 3 0 0 3 3 2 0 Proteasomal ATPase OB N-terminal domain IstB_IS21 PF01695.17 CCM00111.1 - 0.017 14.8 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 CCM00111.1 - 0.018 15.6 0.7 0.029 14.9 0.0 1.7 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 CCM00111.1 - 0.026 14.5 0.2 0.81 9.6 0.1 2.9 2 1 0 3 3 3 0 NACHT domain Sigma54_activat PF00158.26 CCM00111.1 - 0.04 13.6 0.1 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 CCM00111.1 - 0.04 13.6 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TIP49 PF06068.13 CCM00111.1 - 0.077 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 CCM00111.1 - 0.079 13.4 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 CCM00111.1 - 0.11 12.3 0.0 0.3 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CCM00111.1 - 0.11 11.7 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 CCM00111.1 - 0.12 11.7 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CCM00111.1 - 0.14 11.9 0.4 0.42 10.3 0.4 1.9 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CCM00111.1 - 0.15 11.2 0.0 0.61 9.2 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 CCM00111.1 - 0.19 11.3 0.2 0.67 9.4 0.2 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_17 PF13207.6 CCM00111.1 - 0.26 11.7 0.0 0.26 11.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain Yip1 PF04893.17 CCM00112.1 - 4.5e-14 52.5 12.6 6.3e-14 52.1 12.6 1.2 1 0 0 1 1 1 1 Yip1 domain DUF4199 PF13858.6 CCM00112.1 - 6.7 7.1 8.5 0.62 10.4 4.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Phosphonate-bd PF12974.7 CCM00113.1 - 0.00081 19.0 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_3 PF16868.5 CCM00113.1 - 0.0015 18.0 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 CCM00113.1 - 0.0019 17.7 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1 PF09084.11 CCM00113.1 - 0.0028 17.6 0.0 0.0043 17.0 0.0 1.4 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CCM00113.1 - 0.0061 16.3 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 NMT1-like family Med26 PF08711.11 CCM00115.1 - 7.3e-10 38.7 0.0 2.2e-09 37.2 0.0 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Herpes_DNAp_acc PF04929.12 CCM00115.1 - 3 6.7 5.1 5.1 6.0 5.1 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor PCNP PF15473.6 CCM00115.1 - 4.7 7.9 15.7 0.17 12.6 9.4 1.8 2 0 0 2 2 2 0 PEST, proteolytic signal-containing nuclear protein family Fungal_trans PF04082.18 CCM00118.1 - 2.2e-28 99.0 0.0 3.4e-28 98.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM00118.1 - 5.1e-11 42.5 8.7 9e-11 41.7 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 CCM00118.1 - 0.0033 17.6 0.0 0.0098 16.0 0.0 1.8 2 0 0 2 2 2 1 Gal4-like dimerisation domain ABC_membrane PF00664.23 CCM00119.1 - 3.2e-37 128.7 9.4 3.9e-37 128.4 9.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCM00119.1 - 9.1e-34 116.9 0.0 1.5e-32 113.0 0.0 2.3 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 CCM00119.1 - 8e-06 25.5 0.2 0.0029 17.1 0.0 2.7 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCM00119.1 - 0.00094 19.6 0.1 0.0023 18.3 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CCM00119.1 - 0.0016 18.3 0.1 0.21 11.4 0.0 2.4 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 CCM00119.1 - 0.0021 18.5 0.1 0.033 14.6 0.1 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCM00119.1 - 0.0033 17.7 0.1 0.028 14.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 CCM00119.1 - 0.019 15.2 0.9 0.43 10.8 0.3 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 CCM00119.1 - 0.033 14.2 0.0 0.096 12.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CCM00119.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 CCM00119.1 - 0.066 13.3 0.0 0.34 11.0 0.0 2.2 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CCM00119.1 - 0.066 13.0 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain CodY PF06018.14 CCM00119.1 - 0.082 12.4 0.4 6.8 6.2 0.0 2.5 3 0 0 3 3 3 0 CodY GAF-like domain AAA_25 PF13481.6 CCM00119.1 - 0.092 12.3 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCM00119.1 - 0.12 12.2 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 CCM00119.1 - 0.13 11.9 0.0 0.44 10.2 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 CCM00119.1 - 0.16 12.0 0.0 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain CRAL_TRIO_N PF03765.15 CCM00120.1 - 0.055 13.7 0.3 0.093 12.9 0.3 1.3 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain ADH_N PF08240.12 CCM00121.1 - 1.3e-20 73.3 0.7 2.1e-20 72.6 0.7 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM00121.1 - 1.4e-14 54.2 0.1 2.7e-14 53.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCM00121.1 - 0.0042 16.4 0.2 0.0063 15.8 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCM00121.1 - 0.033 13.5 0.0 0.054 12.9 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF374 PF04028.13 CCM00121.1 - 0.037 13.6 0.2 0.083 12.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF374) ELFV_dehydrog PF00208.21 CCM00121.1 - 0.066 12.9 0.1 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_10 PF13460.6 CCM00121.1 - 0.087 12.7 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding MAF_flag10 PF01973.18 CCM00121.1 - 0.24 11.1 0.2 0.69 9.6 0.0 1.9 3 0 0 3 3 3 0 Protein of unknown function DUF115 Aldo_ket_red PF00248.21 CCM00122.1 - 2e-68 230.7 0.0 2.3e-68 230.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 CCM00124.1 - 6.3e-69 232.4 0.0 7.2e-69 232.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family LRR_8 PF13855.6 CCM00125.1 - 2.3e-23 81.7 29.3 1e-10 41.2 1.6 8.0 7 2 2 9 9 9 6 Leucine rich repeat LRR_4 PF12799.7 CCM00125.1 - 4.3e-23 81.0 29.3 4.9e-07 30.0 6.2 8.6 6 3 1 8 8 8 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCM00125.1 - 6.3e-12 44.5 26.8 0.31 11.2 0.3 9.9 10 0 0 10 10 10 5 Leucine Rich repeat LRR_1 PF00560.33 CCM00125.1 - 2.8e-11 42.3 28.8 1.3 9.9 0.2 10.7 11 0 0 11 11 11 5 Leucine Rich Repeat LRR_5 PF13306.6 CCM00125.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) S10_plectin PF03501.15 CCM00126.1 - 3.1e-43 145.8 0.2 3.7e-43 145.5 0.2 1.1 1 0 0 1 1 1 1 Plectin/S10 domain TrmB PF01978.19 CCM00126.1 - 0.028 14.3 0.0 0.044 13.7 0.0 1.4 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB O-FucT PF10250.9 CCM00127.1 - 0.00019 21.3 0.0 0.0003 20.6 0.0 1.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF3959 PF13105.6 CCM00127.1 - 0.095 12.2 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) F-box-like PF12937.7 CCM00128.1 - 8.3e-05 22.4 0.9 0.00025 20.9 0.5 2.1 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 CCM00128.1 - 1.3 9.6 3.6 96 3.6 0.1 4.2 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) p450 PF00067.22 CCM00130.1 - 9.4e-09 34.5 0.0 9.4e-09 34.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lipase_GDSL_2 PF13472.6 CCM00131.1 - 4.6e-13 50.0 1.5 1.3e-12 48.5 1.5 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCM00131.1 - 1e-07 32.1 0.1 7.5e-07 29.3 0.1 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF3552 PF12072.8 CCM00133.1 - 0.0019 17.7 4.6 0.005 16.3 2.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) Lzipper-MIP1 PF14389.6 CCM00133.1 - 0.59 10.5 5.9 0.67 10.3 0.0 3.3 3 1 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 DUF3915 PF13054.6 CCM00133.1 - 6.6 6.7 5.4 10 6.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DUF2418 PF10332.9 CCM00134.1 - 1.2e-30 105.9 0.1 2.6e-30 104.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) zf-H2C2_2 PF13465.6 CCM00135.1 - 2.3e-21 75.2 21.4 6.4e-07 29.5 0.0 5.4 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 CCM00135.1 - 1.6e-18 66.0 24.4 6.6e-06 26.3 1.5 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM00135.1 - 2.4e-10 40.3 22.2 0.017 15.9 0.4 4.9 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCM00135.1 - 7.1e-09 35.7 0.0 0.63 10.4 0.0 4.5 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM00135.1 - 4.2e-07 30.1 4.0 0.094 13.1 0.2 4.3 4 0 0 4 4 4 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 CCM00135.1 - 0.013 16.1 2.8 6.7 7.4 0.0 4.1 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 CCM00135.1 - 0.26 11.3 8.0 0.87 9.7 0.0 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-TRAF PF02176.18 CCM00135.1 - 0.75 10.5 7.8 0.53 11.0 1.2 2.9 2 1 1 3 3 3 0 TRAF-type zinc finger zf_ZIC PF18366.1 CCM00135.1 - 7.5 6.7 7.6 47 4.2 0.2 4.2 5 0 0 5 5 5 0 Zic proteins zinc finger domain RTA1 PF04479.13 CCM00136.1 - 7.2e-40 136.8 2.9 8.8e-40 136.5 2.9 1.0 1 0 0 1 1 1 1 RTA1 like protein FAM110_C PF14160.6 CCM00137.1 - 0.11 13.6 0.1 0.16 13.0 0.1 1.2 1 0 0 1 1 1 0 Centrosome-associated C terminus PI31_Prot_N PF11566.8 CCM00138.1 - 0.034 13.9 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal Polyoma_coat2 PF00761.20 CCM00138.1 - 0.56 9.9 4.1 0.81 9.4 4.1 1.2 1 0 0 1 1 1 0 Polyomavirus coat protein p450 PF00067.22 CCM00139.1 - 3.8e-75 253.4 0.0 4.5e-75 253.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Herpes_UL21 PF03252.13 CCM00139.1 - 0.01 14.6 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL21 adh_short_C2 PF13561.6 CCM00140.1 - 3.9e-37 128.1 0.0 1.1e-36 126.5 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM00140.1 - 1.7e-35 122.3 0.0 2.2e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM00140.1 - 2.2e-05 24.5 0.1 6.6e-05 22.9 0.1 1.7 1 1 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 CCM00140.1 - 0.0048 16.3 0.2 0.012 15.0 0.2 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 CCM00140.1 - 0.0073 15.8 0.0 0.024 14.1 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM00140.1 - 0.22 10.9 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Cnn_1N PF07989.11 CCM00141.1 - 2.4e-23 82.1 10.0 2.4e-23 82.1 10.0 12.0 7 4 6 13 13 13 4 Centrosomin N-terminal motif 1 Mto2_bdg PF12808.7 CCM00141.1 - 0.0035 17.6 10.4 0.0035 17.6 10.4 10.8 9 2 0 10 10 10 1 Micro-tubular organiser Mto1 C-term Mto2-binding region ZapB PF06005.12 CCM00141.1 - 0.0062 17.0 6.7 0.0062 17.0 6.7 14.1 5 5 7 12 12 12 4 Cell division protein ZapB HIP1_clath_bdg PF16515.5 CCM00141.1 - 0.019 15.6 1.5 0.019 15.6 1.5 12.4 3 2 11 14 14 14 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4250 PF14056.6 CCM00141.1 - 0.9 9.5 11.6 2.5 8.1 1.3 4.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4250) DUF92 PF01940.16 CCM00142.1 - 1.2e-74 250.7 6.4 1.4e-74 250.5 6.4 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 C2 PF00168.30 CCM00144.1 - 3.9e-13 49.6 0.0 6.6e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 C2 domain F-box PF00646.33 CCM00146.1 - 6.2e-05 22.8 0.2 0.00016 21.5 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCM00146.1 - 8.8e-05 22.3 0.5 0.00021 21.1 0.5 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCM00146.1 - 0.013 15.9 1.3 3.3 8.3 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) PNK3P PF08645.11 CCM00147.1 - 6.3e-43 146.3 0.0 1.1e-42 145.6 0.0 1.4 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CCM00147.1 - 5.9e-19 68.6 0.1 4e-16 59.5 0.1 2.5 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CCM00147.1 - 0.0063 15.8 0.0 1.6 7.9 0.0 2.5 2 1 1 3 3 3 2 Zeta toxin MMR_HSR1 PF01926.23 CCM00147.1 - 0.026 14.6 0.0 0.065 13.3 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase KTI12 PF08433.10 CCM00147.1 - 0.039 13.4 1.4 3.1 7.2 1.4 2.2 1 1 0 1 1 1 0 Chromatin associated protein KTI12 Sel1 PF08238.12 CCM00148.1 - 5.2e-49 163.6 25.0 4e-10 40.0 0.0 7.4 7 0 0 7 7 7 7 Sel1 repeat PITH PF06201.13 CCM00148.1 - 7.1e-38 130.2 1.1 1.3e-37 129.4 1.1 1.4 1 0 0 1 1 1 1 PITH domain JHD PF17811.1 CCM00150.1 - 1.6e-10 41.4 0.0 3.1e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Jumonji helical domain JmjC PF02373.22 CCM00150.1 - 1.1e-07 32.2 1.5 1.3e-06 28.8 1.5 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 CCM00150.1 - 0.00033 20.5 2.0 0.00069 19.5 2.0 1.5 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.6 CCM00150.1 - 0.0073 16.1 1.0 0.057 13.1 1.0 2.3 1 1 0 1 1 1 1 Cupin-like domain zf-RING_9 PF13901.6 CCM00150.1 - 0.052 13.5 0.9 0.98 9.4 0.3 2.2 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Prok-RING_1 PF14446.6 CCM00150.1 - 0.057 13.4 2.2 0.11 12.4 2.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 SRP72 PF08492.12 CCM00150.1 - 0.35 11.3 0.0 0.35 11.3 0.0 2.5 3 0 0 3 3 3 0 SRP72 RNA-binding domain PGK PF00162.19 CCM00151.1 - 3e-144 480.7 0.2 3.3e-144 480.5 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Peripla_BP_4 PF13407.6 CCM00151.1 - 0.011 15.3 0.9 0.018 14.6 0.4 1.6 2 0 0 2 2 2 0 Periplasmic binding protein domain DUF4061 PF13270.6 CCM00152.1 - 0.32 11.3 10.1 1 9.7 10.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) Jnk-SapK_ap_N PF09744.9 CCM00152.1 - 1 9.6 13.1 1.5 9.0 13.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 V_ATPase_I PF01496.19 CCM00152.1 - 4.2 5.2 6.2 4.8 5.0 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PH PF00169.29 CCM00153.1 - 9.3e-07 29.3 0.0 2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 PH domain LCAT PF02450.15 CCM00154.1 - 1.6e-60 205.3 0.1 1e-59 202.7 0.1 1.9 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 CCM00154.1 - 0.0016 19.1 0.2 0.013 16.1 0.0 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF900 PF05990.12 CCM00154.1 - 0.014 14.9 0.1 0.031 13.8 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 CCM00154.1 - 0.21 11.1 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Trp_halogenase PF04820.14 CCM00155.1 - 3.4e-27 95.4 0.6 1.2e-11 44.1 0.2 3.7 2 2 1 3 3 3 2 Tryptophan halogenase FAD_binding_3 PF01494.19 CCM00155.1 - 1.8e-09 37.3 0.0 1.6e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCM00155.1 - 2.9e-06 27.4 0.2 1.7e-05 24.9 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM00155.1 - 0.00049 19.8 0.3 0.12 11.9 0.1 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM00155.1 - 0.00052 19.3 0.1 0.0011 18.3 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCM00155.1 - 0.0021 17.5 0.2 0.0034 16.8 0.2 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCM00155.1 - 0.0028 16.4 0.1 0.0061 15.3 0.1 1.5 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 CCM00155.1 - 0.0033 16.6 0.0 0.0058 15.8 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CCM00155.1 - 0.0053 15.9 0.3 0.016 14.3 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain NA37 PF04245.13 CCM00156.1 - 0.1 12.1 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein DUF2408 PF10303.9 CCM00157.1 - 0.0032 18.0 0.4 0.37 11.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2408) PIN_12 PF16289.5 CCM00157.1 - 0.22 12.0 0.7 0.46 11.0 0.7 1.6 1 1 0 1 1 1 0 PIN domain NAD_kinase PF01513.21 CCM00160.1 - 2.5e-61 207.4 0.0 3.3e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 CCM00160.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF3649 PF12365.8 CCM00161.1 - 3.2 7.5 7.2 7.4 6.4 7.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3649) MFS_1 PF07690.16 CCM00162.1 - 2.4e-39 135.3 12.2 5.7e-22 78.1 9.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM00162.1 - 1.7e-11 43.7 4.1 1.4e-10 40.6 0.9 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 CCM00162.1 - 0.002 17.1 6.0 0.27 10.0 0.2 2.5 3 0 0 3 3 3 2 MFS_1 like family MFS_3 PF05977.13 CCM00162.1 - 0.91 7.8 11.6 3.1 6.1 0.2 2.6 3 0 0 3 3 3 0 Transmembrane secretion effector XPG_I_2 PF12813.7 CCM00163.1 - 4.7e-07 29.5 0.5 0.0078 15.7 0.0 4.6 4 1 0 4 4 4 2 XPG domain containing ToxS PF17323.2 CCM00163.1 - 0.067 12.9 0.3 0.14 11.8 0.3 1.4 1 0 0 1 1 1 0 Trans-membrane regulatory protein ToxS Methyltransf_12 PF08242.12 CCM00165.1 - 1e-07 32.6 0.0 1.6e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM00165.1 - 8.4e-07 29.0 0.0 1.1e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00165.1 - 1e-06 29.3 0.0 1.9e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM00165.1 - 1.1e-06 28.5 0.0 1.3e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM00165.1 - 1.5e-06 28.8 0.0 2.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCM00165.1 - 0.00012 21.7 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CCM00165.1 - 0.02 14.3 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CCM00165.1 - 0.053 13.3 0.0 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 CCM00165.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain AMP-binding PF00501.28 CCM00166.1 - 2.4e-63 214.2 0.0 3e-63 213.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF1456 PF07308.13 CCM00166.1 - 0.19 12.1 0.0 0.45 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) ketoacyl-synt PF00109.26 CCM00168.1 - 7.5e-53 179.7 0.0 1.5e-52 178.7 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CCM00168.1 - 1.7e-34 119.3 0.1 2.2e-29 102.6 0.0 2.5 2 0 0 2 2 2 2 KR domain Acyl_transf_1 PF00698.21 CCM00168.1 - 3.8e-27 95.6 0.1 1.1e-26 94.1 0.1 1.8 2 0 0 2 2 2 1 Acyl transferase domain NAD_binding_4 PF07993.12 CCM00168.1 - 9.9e-27 93.7 0.1 8.2e-26 90.7 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 CCM00168.1 - 3e-26 91.7 0.0 1.4e-25 89.6 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCM00168.1 - 3e-17 62.8 0.0 1.1e-16 60.9 0.0 1.9 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCM00168.1 - 1.4e-12 48.1 0.0 6.9e-12 45.8 0.0 2.1 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 CCM00168.1 - 4.8e-08 32.8 0.0 1e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM00168.1 - 6.6e-07 29.6 0.7 1.4e-06 28.5 0.7 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CCM00168.1 - 0.0018 17.8 0.3 2.6 7.5 0.0 4.0 4 1 0 4 4 4 1 short chain dehydrogenase Thiolase_N PF00108.23 CCM00168.1 - 0.0033 16.8 0.1 0.0062 15.9 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 CCM00168.1 - 0.016 14.4 0.1 0.049 12.8 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein ACP_syn_III PF08545.10 CCM00168.1 - 0.025 14.4 0.0 0.078 12.8 0.0 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Pyr_redox_2 PF07992.14 CCM00170.1 - 1.9e-08 33.9 0.0 7.5e-05 22.1 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM00170.1 - 7.6e-08 32.5 0.4 8.2e-06 26.0 0.0 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM00170.1 - 3.1e-07 30.3 0.2 0.00033 20.4 0.1 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCM00170.1 - 1.8e-06 27.5 0.2 3.6e-05 23.2 0.2 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM00170.1 - 1.9e-06 27.2 0.3 0.0091 15.2 1.0 3.4 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 CCM00170.1 - 0.00042 18.9 0.0 0.025 13.0 0.0 2.6 2 1 1 3 3 3 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 CCM00170.1 - 0.00043 20.3 0.0 0.0074 16.3 0.0 2.4 1 1 0 1 1 1 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CCM00170.1 - 0.00077 18.9 0.0 0.37 10.0 0.0 2.7 2 1 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 CCM00170.1 - 0.00097 19.6 0.0 0.099 13.2 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM00170.1 - 0.0014 17.9 0.1 0.004 16.4 0.0 1.7 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 CCM00170.1 - 0.0028 17.0 0.0 0.013 14.7 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.6 CCM00170.1 - 0.015 15.7 0.0 5.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 CCM00170.1 - 0.028 14.5 0.0 10 6.2 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 CCM00170.1 - 0.045 13.4 0.6 2.1 8.0 0.0 2.6 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 CCM00170.1 - 0.11 11.6 0.1 2.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 CCM00170.1 - 0.13 11.3 0.4 1.6 7.7 0.0 2.1 2 1 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCM00170.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CCM00170.1 - 0.16 10.6 0.0 0.28 9.8 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Glu_dehyd_C PF16912.5 CCM00170.1 - 0.17 11.4 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus MCRA PF06100.11 CCM00170.1 - 0.21 10.3 0.0 6.6 5.4 0.0 2.1 2 0 0 2 2 2 0 MCRA family FH2 PF02181.23 CCM00171.1 - 1.6e-72 244.7 0.2 1.9e-72 244.4 0.2 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain IU_nuc_hydro PF01156.19 CCM00172.1 - 1e-86 291.3 0.0 1.2e-86 291.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase ClpS PF02617.17 CCM00172.1 - 0.15 11.9 0.1 18 5.2 0.0 2.3 2 0 0 2 2 2 0 ATP-dependent Clp protease adaptor protein ClpS RRN3 PF05327.11 CCM00173.1 - 1.3e-198 661.1 0.0 1.3e-198 661.1 0.0 2.0 1 1 1 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 GOLD_2 PF13897.6 CCM00173.1 - 0.11 13.0 1.1 0.24 11.9 1.1 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF4484 PF14831.6 CCM00173.1 - 5.5 7.0 14.1 14 5.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) LNS2 PF08235.13 CCM00174.1 - 3.3e-101 337.5 0.0 4.6e-101 337.0 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 CCM00174.1 - 1.6e-34 117.9 0.0 4.6e-34 116.4 0.0 1.8 1 1 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 CCM00174.1 - 5.5e-07 29.7 0.0 1.4e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Acid_phosphat_B PF03767.14 CCM00174.1 - 0.17 11.4 0.1 0.58 9.7 0.0 1.9 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Complex1_LYR PF05347.15 CCM00175.1 - 2.3e-09 37.2 0.5 3.8e-09 36.5 0.5 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) tRNA-synt_1 PF00133.22 CCM00175.1 - 0.023 13.0 0.0 0.026 12.8 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) MFS_1 PF07690.16 CCM00176.1 - 5.2e-22 78.3 56.5 2.7e-18 66.0 39.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TMIE PF16038.5 CCM00176.1 - 0.25 11.2 0.1 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 TMIE protein WD40 PF00400.32 CCM00177.1 - 2.1e-10 41.0 9.6 0.079 13.9 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00177.1 - 8e-10 38.9 0.0 0.00084 19.6 0.0 5.0 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCM00177.1 - 1.6e-05 24.7 0.5 0.037 14.0 0.0 4.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCM00177.1 - 0.012 14.2 0.0 0.13 10.8 0.0 2.0 1 1 0 2 2 2 0 Cytochrome D1 heme domain Sigma54_AID PF00309.20 CCM00177.1 - 0.041 13.8 0.3 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) Coatomer_WDAD PF04053.14 CCM00177.1 - 0.085 11.9 0.0 4.6 6.2 0.0 2.2 2 0 0 2 2 2 0 Coatomer WD associated region IKI3 PF04762.12 CCM00177.1 - 0.14 10.2 0.0 3.9 5.3 0.0 2.5 2 1 1 3 3 3 0 IKI3 family Cadherin_C_2 PF16492.5 CCM00178.1 - 4 8.2 4.7 25 5.7 0.5 3.4 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal adh_short PF00106.25 CCM00179.1 - 1.6e-21 76.7 0.1 3.8e-21 75.5 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00179.1 - 2.1e-11 43.8 0.0 8e-11 41.9 0.0 1.9 1 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Btz PF09405.10 CCM00179.1 - 8.1e-10 39.1 2.0 8.1e-10 39.1 2.0 2.4 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding KR PF08659.10 CCM00179.1 - 4.3e-05 23.5 0.1 6.9e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 KR domain Astro_capsid_p PF12226.8 CCM00179.1 - 0.019 14.1 0.5 0.033 13.4 0.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DLIC PF05783.11 CCM00180.1 - 8.1e-37 127.1 4.5 2.3e-29 102.6 0.0 4.1 2 2 1 3 3 3 2 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 CCM00180.1 - 0.00098 19.5 0.0 0.0027 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 CCM00180.1 - 0.0017 17.9 0.0 0.057 12.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCM00180.1 - 0.0055 16.8 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase KTI12 PF08433.10 CCM00180.1 - 0.025 14.0 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Roc PF08477.13 CCM00180.1 - 0.036 14.3 0.0 0.084 13.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CCM00180.1 - 0.04 14.0 0.1 0.073 13.1 0.1 1.4 1 0 0 1 1 1 0 Dynamin family ATP_bind_1 PF03029.17 CCM00180.1 - 0.044 13.5 0.0 1.3 8.7 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CCM00180.1 - 0.052 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 CCM00180.1 - 0.062 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 CCM00180.1 - 0.076 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCM00180.1 - 0.082 12.7 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 CCM00180.1 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 CCM00180.1 - 0.16 11.7 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCM00180.1 - 0.18 11.7 0.0 3.7 7.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 CCM00180.1 - 0.18 11.1 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family TIP41 PF04176.13 CCM00181.1 - 9e-64 214.1 0.0 1.1e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 TIP41-like family CMAS PF02353.20 CCM00182.1 - 1.9e-53 181.5 0.0 2.5e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CCM00182.1 - 3.7e-07 30.8 0.0 8e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00182.1 - 9.5e-06 26.2 0.0 2.3e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM00182.1 - 7.6e-05 22.6 0.0 0.00019 21.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM00182.1 - 0.0038 18.0 0.0 0.0081 16.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 CCM00182.1 - 0.0038 16.8 0.0 0.014 14.9 0.0 1.8 2 0 0 2 2 2 1 Histone methylation protein DOT1 Methyltransf_24 PF13578.6 CCM00182.1 - 0.028 15.4 0.2 0.13 13.3 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 CCM00182.1 - 0.029 13.9 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 CCM00182.1 - 0.042 13.2 0.0 0.06 12.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) GCD14 PF08704.10 CCM00182.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Abhydrolase_1 PF00561.20 CCM00183.1 - 7.2e-22 78.3 0.3 1.1e-20 74.4 0.1 2.3 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCM00183.1 - 9.9e-18 64.2 0.0 1.7e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 CCM00183.1 - 0.0018 17.6 0.0 1.8 7.7 0.0 3.3 3 0 0 3 3 3 2 Serine aminopeptidase, S33 FA_hydroxylase PF04116.13 CCM00186.1 - 8.5e-24 84.4 19.2 8.5e-24 84.4 19.2 1.8 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Lipase_chap PF03280.14 CCM00186.1 - 0.043 13.8 0.1 0.062 13.3 0.1 1.1 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein Questin_oxidase PF14027.6 CCM00189.1 - 8e-91 305.1 0.0 9.3e-91 304.9 0.0 1.0 1 0 0 1 1 1 1 Questin oxidase-like Questin_oxidase PF14027.6 CCM00192.1 - 2.3e-101 339.7 0.0 2.7e-101 339.5 0.0 1.0 1 0 0 1 1 1 1 Questin oxidase-like F-box-like PF12937.7 CCM00193.1 - 5.5e-08 32.6 1.3 2.1e-07 30.7 0.5 2.4 2 0 0 2 2 2 1 F-box-like Cys_Met_Meta_PP PF01053.20 CCM00194.1 - 3e-145 483.6 0.0 3.4e-145 483.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CCM00194.1 - 2.5e-13 50.1 0.2 1.8e-11 44.0 0.2 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CCM00194.1 - 1.6e-10 40.7 0.1 3.2e-10 39.7 0.1 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CCM00194.1 - 5.9e-08 32.0 0.7 9.9e-08 31.3 0.2 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCM00194.1 - 0.00011 21.6 0.0 0.00023 20.5 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 CCM00194.1 - 0.0011 17.9 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.11 CCM00194.1 - 0.019 13.5 0.0 0.025 13.1 0.0 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase SepSecS PF05889.13 CCM00194.1 - 0.044 12.5 0.0 0.066 11.9 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Asparaginase_C PF17763.1 CCM00194.1 - 0.16 12.2 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain BRK PF07533.16 CCM00194.1 - 0.5 10.0 2.2 1.7 8.4 0.3 2.4 2 0 0 2 2 2 0 BRK domain F-box-like PF12937.7 CCM00195.1 - 0.00021 21.1 2.1 0.00082 19.2 1.9 2.2 2 0 0 2 2 2 1 F-box-like Peptidase_S9 PF00326.21 CCM00196.1 - 1.2e-40 139.3 0.0 2e-40 138.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 CCM00196.1 - 5.9e-06 26.0 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CCM00196.1 - 6.9e-06 25.5 0.0 0.00016 21.0 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCM00196.1 - 2.2e-05 24.3 0.1 0.092 12.4 0.0 2.6 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CCM00196.1 - 3.9e-05 23.6 0.0 0.00016 21.6 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCM00196.1 - 4.7e-05 23.4 0.0 0.00036 20.6 0.0 2.4 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_2 PF02230.16 CCM00196.1 - 0.0039 17.0 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 CCM00196.1 - 0.016 14.9 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Esterase PF00756.20 CCM00196.1 - 0.034 13.8 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative esterase PD40 PF07676.12 CCM00196.1 - 0.036 14.0 5.4 0.087 12.8 0.4 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PhyH PF05721.13 CCM00198.1 - 3.5e-10 40.5 0.1 5.1e-10 40.0 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) SfsA PF03749.13 CCM00198.1 - 0.0059 16.5 0.0 2.5 8.0 0.0 2.3 2 0 0 2 2 2 2 Sugar fermentation stimulation protein RE domain SAP PF02037.27 CCM00199.1 - 0.017 14.8 0.0 0.038 13.7 0.0 1.6 1 1 0 1 1 1 0 SAP domain Prenylcys_lyase PF07156.14 CCM00199.1 - 0.16 11.0 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Prenylcysteine lyase Acyltransferase PF01553.21 CCM00200.1 - 2.6e-19 69.2 0.0 4.2e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Peptidase_M36 PF02128.15 CCM00201.1 - 5.8e-157 522.6 0.6 7.7e-157 522.2 0.6 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 CCM00201.1 - 1.3e-14 53.8 3.3 2.4e-14 52.9 3.3 1.5 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif ABC_membrane PF00664.23 CCM00202.1 - 3.6e-54 184.3 31.9 1.8e-30 106.5 13.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCM00202.1 - 9.1e-51 172.0 0.0 4.1e-28 98.6 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCM00202.1 - 3.6e-10 39.6 2.1 0.0085 15.6 0.1 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CCM00202.1 - 7.4e-08 32.5 0.3 0.0084 16.2 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 CCM00202.1 - 2.4e-07 31.3 0.1 0.016 15.6 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CCM00202.1 - 2.6e-07 30.3 0.4 0.034 13.9 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 CCM00202.1 - 1.8e-06 28.1 0.2 0.0045 17.1 0.0 2.5 2 0 0 2 2 2 2 Dynamin family Zeta_toxin PF06414.12 CCM00202.1 - 3.2e-06 26.6 0.3 0.056 12.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin RsgA_GTPase PF03193.16 CCM00202.1 - 2.4e-05 24.3 0.3 0.057 13.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CCM00202.1 - 3.1e-05 24.6 0.8 0.13 12.8 0.2 2.9 3 0 0 3 3 2 2 AAA domain DUF815 PF05673.13 CCM00202.1 - 0.00011 21.5 0.3 0.068 12.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_21 PF13304.6 CCM00202.1 - 0.00014 21.8 0.2 0.022 14.6 0.3 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system TrwB_AAD_bind PF10412.9 CCM00202.1 - 0.00047 19.2 1.5 0.087 11.7 0.1 2.2 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 CCM00202.1 - 0.00076 18.9 0.9 0.3 10.4 0.1 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family cobW PF02492.19 CCM00202.1 - 0.0026 17.3 0.6 0.31 10.6 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 CCM00202.1 - 0.0028 17.8 2.6 0.89 9.6 0.1 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_22 PF13401.6 CCM00202.1 - 0.0039 17.5 0.2 6.9 6.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 CCM00202.1 - 0.0041 17.3 0.3 4.6 7.5 0.1 3.0 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 CCM00202.1 - 0.009 15.0 0.7 2.5 7.0 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CCM00202.1 - 0.01 15.8 0.2 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 NACHT domain ATP-synt_ab PF00006.25 CCM00202.1 - 0.011 15.4 0.1 1.2 8.7 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_30 PF13604.6 CCM00202.1 - 0.014 15.2 1.0 3.4 7.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.6 CCM00202.1 - 0.016 15.7 0.3 6.2 7.4 0.1 2.7 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 CCM00202.1 - 0.024 14.5 0.4 5.4 6.9 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B T2SSE PF00437.20 CCM00202.1 - 0.027 13.5 0.1 5.3 6.0 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein KAP_NTPase PF07693.14 CCM00202.1 - 0.027 13.7 0.0 3.1 7.0 0.0 2.4 2 0 0 2 2 2 0 KAP family P-loop domain AAA_7 PF12775.7 CCM00202.1 - 0.043 13.3 0.1 11 5.5 0.0 2.7 2 0 0 2 2 2 0 P-loop containing dynein motor region SbcCD_C PF13558.6 CCM00202.1 - 0.059 13.6 0.3 7.7 6.8 0.0 3.4 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 CCM00202.1 - 0.06 13.0 0.1 9.3 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 CCM00202.1 - 0.069 13.5 0.0 27 5.2 0.0 3.4 3 0 0 3 3 3 0 RNA helicase AAA PF00004.29 CCM00202.1 - 0.099 13.1 0.0 35 4.8 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 CCM00202.1 - 0.11 12.3 0.0 22 4.7 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein TsaE PF02367.17 CCM00202.1 - 0.11 12.4 0.6 9.9 6.2 0.0 2.7 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Glyco_hydro_88 PF07470.13 CCM00203.1 - 3.3e-19 69.2 1.5 4.7e-19 68.7 1.5 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Abhydrolase_3 PF07859.13 CCM00204.1 - 3.5e-11 43.4 0.5 4.9e-11 42.9 0.5 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCM00204.1 - 1.4e-06 27.5 0.6 2.2e-05 23.5 0.6 2.0 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 CCM00204.1 - 0.00016 20.7 0.0 0.00019 20.4 0.0 1.0 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 CCM00204.1 - 0.00023 21.8 5.0 0.00032 21.4 5.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM00204.1 - 0.045 13.0 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF900 PF05990.12 CCM00204.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) CRAL_TRIO PF00650.20 CCM00205.1 - 9.1e-30 103.5 0.1 1.2e-29 103.1 0.1 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCM00205.1 - 9.7e-07 28.9 0.9 3.5e-06 27.1 0.1 2.3 2 1 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CCM00205.1 - 0.067 13.3 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain F-box-like PF12937.7 CCM00206.1 - 0.004 17.0 0.0 0.01 15.7 0.0 1.8 1 0 0 1 1 1 1 F-box-like Cwf_Cwc_15 PF04889.12 CCM00206.1 - 6.9 6.3 14.8 7.6 6.2 5.1 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF262 PF03235.14 CCM00207.1 - 1.2e-14 55.1 0.3 4.8e-14 53.1 0.3 1.8 1 1 0 1 1 1 1 Protein of unknown function DUF262 DUF5578 PF17741.1 CCM00207.1 - 0.29 10.5 1.3 0.44 9.9 1.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5578) MAD PF05557.13 CCM00208.1 - 9.7e-55 186.2 54.6 1.2e-54 185.8 54.6 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein TMF_TATA_bd PF12325.8 CCM00208.1 - 0.0012 19.0 9.6 0.0012 19.0 9.6 7.2 3 3 2 7 7 7 2 TATA element modulatory factor 1 TATA binding DUF4164 PF13747.6 CCM00208.1 - 0.015 15.6 2.5 0.015 15.6 2.5 7.3 5 3 2 7 7 7 0 Domain of unknown function (DUF4164) NPV_P10 PF05531.12 CCM00208.1 - 1.2 9.7 18.4 52 4.4 0.0 6.6 5 2 0 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF4994 PF16385.5 CCM00208.1 - 3.1 7.8 6.7 4.5 7.3 1.1 3.3 3 0 0 3 3 3 0 Domain of unknown function Fez1 PF06818.15 CCM00208.1 - 4.3 7.7 76.4 2.2 8.7 14.3 5.1 2 2 3 5 5 5 0 Fez1 SEP PF08059.13 CCM00209.1 - 1e-24 86.9 0.0 2.9e-24 85.4 0.0 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 CCM00209.1 - 1.4e-14 54.0 0.0 2.2e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 UBX domain MAGE PF01454.19 CCM00210.1 - 6e-52 176.4 0.0 8.7e-52 175.9 0.0 1.3 1 0 0 1 1 1 1 MAGE family FAM176 PF14851.6 CCM00210.1 - 5.4 6.7 6.7 3.2 7.4 3.8 2.1 2 0 0 2 2 2 0 FAM176 family Tubulin PF00091.25 CCM00211.1 - 1.1e-67 228.1 0.0 2.3e-67 227.0 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCM00211.1 - 1.4e-42 144.8 0.1 2.2e-42 144.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CCM00211.1 - 1.8e-06 28.3 0.0 4.8e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 CCM00211.1 - 0.00059 19.1 0.0 0.0047 16.2 0.0 2.0 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 CCM00211.1 - 0.015 15.0 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 Tubulin domain EamA PF00892.20 CCM00212.1 - 5.7e-27 94.5 25.0 1.2e-15 57.9 4.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family E1-N PF14463.6 CCM00212.1 - 0.057 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 E1 N-terminal domain Phage_holin_3_3 PF16083.5 CCM00212.1 - 0.9 9.7 14.3 1.6 8.9 0.3 4.3 3 1 1 4 4 4 0 LydA holin phage, holin superfamily III zf-C2H2 PF00096.26 CCM00213.1 - 0.026 15.0 12.4 0.037 14.5 0.8 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 CCM00213.1 - 0.054 13.6 8.3 0.68 10.0 0.5 2.7 3 0 0 3 3 3 0 Aberrant zinc-finger zf-HYPF PF07503.12 CCM00213.1 - 0.45 10.3 3.1 1.8 8.4 0.5 2.6 2 0 0 2 2 2 0 HypF finger zf-C2H2_4 PF13894.6 CCM00213.1 - 5.6 8.1 13.7 3.5 8.7 0.5 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger TAFII28 PF04719.14 CCM00214.1 - 2.3e-34 117.4 0.4 3.2e-34 116.9 0.4 1.2 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CBFD_NFYB_HMF PF00808.23 CCM00214.1 - 0.00018 21.7 0.1 0.00027 21.1 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-X PF09415.10 CCM00214.1 - 0.09 13.1 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X zf-C2H2 PF00096.26 CCM00215.1 - 1.1e-08 35.1 3.7 0.00013 22.2 0.2 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CCM00215.1 - 0.00035 20.5 0.0 0.037 14.0 0.0 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger FOXP-CC PF16159.5 CCM00215.1 - 0.00044 20.8 2.8 0.0036 17.9 3.1 2.2 1 1 0 1 1 1 1 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CCM00215.1 - 0.0013 19.4 2.7 0.11 13.4 0.1 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 CCM00215.1 - 0.13 12.7 1.0 3.3 8.2 0.0 2.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCM00215.1 - 0.47 10.8 3.4 18 5.7 0.1 3.0 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf_ZIC PF18366.1 CCM00215.1 - 0.56 10.4 3.6 17 5.6 2.1 2.9 1 1 1 2 2 2 0 Zic proteins zinc finger domain Methyltransf_23 PF13489.6 CCM00217.1 - 3.8e-12 46.4 0.0 4.7e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00217.1 - 3.6e-07 30.7 0.0 7.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM00217.1 - 8.1e-06 26.5 0.0 1.4e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM00217.1 - 0.0002 22.1 0.0 0.00033 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM00217.1 - 0.00064 19.5 0.0 0.0012 18.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM00218.1 - 4.5e-11 42.9 0.0 5.8e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00218.1 - 1.5e-07 31.9 0.0 2.9e-07 31.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM00218.1 - 2e-05 25.2 0.0 3.5e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM00218.1 - 0.00018 22.2 0.0 0.00029 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM00218.1 - 0.0011 18.8 0.0 0.0015 18.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CCM00218.1 - 0.012 14.6 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) RrnaAD PF00398.20 CCM00218.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Ras PF00071.22 CCM00219.1 - 3.6e-56 189.2 0.0 4.2e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM00219.1 - 6.4e-33 113.5 0.0 1.1e-32 112.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM00219.1 - 3e-15 56.1 0.0 4e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM00219.1 - 1.4e-06 27.8 0.0 1.7e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM00219.1 - 2.4e-06 27.6 0.0 4.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCM00219.1 - 0.00029 20.4 0.0 0.00069 19.2 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCM00219.1 - 0.0088 16.4 0.0 0.016 15.6 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 CCM00219.1 - 0.023 13.9 1.5 0.54 9.4 0.3 2.1 1 1 1 2 2 2 0 G-protein alpha subunit SRPRB PF09439.10 CCM00219.1 - 0.027 13.9 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 CCM00219.1 - 0.033 13.5 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 CCM00219.1 - 0.054 13.4 0.1 0.42 10.5 0.1 2.0 1 1 0 2 2 2 0 RsgA GTPase TniB PF05621.11 CCM00219.1 - 0.062 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 CCM00219.1 - 0.17 11.7 0.1 0.39 10.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PAP2_3 PF14378.6 CCM00220.1 - 6.3e-26 91.2 15.6 6.3e-26 91.2 15.6 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 CCM00220.1 - 2.8e-08 33.6 6.6 2.8e-08 33.6 6.6 2.8 2 1 0 2 2 2 1 PAP2 superfamily Dynamin_M PF01031.20 CCM00221.1 - 3.3e-27 95.5 0.0 4.5e-26 91.7 0.0 2.3 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CCM00221.1 - 1.2e-11 44.9 0.1 1.1e-10 41.9 0.1 2.2 1 1 0 1 1 1 1 Dynamin family GED PF02212.18 CCM00221.1 - 8.4e-06 25.9 1.1 2.6e-05 24.3 1.1 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain DUF1476 PF07345.11 CCM00221.1 - 0.0099 16.2 0.0 1.2 9.5 0.0 3.4 3 0 0 3 3 3 1 ATPase inhibitor subunit zeta Fer4_12 PF13353.6 CCM00221.1 - 0.083 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain Fer4_14 PF13394.6 CCM00221.1 - 0.31 11.2 2.0 0.51 10.5 0.0 2.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain Pectinesterase PF01095.19 CCM00222.1 - 2e-22 79.3 0.1 2.1e-18 66.1 0.1 2.1 2 0 0 2 2 2 2 Pectinesterase DUF3905 PF13045.6 CCM00222.1 - 0.03 14.3 0.0 0.091 12.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3905) SMC_N PF02463.19 CCM00223.1 - 2.3e-64 216.9 10.1 2.2e-36 125.4 0.6 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCM00223.1 - 6.6e-22 78.0 0.6 1.6e-20 73.6 0.1 2.8 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCM00223.1 - 5.7e-11 42.8 4.9 6.6e-05 22.9 0.3 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCM00223.1 - 7.2e-08 33.2 32.5 7.2e-08 33.2 32.5 7.7 2 2 1 4 4 4 1 AAA domain AAA_15 PF13175.6 CCM00223.1 - 5.5e-07 29.6 0.5 5.5e-07 29.6 0.5 4.4 2 2 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 CCM00223.1 - 6.5e-05 22.6 0.0 0.00019 21.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.11 CCM00223.1 - 0.0023 16.9 21.6 0.0023 16.9 21.6 6.3 2 2 4 6 6 6 4 Spc7 kinetochore protein Filament PF00038.21 CCM00223.1 - 1.3 8.6 95.2 0.22 11.0 4.5 6.6 4 2 1 5 5 5 0 Intermediate filament protein ATG16 PF08614.11 CCM00223.1 - 3 8.0 100.1 0.037 14.2 7.9 6.4 3 2 3 6 6 6 0 Autophagy protein 16 (ATG16) DUF262 PF03235.14 CCM00224.1 - 0.032 14.4 0.3 0.032 14.4 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function DUF262 RP-C PF03428.13 CCM00224.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Replication protein C N-terminal domain OPT PF03169.15 CCM00225.1 - 1.1e-187 625.4 57.6 1.3e-187 625.2 57.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Pro_isomerase PF00160.21 CCM00226.1 - 8.4e-50 169.1 0.5 9.7e-50 168.9 0.5 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF1708 PF08101.11 CCM00227.1 - 3.2e-15 56.2 0.0 8.5e-13 48.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1708) DNA_primase_S PF01896.19 CCM00228.1 - 8.7e-55 185.5 0.1 1.2e-54 185.1 0.1 1.2 1 0 0 1 1 1 1 DNA primase small subunit ABC_tran PF00005.27 CCM00229.1 - 5.3e-49 166.3 0.0 1.6e-28 99.9 0.0 2.9 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 CCM00229.1 - 2e-42 145.7 22.3 2.2e-26 93.1 4.8 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 CCM00229.1 - 4.7e-08 32.7 2.1 0.0039 16.7 0.6 3.6 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCM00229.1 - 0.0018 18.0 0.6 0.37 10.6 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CCM00229.1 - 0.0032 17.7 0.4 7.2 6.9 0.1 3.2 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCM00229.1 - 0.0036 16.9 0.0 1 8.9 0.1 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 CCM00229.1 - 0.017 15.3 0.0 0.04 14.0 0.0 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_16 PF13191.6 CCM00229.1 - 0.024 15.0 0.0 0.71 10.2 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 CCM00229.1 - 0.026 14.4 0.4 49 3.6 0.0 3.9 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system ATPase PF06745.13 CCM00229.1 - 0.19 11.0 0.0 22 4.3 0.0 2.4 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.22 CCM00229.1 - 0.21 10.8 0.1 5.9 6.0 0.0 2.7 4 0 0 4 4 4 0 NB-ARC domain AAA_23 PF13476.6 CCM00229.1 - 0.21 12.1 0.5 23 5.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain DUF716 PF04819.12 CCM00229.1 - 1.6 8.4 7.4 0.29 10.8 2.3 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF716) TMEM169 PF15052.6 CCM00230.1 - 0.17 12.0 2.5 0.21 11.7 2.5 1.1 1 0 0 1 1 1 0 TMEM169 protein family EMP24_GP25L PF01105.24 CCM00231.1 - 3.4e-38 131.4 0.0 3.9e-38 131.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Trimer_CC PF08954.11 CCM00231.1 - 0.0045 16.5 0.1 0.008 15.7 0.1 1.3 1 0 0 1 1 1 1 Trimerisation motif Dus PF01207.17 CCM00232.1 - 2.9e-53 181.0 0.0 3.6e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 CCM00232.1 - 0.018 14.5 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein ThiG PF05690.14 CCM00232.1 - 0.022 14.1 0.0 0.043 13.1 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 CCM00232.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain IGPS PF00218.21 CCM00232.1 - 0.21 10.8 0.0 0.34 10.0 0.0 1.3 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase adh_short_C2 PF13561.6 CCM00233.1 - 3e-58 197.1 0.0 3.8e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM00233.1 - 5.2e-54 182.7 0.1 7.1e-54 182.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM00233.1 - 2.8e-15 56.7 0.3 3.9e-15 56.2 0.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM00233.1 - 0.00011 21.7 0.3 0.00024 20.7 0.1 1.7 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCM00233.1 - 0.0046 16.1 0.2 0.03 13.4 0.1 2.0 2 0 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCM00233.1 - 0.044 13.2 0.0 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase CBP PF12192.8 CCM00233.1 - 0.16 12.2 1.7 0.37 11.0 1.7 1.6 1 0 0 1 1 1 0 Fungal calcium binding protein Glyco_transf_5 PF08323.11 CCM00233.1 - 0.18 11.5 0.0 4.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Starch synthase catalytic domain ADH_zinc_N PF00107.26 CCM00234.1 - 1.5e-18 67.1 0.1 6.3e-12 45.6 0.0 2.2 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCM00234.1 - 8.7e-08 31.9 0.0 0.0011 18.5 0.1 3.1 2 1 1 3 3 3 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCM00234.1 - 0.0002 20.7 0.0 0.00036 19.9 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CCM00234.1 - 0.00089 20.3 0.0 0.013 16.6 0.0 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Tubulin_2 PF13809.6 CCM00234.1 - 0.0081 15.4 0.0 0.011 15.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin like Methyltransf_25 PF13649.6 CCM00234.1 - 0.021 15.5 0.2 0.058 14.1 0.2 1.9 1 1 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 CCM00234.1 - 0.024 14.2 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_11 PF08241.12 CCM00234.1 - 0.027 15.1 0.1 0.07 13.8 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain 2-Hacid_dh_C PF02826.19 CCM00234.1 - 0.084 12.2 0.0 0.22 10.9 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CCM00234.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_2 PF00891.18 CCM00235.1 - 4.9e-23 81.5 0.0 5e-19 68.4 0.0 2.2 2 0 0 2 2 2 2 O-methyltransferase domain Methyltransf_PK PF05891.12 CCM00235.1 - 0.0099 15.4 0.0 0.041 13.4 0.0 1.9 2 0 0 2 2 2 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 CCM00235.1 - 0.03 15.0 0.0 0.097 13.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain MR_MLE_C PF13378.6 CCM00236.1 - 5.1e-51 173.3 0.0 2.3e-50 171.2 0.0 1.9 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CCM00236.1 - 5.3e-21 75.0 0.0 1.1e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Peptidase_S41 PF03572.18 CCM00236.1 - 7.2e-05 22.4 0.0 0.00015 21.4 0.0 1.5 1 1 0 1 1 1 1 Peptidase family S41 PWI PF01480.17 CCM00237.1 - 1.6e-27 95.6 0.0 2.3e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 PWI domain SET PF00856.28 CCM00238.1 - 7.6e-12 45.9 0.0 2.7e-11 44.2 0.0 1.8 1 1 0 1 1 1 1 SET domain COX7C PF02935.16 CCM00239.1 - 0.16 12.2 0.6 0.42 10.9 0.6 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc DUF357 PF04010.13 CCM00239.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF357) SPC25 PF06703.11 CCM00240.1 - 2.7e-44 150.8 0.0 3.3e-44 150.5 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) ERG2_Sigma1R PF04622.12 CCM00241.1 - 7.3e-93 309.7 0.0 8.3e-93 309.5 0.0 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein GST_C_3 PF14497.6 CCM00242.1 - 9.2e-24 83.5 0.0 1.6e-23 82.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCM00242.1 - 0.00016 21.8 0.0 0.00037 20.7 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain NADH_u_ox_C PF12853.7 CCM00242.1 - 0.013 15.5 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit GST_N PF02798.20 CCM00242.1 - 0.054 13.8 0.0 0.49 10.8 0.0 2.3 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM00242.1 - 0.065 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Amino_oxidase PF01593.24 CCM00243.1 - 1.8e-22 80.3 0.0 2.5e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCM00243.1 - 6.7e-10 39.1 0.0 2.1e-09 37.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM00243.1 - 4e-06 26.6 0.1 1.2e-05 25.1 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM00243.1 - 0.00021 20.6 0.0 0.00049 19.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM00243.1 - 0.006 15.8 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 CCM00243.1 - 0.018 15.1 0.0 0.065 13.2 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding MCRA PF06100.11 CCM00243.1 - 0.024 13.4 0.0 0.036 12.9 0.0 1.2 1 0 0 1 1 1 0 MCRA family Trp_halogenase PF04820.14 CCM00243.1 - 0.1 11.4 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 CCM00243.1 - 0.16 12.5 0.0 0.45 11.1 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DSPc PF00782.20 CCM00244.1 - 3.2e-29 101.4 0.0 3.9e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCM00244.1 - 0.0065 16.1 0.0 0.0083 15.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 CCM00244.1 - 0.11 12.1 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Nitr_red_bet_C PF14711.6 CCM00244.1 - 0.14 11.9 0.2 0.84 9.4 0.0 2.1 2 0 0 2 2 2 0 Respiratory nitrate reductase beta C-terminal Init_tRNA_PT PF04179.12 CCM00244.1 - 0.14 12.5 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain Med4 PF10018.9 CCM00245.1 - 2e-20 73.3 0.0 3e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 ZZ PF00569.17 CCM00246.1 - 3.5e-17 61.9 60.8 2.5e-07 30.4 11.7 6.1 6 0 0 6 6 6 3 Zinc finger, ZZ type PB1 PF00564.24 CCM00246.1 - 4.3e-13 49.0 0.1 9.6e-13 47.9 0.1 1.6 1 0 0 1 1 1 1 PB1 domain C1_2 PF03107.16 CCM00246.1 - 1.2e-07 31.9 48.5 0.041 14.2 8.9 5.5 5 0 0 5 5 5 5 C1 domain Voltage_CLC PF00654.20 CCM00247.1 - 1.7e-83 280.8 29.1 1.7e-83 280.8 29.1 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CCM00247.1 - 3.5e-09 37.0 0.0 0.0028 18.1 0.0 2.7 2 0 0 2 2 2 2 CBS domain Methyltransf_25 PF13649.6 CCM00248.1 - 9.7e-11 42.2 0.0 1.6e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00248.1 - 2.9e-08 34.2 0.0 6.7e-08 33.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM00248.1 - 1.5e-06 28.1 0.0 1.9e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCM00248.1 - 0.027 14.4 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Tmemb_14 PF03647.13 CCM00249.1 - 3.3e-19 69.4 5.9 3.9e-19 69.2 5.9 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Methyltransf_28 PF02636.17 CCM00250.1 - 2.9e-37 128.7 0.0 4.9e-37 128.0 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 CCM00250.1 - 0.0024 17.0 0.0 0.0044 16.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase NepR PF18557.1 CCM00250.1 - 0.0041 16.7 0.5 0.47 10.1 0.2 2.7 2 0 0 2 2 2 1 Anti-sigma factor NepR Methyltransf_25 PF13649.6 CCM00250.1 - 0.032 14.9 0.0 1.2 9.9 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCM00250.1 - 0.21 12.3 0.0 0.96 10.2 0.0 2.1 3 0 0 3 3 3 0 Methyltransferase domain MMS19_C PF12460.8 CCM00251.1 - 1.3e-94 317.8 0.4 4e-81 273.3 0.0 2.9 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 CCM00251.1 - 2.4e-94 315.8 0.1 1.1e-91 307.1 0.0 2.9 2 0 0 2 2 2 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 CCM00251.1 - 0.00045 20.5 4.7 0.054 13.9 0.1 5.0 5 1 0 6 6 6 1 HEAT repeats DUF4800 PF16057.5 CCM00251.1 - 0.0048 16.2 0.0 0.0094 15.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) HEAT_EZ PF13513.6 CCM00251.1 - 0.03 14.8 0.1 0.03 14.8 0.1 4.4 6 0 0 6 6 6 0 HEAT-like repeat HEAT PF02985.22 CCM00251.1 - 1.5 9.3 5.6 1.4e+02 3.2 0.0 4.9 4 0 0 4 4 4 0 HEAT repeat PRiA4_ORF3 PF07929.11 CCM00254.1 - 6.1e-22 78.2 0.1 8.9e-22 77.6 0.1 1.3 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein zf-MYND PF01753.18 CCM00254.1 - 3.3e-11 43.1 11.5 5.4e-11 42.4 11.5 1.4 1 0 0 1 1 1 1 MYND finger RRM_1 PF00076.22 CCM00255.1 - 2.1e-29 101.1 1.5 1.3e-13 50.6 0.0 5.2 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM00255.1 - 4.2e-06 26.8 0.0 0.0039 17.3 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif RRM_occluded PF16842.5 CCM00255.1 - 0.00082 19.2 0.0 0.67 9.9 0.0 3.3 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_9 PF18444.1 CCM00255.1 - 0.041 13.7 0.0 8.7 6.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif Fis1_TPR_C PF14853.6 CCM00257.1 - 2.5e-24 85.1 0.9 4.2e-24 84.4 0.9 1.4 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 CCM00257.1 - 5.1e-17 61.3 0.0 1e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 CCM00257.1 - 0.0025 17.8 0.4 0.006 16.6 0.4 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCM00257.1 - 0.026 14.3 0.8 0.052 13.4 0.8 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Gram_pos_anchor PF00746.21 CCM00257.1 - 0.35 10.8 1.3 0.56 10.2 1.3 1.3 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Peptidase_M50B PF13398.6 CCM00258.1 - 2.4e-42 144.9 15.0 5.6e-42 143.6 15.0 1.5 1 1 0 1 1 1 1 Peptidase M50B-like Histone PF00125.24 CCM00259.1 - 4.6e-18 65.8 0.0 5.8e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CCM00259.1 - 7.7e-16 57.5 1.0 1.6e-15 56.5 1.0 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CCM00259.1 - 1.5e-06 28.4 0.0 2.1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RhoGAP PF00620.27 CCM00260.1 - 1e-07 31.9 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 CCM00260.1 - 2.5e-06 27.7 0.3 8.8e-06 25.9 0.0 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DEP PF00610.21 CCM00260.1 - 0.023 14.7 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Ribonucleas_3_3 PF14622.6 CCM00261.1 - 1.1e-07 32.1 0.0 2.1e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 CCM00261.1 - 1.9e-06 28.5 0.0 3.5e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 CCM00261.1 - 0.00022 21.8 0.0 0.00042 20.9 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain TPR_1 PF00515.28 CCM00262.1 - 9.5e-22 75.9 5.9 4.5e-07 29.4 0.1 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCM00262.1 - 3.9e-19 67.2 12.2 1.2e-06 28.1 0.2 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCM00262.1 - 5.7e-14 51.5 2.1 0.00015 21.4 0.1 5.0 4 1 1 5 5 5 3 TPR repeat TPR_8 PF13181.6 CCM00262.1 - 1.1e-13 50.1 1.2 0.025 14.8 0.0 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCM00262.1 - 1.9e-12 46.9 15.3 6.3e-05 23.5 0.1 5.7 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCM00262.1 - 8.6e-12 44.6 6.8 0.18 12.2 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCM00262.1 - 2.9e-11 43.7 11.4 5.4e-07 30.0 0.6 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCM00262.1 - 1.3e-10 41.7 10.7 1.2e-05 25.9 1.3 4.1 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 CCM00262.1 - 5.7e-09 36.0 8.4 5.4e-06 26.5 0.8 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCM00262.1 - 6.4e-09 36.0 11.4 0.0016 18.7 1.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM00262.1 - 2.7e-05 24.3 2.5 0.0012 19.0 0.3 3.1 3 1 0 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CCM00262.1 - 0.00012 21.8 8.8 0.46 10.6 0.0 5.4 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 CCM00262.1 - 0.00025 21.3 6.8 0.55 10.6 0.3 4.0 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCM00262.1 - 0.0017 18.9 2.8 51 4.8 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 CCM00262.1 - 0.0084 16.8 0.2 8.1 7.3 0.0 3.0 2 0 0 2 2 2 1 Sel1 repeat Mu-like_Pro PF10123.9 CCM00262.1 - 0.043 13.4 1.0 0.4 10.2 0.3 2.2 2 0 0 2 2 2 0 Mu-like prophage I protein TPR_10 PF13374.6 CCM00262.1 - 0.066 13.1 15.0 0.13 12.1 0.4 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat NYD-SP12_N PF15015.6 CCM00262.1 - 0.11 10.8 0.1 0.18 10.1 0.1 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal MIT PF04212.18 CCM00262.1 - 0.2 11.8 7.4 13 6.0 0.1 4.6 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain Wzy_C_2 PF11846.8 CCM00262.1 - 0.45 10.4 2.3 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal PRA1 PF03208.19 CCM00263.1 - 8.6e-37 125.9 0.3 1e-36 125.7 0.3 1.0 1 0 0 1 1 1 1 PRA1 family protein PSI_PsaJ PF01701.18 CCM00263.1 - 8.1 7.1 7.5 11 6.6 1.5 2.5 2 0 0 2 2 2 0 Photosystem I reaction centre subunit IX / PsaJ PAS PF00989.25 CCM00264.1 - 0.034 14.1 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 PAS fold Methyltransf_31 PF13847.6 CCM00265.1 - 7.6e-06 25.8 0.1 2.2e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PrmC_N PF17827.1 CCM00265.1 - 1.9e-05 25.2 0.0 5.2e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 PrmC N-terminal domain Methyltransf_25 PF13649.6 CCM00265.1 - 0.0001 22.9 0.0 0.00048 20.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CCM00265.1 - 0.0021 17.5 0.0 0.0033 16.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCM00265.1 - 0.0058 16.2 0.2 0.02 14.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_23 PF13489.6 CCM00265.1 - 0.059 13.2 0.0 0.084 12.7 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain AviRa PF11599.8 CCM00265.1 - 0.06 12.8 0.1 0.096 12.1 0.1 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa SBF PF01758.16 CCM00266.1 - 4.4e-50 170.1 17.9 4.4e-50 170.1 17.9 1.9 2 0 0 2 2 2 1 Sodium Bile acid symporter family adh_short_C2 PF13561.6 CCM00267.1 - 1.1e-54 185.5 0.4 1.3e-54 185.2 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM00267.1 - 3.7e-39 134.2 0.5 5e-39 133.8 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM00267.1 - 9.7e-09 35.4 1.2 7.8e-08 32.4 1.2 2.0 1 1 0 1 1 1 1 KR domain DUF3087 PF11286.8 CCM00267.1 - 0.19 11.2 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) NAD_binding_8 PF13450.6 CCM00268.1 - 1.3e-14 54.2 0.5 3.9e-14 52.6 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM00268.1 - 5.3e-07 29.5 0.0 1.2e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCM00268.1 - 0.00013 21.3 0.0 0.00025 20.3 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 CCM00268.1 - 0.00028 20.9 0.0 0.00074 19.5 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCM00268.1 - 0.00052 19.3 0.0 0.0015 17.8 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCM00268.1 - 0.0014 18.0 0.0 0.0041 16.5 0.0 1.8 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CCM00268.1 - 0.0034 16.1 0.0 0.012 14.4 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 CCM00268.1 - 0.0055 15.8 0.0 0.0081 15.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CCM00268.1 - 0.006 16.0 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCM00268.1 - 0.013 16.0 0.0 0.6 10.7 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM00268.1 - 0.041 13.1 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 CCM00268.1 - 0.09 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus FKBP_C PF00254.28 CCM00269.1 - 1.2e-29 102.5 0.1 2.5e-29 101.4 0.1 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 CCM00269.1 - 4e-22 78.8 0.0 4e-22 78.8 0.0 2.5 2 1 0 2 2 2 1 Nucleoplasmin-like domain CENP-B_dimeris PF09026.10 CCM00269.1 - 0.046 14.1 2.1 0.046 14.1 2.1 4.0 2 1 1 4 4 4 0 Centromere protein B dimerisation domain Presenilin PF01080.17 CCM00269.1 - 2.2 7.0 7.5 0.51 9.0 4.4 1.5 2 0 0 2 2 2 0 Presenilin Scs3p PF10261.9 CCM00270.1 - 7.9e-41 140.2 1.9 1.1e-33 116.8 0.0 2.2 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM Lig_chan PF00060.26 CCM00270.1 - 0.22 11.4 2.5 0.79 9.5 0.4 2.2 2 1 0 2 2 2 0 Ligand-gated ion channel ALAD PF00490.21 CCM00271.1 - 2.6e-122 408.0 0.0 3.2e-122 407.7 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Pkinase PF00069.25 CCM00272.1 - 2.1e-40 138.7 0.0 2.9e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00272.1 - 1.4e-25 90.1 0.0 2.1e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM00272.1 - 0.032 14.2 1.9 0.25 11.2 0.0 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family PPR_2 PF13041.6 CCM00275.1 - 9.2e-06 25.8 0.1 0.012 15.8 0.0 4.4 3 1 1 4 4 4 2 PPR repeat family PPR_3 PF13812.6 CCM00275.1 - 0.00015 21.8 0.0 0.5 10.5 0.0 3.2 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_long PF17177.4 CCM00275.1 - 0.049 13.0 0.0 4.4 6.6 0.0 2.3 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP HD PF01966.22 CCM00278.1 - 1.6e-11 44.5 0.0 4.1e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 HD domain PDEase_I PF00233.19 CCM00278.1 - 0.004 16.9 0.3 0.011 15.4 0.3 1.7 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD_2 PF12917.7 CCM00278.1 - 0.084 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme Phg_2220_C PF09524.10 CCM00278.1 - 0.13 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Conserved phage C-terminus (Phg_2220_C) BTB PF00651.31 CCM00279.1 - 0.0021 18.3 0.0 0.0057 16.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain HAP1_N PF04849.13 CCM00280.1 - 0.00047 19.4 19.5 0.00047 19.4 19.5 3.5 2 1 0 3 3 3 2 HAP1 N-terminal conserved region DUF4201 PF13870.6 CCM00280.1 - 0.0018 18.0 4.6 0.0018 18.0 4.6 4.7 2 2 2 4 4 4 1 Domain of unknown function (DUF4201) DUF4549 PF15082.6 CCM00280.1 - 0.0055 16.5 2.7 0.0055 16.5 2.7 3.1 3 2 1 5 5 5 1 Domain of unknown function (DUF4549) HALZ PF02183.18 CCM00280.1 - 0.037 14.3 0.3 0.037 14.3 0.3 5.0 5 0 0 5 5 5 0 Homeobox associated leucine zipper DUF4618 PF15397.6 CCM00281.1 - 0.0094 15.4 6.4 0.02 14.4 6.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Phage_GP20 PF06810.11 CCM00281.1 - 0.047 13.5 7.1 0.35 10.7 0.3 2.5 1 1 0 2 2 2 0 Phage minor structural protein GP20 YbgS PF13985.6 CCM00281.1 - 0.39 11.0 7.9 2.1 8.7 4.4 2.4 2 0 0 2 2 2 0 YbgS-like protein DUF1192 PF06698.11 CCM00281.1 - 1.1 9.3 5.7 3.1 7.9 1.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) CorA PF01544.18 CCM00281.1 - 2.5 7.3 7.1 1.3 8.3 4.1 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Syntaxin-6_N PF09177.11 CCM00281.1 - 3 8.4 7.5 1.5 9.4 0.9 2.7 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DivIC PF04977.15 CCM00281.1 - 5.3 6.9 11.3 4.2 7.2 0.2 3.6 3 1 0 3 3 3 0 Septum formation initiator TPR_MLP1_2 PF07926.12 CCM00281.1 - 6.7 6.8 22.2 2.1 8.4 2.0 3.9 1 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 CCM00281.1 - 8.6 6.4 14.5 1.2e+03 -0.6 14.5 2.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Glyco_hydro_17 PF00332.18 CCM00282.1 - 0.056 13.0 0.1 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 DUF1707 PF08044.11 CCM00282.1 - 0.24 11.5 4.3 6.1 7.0 0.1 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) Exotox-A_target PF09102.10 CCM00282.1 - 0.32 11.0 5.0 0.17 11.9 0.6 2.8 3 1 1 4 4 4 0 Exotoxin A, targeting Spc7 PF08317.11 CCM00282.1 - 0.36 9.7 51.6 0.065 12.1 10.9 3.6 2 1 1 3 3 3 0 Spc7 kinetochore protein Prp19 PF08606.11 CCM00282.1 - 0.54 10.3 16.3 0.91 9.6 0.3 4.9 4 1 1 5 5 5 0 Prp19/Pso4-like MR_MLE_C PF13378.6 CCM00283.1 - 0.15 11.6 0.0 0.2 11.2 0.0 1.3 1 1 0 1 1 1 0 Enolase C-terminal domain-like 3Beta_HSD PF01073.19 CCM00283.1 - 0.19 10.7 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 CCM00284.1 - 5.5e-20 71.7 0.2 1.3e-17 64.0 0.6 2.4 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00284.1 - 2.2e-10 40.5 0.2 3e-10 40.0 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM00284.1 - 1.8e-08 34.5 0.3 2.7e-08 33.9 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM00284.1 - 4.2e-05 23.1 0.2 6.4e-05 22.5 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DOT1 PF08123.13 CCM00284.1 - 0.0034 16.9 0.0 0.0054 16.3 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Shikimate_DH PF01488.20 CCM00284.1 - 0.0043 17.1 0.3 0.0095 16.0 0.2 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 CCM00284.1 - 0.079 12.3 0.0 0.12 11.8 0.0 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCM00284.1 - 0.12 11.5 0.5 0.2 10.7 0.1 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_4 PF07993.12 CCM00284.1 - 0.2 10.8 0.1 0.86 8.7 0.1 2.0 1 1 0 1 1 1 0 Male sterility protein NmrA PF05368.13 CCM00285.1 - 7.2e-32 110.8 0.0 1e-31 110.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCM00285.1 - 1.9e-16 60.5 0.7 1.5e-14 54.3 0.7 2.3 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCM00285.1 - 6.4e-07 29.1 1.2 1.7e-05 24.4 1.2 3.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCM00285.1 - 1.4e-05 25.1 2.9 0.00011 22.2 1.6 2.6 2 1 0 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 CCM00285.1 - 0.00025 20.6 0.0 0.00045 19.7 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCM00285.1 - 0.00066 19.2 2.6 0.011 15.2 2.3 2.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00285.1 - 0.00077 19.1 0.2 0.0014 18.3 0.2 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CCM00285.1 - 0.013 14.7 0.1 0.024 13.8 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CCM00285.1 - 0.021 13.8 0.0 0.065 12.2 0.0 1.8 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM00285.1 - 0.03 13.5 0.0 2.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Male sterility protein RmlD_sub_bind PF04321.17 CCM00285.1 - 0.49 9.5 2.1 1.5 7.9 1.7 2.0 2 1 0 2 2 2 0 RmlD substrate binding domain Acetyltransf_7 PF13508.7 CCM00286.1 - 1e-07 32.3 0.1 2.8e-07 30.9 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCM00286.1 - 1.4e-07 31.5 0.0 2.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM00286.1 - 8.3e-06 25.7 0.8 0.00064 19.6 0.1 2.4 1 1 1 2 2 2 2 FR47-like protein Acetyltransf_1 PF00583.25 CCM00286.1 - 8.5e-06 26.0 0.0 1.8e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CCM00286.1 - 0.005 16.9 0.0 0.018 15.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain RII_binding_1 PF10522.9 CCM00286.1 - 0.0078 16.3 0.0 0.034 14.3 0.0 2.0 2 0 0 2 2 2 1 RII binding domain Acetyltransf_7 PF13508.7 CCM00287.1 - 2e-07 31.4 0.1 3.3e-07 30.6 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCM00287.1 - 1.1e-06 28.6 0.0 1.6e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM00287.1 - 2.2e-06 27.9 0.0 3.3e-06 27.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CCM00287.1 - 0.00085 19.4 0.0 0.0018 18.3 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM00287.1 - 0.0012 18.8 0.1 0.0028 17.6 0.1 1.7 1 1 0 1 1 1 1 FR47-like protein RII_binding_1 PF10522.9 CCM00287.1 - 0.014 15.5 0.0 0.037 14.2 0.0 1.7 1 0 0 1 1 1 0 RII binding domain Metallophos PF00149.28 CCM00290.1 - 2.6e-27 96.7 0.0 3.9e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 CCM00290.1 - 0.14 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain ABC_tran PF00005.27 CCM00291.1 - 2.4e-49 167.4 0.1 1.8e-24 86.8 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CCM00291.1 - 5.6e-21 74.4 4.3 5.6e-21 74.4 4.3 2.1 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 CCM00291.1 - 2.3e-16 60.5 4.7 0.00048 20.0 0.1 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM00291.1 - 3.8e-10 39.6 3.0 0.047 13.1 0.5 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM00291.1 - 2.6e-09 37.9 7.3 0.00053 20.6 0.0 3.8 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.6 CCM00291.1 - 5.5e-09 36.6 0.0 0.00019 21.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CCM00291.1 - 8.8e-09 35.0 0.2 0.0014 18.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCM00291.1 - 6.2e-07 29.5 0.9 0.0021 18.0 0.0 3.4 3 0 0 3 3 3 1 RsgA GTPase MMR_HSR1 PF01926.23 CCM00291.1 - 4e-06 26.9 0.2 0.0035 17.4 0.0 3.2 4 0 0 4 4 2 1 50S ribosome-binding GTPase NACHT PF05729.12 CCM00291.1 - 9e-06 25.7 0.1 0.097 12.6 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_24 PF13479.6 CCM00291.1 - 0.00024 20.9 0.2 1 9.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 CCM00291.1 - 0.00025 20.9 14.7 0.088 12.5 0.0 4.6 4 1 0 4 4 3 1 AAA ATPase domain AAA_18 PF13238.6 CCM00291.1 - 0.00027 21.5 0.1 0.48 11.0 0.0 3.3 4 0 0 4 4 3 1 AAA domain AAA_22 PF13401.6 CCM00291.1 - 0.00028 21.2 0.4 0.4 10.9 0.2 3.3 2 2 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCM00291.1 - 0.00034 21.0 1.9 3.5 8.1 0.0 3.5 3 0 0 3 3 3 1 RNA helicase AAA_30 PF13604.6 CCM00291.1 - 0.00047 19.9 0.0 0.071 12.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 CCM00291.1 - 0.00068 19.7 11.7 0.089 12.8 0.5 4.4 2 2 0 3 3 3 2 Dynamin family AAA_25 PF13481.6 CCM00291.1 - 0.001 18.7 0.0 5.6 6.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 CCM00291.1 - 0.0031 16.7 0.0 1.2 8.3 0.0 2.6 3 0 0 3 3 3 1 NB-ARC domain AAA PF00004.29 CCM00291.1 - 0.0039 17.6 0.1 4.6 7.7 0.0 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 CCM00291.1 - 0.004 17.3 5.4 0.96 9.5 0.2 4.0 3 2 2 5 5 5 1 Helicase HerA, central domain AAA_5 PF07728.14 CCM00291.1 - 0.0041 17.1 0.0 3.6 7.6 0.0 3.2 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 CCM00291.1 - 0.0044 16.4 0.1 1.2 8.5 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_33 PF13671.6 CCM00291.1 - 0.0044 17.2 0.1 6.4 6.9 0.0 3.3 3 1 0 3 3 3 0 AAA domain AAA_28 PF13521.6 CCM00291.1 - 0.0046 17.2 0.0 0.94 9.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 CCM00291.1 - 0.005 17.1 0.0 6.3 7.0 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 CCM00291.1 - 0.0072 15.8 0.1 0.63 9.5 0.0 2.9 3 0 0 3 3 2 1 P-loop containing dynein motor region FeoB_N PF02421.18 CCM00291.1 - 0.0075 15.8 0.0 0.071 12.6 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B Septin PF00735.18 CCM00291.1 - 0.016 14.5 0.0 3.9 6.7 0.0 3.1 3 0 0 3 3 3 0 Septin TsaE PF02367.17 CCM00291.1 - 0.025 14.6 0.1 11 6.0 0.0 3.4 2 1 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 CCM00291.1 - 0.025 14.4 0.2 8.5 6.1 0.0 3.2 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.12 CCM00291.1 - 0.025 13.8 0.0 0.59 9.4 0.0 2.8 3 0 0 3 3 3 0 Zeta toxin ATP-synt_ab PF00006.25 CCM00291.1 - 0.027 14.1 0.0 1.1 8.9 0.0 2.6 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain KAP_NTPase PF07693.14 CCM00291.1 - 0.035 13.4 0.1 4.6 6.4 0.0 2.6 2 1 0 2 2 2 0 KAP family P-loop domain MtrA PF04208.14 CCM00291.1 - 0.038 13.6 0.7 0.08 12.6 0.2 1.7 2 0 0 2 2 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A AAA_27 PF13514.6 CCM00291.1 - 0.05 13.2 0.0 9.8 5.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.6 CCM00291.1 - 0.07 13.6 1.3 5.2 7.5 0.0 3.8 4 0 0 4 4 3 0 AAA domain SbcCD_C PF13558.6 CCM00291.1 - 0.13 12.5 1.2 9.3 6.6 0.0 3.4 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 CCM00291.1 - 0.16 11.1 3.1 3.5 6.7 0.6 2.9 3 1 0 3 3 3 0 G-protein alpha subunit Pox_A32 PF04665.12 CCM00291.1 - 0.22 11.0 3.1 5.6 6.4 0.1 3.0 3 1 0 3 3 3 0 Poxvirus A32 protein NTPase_1 PF03266.15 CCM00291.1 - 0.44 10.4 7.0 1.8 8.5 0.1 3.8 5 0 0 5 5 5 0 NTPase DivIC PF04977.15 CCM00291.1 - 0.53 10.1 9.9 2.3 8.0 2.6 2.6 2 0 0 2 2 2 0 Septum formation initiator DUF3987 PF13148.6 CCM00291.1 - 1.1 8.2 5.3 1.4 7.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) Ribosomal_L1 PF00687.21 CCM00292.1 - 1.9e-47 161.6 1.6 2.2e-47 161.4 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Clathrin PF00637.20 CCM00293.1 - 2.4e-23 82.6 0.1 2.9e-22 79.1 0.1 2.7 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.9 CCM00293.1 - 0.00022 21.4 0.2 0.0049 17.1 0.0 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Ribosomal_L7Ae PF01248.26 CCM00294.1 - 6.2e-27 93.2 2.9 7.6e-27 92.9 2.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family WD40 PF00400.32 CCM00295.1 - 4.7e-13 49.4 2.8 1e-05 26.2 0.6 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00295.1 - 1.2e-06 28.7 0.1 0.00099 19.4 0.0 3.7 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCM00295.1 - 0.31 11.0 5.6 1.2 9.2 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat GST_N PF02798.20 CCM00296.1 - 6.5e-22 77.7 0.1 1.6e-20 73.2 0.1 2.7 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM00296.1 - 2.7e-16 59.6 0.1 6.3e-16 58.4 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCM00296.1 - 1.4e-14 54.3 0.0 2.6e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM00296.1 - 2.5e-13 50.1 0.0 4.7e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCM00296.1 - 4.3e-11 42.9 0.1 1.1e-10 41.5 0.0 1.7 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM00296.1 - 8.7e-06 25.7 0.0 1.9e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCM00296.1 - 0.00084 19.9 0.0 0.13 12.9 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.10 CCM00296.1 - 0.099 13.2 0.1 0.26 11.9 0.0 1.7 2 0 0 2 2 2 0 MetRS-N binding domain DUF2892 PF11127.8 CCM00297.1 - 4.1 7.5 8.0 2 8.5 0.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2892) adh_short PF00106.25 CCM00298.1 - 1.1e-17 64.2 0.0 1.4e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00298.1 - 1.8e-16 60.4 0.0 2.3e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Hydantoinase_A PF01968.18 CCM00300.1 - 1.4e-84 283.8 0.0 2.6e-84 282.9 0.0 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CCM00300.1 - 7e-56 188.7 0.1 8.6e-53 178.7 0.0 2.3 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region NIF PF03031.18 CCM00301.1 - 5e-14 52.4 0.0 6.8e-13 48.7 0.0 2.3 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase RNase_PH PF01138.21 CCM00302.1 - 1e-18 68.1 0.0 1.6e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCM00302.1 - 1.3e-08 34.8 0.0 2.1e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 RNA_pol_Rpb4 PF03874.16 CCM00302.1 - 0.11 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb4 Trm112p PF03966.16 CCM00303.1 - 2.1e-20 73.1 0.0 2.4e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein zf-ribbon_3 PF13248.6 CCM00303.1 - 0.0015 17.9 0.1 0.0025 17.1 0.1 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zf-NADH-PPase PF09297.11 CCM00303.1 - 0.013 15.2 0.2 0.025 14.3 0.2 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 CCM00303.1 - 0.03 14.0 0.1 0.06 13.1 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain A2L_zn_ribbon PF08792.10 CCM00303.1 - 0.038 13.7 0.0 0.089 12.5 0.0 1.6 1 0 0 1 1 1 0 A2L zinc ribbon domain zf-ACC PF17848.1 CCM00303.1 - 0.061 13.4 0.2 0.11 12.6 0.2 1.4 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain TF_Zn_Ribbon PF08271.12 CCM00303.1 - 0.074 12.6 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding PhnA_Zn_Ribbon PF08274.12 CCM00303.1 - 0.11 12.5 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 PhnA Zinc-Ribbon AhpC-TSA PF00578.21 CCM00304.1 - 2.3e-37 127.7 0.0 3.8e-37 127.0 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 CCM00304.1 - 1.3e-13 50.5 0.0 2.4e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 CCM00304.1 - 1.1e-12 47.9 0.0 1.5e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin Peptidase_M48 PF01435.18 CCM00306.1 - 1e-21 77.6 0.0 2.7e-21 76.2 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M48 DUF2997 PF11211.8 CCM00306.1 - 0.15 11.9 0.3 0.5 10.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2997) LamB_YcsF PF03746.16 CCM00307.1 - 1.9e-31 109.6 0.0 2.1e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family Biotin_carb_N PF00289.22 CCM00308.1 - 1.3e-36 125.5 0.0 2.1e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain CPSase_L_D2 PF02786.17 CCM00308.1 - 8.6e-16 58.1 0.1 1.4e-15 57.4 0.1 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 CCM00308.1 - 0.00013 21.6 0.0 0.019 14.5 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CCM00308.1 - 0.0025 17.4 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.11 CCM00308.1 - 0.006 16.2 0.0 0.014 15.0 0.0 1.6 2 0 0 2 2 2 1 RimK-like ATP-grasp domain CT_A_B PF02626.15 CCM00309.1 - 2.3e-82 276.6 0.0 3.5e-82 276.0 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B Biotin_carb_C PF02785.19 CCM00309.1 - 2.9e-31 107.8 0.0 5.8e-31 106.8 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain CT_C_D PF02682.16 CCM00309.1 - 7e-28 97.7 0.0 9.2e-26 90.8 0.0 2.3 1 1 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D CPSase_L_D2 PF02786.17 CCM00309.1 - 6.2e-16 58.5 0.0 1.2e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_lipoyl PF00364.22 CCM00309.1 - 1.7e-05 24.6 2.2 7.3e-05 22.5 2.2 2.0 1 1 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CCM00309.1 - 0.18 11.6 0.5 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 Biotin-lipoyl like FAD_binding_3 PF01494.19 CCM00310.1 - 1.3e-17 64.1 0.0 2e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCM00310.1 - 2e-07 31.2 0.4 5.8e-07 29.6 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain F-box-like PF12937.7 CCM00310.1 - 4.5e-05 23.3 0.1 9.2e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like Trp_halogenase PF04820.14 CCM00310.1 - 5.5e-05 22.2 1.1 0.036 12.9 0.3 2.6 2 1 1 3 3 3 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 CCM00310.1 - 7e-05 22.2 0.2 0.00027 20.3 0.2 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM00310.1 - 0.00042 20.0 1.2 0.00099 18.8 1.2 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM00310.1 - 0.00056 19.1 2.2 0.00092 18.4 2.2 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCM00310.1 - 0.00092 18.4 0.2 0.016 14.3 0.2 2.2 1 1 0 1 1 1 1 Lycopene cyclase protein Amino_oxidase PF01593.24 CCM00310.1 - 0.0049 16.2 0.1 0.018 14.3 0.3 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCM00310.1 - 0.013 14.9 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCM00310.1 - 0.025 15.2 0.0 0.061 13.9 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM00310.1 - 0.087 12.0 0.2 0.15 11.2 0.2 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 CCM00310.1 - 0.12 11.1 1.0 0.19 10.4 1.0 1.2 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 CCM00310.1 - 0.14 11.2 2.0 0.22 10.5 2.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A NOA36 PF06524.12 CCM00310.1 - 4.7 6.5 5.5 8.6 5.6 5.5 1.3 1 0 0 1 1 1 0 NOA36 protein PRELI PF04707.14 CCM00312.1 - 1.1e-37 129.3 0.0 1.6e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 PRELI-like family Phage_T4_Ndd PF06591.11 CCM00312.1 - 0.003 17.3 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 T4-like phage nuclear disruption protein (Ndd) Lactamase_B_2 PF12706.7 CCM00313.1 - 8.3e-29 100.5 0.0 2.1e-17 63.3 0.0 2.1 1 1 1 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CCM00313.1 - 2.1e-05 24.6 0.9 3.5e-05 23.9 0.9 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily MMR_HSR1_Xtn PF16897.5 CCM00314.1 - 1.3e-42 144.1 1.2 2.2e-42 143.4 1.2 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 CCM00314.1 - 1.4e-19 70.2 0.0 3e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 CCM00314.1 - 4.9e-18 64.9 0.0 1.7e-17 63.2 0.0 1.9 1 1 0 1 1 1 1 TGS domain FeoB_N PF02421.18 CCM00314.1 - 1.4e-10 40.9 0.0 2.5e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCM00314.1 - 0.0051 16.9 0.1 0.18 11.8 0.0 2.3 1 1 1 2 2 2 1 Dynamin family MCM PF00493.23 CCM00314.1 - 0.081 12.0 0.1 0.27 10.3 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain Pkinase PF00069.25 CCM00315.1 - 4.7e-66 222.8 0.0 8.7e-66 222.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00315.1 - 1.6e-36 126.0 0.1 5.8e-26 91.3 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 CCM00315.1 - 4.5e-05 22.9 0.6 0.00049 19.5 0.6 2.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 CCM00315.1 - 0.00076 19.5 0.0 0.0027 17.7 0.0 1.9 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CCM00315.1 - 0.0065 15.6 0.1 0.011 14.8 0.1 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 CCM00315.1 - 0.015 14.1 0.0 0.035 12.9 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 CCM00315.1 - 0.063 12.6 0.2 0.4 10.0 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCM00315.1 - 0.081 12.5 0.0 0.38 10.3 0.0 2.2 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 DUF2052 PF09747.9 CCM00315.1 - 0.44 10.6 3.5 5.5 7.1 0.1 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RPE65 PF03055.15 CCM00316.1 - 2.1e-106 356.9 0.0 3e-106 356.4 0.0 1.2 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Inhibitor_G39P PF11417.8 CCM00316.1 - 0.0033 17.9 0.0 0.0072 16.8 0.0 1.5 1 0 0 1 1 1 1 Loader and inhibitor of phage G40P Tmemb_cc2 PF10267.9 CCM00316.1 - 8.6 5.4 8.0 14 4.7 8.0 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein MFS_1 PF07690.16 CCM00317.1 - 1.9e-40 138.9 41.0 1.9e-40 138.9 41.0 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM00317.1 - 2.6e-09 36.1 17.0 3.6e-09 35.6 17.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM00317.1 - 6.7e-06 25.2 10.1 6.7e-06 25.2 10.1 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter M-factor PF03855.13 CCM00317.1 - 1.8 8.8 3.2 0.56 10.4 0.1 1.8 2 0 0 2 2 2 0 M-factor MFS_3 PF05977.13 CCM00317.1 - 2.9 6.2 14.9 0.034 12.5 5.9 2.0 2 0 0 2 2 2 0 Transmembrane secretion effector PRELI PF04707.14 CCM00318.1 - 9.2e-24 84.0 0.0 1.6e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 PRELI-like family B-block_TFIIIC PF04182.12 CCM00318.1 - 2e-11 43.9 0.5 1.8e-06 28.0 0.0 3.6 3 1 1 4 4 4 2 B-block binding subunit of TFIIIC MarR_2 PF12802.7 CCM00318.1 - 6.1e-07 29.2 0.4 0.017 15.0 0.0 3.9 3 0 0 3 3 3 2 MarR family HTH_24 PF13412.6 CCM00318.1 - 0.0013 18.3 0.0 0.52 9.9 0.0 3.8 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.6 CCM00318.1 - 0.012 16.1 3.1 0.93 10.0 0.0 4.1 5 0 0 5 5 5 0 Winged helix DNA-binding domain Myb_DNA-binding PF00249.31 CCM00318.1 - 0.033 14.4 0.1 0.11 12.8 0.1 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain SelB-wing_2 PF09106.11 CCM00318.1 - 0.33 11.2 1.9 5.8 7.2 0.0 3.9 4 0 0 4 4 4 0 Elongation factor SelB, winged helix MTBP_N PF14918.6 CCM00318.1 - 0.54 9.7 4.0 0.43 10.0 0.0 2.5 3 0 0 3 3 3 0 MDM2-binding Transformer PF06495.11 CCM00318.1 - 5.6 7.0 8.9 0.96 9.5 0.5 2.6 2 0 0 2 2 2 0 Fruit fly transformer protein ABC_membrane_2 PF06472.15 CCM00319.1 - 4.8e-53 180.3 1.0 2e-50 171.7 1.0 2.2 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CCM00319.1 - 2.1e-17 63.9 0.0 4.5e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCM00319.1 - 0.00018 21.4 0.0 0.00032 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CCM00319.1 - 0.0057 17.2 0.3 0.014 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CCM00319.1 - 0.047 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCM00319.1 - 0.049 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 CCM00319.1 - 0.093 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain DUF815 PF05673.13 CCM00319.1 - 0.094 11.9 0.0 0.3 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_16 PF13191.6 CCM00319.1 - 0.1 13.0 0.4 0.45 10.9 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 CCM00319.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_15 PF13175.6 CCM00319.1 - 0.14 11.8 0.1 0.33 10.6 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain NT5C PF06941.12 CCM00320.1 - 2.7e-10 40.4 0.1 2.7e-09 37.1 0.0 2.3 1 1 0 3 3 3 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) HAD_2 PF13419.6 CCM00320.1 - 0.011 15.8 0.0 0.032 14.3 0.0 1.8 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CCM00320.1 - 0.18 12.2 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase MIX PF18529.1 CCM00321.1 - 0.14 11.8 0.0 0.15 11.7 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial membrane-anchored proteins RINT1_TIP1 PF04437.13 CCM00322.1 - 1.6e-93 314.3 0.0 2.8e-93 313.5 0.0 1.3 2 0 0 2 2 2 1 RINT-1 / TIP-1 family MCM PF00493.23 CCM00323.1 - 1.5e-95 318.6 0.3 2.1e-95 318.1 0.3 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCM00323.1 - 3.6e-35 120.5 0.0 6.1e-35 119.8 0.0 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCM00323.1 - 1.5e-22 79.8 0.3 2.8e-22 78.9 0.3 1.4 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCM00323.1 - 2.4e-14 53.8 0.1 6.1e-14 52.5 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCM00323.1 - 6.6e-08 32.2 0.0 1e-06 28.3 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCM00323.1 - 0.0015 18.4 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCM00323.1 - 0.011 15.5 0.1 0.041 13.6 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Roughex PF06020.11 CCM00323.1 - 0.039 13.1 2.5 0.079 12.1 2.5 1.4 1 0 0 1 1 1 0 Drosophila roughex protein WD40 PF00400.32 CCM00325.1 - 3.1e-24 84.8 5.5 9.7e-08 32.6 0.1 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00325.1 - 2.2e-05 24.6 0.0 1.6 9.1 0.0 3.6 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCM00325.1 - 0.074 12.6 0.0 0.23 11.0 0.0 1.8 1 1 1 2 2 2 0 PQQ-like domain NESP55 PF06390.12 CCM00325.1 - 0.32 10.6 2.5 0.51 9.9 2.5 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Myb_DNA-bind_6 PF13921.6 CCM00327.1 - 5.1e-33 113.1 0.2 3e-15 56.2 0.0 3.8 2 1 2 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CCM00327.1 - 1.2e-32 111.8 8.3 7.4e-14 51.7 0.1 3.6 4 0 0 4 4 4 3 Myb-like DNA-binding domain zf-C2H2_aberr PF17017.5 CCM00327.1 - 0.0022 18.2 1.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger Rap1_C PF11626.8 CCM00327.1 - 0.013 15.6 3.6 7.6 6.7 0.7 3.3 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain zf_C2H2_ZHX PF18387.1 CCM00327.1 - 0.019 14.6 1.5 6.7 6.4 0.0 3.1 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain SANT_DAMP1_like PF16282.5 CCM00327.1 - 0.019 15.1 0.2 0.26 11.5 0.1 2.4 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 Mito_carr PF00153.27 CCM00328.1 - 1.7e-16 59.9 0.0 2.1e-06 27.5 0.0 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Spc7 PF08317.11 CCM00329.1 - 1.9e-82 276.6 10.4 2.6e-82 276.2 10.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 CCM00329.1 - 0.00032 20.7 0.0 0.00069 19.7 0.0 1.6 1 0 0 1 1 1 1 Spc7_C2 Atg14 PF10186.9 CCM00329.1 - 0.011 14.8 6.0 0.024 13.7 6.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FUSC PF04632.12 CCM00329.1 - 0.29 9.6 4.5 0.44 9.0 4.5 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4407 PF14362.6 CCM00329.1 - 0.78 9.0 10.2 0.14 11.5 6.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 CCM00329.1 - 1.7 8.2 7.7 3.2 7.3 7.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit IFT57 PF10498.9 CCM00329.1 - 2.5 7.0 15.2 0.57 9.1 10.9 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 CCM00329.1 - 2.6 8.1 8.2 1 9.4 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 CCM00329.1 - 2.7 7.2 6.2 4.1 6.6 6.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein CENP-F_leu_zip PF10473.9 CCM00329.1 - 2.8 8.0 17.8 0.18 11.8 9.4 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PspA_IM30 PF04012.12 CCM00329.1 - 3.3 7.2 18.7 7.9 6.0 18.7 1.6 1 1 0 1 1 1 0 PspA/IM30 family T3SSipB PF16535.5 CCM00329.1 - 8.2 6.9 9.9 1.8 9.0 4.8 2.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB Kinesin PF00225.23 CCM00330.1 - 8.7e-84 281.3 0.3 5.1e-83 278.8 0.0 2.2 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCM00330.1 - 1.6e-16 60.5 0.0 4.6e-13 49.4 0.0 3.5 3 1 0 3 3 3 2 Microtubule binding CLZ PF16526.5 CCM00330.1 - 0.25 11.7 11.4 0.077 13.4 5.3 3.1 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DNA_pol3_a_NII PF11490.8 CCM00330.1 - 8.5 6.3 8.1 16 5.4 8.1 1.4 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II C2 PF00168.30 CCM00331.1 - 1.8e-17 63.5 0.0 2.4e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 C2 domain PID_2 PF14719.6 CCM00331.1 - 9.3e-05 22.4 0.0 0.00013 21.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SPATA48 PF15073.6 CCM00331.1 - 0.013 15.8 0.0 0.022 15.1 0.0 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 48 C2 PF00168.30 CCM00332.1 - 1.6e-56 188.9 0.0 1.4e-15 57.4 0.0 4.5 4 0 0 4 4 4 4 C2 domain MMM1 PF10296.9 CCM00332.1 - 0.11 11.5 0.1 0.2 10.7 0.1 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF2484 PF10658.9 CCM00332.1 - 0.14 12.5 1.1 0.24 11.7 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2484) adh_short PF00106.25 CCM00333.1 - 1e-10 41.4 0.0 1.3e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00333.1 - 7.5e-09 35.5 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM00333.1 - 8.3e-07 29.1 0.0 1.1e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 KR domain LMBR1 PF04791.16 CCM00334.1 - 0.93 8.3 5.6 1.8 7.4 5.6 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Syntaxin_2 PF14523.6 CCM00334.1 - 7.8 6.9 14.9 1.5 9.3 10.4 2.2 2 0 0 2 2 2 0 Syntaxin-like protein DIE2_ALG10 PF04922.12 CCM00335.1 - 3.2e-128 428.4 4.5 3.8e-128 428.1 4.5 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family DUF3818 PF12825.7 CCM00335.1 - 0.11 11.5 0.3 0.16 11.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) MTS PF05175.14 CCM00336.1 - 0.00058 19.5 0.0 0.76 9.3 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase small domain TauD PF02668.16 CCM00337.1 - 9.7e-55 186.2 1.2 1.5e-54 185.6 1.2 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family OPT PF03169.15 CCM00338.1 - 4.7e-186 620.1 59.1 5.5e-186 619.9 59.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Prp19 PF08606.11 CCM00339.1 - 1.8e-32 111.1 1.6 1.8e-32 111.1 1.6 1.6 2 0 0 2 2 2 1 Prp19/Pso4-like WD40 PF00400.32 CCM00339.1 - 7.3e-13 48.8 0.7 0.00087 20.1 0.0 5.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00339.1 - 1.7e-12 47.5 0.0 3.7e-06 27.1 0.0 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 CCM00339.1 - 2.1e-05 24.6 0.0 9.1e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 U-box domain Frtz PF11768.8 CCM00339.1 - 0.00085 17.8 0.0 0.0015 16.9 0.0 1.4 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz zf-Nse PF11789.8 CCM00339.1 - 0.0035 17.1 0.0 0.0074 16.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 CCM00339.1 - 0.019 15.1 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 CCM00339.1 - 0.072 12.5 0.1 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Rtf2 RING-finger SGTA_dimer PF16546.5 CCM00340.1 - 2.5e-27 94.4 0.2 4.5e-27 93.6 0.2 1.4 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 CCM00340.1 - 8.7e-24 82.3 0.0 3.6e-07 29.7 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCM00340.1 - 1.8e-19 68.2 0.1 1.8e-06 27.6 0.0 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM00340.1 - 9.4e-17 60.4 1.5 5.3e-09 35.6 0.5 3.4 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 CCM00340.1 - 1e-15 56.5 0.1 0.00057 19.9 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCM00340.1 - 5.1e-11 42.2 0.4 0.00095 19.4 0.3 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM00340.1 - 1.8e-09 37.6 0.1 0.0029 18.3 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM00340.1 - 1.2e-08 35.5 0.8 6.7e-05 23.5 0.3 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCM00340.1 - 9.4e-08 31.6 0.2 0.0081 16.1 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCM00340.1 - 6.2e-06 26.4 1.9 0.032 14.5 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCM00340.1 - 1.3e-05 25.3 0.1 0.0054 16.8 0.0 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCM00340.1 - 1.3e-05 25.6 1.2 0.03 14.8 0.3 2.8 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCM00340.1 - 2.9e-05 23.8 3.4 0.13 12.2 0.4 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat STI1 PF17830.1 CCM00340.1 - 0.00078 19.3 11.4 0.033 14.1 7.8 2.7 1 1 0 2 2 2 1 STI1 domain ANAPC3 PF12895.7 CCM00340.1 - 0.016 15.4 0.3 0.29 11.4 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CCM00340.1 - 0.019 15.6 0.0 1.5 9.6 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.17 CCM00340.1 - 0.081 13.4 0.1 1.3 9.4 0.1 2.2 1 1 1 2 2 2 0 Bacterial transcriptional activator domain NUDIX PF00293.28 CCM00341.1 - 1.3e-06 28.5 0.0 2.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Pkinase PF00069.25 CCM00342.1 - 8.9e-52 176.0 0.0 1.1e-51 175.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00342.1 - 1.9e-32 112.6 0.0 3.8e-32 111.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM00342.1 - 0.00012 21.0 0.0 0.00019 20.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCM00342.1 - 0.014 14.7 0.0 0.029 13.7 0.0 1.5 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 CCM00342.1 - 0.051 13.5 0.2 0.051 13.5 0.2 2.7 3 1 0 3 3 3 0 Phosphotransferase enzyme family RRM_1 PF00076.22 CCM00343.1 - 6.9e-14 51.4 0.1 1e-13 50.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 CCM00343.1 - 1.7e-08 34.2 2.0 2.9e-08 33.4 2.0 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 CCM00343.1 - 0.00044 20.1 0.4 0.0011 18.9 0.4 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 CCM00343.1 - 0.0018 17.9 2.0 0.0063 16.2 2.0 2.0 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 CCM00343.1 - 0.045 13.6 1.6 0.11 12.4 1.6 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CCM00343.1 - 0.13 12.0 0.2 0.23 11.2 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Pkinase PF00069.25 CCM00344.1 - 6.8e-40 137.1 0.0 5.6e-21 75.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00344.1 - 1.7e-09 37.4 0.0 6.9e-07 28.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM00344.1 - 0.0019 17.0 2.1 0.002 17.0 0.3 1.8 2 1 0 2 2 2 1 Fungal protein kinase Rieske PF00355.26 CCM00345.1 - 9e-12 44.8 0.0 1.5e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 CCM00345.1 - 8.6e-10 39.0 0.3 8.6e-10 39.0 0.3 2.3 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region SUKH-4 PF14435.6 CCM00345.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 SUKH-4 immunity protein GDPD PF03009.17 CCM00346.1 - 6.3e-31 108.0 0.0 7.8e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 CCM00346.1 - 0.002 18.5 0.2 0.17 12.4 0.1 2.6 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Arabinose_Isome PF02610.15 CCM00346.1 - 0.057 12.6 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 L-arabinose isomerase bZIP_2 PF07716.15 CCM00347.1 - 1.2e-09 38.1 7.8 2.5e-09 37.1 7.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Shugoshin_N PF07558.11 CCM00347.1 - 0.00033 20.4 0.2 0.00065 19.5 0.2 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region CCDC85 PF10226.9 CCM00347.1 - 0.00049 19.8 0.3 0.00076 19.2 0.3 1.3 1 0 0 1 1 1 1 CCDC85 family bZIP_1 PF00170.21 CCM00347.1 - 0.0007 19.6 6.8 0.0053 16.8 6.8 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 CCM00347.1 - 0.022 15.2 1.3 0.047 14.2 1.3 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor TSC22 PF01166.18 CCM00347.1 - 0.092 13.1 0.3 0.22 11.8 0.3 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF2205 PF10224.9 CCM00347.1 - 0.11 12.5 0.4 0.23 11.5 0.4 1.5 1 0 0 1 1 1 0 Short coiled-coil protein NPL4 PF05021.15 CCM00348.1 - 7.1e-103 344.2 0.0 8.6e-103 343.9 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 CCM00348.1 - 1.2e-45 155.2 0.1 1.9e-45 154.6 0.1 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region PIF1 PF05970.14 CCM00349.1 - 7e-53 180.1 0.1 5.8e-19 68.5 0.0 3.1 2 1 1 3 3 3 3 PIF1-like helicase Cauli_VI PF01693.16 CCM00349.1 - 3e-18 65.8 1.1 6.2e-18 64.8 1.1 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin AAA_30 PF13604.6 CCM00349.1 - 5.9e-14 52.2 0.0 3.2e-13 49.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM00349.1 - 1.1e-07 32.3 0.0 3.1e-07 30.8 0.0 1.9 2 1 0 2 2 1 1 AAA domain UvrD_C_2 PF13538.6 CCM00349.1 - 0.00061 19.6 0.1 0.0019 18.0 0.1 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 CCM00349.1 - 0.00067 20.1 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CCM00349.1 - 0.001 18.6 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Herpes_Helicase PF02689.14 CCM00349.1 - 0.0036 15.3 0.8 0.005 14.8 0.1 1.5 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.6 CCM00349.1 - 0.0057 16.9 0.2 0.024 14.9 0.2 1.9 1 1 0 1 1 1 1 AAA domain SH3_13 PF18335.1 CCM00349.1 - 0.011 15.5 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain Viral_helicase1 PF01443.18 CCM00349.1 - 0.011 15.4 2.3 3.1 7.5 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 CCM00349.1 - 0.013 15.0 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 CCM00349.1 - 0.016 15.7 0.1 0.053 14.0 0.0 2.0 2 0 0 2 2 2 0 ABC transporter NB-ARC PF00931.22 CCM00349.1 - 0.1 11.7 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain TrwB_AAD_bind PF10412.9 CCM00349.1 - 0.11 11.3 0.1 0.18 10.7 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF2075 PF09848.9 CCM00349.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 CCM00349.1 - 0.14 12.1 0.0 0.42 10.5 0.0 1.9 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 CCM00349.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 CCM00349.1 - 0.17 11.0 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 CCM00349.1 - 0.32 10.7 1.2 26 4.5 0.2 2.8 2 1 1 3 3 3 0 AAA domain Pkinase PF00069.25 CCM00350.1 - 0.022 14.1 0.0 0.026 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain RhoGAP PF00620.27 CCM00351.1 - 5.5e-43 146.4 0.3 1.1e-42 145.4 0.3 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 CCM00351.1 - 8.4e-06 26.0 0.0 2.5e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Rad51 PF08423.11 CCM00352.1 - 1.7e-122 407.6 0.0 2.1e-122 407.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 CCM00352.1 - 9.5e-11 41.6 0.0 1.3e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 CCM00352.1 - 2.7e-10 40.2 0.0 3.9e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 CCM00352.1 - 3.4e-08 34.0 0.9 1.1e-07 32.3 0.5 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 CCM00352.1 - 2.5e-05 23.8 0.0 5.7e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 KaiC HHH PF00633.23 CCM00352.1 - 0.039 13.8 0.1 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif PAXNEB PF05625.11 CCM00352.1 - 0.11 11.6 0.3 0.28 10.3 0.1 1.7 2 0 0 2 2 2 0 PAXNEB protein 2-Hacid_dh_C PF02826.19 CCM00353.1 - 2.7e-51 173.4 0.0 8.9e-51 171.8 0.0 1.9 2 1 1 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM00353.1 - 3.6e-34 117.3 0.0 5.1e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCM00353.1 - 0.0031 17.7 0.1 0.018 15.2 0.0 2.1 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 CCM00353.1 - 0.0058 15.9 0.0 0.017 14.4 0.0 2.0 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.21 CCM00353.1 - 0.0099 16.0 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 CCM00353.1 - 0.054 14.0 0.0 0.16 12.5 0.0 1.8 1 0 0 1 1 1 0 XdhC Rossmann domain Oxidored_nitro PF00148.19 CCM00353.1 - 0.11 11.3 0.0 0.19 10.4 0.0 1.4 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase His_biosynth PF00977.21 CCM00354.1 - 3.9e-46 157.4 0.7 1.9e-29 102.8 0.2 2.6 2 1 0 2 2 2 2 Histidine biosynthesis protein GATase PF00117.28 CCM00354.1 - 4.8e-21 75.4 0.0 8.9e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 CCM00354.1 - 8.4e-07 28.8 0.0 1.7e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 CCM00354.1 - 7.5e-06 25.9 0.0 0.00091 19.1 0.0 2.4 2 0 0 2 2 2 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 CCM00354.1 - 0.009 15.8 0.3 0.3 10.8 0.0 2.2 2 0 0 2 2 2 1 Peptidase C26 Agenet PF05641.12 CCM00354.1 - 0.055 14.0 0.2 0.23 11.9 0.2 2.0 1 0 0 1 1 1 0 Agenet domain Salt_tol_Pase PF09506.10 CCM00354.1 - 0.13 11.0 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) Pal1 PF08316.11 CCM00355.1 - 1.6e-15 58.0 1.7 4e-15 56.8 0.3 2.4 2 1 0 2 2 2 1 Pal1 cell morphology protein Dak1 PF02733.17 CCM00356.1 - 3.7e-93 311.8 1.4 2.1e-45 155.0 0.9 3.2 3 0 0 3 3 3 3 Dak1 domain Dak2 PF02734.17 CCM00356.1 - 8.3e-36 123.5 5.1 3.9e-23 82.2 0.3 2.3 2 0 0 2 2 2 2 DAK2 domain UCH PF00443.29 CCM00357.1 - 2.7e-71 240.1 0.0 4e-71 239.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 CCM00357.1 - 4.6e-13 49.6 1.5 1.2e-12 48.3 1.0 2.1 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 CCM00357.1 - 1.4e-12 47.9 0.0 6e-05 22.8 0.0 3.3 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUF1712 PF08217.11 CCM00358.1 - 4.9e-19 68.2 0.0 6.8e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Tim17 PF02466.19 CCM00359.1 - 9.8e-26 90.3 5.9 1.2e-25 90.0 5.9 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF1688 PF07958.11 CCM00360.1 - 3.6e-176 586.0 0.0 4.3e-176 585.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Cytochrom_C1 PF02167.15 CCM00362.1 - 3.8e-98 327.6 0.0 4.6e-98 327.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 CCM00362.1 - 0.002 18.4 0.0 0.0041 17.4 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CCM00362.1 - 0.016 16.3 0.0 0.057 14.6 0.0 1.9 2 0 0 2 2 2 0 Cytochrome c SAC3_GANP PF03399.16 CCM00363.1 - 2.2e-22 79.8 2.6 3.7e-20 72.5 2.6 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CCM00363.1 - 5.6e-07 29.6 0.6 3.7e-06 27.0 0.0 2.5 4 0 0 4 4 4 1 CSN8/PSMD8/EIF3K family tRNA_int_endo PF01974.17 CCM00364.1 - 2.2e-12 46.9 0.2 5e-12 45.7 0.2 1.6 1 1 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 CCM00364.1 - 0.0011 18.6 0.0 0.011 15.4 0.0 2.2 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Nop25 PF09805.9 CCM00364.1 - 0.035 14.6 2.3 0.053 14.0 2.3 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) NHase_beta PF02211.15 CCM00364.1 - 0.11 12.5 0.1 0.16 12.0 0.1 1.2 1 0 0 1 1 1 0 Nitrile hydratase beta subunit WD40 PF00400.32 CCM00365.1 - 3.6e-09 37.1 10.3 0.082 13.8 0.1 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat AAA_11 PF13086.6 CCM00365.1 - 0.051 13.4 0.4 0.09 12.5 0.4 1.3 1 0 0 1 1 1 0 AAA domain C2-C2_1 PF11618.8 CCM00365.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 First C2 domain of RPGR-interacting protein 1 Dynein_IC2 PF11540.8 CCM00365.1 - 0.16 12.0 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Cytoplasmic dynein 1 intermediate chain 2 HAND PF09110.11 CCM00365.1 - 0.98 10.2 10.8 2.3 9.0 10.8 1.5 1 0 0 1 1 1 0 HAND FadA PF09403.10 CCM00365.1 - 8.5 6.9 18.0 22 5.6 8.4 3.2 2 1 1 3 3 3 0 Adhesion protein FadA Aminotran_5 PF00266.19 CCM00366.1 - 2.2e-22 79.5 0.0 2.3e-21 76.2 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V RRM_DME PF15628.6 CCM00366.1 - 0.011 15.9 0.0 0.031 14.4 0.0 1.8 1 0 0 1 1 1 0 RRM in Demeter NIR_SIR PF01077.22 CCM00367.1 - 5.5e-53 178.7 0.1 2.9e-47 160.1 0.1 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CCM00367.1 - 2.8e-32 110.4 0.0 4e-15 55.4 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 CCM00367.1 - 1.2e-28 100.2 0.0 2.8e-28 98.9 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 CCM00367.1 - 0.077 12.7 0.2 0.16 11.7 0.2 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Ribosomal_L7Ae PF01248.26 CCM00368.1 - 3.2e-22 78.1 0.0 3.8e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Actin PF00022.19 CCM00369.1 - 2.5e-30 105.4 0.0 4.3e-22 78.3 0.0 2.1 2 0 0 2 2 2 2 Actin MDMPI_N PF11716.8 CCM00369.1 - 0.15 12.8 5.1 0.12 13.1 1.7 2.4 2 1 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain SQHop_cyclase_N PF13249.6 CCM00370.1 - 4.2e-52 177.1 0.1 8.7e-42 143.2 0.0 3.7 3 1 1 4 4 4 3 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 CCM00370.1 - 1.8e-42 145.6 0.2 1.7e-38 132.5 0.8 3.2 2 1 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 CCM00370.1 - 8.1e-33 111.9 10.3 4.2e-10 39.2 0.3 6.4 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 CCM00370.1 - 0.022 14.1 0.9 8.4 5.6 0.0 3.2 2 1 1 3 3 3 0 Pectic acid lyase PMM PF03332.13 CCM00372.1 - 8.6e-104 346.1 0.6 1e-103 345.9 0.6 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase HAD PF12710.7 CCM00372.1 - 0.0028 18.1 0.0 1.8 9.0 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CCM00372.1 - 0.0034 17.0 0.0 0.045 13.3 0.0 2.0 1 1 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 CCM00372.1 - 0.013 15.3 0.0 0.055 13.2 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase bVLRF1 PF18826.1 CCM00373.1 - 8.7e-66 220.4 0.0 2e-65 219.2 0.0 1.7 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_4 PF13637.6 CCM00373.1 - 0.0052 17.3 0.0 0.01 16.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM00373.1 - 0.02 15.4 0.0 0.05 14.2 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat Ank_5 PF13857.6 CCM00373.1 - 0.052 13.9 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM00373.1 - 0.082 13.5 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) DNA_pol_B PF00136.21 CCM00374.1 - 2.4e-147 491.3 0.4 3.5e-147 490.8 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CCM00374.1 - 2.8e-75 253.6 0.0 2.5e-74 250.4 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CCM00374.1 - 8.1e-18 64.7 7.7 1.9e-17 63.5 7.7 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 CCM00374.1 - 0.00084 18.3 0.7 0.0035 16.3 0.1 2.0 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 CCM00374.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DUF1476 PF07345.11 CCM00374.1 - 0.035 14.5 0.4 12 6.3 0.0 2.5 2 0 0 2 2 2 0 ATPase inhibitor subunit zeta C1_1 PF00130.22 CCM00374.1 - 3.1 7.8 8.4 16 5.5 0.5 2.6 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TRAUB PF08164.12 CCM00375.1 - 2.2e-28 98.6 0.6 8e-28 96.8 0.0 2.4 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 CCM00375.1 - 1.1e-26 94.2 0.7 1.1e-26 94.2 0.7 2.8 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor Phage_tail_APC PF16778.5 CCM00375.1 - 0.071 13.0 0.6 0.4 10.6 0.4 2.5 1 1 0 1 1 1 0 Phage tail assembly chaperone protein AT_hook PF02178.19 CCM00376.1 - 0.12 12.3 2.0 0.53 10.3 2.0 2.2 1 0 0 1 1 1 0 AT hook motif TFIIA PF03153.13 CCM00376.1 - 1.8 8.5 9.5 0.65 9.9 2.8 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PX PF00787.24 CCM00377.1 - 3.8e-22 78.4 0.7 2.3e-21 75.9 0.0 2.5 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 CCM00377.1 - 0.0065 16.0 3.2 0.0065 16.0 3.2 2.1 2 0 0 2 2 2 1 Vps5 C terminal like Sec8_exocyst PF04048.14 CCM00377.1 - 0.086 12.7 7.4 2.8 7.8 0.4 2.7 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain MCU PF04678.13 CCM00377.1 - 0.11 12.5 2.2 3.5 7.7 2.3 2.4 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF4391 PF14335.6 CCM00377.1 - 0.18 11.5 6.0 0.036 13.8 1.3 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4391) AAA_23 PF13476.6 CCM00377.1 - 0.31 11.5 7.5 0.19 12.2 3.4 2.1 2 0 0 2 2 2 0 AAA domain FliD_N PF02465.18 CCM00377.1 - 1.6 9.5 6.8 0.67 10.7 1.8 2.8 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus DUF3450 PF11932.8 CCM00377.1 - 2.1 7.6 12.1 0.4 9.9 6.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) FapA PF03961.13 CCM00377.1 - 6.4 5.3 6.6 0.46 9.0 1.7 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A GAS PF13851.6 CCM00378.1 - 0.0081 15.5 13.4 0.029 13.7 7.6 2.1 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding FH2 PF02181.23 CCM00378.1 - 0.019 14.1 7.3 0.19 10.8 0.1 2.1 2 0 0 2 2 2 0 Formin Homology 2 Domain DUF5339 PF17274.2 CCM00378.1 - 0.035 14.9 4.7 4 8.4 0.1 2.7 3 0 0 3 3 2 0 Family of unknown function (DUF5339) DUF5098 PF17023.5 CCM00378.1 - 0.16 10.9 1.7 0.28 10.1 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) TPR_MLP1_2 PF07926.12 CCM00378.1 - 0.16 12.1 15.1 0.71 9.9 8.0 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 CCM00378.1 - 0.17 11.6 13.1 0.51 10.1 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) MscS_porin PF12795.7 CCM00378.1 - 0.19 11.2 11.7 12 5.3 0.0 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Spc7 PF08317.11 CCM00378.1 - 0.27 10.1 13.6 0.41 9.5 0.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein APG17 PF04108.12 CCM00378.1 - 0.38 9.8 8.2 2.1 7.4 4.4 2.1 2 0 0 2 2 2 0 Autophagy protein Apg17 Spore_III_AB PF09548.10 CCM00378.1 - 0.48 10.5 3.7 0.68 10.0 1.6 1.9 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF4423 PF14394.6 CCM00378.1 - 0.59 9.8 4.5 6.9 6.4 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4423) DUF4600 PF15372.6 CCM00378.1 - 0.91 10.0 8.5 1.9 9.0 3.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4600) Golgin_A5 PF09787.9 CCM00378.1 - 1.2 8.5 13.4 1.5 8.2 7.0 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 ATG16 PF08614.11 CCM00378.1 - 1.4 9.1 13.5 6.6 6.9 9.7 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Fmp27_WPPW PF10359.9 CCM00378.1 - 2.1 7.1 5.7 1.9 7.2 1.2 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Jnk-SapK_ap_N PF09744.9 CCM00378.1 - 3.5 7.8 14.1 0.73 10.0 7.1 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 RF-1 PF00472.20 CCM00378.1 - 5.2 7.0 11.8 4 7.4 1.8 3.1 2 1 1 3 3 3 0 RF-1 domain DUF4140 PF13600.6 CCM00378.1 - 5.9 7.4 12.5 6.5 7.3 0.2 3.3 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) CENP-F_leu_zip PF10473.9 CCM00378.1 - 6.6 6.8 17.9 1.8 8.6 9.4 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 CCM00378.1 - 8.6 6.4 7.9 14 5.7 3.5 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) PRKG1_interact PF15898.5 CCM00378.1 - 9.2 7.2 14.6 12 6.9 0.3 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain HisKA PF00512.25 CCM00378.1 - 9.5 6.3 9.5 0.99 9.5 1.1 2.8 2 1 1 3 3 3 0 His Kinase A (phospho-acceptor) domain DUF1771 PF08590.10 CCM00379.1 - 8.5e-15 54.9 8.9 1.9e-14 53.8 8.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) zf_CCCH_4 PF18345.1 CCM00379.1 - 2.3e-09 37.0 9.3 2.1e-07 30.7 1.9 2.9 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 CCM00379.1 - 9.3e-09 35.0 7.7 3e-06 27.0 0.9 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCM00379.1 - 1.1e-07 32.5 3.7 1.2e-06 29.1 0.1 2.3 1 1 1 2 2 2 1 Torus domain zf-CCCH_4 PF18044.1 CCM00379.1 - 2.5e-06 27.1 13.3 0.00013 21.7 1.5 3.3 2 1 0 2 2 2 2 CCCH-type zinc finger Smr PF01713.21 CCM00379.1 - 1e-05 25.8 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Smr domain zf-CCCH_2 PF14608.6 CCM00379.1 - 0.0003 21.1 6.5 0.12 12.9 0.9 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 CCM00379.1 - 0.0012 19.1 2.9 0.59 10.4 0.2 2.3 1 1 1 2 2 2 2 Zinc-finger containing family zf-C3H1 PF10650.9 CCM00379.1 - 0.0012 18.5 4.2 0.094 12.5 0.5 2.4 2 0 0 2 2 2 2 Putative zinc-finger domain HBS1_N PF08938.10 CCM00379.1 - 0.22 11.8 0.4 0.61 10.4 0.0 1.9 2 0 0 2 2 2 0 HBS1 N-terminus Fungal_trans PF04082.18 CCM00380.1 - 2.3e-12 46.5 0.8 3.7e-12 45.8 0.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cation_efflux PF01545.21 CCM00381.1 - 1.1e-42 146.0 17.6 1.1e-42 146.0 17.6 2.9 2 2 0 2 2 2 1 Cation efflux family Rcd1 PF04078.13 CCM00382.1 - 1.5e-124 414.5 4.3 1.7e-124 414.3 4.3 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like PH PF00169.29 CCM00383.1 - 8.8e-07 29.4 0.0 2.4e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 PH domain Macoilin PF09726.9 CCM00383.1 - 0.0016 17.1 18.1 0.0023 16.6 18.1 1.2 1 0 0 1 1 1 1 Macoilin family TFIIA PF03153.13 CCM00383.1 - 6.4 6.7 15.1 7.7 6.4 15.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PDCD2_C PF04194.13 CCM00384.1 - 1.2e-44 152.5 0.0 1.2e-44 152.5 0.0 2.1 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain Fungal_trans PF04082.18 CCM00385.1 - 3.7e-20 72.1 0.4 7.4e-20 71.1 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CtIP_N PF10482.9 CCM00385.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Ras PF00071.22 CCM00386.1 - 8.6e-36 123.0 0.0 9.7e-36 122.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM00386.1 - 4.3e-19 68.9 0.0 1.4e-18 67.2 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM00386.1 - 1.8e-05 24.3 0.0 2.9e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCM00386.1 - 0.0013 18.2 0.0 0.0016 17.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCM00386.1 - 0.01 15.9 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF2829 PF11195.8 CCM00386.1 - 0.081 13.2 0.1 0.18 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2829) Skp1_POZ PF03931.15 CCM00386.1 - 0.085 13.0 0.1 0.22 11.7 0.1 1.7 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Gtr1_RagA PF04670.12 CCM00386.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Clathrin PF00637.20 CCM00387.1 - 8.9e-206 674.1 25.5 2e-34 118.5 0.3 7.8 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 CCM00387.1 - 3.8e-36 121.6 0.2 1.1e-06 28.7 0.1 6.8 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin_H_link PF13838.6 CCM00387.1 - 3.9e-31 106.8 0.1 1.7e-30 104.7 0.1 2.2 1 0 0 1 1 1 1 Clathrin-H-link Clathrin-link PF09268.10 CCM00387.1 - 1.3e-11 43.6 0.2 6.2e-11 41.5 0.1 2.3 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 CCM00387.1 - 0.00076 18.6 4.3 2 7.4 0.0 4.2 4 0 0 4 4 4 2 Coatomer WD associated region TPR_2 PF07719.17 CCM00387.1 - 0.0009 19.2 6.8 13 6.2 0.1 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCM00387.1 - 0.0017 19.0 13.1 5.4 8.1 0.0 8.7 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCM00387.1 - 0.027 14.3 6.6 15 5.6 0.2 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCM00387.1 - 0.039 14.0 8.0 4.8 7.4 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Acetyltransf_15 PF17013.5 CCM00387.1 - 0.059 12.8 0.6 0.22 11.0 0.0 2.3 3 0 0 3 3 3 0 Putative acetyl-transferase Nucleoporin_N PF08801.11 CCM00387.1 - 0.12 11.0 0.5 0.33 9.6 0.0 1.9 2 1 0 2 2 2 0 Nup133 N terminal like TPR_8 PF13181.6 CCM00387.1 - 0.51 10.7 7.4 7.8 7.0 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat DEAD PF00270.29 CCM00388.1 - 5.6e-40 137.0 0.0 1.4e-39 135.7 0.0 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 CCM00388.1 - 4.1e-25 87.8 0.9 9.3e-24 83.4 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 CCM00388.1 - 9.2e-19 67.8 0.0 2.6e-18 66.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM00388.1 - 6.6e-05 23.0 0.0 0.00024 21.1 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T4SS-DNA_transf PF02534.14 CCM00388.1 - 0.063 12.1 1.1 6.3 5.5 0.0 2.2 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer AAA_22 PF13401.6 CCM00388.1 - 0.094 13.0 0.0 0.67 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain PH_13 PF16652.5 CCM00388.1 - 8.1 6.2 9.4 16 5.3 9.4 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain SDH_alpha PF03313.15 CCM00389.1 - 6e-93 311.3 3.3 7.3e-93 311.0 3.3 1.1 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 CCM00389.1 - 3.8e-12 46.9 0.0 9.9e-12 45.5 0.0 1.8 1 0 0 1 1 1 1 Serine dehydratase beta chain EamA PF00892.20 CCM00390.1 - 0.00016 21.8 4.1 0.00016 21.8 4.1 3.0 2 1 0 2 2 2 1 EamA-like transporter family CPSase_L_D2 PF02786.17 CCM00391.1 - 1.3e-79 266.6 0.1 2.7e-79 265.6 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 CCM00391.1 - 5.7e-69 231.8 0.0 9.5e-69 231.1 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 CCM00391.1 - 3.3e-36 124.2 0.1 7.3e-36 123.1 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain HMGL-like PF00682.19 CCM00391.1 - 3.5e-27 95.6 0.0 7.5e-27 94.5 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Biotin_carb_C PF02785.19 CCM00391.1 - 2.7e-26 91.8 0.0 1.1e-25 89.9 0.0 2.1 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCM00391.1 - 1.5e-12 47.2 3.7 6.2e-12 45.2 3.7 2.2 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CCM00391.1 - 1.2e-09 38.0 0.0 2.5e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CCM00391.1 - 4.3e-09 36.1 4.8 0.00054 19.7 0.3 2.8 3 0 0 3 3 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 CCM00391.1 - 2e-07 30.8 0.0 4.2e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 CCM00391.1 - 1.6e-06 28.3 0.0 3.5e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 CCM00391.1 - 0.00019 22.1 1.6 1.1 10.0 0.2 3.3 2 1 1 3 3 2 2 HlyD family secretion protein ATP-grasp_4 PF13535.6 CCM00391.1 - 0.00047 19.8 0.0 0.001 18.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 CCM00391.1 - 0.00048 19.4 0.7 0.019 14.2 0.1 2.4 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion GARS_A PF01071.19 CCM00391.1 - 0.0018 18.1 0.0 0.004 16.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 CCM00391.1 - 0.0088 15.3 0.0 0.05 12.9 0.0 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Peptidase_M23 PF01551.22 CCM00391.1 - 0.0098 16.1 0.2 0.049 13.8 0.2 2.2 1 0 0 1 1 1 1 Peptidase family M23 NQRA PF05896.11 CCM00391.1 - 0.057 12.8 0.3 0.21 11.0 0.4 1.9 2 0 0 2 2 2 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) GCV_H PF01597.19 CCM00391.1 - 0.12 12.3 2.1 0.49 10.3 0.4 2.8 2 1 1 3 3 3 0 Glycine cleavage H-protein DUF1772 PF08592.11 CCM00392.1 - 0.071 13.4 0.9 0.87 9.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) eIF-3c_N PF05470.12 CCM00393.1 - 1.1e-185 618.4 19.9 1.1e-185 618.4 19.9 2.5 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 CCM00393.1 - 3.9e-15 56.2 0.2 2.2e-14 53.8 0.0 2.4 2 1 0 2 2 2 1 PCI domain SmpB PF01668.18 CCM00393.1 - 0.029 14.2 0.3 0.32 10.9 0.0 2.5 2 0 0 2 2 2 0 SmpB protein PhaC_N PF07167.13 CCM00393.1 - 0.088 12.4 0.5 1 9.0 0.4 2.2 2 0 0 2 2 2 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus DUF2408 PF10303.9 CCM00393.1 - 1.1 9.8 8.0 1.1 9.8 0.4 3.7 3 2 0 3 3 3 0 Protein of unknown function (DUF2408) Hexapep PF00132.24 CCM00394.1 - 1.2e-08 34.3 3.6 0.0012 18.5 0.7 3.3 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CCM00394.1 - 3.2e-05 24.3 0.0 5.4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 CCM00394.1 - 0.0025 16.0 1.9 0.0038 15.4 1.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 CCM00394.1 - 1 9.2 5.2 0.89 9.4 2.5 2.1 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase Pkinase PF00069.25 CCM00395.1 - 4.2e-65 219.7 0.0 5.4e-65 219.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00395.1 - 3.3e-48 164.2 0.0 4.7e-48 163.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM00395.1 - 8.3e-05 22.0 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCM00395.1 - 0.00016 20.6 0.0 0.00031 19.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCM00395.1 - 0.00099 19.1 0.0 0.35 10.8 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 CCM00395.1 - 0.035 13.7 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 CCM00395.1 - 0.036 13.0 0.0 0.036 13.0 0.0 1.9 3 0 0 3 3 3 0 Haspin like kinase domain Kdo PF06293.14 CCM00395.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APS_kinase PF01583.20 CCM00396.1 - 3.5e-72 241.4 0.0 4.2e-72 241.2 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CCM00396.1 - 1.1e-06 28.9 0.0 1.7e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCM00396.1 - 1.5e-05 25.5 0.0 2.1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCM00396.1 - 0.0026 17.5 0.1 0.0043 16.8 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain KTI12 PF08433.10 CCM00396.1 - 0.0029 17.1 0.0 0.0035 16.8 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 CPT PF07931.12 CCM00396.1 - 0.042 13.7 0.3 0.31 10.9 0.3 2.1 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 CCM00396.1 - 0.081 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin G-alpha PF00503.20 CCM00396.1 - 0.11 11.7 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Peptidase_C15 PF01470.17 CCM00397.1 - 0.00013 22.2 0.1 0.0016 18.6 0.0 2.5 3 0 0 3 3 3 1 Pyroglutamyl peptidase TAFH PF07531.14 CCM00397.1 - 0.075 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 NHR1 homology to TAF Peptidase_C15 PF01470.17 CCM00398.1 - 2.3e-10 41.0 0.1 0.00015 22.0 0.0 2.5 1 1 1 2 2 2 2 Pyroglutamyl peptidase MgsA_C PF12002.8 CCM00399.1 - 3.6e-54 183.2 0.1 5e-54 182.7 0.1 1.2 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 CCM00399.1 - 1.4e-17 63.8 0.1 3.8e-17 62.4 0.0 1.8 2 0 0 2 2 1 1 AAA C-terminal domain AAA PF00004.29 CCM00399.1 - 1.2e-07 32.2 0.1 3.6e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCM00399.1 - 4.5e-07 29.7 0.0 6.9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCM00399.1 - 0.0004 20.8 0.0 0.00076 19.9 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CCM00399.1 - 0.0011 19.2 0.0 0.0024 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCM00399.1 - 0.0014 18.9 0.0 0.0053 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CCM00399.1 - 0.0025 17.8 0.0 0.0049 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CCM00399.1 - 0.003 17.5 0.0 0.005 16.8 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 CCM00399.1 - 0.0041 17.7 0.0 0.008 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CCM00399.1 - 0.01 16.1 0.1 0.032 14.5 0.1 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCM00399.1 - 0.011 16.1 0.0 0.047 14.1 0.0 2.1 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 CCM00399.1 - 0.015 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 CCM00399.1 - 0.026 15.0 0.0 0.065 13.8 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CCM00399.1 - 0.089 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 CCM00399.1 - 0.096 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase SET PF00856.28 CCM00400.1 - 2.1e-19 70.5 0.2 6.4e-19 69.0 0.2 1.9 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.16 CCM00400.1 - 3.1e-17 63.2 1.9 3.1e-17 63.2 1.9 2.0 2 0 0 2 2 2 1 Pre-SET motif AWS PF17907.1 CCM00400.1 - 0.072 13.1 2.2 0.25 11.4 2.2 1.9 1 0 0 1 1 1 0 AWS domain zf-C2H2_2 PF12756.7 CCM00401.1 - 1.9e-28 98.8 0.0 3.4e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCM00401.1 - 0.0081 16.9 1.0 8.8 7.5 0.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger ARS2 PF04959.13 CCM00401.1 - 0.79 10.1 3.3 1 9.7 0.0 2.3 2 1 0 2 2 2 0 Arsenite-resistance protein 2 Rax2 PF12768.7 CCM00402.1 - 1.8e-43 148.5 6.9 5.4e-41 140.4 0.4 4.3 4 0 0 4 4 4 2 Cortical protein marker for cell polarity SH3_1 PF00018.28 CCM00402.1 - 0.02 14.5 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 SH3 domain Reg_prop PF07494.11 CCM00402.1 - 0.091 13.0 0.7 10 6.7 0.0 4.3 3 0 0 3 3 3 0 Two component regulator propeller Kelch_2 PF07646.15 CCM00402.1 - 0.1 12.6 0.5 3.4 7.8 0.0 3.8 5 0 0 5 5 5 0 Kelch motif Rhomboid PF01694.22 CCM00402.1 - 0.69 9.9 11.8 0.22 11.5 0.5 2.9 3 0 0 3 3 3 0 Rhomboid family Dioxygenase_C PF00775.21 CCM00403.1 - 2.2e-42 144.6 0.0 3.6e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CCM00403.1 - 1.9e-25 88.5 0.0 3.1e-25 87.8 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 CCM00403.1 - 0.18 12.1 0.3 0.49 10.7 0.3 1.7 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain RPEL PF02755.15 CCM00405.1 - 5.7e-17 60.8 13.7 1.3e-09 37.4 3.3 3.1 3 0 0 3 3 3 2 RPEL repeat DUF1279 PF06916.13 CCM00406.1 - 8.6e-15 55.1 0.0 1.5e-14 54.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) SAM_decarbox PF01536.16 CCM00407.1 - 3.2e-116 388.2 0.0 4.1e-116 387.9 0.0 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Zn_clus PF00172.18 CCM00408.1 - 1.5e-09 37.8 28.5 9.5e-05 22.4 13.7 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain EndIII_4Fe-2S PF10576.9 CCM00408.1 - 0.12 12.7 4.4 2.8 8.4 0.5 3.2 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III Dfp1_Him1_M PF08630.10 CCM00409.1 - 4.6e-29 101.2 0.1 1.2e-28 99.9 0.0 1.7 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 CCM00409.1 - 2.3e-18 66.0 0.1 3.7e-18 65.4 0.1 1.3 1 0 0 1 1 1 1 DBF zinc finger PTCB-BRCT PF12738.7 CCM00409.1 - 0.0045 16.9 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain DUF1045 PF06299.12 CCM00409.1 - 0.37 10.7 3.6 12 5.8 3.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1045) GCP_C_terminal PF04130.13 CCM00410.1 - 1.3e-56 192.4 0.0 3.9e-56 190.8 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CCM00410.1 - 3.8e-05 23.5 0.0 8.1e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal AAA_22 PF13401.6 CCM00411.1 - 3.6e-13 50.0 0.1 6.5e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCM00411.1 - 7.1e-10 39.5 0.1 2.5e-08 34.5 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CCM00411.1 - 7.9e-09 36.0 0.1 2e-08 34.7 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CCM00411.1 - 4.4e-05 23.4 0.1 8.1e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.6 CCM00411.1 - 7.2e-05 22.6 0.3 0.00016 21.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCM00411.1 - 0.0012 19.2 0.0 0.0025 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CCM00411.1 - 0.0016 18.4 0.0 0.0028 17.6 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TniB PF05621.11 CCM00411.1 - 0.0017 17.8 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein DUF2075 PF09848.9 CCM00411.1 - 0.0025 17.1 0.0 0.0039 16.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.14 CCM00411.1 - 0.0031 16.8 2.2 0.48 9.6 0.2 2.7 2 1 1 3 3 3 2 KAP family P-loop domain NB-ARC PF00931.22 CCM00411.1 - 0.0037 16.5 0.1 0.0056 15.9 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_5 PF07728.14 CCM00411.1 - 0.006 16.6 0.1 0.034 14.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_35 PF14516.6 CCM00411.1 - 0.0084 15.0 0.1 0.013 14.4 0.1 1.2 1 0 0 1 1 1 1 AAA-like domain NTPase_1 PF03266.15 CCM00411.1 - 0.028 14.3 0.0 0.1 12.5 0.0 1.9 1 1 0 1 1 1 0 NTPase Helicase_RecD PF05127.14 CCM00411.1 - 0.037 13.9 0.0 0.068 13.0 0.0 1.5 1 0 0 1 1 1 0 Helicase cobW PF02492.19 CCM00411.1 - 0.047 13.3 0.0 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 CCM00411.1 - 0.07 13.5 0.1 0.42 11.0 0.1 2.1 1 1 0 1 1 1 0 RNA helicase TrwB_AAD_bind PF10412.9 CCM00411.1 - 0.082 11.8 0.0 0.2 10.5 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Cdc6_C PF09079.11 CCM00411.1 - 0.15 12.1 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain AAA_7 PF12775.7 CCM00411.1 - 0.18 11.3 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TP6A_N PF04406.14 CCM00412.1 - 1.1e-20 73.3 0.1 3.5e-20 71.7 0.0 1.9 2 0 0 2 2 2 1 Type IIB DNA topoisomerase BTB PF00651.31 CCM00413.1 - 0.0039 17.4 0.0 0.0084 16.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain MutS_III PF05192.18 CCM00414.1 - 0.088 13.0 0.1 0.14 12.3 0.1 1.3 1 1 0 1 1 1 0 MutS domain III DUF3435 PF11917.8 CCM00414.1 - 0.32 9.9 3.3 0.48 9.3 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) COG2 PF06148.11 CCM00414.1 - 1.3 9.1 5.1 2.7 8.1 3.8 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ABC_tran_CTD PF16326.5 CCM00414.1 - 2 8.7 9.8 0.16 12.3 2.1 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain Glyco_hydro_63 PF03200.16 CCM00415.1 - 2.8e-07 29.7 14.9 3.7e-07 29.3 1.2 4.5 5 1 0 5 5 5 2 Glycosyl hydrolase family 63 C-terminal domain RhoGAP PF00620.27 CCM00416.1 - 1.2e-31 109.6 0.0 2.2e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Mito_carr PF00153.27 CCM00417.1 - 1.7e-44 149.6 1.4 7.6e-24 83.5 0.1 3.0 3 0 0 3 3 3 2 Mitochondrial carrier protein PH_10 PF15411.6 CCM00418.1 - 2.8e-38 130.9 0.0 5.3e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 CCM00418.1 - 1.2e-30 107.1 0.0 2.3e-30 106.2 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 CCM00418.1 - 9.7e-18 63.9 0.0 1.9e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 PB1 domain CDC24 PF06395.11 CCM00418.1 - 1.4e-11 44.5 0.0 2.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 CDC24 Calponin BRCT_2 PF16589.5 CCM00419.1 - 7.7e-09 35.9 0.0 2e-08 34.5 0.0 1.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-bind_2 PF08914.11 CCM00419.1 - 5.4e-05 23.3 7.3 0.025 14.8 0.2 3.4 3 0 0 3 3 3 2 Rap1 Myb domain BRCT PF00533.26 CCM00419.1 - 0.0035 17.7 0.0 0.0065 16.8 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rap1-DNA-bind PF09197.10 CCM00419.1 - 4.8 7.8 11.9 23 5.6 2.1 3.6 1 1 2 3 3 3 0 Rap1, DNA-binding PhyH PF05721.13 CCM00420.1 - 6.4e-46 157.3 0.0 7.9e-46 157.0 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HK PF02110.15 CCM00421.1 - 6.6e-72 241.8 2.0 7.9e-70 235.0 2.0 2.2 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 CCM00421.1 - 4.9e-21 74.9 0.1 8.8e-21 74.0 0.1 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 CCM00421.1 - 0.002 17.5 0.0 0.0048 16.3 0.0 1.6 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase SUR7 PF06687.12 CCM00424.1 - 1.7e-07 31.1 17.2 3.3e-06 26.9 17.1 2.1 1 1 0 1 1 1 1 SUR7/PalI family DUF456 PF04306.13 CCM00424.1 - 0.00089 19.6 9.6 0.00089 19.6 9.6 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF456) DUF3188 PF11384.8 CCM00424.1 - 0.12 12.1 0.0 0.12 12.1 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3188) Amastin PF07344.11 CCM00424.1 - 0.22 11.4 8.4 0.28 11.0 8.4 1.3 1 1 0 1 1 1 0 Amastin surface glycoprotein Oxidored_q2 PF00420.24 CCM00424.1 - 1 9.1 7.9 0.093 12.4 0.7 2.6 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF373 PF04123.13 CCM00424.1 - 7.1 6.0 8.7 12 5.3 8.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF373) STIMATE PF12400.8 CCM00425.1 - 1.5e-26 93.4 2.8 1.5e-26 93.4 2.8 1.7 2 0 0 2 2 2 1 STIMATE family PGAP1 PF07819.13 CCM00426.1 - 4.8e-51 173.7 0.0 6.8e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 CCM00426.1 - 1.1e-05 26.2 1.0 4.7e-05 24.1 1.0 2.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM00426.1 - 0.006 15.9 0.2 0.021 14.1 0.1 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCM00426.1 - 0.01 15.5 0.3 0.057 13.1 0.3 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.12 CCM00426.1 - 0.018 14.6 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF676 PF05057.14 CCM00426.1 - 0.12 11.9 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) CorA PF01544.18 CCM00427.1 - 1.5e-45 155.8 0.1 2.1e-45 155.3 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 CCM00427.1 - 0.026 14.6 0.3 0.058 13.4 0.3 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2451 PF10474.9 CCM00427.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) IPP-2 PF04979.14 CCM00428.1 - 1.3e-17 64.8 4.8 3e-17 63.6 4.8 1.6 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) MAGE_N PF12440.8 CCM00428.1 - 3.4 8.4 15.0 0.068 13.8 4.4 2.9 2 1 1 3 3 3 0 Melanoma associated antigen family N terminal THF_DHG_CYH PF00763.23 CCM00429.1 - 2.5e-22 79.3 0.0 3.8e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 CCM00429.1 - 2.4e-14 53.0 0.0 4.1e-08 32.7 0.0 2.3 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_Gly3P_dh_N PF01210.23 CCM00429.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus OCD_Mu_crystall PF02423.15 CCM00429.1 - 0.19 10.7 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family ORMDL PF04061.14 CCM00430.1 - 4.9e-52 175.3 2.2 6.2e-52 175.0 2.2 1.1 1 0 0 1 1 1 1 ORMDL family VIR_N PF15912.5 CCM00431.1 - 5.3e-07 29.5 1.0 5.3e-07 29.5 1.0 2.3 2 1 0 2 2 2 1 Virilizer, N-terminal AAA PF00004.29 CCM00433.1 - 1.8e-54 183.7 0.0 8.5e-40 136.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCM00433.1 - 1.7e-11 44.6 0.0 8.4e-05 22.9 0.0 3.7 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCM00433.1 - 9.4e-11 42.4 0.1 0.00011 22.6 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 CCM00433.1 - 2.6e-09 37.2 0.0 0.0013 18.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCM00433.1 - 4.6e-09 36.2 0.1 0.0014 18.4 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 CCM00433.1 - 9.2e-09 35.0 0.0 2e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 CCM00433.1 - 1.5e-08 34.9 0.0 1.3e-05 25.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CCM00433.1 - 6.2e-08 32.9 0.0 0.0024 18.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 CCM00433.1 - 1.4e-07 31.1 0.0 0.0026 17.0 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 CCM00433.1 - 1.7e-07 30.9 0.2 0.003 17.0 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI CDC48_2 PF02933.17 CCM00433.1 - 4.2e-07 29.7 0.3 1.7e-05 24.5 0.1 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_18 PF13238.6 CCM00433.1 - 1.3e-06 29.0 0.0 0.029 14.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 CCM00433.1 - 1.3e-06 28.7 0.0 0.063 13.7 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 CCM00433.1 - 2.1e-06 27.6 0.1 0.021 14.6 0.0 2.7 2 1 0 2 2 2 2 AAA domain TsaE PF02367.17 CCM00433.1 - 3.6e-06 27.0 0.0 0.13 12.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CCM00433.1 - 8.6e-06 25.8 0.8 0.021 14.7 0.0 3.3 4 0 0 4 4 3 1 NACHT domain ABC_tran PF00005.27 CCM00433.1 - 8.8e-06 26.3 0.0 0.041 14.4 0.1 2.8 2 1 0 2 2 2 2 ABC transporter IstB_IS21 PF01695.17 CCM00433.1 - 1.7e-05 24.7 0.1 0.15 11.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.26 CCM00433.1 - 1.7e-05 24.6 0.0 0.081 12.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 CCM00433.1 - 4e-05 23.1 0.2 0.0055 16.1 0.1 2.4 2 0 0 2 2 2 1 KaiC AAA_3 PF07726.11 CCM00433.1 - 8e-05 22.5 0.0 0.11 12.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CCM00433.1 - 8.3e-05 22.4 0.0 0.51 10.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 CCM00433.1 - 0.00012 22.0 0.0 0.57 9.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CCM00433.1 - 0.00012 21.6 0.8 0.056 13.0 0.0 2.6 3 0 0 3 3 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 CCM00433.1 - 0.00023 21.5 0.3 1.1 9.6 0.1 3.2 3 0 0 3 3 3 1 AAA domain Parvo_NS1 PF01057.17 CCM00433.1 - 0.00025 20.2 0.0 0.56 9.3 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 CCM00433.1 - 0.00053 19.3 0.0 0.27 10.4 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_28 PF13521.6 CCM00433.1 - 0.00058 20.1 0.0 1.5 9.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 CCM00433.1 - 0.00062 19.7 0.2 9.5 6.0 0.0 3.8 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 CCM00433.1 - 0.00091 19.3 0.0 0.34 11.0 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 CCM00433.1 - 0.0013 18.3 2.1 2.1 7.9 0.0 3.4 3 1 1 4 4 3 2 AAA domain CDC48_N PF02359.18 CCM00433.1 - 0.0028 17.8 0.0 0.0068 16.6 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain PhoH PF02562.16 CCM00433.1 - 0.003 17.1 0.0 2.6 7.4 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein CPT PF07931.12 CCM00433.1 - 0.0033 17.3 0.1 0.05 13.5 0.0 2.3 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 CCM00433.1 - 0.0036 17.7 0.2 0.67 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 CCM00433.1 - 0.004 17.2 0.1 0.14 12.3 0.0 2.7 3 0 0 3 3 2 1 Torsin Zeta_toxin PF06414.12 CCM00433.1 - 0.005 16.1 0.0 0.14 11.5 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin ResIII PF04851.15 CCM00433.1 - 0.0072 16.3 0.0 1.4 8.9 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit KTI12 PF08433.10 CCM00433.1 - 0.0076 15.7 0.0 2.5 7.4 0.0 2.3 2 0 0 2 2 2 1 Chromatin associated protein KTI12 DUF2075 PF09848.9 CCM00433.1 - 0.0078 15.5 0.1 2.8 7.1 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Hydin_ADK PF17213.3 CCM00433.1 - 0.0084 16.4 0.1 0.15 12.3 0.0 2.2 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain Rad17 PF03215.15 CCM00433.1 - 0.017 15.0 0.1 15 5.4 0.0 3.6 4 0 0 4 4 3 0 Rad17 P-loop domain KAP_NTPase PF07693.14 CCM00433.1 - 0.028 13.7 0.0 13 4.9 0.0 2.9 3 0 0 3 3 3 0 KAP family P-loop domain T2SSE PF00437.20 CCM00433.1 - 0.028 13.5 0.0 5.8 5.9 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 CCM00433.1 - 0.043 13.7 0.1 13 5.7 0.0 2.7 3 0 0 3 3 2 0 NTPase Sigma54_activ_2 PF14532.6 CCM00433.1 - 0.047 13.8 0.0 16 5.6 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 CCM00433.1 - 0.081 12.7 0.0 5.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase AFG1_ATPase PF03969.16 CCM00433.1 - 0.084 11.8 0.0 1.1 8.0 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase Vps4_C PF09336.10 CCM00433.1 - 0.096 12.7 0.1 1 9.4 0.0 2.5 3 0 0 3 3 2 0 Vps4 C terminal oligomerisation domain AAA_29 PF13555.6 CCM00433.1 - 0.11 12.3 0.2 8.3 6.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 CCM00433.1 - 0.11 11.9 0.1 25 4.2 0.0 3.0 2 1 1 3 3 3 0 Bacterial TniB protein cobW PF02492.19 CCM00433.1 - 0.11 12.1 0.1 3 7.4 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DAP3 PF10236.9 CCM00433.1 - 0.12 11.6 0.1 9.5 5.3 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 eIF3m_C_helix PF18005.1 CCM00434.1 - 6.1e-12 45.0 0.2 1.4e-11 43.8 0.2 1.7 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix PCI PF01399.27 CCM00434.1 - 3.1e-09 37.3 0.0 1.4e-05 25.5 0.0 3.2 3 0 0 3 3 3 2 PCI domain HTH_28 PF13518.6 CCM00434.1 - 0.073 13.2 0.9 2 8.6 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain DNA_ligase_A_N PF04675.14 CCM00434.1 - 0.11 12.8 0.1 0.31 11.4 0.1 1.9 2 0 0 2 2 2 0 DNA ligase N terminus DUF2009 PF09418.10 CCM00435.1 - 2.9e-213 709.0 0.0 3.6e-213 708.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 CCM00435.1 - 2.2e-06 27.7 6.8 5.6e-06 26.4 6.8 1.7 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 CCM00435.1 - 0.0067 16.6 5.6 0.014 15.6 5.6 1.5 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-HIT PF04438.16 CCM00435.1 - 0.31 10.9 1.5 0.64 9.9 1.5 1.5 1 0 0 1 1 1 0 HIT zinc finger Hep_59 PF07052.11 CCM00436.1 - 6.5e-29 100.8 1.0 6.5e-29 100.8 1.0 2.6 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 TFIIB PF00382.19 CCM00438.1 - 1.4e-33 114.8 0.0 8.1e-20 70.6 0.0 2.6 3 0 0 3 3 3 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CCM00438.1 - 9.9e-13 47.4 1.2 1.6e-12 46.7 1.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Guanylin PF02058.15 CCM00438.1 - 0.00043 20.7 1.4 0.64 10.5 0.0 3.2 2 1 1 3 3 3 2 Guanylin precursor RB_B PF01857.20 CCM00438.1 - 0.0084 16.1 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Cyclin_N PF00134.23 CCM00438.1 - 0.058 13.1 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCM00438.1 - 0.088 12.9 0.0 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Cyclin, C-terminal domain zinc_ribbon_10 PF10058.9 CCM00438.1 - 0.091 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein RRS1 PF04939.12 CCM00439.1 - 2.8e-59 199.6 4.0 2.8e-59 199.6 4.0 1.6 2 1 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) Glyco_hydro_31 PF01055.26 CCM00439.1 - 0.095 11.9 0.7 0.12 11.5 0.7 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 adh_short PF00106.25 CCM00440.1 - 1.5e-41 142.0 0.0 2e-41 141.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00440.1 - 8.8e-26 90.9 0.0 1.1e-25 90.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM00440.1 - 1.5e-08 34.8 0.1 2e-08 34.3 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM00440.1 - 0.0013 18.7 0.1 0.0015 18.5 0.1 1.3 1 1 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 CCM00440.1 - 0.004 16.6 0.0 0.0064 15.9 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCM00440.1 - 0.071 12.6 0.1 0.18 11.2 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Bac_surface_Ag PF01103.23 CCM00441.1 - 1.1e-39 136.9 0.1 1.3e-39 136.6 0.1 1.1 1 0 0 1 1 1 1 Surface antigen OPT PF03169.15 CCM00442.1 - 1.3e-139 466.7 56.5 1.5e-139 466.5 56.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Pkinase PF00069.25 CCM00443.1 - 7.6e-20 71.4 0.0 3.2e-19 69.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00443.1 - 7.9e-16 58.1 0.0 3.9e-15 55.9 0.0 1.7 1 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM00443.1 - 6.2e-05 21.9 0.0 9.3e-05 21.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CCM00443.1 - 8e-05 22.3 0.6 0.00048 19.8 0.0 2.2 2 1 1 3 3 3 1 RIO1 family APH PF01636.23 CCM00443.1 - 0.00029 20.8 1.0 0.00073 19.5 0.1 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CCM00443.1 - 0.0075 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pro_isomerase PF00160.21 CCM00444.1 - 6.6e-45 153.2 0.4 7.3e-45 153.1 0.4 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_L18A PF01775.17 CCM00446.1 - 3.8e-55 185.2 0.3 4.8e-55 184.8 0.3 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A COG7 PF10191.9 CCM00447.1 - 4.9e-70 236.7 0.0 2.2e-47 161.8 0.0 4.0 4 0 0 4 4 4 4 Golgi complex component 7 (COG7) IBR PF01485.21 CCM00448.1 - 1.1e-06 28.8 31.6 3.4e-05 24.0 9.6 3.5 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain ketoacyl-synt PF00109.26 CCM00451.1 - 2.5e-45 155.1 2.7 4.6e-44 150.9 0.4 3.0 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCM00451.1 - 3.7e-34 118.7 0.0 6.9e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCM00451.1 - 1.5e-27 96.0 0.1 2.8e-27 95.1 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCM00451.1 - 3.3e-13 49.5 0.0 6.9e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCM00451.1 - 9.2e-13 48.6 0.0 2.8e-12 47.1 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CCM00451.1 - 5.5e-06 25.9 0.2 3.1e-05 23.5 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCM00451.1 - 0.0009 19.1 3.3 0.019 14.8 3.3 2.6 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III KR PF08659.10 CCM00452.1 - 3.5e-33 115.0 0.0 2.1e-32 112.5 0.0 2.1 2 0 0 2 2 2 1 KR domain Thioesterase PF00975.20 CCM00452.1 - 3e-21 76.6 0.1 6.2e-21 75.6 0.1 1.5 1 1 0 1 1 1 1 Thioesterase domain Methyltransf_12 PF08242.12 CCM00452.1 - 7.6e-09 36.2 0.0 1.8e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CCM00452.1 - 1.7e-07 31.5 0.0 4.6e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_23 PF13489.6 CCM00452.1 - 8e-05 22.5 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM00452.1 - 0.00026 21.6 0.0 0.00072 20.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CCM00452.1 - 0.00074 19.0 0.0 0.0041 16.6 0.0 2.2 2 1 0 2 2 2 1 short chain dehydrogenase Methyltransf_25 PF13649.6 CCM00452.1 - 0.022 15.5 0.0 0.067 13.9 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CCM00452.1 - 0.042 13.7 0.0 0.097 12.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF2974 PF11187.8 CCM00452.1 - 0.055 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) 3Beta_HSD PF01073.19 CCM00452.1 - 0.13 11.3 0.0 0.34 9.8 0.0 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_24 PF13578.6 CCM00452.1 - 0.16 13.0 0.0 2.3 9.3 0.0 2.9 3 1 1 4 4 3 0 Methyltransferase domain ThiF PF00899.21 CCM00452.1 - 0.16 11.3 1.5 0.38 10.1 1.5 1.5 1 0 0 1 1 1 0 ThiF family GPP34 PF05719.11 CCM00454.1 - 1.5e-67 227.6 2.6 1.9e-67 227.3 2.6 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Chs7 PF12271.8 CCM00455.1 - 1e-79 267.9 5.5 1.2e-79 267.7 5.5 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Zn_clus PF00172.18 CCM00456.1 - 3.2e-08 33.6 10.0 8e-08 32.3 10.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SR-25 PF10500.9 CCM00456.1 - 0.47 10.0 2.9 0.77 9.3 2.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UPF0203 PF05254.12 CCM00457.1 - 9.3e-21 73.9 0.6 1.2e-20 73.5 0.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX6B PF02297.17 CCM00457.1 - 0.23 11.7 3.0 2.2 8.6 3.0 2.0 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb Metallophos_2 PF12850.7 CCM00458.1 - 1.4e-15 57.9 0.1 2e-15 57.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CCM00458.1 - 1.7e-08 35.2 0.3 0.0054 17.3 0.0 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Lipase_3 PF01764.25 CCM00459.1 - 2.4e-08 33.9 0.0 4.3e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Cation_ATPase_C PF00689.21 CCM00460.1 - 3e-09 36.8 0.3 3.3e-09 36.7 0.3 1.0 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus EBP PF05241.12 CCM00461.1 - 0.00013 21.5 3.8 0.00022 20.8 3.8 1.3 1 1 0 1 1 1 1 Emopamil binding protein ATP-synt_Z PF16594.5 CCM00461.1 - 4.4 6.9 8.1 61 3.2 9.1 2.4 2 1 0 2 2 2 0 Putative AtpZ or ATP-synthase-associated HSP20 PF00011.21 CCM00462.1 - 2.8e-22 78.8 0.1 7.8e-22 77.4 0.0 1.7 1 1 1 2 2 2 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCM00462.1 - 3.2e-08 33.0 0.0 5.1e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA VLPT PF07122.11 CCM00462.1 - 0.045 13.5 0.2 0.18 11.6 0.2 2.0 1 1 0 1 1 1 0 Variable length PCR target protein (VLPT) F-box-like PF12937.7 CCM00463.1 - 0.0067 16.3 4.8 1.4 8.8 1.5 2.9 2 0 0 2 2 2 2 F-box-like LRR_2 PF07723.13 CCM00463.1 - 0.054 14.2 0.2 18 6.2 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat F-box PF00646.33 CCM00463.1 - 0.14 12.1 3.8 13 5.8 0.1 3.4 2 1 0 2 2 2 0 F-box domain Glyco_trans_2_3 PF13632.6 CCM00464.1 - 2.6e-56 190.7 0.9 2.6e-56 190.7 0.9 2.2 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCM00464.1 - 3.3e-06 27.2 0.0 6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCM00464.1 - 0.0014 18.4 0.0 0.0086 15.9 0.0 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCM00464.1 - 0.0044 16.5 0.0 0.01 15.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_hydro_16 PF00722.21 CCM00465.1 - 2.6e-18 66.1 0.4 5.9e-18 65.0 0.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 p450 PF00067.22 CCM00466.1 - 2.9e-61 207.7 0.0 2.1e-60 204.8 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 WW PF00397.26 CCM00467.1 - 0.19 11.9 0.9 0.43 10.7 0.9 1.7 1 0 0 1 1 1 0 WW domain tRNA-synt_1g PF09334.11 CCM00468.1 - 1.2e-82 277.7 0.0 2.8e-81 273.3 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCM00468.1 - 5.4e-14 51.4 1.0 1.2e-08 33.8 0.1 3.5 3 1 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CCM00468.1 - 1.6e-12 47.4 0.0 6.1e-06 25.8 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain TPR_2 PF07719.17 CCM00469.1 - 5.9e-07 29.1 4.3 0.098 12.8 0.2 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM00469.1 - 9.4e-06 25.2 0.1 1 9.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 CCM00469.1 - 6e-05 22.9 0.0 0.00019 21.2 0.0 1.9 2 0 0 2 2 2 1 UBA/TS-N domain TPR_16 PF13432.6 CCM00469.1 - 0.00075 20.1 8.0 0.014 16.0 0.1 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM00469.1 - 0.0047 17.2 4.6 0.007 16.6 0.7 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DnaJ PF00226.31 CCM00469.1 - 0.031 14.4 0.0 0.07 13.3 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain TPR_8 PF13181.6 CCM00469.1 - 0.046 14.0 0.2 22 5.6 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCM00469.1 - 0.21 12.3 3.2 9.8 7.1 0.9 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat FliD_N PF02465.18 CCM00469.1 - 0.29 11.9 2.6 0.83 10.4 1.6 2.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Cir_N PF10197.9 CCM00469.1 - 1.7 8.9 6.5 19 5.5 0.4 2.9 2 0 0 2 2 2 0 N-terminal domain of CBF1 interacting co-repressor CIR Coatomer_WDAD PF04053.14 CCM00473.1 - 1e-148 496.1 0.0 1.9e-148 495.2 0.0 1.4 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 CCM00473.1 - 8e-39 130.9 6.6 5.7e-07 30.1 0.0 8.8 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00473.1 - 8e-09 35.7 0.1 0.0015 18.8 0.0 5.8 2 2 4 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CCM00473.1 - 0.00031 20.7 0.1 14 5.8 0.0 4.4 4 1 1 5 5 5 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 CCM00473.1 - 0.0027 16.4 2.3 0.035 12.8 0.1 3.0 1 1 1 3 3 3 1 Nucleoporin Nup120/160 PQQ_2 PF13360.6 CCM00473.1 - 0.042 13.4 1.1 8 6.0 0.1 3.0 3 0 0 3 3 3 0 PQQ-like domain WD40_like PF17005.5 CCM00473.1 - 0.055 12.8 0.0 3.6 6.8 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain Chitin_synth_2 PF03142.15 CCM00474.1 - 9.6e-236 783.5 0.1 1.3e-235 783.0 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 CCM00474.1 - 3e-96 323.2 0.0 2.9e-73 247.2 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) Glyco_tranf_2_3 PF13641.6 CCM00474.1 - 3.1e-15 56.7 0.0 1.4e-13 51.3 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 DEK_C PF08766.11 CCM00474.1 - 1.4e-14 53.8 0.1 3.5e-14 52.5 0.1 1.8 1 0 0 1 1 1 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 CCM00474.1 - 6.8e-13 49.0 3.3 6.8e-13 49.0 3.3 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.28 CCM00474.1 - 4.2e-12 46.0 0.0 9.1e-09 35.3 0.0 2.8 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 CCM00474.1 - 3.6e-08 33.4 0.0 8.4e-05 22.4 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCM00474.1 - 0.00011 21.8 0.1 0.018 14.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 21 NUDIX PF00293.28 CCM00476.1 - 4.3e-09 36.5 0.0 6.1e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain PH_BEACH PF14844.6 CCM00477.1 - 0.0065 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH RabGAP-TBC PF00566.18 CCM00479.1 - 6e-40 137.2 0.1 8.9e-40 136.6 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Adaptin_N PF01602.20 CCM00480.1 - 4.1e-26 91.6 3.3 7.3e-26 90.8 3.3 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCM00480.1 - 3.5e-05 23.9 0.5 0.00016 21.8 0.3 2.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 UFD1 PF03152.14 CCM00481.1 - 2.5e-67 225.7 0.0 3.2e-67 225.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 CCM00481.1 - 0.1 12.4 0.1 0.55 10.1 0.0 2.1 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), domain 2 NMT PF01233.19 CCM00482.1 - 1.7e-78 262.0 0.0 2.7e-78 261.3 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 CCM00482.1 - 6.4e-75 251.3 0.0 9.3e-75 250.7 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 CCM00482.1 - 0.00023 21.2 0.0 0.0014 18.7 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF1576 PF07613.11 CCM00482.1 - 0.16 11.5 0.1 1.6 8.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1576) OGG_N PF07934.12 CCM00483.1 - 2.4e-23 82.5 0.0 3.8e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 CCM00483.1 - 1.7e-14 54.2 0.0 4.2e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCM00483.1 - 0.0046 16.8 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF5539 PF17693.1 CCM00483.1 - 0.012 15.3 2.1 0.02 14.5 2.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5539) LRR_6 PF13516.6 CCM00484.1 - 2.6 8.3 4.6 6.1 7.2 0.3 3.3 3 0 0 3 3 3 0 Leucine Rich repeat p450 PF00067.22 CCM00485.1 - 7.7e-49 166.7 0.0 9e-49 166.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RE_SinI PF09570.10 CCM00485.1 - 0.063 12.5 0.1 0.57 9.4 0.0 2.1 2 0 0 2 2 2 0 SinI restriction endonuclease dCache_3 PF14827.6 CCM00485.1 - 0.1 12.3 0.1 0.3 10.7 0.0 1.8 2 0 0 2 2 2 0 Double sensory domain of two-component sensor kinase ADH_zinc_N PF00107.26 CCM00486.1 - 3.6e-19 69.0 0.3 6.5e-19 68.2 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM00486.1 - 3.1e-09 38.0 0.0 6e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM00486.1 - 5.7e-06 26.2 3.1 1.8e-05 24.6 0.0 2.9 3 1 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ACP_syn_III_C PF08541.10 CCM00486.1 - 0.079 13.1 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ADH_N_2 PF16884.5 CCM00486.1 - 0.095 12.6 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase YL1 PF05764.13 CCM00487.1 - 0.0029 17.8 0.3 0.0043 17.2 0.3 1.2 1 0 0 1 1 1 1 YL1 nuclear protein ApoB100_C PF12491.8 CCM00489.1 - 0.0037 17.2 0.1 2.4 8.2 0.1 2.6 2 0 0 2 2 2 2 Apolipoprotein B100 C terminal DUF1664 PF07889.12 CCM00489.1 - 0.075 13.1 10.8 4.3 7.4 0.4 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Fungal_TACC PF12709.7 CCM00489.1 - 1.4 9.4 6.7 16 6.0 0.1 4.1 4 0 0 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Prp19 PF08606.11 CCM00489.1 - 2.6 8.1 8.9 1.9 8.5 1.5 3.7 3 0 0 3 3 3 0 Prp19/Pso4-like SlyX PF04102.12 CCM00489.1 - 9.4 6.9 19.9 33 5.2 0.4 6.7 5 2 0 5 5 5 0 SlyX Lectin_N PF03954.14 CCM00489.1 - 9.8 5.9 13.1 0.31 10.8 0.3 3.7 4 0 0 4 4 4 0 Hepatic lectin, N-terminal domain YabA PF06156.13 CCM00489.1 - 9.8 6.9 15.9 19 5.9 0.6 4.9 4 1 0 4 4 4 0 Initiation control protein YabA zf-C2H2 PF00096.26 CCM00490.1 - 0.063 13.8 16.4 0.31 11.6 0.0 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type Ribosomal_L37 PF08561.10 CCM00491.1 - 2.4e-15 57.1 6.3 3.6e-13 50.1 0.5 2.3 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 DUF1635 PF07795.11 CCM00491.1 - 0.02 14.8 0.0 0.025 14.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) UCH PF00443.29 CCM00492.1 - 6.4e-44 150.4 0.0 8e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM00492.1 - 5.4e-07 29.5 0.0 0.01 15.4 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PMT PF02366.18 CCM00493.1 - 9.5e-84 280.8 17.9 9.5e-84 280.8 17.9 1.8 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCM00493.1 - 8e-59 198.6 13.5 2.4e-58 197.0 13.5 1.9 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCM00493.1 - 5.8e-27 94.7 0.0 9.3e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 MIR domain Fibrillarin PF01269.17 CCM00494.1 - 1.8e-105 351.1 0.0 2.2e-105 350.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CCM00494.1 - 0.0022 17.7 0.0 0.0032 17.2 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 CCM00494.1 - 0.0032 17.6 0.0 0.0051 16.9 0.0 1.3 1 1 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 CCM00494.1 - 0.02 14.7 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 CCM00494.1 - 0.14 11.7 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 CCM00494.1 - 0.16 11.7 0.0 0.29 10.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain MitMem_reg PF13012.6 CCM00495.1 - 6.4e-37 126.4 2.1 1e-36 125.7 2.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CCM00495.1 - 6.5e-30 103.5 0.0 1.4e-29 102.4 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Connexin PF00029.19 CCM00495.1 - 0.019 14.8 0.1 0.027 14.2 0.1 1.2 1 0 0 1 1 1 0 Connexin Med19 PF10278.9 CCM00495.1 - 1.1 9.2 11.6 2 8.3 11.6 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 COX4 PF02936.14 CCM00496.1 - 2.4e-37 128.0 0.0 2.9e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV FluMu_N PF17891.1 CCM00496.1 - 0.04 13.7 0.4 0.079 12.7 0.3 1.5 1 1 0 1 1 1 0 Mu-like prophage FluMu N-terminal domain Patatin PF01734.22 CCM00496.1 - 0.19 11.9 0.0 0.19 11.9 0.0 1.5 2 0 0 2 2 2 0 Patatin-like phospholipase zf-CCHC PF00098.23 CCM00497.1 - 1.3e-52 173.6 60.9 1.3e-08 34.6 2.9 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 CCM00497.1 - 5.3e-13 48.5 45.3 0.0039 16.9 1.4 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 CCM00497.1 - 1.4e-10 40.9 39.8 0.018 15.0 0.6 7.0 3 2 4 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 CCM00497.1 - 0.014 15.1 38.2 0.033 13.9 0.4 6.7 5 2 2 7 7 7 0 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 CCM00497.1 - 0.026 14.4 55.0 0.17 11.7 0.9 7.3 6 1 1 7 7 7 0 Zinc knuckle adh_short PF00106.25 CCM00498.1 - 5.5e-23 81.4 0.0 7.2e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00498.1 - 1.9e-10 40.7 0.0 2.7e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM00498.1 - 0.0003 20.8 0.0 0.00045 20.2 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCM00498.1 - 0.0055 16.1 0.0 0.59 9.4 0.0 2.2 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Shikimate_DH PF01488.20 CCM00498.1 - 0.0076 16.3 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 CCM00498.1 - 0.0092 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCM00498.1 - 0.0092 15.1 0.1 0.013 14.7 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CCM00498.1 - 0.012 15.9 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CCM00498.1 - 0.013 16.1 0.0 0.025 15.1 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 CCM00498.1 - 0.048 13.1 0.0 0.091 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Adenine_deam_C PF13382.6 CCM00498.1 - 0.086 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain 3HCDH_N PF02737.18 CCM00498.1 - 0.19 11.6 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CCM00499.1 - 1.9e-45 154.4 0.0 2.7e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM00499.1 - 1.4e-19 70.0 0.0 2.1e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.20 CCM00499.1 - 0.019 15.0 0.1 0.2 11.7 0.0 2.5 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CCM00499.1 - 0.079 13.4 0.2 0.96 9.9 0.1 2.7 3 1 0 3 3 3 0 Putative NAD(P)-binding GFO_IDH_MocA PF01408.22 CCM00499.1 - 0.087 13.7 0.0 0.35 11.7 0.0 2.0 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold tRNA-synt_1c PF00749.21 CCM00500.1 - 2.3e-106 355.3 0.0 3e-106 354.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CCM00500.1 - 6.6e-37 127.0 0.2 1.2e-36 126.2 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_2 PF13410.6 CCM00500.1 - 2e-06 27.7 0.1 5.6e-06 26.3 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCM00500.1 - 1.8e-05 24.8 0.0 4.5e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCM00500.1 - 0.0009 19.4 0.1 0.0087 16.2 0.0 2.6 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 CCM00500.1 - 0.0072 15.7 0.8 0.014 14.7 0.4 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain AIMP2_LysRS_bd PF16780.5 CCM00500.1 - 0.2 11.4 0.2 0.45 10.3 0.2 1.6 1 0 0 1 1 1 0 AIMP2 lysyl-tRNA synthetase binding domain Methyltransf_10 PF05971.12 CCM00501.1 - 4.8e-49 167.3 0.1 5.2e-31 108.1 0.0 3.1 3 0 0 3 3 3 3 RNA methyltransferase MTS PF05175.14 CCM00501.1 - 0.0021 17.6 0.0 0.017 14.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CCM00501.1 - 0.03 13.7 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Metallophos PF00149.28 CCM00502.1 - 1.1e-08 35.8 0.1 3.2e-08 34.3 0.1 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCM00502.1 - 5.5e-05 23.4 1.2 0.0026 17.9 1.2 2.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 CCM00502.1 - 0.086 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily MtmB PF05369.12 CCM00502.1 - 0.19 10.5 0.1 0.25 10.1 0.1 1.1 1 0 0 1 1 1 0 Monomethylamine methyltransferase MtmB HMGL-like PF00682.19 CCM00503.1 - 9.7e-73 245.0 0.0 1.4e-72 244.4 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CCM00503.1 - 7.8e-46 155.3 0.3 1.5e-23 83.2 0.0 2.5 2 0 0 2 2 2 2 LeuA allosteric (dimerisation) domain DUF382 PF04037.13 CCM00504.1 - 4.5e-59 198.1 1.8 5.5e-59 197.9 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 CCM00504.1 - 2e-17 62.8 4.6 4.3e-17 61.7 4.6 1.6 1 0 0 1 1 1 1 PSP Chalcone PF02431.15 CCM00504.1 - 0.019 14.4 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Chalcone-flavanone isomerase DEAD PF00270.29 CCM00505.1 - 1.9e-44 151.5 0.7 1.9e-44 151.5 0.7 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM00505.1 - 5.5e-33 113.6 0.5 1.8e-31 108.7 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM00505.1 - 8e-06 26.0 0.0 1.5e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCM00505.1 - 0.00016 22.0 0.5 0.0049 17.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCM00505.1 - 0.0011 18.8 0.1 0.0019 17.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 CCM00505.1 - 0.049 13.1 0.1 0.063 12.8 0.1 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Flavi_DEAD PF07652.14 CCM00505.1 - 0.12 12.3 0.1 0.5 10.3 0.1 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain AAA_22 PF13401.6 CCM00505.1 - 0.19 12.0 1.6 0.81 10.0 0.5 2.5 2 1 0 2 2 2 0 AAA domain DSPc PF00782.20 CCM00506.1 - 4.1e-25 88.1 0.0 5.7e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 CCM00506.1 - 0.004 17.4 0.0 0.0061 16.8 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 CCM00506.1 - 0.0095 15.5 0.0 0.012 15.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF4062 PF13271.6 CCM00506.1 - 0.038 14.3 0.0 0.063 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) DSPn PF14671.6 CCM00506.1 - 0.077 13.4 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Myotub-related PF06602.14 CCM00506.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Ras PF00071.22 CCM00507.1 - 4e-48 163.1 0.0 5e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM00507.1 - 3.4e-27 95.0 0.0 4.8e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM00507.1 - 1.9e-10 40.4 0.0 2.3e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM00507.1 - 0.00087 18.9 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCM00507.1 - 0.0028 17.7 0.0 0.0054 16.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP-synt_Eps PF04627.13 CCM00508.1 - 2.6e-21 75.3 2.8 3.1e-21 75.1 2.8 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain CHAT PF12770.7 CCM00511.1 - 2.3e-31 109.3 0.0 5e-31 108.2 0.0 1.6 1 0 0 1 1 1 1 CHAT domain TPR_12 PF13424.6 CCM00511.1 - 8.2e-11 42.0 36.3 0.14 12.5 0.1 12.0 12 2 1 13 13 13 5 Tetratricopeptide repeat TPR_10 PF13374.6 CCM00511.1 - 8.9e-07 28.6 55.4 0.063 13.2 0.0 14.2 17 1 0 17 17 17 5 Tetratricopeptide repeat TPR_11 PF13414.6 CCM00511.1 - 0.0085 15.8 6.5 35 4.2 0.0 7.2 7 1 0 7 7 7 0 TPR repeat TPR_7 PF13176.6 CCM00511.1 - 1.2 9.3 22.7 58 4.0 0.0 9.7 11 0 0 11 11 11 0 Tetratricopeptide repeat PspA_IM30 PF04012.12 CCM00511.1 - 2.4 7.7 5.1 0.59 9.7 0.2 2.2 2 0 0 2 2 2 0 PspA/IM30 family TPR_1 PF00515.28 CCM00511.1 - 2.7 8.0 19.5 3.1 7.8 0.1 8.8 9 0 0 9 9 9 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 CCM00512.1 - 2.8e-20 73.3 0.0 4.6e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Caspase domain CHAT PF12770.7 CCM00512.1 - 0.0096 15.4 0.0 0.04 13.3 0.0 2.0 2 1 0 2 2 2 1 CHAT domain Peptidase_C14 PF00656.22 CCM00513.1 - 8.1e-23 81.6 0.0 1.2e-22 81.0 0.0 1.3 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.22 CCM00515.1 - 7.8e-23 81.7 0.0 1.7e-22 80.6 0.0 1.5 1 0 0 1 1 1 1 Caspase domain FlgT_C PF16538.5 CCM00515.1 - 0.00042 20.8 0.0 0.00093 19.7 0.0 1.6 1 0 0 1 1 1 1 Flagellar assembly protein T, C-terminal domain Peptidase_C14 PF00656.22 CCM00516.1 - 6.8e-22 78.6 0.0 1.3e-21 77.7 0.0 1.4 1 1 0 1 1 1 1 Caspase domain Pkinase_Tyr PF07714.17 CCM00517.1 - 1.5e-46 158.8 0.0 2e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM00517.1 - 7.8e-45 153.3 0.0 1.1e-44 152.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SAP PF02037.27 CCM00517.1 - 0.003 17.3 0.3 0.0096 15.7 0.3 2.0 1 0 0 1 1 1 1 SAP domain APH PF01636.23 CCM00517.1 - 0.034 14.1 0.0 0.098 12.6 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM00517.1 - 0.042 12.6 0.0 0.13 11.1 0.0 1.7 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 CCM00517.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 AMP-binding PF00501.28 CCM00518.1 - 3.3e-49 167.6 0.6 9.9e-29 100.2 0.0 2.8 1 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CCM00518.1 - 5.8e-18 65.6 0.1 1.6e-17 64.2 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Npa1 PF11707.8 CCM00519.1 - 3.8e-100 335.6 1.8 1.5e-99 333.6 0.5 2.4 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 CCM00519.1 - 1.1e-50 172.1 0.1 1.1e-50 172.1 0.1 2.4 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Creb_binding PF09030.10 CCM00519.1 - 0.0068 17.1 0.0 0.022 15.5 0.0 1.8 1 0 0 1 1 1 1 Creb binding Rsa3 PF14615.6 CCM00520.1 - 1.2e-16 60.0 0.1 1.7e-16 59.5 0.1 1.3 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Cwf_Cwc_15 PF04889.12 CCM00520.1 - 0.019 14.7 6.7 0.036 13.8 6.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DTHCT PF08070.11 CCM00520.1 - 2.1 9.1 18.0 17 6.2 18.0 2.1 1 1 0 1 1 1 0 DTHCT (NUC029) region AIRC PF00731.20 CCM00521.1 - 4.4e-61 204.8 1.6 9e-61 203.8 1.6 1.5 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 CCM00521.1 - 1e-56 191.2 0.0 1.5e-56 190.7 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 CCM00521.1 - 1.6e-19 69.3 0.4 2.8e-19 68.5 0.4 1.4 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 CCM00521.1 - 0.0008 19.0 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 CCM00521.1 - 0.0054 16.3 0.0 0.023 14.3 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus F-box PF00646.33 CCM00522.1 - 3.7e-05 23.5 0.0 0.00012 21.9 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCM00522.1 - 0.07 13.0 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 F-box-like Aminotran_1_2 PF00155.21 CCM00523.1 - 1.7e-22 80.1 0.0 2.1e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCM00523.1 - 0.061 12.1 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Beta_elim_lyase PF01212.21 CCM00523.1 - 0.16 11.2 0.0 0.36 10.1 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase F-box PF00646.33 CCM00525.1 - 0.00051 19.8 0.2 0.0016 18.2 0.2 1.9 1 0 0 1 1 1 1 F-box domain AAA_assoc_2 PF16193.5 CCM00527.1 - 0.0022 18.3 0.3 0.013 15.8 0.1 2.4 2 0 0 2 2 2 1 AAA C-terminal domain CLP1_P PF16575.5 CCM00528.1 - 1.9e-36 125.6 0.0 6.3e-36 123.9 0.0 1.8 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 CCM00528.1 - 6e-34 116.1 0.0 1e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 CCM00528.1 - 4.3e-25 88.4 0.0 7.3e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 Pyr_redox_2 PF07992.14 CCM00529.1 - 7.4e-39 133.7 0.0 2e-38 132.3 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM00529.1 - 2.3e-11 44.1 0.2 5.5e-06 26.9 0.0 3.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 CCM00529.1 - 2.4e-10 39.2 1.4 7.9e-05 21.9 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CCM00529.1 - 1.2e-09 37.4 0.7 0.00027 20.6 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 CCM00529.1 - 1.2e-09 38.4 3.6 3.8e-07 30.5 1.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCM00529.1 - 2.7e-06 26.6 2.6 0.0011 18.3 0.6 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CCM00529.1 - 8.7e-05 22.3 0.7 0.28 11.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair Pyr_redox_3 PF13738.6 CCM00529.1 - 0.00038 19.8 0.0 0.0036 16.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCM00529.1 - 0.0066 16.9 0.0 0.18 12.2 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding Bd3614-deam PF14439.6 CCM00529.1 - 0.082 13.0 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Bd3614-like deaminase EF-hand_4 PF12763.7 CCM00529.1 - 0.22 11.5 2.0 13 5.8 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand LRR_4 PF12799.7 CCM00530.1 - 0.00031 21.1 1.0 1.2 9.7 0.0 3.6 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) Asp PF00026.23 CCM00531.1 - 5.3e-70 236.3 7.0 6.7e-70 236.0 7.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM00531.1 - 1.6e-10 41.5 0.8 0.00012 22.4 0.3 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Pkinase_Tyr PF07714.17 CCM00532.1 - 2.7e-49 167.8 0.0 4e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM00532.1 - 4.3e-35 121.4 0.0 6.9e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 CCM00532.1 - 0.0023 17.3 0.0 0.0057 16.0 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM00532.1 - 0.012 15.2 0.1 0.024 14.2 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 CCM00532.1 - 0.033 13.5 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 CCM00532.1 - 0.072 13.0 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCM00532.1 - 0.081 11.9 0.0 32 3.3 0.0 3.1 3 0 0 3 3 3 0 Haspin like kinase domain S-AdoMet_synt_C PF02773.16 CCM00533.1 - 1.2e-67 226.1 1.0 2.7e-67 225.0 0.1 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CCM00533.1 - 3e-47 159.8 0.0 5.7e-47 158.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CCM00533.1 - 4.6e-45 152.3 0.2 1e-44 151.3 0.2 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 CCM00533.1 - 0.017 14.0 0.1 0.14 10.9 0.0 2.1 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) S-antigen PF05756.11 CCM00533.1 - 0.078 13.4 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 S-antigen protein Myotub-related PF06602.14 CCM00534.1 - 1.9e-149 497.4 0.1 2.3e-149 497.1 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 CCM00534.1 - 0.025 14.5 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 GRAM domain Y_phosphatase PF00102.27 CCM00534.1 - 0.085 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.20 CCM00534.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain LYRIC PF15686.5 CCM00534.1 - 0.14 11.7 0.1 0.23 11.0 0.1 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Bax1-I PF01027.20 CCM00534.1 - 2.2 8.1 7.3 3.5 7.4 7.3 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Glyco_hydro_43 PF04616.14 CCM00535.1 - 2.4e-34 119.0 2.7 4.2e-34 118.2 2.5 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_43 PF04616.14 CCM00536.1 - 1.1e-40 139.8 0.7 1.7e-40 139.2 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF3808 PF10300.9 CCM00537.1 - 4.5e-78 263.1 0.0 6.9e-78 262.5 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 CCM00537.1 - 6.4e-05 22.8 13.3 0.017 15.2 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM00537.1 - 0.031 14.1 0.8 0.76 9.7 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 CCM00537.1 - 0.076 13.4 0.2 13 6.5 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCM00537.1 - 0.079 13.2 2.2 2.2 8.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCM00537.1 - 0.32 11.9 5.1 16 6.6 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCM00537.1 - 0.36 11.2 6.1 1.1 9.6 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Glyco_hydro_38N PF01074.22 CCM00538.1 - 1.7e-78 263.9 0.1 3e-78 263.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 CCM00538.1 - 1.4e-52 178.8 0.0 2.2e-52 178.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 CCM00538.1 - 6.4e-28 96.7 0.0 1.3e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 CCM00538.1 - 2.1e-05 24.6 0.0 4.1e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain GFO_IDH_MocA PF01408.22 CCM00539.1 - 1.6e-13 51.5 0.0 2.3e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Corona_NS2A PF05213.12 CCM00539.1 - 0.15 11.4 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Coronavirus NS2A protein Aerolysin PF01117.20 CCM00540.1 - 0.068 12.4 0.0 0.099 11.8 0.0 1.1 1 0 0 1 1 1 0 Aerolysin toxin Fascin PF06268.13 CCM00540.1 - 0.087 13.1 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Fascin domain ETX_MTX2 PF03318.13 CCM00540.1 - 0.16 11.7 3.2 0.3 10.8 3.2 1.5 1 1 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Cupin_8 PF13621.6 CCM00541.1 - 3.2e-48 164.7 0.0 5.1e-48 164.0 0.0 1.4 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCM00541.1 - 0.00011 21.8 0.0 0.29 10.5 0.0 2.8 3 0 0 3 3 3 2 Cupin superfamily protein BUD22 PF09073.10 CCM00541.1 - 0.58 9.4 5.3 0.81 9.0 5.3 1.1 1 0 0 1 1 1 0 BUD22 DUF4611 PF15387.6 CCM00541.1 - 1.2 9.4 4.4 0.38 11.0 1.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) HalX PF08663.10 CCM00541.1 - 7.5 7.0 6.4 14 6.0 0.6 2.4 2 0 0 2 2 2 0 HalX domain IBR PF01485.21 CCM00543.1 - 2.1e-07 31.1 34.5 4.2e-06 26.9 7.2 3.4 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain adh_short PF00106.25 CCM00544.1 - 3.8e-28 98.3 0.1 5.3e-28 97.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00544.1 - 5.7e-22 78.4 0.1 7.3e-22 78.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 CCM00544.1 - 0.00022 20.9 0.1 0.00034 20.3 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 CCM00544.1 - 0.00077 19.4 0.0 0.0022 18.0 0.0 1.7 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CCM00544.1 - 0.0013 18.6 0.0 0.0022 17.9 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCM00544.1 - 0.09 12.2 0.0 2.2 7.7 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Alpha-amylase PF00128.24 CCM00545.1 - 5.2e-57 193.9 0.5 7.4e-57 193.4 0.5 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CCM00545.1 - 5.6e-13 49.0 0.1 1.2e-12 47.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Alpha-amylase PF00128.24 CCM00546.1 - 7e-58 196.8 0.8 1.3e-57 195.9 0.8 1.4 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CCM00546.1 - 4.6e-13 49.2 0.1 8.8e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) DUF4408 PF14364.6 CCM00546.1 - 0.64 9.8 2.9 0.31 10.8 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4408) Beta-lactamase PF00144.24 CCM00547.1 - 4.1e-41 141.3 0.1 5.6e-41 140.9 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 CCM00547.1 - 0.00031 21.1 0.0 0.0044 17.5 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3471) adh_short PF00106.25 CCM00548.1 - 8.8e-23 80.8 1.9 1.4e-22 80.1 1.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00548.1 - 5.7e-21 75.1 0.3 7.6e-21 74.7 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM00549.1 - 5.8e-28 97.7 0.3 6.9e-28 97.4 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00549.1 - 1.1e-21 77.5 0.3 1.5e-21 77.1 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 CCM00549.1 - 0.0021 18.0 0.1 0.0035 17.3 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YjeF_N PF03853.15 CCM00549.1 - 0.015 15.2 0.1 0.041 13.8 0.0 1.7 2 0 0 2 2 2 0 YjeF-related protein N-terminus PIP5K PF01504.18 CCM00550.1 - 1e-43 149.6 5.0 1.6e-37 129.2 0.0 2.5 3 0 0 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase Pro_isomerase PF00160.21 CCM00551.1 - 3.2e-38 131.5 0.0 9.3e-37 126.7 0.0 2.0 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF2470 PF10615.9 CCM00552.1 - 9e-23 80.7 0.0 1.4e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 CCM00552.1 - 1.7e-09 37.9 1.5 3e-09 37.1 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) DIM1 PF02966.16 CCM00553.1 - 4.3e-68 227.2 0.1 4.9e-68 227.0 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CCM00553.1 - 2.8e-05 24.0 0.0 3.7e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CCM00553.1 - 0.0052 17.1 0.5 0.0079 16.5 0.4 1.3 1 1 0 1 1 1 1 Thioredoxin-like Thioredox_DsbH PF03190.15 CCM00553.1 - 0.015 15.3 0.2 0.026 14.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 GIDA PF01134.22 CCM00554.1 - 8.5e-154 512.4 0.0 1e-153 512.1 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CCM00554.1 - 5.1e-58 196.7 0.0 8e-58 196.1 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 CCM00554.1 - 5.9e-06 25.9 0.8 9.3e-06 25.2 0.8 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM00554.1 - 1.5e-05 24.3 1.0 4.5e-05 22.8 0.8 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM00554.1 - 0.00083 18.5 3.0 0.002 17.3 3.0 1.7 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CCM00554.1 - 0.0025 16.6 1.3 0.091 11.4 0.5 2.3 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CCM00554.1 - 0.021 14.1 0.3 0.037 13.3 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CCM00554.1 - 0.087 13.4 0.5 0.2 12.3 0.5 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM00554.1 - 0.18 12.1 1.6 0.66 10.3 1.6 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM00554.1 - 0.71 9.4 3.1 3.8 7.0 1.4 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase zf-CSL PF05207.13 CCM00555.1 - 1.1e-22 79.5 0.8 2e-22 78.6 0.8 1.4 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 CCM00555.1 - 0.00051 20.1 0.9 0.0012 19.0 0.9 1.6 1 0 0 1 1 1 1 Zinc ribbon domain Terminase_GpA PF05876.12 CCM00555.1 - 0.0034 16.0 0.3 0.0042 15.7 0.3 1.2 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) Importin_rep_4 PF18808.1 CCM00555.1 - 0.1 12.9 1.7 0.15 12.3 1.7 1.3 1 0 0 1 1 1 0 Importin repeat GAGA PF09237.11 CCM00555.1 - 0.11 12.3 0.2 0.17 11.7 0.2 1.3 1 0 0 1 1 1 0 GAGA factor Prenyltrans PF00432.21 CCM00556.1 - 3e-54 180.4 1.9 4.7e-11 42.2 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CCM00556.1 - 0.00053 19.2 0.0 0.18 10.9 0.0 3.4 2 1 2 4 4 4 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 CCM00556.1 - 0.00067 18.9 0.0 0.0017 17.6 0.0 1.6 1 1 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain Rad60-SLD PF11976.8 CCM00557.1 - 1.1e-24 86.0 0.4 1.4e-24 85.7 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCM00557.1 - 8.4e-15 54.3 0.1 9.8e-15 54.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family UreE_N PF02814.15 CCM00557.1 - 0.12 12.0 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 UreE urease accessory protein, N-terminal domain TMEM239 PF15841.5 CCM00559.1 - 3.1 7.7 9.1 12 5.8 3.8 2.2 1 1 1 2 2 2 0 Transmembrane protein 239 family MFS_1 PF07690.16 CCM00560.1 - 2.5e-24 85.9 60.3 1.8e-17 63.4 40.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ECH_2 PF16113.5 CCM00561.1 - 2.8e-98 329.5 0.0 3.6e-98 329.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CCM00561.1 - 1e-21 77.4 0.0 1.7e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Zip PF02535.22 CCM00562.1 - 4.1 6.5 4.3 5.6 6.1 4.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GMC_oxred_N PF00732.19 CCM00565.1 - 1.4e-51 175.6 0.0 3.1e-51 174.5 0.0 1.5 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM00565.1 - 1e-15 58.5 0.1 6.4e-07 30.0 0.1 2.4 1 1 1 2 2 2 2 GMC oxidoreductase NAD_binding_8 PF13450.6 CCM00565.1 - 0.00015 21.9 0.3 0.00091 19.4 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCM00565.1 - 0.00038 19.6 0.2 0.00054 19.1 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCM00565.1 - 0.00068 18.8 0.2 0.005 16.0 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 CCM00565.1 - 0.00083 18.7 0.1 0.0015 17.8 0.1 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCM00565.1 - 0.0035 17.0 0.3 0.011 15.3 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCM00565.1 - 0.029 13.6 0.9 0.53 9.5 0.5 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM00565.1 - 0.041 12.6 0.0 0.23 10.1 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein TrkA_N PF02254.18 CCM00565.1 - 0.13 12.5 0.1 0.26 11.6 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Glyco_hydro_31 PF01055.26 CCM00566.1 - 3.2e-116 389.1 3.0 3.9e-116 388.8 3.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CCM00567.1 - 1.6e-29 102.4 0.0 3e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Glyco_hydro_31 PF01055.26 CCM00567.1 - 9.1e-12 44.9 0.0 1.3e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCM00567.1 - 8.9e-08 32.3 0.1 2.6e-07 30.9 0.1 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like CFEM PF05730.11 CCM00568.1 - 0.00019 21.5 14.4 0.0004 20.4 14.4 1.5 1 0 0 1 1 1 1 CFEM domain Acetyltransf_4 PF13420.7 CCM00569.1 - 3.5e-12 46.7 0.0 6.2e-09 36.2 0.0 2.1 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CCM00569.1 - 7e-09 36.5 0.0 1.1e-08 35.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM00569.1 - 4.3e-08 33.4 0.0 5.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCM00569.1 - 1.1e-05 25.8 0.0 1.6e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCM00569.1 - 0.0014 18.6 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CCM00569.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 CCM00569.1 - 0.054 13.1 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase FR47 PF08445.10 CCM00569.1 - 0.071 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_15 PF17013.5 CCM00569.1 - 0.16 11.4 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 Putative acetyl-transferase DHH PF01368.20 CCM00571.1 - 4e-06 27.0 0.0 7.9e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 DHH family CDO_I PF05995.12 CCM00576.1 - 5.1e-05 22.6 0.0 8.8e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 CCM00576.1 - 0.00017 21.1 0.6 0.00055 19.4 0.6 1.8 1 1 0 1 1 1 1 PCO_ADO AMP-binding PF00501.28 CCM00577.1 - 3.5e-22 78.6 0.0 7.8e-20 70.9 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme GH3 PF03321.13 CCM00577.1 - 0.0083 15.0 0.1 0.012 14.5 0.1 1.1 1 0 0 1 1 1 1 GH3 auxin-responsive promoter zf-CCCH_4 PF18044.1 CCM00578.1 - 0.00081 19.1 6.2 0.00081 19.1 6.2 2.6 2 0 0 2 2 2 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CCM00578.1 - 0.006 16.8 3.1 0.012 15.8 3.1 1.5 1 0 0 1 1 1 1 Zinc-finger containing family ABC_tran PF00005.27 CCM00579.1 - 3.1e-44 150.8 2.0 1.6e-26 93.5 0.1 3.0 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 CCM00579.1 - 2.9e-38 132.1 28.1 4.2e-20 72.5 2.7 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 CCM00579.1 - 1.5e-11 44.2 5.2 0.0066 15.9 0.6 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM00579.1 - 1.4e-06 29.0 0.2 0.0022 18.5 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCM00579.1 - 2.2e-06 28.1 1.3 0.016 15.6 0.7 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CCM00579.1 - 5.9e-06 25.9 0.4 0.096 12.4 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CCM00579.1 - 1.8e-05 24.7 4.0 0.91 9.3 0.1 4.2 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCM00579.1 - 0.00036 20.2 0.5 0.8 9.3 0.0 2.9 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 CCM00579.1 - 0.00054 20.0 0.2 0.22 11.6 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 CCM00579.1 - 0.00071 19.0 0.1 0.33 10.3 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family DUF87 PF01935.17 CCM00579.1 - 0.0017 18.5 0.8 0.098 12.7 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_7 PF12775.7 CCM00579.1 - 0.0022 17.5 0.1 0.37 10.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region T2SSE PF00437.20 CCM00579.1 - 0.0023 17.1 1.2 0.11 11.5 0.1 2.7 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_22 PF13401.6 CCM00579.1 - 0.0057 16.9 1.0 7.8 6.8 0.0 3.0 2 1 0 2 2 2 0 AAA domain ResIII PF04851.15 CCM00579.1 - 0.0081 16.2 0.0 0.35 10.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCM00579.1 - 0.0095 15.7 0.6 2.3 8.0 0.2 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase RsgA_GTPase PF03193.16 CCM00579.1 - 0.01 15.8 0.1 4.2 7.3 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase IstB_IS21 PF01695.17 CCM00579.1 - 0.031 14.0 0.7 5.9 6.6 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_5 PF07728.14 CCM00579.1 - 0.064 13.3 0.2 14 5.7 0.0 3.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Adeno_IVa2 PF02456.15 CCM00579.1 - 0.076 11.8 0.0 2.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein Pox_A32 PF04665.12 CCM00579.1 - 0.08 12.4 1.2 6.3 6.2 0.1 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_18 PF13238.6 CCM00579.1 - 0.09 13.3 0.0 20 5.7 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 CCM00579.1 - 0.092 12.4 0.2 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 CCM00579.1 - 0.094 12.8 0.2 8 6.5 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_30 PF13604.6 CCM00579.1 - 0.15 11.8 0.8 5.1 6.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 CCM00579.1 - 0.33 10.5 1.6 2.7 7.5 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MWFE PF15879.5 CCM00579.1 - 0.35 11.1 1.8 1.6 8.9 1.8 2.3 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase MWFE subunit PLDc_N PF13396.6 CCM00579.1 - 1.2 9.2 6.2 0.29 11.1 2.0 2.2 2 0 0 2 2 1 0 Phospholipase_D-nuclease N-terminal TrwB_AAD_bind PF10412.9 CCM00579.1 - 1.3 7.9 7.0 4.4 6.1 0.2 2.7 3 0 0 3 3 2 0 Type IV secretion-system coupling protein DNA-binding domain Isy1 PF06246.12 CCM00580.1 - 3e-93 312.1 4.7 3.9e-93 311.7 4.7 1.2 1 0 0 1 1 1 1 Isy1-like splicing family DNA_pack_C PF02499.15 CCM00581.1 - 0.095 11.6 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Probable DNA packing protein, C-terminus LysM PF01476.20 CCM00582.1 - 7.5e-52 173.2 7.1 2.1e-08 34.1 0.1 7.4 7 0 0 7 7 7 7 LysM domain Glyco_hydro_18 PF00704.28 CCM00583.1 - 6e-72 243.0 0.1 9.3e-72 242.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 CCM00583.1 - 6.4e-15 55.4 53.5 6.3e-12 45.8 14.5 3.3 3 0 0 3 3 3 2 Chitin recognition protein WD40 PF00400.32 CCM00584.1 - 2.5e-46 154.7 27.1 3.6e-08 33.9 0.5 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00584.1 - 1.7e-08 34.6 2.8 0.2 12.0 0.0 4.8 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CHAP PF05257.16 CCM00584.1 - 1.5e-05 25.5 3.2 2 9.1 0.3 4.4 2 1 0 3 3 3 2 CHAP domain PQQ_3 PF13570.6 CCM00584.1 - 0.011 16.2 1.5 5.3 7.7 0.0 4.6 3 2 2 5 5 5 0 PQQ-like domain AAA_16 PF13191.6 CCM00584.1 - 0.018 15.4 0.0 0.054 13.9 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 CCM00584.1 - 0.055 13.4 0.1 0.21 11.5 0.1 2.0 1 1 0 1 1 1 0 NACHT domain Nup160 PF11715.8 CCM00584.1 - 0.12 11.0 0.2 32 3.0 0.0 3.7 5 0 0 5 5 5 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CCM00584.1 - 2.2 6.9 7.0 5.1 5.7 0.8 3.5 1 1 2 3 3 3 0 Nup133 N terminal like WD40 PF00400.32 CCM00585.1 - 1.6e-117 380.0 72.0 7.5e-09 36.1 0.8 15.4 16 0 0 16 16 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00585.1 - 1.5e-19 70.1 27.3 1.6 9.1 0.0 13.5 1 1 11 14 14 14 6 Anaphase-promoting complex subunit 4 WD40 domain FeThRed_A PF02941.15 CCM00585.1 - 4.7e-07 29.9 2.3 19 5.5 0.0 9.3 7 4 4 11 11 11 0 Ferredoxin thioredoxin reductase variable alpha chain AAA_16 PF13191.6 CCM00585.1 - 2.9e-06 27.8 0.1 8e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain PQQ PF01011.21 CCM00585.1 - 6.1e-06 25.9 0.0 23 5.1 0.0 7.5 8 0 0 8 8 7 0 PQQ enzyme repeat WD40_like PF17005.5 CCM00585.1 - 8.5e-06 25.3 0.8 15 4.7 0.0 7.4 6 4 1 8 8 8 0 WD40-like domain NACHT PF05729.12 CCM00585.1 - 1.4e-05 25.0 0.3 7.6e-05 22.7 0.3 2.1 1 1 0 1 1 1 1 NACHT domain CHAP PF05257.16 CCM00585.1 - 0.00011 22.7 24.9 0.41 11.3 0.1 9.8 1 1 9 11 11 11 1 CHAP domain Nup160 PF11715.8 CCM00585.1 - 0.00035 19.3 26.1 13 4.3 0.0 10.7 9 4 3 13 13 13 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CCM00585.1 - 0.0005 18.7 18.9 0.097 11.2 0.4 5.9 2 2 4 7 7 7 4 Cytochrome D1 heme domain DUF727 PF05303.12 CCM00585.1 - 0.00095 19.2 1.9 6.8 6.8 0.0 6.6 6 2 3 10 10 9 1 Protein of unknown function (DUF727) AAA_22 PF13401.6 CCM00585.1 - 0.0029 17.9 0.0 0.0064 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Peptidase_S9_N PF02897.15 CCM00585.1 - 0.041 12.7 3.7 15 4.2 0.1 5.6 1 1 3 6 6 6 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Nucleoporin_N PF08801.11 CCM00585.1 - 0.079 11.7 35.2 3.7 6.2 0.3 9.5 1 1 6 9 9 9 0 Nup133 N terminal like NB-ARC PF00931.22 CCM00585.1 - 0.18 11.0 0.0 0.4 9.8 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain DUF1264 PF06884.11 CCM00585.1 - 0.39 10.3 3.5 34 4.0 0.0 5.2 4 4 4 8 8 8 0 Protein of unknown function (DUF1264) zf-C3HC4 PF00097.25 CCM00586.1 - 2.2e-06 27.4 8.3 6.6e-06 25.9 8.4 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCM00586.1 - 9.9e-05 22.6 13.9 0.0002 21.6 13.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CCM00586.1 - 0.00028 20.9 7.3 0.00028 20.9 7.3 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCM00586.1 - 0.00049 19.9 14.6 0.024 14.5 15.0 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Exonuc_VII_L PF02601.15 CCM00586.1 - 0.01 15.5 11.6 0.015 14.9 11.6 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit ATG16 PF08614.11 CCM00586.1 - 0.011 16.0 19.2 0.019 15.2 19.2 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) zf-C3HC4_4 PF15227.6 CCM00586.1 - 0.014 15.5 10.7 0.043 14.0 10.3 2.0 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DUF3552 PF12072.8 CCM00586.1 - 0.022 14.2 22.2 0.11 11.9 21.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) DUF745 PF05335.13 CCM00586.1 - 0.03 14.1 6.7 0.049 13.3 6.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) zf-RING_6 PF14835.6 CCM00586.1 - 0.055 13.4 4.5 0.13 12.2 4.4 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein TMCO5 PF14992.6 CCM00586.1 - 0.08 12.5 8.3 0.11 12.1 8.3 1.2 1 0 0 1 1 1 0 TMCO5 family LMBR1 PF04791.16 CCM00586.1 - 0.088 11.7 3.0 0.11 11.3 3.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 CCM00586.1 - 0.2 12.0 17.0 0.57 10.5 17.0 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) zf-C3HC4_3 PF13920.6 CCM00586.1 - 0.2 11.5 10.1 0.84 9.5 10.1 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DASH_Spc34 PF08657.10 CCM00586.1 - 0.48 10.2 10.7 0.78 9.5 10.7 1.3 1 0 0 1 1 1 0 DASH complex subunit Spc34 DUF16 PF01519.16 CCM00586.1 - 0.51 10.9 11.5 0.11 12.9 5.1 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 GPAT_N PF14829.6 CCM00586.1 - 0.57 10.2 1.7 0.53 10.3 0.1 1.8 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal Sec34 PF04136.15 CCM00586.1 - 0.76 9.6 7.9 1.1 9.1 7.9 1.2 1 0 0 1 1 1 0 Sec34-like family DUF3584 PF12128.8 CCM00586.1 - 1 6.8 16.6 1.3 6.4 16.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4200 PF13863.6 CCM00586.1 - 1.1 9.7 20.2 2.4 8.6 6.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) WDCP PF15390.6 CCM00586.1 - 1.5 7.2 8.3 2 6.7 8.3 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Ndc1_Nup PF09531.10 CCM00586.1 - 1.6 7.3 3.7 2 7.0 3.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-rbx1 PF12678.7 CCM00586.1 - 1.6 9.0 12.6 5.5 7.3 12.6 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain AAA_11 PF13086.6 CCM00586.1 - 1.7 8.4 11.0 2.7 7.7 11.0 1.3 1 0 0 1 1 1 0 AAA domain zf-RING_5 PF14634.6 CCM00586.1 - 1.7 8.6 13.0 10 6.2 12.0 2.4 1 1 0 1 1 1 0 zinc-RING finger domain Spc7 PF08317.11 CCM00586.1 - 1.8 7.4 14.5 2.7 6.8 14.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_32 PF13654.6 CCM00586.1 - 2.1 7.1 9.7 2.8 6.6 9.7 1.1 1 0 0 1 1 1 0 AAA domain zf-RING_10 PF16685.5 CCM00586.1 - 2.6 8.3 9.1 0.11 12.6 3.5 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 FapA PF03961.13 CCM00586.1 - 2.6 6.5 9.0 3.5 6.1 9.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 CCM00586.1 - 2.7 7.3 12.1 4.2 6.6 12.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4061 PF13270.6 CCM00586.1 - 4.7 7.6 10.5 3.7 7.9 8.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) V_ATPase_I PF01496.19 CCM00586.1 - 6.1 4.6 8.1 7.9 4.3 8.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Actin PF00022.19 CCM00587.1 - 2.4e-27 95.6 0.0 1.5e-11 43.5 0.0 3.2 3 0 0 3 3 3 3 Actin Actin_micro PF17003.5 CCM00587.1 - 2.1e-14 53.5 0.0 5.4e-08 32.4 0.0 2.1 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 CCM00587.1 - 0.00085 18.2 0.1 0.0078 15.1 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 CCM00587.1 - 0.039 14.4 0.0 0.25 11.8 0.0 2.2 2 1 0 2 2 2 0 Cell division protein FtsA FAT PF02259.23 CCM00588.1 - 8.8e-122 406.6 6.5 8.8e-122 406.6 6.5 2.4 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 CCM00588.1 - 1.5e-68 231.4 0.2 6.3e-68 229.3 0.2 2.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 CCM00588.1 - 1.6e-55 187.5 6.3 1.7e-51 174.3 0.5 5.4 4 1 1 5 5 4 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 CCM00588.1 - 7.1e-39 132.2 0.1 7.1e-39 132.2 0.1 4.6 5 0 0 5 5 4 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 CCM00588.1 - 8.4e-17 61.4 12.5 0.00018 21.8 0.0 10.8 9 2 1 10 10 10 3 HEAT repeats FATC PF02260.20 CCM00588.1 - 6e-15 54.8 0.8 1.6e-14 53.4 0.8 1.8 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 CCM00588.1 - 3.3e-12 45.6 11.1 0.16 12.3 0.0 10.4 8 0 0 8 8 8 1 HEAT repeat TPR_19 PF14559.6 CCM00588.1 - 6e-07 29.9 0.1 0.011 16.2 0.0 4.2 4 0 0 4 4 3 2 Tetratricopeptide repeat HEAT_EZ PF13513.6 CCM00588.1 - 1.6e-06 28.5 20.7 0.0055 17.2 0.1 10.6 12 1 1 13 13 10 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCM00588.1 - 5.6e-06 26.9 0.8 19 5.9 0.0 7.5 7 1 1 8 8 7 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 CCM00588.1 - 1.1e-05 25.2 3.6 1.2 8.7 0.0 5.8 7 0 0 7 7 7 2 CLASP N terminal TPR_7 PF13176.6 CCM00588.1 - 3e-05 23.7 2.7 0.0065 16.4 0.3 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Cnd1 PF12717.7 CCM00588.1 - 0.0019 18.3 9.0 1.6 8.7 0.0 5.9 8 0 0 8 8 7 2 non-SMC mitotic condensation complex subunit 1 TPR_2 PF07719.17 CCM00588.1 - 0.0035 17.4 5.3 4.3 7.7 0.1 4.4 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCM00588.1 - 0.026 14.8 0.3 25 5.2 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM00588.1 - 0.032 14.5 0.5 3.9 7.8 0.0 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 RTP1_C1 PF10363.9 CCM00588.1 - 0.041 14.0 5.5 1.6 8.9 0.0 5.6 7 1 0 7 7 6 0 Required for nuclear transport of RNA pol II C-terminus 1 TAF6_C PF07571.13 CCM00588.1 - 0.059 13.7 1.1 28 5.1 0.0 4.8 6 0 0 6 6 5 0 TAF6 C-terminal HEAT repeat domain TPR_16 PF13432.6 CCM00588.1 - 0.14 12.8 1.0 14 6.4 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat RIX1 PF08167.12 CCM00588.1 - 5.4 6.7 8.3 28 4.4 0.1 5.2 5 0 0 5 5 5 0 rRNA processing/ribosome biogenesis SQS_PSY PF00494.19 CCM00589.1 - 6.6e-28 97.9 0.1 8.8e-28 97.5 0.1 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase RCC1 PF00415.18 CCM00590.1 - 4.6e-38 129.6 16.9 2e-13 50.7 0.2 7.2 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCM00590.1 - 2e-15 56.1 29.6 2.3e-06 27.3 0.2 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat PHD PF00628.29 CCM00590.1 - 1.5e-12 47.2 6.6 1.5e-12 47.2 6.6 2.6 3 0 0 3 3 3 1 PHD-finger ADK_lid PF05191.14 CCM00590.1 - 0.031 14.3 5.5 2.1 8.4 3.4 3.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid C1_1 PF00130.22 CCM00590.1 - 0.099 12.5 0.4 0.099 12.5 0.4 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H PF13771.6 CCM00590.1 - 0.17 12.1 2.2 0.95 9.8 0.1 3.0 3 1 0 3 3 3 0 PHD-like zinc-binding domain zf-RING_2 PF13639.6 CCM00590.1 - 0.3 11.5 8.5 0.21 12.0 5.6 2.3 2 0 0 2 2 2 0 Ring finger domain PHD_4 PF16866.5 CCM00590.1 - 1.4 9.0 8.7 1.8 8.7 5.0 3.1 2 0 0 2 2 2 0 PHD-finger DZR PF12773.7 CCM00590.1 - 2 8.5 7.6 37 4.5 2.9 3.3 2 1 1 3 3 3 0 Double zinc ribbon Prok-RING_1 PF14446.6 CCM00590.1 - 5.9 6.9 10.5 0.31 11.0 4.0 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 InvH PF04741.12 CCM00591.1 - 0.0053 16.7 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 InvH outer membrane lipoprotein F-box-like PF12937.7 CCM00592.1 - 1.2e-08 34.7 0.5 4.7e-08 32.8 0.5 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM00592.1 - 0.019 14.9 0.7 0.019 14.9 0.7 3.3 3 1 0 3 3 3 0 F-box domain DUF2477 PF10631.9 CCM00593.1 - 0.13 12.9 0.2 0.2 12.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Methyltransf_15 PF09445.10 CCM00594.1 - 1.1e-33 116.1 0.0 1.7e-26 92.8 0.0 2.2 2 0 0 2 2 2 2 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CCM00594.1 - 9.8e-08 32.6 0.0 2.6e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CCM00594.1 - 1.3e-06 28.3 0.0 2.4e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.6 CCM00594.1 - 1.3e-06 28.3 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CCM00594.1 - 3.6e-05 23.5 0.0 8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 CCM00594.1 - 0.00018 22.1 0.0 0.00046 20.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 CCM00594.1 - 0.0061 15.6 0.0 0.0085 15.1 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.13 CCM00594.1 - 0.0062 16.0 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 CCM00594.1 - 0.01 15.5 0.0 0.049 13.3 0.0 2.1 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.7 CCM00594.1 - 0.039 13.9 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MRP-S33 PF08293.11 CCM00594.1 - 1.5 9.1 4.6 0.22 11.8 0.2 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal subunit S27 RRM_1 PF00076.22 CCM00595.1 - 6.3e-05 22.7 0.0 0.00014 21.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M28 PF04389.17 CCM00596.1 - 1e-31 110.2 0.0 2e-31 109.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 MFS_1 PF07690.16 CCM00597.1 - 4.8e-21 75.1 32.5 4.8e-21 75.1 32.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 CCM00597.1 - 7.9 4.6 7.9 3.3 5.9 4.6 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) BTB PF00651.31 CCM00598.1 - 0.00024 21.3 0.0 0.00045 20.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF5393 PF17371.2 CCM00598.1 - 0.035 12.2 0.1 0.048 11.8 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5393) FAD_binding_3 PF01494.19 CCM00599.1 - 9e-20 71.2 0.7 1e-18 67.7 0.7 2.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCM00599.1 - 1.1e-05 25.5 2.6 0.00014 22.0 1.6 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM00599.1 - 0.00016 21.4 1.0 0.00043 20.0 1.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM00599.1 - 0.0086 15.3 0.2 0.015 14.5 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCM00599.1 - 0.022 13.6 0.6 0.032 13.1 0.6 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 CCM00599.1 - 0.072 12.3 0.3 0.12 11.6 0.3 1.2 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 CCM00599.1 - 0.15 11.1 3.9 0.24 10.4 3.9 1.3 1 0 0 1 1 1 0 FAD binding domain EphA2_TM PF14575.6 CCM00600.1 - 0.13 13.1 0.0 0.28 12.1 0.0 1.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.10 CCM00601.1 - 0.00099 18.5 4.6 0.0019 17.6 4.6 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CYYR1 PF10873.8 CCM00601.1 - 0.0016 18.9 1.3 0.0016 18.9 1.3 1.7 2 0 0 2 2 2 1 Cysteine and tyrosine-rich protein 1 RCR PF12273.8 CCM00601.1 - 0.0022 18.6 6.8 0.0062 17.2 6.8 1.8 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Adeno_E3_CR2 PF02439.15 CCM00601.1 - 0.011 15.5 6.0 0.025 14.4 6.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM51 PF15345.6 CCM00601.1 - 0.016 15.1 0.2 0.024 14.5 0.2 1.4 1 1 0 1 1 1 0 Transmembrane protein 51 Syndecan PF01034.20 CCM00601.1 - 0.025 14.5 1.8 0.051 13.5 1.8 1.5 1 0 0 1 1 1 0 Syndecan domain DUF2561 PF10812.8 CCM00601.1 - 0.026 14.6 0.4 0.048 13.7 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) Myc_target_1 PF15179.6 CCM00601.1 - 0.037 13.9 0.6 0.037 13.9 0.6 2.2 1 1 2 3 3 3 0 Myc target protein 1 Herpes_gE PF02480.16 CCM00601.1 - 0.037 12.8 0.2 0.052 12.3 0.2 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Amnionless PF14828.6 CCM00601.1 - 0.037 12.9 0.1 0.045 12.6 0.1 1.1 1 0 0 1 1 1 0 Amnionless Sec66 PF09802.9 CCM00601.1 - 0.072 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 EphA2_TM PF14575.6 CCM00601.1 - 0.11 13.4 0.2 0.21 12.5 0.0 1.7 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Tad PF13400.6 CCM00601.1 - 0.11 12.8 2.3 0.18 12.2 2.3 1.4 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like Shisa PF13908.6 CCM00601.1 - 0.39 10.9 1.9 0.55 10.5 0.1 1.8 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator DUF202 PF02656.15 CCM00601.1 - 0.45 11.0 3.3 0.7 10.4 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Pkinase_fungal PF17667.1 CCM00602.1 - 5.7e-42 143.9 0.0 3.3e-23 82.1 0.0 4.1 2 1 0 2 2 2 2 Fungal protein kinase APH PF01636.23 CCM00602.1 - 0.035 14.0 0.0 0.46 10.3 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family NAD_kinase PF01513.21 CCM00603.1 - 8.3e-74 248.4 0.0 1.8e-73 247.3 0.0 1.6 1 1 0 1 1 1 1 ATP-NAD kinase NOA36 PF06524.12 CCM00603.1 - 0.27 10.5 7.3 0.44 9.8 7.3 1.3 1 0 0 1 1 1 0 NOA36 protein Q_salvage PF10343.9 CCM00604.1 - 0.00018 21.2 0.0 0.12 11.9 0.0 2.3 2 0 0 2 2 2 2 Potential Queuosine, Q, salvage protein family HMG_box PF00505.19 CCM00606.1 - 2.9e-12 46.8 3.5 2.9e-12 46.8 3.5 2.4 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM00606.1 - 0.00012 22.6 2.3 0.00012 22.6 2.3 2.3 1 1 1 2 2 2 1 HMG-box domain Pkinase_fungal PF17667.1 CCM00607.1 - 3.2e-42 144.8 0.0 4.1e-27 95.0 0.0 2.4 1 1 1 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 CCM00607.1 - 0.0064 15.9 0.0 0.015 14.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 CCM00607.1 - 0.037 13.9 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family SMP PF04927.12 CCM00608.1 - 0.18 12.3 0.1 0.36 11.3 0.1 1.4 1 0 0 1 1 1 0 Seed maturation protein LRR_4 PF12799.7 CCM00610.1 - 0.13 12.7 1.9 53 4.4 0.1 4.2 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) COesterase PF00135.28 CCM00612.1 - 2e-72 244.7 0.0 3.1e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family ADH_zinc_N PF00107.26 CCM00612.1 - 1.5e-12 47.6 0.0 2.9e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM00612.1 - 2.7e-10 40.1 0.0 6.7e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_3 PF07859.13 CCM00612.1 - 1e-07 32.1 1.3 1.2e-07 31.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM00612.1 - 0.022 14.2 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Peptidase_S10 PF00450.22 CCM00613.1 - 9.8e-99 331.6 0.0 1.2e-98 331.3 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase F-box-like PF12937.7 CCM00615.1 - 0.00013 21.8 0.0 0.00082 19.2 0.0 2.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM00615.1 - 0.0025 17.6 0.3 0.95 9.4 0.0 4.4 4 1 0 4 4 4 1 F-box domain zf-RING_2 PF13639.6 CCM00616.1 - 9.7e-13 48.2 3.4 1.5e-12 47.6 3.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CCM00616.1 - 2.5e-09 36.7 1.0 4.5e-09 35.9 1.0 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCM00616.1 - 4.3e-09 36.1 2.6 6.6e-09 35.5 2.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM00616.1 - 1.6e-07 31.1 1.8 2.5e-07 30.4 1.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCM00616.1 - 1.7e-07 31.4 4.3 3.2e-07 30.5 4.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CCM00616.1 - 2.8e-06 27.2 2.4 4.3e-06 26.6 2.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CCM00616.1 - 3.5e-06 26.8 2.1 5.1e-06 26.2 2.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM00616.1 - 0.00041 20.3 0.6 0.0008 19.4 0.6 1.4 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CCM00616.1 - 0.00071 19.4 2.4 0.0012 18.6 2.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CCM00616.1 - 0.00093 19.2 1.4 0.0017 18.4 1.4 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 CCM00616.1 - 0.017 14.7 2.1 0.03 13.9 2.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 CCM00616.1 - 0.051 13.9 1.9 0.091 13.1 1.9 1.3 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 CCM00616.1 - 0.13 12.1 4.4 0.25 11.2 4.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 CCM00616.1 - 0.29 11.2 0.9 0.58 10.2 0.9 1.4 1 0 0 1 1 1 0 Zinc-finger zf-HC5HC2H_2 PF13832.6 CCM00616.1 - 0.34 11.1 1.9 0.66 10.2 1.9 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain RINGv PF12906.7 CCM00616.1 - 0.39 10.9 4.2 0.68 10.1 4.2 1.4 1 0 0 1 1 1 0 RING-variant domain DUF3158 PF11358.8 CCM00617.1 - 0.048 13.4 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3158) Melibiase_2 PF16499.5 CCM00618.1 - 9.9e-56 189.0 0.3 2.3e-55 187.8 0.5 1.4 2 0 0 2 2 2 1 Alpha galactosidase A Melibiase_C PF17801.1 CCM00618.1 - 5.2e-16 58.5 0.0 1.1e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 CCM00618.1 - 0.0054 15.7 0.0 0.0082 15.1 0.0 1.2 1 0 0 1 1 1 1 Melibiase AMP-binding PF00501.28 CCM00619.1 - 6e-82 275.5 0.0 7.6e-82 275.1 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM00619.1 - 1.8e-15 57.7 0.2 6.1e-15 56.0 0.2 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain p450 PF00067.22 CCM00620.1 - 7.3e-47 160.2 0.0 7.1e-43 147.0 0.0 2.4 2 1 0 2 2 2 2 Cytochrome P450 Stealth_CR2 PF11380.8 CCM00622.1 - 7e-17 61.6 0.1 4.7e-12 46.0 0.0 2.5 2 0 0 2 2 2 2 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 CCM00622.1 - 1e-13 51.0 2.9 2e-13 50.0 2.9 1.6 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 CCM00622.1 - 0.011 15.6 0.0 0.039 13.8 0.0 2.0 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Stealth_CR1 PF17101.5 CCM00622.1 - 0.014 15.1 0.1 0.033 13.9 0.1 1.6 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 FIST PF08495.10 CCM00623.1 - 2.2e-08 34.3 0.0 3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 FIST N domain Peptidase_M20 PF01546.28 CCM00624.1 - 2.5e-25 89.4 0.0 2.3e-24 86.2 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 CCM00624.1 - 1.6e-13 50.8 5.7 2e-05 25.2 0.0 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat M20_dimer PF07687.14 CCM00624.1 - 1.6e-11 44.0 0.0 3.1e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Nup160 PF11715.8 CCM00624.1 - 3e-05 22.9 0.1 0.062 11.9 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 VID27 PF08553.10 CCM00624.1 - 0.25 10.4 0.0 0.37 9.8 0.0 1.1 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain ABC_tran PF00005.27 CCM00626.1 - 2e-29 102.8 0.1 3.5e-29 102.1 0.1 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCM00626.1 - 1.1e-05 24.9 1.1 0.0086 15.5 0.1 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCM00626.1 - 0.002 18.5 0.4 0.0034 17.8 0.4 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CCM00626.1 - 0.0033 17.3 0.2 2.1 8.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 CCM00626.1 - 0.0088 16.2 0.1 0.019 15.1 0.1 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 CCM00626.1 - 0.013 15.6 0.0 0.033 14.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 CCM00626.1 - 0.021 14.4 0.1 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCM00626.1 - 0.032 14.0 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.29 CCM00626.1 - 0.033 14.0 0.1 0.11 12.2 0.1 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase IstB_IS21 PF01695.17 CCM00626.1 - 0.059 13.1 0.1 0.6 9.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 CCM00626.1 - 0.19 11.6 0.9 12 5.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 CCM00626.1 - 0.26 11.6 1.1 2.8 8.2 1.1 2.2 1 1 0 1 1 1 0 AAA domain AP_endonuc_2 PF01261.24 CCM00629.1 - 4e-22 78.7 0.0 6.7e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel TENA_THI-4 PF03070.16 CCM00630.1 - 0.009 15.8 0.1 0.035 13.9 0.1 1.9 1 1 0 1 1 1 1 TENA/THI-4/PQQC family Kelch_3 PF13415.6 CCM00631.1 - 5.4e-28 96.7 5.5 5.8e-07 29.7 0.1 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 CCM00631.1 - 1.1e-27 95.8 8.1 3.1e-06 27.1 0.0 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 CCM00631.1 - 1.1e-19 69.9 5.1 1.6e-06 28.2 0.0 4.6 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 CCM00631.1 - 5.6e-19 67.5 5.8 1.7e-05 24.3 0.0 5.1 4 1 0 4 4 4 4 Kelch motif DUF4110 PF13422.6 CCM00631.1 - 8.2e-17 61.1 0.0 8.2e-17 61.1 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4110) Kelch_5 PF13854.6 CCM00631.1 - 7.6e-14 51.3 9.4 0.00022 21.1 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 CCM00631.1 - 5.9e-13 48.2 9.7 8.3e-05 22.4 0.1 5.7 5 1 0 5 5 5 3 Kelch motif NARP1 PF12569.8 CCM00631.1 - 8.9 5.1 9.8 16 4.2 9.8 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CPBP PF02517.16 CCM00632.1 - 6.4e-07 29.7 1.3 6.4e-07 29.7 1.3 2.3 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease TENA_THI-4 PF03070.16 CCM00634.1 - 7.7e-07 29.1 0.2 3.6e-06 26.9 0.2 2.0 1 1 0 1 1 1 1 TENA/THI-4/PQQC family GST_N_2 PF13409.6 CCM00635.1 - 9e-23 80.4 0.0 2.2e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM00635.1 - 1.6e-14 53.6 0.0 3.1e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCM00635.1 - 3.7e-10 39.9 0.0 6.9e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCM00635.1 - 4.7e-05 23.5 0.0 9.8e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCM00635.1 - 7.3e-05 23.1 0.0 0.0021 18.5 0.0 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Sporozoite_P67 PF05642.11 CCM00636.1 - 0.2 9.7 3.6 0.22 9.6 3.6 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ubiquitin PF00240.23 CCM00638.1 - 1e-16 60.4 0.0 1.6e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCM00638.1 - 5.1e-08 32.6 0.0 7.4e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Blt1 PF12754.7 CCM00638.1 - 0.00016 22.0 0.7 0.00027 21.3 0.7 1.4 1 0 0 1 1 1 1 Blt1 N-terminal domain Ubiquitin_2 PF14560.6 CCM00638.1 - 0.005 17.3 0.0 0.015 15.7 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain CHCH PF06747.13 CCM00639.1 - 0.0011 19.0 3.5 0.0017 18.5 3.5 1.3 1 0 0 1 1 1 1 CHCH domain Ndufs5 PF10200.9 CCM00639.1 - 0.0022 18.2 0.3 0.0027 17.9 0.3 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Cmc1 PF08583.10 CCM00639.1 - 0.009 16.0 0.9 0.014 15.4 0.9 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like PADR1 PF08063.12 CCM00639.1 - 0.023 14.5 1.6 4.6 7.1 0.0 2.6 2 1 1 3 3 3 0 PADR1 (NUC008) domain DUF3128 PF11326.8 CCM00639.1 - 0.029 14.7 2.3 0.088 13.2 2.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) PX PF00787.24 CCM00641.1 - 1.5e-19 70.0 0.0 2.8e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.9 CCM00641.1 - 5.5e-12 45.6 0.6 5.3e-11 42.4 0.7 2.0 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein malic PF00390.19 CCM00643.1 - 3.2e-20 72.7 0.0 4.1e-20 72.3 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 CCM00644.1 - 3.7e-90 301.7 0.0 4.6e-90 301.4 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CCM00644.1 - 3.4e-29 101.9 0.0 5.3e-29 101.3 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Acyl-CoA_dh_1 PF00441.24 CCM00645.1 - 5.2e-07 30.0 0.2 5.2e-07 30.0 0.2 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_C PF12806.7 CCM00645.1 - 0.082 13.1 2.1 0.27 11.4 1.7 2.1 1 1 1 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like MFS_1 PF07690.16 CCM00646.1 - 6.8e-39 133.8 56.6 3.7e-31 108.3 15.8 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 CCM00646.1 - 4.4e-06 25.4 8.6 4.4e-06 25.4 8.6 2.0 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM00646.1 - 1.7e-05 23.9 10.0 1.7e-05 23.9 10.0 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter NDUF_B12 PF08122.12 CCM00646.1 - 0.039 14.0 5.5 0.34 11.0 0.1 4.4 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase B12 subunit family Tam41_Mmp37 PF09139.11 CCM00647.1 - 3.6e-114 381.5 0.0 4.2e-114 381.3 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Nas2_N PF18265.1 CCM00648.1 - 4e-24 84.3 0.0 5.3e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 CCM00648.1 - 0.00023 20.9 0.1 0.00063 19.5 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CCM00648.1 - 0.0046 17.2 0.0 0.03 14.7 0.0 2.2 2 0 0 2 2 2 1 PDZ domain DUF5475 PF17569.2 CCM00648.1 - 0.025 14.9 0.0 0.049 14.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5475) NDK PF00334.19 CCM00649.1 - 5.1e-17 62.1 0.0 1.1e-16 61.1 0.0 1.5 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Thi4 PF01946.17 CCM00650.1 - 3.6e-103 343.9 0.4 4.3e-103 343.6 0.4 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCM00650.1 - 1e-09 38.4 3.2 1.8e-09 37.6 1.3 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM00650.1 - 5.4e-08 32.3 0.9 2.3e-07 30.2 0.3 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCM00650.1 - 1.2e-07 31.8 0.1 3e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM00650.1 - 2.9e-07 30.0 0.0 4.5e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM00650.1 - 1.4e-06 27.7 1.5 1.3e-05 24.4 0.4 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCM00650.1 - 3.1e-06 27.3 0.5 7.9e-05 22.7 0.1 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 CCM00650.1 - 7.4e-05 21.6 0.6 0.00016 20.5 0.4 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 CCM00650.1 - 0.00024 20.6 0.3 0.00039 19.9 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CCM00650.1 - 0.00081 18.6 0.3 0.019 14.0 0.3 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CCM00650.1 - 0.0018 17.6 0.8 0.0036 16.6 0.3 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM00650.1 - 0.032 14.8 0.2 0.081 13.5 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CCM00650.1 - 0.035 13.4 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 CCM00650.1 - 0.054 12.3 0.3 0.08 11.8 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase GMC_oxred_N PF00732.19 CCM00650.1 - 0.07 12.5 0.1 0.87 8.9 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase K_oxygenase PF13434.6 CCM00650.1 - 0.13 11.4 0.0 0.27 10.3 0.0 1.5 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) CM_2 PF01817.21 CCM00651.1 - 5.5e-05 23.4 0.0 0.065 13.6 0.0 2.5 2 0 0 2 2 2 2 Chorismate mutase type II Septin PF00735.18 CCM00652.1 - 5.9e-45 153.7 0.0 2.5e-17 63.1 0.0 3.9 4 0 0 4 4 4 3 Septin MMR_HSR1 PF01926.23 CCM00652.1 - 0.00022 21.3 0.0 0.00043 20.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCM00652.1 - 0.0014 18.2 0.0 0.003 17.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCM00652.1 - 0.0056 17.1 0.1 0.024 15.0 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCM00652.1 - 0.012 15.9 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCM00652.1 - 0.022 15.0 0.3 0.087 13.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain zf-H2C2_5 PF13909.6 CCM00652.1 - 0.023 14.5 0.1 0.054 13.3 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Dynamin_N PF00350.23 CCM00652.1 - 0.046 13.8 0.3 3.3 7.8 0.1 2.4 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 CCM00652.1 - 0.087 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase tRNA_synthFbeta PF17759.1 CCM00652.1 - 0.14 11.6 0.0 0.37 10.2 0.0 1.7 1 0 0 1 1 1 0 Phenylalanyl tRNA synthetase beta chain CLM domain Septin PF00735.18 CCM00653.1 - 4.8e-29 101.5 0.0 5.6e-10 39.0 0.0 3.2 3 0 0 3 3 3 3 Septin Zn_clus PF00172.18 CCM00653.1 - 1.9e-09 37.5 11.8 3.2e-09 36.7 11.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATG27 PF09451.10 CCM00653.1 - 0.13 12.1 1.7 0.2 11.5 1.7 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 PPR_2 PF13041.6 CCM00654.1 - 3.1e-43 145.7 0.0 7.5e-10 38.9 0.0 10.1 7 3 3 11 11 11 7 PPR repeat family PPR PF01535.20 CCM00654.1 - 5.2e-35 117.2 0.1 0.012 15.8 0.0 14.6 15 0 0 15 15 15 7 PPR repeat PPR_3 PF13812.6 CCM00654.1 - 2.3e-30 104.4 0.0 2.3e-08 34.0 0.0 7.5 5 2 2 8 8 7 5 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCM00654.1 - 2e-18 65.8 0.0 0.013 15.2 0.0 9.4 11 0 0 11 11 11 4 PPR repeat PPR_long PF17177.4 CCM00654.1 - 2.4e-13 49.9 0.1 0.00011 21.7 0.0 4.6 2 1 3 5 5 5 5 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 CCM00654.1 - 4.9e-09 36.3 4.5 2.4 9.2 0.0 7.7 6 1 1 7 7 6 1 Tetratricopeptide repeat ATP13 PF12921.7 CCM00654.1 - 3.6e-05 23.6 0.0 3.5 7.5 0.0 4.8 3 1 1 4 4 4 1 Mitochondrial ATPase expression DUF3368 PF11848.8 CCM00654.1 - 0.0017 18.1 0.4 37 4.2 0.0 5.6 6 0 0 6 6 6 0 Domain of unknown function (DUF3368) TPR_19 PF14559.6 CCM00654.1 - 0.0038 17.7 0.8 2.3 8.8 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat Clathrin PF00637.20 CCM00654.1 - 0.01 15.7 0.0 1.5 8.7 0.0 3.4 3 0 0 3 3 3 1 Region in Clathrin and VPS TPR_16 PF13432.6 CCM00654.1 - 0.025 15.2 2.0 4.7 7.9 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat B12-binding_2 PF02607.17 CCM00654.1 - 0.066 13.7 0.3 1.9e+02 2.6 0.0 5.0 4 1 1 5 5 5 0 B12 binding domain TPR_6 PF13174.6 CCM00654.1 - 0.089 13.5 0.6 1.7 9.4 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCM00654.1 - 0.88 9.9 5.7 11 6.4 0.0 4.3 5 1 1 6 6 5 0 Tetratricopeptide repeat Velvet PF11754.8 CCM00655.1 - 1.5e-78 264.2 11.1 1.1e-48 166.4 10.9 3.5 2 1 0 2 2 2 2 Velvet factor ArfGap PF01412.18 CCM00656.1 - 2e-28 98.8 0.0 3.5e-28 98.0 0.0 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf F-box PF00646.33 CCM00657.1 - 1.1e-05 25.2 0.3 3e-05 23.8 0.3 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCM00657.1 - 0.00053 19.8 1.0 0.00053 19.8 1.0 2.5 4 0 0 4 4 4 1 F-box-like F-box_4 PF15966.5 CCM00657.1 - 0.0016 18.3 0.1 0.0036 17.2 0.1 1.6 1 0 0 1 1 1 1 F-box UCH PF00443.29 CCM00658.1 - 1.8e-46 158.7 0.0 3.6e-46 157.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM00658.1 - 7.3e-19 68.5 1.6 1.6e-18 67.4 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-C2H2 PF00096.26 CCM00658.1 - 2.4e-06 27.7 44.3 0.0033 17.8 0.9 6.4 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM00658.1 - 9.4e-06 25.8 28.1 0.0063 16.9 3.3 6.0 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCM00658.1 - 0.00022 21.8 36.7 0.0046 17.7 0.7 6.1 5 0 0 5 5 5 2 C2H2-type zinc finger zf-met PF12874.7 CCM00658.1 - 0.12 12.8 28.2 0.22 12.0 1.0 4.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type DUF2175 PF09943.9 CCM00658.1 - 0.13 12.6 2.0 0.38 11.1 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-C2H2_jaz PF12171.8 CCM00658.1 - 0.42 10.9 26.7 0.18 12.1 0.5 4.8 4 1 1 5 5 5 0 Zinc-finger double-stranded RNA-binding Yippee-Mis18 PF03226.14 CCM00658.1 - 0.63 10.3 6.3 0.79 10.0 1.9 2.9 3 0 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PP2C PF00481.21 CCM00659.1 - 6.8e-27 94.7 0.0 1.7e-24 86.9 0.0 2.7 2 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CCM00659.1 - 0.011 15.4 0.0 0.035 13.7 0.0 1.8 1 1 0 1 1 1 0 Protein phosphatase 2C Yip1 PF04893.17 CCM00661.1 - 0.00019 21.2 0.8 0.0003 20.6 0.8 1.3 1 0 0 1 1 1 1 Yip1 domain Haspin_kinase PF12330.8 CCM00662.1 - 3.2e-59 200.7 0.0 4.8e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain DUF4106 PF13388.6 CCM00662.1 - 0.22 10.7 1.3 0.53 9.5 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Sld5 PF05916.11 CCM00663.1 - 5e-24 84.9 0.2 8.1e-24 84.2 0.2 1.3 1 0 0 1 1 1 1 GINS complex protein Ion_trans PF00520.31 CCM00664.1 - 1e-05 24.9 10.8 2.3e-05 23.7 10.8 1.6 1 0 0 1 1 1 1 Ion transport protein P21-Arc PF04062.14 CCM00665.1 - 5.2e-75 251.3 0.0 5.8e-75 251.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit NOB1_Zn_bind PF08772.11 CCM00666.1 - 1.2e-29 102.2 0.3 2e-29 101.5 0.3 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 CCM00666.1 - 1.7e-28 99.0 0.0 2.8e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 PIN domain of ribonuclease zf-NADH-PPase PF09297.11 CCM00666.1 - 0.21 11.3 1.9 4.6 7.0 0.3 2.7 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Iso_dh PF00180.20 CCM00667.1 - 6.5e-122 407.0 0.0 7.6e-122 406.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Vps5 PF09325.10 CCM00668.1 - 8.8e-16 58.2 1.0 1.2e-15 57.7 1.0 1.1 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CCM00668.1 - 1.1e-10 41.5 0.1 2.4e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 PX domain PI3K_P85_iSH2 PF16454.5 CCM00668.1 - 1.7 8.3 4.7 3.6 7.2 4.7 1.5 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GTP_cyclohydro2 PF00925.20 CCM00669.1 - 6.2e-62 208.0 0.0 1.4e-61 206.8 0.0 1.5 1 1 0 1 1 1 1 GTP cyclohydrolase II DUF997 PF06196.12 CCM00671.1 - 0.066 13.2 0.7 0.17 11.9 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF997) TFR_dimer PF04253.15 CCM00672.1 - 1.7e-17 63.6 0.0 1.1e-16 61.0 0.0 2.4 1 1 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 CCM00672.1 - 2.3e-17 63.3 0.0 1.2e-16 61.0 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCM00672.1 - 4.5e-10 39.4 0.4 1e-09 38.3 0.4 1.6 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 CCM00672.1 - 0.021 14.3 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Nicastrin Peptidase_M20 PF01546.28 CCM00672.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 MFS_1 PF07690.16 CCM00673.1 - 4.9e-42 144.1 54.1 4.9e-42 144.1 54.1 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM00673.1 - 4.9e-17 61.9 8.7 4.9e-17 61.9 8.7 2.9 2 1 1 3 3 3 2 Sugar (and other) transporter SKN1 PF03935.15 CCM00674.1 - 2.1e-181 603.7 1.6 2.4e-181 603.5 1.6 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) MFS_1 PF07690.16 CCM00675.1 - 7.2e-17 61.3 51.8 1.8e-12 46.8 10.8 3.1 3 1 0 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM00675.1 - 2.7e-07 29.8 22.3 4.6e-07 29.1 4.2 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter Pex14_N PF04695.13 CCM00676.1 - 3.9e-12 47.1 0.1 3.9e-12 47.1 0.1 3.1 3 1 1 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region adh_short PF00106.25 CCM00677.1 - 1.3e-17 63.9 0.0 1.7e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00677.1 - 1.6e-07 31.1 0.0 2.1e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM00677.1 - 2.9e-05 24.1 0.0 0.00011 22.2 0.0 1.8 1 1 0 1 1 1 1 KR domain RXLR_WY PF18634.1 CCM00677.1 - 0.25 11.3 0.2 2.3 8.2 0.0 2.2 2 0 0 2 2 2 0 RXLR phytopathogen effector protein WY-domain ACT_7 PF13840.6 CCM00678.1 - 2.3e-20 72.1 0.0 1.5e-13 50.3 0.1 2.4 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CCM00678.1 - 0.019 14.7 0.0 1.2 8.9 0.0 2.7 2 0 0 2 2 2 0 ACT domain Ribosomal_L30 PF00327.20 CCM00679.1 - 0.036 13.9 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein L30p/L7e adh_short PF00106.25 CCM00681.1 - 1.2e-41 142.3 0.2 1.8e-41 141.7 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00681.1 - 5.1e-28 98.2 0.0 7.6e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM00681.1 - 2.9e-12 46.8 1.2 5.6e-11 42.7 1.2 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM00681.1 - 0.12 11.8 0.1 0.27 10.7 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Asparaginase_2 PF01112.18 CCM00684.1 - 1.3e-75 254.3 0.0 7.2e-56 189.4 0.0 2.2 2 0 0 2 2 2 2 Asparaginase Glyco_hydro_10 PF00331.20 CCM00685.1 - 2.6e-96 322.5 0.0 3e-96 322.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 YolD PF08863.10 CCM00685.1 - 0.2 11.7 0.0 0.38 10.8 0.0 1.4 1 0 0 1 1 1 0 YolD-like protein GST_N_3 PF13417.6 CCM00686.1 - 6.1e-13 49.0 0.0 1.4e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM00686.1 - 8.7e-13 48.4 0.0 2.4e-12 46.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM00686.1 - 0.00062 19.7 0.7 0.001 19.1 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCM00686.1 - 0.0051 17.1 0.0 0.12 12.8 0.0 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 CCM00686.1 - 0.033 14.5 0.0 0.058 13.7 0.0 1.3 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein GST_C PF00043.25 CCM00686.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glyco_hydro_10 PF00331.20 CCM00687.1 - 2e-100 336.0 0.0 2.3e-100 335.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 DUF1615 PF07759.12 CCM00687.1 - 0.016 14.5 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) Glyco_hydro_10 PF00331.20 CCM00688.1 - 7.1e-76 255.4 0.0 3.6e-61 207.1 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 10 Abhydrolase_6 PF12697.7 CCM00689.1 - 3.9e-09 37.4 3.1 5.1e-09 37.1 3.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 CCM00689.1 - 0.0082 15.1 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 CCM00689.1 - 0.048 13.3 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Dynamitin PF04912.14 CCM00690.1 - 2.8e-70 237.6 2.3 2.8e-70 237.6 2.3 1.9 2 0 0 2 2 2 1 Dynamitin Apolipoprotein PF01442.18 CCM00690.1 - 1.7e-07 31.3 7.6 1.7e-07 31.3 7.6 2.8 3 1 0 3 3 2 1 Apolipoprotein A1/A4/E domain Fib_alpha PF08702.10 CCM00690.1 - 0.00044 20.5 0.3 0.00044 20.5 0.3 2.3 3 0 0 3 3 1 1 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 CCM00690.1 - 0.00062 19.8 0.2 0.55 10.3 0.0 3.7 3 1 1 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 CCM00690.1 - 0.0011 19.4 3.4 3.1 8.3 0.4 4.7 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein PhaP_Bmeg PF09602.10 CCM00690.1 - 0.0014 18.6 2.4 0.004 17.1 1.3 2.3 2 1 0 2 2 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) JAKMIP_CC3 PF16034.5 CCM00690.1 - 0.0015 18.5 0.4 0.047 13.6 0.1 2.4 2 0 0 2 2 2 1 JAKMIP CC3 domain Fmp27_WPPW PF10359.9 CCM00690.1 - 0.0037 16.2 1.5 1.6 7.5 0.3 2.3 2 0 0 2 2 2 2 RNA pol II promoter Fmp27 protein domain YPEB PF14620.6 CCM00690.1 - 0.004 16.5 1.1 0.07 12.5 0.3 2.3 2 0 0 2 2 2 1 YpeB sporulation DUF1664 PF07889.12 CCM00690.1 - 0.0056 16.7 1.7 0.0056 16.7 1.7 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 CCM00690.1 - 0.0079 16.3 16.5 0.017 15.2 7.1 3.1 3 1 0 3 3 2 1 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 CCM00690.1 - 0.01 15.1 1.1 0.25 10.5 0.5 2.2 2 0 0 2 2 2 0 TMPIT-like protein DUF3584 PF12128.8 CCM00690.1 - 0.012 13.2 1.8 0.018 12.6 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF1319 PF07028.11 CCM00690.1 - 0.019 15.2 2.1 0.019 15.2 2.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) OmpH PF03938.14 CCM00690.1 - 0.034 14.5 3.2 0.3 11.4 1.2 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Prominin PF05478.11 CCM00690.1 - 0.036 12.0 0.1 0.055 11.4 0.1 1.3 1 0 0 1 1 1 0 Prominin ABC_tran_CTD PF16326.5 CCM00690.1 - 0.042 14.1 7.7 5.2 7.4 0.1 3.5 3 1 0 3 3 2 0 ABC transporter C-terminal domain PspA_IM30 PF04012.12 CCM00690.1 - 0.057 13.0 9.8 0.45 10.1 1.6 3.6 2 1 1 3 3 3 0 PspA/IM30 family ApoLp-III PF07464.11 CCM00690.1 - 0.059 13.5 1.8 0.23 11.5 0.9 2.2 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) FlaC_arch PF05377.11 CCM00690.1 - 0.061 13.7 13.5 1.6 9.2 3.8 5.1 4 1 1 6 6 5 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.20 CCM00690.1 - 0.075 13.0 6.6 61 3.6 7.3 3.8 3 1 0 3 3 3 0 Prefoldin subunit Spc7 PF08317.11 CCM00690.1 - 0.078 11.8 12.5 0.0083 15.0 5.7 2.2 2 1 0 2 2 2 0 Spc7 kinetochore protein BshC PF10079.9 CCM00690.1 - 0.078 11.7 0.1 0.13 10.9 0.1 1.3 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Swi5 PF07061.11 CCM00690.1 - 0.083 13.0 4.2 4.7 7.4 1.7 3.3 2 1 0 2 2 2 0 Swi5 Laminin_II PF06009.12 CCM00690.1 - 0.14 12.2 11.0 0.092 12.8 3.1 3.6 4 1 0 4 4 3 0 Laminin Domain II DUF724 PF05266.14 CCM00690.1 - 0.18 11.6 5.8 0.23 11.3 2.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) SLATT_fungal PF18142.1 CCM00690.1 - 0.19 11.7 0.6 0.51 10.3 0.1 2.0 3 0 0 3 3 1 0 SMODS and SLOG-associating 2TM effector domain FlgN PF05130.12 CCM00690.1 - 0.27 11.7 3.7 1.2 9.7 0.7 2.6 3 0 0 3 3 2 0 FlgN protein HMMR_N PF15905.5 CCM00690.1 - 0.27 10.7 8.7 0.04 13.4 4.0 1.9 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal GAS PF13851.6 CCM00690.1 - 0.34 10.2 6.4 0.36 10.2 2.8 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding HSBP1 PF06825.12 CCM00690.1 - 0.34 10.8 3.5 15 5.5 0.0 3.8 3 1 1 4 4 3 0 Heat shock factor binding protein 1 Fez1 PF06818.15 CCM00690.1 - 0.35 11.3 8.5 2.5 8.5 3.8 2.5 2 0 0 2 2 2 0 Fez1 Merozoite_SPAM PF07133.11 CCM00690.1 - 0.36 10.8 9.6 0.84 9.6 9.6 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) APG6_N PF17675.1 CCM00690.1 - 0.37 11.3 9.9 0.25 11.9 1.4 2.8 2 1 0 2 2 2 0 Apg6 coiled-coil region IMD PF08397.11 CCM00690.1 - 0.38 10.1 3.6 0.89 8.9 1.6 2.4 2 0 0 2 2 2 0 IRSp53/MIM homology domain CENP-H PF05837.12 CCM00690.1 - 0.4 11.1 6.5 0.5 10.8 1.4 2.9 3 0 0 3 3 2 0 Centromere protein H (CENP-H) DUF3450 PF11932.8 CCM00690.1 - 0.4 9.9 6.1 0.11 11.8 1.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) TolA_bind_tri PF16331.5 CCM00690.1 - 0.41 10.8 13.1 4.3 7.5 1.5 4.8 3 2 1 4 4 4 0 TolA binding protein trimerisation Noelin-1 PF12308.8 CCM00690.1 - 0.53 10.3 4.1 0.6 10.1 0.5 3.0 3 1 0 3 3 1 0 Neurogenesis glycoprotein CorA PF01544.18 CCM00690.1 - 0.55 9.5 11.7 0.84 8.9 3.7 3.1 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.15 CCM00690.1 - 0.63 9.6 4.0 15 5.0 4.0 2.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit AAA_13 PF13166.6 CCM00690.1 - 0.65 8.6 4.3 0.79 8.3 1.6 2.2 2 1 0 2 2 2 0 AAA domain SKA2 PF16740.5 CCM00690.1 - 0.71 9.7 4.9 21 5.0 0.1 3.3 2 2 1 3 3 3 0 Spindle and kinetochore-associated protein 2 Cep57_MT_bd PF06657.13 CCM00690.1 - 0.72 10.3 9.0 6.2 7.4 1.4 3.1 3 0 0 3 3 2 0 Centrosome microtubule-binding domain of Cep57 MPS2 PF17060.5 CCM00690.1 - 0.78 8.9 7.0 0.75 9.0 0.4 2.2 2 0 0 2 2 2 0 Monopolar spindle protein 2 MIP-T3_C PF17749.1 CCM00690.1 - 0.82 9.6 7.3 0.3 11.0 1.6 3.0 2 2 2 4 4 4 0 Microtubule-binding protein MIP-T3 C-terminal region SlyX PF04102.12 CCM00690.1 - 0.86 10.3 13.3 58 4.4 3.5 5.0 4 1 0 4 4 3 0 SlyX DUF948 PF06103.11 CCM00690.1 - 0.87 9.9 6.7 5.1 7.4 2.3 3.9 4 1 0 4 4 2 0 Bacterial protein of unknown function (DUF948) WXG100 PF06013.12 CCM00690.1 - 0.89 9.8 3.8 1.5 9.1 0.8 2.9 3 0 0 3 3 2 0 Proteins of 100 residues with WXG Golgin_A5 PF09787.9 CCM00690.1 - 1 8.8 7.5 0.11 11.9 1.1 2.3 2 1 0 2 2 2 0 Golgin subfamily A member 5 Rootletin PF15035.6 CCM00690.1 - 1.1 9.3 7.8 2.3 8.2 3.8 2.4 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Syntaxin-6_N PF09177.11 CCM00690.1 - 1.1 9.8 10.5 1.2 9.7 2.9 3.6 3 2 1 4 4 3 0 Syntaxin 6, N-terminal HalX PF08663.10 CCM00690.1 - 1.2 9.5 15.2 6.9 7.1 0.7 3.9 2 1 1 3 3 3 0 HalX domain DUF4208 PF13907.6 CCM00690.1 - 1.2 9.6 2.8 2.4 8.6 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) CENP-F_leu_zip PF10473.9 CCM00690.1 - 1.8 8.6 17.1 13 5.8 0.3 3.9 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CREPT PF16566.5 CCM00690.1 - 2.3 8.4 7.4 4.4 7.5 0.0 3.4 3 1 0 3 3 2 0 Cell-cycle alteration and expression-elevated protein in tumour Spc24 PF08286.11 CCM00690.1 - 2.3 8.5 7.1 31 4.9 3.8 2.8 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 CENP-Q PF13094.6 CCM00690.1 - 2.3 8.4 13.9 0.2 11.9 4.1 2.8 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Macoilin PF09726.9 CCM00690.1 - 2.4 6.6 10.1 3.3 6.2 5.2 2.2 2 0 0 2 2 2 0 Macoilin family COG2 PF06148.11 CCM00690.1 - 3.9 7.6 9.7 7.9 6.6 4.9 3.0 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Helo_like_N PF17111.5 CCM00690.1 - 4.5 6.6 6.1 16 4.8 0.7 3.2 2 1 1 3 3 3 0 Fungal N-terminal domain of STAND proteins CLZ PF16526.5 CCM00690.1 - 4.6 7.7 11.4 27 5.2 5.2 3.9 4 1 0 4 4 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels dsrm PF00035.26 CCM00691.1 - 0.0077 16.9 0.0 0.0095 16.6 0.0 1.2 1 0 0 1 1 1 1 Double-stranded RNA binding motif Chitin_synth_2 PF03142.15 CCM00692.1 - 2.8e-228 758.8 0.0 4e-228 758.3 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 CCM00692.1 - 1.9e-08 34.5 0.0 1e-06 28.9 0.0 2.7 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CCM00692.1 - 1.9e-08 34.4 14.6 2.7e-08 34.0 7.8 3.2 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.28 CCM00692.1 - 0.014 15.5 0.0 0.7 10.1 0.0 2.8 2 1 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 CCM00692.1 - 0.045 13.6 0.0 3.8 7.3 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 DSPc PF00782.20 CCM00693.1 - 2.4e-05 24.1 0.0 5.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 CCM00693.1 - 0.0013 18.5 0.4 0.003 17.3 0.4 1.6 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 CCM00693.1 - 0.017 15.3 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 CCM00693.1 - 0.063 12.8 2.4 0.25 10.9 0.0 2.6 3 0 0 3 3 3 0 Protein-tyrosine phosphatase Abhydrolase_6 PF12697.7 CCM00694.1 - 5.4e-05 23.9 0.3 6.7e-05 23.6 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCM00694.1 - 0.1 12.2 0.0 0.36 10.4 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold TPR_2 PF07719.17 CCM00695.1 - 5.8e-33 110.3 37.0 1.2e-06 28.2 0.6 18.0 17 0 0 17 17 17 7 Tetratricopeptide repeat TPR_16 PF13432.6 CCM00695.1 - 7.1e-30 103.4 63.2 1.1e-08 35.6 0.9 12.5 12 1 2 14 14 12 7 Tetratricopeptide repeat TPR_1 PF00515.28 CCM00695.1 - 7.4e-27 92.0 25.9 6.1e-07 29.0 0.1 14.6 15 0 0 15 15 15 6 Tetratricopeptide repeat TPR_8 PF13181.6 CCM00695.1 - 3.1e-26 89.3 20.5 0.00067 19.7 0.1 15.8 16 0 0 16 16 15 4 Tetratricopeptide repeat TPR_19 PF14559.6 CCM00695.1 - 4e-26 91.3 45.6 5.7e-05 23.6 1.7 12.5 10 3 3 13 13 12 6 Tetratricopeptide repeat TPR_14 PF13428.6 CCM00695.1 - 9.2e-26 88.3 67.5 0.00039 21.0 1.7 19.7 15 5 6 21 21 19 6 Tetratricopeptide repeat TPR_17 PF13431.6 CCM00695.1 - 2e-17 62.2 3.9 2.8 8.5 0.1 14.6 16 1 0 16 16 13 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCM00695.1 - 3.8e-12 46.2 29.2 0.00021 21.4 0.1 10.4 9 1 2 11 11 11 4 Tetratricopeptide repeat TPR_11 PF13414.6 CCM00695.1 - 3.8e-11 42.5 34.4 0.015 15.0 0.3 12.8 10 3 5 15 15 14 5 TPR repeat TPR_12 PF13424.6 CCM00695.1 - 4.4e-11 42.9 50.3 0.00094 19.4 0.6 13.9 13 4 2 15 15 13 4 Tetratricopeptide repeat TPR_6 PF13174.6 CCM00695.1 - 1.6e-10 41.0 28.1 0.025 15.2 0.3 13.0 14 0 0 14 14 12 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM00695.1 - 5.1e-10 39.4 11.4 0.039 14.2 0.0 8.6 7 3 3 10 10 10 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CCM00695.1 - 2.7e-06 27.0 29.2 0.028 14.4 0.2 10.9 14 0 0 14 14 11 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCM00695.1 - 0.00024 21.1 0.8 0.84 9.8 0.0 5.1 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat RPN7 PF10602.9 CCM00695.1 - 0.00029 20.6 0.1 3.6 7.3 0.0 4.5 4 0 0 4 4 4 2 26S proteasome subunit RPN7 FAT PF02259.23 CCM00695.1 - 0.021 14.0 5.6 16 4.6 0.7 4.5 4 0 0 4 4 4 0 FAT domain PknG_TPR PF16918.5 CCM00695.1 - 0.025 13.3 8.5 0.018 13.8 0.4 4.5 5 0 0 5 5 5 0 Protein kinase G tetratricopeptide repeat TPR_22 PF18833.1 CCM00695.1 - 0.086 13.0 0.0 0.33 11.1 0.0 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat DUF3856 PF12968.7 CCM00695.1 - 0.1 12.7 1.4 13 5.8 0.0 3.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF3856) Glyco_hyd_65N_2 PF14498.6 CCM00695.1 - 0.28 11.0 2.3 7.4 6.3 0.1 2.6 3 0 0 3 3 2 0 Glycosyl hydrolase family 65, N-terminal domain TPR_20 PF14561.6 CCM00695.1 - 0.38 11.1 16.4 1.2 9.5 0.2 6.6 8 2 1 9 9 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCM00695.1 - 1.3 9.0 26.6 1.9 8.5 2.0 9.1 11 0 0 11 11 9 0 Tetratricopeptide repeat LETM1 PF07766.13 CCM00696.1 - 0.00018 21.0 0.1 0.00022 20.6 0.1 1.1 1 0 0 1 1 1 1 LETM1-like protein DUF3275 PF11679.8 CCM00696.1 - 0.2 11.6 3.0 0.15 12.0 1.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3275) LETM1 PF07766.13 CCM00697.1 - 2.1e-15 56.8 0.2 1.3e-13 50.9 0.1 2.0 2 0 0 2 2 2 2 LETM1-like protein Glyco_hydro_115 PF15979.5 CCM00698.1 - 6.1e-113 377.7 1.2 2.7e-83 280.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolase family 115 GH115_C PF17829.1 CCM00698.1 - 1.3e-48 165.1 0.0 2.4e-48 164.2 0.0 1.4 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain DHHC PF01529.20 CCM00699.1 - 1.6e-19 70.4 9.4 1.6e-19 70.4 9.4 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase Orf78 PF06024.12 CCM00699.1 - 0.0091 16.3 0.0 4.9 7.5 0.0 3.0 3 0 0 3 3 3 1 Orf78 (ac78) BioY PF02632.14 CCM00699.1 - 0.011 15.8 2.2 0.017 15.2 2.2 1.2 1 0 0 1 1 1 0 BioY family CrgA PF06781.12 CCM00699.1 - 0.012 15.7 0.0 0.029 14.4 0.0 1.7 1 0 0 1 1 1 0 Cell division protein CrgA OAD_gamma PF04277.13 CCM00699.1 - 0.056 14.0 0.1 0.16 12.6 0.1 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Aminotran_3 PF00202.21 CCM00700.1 - 8.6e-119 396.8 0.0 1.1e-118 396.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DHHC PF01529.20 CCM00700.1 - 0.0017 18.4 0.0 0.0031 17.6 0.0 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase Beta_elim_lyase PF01212.21 CCM00700.1 - 0.0021 17.4 0.0 0.0083 15.4 0.0 2.0 2 1 0 2 2 2 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CCM00700.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Myco_arth_vir_N PF09610.10 CCM00700.1 - 0.23 11.6 0.7 0.42 10.8 0.7 1.4 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Fes1 PF08609.10 CCM00701.1 - 9.7e-24 84.1 0.4 3.9e-23 82.2 0.4 2.1 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 SIL1 PF16782.5 CCM00701.1 - 0.00019 20.8 0.0 0.00029 20.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 HEAT PF02985.22 CCM00701.1 - 0.026 14.8 2.4 9 6.9 0.1 3.9 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 CCM00701.1 - 0.06 13.9 2.8 3.6 8.2 0.2 3.8 3 1 0 3 3 3 0 HEAT-like repeat HEAT_2 PF13646.6 CCM00701.1 - 0.24 11.8 2.2 0.59 10.6 0.3 2.6 3 1 0 3 3 3 0 HEAT repeats Membr_traf_MHD PF10540.9 CCM00705.1 - 1e-22 80.9 0.1 2.7e-11 43.8 0.0 3.0 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 CCM00705.1 - 3.5e-13 49.7 0.0 1.8e-12 47.5 0.0 2.2 3 0 0 3 3 3 1 C2 domain BP28CT PF08146.12 CCM00706.1 - 3.9e-22 78.8 0.1 1.9e-21 76.5 0.1 2.3 1 0 0 1 1 1 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 CCM00706.1 - 3.1e-11 43.6 4.4 8.9e-11 42.2 0.4 4.2 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 CCM00706.1 - 0.00037 20.5 1.1 6 7.4 0.1 5.6 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 CCM00706.1 - 2 8.8 12.1 42 4.6 0.1 6.5 6 1 0 6 6 6 0 HEAT repeats HSP70 PF00012.20 CCM00707.1 - 2.2e-74 250.7 7.3 2.2e-74 250.7 7.3 2.1 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CCM00707.1 - 0.0001 21.3 1.4 0.0011 17.8 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CCM00707.1 - 0.00054 19.7 2.8 0.001 18.8 1.5 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4653 PF15546.6 CCM00707.1 - 0.025 14.2 0.4 0.063 12.9 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) YkyA PF10368.9 CCM00707.1 - 0.72 9.5 4.1 1.1 8.9 2.4 2.1 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein Pkinase PF00069.25 CCM00708.1 - 3.3e-37 128.3 0.0 5e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00708.1 - 2.5e-29 102.4 0.0 3.7e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM00708.1 - 2.8e-08 33.4 0.0 4.8e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like WD40 PF00400.32 CCM00708.1 - 4.2e-08 33.7 6.6 0.0074 17.1 0.0 5.3 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00708.1 - 3.8e-07 30.3 1.0 0.036 14.4 0.0 3.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PBD PF00786.28 CCM00708.1 - 8.9e-05 22.8 0.0 0.00022 21.5 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain APH PF01636.23 CCM00708.1 - 0.14 12.0 0.1 0.32 10.9 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family SKG6 PF08693.10 CCM00709.1 - 0.025 14.0 0.9 0.025 14.0 0.9 2.1 2 0 0 2 2 2 0 Transmembrane alpha-helix domain EphA2_TM PF14575.6 CCM00709.1 - 0.043 14.7 0.0 0.086 13.7 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 CCM00709.1 - 0.13 11.1 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Amnionless Gram_pos_anchor PF00746.21 CCM00709.1 - 0.13 12.2 1.0 0.65 10.0 1.0 2.2 1 0 0 1 1 1 0 LPXTG cell wall anchor motif NUDIX PF00293.28 CCM00710.1 - 8.6e-10 38.8 0.0 1.4e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DUF4620 PF15399.6 CCM00710.1 - 0.013 15.9 0.3 0.027 14.8 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4620) DUF1289 PF06945.13 CCM00711.1 - 0.039 13.8 0.6 0.06 13.2 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) F-box-like PF12937.7 CCM00712.1 - 0.0089 15.9 0.1 0.066 13.1 0.0 2.4 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 CCM00713.1 - 9e-12 45.1 2.1 0.00085 19.6 0.1 4.5 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCM00713.1 - 1.1e-06 29.2 22.6 0.0029 18.4 1.0 6.6 7 0 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 CCM00713.1 - 0.0043 17.0 0.1 0.26 11.2 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DUF1513 PF07433.11 CCM00713.1 - 0.11 11.5 0.6 1.1 8.3 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1513) Glyco_hydro_115 PF15979.5 CCM00715.1 - 2e-133 445.0 0.9 3.1e-133 444.4 0.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 CCM00715.1 - 7.5e-52 175.6 0.0 1.5e-51 174.7 0.0 1.5 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Aldo_ket_red PF00248.21 CCM00716.1 - 2.1e-30 106.0 0.0 3.2e-27 95.5 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family DUF4101 PF13355.6 CCM00716.1 - 0.073 13.5 0.2 12 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4101) HA2 PF04408.23 CCM00717.1 - 1.9e-23 82.8 0.0 4.5e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCM00717.1 - 1e-20 73.9 0.0 3.9e-20 72.0 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCM00717.1 - 7.3e-10 39.2 0.0 4e-09 36.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCM00717.1 - 7.5e-08 32.3 0.1 1.5e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SRP54 PF00448.22 CCM00717.1 - 6.4e-05 22.7 0.2 0.00018 21.2 0.2 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 CCM00717.1 - 0.00096 19.5 0.1 0.0022 18.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCM00717.1 - 0.0065 16.7 0.3 0.024 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CCM00717.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 CCM00717.1 - 0.042 13.6 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCM00717.1 - 0.051 13.1 0.1 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 CCM00717.1 - 0.14 11.6 0.0 0.49 9.8 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AMP-binding PF00501.28 CCM00718.1 - 3.7e-52 177.4 0.3 1.9e-25 89.4 0.5 2.2 2 0 0 2 2 2 2 AMP-binding enzyme ADH_N PF08240.12 CCM00718.1 - 1.2e-31 108.8 3.6 2.9e-31 107.6 3.6 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM00718.1 - 5.5e-16 58.7 0.0 1.9e-15 57.0 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AMP-binding_C PF13193.6 CCM00718.1 - 5.9e-13 49.6 0.2 2e-12 47.9 0.2 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glu_dehyd_C PF16912.5 CCM00718.1 - 1.3e-10 41.1 0.0 3.2e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCM00718.1 - 0.00016 22.7 0.0 0.00044 21.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 CCM00718.1 - 0.0012 18.2 0.7 0.0018 17.6 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain Staph_opine_DH PF10100.9 CCM00718.1 - 0.11 11.1 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Staphylopine dehydrogenase AAA_13 PF13166.6 CCM00719.1 - 1 7.9 5.6 1.8 7.1 5.6 1.4 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 CCM00719.1 - 1.1 6.6 18.8 1.9 5.9 18.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Nsp1_C PF05064.13 CCM00719.1 - 4.5 7.1 10.0 5.9 6.7 4.2 2.9 3 0 0 3 3 3 0 Nsp1-like C-terminal region RRF PF01765.19 CCM00719.1 - 7.3 6.5 11.5 0.77 9.7 0.5 3.0 2 1 1 3 3 3 0 Ribosome recycling factor Syntaxin-6_N PF09177.11 CCM00719.1 - 9.7 6.8 13.0 35 5.0 7.1 3.2 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Arm PF00514.23 CCM00720.1 - 0.01 15.9 0.2 3.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCM00720.1 - 0.026 15.0 0.0 1.2 9.8 0.0 2.5 2 0 0 2 2 2 0 HEAT-like repeat BCNT PF07572.12 CCM00722.1 - 1.4e-18 66.8 0.1 2.4e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 Bucentaur or craniofacial development ProRS-C_1 PF09180.11 CCM00723.1 - 2.5e-27 94.9 2.4 5.4e-27 93.8 2.4 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 CCM00723.1 - 5.2e-17 62.4 0.0 8.9e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCM00723.1 - 1.1e-14 54.3 0.0 2.8e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_edit PF04073.15 CCM00723.1 - 1.3e-09 38.2 0.0 2.5e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_1 PF00133.22 CCM00724.1 - 2.7e-128 428.9 0.0 3.2e-128 428.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCM00724.1 - 6.7e-11 42.4 0.2 1.4e-10 41.4 0.2 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCM00724.1 - 1.4e-06 27.4 0.0 0.54 9.0 0.0 3.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) Cyclin_N PF00134.23 CCM00725.1 - 3.6e-44 149.6 1.0 8.5e-44 148.4 0.4 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCM00725.1 - 2e-27 95.7 0.1 4.4e-27 94.5 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_L19 PF01245.20 CCM00725.1 - 0.084 12.8 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L19 GST_N_3 PF13417.6 CCM00726.1 - 3.7e-11 43.3 0.0 6.2e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM00726.1 - 8.5e-08 32.4 0.1 1.4e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM00726.1 - 0.00039 20.4 0.2 0.00089 19.2 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain UCH PF00443.29 CCM00727.1 - 1.8e-38 132.5 0.0 2.5e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM00727.1 - 5.7e-10 39.3 0.0 0.00011 21.9 0.0 3.2 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase Aminotran_1_2 PF00155.21 CCM00728.1 - 1.1e-53 182.7 0.0 1.3e-53 182.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCM00728.1 - 0.014 14.2 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase WD40 PF00400.32 CCM00729.1 - 7.3e-52 172.2 22.2 7.5e-11 42.4 0.5 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00729.1 - 8.9e-19 67.6 2.4 0.0024 18.1 0.0 5.6 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM00729.1 - 9.6e-07 28.1 0.4 0.1 11.5 0.0 4.8 2 2 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CCM00729.1 - 0.0012 18.7 1.0 2.1 8.4 0.1 3.1 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat IKI3 PF04762.12 CCM00729.1 - 2.7 5.9 3.6 13 3.6 0.1 2.7 2 1 1 4 4 4 0 IKI3 family Glyco_hydro_1 PF00232.18 CCM00730.1 - 1.4e-156 521.4 0.4 1.6e-156 521.3 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Mersacidin PF16934.5 CCM00730.1 - 0.08 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) COesterase PF00135.28 CCM00731.1 - 7.7e-07 28.3 0.0 3.1e-06 26.4 0.0 1.9 1 1 0 1 1 1 1 Carboxylesterase family ArgJ PF01960.18 CCM00733.1 - 3.3e-148 493.4 0.4 3.7e-148 493.3 0.4 1.0 1 0 0 1 1 1 1 ArgJ family Ribosomal_L35Ae PF01247.18 CCM00734.1 - 1.9e-44 149.8 0.6 2.3e-44 149.5 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CCM00734.1 - 0.00087 19.5 0.1 1 9.7 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Sec6 PF06046.13 CCM00735.1 - 2.2e-154 515.0 4.0 2.2e-154 515.0 4.0 1.8 2 0 0 2 2 2 1 Exocyst complex component Sec6 SKA2 PF16740.5 CCM00735.1 - 0.00081 19.2 4.5 0.033 14.0 0.9 4.0 3 1 0 3 3 3 1 Spindle and kinetochore-associated protein 2 HECT PF00632.25 CCM00735.1 - 0.0042 16.6 0.0 0.009 15.5 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Vps53_N PF04100.12 CCM00735.1 - 0.015 14.3 6.6 0.15 11.0 3.5 2.8 1 1 1 2 2 2 0 Vps53-like, N-terminal HEPN_RiboL-PSP PF18735.1 CCM00735.1 - 0.18 11.7 4.7 0.68 9.8 0.3 3.3 2 1 1 3 3 3 0 RiboL-PSP-HEPN Fes1 PF08609.10 CCM00735.1 - 1.3 9.9 5.4 3 8.8 0.1 3.9 4 0 0 4 4 4 0 Nucleotide exchange factor Fes1 DUF5638 PF18688.1 CCM00735.1 - 4 7.8 11.7 13 6.2 0.1 4.9 5 1 1 6 6 6 0 Family of unknown function (DUF5638) CN_hydrolase PF00795.22 CCM00736.1 - 1.3e-38 132.8 0.0 2.5e-38 131.9 0.0 1.4 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 CCM00736.1 - 1.9e-17 63.2 0.0 6.4e-17 61.5 0.0 1.8 1 1 0 1 1 1 1 NAD synthase RRM_1 PF00076.22 CCM00737.1 - 9.1e-21 73.5 0.0 2.6e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM00737.1 - 0.00031 20.8 0.0 0.00045 20.3 0.0 1.3 1 1 0 1 1 1 1 RNA recognition motif GRP PF07172.11 CCM00737.1 - 0.00065 20.3 33.2 0.00081 20.0 33.2 1.3 1 0 0 1 1 1 1 Glycine rich protein family ACC_central PF08326.12 CCM00738.1 - 5.3e-251 834.9 0.0 6.6e-251 834.6 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 CCM00738.1 - 3e-172 573.7 0.0 3.9e-172 573.3 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 CCM00738.1 - 7.6e-51 172.6 0.1 1.8e-50 171.4 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CCM00738.1 - 1.2e-28 99.8 0.1 2.6e-28 98.8 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CCM00738.1 - 3.3e-20 72.2 0.0 4.6e-19 68.5 0.0 2.9 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CCM00738.1 - 4.7e-16 58.4 0.0 1e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 CCM00738.1 - 0.0032 17.6 0.0 0.013 15.6 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 CCM00738.1 - 0.0051 16.6 0.0 0.017 15.0 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 CCM00738.1 - 0.01 15.4 0.0 0.025 14.1 0.0 1.7 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Fer2_4 PF13510.6 CCM00738.1 - 0.013 15.5 0.1 0.1 12.6 0.1 2.4 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain ATP-grasp PF02222.22 CCM00738.1 - 0.037 13.6 0.1 0.083 12.5 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_Ter PF15632.6 CCM00738.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Zds_C PF08632.10 CCM00739.1 - 1.1e-28 98.7 0.8 2e-28 97.9 0.8 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term PH_10 PF15411.6 CCM00740.1 - 8.6e-24 84.1 0.0 1.5e-23 83.4 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain zf-RING_2 PF13639.6 CCM00740.1 - 0.00017 21.9 1.0 0.00034 20.9 1.0 1.6 1 0 0 1 1 1 1 Ring finger domain VWA PF00092.28 CCM00740.1 - 0.00036 20.8 0.0 0.00084 19.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-RING_UBOX PF13445.6 CCM00740.1 - 0.00047 20.1 1.8 0.0011 19.0 1.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger VWA_3 PF13768.6 CCM00740.1 - 0.0016 18.4 0.0 0.0069 16.3 0.0 2.1 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-RING_5 PF14634.6 CCM00740.1 - 0.005 16.8 0.6 0.0089 16.0 0.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 CCM00740.1 - 0.13 12.0 2.7 0.35 10.7 2.7 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCM00740.1 - 1.1 9.1 2.9 4.1 7.3 2.9 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Metallophos PF00149.28 CCM00741.1 - 3.3e-12 47.3 0.2 4e-12 47.1 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCM00741.1 - 3.3e-07 30.6 0.0 1.7e-05 25.0 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain zf-ZPR1 PF03367.13 CCM00744.1 - 4e-110 364.8 0.3 1.4e-55 187.6 0.0 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain DUF2688 PF10892.8 CCM00744.1 - 0.0023 17.4 0.6 0.82 9.2 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF2688) Zn-ribbon_8 PF09723.10 CCM00744.1 - 0.0034 17.5 2.5 7.6 6.8 0.1 3.8 3 1 0 3 3 3 2 Zinc ribbon domain DZR PF12773.7 CCM00744.1 - 0.022 14.8 3.7 0.51 10.4 0.1 2.9 2 1 0 2 2 2 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 CCM00744.1 - 0.23 11.4 3.0 29 4.7 0.0 3.5 3 0 0 3 3 3 0 Putative transposase DNA-binding domain E1-E2_ATPase PF00122.20 CCM00745.1 - 9.2e-48 162.2 4.8 1.9e-47 161.1 4.8 1.6 1 0 0 1 1 1 1 E1-E2 ATPase HMA PF00403.26 CCM00745.1 - 6.4e-29 100.2 0.0 2.5e-13 50.3 0.1 2.7 2 0 0 2 2 2 2 Heavy-metal-associated domain Hydrolase PF00702.26 CCM00745.1 - 4.9e-27 95.6 1.4 8.2e-27 94.9 0.4 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CCM00745.1 - 0.0078 16.0 0.3 0.1 12.3 0.3 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Dynactin_p22 PF07426.11 CCM00746.1 - 2.4e-19 69.8 0.0 3.1e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Dynactin subunit p22 T2SSF PF00482.23 CCM00746.1 - 0.076 13.0 0.5 0.15 12.0 0.5 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF4200 PF13863.6 CCM00746.1 - 0.12 12.7 0.5 26 5.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Ank_2 PF12796.7 CCM00747.1 - 0.00022 21.8 0.0 0.0005 20.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM00747.1 - 0.0018 18.5 0.0 0.0042 17.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM00747.1 - 0.017 15.6 0.0 0.058 14.0 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.30 CCM00747.1 - 0.025 15.0 0.0 0.068 13.7 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat Paramyxo_C PF01692.18 CCM00748.1 - 0.79 9.1 3.8 1.2 8.5 3.8 1.1 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C OPT PF03169.15 CCM00750.1 - 4e-180 600.5 60.6 4.6e-180 600.3 60.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein SHNi-TPR PF10516.9 CCM00751.1 - 8.5e-16 57.1 0.3 1.5e-13 49.9 0.0 3.1 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.6 CCM00751.1 - 8e-14 51.7 7.4 8.1e-07 29.2 0.2 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCM00751.1 - 3.7e-08 32.9 1.3 0.15 12.3 0.3 4.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM00751.1 - 1.4e-07 31.1 0.2 0.14 12.0 0.3 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCM00751.1 - 2.1e-05 24.1 3.9 0.23 11.2 0.0 4.5 4 1 0 4 4 4 2 TPR repeat TPR_8 PF13181.6 CCM00751.1 - 0.0013 18.8 2.7 2.1 8.7 0.0 4.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCM00751.1 - 0.0047 16.8 4.2 1.7 8.9 0.1 4.1 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCM00751.1 - 0.014 15.2 2.7 7 6.7 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCM00751.1 - 0.017 15.8 12.9 1.5 9.6 4.3 4.7 3 2 1 4 4 3 0 Tetratricopeptide repeat Methyltransf_31 PF13847.6 CCM00751.1 - 0.063 13.1 1.8 2 8.2 0.7 2.5 2 0 0 2 2 2 0 Methyltransferase domain CreD PF06123.12 CCM00751.1 - 0.17 10.6 0.0 4.2 6.0 0.0 2.1 2 0 0 2 2 2 0 Inner membrane protein CreD TPR_14 PF13428.6 CCM00751.1 - 0.26 12.2 11.5 5 8.2 0.5 5.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCM00751.1 - 1.2 9.7 14.1 0.68 10.5 0.1 4.8 3 1 1 4 4 4 0 Tetratricopeptide repeat Aldedh PF00171.22 CCM00752.1 - 1e-13 50.6 5.6 4.9e-10 38.5 4.5 2.6 2 1 0 2 2 2 2 Aldehyde dehydrogenase family ANTH PF07651.16 CCM00755.1 - 1.3e-50 172.0 0.2 2.7e-50 170.9 0.0 1.6 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.20 CCM00755.1 - 0.00012 22.1 0.0 0.00026 21.0 0.0 1.5 1 0 0 1 1 1 1 ENTH domain Glyco_hydro_47 PF01532.20 CCM00756.1 - 6.7e-107 358.2 0.0 8.6e-107 357.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 FGGY_N PF00370.21 CCM00757.1 - 1.1e-63 215.0 0.2 4.5e-62 209.8 0.2 2.1 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CCM00757.1 - 1.5e-61 207.6 1.0 4.8e-61 205.9 0.9 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Pkinase PF00069.25 CCM00758.1 - 5.7e-32 111.1 0.0 3.3e-31 108.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00758.1 - 1.9e-11 43.7 0.0 3.6e-11 42.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM00758.1 - 1.4e-05 25.1 0.5 0.0019 18.1 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCM00758.1 - 0.044 13.1 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DEAD PF00270.29 CCM00759.1 - 2.9e-38 131.4 0.6 4.2e-38 130.8 0.6 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM00759.1 - 3.1e-29 101.6 0.0 1e-28 99.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM00759.1 - 5.7e-07 29.7 0.0 1.4e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDC45 PF02724.14 CCM00759.1 - 0.00098 17.5 2.5 0.0013 17.2 2.5 1.2 1 0 0 1 1 1 1 CDC45-like protein Apt1 PF10351.9 CCM00759.1 - 0.053 12.4 6.0 0.074 11.9 6.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCDC106 PF15794.5 CCM00759.1 - 0.15 11.8 7.8 0.31 10.7 7.8 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Presenilin PF01080.17 CCM00759.1 - 0.24 10.1 4.6 0.4 9.4 4.6 1.2 1 0 0 1 1 1 0 Presenilin F-box-like PF12937.7 CCM00761.1 - 4.3e-13 48.9 4.2 7.1e-12 45.0 0.0 3.6 4 0 0 4 4 4 1 F-box-like F-box PF00646.33 CCM00761.1 - 0.00059 19.7 0.1 0.16 11.9 0.0 3.4 2 0 0 2 2 2 2 F-box domain Catalase PF00199.19 CCM00762.1 - 3e-173 576.3 0.1 4.3e-173 575.8 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CCM00762.1 - 2.5e-18 66.0 0.1 7.6e-18 64.5 0.1 1.9 2 0 0 2 2 2 1 Catalase-related immune-responsive Catalase_C PF18011.1 CCM00762.1 - 8e-13 48.3 0.1 1.5e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 CCM00762.1 - 2.3e-12 47.0 0.0 3.9e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S41 PF03572.18 CCM00765.1 - 0.00018 21.1 0.0 0.00036 20.2 0.0 1.6 1 1 0 1 1 1 1 Peptidase family S41 Enterotoxin_a PF01375.17 CCM00765.1 - 0.014 15.0 0.1 0.031 13.9 0.1 1.5 1 0 0 1 1 1 0 Heat-labile enterotoxin alpha chain Aldo_ket_red PF00248.21 CCM00766.1 - 1.3e-45 155.9 0.0 1.2e-36 126.4 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family NAD_binding_4 PF07993.12 CCM00767.1 - 4.7e-31 107.9 0.0 7.2e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CCM00767.1 - 3.4e-29 101.7 0.0 5.4e-29 101.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CCM00767.1 - 6e-11 42.3 0.0 1.1e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM00767.1 - 0.00091 19.5 0.0 0.0021 18.4 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site GDP_Man_Dehyd PF16363.5 CCM00767.1 - 0.0076 15.7 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase BTB PF00651.31 CCM00768.1 - 0.0009 19.5 0.0 0.0029 17.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Peroxin-3 PF04882.12 CCM00769.1 - 0.096 11.7 1.5 0.18 10.8 1.5 1.4 1 1 0 1 1 1 0 Peroxin-3 Sod_Fe_C PF02777.18 CCM00771.1 - 4.6e-35 119.9 0.3 7.6e-35 119.2 0.0 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CCM00771.1 - 4.3e-32 110.4 2.4 1.1e-31 109.1 1.3 2.0 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain NAD_binding_4 PF07993.12 CCM00772.1 - 2.1e-34 118.9 0.0 3e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCM00772.1 - 2.7e-08 33.6 0.0 3.8e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM00772.1 - 0.005 15.9 0.0 0.0093 15.0 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TOM6p PF15184.6 CCM00772.1 - 0.0099 15.6 0.0 0.025 14.3 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial import receptor subunit TOM6 homolog KR PF08659.10 CCM00772.1 - 0.087 12.7 0.1 0.23 11.3 0.1 1.8 1 1 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 CCM00772.1 - 0.09 11.9 0.0 0.74 8.9 0.0 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CCM00772.1 - 0.13 11.6 0.0 0.45 9.8 0.0 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase ABC_membrane_2 PF06472.15 CCM00773.1 - 1.7e-76 257.2 0.4 2.9e-76 256.4 0.1 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CCM00773.1 - 3.9e-16 59.8 0.0 1.4e-15 58.0 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 CCM00773.1 - 0.029 14.8 0.0 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 CCM00773.1 - 0.043 13.7 0.1 0.092 12.7 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 CCM00773.1 - 0.066 12.8 0.2 0.16 11.5 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CCM00773.1 - 0.076 12.7 1.1 0.14 11.8 1.1 1.5 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CCM00773.1 - 0.18 11.5 0.3 0.49 10.1 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Kinetochor_Ybp2 PF08568.10 CCM00775.1 - 1.1e-16 60.5 0.1 8.1e-13 47.7 0.0 2.1 2 0 0 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin SNF2_N PF00176.23 CCM00776.1 - 6.2e-56 189.6 1.5 1.9e-55 188.0 1.5 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM00776.1 - 1.1e-11 45.0 0.0 2.9e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 CCM00776.1 - 5.8e-10 39.0 3.7 1.3e-09 37.9 3.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger ResIII PF04851.15 CCM00776.1 - 3.5e-08 33.6 0.0 1.1e-07 32.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 CCM00776.1 - 7.9e-08 32.0 5.5 7.9e-08 32.0 5.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCM00776.1 - 8.5e-08 32.4 7.7 2e-07 31.2 7.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CCM00776.1 - 3e-06 27.0 9.9 1e-05 25.3 9.9 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM00776.1 - 7.3e-06 25.8 8.1 1.5e-05 24.7 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM00776.1 - 1.1e-05 25.2 7.7 2.2e-05 24.3 7.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCM00776.1 - 5.5e-05 23.2 7.5 0.00015 21.8 7.5 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 CCM00776.1 - 0.0056 16.5 9.2 0.051 13.4 9.2 2.4 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Plasmid_RAQPRD PF09686.10 CCM00776.1 - 0.019 15.2 0.9 0.059 13.6 0.9 1.9 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) zf-Nse PF11789.8 CCM00776.1 - 0.14 12.0 2.6 0.35 10.7 2.6 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF2616 PF11077.8 CCM00776.1 - 0.22 11.2 3.7 0.71 9.6 3.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) DTHCT PF08070.11 CCM00776.1 - 0.37 11.5 32.6 0.31 11.8 1.3 5.1 3 2 2 5 5 5 0 DTHCT (NUC029) region zf-RING_6 PF14835.6 CCM00776.1 - 0.72 9.8 3.2 2.6 8.0 3.2 1.9 1 0 0 1 1 1 0 zf-RING of BARD1-type protein FYVE PF01363.21 CCM00776.1 - 1 9.5 7.8 2.4 8.3 7.8 1.6 1 0 0 1 1 1 0 FYVE zinc finger DUF3123 PF11321.8 CCM00776.1 - 1.8 9.2 0.0 1.8 9.2 0.0 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3123) zf-RING_11 PF17123.5 CCM00776.1 - 2.3 8.0 9.5 6.2 6.7 9.5 1.8 1 0 0 1 1 1 0 RING-like zinc finger Dicty_CAR PF05462.11 CCM00777.1 - 9.3e-06 25.0 5.2 1.3e-05 24.5 5.2 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 CCM00777.1 - 0.03 13.6 11.6 0.066 12.5 6.5 2.0 1 1 1 2 2 2 0 7 transmembrane receptor (Secretin family) FMN_dh PF01070.18 CCM00779.1 - 3.5e-108 361.8 0.0 4.7e-108 361.3 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCM00779.1 - 1.2e-16 60.5 0.0 2.9e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NMO PF03060.15 CCM00779.1 - 0.00044 19.8 0.0 0.0061 16.0 0.0 2.2 1 1 1 2 2 2 1 Nitronate monooxygenase Glu_synthase PF01645.17 CCM00779.1 - 0.0014 17.8 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCM00779.1 - 0.0059 15.7 0.4 0.031 13.3 0.1 2.2 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CCM00779.1 - 0.12 11.8 0.0 14 5.1 0.0 2.5 3 0 0 3 3 3 0 Histidine biosynthesis protein RdRP PF05183.12 CCM00780.1 - 1.5e-122 410.3 0.0 2e-122 409.8 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase G-alpha PF00503.20 CCM00780.1 - 1.3e-95 320.6 0.0 1.5e-59 201.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 CCM00780.1 - 0.022 14.2 0.3 1.5 8.3 0.0 3.1 2 1 1 3 3 3 0 ADP-ribosylation factor family TniB PF05621.11 CCM00780.1 - 0.024 14.0 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 CCM00780.1 - 0.07 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain CPCFC PF17223.3 CCM00780.1 - 0.14 11.9 2.1 12 5.8 0.0 2.5 2 0 0 2 2 2 0 Cuticle protein CPCFC AAA_29 PF13555.6 CCM00780.1 - 0.15 11.8 0.0 0.4 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain adh_short PF00106.25 CCM00781.1 - 1.5e-28 99.6 0.1 2e-28 99.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00781.1 - 9.6e-22 77.7 0.0 1.2e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCM00781.1 - 4.3e-07 30.0 0.5 9.1e-07 28.9 0.5 1.5 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 CCM00781.1 - 1.1e-05 25.5 0.5 1.5e-05 25.0 0.4 1.5 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 CCM00781.1 - 0.0001 22.0 0.7 0.00017 21.2 0.7 1.3 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 CCM00781.1 - 0.0013 18.9 0.2 0.0025 18.1 0.2 1.4 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 CCM00781.1 - 0.0014 18.1 0.0 0.0034 16.9 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCM00781.1 - 0.023 13.8 0.1 0.042 12.9 0.1 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CCM00781.1 - 0.046 13.1 0.0 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCM00781.1 - 0.079 12.0 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Mob1_phocein PF03637.17 CCM00782.1 - 1.8e-24 86.7 0.0 3e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Mob1/phocein family ABC2_membrane PF01061.24 CCM00783.1 - 3.7e-73 245.4 50.6 2.3e-41 141.5 18.6 2.9 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.12 CCM00783.1 - 8e-38 128.2 14.3 1.3e-31 108.3 0.2 2.9 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.27 CCM00783.1 - 2.4e-37 128.5 0.0 1.8e-17 64.2 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.6 CCM00783.1 - 8e-16 58.4 0.0 1.9e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 CCM00783.1 - 3.2e-07 30.4 0.1 5.5e-05 23.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CCM00783.1 - 1.5e-06 28.7 0.0 0.015 15.7 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CCM00783.1 - 6e-05 23.3 0.0 0.3 11.4 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCM00783.1 - 0.00029 20.5 0.1 0.026 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCM00783.1 - 0.00051 20.6 0.0 1.1 9.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CCM00783.1 - 0.00057 20.0 0.0 0.81 9.8 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 CCM00783.1 - 0.0012 19.0 0.1 0.52 10.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCM00783.1 - 0.0017 18.0 0.4 0.23 11.2 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain cobW PF02492.19 CCM00783.1 - 0.0033 17.1 0.2 2.3 7.8 0.5 2.9 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 CCM00783.1 - 0.0084 16.4 0.4 3.8 7.7 0.5 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CCM00783.1 - 0.014 14.7 0.1 1.6 8.0 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin SMC_N PF02463.19 CCM00783.1 - 0.047 13.1 0.0 1 8.7 0.0 2.7 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 CCM00783.1 - 0.052 13.5 0.3 2.1 8.3 0.3 2.5 2 0 0 2 2 2 0 NACHT domain AAA_21 PF13304.6 CCM00783.1 - 0.087 12.6 0.0 18 5.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CCM00783.1 - 0.094 12.4 0.4 1.8 8.2 0.5 2.3 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CCM00783.1 - 0.14 12.4 0.3 7.4 6.8 0.1 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 CCM00783.1 - 0.14 12.7 0.1 0.29 11.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 CCM00783.1 - 0.23 10.7 0.0 10 5.3 0.0 2.3 2 0 0 2 2 2 0 Septin ABC2_membrane_3 PF12698.7 CCM00783.1 - 0.39 9.8 46.0 0.028 13.5 19.4 2.9 2 1 1 3 3 3 0 ABC-2 family transporter protein Hce2 PF14856.6 CCM00785.1 - 0.043 14.1 0.2 0.26 11.6 0.1 2.0 1 1 1 2 2 2 0 Pathogen effector; putative necrosis-inducing factor Trp_oprn_chp PF09534.10 CCM00786.1 - 0.047 13.5 2.9 0.076 12.8 2.9 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Calcipressin PF04847.12 CCM00786.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Calcipressin Transglut_core PF01841.19 CCM00790.1 - 8.4e-12 45.5 0.0 1.9e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 CCM00790.1 - 0.033 13.7 0.0 0.85 9.1 0.0 2.2 1 1 0 1 1 1 0 Transglutaminase-like domain E1_FCCH PF16190.5 CCM00792.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 FCCH domain FliC_SP PF12613.8 CCM00793.1 - 3.4 8.2 12.1 17 6.0 12.2 2.1 1 1 1 2 2 2 0 Flagellin structural protein Hce2 PF14856.6 CCM00794.1 - 0.0014 18.9 0.5 0.0093 16.2 0.2 2.0 1 1 1 2 2 2 1 Pathogen effector; putative necrosis-inducing factor Pkinase_fungal PF17667.1 CCM00795.1 - 8.7e-27 93.9 1.1 4.1e-26 91.7 0.0 2.4 2 1 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 CCM00795.1 - 2.8e-05 23.6 0.0 4.3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCM00795.1 - 0.0038 17.2 0.7 0.0093 15.9 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Nop14 PF04147.12 CCM00795.1 - 0.3 9.2 16.5 0.44 8.7 16.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2076 PF09849.9 CCM00795.1 - 2.5 8.1 12.2 4.8 7.1 12.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CH PF00307.31 CCM00796.1 - 1.9e-78 259.7 0.0 1.5e-19 70.2 0.0 4.6 4 1 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 CCM00796.1 - 2.3e-06 27.4 0.0 9.7 6.1 0.0 4.5 4 0 0 4 4 4 4 CAMSAP CH domain CH_2 PF06294.11 CCM00796.1 - 0.032 14.4 0.0 0.92 9.7 0.0 2.7 2 0 0 2 2 2 0 CH-like domain in sperm protein Amidase PF01425.21 CCM00797.1 - 1.8e-92 310.6 0.0 2.5e-92 310.2 0.0 1.2 1 0 0 1 1 1 1 Amidase Amidase PF01425.21 CCM00798.1 - 5.7e-92 309.0 0.0 6.9e-92 308.7 0.0 1.1 1 0 0 1 1 1 1 Amidase Baculo_PEP_C PF04513.12 CCM00799.1 - 0.00027 21.0 3.2 0.19 11.8 0.2 3.1 3 1 0 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus IMD PF08397.11 CCM00799.1 - 0.06 12.7 0.1 23 4.3 0.0 3.1 3 0 0 3 3 3 0 IRSp53/MIM homology domain Sipho_Gp157 PF05565.11 CCM00799.1 - 0.09 12.8 1.1 0.39 10.7 0.1 2.2 2 0 0 2 2 2 0 Siphovirus Gp157 WXG100 PF06013.12 CCM00799.1 - 0.5 10.6 7.0 7.3 6.9 0.1 3.9 3 2 1 4 4 4 0 Proteins of 100 residues with WXG DUF5082 PF16888.5 CCM00799.1 - 1.1 9.6 3.9 13 6.1 0.3 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF5082) Prefoldin PF02996.17 CCM00799.1 - 3.6 7.5 8.9 0.65 9.9 1.0 2.9 3 0 0 3 3 3 0 Prefoldin subunit DivIC PF04977.15 CCM00799.1 - 4.9 7.0 6.2 8.1 6.3 0.4 2.9 3 0 0 3 3 3 0 Septum formation initiator DUF4407 PF14362.6 CCM00800.1 - 0.024 14.0 0.2 0.04 13.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 CCM00800.1 - 0.033 14.4 5.2 3.4 7.9 0.2 3.3 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Bacillus_HBL PF05791.11 CCM00800.1 - 0.052 13.4 8.6 0.24 11.2 4.2 2.5 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) TBCC_N PF16752.5 CCM00800.1 - 0.057 13.9 2.4 0.24 11.8 0.2 2.7 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain ZapB PF06005.12 CCM00800.1 - 0.076 13.5 3.2 0.14 12.6 0.2 2.7 3 0 0 3 3 3 0 Cell division protein ZapB OmpH PF03938.14 CCM00800.1 - 0.092 13.1 4.8 0.13 12.5 1.8 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Mod_r PF07200.13 CCM00800.1 - 0.11 12.6 3.8 0.17 11.9 0.2 2.8 4 0 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DivIC PF04977.15 CCM00800.1 - 0.29 10.9 5.4 3.8 7.4 0.4 3.0 3 0 0 3 3 3 0 Septum formation initiator SEO_N PF14576.6 CCM00801.1 - 0.073 12.2 0.2 0.098 11.8 0.2 1.2 1 0 0 1 1 1 0 Sieve element occlusion N-terminus NAAA-beta PF15508.6 CCM00801.1 - 0.076 13.3 0.6 15 6.0 0.0 3.5 3 1 1 4 4 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Atypical_Card PF18461.1 CCM00801.1 - 0.12 12.6 0.2 1.3 9.3 0.1 2.2 1 1 0 2 2 2 0 Atypical caspase recruitment domain Phe_ZIP PF08916.11 CCM00801.1 - 0.33 11.7 4.3 28 5.5 4.3 2.5 1 1 0 1 1 1 0 Phenylalanine zipper Pkinase PF00069.25 CCM00802.1 - 2.8e-40 138.4 0.0 3.5e-28 98.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00802.1 - 2e-21 76.4 0.0 2.8e-21 76.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM00802.1 - 9.7e-05 21.3 0.0 0.00015 20.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCM00802.1 - 0.00028 20.9 1.2 0.00056 19.9 0.3 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 CCM00805.1 - 2.6e-51 174.5 0.0 4.6e-51 173.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00805.1 - 3.8e-27 95.2 0.0 5.7e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM00805.1 - 0.00017 21.6 0.1 0.0061 16.5 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCM00805.1 - 0.0025 17.2 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCM00805.1 - 0.023 14.0 0.0 0.39 10.0 0.0 2.4 2 1 0 2 2 2 0 Kinase-like Pkinase PF00069.25 CCM00806.1 - 4.8e-48 163.8 0.0 6.7e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00806.1 - 1.7e-29 102.9 0.0 2.2e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM00806.1 - 6.6e-05 22.4 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCM00806.1 - 0.0014 18.6 0.0 0.012 15.5 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM00806.1 - 0.014 14.2 0.0 0.026 13.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 CCM00806.1 - 0.022 13.7 0.1 0.032 13.2 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase YrbL-PhoP_reg PF10707.9 CCM00806.1 - 0.23 11.0 0.0 0.39 10.2 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.14 CCM00806.1 - 0.24 10.7 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SET PF00856.28 CCM00807.1 - 1.4e-09 38.5 0.0 2.9e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 SET domain FA_desaturase PF00487.24 CCM00809.1 - 8.3e-23 81.5 22.2 1.2e-22 81.0 22.2 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CCM00809.1 - 3.7e-08 33.7 0.1 7.3e-08 32.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) CBM_4_9 PF02018.17 CCM00810.1 - 0.0064 16.8 0.0 0.026 14.8 0.0 1.8 2 0 0 2 2 2 1 Carbohydrate binding domain AstB PF04996.12 CCM00810.1 - 0.25 10.0 0.6 0.35 9.5 0.6 1.1 1 0 0 1 1 1 0 Succinylarginine dihydrolase Alpha-L-AF_C PF06964.12 CCM00811.1 - 1.2e-37 129.7 0.3 1.7e-37 129.2 0.3 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Sugar_tr PF00083.24 CCM00812.1 - 1.1e-106 357.4 30.5 1.3e-106 357.2 30.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM00812.1 - 7.1e-22 77.8 38.7 6.5e-18 64.8 12.7 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Lactamase_B_2 PF12706.7 CCM00813.1 - 4.7e-15 55.6 0.3 6.2e-14 52.0 0.3 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Abhydrolase_1 PF00561.20 CCM00815.1 - 3.5e-10 40.0 0.0 1.5e-09 37.9 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCM00815.1 - 0.00011 22.3 0.0 0.00021 21.4 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein p450 PF00067.22 CCM00817.1 - 5.6e-50 170.4 0.0 6.6e-50 170.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 IU_nuc_hydro PF01156.19 CCM00818.1 - 0.22 11.1 0.0 0.4 10.2 0.0 1.4 1 0 0 1 1 1 0 Inosine-uridine preferring nucleoside hydrolase zf-NOSIP PF15906.5 CCM00819.1 - 8.2e-11 41.9 0.4 1.6e-10 41.0 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 CCM00819.1 - 7.7e-09 35.3 10.3 1.4e-06 27.9 0.3 3.0 2 1 1 3 3 3 2 Rtf2 RING-finger zf-C3HC4_3 PF13920.6 CCM00819.1 - 1e-08 34.9 18.2 4e-05 23.4 8.1 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM00819.1 - 3.3e-07 30.2 15.4 0.0012 18.8 0.4 2.5 2 0 0 2 2 2 2 RING-type zinc-finger zf-RING_5 PF14634.6 CCM00819.1 - 1.3e-05 25.0 21.2 3.1e-05 23.9 9.5 2.7 2 1 0 2 2 2 2 zinc-RING finger domain zf-RING_2 PF13639.6 CCM00819.1 - 2.2e-05 24.7 18.9 0.0054 17.0 10.0 2.4 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 CCM00819.1 - 5e-05 23.0 22.9 0.022 14.6 12.1 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM00819.1 - 6.4e-05 22.7 22.3 0.027 14.3 12.2 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 CCM00819.1 - 0.00046 20.3 2.5 0.00046 20.3 2.5 2.8 2 1 0 2 2 2 1 FYVE zinc finger Prok-RING_4 PF14447.6 CCM00819.1 - 0.00062 19.6 21.6 0.034 14.0 9.9 3.2 2 1 1 3 3 3 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCM00819.1 - 0.0011 19.1 14.6 0.11 12.6 1.3 2.6 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zinc-ribbons_6 PF07191.12 CCM00819.1 - 0.79 9.7 15.9 2.7 8.0 6.8 2.4 2 0 0 2 2 2 0 zinc-ribbons zf-RING_10 PF16685.5 CCM00819.1 - 1.3 9.2 17.3 0.56 10.4 7.9 2.6 2 0 0 2 2 2 0 zinc RING finger of MSL2 DUF3072 PF11272.8 CCM00819.1 - 1.4 8.9 5.3 1.5 8.8 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) Amidase PF01425.21 CCM00820.1 - 2.7e-77 260.6 0.0 3e-74 250.6 0.0 2.1 1 1 1 2 2 2 2 Amidase ADH_N PF08240.12 CCM00820.1 - 7.2e-21 74.1 0.2 1.4e-20 73.2 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM00820.1 - 2.6e-14 53.3 0.0 6e-14 52.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCM00820.1 - 4.3e-09 36.2 0.1 1.2e-08 34.7 0.1 1.8 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCM00820.1 - 0.00031 21.8 0.0 0.00068 20.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PARP PF00644.20 CCM00821.1 - 5.6e-06 26.1 0.0 6.9e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain CHGN PF05679.16 CCM00821.1 - 0.0036 16.2 0.0 0.004 16.0 0.0 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase PlyB_C PF18684.1 CCM00822.1 - 9.7e-05 22.2 0.1 0.00025 20.8 0.0 1.7 2 0 0 2 2 2 1 Pleurotolysin B C-terminal domain EIID-AGA PF03613.14 CCM00822.1 - 0.023 13.9 0.1 0.036 13.2 0.1 1.2 1 0 0 1 1 1 0 PTS system mannose/fructose/sorbose family IID component F-box-like PF12937.7 CCM00823.1 - 0.0034 17.3 1.3 0.048 13.6 0.2 3.1 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CCM00823.1 - 0.24 11.3 1.9 0.35 10.8 0.1 2.2 2 0 0 2 2 2 0 F-box domain DUF302 PF03625.14 CCM00825.1 - 8.4e-06 25.6 0.0 2.1e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function DUF302 F-box-like PF12937.7 CCM00826.1 - 0.00091 19.1 2.0 0.0013 18.6 0.4 2.1 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 CCM00826.1 - 1.4 9.1 3.3 27 5.1 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich repeat PGM_PMM_I PF02878.16 CCM00827.1 - 9.1e-32 109.6 0.2 1.5e-31 108.9 0.2 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CCM00827.1 - 5.9e-25 87.7 0.0 1.4e-24 86.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CCM00827.1 - 1.1e-13 51.7 0.0 2.9e-13 50.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CCM00827.1 - 0.0029 17.8 0.0 0.0076 16.4 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain S19 PF06756.11 CCM00827.1 - 0.033 14.1 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Chorion protein S19 C-terminal 2OG-FeII_Oxy PF03171.20 CCM00828.1 - 5.1e-16 59.0 0.0 1.2e-15 57.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCM00828.1 - 4.3e-15 56.5 0.0 1.7e-14 54.6 0.0 1.9 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Spt5-NGN PF03439.13 CCM00829.1 - 1.5e-22 79.2 0.0 3.2e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 CCM00829.1 - 2.1e-17 62.4 17.7 2.8e-05 23.9 0.1 8.0 8 0 0 8 8 8 5 KOW motif Spt5_N PF11942.8 CCM00829.1 - 6.5e-17 62.3 14.9 6.5e-17 62.3 14.9 3.2 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 CCM00829.1 - 5.1e-07 30.2 20.3 5.1e-07 30.2 20.3 2.8 2 1 1 3 3 3 1 Spt5 C-terminal nonapeptide repeat binding Spt4 YajC PF02699.15 CCM00829.1 - 0.23 11.4 1.1 1.3 8.9 0.1 2.5 2 0 0 2 2 2 0 Preprotein translocase subunit SPT6_acidic PF14632.6 CCM00829.1 - 4.5 7.9 51.3 0.2 12.3 16.4 2.6 1 1 1 2 2 2 0 Acidic N-terminal SPT6 TFIIF_alpha PF05793.12 CCM00829.1 - 7.6 5.0 33.5 11 4.4 33.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MFS_1 PF07690.16 CCM00830.1 - 5.4e-33 114.4 50.4 2e-32 112.5 50.4 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM00830.1 - 2.6e-13 49.3 14.2 2.6e-13 49.3 14.2 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM00830.1 - 3.3e-12 46.0 12.0 3.3e-12 46.0 12.0 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter LSM PF01423.22 CCM00833.1 - 1.1e-13 50.7 0.2 1.7e-13 50.0 0.2 1.4 1 0 0 1 1 1 1 LSM domain DASH_Spc34 PF08657.10 CCM00833.1 - 0.032 14.0 1.0 0.28 10.9 0.0 2.2 1 1 0 2 2 2 0 DASH complex subunit Spc34 V-SNARE_C PF12352.8 CCM00833.1 - 0.14 12.4 0.4 0.44 10.9 0.0 1.9 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus SM-ATX PF14438.6 CCM00833.1 - 0.17 12.1 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Ataxin 2 SM domain OmpH PF03938.14 CCM00833.1 - 0.17 12.2 0.6 0.29 11.5 0.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Pro-kuma_activ PF09286.11 CCM00835.1 - 1.6e-36 125.7 0.0 3.4e-36 124.7 0.0 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain MyTH4 PF00784.17 CCM00835.1 - 9.7e-29 100.0 0.0 3.1e-28 98.4 0.0 1.9 1 0 0 1 1 1 1 MyTH4 domain RhoGAP PF00620.27 CCM00835.1 - 1.9e-28 99.2 0.0 3.2e-28 98.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain WW PF00397.26 CCM00835.1 - 6.9e-11 42.0 4.8 2.1e-06 27.7 2.6 2.6 2 0 0 2 2 2 2 WW domain Aldedh PF00171.22 CCM00836.1 - 2.2e-119 399.0 4.8 2.6e-119 398.8 4.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCM00836.1 - 0.015 14.3 1.4 0.028 13.5 0.0 1.8 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) SWIRM-assoc_3 PF16498.5 CCM00836.1 - 0.027 14.7 0.0 0.079 13.2 0.0 1.9 1 0 0 1 1 1 0 SWIRM-associated domain at the C-terminal OmdA PF13376.6 CCM00836.1 - 0.13 12.3 0.7 0.27 11.3 0.7 1.5 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated ComA PF02679.15 CCM00837.1 - 2e-77 259.9 0.0 2.4e-77 259.7 0.0 1.0 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) Pro-kuma_activ PF09286.11 CCM00838.1 - 2.4e-30 105.7 0.1 9.1e-30 103.8 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM00838.1 - 5.1e-05 22.7 2.1 8.6e-05 21.9 1.8 1.6 2 0 0 2 2 2 1 Subtilase family tRNA-synt_2 PF00152.20 CCM00839.1 - 6.5e-68 229.1 0.2 1.2e-67 228.3 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 CCM00839.1 - 9.5e-19 67.5 0.0 1.4e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA-synt_2d PF01409.20 CCM00839.1 - 0.013 15.0 0.2 3 7.2 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Pro-kuma_activ PF09286.11 CCM00840.1 - 5.9e-32 110.9 0.1 1.1e-31 110.0 0.1 1.5 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM00840.1 - 0.00031 20.1 0.2 0.00059 19.2 0.2 1.4 1 0 0 1 1 1 1 Subtilase family DUF1932 PF09130.11 CCM00841.1 - 1.7e-17 63.1 0.0 4.6e-17 61.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) NAD_binding_2 PF03446.15 CCM00841.1 - 5.1e-07 30.0 0.0 9.2e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CCM00841.1 - 1.6e-05 24.3 0.0 2.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCM00841.1 - 0.00036 21.1 0.1 0.0012 19.4 0.1 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CCM00841.1 - 0.0016 18.3 0.2 0.0034 17.3 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 CCM00841.1 - 0.0018 17.9 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Rossmann-like PF10727.9 CCM00841.1 - 0.032 14.1 1.1 0.067 13.1 1.1 1.6 1 0 0 1 1 1 0 Rossmann-like domain Shikimate_DH PF01488.20 CCM00841.1 - 0.078 13.0 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase G-alpha PF00503.20 CCM00842.1 - 1.2e-108 363.4 0.0 1.7e-108 363.0 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCM00842.1 - 1.2e-10 41.1 0.0 4.7e-07 29.4 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM00842.1 - 0.026 14.1 0.0 0.96 9.0 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 CCM00842.1 - 0.06 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCM00842.1 - 0.069 12.4 0.1 0.14 11.4 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin TniB PF05621.11 CCM00842.1 - 0.089 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 CCM00842.1 - 0.1 12.8 0.0 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 CCM00842.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 CCM00842.1 - 0.14 11.9 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ribosomal_L18A PF01775.17 CCM00842.1 - 0.15 12.2 0.7 0.7 10.0 0.2 2.1 2 0 0 2 2 2 0 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Form_Nir_trans PF01226.17 CCM00843.1 - 8.1e-73 244.6 15.3 3.8e-45 154.1 6.8 2.0 1 1 1 2 2 2 2 Formate/nitrite transporter TM_helix PF05552.12 CCM00843.1 - 0.08 12.9 1.1 0.23 11.5 1.1 1.8 1 0 0 1 1 1 0 Conserved TM helix DSPc PF00782.20 CCM00844.1 - 3.6e-27 94.8 0.0 4.8e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCM00844.1 - 0.038 13.5 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DHDPS PF00701.22 CCM00845.1 - 3.2e-26 91.7 0.0 1.2e-25 89.8 0.0 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family HET PF06985.11 CCM00849.1 - 6.3e-36 123.9 0.1 1.5e-35 122.6 0.0 1.7 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) ABA_GPCR PF12430.8 CCM00850.1 - 2.1e-40 138.4 0.3 2.1e-40 138.4 0.3 2.2 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 CCM00850.1 - 1.1e-14 54.2 0.0 3.2e-14 52.8 0.0 1.9 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal Spore_permease PF03845.13 CCM00850.1 - 0.018 13.9 0.7 0.018 13.9 0.7 1.8 2 0 0 2 2 2 0 Spore germination protein Heliorhodopsin PF18761.1 CCM00850.1 - 3 7.1 5.8 0.33 10.2 1.3 1.6 2 0 0 2 2 2 0 Heliorhodopsin Sugar_tr PF00083.24 CCM00851.1 - 1.3e-87 294.5 19.0 1.5e-87 294.3 19.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM00851.1 - 3.8e-20 72.1 41.4 1.1e-12 47.6 22.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCM00851.1 - 0.0056 15.2 4.5 0.0088 14.5 4.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ACPS PF01648.20 CCM00852.1 - 0.0044 17.1 0.0 0.0099 16.0 0.0 1.7 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Sugar_tr PF00083.24 CCM00853.1 - 1.5e-76 258.1 17.8 5e-69 233.3 10.0 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCM00853.1 - 1.6e-14 53.6 22.8 3.4e-09 36.1 10.0 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily F-box-like PF12937.7 CCM00855.1 - 0.00019 21.2 0.0 0.00058 19.7 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM00855.1 - 0.055 13.4 0.2 7.4 6.6 0.1 3.1 2 0 0 2 2 2 0 F-box domain p450 PF00067.22 CCM00858.1 - 1.1e-84 284.8 0.0 1.3e-84 284.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Spc7_C2 PF15577.6 CCM00860.1 - 0.18 11.9 0.5 0.3 11.2 0.0 1.6 2 0 0 2 2 2 0 Spc7_C2 DUF3328 PF11807.8 CCM00861.1 - 8.8e-22 78.0 0.0 1.3e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) GWT1 PF06423.12 CCM00862.1 - 3e-29 102.1 0.0 6.9e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 GWT1 DUF2178 PF09946.9 CCM00862.1 - 0.099 12.8 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) TauD PF02668.16 CCM00864.1 - 7.6e-46 157.1 0.1 1.1e-45 156.6 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family F-box-like PF12937.7 CCM00865.1 - 0.024 14.5 0.1 0.066 13.1 0.1 1.8 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 CCM00865.1 - 0.027 14.3 0.3 0.21 11.5 0.3 2.5 1 1 0 1 1 1 0 F-box domain FAD_binding_4 PF01565.23 CCM00866.1 - 2.1e-21 76.1 1.6 3.7e-21 75.3 1.6 1.4 1 0 0 1 1 1 1 FAD binding domain ADH_zinc_N PF00107.26 CCM00867.1 - 5.3e-19 68.5 0.0 1.9e-18 66.7 0.0 1.9 2 1 1 3 3 3 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCM00867.1 - 3.3e-15 55.9 0.0 7.5e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CCM00867.1 - 3.7e-08 34.5 0.0 1.5e-07 32.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCM00868.1 - 3.1e-20 72.5 0.0 6e-20 71.5 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCM00868.1 - 1.8e-17 63.2 0.0 5.4e-17 61.7 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CCM00868.1 - 7e-07 30.4 0.0 1.2e-06 29.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 CCM00868.1 - 0.045 13.5 0.1 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2855) p450 PF00067.22 CCM00869.1 - 2.2e-64 217.9 0.0 3.5e-64 217.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Phage_lambda_P PF06992.11 CCM00869.1 - 0.059 13.1 0.0 0.76 9.5 0.0 2.5 3 0 0 3 3 3 0 Replication protein P DUF5510 PF17629.2 CCM00869.1 - 0.1 12.6 0.2 0.2 11.6 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5510) Aldo_ket_red PF00248.21 CCM00870.1 - 4.3e-27 95.1 0.0 5.6e-19 68.4 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family MFS_1 PF07690.16 CCM00871.1 - 1.7e-38 132.4 30.6 1.7e-38 132.4 30.6 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM00871.1 - 1.2e-06 27.7 4.8 1.2e-06 27.7 4.8 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter F-box-like PF12937.7 CCM00872.1 - 0.019 14.8 0.1 0.051 13.5 0.1 1.7 1 0 0 1 1 1 0 F-box-like FAD_binding_4 PF01565.23 CCM00874.1 - 1.7e-21 76.4 4.6 3.1e-21 75.6 4.6 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCM00874.1 - 0.028 14.5 0.0 0.071 13.2 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like p450 PF00067.22 CCM00875.1 - 3.6e-48 164.5 0.1 4.6e-48 164.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 CCM00876.1 - 0.14 12.0 1.1 0.42 10.6 1.1 1.9 1 0 0 1 1 1 0 F-box-like UPF0556 PF10572.9 CCM00878.1 - 0.2 11.2 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0556 F-box PF00646.33 CCM00879.1 - 0.052 13.4 0.0 0.29 11.1 0.0 2.3 2 1 0 2 2 2 0 F-box domain IQ PF00612.27 CCM00879.1 - 0.13 12.1 0.9 0.4 10.6 0.9 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif F-box-like PF12937.7 CCM00880.1 - 0.0011 18.8 0.0 0.015 15.2 0.0 2.4 1 1 0 2 2 2 1 F-box-like F-box PF00646.33 CCM00880.1 - 0.012 15.5 0.6 0.34 10.9 0.6 2.9 1 1 0 1 1 1 0 F-box domain Hydrolase_4 PF12146.8 CCM00883.1 - 1.2e-05 24.7 0.0 0.0012 18.2 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCM00883.1 - 4.3e-05 23.3 0.0 0.0001 22.1 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold LRR_4 PF12799.7 CCM00884.1 - 0.79 10.2 6.1 0.76 10.3 0.2 3.9 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) Aa_trans PF01490.18 CCM00885.1 - 2.5e-33 115.4 37.2 2.8e-33 115.2 37.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein GTA_holin_3TM PF11351.8 CCM00885.1 - 0.95 10.0 3.1 35 4.9 0.0 2.6 2 1 0 2 2 2 0 Holin of 3TMs, for gene-transfer release Bap31 PF05529.12 CCM00885.1 - 1.1 9.1 4.9 0.25 11.2 0.9 2.1 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region Acyltransferase PF01553.21 CCM00886.1 - 6.8e-21 74.3 0.0 1.1e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CCM00886.1 - 6.8e-09 35.7 0.0 6.3e-07 29.4 0.0 2.5 2 0 0 2 2 2 2 Acyltransferase C-terminus zf-Tim10_DDP PF02953.15 CCM00887.1 - 6.8e-23 80.1 1.4 8.6e-23 79.8 1.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger R3H-assoc PF13902.6 CCM00888.1 - 0.065 13.6 0.4 0.63 10.4 0.1 2.2 2 0 0 2 2 2 0 R3H-associated N-terminal domain MRP_L53 PF10780.9 CCM00889.1 - 1.3 9.2 4.5 1.1 9.5 0.5 2.9 3 0 0 3 3 3 0 39S ribosomal protein L53/MRP-L53 AlaDh_PNT_N PF05222.15 CCM00890.1 - 4.9e-22 78.7 0.0 5.4e-21 75.3 0.0 2.1 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 CCM00890.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain WD40_4 PF16300.5 CCM00890.1 - 0.1 12.5 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Type of WD40 repeat DUF5060 PF16586.5 CCM00890.1 - 0.17 12.2 0.0 3.4 8.1 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) Peptidase_M22 PF00814.25 CCM00891.1 - 3e-83 279.6 0.0 3.7e-83 279.3 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CCM00891.1 - 0.11 12.2 0.0 1.6 8.3 0.0 2.0 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus Glyco_transf_8 PF01501.20 CCM00892.1 - 9.4e-16 58.1 0.0 1.7e-15 57.3 0.0 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 CCM00892.1 - 0.0041 16.5 0.0 0.0057 16.1 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative VirE_N PF08800.10 CCM00892.1 - 0.13 12.4 0.1 15 5.7 0.1 2.2 2 0 0 2 2 2 0 VirE N-terminal domain LIAS_N PF16881.5 CCM00893.1 - 2.4e-26 92.2 0.0 2.2e-25 89.1 0.0 2.4 3 0 0 3 3 3 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 CCM00893.1 - 3.7e-13 50.2 0.0 6.3e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily PEX11 PF05648.14 CCM00894.1 - 4.2e-47 160.5 0.2 4.2e-47 160.5 0.2 1.3 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) Phasin PF05597.11 CCM00894.1 - 0.096 12.7 0.3 0.3 11.1 0.3 1.8 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Lyase_1 PF00206.20 CCM00895.1 - 3e-120 401.3 0.0 5.7e-120 400.4 0.0 1.4 2 0 0 2 2 2 1 Lyase FumaraseC_C PF10415.9 CCM00895.1 - 2.7e-20 72.5 0.1 6.1e-20 71.4 0.1 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus ADH_N PF08240.12 CCM00895.1 - 0.057 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain SNF2_N PF00176.23 CCM00896.1 - 4e-67 226.4 1.0 1e-66 225.1 1.0 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 CCM00896.1 - 5.2e-51 172.5 16.0 5.2e-51 172.5 16.0 2.3 2 0 0 2 2 2 1 DNA-binding domain Helicase_C PF00271.31 CCM00896.1 - 1.3e-15 57.7 0.0 3.2e-15 56.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM00896.1 - 1.7e-06 28.1 0.0 4e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CCM00896.1 - 4.2e-05 22.9 0.1 0.0006 19.1 0.0 2.5 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 HA2 PF04408.23 CCM00897.1 - 1.4e-14 54.3 0.1 5.1e-14 52.5 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCM00897.1 - 2.6e-14 53.5 0.0 7e-14 52.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CCM00897.1 - 4.1e-11 43.1 0.0 9.6e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 CCM00897.1 - 0.00019 21.7 0.0 0.00061 20.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CCM00897.1 - 0.041 14.4 0.0 0.14 12.6 0.0 1.9 1 0 0 1 1 1 0 ABC transporter Rad17 PF03215.15 CCM00897.1 - 0.23 11.3 0.4 0.64 9.9 0.0 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain Ribosomal_L22e PF01776.17 CCM00898.1 - 4.8e-46 155.6 0.3 6.2e-46 155.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family DKCLD PF08068.12 CCM00899.1 - 1.2e-32 111.7 0.1 8.5e-32 109.0 0.2 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 CCM00899.1 - 1.4e-20 74.1 0.2 2.5e-16 60.4 0.1 3.0 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 CCM00899.1 - 2.4e-17 62.6 0.2 4.6e-17 61.7 0.2 1.5 1 0 0 1 1 1 1 PUA domain TruB_C_2 PF16198.5 CCM00899.1 - 9.2e-16 57.8 0.1 2.1e-15 56.6 0.1 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Pkinase PF00069.25 CCM00901.1 - 4.2e-59 200.1 0.0 4.9e-59 199.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00901.1 - 2.1e-22 79.7 0.0 2.7e-22 79.3 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCM00901.1 - 0.0033 16.8 0.1 0.0058 16.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM00901.1 - 0.022 14.7 0.1 0.051 13.5 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCM00901.1 - 0.023 13.6 0.0 0.035 13.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 CCM00901.1 - 0.03 13.6 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 CCM00901.1 - 0.054 13.1 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 RIO1 family NPV_P10 PF05531.12 CCM00902.1 - 0.00025 21.5 1.7 0.00065 20.1 1.7 1.7 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein LPP PF04728.13 CCM00902.1 - 0.0019 18.6 2.6 0.39 11.1 0.2 3.1 1 1 1 2 2 2 1 Lipoprotein leucine-zipper FlxA PF14282.6 CCM00902.1 - 0.003 17.5 10.2 0.2 11.7 0.4 2.6 1 1 1 2 2 2 2 FlxA-like protein CENP-F_leu_zip PF10473.9 CCM00902.1 - 0.007 16.4 2.2 0.013 15.6 2.2 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NleF_casp_inhib PF16809.5 CCM00902.1 - 0.011 15.6 1.2 0.019 14.9 1.2 1.3 1 0 0 1 1 1 0 NleF caspase inhibitor DUF4763 PF15960.5 CCM00902.1 - 0.017 14.5 1.4 0.028 13.7 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) DASH_Dam1 PF08653.10 CCM00902.1 - 0.018 14.8 1.0 0.37 10.6 0.1 2.3 1 1 1 2 2 2 0 DASH complex subunit Dam1 Spc7 PF08317.11 CCM00902.1 - 0.025 13.5 2.8 0.038 12.9 2.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Fzo_mitofusin PF04799.13 CCM00902.1 - 0.025 14.1 2.0 0.038 13.5 1.0 1.7 1 1 1 2 2 2 0 fzo-like conserved region GAS PF13851.6 CCM00902.1 - 0.041 13.2 1.3 0.064 12.6 1.3 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding OmpH PF03938.14 CCM00902.1 - 0.044 14.1 3.0 0.089 13.1 3.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PIN_8 PF18476.1 CCM00902.1 - 0.049 13.5 0.2 0.078 12.8 0.2 1.2 1 0 0 1 1 1 0 PIN like domain HBM PF16591.5 CCM00902.1 - 0.054 12.9 3.4 0.093 12.1 3.4 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain Dor1 PF04124.12 CCM00902.1 - 0.059 12.0 1.5 0.086 11.5 1.5 1.1 1 0 0 1 1 1 0 Dor1-like family FerA PF08165.11 CCM00902.1 - 0.064 13.2 1.8 0.17 11.8 1.2 2.0 1 1 0 1 1 1 0 FerA (NUC095) domain NPR3 PF03666.13 CCM00902.1 - 0.07 11.9 0.3 0.13 11.1 0.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BLOC1_2 PF10046.9 CCM00902.1 - 0.074 13.4 2.9 0.24 11.7 2.8 1.8 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fez1 PF06818.15 CCM00902.1 - 0.079 13.4 1.3 0.12 12.8 1.3 1.4 1 0 0 1 1 1 0 Fez1 DUF3450 PF11932.8 CCM00902.1 - 0.088 12.1 4.2 0.14 11.4 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Allexi_40kDa PF05549.11 CCM00902.1 - 0.092 12.3 2.5 0.16 11.5 2.5 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein SAP PF02037.27 CCM00902.1 - 0.11 12.3 0.4 0.24 11.2 0.4 1.6 1 0 0 1 1 1 0 SAP domain HALZ PF02183.18 CCM00902.1 - 0.11 12.7 1.4 5.7 7.2 0.4 2.4 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF948 PF06103.11 CCM00902.1 - 0.11 12.8 1.6 0.21 11.9 1.6 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 CCM00902.1 - 0.12 12.6 3.5 0.22 11.7 3.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Bap31_Bap29_C PF18035.1 CCM00902.1 - 0.12 12.4 0.5 0.32 11.0 0.4 1.7 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain TMF_DNA_bd PF12329.8 CCM00902.1 - 0.12 12.4 1.6 0.48 10.4 1.6 2.1 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4618 PF15397.6 CCM00902.1 - 0.13 11.7 2.9 0.61 9.4 1.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) ZapB PF06005.12 CCM00902.1 - 0.13 12.7 2.9 0.53 10.8 2.9 2.0 1 1 0 1 1 1 0 Cell division protein ZapB Baculo_PEP_C PF04513.12 CCM00902.1 - 0.15 12.1 6.2 0.21 11.6 4.7 1.9 2 1 0 2 2 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus RPW8 PF05659.11 CCM00902.1 - 0.15 11.7 0.8 0.26 11.0 0.8 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Spc42p PF11544.8 CCM00902.1 - 0.16 12.0 0.4 0.48 10.4 0.0 1.9 2 0 0 2 2 1 0 Spindle pole body component Spc42p Laminin_II PF06009.12 CCM00902.1 - 0.19 11.7 2.3 0.39 10.7 2.3 1.4 1 0 0 1 1 1 0 Laminin Domain II CLZ PF16526.5 CCM00902.1 - 0.24 11.8 3.6 1.2 9.6 0.6 2.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YabA PF06156.13 CCM00902.1 - 0.25 12.0 2.4 1.7 9.3 2.4 2.1 1 1 0 1 1 1 0 Initiation control protein YabA Filament PF00038.21 CCM00902.1 - 0.28 10.7 4.1 0.43 10.1 4.1 1.2 1 0 0 1 1 1 0 Intermediate filament protein Prefoldin PF02996.17 CCM00902.1 - 0.29 11.1 3.4 2.8 7.9 0.7 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF3573 PF12097.8 CCM00902.1 - 0.3 9.9 0.6 0.53 9.0 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DivIC PF04977.15 CCM00902.1 - 0.4 10.5 3.9 4.8 7.0 1.4 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF1192 PF06698.11 CCM00902.1 - 0.4 10.8 1.9 4.8 7.3 0.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1192) TSNAXIP1_N PF15739.5 CCM00902.1 - 0.54 10.7 1.9 1.1 9.7 1.9 1.4 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus TolA_bind_tri PF16331.5 CCM00902.1 - 0.56 10.3 6.7 7.8 6.7 5.7 2.4 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF4140 PF13600.6 CCM00902.1 - 0.57 10.6 5.7 1.9 8.9 2.0 2.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) ABC_tran_CTD PF16326.5 CCM00902.1 - 0.61 10.4 3.8 1.1 9.6 2.9 1.9 1 1 0 1 1 1 0 ABC transporter C-terminal domain COG5 PF10392.9 CCM00902.1 - 0.61 10.3 3.2 2.2 8.5 1.1 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Surfac_D-trimer PF09006.11 CCM00902.1 - 0.63 10.0 2.4 7.2 6.6 0.5 2.7 1 1 2 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation IFP_35_N PF07334.13 CCM00902.1 - 0.64 10.1 2.6 3.2 7.9 1.1 2.6 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4407 PF14362.6 CCM00902.1 - 0.91 8.8 5.6 0.48 9.7 1.6 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) T2SSM PF04612.12 CCM00902.1 - 1.1 9.3 7.6 0.27 11.3 1.8 2.5 2 1 1 3 3 2 0 Type II secretion system (T2SS), protein M BORCS6 PF10157.9 CCM00902.1 - 1.2 9.3 5.2 0.46 10.7 1.8 2.0 2 1 0 2 2 1 0 BLOC-1-related complex sub-unit 6 Csm1_N PF18504.1 CCM00902.1 - 2 8.8 3.8 14 6.1 0.8 2.8 1 1 2 3 3 3 0 Csm1 N-terminal domain BST2 PF16716.5 CCM00902.1 - 2.1 9.0 5.5 10 6.8 3.2 2.3 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 ATG16 PF08614.11 CCM00902.1 - 3.9 7.7 12.5 0.18 12.0 6.6 1.8 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) RP-C_C PF11800.8 CCM00902.1 - 5.5 7.0 8.6 29 4.7 8.6 2.2 1 1 0 1 1 1 0 Replication protein C C-terminal region FMN_dh PF01070.18 CCM00903.1 - 1.7e-99 333.2 0.0 2.1e-99 332.9 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCM00903.1 - 1.7e-21 76.1 0.0 4.2e-21 74.9 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 CCM00903.1 - 0.0014 17.7 0.2 0.0041 16.2 0.2 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CCM00903.1 - 0.0027 17.1 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 CCM00903.1 - 0.028 13.5 0.0 0.081 12.0 0.0 1.7 1 0 0 1 1 1 0 Conserved region in glutamate synthase FMN_dh PF01070.18 CCM00904.1 - 1.8e-107 359.4 0.0 2.3e-107 359.1 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CCM00904.1 - 2e-19 69.5 0.0 4.1e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CCM00904.1 - 4.1e-05 22.9 0.1 0.0001 21.6 0.0 1.7 2 0 0 2 2 2 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCM00904.1 - 7.2e-05 21.9 0.0 0.00012 21.2 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CCM00904.1 - 0.022 14.2 0.1 0.061 12.7 0.0 1.7 2 0 0 2 2 2 0 Nitronate monooxygenase ThiG PF05690.14 CCM00904.1 - 0.11 11.8 0.1 4.2 6.6 0.1 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Formyl_trans_N PF00551.19 CCM00905.1 - 9.7e-36 123.2 0.0 1.5e-34 119.3 0.0 2.0 1 1 0 1 1 1 1 Formyl transferase DnaJ PF00226.31 CCM00907.1 - 1.3e-18 66.8 2.1 2.1e-18 66.2 2.1 1.3 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 CCM00907.1 - 0.016 15.5 2.0 0.028 14.7 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Rick_17kDa_Anti PF05433.15 CCM00907.1 - 1.6 8.7 0.0 1.6 8.7 0.0 3.6 4 0 0 4 4 4 0 Glycine zipper 2TM domain LIM PF00412.22 CCM00910.1 - 5.4e-13 49.0 25.2 2.9e-06 27.4 5.6 5.3 5 1 0 5 5 5 3 LIM domain Sin_N PF04801.13 CCM00911.1 - 1.8e-21 76.9 0.0 2.3e-21 76.5 0.0 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region AAA_18 PF13238.6 CCM00913.1 - 6.3e-30 104.4 0.0 9.7e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCM00913.1 - 5.8e-05 23.5 0.0 0.00022 21.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCM00913.1 - 6.7e-05 23.1 0.0 0.014 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 CCM00913.1 - 0.00026 20.9 0.0 0.26 11.1 0.0 2.1 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA PF00004.29 CCM00913.1 - 0.0004 20.8 0.0 0.00095 19.6 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CCM00913.1 - 0.001 19.4 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 CCM00913.1 - 0.0025 17.7 0.0 0.0042 16.9 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Thymidylate_kin PF02223.17 CCM00913.1 - 0.0052 16.5 0.0 2.4 7.8 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_22 PF13401.6 CCM00913.1 - 0.0064 16.8 0.0 0.012 15.8 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCM00913.1 - 0.0082 16.5 0.1 0.015 15.7 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.10 CCM00913.1 - 0.0086 15.6 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ADK PF00406.22 CCM00913.1 - 0.012 15.7 0.0 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 Adenylate kinase AAA_5 PF07728.14 CCM00913.1 - 0.015 15.3 0.0 0.033 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 CCM00913.1 - 0.027 14.8 0.3 0.067 13.5 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCM00913.1 - 0.029 14.1 0.1 0.058 13.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CCM00913.1 - 0.043 12.8 0.2 0.1 11.5 0.1 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Sigma54_activ_2 PF14532.6 CCM00913.1 - 0.05 13.7 0.0 0.12 12.5 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 CCM00913.1 - 0.05 13.3 0.1 0.066 12.9 0.1 1.4 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CCM00913.1 - 0.09 12.7 0.5 0.37 10.7 0.2 1.9 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 CCM00913.1 - 0.099 11.9 0.1 0.27 10.5 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin ATPase PF06745.13 CCM00913.1 - 0.14 11.4 0.1 0.82 9.0 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_25 PF13481.6 CCM00913.1 - 0.2 11.2 1.4 0.6 9.7 0.3 2.1 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CCM00913.1 - 0.23 11.2 0.0 0.39 10.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain PAPA-1 PF04795.12 CCM00915.1 - 2.1e-18 66.9 5.1 2.1e-18 66.9 5.1 2.5 2 0 0 2 2 2 1 PAPA-1-like conserved region HTH_23 PF13384.6 CCM00915.1 - 0.11 12.4 2.9 0.19 11.6 0.0 2.8 3 0 0 3 3 3 0 Homeodomain-like domain DUF4232 PF14016.6 CCM00916.1 - 0.089 12.9 7.3 0.086 13.0 5.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4232) Cyclin_C_2 PF16899.5 CCM00917.1 - 1e-20 74.0 0.2 8.8e-19 67.8 0.0 2.3 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 CCM00917.1 - 1.2e-06 28.2 0.1 2.7e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Amidohydro_1 PF01979.20 CCM00917.1 - 0.041 13.2 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase family GYF PF02213.16 CCM00918.1 - 2e-13 49.8 0.0 4e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 GYF domain zf-C2H2 PF00096.26 CCM00919.1 - 8e-17 60.7 24.8 0.0011 19.3 0.1 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM00919.1 - 1.6e-14 53.3 21.1 0.034 15.0 0.1 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf_ZIC PF18366.1 CCM00919.1 - 4.1e-05 23.6 1.2 0.5 10.5 0.0 3.9 4 0 0 4 4 4 2 Zic proteins zinc finger domain zf-C2H2_6 PF13912.6 CCM00919.1 - 0.00042 20.2 6.2 1.4 9.0 0.4 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCM00919.1 - 0.0048 17.2 4.7 2.4 8.5 0.0 4.0 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM00919.1 - 0.0051 17.2 0.5 38 4.9 0.0 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 CCM00919.1 - 0.0066 16.7 0.7 1.3 9.4 0.1 2.5 2 0 0 2 2 2 1 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 CCM00919.1 - 0.057 13.2 8.1 12 5.7 0.4 4.7 4 0 0 4 4 4 0 C2H2-type zinc-finger domain DUF4729 PF15866.5 CCM00919.1 - 0.062 12.6 0.6 1.9 7.7 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4729) IBR PF01485.21 CCM00919.1 - 0.13 12.5 3.7 9.1 6.6 0.9 3.4 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain ARS2 PF04959.13 CCM00919.1 - 7.8 6.8 6.2 6.6 7.1 0.0 3.1 2 1 2 4 4 4 0 Arsenite-resistance protein 2 Alginate_lyase PF05426.12 CCM00920.1 - 5.7e-51 173.7 0.6 4.6e-49 167.4 0.3 2.1 2 0 0 2 2 2 2 Alginate lyase Ras PF00071.22 CCM00921.1 - 2.9e-54 183.1 0.0 3.8e-54 182.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM00921.1 - 1.5e-33 115.5 0.0 2.1e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM00921.1 - 6.2e-14 51.8 0.0 1.5e-13 50.6 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM00921.1 - 6.1e-06 25.8 0.0 7.6e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM00921.1 - 0.00011 22.3 0.0 0.00016 21.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCM00921.1 - 0.00017 21.2 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCM00921.1 - 0.00033 21.1 0.6 0.00058 20.3 0.6 1.4 1 1 0 1 1 1 1 AAA ATPase domain Arrestin_C PF02752.22 CCM00922.1 - 0.00022 21.7 0.0 0.0005 20.5 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain DUF1764 PF08576.10 CCM00923.1 - 6.2e-20 72.0 6.9 8.6e-19 68.3 1.5 2.1 1 1 0 2 2 2 2 Eukaryotic protein of unknown function (DUF1764) Med3 PF11593.8 CCM00923.1 - 0.62 9.2 3.8 0.73 9.0 3.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal ORC6 PF05460.13 CCM00923.1 - 9.8 5.3 9.3 12 5.1 9.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) BAF250_C PF12031.8 CCM00924.1 - 3.1e-06 26.7 1.5 8.8e-05 21.9 1.1 2.7 2 1 0 2 2 2 1 SWI/SNF-like complex subunit BAF250/Osa WD40 PF00400.32 CCM00925.1 - 4.2e-08 33.7 3.4 0.076 13.9 0.1 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00925.1 - 0.023 15.0 0.0 1.1 9.6 0.0 3.4 3 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain FAD-oxidase_C PF02913.19 CCM00926.1 - 2.8e-58 197.5 0.0 4.2e-58 196.9 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCM00926.1 - 1.7e-33 115.3 0.4 3.4e-33 114.3 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain BRCT_2 PF16589.5 CCM00926.1 - 1.3e-10 41.5 0.0 0.00012 22.4 0.0 2.7 1 1 1 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-bind_2 PF08914.11 CCM00926.1 - 1.8e-09 37.7 1.0 4.8e-09 36.3 1.0 1.8 1 0 0 1 1 1 1 Rap1 Myb domain EFG_II PF14492.6 CCM00926.1 - 0.03 14.4 1.0 0.42 10.7 0.0 2.9 3 0 0 3 3 3 0 Elongation Factor G, domain II Rap1-DNA-bind PF09197.10 CCM00926.1 - 5.1 7.7 5.3 6.4 7.4 2.5 2.5 2 1 0 3 3 3 0 Rap1, DNA-binding Pkinase PF00069.25 CCM00927.1 - 2.2e-66 223.9 0.0 2.7e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM00927.1 - 1.2e-26 93.6 0.0 1.6e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM00927.1 - 2.2e-06 27.2 0.1 0.001 18.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 CCM00927.1 - 0.0024 17.5 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 CCM00927.1 - 0.11 11.4 0.1 0.21 10.5 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Mod_r PF07200.13 CCM00928.1 - 0.0044 17.1 2.8 0.0044 17.1 2.8 1.9 1 1 1 2 2 2 1 Modifier of rudimentary (Mod(r)) protein Cnn_1N PF07989.11 CCM00928.1 - 0.0049 17.0 8.1 0.015 15.4 8.1 1.8 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 CENP-H PF05837.12 CCM00928.1 - 0.0087 16.5 8.5 0.018 15.5 8.5 1.5 1 1 0 1 1 1 1 Centromere protein H (CENP-H) bZIP_1 PF00170.21 CCM00928.1 - 0.018 15.1 1.7 0.018 15.1 1.7 1.9 2 0 0 2 2 2 0 bZIP transcription factor CCDC-167 PF15188.6 CCM00928.1 - 0.036 14.4 4.0 0.056 13.8 4.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF1850 PF08905.11 CCM00928.1 - 0.056 13.8 0.0 0.079 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1850) LRS4 PF10422.9 CCM00928.1 - 0.071 12.7 6.3 0.081 12.5 6.3 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 CC2-LZ PF16516.5 CCM00928.1 - 0.1 12.9 7.4 0.045 14.1 3.3 1.9 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator UPF0242 PF06785.11 CCM00928.1 - 0.12 12.5 5.7 0.17 12.0 5.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 CCM00928.1 - 0.13 12.9 7.1 0.23 12.1 6.1 1.8 1 1 1 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 CCM00928.1 - 0.15 11.4 3.9 0.16 11.3 3.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Viral_P18 PF04521.13 CCM00928.1 - 0.21 11.4 2.0 0.25 11.1 1.2 1.5 1 1 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein Atg14 PF10186.9 CCM00928.1 - 0.52 9.3 6.0 0.58 9.2 6.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 CCM00928.1 - 2.9 7.7 6.7 0.7 9.7 2.1 2.0 2 0 0 2 2 2 0 Septum formation initiator MMM1 PF10296.9 CCM00929.1 - 2.2e-33 115.7 0.1 6.5e-24 84.6 0.0 3.0 1 1 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 TTL PF03133.15 CCM00930.1 - 2.6e-44 151.5 0.0 9.3e-30 103.8 0.0 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family RNA_pol_Rpb8 PF03870.15 CCM00930.1 - 2e-36 125.2 0.0 3.4e-36 124.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb8 Con-6 PF10346.9 CCM00931.1 - 4.5e-29 100.2 6.8 3.1e-15 55.9 1.2 2.2 2 0 0 2 2 2 2 Conidiation protein 6 ATP-synt_DE PF00401.20 CCM00931.1 - 0.0077 16.5 1.2 0.014 15.6 1.2 1.5 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain SpoIIIAH PF12685.7 CCM00931.1 - 0.011 15.5 2.6 0.034 14.0 0.4 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein Con-6 PF10346.9 CCM00932.1 - 7.7e-28 96.2 7.0 1.4e-13 50.6 0.7 2.2 2 0 0 2 2 2 2 Conidiation protein 6 Phage_GPD PF05954.11 CCM00932.1 - 0.024 13.9 0.7 0.027 13.8 0.7 1.0 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) ATP-synt_DE PF00401.20 CCM00932.1 - 0.047 14.0 2.9 0.047 14.0 2.9 1.7 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain SpoIIIAH PF12685.7 CCM00932.1 - 0.047 13.5 0.5 0.047 13.5 0.5 1.9 1 1 1 2 2 2 0 SpoIIIAH-like protein Glyco_transf_8C PF08437.10 CCM00932.1 - 0.053 13.6 0.7 6.7 6.9 0.1 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal Sec7 PF01369.20 CCM00934.1 - 8.7e-34 116.8 0.0 1.4e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 CCM00934.1 - 2.1e-13 50.7 0.0 3.9e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CCM00934.1 - 2.5e-09 37.6 0.0 5.6e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 PH domain Pescadillo_N PF06732.11 CCM00936.1 - 1.5e-120 401.8 0.0 3e-120 400.9 0.0 1.4 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 CCM00936.1 - 3.3e-09 37.0 0.0 6.6e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CCM00936.1 - 0.00021 21.5 0.0 0.00061 20.0 0.0 1.8 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT PF00533.26 CCM00936.1 - 0.00065 20.0 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LSM PF01423.22 CCM00937.1 - 2.3e-08 33.6 0.1 4.4e-07 29.5 0.1 2.1 1 1 0 1 1 1 1 LSM domain Hfq PF17209.3 CCM00937.1 - 0.021 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Hfq protein F1F0-ATPsyn_F PF10791.9 CCM00937.1 - 0.045 14.2 0.0 0.082 13.4 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi RdRP PF05183.12 CCM00938.1 - 1.7e-179 598.2 0.0 2.3e-179 597.8 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase Cyclin_N PF00134.23 CCM00940.1 - 1e-37 128.7 0.4 2.3e-37 127.6 0.4 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCM00940.1 - 4e-09 36.6 0.3 9.7e-09 35.3 0.3 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF4364 PF14277.6 CCM00940.1 - 0.0037 17.0 0.1 0.0079 16.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) GFO_IDH_MocA PF01408.22 CCM00941.1 - 9.5e-13 49.0 0.7 5.3e-12 46.6 0.7 2.1 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 CCM00941.1 - 0.022 15.0 0.1 0.067 13.5 0.1 1.7 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GFO_IDH_MocA_C PF02894.17 CCM00941.1 - 0.037 14.0 0.2 0.15 12.1 0.1 2.1 1 1 1 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding_2 PF13380.6 CCM00941.1 - 0.075 13.5 0.1 0.15 12.5 0.1 1.4 1 0 0 1 1 1 0 CoA binding domain NAD_binding_3 PF03447.16 CCM00941.1 - 0.12 13.0 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain SGP PF17228.2 CCM00942.1 - 0.65 10.9 6.6 0.073 13.9 1.5 2.1 2 0 0 2 2 2 0 Sulphur globule protein WAC_Acf1_DNA_bd PF10537.9 CCM00943.1 - 6.4e-32 110.1 0.1 2e-31 108.5 0.1 2.0 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 CCM00943.1 - 8.5e-32 109.6 0.0 8.5e-32 109.6 0.0 2.9 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 CCM00943.1 - 2.3e-15 56.7 0.2 8.2e-15 54.9 0.1 1.9 2 0 0 2 2 2 1 DDT domain WHIM1 PF15612.6 CCM00943.1 - 3.6e-08 32.7 0.0 7.7e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DDHD PF02862.17 CCM00943.1 - 0.0066 16.6 4.1 0.033 14.3 0.1 2.5 3 0 0 3 3 3 1 DDHD domain DUF4407 PF14362.6 CCM00943.1 - 2.3 7.5 8.1 8.6 5.6 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Nop53 PF07767.11 CCM00943.1 - 4.9 6.5 33.0 0.88 8.9 15.6 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Aa_trans PF01490.18 CCM00944.1 - 5.6e-49 166.9 17.6 9.5e-49 166.2 17.6 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein CSN8_PSD8_EIF3K PF10075.9 CCM00945.1 - 2.6e-23 82.6 0.0 3.5e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family WD40 PF00400.32 CCM00946.1 - 1.1e-60 200.1 14.5 3.4e-11 43.5 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00946.1 - 9.3e-28 96.4 0.3 1.6e-05 25.1 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCM00946.1 - 1.1e-10 41.7 0.2 8.6e-05 22.5 0.0 3.3 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCM00946.1 - 2.4e-09 36.6 3.1 0.0049 15.9 1.0 3.8 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCM00946.1 - 4.9e-09 35.4 4.8 0.054 12.1 0.1 5.1 1 1 5 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 CCM00946.1 - 4.2e-06 26.3 0.0 0.0018 17.7 0.0 3.1 2 1 1 3 3 3 1 WD40-like domain Nucleoporin_N PF08801.11 CCM00946.1 - 0.0018 17.1 0.4 0.66 8.7 0.1 3.1 2 1 2 4 4 4 1 Nup133 N terminal like PALB2_WD40 PF16756.5 CCM00946.1 - 0.0045 16.0 0.5 0.52 9.2 0.0 3.4 2 1 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain FlgD_ig PF13860.6 CCM00946.1 - 0.012 15.5 0.4 0.41 10.6 0.0 2.7 3 0 0 3 3 3 0 FlgD Ig-like domain DUF5046 PF16465.5 CCM00946.1 - 0.012 15.1 0.0 3 7.2 0.0 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF5046) IKI3 PF04762.12 CCM00946.1 - 0.02 12.9 0.0 0.13 10.2 0.0 2.0 1 1 0 1 1 1 0 IKI3 family Coatomer_WDAD PF04053.14 CCM00946.1 - 0.024 13.7 0.0 0.21 10.6 0.0 2.3 1 1 1 2 2 2 0 Coatomer WD associated region RicinB_lectin_2 PF14200.6 CCM00946.1 - 0.034 14.9 0.1 1.5 9.6 0.0 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.14 CCM00946.1 - 0.055 13.0 0.1 0.28 10.8 0.1 2.0 1 1 1 2 2 2 0 Cytolethal distending toxin A/C domain DUF1513 PF07433.11 CCM00946.1 - 0.064 12.3 0.0 3.5 6.6 0.0 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1513) Frtz PF11768.8 CCM00946.1 - 0.072 11.4 0.0 2 6.6 0.0 2.6 1 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz ubiquitin PF00240.23 CCM00947.1 - 1.5e-170 553.2 25.4 1.9e-33 114.0 0.5 5.0 5 0 0 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 CCM00947.1 - 2.6e-78 257.8 27.8 4.3e-15 55.3 0.6 5.0 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCM00947.1 - 3e-28 98.1 12.9 0.00064 20.1 0.1 6.9 5 5 0 5 5 5 5 Ubiquitin-like domain TBK1_ULD PF18396.1 CCM00947.1 - 1.6e-19 69.6 5.6 0.047 13.6 0.0 5.2 5 0 0 5 5 5 5 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCM00947.1 - 1.2e-17 64.0 4.5 0.16 12.1 0.0 6.0 5 4 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CCM00947.1 - 1.7e-17 63.5 11.5 0.063 13.6 0.1 5.1 5 0 0 5 5 5 5 Ubiquitin-like domain DUF2407 PF10302.9 CCM00947.1 - 5.3e-16 59.1 2.2 0.55 10.8 0.0 5.2 1 1 0 5 5 5 5 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 CCM00947.1 - 3.1e-12 46.6 0.7 1.6 8.5 0.0 5.1 1 1 4 5 5 5 5 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 CCM00947.1 - 3.7e-09 36.3 1.8 1.4 8.2 0.0 4.2 4 0 0 4 4 4 4 RNA methyltransferase Ubiquitin_4 PF18036.1 CCM00947.1 - 1.2e-07 31.7 32.7 21 5.2 0.2 9.9 10 0 0 10 10 10 0 Ubiquitin-like domain Big_7 PF17957.1 CCM00947.1 - 1.6e-07 32.0 0.6 41 5.0 0.0 5.1 5 0 0 5 5 5 0 Bacterial Ig domain DUF2870 PF11069.8 CCM00947.1 - 1.9e-07 31.4 0.0 40 4.7 0.0 5.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2870) TmoB PF06234.12 CCM00947.1 - 4.7e-07 29.8 0.1 40 4.4 0.0 5.8 5 0 0 5 5 5 0 Toluene-4-monooxygenase system protein B (TmoB) DUF3861 PF12977.7 CCM00947.1 - 5.8e-07 29.6 5.6 18 5.6 0.0 5.2 5 0 0 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 CCM00947.1 - 1.2e-06 28.2 6.5 15 5.5 0.0 5.3 5 0 0 5 5 5 0 ACT domain UDP-g_GGTase PF06427.11 CCM00947.1 - 4.3e-06 26.8 6.0 9.6 6.4 0.0 4.9 5 0 0 5 5 5 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 CCM00947.1 - 2.3e-05 23.9 0.1 29 4.0 0.0 4.8 5 0 0 5 5 5 0 Protein of unknown function (DUF969) ACT_4 PF13291.6 CCM00947.1 - 6e-05 23.6 2.2 97 3.7 0.0 5.2 5 0 0 5 5 5 0 ACT domain DUF493 PF04359.14 CCM00947.1 - 0.00037 21.0 0.1 1.9e+02 2.7 0.0 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF493) ORF11CD3 PF10549.9 CCM00947.1 - 0.0007 19.7 0.0 1.2e+02 2.9 0.0 5.1 5 0 0 5 5 5 0 ORF11CD3 domain ProRS-C_2 PF09181.10 CCM00947.1 - 0.008 16.3 8.5 85 3.4 0.1 5.1 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal FlgD_ig PF13860.6 CCM00947.1 - 0.052 13.4 13.5 57 3.7 0.1 5.3 5 0 0 5 5 5 0 FlgD Ig-like domain Tash_PEST PF07708.11 CCM00947.1 - 0.19 11.9 36.0 8 6.8 1.4 5.3 5 0 0 5 5 5 0 Tash protein PEST motif Phage_sheath_1N PF17481.2 CCM00947.1 - 0.46 11.0 12.5 1e+02 3.5 0.1 4.9 1 1 1 3 3 3 0 Phage tail sheath protein beta-sandwich domain YcgR_2 PF12945.7 CCM00947.1 - 2.4 8.4 7.6 3.2e+02 1.6 0.0 4.8 5 0 0 5 5 5 0 Flagellar protein YcgR PI3K_p85B PF02192.16 CCM00947.1 - 3 7.6 12.6 1.3e+02 2.5 0.1 5.1 5 0 0 5 5 5 0 PI3-kinase family, p85-binding domain Cnl2_NKP2 PF09447.10 CCM00947.1 - 3.1 8.0 14.4 1.3e+02 2.8 0.1 5.3 5 0 0 5 5 5 0 Cnl2/NKP2 family protein Ribosomal_S4e PF00900.20 CCM00947.1 - 5.8 6.9 11.7 1.7e+02 2.2 0.1 5.6 5 0 0 5 5 5 0 Ribosomal family S4e Fcf1 PF04900.12 CCM00948.1 - 2.9e-34 117.4 0.4 5.1e-34 116.6 0.4 1.4 1 0 0 1 1 1 1 Fcf1 RepB-RCR_reg PF10723.9 CCM00948.1 - 0.48 10.4 3.3 0.26 11.3 0.7 1.9 2 0 0 2 2 2 0 Replication regulatory protein RepB DUF2012 PF09430.10 CCM00949.1 - 1.1e-18 67.6 0.0 1.7e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) fn3_3 PF14686.6 CCM00949.1 - 0.038 13.8 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 CCM00949.1 - 0.083 13.2 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain CAP PF00188.26 CCM00951.1 - 1.8e-19 70.8 0.9 1.8e-18 67.6 0.6 2.4 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Hamartin PF04388.12 CCM00951.1 - 1.7 7.3 7.7 2 7.0 7.7 1.1 1 0 0 1 1 1 0 Hamartin protein FAD_binding_6 PF00970.24 CCM00952.1 - 1.4e-33 115.1 0.0 3.1e-33 114.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CCM00952.1 - 2.1e-32 112.0 0.0 4.8e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain GST_N_3 PF13417.6 CCM00952.1 - 8.9e-11 42.1 0.0 2e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CCM00952.1 - 5.6e-07 29.8 0.2 2.8e-06 27.6 0.0 2.3 2 1 1 3 3 3 1 Glutathione S-transferase, N-terminal domain NAD_binding_6 PF08030.12 CCM00952.1 - 8.2e-07 29.3 0.0 1.9e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Ferric reductase NAD binding domain GST_N_2 PF13409.6 CCM00952.1 - 8e-06 26.1 0.0 2.2e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM00952.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain FAD_binding_9 PF08021.11 CCM00952.1 - 0.023 14.9 0.0 0.058 13.6 0.0 1.7 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain GST_N_4 PF17172.4 CCM00952.1 - 0.15 12.8 0.0 0.48 11.2 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 CCM00952.1 - 0.18 12.1 0.2 0.73 10.1 0.0 2.1 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein DSPc PF00782.20 CCM00953.1 - 2.5e-11 43.5 0.0 2.8e-08 33.6 0.3 3.8 2 2 0 2 2 2 2 Dual specificity phosphatase, catalytic domain DUF846 PF05832.12 CCM00954.1 - 1e-52 177.9 9.5 1.2e-52 177.6 9.5 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF4191 PF13829.6 CCM00954.1 - 2.6 7.4 4.2 7.8 5.8 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) LRR_4 PF12799.7 CCM00956.1 - 8.6e-12 45.1 14.9 0.052 14.0 0.0 8.2 6 2 1 8 8 8 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCM00956.1 - 2.2e-09 36.6 0.9 9 6.6 0.0 8.9 9 0 0 9 9 9 1 Leucine Rich repeat LRR_8 PF13855.6 CCM00956.1 - 1.4e-06 27.9 8.8 0.37 10.6 0.1 6.7 4 3 1 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 CCM00956.1 - 0.4 11.4 6.7 72 4.5 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat DUF89 PF01937.19 CCM00959.1 - 5.6e-109 364.3 0.0 6.3e-109 364.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Peptidase_M28 PF04389.17 CCM00960.1 - 5.9e-18 65.3 0.0 8e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCM00960.1 - 0.0015 18.3 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Tetraspanin PF00335.20 CCM00963.1 - 0.36 10.5 17.5 1.5 8.5 9.7 2.7 2 1 1 3 3 3 0 Tetraspanin family Amino_oxidase PF01593.24 CCM00964.1 - 7.5e-62 210.1 0.5 3.6e-61 207.8 0.5 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCM00964.1 - 2.2e-09 37.4 0.5 8.2e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCM00964.1 - 0.00029 20.3 0.3 0.00041 19.8 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM00964.1 - 0.00069 18.9 0.4 0.4 9.9 0.5 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM00964.1 - 0.0013 18.4 1.3 0.021 14.4 1.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCM00964.1 - 0.0019 17.5 0.2 0.0033 16.7 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CCM00964.1 - 0.0054 15.9 0.3 0.011 14.8 0.3 1.5 2 0 0 2 2 2 1 FAD binding domain Phosphodiest PF01663.22 CCM00964.1 - 0.01 15.4 0.2 0.017 14.7 0.2 1.4 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Pyr_redox PF00070.27 CCM00964.1 - 0.013 16.1 1.2 0.62 10.7 0.5 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM00964.1 - 0.014 14.6 0.3 0.17 11.1 0.5 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CCM00964.1 - 0.027 13.7 0.1 0.051 12.9 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CCM00964.1 - 0.094 11.9 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Amidohydro_2 PF04909.14 CCM00965.1 - 1.8e-18 67.4 0.0 3.3e-18 66.5 0.0 1.5 2 0 0 2 2 2 1 Amidohydrolase TatD_DNase PF01026.21 CCM00965.1 - 0.00034 20.1 0.0 0.00056 19.4 0.0 1.5 1 0 0 1 1 1 1 TatD related DNase SET PF00856.28 CCM00966.1 - 1e-07 32.5 0.0 3e-07 31.0 0.0 1.7 2 0 0 2 2 2 1 SET domain SUI1 PF01253.22 CCM00967.1 - 2e-20 73.1 0.1 3.7e-20 72.2 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 CCM00967.1 - 6.1e-16 58.9 0.3 2.8e-15 56.8 0.0 2.3 2 1 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 CCM00967.1 - 2.6e-07 30.5 0.1 6e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 PUA domain RepB-RCR_reg PF10723.9 CCM00967.1 - 0.011 15.6 0.3 0.5 10.3 0.0 2.8 2 0 0 2 2 2 0 Replication regulatory protein RepB U1snRNP70_N PF12220.8 CCM00967.1 - 0.053 14.2 0.8 0.14 12.8 0.8 1.8 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Usp PF00582.26 CCM00967.1 - 0.59 10.6 4.2 7.6 7.0 0.5 2.6 2 0 0 2 2 2 0 Universal stress protein family SMP PF04927.12 CCM00969.1 - 0.26 11.8 26.9 0.16 12.5 1.3 4.8 5 0 0 5 5 5 0 Seed maturation protein zf-C2H2 PF00096.26 CCM00970.1 - 0.0022 18.3 0.4 0.0022 18.3 0.4 3.9 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM00970.1 - 0.0034 18.1 0.3 0.0034 18.1 0.3 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger zf-BED PF02892.15 CCM00970.1 - 0.06 13.4 1.6 0.06 13.4 1.6 2.4 3 1 0 3 3 3 0 BED zinc finger zf-C2H2_11 PF16622.5 CCM00970.1 - 0.1 12.4 0.5 0.1 12.4 0.5 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type RrnaAD PF00398.20 CCM00971.1 - 1.8e-63 214.1 0.0 2.4e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CCM00971.1 - 3.3e-07 30.9 0.0 7.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCM00971.1 - 3.7e-05 23.3 0.0 8.9e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CCM00971.1 - 5.3e-05 23.8 0.0 0.00012 22.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCM00971.1 - 0.00014 21.7 0.0 0.00025 20.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 CCM00971.1 - 0.00071 19.4 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM00971.1 - 0.0015 19.2 0.0 0.0029 18.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCM00971.1 - 0.0016 17.8 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 CCM00971.1 - 0.0056 16.0 0.0 0.012 14.9 0.0 1.5 2 0 0 2 2 2 1 O-methyltransferase domain DREV PF05219.12 CCM00971.1 - 0.025 13.7 0.1 0.051 12.7 0.0 1.5 2 0 0 2 2 2 0 DREV methyltransferase Methyltransf_31 PF13847.6 CCM00971.1 - 0.036 13.9 0.0 0.078 12.8 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_28 PF02636.17 CCM00971.1 - 0.038 13.6 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 CCM00971.1 - 0.052 12.9 0.0 0.091 12.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family NodS PF05401.11 CCM00971.1 - 0.072 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Cons_hypoth95 PF03602.15 CCM00971.1 - 0.078 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 BolA PF01722.18 CCM00972.1 - 1.6e-11 44.3 0.3 1.1e-05 25.7 0.0 2.5 2 1 0 2 2 2 2 BolA-like protein BTB PF00651.31 CCM00973.1 - 3.2e-07 30.6 0.0 5.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain MIP PF00230.20 CCM00974.1 - 2.2e-28 99.5 5.9 3.2e-28 99.0 5.9 1.1 1 0 0 1 1 1 1 Major intrinsic protein F-box-like PF12937.7 CCM00975.1 - 0.015 15.2 0.1 0.085 12.8 0.1 2.3 1 1 0 1 1 1 0 F-box-like ORF_2_N PF18492.1 CCM00975.1 - 0.026 14.7 0.0 0.046 13.9 0.0 1.3 1 0 0 1 1 1 0 Open reading frame 2 N-terminal domain Kelch_4 PF13418.6 CCM00976.1 - 2.7e-39 132.9 8.2 1.7e-06 27.9 0.6 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 CCM00976.1 - 3.9e-33 112.9 11.3 1.1e-09 38.1 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 CCM00976.1 - 5e-32 109.5 15.8 7e-07 29.4 0.0 7.0 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_1 PF01344.25 CCM00976.1 - 1.5e-28 98.1 11.3 5.7e-07 29.0 0.8 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 CCM00976.1 - 1e-23 82.7 11.9 0.00081 19.6 0.0 6.4 3 2 3 6 6 6 5 Kelch motif Kelch_2 PF07646.15 CCM00976.1 - 1.9e-17 62.5 13.5 1.8e-05 24.5 0.5 6.3 6 0 0 6 6 6 4 Kelch motif PRP38_assoc PF12871.7 CCM00976.1 - 0.0063 17.1 19.8 0.011 16.3 19.8 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Herpes_DNAp_acc PF04929.12 CCM00976.1 - 5.9 5.7 10.7 8.8 5.2 10.7 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor MFS_1 PF07690.16 CCM00979.1 - 1.2e-21 77.0 27.8 2.5e-21 76.0 27.8 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCM00980.1 - 5.7e-11 41.9 29.0 5.7e-11 41.9 29.0 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily p450 PF00067.22 CCM00981.1 - 6.1e-72 242.8 0.0 1.1e-71 242.0 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 APOBEC_C PF05240.14 CCM00981.1 - 0.17 11.8 0.1 0.39 10.7 0.1 1.6 1 0 0 1 1 1 0 APOBEC-like C-terminal domain HSP20 PF00011.21 CCM00982.1 - 7.1e-22 77.5 0.0 1e-21 77.0 0.0 1.3 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCM00982.1 - 9.7e-10 37.9 0.0 1.5e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA BON PF04972.17 CCM00982.1 - 0.0069 16.7 0.4 0.051 13.9 0.4 2.0 2 0 0 2 2 2 1 BON domain HMA PF00403.26 CCM00982.1 - 0.071 13.6 0.4 0.48 10.9 0.2 2.0 2 0 0 2 2 2 0 Heavy-metal-associated domain Rtt106 PF08512.12 CCM00983.1 - 2.7e-18 66.2 0.0 5.1e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_18 PF18469.1 CCM00983.1 - 0.00079 19.4 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain WD40 PF00400.32 CCM00984.1 - 3.2e-41 138.5 4.1 2e-07 31.6 0.1 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM00984.1 - 8.2e-18 64.5 0.0 0.26 11.6 0.0 7.1 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM00984.1 - 4.8e-08 32.3 0.8 0.45 9.4 0.0 5.0 2 2 2 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CCM00984.1 - 3.3e-05 23.7 2.1 0.55 10.2 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 CCM00984.1 - 0.011 15.1 0.1 1.8 7.8 0.0 3.5 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Gmad1 PF10647.9 CCM00984.1 - 0.039 13.7 0.5 5.8 6.6 0.0 3.5 4 1 1 5 5 5 0 Lipoprotein LpqB beta-propeller domain Bac_rhamnosid6H PF17389.2 CCM00985.1 - 2.1e-17 63.4 0.1 3.2e-17 62.8 0.1 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 CCM00985.1 - 3.9e-07 29.8 0.0 3.1e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain MMR_HSR1 PF01926.23 CCM00986.1 - 7.1e-05 22.9 0.0 0.00022 21.3 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM00986.1 - 0.0073 16.2 0.2 0.099 12.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase DUF3399 PF11879.8 CCM00986.1 - 0.0083 16.4 0.5 0.021 15.1 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3399) AAA_16 PF13191.6 CCM00986.1 - 0.031 14.7 0.1 0.19 12.1 0.3 2.3 2 1 0 2 2 2 0 AAA ATPase domain E1-N PF14463.6 CCM00986.1 - 0.045 13.6 0.6 0.081 12.7 0.6 1.3 1 0 0 1 1 1 0 E1 N-terminal domain G-alpha PF00503.20 CCM00986.1 - 0.08 12.1 0.1 0.66 9.1 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit DUF815 PF05673.13 CCM00986.1 - 0.12 11.6 0.0 0.27 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Roc PF08477.13 CCM00986.1 - 0.15 12.3 0.1 0.69 10.1 0.1 2.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 CCM00986.1 - 0.2 12.2 1.0 1.9 9.0 1.0 2.4 1 1 0 1 1 1 0 AAA domain p450 PF00067.22 CCM00987.1 - 2.9e-58 197.7 0.0 4e-54 184.1 0.0 2.6 2 1 0 2 2 2 2 Cytochrome P450 Siva PF05458.12 CCM00987.1 - 0.031 13.9 0.0 0.053 13.2 0.0 1.2 1 0 0 1 1 1 0 Cd27 binding protein (Siva) GTP_cyclohydroI PF01227.22 CCM00987.1 - 0.17 11.3 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase I DUF4205 PF13898.6 CCM00987.1 - 0.23 10.3 0.2 0.36 9.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) p450 PF00067.22 CCM00988.1 - 1.4e-62 212.0 0.0 5.5e-62 210.0 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCM00988.1 - 0.1 11.5 0.3 0.16 10.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) Siva PF05458.12 CCM00988.1 - 0.14 11.9 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 Cd27 binding protein (Siva) SWI-SNF_Ssr4 PF08549.10 CCM00989.1 - 2.1e-25 89.5 2.0 2.1e-25 89.5 2.0 1.7 2 1 0 2 2 2 1 Fungal domain of unknown function (DUF1750) CG-1 PF03859.16 CCM00989.1 - 0.16 11.8 0.0 0.71 9.7 0.0 2.0 1 1 0 1 1 1 0 CG-1 domain TRAF_BIRC3_bd PF16673.5 CCM00989.1 - 0.26 11.1 5.4 0.23 11.3 0.5 2.5 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF1518 PF07469.12 CCM00989.1 - 0.93 9.9 7.4 0.28 11.6 3.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1518) Pyr_redox_2 PF07992.14 CCM00990.1 - 5.8e-31 107.8 0.6 8.2e-31 107.3 0.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM00990.1 - 3.6e-15 56.3 2.3 1.6e-11 44.6 0.1 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM00990.1 - 1.1e-06 28.5 10.0 0.23 11.0 0.5 4.2 2 2 1 4 4 4 3 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCM00990.1 - 1.7e-06 28.1 4.9 0.019 15.0 0.1 3.8 4 1 1 5 5 5 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CCM00990.1 - 5.4e-06 25.9 0.0 1.7e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM00990.1 - 2.1e-05 23.9 0.1 0.04 13.1 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 CCM00990.1 - 0.00017 22.0 0.5 0.56 10.7 0.0 3.3 3 0 0 3 3 3 1 Putative NAD(P)-binding Trp_halogenase PF04820.14 CCM00990.1 - 0.00023 20.1 0.9 0.042 12.7 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.12 CCM00990.1 - 0.0004 19.6 0.0 1.1 8.2 0.0 3.0 3 0 0 3 3 3 2 Lycopene cyclase protein GIDA PF01134.22 CCM00990.1 - 0.00067 18.8 1.3 9 5.3 0.2 3.9 4 0 0 4 4 4 1 Glucose inhibited division protein A TrkA_N PF02254.18 CCM00990.1 - 0.0063 16.8 0.2 0.43 10.9 0.1 2.4 2 0 0 2 2 2 1 TrkA-N domain DUF4147 PF13660.6 CCM00990.1 - 0.022 14.3 0.0 4.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4147) NAD_binding_8 PF13450.6 CCM00990.1 - 0.07 13.4 0.7 1.6 9.0 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCM00990.1 - 0.074 12.3 0.3 4.6 6.4 0.1 2.2 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 CCM00990.1 - 0.092 11.8 2.3 6.7 5.7 0.0 2.5 1 1 0 2 2 2 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 CCM00990.1 - 0.11 12.7 0.6 5.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Aldo_ket_red PF00248.21 CCM00991.1 - 6.3e-48 163.5 0.0 4.8e-47 160.6 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Homeodomain PF00046.29 CCM00991.1 - 0.068 13.0 0.1 1.5 8.8 0.1 2.4 2 0 0 2 2 2 0 Homeodomain HTH_Tnp_ISL3 PF13542.6 CCM00991.1 - 0.12 11.8 0.3 18 4.8 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HIT PF01230.23 CCM00992.1 - 1.5e-24 86.6 0.3 2e-24 86.2 0.3 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CCM00992.1 - 1.4e-12 48.1 0.2 1.9e-12 47.7 0.2 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 CCM00992.1 - 7.1e-07 29.1 0.1 1e-06 28.6 0.1 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Q_salvage PF10343.9 CCM00992.1 - 0.17 11.4 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family Herpes_US9 PF06072.11 CCM00993.1 - 0.036 13.9 0.2 0.076 12.9 0.2 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 p450 PF00067.22 CCM00994.1 - 6.8e-51 173.4 0.0 2e-50 171.9 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 SAM_2 PF07647.17 CCM00995.1 - 7.7e-09 35.5 0.0 2.7e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CCM00995.1 - 2.5e-06 27.9 0.0 5.3e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 CCM00995.1 - 0.094 13.0 0.7 0.18 12.1 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4508) GSH_synth_ATP PF03917.17 CCM00996.1 - 5e-127 423.7 0.0 5.8e-127 423.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CCM00996.1 - 1e-33 115.9 0.0 1.5e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Dynamin_N PF00350.23 CCM00997.1 - 7.6e-20 71.6 0.2 1.9e-19 70.3 0.2 1.7 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CCM00997.1 - 3.1e-13 49.8 0.1 6.4e-12 45.6 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCM00997.1 - 2.9e-08 33.5 0.6 1.8e-05 24.3 0.0 3.0 3 1 0 3 3 3 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM00997.1 - 0.00013 21.9 1.3 0.23 11.4 0.4 2.7 2 1 0 2 2 2 2 RsgA GTPase cobW PF02492.19 CCM00997.1 - 0.0025 17.4 0.1 0.27 10.8 0.2 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 CCM00997.1 - 0.007 15.5 0.1 0.013 14.6 0.1 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Roc PF08477.13 CCM00997.1 - 0.013 15.7 0.3 1.7 8.9 0.0 3.3 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 CCM00997.1 - 0.02 14.9 0.0 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 CCM00997.1 - 0.043 13.6 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM00997.1 - 0.11 12.9 0.8 0.75 10.1 0.0 2.8 2 1 1 3 3 3 0 AAA ATPase domain DUF3883 PF13020.6 CCM00997.1 - 0.19 11.8 0.6 1.4 9.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3883) Glyco_hydro_16 PF00722.21 CCM00998.1 - 2.5e-05 23.8 0.1 4.1e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 adh_short PF00106.25 CCM00999.1 - 1.5e-31 109.4 0.1 2.8e-31 108.5 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM00999.1 - 1.5e-29 103.3 0.4 9.6e-29 100.6 0.4 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM00999.1 - 9.4e-08 32.2 0.5 2e-07 31.1 0.5 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCM00999.1 - 0.0034 16.8 0.1 0.0052 16.2 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCM00999.1 - 0.0063 16.0 0.2 0.0096 15.4 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family SYS1 PF09801.9 CCM00999.1 - 0.043 14.0 0.0 0.082 13.1 0.0 1.4 1 0 0 1 1 1 0 Integral membrane protein S linking to the trans Golgi network TrkA_N PF02254.18 CCM00999.1 - 0.066 13.5 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain p450 PF00067.22 CCM01000.1 - 3.9e-61 207.2 0.0 8.5e-45 153.4 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Reticulon PF02453.17 CCM01000.1 - 0.047 13.6 0.2 0.047 13.6 0.2 1.6 2 0 0 2 2 2 0 Reticulon p450 PF00067.22 CCM01001.1 - 1.7e-64 218.3 0.0 3.9e-64 217.1 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCM01001.1 - 0.048 12.6 0.1 0.077 11.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) p450 PF00067.22 CCM01002.1 - 2.4e-62 211.2 0.0 6.8e-62 209.7 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCM01002.1 - 0.013 14.5 0.0 0.018 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) p450 PF00067.22 CCM01003.1 - 1e-61 209.2 0.0 4.3e-61 207.1 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 Siva PF05458.12 CCM01003.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Cd27 binding protein (Siva) p450 PF00067.22 CCM01004.1 - 4.8e-120 401.4 0.0 1.3e-60 205.5 0.0 3.1 1 1 1 2 2 2 2 Cytochrome P450 DUF4205 PF13898.6 CCM01004.1 - 0.00019 20.5 2.5 0.049 12.6 0.3 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4205) GTP_cyclohydroI PF01227.22 CCM01004.1 - 0.025 14.0 0.0 7.9 5.9 0.0 2.3 2 0 0 2 2 2 0 GTP cyclohydrolase I Siva PF05458.12 CCM01004.1 - 0.064 12.9 0.3 5.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Cd27 binding protein (Siva) FIBP PF05427.11 CCM01004.1 - 0.085 12.1 0.0 7.5 5.7 0.0 2.2 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) ZirS_C PF16583.5 CCM01004.1 - 0.097 12.2 0.0 20 4.8 0.0 2.8 2 0 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain MRP PF09387.10 CCM01004.1 - 0.16 12.0 0.0 29 4.6 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial RNA binding protein MRP p450 PF00067.22 CCM01005.1 - 4.3e-60 203.8 0.0 1.4e-59 202.1 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCM01005.1 - 0.19 10.6 0.1 0.29 10.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) Siva PF05458.12 CCM01005.1 - 0.21 11.2 0.0 0.37 10.5 0.0 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) adh_short_C2 PF13561.6 CCM01006.1 - 5.5e-29 101.4 1.1 1e-27 97.2 1.1 2.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM01006.1 - 9.1e-27 93.8 0.9 1.4e-25 90.0 0.9 2.2 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM01006.1 - 0.0033 17.4 2.8 0.2 11.6 2.8 2.5 1 1 0 1 1 1 1 KR domain MMR_HSR1 PF01926.23 CCM01007.1 - 9.4e-06 25.7 0.0 2.1e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCM01007.1 - 0.0016 18.8 0.1 0.0066 16.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCM01007.1 - 0.0035 17.3 0.0 0.027 14.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Roc PF08477.13 CCM01007.1 - 0.023 14.9 0.1 0.45 10.7 0.0 2.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 CCM01007.1 - 0.058 12.6 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_21 PF13304.6 CCM01007.1 - 0.091 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CCM01007.1 - 0.15 12.4 0.0 0.43 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sel1 PF08238.12 CCM01008.1 - 1.1e-24 86.3 34.7 2.2e-05 25.0 0.7 10.1 9 2 0 9 9 8 6 Sel1 repeat TPR_16 PF13432.6 CCM01008.1 - 1e-06 29.3 0.6 0.00055 20.5 0.1 5.9 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01008.1 - 0.0002 21.3 0.6 0.0044 17.1 0.1 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM01008.1 - 0.0013 19.0 0.8 0.027 14.7 0.1 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCM01008.1 - 0.0016 18.3 0.1 0.046 13.6 0.0 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM01008.1 - 0.0019 18.2 0.1 0.0019 18.2 0.1 6.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCM01008.1 - 0.002 17.8 0.1 0.002 17.8 0.1 4.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCM01008.1 - 0.0096 15.9 6.3 1.7 8.8 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat DUF2615 PF11027.8 CCM01008.1 - 0.036 14.2 0.0 0.085 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) ANAPC3 PF12895.7 CCM01008.1 - 0.083 13.1 1.0 0.51 10.6 0.5 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCM01008.1 - 0.12 12.9 2.8 0.25 11.9 0.6 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat HemY_N PF07219.13 CCM01008.1 - 0.3 11.3 2.1 6.6 7.0 0.1 2.9 2 0 0 2 2 2 0 HemY protein N-terminus TPR_6 PF13174.6 CCM01008.1 - 0.39 11.5 14.9 0.55 11.0 0.1 6.8 9 0 0 9 9 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCM01008.1 - 0.54 11.2 0.0 0.54 11.2 0.0 5.9 7 1 1 8 8 4 0 Tetratricopeptide repeat SUIM_assoc PF16619.5 CCM01008.1 - 3.2 7.9 6.1 1.5 9.0 2.8 2.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TPR_11 PF13414.6 CCM01008.1 - 5.4 6.8 6.2 3.6 7.3 0.1 3.5 2 1 1 3 3 3 0 TPR repeat Efg1 PF10153.9 CCM01009.1 - 3.6e-37 127.2 12.3 7.2e-37 126.2 12.3 1.5 1 0 0 1 1 1 1 rRNA-processing protein Efg1 Fez1 PF06818.15 CCM01009.1 - 0.0057 17.1 7.0 0.0057 17.1 7.0 1.8 2 0 0 2 2 2 1 Fez1 Spc7 PF08317.11 CCM01009.1 - 6.6 5.5 13.1 27 3.5 13.1 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein Bromodomain PF00439.25 CCM01012.1 - 1e-20 73.6 0.6 2.9e-20 72.1 0.4 1.9 1 1 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 CCM01012.1 - 3.1e-06 27.1 0.0 6.9e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated WD40 PF00400.32 CCM01013.1 - 2.1e-18 66.3 11.5 0.0006 20.6 0.0 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM01013.1 - 1.5e-14 54.1 1.0 6.4e-06 26.4 0.2 4.2 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCM01013.1 - 0.0029 17.5 0.1 0.45 10.4 0.1 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 CCM01013.1 - 0.037 13.3 0.0 0.38 10.0 0.0 2.1 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal FAD_binding_4 PF01565.23 CCM01014.1 - 1e-09 38.3 0.1 0.00051 19.8 0.0 3.2 2 1 0 2 2 2 2 FAD binding domain BBE PF08031.12 CCM01014.1 - 2.5e-05 24.3 0.2 4.9e-05 23.3 0.2 1.4 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 CCM01014.1 - 0.019 14.4 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding RhoGEF PF00621.20 CCM01015.1 - 2e-32 112.9 0.0 3.3e-32 112.2 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain SelP_N PF04592.14 CCM01015.1 - 1.1 8.5 7.3 2 7.8 7.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region E1-E2_ATPase PF00122.20 CCM01016.1 - 6.1e-49 166.0 1.5 5e-48 163.0 0.1 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCM01016.1 - 2.5e-36 125.1 2.2 2.5e-36 125.1 2.2 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CCM01016.1 - 2.3e-21 77.1 0.3 6.8e-21 75.5 0.3 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCM01016.1 - 8.6e-13 48.2 0.0 5.6e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCM01016.1 - 2.7e-10 39.8 0.0 6.2e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCM01016.1 - 2.4e-05 24.2 2.3 0.0015 18.4 1.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RseC_MucC PF04246.12 CCM01016.1 - 0.011 15.7 2.4 0.012 15.5 0.0 2.3 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC CoA_transf_3 PF02515.17 CCM01017.1 - 7.7e-101 337.9 0.0 9.5e-101 337.6 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III Lactonase PF10282.9 CCM01018.1 - 1.3e-53 182.5 0.0 1.4e-53 182.4 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Aldo_ket_red PF00248.21 CCM01021.1 - 2.7e-47 161.4 0.0 1.1e-46 159.4 0.0 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family Shikimate_DH PF01488.20 CCM01021.1 - 0.17 11.9 0.2 0.61 10.1 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase EF-hand_1 PF00036.32 CCM01023.1 - 7.7e-22 75.2 1.1 1.7e-05 24.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CCM01023.1 - 3.1e-21 73.5 0.7 4.9e-06 26.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 CCM01023.1 - 2.4e-17 63.1 0.2 1.9e-07 31.4 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCM01023.1 - 3.3e-17 61.1 0.9 0.00012 21.4 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CCM01023.1 - 1.2e-11 44.3 4.4 3.3e-06 26.9 0.1 4.5 3 2 1 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 CCM01023.1 - 0.02 15.2 0.1 16 5.9 0.0 3.0 3 1 0 3 3 3 0 EF-hand domain Peptidase_M22 PF00814.25 CCM01024.1 - 0.00019 21.2 0.0 0.00028 20.7 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family SOGA PF11365.8 CCM01025.1 - 0.28 12.3 16.2 1.5 10.0 4.1 3.3 2 1 1 3 3 3 0 Protein SOGA Pilus_CpaD PF09476.10 CCM01025.1 - 0.64 9.7 6.7 1.4 8.6 6.7 1.6 1 1 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) Aldo_ket_red PF00248.21 CCM01026.1 - 4.1e-74 249.4 0.0 4.6e-74 249.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family KHA PF11834.8 CCM01027.1 - 0.025 14.7 0.0 0.061 13.4 0.0 1.6 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel TUG-UBL1 PF11470.8 CCM01027.1 - 0.12 12.7 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 TUG ubiquitin-like domain Asp PF00026.23 CCM01028.1 - 6.8e-25 88.1 10.6 1.1e-23 84.2 10.6 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM01028.1 - 6.7e-09 36.2 3.7 1.1e-05 25.8 0.1 2.7 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Peptidase_M24 PF00557.24 CCM01030.1 - 9.5e-58 195.3 0.3 1.3e-57 194.9 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CCM01030.1 - 5e-37 126.4 0.0 9.9e-37 125.4 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain AA_permease_2 PF13520.6 CCM01031.1 - 3.2e-45 154.7 49.5 4.1e-45 154.4 49.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCM01031.1 - 7e-19 67.8 38.5 9.5e-19 67.3 38.5 1.1 1 0 0 1 1 1 1 Amino acid permease Phage_holin_3_6 PF07332.11 CCM01031.1 - 0.23 11.5 0.1 0.23 11.5 0.1 4.4 3 1 1 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III GTP_EFTU PF00009.27 CCM01032.1 - 3.3e-34 118.1 0.0 2.7e-33 115.1 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CCM01032.1 - 2.1e-19 69.6 0.0 5.3e-19 68.3 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 CCM01032.1 - 1.1e-12 48.1 8.9 3.6e-09 36.9 0.1 3.4 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCM01032.1 - 6.3e-07 29.5 0.7 7e-06 26.1 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CCM01032.1 - 6.7e-06 25.9 0.1 2e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Roc PF08477.13 CCM01032.1 - 0.00029 21.0 0.0 0.00079 19.6 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CCM01032.1 - 0.00079 19.3 0.0 0.0037 17.1 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Ras PF00071.22 CCM01032.1 - 0.058 13.0 0.0 0.23 11.0 0.0 2.1 1 1 0 1 1 1 0 Ras family AAA_22 PF13401.6 CCM01032.1 - 0.071 13.4 0.2 0.87 9.9 0.2 2.6 1 1 0 1 1 1 0 AAA domain Arf PF00025.21 CCM01033.1 - 1.4e-70 236.3 0.1 1.6e-70 236.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCM01033.1 - 8.8e-13 48.1 1.1 6.4e-07 28.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CCM01033.1 - 6.9e-10 39.2 0.0 1.1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CCM01033.1 - 2.1e-09 37.1 0.0 2.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CCM01033.1 - 2.3e-09 37.0 0.0 3.2e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 CCM01033.1 - 7e-07 29.0 0.0 9e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CCM01033.1 - 9.5e-06 25.7 0.0 1.9e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CCM01033.1 - 0.056 13.2 0.0 0.099 12.4 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 CCM01033.1 - 0.1 13.1 0.0 0.18 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain Asp PF00026.23 CCM01034.1 - 1.3e-38 133.3 0.1 2.7e-37 128.9 0.1 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM01034.1 - 9.2e-05 22.7 0.2 0.044 14.0 0.0 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal PCRF PF03462.18 CCM01035.1 - 7.8e-50 169.4 0.2 1.7e-49 168.3 0.0 1.6 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CCM01035.1 - 1.1e-32 112.3 1.4 2.9e-32 111.0 1.4 1.6 1 0 0 1 1 1 1 RF-1 domain SIR4_SID PF16991.5 CCM01035.1 - 0.28 11.2 1.2 0.46 10.5 0.2 1.9 2 1 0 2 2 2 0 Sir4 SID domain Mito_carr PF00153.27 CCM01036.1 - 6e-43 144.7 1.2 1.6e-17 63.2 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3506 PF12014.8 CCM01036.1 - 0.18 11.8 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3506) Acyl-CoA_dh_1 PF00441.24 CCM01037.1 - 8.8e-44 149.3 2.9 8.8e-44 149.3 2.9 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCM01037.1 - 1e-29 103.5 1.6 2.5e-29 102.2 0.1 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CCM01037.1 - 4.4e-22 78.1 0.0 8.1e-22 77.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCM01037.1 - 2.1e-20 73.3 1.1 2.1e-20 73.3 1.1 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 CCM01037.1 - 0.0073 16.9 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal DUF2433 PF10360.9 CCM01038.1 - 1.9e-45 153.9 0.0 3.5e-45 153.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) RRM_1 PF00076.22 CCM01038.1 - 0.0017 18.1 0.0 0.0036 17.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos PF00149.28 CCM01038.1 - 0.13 12.7 0.0 0.34 11.4 0.0 1.5 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase MAP65_ASE1 PF03999.12 CCM01038.1 - 0.68 8.6 2.9 1 8.0 2.9 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Rrn6 PF10214.9 CCM01038.1 - 2.2 6.7 7.5 3.2 6.1 7.5 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Med13_C PF06333.12 CCM01039.1 - 9.2e-44 150.0 5.3 9.2e-44 150.0 5.3 4.0 2 2 0 2 2 2 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 CCM01039.1 - 1.1e-37 130.1 0.6 2e-37 129.2 0.6 1.4 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal Haem_degrading PF03928.14 CCM01040.1 - 6.7e-36 123.0 0.1 8e-36 122.7 0.1 1.1 1 0 0 1 1 1 1 Haem-degrading BolA PF01722.18 CCM01041.1 - 5.3e-15 55.5 0.0 1.4e-14 54.1 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein COX15-CtaA PF02628.15 CCM01042.1 - 1.3e-109 366.2 8.7 1.6e-109 365.9 8.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Proteasome PF00227.26 CCM01043.1 - 3.6e-52 176.6 0.0 4.8e-52 176.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCM01043.1 - 2.8e-10 39.7 1.8 3.9e-10 39.2 0.1 2.1 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Alk_phosphatase PF00245.20 CCM01046.1 - 0.16 10.9 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Alkaline phosphatase F-box-like PF12937.7 CCM01048.1 - 0.038 13.9 0.1 0.42 10.5 0.0 2.4 2 0 0 2 2 2 0 F-box-like F-box PF00646.33 CCM01048.1 - 0.12 12.3 1.3 47 4.0 0.5 3.4 3 0 0 3 3 3 0 F-box domain IQ PF00612.27 CCM01048.1 - 0.63 10.0 2.4 1.3 9.0 2.4 1.5 1 0 0 1 1 1 0 IQ calmodulin-binding motif Abhydrolase_3 PF07859.13 CCM01049.1 - 2.4e-20 73.3 0.0 3.2e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCM01049.1 - 8.8e-09 34.7 0.0 3.2e-08 32.8 0.0 1.7 2 0 0 2 2 2 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 CCM01049.1 - 0.0027 18.3 0.2 0.0027 18.3 0.2 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF2974 PF11187.8 CCM01049.1 - 0.09 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PIG-P PF08510.12 CCM01049.1 - 0.36 10.8 1.3 0.66 9.9 1.3 1.3 1 0 0 1 1 1 0 PIG-P Catalase PF00199.19 CCM01050.1 - 2.7e-188 625.9 0.0 3.3e-188 625.6 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CCM01050.1 - 8.8e-16 57.9 0.0 2.3e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 Catalase-related immune-responsive Ribosomal_L14 PF00238.19 CCM01051.1 - 1.8e-29 102.3 0.0 2.4e-25 89.0 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein L14p/L23e RRM_1 PF00076.22 CCM01052.1 - 9e-12 44.6 0.1 3e-10 39.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sugarporin_N PF11471.8 CCM01052.1 - 0.064 13.2 0.7 0.14 12.1 0.7 1.5 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension RL PF17797.1 CCM01052.1 - 0.08 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 RL domain zf-C2H2_4 PF13894.6 CCM01053.1 - 2.8e-06 27.7 4.8 0.013 16.2 0.4 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCM01053.1 - 1.3e-05 25.4 5.5 0.024 15.1 0.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-ribbon_3 PF13248.6 CCM01053.1 - 0.0041 16.5 2.4 0.37 10.3 0.2 2.9 3 0 0 3 3 3 2 zinc-ribbon domain zinc_ribbon_4 PF13717.6 CCM01053.1 - 0.036 14.0 1.6 9.4 6.3 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-Di19 PF05605.12 CCM01053.1 - 0.11 12.8 3.7 1.1 9.6 0.3 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 CCM01053.1 - 0.18 12.1 3.9 8.5 6.7 0.8 2.7 2 0 0 2 2 2 0 zinc-ribbon Zn-ribbon_8 PF09723.10 CCM01053.1 - 0.32 11.2 4.5 1.2 9.4 0.4 2.5 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 CCM01053.1 - 3.9 7.6 6.5 19 5.4 6.5 2.1 1 1 0 1 1 1 0 Double zinc ribbon Zn_ribbon_SprT PF17283.2 CCM01053.1 - 5.1 7.1 6.1 56 3.8 6.2 2.5 1 1 0 1 1 1 0 SprT-like zinc ribbon domain HAD_2 PF13419.6 CCM01054.1 - 2.4e-07 31.0 0.0 4.2e-07 30.2 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCM01054.1 - 0.08 13.2 0.1 0.37 11.0 0.0 2.2 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM01054.1 - 0.1 12.7 0.0 0.23 11.5 0.0 1.7 1 1 0 1 1 1 0 HAD-hyrolase-like Acetyltransf_3 PF13302.7 CCM01055.1 - 3.1e-05 24.7 0.2 6.4e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM01055.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family PRNT PF15174.6 CCM01056.1 - 0.018 15.1 0.1 0.039 14.0 0.1 1.5 1 0 0 1 1 1 0 Prion-related protein testis-specific Cupin_5 PF06172.11 CCM01057.1 - 1.8e-42 144.8 0.0 2.2e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) ADH_N_2 PF16884.5 CCM01058.1 - 2.8e-17 62.6 0.0 6.5e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CCM01058.1 - 7.8e-15 55.0 0.0 2.6e-14 53.3 0.0 1.9 1 1 1 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 CCM01058.1 - 0.00038 20.3 0.2 0.0013 18.5 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2855) ADH_N_2 PF16884.5 CCM01059.1 - 1.1e-19 70.4 0.0 2.7e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CCM01059.1 - 1.2e-18 67.4 0.5 9.4e-18 64.4 0.0 2.4 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM01059.1 - 2.6e-06 28.5 0.0 1.4e-05 26.1 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 CCM01059.1 - 7.4e-06 25.9 0.1 0.00024 21.0 0.0 2.1 1 1 0 2 2 2 1 Protein of unknown function (DUF2855) TrkA_N PF02254.18 CCM01059.1 - 0.0026 18.0 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain FlaA PF04620.12 CCM01059.1 - 0.014 15.1 0.1 0.032 13.9 0.0 1.6 2 0 0 2 2 2 0 Flagellar filament outer layer protein Flaa ADH_N PF08240.12 CCM01060.1 - 3.2e-27 94.6 1.7 4.1e-27 94.2 0.6 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM01060.1 - 1.4e-19 70.4 0.8 2.4e-19 69.6 0.2 1.8 2 1 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCM01060.1 - 5.7e-07 29.2 1.6 9.7e-07 28.5 1.6 1.3 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus TrkA_N PF02254.18 CCM01060.1 - 0.00035 20.8 0.1 0.0007 19.8 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 CCM01060.1 - 0.00049 19.5 0.4 0.00085 18.7 0.4 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CCM01060.1 - 0.00051 21.1 0.1 0.001 20.1 0.1 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 CCM01060.1 - 0.019 14.9 0.2 0.036 14.0 0.2 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated Pyr_redox_3 PF13738.6 CCM01060.1 - 0.072 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCM01060.1 - 0.12 11.6 0.2 0.17 11.1 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain ADH_N PF08240.12 CCM01061.1 - 1.3e-28 99.0 3.2 2.6e-28 98.0 3.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM01061.1 - 1.8e-19 70.0 0.1 3.3e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCM01061.1 - 3.6e-05 23.4 0.9 6.6e-05 22.5 0.9 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCM01061.1 - 6e-05 24.1 0.0 0.00016 22.7 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM01062.1 - 2.7e-29 101.2 3.7 3.6e-29 100.8 2.8 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM01062.1 - 6.1e-20 71.5 1.2 1.3e-19 70.5 0.2 2.0 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM01062.1 - 6.9e-05 23.9 0.0 0.00015 22.8 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCM01062.1 - 0.00022 20.8 2.4 0.0004 19.9 2.4 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CCM01062.1 - 0.00027 20.3 0.5 0.00027 20.3 0.5 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CCM01062.1 - 0.021 15.1 0.1 0.045 14.0 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain ADH_N_assoc PF13823.6 CCM01062.1 - 0.071 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated HET PF06985.11 CCM01063.1 - 1.9e-10 41.3 5.3 2e-08 34.7 0.5 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) F-box-like PF12937.7 CCM01064.1 - 0.00056 19.8 9.0 0.42 10.6 0.2 3.6 3 0 0 3 3 3 2 F-box-like tRNA_anti_2 PF13742.6 CCM01064.1 - 0.072 13.3 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF3322 PF11795.8 CCM01064.1 - 1 9.3 6.7 1.3 9.0 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) F-box-like PF12937.7 CCM01065.1 - 0.012 15.4 0.9 0.044 13.7 0.9 2.0 1 0 0 1 1 1 0 F-box-like Nod1 PF17114.5 CCM01070.1 - 0.0037 17.4 0.1 0.0095 16.1 0.1 1.7 1 0 0 1 1 1 1 Gef2-related medial cortical node protein Nod1 CDRN PF05174.12 CCM01073.1 - 0.11 12.2 0.0 0.36 10.6 0.0 1.9 1 0 0 1 1 1 0 Cysteine-rich D. radiodurans N terminus F-box-like PF12937.7 CCM01074.1 - 4.1e-08 33.0 0.0 8.7e-08 31.9 0.0 1.6 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01074.1 - 0.0069 16.2 0.9 0.85 9.6 0.2 2.4 2 0 0 2 2 2 2 F-box domain F-box-like PF12937.7 CCM01075.1 - 5.8e-10 38.9 1.6 1.9e-09 37.2 1.6 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01075.1 - 0.04 13.8 5.5 2.1 8.3 0.4 3.0 2 0 0 2 2 2 0 F-box domain zf-C2H2 PF00096.26 CCM01076.1 - 0.0075 16.7 0.1 1.8 9.2 0.0 2.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM01076.1 - 0.0099 16.6 0.2 5.2 8.2 0.0 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger PIG-X PF08320.12 CCM01076.1 - 0.092 12.6 0.1 0.24 11.3 0.0 1.6 1 1 1 2 2 2 0 PIG-X / PBN1 F-box-like PF12937.7 CCM01077.1 - 5.9e-06 26.1 0.0 1.6e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 F-box-like zf-C2H2 PF00096.26 CCM01078.1 - 3.5e-07 30.3 0.5 0.00085 19.7 0.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM01078.1 - 0.0071 17.1 0.7 6.9 7.8 0.0 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCM01078.1 - 0.0077 16.0 2.3 0.07 12.9 0.2 2.5 2 0 0 2 2 2 1 C2H2-type zinc-finger domain VCX_VCY PF15231.6 CCM01078.1 - 0.3 11.8 2.7 0.51 11.0 2.7 1.3 1 0 0 1 1 1 0 Variable charge X/Y family GATA PF00320.27 CCM01080.1 - 0.00074 19.1 0.5 0.0017 17.9 0.5 1.6 1 0 0 1 1 1 1 GATA zinc finger zf-MYND PF01753.18 CCM01081.1 - 1.2e-09 38.1 6.8 1.8e-09 37.5 6.8 1.3 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 CCM01081.1 - 0.011 16.1 6.1 0.023 15.0 6.1 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DUF4470 PF14737.6 CCM01082.1 - 9.2e-20 70.7 0.1 1.4e-19 70.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) F-box-like PF12937.7 CCM01083.1 - 0.0038 17.1 0.7 0.0038 17.1 0.7 2.2 2 0 0 2 2 2 1 F-box-like UCH PF00443.29 CCM01085.1 - 9.2e-55 185.9 0.0 1.5e-54 185.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM01085.1 - 2.1e-15 57.1 0.0 5.7e-14 52.4 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-MIZ PF02891.20 CCM01085.1 - 0.00069 19.3 0.3 0.003 17.3 0.1 2.3 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger Inhibitor_I66 PF16850.5 CCM01085.1 - 0.024 14.5 0.1 0.047 13.6 0.1 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I66 Herpes_UL36 PF03586.13 CCM01085.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein RicinB_lectin_2 PF14200.6 CCM01085.1 - 0.42 11.4 1.7 0.86 10.4 0.1 2.3 2 1 2 4 4 4 0 Ricin-type beta-trefoil lectin domain-like p450 PF00067.22 CCM01086.1 - 7.8e-63 212.8 0.0 2e-62 211.4 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCM01086.1 - 0.2 10.5 0.1 0.38 9.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) G-alpha PF00503.20 CCM01087.1 - 3.1e-85 286.4 0.0 2.3e-80 270.4 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit PARP PF00644.20 CCM01087.1 - 1.3e-12 47.7 1.5 3.5e-09 36.5 0.2 3.2 2 1 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Arf PF00025.21 CCM01087.1 - 1e-06 28.4 0.0 0.0017 17.8 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 CCM01087.1 - 0.0074 16.5 0.0 4.2 7.6 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCM01087.1 - 0.023 14.4 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain E1-E2_ATPase PF00122.20 CCM01088.1 - 3.8e-40 137.3 0.8 3.8e-40 137.3 0.8 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CCM01088.1 - 2e-21 77.2 0.8 7.7e-09 36.1 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCM01088.1 - 1.4e-18 66.8 0.0 2.9e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCM01088.1 - 5.8e-09 35.5 0.0 1.5e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCM01088.1 - 9.9e-08 32.0 0.2 1.8e-07 31.2 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 CCM01088.1 - 1.8e-07 31.0 0.0 1.8e-07 31.0 0.0 3.1 3 1 0 3 3 3 1 Cation transporting ATPase, C-terminus HAD PF12710.7 CCM01088.1 - 1.5e-05 25.5 0.2 0.002 18.6 0.0 3.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase PI3K_C2 PF00792.24 CCM01088.1 - 0.05 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 COesterase PF00135.28 CCM01089.1 - 2.1e-25 89.6 0.0 2.6e-25 89.3 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family F-box-like PF12937.7 CCM01090.1 - 2.9e-08 33.5 1.3 8e-08 32.1 1.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01090.1 - 0.042 13.7 0.6 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 F-box domain LRR_4 PF12799.7 CCM01090.1 - 1.6 9.3 5.3 13 6.4 0.6 4.0 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 CCM01091.1 - 2.4e-08 33.7 2.6 7.5e-08 32.1 2.6 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01091.1 - 0.018 14.9 0.1 0.15 11.9 0.1 2.6 2 1 0 2 2 2 0 F-box domain CAP59_mtransfer PF11735.8 CCM01092.1 - 6e-70 235.7 0.0 7.5e-70 235.3 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Pkinase_fungal PF17667.1 CCM01093.1 - 1.9e-15 56.6 0.0 2e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase WD40 PF00400.32 CCM01095.1 - 2.2e-110 357.4 72.1 1.3e-08 35.4 0.6 14.9 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM01095.1 - 1.3e-29 102.3 26.0 0.013 15.8 0.2 12.7 1 1 12 13 13 13 11 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCM01095.1 - 1.2e-14 54.3 1.8 0.0027 17.1 0.0 9.6 7 4 2 10 10 10 1 WD40-like domain PQQ_3 PF13570.6 CCM01095.1 - 7.8e-12 45.3 7.1 3.4 8.3 0.1 11.4 10 2 3 13 13 13 1 PQQ-like domain PD40 PF07676.12 CCM01095.1 - 1.6e-05 24.7 0.0 1.8e+02 2.2 0.0 8.6 11 0 0 11 11 11 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 CCM01095.1 - 2.2e-05 23.4 22.1 3.8 6.2 0.3 9.3 2 1 4 8 8 8 4 Nup133 N terminal like Nup160 PF11715.8 CCM01095.1 - 0.0001 21.1 19.6 2.6 6.6 0.0 8.8 7 3 3 10 10 10 2 Nucleoporin Nup120/160 PQQ PF01011.21 CCM01095.1 - 0.00019 21.2 0.1 9.2 6.4 0.0 6.0 6 0 0 6 6 6 1 PQQ enzyme repeat Frtz PF11768.8 CCM01095.1 - 0.0008 17.8 0.0 0.62 8.3 0.0 4.7 3 3 2 5 5 5 1 WD repeat-containing and planar cell polarity effector protein Fritz ChapFlgA PF13144.6 CCM01095.1 - 0.01 15.9 2.6 30 4.7 0.0 5.3 4 2 2 6 6 6 0 Chaperone for flagella basal body P-ring formation Cuticle_4 PF15955.5 CCM01095.1 - 0.084 13.6 3.7 1.3e+02 3.4 0.0 5.3 6 0 0 6 6 5 0 Cuticle protein CHAP PF05257.16 CCM01095.1 - 3.4 8.3 31.3 2.9 8.5 0.1 8.7 6 2 2 9 9 9 0 CHAP domain Pkinase_fungal PF17667.1 CCM01096.1 - 1.4e-39 136.0 0.1 4.5e-25 88.3 0.0 3.2 1 1 1 2 2 2 2 Fungal protein kinase APH PF01636.23 CCM01096.1 - 0.00029 20.9 0.0 0.00059 19.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family CUT PF02376.15 CCM01096.1 - 0.021 15.0 0.1 0.06 13.5 0.1 1.7 1 0 0 1 1 1 0 CUT domain YugN PF08868.10 CCM01096.1 - 0.053 13.4 0.2 0.13 12.1 0.2 1.7 1 0 0 1 1 1 0 YugN-like family AAA_16 PF13191.6 CCM01097.1 - 0.0017 18.7 0.1 0.0041 17.5 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CCM01097.1 - 0.0042 17.5 0.2 0.16 12.4 0.1 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Glutaredoxin2_C PF04399.13 CCM01097.1 - 0.0046 16.8 1.0 0.0099 15.7 0.1 2.0 3 0 0 3 3 3 1 Glutaredoxin 2, C terminal domain NACHT PF05729.12 CCM01097.1 - 0.0057 16.6 0.3 0.022 14.6 0.3 2.0 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 CCM01097.1 - 0.011 15.0 0.0 0.028 13.6 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain Parvo_NS1 PF01057.17 CCM01097.1 - 0.056 12.5 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_22 PF13401.6 CCM01097.1 - 0.1 12.9 0.0 4.3 7.6 0.0 3.1 2 1 0 2 2 2 0 AAA domain HEAT_EZ PF13513.6 CCM01098.1 - 0.11 13.0 0.0 0.38 11.3 0.0 1.8 2 0 0 2 2 2 0 HEAT-like repeat F-box PF00646.33 CCM01099.1 - 0.083 12.8 0.2 0.24 11.3 0.2 1.7 1 0 0 1 1 1 0 F-box domain RicinB_lectin_2 PF14200.6 CCM01100.1 - 0.0004 21.1 0.1 0.034 14.9 0.0 2.5 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Nop14 PF04147.12 CCM01100.1 - 0.041 12.1 10.0 0.051 11.8 10.0 1.1 1 0 0 1 1 1 0 Nop14-like family Astro_capsid_p PF12226.8 CCM01100.1 - 0.17 11.0 10.0 0.27 10.3 10.0 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SAPS PF04499.15 CCM01100.1 - 5.1 5.8 9.9 6.9 5.3 9.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RicinB_lectin_2 PF14200.6 CCM01101.1 - 6.5e-06 26.8 0.5 0.00065 20.4 0.1 2.2 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like Inhibitor_I66 PF16850.5 CCM01101.1 - 8.2e-05 22.5 0.0 0.00011 22.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I66 RicinB_lectin_2 PF14200.6 CCM01102.1 - 1.6e-05 25.5 0.9 0.0082 16.8 0.1 2.3 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like MRJP PF03022.16 CCM01104.1 - 1.6e-23 83.5 0.0 3.5e-23 82.4 0.0 1.4 1 1 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 CCM01104.1 - 2.1e-06 27.5 0.0 1.4e-05 24.8 0.0 2.2 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 CCM01104.1 - 0.099 12.6 1.0 1.5 8.8 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat HSF_DNA-bind PF00447.17 CCM01107.1 - 1.5e-31 108.8 1.2 2.5e-31 108.2 1.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding ANAPC8 PF04049.13 CCM01108.1 - 1.7e-22 80.0 0.1 3.6e-22 78.9 0.1 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 CCM01108.1 - 3.9e-16 58.1 0.6 0.00072 19.3 0.2 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCM01108.1 - 8.9e-14 50.4 2.3 0.0038 17.2 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01108.1 - 1.4e-10 40.5 3.8 0.00015 21.7 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM01108.1 - 4.1e-07 30.3 11.2 0.037 14.8 0.0 5.9 6 2 1 7 7 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM01108.1 - 1.2e-06 28.6 6.2 0.026 14.8 0.8 4.4 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CCM01108.1 - 1.9e-06 27.4 1.0 0.027 14.1 0.0 3.6 2 1 1 3 3 3 2 TPR repeat TPR_12 PF13424.6 CCM01108.1 - 6.9e-05 23.1 7.6 0.28 11.5 1.3 4.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM01108.1 - 0.00083 20.0 1.8 0.71 10.6 0.0 4.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCM01108.1 - 0.0037 17.2 2.8 1.7 8.9 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCM01108.1 - 0.0082 16.7 0.1 38 5.2 0.0 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCM01108.1 - 0.0094 16.4 0.4 7.6 7.1 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCM01108.1 - 0.014 15.5 0.1 8.2 6.7 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ChAPs PF09295.10 CCM01108.1 - 0.041 12.9 0.3 0.24 10.4 0.0 2.1 2 1 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) Sel1 PF08238.12 CCM01108.1 - 0.11 13.2 0.1 6.4 7.6 0.0 2.7 2 0 0 2 2 2 0 Sel1 repeat TPR_17 PF13431.6 CCM01108.1 - 0.15 12.5 0.1 1.3e+02 3.3 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCM01108.1 - 0.78 9.7 3.5 17 5.4 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat GLTSCR1 PF15249.6 CCM01109.1 - 8.8e-27 93.5 0.3 1.8e-26 92.5 0.0 1.7 2 0 0 2 2 2 1 Conserved region of unknown function on GLTSCR protein F-box-like PF12937.7 CCM01110.1 - 1.7e-05 24.6 2.2 0.00053 19.8 0.1 3.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CCM01110.1 - 0.0016 18.3 0.1 0.0045 16.8 0.1 1.8 1 0 0 1 1 1 1 F-box domain Fungal_trans PF04082.18 CCM01111.1 - 1.8e-18 66.6 0.0 3.9e-18 65.4 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM01111.1 - 5.8e-08 32.7 8.8 9.3e-08 32.1 8.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 CCM01111.1 - 0.001 19.2 0.1 0.0022 18.1 0.1 1.5 1 0 0 1 1 1 1 Gal4-like dimerisation domain Prot_inhib_II PF02428.15 CCM01111.1 - 3.9 8.0 8.3 5.4 7.5 5.4 2.4 1 1 1 2 2 2 0 Potato type II proteinase inhibitor family DUF1674 PF07896.12 CCM01112.1 - 2.9e-13 50.0 1.2 7.3e-13 48.8 1.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) DEAD PF00270.29 CCM01114.1 - 1.7e-39 135.4 0.0 2.3e-38 131.7 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM01114.1 - 8.4e-26 90.5 0.2 3.4e-25 88.5 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 CCM01114.1 - 2.9e-21 75.5 2.7 1.1e-20 73.6 2.7 2.2 1 0 0 1 1 1 1 DBP10CT (NUC160) domain TGT PF01702.18 CCM01115.1 - 1.7e-119 399.1 0.0 2e-119 398.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Omega_Repress PF07764.11 CCM01115.1 - 0.12 12.9 0.5 0.45 11.1 0.2 1.9 2 0 0 2 2 2 0 Omega Transcriptional Repressor Glyco_hydro_70 PF02324.16 CCM01115.1 - 0.17 10.0 0.0 0.24 9.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 70 tRNA-synt_1b PF00579.25 CCM01116.1 - 1.2e-72 244.7 0.0 1.6e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 CCM01116.1 - 7.5e-06 25.6 0.0 1.7e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 S4 domain Senescence PF06911.12 CCM01116.1 - 0.05 13.9 0.1 14 6.0 0.0 3.2 3 0 0 3 3 3 0 Senescence-associated protein TyrRSs_C PF16714.5 CCM01116.1 - 0.086 12.7 0.2 3 7.7 0.0 2.2 1 1 1 2 2 2 0 Tyrosyl-tRNA synthetase C-terminal domain EMP70 PF02990.16 CCM01117.1 - 7.9e-198 658.3 0.0 1.1e-197 657.9 0.0 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 TMEM40 PF15817.5 CCM01117.1 - 1.5 8.6 4.2 4.7 7.0 4.2 1.9 1 0 0 1 1 1 0 Transmembrane protein 40 family F-box-like PF12937.7 CCM01118.1 - 7.9e-05 22.5 0.1 0.00024 20.9 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM01118.1 - 0.00028 20.7 0.0 0.00073 19.3 0.0 1.7 1 0 0 1 1 1 1 F-box domain BAR PF03114.18 CCM01120.1 - 1.3e-45 155.9 1.0 7.3e-45 153.5 1.0 1.8 1 1 0 1 1 1 1 BAR domain Metal_resist PF13801.6 CCM01120.1 - 0.12 12.6 0.8 0.68 10.1 0.0 2.4 3 0 0 3 3 3 0 Heavy-metal resistance DUF2367 PF10164.9 CCM01122.1 - 3.2e-07 30.8 10.1 1.1e-06 29.1 10.0 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) adh_short PF00106.25 CCM01123.1 - 8.1e-21 74.4 0.2 2.3e-20 72.9 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_25 PF13649.6 CCM01123.1 - 1.4e-14 54.5 0.0 2.6e-13 50.5 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM01123.1 - 4.6e-13 49.2 0.0 1.2e-11 44.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM01123.1 - 5.3e-11 43.0 0.0 1.8e-10 41.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CCM01123.1 - 1.2e-10 41.3 0.0 1.9e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) adh_short_C2 PF13561.6 CCM01123.1 - 1.2e-10 41.3 0.0 2.3e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01123.1 - 3.8e-08 33.4 0.1 7e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 KR domain Methyltransf_9 PF08003.11 CCM01123.1 - 1.4e-07 30.7 0.0 2.4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 CCM01123.1 - 1.5e-07 31.4 0.0 3.8e-07 30.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM01123.1 - 1.8e-05 25.4 0.0 4.4e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCM01123.1 - 2e-05 24.0 0.0 3.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 CCM01123.1 - 3e-05 23.6 0.1 5.4e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CCM01123.1 - 0.00013 21.4 0.0 0.00028 20.3 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CCM01123.1 - 0.0014 18.8 0.0 0.024 14.8 0.0 2.2 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.7 CCM01123.1 - 0.003 17.5 0.0 0.0077 16.2 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.19 CCM01123.1 - 0.003 17.3 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 CCM01123.1 - 0.0041 16.6 0.0 0.0088 15.5 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Epimerase PF01370.21 CCM01123.1 - 0.0078 15.7 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_32 PF13679.6 CCM01123.1 - 0.012 15.6 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CCM01123.1 - 0.035 13.8 0.1 0.065 13.0 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 CCM01123.1 - 0.054 14.5 0.0 0.29 12.2 0.0 2.3 2 0 0 2 2 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 CCM01123.1 - 0.063 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 WD40 PF00400.32 CCM01124.1 - 4.7e-42 141.2 25.7 4.1e-08 33.8 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM01124.1 - 6.1e-08 32.9 0.7 0.094 13.0 0.0 4.8 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCM01124.1 - 0.00056 18.7 4.5 0.024 13.3 0.2 3.4 3 1 1 4 4 4 1 Nucleoporin Nup120/160 PD40 PF07676.12 CCM01124.1 - 0.00071 19.4 2.5 2.9 7.9 0.0 4.6 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 CCM01124.1 - 0.0037 16.4 0.0 0.62 9.1 0.0 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF1513) Cytochrom_D1 PF02239.16 CCM01124.1 - 0.042 12.4 0.1 1.3 7.5 0.2 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF1416 PF07210.12 CCM01124.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1416) IU_nuc_hydro PF01156.19 CCM01125.1 - 4.1e-60 203.9 0.0 5e-60 203.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MFS_1 PF07690.16 CCM01126.1 - 8.8e-16 57.8 35.5 1.4e-15 57.1 35.5 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily bZIP_1 PF00170.21 CCM01128.1 - 0.00017 21.6 2.7 0.0004 20.4 2.7 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCM01128.1 - 0.0049 16.9 3.3 0.0088 16.1 3.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper HALZ PF02183.18 CCM01128.1 - 0.83 9.9 3.6 1.5 9.1 3.6 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF1556 PF07590.11 CCM01129.1 - 7.6 6.9 7.7 9 6.7 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1556) EXS PF03124.14 CCM01131.1 - 7.5e-60 203.0 0.4 9.4e-60 202.7 0.4 1.1 1 0 0 1 1 1 1 EXS family 2-Hacid_dh_C PF02826.19 CCM01131.1 - 9.8e-47 158.6 0.0 1.4e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM01131.1 - 1.4e-17 63.6 0.0 2.3e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain DUF776 PF05604.11 CCM01132.1 - 0.051 13.9 0.6 0.067 13.6 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF776) Bromodomain PF00439.25 CCM01133.1 - 3.2e-25 88.0 0.4 5.5e-25 87.3 0.4 1.4 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 CCM01133.1 - 4.9e-06 26.8 0.0 9.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM01133.1 - 5.6e-05 23.1 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM01133.1 - 0.002 18.5 0.2 0.0039 17.6 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DPBB_1 PF03330.18 CCM01134.1 - 5.6e-05 23.3 0.3 0.00016 21.9 0.0 1.9 2 0 0 2 2 2 1 Lytic transglycolase DUF952 PF06108.12 CCM01135.1 - 3.3e-23 81.5 0.0 4.4e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Pro_isomerase PF00160.21 CCM01136.1 - 2.9e-48 164.1 0.1 3.5e-48 163.9 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DEAD PF00270.29 CCM01137.1 - 2.6e-39 134.8 0.0 4.9e-39 133.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM01137.1 - 2.7e-17 63.1 0.0 9.5e-16 58.1 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCM01137.1 - 6.7e-17 61.5 0.3 4.5e-16 58.8 0.5 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCM01137.1 - 0.00041 20.4 0.0 0.00082 19.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MOZ_SAS PF01853.18 CCM01138.1 - 1.8e-77 259.0 0.1 2.8e-77 258.4 0.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CCM01138.1 - 5.4e-23 80.4 0.8 9.7e-23 79.5 0.8 1.4 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 CCM01138.1 - 6.1e-18 64.5 0.0 1.1e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CCM01138.1 - 0.00052 20.4 0.0 0.0055 17.1 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM01138.1 - 0.0023 18.2 0.0 0.023 14.9 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family HTH_11 PF08279.12 CCM01138.1 - 0.01 15.7 0.0 0.032 14.2 0.0 1.8 1 0 0 1 1 1 0 HTH domain LAG1-DNAbind PF09271.11 CCM01140.1 - 1.2e-50 172.0 0.0 2.2e-50 171.2 0.0 1.4 1 0 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 CCM01140.1 - 3.9e-20 72.6 0.0 1.9e-18 67.1 0.0 2.7 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain XhlA PF10779.9 CCM01142.1 - 0.013 15.7 1.0 0.03 14.5 1.0 1.6 1 0 0 1 1 1 0 Haemolysin XhlA HrpB7 PF09486.10 CCM01142.1 - 0.018 15.5 3.3 0.018 15.5 3.3 2.0 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) ABC_tran_CTD PF16326.5 CCM01142.1 - 0.098 12.9 2.0 0.19 12.0 1.2 1.9 1 1 0 1 1 1 0 ABC transporter C-terminal domain Spc7 PF08317.11 CCM01142.1 - 0.46 9.3 3.1 0.67 8.8 3.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Hamartin PF04388.12 CCM01142.1 - 2.6 6.6 7.3 6.6 5.3 0.7 2.1 2 0 0 2 2 2 0 Hamartin protein Pkinase PF00069.25 CCM01143.1 - 1e-50 172.6 0.6 2.4e-50 171.4 0.6 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01143.1 - 1e-21 77.4 0.0 1.7e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM01143.1 - 0.00051 20.0 0.1 0.00051 20.0 0.1 2.7 3 0 0 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCM01143.1 - 0.0011 18.6 0.1 0.0026 17.4 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 CCM01143.1 - 0.05 13.2 0.5 0.13 11.8 0.5 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Put_Phosphatase PF06888.12 CCM01144.1 - 1.6e-07 31.0 0.3 1.8e-07 30.8 0.3 1.0 1 0 0 1 1 1 1 Putative Phosphatase BSD PF03909.17 CCM01145.1 - 1.5e-17 63.3 0.1 1.9e-14 53.4 0.1 3.0 2 0 0 2 2 2 2 BSD domain YCII PF03795.14 CCM01146.1 - 4.2e-11 43.1 0.0 5.2e-11 42.8 0.0 1.0 1 0 0 1 1 1 1 YCII-related domain CASP_C PF08172.12 CCM01147.1 - 2.6e-78 262.9 0.9 2.6e-78 262.9 0.9 3.8 2 1 1 3 3 3 1 CASP C terminal DUF1192 PF06698.11 CCM01147.1 - 0.0097 15.9 0.5 0.0097 15.9 0.5 5.0 6 0 0 6 6 6 1 Protein of unknown function (DUF1192) CtIP_N PF10482.9 CCM01147.1 - 0.032 14.3 0.9 0.032 14.3 0.9 5.6 3 1 1 5 5 5 0 Tumour-suppressor protein CtIP N-terminal domain KLRAQ PF10205.9 CCM01147.1 - 0.038 14.2 0.1 0.038 14.2 0.1 5.6 4 1 1 6 6 6 0 Predicted coiled-coil domain-containing protein Shugoshin_N PF07558.11 CCM01147.1 - 0.16 11.9 0.2 0.16 11.9 0.2 5.5 6 0 0 6 6 6 0 Shugoshin N-terminal coiled-coil region Ribosomal_S9 PF00380.19 CCM01148.1 - 2.9e-43 147.2 0.0 5.6e-43 146.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 BRE1 PF08647.11 CCM01149.1 - 1.7e-21 76.1 9.4 1.7e-21 76.1 9.4 7.5 4 2 3 8 8 8 2 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 CCM01149.1 - 0.087 12.7 3.3 0.17 11.8 3.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TMEM192 PF14802.6 CCM01149.1 - 0.45 9.6 12.6 0.19 10.8 0.5 3.8 4 0 0 4 4 4 0 TMEM192 family NPV_P10 PF05531.12 CCM01149.1 - 3.1 8.3 17.5 0.56 10.7 0.2 5.9 5 1 0 6 6 6 0 Nucleopolyhedrovirus P10 protein Suppressor_APC PF11414.8 CCM01149.1 - 8.9 6.5 18.4 0.95 9.6 0.3 5.4 5 0 0 5 5 5 0 Adenomatous polyposis coli tumour suppressor protein DASH_Duo1 PF08651.10 CCM01150.1 - 2.5e-20 72.0 1.7 4.7e-20 71.1 1.7 1.5 1 0 0 1 1 1 1 DASH complex subunit Duo1 Dickkopf_N PF04706.12 CCM01150.1 - 0.11 12.9 23.8 0.048 14.1 7.5 3.4 3 0 0 3 3 3 0 Dickkopf N-terminal cysteine-rich region LapA_dom PF06305.11 CCM01150.1 - 1.1 9.1 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Atrophin-1 PF03154.15 CCM01150.1 - 9.4 4.4 12.2 18 3.5 12.2 1.5 1 0 0 1 1 1 0 Atrophin-1 family DUF5578 PF17741.1 CCM01151.1 - 0.1 12.0 0.1 0.15 11.4 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5578) Protamine_P2 PF00841.19 CCM01151.1 - 0.15 12.6 5.1 0.34 11.4 5.1 1.6 1 0 0 1 1 1 0 Sperm histone P2 Ssl1 PF04056.14 CCM01152.1 - 4.5e-63 212.6 0.0 6.8e-63 212.0 0.0 1.3 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 CCM01152.1 - 4.7e-09 36.8 0.0 1.6e-08 35.1 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain Tfb4 PF03850.14 CCM01152.1 - 0.3 10.5 8.0 6.9 6.1 0.0 2.1 2 0 0 2 2 2 0 Transcription factor Tfb4 ADH_N PF08240.12 CCM01153.1 - 1.6e-26 92.4 1.0 2.5e-26 91.7 1.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM01153.1 - 2.9e-12 46.7 0.0 8.7e-12 45.1 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM01153.1 - 1.4e-07 32.6 0.0 2.1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCM01153.1 - 3.8e-05 23.1 0.0 6.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCM01153.1 - 0.00011 21.7 0.3 0.00018 20.9 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CCM01153.1 - 0.07 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 CCM01153.1 - 0.071 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_N PF08240.12 CCM01154.1 - 4e-27 94.2 3.5 6.7e-27 93.5 3.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM01154.1 - 5.6e-11 42.5 0.0 1.1e-10 41.5 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCM01154.1 - 3.5e-05 23.2 0.0 6.3e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCM01154.1 - 0.00014 21.2 0.0 0.00023 20.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CCM01154.1 - 0.00032 21.8 0.0 0.00054 21.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_2 PF03446.15 CCM01154.1 - 0.015 15.5 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase zf-NADH-PPase PF09297.11 CCM01154.1 - 1.8 8.3 5.4 5.6 6.7 0.4 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Peptidase_C1_2 PF03051.15 CCM01155.1 - 6.1e-153 509.7 0.0 7.6e-153 509.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 CCM01155.1 - 6e-06 26.5 0.1 0.11 12.6 0.0 2.4 2 1 0 2 2 2 2 Papain family cysteine protease Phage_portal_2 PF05136.13 CCM01155.1 - 0.15 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Phage portal protein, lambda family RabGAP-TBC PF00566.18 CCM01156.1 - 2.3e-52 177.7 0.1 2.3e-52 177.7 0.1 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain ABC1 PF03109.16 CCM01156.1 - 1.2e-32 112.6 0.0 2.7e-32 111.5 0.0 1.7 1 0 0 1 1 1 1 ABC1 family SAWADEE PF16719.5 CCM01156.1 - 0.0036 17.3 0.1 0.0079 16.2 0.1 1.5 1 0 0 1 1 1 1 SAWADEE domain Cep57_CLD_2 PF14197.6 CCM01156.1 - 0.13 12.4 6.8 0.44 10.7 6.8 1.9 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 PC4 PF02229.16 CCM01157.1 - 1.5e-16 59.7 0.9 6.2e-16 57.8 0.6 2.2 2 1 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) DUF4551 PF15087.6 CCM01157.1 - 0.24 10.2 2.6 0.28 10.0 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC45 PF02724.14 CCM01157.1 - 3 6.0 6.5 3.4 5.8 6.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 CCM01158.1 - 2e-95 319.9 0.0 2e-95 319.9 0.0 4.5 4 1 0 4 4 4 1 Domain of Unknown Function (DUF913) HECT PF00632.25 CCM01158.1 - 2.2e-94 316.4 0.0 4.7e-94 315.3 0.0 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 CCM01158.1 - 1.9e-89 300.6 1.6 1.9e-89 300.6 1.6 3.5 3 0 0 3 3 3 1 Domain of Unknown Function (DUF908) UBM PF14377.6 CCM01158.1 - 5.1e-31 105.2 14.3 1.7e-11 43.2 0.9 4.4 4 0 0 4 4 4 3 Ubiquitin binding region UBA PF00627.31 CCM01158.1 - 1.7e-11 43.8 0.1 4.1e-11 42.5 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain ADH_zinc_N PF00107.26 CCM01159.1 - 1.7e-08 34.5 0.6 2.3e-08 34.1 0.6 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CCM01159.1 - 0.025 14.0 0.6 0.035 13.5 0.6 1.2 1 0 0 1 1 1 0 short chain dehydrogenase APG5 PF04106.12 CCM01160.1 - 5.4e-62 209.4 0.0 6.8e-62 209.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 Git3 PF11710.8 CCM01162.1 - 5.5e-09 36.1 11.9 9.2e-09 35.4 11.9 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.11 CCM01162.1 - 0.0014 17.9 9.7 0.002 17.3 9.7 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 CCM01162.1 - 0.012 15.6 0.1 0.038 14.1 0.1 1.8 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term CRAL_TRIO PF00650.20 CCM01164.1 - 4.4e-39 133.7 0.0 6.7e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCM01164.1 - 7.8e-05 22.8 2.4 0.00014 22.0 2.4 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CCM01164.1 - 0.0045 17.1 0.0 0.0068 16.6 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF4821 PF16092.5 CCM01166.1 - 0.069 12.8 0.1 0.088 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) RRM_1 PF00076.22 CCM01168.1 - 2e-08 33.9 2.1 0.00093 19.0 0.0 4.6 5 0 0 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XPG_I PF00867.18 CCM01169.1 - 1.5e-29 102.1 0.0 4.4e-29 100.7 0.0 1.8 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 CCM01169.1 - 1.8e-29 102.2 0.0 3.8e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 CCM01169.1 - 4.7e-06 27.1 0.1 1.2e-05 25.9 0.1 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold YEATS PF03366.16 CCM01170.1 - 0.043 13.8 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 YEATS family Na_H_Exchanger PF00999.21 CCM01172.1 - 9.1e-61 205.7 28.8 1.1e-60 205.5 28.8 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF1965 PF09248.10 CCM01172.1 - 0.16 11.8 0.2 1.5 8.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1965) Amino_oxidase PF01593.24 CCM01173.1 - 8.5e-20 71.5 0.0 2.5e-15 56.7 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CCM01173.1 - 5.7e-15 55.3 0.1 3.1e-14 53.0 0.0 2.3 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCM01173.1 - 5.5e-05 23.2 0.0 0.0036 17.3 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 CCM01173.1 - 0.0012 18.5 0.1 0.0067 16.0 0.0 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM01173.1 - 0.083 12.1 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Rif1_N PF12231.8 CCM01174.1 - 0.0076 15.3 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal GPI-anchored PF10342.9 CCM01175.1 - 1.3e-07 32.3 0.1 1.7e-07 31.9 0.1 1.2 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family FKBP_C PF00254.28 CCM01177.1 - 1.1e-28 99.3 0.0 2e-28 98.5 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Sugar_tr PF00083.24 CCM01177.1 - 3e-18 65.9 15.0 7.1e-18 64.7 3.6 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCM01177.1 - 1.3e-16 60.5 45.0 4.1e-14 52.3 12.6 2.9 2 1 0 2 2 2 2 Major Facilitator Superfamily KxDL PF10241.9 CCM01178.1 - 0.0016 18.6 3.2 0.027 14.7 0.6 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein NICE-3 PF07406.11 CCM01178.1 - 0.0019 18.2 0.9 0.0024 17.9 0.9 1.2 1 0 0 1 1 1 1 NICE-3 protein DUF2408 PF10303.9 CCM01178.1 - 0.0062 17.1 1.8 0.0076 16.8 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) PRTase_1 PF11202.8 CCM01178.1 - 0.011 15.0 0.2 1.2 8.3 0.2 2.0 2 0 0 2 2 2 0 Phosphoribosyl transferase (PRTase) DUF2465 PF10239.9 CCM01178.1 - 0.021 14.1 0.3 0.039 13.2 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2465) PE PF00934.20 CCM01178.1 - 0.045 14.1 2.0 3.4 8.1 1.0 2.8 1 1 1 2 2 2 0 PE family PCRF PF03462.18 CCM01178.1 - 0.088 12.7 2.4 0.1 12.4 2.4 1.2 1 0 0 1 1 1 0 PCRF domain CR6_interact PF10147.9 CCM01178.1 - 0.12 12.1 2.8 0.14 11.9 2.1 1.4 1 1 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Exonuc_VII_L PF02601.15 CCM01178.1 - 0.13 11.8 2.4 0.17 11.4 2.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ANAPC4 PF12896.7 CCM01178.1 - 0.21 11.1 1.9 2.1 7.8 0.6 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 Q_salvage PF10343.9 CCM01179.1 - 5.5e-90 301.8 0.0 6.9e-90 301.4 0.0 1.0 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family Trimer_CC PF08954.11 CCM01179.1 - 0.17 11.5 0.5 0.42 10.2 0.5 1.6 1 0 0 1 1 1 0 Trimerisation motif Rft-1 PF04506.13 CCM01181.1 - 3.1e-140 468.3 15.9 3.5e-140 468.1 15.9 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 CCM01181.1 - 7.1e-08 32.0 9.4 7.1e-08 32.0 9.4 2.3 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein DUF5516 PF17637.2 CCM01181.1 - 0.19 11.5 0.9 0.52 10.1 0.9 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5516) SHMT PF00464.19 CCM01182.1 - 1.3e-169 564.1 0.0 1.5e-169 563.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 CCM01182.1 - 0.0008 18.8 0.0 0.0034 16.7 0.0 1.8 2 0 0 2 2 2 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CCM01182.1 - 0.0045 16.4 0.0 0.0068 15.8 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family MLTR_LBD PF17765.1 CCM01182.1 - 0.025 14.7 0.4 0.067 13.3 0.4 1.7 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain Glyco_hydro_18 PF00704.28 CCM01183.1 - 4.2e-60 204.1 1.4 5e-60 203.9 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF390 PF04094.14 CCM01183.1 - 0.23 9.7 2.7 0.38 9.0 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF390) HET PF06985.11 CCM01184.1 - 9.3e-09 35.8 0.2 3.8e-05 24.1 0.0 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) COesterase PF00135.28 CCM01185.1 - 1.2e-57 196.0 0.0 4.1e-57 194.2 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM01185.1 - 0.0026 17.6 0.2 0.014 15.2 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF1749 PF08538.10 CCM01185.1 - 0.0076 15.4 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) COX14 PF14880.6 CCM01186.1 - 0.092 12.6 0.5 0.11 12.3 0.5 1.1 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Oxidored-like PF09791.9 CCM01187.1 - 7.5e-18 63.9 0.4 1.2e-17 63.2 0.4 1.4 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal CSN5_C PF18323.1 CCM01188.1 - 2.1e-26 92.6 2.6 3.5e-26 91.9 2.6 1.4 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain JAB PF01398.21 CCM01188.1 - 4.7e-23 81.4 0.1 8.8e-23 80.5 0.1 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Paramyxo_C PF01692.18 CCM01188.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C Prok-JAB PF14464.6 CCM01188.1 - 0.17 11.6 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain Aldedh PF00171.22 CCM01190.1 - 8.5e-82 275.1 0.0 4.1e-78 263.0 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family LPD7 PF18821.1 CCM01190.1 - 0.081 13.1 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 7 Ribosomal_S7 PF00177.21 CCM01191.1 - 4.5e-29 101.0 0.5 6e-29 100.6 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Mg_trans_NIPA PF05653.14 CCM01192.1 - 1.6e-102 342.6 15.0 2e-102 342.3 15.0 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CCM01192.1 - 0.0011 19.1 5.1 0.0011 19.1 5.1 3.4 3 0 0 3 3 3 1 EamA-like transporter family Creatinase_N_2 PF16189.5 CCM01193.1 - 1.6e-51 174.6 0.0 6.8e-51 172.6 0.0 1.9 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CCM01193.1 - 3.4e-46 157.6 0.0 5e-46 157.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 CCM01193.1 - 1.6e-20 74.1 0.0 1.3e-16 61.5 0.0 2.3 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain 4HBT PF03061.22 CCM01193.1 - 0.0082 16.5 0.1 0.019 15.3 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily F-box-like PF12937.7 CCM01194.1 - 1.2e-05 25.1 0.8 3.8e-05 23.5 0.8 1.9 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.13 CCM01194.1 - 0.0021 18.6 0.3 0.013 16.1 0.1 2.5 2 0 0 2 2 2 1 Leucine Rich Repeat F-box PF00646.33 CCM01194.1 - 0.2 11.6 3.7 0.28 11.1 0.8 2.9 2 1 0 2 2 2 0 F-box domain adh_short PF00106.25 CCM01195.1 - 2.3e-56 190.4 1.8 3e-56 190.0 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01195.1 - 3.5e-55 187.1 1.7 4.3e-55 186.8 1.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01195.1 - 7e-11 42.4 0.7 1.3e-10 41.4 0.7 1.4 1 1 0 1 1 1 1 KR domain Transketolase_C PF02780.20 CCM01195.1 - 0.054 13.4 1.2 0.41 10.5 0.3 2.3 2 0 0 2 2 2 0 Transketolase, C-terminal domain adh_short PF00106.25 CCM01196.1 - 2.2e-54 183.9 0.8 2.8e-54 183.6 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01196.1 - 1.8e-53 181.5 0.1 2.7e-53 180.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01196.1 - 2e-08 34.3 1.1 3e-08 33.8 1.1 1.2 1 0 0 1 1 1 1 KR domain HMG-CoA_red PF00368.18 CCM01197.1 - 1.7e-141 471.5 7.8 2.3e-141 471.1 7.8 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 CCM01197.1 - 4.9e-19 68.7 0.3 1.3e-18 67.3 0.3 1.7 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CCM01197.1 - 0.0028 15.8 0.1 0.0036 15.4 0.1 1.1 1 0 0 1 1 1 1 Patched family p450 PF00067.22 CCM01198.1 - 1.4e-64 218.5 0.0 8.9e-58 196.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Trm56 PF01994.16 CCM01198.1 - 0.13 12.2 0.0 47 3.9 0.0 3.3 3 0 0 3 3 3 0 tRNA ribose 2'-O-methyltransferase, aTrm56 Ion_trans_2 PF07885.16 CCM01199.1 - 5.2e-29 100.0 34.6 2.3e-15 56.3 11.9 3.3 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CCM01199.1 - 0.024 13.9 13.8 0.18 11.0 3.6 2.5 2 1 0 2 2 2 0 Ion transport protein DUF2207 PF09972.9 CCM01199.1 - 0.71 8.6 5.6 1.1 8.0 0.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ribosomal_L41 PF05162.13 CCM01199.1 - 5.5 7.1 11.2 0.21 11.7 4.8 2.0 2 0 0 2 2 2 0 Ribosomal protein L41 Pribosyltran PF00156.27 CCM01200.1 - 7.9e-16 58.0 0.2 1.1e-15 57.5 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain 2-Hacid_dh_C PF02826.19 CCM01201.1 - 3e-39 134.2 0.0 5.5e-39 133.4 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM01201.1 - 4e-21 75.1 0.0 4.8e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCM01201.1 - 0.0015 18.7 0.0 0.0045 17.2 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCM01201.1 - 0.0016 19.0 0.0 0.0032 18.0 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent p450 PF00067.22 CCM01202.1 - 3.7e-64 217.2 0.0 4.4e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BioW PF03744.13 CCM01202.1 - 0.047 13.2 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase p450 PF00067.22 CCM01203.1 - 8.3e-70 235.8 0.0 1e-69 235.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3848 PF12959.7 CCM01203.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3848) fn3_2 PF16893.5 CCM01204.1 - 4e-38 129.4 1.3 5.7e-38 128.9 0.2 1.8 2 0 0 2 2 2 1 Fibronectin type III domain CHS5_N PF16892.5 CCM01204.1 - 7.4e-26 89.9 0.1 7.4e-26 89.9 0.1 2.0 2 0 0 2 2 2 1 Chitin biosynthesis protein CHS5 N-terminus DER1 PF04511.15 CCM01204.1 - 2.5e-24 86.3 3.7 9.7e-24 84.4 3.7 1.8 1 1 0 1 1 1 1 Der1-like family BRCT PF00533.26 CCM01204.1 - 1e-08 35.4 0.0 1.9e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CCM01204.1 - 3.6e-06 26.8 0.0 2.4e-05 24.2 0.0 2.3 1 1 0 1 1 1 1 twin BRCT domain fn3 PF00041.21 CCM01204.1 - 0.00018 21.8 0.3 0.00054 20.2 0.3 1.8 1 1 0 1 1 1 1 Fibronectin type III domain BRCT_2 PF16589.5 CCM01204.1 - 0.00066 20.0 0.0 0.0014 19.0 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF3006 PF11213.8 CCM01204.1 - 0.001 19.3 0.0 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) Auxin_repressed PF05564.12 CCM01204.1 - 1.9 9.2 9.7 47 4.7 0.0 2.9 2 1 1 3 3 3 0 Dormancy/auxin associated protein p450 PF00067.22 CCM01205.1 - 2.4e-58 198.0 0.0 2.8e-58 197.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM01206.1 - 2.7e-70 237.4 0.0 3.3e-70 237.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1319 PF07028.11 CCM01206.1 - 0.17 12.1 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Transp_cyt_pur PF02133.15 CCM01207.1 - 2.5e-33 115.6 30.7 4.1e-32 111.5 30.7 2.0 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin PIGA PF08288.12 CCM01208.1 - 3.2e-37 127.0 0.4 1e-36 125.4 0.4 1.9 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 CCM01208.1 - 1.7e-27 96.5 2.5 2.7e-27 95.8 2.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CCM01208.1 - 2.9e-23 82.3 0.0 5.7e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCM01208.1 - 9.1e-22 77.9 0.1 3.4e-21 76.1 0.1 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CCM01208.1 - 3.1e-12 47.2 0.3 5.8e-12 46.3 0.3 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 CCM01208.1 - 0.00028 20.9 0.1 0.0005 20.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 CCM01208.1 - 0.0011 19.3 0.0 0.0033 17.8 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 CCM01208.1 - 0.023 14.4 0.0 1.9 8.1 0.0 2.3 2 0 0 2 2 2 0 Starch synthase catalytic domain Oxysterol_BP PF01237.18 CCM01209.1 - 1e-43 149.6 1.3 2.2e-21 76.1 0.0 3.3 2 1 1 3 3 3 3 Oxysterol-binding protein Caskin1-CID PF16600.5 CCM01209.1 - 0.43 11.2 4.7 0.94 10.1 4.7 1.5 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain AAA_33 PF13671.6 CCM01210.1 - 3.5e-19 69.4 0.0 4.2e-11 43.2 0.0 2.1 1 1 1 2 2 2 2 AAA domain dNK PF01712.19 CCM01210.1 - 5e-05 23.3 0.0 0.042 13.7 0.0 2.1 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_18 PF13238.6 CCM01210.1 - 6e-05 23.6 0.0 0.0074 16.8 0.0 2.2 1 1 1 2 2 2 1 AAA domain tRNA_lig_kinase PF08303.11 CCM01210.1 - 8.6e-05 22.7 0.0 0.00037 20.6 0.0 1.8 1 1 0 1 1 1 1 tRNA ligase kinase domain APS_kinase PF01583.20 CCM01210.1 - 0.00032 20.6 0.0 0.0013 18.7 0.0 1.8 1 1 0 2 2 2 1 Adenylylsulphate kinase Zeta_toxin PF06414.12 CCM01210.1 - 0.0057 16.0 0.0 0.15 11.3 0.0 2.1 1 1 1 2 2 2 1 Zeta toxin AAA_29 PF13555.6 CCM01210.1 - 0.0089 15.7 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CCM01210.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 CCM01210.1 - 0.014 14.9 0.0 0.24 10.8 0.0 2.0 1 1 1 2 2 2 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 CCM01210.1 - 0.034 14.7 0.0 0.044 14.3 0.0 1.2 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 CCM01210.1 - 0.04 13.9 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CCM01210.1 - 0.071 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein 6PF2K PF01591.18 CCM01210.1 - 0.083 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_PrkA PF08298.11 CCM01210.1 - 0.086 11.7 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain AAA_16 PF13191.6 CCM01210.1 - 0.12 12.7 0.1 0.16 12.3 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 CCM01210.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 CCM01210.1 - 0.17 11.0 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Mg_chelatase PF01078.21 CCM01210.1 - 0.18 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 CCM01210.1 - 0.2 10.8 0.0 0.32 10.1 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Thymidylate_kin PF02223.17 CCM01210.1 - 0.23 11.1 0.0 15 5.2 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase ATP_bind_1 PF03029.17 CCM01210.1 - 0.25 11.1 0.0 0.39 10.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF2754 PF10953.8 CCM01211.1 - 0.025 14.8 0.2 0.056 13.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) TPR_2 PF07719.17 CCM01212.1 - 2.6e-14 52.1 1.7 4e-05 23.4 0.0 4.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM01212.1 - 8.2e-14 51.0 3.5 3.1e-07 30.0 0.1 4.4 1 1 3 4 4 4 3 TPR repeat TPR_16 PF13432.6 CCM01212.1 - 2.9e-13 50.2 1.3 4.4e-05 24.0 1.4 2.5 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM01212.1 - 3.5e-12 45.6 1.4 4.2e-06 26.3 0.0 5.3 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCM01212.1 - 7.3e-11 41.7 0.4 0.0041 17.4 0.0 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCM01212.1 - 2.7e-10 40.4 4.2 0.00024 21.3 0.0 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCM01212.1 - 3.6e-09 36.7 4.3 0.12 13.2 0.0 4.5 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCM01212.1 - 9.7e-09 35.6 1.7 0.00023 21.6 0.3 3.2 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01212.1 - 2.8e-07 30.2 0.3 0.13 12.6 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM01212.1 - 3e-06 27.4 0.4 0.025 14.8 0.2 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 CCM01212.1 - 3.6e-06 26.6 3.1 0.49 10.3 0.0 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 CCM01212.1 - 8.8e-06 25.1 0.5 1.2e-05 24.7 0.5 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCM01212.1 - 6.5e-05 23.0 0.9 0.043 14.0 1.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCM01212.1 - 0.00012 21.8 2.1 6 7.1 0.0 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 CCM01212.1 - 0.00087 19.6 0.7 0.12 12.8 0.1 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC5 PF12862.7 CCM01212.1 - 0.0046 17.0 0.2 0.01 15.9 0.1 1.8 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 5 TPR_6 PF13174.6 CCM01212.1 - 0.0068 17.0 0.3 4.5 8.1 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF3856 PF12968.7 CCM01212.1 - 0.049 13.7 0.6 4.1 7.5 0.6 2.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) Csm1_N PF18504.1 CCM01212.1 - 0.051 13.9 0.1 0.051 13.9 0.1 2.6 4 0 0 4 4 3 0 Csm1 N-terminal domain TPR_5 PF12688.7 CCM01212.1 - 0.059 13.6 0.1 0.91 9.8 0.0 2.3 2 1 0 2 2 2 0 Tetratrico peptide repeat Exonuc_VII_S PF02609.16 CCM01212.1 - 0.2 11.8 2.2 3.1 7.9 0.2 2.9 3 1 0 3 3 2 0 Exonuclease VII small subunit TPR_4 PF07721.14 CCM01212.1 - 0.77 10.6 0.1 0.77 10.6 0.1 3.9 5 0 0 5 5 3 0 Tetratricopeptide repeat Amnionless PF14828.6 CCM01213.1 - 0.053 12.4 0.0 0.069 12.0 0.0 1.1 1 0 0 1 1 1 0 Amnionless DUF5305 PF17231.2 CCM01213.1 - 0.08 12.3 0.0 0.18 11.2 0.0 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5305) Mid2 PF04478.12 CCM01213.1 - 0.28 11.0 4.3 0.097 12.5 1.2 1.8 1 1 0 1 1 1 0 Mid2 like cell wall stress sensor Gly-zipper_Omp PF13488.6 CCM01213.1 - 0.78 9.8 7.9 1.5 8.9 7.9 1.4 1 0 0 1 1 1 0 Glycine zipper CorA PF01544.18 CCM01214.1 - 8e-12 45.1 1.2 1.2e-11 44.4 1.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein BacA PF02673.18 CCM01214.1 - 0.051 13.3 0.2 0.078 12.7 0.2 1.2 1 0 0 1 1 1 0 Bacitracin resistance protein BacA SAS-6_N PF16531.5 CCM01214.1 - 0.083 13.5 0.3 0.17 12.5 0.3 1.5 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal PhetRS_B1 PF18262.1 CCM01214.1 - 0.1 12.8 0.5 0.39 11.0 0.5 2.0 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain Phage_holin_3_6 PF07332.11 CCM01214.1 - 0.24 11.5 2.6 0.9 9.6 2.6 2.0 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III AAA PF00004.29 CCM01215.1 - 3.1e-46 157.1 0.0 2e-42 144.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_12 PF13087.6 CCM01215.1 - 1.9e-40 138.6 0.0 3.1e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCM01215.1 - 3.7e-31 108.8 0.0 7.5e-14 52.1 0.0 3.4 2 1 1 3 3 3 3 AAA domain AAA_30 PF13604.6 CCM01215.1 - 8.4e-17 61.5 0.0 4.2e-13 49.4 0.0 3.4 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCM01215.1 - 9.1e-15 55.3 0.1 1.5e-10 41.6 0.0 3.9 3 1 0 3 3 2 2 AAA domain AAA_lid_3 PF17862.1 CCM01215.1 - 3.4e-11 42.7 0.3 1.4e-10 40.8 0.1 2.1 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 CCM01215.1 - 1.2e-08 35.3 0.2 0.031 14.6 0.1 4.1 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCM01215.1 - 1.4e-08 35.3 0.1 0.00041 20.8 0.0 3.3 2 1 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CCM01215.1 - 4e-08 33.4 0.0 4.1e-05 23.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) PhoH PF02562.16 CCM01215.1 - 1e-07 31.6 0.0 0.58 9.6 0.0 3.9 4 0 0 4 4 4 3 PhoH-like protein AAA_2 PF07724.14 CCM01215.1 - 2.4e-07 31.0 0.0 7e-07 29.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) Prot_ATP_ID_OB PF16450.5 CCM01215.1 - 8.1e-07 28.9 0.7 8.1e-07 28.9 0.7 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain UvrD-helicase PF00580.21 CCM01215.1 - 1.4e-05 24.8 0.0 0.043 13.3 0.0 2.8 3 0 0 3 3 3 2 UvrD/REP helicase N-terminal domain RuvB_N PF05496.12 CCM01215.1 - 2.4e-05 24.1 0.0 0.00069 19.4 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CCM01215.1 - 4.1e-05 23.1 0.2 0.076 12.4 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CCM01215.1 - 7.8e-05 22.3 0.0 0.21 11.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 CCM01215.1 - 0.00013 22.5 0.0 0.097 13.2 0.0 3.9 4 0 0 4 4 3 1 AAA domain ResIII PF04851.15 CCM01215.1 - 0.00018 21.6 0.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_33 PF13671.6 CCM01215.1 - 0.00019 21.6 0.2 0.015 15.5 0.0 2.9 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 CCM01215.1 - 0.00029 20.6 0.0 0.022 14.5 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_28 PF13521.6 CCM01215.1 - 0.0006 20.1 0.0 0.098 12.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCM01215.1 - 0.0015 18.3 0.0 0.43 10.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain Viral_helicase1 PF01443.18 CCM01215.1 - 0.0021 17.8 0.0 5.7 6.6 0.0 4.1 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 CCM01215.1 - 0.0026 18.1 0.0 0.38 11.2 0.0 2.5 2 0 0 2 2 2 1 RNA helicase TIP49 PF06068.13 CCM01215.1 - 0.0036 16.6 0.0 0.0093 15.2 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain ATPase PF06745.13 CCM01215.1 - 0.0064 15.9 0.2 0.16 11.3 0.0 2.4 2 0 0 2 2 2 1 KaiC Sigma54_activat PF00158.26 CCM01215.1 - 0.0078 15.9 0.0 0.43 10.3 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 CCM01215.1 - 0.0091 16.0 0.0 0.39 10.7 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_3 PF07726.11 CCM01215.1 - 0.012 15.4 0.0 0.047 13.6 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CCM01215.1 - 0.021 14.4 0.1 0.69 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CCM01215.1 - 0.026 14.5 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CCM01215.1 - 0.031 14.2 0.0 11 5.8 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF2075 PF09848.9 CCM01215.1 - 0.078 12.2 0.1 6.4 5.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.6 CCM01215.1 - 0.091 12.6 0.3 0.36 10.7 0.3 2.1 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain NTPase_1 PF03266.15 CCM01215.1 - 0.099 12.6 0.0 7.9 6.4 0.0 2.6 2 0 0 2 2 2 0 NTPase DUF815 PF05673.13 CCM01215.1 - 0.14 11.3 0.0 0.32 10.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 CCM01215.1 - 0.16 11.0 0.0 0.42 9.7 0.0 1.6 2 0 0 2 2 1 0 Parvovirus non-structural protein NS1 TFIID-18kDa PF02269.16 CCM01215.1 - 0.16 12.0 0.0 18 5.4 0.0 2.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 18kD subunit DivIC PF04977.15 CCM01215.1 - 0.2 11.5 1.2 0.55 10.0 1.2 1.7 1 0 0 1 1 1 0 Septum formation initiator DUF2072 PF09845.9 CCM01215.1 - 0.2 11.9 0.1 0.4 11.0 0.1 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein AAA_23 PF13476.6 CCM01215.1 - 0.45 11.0 2.6 7.8 6.9 0.0 3.2 3 0 0 3 3 2 0 AAA domain Rap1_C PF11626.8 CCM01216.1 - 0.18 11.9 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Peptidase_S10 PF00450.22 CCM01217.1 - 2.6e-92 310.4 4.8 3.2e-92 310.1 4.8 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hira PF07569.11 CCM01218.1 - 2e-59 201.0 0.1 7.7e-59 199.1 0.1 1.9 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 CCM01218.1 - 4.4e-27 93.8 23.5 4.5e-07 30.5 0.1 8.3 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM01218.1 - 1.7e-14 53.9 1.2 0.095 13.0 0.0 6.8 3 1 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCM01218.1 - 0.14 12.1 0.8 75 3.4 0.1 4.2 3 1 1 4 4 4 0 WD40-like Beta Propeller Repeat zf-C2H2_jaz PF12171.8 CCM01219.1 - 8.7e-15 54.6 2.7 0.0019 18.5 0.1 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM01219.1 - 1.7e-12 47.3 2.0 0.0029 18.0 0.1 3.3 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CCM01219.1 - 6.8e-09 35.8 3.0 0.015 16.0 0.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCM01219.1 - 2.7e-06 27.5 5.2 0.056 13.9 0.1 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CCM01219.1 - 6.3e-05 23.2 1.0 0.0001 22.6 1.0 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-RRPl_C4 PF17026.5 CCM01219.1 - 0.00094 19.3 3.1 0.003 17.7 3.1 1.8 1 1 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type HNH_5 PF14279.6 CCM01219.1 - 0.0055 16.5 1.3 0.78 9.7 0.3 3.1 2 1 0 2 2 2 1 HNH endonuclease zf-C2H2_9 PF16293.5 CCM01219.1 - 0.031 14.1 0.9 0.9 9.4 0.0 2.6 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF2256 PF10013.9 CCM01219.1 - 0.048 13.8 3.5 0.63 10.2 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-SNAP50_C PF12251.8 CCM01219.1 - 0.14 11.8 2.3 0.21 11.2 2.3 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal zf-C2HC_2 PF13913.6 CCM01219.1 - 0.17 11.8 4.2 5 7.1 0.3 3.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C3HC4_3 PF13920.6 CCM01219.1 - 1.7 8.6 6.1 5.6 6.9 6.1 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-H2C2_2 PF13465.6 CCM01219.1 - 2.8 8.5 7.6 48 4.6 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double domain FYVE PF01363.21 CCM01219.1 - 3.4 7.9 7.3 1.8 8.7 4.1 2.0 1 1 1 2 2 2 0 FYVE zinc finger zf-CRD PF17979.1 CCM01219.1 - 4 7.5 7.7 3.2 7.8 3.9 2.0 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions DUF4187 PF13821.6 CCM01219.1 - 6.1 6.7 9.1 5.2 6.9 0.2 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4187) zf-C2H2_6 PF13912.6 CCM01219.1 - 9.6 6.3 7.5 3.1 7.9 0.4 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-PARP PF00645.18 CCM01220.1 - 8.6e-45 151.5 5.8 1.8e-23 83.2 1.0 2.9 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Ribosomal_S26e PF01283.19 CCM01222.1 - 1.1e-27 96.6 1.1 1.3e-27 96.3 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e DUF1918 PF08940.11 CCM01222.1 - 0.062 12.9 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) ADH_zinc_N_2 PF13602.6 CCM01223.1 - 7.8e-17 62.6 0.0 1.4e-16 61.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCM01223.1 - 1.2e-11 44.7 0.0 1.9e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM01223.1 - 2.2e-09 37.2 0.1 1.3e-06 28.3 0.0 2.4 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain DAO PF01266.24 CCM01224.1 - 5.4e-31 108.5 4.0 1.1e-30 107.5 4.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM01224.1 - 1.3e-06 27.8 0.1 2e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM01224.1 - 1.6e-05 24.3 0.1 7.2e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM01224.1 - 0.0017 18.5 2.1 0.0039 17.4 1.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCM01224.1 - 0.013 14.8 0.1 0.021 14.1 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 CCM01224.1 - 0.014 14.3 0.9 1.4 7.6 0.8 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 CCM01224.1 - 0.034 12.9 0.2 0.049 12.3 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 CCM01224.1 - 0.074 12.1 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CCM01224.1 - 0.11 11.5 0.1 0.24 10.4 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCM01224.1 - 0.14 11.4 0.4 0.19 10.9 0.4 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Mycobact_memb PF05423.13 CCM01224.1 - 0.16 11.9 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Mycobacterium membrane protein Pyr_redox PF00070.27 CCM01224.1 - 0.46 11.1 2.3 0.81 10.3 2.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HLH PF00010.26 CCM01225.1 - 3.9e-11 42.7 0.2 1.4e-10 41.0 0.0 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Phage_tail_T PF06223.12 CCM01225.1 - 0.16 12.5 0.2 3.2 8.3 0.2 2.6 2 0 0 2 2 2 0 Minor tail protein T AT_hook PF02178.19 CCM01225.1 - 7.2 6.9 10.9 2.1 8.5 7.0 2.4 2 0 0 2 2 2 0 AT hook motif Ysc84 PF04366.12 CCM01226.1 - 5.6e-41 139.3 0.2 9.2e-41 138.6 0.2 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 CCM01226.1 - 3.1e-16 58.7 0.0 7e-16 57.6 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCM01226.1 - 5.4e-14 51.6 0.2 3.4e-13 49.0 0.1 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 CCM01226.1 - 1.6e-12 47.0 0.0 4.3e-12 45.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain DAO PF01266.24 CCM01227.1 - 1.3e-37 130.3 0.1 1.5e-37 130.0 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM01227.1 - 0.004 16.3 0.0 0.0049 16.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Glu_dehyd_C PF16912.5 CCM01227.1 - 0.0066 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 CCM01227.1 - 0.014 14.7 0.0 0.054 12.7 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM01227.1 - 0.036 14.3 1.5 0.087 13.1 0.8 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 CCM01227.1 - 0.092 12.4 0.2 0.22 11.1 0.1 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 CCM01227.1 - 0.14 11.4 0.2 0.26 10.5 0.2 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_7 PF13241.6 CCM01227.1 - 0.15 12.5 0.0 0.25 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 CCM01227.1 - 0.28 11.8 1.9 0.53 10.9 1.9 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NUDIX PF00293.28 CCM01228.1 - 5.5e-11 42.6 0.3 8.5e-11 42.0 0.1 1.4 1 1 0 1 1 1 1 NUDIX domain DUF2046 PF09755.9 CCM01229.1 - 1.9e-11 43.7 4.5 1.9e-11 43.7 4.5 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) HSP20 PF00011.21 CCM01230.1 - 4.3e-05 23.6 0.0 7.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCM01230.1 - 0.0018 17.8 0.0 0.31 10.6 0.0 2.2 2 0 0 2 2 2 2 HSP20-like domain found in ArsA FA_desaturase PF00487.24 CCM01231.1 - 3.8e-24 85.9 13.6 5.9e-24 85.3 13.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 CCM01231.1 - 1.7e-19 69.0 0.3 3e-19 68.2 0.3 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) adh_short_C2 PF13561.6 CCM01233.1 - 5e-58 196.4 2.2 5.6e-58 196.3 2.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM01233.1 - 3e-56 190.0 2.2 3.7e-56 189.7 2.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM01233.1 - 2.6e-10 40.5 1.8 3.6e-10 40.0 1.8 1.2 1 0 0 1 1 1 1 KR domain Transketolase_C PF02780.20 CCM01233.1 - 0.0074 16.2 0.4 0.015 15.2 0.4 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain HHH_5 PF14520.6 CCM01233.1 - 0.061 13.9 0.2 1.3 9.7 0.1 2.7 3 0 0 3 3 3 0 Helix-hairpin-helix domain adh_short_C2 PF13561.6 CCM01234.1 - 8.3e-58 195.7 0.8 9.3e-58 195.5 0.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM01234.1 - 4.7e-54 182.8 0.4 5.8e-54 182.5 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM01234.1 - 1e-08 35.3 2.0 1.5e-08 34.8 2.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM01234.1 - 0.096 12.1 0.1 0.15 11.5 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 CCM01236.1 - 2.7e-52 177.1 1.4 4.1e-46 156.9 1.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01236.1 - 2.2e-47 161.6 1.0 5.7e-33 114.4 0.6 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01236.1 - 3.1e-06 27.2 1.0 4.7e-06 26.6 1.0 1.2 1 0 0 1 1 1 1 KR domain MFS_1 PF07690.16 CCM01237.1 - 5.6e-32 111.0 117.4 2.5e-19 69.5 51.4 3.7 2 2 2 4 4 4 4 Major Facilitator Superfamily TMIE PF16038.5 CCM01237.1 - 0.0016 18.2 0.0 0.18 11.7 0.0 2.4 2 0 0 2 2 2 2 TMIE protein Deltameth_res PF16020.5 CCM01237.1 - 0.3 11.0 2.6 3.8 7.5 0.1 4.1 3 0 0 3 3 3 0 Deltamethrin resistance p450 PF00067.22 CCM01238.1 - 9.7e-76 255.4 0.0 1.7e-75 254.5 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Ferric_reduct PF01794.19 CCM01239.1 - 3.7e-19 69.1 7.3 3.7e-19 69.1 7.3 1.7 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCM01239.1 - 9e-13 48.3 0.0 1.7e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CCM01239.1 - 1.2e-08 35.2 0.0 1.6e-06 28.3 0.0 2.5 2 1 0 2 2 2 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 CCM01239.1 - 0.016 15.8 0.1 0.042 14.5 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain WTF PF03303.13 CCM01239.1 - 0.055 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 WTF protein F-box-like PF12937.7 CCM01240.1 - 0.00021 21.1 0.1 0.0005 19.9 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01240.1 - 0.01 15.7 0.1 0.01 15.7 0.1 2.5 4 0 0 4 4 4 0 F-box domain Pkinase PF00069.25 CCM01241.1 - 6.2e-50 170.0 0.0 4.8e-49 167.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01241.1 - 3.1e-20 72.5 0.0 6.1e-11 42.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCM01241.1 - 7.5e-12 45.1 0.0 0.00046 19.6 0.0 3.1 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 CCM01241.1 - 0.00019 20.5 0.0 0.00028 20.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 CCM01241.1 - 0.0054 15.6 0.0 0.011 14.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase PIP49_C PF12260.8 CCM01241.1 - 0.16 11.6 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 APH PF01636.23 CCM01241.1 - 0.36 10.7 2.6 0.65 9.9 1.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Glyco_hydro_cc PF11790.8 CCM01243.1 - 1.8e-62 211.0 7.0 2.2e-62 210.8 7.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Cellulase PF00150.18 CCM01243.1 - 0.00052 19.5 2.5 0.4 10.1 0.1 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) DUF4598 PF15370.6 CCM01244.1 - 1.4e-11 44.8 2.2 4.2e-11 43.3 2.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4598) AF-4 PF05110.13 CCM01244.1 - 0.24 9.5 10.6 0.26 9.3 10.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein EPSP_synthase PF00275.20 CCM01245.1 - 4.7e-121 404.4 0.0 8.5e-121 403.5 0.0 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 CCM01245.1 - 2.3e-101 338.4 0.1 5.2e-101 337.2 0.0 1.6 2 0 0 2 2 2 1 3-dehydroquinate synthase DHquinase_I PF01487.15 CCM01245.1 - 4.1e-54 184.2 0.0 6.9e-54 183.5 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 CCM01245.1 - 1.4e-31 109.8 0.0 4.6e-31 108.1 0.0 1.8 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 CCM01245.1 - 1.2e-26 92.7 0.0 4.8e-26 90.8 0.0 2.1 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 CCM01245.1 - 6.9e-08 32.1 0.5 4.1e-07 29.6 0.0 2.6 3 0 0 3 3 3 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 CCM01245.1 - 2e-07 31.0 0.0 4.4e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.20 CCM01245.1 - 4.4e-05 23.6 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_33 PF13671.6 CCM01245.1 - 0.0093 16.1 0.0 0.071 13.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Asparaginase_C PF17763.1 CCM01245.1 - 0.047 13.9 0.2 0.25 11.6 0.0 2.3 3 0 0 3 3 3 0 Glutaminase/Asparaginase C-terminal domain Sacchrp_dh_NADP PF03435.18 CCM01245.1 - 0.13 12.5 0.1 16 5.7 0.0 3.4 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 CCM01246.1 - 1.6e-53 181.8 0.0 2e-53 181.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM01246.1 - 2.2e-10 41.0 0.0 1.2e-08 35.4 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCM01246.1 - 0.014 15.8 0.2 0.22 12.0 0.0 2.7 3 0 0 3 3 3 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 CCM01246.1 - 0.14 11.4 0.5 5 6.3 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ADH_N PF08240.12 CCM01247.1 - 9.5e-28 96.3 1.5 1.5e-27 95.6 1.5 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM01247.1 - 4.1e-20 72.1 0.1 7.6e-20 71.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM01247.1 - 0.018 16.1 0.0 0.038 15.1 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GCP_N_terminal PF17681.1 CCM01248.1 - 2.1e-65 221.4 0.0 4.4e-65 220.3 0.0 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCM01248.1 - 3.7e-60 204.0 9.2 3.7e-60 204.0 9.2 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal S4 PF01479.25 CCM01249.1 - 5.1e-11 42.1 0.0 9e-11 41.3 0.0 1.4 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CCM01249.1 - 0.015 15.1 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 S4 domain ICMT PF04140.14 CCM01250.1 - 2.4e-12 47.1 0.9 7.3e-12 45.5 0.0 2.2 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM01250.1 - 6.7e-08 32.9 0.7 1.6e-07 31.7 0.2 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCM01250.1 - 0.00042 19.2 0.0 0.00075 18.4 0.0 1.4 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family UBX PF00789.20 CCM01252.1 - 6.1e-10 39.2 0.0 1.2e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 CCM01252.1 - 1.1e-07 31.5 0.0 2.4e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain DUF1682 PF07946.14 CCM01252.1 - 0.11 11.7 6.1 0.17 11.1 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CUE PF02845.16 CCM01253.1 - 4e-11 42.4 0.3 7.3e-11 41.6 0.0 1.6 2 0 0 2 2 2 1 CUE domain ODV-E18 PF10717.9 CCM01253.1 - 0.018 14.9 0.2 0.039 13.8 0.2 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Prenylcys_lyase PF07156.14 CCM01254.1 - 8.7e-68 229.0 0.0 1.2e-67 228.6 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 CCM01254.1 - 5.5e-10 39.3 0.0 1.1e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CCM01254.1 - 7e-09 35.5 0.0 2.9e-08 33.4 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 CCM01254.1 - 1.7e-05 24.6 0.7 0.00013 21.7 0.7 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCM01254.1 - 0.005 16.8 0.0 0.015 15.3 0.0 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CCM01254.1 - 0.025 13.8 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM01254.1 - 0.18 11.0 0.1 0.31 10.2 0.1 1.3 1 0 0 1 1 1 0 Thi4 family SPT_ssu-like PF11779.8 CCM01255.1 - 7.8e-13 47.8 5.4 1.3e-12 47.1 5.4 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Epiglycanin_C PF14654.6 CCM01255.1 - 0.24 11.5 2.8 0.39 10.8 2.8 1.3 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region SPT_ssu-like PF11779.8 CCM01256.1 - 6.8e-13 48.0 3.9 1.2e-12 47.2 3.9 1.4 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like NAT PF04768.13 CCM01257.1 - 6.1e-46 156.2 0.0 9.7e-46 155.5 0.0 1.3 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 CCM01257.1 - 1.5e-25 90.0 0.0 5.5e-25 88.1 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 CCM01257.1 - 1.3e-24 87.1 0.0 2.5e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dhC PF02774.18 CCM01257.1 - 0.00042 20.4 0.0 0.00071 19.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Skp1_POZ PF03931.15 CCM01258.1 - 7.3e-05 22.9 0.0 0.00013 22.0 0.0 1.4 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain Imm59 PF15597.6 CCM01258.1 - 0.055 13.9 0.0 0.078 13.5 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 59 SCF PF02404.15 CCM01258.1 - 0.061 12.7 0.0 0.07 12.5 0.0 1.1 1 0 0 1 1 1 0 Stem cell factor Myosin_head PF00063.21 CCM01260.1 - 2.6e-258 858.8 0.0 3.7e-257 854.9 0.0 2.9 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 CCM01260.1 - 2.1e-27 95.4 294.2 1.8e-14 52.6 148.0 7.3 2 2 3 6 6 6 6 Myosin tail Myosin_N PF02736.19 CCM01260.1 - 7e-10 38.6 1.9 7e-10 38.6 1.9 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 CCM01260.1 - 0.028 14.7 0.0 0.028 14.7 0.0 6.6 6 2 2 8 8 8 0 AAA domain Hydrolase_4 PF12146.8 CCM01261.1 - 2.4e-13 49.9 0.0 5.8e-11 42.1 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCM01261.1 - 1.4e-12 47.9 0.2 4.3e-11 42.9 0.1 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM01261.1 - 2.5e-06 28.2 0.1 4.2e-06 27.5 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 CCM01261.1 - 3.4e-05 23.9 0.0 0.0018 18.2 0.0 2.2 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 CCM01261.1 - 4.3e-05 23.4 0.0 0.057 13.2 0.0 2.9 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase AXE1 PF05448.12 CCM01261.1 - 0.00019 20.2 0.2 0.016 13.9 0.0 2.2 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 CCM01261.1 - 0.011 15.4 0.0 0.67 9.5 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CCM01261.1 - 0.011 15.2 0.0 0.52 9.8 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family FSH1 PF03959.13 CCM01261.1 - 0.11 12.1 0.0 0.37 10.4 0.0 1.8 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Metallophos PF00149.28 CCM01263.1 - 1.7e-35 123.4 0.1 3.3e-35 122.5 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ADH_zinc_N PF00107.26 CCM01264.1 - 3.4e-27 95.0 0.7 1.5e-26 92.9 0.3 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM01264.1 - 7.3e-09 35.5 0.1 2.3e-08 33.9 0.1 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCM01264.1 - 3.7e-06 28.0 0.0 6.9e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF3868 PF12984.7 CCM01264.1 - 0.0074 16.1 0.3 0.021 14.6 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function, B. Theta Gene description (DUF3868) AlaDh_PNT_C PF01262.21 CCM01264.1 - 0.023 14.0 0.1 0.038 13.3 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pescadillo_N PF06732.11 CCM01264.1 - 0.13 11.8 0.2 0.19 11.2 0.2 1.1 1 0 0 1 1 1 0 Pescadillo N-terminus NAD_binding_7 PF13241.6 CCM01264.1 - 0.18 12.3 0.1 0.31 11.5 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding EF-hand_7 PF13499.6 CCM01265.1 - 3.5e-11 43.4 0.0 2.8e-06 27.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCM01265.1 - 6.6e-11 41.2 0.5 0.00015 21.4 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CCM01265.1 - 6.7e-09 34.7 0.1 0.00037 19.8 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 CCM01265.1 - 2.8e-06 27.5 0.0 0.034 14.5 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CCM01265.1 - 6.4e-05 22.7 0.0 0.00065 19.5 0.0 2.5 2 2 1 3 3 3 1 EF-hand domain pair SapB_1 PF05184.15 CCM01265.1 - 0.012 15.6 0.0 3.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 1 EF-hand_11 PF08976.11 CCM01265.1 - 0.02 15.8 0.0 0.045 14.6 0.0 1.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 CCM01265.1 - 0.03 13.8 0.1 0.67 9.6 0.0 2.5 2 0 0 2 2 2 0 EF hand DDE_Tnp_IS66_C PF13817.6 CCM01265.1 - 0.2 11.9 0.1 0.47 10.7 0.1 1.6 1 0 0 1 1 1 0 IS66 C-terminal element zf-C2HC_2 PF13913.6 CCM01266.1 - 0.00064 19.5 6.5 0.0037 17.1 1.7 2.7 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 CCM01266.1 - 0.0028 18.4 8.1 0.037 14.9 2.4 3.4 3 0 0 3 3 3 1 C2H2-type zinc finger zf-Di19 PF05605.12 CCM01266.1 - 0.0051 17.1 4.3 0.03 14.6 0.5 2.5 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CCM01266.1 - 0.0082 16.5 1.3 0.017 15.5 1.3 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 CCM01266.1 - 0.042 14.3 0.3 0.042 14.3 0.3 2.1 2 0 0 2 2 1 0 Zinc-finger double domain zf-C2H2 PF00096.26 CCM01266.1 - 0.043 14.3 10.2 0.16 12.5 2.7 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF629 PF04780.12 CCM01266.1 - 0.075 11.5 2.9 0.12 10.9 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) IBR PF01485.21 CCM01266.1 - 0.1 12.9 1.9 0.36 11.1 1.9 1.8 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Rad50_zn_hook PF04423.14 CCM01266.1 - 0.12 12.2 1.0 0.23 11.3 0.7 1.6 1 1 0 1 1 1 0 Rad50 zinc hook motif Zn-C2H2_12 PF18112.1 CCM01266.1 - 0.57 10.7 3.5 0.81 10.2 0.3 2.8 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zinc_ribbon_9 PF14369.6 CCM01266.1 - 5.2 7.4 6.2 25 5.2 0.0 3.7 4 0 0 4 4 4 0 zinc-ribbon UQ_con PF00179.26 CCM01267.1 - 1.7e-48 163.8 0.0 1.9e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCM01267.1 - 0.00043 20.0 0.0 0.00054 19.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CCM01267.1 - 0.017 15.0 0.1 0.033 14.1 0.1 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 CCM01267.1 - 0.11 12.8 0.2 0.18 12.1 0.2 1.4 1 1 0 1 1 1 0 RWD domain p450 PF00067.22 CCM01268.1 - 5e-71 239.8 0.0 6.3e-71 239.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Srg PF02118.21 CCM01268.1 - 0.00049 19.9 5.9 0.00078 19.2 5.9 1.2 1 0 0 1 1 1 1 Srg family chemoreceptor UbiA PF01040.18 CCM01270.1 - 1.8e-39 135.5 17.3 2.2e-39 135.2 17.3 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family F-box-like PF12937.7 CCM01271.1 - 0.0014 18.4 0.1 0.0045 16.8 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01271.1 - 0.032 14.1 0.3 0.28 11.1 0.1 2.6 2 0 0 2 2 2 0 F-box domain DPPIV_N PF00930.21 CCM01272.1 - 9.3e-93 310.8 0.3 1.2e-92 310.4 0.3 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CCM01272.1 - 5.2e-47 160.1 2.4 8.2e-47 159.4 2.4 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CCM01272.1 - 1.2e-05 25.0 0.2 2.4e-05 24.1 0.2 1.5 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 CCM01272.1 - 0.00034 20.4 0.2 0.0006 19.5 0.2 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM01272.1 - 0.006 17.2 1.0 0.018 15.6 0.1 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family PD40 PF07676.12 CCM01272.1 - 0.0082 16.1 2.6 2.3 8.2 0.7 2.8 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat AXE1 PF05448.12 CCM01272.1 - 0.033 12.9 0.0 0.076 11.7 0.0 1.5 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) DLH PF01738.18 CCM01272.1 - 0.21 11.1 0.2 0.94 9.0 0.2 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family SYS1 PF09801.9 CCM01273.1 - 2.2e-26 92.7 2.3 3.7e-19 69.3 1.2 2.1 2 0 0 2 2 2 2 Integral membrane protein S linking to the trans Golgi network BCS1_N PF08740.11 CCM01274.1 - 2.5e-44 151.5 2.9 2.5e-44 151.5 2.9 2.7 2 1 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 CCM01274.1 - 9.3e-11 42.3 0.0 2.5e-09 37.7 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BUD22 PF09073.10 CCM01274.1 - 0.054 12.8 37.2 0.11 11.9 37.2 1.5 1 0 0 1 1 1 0 BUD22 YlbE PF14003.6 CCM01274.1 - 0.066 13.7 0.1 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 YlbE-like protein TAF4 PF05236.14 CCM01274.1 - 0.2 11.4 22.6 0.37 10.5 22.6 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family XRN_M PF17846.1 CCM01274.1 - 1 8.2 15.5 2 7.3 15.5 1.5 1 0 0 1 1 1 0 Xrn1 helical domain Hamartin PF04388.12 CCM01274.1 - 1.2 7.7 23.9 1.8 7.2 23.9 1.1 1 0 0 1 1 1 0 Hamartin protein LAP1C PF05609.12 CCM01274.1 - 4.8 6.2 27.4 7.8 5.5 27.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dynamin_M PF01031.20 CCM01275.1 - 8.7e-94 313.9 0.0 2.6e-93 312.4 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 CCM01275.1 - 4.1e-54 183.1 0.0 7e-54 182.4 0.0 1.4 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CCM01275.1 - 2.4e-30 104.5 2.3 1.4e-29 102.1 1.2 2.3 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCM01275.1 - 6.6e-05 23.0 0.1 0.00047 20.2 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Mt_ATP-synt_B PF05405.14 CCM01276.1 - 4.2e-44 150.0 10.4 5.1e-44 149.8 10.4 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF5623 PF18536.1 CCM01276.1 - 0.013 15.8 0.9 0.027 14.8 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5623) SLATT_1 PF18181.1 CCM01276.1 - 0.23 11.4 3.8 0.55 10.2 3.2 1.9 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DUF5127 PF17168.4 CCM01277.1 - 3.4e-63 213.5 2.9 4.6e-63 213.1 2.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CCM01277.1 - 4.9e-21 75.1 0.4 4.5e-20 72.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4965) CS PF04969.16 CCM01278.1 - 6.3e-06 27.1 0.0 1.2e-05 26.2 0.0 1.5 1 0 0 1 1 1 1 CS domain Sporozoite_P67 PF05642.11 CCM01278.1 - 0.057 11.5 0.1 0.054 11.6 0.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MFS18 PF17352.2 CCM01278.1 - 0.56 10.6 14.7 1.1 9.7 14.7 1.5 1 0 0 1 1 1 0 Male Flower Specific protein 18 ATP11 PF06644.11 CCM01280.1 - 1.6e-72 244.6 0.0 1.9e-72 244.3 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein WD40 PF00400.32 CCM01281.1 - 1.2e-31 108.3 7.8 1.3e-05 25.8 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 CCM01281.1 - 3e-06 26.2 0.1 0.0051 15.5 0.0 3.5 4 0 0 4 4 4 2 Nucleoporin Nup120/160 AlphaC_C PF17480.2 CCM01281.1 - 0.1 12.6 0.4 0.24 11.4 0.4 1.5 1 0 0 1 1 1 0 AlphaC C-terminal EzrA PF06160.12 CCM01281.1 - 0.32 9.1 5.4 0.45 8.6 5.4 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA CTNNBL PF08216.11 CCM01281.1 - 0.41 10.9 2.4 0.76 10.0 2.4 1.4 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear CENP-F_leu_zip PF10473.9 CCM01281.1 - 0.49 10.4 10.2 0.91 9.5 10.2 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Macoilin PF09726.9 CCM01281.1 - 0.87 8.1 3.6 1.3 7.5 3.6 1.2 1 0 0 1 1 1 0 Macoilin family PseudoU_synth_2 PF00849.22 CCM01282.1 - 4.4e-27 95.1 0.0 7.5e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ub-Mut7C PF14451.6 CCM01282.1 - 0.12 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Mut7-C ubiquitin DUF4523 PF15023.6 CCM01283.1 - 0.044 13.6 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Tegument_dsDNA PF12818.7 CCM01283.1 - 0.18 10.9 0.0 0.19 10.9 0.0 1.0 1 0 0 1 1 1 0 dsDNA viral tegument protein FAD_binding_3 PF01494.19 CCM01284.1 - 1.2e-76 258.2 0.0 1.6e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM01284.1 - 2.5e-06 26.9 0.1 0.0001 21.7 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM01284.1 - 6.1e-06 26.4 0.1 2.4e-05 24.5 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCM01284.1 - 2.7e-05 23.1 0.4 0.00067 18.5 0.0 2.5 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_2 PF00890.24 CCM01284.1 - 4.7e-05 22.6 0.8 9.5e-05 21.6 0.3 1.7 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 CCM01284.1 - 9.9e-05 21.7 0.3 0.00081 18.7 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CCM01284.1 - 0.00016 22.2 0.0 0.0058 17.2 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM01284.1 - 0.00058 19.6 1.2 0.0033 17.1 0.3 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CCM01284.1 - 0.00082 18.7 0.1 0.0016 17.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCM01284.1 - 0.0087 15.2 0.1 0.018 14.1 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 CCM01284.1 - 0.027 13.6 0.1 0.045 12.8 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 CCM01284.1 - 0.032 13.1 0.0 0.045 12.6 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CCM01284.1 - 0.032 14.2 0.2 0.074 13.0 0.2 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 CCM01284.1 - 0.034 13.5 0.4 0.059 12.7 0.4 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.23 CCM01284.1 - 0.17 11.8 0.1 0.97 9.4 0.0 2.0 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 CCM01285.1 - 1.4e-76 258.1 0.0 1.8e-76 257.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CCM01285.1 - 1.7e-06 27.4 0.7 0.0022 17.1 0.1 2.6 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_2 PF07992.14 CCM01285.1 - 2.2e-06 27.1 0.5 0.0019 17.5 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM01285.1 - 0.00037 21.0 0.0 2 9.1 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM01285.1 - 0.00063 19.1 0.1 0.0017 17.7 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM01285.1 - 0.0014 18.3 0.2 0.15 11.6 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCM01285.1 - 0.0021 17.3 0.1 0.0084 15.4 0.0 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCM01285.1 - 0.004 17.4 0.2 0.01 16.1 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCM01285.1 - 0.014 14.1 0.1 1.4 7.6 0.0 2.3 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 CCM01286.1 - 4.5e-80 269.5 0.0 5.6e-80 269.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM01286.1 - 3.7e-07 29.7 2.0 0.00026 20.3 0.1 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM01286.1 - 2e-06 27.1 0.4 0.00019 20.7 0.2 2.3 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CCM01286.1 - 4.4e-06 27.2 0.1 0.043 14.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM01286.1 - 0.0002 21.5 0.2 0.0006 20.0 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCM01286.1 - 0.00025 20.4 0.1 0.00099 18.4 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM01286.1 - 0.00029 19.7 0.4 0.031 13.0 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.17 CCM01286.1 - 0.00029 20.1 0.0 0.00077 18.8 0.0 1.6 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCM01286.1 - 0.00092 18.9 0.2 0.012 15.2 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.23 CCM01286.1 - 0.019 14.9 0.0 0.35 10.8 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_7 PF13241.6 CCM01286.1 - 0.068 13.6 0.0 0.22 12.0 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 CCM01286.1 - 0.1 12.0 0.3 0.55 9.5 0.1 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM01286.1 - 0.17 10.9 0.1 0.35 9.9 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 CCM01287.1 - 2.1e-60 204.8 0.0 8.3e-60 202.9 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM01287.1 - 6.6e-05 22.3 0.4 0.00027 20.3 0.1 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM01287.1 - 7.3e-05 23.3 0.0 0.061 13.9 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM01287.1 - 0.00015 21.0 0.2 0.00023 20.4 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CCM01287.1 - 0.00025 20.4 0.0 0.00046 19.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CCM01287.1 - 0.00029 21.0 0.2 0.00098 19.3 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCM01287.1 - 0.00075 18.8 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM01287.1 - 0.0069 16.0 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCM01287.1 - 0.019 13.7 0.0 0.049 12.3 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_7 PF13241.6 CCM01287.1 - 0.089 13.2 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 CCM01287.1 - 0.15 12.0 0.0 0.42 10.6 0.0 1.7 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 CCM01288.1 - 3.5e-71 240.3 0.0 5.2e-71 239.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM01288.1 - 5.1e-07 29.2 1.8 0.00016 21.0 0.1 3.2 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM01288.1 - 1.4e-05 25.6 0.9 0.012 16.1 0.1 2.9 4 0 0 4 4 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM01288.1 - 8.7e-05 22.7 0.1 0.00023 21.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM01288.1 - 0.00014 21.6 0.7 0.0057 16.3 0.1 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM01288.1 - 0.00036 19.7 2.8 0.001 18.2 0.3 2.4 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 CCM01288.1 - 0.00047 19.5 0.6 0.001 18.4 0.0 1.8 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 CCM01288.1 - 0.003 16.3 0.4 0.042 12.5 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Trp_halogenase PF04820.14 CCM01288.1 - 0.012 14.5 0.2 0.028 13.3 0.1 1.7 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 CCM01288.1 - 0.019 14.1 0.4 0.096 11.7 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 CCM01288.1 - 0.031 14.5 0.1 0.17 12.1 0.2 2.2 2 0 0 2 2 2 0 TrkA-N domain Pyr_redox_3 PF13738.6 CCM01288.1 - 0.034 13.4 0.1 0.07 12.4 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCM01288.1 - 0.048 13.7 0.1 0.089 12.8 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 CCM01288.1 - 0.079 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ERbeta_N PF12497.8 CCM01288.1 - 0.15 11.8 0.1 0.28 11.0 0.1 1.3 1 0 0 1 1 1 0 Estrogen receptor beta HAUS-augmin3 PF14932.6 CCM01289.1 - 0.016 14.8 0.3 0.023 14.3 0.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 HWE_HK PF07536.14 CCM01289.1 - 0.061 14.0 4.4 4.3 8.1 0.3 2.5 1 1 1 2 2 2 0 HWE histidine kinase GvpK PF05121.12 CCM01289.1 - 7.2 6.7 9.1 0.72 9.9 1.4 2.9 2 1 1 3 3 3 0 Gas vesicle protein K STE3 PF02076.15 CCM01290.1 - 2.7e-93 312.4 24.3 3.2e-93 312.1 24.3 1.0 1 0 0 1 1 1 1 Pheromone A receptor DUF2214 PF09980.9 CCM01290.1 - 0.2 11.4 2.5 0.62 9.9 2.5 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2214) NAD_binding_10 PF13460.6 CCM01291.1 - 4.9e-32 111.3 0.1 5.7e-32 111.1 0.1 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCM01291.1 - 2.1e-08 34.0 0.0 3.3e-08 33.4 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCM01291.1 - 2.3e-08 33.8 0.0 3.7e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCM01291.1 - 0.00028 21.3 0.0 0.00047 20.6 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCM01291.1 - 0.0053 15.8 0.0 0.01 14.9 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 CCM01291.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.7 2 1 0 2 2 2 0 TrkA-N domain Cellulase PF00150.18 CCM01292.1 - 2.4e-17 63.3 0.2 3.2e-17 62.9 0.2 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) BPL_LplA_LipB PF03099.19 CCM01294.1 - 2.3e-07 30.8 0.0 5.4e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Thiolase_N PF00108.23 CCM01295.1 - 4.3e-13 49.2 0.0 3.8e-11 42.9 0.0 2.5 2 1 1 3 3 3 2 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 CCM01295.1 - 3.9e-06 26.6 0.7 0.0056 16.3 0.3 2.7 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Thiolase_C PF02803.18 CCM01295.1 - 9.6e-06 25.3 0.0 0.00015 21.4 0.0 2.4 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 CCM01295.1 - 0.0007 19.4 0.0 0.026 14.4 0.0 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Alanine_zipper PF11839.8 CCM01298.1 - 0.73 10.2 10.7 0.094 13.1 2.6 2.3 2 1 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein YtxH PF12732.7 CCM01298.1 - 1.1 9.8 7.2 3.6 8.2 7.1 1.8 1 1 0 1 1 1 0 YtxH-like protein p450 PF00067.22 CCM01299.1 - 1.5e-56 192.1 0.0 1.9e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Utp12 PF04003.12 CCM01300.1 - 3.6e-26 91.6 0.1 5.3e-26 91.0 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family UTP15_C PF09384.10 CCM01300.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 UTP15 C terminal VARLMGL PF14383.6 CCM01300.1 - 0.077 12.5 0.3 3.1 7.4 0.1 2.9 2 0 0 2 2 2 0 DUF761-associated sequence motif TFIIA PF03153.13 CCM01300.1 - 3.6 7.5 24.7 2.3 8.1 19.0 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 CCM01302.1 - 7.6e-75 251.7 0.0 1.3e-74 250.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01302.1 - 6.6e-34 117.4 0.0 1.3e-33 116.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCM01302.1 - 0.00032 19.7 0.0 0.0055 15.7 0.0 2.2 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCM01302.1 - 0.00084 18.7 4.2 0.045 13.1 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCM01302.1 - 0.15 12.0 0.0 0.15 12.0 0.0 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family OAD_gamma PF04277.13 CCM01302.1 - 1.7 9.3 4.6 3.1 8.4 4.6 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Ndc1_Nup PF09531.10 CCM01302.1 - 7.8 5.1 7.8 11 4.6 7.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HATPase_c PF02518.26 CCM01303.1 - 6.7e-26 91.0 0.1 1.3e-25 90.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Fapy_DNA_glyco PF01149.24 CCM01303.1 - 3e-21 76.2 0.1 1e-20 74.5 0.1 1.9 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain HisKA PF00512.25 CCM01303.1 - 3.4e-15 55.8 0.1 3.1e-14 52.7 0.0 2.7 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.6 CCM01303.1 - 9.9e-13 48.8 4.6 9.7e-12 45.6 0.8 3.3 3 0 0 3 3 3 1 AAA ATPase domain Pkinase PF00069.25 CCM01303.1 - 1.3e-07 31.3 0.0 2.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01303.1 - 1.4e-06 27.8 0.0 2.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase H2TH PF06831.14 CCM01303.1 - 3.8e-06 26.8 0.0 1.3e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain DUF3369 PF11849.8 CCM01303.1 - 2.7e-05 24.4 0.1 0.00016 21.9 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3369) Response_reg PF00072.24 CCM01303.1 - 0.00029 21.0 0.1 0.0028 17.8 0.1 2.4 2 0 0 2 2 2 1 Response regulator receiver domain GAF_2 PF13185.6 CCM01303.1 - 0.0036 17.6 0.1 0.57 10.5 0.0 3.2 2 1 0 2 2 1 1 GAF domain HATPase_c_3 PF13589.6 CCM01303.1 - 0.04 13.8 0.0 0.098 12.5 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pim PF16765.5 CCM01303.1 - 0.12 12.6 0.0 0.36 11.0 0.0 1.8 1 0 0 1 1 1 0 Pesticin immunity protein DUF815 PF05673.13 CCM01303.1 - 0.12 11.5 0.0 0.26 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TPR_12 PF13424.6 CCM01303.1 - 6.4 7.2 6.3 5.7 7.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DEAD PF00270.29 CCM01304.1 - 4.6e-37 127.5 0.1 8.8e-37 126.6 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM01304.1 - 6.8e-27 94.0 0.0 4.4e-25 88.2 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM01304.1 - 3.4e-09 36.9 0.0 5.6e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mito_carr PF00153.27 CCM01305.1 - 4e-52 174.1 0.6 1.4e-20 73.0 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein DEAD PF00270.29 CCM01305.1 - 6.3e-38 130.3 0.0 1.1e-37 129.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM01305.1 - 3.5e-25 88.5 0.0 8.9e-25 87.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM01305.1 - 6.6e-06 26.2 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCM01305.1 - 0.96 9.7 3.2 9.8 6.5 3.2 2.3 1 1 0 1 1 1 0 AAA domain HMG_box PF00505.19 CCM01306.1 - 1.5e-13 51.0 0.4 2.7e-13 50.1 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM01306.1 - 8e-07 29.6 0.0 1.9e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain PolyA_pol PF01743.20 CCM01307.1 - 3.6e-25 88.8 0.0 5.7e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CCM01307.1 - 1.3e-06 28.0 0.0 3e-06 26.9 0.0 1.7 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 CCM01307.1 - 0.03 14.3 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Arm PF00514.23 CCM01308.1 - 3.6e-71 233.2 33.2 4.9e-13 48.6 0.1 11.6 11 1 1 12 12 12 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CCM01308.1 - 6.3e-19 68.1 13.7 0.00094 19.6 0.3 7.6 6 2 2 8 8 8 5 HEAT-like repeat HEAT_2 PF13646.6 CCM01308.1 - 1.1e-17 64.1 8.7 0.0005 20.4 0.2 7.0 4 3 2 6 6 6 3 HEAT repeats HEAT PF02985.22 CCM01308.1 - 5.8e-14 51.0 15.8 0.19 12.1 0.0 9.1 9 0 0 9 9 9 5 HEAT repeat Arm_2 PF04826.13 CCM01308.1 - 1.1e-11 44.7 12.7 2.2e-07 30.6 2.7 2.4 1 1 1 2 2 2 2 Armadillo-like Adaptin_N PF01602.20 CCM01308.1 - 1.5e-10 40.3 13.2 2.2e-08 33.1 0.2 2.4 2 1 1 3 3 3 2 Adaptin N terminal region KAP PF05804.12 CCM01308.1 - 1.8e-08 33.0 4.7 2.8e-08 32.4 4.7 1.2 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 CCM01308.1 - 1.1e-07 31.5 11.7 0.0095 15.3 0.3 4.5 2 1 2 4 4 4 3 V-ATPase subunit H Cnd1 PF12717.7 CCM01308.1 - 3e-06 27.4 9.3 0.039 14.0 0.1 5.0 2 2 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 CCM01308.1 - 0.0006 19.8 9.0 1.4 8.9 0.0 4.1 1 1 1 3 3 3 3 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 CCM01308.1 - 0.002 18.2 7.2 25 5.0 0.2 5.2 1 1 3 5 5 5 0 V-ATPase subunit H Vac14_Fab1_bd PF12755.7 CCM01308.1 - 0.007 16.9 0.1 1.2 9.8 0.1 3.2 3 1 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_PBS PF03130.16 CCM01308.1 - 0.051 14.3 14.6 12 6.9 0.4 7.6 9 0 0 9 9 7 0 PBS lyase HEAT-like repeat Atx10homo_assoc PF09759.9 CCM01308.1 - 0.37 10.8 5.2 0.49 10.4 0.1 3.5 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Glyco_hydro_16 PF00722.21 CCM01309.1 - 9.7e-06 25.2 0.1 3.5e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 SprT-like PF10263.9 CCM01310.1 - 2.4e-30 104.7 0.3 4e-30 104.0 0.3 1.3 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 CCM01310.1 - 0.0032 17.3 4.2 0.0032 17.3 4.2 1.8 2 0 0 2 2 2 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 CCM01310.1 - 0.24 11.5 4.7 0.33 11.1 3.3 2.0 2 0 0 2 2 2 0 Zinc ribbon domain Ribosomal_S14 PF00253.21 CCM01311.1 - 2e-14 53.0 3.7 2.2e-14 52.9 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Glyco_hydro_16 PF00722.21 CCM01312.1 - 4.3e-06 26.3 0.0 1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Acatn PF13000.7 CCM01313.1 - 2.5e-101 339.9 25.4 7.4e-71 239.3 13.6 3.4 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 DoxX_2 PF13564.6 CCM01313.1 - 0.64 10.2 0.0 0.64 10.2 0.0 2.8 3 0 0 3 3 3 0 DoxX-like family GYF PF02213.16 CCM01314.1 - 2.2e-16 59.2 0.4 5e-16 58.1 0.4 1.7 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 CCM01314.1 - 0.05 13.4 0.3 0.18 11.6 0.3 2.0 1 0 0 1 1 1 0 GYF domain 2 Atg14 PF10186.9 CCM01316.1 - 1.3e-10 40.8 0.0 2.7e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DNA_pol_viral_N PF00242.17 CCM01316.1 - 0.31 10.5 5.9 0.65 9.4 5.9 1.4 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain PUF PF00806.19 CCM01317.1 - 1.9e-55 181.5 10.5 1.5e-07 30.7 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat cwf21 PF08312.12 CCM01317.1 - 0.12 12.6 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 cwf21 domain 7tm_7 PF08395.12 CCM01317.1 - 0.12 11.5 2.9 3.7 6.7 1.3 2.1 2 0 0 2 2 2 0 7tm Chemosensory receptor Pkinase PF00069.25 CCM01318.1 - 3.7e-70 236.3 0.0 3.5e-68 229.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01318.1 - 5.8e-37 127.4 0.0 6.6e-33 114.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM01318.1 - 2.2e-06 26.7 0.0 3.4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCM01318.1 - 0.00093 19.2 0.0 0.0049 16.8 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCM01318.1 - 0.0011 18.3 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCM01318.1 - 0.0017 17.8 0.3 0.0033 16.8 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 CCM01318.1 - 0.03 13.9 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL ICMT PF04140.14 CCM01320.1 - 1.5e-05 25.3 0.0 3.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM01320.1 - 0.017 15.5 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Phospholipid methyltransferase Bromodomain PF00439.25 CCM01322.1 - 3.8e-21 75.0 0.4 9.8e-21 73.6 0.4 1.8 1 0 0 1 1 1 1 Bromodomain EPL1 PF10513.9 CCM01322.1 - 8.3e-20 71.8 0.4 4e-19 69.5 0.4 2.2 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-HC5HC2H_2 PF13832.6 CCM01322.1 - 2.8e-16 59.6 0.6 5.3e-14 52.3 0.0 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain PHD_2 PF13831.6 CCM01322.1 - 1.9e-15 56.1 2.6 3.6e-15 55.2 2.6 1.5 1 0 0 1 1 1 1 PHD-finger PWWP PF00855.17 CCM01322.1 - 1.6e-14 54.0 0.2 4.6e-14 52.6 0.2 1.8 1 0 0 1 1 1 1 PWWP domain PHD PF00628.29 CCM01322.1 - 1.8e-10 40.5 7.0 2.3e-10 40.2 5.7 1.9 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 CCM01322.1 - 4e-05 23.8 2.2 0.006 16.8 0.0 2.9 3 0 0 3 3 3 1 PHD-like zinc-binding domain zf-PHD-like PF15446.6 CCM01322.1 - 0.0014 18.3 0.8 0.0028 17.3 0.8 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 CCM01322.1 - 0.006 16.5 0.6 0.015 15.2 0.6 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.16 CCM01322.1 - 0.066 13.4 1.6 0.12 12.6 0.5 2.0 2 0 0 2 2 1 0 FYVE-type zinc finger NapB PF03892.14 CCM01322.1 - 0.08 13.0 0.2 0.22 11.5 0.2 1.7 1 0 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) Prok-RING_1 PF14446.6 CCM01322.1 - 0.1 12.5 3.5 0.27 11.2 3.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_9 PF13901.6 CCM01322.1 - 0.14 12.1 8.0 1.4 8.9 0.3 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon C1_2 PF03107.16 CCM01322.1 - 0.34 11.2 3.2 0.3 11.4 1.4 1.9 2 0 0 2 2 2 0 C1 domain zf-RanBP PF00641.18 CCM01322.1 - 0.5 9.7 2.3 0.71 9.2 0.3 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zf-UDP PF14569.6 CCM01322.1 - 0.91 9.7 3.1 1.9 8.6 3.1 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger Actin PF00022.19 CCM01323.1 - 1.3e-100 336.9 0.0 6.5e-100 334.6 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CCM01323.1 - 0.0049 15.7 0.0 0.012 14.5 0.0 1.6 1 1 0 1 1 1 1 MreB/Mbl protein RNA_pol_Rbc25 PF08292.12 CCM01324.1 - 6.4e-31 107.3 0.0 8.8e-31 106.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Mito_carr PF00153.27 CCM01325.1 - 2.5e-65 216.4 2.8 1.8e-23 82.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SKG6 PF08693.10 CCM01326.1 - 0.0013 18.1 1.5 0.0033 16.8 1.5 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Apt1 PF10351.9 CCM01326.1 - 0.0091 14.9 11.5 0.013 14.4 11.5 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain Utp14 PF04615.13 CCM01326.1 - 0.054 12.1 0.8 0.069 11.7 0.8 1.1 1 0 0 1 1 1 0 Utp14 protein Presenilin PF01080.17 CCM01326.1 - 0.19 10.5 2.6 0.26 10.0 2.6 1.2 1 0 0 1 1 1 0 Presenilin DUF572 PF04502.13 CCM01326.1 - 2.8 7.5 8.6 4.1 6.9 8.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) FUSC_2 PF13515.6 CCM01327.1 - 0.093 12.9 2.1 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Fusaric acid resistance protein-like Phos_pyr_kin PF08543.12 CCM01328.1 - 1.4e-08 34.4 0.0 2.3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CCM01328.1 - 0.0002 20.8 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase UbiA PF01040.18 CCM01329.1 - 8e-35 120.3 7.4 1.2e-22 80.5 3.0 2.2 2 0 0 2 2 2 2 UbiA prenyltransferase family START PF01852.19 CCM01330.1 - 3.5e-26 91.9 0.1 8.7e-10 38.4 0.0 3.9 3 1 0 3 3 3 3 START domain LisH PF08513.11 CCM01331.1 - 6.4e-06 25.9 0.1 1e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 LisH F-box-like PF12937.7 CCM01332.1 - 0.011 15.6 0.4 0.045 13.6 0.0 2.3 2 0 0 2 2 2 0 F-box-like AZUL PF16558.5 CCM01332.1 - 0.022 15.0 0.0 0.042 14.1 0.0 1.4 1 0 0 1 1 1 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A LRR_4 PF12799.7 CCM01332.1 - 0.037 14.5 1.2 9.3 6.8 0.3 3.7 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCM01332.1 - 0.083 12.7 2.0 2 8.3 0.4 3.2 2 1 1 3 3 3 0 Leucine rich repeat Peptidase_M20 PF01546.28 CCM01333.1 - 8.4e-10 38.7 0.0 1.7e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM01333.1 - 2.1e-08 34.0 0.0 4.6e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain HATPase_c PF02518.26 CCM01334.1 - 1.1e-22 80.6 0.0 2.9e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCM01334.1 - 7.3e-17 61.5 0.0 6.3e-15 55.3 0.0 2.6 1 1 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CCM01334.1 - 0.0018 18.3 0.0 0.0062 16.6 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CCM01334.1 - 0.094 12.5 0.0 0.32 10.8 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BAH PF01426.18 CCM01335.1 - 3.2e-12 46.4 0.0 6.1e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 BAH domain PHD PF00628.29 CCM01335.1 - 1.4e-10 40.9 42.0 2.5e-08 33.7 8.9 4.9 4 0 0 4 4 4 2 PHD-finger PHD_2 PF13831.6 CCM01335.1 - 0.0068 15.9 4.6 0.0068 15.9 4.6 5.5 6 0 0 6 6 6 2 PHD-finger ELM2 PF01448.24 CCM01335.1 - 0.047 14.4 0.0 0.13 13.0 0.0 1.8 1 0 0 1 1 1 0 ELM2 domain GATA PF00320.27 CCM01335.1 - 0.077 12.6 10.4 0.18 11.4 7.4 3.0 2 0 0 2 2 2 0 GATA zinc finger AT_hook PF02178.19 CCM01335.1 - 0.14 12.1 2.9 0.36 10.9 2.9 1.7 1 0 0 1 1 1 0 AT hook motif C1_2 PF03107.16 CCM01335.1 - 0.24 11.8 0.1 0.24 11.8 0.1 5.0 6 0 0 6 6 6 0 C1 domain UCH PF00443.29 CCM01336.1 - 9.8e-66 221.9 0.0 1.4e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM01336.1 - 8.7e-19 68.3 0.0 3.1e-15 56.6 0.0 2.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 CCM01336.1 - 0.00066 20.2 0.0 0.0014 19.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.20 CCM01336.1 - 0.024 14.4 0.4 0.051 13.3 0.4 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger FAD_binding_3 PF01494.19 CCM01337.1 - 6.5e-84 282.2 0.0 1.1e-83 281.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CCM01337.1 - 1.3e-34 119.6 0.0 2.3e-34 118.8 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_2 PF00890.24 CCM01337.1 - 1.6e-06 27.5 0.9 6.6e-06 25.5 1.1 1.9 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 CCM01337.1 - 4.8e-06 25.5 0.4 7.3e-06 24.9 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 CCM01337.1 - 1.7e-05 25.0 0.1 5.3e-05 23.4 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM01337.1 - 0.00013 21.3 0.1 0.00028 20.2 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM01337.1 - 0.00017 20.9 0.1 0.00031 20.1 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CCM01337.1 - 0.00021 20.7 1.0 0.00035 19.9 0.5 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM01337.1 - 0.00088 19.8 0.1 0.0056 17.2 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CCM01337.1 - 0.0014 18.3 0.1 0.0032 17.1 0.1 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DAO PF01266.24 CCM01337.1 - 0.0021 17.7 0.5 0.0084 15.7 0.3 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM01337.1 - 0.003 16.7 0.7 0.0065 15.6 0.8 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein GIDA PF01134.22 CCM01337.1 - 0.0048 16.0 0.4 0.0085 15.2 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCM01337.1 - 0.011 15.1 1.0 0.017 14.5 1.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CCM01337.1 - 0.011 15.0 0.1 0.022 14.1 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CCM01337.1 - 0.011 15.3 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 CCM01337.1 - 0.034 14.4 0.0 0.067 13.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 CCM01337.1 - 0.06 13.2 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 CCM01337.1 - 0.12 11.2 0.3 0.24 10.2 0.0 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Peptidase_M20 PF01546.28 CCM01338.1 - 5.1e-35 121.0 0.0 6.5e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM01338.1 - 0.00051 19.9 0.0 0.00098 19.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCM01338.1 - 0.045 13.4 0.0 0.23 11.1 0.0 2.1 2 1 0 2 2 2 0 Peptidase family M28 Peptidase_M20 PF01546.28 CCM01339.1 - 5.8e-28 98.0 0.0 7.5e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM01339.1 - 1.3e-12 47.6 0.0 2.8e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCM01339.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Pyridoxal_deC PF00282.19 CCM01340.1 - 2.6e-20 72.5 0.0 5.9e-10 38.4 0.0 3.2 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain YqzE PF14038.6 CCM01341.1 - 1.4 9.0 6.0 12 6.0 1.6 2.5 2 0 0 2 2 2 0 YqzE-like protein ANAPC4_WD40 PF12894.7 CCM01342.1 - 0.0046 17.2 0.0 0.34 11.2 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCM01342.1 - 0.033 15.1 0.1 0.37 11.7 0.1 2.6 3 0 0 3 3 3 0 WD domain, G-beta repeat SET PF00856.28 CCM01343.1 - 2.4e-09 37.8 0.1 1.4e-08 35.4 0.1 2.1 1 1 0 1 1 1 1 SET domain Exo70 PF03081.15 CCM01344.1 - 4.3e-50 170.8 0.2 7.8e-50 170.0 0.2 1.4 1 0 0 1 1 1 1 Exo70 exocyst complex subunit CBFD_NFYB_HMF PF00808.23 CCM01344.1 - 1.3e-28 99.1 0.1 8.4e-26 90.0 0.2 3.1 3 0 0 3 3 3 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM01344.1 - 0.0003 21.1 0.0 0.0007 20.0 0.0 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 F-box-like PF12937.7 CCM01344.1 - 0.0026 17.6 0.1 0.0076 16.1 0.1 1.7 1 0 0 1 1 1 1 F-box-like CENP-T_C PF15511.6 CCM01344.1 - 0.032 14.3 0.0 0.25 11.4 0.0 2.3 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 CCM01344.1 - 0.049 13.7 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit Methyltransf_25 PF13649.6 CCM01345.1 - 4.2e-07 30.6 0.0 7.5e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM01345.1 - 1.6e-05 25.5 0.0 2.6e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM01345.1 - 0.0016 18.3 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM01345.1 - 0.019 15.7 0.0 0.036 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CCM01345.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family UNC-93 PF05978.16 CCM01346.1 - 1.2e-13 51.0 7.7 1.2e-13 51.0 7.7 2.5 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 CCM01346.1 - 2.7e-13 49.6 39.6 2.7e-13 49.6 39.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily RNA_lig_T4_1 PF09511.10 CCM01347.1 - 9.3e-85 283.9 0.0 1.5e-84 283.3 0.0 1.3 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 CCM01347.1 - 5.9e-28 98.1 0.2 1.1e-27 97.2 0.2 1.4 1 0 0 1 1 1 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 CCM01347.1 - 1.6e-24 86.7 0.0 3.6e-24 85.6 0.0 1.6 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain KTI12 PF08433.10 CCM01347.1 - 0.026 14.0 0.1 0.061 12.8 0.1 1.6 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.6 CCM01347.1 - 0.028 14.9 0.0 0.14 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain 2_5_RNA_ligase2 PF13563.6 CCM01347.1 - 0.035 14.0 0.0 0.51 10.2 0.0 2.7 3 0 0 3 3 3 0 2'-5' RNA ligase superfamily Mis12 PF05859.12 CCM01349.1 - 4.1e-38 130.5 0.1 9.4e-38 129.3 0.1 1.6 1 0 0 1 1 1 1 Mis12 protein Ribosomal_L14e PF01929.17 CCM01349.1 - 1.2e-29 102.6 0.5 3.1e-29 101.3 0.5 1.8 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 CCM01349.1 - 7.3e-06 25.8 0.3 1.3e-05 25.0 0.3 1.4 1 0 0 1 1 1 1 KOW motif MetOD2 PF18548.1 CCM01349.1 - 0.054 13.6 0.1 0.16 12.1 0.1 1.8 1 0 0 1 1 1 0 Metanogen output domain 2 Lzipper-MIP1 PF14389.6 CCM01349.1 - 0.086 13.1 4.0 0.083 13.2 1.6 2.2 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 ATP_bind_1 PF03029.17 CCM01350.1 - 2.9e-76 256.4 0.0 3.6e-76 256.2 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Cellulase PF00150.18 CCM01351.1 - 0.065 12.7 0.1 0.088 12.2 0.1 1.2 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) LCIB_C_CA PF18599.1 CCM01351.1 - 0.16 11.2 0.2 0.54 9.5 0.0 1.7 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases CNH PF00780.22 CCM01353.1 - 9.7e-75 251.7 0.0 1.5e-74 251.1 0.0 1.3 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 CCM01353.1 - 9.7e-39 132.6 0.6 1.9e-38 131.6 0.6 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 CCM01353.1 - 1.5e-37 129.6 0.0 2.4e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 CCM01353.1 - 8.4e-14 51.4 0.1 2.1e-13 50.1 0.1 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_13 PF16652.5 CCM01353.1 - 7.3e-05 22.6 0.8 0.0011 18.9 0.8 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CCM01353.1 - 0.039 14.4 0.0 0.13 12.7 0.0 2.0 1 0 0 1 1 1 0 PH domain Sec1 PF00995.23 CCM01354.1 - 7.1e-129 431.7 0.0 8.5e-129 431.4 0.0 1.1 1 0 0 1 1 1 1 Sec1 family Carn_acyltransf PF00755.20 CCM01355.1 - 1.4e-171 572.1 0.0 1.6e-171 571.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase F-box-like PF12937.7 CCM01356.1 - 0.0045 16.9 1.9 0.012 15.4 1.9 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01356.1 - 0.26 11.2 2.3 1.1 9.3 2.3 2.1 1 1 0 1 1 1 0 F-box domain Ribosomal_L5_C PF00673.21 CCM01357.1 - 5.8e-20 71.3 0.0 1.1e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CCM01357.1 - 3.1e-19 69.0 0.0 1.1e-18 67.3 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L5 EI24 PF07264.11 CCM01358.1 - 1.1e-13 51.8 10.0 1.1e-13 51.8 10.0 1.6 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) UNC-93 PF05978.16 CCM01358.1 - 0.026 14.3 0.6 0.053 13.2 0.6 1.4 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 UDPGT PF00201.18 CCM01359.1 - 2.5e-13 49.7 0.0 3.7e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ADIP PF11559.8 CCM01360.1 - 9.1e-22 77.8 8.4 9.1e-22 77.8 8.4 3.4 4 0 0 4 4 4 2 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 CCM01360.1 - 0.0027 17.1 20.8 0.013 14.8 8.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) ATG16 PF08614.11 CCM01360.1 - 0.0095 16.2 33.0 0.043 14.1 9.3 3.4 3 0 0 3 3 3 2 Autophagy protein 16 (ATG16) DUF5346 PF17281.2 CCM01360.1 - 0.013 15.5 0.6 0.033 14.2 0.6 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5346) Tup_N PF08581.10 CCM01360.1 - 0.097 13.0 4.2 8.8 6.7 1.6 2.8 2 0 0 2 2 2 0 Tup N-terminal DUF812 PF05667.11 CCM01360.1 - 0.12 11.2 14.2 0.66 8.8 3.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF812) SPATA24 PF15175.6 CCM01360.1 - 0.26 11.2 9.2 0.49 10.3 1.6 2.5 2 0 0 2 2 2 0 Spermatogenesis-associated protein 24 RasGAP_C PF03836.15 CCM01360.1 - 0.32 11.1 9.2 12 6.0 0.6 3.4 3 0 0 3 3 3 0 RasGAP C-terminus SseC PF04888.12 CCM01360.1 - 0.63 9.6 8.9 3.1 7.3 1.2 2.3 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Golgin_A5 PF09787.9 CCM01360.1 - 1.1 8.7 21.8 0.17 11.3 4.3 2.7 3 0 0 3 3 3 0 Golgin subfamily A member 5 LMBR1 PF04791.16 CCM01360.1 - 2 7.3 6.1 1.9 7.3 0.2 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein Filament PF00038.21 CCM01360.1 - 2.9 7.4 19.9 1.4 8.5 2.3 2.5 2 1 0 2 2 2 0 Intermediate filament protein Macoilin PF09726.9 CCM01360.1 - 3.1 6.2 14.1 1.8 7.1 3.8 2.2 2 0 0 2 2 2 0 Macoilin family vATP-synt_E PF01991.18 CCM01360.1 - 6 6.2 14.8 3.3 7.1 4.8 2.6 2 1 0 2 2 2 0 ATP synthase (E/31 kDa) subunit APG6_N PF17675.1 CCM01360.1 - 6.8 7.2 38.3 0.23 12.0 6.5 3.6 3 1 1 4 4 3 0 Apg6 coiled-coil region FAD_binding_3 PF01494.19 CCM01361.1 - 7e-81 272.2 0.2 8.9e-64 215.9 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain Phe_hydrox_dim PF07976.12 CCM01361.1 - 1.9e-35 122.3 0.0 3.5e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain HI0933_like PF03486.14 CCM01361.1 - 4.4e-07 29.0 0.6 6.8e-07 28.3 0.6 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CCM01361.1 - 3e-06 26.6 2.1 4.9e-06 25.9 2.1 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCM01361.1 - 1e-05 25.7 0.2 2.4e-05 24.5 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM01361.1 - 2e-05 24.0 1.0 0.00014 21.3 0.6 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM01361.1 - 3.6e-05 23.2 0.5 6.1e-05 22.4 0.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM01361.1 - 7.1e-05 22.2 0.1 0.00013 21.3 0.1 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCM01361.1 - 0.00047 19.8 1.1 0.00093 18.9 0.8 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCM01361.1 - 0.0011 19.5 0.3 0.0074 16.8 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCM01361.1 - 0.0022 17.2 1.3 0.0033 16.6 1.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCM01361.1 - 0.0041 16.5 0.5 0.007 15.8 0.5 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM01361.1 - 0.0043 16.2 2.3 0.0089 15.1 1.4 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein SE PF08491.10 CCM01361.1 - 0.0047 16.0 0.0 0.019 14.0 0.0 1.9 1 1 0 1 1 1 1 Squalene epoxidase AlaDh_PNT_C PF01262.21 CCM01361.1 - 0.01 15.2 0.1 0.017 14.5 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 CCM01361.1 - 0.015 15.0 0.1 0.027 14.1 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 CCM01361.1 - 0.021 13.7 0.1 0.032 13.1 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase 3HCDH_N PF02737.18 CCM01361.1 - 0.081 12.8 0.1 0.25 11.2 0.1 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Bac_globin PF01152.21 CCM01361.1 - 0.14 12.3 0.0 0.71 10.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial-like globin UDPG_MGDP_dh_N PF03721.14 CCM01361.1 - 0.19 11.3 0.3 0.32 10.6 0.3 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Mito_fiss_reg PF05308.11 CCM01363.1 - 1.7 8.7 7.0 2.8 7.9 7.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator CorA PF01544.18 CCM01365.1 - 1.9e-29 102.9 6.6 4.4e-26 91.9 4.7 2.9 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein MGAT2 PF05060.14 CCM01365.1 - 0.013 14.5 1.1 0.062 12.4 0.1 2.0 2 0 0 2 2 2 0 N-acetylglucosaminyltransferase II (MGAT2) DNA_pol_delta_4 PF04081.13 CCM01366.1 - 6.7e-29 100.9 3.3 9.8e-29 100.3 0.0 2.4 3 0 0 3 3 3 1 DNA polymerase delta, subunit 4 AKAP_110 PF05716.13 CCM01366.1 - 2.2 6.4 6.4 3 6.0 6.4 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) WLM PF08325.10 CCM01367.1 - 1.4e-40 139.4 1.1 1e-39 136.6 0.0 2.0 2 0 0 2 2 2 1 WLM domain ubiquitin PF00240.23 CCM01367.1 - 1.8e-10 40.4 0.0 4.2e-10 39.2 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 CCM01367.1 - 5.3e-05 23.6 0.3 0.0002 21.7 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CCM01367.1 - 0.001 18.9 0.0 0.0029 17.5 0.0 1.7 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD PF11976.8 CCM01367.1 - 0.01 15.6 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Zincin_1 PF06262.11 CCM01367.1 - 0.11 12.6 0.2 0.63 10.2 0.1 2.3 1 1 1 2 2 2 0 Zincin-like metallopeptidase BTB PF00651.31 CCM01368.1 - 7.1e-10 39.1 0.0 1.3e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Peptidase_M20 PF01546.28 CCM01369.1 - 3.7e-12 46.4 0.5 6.6e-12 45.6 0.5 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM01369.1 - 4.2e-06 26.6 0.1 1.6e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain p450 PF00067.22 CCM01370.1 - 8.3e-75 252.3 0.0 1e-74 252.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 2OG-FeII_Oxy PF03171.20 CCM01371.1 - 1.1e-14 54.7 0.0 2e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCM01371.1 - 1.3e-14 54.9 0.0 3.2e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal TauD PF02668.16 CCM01372.1 - 1.1e-49 169.6 0.2 2e-49 168.8 0.0 1.4 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 CCM01372.1 - 4.1e-11 43.4 0.1 8e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF971) Gln-synt_C PF00120.24 CCM01373.1 - 1.3e-68 231.5 0.0 1.9e-68 231.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Glyco_hydro_5_C PF18564.1 CCM01373.1 - 3.7e-24 85.1 0.0 8.3e-24 84.0 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 CCM01373.1 - 2.2e-13 50.3 0.0 1.9e-08 34.1 0.0 2.9 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) NAD_binding_4 PF07993.12 CCM01374.1 - 1.7e-35 122.5 0.0 3.5e-35 121.4 0.0 1.5 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 CCM01374.1 - 8.7e-33 113.5 0.0 4e-32 111.3 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.21 CCM01374.1 - 2.6e-07 30.3 0.0 4.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM01374.1 - 0.015 15.7 0.0 0.056 13.8 0.0 2.0 1 1 0 1 1 1 0 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 CCM01374.1 - 0.056 12.4 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ribosomal_L14 PF00238.19 CCM01375.1 - 2e-45 153.8 1.4 2.4e-45 153.6 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Hexokinase_1 PF00349.21 CCM01376.1 - 4.7e-68 229.0 0.0 6.9e-68 228.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 CCM01376.1 - 1.7e-39 135.7 0.0 1.2e-38 132.9 0.0 2.0 1 1 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 CCM01377.1 - 2.5e-30 105.7 0.2 2.9e-30 105.5 0.2 1.0 1 0 0 1 1 1 1 Hexokinase YjgF_endoribonc PF14588.6 CCM01377.1 - 0.035 14.3 0.0 0.041 14.0 0.0 1.1 1 0 0 1 1 1 0 YjgF/chorismate_mutase-like, putative endoribonuclease NLE PF08154.12 CCM01378.1 - 1.5e-14 54.3 0.0 2.8e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 CCM01378.1 - 2.7e-10 40.7 18.7 0.06 14.2 0.1 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat MaoC_dehydratas PF01575.19 CCM01379.1 - 3e-27 94.6 0.0 1.6e-26 92.3 0.0 1.9 2 0 0 2 2 2 1 MaoC like domain Peptidase_M48 PF01435.18 CCM01381.1 - 1.7e-16 60.6 0.0 2.8e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 XhlA PF10779.9 CCM01381.1 - 3.1 8.1 5.3 0.6 10.4 1.0 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Svf1_C PF17187.4 CCM01382.1 - 3e-37 128.0 0.0 3.4e-37 127.8 0.0 1.0 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain F-box-like PF12937.7 CCM01383.1 - 0.064 13.2 1.3 0.21 11.5 1.3 1.9 1 0 0 1 1 1 0 F-box-like GTF2I PF02946.14 CCM01384.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 GTF2I-like repeat Caudal_act PF04731.12 CCM01384.1 - 0.2 12.0 1.6 0.37 11.1 0.5 1.9 1 1 1 2 2 2 0 Caudal like protein activation region DUF155 PF02582.14 CCM01385.1 - 1.9e-46 158.4 0.0 2.9e-46 157.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 TPR_19 PF14559.6 CCM01385.1 - 5.2e-12 46.1 5.9 0.00017 22.0 0.1 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM01385.1 - 7.5e-09 36.1 3.7 3.7e-05 24.3 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCM01385.1 - 6.7e-06 26.5 8.5 0.42 11.6 0.0 5.9 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCM01385.1 - 2e-05 24.7 0.1 0.89 10.1 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCM01385.1 - 2.3e-05 24.6 1.7 0.74 10.2 0.0 4.5 4 1 0 4 4 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCM01385.1 - 5.3e-05 23.2 0.4 0.00072 19.6 0.1 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 CCM01385.1 - 5.5e-05 23.0 9.7 0.33 11.2 0.0 6.3 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM01385.1 - 0.00037 20.2 1.5 18 5.4 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM01385.1 - 0.0027 17.9 1.6 22 5.4 0.1 4.0 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CCM01385.1 - 0.0054 16.7 0.8 1.1 9.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01385.1 - 0.0079 16.3 0.1 5.6 7.4 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCM01385.1 - 0.029 13.6 0.3 0.42 9.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCM01385.1 - 0.09 12.7 2.7 4.9 7.2 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCM01385.1 - 6.3 7.7 9.0 2e+02 2.9 0.2 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat SART-1 PF03343.13 CCM01386.1 - 6.2e-167 556.9 52.7 6.2e-167 556.9 52.7 1.7 2 0 0 2 2 2 1 SART-1 family Arg_tRNA_synt_N PF03485.16 CCM01386.1 - 2.8 8.6 5.5 32 5.2 0.2 3.0 3 0 0 3 3 3 0 Arginyl tRNA synthetase N terminal domain RNase_HII PF01351.18 CCM01387.1 - 5.7e-45 153.6 0.0 3.2e-43 147.9 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease HII MA3 PF02847.17 CCM01388.1 - 2.4e-21 75.8 0.0 9.8e-21 73.9 0.0 2.1 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 CCM01388.1 - 3.4e-19 69.4 0.5 6.3e-19 68.5 0.1 1.6 2 0 0 2 2 2 1 MIF4G domain MgpC PF05220.12 CCM01388.1 - 0.14 11.5 0.1 0.27 10.5 0.1 1.3 1 0 0 1 1 1 0 MgpC protein precursor GvpL_GvpF PF06386.11 CCM01388.1 - 0.27 11.1 1.6 3.1 7.6 0.0 2.5 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Methyltransf_31 PF13847.6 CCM01389.1 - 7.7e-12 45.2 0.0 1.4e-07 31.4 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 CCM01389.1 - 2.5e-06 28.1 0.3 1.2e-05 26.0 0.3 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM01389.1 - 7.2e-05 23.5 0.1 0.00017 22.3 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCM01389.1 - 0.00024 21.1 0.0 0.00032 20.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM01389.1 - 0.00044 20.9 0.4 0.0054 17.3 0.4 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM01389.1 - 0.0011 18.8 0.0 0.0019 18.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCM01389.1 - 0.0033 17.0 0.0 0.0052 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Pam16 PF03656.13 CCM01390.1 - 9.8e-05 22.4 0.0 0.00011 22.2 0.0 1.1 1 0 0 1 1 1 1 Pam16 Dyp_perox PF04261.12 CCM01390.1 - 0.0012 17.9 0.0 0.0013 17.8 0.0 1.0 1 0 0 1 1 1 1 Dyp-type peroxidase family DnaJ PF00226.31 CCM01390.1 - 0.0012 18.9 0.1 0.002 18.2 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain AAA_12 PF13087.6 CCM01391.1 - 1.3e-32 113.1 0.3 9.5e-32 110.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCM01391.1 - 1.3e-21 77.6 0.0 8.4e-11 42.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CCM01391.1 - 1.6e-17 63.8 0.0 4.1e-17 62.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM01391.1 - 2.7e-13 50.5 0.0 6.7e-13 49.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCM01391.1 - 1.3e-05 25.7 0.0 3.5e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain PhoH PF02562.16 CCM01391.1 - 0.00088 18.8 0.0 0.24 10.9 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 CCM01391.1 - 0.0012 19.1 0.0 0.008 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CCM01391.1 - 0.002 18.1 0.0 0.0041 17.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CCM01391.1 - 0.0042 16.4 0.1 0.013 14.7 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 CCM01391.1 - 0.0053 16.0 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 CCM01391.1 - 0.0059 17.0 0.1 0.014 15.8 0.1 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 CCM01391.1 - 0.0062 16.1 0.8 0.053 13.0 0.0 2.5 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain T2SSE PF00437.20 CCM01391.1 - 0.0097 15.0 0.3 0.019 14.0 0.1 1.5 2 0 0 2 2 2 1 Type II/IV secretion system protein Helicase_RecD PF05127.14 CCM01391.1 - 0.011 15.6 0.1 0.11 12.4 0.1 2.3 1 1 0 1 1 1 0 Helicase ATPase_2 PF01637.18 CCM01391.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 CCM01391.1 - 0.045 13.5 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.29 CCM01391.1 - 0.079 12.7 0.1 0.33 10.7 0.1 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 CCM01391.1 - 0.08 12.7 1.0 1 9.1 0.1 2.8 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 CCM01391.1 - 0.083 12.4 0.1 0.46 10.0 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF1827 PF08860.10 CCM01391.1 - 0.088 13.1 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) Rad17 PF03215.15 CCM01391.1 - 0.095 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 CCM01391.1 - 0.17 12.4 0.3 0.54 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Carn_acyltransf PF00755.20 CCM01392.1 - 8.3e-121 404.5 0.0 9.3e-121 404.3 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RMI1_N PF08585.12 CCM01393.1 - 1.6e-40 139.2 0.0 4.8e-40 137.6 0.0 1.8 2 0 0 2 2 2 1 RecQ mediated genome instability protein Herpes_capsid PF06112.11 CCM01393.1 - 5.7 7.0 10.1 13 5.8 10.1 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein DnaJ PF00226.31 CCM01394.1 - 3.8e-17 62.1 5.4 1.6e-16 60.2 1.7 2.6 2 0 0 2 2 2 1 DnaJ domain Jak1_Phl PF17887.1 CCM01394.1 - 1.5 8.8 6.6 3.4 7.6 6.6 1.5 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain CtaG_Cox11 PF04442.14 CCM01395.1 - 1.3e-59 200.6 0.0 1.6e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 LsmAD PF06741.13 CCM01397.1 - 1.9e-25 89.2 2.0 4.1e-25 88.1 2.0 1.6 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 CCM01397.1 - 0.035 14.3 0.0 0.082 13.1 0.0 1.6 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM14 PF12701.7 CCM01397.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Scd6-like Sm domain Mad3_BUB1_I PF08311.12 CCM01398.1 - 2e-35 121.5 1.7 4e-35 120.5 1.7 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 CCM01398.1 - 2.7e-13 49.9 0.0 8.4e-13 48.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01398.1 - 3.9e-09 36.2 0.0 5.7e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 CCM01398.1 - 0.0019 18.3 0.0 0.0075 16.4 0.0 2.0 2 0 0 2 2 2 1 Putative Mad3/BUB1 like region 1 protein Mad3_BUB1_II PF08171.11 CCM01398.1 - 0.0049 17.0 0.0 0.02 15.0 0.0 2.0 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 APH PF01636.23 CCM01398.1 - 0.039 13.9 0.3 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family MtN3_slv PF03083.16 CCM01398.1 - 1.3 9.1 2.7 0.77 9.8 0.5 1.7 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Lipoprotein_3 PF00938.17 CCM01399.1 - 0.023 14.9 1.0 1.8 8.8 0.7 2.2 1 1 1 2 2 2 0 Lipoprotein RhoGEF PF00621.20 CCM01400.1 - 7.6e-28 98.0 0.5 1.1e-27 97.4 0.5 1.3 1 0 0 1 1 1 1 RhoGEF domain CNH PF00780.22 CCM01400.1 - 4.2e-26 92.2 0.0 6.2e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 CCM01400.1 - 2.5e-11 43.8 0.0 8.9e-11 42.0 0.0 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 CCM01400.1 - 5.5e-05 23.0 0.0 0.026 14.4 0.0 2.4 2 0 0 2 2 2 2 PH domain PH PF00169.29 CCM01400.1 - 0.0035 17.8 0.0 0.017 15.6 0.0 2.2 1 1 0 1 1 1 1 PH domain SOG2 PF10428.9 CCM01401.1 - 1 8.5 15.4 1.1 8.4 15.4 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein WD40 PF00400.32 CCM01402.1 - 1.1e-29 102.0 8.6 9.2e-07 29.5 0.0 8.4 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM01402.1 - 2.3e-10 40.6 0.1 0.00012 22.3 0.0 5.0 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCM01402.1 - 5.6e-05 22.8 2.5 0.0085 15.7 0.9 3.1 1 1 1 2 2 2 2 PQQ-like domain Ge1_WD40 PF16529.5 CCM01402.1 - 5.9e-05 22.2 0.0 0.034 13.1 0.0 3.1 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCM01402.1 - 0.054 12.8 0.0 2.8 7.2 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain Nup160 PF11715.8 CCM01402.1 - 0.089 11.4 0.0 5.7 5.5 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Exo_endo_phos PF03372.23 CCM01403.1 - 3e-07 30.2 0.0 5.3e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Alpha-amylase PF00128.24 CCM01404.1 - 1.4e-25 90.6 0.0 7e-24 85.0 0.0 2.1 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 CCM01404.1 - 0.0013 17.0 0.0 0.7 8.0 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolase family 70 DUF1939 PF09154.10 CCM01404.1 - 0.085 13.0 0.2 0.23 11.7 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) PRIMA1 PF16101.5 CCM01405.1 - 0.073 13.1 7.4 0.086 12.9 4.2 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 GyrB_insert PF18053.1 CCM01405.1 - 0.14 12.1 0.0 0.14 12.1 0.0 2.3 2 0 0 2 2 2 0 DNA gyrase B subunit insert domain Mito_fiss_reg PF05308.11 CCM01405.1 - 0.16 12.0 7.1 0.25 11.4 6.7 1.6 1 1 0 1 1 1 0 Mitochondrial fission regulator YabA PF06156.13 CCM01405.1 - 0.56 10.9 2.7 2 9.1 2.7 1.9 1 0 0 1 1 1 0 Initiation control protein YabA DUF4407 PF14362.6 CCM01405.1 - 0.93 8.8 9.1 3.5 6.9 9.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 CCM01405.1 - 2.4 8.7 11.9 7 7.2 11.9 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 CCM01405.1 - 3.1 8.0 12.3 0.99 9.6 6.1 3.0 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding OmpH PF03938.14 CCM01405.1 - 7.8 6.8 11.8 19 5.6 11.8 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Rota_NSP4 PF01452.16 CCM01408.1 - 0.017 14.8 1.2 0.034 13.8 1.2 1.4 1 0 0 1 1 1 0 Rotavirus non structural protein Clr5 PF14420.6 CCM01408.1 - 0.081 13.2 0.9 2.5 8.4 0.3 2.7 2 0 0 2 2 2 0 Clr5 domain Filament PF00038.21 CCM01408.1 - 0.15 11.6 62.5 0.24 10.9 45.8 3.3 1 1 2 3 3 3 0 Intermediate filament protein Phage_GP20 PF06810.11 CCM01408.1 - 5.5 6.8 49.4 7.4 6.4 11.8 5.0 2 1 3 5 5 5 0 Phage minor structural protein GP20 FOXP-CC PF16159.5 CCM01408.1 - 8.8 7.0 10.7 11 6.7 0.7 4.0 3 0 0 3 3 3 0 FOXP coiled-coil domain Abhydrolase_1 PF00561.20 CCM01410.1 - 2.1e-30 106.2 0.1 4.1e-30 105.3 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Sad1_UNC PF07738.13 CCM01410.1 - 2.5e-23 82.5 0.0 1.1e-10 41.6 0.0 2.4 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal Hydrolase_4 PF12146.8 CCM01410.1 - 2.9e-10 39.8 0.0 6.5e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CCM01410.1 - 0.022 13.5 0.0 0.036 12.8 0.0 1.3 1 0 0 1 1 1 0 Ndr family Seryl_tRNA_N PF02403.22 CCM01410.1 - 2.5 8.4 5.4 7.5 6.8 5.4 1.8 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain NOA36 PF06524.12 CCM01410.1 - 8.7 5.6 9.0 13 5.0 9.0 1.2 1 0 0 1 1 1 0 NOA36 protein C2 PF00168.30 CCM01411.1 - 5.6e-13 49.1 0.0 1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain CCDC50_N PF15295.6 CCM01411.1 - 0.082 13.1 6.2 0.14 12.4 6.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Sugar_tr PF00083.24 CCM01414.1 - 5.6e-92 309.0 20.9 6.3e-92 308.8 20.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM01414.1 - 6.4e-21 74.7 39.9 2.4e-14 53.1 23.7 2.8 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 CCM01414.1 - 0.064 11.8 20.9 0.13 10.8 0.5 2.8 2 1 1 3 3 3 0 MFS/sugar transport protein ABC_membrane PF00664.23 CCM01415.1 - 4.4e-56 190.5 23.5 3.2e-31 109.0 10.1 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCM01415.1 - 3.3e-50 170.2 0.0 4.5e-28 98.5 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCM01415.1 - 4.8e-08 32.7 0.0 0.002 17.6 0.0 3.8 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCM01415.1 - 1.5e-06 28.7 0.2 0.089 13.2 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CCM01415.1 - 1.1e-05 25.5 2.9 0.044 13.9 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 CCM01415.1 - 0.00012 21.7 1.5 0.36 10.6 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCM01415.1 - 0.00034 20.6 3.0 0.17 11.8 0.1 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_25 PF13481.6 CCM01415.1 - 0.0023 17.6 0.4 2.4 7.7 0.1 3.4 3 0 0 3 3 3 1 AAA domain Dynamin_N PF00350.23 CCM01415.1 - 0.004 17.2 4.7 0.14 12.2 1.4 2.7 2 0 0 2 2 2 1 Dynamin family AAA_21 PF13304.6 CCM01415.1 - 0.0049 16.7 9.0 2.3 8.0 0.2 4.3 4 1 1 5 5 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 CCM01415.1 - 0.014 14.7 0.8 0.52 9.6 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 CCM01415.1 - 0.018 15.6 0.0 4.2 7.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CCM01415.1 - 0.018 15.1 4.5 0.47 10.5 0.5 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_30 PF13604.6 CCM01415.1 - 0.022 14.5 0.6 9.8 5.8 0.4 3.2 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 CCM01415.1 - 0.025 14.5 1.5 0.47 10.4 0.2 2.5 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 CCM01415.1 - 0.028 13.6 0.9 6.6 5.8 0.4 2.5 2 0 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 CCM01415.1 - 0.036 13.4 0.7 2.2 7.6 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 CCM01415.1 - 0.055 13.2 0.1 0.44 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCM01415.1 - 0.074 13.3 4.6 3.6 7.9 0.4 3.0 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCM01415.1 - 0.077 13.1 4.3 20 5.4 0.6 3.6 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 CCM01415.1 - 0.099 12.9 1.2 11 6.3 0.1 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CCM01415.1 - 0.18 11.5 3.1 15 5.2 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 CCM01415.1 - 0.23 11.9 1.1 24 5.4 0.0 3.2 3 0 0 3 3 2 0 RNA helicase TsaE PF02367.17 CCM01415.1 - 0.23 11.5 1.6 5.1 7.1 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 CCM01415.1 - 0.27 10.7 2.3 9.4 5.7 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region MobB PF03205.14 CCM01415.1 - 0.31 11.0 3.1 10 6.0 0.1 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B TrwB_AAD_bind PF10412.9 CCM01415.1 - 0.48 9.3 3.3 2.1 7.1 0.2 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 CCM01415.1 - 3.8 7.1 8.2 1.6 8.3 0.4 2.7 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CCM01415.1 - 4.1 6.3 8.7 7.3 5.5 0.2 3.2 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Fungal_trans PF04082.18 CCM01416.1 - 9.5e-08 31.4 0.1 1.5e-07 30.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 CCM01417.1 - 2.8e-70 237.4 0.0 3.3e-70 237.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM01420.1 - 1.3e-49 169.2 0.0 1.8e-49 168.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM01421.1 - 0.00039 19.3 0.1 0.00045 19.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF5395 PF17373.2 CCM01421.1 - 0.12 13.0 0.1 0.17 12.6 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5395) Actin PF00022.19 CCM01422.1 - 1.9e-48 165.1 0.0 6.9e-26 90.8 0.0 2.3 2 0 0 2 2 2 2 Actin Ras PF00071.22 CCM01423.1 - 4.2e-64 215.0 0.0 4.8e-64 214.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM01423.1 - 6.8e-34 116.7 0.1 1.1e-33 116.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM01423.1 - 5.8e-14 51.9 0.1 7.4e-14 51.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM01423.1 - 8.5e-06 25.4 0.1 1.9e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCM01423.1 - 3.8e-05 23.7 0.0 0.00027 21.0 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCM01423.1 - 0.00011 21.7 0.0 0.00012 21.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CCM01423.1 - 0.00016 21.7 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CCM01423.1 - 0.016 15.6 0.0 0.026 14.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 CCM01423.1 - 0.024 14.2 0.0 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.6 CCM01423.1 - 0.044 13.5 0.1 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain SRPRB PF09439.10 CCM01423.1 - 0.057 12.8 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NACHT PF05729.12 CCM01423.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 CCM01423.1 - 0.087 12.1 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Septin MCM PF00493.23 CCM01423.1 - 0.13 11.3 0.0 0.33 10.0 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain UvrD_C PF13361.6 CCM01424.1 - 8.3e-09 35.3 0.0 7.5e-07 28.8 0.0 2.8 2 1 0 3 3 3 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 CCM01424.1 - 1.5e-06 28.0 0.8 8e-05 22.3 0.0 3.1 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 CCM01424.1 - 1.5e-05 24.7 0.0 0.013 15.3 0.0 2.8 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 CCM01424.1 - 0.0034 17.7 0.0 0.081 13.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCM01424.1 - 0.004 17.5 0.1 0.073 13.4 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CCM01424.1 - 0.033 13.8 0.0 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain HTH_18 PF12833.7 CCM01424.1 - 0.037 14.3 0.7 4.1 7.7 0.0 2.9 2 0 0 2 2 2 0 Helix-turn-helix domain DEAD PF00270.29 CCM01424.1 - 0.054 13.3 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase TPR_1 PF00515.28 CCM01424.1 - 0.35 10.8 4.4 2 8.4 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 CCM01424.1 - 1.3 8.4 9.4 0.67 9.3 5.7 2.1 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP BAR PF03114.18 CCM01425.1 - 7.2e-24 84.7 1.3 1.4e-16 60.9 1.1 2.1 2 0 0 2 2 2 2 BAR domain SH3_1 PF00018.28 CCM01425.1 - 1.9e-14 53.0 0.1 3.2e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCM01425.1 - 1.2e-11 44.2 0.2 2.2e-11 43.4 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCM01425.1 - 6.4e-10 38.6 0.0 1.1e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain HlyE PF06109.13 CCM01425.1 - 0.067 12.5 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Haemolysin E (HlyE) Tmemb_55A PF09788.9 CCM01425.1 - 4.1 6.4 4.2 12 4.9 4.2 1.7 1 1 0 1 1 1 0 Transmembrane protein 55A SBDS PF01172.18 CCM01426.1 - 2.9e-35 120.2 0.9 4.9e-35 119.5 0.9 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 CCM01426.1 - 6.7e-33 113.1 0.1 1.2e-32 112.3 0.1 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain p450 PF00067.22 CCM01427.1 - 2.5e-54 184.8 0.0 3.2e-54 184.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1541 PF07563.11 CCM01427.1 - 0.02 14.8 2.3 0.055 13.3 2.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1541) DUF1043 PF06295.12 CCM01427.1 - 0.18 11.8 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DOT1 PF08123.13 CCM01428.1 - 3.6e-65 219.3 0.0 5.1e-65 218.9 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 CCM01428.1 - 0.042 14.5 0.0 0.086 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CCM01428.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DEAD PF00270.29 CCM01429.1 - 3.6e-36 124.6 0.0 6.5e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM01429.1 - 2e-31 108.6 0.0 1.4e-28 99.5 0.0 2.6 2 1 1 3 3 3 2 Helicase conserved C-terminal domain CMS1 PF14617.6 CCM01429.1 - 0.019 14.3 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 CCM01429.1 - 0.036 13.3 0.0 0.064 12.4 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase HET PF06985.11 CCM01430.1 - 2.7e-25 89.4 0.1 1.8e-24 86.8 0.1 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) LSM PF01423.22 CCM01431.1 - 1.3e-07 31.2 0.0 1.6e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCM01431.1 - 0.13 12.4 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain Chorismate_synt PF01264.21 CCM01432.1 - 4.5e-139 462.7 0.0 5.2e-139 462.5 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Secretin_N_2 PF07655.13 CCM01433.1 - 0.0062 17.0 0.2 0.019 15.5 0.0 1.9 2 0 0 2 2 2 1 Secretin N-terminal domain UPF0052 PF01933.18 CCM01434.1 - 8.1e-46 156.6 0.0 1.2e-45 156.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 Asp PF00026.23 CCM01437.1 - 1e-18 67.9 11.2 2.2e-10 40.5 0.2 2.2 2 0 0 2 2 2 2 Eukaryotic aspartyl protease Gly-zipper_YMGG PF13441.6 CCM01437.1 - 0.056 13.2 2.3 0.13 12.0 2.3 1.5 1 0 0 1 1 1 0 YMGG-like Gly-zipper Brr6_like_C_C PF10104.9 CCM01438.1 - 1.9e-45 153.9 1.5 2.4e-45 153.6 1.5 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain PBP1_TM PF14812.6 CCM01438.1 - 0.056 13.8 1.1 0.17 12.2 1.1 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CLP_protease PF00574.23 CCM01439.1 - 2e-76 255.9 0.0 2.6e-76 255.5 0.0 1.1 1 0 0 1 1 1 1 Clp protease ECH_1 PF00378.20 CCM01439.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase MOSC PF03473.17 CCM01440.1 - 4.4e-22 78.5 0.0 1.2e-21 77.1 0.0 1.7 2 0 0 2 2 2 1 MOSC domain MOSC_N PF03476.16 CCM01440.1 - 3.5e-07 30.1 0.0 1.4e-05 25.0 0.0 2.3 2 0 0 2 2 2 1 MOSC N-terminal beta barrel domain Histone PF00125.24 CCM01444.1 - 3.3e-45 153.7 8.8 1.5e-43 148.3 8.8 2.0 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CCM01444.1 - 3.1e-05 24.3 0.1 5.3e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CCM01444.1 - 0.00012 22.2 1.5 0.00013 22.0 0.1 1.8 2 1 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 CCM01444.1 - 0.00083 19.6 2.0 0.0018 18.5 0.1 2.1 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 CCM01444.1 - 0.1 12.6 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Bromodomain associated TFIID-31kDa PF02291.15 CCM01444.1 - 0.12 12.4 0.3 0.23 11.5 0.1 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit PAF PF15715.5 CCM01444.1 - 0.61 10.7 6.4 0.99 10.0 6.4 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Peptidase_S10 PF00450.22 CCM01445.1 - 1.9e-51 175.8 0.0 2.2e-51 175.6 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase MOSC PF03473.17 CCM01446.1 - 7.3e-23 81.0 0.0 7.2e-22 77.8 0.0 2.1 2 0 0 2 2 2 1 MOSC domain MOSC_N PF03476.16 CCM01446.1 - 1.2e-14 54.2 0.0 3.3e-14 52.8 0.0 1.7 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain CDP-OH_P_transf PF01066.21 CCM01447.1 - 6.1e-12 46.1 0.0 6.1e-12 46.1 0.0 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase tRNA-synt_His PF13393.6 CCM01448.1 - 3.1e-35 122.0 1.9 3.2e-31 108.8 0.0 3.0 3 1 0 3 3 3 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 CCM01448.1 - 4.1e-09 36.5 0.0 1.1e-08 35.1 0.0 1.8 1 1 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CCM01448.1 - 3.8e-06 27.0 0.0 2e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 CCM01448.1 - 0.0084 15.7 0.5 0.022 14.3 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs TRAF_BIRC3_bd PF16673.5 CCM01448.1 - 0.46 10.3 1.8 1 9.2 1.8 1.6 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain COX5A PF02284.16 CCM01449.1 - 1.2e-39 134.5 0.7 2.1e-39 133.7 0.7 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Ank_5 PF13857.6 CCM01449.1 - 9.2e-13 48.2 0.2 2.2e-07 31.0 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCM01449.1 - 1.7e-12 47.6 0.1 9.4e-07 29.3 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM01449.1 - 2e-11 44.3 0.3 3.9e-05 24.1 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCM01449.1 - 2.4e-11 42.8 0.3 0.00022 21.4 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CCM01449.1 - 2.1e-10 40.6 2.3 0.00035 20.9 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat DUF1115 PF06544.12 CCM01450.1 - 5.9e-07 29.7 0.1 8.8e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) PUF PF00806.19 CCM01451.1 - 2.4e-27 93.1 0.2 2e-07 30.3 0.0 5.9 6 0 0 6 6 6 4 Pumilio-family RNA binding repeat Clp_N PF02861.20 CCM01451.1 - 0.19 11.9 0.8 0.47 10.6 0.8 1.6 1 0 0 1 1 1 0 Clp amino terminal domain, pathogenicity island component Pkinase PF00069.25 CCM01452.1 - 2.3e-74 250.1 0.0 3e-74 249.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01452.1 - 2.9e-39 134.9 0.0 4.1e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 CCM01452.1 - 1.3e-17 64.3 1.0 1.3e-13 51.5 0.4 3.5 1 1 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 CCM01452.1 - 9.7e-14 51.2 0.3 3e-13 49.7 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 CCM01452.1 - 2.2e-06 27.2 0.0 3.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CCM01452.1 - 0.00027 20.6 0.3 0.0008 19.0 0.3 1.7 1 1 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 CCM01452.1 - 0.0052 15.8 0.1 0.008 15.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCM01452.1 - 0.024 14.6 2.3 0.12 12.2 0.2 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 CCM01452.1 - 0.024 14.0 0.7 0.15 11.4 0.7 2.0 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.9 CCM01452.1 - 0.16 10.8 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC CHAT PF12770.7 CCM01453.1 - 2.6e-39 135.4 0.1 4.3e-39 134.7 0.1 1.4 1 0 0 1 1 1 1 CHAT domain TPR_10 PF13374.6 CCM01453.1 - 2.9e-08 33.3 19.7 1.6 8.7 0.0 11.8 15 0 0 15 15 15 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCM01453.1 - 0.002 18.1 1.7 4.4 7.7 0.3 6.6 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01453.1 - 0.0024 18.0 0.2 0.83 10.0 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCM01453.1 - 0.11 13.3 1.1 79 4.5 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.16 CCM01453.1 - 0.46 10.6 2.0 6.7 6.9 0.1 3.9 5 0 0 5 5 5 0 Exonuclease VII small subunit TPR_7 PF13176.6 CCM01453.1 - 0.69 10.1 5.3 4.1 7.7 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCM01453.1 - 1.4 8.9 8.8 11 6.0 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat PLA2_B PF01735.18 CCM01454.1 - 9e-95 317.9 0.5 1.5e-94 317.2 0.5 1.3 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Amidohydro_1 PF01979.20 CCM01455.1 - 7.7e-15 55.1 0.0 1.9e-12 47.2 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 CCM01455.1 - 2.8e-05 23.8 0.8 0.0037 16.8 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family Fe_hyd_lg_C PF02906.14 CCM01457.1 - 4e-29 102.0 0.0 5.8e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Tmemb_9 PF05434.11 CCM01458.1 - 0.035 14.0 0.6 0.052 13.4 0.1 1.5 1 1 1 2 2 2 0 TMEM9 zf-RRN7 PF11781.8 CCM01458.1 - 0.074 12.8 1.7 0.074 12.8 1.7 2.6 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 SNARE PF05739.19 CCM01459.1 - 4.4e-16 58.6 0.2 9.6e-16 57.5 0.2 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 CCM01459.1 - 2.1e-05 24.3 0.4 3.5e-05 23.6 0.4 1.4 1 0 0 1 1 1 1 Syntaxin MS_channel PF00924.18 CCM01460.1 - 7.1e-22 78.0 0.1 1.4e-21 77.0 0.1 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_6 PF13405.6 CCM01460.1 - 0.24 11.4 0.5 0.58 10.2 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain Aa_trans PF01490.18 CCM01461.1 - 1.2e-72 244.9 28.1 1.4e-72 244.6 28.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCM01461.1 - 0.0001 21.5 13.2 0.0001 21.5 13.2 1.9 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family DUF2574 PF10836.8 CCM01461.1 - 0.048 13.5 0.5 77 3.3 0.1 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2574) GHMP_kinases_N PF00288.26 CCM01462.1 - 1.4e-12 47.7 1.1 1.4e-12 47.7 1.1 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCM01462.1 - 5.9e-07 29.8 0.1 1.8e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 GHMP kinases C terminal NFRKB_winged PF14465.6 CCM01462.1 - 0.042 14.0 0.1 0.099 12.8 0.1 1.5 1 0 0 1 1 1 0 NFRKB Winged Helix-like Ferrochelatase PF00762.19 CCM01463.1 - 1.7e-102 342.7 0.0 2e-102 342.5 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 CCM01463.1 - 0.00026 21.3 0.0 0.67 10.3 0.0 3.2 3 0 0 3 3 3 1 CbiX UNC-79 PF14776.6 CCM01463.1 - 0.19 10.5 0.0 0.26 10.0 0.0 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 RNA_pol_A_bac PF01000.26 CCM01465.1 - 1.6e-20 73.5 0.0 4.2e-20 72.2 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CCM01465.1 - 5.9e-19 67.3 0.0 8.4e-19 66.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L_2 PF13656.6 CCM01465.1 - 0.19 11.5 0.0 0.94 9.3 0.0 1.9 2 0 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-RING_2 PF13639.6 CCM01466.1 - 2.9e-09 37.1 1.4 1.2e-07 31.9 0.4 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCM01466.1 - 8e-08 32.0 3.9 3.8e-07 29.8 1.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCM01466.1 - 8.9e-08 32.3 0.5 6.2e-07 29.6 0.2 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CCM01466.1 - 5.5e-06 26.0 0.5 0.0018 18.0 0.1 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 CCM01466.1 - 3.8e-05 23.5 0.3 0.00042 20.1 0.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM01466.1 - 0.00011 22.1 0.5 0.00035 20.5 0.1 1.9 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCM01466.1 - 0.00016 21.4 0.4 0.00036 20.3 0.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CCM01466.1 - 0.00073 19.5 0.4 0.0019 18.2 0.1 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CCM01466.1 - 0.0083 16.1 5.7 0.12 12.4 3.8 3.0 2 1 1 3 3 3 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CCM01466.1 - 0.0099 15.5 1.0 0.0099 15.5 1.0 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 CCM01466.1 - 0.035 14.0 1.5 0.061 13.2 0.3 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCM01466.1 - 0.046 13.9 1.5 0.12 12.6 0.6 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 CCM01466.1 - 0.23 11.8 1.0 0.42 11.0 1.0 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 CCM01466.1 - 2 8.6 3.5 4.2 7.6 1.7 2.3 2 1 0 2 2 1 0 FANCL C-terminal domain Sensor PF13796.6 CCM01466.1 - 2.5 8.1 0.0 2.5 8.1 0.0 2.7 1 1 0 2 2 1 0 Putative sensor GTP_EFTU PF00009.27 CCM01467.1 - 2e-10 40.6 0.1 0.00016 21.3 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CCM01467.1 - 2.6e-09 37.4 0.8 2.6e-09 37.4 0.8 2.8 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 CCM01467.1 - 4.2e-05 23.8 0.0 0.00012 22.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain DUF4407 PF14362.6 CCM01468.1 - 4.4 6.6 14.1 6.9 5.9 14.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Glyco_hydro_18 PF00704.28 CCM01469.1 - 3e-84 283.4 0.3 4e-84 283.0 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PASTA PF03793.19 CCM01469.1 - 0.09 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 PASTA domain Pkinase PF00069.25 CCM01470.1 - 6.6e-42 143.7 0.0 1.8e-17 63.6 0.0 3.2 2 1 1 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01470.1 - 1.9e-16 60.1 0.0 2e-05 24.0 0.0 3.2 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase_C PF00433.24 CCM01470.1 - 0.24 12.2 1.4 0.98 10.2 0.0 2.8 3 0 0 3 3 3 0 Protein kinase C terminal domain Homeodomain PF00046.29 CCM01471.1 - 2.1e-16 59.5 6.2 3.8e-16 58.7 6.2 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCM01471.1 - 5e-05 23.1 0.3 5e-05 23.1 0.3 2.2 3 0 0 3 3 3 1 Homeobox KN domain ABC_tran PF00005.27 CCM01472.1 - 2.8e-48 163.9 0.0 4.6e-29 101.7 0.0 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCM01472.1 - 2.6e-13 50.4 0.1 7.2e-05 22.7 0.2 4.3 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM01472.1 - 2.9e-12 46.5 0.0 0.00039 19.9 0.0 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 CCM01472.1 - 2.9e-10 39.9 0.1 5.6e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 CCM01472.1 - 2e-07 31.7 0.0 0.0029 18.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CCM01472.1 - 1.2e-06 28.1 0.9 0.05 13.3 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 CCM01472.1 - 8.7e-06 25.9 0.0 0.0041 17.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCM01472.1 - 1.1e-05 25.4 0.0 0.04 14.0 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase NACHT PF05729.12 CCM01472.1 - 2.5e-05 24.2 0.1 0.0092 15.9 0.0 2.8 2 0 0 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 CCM01472.1 - 2.6e-05 24.2 0.1 0.062 13.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 CCM01472.1 - 3.1e-05 24.3 0.0 0.15 12.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CCM01472.1 - 3.2e-05 24.5 0.0 0.2 12.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 CCM01472.1 - 3.3e-05 24.1 0.0 0.39 10.8 0.0 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_22 PF13401.6 CCM01472.1 - 6e-05 23.3 0.3 0.93 9.8 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CCM01472.1 - 8e-05 23.1 1.9 0.62 10.4 0.0 3.7 4 0 0 4 4 3 2 AAA ATPase domain HEAT PF02985.22 CCM01472.1 - 0.00068 19.7 2.0 16 6.1 0.0 4.6 4 0 0 4 4 3 0 HEAT repeat AAA_24 PF13479.6 CCM01472.1 - 0.0014 18.4 0.0 1.7 8.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_13 PF13166.6 CCM01472.1 - 0.0017 17.1 0.0 1.1 7.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 CCM01472.1 - 0.0017 17.4 0.5 0.91 8.4 0.1 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 CCM01472.1 - 0.004 17.5 0.1 2.8 8.4 0.0 3.0 3 0 0 3 3 2 1 RNA helicase Roc PF08477.13 CCM01472.1 - 0.0079 16.4 0.0 5.4 7.3 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Tudor-knot PF11717.8 CCM01472.1 - 0.02 14.8 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain ATP_bind_1 PF03029.17 CCM01472.1 - 0.026 14.3 0.1 8.9 6.0 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 CCM01472.1 - 0.028 14.4 0.0 13 5.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_27 PF13514.6 CCM01472.1 - 0.03 13.9 0.0 1.9 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CCM01472.1 - 0.036 13.8 1.1 2.1 8.0 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain Ploopntkinase3 PF18751.1 CCM01472.1 - 0.037 13.9 0.1 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 CLASP_N PF12348.8 CCM01472.1 - 0.049 13.2 0.0 0.89 9.1 0.0 2.3 2 0 0 2 2 2 0 CLASP N terminal Arf PF00025.21 CCM01472.1 - 0.052 13.0 0.0 2.2 7.7 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family G-alpha PF00503.20 CCM01472.1 - 0.055 12.6 0.0 0.24 10.5 0.0 1.9 2 0 0 2 2 2 0 G-protein alpha subunit AAA_30 PF13604.6 CCM01472.1 - 0.065 12.9 4.0 7 6.3 0.0 3.5 4 0 0 4 4 3 0 AAA domain NB-ARC PF00931.22 CCM01472.1 - 0.1 11.8 0.0 11 5.1 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 CCM01472.1 - 0.12 11.8 0.0 3.7 7.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 CCM01472.1 - 0.13 11.9 0.0 3.1 7.4 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.19 CCM01472.1 - 0.13 11.8 0.3 18 4.9 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 CCM01472.1 - 0.14 11.9 0.0 13 5.6 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 CCM01472.1 - 0.17 11.8 0.2 36 4.2 0.0 3.2 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 CCM01472.1 - 0.17 11.9 0.7 17 5.4 0.1 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF3584 PF12128.8 CCM01472.1 - 0.2 9.1 1.8 3.8 4.9 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) HEAT_EZ PF13513.6 CCM01472.1 - 0.91 10.1 4.9 8.7 7.0 0.7 3.8 3 1 1 4 4 3 0 HEAT-like repeat zf-C2H2 PF00096.26 CCM01473.1 - 2.4e-15 56.0 5.2 1.5e-07 31.5 0.5 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM01473.1 - 5.4e-10 39.2 6.5 2.9e-05 24.3 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCM01473.1 - 3.3e-07 30.6 3.9 0.00015 22.3 0.3 2.7 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CCM01473.1 - 0.0013 18.6 3.2 0.033 14.1 0.1 2.4 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 CCM01473.1 - 0.0038 17.5 0.6 0.012 15.8 0.1 2.0 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CCM01473.1 - 0.0069 16.4 2.6 0.11 12.5 0.3 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger DUF3268 PF11672.8 CCM01473.1 - 0.014 15.8 0.5 0.025 14.9 0.5 1.4 1 0 0 1 1 1 0 zinc-finger-containing domain PyrI_C PF02748.15 CCM01473.1 - 0.063 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 CCM01473.1 - 0.064 13.0 5.8 2.2 8.1 0.6 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-met PF12874.7 CCM01473.1 - 0.11 12.9 1.4 0.25 11.8 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn_ribbon_SprT PF17283.2 CCM01473.1 - 0.24 11.3 4.1 5.1 7.1 1.5 2.5 1 1 1 2 2 2 0 SprT-like zinc ribbon domain zf-Di19 PF05605.12 CCM01473.1 - 0.68 10.3 7.0 0.12 12.7 0.7 2.6 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 CCM01473.1 - 5.5 6.8 11.5 4.2 7.2 0.5 3.2 2 1 0 2 2 2 0 C2H2-type zinc-finger domain BolA PF01722.18 CCM01474.1 - 8.1e-25 86.9 1.1 7e-24 83.9 1.1 2.0 1 1 0 1 1 1 1 BolA-like protein Pyrid_oxidase_2 PF13883.6 CCM01477.1 - 6.4e-18 65.3 0.0 8.1e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PTPLA PF04387.14 CCM01477.1 - 0.15 11.8 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA DNA_ligase_A_M PF01068.21 CCM01478.1 - 6e-42 143.6 0.0 1.7e-39 135.6 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCM01478.1 - 2.4e-35 122.4 0.0 1.3e-34 120.1 0.0 2.3 3 0 0 3 3 3 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CCM01478.1 - 6.3e-13 49.2 0.0 9e-10 39.0 0.0 3.2 4 0 0 4 4 4 2 ATP dependent DNA ligase C terminal region vATP-synt_E PF01991.18 CCM01478.1 - 0.17 11.2 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit zf-C2H2 PF00096.26 CCM01479.1 - 3.3e-12 46.1 6.9 3.4e-06 27.2 0.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM01479.1 - 2.5e-08 34.0 5.7 9.5e-07 29.0 0.3 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCM01479.1 - 1.9e-07 31.3 5.6 0.011 16.6 1.8 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCM01479.1 - 0.00025 21.2 1.4 0.022 15.0 0.3 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM01479.1 - 0.001 19.4 1.2 1.1 9.7 0.6 2.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 CCM01479.1 - 0.0028 17.4 0.8 2.3 8.0 0.0 2.4 2 0 0 2 2 2 2 zinc-finger C2H2-type BolA PF01722.18 CCM01479.1 - 0.0054 17.0 0.0 3.3 8.1 0.0 2.1 2 0 0 2 2 2 2 BolA-like protein zf-C2H2_6 PF13912.6 CCM01479.1 - 0.0078 16.2 3.1 0.49 10.5 0.8 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 CCM01479.1 - 0.052 14.2 2.1 0.13 12.9 0.3 1.9 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-MYST PF17772.1 CCM01479.1 - 0.5 10.0 2.0 1.8 8.2 0.4 2.1 1 1 1 2 2 2 0 MYST family zinc finger domain zf-AN1 PF01428.16 CCM01479.1 - 6.4 7.0 7.4 4.2 7.6 1.8 2.3 1 1 1 2 2 2 0 AN1-like Zinc finger Acetyltransf_1 PF00583.25 CCM01480.1 - 1.9e-11 44.2 0.0 2.4e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM01480.1 - 6.4e-06 26.1 0.0 8.5e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM01480.1 - 1.7e-05 25.2 0.0 2.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM01480.1 - 0.046 13.7 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_4 PF13420.7 CCM01480.1 - 0.097 12.8 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Complex1_49kDa PF00346.19 CCM01480.1 - 0.11 11.6 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit ClpB_D2-small PF10431.9 CCM01481.1 - 0.025 14.6 0.0 2.6 8.2 0.0 2.3 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Asp PF00026.23 CCM01482.1 - 2.2e-43 148.9 0.5 6.5e-43 147.3 0.5 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM01482.1 - 3e-06 27.6 0.4 8.5e-05 22.9 0.4 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CCM01482.1 - 0.086 12.6 0.0 0.23 11.2 0.0 1.7 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Cyclin PF08613.11 CCM01483.1 - 0.0023 18.3 0.0 0.0067 16.8 0.0 1.7 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CCM01483.1 - 0.007 16.1 0.0 0.025 14.3 0.0 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Fungal_trans_2 PF11951.8 CCM01484.1 - 1.7e-45 155.5 0.0 2e-45 155.3 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM01485.1 - 9.9e-08 32.0 8.9 1.6e-07 31.4 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-SNAP50_C PF12251.8 CCM01486.1 - 4.5e-17 62.4 0.0 7.3e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal PTS_2-RNA PF01885.16 CCM01486.1 - 0.11 12.5 0.4 0.31 11.1 0.4 1.7 1 1 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Asparaginase_2 PF01112.18 CCM01487.1 - 1e-32 113.4 0.0 1.8e-32 112.6 0.0 1.4 1 1 0 1 1 1 1 Asparaginase RNase_H2-Ydr279 PF09468.10 CCM01488.1 - 3.6e-20 72.7 0.8 5.2e-20 72.2 0.0 1.7 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 CCM01488.1 - 2.3e-14 53.4 0.0 6.9e-14 51.9 0.0 1.8 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain EIIBC-GUT_N PF03612.14 CCM01488.1 - 0.055 13.2 0.6 0.094 12.5 0.6 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pkinase PF00069.25 CCM01490.1 - 7.7e-66 222.1 0.0 9.1e-66 221.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01490.1 - 7.8e-37 126.9 0.0 1e-36 126.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM01490.1 - 3.7e-05 23.2 0.0 0.00053 19.4 0.0 2.3 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CCM01490.1 - 7.4e-05 21.7 0.0 0.00011 21.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 CCM01490.1 - 0.088 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Slu7 PF11708.8 CCM01491.1 - 6.4e-110 367.1 14.6 6.4e-110 367.1 14.6 1.9 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 CCM01491.1 - 0.089 12.5 0.2 0.17 11.6 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF1771 PF08590.10 CCM01492.1 - 0.00012 22.3 4.7 0.00025 21.3 4.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) SNF2_N PF00176.23 CCM01493.1 - 3.2e-60 203.7 0.4 6.4e-60 202.7 0.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4208 PF13907.6 CCM01493.1 - 7.5e-24 84.0 0.3 3.4e-23 81.9 0.3 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 CCM01493.1 - 1e-19 70.9 0.0 3.3e-19 69.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 CCM01493.1 - 2.7e-17 62.4 7.7 3.3e-13 49.3 1.0 3.1 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 CCM01493.1 - 5.3e-09 36.3 0.0 3.1e-08 33.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 CCM01493.1 - 1.2e-07 32.1 0.9 1.2e-07 32.1 0.9 4.0 3 1 0 3 3 3 1 Chromodomain helicase DNA-binding domain 1 CDH1_2_SANT_HL1 PF18375.1 CCM01493.1 - 0.00044 20.9 2.3 0.0011 19.6 0.2 2.9 2 0 0 2 2 2 1 CDH1/2 SANT-Helical linker 1 FlhC PF05280.11 CCM01493.1 - 0.08 12.7 0.1 0.25 11.1 0.1 1.8 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) Asp PF00026.23 CCM01494.1 - 1.9e-21 76.8 5.6 7.5e-18 65.0 5.6 3.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CCM01494.1 - 2.1e-05 25.0 2.4 0.00014 22.4 0.6 2.9 2 2 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CCM01494.1 - 7e-05 23.3 1.1 0.0084 16.6 0.1 3.4 3 1 0 3 3 3 1 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 CCM01494.1 - 0.00069 19.9 0.9 0.2 11.9 0.1 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal ATP-sulfurylase PF01747.17 CCM01495.1 - 1.4e-88 295.9 0.2 1.9e-88 295.4 0.2 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 CCM01495.1 - 3.8e-55 185.9 0.0 9.8e-55 184.6 0.0 1.7 2 0 0 2 2 2 1 PUA-like domain APS_kinase PF01583.20 CCM01495.1 - 6.5e-45 152.8 0.0 9.8e-45 152.3 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 CCM01495.1 - 0.0025 18.3 0.0 0.0055 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 CCM01495.1 - 0.0041 16.6 0.0 0.0068 15.9 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 CPT PF07931.12 CCM01495.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ERO1 PF04137.15 CCM01496.1 - 5.6e-127 423.8 0.0 6.7e-127 423.5 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) ShK PF01549.24 CCM01496.1 - 0.041 14.4 0.3 0.15 12.6 0.3 1.9 1 0 0 1 1 1 0 ShK domain-like DUF2700 PF10912.8 CCM01497.1 - 0.048 13.7 0.0 0.086 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2700) KH_1 PF00013.29 CCM01498.1 - 3.4e-82 270.2 36.0 1.2e-11 44.2 0.5 13.5 12 2 0 12 12 12 10 KH domain KH_2 PF07650.17 CCM01498.1 - 1.3e-05 24.9 27.5 0.15 11.9 0.0 8.3 8 1 0 8 8 8 4 KH domain SLS PF14611.6 CCM01498.1 - 1.8e-05 24.7 15.0 0.21 11.4 0.1 6.6 7 2 2 9 9 9 4 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.6 CCM01498.1 - 0.00082 19.2 2.9 4.5 7.2 0.2 4.9 4 0 0 4 4 4 2 KH domain MOEP19 PF16005.5 CCM01498.1 - 0.0061 16.5 0.1 2.4 8.2 0.0 4.1 4 0 0 4 4 4 1 KH-like RNA-binding domain RRM_1 PF00076.22 CCM01499.1 - 2.6e-11 43.2 0.0 0.00013 21.8 0.0 2.7 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Surp PF01805.20 CCM01499.1 - 5.6e-09 35.9 0.2 1.5e-08 34.5 0.2 1.7 1 0 0 1 1 1 1 Surp module CTD_bind PF04818.13 CCM01499.1 - 0.013 16.3 0.0 0.03 15.1 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase II-binding domain. RRM_7 PF16367.5 CCM01499.1 - 0.11 12.6 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif Metallophos PF00149.28 CCM01500.1 - 0.035 14.6 0.0 0.05 14.1 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase PPP5 PF08321.12 CCM01501.1 - 1.3e-28 99.1 0.0 6.3e-28 96.9 0.0 2.0 2 0 0 2 2 2 1 PPP5 TPR repeat region Metallophos PF00149.28 CCM01501.1 - 5.1e-18 66.3 0.0 9.3e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 CCM01501.1 - 1.5e-15 56.3 8.7 1.1e-07 31.3 1.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM01501.1 - 1.3e-12 47.2 3.1 4.9e-05 22.9 0.0 3.6 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.17 CCM01501.1 - 8.6e-12 44.2 10.6 1.9e-06 27.5 0.9 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCM01501.1 - 6.4e-10 38.7 4.5 0.0011 19.1 0.0 3.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01501.1 - 6.6e-09 35.3 5.1 8e-05 22.6 0.5 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM01501.1 - 1.4e-07 31.9 2.0 0.0017 18.8 0.8 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCM01501.1 - 1.6e-07 31.3 0.1 0.0028 17.7 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM01501.1 - 2.1e-06 28.3 0.6 0.017 15.8 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM01501.1 - 5.3e-06 26.8 2.5 0.058 14.2 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCM01501.1 - 0.00038 20.9 3.5 0.002 18.6 1.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM01501.1 - 0.029 14.6 1.8 0.029 14.6 1.8 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CCM01501.1 - 0.066 13.5 4.8 0.4 11.0 1.9 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.12 CCM01501.1 - 0.12 13.1 0.3 43 5.0 0.0 3.2 3 0 0 3 3 2 0 Sel1 repeat Allantoicase PF03561.15 CCM01502.1 - 1.6e-90 300.5 0.0 1.1e-45 155.2 0.0 2.7 3 0 0 3 3 3 2 Allantoicase repeat IF-2B PF01008.17 CCM01502.1 - 2e-56 191.3 0.0 2.6e-56 190.9 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Ureidogly_lyase PF04115.12 CCM01502.1 - 1.7e-49 168.2 0.0 4.3e-49 166.8 0.0 1.6 1 0 0 1 1 1 1 Ureidoglycolate lyase ABC_tran PF00005.27 CCM01503.1 - 3.8e-46 157.0 0.2 3.5e-27 95.6 0.1 2.8 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCM01503.1 - 4.3e-45 154.5 23.9 6.4e-23 81.8 3.0 3.6 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 CCM01503.1 - 8e-12 45.1 6.1 0.0092 15.4 0.6 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM01503.1 - 4.4e-08 33.9 2.0 0.00021 21.9 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 CCM01503.1 - 4.1e-07 30.1 7.3 0.0048 16.7 0.2 5.1 3 2 2 5 5 5 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM01503.1 - 1.2e-06 28.2 0.4 0.0093 15.7 0.0 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM01503.1 - 3.2e-06 27.6 0.3 0.14 12.5 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CCM01503.1 - 0.00011 21.9 0.0 0.41 10.2 0.0 2.7 3 0 0 3 3 2 2 AAA domain T2SSE PF00437.20 CCM01503.1 - 0.00025 20.2 0.1 0.047 12.7 0.0 2.6 3 0 0 3 3 3 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 CCM01503.1 - 0.00036 20.6 0.1 0.41 10.7 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM01503.1 - 0.00058 19.8 0.3 0.35 10.8 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CCM01503.1 - 0.00059 20.1 0.5 0.92 9.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 CCM01503.1 - 0.0007 19.0 0.1 0.32 10.3 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family DUF87 PF01935.17 CCM01503.1 - 0.00078 19.6 1.2 0.061 13.4 0.2 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_7 PF12775.7 CCM01503.1 - 0.0043 16.6 0.1 1.5 8.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 CCM01503.1 - 0.0064 16.5 0.3 9.2 6.3 0.1 3.8 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) Pox_A32 PF04665.12 CCM01503.1 - 0.0086 15.6 0.3 2.9 7.3 0.0 2.5 2 0 0 2 2 2 1 Poxvirus A32 protein IstB_IS21 PF01695.17 CCM01503.1 - 0.01 15.6 0.5 9.1 6.0 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein ATPase_2 PF01637.18 CCM01503.1 - 0.014 15.4 0.0 1 9.3 0.0 2.7 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea Adeno_IVa2 PF02456.15 CCM01503.1 - 0.029 13.2 0.1 0.51 9.1 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein ResIII PF04851.15 CCM01503.1 - 0.041 13.9 0.0 1.8 8.6 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TrwB_AAD_bind PF10412.9 CCM01503.1 - 0.057 12.3 0.4 6.7 5.5 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DEAD PF00270.29 CCM01503.1 - 0.059 13.1 0.4 18 5.1 0.2 2.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_18 PF13238.6 CCM01503.1 - 0.059 13.9 0.0 23 5.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CCM01503.1 - 0.1 12.7 1.3 7.1 6.7 0.0 3.2 3 0 0 3 3 3 0 Dynamin family PduV-EutP PF10662.9 CCM01503.1 - 0.12 12.2 0.6 3.7 7.3 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 CCM01503.1 - 0.13 11.7 0.0 4.5 6.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.22 CCM01503.1 - 0.14 12.6 0.2 16 5.9 0.0 2.8 3 0 0 3 3 2 0 RNA helicase AAA PF00004.29 CCM01503.1 - 0.14 12.6 0.7 2.1 8.8 0.0 3.1 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CCM01503.1 - 0.15 11.7 0.0 18 5.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CCM01503.1 - 0.16 12.2 0.2 20 5.4 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 CCM01503.1 - 0.19 11.4 3.3 0.25 11.0 0.0 2.4 3 0 0 3 3 2 0 AAA ATPase domain MWFE PF15879.5 CCM01503.1 - 0.36 11.0 0.0 0.36 11.0 0.0 3.0 3 0 0 3 3 2 0 NADH-ubiquinone oxidoreductase MWFE subunit cobW PF02492.19 CCM01503.1 - 0.94 9.0 3.4 2.3 7.8 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.6 CCM01503.1 - 2.2 8.0 5.5 0.44 10.3 0.1 2.6 4 1 0 4 4 2 0 AAA domain NACHT PF05729.12 CCM01503.1 - 9.4 6.1 7.6 7.2 6.5 0.1 3.3 4 0 0 4 4 3 0 NACHT domain ABC_tran PF00005.27 CCM01505.1 - 3e-08 34.3 0.0 4.8e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCM01505.1 - 3e-05 24.0 0.1 3.4e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM01505.1 - 0.0042 16.6 0.0 0.005 16.3 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CCM01505.1 - 0.086 13.1 0.4 1.3 9.3 0.4 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit GATA PF00320.27 CCM01506.1 - 1.9e-15 56.2 3.8 3.6e-15 55.3 3.8 1.5 1 0 0 1 1 1 1 GATA zinc finger TauD PF02668.16 CCM01507.1 - 6.4e-45 154.0 0.1 6.4e-45 154.0 0.1 1.6 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family Mito_fiss_reg PF05308.11 CCM01507.1 - 1.1 9.3 2.8 1.6 8.7 2.8 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator XRN_N PF03159.18 CCM01508.1 - 5.9e-94 314.0 0.0 1.1e-93 313.2 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CCM01508.1 - 3.4e-88 296.5 10.5 2.2e-87 293.9 10.5 2.2 1 1 0 1 1 1 1 Xrn1 helical domain XRN1_D1 PF18332.1 CCM01508.1 - 4.5e-75 251.6 0.0 8.9e-75 250.7 0.0 1.5 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain GMP_synt_C PF00958.22 CCM01508.1 - 2.2e-45 152.7 0.1 4.2e-45 151.7 0.1 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 CCM01508.1 - 2.8e-34 118.5 0.0 5.7e-34 117.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I XRN1_D2_D3 PF18334.1 CCM01508.1 - 3.2e-31 107.4 0.1 8e-31 106.1 0.1 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 CCM01508.1 - 6.2e-16 58.3 0.5 1.6e-15 56.9 0.5 1.8 1 0 0 1 1 1 1 Xrn1 SH3-like domain NAD_synthase PF02540.17 CCM01508.1 - 3.4e-09 36.2 0.2 3e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CCM01508.1 - 4.4e-07 29.9 0.0 8.9e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 Xrn1_D3 PF18194.1 CCM01508.1 - 6.2e-06 26.2 0.1 1.6e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 ThiI PF02568.14 CCM01508.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 CCM01508.1 - 0.015 14.1 0.1 0.025 13.4 0.1 1.3 1 0 0 1 1 1 0 tRNA methyl transferase Sterile PF03015.19 CCM01508.1 - 0.02 15.1 0.1 0.09 13.0 0.0 2.1 2 0 0 2 2 1 0 Male sterility protein QueC PF06508.13 CCM01508.1 - 0.079 12.4 0.0 0.21 11.0 0.0 1.6 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Amidase PF01425.21 CCM01509.1 - 1.3e-83 281.5 0.8 6e-82 276.0 0.8 2.1 1 1 0 1 1 1 1 Amidase PrpF PF04303.13 CCM01510.1 - 1.6e-73 247.8 0.9 2.5e-73 247.2 0.9 1.3 1 0 0 1 1 1 1 PrpF protein Lon_C PF05362.13 CCM01511.1 - 1e-70 237.4 0.2 1.7e-70 236.8 0.2 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CCM01511.1 - 2.7e-36 125.4 0.2 5.4e-36 124.4 0.2 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CCM01511.1 - 3e-21 76.2 0.0 8.7e-21 74.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 CCM01511.1 - 9e-08 32.0 0.1 2e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 CCM01511.1 - 1.1e-07 32.0 0.0 2.1e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCM01511.1 - 5.1e-06 26.7 0.0 1.7e-05 25.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_PrkA PF08298.11 CCM01511.1 - 8.4e-05 21.6 0.0 0.00017 20.6 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 CCM01511.1 - 0.00027 21.3 0.0 0.0011 19.4 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CCM01511.1 - 0.00031 20.5 0.0 0.001 18.8 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCM01511.1 - 0.00063 20.3 0.7 0.0015 19.1 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCM01511.1 - 0.00078 19.7 0.0 0.011 16.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CCM01511.1 - 0.0039 17.2 0.0 0.018 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCM01511.1 - 0.01 16.2 0.0 0.12 12.8 0.0 2.4 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 CCM01511.1 - 0.018 14.8 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CCM01511.1 - 0.023 13.9 0.1 0.069 12.3 0.1 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain NTPase_1 PF03266.15 CCM01511.1 - 0.032 14.1 0.1 0.22 11.4 0.0 2.3 2 1 1 3 3 2 0 NTPase SKI PF01202.22 CCM01511.1 - 0.036 14.2 0.3 0.095 12.8 0.0 1.9 2 0 0 2 2 1 0 Shikimate kinase AAA_28 PF13521.6 CCM01511.1 - 0.065 13.5 0.0 13 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CCM01511.1 - 0.073 12.9 0.0 0.3 11.0 0.0 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SPX PF03105.19 CCM01511.1 - 0.074 13.0 0.2 9.4 6.0 0.0 2.4 2 0 0 2 2 2 0 SPX domain RsgA_GTPase PF03193.16 CCM01511.1 - 0.08 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 CCM01511.1 - 0.087 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCM01511.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 CCM01511.1 - 0.15 11.8 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CCM01511.1 - 0.16 11.9 2.3 9.1 6.1 0.0 3.2 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea Cyt-b5 PF00173.28 CCM01512.1 - 1.5e-17 63.5 0.0 2.2e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Pkinase PF00069.25 CCM01514.1 - 5e-07 29.3 0.0 1.2e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01514.1 - 0.00095 18.5 0.0 0.0018 17.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase AMP-binding PF00501.28 CCM01516.1 - 1.3e-32 112.9 0.1 8e-29 100.5 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme NAD_binding_4 PF07993.12 CCM01516.1 - 8.3e-27 94.0 0.0 1.4e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCM01516.1 - 1.6e-10 40.9 0.0 6.1e-10 39.0 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM01516.1 - 0.12 11.7 0.0 0.29 10.5 0.0 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF3262 PF11660.8 CCM01517.1 - 0.027 14.8 5.0 0.027 14.8 5.0 4.4 4 1 1 5 5 5 0 Protein of unknown function (DUF3262) SHR3_chaperone PF08229.11 CCM01517.1 - 6.5 5.7 8.3 1.7 7.6 4.0 2.3 2 1 0 2 2 2 0 ER membrane protein SH3 RPE65 PF03055.15 CCM01518.1 - 8.1e-106 355.0 0.0 9.3e-106 354.8 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein MIF4G PF02854.19 CCM01519.1 - 9.1e-26 90.8 1.2 3.8e-25 88.8 1.2 1.9 1 1 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 CCM01519.1 - 6.2e-16 58.3 0.0 1.3e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 Barttin PF15462.6 CCM01519.1 - 0.021 14.6 0.2 0.046 13.5 0.2 1.5 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) F-box-like PF12937.7 CCM01520.1 - 0.0079 16.1 3.4 0.022 14.6 3.4 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01520.1 - 0.045 13.6 0.4 0.045 13.6 0.4 2.6 2 0 0 2 2 2 0 F-box domain Glyco_hydro_28 PF00295.17 CCM01521.1 - 9.5e-41 139.9 10.9 1.4e-40 139.4 10.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pkinase PF00069.25 CCM01524.1 - 1.5e-08 34.3 0.0 8e-07 28.7 0.0 2.6 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01524.1 - 4.2e-05 23.0 0.0 0.00017 20.9 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Ferredoxin_N PF16947.5 CCM01524.1 - 0.11 12.7 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 N-terminal region of 4Fe-4S ferredoxin iron-sulfur binding Pkinase_fungal PF17667.1 CCM01524.1 - 0.22 10.3 0.0 0.29 9.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase ABC_tran PF00005.27 CCM01526.1 - 8.6e-29 100.8 0.0 1.9e-16 60.8 0.0 3.1 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCM01526.1 - 0.00015 21.7 0.2 1.5 8.5 0.0 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM01526.1 - 0.0014 18.3 0.0 0.034 13.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CCM01526.1 - 0.014 15.3 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CCM01526.1 - 0.16 12.3 0.1 0.87 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.8 CCM01526.1 - 0.32 8.5 0.0 0.43 8.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Peptidase_M28 PF04389.17 CCM01529.1 - 6e-29 101.2 0.0 1.1e-28 100.2 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCM01529.1 - 0.004 16.9 0.0 0.0088 15.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 CCM01529.1 - 0.15 11.0 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase DUF3669 PF12417.8 CCM01529.1 - 0.18 12.0 0.0 0.57 10.4 0.0 1.8 1 0 0 1 1 1 0 Zinc finger protein DUF4923 PF16270.5 CCM01529.1 - 0.2 11.5 0.0 0.6 9.9 0.0 1.7 1 1 1 2 2 2 0 Lipocalin-like domain (DUF4923) NrsF PF06532.11 CCM01529.1 - 0.33 10.7 19.0 0.028 14.1 9.0 2.8 2 0 0 2 2 2 0 Negative regulator of sigma F adh_short PF00106.25 CCM01530.1 - 3.9e-39 134.1 2.8 5.4e-39 133.7 2.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01530.1 - 1.1e-33 116.8 2.9 1.7e-33 116.1 2.9 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01530.1 - 6.5e-15 55.5 1.2 9.7e-15 54.9 1.2 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCM01530.1 - 0.00016 20.9 0.4 0.00026 20.2 0.4 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCM01530.1 - 0.0002 20.9 0.4 0.00037 20.0 0.4 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 CCM01530.1 - 0.028 14.2 0.2 0.085 12.6 0.2 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.19 CCM01530.1 - 0.052 12.9 0.4 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TcA_RBD PF18518.1 CCM01531.1 - 0.0059 16.9 0.1 24 5.2 0.0 3.4 3 0 0 3 3 3 1 TcA receptor binding domain Coagulase PF08764.10 CCM01531.1 - 0.054 13.7 4.0 24 5.0 0.1 3.3 3 0 0 3 3 3 0 Staphylococcus aureus coagulase DUF2458 PF10454.9 CCM01531.1 - 0.067 12.8 0.1 40 3.8 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2458) DUF3482 PF11981.8 CCM01531.1 - 0.53 9.6 5.7 4.8 6.5 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3482) adh_short PF00106.25 CCM01532.1 - 1.7e-41 141.9 1.9 2.2e-41 141.4 1.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01532.1 - 1.3e-38 132.9 2.0 1.7e-38 132.5 2.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01532.1 - 8.9e-15 55.0 1.3 1.2e-14 54.6 1.3 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCM01532.1 - 1.1e-05 24.7 0.1 1.5e-05 24.3 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCM01532.1 - 7.1e-05 22.4 1.3 0.00019 21.0 1.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 CCM01532.1 - 0.059 13.1 0.3 0.22 11.3 0.1 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase HEAT_2 PF13646.6 CCM01533.1 - 7.3e-36 122.4 2.0 2.9e-16 59.6 0.0 3.8 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.16 CCM01533.1 - 2.6e-23 80.3 0.5 0.00061 20.2 0.0 6.8 7 0 0 7 7 7 4 PBS lyase HEAT-like repeat HEAT PF02985.22 CCM01533.1 - 6.9e-12 44.6 1.3 0.029 14.6 0.0 5.7 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 CCM01533.1 - 5.4e-05 23.6 4.0 2.2 8.9 0.1 5.6 5 2 1 6 6 6 2 HEAT-like repeat Arm PF00514.23 CCM01533.1 - 0.00017 21.5 0.3 0.12 12.4 0.1 2.9 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 CCM01533.1 - 0.034 14.2 0.0 0.73 9.9 0.0 2.9 2 2 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 CCM01533.1 - 0.087 13.2 0.0 1.5 9.2 0.0 2.9 3 1 1 4 4 4 0 TAF6 C-terminal HEAT repeat domain RTBV_P12 PF06361.11 CCM01533.1 - 0.12 12.7 0.0 1.6 9.2 0.0 2.1 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein RL10P_insert PF17777.1 CCM01534.1 - 1.1e-22 79.8 0.0 2.1e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 CCM01534.1 - 3e-22 78.7 0.0 4.3e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 RRF PF01765.19 CCM01534.1 - 0.003 17.5 0.9 0.006 16.6 0.3 1.7 2 0 0 2 2 2 1 Ribosome recycling factor adh_short PF00106.25 CCM01536.1 - 1.3e-39 135.7 1.4 1.9e-39 135.2 1.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01536.1 - 1.7e-36 126.0 1.5 2.7e-36 125.3 1.5 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01536.1 - 2e-11 44.1 0.9 2.8e-11 43.7 0.9 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 CCM01536.1 - 0.011 15.4 0.3 0.028 14.2 0.1 1.7 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Polysacc_synt_2 PF02719.15 CCM01536.1 - 0.021 13.9 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 CCM01537.1 - 1.2e-37 129.3 1.3 1.5e-37 129.0 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01537.1 - 4.1e-36 124.7 1.6 7.9e-36 123.8 1.6 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01537.1 - 4.3e-14 52.8 1.5 6.2e-14 52.3 1.5 1.3 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CCM01537.1 - 0.0074 15.6 0.5 0.26 10.6 0.3 2.8 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 CCM01537.1 - 0.019 14.3 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.8 CCM01537.1 - 0.046 13.5 0.1 0.097 12.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.21 CCM01537.1 - 0.064 12.7 0.5 0.11 11.9 0.5 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCM01537.1 - 0.071 12.2 0.1 0.094 11.8 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 CCM01538.1 - 3.4e-43 147.4 1.5 4.7e-43 146.9 1.5 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01538.1 - 5.8e-38 130.8 1.4 1e-37 130.0 1.4 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01538.1 - 2.9e-14 53.4 1.0 4.2e-14 52.9 1.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM01538.1 - 9.7e-06 25.2 0.5 2.4e-05 23.9 0.5 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PA PF02225.22 CCM01538.1 - 0.0021 18.0 0.2 0.004 17.1 0.2 1.4 1 0 0 1 1 1 1 PA domain Polysacc_synt_2 PF02719.15 CCM01538.1 - 0.0026 16.9 0.2 0.0042 16.2 0.2 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 CCM01538.1 - 0.0035 17.1 0.3 0.0068 16.2 0.3 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1776 PF08643.10 CCM01538.1 - 0.095 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) AdoHcyase PF05221.17 CCM01538.1 - 0.1 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase THF_DHG_CYH_C PF02882.19 CCM01538.1 - 0.12 11.7 1.6 0.33 10.3 0.1 2.2 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain adh_short PF00106.25 CCM01539.1 - 2.8e-36 124.8 1.6 3.6e-36 124.4 1.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01539.1 - 2.2e-33 115.8 0.8 2.8e-33 115.4 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM01539.1 - 7.9e-12 45.5 0.4 1.1e-11 44.9 0.4 1.3 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 CCM01539.1 - 0.03 14.1 0.2 0.058 13.2 0.2 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Polysacc_synt_2 PF02719.15 CCM01539.1 - 0.073 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Peptidase_S28 PF05577.12 CCM01542.1 - 6.2e-47 160.4 3.6 4.4e-46 157.6 3.6 1.9 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 CCM01542.1 - 0.025 14.1 0.2 0.088 12.3 0.2 1.7 1 1 1 2 2 2 0 Prolyl oligopeptidase family Peptidase_S37 PF05576.11 CCM01542.1 - 0.13 11.0 1.4 2.1 6.9 0.0 2.2 2 0 0 2 2 2 0 PS-10 peptidase S37 Adaptin_binding PF10199.9 CCM01544.1 - 7.6e-09 36.2 7.2 1.5e-07 32.0 7.2 2.2 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Methyltransf_25 PF13649.6 CCM01546.1 - 1.1e-15 58.1 0.0 2.1e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM01546.1 - 9.4e-13 48.6 0.0 1.8e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM01546.1 - 5.5e-09 36.0 0.0 1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM01546.1 - 1e-08 35.2 0.0 1.9e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM01546.1 - 7.1e-08 32.1 0.0 1.1e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CCM01546.1 - 5.9e-06 26.9 0.0 1.2e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CCM01546.1 - 0.0008 19.6 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CCM01546.1 - 0.026 14.0 0.0 0.072 12.5 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.14 CCM01546.1 - 0.065 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_29 PF03141.16 CCM01546.1 - 0.21 10.1 0.0 0.36 9.3 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.20 CCM01546.1 - 0.25 10.6 0.0 0.4 9.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Nup84_Nup100 PF04121.13 CCM01547.1 - 2.6e-157 525.1 0.0 3e-157 524.9 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Arg_decarbox_C PF17944.1 CCM01547.1 - 0.026 15.1 1.9 4 8.1 0.0 3.7 4 0 0 4 4 4 0 Arginine decarboxylase C-terminal helical extension TPR_14 PF13428.6 CCM01547.1 - 0.34 11.9 0.1 0.34 11.9 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PLDc PF00614.22 CCM01548.1 - 7.2e-18 64.0 2.0 7.4e-09 35.4 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 CCM01548.1 - 6.5e-16 58.4 0.3 1.2e-06 28.5 0.0 3.4 3 0 0 3 3 3 3 PLD-like domain DUF3916 PF13079.6 CCM01548.1 - 0.089 12.7 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3916) ADH_N_2 PF16884.5 CCM01549.1 - 2.3e-24 85.4 0.0 3.9e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CCM01549.1 - 1.1e-18 67.4 0.0 1.7e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM01549.1 - 3.1e-05 25.0 0.0 7e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 CCM01549.1 - 0.015 15.1 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase adh_short PF00106.25 CCM01549.1 - 0.037 13.5 0.2 0.053 13.0 0.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_10 PF13460.6 CCM01549.1 - 0.086 12.7 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 CCM01549.1 - 0.16 11.4 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCM01549.1 - 0.17 11.0 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain ADH_N_2 PF16884.5 CCM01550.1 - 3.4e-25 88.0 0.0 5.6e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CCM01550.1 - 4.8e-18 65.4 0.1 7.8e-18 64.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM01550.1 - 1.4e-05 26.1 0.0 3.2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 CCM01550.1 - 0.04 13.6 0.1 0.061 13.0 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Transport_MerF PF11431.8 CCM01550.1 - 0.049 13.5 0.7 0.14 12.1 0.7 1.7 1 0 0 1 1 1 0 Membrane transport protein MerF PARP PF00644.20 CCM01551.1 - 6.5e-12 45.4 0.1 1.3e-11 44.4 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 CCM01551.1 - 1.8e-05 24.4 0.0 4.2e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCM01551.1 - 0.087 13.1 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 RWD domain Solute_trans_a PF03619.16 CCM01552.1 - 1.9e-75 253.8 17.0 2.3e-75 253.6 17.0 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Glycos_transf_4 PF00953.21 CCM01552.1 - 0.87 9.5 7.9 0.16 11.9 1.2 2.5 2 1 0 2 2 2 0 Glycosyl transferase family 4 Adeno_E4_34 PF04528.13 CCM01554.1 - 0.012 15.4 3.9 0.023 14.5 3.9 1.4 1 0 0 1 1 1 0 Adenovirus early E4 34 kDa protein conserved region Macro_2 PF14519.6 CCM01555.1 - 0.099 12.0 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Macro-like domain AMP-binding PF00501.28 CCM01556.1 - 4.3e-65 219.9 0.0 1.1e-32 113.3 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CCM01556.1 - 2.7e-15 57.1 0.8 8.9e-15 55.4 0.4 2.2 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Pectate_lyase_3 PF12708.7 CCM01557.1 - 2.7e-16 60.1 1.9 6.5e-12 45.7 0.2 2.5 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCM01557.1 - 0.037 13.7 0.0 0.08 12.6 0.0 1.6 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase VRR_NUC PF08774.11 CCM01558.1 - 9.6e-26 90.0 0.0 2.5e-25 88.6 0.0 1.7 1 0 0 1 1 1 1 VRR-NUC domain WD40 PF00400.32 CCM01559.1 - 0.0017 19.1 1.5 3.9 8.5 0.0 4.3 3 1 1 4 4 4 1 WD domain, G-beta repeat Macoilin PF09726.9 CCM01559.1 - 0.012 14.3 1.4 0.014 14.0 0.0 1.8 2 1 0 2 2 2 0 Macoilin family TSC22 PF01166.18 CCM01559.1 - 0.02 15.2 1.3 0.041 14.2 1.3 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family BBS2_N PF14781.6 CCM01559.1 - 0.03 14.2 0.5 2.8 7.9 0.0 3.5 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal ZapB PF06005.12 CCM01559.1 - 0.08 13.4 0.6 0.16 12.5 0.6 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF5595 PF18077.1 CCM01559.1 - 0.1 12.7 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) PIN_2 PF10130.9 CCM01559.1 - 0.13 12.5 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 PIN domain Pam17 PF08566.10 CCM01562.1 - 6.5e-59 198.5 0.0 9.4e-39 132.9 0.1 2.1 1 1 1 2 2 2 2 Mitochondrial import protein Pam17 DUF3429 PF11911.8 CCM01563.1 - 2.7e-39 134.7 16.4 3.5e-39 134.4 16.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) DUF5585 PF17823.1 CCM01563.1 - 0.07 12.1 0.7 0.11 11.5 0.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5585) AAA_5 PF07728.14 CCM01564.1 - 1.6e-11 44.3 0.0 3.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCM01564.1 - 4.7e-07 30.1 0.0 8.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CCM01564.1 - 6.8e-06 26.5 0.0 1.4e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM01564.1 - 1e-05 26.0 0.4 0.00042 20.7 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CCM01564.1 - 8.8e-05 22.8 0.0 0.00028 21.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCM01564.1 - 0.012 15.0 0.1 0.085 12.2 0.1 2.1 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CCM01564.1 - 0.013 15.9 0.0 0.049 14.0 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 CCM01564.1 - 0.023 14.4 0.0 0.045 13.5 0.0 1.5 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 CCM01564.1 - 0.043 13.8 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCM01564.1 - 0.048 13.2 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 CCM01564.1 - 0.099 12.8 0.1 0.35 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Aha1_N PF09229.11 CCM01566.1 - 9.3e-31 106.9 0.0 1.3e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 CCM01566.1 - 7.2e-14 52.1 0.1 1.5e-13 51.0 0.1 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Pkinase PF00069.25 CCM01568.1 - 1.5e-70 237.6 0.0 2.2e-70 237.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01568.1 - 3.7e-47 160.8 0.0 5.4e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM01568.1 - 0.00059 18.7 0.1 0.0015 17.4 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCM01568.1 - 0.001 18.4 0.0 0.008 15.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CCM01568.1 - 0.046 13.1 0.0 0.089 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1682 PF07946.14 CCM01569.1 - 2e-91 306.6 0.0 2.2e-91 306.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) RNA_pol_Rpc4 PF05132.14 CCM01569.1 - 0.23 11.9 2.4 0.36 11.3 2.4 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 CCM01569.1 - 7.3 6.3 11.3 11 5.8 11.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3818 PF12825.7 CCM01571.1 - 3e-133 444.1 0.2 3.9e-133 443.7 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 CCM01571.1 - 6.4e-33 113.5 0.4 1.3e-32 112.5 0.4 1.5 1 0 0 1 1 1 1 PX-associated PX PF00787.24 CCM01571.1 - 5e-12 45.8 0.2 1.9e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 PX domain TPR_7 PF13176.6 CCM01571.1 - 0.086 12.9 0.1 0.37 10.9 0.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3851 PF12962.7 CCM01571.1 - 0.16 12.3 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3851) Pkinase PF00069.25 CCM01572.1 - 2.7e-65 220.4 0.1 1.4e-43 149.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01572.1 - 3.4e-28 98.7 0.1 1.5e-21 76.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 CCM01572.1 - 5.4e-07 28.9 0.1 9.5e-07 28.1 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CCM01572.1 - 8.9e-05 21.9 0.2 0.00068 19.0 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM01572.1 - 0.00015 21.8 2.1 0.03 14.2 0.2 2.7 1 1 2 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CCM01572.1 - 0.0076 15.6 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 CCM01572.1 - 0.013 16.2 0.1 0.032 15.0 0.1 1.7 1 0 0 1 1 1 0 Protein kinase C terminal domain Seadorna_VP7 PF07387.11 CCM01572.1 - 0.042 12.9 0.0 0.066 12.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 CCM01572.1 - 0.063 12.9 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 CCM01572.1 - 0.08 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 CCM01572.1 - 0.082 11.7 0.5 0.2 10.4 0.2 1.6 1 1 0 2 2 2 0 Fungal protein kinase BCDHK_Adom3 PF10436.9 CCM01573.1 - 1.6e-36 125.6 0.0 2.3e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Med20 PF08612.11 CCM01573.1 - 1.4e-08 34.4 0.0 1.7e-07 30.8 0.0 2.1 1 1 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex HATPase_c PF02518.26 CCM01573.1 - 1e-07 32.4 0.0 1.3e-05 25.7 0.0 2.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCM01573.1 - 0.18 11.6 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ORC4_C PF14629.6 CCM01574.1 - 8.6e-38 129.9 0.0 1.5e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 CCM01574.1 - 6.4e-17 62.5 0.1 1.4e-16 61.4 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CCM01574.1 - 0.00053 19.6 0.0 0.00098 18.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 CCM01574.1 - 0.0092 16.3 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CCM01574.1 - 0.0099 16.3 0.0 0.13 12.7 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CCM01574.1 - 0.024 14.3 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CCM01574.1 - 0.041 13.6 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCM01574.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM01574.1 - 0.088 12.7 0.1 0.57 10.1 0.1 2.2 1 1 0 1 1 1 0 NACHT domain RNA12 PF10443.9 CCM01574.1 - 0.18 10.5 0.0 0.35 9.6 0.0 1.3 1 0 0 1 1 1 0 RNA12 protein DUF3759 PF12585.8 CCM01575.1 - 1.3e-40 137.3 5.3 1.7e-40 136.9 5.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) DUF2939 PF11159.8 CCM01575.1 - 0.029 14.8 0.1 0.05 14.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2939) DUF3336 PF11815.8 CCM01576.1 - 7.9e-27 93.6 5.3 7.1e-16 58.2 1.1 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF3336) Patatin PF01734.22 CCM01576.1 - 6.7e-18 65.6 0.1 1.6e-17 64.4 0.1 1.7 1 0 0 1 1 1 1 Patatin-like phospholipase Malic_M PF03949.15 CCM01578.1 - 2.8e-87 292.2 0.0 4.1e-87 291.7 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CCM01578.1 - 5.6e-59 199.0 0.0 8.2e-59 198.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain MukF_C PF17193.4 CCM01578.1 - 0.17 12.0 0.0 14 5.7 0.0 2.4 2 0 0 2 2 2 0 MukF C-terminal domain PUB PF09409.10 CCM01579.1 - 1.6e-11 43.9 0.0 2.9e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 PUB domain ANAPC_CDC26 PF10471.9 CCM01579.1 - 0.011 16.5 1.4 0.011 16.5 1.4 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 PCI PF01399.27 CCM01582.1 - 1.9e-13 50.9 0.1 4.4e-12 46.4 0.0 2.9 3 0 0 3 3 3 1 PCI domain TAFH PF07531.14 CCM01582.1 - 0.061 13.4 0.1 1.8 8.7 0.0 2.9 3 0 0 3 3 3 0 NHR1 homology to TAF RPN7 PF10602.9 CCM01582.1 - 0.07 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Pkinase PF00069.25 CCM01583.1 - 3.7e-76 256.0 0.0 5e-76 255.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01583.1 - 4.6e-37 127.7 0.0 7.1e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM01583.1 - 2.3e-07 30.4 0.0 4.3e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CCM01583.1 - 0.0022 17.0 0.0 0.064 12.2 0.0 2.2 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 CCM01583.1 - 0.0043 15.9 1.4 0.011 14.5 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 CCM01583.1 - 0.08 12.3 0.1 0.22 10.9 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 CCM01584.1 - 1.9e-08 34.8 0.3 0.24 12.4 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Asp PF00026.23 CCM01585.1 - 1.1e-112 376.6 0.1 1.3e-112 376.4 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM01585.1 - 3.6e-15 56.6 0.7 1e-08 35.6 0.2 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CCM01585.1 - 2.4e-05 24.2 0.0 0.00057 19.7 0.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 CCM01585.1 - 0.00041 20.9 0.0 0.2 12.3 0.0 2.7 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 CCM01585.1 - 0.0018 18.8 0.0 0.86 10.2 0.0 2.7 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Bromodomain PF00439.25 CCM01586.1 - 1.3e-20 73.2 0.1 2.7e-20 72.2 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Trypan_PARP PF05887.11 CCM01586.1 - 0.0025 17.8 87.6 0.006 16.6 36.8 7.2 2 2 5 7 7 7 2 Procyclic acidic repetitive protein (PARP) PapJ PF14855.6 CCM01586.1 - 0.13 12.0 0.3 0.25 11.0 0.3 1.4 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone PA26 PF04636.13 CCM01586.1 - 4.7 6.0 19.8 11 4.8 19.8 1.7 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FAT PF02259.23 CCM01587.1 - 3.2e-69 233.8 5.7 5.6e-69 233.0 5.7 1.4 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 CCM01587.1 - 1.5e-27 97.0 0.3 3.1e-27 96.0 0.3 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 CCM01587.1 - 0.00027 20.7 0.0 0.00091 19.0 0.0 2.0 1 0 0 1 1 1 1 FATC domain GGDEF_2 PF17853.1 CCM01587.1 - 0.034 14.4 0.7 0.12 12.6 0.1 2.3 2 0 0 2 2 2 0 GGDEF-like domain TPR_8 PF13181.6 CCM01587.1 - 0.18 12.1 0.3 2.3 8.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat WH2 PF02205.20 CCM01589.1 - 1.3e-07 31.2 4.1 4.1e-07 29.6 1.1 2.5 2 0 0 2 2 2 1 WH2 motif Thioredoxin PF00085.20 CCM01590.1 - 9.4e-52 173.3 2.0 6.7e-25 87.1 0.0 3.4 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CCM01590.1 - 3e-31 108.8 0.4 3.1e-28 98.9 0.1 3.2 2 1 1 3 3 3 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CCM01590.1 - 4.5e-07 30.0 0.1 0.0016 18.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CCM01590.1 - 1.9e-06 28.1 0.4 0.1 12.9 0.0 3.4 4 0 0 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 CCM01590.1 - 2e-05 24.5 0.3 0.037 14.0 0.1 2.7 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_2 PF13098.6 CCM01590.1 - 0.0001 22.7 0.9 0.22 12.0 0.1 3.1 3 1 0 3 3 3 2 Thioredoxin-like domain Redoxin PF08534.10 CCM01590.1 - 0.00048 19.8 0.1 0.78 9.4 0.0 2.4 2 0 0 2 2 2 2 Redoxin OST3_OST6 PF04756.13 CCM01590.1 - 0.0075 15.7 0.5 2 7.7 0.0 2.9 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_4 PF13462.6 CCM01590.1 - 0.18 12.0 0.5 15 5.7 0.1 2.5 2 0 0 2 2 2 0 Thioredoxin TCTP PF00838.17 CCM01591.1 - 3.8e-67 225.8 1.5 4.2e-67 225.6 1.5 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein UTP15_C PF09384.10 CCM01592.1 - 7.3e-48 162.0 0.0 1.2e-47 161.3 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 CCM01592.1 - 9.9e-23 80.0 5.8 0.00073 20.3 0.2 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM01592.1 - 2.5e-08 34.1 0.0 0.072 13.4 0.0 4.9 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CCM01592.1 - 8.2e-05 21.3 0.4 0.0012 17.5 0.1 2.5 2 1 1 3 3 3 1 Cytochrome D1 heme domain Nup160 PF11715.8 CCM01592.1 - 0.0015 17.3 0.2 0.033 12.8 0.2 2.2 2 0 0 2 2 2 1 Nucleoporin Nup120/160 eIF2A PF08662.11 CCM01592.1 - 0.056 13.3 0.0 7.5 6.4 0.0 2.9 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A CTNNBL PF08216.11 CCM01593.1 - 7.3e-35 119.3 0.0 2.1e-34 117.8 0.0 1.9 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear DUF3868 PF12984.7 CCM01593.1 - 0.028 14.2 0.0 0.068 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3868) Arm PF00514.23 CCM01593.1 - 0.099 12.7 0.1 0.38 10.9 0.1 2.0 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat FAD_binding_3 PF01494.19 CCM01594.1 - 2.5e-24 86.2 1.2 1.2e-09 37.9 0.0 3.2 3 0 0 3 3 3 3 FAD binding domain Lycopene_cycl PF05834.12 CCM01594.1 - 3.5e-09 36.2 2.6 2e-08 33.7 0.4 2.8 3 1 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCM01594.1 - 5.4e-06 25.8 0.0 8.7e-05 21.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CCM01594.1 - 1e-05 24.6 0.2 0.0056 15.6 0.1 3.0 3 0 0 3 3 3 2 Tryptophan halogenase Thi4 PF01946.17 CCM01594.1 - 8.3e-05 21.9 0.1 0.00021 20.6 0.1 1.7 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 CCM01594.1 - 0.00044 20.3 0.1 0.0015 18.5 0.1 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding SE PF08491.10 CCM01594.1 - 0.00055 19.1 0.0 0.00091 18.4 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase DAO PF01266.24 CCM01594.1 - 0.00066 19.4 2.3 0.0013 18.4 1.8 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCM01594.1 - 0.0013 18.9 0.3 0.0037 17.5 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCM01594.1 - 0.0054 17.3 0.1 0.031 14.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM01594.1 - 0.036 12.8 0.3 0.064 11.9 0.3 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 CCM01594.1 - 0.039 13.2 0.0 0.091 12.0 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RRM_1 PF00076.22 CCM01595.1 - 1.6e-14 53.5 0.0 2.3e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L5e PF17144.4 CCM01596.1 - 2.6e-82 274.7 0.1 4.9e-82 273.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CCM01596.1 - 2.5e-34 118.1 1.7 2.5e-34 118.1 1.7 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region MtrA PF04208.14 CCM01596.1 - 0.14 11.7 0.0 0.5 10.0 0.0 1.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit A K_oxygenase PF13434.6 CCM01596.1 - 0.17 11.0 1.0 0.21 10.7 0.2 1.4 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Med17 PF10156.9 CCM01597.1 - 3.4e-38 131.5 0.0 4e-38 131.3 0.0 1.0 1 0 0 1 1 1 1 Subunit 17 of Mediator complex DUF3759 PF12585.8 CCM01597.1 - 0.081 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3759) Fungal_trans PF04082.18 CCM01598.1 - 5.4e-16 58.4 0.1 1.3e-15 57.2 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Paired_CXXCH_1 PF09699.10 CCM01598.1 - 6 6.7 5.3 0.48 10.2 0.3 1.8 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Exo_endo_phos PF03372.23 CCM01599.1 - 5.7e-08 32.6 0.1 1.1e-07 31.6 0.1 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GPI-anchored PF10342.9 CCM01600.1 - 0.00021 22.0 2.7 0.0028 18.4 0.3 3.3 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Snf7 PF03357.21 CCM01601.1 - 2.4e-29 102.1 21.1 2.4e-29 102.1 21.1 1.9 1 1 1 2 2 2 1 Snf7 Nuc_deoxyri_tr2 PF15891.5 CCM01601.1 - 0.14 12.5 0.7 4.5 7.6 0.0 2.6 2 1 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like PCNA_C PF02747.15 CCM01601.1 - 0.2 11.9 1.5 0.45 10.7 0.3 2.1 2 1 0 2 2 2 0 Proliferating cell nuclear antigen, C-terminal domain LUC7 PF03194.15 CCM01601.1 - 4.9 6.7 15.6 0.037 13.7 5.6 2.0 1 1 1 2 2 2 0 LUC7 N_terminus Iso_dh PF00180.20 CCM01602.1 - 1.7e-99 333.3 0.0 2e-99 333.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase RNB PF00773.19 CCM01603.1 - 1.1e-101 340.4 0.1 2.1e-101 339.5 0.1 1.5 1 0 0 1 1 1 1 RNB domain Dis3l2_C_term PF17877.1 CCM01603.1 - 1e-25 89.9 0.2 2.6e-25 88.5 0.2 1.8 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal OB_Dis3 PF17849.1 CCM01603.1 - 3.3e-25 87.9 0.0 8.4e-25 86.6 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 CCM01603.1 - 0.00017 21.7 0.0 0.053 13.7 0.0 2.7 2 0 0 2 2 2 2 Cold shock domain Rrp44_S1 PF17215.3 CCM01603.1 - 0.00075 19.4 0.0 0.0023 17.9 0.0 1.8 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 CCM01603.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 Rrp44-like cold shock domain Rpr2 PF04032.16 CCM01604.1 - 0.0075 16.5 0.1 0.017 15.4 0.1 1.6 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-Sec23_Sec24 PF04810.15 CCM01604.1 - 0.33 11.1 1.5 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger BTB_2 PF02214.22 CCM01605.1 - 0.2 12.0 0.2 2.6 8.4 0.0 2.7 2 1 0 2 2 2 0 BTB/POZ domain DnaJ PF00226.31 CCM01606.1 - 7.5e-18 64.4 0.0 1.2e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Toprim_2 PF13155.6 CCM01606.1 - 0.04 14.4 0.0 0.079 13.4 0.0 1.5 1 0 0 1 1 1 0 Toprim-like OAD_gamma PF04277.13 CCM01606.1 - 0.06 13.9 0.1 0.31 11.7 0.0 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Gln-synt_C PF00120.24 CCM01607.1 - 6.6e-17 61.5 0.0 2.2e-14 53.2 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CCM01607.1 - 6.9e-12 44.9 0.0 1.2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain VID27 PF08553.10 CCM01608.1 - 1.6e-173 576.8 0.3 2e-173 576.4 0.3 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 CCM01608.1 - 1.3e-55 187.9 0.2 1.3e-55 187.9 0.2 3.3 2 1 1 3 3 3 1 VID27 N-terminal region VID27_PH PF17747.1 CCM01608.1 - 2.7e-29 101.6 0.7 5.3e-29 100.7 0.1 1.9 2 0 0 2 2 2 1 VID27 PH-like domain NOA36 PF06524.12 CCM01608.1 - 2 7.7 10.0 4.3 6.6 10.0 1.5 1 0 0 1 1 1 0 NOA36 protein DUF3759 PF12585.8 CCM01609.1 - 0.00048 20.1 0.6 0.00098 19.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) zf-RRN7 PF11781.8 CCM01610.1 - 0.0039 16.8 0.0 0.0071 16.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Nop14 PF04147.12 CCM01610.1 - 0.02 13.1 0.8 0.029 12.6 0.8 1.1 1 0 0 1 1 1 0 Nop14-like family RIC1 PF07064.13 CCM01611.1 - 4e-93 311.4 0.0 5.3e-93 311.1 0.0 1.2 1 0 0 1 1 1 1 RIC1 Kelch_6 PF13964.6 CCM01611.1 - 0.018 15.3 0.0 0.14 12.5 0.0 2.4 2 0 0 2 2 2 0 Kelch motif ANAPC4_WD40 PF12894.7 CCM01611.1 - 0.034 14.4 0.0 0.32 11.3 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DIOX_N PF14226.6 CCM01612.1 - 1.6e-05 25.6 0.0 5.1e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM01612.1 - 0.0068 16.9 0.0 0.03 14.8 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_transf_28 PF03033.20 CCM01613.1 - 1.3e-29 103.0 0.0 2.6e-29 102.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 CCM01613.1 - 1.3e-22 79.8 0.2 1.1e-14 54.3 0.0 3.6 3 1 0 3 3 3 3 GRAM domain PH PF00169.29 CCM01613.1 - 1.2e-11 45.1 0.1 5.1e-10 39.8 0.1 2.8 2 0 0 2 2 2 1 PH domain UDPGT PF00201.18 CCM01613.1 - 1.2e-05 24.3 0.0 2.6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_11 PF15413.6 CCM01613.1 - 0.00023 21.6 0.9 0.018 15.5 0.9 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 CCM01613.1 - 0.0013 19.0 0.0 0.004 17.4 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 CCM01613.1 - 0.021 15.1 0.1 0.046 14.0 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain SUR7 PF06687.12 CCM01614.1 - 2.5e-13 50.1 5.0 3.4e-13 49.7 5.0 1.2 1 0 0 1 1 1 1 SUR7/PalI family Polysacc_deac_1 PF01522.21 CCM01615.1 - 1.1e-28 99.6 0.0 3.2e-28 98.1 0.0 1.8 1 0 0 1 1 1 1 Polysaccharide deacetylase nec1 PF10379.9 CCM01615.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 Virulence protein nec1 Polysacc_deac_1 PF01522.21 CCM01616.1 - 4e-06 26.7 0.0 7e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase NUC205 PF08168.11 CCM01617.1 - 0.16 11.5 0.1 0.28 10.7 0.1 1.4 1 0 0 1 1 1 0 NUC205 domain NAP PF00956.18 CCM01618.1 - 6.8e-28 97.6 4.1 8.1e-26 90.8 0.7 3.2 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Syja_N PF02383.18 CCM01619.1 - 2.3e-87 293.3 0.0 2.9e-87 293.0 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain LRR_9 PF14580.6 CCM01620.1 - 2.5e-57 193.2 0.6 7.5e-55 185.1 0.2 2.4 2 1 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 CCM01620.1 - 4.7e-11 42.7 20.3 1.7e-06 28.3 6.1 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCM01620.1 - 2.5e-07 30.3 8.9 7.3e-07 28.9 8.9 1.9 1 0 0 1 1 1 1 Leucine rich repeat LRR_6 PF13516.6 CCM01620.1 - 5.2 7.4 7.2 1.5 9.0 0.7 3.2 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 CCM01620.1 - 5.8 7.9 7.8 56 4.9 0.2 4.0 3 1 0 3 3 3 0 Leucine Rich Repeat DUF4149 PF13664.6 CCM01621.1 - 1.4e-24 86.3 4.9 1.4e-24 86.3 4.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) OPT PF03169.15 CCM01622.1 - 1.3e-172 575.7 46.1 1.5e-172 575.5 46.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MitMem_reg PF13012.6 CCM01623.1 - 2.6e-25 89.0 0.1 3.8e-25 88.5 0.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CCM01623.1 - 2.1e-12 47.0 0.0 3.6e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MCM PF00493.23 CCM01624.1 - 6.4e-103 342.7 0.0 1e-102 342.0 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCM01624.1 - 1.6e-33 115.2 0.0 3.7e-33 114.1 0.0 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCM01624.1 - 1.1e-28 99.5 1.0 2.3e-28 98.4 1.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCM01624.1 - 4.5e-15 56.1 0.5 1.9e-14 54.1 0.0 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CCM01624.1 - 7.3e-07 28.8 0.0 0.00021 20.7 0.0 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CCM01624.1 - 8.8e-05 22.5 0.0 0.00021 21.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CCM01624.1 - 0.00043 20.2 0.1 0.0023 17.8 0.0 2.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 CCM01624.1 - 0.0051 17.4 0.7 0.065 13.9 0.2 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI C-terminal AAA PF00004.29 CCM01624.1 - 0.066 13.6 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-C2H2 PF00096.26 CCM01625.1 - 7.3e-09 35.6 19.9 3.7e-06 27.1 0.3 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM01625.1 - 8.5e-07 29.3 13.9 0.0012 19.5 0.2 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf_ZIC PF18366.1 CCM01625.1 - 0.006 16.7 2.8 1 9.5 0.7 2.4 2 0 0 2 2 2 2 Zic proteins zinc finger domain zf-C2H2_jaz PF12171.8 CCM01625.1 - 0.015 15.6 2.1 0.34 11.3 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 CCM01625.1 - 0.035 14.5 0.7 0.035 14.5 0.7 3.5 4 0 0 4 4 4 0 Zinc-finger double domain ADK_lid PF05191.14 CCM01625.1 - 1.2 9.2 4.7 1.8 8.6 0.7 3.0 2 1 0 2 2 2 0 Adenylate kinase, active site lid Ribosomal_L37ae PF01780.19 CCM01625.1 - 1.4 9.0 3.9 12 6.1 0.1 2.6 2 1 1 3 3 3 0 Ribosomal L37ae protein family Catalase PF00199.19 CCM01626.1 - 2.4e-172 573.3 0.5 3.2e-172 572.9 0.5 1.2 1 0 0 1 1 1 1 Catalase Med6 PF04934.14 CCM01626.1 - 3.4e-28 98.1 0.1 7.4e-28 97.0 0.1 1.5 1 0 0 1 1 1 1 MED6 mediator sub complex component Catalase-rel PF06628.12 CCM01626.1 - 1.6e-17 63.5 0.1 4e-17 62.2 0.0 1.8 2 0 0 2 2 2 1 Catalase-related immune-responsive Catalase_C PF18011.1 CCM01626.1 - 1.5e-14 53.9 0.1 2.9e-14 53.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 CCM01626.1 - 9e-09 35.3 0.0 1.5e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Clat_adaptor_s PF01217.20 CCM01627.1 - 1.4e-40 138.5 0.1 4.5e-40 136.9 0.1 1.8 1 1 0 1 1 1 1 Clathrin adaptor complex small chain SelB-wing_2 PF09106.11 CCM01628.1 - 0.075 13.3 0.6 14 5.9 0.0 2.4 2 0 0 2 2 2 0 Elongation factor SelB, winged helix Glyco_hydro_18 PF00704.28 CCM01629.1 - 2.8e-23 83.1 4.7 5.6e-23 82.1 4.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_5_12 PF02839.14 CCM01629.1 - 1.6 9.5 8.8 5.3 7.8 3.3 3.3 2 0 0 2 2 2 0 Carbohydrate binding domain Pkinase PF00069.25 CCM01630.1 - 3.7e-65 219.9 0.2 4.5e-65 219.6 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01630.1 - 9.6e-20 70.9 0.0 1.4e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM01630.1 - 1.2e-06 28.6 0.0 3.5e-05 23.9 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM01630.1 - 0.004 16.0 0.0 0.0064 15.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCM01630.1 - 0.024 14.0 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CCM01630.1 - 0.042 13.4 0.1 0.083 12.5 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase SET PF00856.28 CCM01631.1 - 0.00014 22.3 0.0 0.0017 18.8 0.0 2.1 1 1 0 1 1 1 1 SET domain DnaJ_C PF01556.18 CCM01632.1 - 2.1e-36 125.2 0.0 2.8e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCM01632.1 - 3e-23 81.7 3.7 5.2e-23 80.9 3.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCM01632.1 - 4.4e-09 36.6 20.5 4.4e-09 36.6 20.5 1.8 2 0 0 2 2 2 1 DnaJ central domain Anti-TRAP PF15777.5 CCM01632.1 - 3.9 7.5 16.8 0.52 10.3 1.8 2.8 2 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCM01632.1 - 9 6.4 10.3 2.7 8.1 1.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA MFS_1 PF07690.16 CCM01633.1 - 1.2e-33 116.6 66.1 4.3e-33 114.7 49.6 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM01633.1 - 9.4e-09 34.6 10.4 9.4e-09 34.6 10.4 3.1 4 0 0 4 4 4 1 Sugar (and other) transporter CclA_1 PF16942.5 CCM01633.1 - 0.0037 17.5 2.6 0.014 15.7 2.6 2.0 1 0 0 1 1 1 1 Putative cyclic bacteriocin Phage_T7_tail PF03906.14 CCM01633.1 - 0.017 14.8 0.1 0.029 14.1 0.1 1.3 1 0 0 1 1 1 0 Phage T7 tail fibre protein Choline_kinase PF01633.20 CCM01634.1 - 1e-52 178.8 0.0 1.4e-52 178.3 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 CCM01634.1 - 6.1e-11 42.7 0.2 9.6e-11 42.1 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family BLM10_mid PF16507.5 CCM01635.1 - 1.1e-116 390.6 0.0 6.6e-111 371.5 0.0 2.6 3 0 0 3 3 3 2 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 CCM01635.1 - 2.3e-29 101.1 0.0 7.2e-29 99.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) zf-CCCH PF00642.24 CCM01635.1 - 3.7e-17 61.7 13.3 2e-09 37.1 2.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCM01635.1 - 1.3e-06 28.2 12.7 0.00017 21.5 2.8 2.5 2 0 0 2 2 2 2 Zinc finger domain HEAT PF02985.22 CCM01635.1 - 5.4e-06 26.2 1.5 0.096 13.0 0.1 5.4 5 0 0 5 5 5 1 HEAT repeat zf-CCCH_4 PF18044.1 CCM01635.1 - 0.00068 19.4 10.2 0.11 12.4 3.6 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger HEAT_2 PF13646.6 CCM01635.1 - 0.0079 16.6 0.0 0.059 13.8 0.0 2.6 2 0 0 2 2 2 1 HEAT repeats zf-CCCH_2 PF14608.6 CCM01635.1 - 3.7 8.2 8.0 4.9 7.8 0.2 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger BLM10_mid PF16507.5 CCM01636.1 - 6.6e-31 107.6 0.1 9.6e-31 107.0 0.1 1.2 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 CCM01636.1 - 0.00075 19.7 0.0 0.0015 18.8 0.0 1.4 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal TIM21 PF08294.11 CCM01637.1 - 1.6e-24 86.4 0.0 1.3e-19 70.5 0.0 2.2 2 0 0 2 2 2 2 TIM21 ATP-synt_F PF01990.17 CCM01638.1 - 1.6e-31 108.5 0.1 1.8e-31 108.3 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.6 CCM01638.1 - 0.045 13.0 0.0 0.045 13.0 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase DUF2759 PF10958.8 CCM01638.1 - 0.13 12.0 0.1 14 5.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2759) SGT1 PF07093.11 CCM01639.1 - 1.9e-98 330.4 6.5 7e-97 325.3 0.4 3.1 1 1 0 2 2 2 2 SGT1 protein BLM10_mid PF16507.5 CCM01642.1 - 5.3e-132 441.1 0.0 3.5e-131 438.4 0.0 2.1 1 1 0 1 1 1 1 Proteasome-substrate-size regulator, mid region Translin PF01997.16 CCM01642.1 - 1e-68 231.3 0.1 2.4e-68 230.2 0.1 1.7 1 0 0 1 1 1 1 Translin family DUF3437 PF11919.8 CCM01642.1 - 1.6e-08 34.3 1.1 1.1e-07 31.7 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HEAT PF02985.22 CCM01642.1 - 1e-05 25.4 9.5 0.04 14.2 0.1 6.1 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 CCM01642.1 - 0.0005 20.4 3.1 0.63 10.5 0.0 5.7 6 0 0 6 6 6 1 HEAT repeats HD_assoc PF13286.6 CCM01642.1 - 0.0028 18.2 0.0 0.022 15.3 0.0 2.5 3 0 0 3 3 3 1 Phosphohydrolase-associated domain SesA PF17107.5 CCM01642.1 - 0.062 13.5 0.0 1.4 9.2 0.0 2.9 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases BLM10_mid PF16507.5 CCM01643.1 - 0.00012 20.9 0.2 0.00023 20.0 0.1 1.5 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 CCM01643.1 - 0.00082 19.6 0.1 0.0022 18.2 0.1 1.7 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal CHASE3 PF05227.13 CCM01644.1 - 0.039 13.9 0.3 3.2 7.7 0.1 2.2 2 0 0 2 2 2 0 CHASE3 domain ATP-grasp_2 PF08442.10 CCM01646.1 - 3.4e-72 242.3 0.9 9e-72 240.9 0.4 1.8 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 CCM01646.1 - 2.4e-26 92.4 0.1 5.2e-26 91.3 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CCM01646.1 - 1.9e-10 40.6 0.2 6.9e-10 38.8 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 CCM01646.1 - 0.00081 19.2 0.3 0.016 15.0 0.0 2.5 2 1 1 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DinB_2 PF12867.7 CCM01647.1 - 4.1e-06 27.3 2.2 5.3e-06 27.0 2.2 1.2 1 0 0 1 1 1 1 DinB superfamily DinB PF05163.12 CCM01647.1 - 0.00088 19.2 1.1 0.0016 18.4 0.4 1.6 1 1 1 2 2 2 1 DinB family Orthopox_35kD PF02250.15 CCM01647.1 - 0.081 12.6 0.2 0.11 12.2 0.2 1.1 1 0 0 1 1 1 0 35kD major secreted virus protein Hist_deacetyl PF00850.19 CCM01648.1 - 7.1e-88 295.0 0.0 9.1e-88 294.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain XPA_C PF05181.12 CCM01649.1 - 2.3e-16 59.5 1.5 4.6e-16 58.5 1.5 1.5 1 0 0 1 1 1 1 XPA protein C-terminus 4HBT_3 PF13622.6 CCM01650.1 - 3.5e-58 197.8 0.0 4.1e-58 197.6 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CCM01650.1 - 5.1e-25 87.9 0.0 5.8e-20 71.5 0.0 3.0 2 1 0 2 2 2 2 Acyl-CoA thioesterase Ribosomal_S27e PF01667.17 CCM01651.1 - 4.9e-28 96.6 1.7 7.7e-28 96.0 1.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 CCM01651.1 - 0.27 10.8 1.6 0.52 9.9 1.6 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding BTG PF07742.12 CCM01652.1 - 4.4e-17 62.0 0.0 7.7e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 BTG family CCDC158 PF15921.5 CCM01652.1 - 1.9 6.2 5.9 2.4 5.9 5.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 BATS PF06968.13 CCM01654.1 - 3.9e-22 78.2 0.1 5.1e-21 74.6 0.0 2.2 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CCM01654.1 - 1.8e-16 61.0 0.0 3.1e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily EF1G PF00647.19 CCM01656.1 - 1e-43 147.7 0.1 2e-43 146.8 0.1 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 CCM01656.1 - 1.2e-11 44.7 0.4 2.9e-11 43.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCM01656.1 - 3.4e-11 43.3 0.0 3.4e-11 43.3 0.0 2.3 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCM01656.1 - 1.5e-09 38.1 0.2 4e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCM01656.1 - 5.1e-09 36.2 0.0 1.4e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM01656.1 - 1.4e-08 34.7 0.0 4.1e-08 33.1 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCM01656.1 - 2.8e-05 24.3 0.0 6.4e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_5 PF18485.1 CCM01656.1 - 0.046 14.1 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Phos_pyr_kin PF08543.12 CCM01656.1 - 0.072 12.5 0.0 0.21 10.9 0.0 1.7 2 0 0 2 2 2 0 Phosphomethylpyrimidine kinase Tom37 PF10568.9 CCM01656.1 - 0.082 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Sugar_tr PF00083.24 CCM01657.1 - 1.8e-90 304.0 31.1 1.6e-65 221.7 12.4 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCM01657.1 - 1.7e-11 43.7 41.8 3.5e-06 26.2 13.8 3.0 3 0 0 3 3 3 3 Major Facilitator Superfamily Glyco_hydro_79C PF16862.5 CCM01660.1 - 1.3e-20 74.2 0.3 3.3e-20 72.9 0.3 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain Glyco_hydro_12 PF01670.16 CCM01661.1 - 4.6e-36 124.8 11.0 5.5e-36 124.6 11.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Lycopene_cycl PF05834.12 CCM01661.1 - 0.093 11.8 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein PPV_E2_C PF00511.17 CCM01661.1 - 7 6.9 7.4 7.4 6.8 0.7 2.4 1 1 1 2 2 2 0 E2 (early) protein, C terminal Epimerase PF01370.21 CCM01662.1 - 3.2e-07 30.1 0.0 1.8e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM01662.1 - 1.4e-06 28.3 0.1 2.1e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCM01662.1 - 7.1e-06 26.3 0.0 1.4e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCM01662.1 - 3.7e-05 23.8 0.0 8.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 CCM01662.1 - 0.00027 20.2 0.1 0.0011 18.2 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein NmrA PF05368.13 CCM01662.1 - 0.00075 19.1 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 CCM01662.1 - 0.0011 19.4 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCM01662.1 - 0.029 15.0 0.0 0.071 13.7 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 CCM01662.1 - 0.046 12.7 0.0 0.27 10.2 0.0 2.2 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family zf-C2H2 PF00096.26 CCM01663.1 - 7.4e-07 29.3 0.4 0.014 15.8 0.1 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM01663.1 - 0.0054 17.5 0.6 0.67 10.9 0.0 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCM01663.1 - 0.26 11.1 2.8 2.3 8.0 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 CCM01663.1 - 0.29 11.2 2.1 3.3 7.8 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger MFS_1 PF07690.16 CCM01665.1 - 4.8e-43 147.4 40.2 4.8e-43 147.4 40.2 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 CCM01665.1 - 0.47 8.8 19.5 0.016 13.6 7.0 2.3 2 0 0 2 2 2 0 Transmembrane secretion effector zf-C2HC5 PF06221.13 CCM01666.1 - 9.9e-18 63.9 8.4 1.5e-17 63.3 8.4 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type zf-ribbon_3 PF13248.6 CCM01666.1 - 0.13 11.7 1.6 4.7 6.8 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 CCM01666.1 - 0.26 11.4 2.0 0.57 10.4 2.0 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DUF4407 PF14362.6 CCM01667.1 - 0.44 9.9 7.1 0.23 10.8 1.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 CCM01667.1 - 0.77 8.6 18.1 1.9 7.3 1.1 3.6 3 0 0 3 3 3 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 CCM01667.1 - 4.2 7.6 19.6 1.1 9.5 0.4 4.5 4 0 0 4 4 4 0 TATA element modulatory factor 1 TATA binding CBFB_NFYA PF02045.15 CCM01667.1 - 5.4 7.7 5.6 43 4.8 1.3 3.5 3 0 0 3 3 3 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Pkinase_fungal PF17667.1 CCM01669.1 - 1.2e-47 162.6 0.0 1.2e-27 96.8 0.0 2.3 1 1 1 2 2 2 2 Fungal protein kinase APH PF01636.23 CCM01669.1 - 4.4e-05 23.5 0.2 0.00011 22.2 0.2 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 CCM01669.1 - 0.0032 16.9 0.0 0.0055 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CCM01670.1 - 7.8e-48 163.2 0.0 9.3e-28 97.1 0.0 2.3 1 1 1 2 2 2 2 Fungal protein kinase APH PF01636.23 CCM01670.1 - 0.011 15.7 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 CCM01670.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain BTB PF00651.31 CCM01671.1 - 8e-18 64.7 0.0 8.6e-10 38.8 0.1 3.0 2 1 0 2 2 2 2 BTB/POZ domain FeoB_Cyto PF17910.1 CCM01671.1 - 0.1 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 FeoB cytosolic helical domain Helicase_C PF00271.31 CCM01673.1 - 3.8e-15 56.2 0.0 8e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Glyco_hydro_3_C PF01915.22 CCM01674.1 - 1.9e-53 181.4 0.1 3.3e-53 180.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCM01674.1 - 1.5e-36 126.4 0.0 2.5e-36 125.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCM01674.1 - 2.8e-18 65.8 0.0 5.9e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Ser_hydrolase PF06821.13 CCM01674.1 - 0.018 14.9 0.0 0.018 14.9 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Glyco_hydro_3_C PF01915.22 CCM01675.1 - 3.1e-54 184.0 0.0 4.9e-54 183.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCM01675.1 - 7.6e-40 137.2 0.0 1.3e-39 136.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCM01675.1 - 2.4e-18 66.0 0.0 6.3e-18 64.7 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain BTB PF00651.31 CCM01676.1 - 2.1e-12 47.3 0.0 8.5e-08 32.4 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain adh_short PF00106.25 CCM01677.1 - 1.2e-33 116.3 0.0 1.8e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01677.1 - 2.1e-20 73.3 0.0 3.7e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CCM01677.1 - 0.001 18.6 0.0 0.0018 17.8 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCM01677.1 - 0.003 17.5 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 KR domain zf-ZPR1 PF03367.13 CCM01677.1 - 0.046 13.6 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 ZPR1 zinc-finger domain SurA_N_2 PF13623.6 CCM01678.1 - 0.015 15.2 1.2 0.034 14.0 0.1 1.9 2 0 0 2 2 2 0 SurA N-terminal domain Evf PF18270.1 CCM01678.1 - 0.13 11.7 0.4 1.2 8.5 0.1 2.0 2 0 0 2 2 2 0 Virulence factor Evf adh_short PF00106.25 CCM01679.1 - 1.2e-33 116.2 0.0 1.7e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM01679.1 - 3.4e-21 75.9 0.0 5e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCM01679.1 - 0.00028 20.8 0.0 0.00041 20.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding SWIB PF02201.18 CCM01680.1 - 2.7e-22 78.4 0.0 1.1e-21 76.5 0.0 2.0 2 0 0 2 2 2 1 SWIB/MDM2 domain BAR PF03114.18 CCM01681.1 - 3e-37 128.6 6.4 4.6e-37 127.9 6.4 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 CCM01681.1 - 1e-14 53.8 0.0 2.5e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCM01681.1 - 4e-14 52.2 0.0 1e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCM01681.1 - 3.2e-09 36.3 0.0 9.8e-09 34.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain BAR_3 PF16746.5 CCM01681.1 - 6.1e-06 26.1 5.0 1.2e-05 25.2 5.0 1.4 1 0 0 1 1 1 1 BAR domain of APPL family Arfaptin PF06456.13 CCM01681.1 - 0.0017 18.0 1.8 0.004 16.8 1.8 1.7 1 0 0 1 1 1 1 Arfaptin-like domain DUF365 PF04033.12 CCM01681.1 - 0.14 12.5 0.1 0.44 10.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF365) FapA PF03961.13 CCM01681.1 - 0.46 9.0 2.1 0.69 8.4 2.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Glutaredoxin PF00462.24 CCM01682.1 - 0.19 11.9 0.0 0.41 10.9 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin Securin PF04856.13 CCM01682.1 - 0.41 10.6 3.9 0.68 9.9 3.7 1.5 1 1 0 1 1 1 0 Securin sister-chromatid separation inhibitor p450 PF00067.22 CCM01683.1 - 1.8e-88 297.4 0.0 2.8e-88 296.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 CCM01683.1 - 5.9e-21 75.2 0.0 2e-20 73.5 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 CCM01683.1 - 4.4e-19 68.9 0.0 7e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CCM01683.1 - 6.2e-09 36.5 0.0 1.2e-08 35.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 CCM01683.1 - 0.045 14.0 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Flavodoxin domain Flavodoxin_NdrI PF07972.11 CCM01683.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 NrdI Flavodoxin like MFS_1 PF07690.16 CCM01685.1 - 6e-18 64.9 59.7 1e-16 60.9 33.5 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 CCM01687.1 - 1.2e-72 244.4 0.0 1.6e-72 244.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01687.1 - 8.5e-30 103.9 0.1 5.7e-22 78.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCM01687.1 - 6.6e-07 28.9 0.8 0.36 10.1 0.0 3.1 2 1 1 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 CCM01687.1 - 0.00028 19.8 0.3 0.0016 17.3 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 CCM01687.1 - 0.028 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCM01687.1 - 0.074 12.0 0.0 1.1 8.1 0.0 2.5 3 0 0 3 3 3 0 Haspin like kinase domain MFS_1 PF07690.16 CCM01688.1 - 1.1e-23 83.7 38.4 6.1e-10 38.6 11.1 3.7 1 1 2 3 3 3 3 Major Facilitator Superfamily TRI12 PF06609.13 CCM01688.1 - 1e-06 27.5 5.4 1.4e-05 23.7 0.5 2.2 1 1 1 2 2 2 2 Fungal trichothecene efflux pump (TRI12) PUCC PF03209.15 CCM01688.1 - 0.0053 15.8 4.3 0.0078 15.3 0.3 2.5 2 0 0 2 2 2 1 PUCC protein TMIE PF16038.5 CCM01688.1 - 0.14 12.0 0.2 0.5 10.2 0.2 1.9 1 0 0 1 1 1 0 TMIE protein Phage_holin_5_2 PF16079.5 CCM01688.1 - 0.19 12.1 1.3 0.8 10.1 0.1 2.5 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Ribosomal_S14 PF00253.21 CCM01689.1 - 1.6e-22 79.0 0.5 2.3e-22 78.5 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF3425 PF11905.8 CCM01690.1 - 9e-15 54.7 0.2 3.7e-14 52.8 0.1 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CCM01690.1 - 3.2e-08 33.6 2.1 3.2e-08 33.6 2.1 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 CCM01690.1 - 0.008 16.2 6.4 0.01 15.9 2.0 2.5 2 0 0 2 2 2 1 Basic region leucine zipper DUF4187 PF13821.6 CCM01693.1 - 3.7e-22 77.8 2.2 8.2e-22 76.7 2.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 CCM01693.1 - 3.9e-05 23.5 1.1 0.00012 21.9 1.0 1.9 2 0 0 2 2 2 1 G-patch domain Methyltransf_20 PF12147.8 CCM01693.1 - 0.0079 15.4 0.1 0.013 14.7 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase G-patch_2 PF12656.7 CCM01693.1 - 1.5 8.9 4.7 0.31 11.1 0.4 2.2 2 1 0 2 2 2 0 G-patch domain RRM_1 PF00076.22 CCM01694.1 - 6.3e-15 54.8 0.0 2.6e-11 43.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 CCM01694.1 - 0.04 13.9 0.1 10 6.2 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain RRM_5 PF13893.6 CCM01694.1 - 0.053 13.1 0.0 2.5 7.7 0.0 2.8 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Totivirus_coat PF05518.11 CCM01694.1 - 0.11 10.5 11.0 0.13 10.3 11.0 1.1 1 0 0 1 1 1 0 Totivirus coat protein SRP-alpha_N PF04086.13 CCM01694.1 - 0.25 11.2 11.8 0.38 10.6 11.8 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RRM_1 PF00076.22 CCM01695.1 - 0.022 14.6 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_cc PF11790.8 CCM01696.1 - 1.2e-54 185.5 1.2 1.5e-54 185.1 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Draxin PF15550.6 CCM01696.1 - 0.73 9.6 4.8 1 9.2 4.8 1.1 1 0 0 1 1 1 0 Draxin NUDE_C PF04880.13 CCM01696.1 - 1.2 9.6 21.6 2.4 8.6 21.6 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Pex14_N PF04695.13 CCM01696.1 - 2 9.1 15.1 3.6 8.2 15.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Mcm10 PF09332.11 CCM01696.1 - 2.1 7.7 5.0 2.8 7.3 5.0 1.1 1 0 0 1 1 1 0 Mcm10 replication factor SOG2 PF10428.9 CCM01696.1 - 2.2 7.4 19.8 2.9 7.0 19.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 CCM01696.1 - 2.9 7.7 11.4 3.7 7.4 11.4 1.1 1 0 0 1 1 1 0 SPX domain MAP65_ASE1 PF03999.12 CCM01696.1 - 4.1 6.0 10.3 5.2 5.7 10.3 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) KAR9 PF08580.10 CCM01696.1 - 4.6 5.7 11.1 5.2 5.5 11.1 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Shisa PF13908.6 CCM01696.1 - 5.4 7.2 10.2 9.1 6.5 10.2 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Apt1 PF10351.9 CCM01696.1 - 7 5.4 10.9 23 3.7 0.1 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain Ribosomal_L11 PF00298.19 CCM01698.1 - 4.1e-28 97.7 0.3 7.1e-28 96.9 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 CCM01698.1 - 2.6e-26 91.2 0.1 5.3e-26 90.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Peptidase_M28 PF04389.17 CCM01699.1 - 5.8e-28 97.9 0.0 8.1e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CCM01699.1 - 4e-06 26.7 0.0 7.8e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 C2 PF00168.30 CCM01702.1 - 9.7e-14 51.5 0.0 6.9e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 C2 domain Glyco_hydro_125 PF06824.11 CCM01703.1 - 7.4e-142 473.1 2.8 8.2e-141 469.7 2.8 1.9 1 1 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) DUF1640 PF07798.11 CCM01705.1 - 5.5e-39 134.0 5.6 6.5e-39 133.8 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) ATP_bind_1 PF03029.17 CCM01706.1 - 2.1e-49 168.5 0.0 2.9e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein T2SSE PF00437.20 CCM01706.1 - 0.00023 20.3 0.0 0.00034 19.8 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ArsA_ATPase PF02374.15 CCM01706.1 - 0.0023 17.2 0.0 0.003 16.8 0.0 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_16 PF13191.6 CCM01706.1 - 0.0043 17.5 0.0 0.0094 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CCM01706.1 - 0.0047 16.6 0.0 0.0086 15.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCM01706.1 - 0.008 16.7 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCM01706.1 - 0.0093 15.5 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 CCM01706.1 - 0.0097 16.2 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 CCM01706.1 - 0.01 15.6 0.2 0.054 13.3 0.0 2.3 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_33 PF13671.6 CCM01706.1 - 0.018 15.2 1.7 0.04 14.1 0.0 2.2 2 0 0 2 2 1 0 AAA domain DUF463 PF04317.12 CCM01706.1 - 0.029 13.3 0.0 0.045 12.7 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 MMR_HSR1 PF01926.23 CCM01706.1 - 0.034 14.2 0.1 0.14 12.2 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase MeaB PF03308.16 CCM01706.1 - 0.034 13.1 0.0 0.057 12.4 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 CCM01706.1 - 0.039 14.3 0.0 0.09 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase APS_kinase PF01583.20 CCM01706.1 - 0.045 13.6 0.0 0.077 12.9 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase CbiA PF01656.23 CCM01706.1 - 0.046 13.8 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Sigma54_activat PF00158.26 CCM01706.1 - 0.052 13.2 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 CCM01706.1 - 0.053 13.2 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CCM01706.1 - 0.057 13.3 0.1 0.15 12.0 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase KTI12 PF08433.10 CCM01706.1 - 0.058 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 CCM01706.1 - 0.063 13.8 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 CCM01706.1 - 0.077 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_10 PF12846.7 CCM01706.1 - 0.083 11.8 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_14 PF13173.6 CCM01706.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CCM01706.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.14 CCM01706.1 - 0.14 11.4 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_24 PF13479.6 CCM01706.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CCM01706.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PRK PF00485.18 CCM01706.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 CCM01706.1 - 0.2 11.6 0.1 0.47 10.4 0.1 1.6 2 0 0 2 2 2 0 NTPase Septin PF00735.18 CCM01706.1 - 0.23 10.7 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Septin Dynamin_N PF00350.23 CCM01707.1 - 6.8e-14 52.3 0.1 6.8e-14 52.3 0.1 3.5 3 1 0 3 3 3 1 Dynamin family FtsK_SpoIIIE PF01580.18 CCM01707.1 - 0.00034 20.0 0.0 0.001 18.4 0.0 1.8 1 0 0 1 1 1 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 CCM01707.1 - 0.00071 19.6 3.8 0.28 11.3 3.8 3.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM01707.1 - 0.0029 17.5 0.1 0.0029 17.5 0.1 2.5 3 0 0 3 3 3 1 RsgA GTPase T2SSE PF00437.20 CCM01707.1 - 0.0047 16.0 0.1 0.0094 15.0 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AIG1 PF04548.16 CCM01707.1 - 0.0069 15.7 0.1 0.031 13.6 0.1 2.1 1 0 0 1 1 1 1 AIG1 family AAA_22 PF13401.6 CCM01707.1 - 0.019 15.2 0.0 0.098 12.9 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 CCM01707.1 - 0.036 14.5 0.1 0.63 10.4 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 CCM01707.1 - 0.047 14.2 0.2 0.047 14.2 0.2 2.6 2 2 0 2 2 1 0 ABC transporter Sec8_exocyst PF04048.14 CCM01707.1 - 0.057 13.3 7.9 3.4 7.6 0.2 3.9 4 0 0 4 4 4 0 Sec8 exocyst complex component specific domain DUF87 PF01935.17 CCM01707.1 - 0.099 12.7 0.1 0.099 12.7 0.1 4.2 3 1 1 4 4 4 0 Helicase HerA, central domain Mlh1_C PF16413.5 CCM01707.1 - 1.1 8.5 5.1 1.2 8.5 0.9 2.6 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus BUD22 PF09073.10 CCM01707.1 - 2.3 7.5 41.2 0.51 9.6 1.8 2.2 2 0 0 2 2 2 0 BUD22 Prefoldin PF02996.17 CCM01707.1 - 9.3 6.2 12.3 17 5.3 1.8 3.1 2 0 0 2 2 2 0 Prefoldin subunit MFS_1 PF07690.16 CCM01709.1 - 9.4e-33 113.6 20.3 1.2e-32 113.2 20.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TssO PF17561.2 CCM01709.1 - 0.022 14.8 0.0 10 6.2 0.0 2.5 2 0 0 2 2 2 0 Type VI secretion system, TssO Ldr_toxin PF13940.6 CCM01709.1 - 0.066 13.3 0.2 0.25 11.4 0.2 2.0 1 0 0 1 1 1 0 Toxin Ldr, type I toxin-antitoxin system Snf7 PF03357.21 CCM01710.1 - 1.2e-45 155.3 12.6 1.4e-45 155.0 12.6 1.0 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 CCM01710.1 - 0.0088 16.5 0.3 0.47 11.0 0.1 2.6 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 CCM01710.1 - 0.015 15.6 2.9 1.5 9.3 0.0 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Ca_bind_SSO6904 PF18249.1 CCM01710.1 - 0.025 14.9 0.1 0.046 14.1 0.1 1.6 1 0 0 1 1 1 0 Calcium binding protein SSO6904 Uso1_p115_C PF04871.13 CCM01710.1 - 0.038 14.4 15.4 0.075 13.4 10.6 2.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Prefoldin_2 PF01920.20 CCM01710.1 - 0.055 13.4 11.3 3.1 7.8 0.1 3.5 2 1 0 3 3 3 0 Prefoldin subunit APG6_N PF17675.1 CCM01710.1 - 0.28 11.7 15.3 1.8 9.1 1.4 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region Prefoldin PF02996.17 CCM01710.1 - 0.51 10.3 8.3 1.2 9.1 0.1 3.4 2 1 0 2 2 2 0 Prefoldin subunit RPW8 PF05659.11 CCM01710.1 - 0.55 9.9 6.3 0.42 10.3 3.2 2.2 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF2730 PF10805.8 CCM01710.1 - 0.58 10.3 5.6 0.49 10.5 0.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) DUF5344 PF17279.2 CCM01710.1 - 0.59 10.8 7.9 1.5 9.5 4.4 2.8 1 1 0 2 2 2 0 Family of unknown function (DUF5344) Macoilin PF09726.9 CCM01710.1 - 0.79 8.2 8.5 1.2 7.6 8.5 1.4 1 1 0 1 1 1 0 Macoilin family SlyX PF04102.12 CCM01710.1 - 1 10.0 8.4 5.8 7.6 0.0 3.8 2 1 0 2 2 2 0 SlyX FapA PF03961.13 CCM01710.1 - 1.2 7.7 8.8 0.42 9.2 1.7 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A zf-C4H2 PF10146.9 CCM01710.1 - 1.6 9.0 9.8 4.3 7.6 6.2 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein GPS2_interact PF15784.5 CCM01710.1 - 3.6 8.1 7.6 0.73 10.3 1.7 2.4 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain Aldedh PF00171.22 CCM01711.1 - 8e-148 492.8 0.1 9.8e-148 492.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCM01711.1 - 0.007 15.5 0.1 0.017 14.2 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) Abhydrolase_1 PF00561.20 CCM01712.1 - 2.8e-41 141.8 0.1 2e-40 139.1 0.0 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 CCM01712.1 - 0.00069 19.3 0.1 0.0012 18.6 0.1 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_4 PF08386.10 CCM01712.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_2 PF02230.16 CCM01712.1 - 0.23 11.2 0.2 0.81 9.4 0.1 1.8 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pex14_N PF04695.13 CCM01712.1 - 3.1 8.5 7.0 4.4 7.9 0.2 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Snf7 PF03357.21 CCM01714.1 - 7.3e-10 38.7 14.8 9.6e-10 38.3 14.8 1.1 1 0 0 1 1 1 1 Snf7 DMSP_lyase PF16867.5 CCM01714.1 - 0.015 15.0 0.0 0.036 13.7 0.0 1.7 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Ist1 PF03398.14 CCM01714.1 - 0.02 14.8 5.6 0.033 14.1 5.6 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway SAS4 PF15460.6 CCM01714.1 - 0.088 12.9 0.4 0.088 12.9 0.4 2.3 1 1 1 2 2 2 0 Something about silencing, SAS, complex subunit 4 T3SS_basalb_I PF17001.5 CCM01714.1 - 4.5 7.9 11.7 2.4 8.8 3.4 3.1 1 1 2 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI MUG113 PF13455.6 CCM01715.1 - 1.4e-13 51.3 0.0 6.1e-13 49.2 0.0 2.1 1 1 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 CCM01715.1 - 7.2e-09 36.1 0.1 5.2e-07 30.1 0.0 2.8 1 1 0 2 2 2 1 T5orf172 domain LON_substr_bdg PF02190.16 CCM01716.1 - 6.7e-16 58.8 0.0 9.1e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 CCM01717.1 - 0.00041 20.1 9.3 0.009 15.8 1.7 2.9 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCM01717.1 - 0.0028 17.8 9.1 0.03 14.5 1.9 2.6 2 0 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCM01717.1 - 0.0063 16.5 13.4 0.11 12.5 2.7 2.6 2 0 0 2 2 2 2 RING-type zinc-finger zf-RING_5 PF14634.6 CCM01717.1 - 0.36 10.8 12.1 3.9 7.5 4.0 3.0 2 1 1 3 3 3 0 zinc-RING finger domain zf-C3HC4 PF00097.25 CCM01717.1 - 0.46 10.4 12.1 0.33 10.8 1.6 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM01717.1 - 1 9.3 8.3 9.8 6.1 2.8 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SWIRM-assoc_2 PF16496.5 CCM01717.1 - 6.7 5.5 6.3 13 4.5 6.3 1.4 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Amidohydro_2 PF04909.14 CCM01718.1 - 4.8e-07 29.8 0.4 9.6e-07 28.9 0.4 1.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 CCM01718.1 - 0.00062 19.2 0.0 0.00082 18.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Kinesin PF00225.23 CCM01719.1 - 1.4e-106 356.2 0.0 2.7e-106 355.3 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCM01719.1 - 5.2e-24 84.9 0.0 1e-23 83.9 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Eapp_C PF10238.9 CCM01719.1 - 0.44 10.6 1.6 1.4 9.0 1.6 1.8 1 0 0 1 1 1 0 E2F-associated phosphoprotein YscO-like PF16789.5 CCM01719.1 - 1.1 9.2 12.3 0.19 11.7 7.6 2.1 1 1 1 2 2 2 0 YscO-like protein EMP24_GP25L PF01105.24 CCM01720.1 - 1e-52 178.7 0.1 1.2e-52 178.5 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Ran_BP1 PF00638.18 CCM01721.1 - 3.4e-50 169.4 0.6 5e-50 168.9 0.6 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 CCM01721.1 - 9.6e-05 22.3 0.6 0.00067 19.6 0.6 1.9 1 1 0 1 1 1 1 WH1 domain DUF1681 PF07933.14 CCM01721.1 - 0.00037 20.2 0.2 0.00044 20.0 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) AAA_2 PF07724.14 CCM01722.1 - 1.3e-38 132.8 0.0 2.2e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CCM01722.1 - 1.5e-14 54.5 0.0 3e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CCM01722.1 - 1.4e-09 37.8 0.0 2.7e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CCM01722.1 - 4.7e-05 23.4 0.0 0.00013 21.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCM01722.1 - 0.00013 22.2 0.1 0.0016 18.7 0.1 2.4 2 1 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 CCM01722.1 - 0.00016 21.2 0.0 0.0047 16.3 0.0 2.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CCM01722.1 - 0.0021 18.5 0.0 0.0046 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CCM01722.1 - 0.0033 17.2 0.2 0.054 13.2 0.0 2.5 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 CCM01722.1 - 0.0041 16.6 0.0 0.007 15.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 CCM01722.1 - 0.007 15.5 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein Sigma54_activat PF00158.26 CCM01722.1 - 0.0091 15.7 0.0 0.1 12.3 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 CCM01722.1 - 0.011 15.4 0.0 0.035 13.8 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.6 CCM01722.1 - 0.012 15.8 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 CCM01722.1 - 0.013 14.6 0.0 0.061 12.4 0.0 2.0 3 0 0 3 3 3 0 MCM P-loop domain RNA_helicase PF00910.22 CCM01722.1 - 0.018 15.4 0.0 0.13 12.6 0.0 2.4 2 1 0 2 2 2 0 RNA helicase Sigma54_activ_2 PF14532.6 CCM01722.1 - 0.023 14.8 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 CCM01722.1 - 0.032 14.0 0.0 0.049 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CCM01722.1 - 0.039 13.8 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CCM01722.1 - 0.04 14.4 0.0 0.072 13.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 CCM01722.1 - 0.045 13.2 0.0 0.079 12.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DEAD PF00270.29 CCM01722.1 - 0.046 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AIRS_C PF02769.22 CCM01722.1 - 0.047 13.8 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 AIR synthase related protein, C-terminal domain TsaE PF02367.17 CCM01722.1 - 0.051 13.6 0.0 0.085 12.9 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CCM01722.1 - 0.058 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM01722.1 - 0.073 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain FtsK_SpoIIIE PF01580.18 CCM01722.1 - 0.075 12.4 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.6 CCM01722.1 - 0.13 12.9 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCM01722.1 - 0.13 12.0 0.0 0.42 10.4 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Cactin_mid PF10312.9 CCM01723.1 - 6.7e-66 221.8 7.2 6.7e-66 221.8 7.2 2.6 3 1 0 3 3 3 1 Conserved mid region of cactin CactinC_cactus PF09732.9 CCM01723.1 - 3.9e-60 201.3 6.6 1e-59 199.9 6.6 1.8 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein tRNA_synthFbeta PF17759.1 CCM01724.1 - 8.8e-11 41.6 0.0 1e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2d PF01409.20 CCM01724.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) DUF2370 PF10176.9 CCM01725.1 - 5.2e-75 252.0 0.0 7.9e-75 251.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Peptidase_M48 PF01435.18 CCM01726.1 - 0.01 15.6 29.2 0.18 11.5 1.2 5.2 1 1 4 5 5 5 0 Peptidase family M48 DUF1081 PF06448.11 CCM01726.1 - 0.011 16.1 4.9 8.9 6.7 1.8 4.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1081) DUF4731 PF15875.5 CCM01726.1 - 1.6 8.9 32.4 27 5.0 0.6 7.8 1 1 7 9 9 9 0 Domain of unknown function (DUF4731) DUF3328 PF11807.8 CCM01727.1 - 2.1e-51 174.8 0.1 2.4e-51 174.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) SCAMP PF04144.13 CCM01727.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 SCAMP family DUF3328 PF11807.8 CCM01728.1 - 6.4e-63 212.5 0.4 7.9e-63 212.2 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Calreticulin PF00262.18 CCM01729.1 - 0.018 13.9 0.5 0.022 13.7 0.5 1.0 1 0 0 1 1 1 0 Calreticulin family Bclx_interact PF08945.10 CCM01729.1 - 0.1 12.4 7.6 0.71 9.7 1.0 2.3 1 1 1 2 2 2 0 Bcl-x interacting, BH3 domain PepSY_2 PF13670.6 CCM01730.1 - 0.0053 16.7 0.7 0.23 11.5 0.1 2.1 1 1 1 2 2 2 2 Peptidase propeptide and YPEB domain TFIIF_beta PF02270.15 CCM01730.1 - 0.095 12.8 1.3 3.3 7.9 0.1 2.6 1 1 1 2 2 2 0 TFIIF, beta subunit HTH domain DsrH PF04077.12 CCM01730.1 - 0.14 12.3 1.1 79 3.5 0.0 3.0 1 1 2 3 3 3 0 DsrH like protein IGPS PF00218.21 CCM01731.1 - 2.5e-89 298.8 0.0 6e-89 297.6 0.0 1.6 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 CCM01731.1 - 6.2e-46 156.6 0.0 1e-45 155.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I PRAI PF00697.22 CCM01731.1 - 2.3e-43 148.2 0.0 3.2e-34 118.4 0.0 3.2 2 1 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Peptidase_C26 PF07722.13 CCM01731.1 - 4.1e-07 30.0 0.1 1.4e-06 28.3 0.1 1.8 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 CCM01731.1 - 0.0074 16.1 0.9 3.3 7.5 0.0 3.9 5 0 0 5 5 5 1 Quinolinate phosphoribosyl transferase, C-terminal domain ThiG PF05690.14 CCM01731.1 - 0.058 12.7 0.0 3.5 6.9 0.0 2.4 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG NanE PF04131.14 CCM01731.1 - 0.062 12.5 0.1 0.41 9.8 0.0 2.2 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 CCM01731.1 - 0.089 12.2 0.1 0.67 9.4 0.0 2.4 3 0 0 3 3 3 0 Histidine biosynthesis protein DUF1751 PF08551.10 CCM01733.1 - 6.7e-05 23.4 0.3 0.00013 22.5 0.3 1.5 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 CCM01733.1 - 0.0003 20.8 8.9 0.00095 19.1 8.9 1.7 1 1 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 CCM01733.1 - 0.00042 20.3 7.2 0.00073 19.6 7.2 1.4 1 0 0 1 1 1 1 Rhomboid family CUE PF02845.16 CCM01733.1 - 0.002 17.8 0.0 0.0037 16.9 0.0 1.4 1 0 0 1 1 1 1 CUE domain KNOX1 PF03790.13 CCM01733.1 - 0.29 10.9 2.6 0.57 9.9 2.6 1.4 1 0 0 1 1 1 0 KNOX1 domain eIF-3_zeta PF05091.12 CCM01734.1 - 5.6e-209 695.4 0.0 6.6e-209 695.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RRM_1 PF00076.22 CCM01735.1 - 3.2e-17 62.1 0.0 5.9e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM01735.1 - 3.8e-07 30.1 0.0 7.7e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 CCM01735.1 - 0.035 13.7 0.0 0.068 12.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1314 PF07013.11 CCM01735.1 - 0.049 13.5 0.0 0.098 12.5 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1314) YihI PF04220.12 CCM01735.1 - 0.66 9.7 13.5 0.3 10.8 10.8 2.0 1 1 0 1 1 1 0 Der GTPase activator (YihI) Beta_helix PF13229.6 CCM01736.1 - 1.2e-09 38.3 29.1 1.5e-09 37.9 20.9 3.1 1 1 1 2 2 2 2 Right handed beta helix region Disaggr_assoc PF08480.10 CCM01736.1 - 0.00018 21.5 12.3 0.068 13.1 1.7 3.6 2 1 1 3 3 3 3 Disaggregatase related Phage_holin_2_4 PF16082.5 CCM01736.1 - 0.033 13.9 3.2 2.6 7.9 0.1 2.6 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like PAP_central PF04928.17 CCM01737.1 - 7.9e-114 378.8 0.0 1e-113 378.4 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 CCM01737.1 - 5.3e-56 188.9 0.0 8.9e-56 188.2 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 CCM01737.1 - 5.6e-12 45.8 0.0 1.5e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 CCM01737.1 - 0.03 14.1 0.1 0.059 13.1 0.1 1.4 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 CCM01737.1 - 0.058 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase GatB_N PF02934.15 CCM01738.1 - 1.9e-108 362.0 0.0 2.6e-108 361.6 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 CCM01738.1 - 3e-31 108.3 0.0 4.8e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 GatB domain RecC_C PF17946.1 CCM01738.1 - 0.092 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 RecC C-terminal domain Thioredoxin_4 PF13462.6 CCM01739.1 - 4.6e-11 43.2 0.0 1.2e-10 41.8 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 CCM01739.1 - 0.012 15.4 0.8 0.53 10.0 0.1 2.7 1 1 1 2 2 2 0 DSBA-like thioredoxin domain PCI PF01399.27 CCM01740.1 - 5.8e-13 49.3 0.0 1.3e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain VWA PF00092.28 CCM01741.1 - 2.9e-05 24.4 0.0 0.00015 22.1 0.0 2.1 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CCM01741.1 - 0.04 14.6 0.0 0.11 13.2 0.0 1.9 1 1 0 1 1 1 0 von Willebrand factor type A domain CobT_C PF11775.8 CCM01741.1 - 0.14 11.8 0.0 8.6 5.9 0.0 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT VWA domain GCP_N_terminal PF17681.1 CCM01742.1 - 6.1e-30 104.9 0.2 1.2e-29 104.0 0.0 1.5 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CCM01742.1 - 1.1e-27 97.3 2.9 1.1e-27 97.3 2.9 1.5 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Ribul_P_3_epim PF00834.19 CCM01742.1 - 0.057 12.8 0.0 1 8.7 0.0 2.3 2 0 0 2 2 2 0 Ribulose-phosphate 3 epimerase family Mgm101p PF06420.12 CCM01743.1 - 3.4e-87 290.3 0.0 4.5e-87 289.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Peptidase_S10 PF00450.22 CCM01745.1 - 4.3e-99 332.8 0.0 5.3e-99 332.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DASH_Spc19 PF08287.11 CCM01746.1 - 4.7e-29 101.3 5.7 3.6e-28 98.4 5.7 2.0 1 1 0 1 1 1 1 Spc19 TRAF_BIRC3_bd PF16673.5 CCM01746.1 - 0.017 14.9 4.0 0.067 13.0 1.5 2.5 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain MoCF_biosynth PF00994.24 CCM01747.1 - 6.8e-58 194.4 0.2 1.3e-28 99.5 0.1 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 CCM01747.1 - 1.8e-37 128.5 0.2 2.8e-37 127.9 0.2 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 CCM01747.1 - 1.6e-13 50.6 0.1 3.9e-13 49.4 0.1 1.7 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) GDPD PF03009.17 CCM01748.1 - 1.2e-30 107.1 0.2 2.8e-30 105.9 0.2 1.6 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 CCM01748.1 - 8.1e-06 26.1 1.1 2.4e-05 24.6 1.1 1.9 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family FlaC_arch PF05377.11 CCM01749.1 - 0.084 13.3 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Peptidase_S64 PF08192.11 CCM01749.1 - 3.9 5.9 4.9 1.9 6.9 0.4 2.0 2 0 0 2 2 2 0 Peptidase family S64 Acyltransferase PF01553.21 CCM01751.1 - 3.3e-35 120.6 0.0 4.7e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase KRBA1 PF15287.6 CCM01751.1 - 0.59 9.9 3.1 1.3 8.7 0.0 2.6 2 0 0 2 2 2 0 KRBA1 family repeat Amidohydro_1 PF01979.20 CCM01752.1 - 8.1e-29 101.0 1.4 2.3e-27 96.2 1.4 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCM01752.1 - 7.5e-17 61.9 0.0 1.3e-10 41.4 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family G10 PF01125.17 CCM01754.1 - 2.7e-50 169.9 1.0 4.1e-50 169.4 1.0 1.2 1 0 0 1 1 1 1 G10 protein Na_H_Exchanger PF00999.21 CCM01754.1 - 3.2e-48 164.4 49.7 4.6e-48 163.9 49.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TB2_DP1_HVA22 PF03134.19 CCM01755.1 - 1.5e-10 40.9 0.1 2.7e-10 40.0 0.1 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family BNIP2 PF12496.8 CCM01755.1 - 0.4 11.1 4.9 0.3 11.5 2.7 2.0 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 GMC_oxred_N PF00732.19 CCM01756.1 - 9.9e-55 186.0 0.0 1.3e-54 185.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM01756.1 - 2.5e-33 115.6 0.0 4.3e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCM01756.1 - 0.0013 17.9 0.1 0.0049 16.0 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCM01756.1 - 0.0014 18.9 0.1 0.0042 17.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCM01756.1 - 0.0019 17.5 0.1 0.0049 16.2 0.0 1.6 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 CCM01756.1 - 0.0023 17.1 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CCM01756.1 - 0.0023 17.6 0.0 0.0042 16.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM01756.1 - 0.009 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM01756.1 - 0.012 14.3 0.1 0.38 9.4 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein GMC_oxred_N PF00732.19 CCM01757.1 - 1.5e-44 152.6 0.0 2.2e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM01757.1 - 5.7e-29 101.5 0.0 1e-28 100.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CCM01757.1 - 0.001 18.7 0.0 0.0021 17.7 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCM01757.1 - 0.0018 18.5 0.3 0.004 17.3 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCM01757.1 - 0.0039 16.3 0.2 0.0056 15.8 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCM01757.1 - 0.0093 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCM01757.1 - 0.05 12.8 0.0 0.11 11.7 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM01757.1 - 0.071 12.3 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 CCM01757.1 - 0.084 11.6 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.14 CCM01757.1 - 0.13 11.5 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MWFE PF15879.5 CCM01758.1 - 2.1e-23 82.2 0.1 2.6e-23 81.9 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit LPD26 PF18842.1 CCM01758.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 26 SANT_DAMP1_like PF16282.5 CCM01759.1 - 2.9e-31 107.5 4.3 5.8e-31 106.5 4.3 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_6 PF13921.6 CCM01759.1 - 0.00021 21.4 0.0 0.00051 20.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CCM01759.1 - 0.00053 20.1 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Lip_prot_lig_C PF10437.9 CCM01759.1 - 0.11 12.5 0.1 0.49 10.4 0.0 2.0 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus DUF498 PF04430.14 CCM01760.1 - 8.5e-36 122.3 0.0 1e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) LigT_PEase PF02834.16 CCM01761.1 - 0.075 13.2 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 LigT like Phosphoesterase CX9C PF16860.5 CCM01762.1 - 3.3e-05 23.8 12.0 0.00076 19.4 6.2 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 CCM01762.1 - 0.00018 21.6 14.3 0.00032 20.8 6.9 2.4 2 0 0 2 2 2 2 CHCH domain PBP_GOBP PF01395.22 CCM01762.1 - 0.0056 16.8 1.0 0.01 16.0 1.0 1.4 1 0 0 1 1 1 1 PBP/GOBP family DB PF01682.19 CCM01762.1 - 0.18 12.1 7.3 2 8.7 0.3 2.1 1 1 1 2 2 2 0 DB module NDUF_B7 PF05676.13 CCM01762.1 - 5.2 6.9 11.1 1 9.1 5.0 2.1 1 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF202 PF02656.15 CCM01763.1 - 4.6e-15 55.8 2.1 4.6e-15 55.8 2.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) THOC7 PF05615.13 CCM01764.1 - 6e-32 110.7 4.4 6e-32 110.7 4.4 2.2 1 1 1 2 2 2 1 Tho complex subunit 7 Lactamase_B_2 PF12706.7 CCM01765.1 - 1.8e-08 34.1 0.1 0.004 16.7 0.0 3.2 2 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 CCM01765.1 - 3.4e-08 33.0 0.0 5.9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.27 CCM01765.1 - 1.2e-05 25.4 1.0 2.6e-05 24.3 0.1 2.0 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily PDEase_II PF02112.15 CCM01765.1 - 0.013 14.6 0.1 0.021 13.9 0.1 1.3 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II Myc_N PF01056.18 CCM01766.1 - 0.12 12.2 8.6 0.23 11.4 8.6 1.4 1 0 0 1 1 1 0 Myc amino-terminal region PPP4R2 PF09184.11 CCM01766.1 - 0.67 9.5 6.8 1 8.9 6.8 1.2 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 CCM01766.1 - 0.93 8.7 6.5 1.4 8.1 6.5 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 CCM01766.1 - 1.3 8.7 12.5 1.9 8.2 12.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PIEZO PF15917.5 CCM01766.1 - 9.8 5.6 11.2 17 4.8 11.2 1.3 1 0 0 1 1 1 0 Piezo PV-1 PF06637.11 CCM01767.1 - 0.0068 15.3 0.8 0.011 14.6 0.8 1.3 1 0 0 1 1 1 1 PV-1 protein (PLVAP) SKA2 PF16740.5 CCM01767.1 - 0.034 13.9 0.7 0.071 12.9 0.2 1.9 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF937 PF06078.11 CCM01767.1 - 0.039 14.6 2.8 0.04 14.5 0.2 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF937) DUF4515 PF14988.6 CCM01767.1 - 0.072 12.9 1.6 0.18 11.6 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) DGF-1_C PF11040.8 CCM01767.1 - 0.078 13.0 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Ribosomal_L29 PF00831.23 CCM01769.1 - 8e-18 64.2 2.5 8e-18 64.2 2.5 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein Phage_HK97_TLTM PF06120.11 CCM01769.1 - 0.029 13.6 3.7 0.035 13.3 3.7 1.1 1 0 0 1 1 1 0 Tail length tape measure protein MRP-L47 PF06984.13 CCM01769.1 - 0.029 14.5 2.4 0.033 14.3 0.8 1.8 2 0 0 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Annexin PF00191.20 CCM01769.1 - 0.084 13.0 1.2 0.18 11.9 0.1 1.9 2 0 0 2 2 2 0 Annexin Citrate_bind PF16114.5 CCM01769.1 - 0.11 12.0 1.1 0.82 9.2 1.1 2.0 1 1 0 1 1 1 0 ATP citrate lyase citrate-binding Snapin_Pallidin PF14712.6 CCM01769.1 - 0.39 11.2 11.2 1.9 8.9 2.8 2.1 1 1 1 2 2 2 0 Snapin/Pallidin PRKCSH-like PF12999.7 CCM01769.1 - 2.3 8.0 5.3 1.3 8.8 1.4 1.9 1 1 1 2 2 2 0 Glucosidase II beta subunit-like CCDC-167 PF15188.6 CCM01769.1 - 7.3 7.0 9.5 4.1 7.8 2.6 2.3 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Tetraspanin PF00335.20 CCM01771.1 - 2.8e-07 30.5 12.0 5.7e-07 29.5 12.0 1.5 1 1 0 1 1 1 1 Tetraspanin family DUF202 PF02656.15 CCM01771.1 - 0.00015 22.1 7.4 0.00052 20.4 0.1 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF202) RepA_N PF06970.11 CCM01771.1 - 0.082 12.9 0.0 2.2 8.3 0.0 2.6 2 0 0 2 2 2 0 Replication initiator protein A (RepA) N-terminus DUF5305 PF17231.2 CCM01771.1 - 0.33 10.3 1.7 2.1 7.7 0.0 2.4 2 1 1 3 3 3 0 Family of unknown function (DUF5305) DHHC PF01529.20 CCM01771.1 - 2.8 8.0 12.6 7.9 6.6 5.0 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF1129 PF06570.11 CCM01771.1 - 3.8 6.9 7.5 1.2 8.6 3.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) HKR_ArcB_TM PF18415.1 CCM01771.1 - 7.4 7.5 12.2 60 4.5 4.2 3.2 2 1 1 3 3 3 0 Histidine kinase receptor ArcB trans-membrane domain Hydrophobin PF01185.18 CCM01772.1 - 2.9e-13 50.3 5.5 4.7e-13 49.6 5.5 1.3 1 0 0 1 1 1 1 Fungal hydrophobin DUF2298 PF10060.9 CCM01772.1 - 0.12 11.1 1.3 0.14 10.8 1.3 1.0 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) DUF4799 PF16056.5 CCM01772.1 - 0.13 11.4 1.6 0.17 11.0 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4799) PHD PF00628.29 CCM01773.1 - 3.3e-07 30.1 1.1 3.3e-07 30.1 1.1 3.8 5 0 0 5 5 5 1 PHD-finger zf-UBR PF02207.20 CCM01773.1 - 8.7e-06 25.8 5.9 8.7e-06 25.8 5.9 3.6 3 1 1 4 4 4 1 Putative zinc finger in N-recognin (UBR box) ADH_N PF08240.12 CCM01773.1 - 0.063 13.2 1.5 1.3 9.0 0.1 2.4 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain Hydantoinase_B PF02538.14 CCM01774.1 - 1.2e-206 687.2 0.3 1.3e-206 687.0 0.3 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase DUF1744 PF08490.12 CCM01776.1 - 2.8e-136 454.3 0.0 5.6e-136 453.3 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 CCM01776.1 - 4.6e-72 243.0 0.0 7.2e-72 242.4 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 CCM01776.1 - 1.8e-10 40.1 0.1 4.5e-08 32.2 0.0 3.6 3 1 0 3 3 3 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 CCM01776.1 - 1.5e-08 34.6 0.8 6.3e-08 32.6 0.2 2.4 2 1 0 2 2 2 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 CCM01776.1 - 0.00088 19.3 0.0 0.0033 17.4 0.0 2.0 1 0 0 1 1 1 1 RNase_H superfamily zf-C4pol PF14260.6 CCM01776.1 - 0.12 12.8 7.8 0.51 10.9 7.8 2.1 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta LRRNT_2 PF08263.12 CCM01777.1 - 0.24 11.7 1.6 1 9.8 1.6 2.1 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain Acetyltransf_7 PF13508.7 CCM01778.1 - 1.7e-06 28.4 0.1 2.5e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM01778.1 - 0.00051 20.3 0.2 0.0024 18.1 0.0 1.8 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM01778.1 - 0.001 19.0 0.8 0.14 12.1 0.0 2.2 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain MAP65_ASE1 PF03999.12 CCM01779.1 - 1.3e-73 248.7 1.4 3.1e-68 231.0 0.0 2.5 2 1 0 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) Exonuc_VII_L PF02601.15 CCM01779.1 - 0.087 12.4 4.1 1.5 8.3 0.6 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit RIFIN PF02009.16 CCM01779.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Rifin Neogenin_C PF06583.12 CCM01779.1 - 0.73 9.6 15.0 0.016 15.0 6.9 2.1 2 1 0 2 2 2 0 Neogenin C-terminus Mucin PF01456.17 CCM01780.1 - 0.055 13.5 13.2 0.1 12.6 13.2 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Laminin_G_3 PF13385.6 CCM01781.1 - 2.3e-06 27.8 0.0 6.6e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4704 PF15787.5 CCM01781.1 - 0.00031 20.1 4.3 0.00054 19.3 0.7 3.0 4 0 0 4 4 4 1 Domain of unknown function (DUF4704) Beach PF02138.18 CCM01782.1 - 5.1e-106 354.1 0.0 6.7e-106 353.7 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 CCM01782.1 - 7.9e-07 29.1 0.1 1.5e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 CCM01782.1 - 6.7e-06 26.7 8.8 0.14 13.0 0.1 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat F-box PF00646.33 CCM01783.1 - 0.057 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 F-box domain Methyltransf_11 PF08241.12 CCM01784.1 - 1.7e-15 57.5 0.0 7.8e-11 42.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 CCM01784.1 - 8.5e-14 52.0 0.0 1.9e-11 44.5 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM01784.1 - 1.3e-07 31.6 0.0 2.2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM01784.1 - 3.7e-06 27.6 0.0 1.8e-05 25.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM01784.1 - 3.9e-05 23.1 0.0 0.00044 19.7 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CCM01784.1 - 5e-05 23.2 0.0 8.7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCM01784.1 - 0.017 14.7 0.0 0.38 10.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_4 PF02390.17 CCM01784.1 - 0.22 11.0 0.0 0.46 9.9 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase DUF4064 PF13273.6 CCM01785.1 - 0.47 10.7 7.7 2.2 8.6 4.5 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) PMI_typeI PF01238.21 CCM01786.1 - 6.8e-102 341.4 0.0 1.1e-101 340.8 0.0 1.3 1 0 0 1 1 1 1 Phosphomannose isomerase type I p450 PF00067.22 CCM01786.1 - 5.5e-54 183.6 0.0 8.3e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cupin_2 PF07883.11 CCM01786.1 - 5.3e-08 32.5 0.0 0.00046 19.8 0.0 2.7 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 CCM01786.1 - 0.0027 17.6 0.0 3 7.8 0.0 2.8 3 0 0 3 3 3 2 AraC-like ligand binding domain p450 PF00067.22 CCM01787.1 - 3.9e-51 174.2 0.0 4.9e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GAPT PF11770.8 CCM01787.1 - 0.045 13.6 0.1 0.49 10.3 0.0 2.3 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) Elongin_A PF06881.11 CCM01788.1 - 0.046 14.3 0.0 0.095 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A TIM PF00121.18 CCM01790.1 - 2.9e-85 285.5 0.5 2.6e-79 266.1 0.1 2.0 2 0 0 2 2 2 2 Triosephosphate isomerase CutC PF03932.14 CCM01790.1 - 0.12 11.9 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 CutC family 2OG-FeII_Oxy PF03171.20 CCM01792.1 - 5.7e-13 49.2 0.0 1.2e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 CCM01793.1 - 3.2e-13 50.0 0.0 6.2e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCM01793.1 - 2.1e-09 38.1 0.0 4.6e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal CPSase_L_D2 PF02786.17 CCM01794.1 - 1.9e-115 383.7 0.1 7.2e-84 280.5 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain GATase PF00117.28 CCM01794.1 - 8.5e-45 152.9 0.0 2.4e-44 151.4 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 CCM01794.1 - 2.4e-44 151.0 0.0 6.6e-44 149.5 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 CCM01794.1 - 1.2e-41 141.9 0.1 2.6e-41 140.8 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 CCM01794.1 - 2.5e-31 108.9 0.0 1.2e-30 106.7 0.0 2.2 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 CCM01794.1 - 2.4e-19 69.3 0.0 7.3e-19 67.8 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 CCM01794.1 - 1.4e-18 67.2 0.2 3.1e-10 39.9 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CCM01794.1 - 5.1e-17 62.0 0.1 8e-09 35.3 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CCM01794.1 - 7.2e-10 38.7 0.1 0.00013 21.7 0.0 2.7 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 CCM01794.1 - 3.4e-07 30.5 0.1 0.0027 17.8 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 CCM01794.1 - 1e-05 25.4 0.1 0.0011 18.8 0.0 2.8 2 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 CCM01794.1 - 0.00045 20.1 0.0 0.083 12.7 0.0 4.1 4 0 0 4 4 4 1 DJ-1/PfpI family GARS_A PF01071.19 CCM01794.1 - 0.0031 17.3 0.1 0.031 14.1 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.6 CCM01794.1 - 0.011 15.2 0.0 0.65 9.4 0.1 2.5 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.11 CCM01794.1 - 0.015 14.9 0.0 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 RimK-like ATP-grasp domain DUF1707 PF08044.11 CCM01794.1 - 1.4 9.1 4.0 2.1 8.5 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) ADH_zinc_N PF00107.26 CCM01795.1 - 9.7e-16 57.9 0.0 1.5e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM01795.1 - 5.3e-05 23.1 0.8 0.00018 21.3 0.8 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Pil1 PF13805.6 CCM01795.1 - 0.024 14.2 0.5 0.046 13.2 0.5 1.4 1 0 0 1 1 1 0 Eisosome component PIL1 EMP24_GP25L PF01105.24 CCM01796.1 - 2.9e-33 115.4 0.0 4e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Brix PF04427.18 CCM01797.1 - 1.2e-23 84.3 0.1 2e-23 83.5 0.1 1.4 1 0 0 1 1 1 1 Brix domain F-box PF00646.33 CCM01798.1 - 0.0006 19.6 1.8 0.00091 19.1 0.2 2.2 2 0 0 2 2 2 1 F-box domain AA_permease_2 PF13520.6 CCM01799.1 - 1.2e-57 195.7 54.3 1.4e-57 195.4 54.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCM01799.1 - 1.8e-11 43.3 43.9 3e-11 42.6 43.9 1.3 1 0 0 1 1 1 1 Amino acid permease WD40 PF00400.32 CCM01801.1 - 5.6e-10 39.7 5.6 0.56 11.2 0.1 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat COX6C PF02937.15 CCM01802.1 - 0.069 13.3 0.0 0.071 13.3 0.0 1.0 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc DUF1977 PF09320.11 CCM01803.1 - 7.6e-26 90.4 0.5 1.2e-25 89.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 CCM01803.1 - 8.6e-25 86.6 0.4 1.8e-24 85.6 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain Period_C PF12114.8 CCM01803.1 - 5.7 6.5 8.5 14 5.2 8.5 1.6 1 0 0 1 1 1 0 Period protein 2/3C-terminal region F-box-like PF12937.7 CCM01804.1 - 3.2e-08 33.3 0.0 8.2e-08 32.0 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM01804.1 - 8.2e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 F-box domain MIT PF04212.18 CCM01804.1 - 0.0018 18.3 0.0 0.0036 17.3 0.0 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain F-box_4 PF15966.5 CCM01804.1 - 0.0053 16.6 0.0 0.0094 15.8 0.0 1.3 1 0 0 1 1 1 1 F-box TPR_1 PF00515.28 CCM01804.1 - 0.082 12.8 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCM01804.1 - 0.18 11.5 0.1 2.1 8.1 0.0 2.3 1 1 1 2 2 2 0 TPR repeat KAR9 PF08580.10 CCM01805.1 - 2.4e-14 52.9 69.2 2.4e-14 52.9 69.2 5.4 1 1 2 4 4 4 2 Yeast cortical protein KAR9 FUSC PF04632.12 CCM01805.1 - 0.028 13.0 0.9 0.049 12.2 0.9 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Laminin_II PF06009.12 CCM01805.1 - 0.25 11.3 5.7 28 4.7 0.1 3.4 2 1 1 3 3 3 0 Laminin Domain II Jnk-SapK_ap_N PF09744.9 CCM01805.1 - 2.7 8.2 6.8 0.52 10.5 0.9 2.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Clr2_transil PF16761.5 CCM01806.1 - 1.2e-24 86.9 1.5 2.4e-24 85.9 1.5 1.6 1 0 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 Clr2 PF10383.9 CCM01806.1 - 9.2e-11 42.7 0.3 8.1e-09 36.4 0.0 3.3 2 1 0 2 2 2 1 Transcription-silencing protein Clr2 TPR_14 PF13428.6 CCM01807.1 - 3.5e-05 24.3 0.9 0.035 14.9 0.0 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM01807.1 - 4.5e-05 23.9 0.2 0.00015 22.2 0.0 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM01807.1 - 0.00061 19.7 0.0 0.13 12.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCM01807.1 - 0.0018 17.9 0.0 0.23 11.2 0.0 2.4 1 1 1 2 2 2 2 TPR repeat TPR_16 PF13432.6 CCM01807.1 - 0.0026 18.4 0.1 0.0026 18.4 0.1 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCM01807.1 - 0.019 15.3 0.4 1.5 9.4 0.0 3.4 4 1 0 4 4 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CCM01807.1 - 0.03 14.0 0.2 0.19 11.4 0.2 2.0 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 CCM01807.1 - 0.057 13.3 0.1 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01807.1 - 0.066 13.4 0.0 0.36 11.2 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCM01807.1 - 0.075 13.3 0.1 2.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCM01807.1 - 0.095 12.8 0.0 3.5 7.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat HemY_N PF07219.13 CCM01807.1 - 0.11 12.7 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 HemY protein N-terminus Transglut_prok PF09017.10 CCM01807.1 - 0.13 11.6 0.1 0.13 11.5 0.1 1.0 1 0 0 1 1 1 0 Microbial transglutaminase TPR_6 PF13174.6 CCM01807.1 - 0.14 12.8 0.0 16 6.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Vps5 PF09325.10 CCM01808.1 - 1.6e-67 227.5 3.7 2.1e-67 227.1 3.7 1.1 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CCM01808.1 - 5.1e-27 94.1 0.8 1e-25 89.9 0.2 2.3 2 0 0 2 2 2 1 PX domain BAR PF03114.18 CCM01808.1 - 7.4e-05 22.5 0.9 0.00013 21.8 0.9 1.2 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 CCM01808.1 - 0.00035 20.4 2.4 0.004 16.9 0.1 2.2 1 1 1 2 2 2 1 BAR domain of APPL family Arfaptin PF06456.13 CCM01808.1 - 0.001 18.7 1.3 0.0076 15.8 1.3 2.0 1 1 0 1 1 1 1 Arfaptin-like domain BAR_3_WASP_bdg PF10456.9 CCM01808.1 - 0.018 14.5 0.2 0.095 12.1 0.2 2.0 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein FAM92 PF06730.11 CCM01808.1 - 0.11 12.0 6.0 0.21 11.0 3.6 2.3 2 1 0 2 2 2 0 FAM92 protein CLZ PF16526.5 CCM01808.1 - 2.2 8.7 4.5 0.7 10.3 0.2 2.4 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DWNN PF08783.11 CCM01809.1 - 4.1e-25 87.8 0.1 1.1e-24 86.5 0.1 1.7 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 CCM01809.1 - 0.0045 16.8 1.0 0.008 16.0 1.0 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 CCM01809.1 - 0.0049 16.7 4.9 0.0083 16.0 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM01809.1 - 0.026 14.4 8.4 0.045 13.6 8.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCM01809.1 - 0.083 13.2 6.4 0.16 12.3 6.4 1.5 1 0 0 1 1 1 0 Ring finger domain zf_C2H2_10 PF18414.1 CCM01809.1 - 0.088 12.4 0.1 0.27 10.8 0.1 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger zf-RING_5 PF14634.6 CCM01809.1 - 0.19 11.7 6.9 0.37 10.8 6.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCM01809.1 - 0.4 10.8 6.0 0.75 9.9 6.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 CCM01809.1 - 0.61 10.0 5.2 2.2 8.2 5.2 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CCM01809.1 - 0.78 9.7 8.4 1.4 8.8 8.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ABC_tran_CTD PF16326.5 CCM01809.1 - 0.99 9.7 6.6 0.15 12.3 1.2 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain ERG4_ERG24 PF01222.17 CCM01810.1 - 1.1e-129 433.0 22.6 1.2e-129 432.8 22.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ICMT PF04140.14 CCM01810.1 - 0.00074 19.9 3.7 0.017 15.5 0.0 3.5 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM01810.1 - 0.0091 16.4 0.3 0.0091 16.4 0.3 3.8 3 2 1 4 4 4 1 Phospholipid methyltransferase DUF1295 PF06966.12 CCM01810.1 - 1.2 8.6 16.7 0.094 12.2 10.9 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1295) WD40 PF00400.32 CCM01811.1 - 9.5e-40 133.9 7.7 1.5e-07 32.0 0.1 7.9 7 1 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.11 CCM01811.1 - 7.9e-13 47.7 1.0 2e-12 46.4 1.0 1.8 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 CCM01811.1 - 9.8e-11 41.8 0.0 0.26 11.6 0.0 5.5 4 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCM01811.1 - 0.00072 19.0 0.0 0.53 9.6 0.0 3.4 4 0 0 4 4 4 1 WD40-like domain Ion_trans PF00520.31 CCM01811.1 - 0.0015 17.8 23.1 0.0027 17.0 23.1 1.4 1 0 0 1 1 1 1 Ion transport protein Ge1_WD40 PF16529.5 CCM01811.1 - 0.0094 14.9 0.0 14 4.5 0.0 3.7 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PKD_channel PF08016.12 CCM01811.1 - 0.0096 14.6 16.4 0.017 13.9 16.4 1.4 1 0 0 1 1 1 1 Polycystin cation channel Nbas_N PF15492.6 CCM01811.1 - 0.0097 15.3 0.1 9.8 5.4 0.0 3.1 3 0 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal LANC_like PF05147.13 CCM01811.1 - 0.15 10.6 0.0 0.25 9.9 0.0 1.2 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein Nup160 PF11715.8 CCM01811.1 - 0.15 10.6 1.0 17 3.9 0.1 3.3 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF4395 PF14340.6 CCM01811.1 - 0.6 10.5 10.0 1 9.7 9.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4395) PMT PF02366.18 CCM01812.1 - 4.6e-78 262.2 16.8 4.6e-78 262.2 16.8 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCM01812.1 - 6.1e-62 208.8 3.0 6.1e-62 208.8 3.0 3.5 2 1 1 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCM01812.1 - 8.7e-15 55.0 2.1 1.3e-14 54.5 2.1 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 CCM01812.1 - 0.0012 19.1 11.4 0.0012 19.1 11.4 2.6 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Ank_3 PF13606.6 CCM01813.1 - 5.1e-10 38.7 2.1 0.00078 19.7 0.1 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 CCM01813.1 - 1.5e-09 38.3 1.9 0.00018 22.1 1.3 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCM01813.1 - 1.6e-08 34.9 1.9 6.9e-06 26.5 0.7 2.9 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CCM01813.1 - 3.9e-07 30.2 6.6 0.0025 18.2 0.5 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 CCM01813.1 - 4.3e-06 26.9 4.5 0.075 13.4 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) KilA-N PF04383.13 CCM01813.1 - 8.7e-05 22.3 0.1 0.0024 17.7 0.1 2.4 1 1 0 1 1 1 1 KilA-N domain Filament PF00038.21 CCM01813.1 - 0.033 13.8 0.5 0.055 13.0 0.5 1.2 1 0 0 1 1 1 0 Intermediate filament protein PDH PF02153.17 CCM01813.1 - 0.14 11.2 0.0 0.25 10.3 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase PX PF00787.24 CCM01814.1 - 7.4e-16 58.1 0.0 2.5e-15 56.4 0.0 1.9 2 0 0 2 2 2 1 PX domain Peptidase_C101 PF16218.5 CCM01814.1 - 0.088 12.1 2.1 0.12 11.6 1.1 1.6 2 0 0 2 2 2 0 Peptidase family C101 TFIIS_M PF07500.14 CCM01815.1 - 2e-17 63.7 0.4 4e-17 62.7 0.4 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 CCM01815.1 - 6.7e-11 42.3 0.0 1.4e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 SPOC domain PHD PF00628.29 CCM01815.1 - 1.2e-06 28.3 3.6 2.1e-06 27.5 3.6 1.4 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 CCM01815.1 - 0.047 13.6 1.7 0.083 12.8 1.7 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) eIF3_subunit PF08597.10 CCM01815.1 - 1.7 8.5 14.4 0.14 12.1 2.8 2.7 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Pkinase PF00069.25 CCM01816.1 - 3.9e-71 239.5 0.0 7.4e-71 238.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01816.1 - 5.1e-54 183.3 0.0 7.8e-54 182.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 CCM01816.1 - 4e-09 36.2 2.2 6.8e-09 35.5 2.2 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CH PF00307.31 CCM01816.1 - 8.8e-09 35.5 0.0 1.7e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 CCM01816.1 - 0.00099 19.3 0.0 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin Zn_ribbon_17 PF17120.5 CCM01816.1 - 0.015 15.0 4.3 0.029 14.0 4.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type YrbL-PhoP_reg PF10707.9 CCM01816.1 - 0.022 14.3 0.1 0.04 13.4 0.1 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PHD PF00628.29 CCM01816.1 - 0.03 14.2 4.5 0.067 13.1 4.5 1.6 1 0 0 1 1 1 0 PHD-finger Kinase-like PF14531.6 CCM01816.1 - 0.039 13.3 0.0 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 CCM01816.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 CCM01816.1 - 0.17 10.9 0.1 0.28 10.2 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 C1_2 PF03107.16 CCM01816.1 - 0.25 11.7 1.6 0.55 10.6 1.6 1.5 1 0 0 1 1 1 0 C1 domain Prok-RING_1 PF14446.6 CCM01816.1 - 3.3 7.7 6.2 8.5 6.4 6.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 HEAT_EZ PF13513.6 CCM01817.1 - 5.8e-17 61.8 16.0 5e-06 26.9 0.1 9.9 9 1 1 10 10 10 4 HEAT-like repeat HEAT PF02985.22 CCM01817.1 - 2.5e-16 58.3 12.0 0.035 14.4 0.2 10.1 10 0 0 10 10 10 4 HEAT repeat HEAT_2 PF13646.6 CCM01817.1 - 5.4e-12 45.9 4.8 0.041 14.3 0.6 7.0 5 3 3 8 8 7 2 HEAT repeats IBN_N PF03810.19 CCM01817.1 - 7.4e-09 35.4 0.0 1.2e-07 31.5 0.0 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain IFRD PF05004.13 CCM01817.1 - 3.5e-07 29.6 0.6 0.01 14.9 0.0 4.0 3 1 1 4 4 4 2 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 CCM01817.1 - 1.5e-05 25.5 0.0 0.99 10.0 0.0 5.5 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CCM01817.1 - 3.3e-05 24.0 0.1 0.013 15.5 0.0 3.4 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 CCM01817.1 - 8.5e-05 22.4 0.1 0.35 10.6 0.0 4.2 4 1 1 5 5 5 1 rRNA processing/ribosome biogenesis CLASP_N PF12348.8 CCM01817.1 - 0.001 18.7 0.0 0.81 9.2 0.0 4.0 4 1 0 4 4 4 1 CLASP N terminal DUF3385 PF11865.8 CCM01817.1 - 0.0055 16.6 0.2 14 5.5 0.0 5.6 7 1 0 8 8 8 0 Domain of unknown function (DUF3385) UME PF08064.13 CCM01817.1 - 0.018 15.0 0.0 35 4.4 0.0 4.5 3 1 1 4 4 4 0 UME (NUC010) domain DRIM PF07539.12 CCM01817.1 - 0.032 12.6 0.1 18 3.5 0.0 3.9 4 1 0 4 4 4 0 Down-regulated in metastasis CAS_CSE1 PF03378.15 CCM01817.1 - 0.041 12.4 0.4 1.9 6.9 0.0 2.8 3 0 0 3 3 3 0 CAS/CSE protein, C-terminus MMS19_C PF12460.8 CCM01817.1 - 0.061 12.4 0.1 32 3.5 0.0 4.2 5 1 1 6 6 6 0 RNAPII transcription regulator C-terminal CTD_bind PF04818.13 CCM01817.1 - 0.15 12.9 0.2 72 4.3 0.0 4.7 4 1 1 5 5 4 0 RNA polymerase II-binding domain. Methyltransf_23 PF13489.6 CCM01818.1 - 3.4e-21 75.8 0.0 4.7e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM01818.1 - 2.2e-18 66.7 0.0 5.3e-18 65.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM01818.1 - 3.7e-14 53.3 0.0 7.9e-14 52.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM01818.1 - 6.6e-13 49.2 0.2 1.3e-11 45.0 0.2 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM01818.1 - 5.2e-12 45.8 0.1 4.3e-11 42.8 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CCM01818.1 - 2.4e-08 33.6 0.0 0.0012 18.2 0.0 2.1 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CCM01818.1 - 0.00024 20.6 0.0 0.0005 19.6 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 CCM01818.1 - 0.0064 16.1 0.0 0.18 11.4 0.0 2.1 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 CCM01818.1 - 0.012 15.6 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CCM01818.1 - 0.016 14.8 0.3 0.11 12.0 0.3 2.2 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 CCM01818.1 - 0.074 12.0 0.0 7 5.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) AdoMet_MTase PF07757.13 CCM01818.1 - 0.078 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_15 PF09445.10 CCM01818.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase CCDC144C PF14915.6 CCM01819.1 - 1.5e-07 30.9 0.5 2e-07 30.5 0.5 1.1 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region LMBR1 PF04791.16 CCM01819.1 - 0.018 14.0 0.6 0.021 13.8 0.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein BDV_P40 PF06407.11 CCM01819.1 - 0.02 14.0 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 Borna disease virus P40 protein Fib_alpha PF08702.10 CCM01819.1 - 0.021 15.0 0.7 0.032 14.4 0.7 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3584 PF12128.8 CCM01819.1 - 0.051 11.1 3.4 0.061 10.8 3.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Mce4_CUP1 PF11887.8 CCM01819.1 - 0.052 13.0 0.2 0.46 9.9 0.0 2.0 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative F_actin_bund_C PF18060.1 CCM01819.1 - 0.06 13.5 0.5 0.095 12.8 0.5 1.3 1 0 0 1 1 1 0 F actin bundling C terminal DUF724 PF05266.14 CCM01819.1 - 0.072 12.9 0.3 0.11 12.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 CCM01819.1 - 0.14 12.1 1.1 0.53 10.3 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Glyco_hydro_18 PF00704.28 CCM01821.1 - 1.8e-13 50.9 0.2 2.4e-13 50.5 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_18 PF00704.28 CCM01822.1 - 2.8e-15 56.9 4.0 6.4e-15 55.7 4.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 PRCC PF10253.9 CCM01822.1 - 0.17 12.7 1.6 0.27 12.0 1.6 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting N1221 PF07923.13 CCM01824.1 - 0.0036 16.5 0.1 2.4 7.3 0.0 2.1 2 0 0 2 2 2 2 N1221-like protein Telethonin PF09470.10 CCM01824.1 - 0.052 13.4 0.0 9 6.1 0.0 2.1 2 0 0 2 2 2 0 Telethonin protein COesterase PF00135.28 CCM01825.1 - 0.0008 18.4 0.2 0.005 15.8 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 CCM01826.1 - 1.5e-66 225.3 0.3 1.8e-66 225.1 0.3 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM01826.1 - 8.5e-08 32.3 0.9 0.011 15.6 0.2 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM01826.1 - 0.13 11.7 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family F-box-like PF12937.7 CCM01828.1 - 3.6e-11 42.8 0.7 1.8e-10 40.5 0.3 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM01828.1 - 0.0016 18.3 0.3 0.0016 18.3 0.3 4.1 5 0 0 5 5 5 1 F-box domain Pyr_redox_2 PF07992.14 CCM01829.1 - 2.1e-22 79.7 0.0 5.5e-21 75.1 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM01829.1 - 5.9e-12 46.0 0.0 1.2e-08 35.4 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM01829.1 - 7.7e-06 25.4 0.0 2e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM01829.1 - 0.0044 16.6 7.0 0.23 11.0 0.4 3.1 2 2 2 4 4 4 2 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CCM01829.1 - 0.0051 17.2 0.1 1.7 9.1 0.0 2.8 3 0 0 3 3 3 1 Putative NAD(P)-binding Lycopene_cycl PF05834.12 CCM01829.1 - 0.0051 15.9 0.0 1.9 7.4 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein K_oxygenase PF13434.6 CCM01829.1 - 0.0062 15.7 0.0 2.1 7.4 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 CCM01829.1 - 0.0065 15.4 0.3 0.76 8.6 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 CCM01829.1 - 0.009 16.2 0.1 2.1 8.6 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 CCM01829.1 - 0.012 15.9 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.6 CCM01829.1 - 0.095 12.7 0.9 1.3 8.9 0.0 2.9 3 1 1 4 4 4 0 FAD-NAD(P)-binding UQ_con PF00179.26 CCM01830.1 - 3.8e-16 59.0 0.0 4.1e-16 58.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCM01830.1 - 0.016 15.5 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 CCM01830.1 - 0.08 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 UEV domain VHS PF00790.19 CCM01831.1 - 7.2e-33 113.4 0.1 1.2e-32 112.7 0.1 1.3 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 CCM01831.1 - 6.4e-14 51.3 0.1 1.2e-13 50.5 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCM01831.1 - 1e-13 50.9 0.1 2.2e-13 49.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCM01831.1 - 1.5e-13 50.2 0.1 3.3e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 CCM01831.1 - 2.7e-11 43.6 0.5 6.4e-11 42.4 0.5 1.7 1 0 0 1 1 1 1 GAT domain UIM PF02809.20 CCM01831.1 - 0.0021 17.8 3.8 0.0021 17.8 3.8 1.9 2 0 0 2 2 2 1 Ubiquitin interaction motif Anoctamin PF04547.12 CCM01832.1 - 4.1e-97 325.8 1.7 4.9e-97 325.6 1.7 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Kinesin PF00225.23 CCM01834.1 - 2.4e-104 348.9 0.5 5.2e-104 347.8 0.5 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCM01834.1 - 8.9e-59 197.7 0.5 3.2e-58 195.9 0.0 2.2 2 1 0 2 2 2 1 Microtubule binding TMF_DNA_bd PF12329.8 CCM01834.1 - 0.0011 19.0 3.9 0.0011 19.0 3.9 4.1 2 1 1 3 3 3 1 TATA element modulatory factor 1 DNA binding FliD_N PF02465.18 CCM01834.1 - 0.0071 17.0 3.5 0.0071 17.0 3.5 4.2 4 1 0 4 4 4 1 Flagellar hook-associated protein 2 N-terminus RsgA_GTPase PF03193.16 CCM01834.1 - 0.084 12.8 1.9 1 9.3 0.4 3.1 2 1 0 2 2 2 0 RsgA GTPase ERM PF00769.19 CCM01834.1 - 0.11 12.3 39.4 0.29 10.9 39.4 1.7 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF3153 PF11353.8 CCM01834.1 - 0.7 9.4 7.1 0.32 10.5 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3153) EMP24_GP25L PF01105.24 CCM01834.1 - 1.1 9.2 7.8 0.65 9.9 3.5 2.4 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD zf-GRF PF06839.12 CCM01835.1 - 4.9e-11 42.5 4.6 3.3e-08 33.5 0.6 2.4 2 0 0 2 2 2 2 GRF zinc finger Exo_endo_phos PF03372.23 CCM01835.1 - 0.00063 19.3 0.1 0.0012 18.4 0.1 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CCM01835.1 - 0.013 15.3 0.0 0.26 11.2 0.0 2.6 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase zf-C2H2_jaz PF12171.8 CCM01836.1 - 7.8e-11 42.0 3.1 1.2e-10 41.4 3.1 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM01836.1 - 0.00072 19.9 1.5 0.0016 18.7 1.5 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCM01836.1 - 0.018 15.4 0.1 0.018 15.4 0.1 1.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) SH3_14 PF18343.1 CCM01837.1 - 0.049 13.7 0.0 0.066 13.3 0.0 1.2 1 0 0 1 1 1 0 Dda helicase SH3 domain DAP3 PF10236.9 CCM01839.1 - 7.5e-61 206.0 0.0 9.5e-61 205.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CCM01839.1 - 3.8e-06 27.4 0.0 5.7e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCM01839.1 - 0.00017 21.9 0.0 0.00047 20.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CCM01839.1 - 0.00028 20.9 0.0 0.00049 20.1 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CCM01839.1 - 0.0066 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein Rad17 PF03215.15 CCM01839.1 - 0.039 13.9 0.0 0.08 12.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_14 PF13173.6 CCM01839.1 - 0.072 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCM01839.1 - 0.14 12.7 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 CCM01839.1 - 0.17 11.5 0.0 0.34 10.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain F-box PF00646.33 CCM01840.1 - 0.00013 21.7 1.0 0.00013 21.7 1.0 4.0 5 0 0 5 5 5 2 F-box domain F-box-like PF12937.7 CCM01840.1 - 0.0002 21.2 3.1 0.00028 20.7 0.4 2.7 2 0 0 2 2 2 1 F-box-like Plus-3 PF03126.18 CCM01841.1 - 1.6e-31 109.1 2.4 6.2e-31 107.1 0.1 2.9 3 0 0 3 3 3 1 Plus-3 domain Aldo_ket_red PF00248.21 CCM01842.1 - 8.6e-69 232.0 0.0 9.8e-69 231.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CarboxypepD_reg PF13620.6 CCM01843.1 - 0.0044 17.2 1.8 0.01 16.1 1.8 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 CCM01843.1 - 0.0076 16.2 0.4 0.014 15.4 0.4 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain DUF4198 PF10670.9 CCM01843.1 - 0.012 16.0 0.4 0.018 15.4 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) Fe-S_biosyn PF01521.20 CCM01844.1 - 1.1e-20 73.9 0.0 1.4e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis HIG_1_N PF04588.13 CCM01845.1 - 2.4e-18 66.1 2.2 4.7e-18 65.1 2.2 1.5 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Urm1 PF09138.11 CCM01846.1 - 6.1e-33 113.1 0.0 5.2e-32 110.1 0.0 1.9 1 1 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 CCM01846.1 - 2.5e-05 24.8 0.1 3.8e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 ThiS family Cytochrome-c551 PF10643.9 CCM01847.1 - 0.079 12.5 4.5 3.2 7.3 0.1 2.2 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 BTB PF00651.31 CCM01848.1 - 2.7e-07 30.8 0.0 6.2e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Cupin_1 PF00190.22 CCM01850.1 - 2.8e-06 27.0 0.0 0.025 14.2 0.0 2.2 1 1 1 2 2 2 2 Cupin Cupin_2 PF07883.11 CCM01850.1 - 1.5e-05 24.6 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 2 Cupin domain XhlA PF10779.9 CCM01852.1 - 0.064 13.5 0.5 0.085 13.1 0.5 1.2 1 0 0 1 1 1 0 Haemolysin XhlA DUF812 PF05667.11 CCM01852.1 - 0.15 10.9 4.0 0.16 10.9 4.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) MFS_1 PF07690.16 CCM01857.1 - 2.2e-44 151.8 61.6 3.9e-42 144.5 60.0 3.1 2 1 0 2 2 2 2 Major Facilitator Superfamily tRNA-synt_1b PF00579.25 CCM01858.1 - 5.4e-62 209.8 0.0 5.5e-61 206.4 0.0 2.6 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) DnaJ-X PF14308.6 CCM01858.1 - 1.4e-52 178.3 1.6 1.4e-52 178.3 1.6 1.9 3 0 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.31 CCM01858.1 - 2.9e-25 88.1 5.5 3.4e-25 87.9 2.8 2.6 2 0 0 2 2 2 1 DnaJ domain BTB PF00651.31 CCM01859.1 - 2.6e-13 50.1 0.2 9e-13 48.4 0.2 2.0 1 0 0 1 1 1 1 BTB/POZ domain HATPase_c_3 PF13589.6 CCM01859.1 - 0.0096 15.8 2.0 5.4 6.8 0.2 3.3 2 2 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FtsJ PF01728.19 CCM01860.1 - 8.8e-41 139.9 0.0 1.2e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase CENP-T_C PF15511.6 CCM01861.1 - 4.4e-07 30.0 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 CCM01861.1 - 6.4e-05 23.1 0.1 9.1e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 CCM01861.1 - 0.00014 22.2 0.0 0.00018 21.8 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CCM01861.1 - 0.00098 19.4 0.1 0.0018 18.5 0.1 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM01861.1 - 0.0019 18.5 0.2 0.0022 18.4 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CCM01861.1 - 0.061 13.4 0.0 0.07 13.2 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIIIC_sub6 PF10419.9 CCM01862.1 - 3.6e-19 68.4 0.0 6.3e-19 67.6 0.0 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain ABC_tran PF00005.27 CCM01863.1 - 1.6e-47 161.4 0.0 5.7e-28 98.1 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCM01863.1 - 1.9e-47 162.2 34.1 3.2e-26 92.6 11.0 3.4 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 CCM01863.1 - 4.5e-09 36.1 0.5 0.13 11.7 0.0 4.3 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM01863.1 - 1.5e-08 35.4 0.5 0.00024 21.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 CCM01863.1 - 4.4e-08 33.3 2.6 0.0078 16.1 0.1 4.8 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM01863.1 - 4.5e-06 26.3 0.1 0.062 13.0 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM01863.1 - 2.5e-05 24.7 1.0 0.19 12.1 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 CCM01863.1 - 5.8e-05 23.2 0.4 0.19 11.8 0.0 3.5 4 0 0 4 4 3 2 50S ribosome-binding GTPase AAA_25 PF13481.6 CCM01863.1 - 0.00024 20.8 0.0 0.58 9.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 CCM01863.1 - 0.00042 19.5 0.0 0.047 12.7 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF87 PF01935.17 CCM01863.1 - 0.0011 19.1 0.5 0.15 12.1 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain IstB_IS21 PF01695.17 CCM01863.1 - 0.0013 18.5 0.0 2.4 7.9 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 CCM01863.1 - 0.0016 18.7 0.9 1 9.7 0.0 3.2 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCM01863.1 - 0.0016 18.4 0.1 0.85 9.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 CCM01863.1 - 0.0022 17.4 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family ATPase_2 PF01637.18 CCM01863.1 - 0.0057 16.6 0.0 0.41 10.5 0.0 2.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_15 PF13175.6 CCM01863.1 - 0.0075 16.0 0.1 0.32 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 CCM01863.1 - 0.0082 15.7 0.1 1.1 8.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region ResIII PF04851.15 CCM01863.1 - 0.01 15.8 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 CCM01863.1 - 0.017 15.1 0.3 9.3 6.3 0.1 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Adeno_IVa2 PF02456.15 CCM01863.1 - 0.023 13.5 0.0 0.3 9.8 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein DEAD PF00270.29 CCM01863.1 - 0.045 13.5 0.0 9.2 6.0 0.1 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase Pox_A32 PF04665.12 CCM01863.1 - 0.046 13.2 0.2 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_11 PF13086.6 CCM01863.1 - 0.05 13.4 0.2 0.25 11.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 CCM01863.1 - 0.057 13.6 0.1 19 5.5 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TrwB_AAD_bind PF10412.9 CCM01863.1 - 0.08 11.8 0.2 12 4.7 0.1 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 CCM01863.1 - 0.092 12.8 0.9 5.2 7.1 0.0 2.7 3 0 0 3 3 2 0 Dynamin family cobW PF02492.19 CCM01863.1 - 0.097 12.2 2.0 0.48 10.0 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CCM01863.1 - 0.13 12.8 0.0 33 5.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain Peptidase_M3 PF01432.20 CCM01864.1 - 1.2e-65 222.6 0.0 2.3e-65 221.7 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M3 Peptidase_M50B PF13398.6 CCM01864.1 - 0.00096 18.8 0.6 0.0017 18.0 0.6 1.3 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M2 PF01401.18 CCM01864.1 - 0.034 12.8 0.7 0.076 11.6 0.1 1.7 2 0 0 2 2 2 0 Angiotensin-converting enzyme HA2 PF04408.23 CCM01865.1 - 7.8e-26 90.5 3.1 1.3e-25 89.8 0.0 2.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCM01865.1 - 1.4e-19 70.2 0.0 4.2e-19 68.7 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCM01865.1 - 1.2e-11 44.9 1.6 9.1e-10 38.9 0.0 3.4 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CCM01865.1 - 3.6e-10 40.3 3.5 5.5e-05 23.5 0.0 4.3 4 0 0 4 4 4 3 AAA domain DEAD PF00270.29 CCM01865.1 - 8.4e-07 28.9 0.0 2.8e-06 27.2 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CCM01865.1 - 0.00015 21.6 0.1 0.031 14.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCM01865.1 - 0.0071 16.7 0.0 0.081 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CCM01865.1 - 0.011 15.8 5.1 0.26 11.4 0.0 3.3 3 0 0 3 3 2 0 AAA domain ATPase PF06745.13 CCM01865.1 - 0.013 14.9 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 KaiC Microtub_bd PF16796.5 CCM01865.1 - 0.015 15.2 1.2 2.8 7.9 0.7 2.5 2 0 0 2 2 2 0 Microtubule binding AAA_7 PF12775.7 CCM01865.1 - 0.039 13.5 0.1 4.8 6.7 0.0 3.1 3 0 0 3 3 3 0 P-loop containing dynein motor region TsaE PF02367.17 CCM01865.1 - 0.041 13.9 0.0 6.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 CCM01865.1 - 0.16 11.5 0.5 22 4.6 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 CCM01865.1 - 0.71 10.3 17.7 0.22 12.0 0.2 2.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCM01865.1 - 1.5 9.3 4.8 14 6.2 0.1 3.2 3 0 0 3 3 3 0 AAA domain SEN1_N PF12726.7 CCM01866.1 - 4.2e-159 531.2 0.0 5.7e-159 530.8 0.0 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 CCM01866.1 - 3.9e-70 236.6 0.5 1.1e-69 235.2 0.5 1.8 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CCM01866.1 - 1.2e-57 194.7 0.0 2.4e-57 193.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCM01866.1 - 4.1e-09 36.4 0.2 7e-05 22.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCM01866.1 - 2.5e-08 34.4 0.2 1.1e-07 32.3 0.1 2.2 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 CCM01866.1 - 0.00058 19.7 4.0 0.58 9.8 0.1 3.8 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 CCM01866.1 - 0.0047 16.9 0.0 1.9 8.4 0.0 3.6 3 1 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 CCM01866.1 - 0.0052 17.0 0.6 1.4 9.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCM01866.1 - 0.018 14.6 0.1 0.077 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 CCM01866.1 - 0.054 13.5 0.6 0.71 9.9 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 CCM01866.1 - 0.18 12.2 1.4 2.6 8.4 0.0 3.4 3 1 0 3 3 3 0 AAA ATPase domain Translin PF01997.16 CCM01867.1 - 2.9e-42 145.0 0.0 3.8e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 Translin family DUF1325 PF07039.11 CCM01868.1 - 5.8e-37 126.7 0.0 8.9e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 CCM01868.1 - 0.096 12.5 0.1 0.6 10.0 0.1 2.2 1 1 0 1 1 1 0 Lamin-B receptor of TUDOR domain HSP20 PF00011.21 CCM01869.1 - 9.8e-15 54.6 0.1 8.3e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCM01869.1 - 5.5e-11 41.9 0.0 2e-10 40.0 0.0 1.8 1 1 0 1 1 1 1 HSP20-like domain found in ArsA FKBP26_C PF18046.1 CCM01869.1 - 0.08 13.1 0.1 1.3 9.2 0.1 2.1 2 0 0 2 2 2 0 FKBP26_C-terminal CBFD_NFYB_HMF PF00808.23 CCM01870.1 - 5e-07 29.9 0.0 9.6e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM01870.1 - 0.03 14.7 1.0 0.75 10.2 0.0 2.3 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 tRNA_bind PF01588.20 CCM01871.1 - 3.7e-29 100.7 0.2 2.6e-28 98.0 0.0 2.1 2 0 0 2 2 2 1 Putative tRNA binding domain GST_C_3 PF14497.6 CCM01871.1 - 7.6e-07 29.3 1.2 9.6e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CCM01871.1 - 9.2e-07 29.0 0.4 3.2e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CCM01871.1 - 0.0099 15.7 1.3 0.014 15.1 0.3 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM01871.1 - 0.064 13.3 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF4670 PF15709.5 CCM01871.1 - 0.18 11.1 9.6 0.23 10.7 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4670) Ribosomal_L6 PF00347.23 CCM01872.1 - 1.7e-19 70.3 0.0 4.3e-10 40.1 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 Hydrolase_4 PF12146.8 CCM01873.1 - 0.018 14.3 0.2 0.14 11.4 0.1 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF1749 PF08538.10 CCM01873.1 - 0.085 11.9 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Peptidase_S9 PF00326.21 CCM01873.1 - 0.1 12.1 0.1 0.24 10.9 0.0 1.6 1 1 1 2 2 2 0 Prolyl oligopeptidase family DUF915 PF06028.11 CCM01873.1 - 0.11 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF1906 PF08924.11 CCM01873.1 - 0.15 12.2 0.1 0.23 11.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1906) vATP-synt_AC39 PF01992.16 CCM01874.1 - 2.6e-108 362.5 0.1 3.7e-108 362.0 0.1 1.2 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit TLP1_add_C PF18313.1 CCM01874.1 - 0.035 14.1 0.1 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Thiolase-like protein type 1 additional C-terminal domain CRAL_TRIO PF00650.20 CCM01875.1 - 9.5e-28 96.9 0.0 1.7e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCM01875.1 - 5.9e-09 36.0 0.3 2.2e-08 34.2 0.1 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain TFIIF_beta PF02270.15 CCM01875.1 - 0.098 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain ALMS_motif PF15309.6 CCM01875.1 - 1.2 9.6 7.3 6.8 7.2 4.4 2.3 2 0 0 2 2 2 0 ALMS motif Macoilin PF09726.9 CCM01875.1 - 2.4 6.6 8.7 3 6.3 8.7 1.1 1 0 0 1 1 1 0 Macoilin family Laps PF10169.9 CCM01875.1 - 3.1 8.4 6.6 10 6.7 6.6 1.8 1 1 0 1 1 1 0 Learning-associated protein DotD PF16816.5 CCM01876.1 - 0.11 12.5 0.0 0.51 10.3 0.0 2.1 2 0 0 2 2 2 0 DotD protein Gas_vesicle_C PF01304.17 CCM01876.1 - 9.6 6.3 6.8 0.52 10.4 0.2 2.1 2 0 0 2 2 2 0 Gas vesicles protein GVPc repeated domain zf-CCHC_3 PF13917.6 CCM01877.1 - 2.3e-19 69.1 1.1 3.8e-19 68.4 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle AF-4 PF05110.13 CCM01877.1 - 0.00023 19.5 16.1 0.00025 19.3 16.1 1.3 1 0 0 1 1 1 1 AF-4 proto-oncoprotein TFIIA PF03153.13 CCM01877.1 - 0.01 15.9 6.0 0.0099 15.9 6.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NAM-associated PF14303.6 CCM01877.1 - 0.019 15.7 6.8 0.027 15.2 6.8 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Cwf_Cwc_15 PF04889.12 CCM01877.1 - 0.06 13.1 13.6 0.07 12.9 13.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4746 PF15928.5 CCM01877.1 - 0.13 11.7 1.8 0.15 11.5 1.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Tmemb_cc2 PF10267.9 CCM01877.1 - 0.18 10.9 4.3 0.18 10.9 4.3 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Plasmodium_Vir PF05795.11 CCM01877.1 - 0.2 11.0 6.6 0.22 10.9 6.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TFIIF_alpha PF05793.12 CCM01877.1 - 0.2 10.2 15.9 0.23 10.0 15.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.9 CCM01877.1 - 0.22 11.1 17.5 0.29 10.7 17.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Astro_capsid_p PF12226.8 CCM01877.1 - 0.22 10.6 8.6 0.25 10.5 8.6 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 CCM01877.1 - 0.23 10.8 6.7 0.27 10.5 6.7 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 CCM01877.1 - 0.38 8.9 12.8 0.45 8.7 12.8 1.0 1 0 0 1 1 1 0 Nop14-like family Menin PF05053.13 CCM01877.1 - 0.52 8.6 5.8 0.62 8.4 5.8 1.0 1 0 0 1 1 1 0 Menin Afi1 PF07792.12 CCM01877.1 - 1.1 9.7 8.5 1.6 9.2 8.5 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nucleo_P87 PF07267.11 CCM01877.1 - 1.4 7.7 7.2 1.4 7.7 7.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Macoilin PF09726.9 CCM01877.1 - 1.8 7.1 7.0 1.8 7.0 7.0 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 CCM01877.1 - 2 7.1 7.6 2.2 7.0 7.6 1.1 1 0 0 1 1 1 0 Presenilin Atrophin-1 PF03154.15 CCM01877.1 - 2.3 6.4 13.3 2.4 6.3 13.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF4692 PF15763.5 CCM01877.1 - 3.6 8.0 8.8 5.9 7.3 8.8 1.4 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Orthopox_A36R PF05950.11 CCM01877.1 - 4 7.6 7.9 5.7 7.1 7.9 1.2 1 0 0 1 1 1 0 Orthopoxvirus A36R protein Apt1 PF10351.9 CCM01877.1 - 5.3 5.8 12.1 6 5.6 12.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF515 PF04415.12 CCM01877.1 - 5.4 5.3 9.6 6.7 5.0 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) RAP1 PF07218.11 CCM01877.1 - 6 5.0 9.6 7 4.8 9.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) FancD2 PF14631.6 CCM01877.1 - 6.5 4.0 6.9 7.3 3.9 6.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Paf1 PF03985.13 CCM01877.1 - 6.7 5.6 13.1 7.7 5.4 13.1 1.1 1 0 0 1 1 1 0 Paf1 NPR3 PF03666.13 CCM01877.1 - 7.3 5.3 11.5 9.3 4.9 11.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 CCM01877.1 - 7.6 4.7 11.7 9 4.4 11.7 1.1 1 0 0 1 1 1 0 CDC45-like protein ATP-synt_C PF00137.21 CCM01878.1 - 4e-30 103.9 32.8 4.4e-18 65.4 12.4 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Pkinase PF00069.25 CCM01879.1 - 9.8e-52 175.9 0.0 1.6e-51 175.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HpcH_HpaI PF03328.14 CCM01879.1 - 1.9e-40 138.4 0.0 4.3e-40 137.2 0.0 1.6 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Pkinase_Tyr PF07714.17 CCM01879.1 - 1.1e-22 80.6 0.0 8.1e-22 77.7 0.0 2.2 3 0 0 3 3 3 1 Protein tyrosine kinase C-C_Bond_Lyase PF15617.6 CCM01879.1 - 2.1e-10 40.3 0.2 6.6e-07 28.8 0.1 2.2 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold RIO1 PF01163.22 CCM01879.1 - 0.025 14.2 0.6 0.077 12.6 0.2 2.0 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.14 CCM01879.1 - 0.053 12.9 0.2 0.13 11.6 0.2 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCM01879.1 - 0.13 11.8 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CCM01879.1 - 1.6 7.4 3.5 0.63 8.7 0.1 1.8 2 0 0 2 2 2 0 Fungal protein kinase Abhydrolase_1 PF00561.20 CCM01880.1 - 5.9e-23 81.8 0.2 9.6e-22 77.9 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM01880.1 - 3.8e-11 42.7 0.2 3.4e-10 39.6 0.2 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM01880.1 - 1.2e-09 39.1 0.0 1.6e-09 38.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CCM01880.1 - 4.4e-06 26.5 0.0 7.9e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Thioesterase PF00975.20 CCM01880.1 - 0.021 14.9 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain BAAT_C PF08840.11 CCM01880.1 - 0.036 14.0 0.0 0.24 11.3 0.0 2.0 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 CCM01880.1 - 0.071 12.8 0.0 1.2 8.7 0.0 2.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DUF915 PF06028.11 CCM01880.1 - 0.17 11.2 0.2 0.46 9.8 0.1 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) HA2 PF04408.23 CCM01881.1 - 1.2e-21 77.1 0.0 1.2e-21 77.1 0.0 4.0 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CCM01881.1 - 5.7e-20 71.5 0.4 1.4e-19 70.2 0.4 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CCM01881.1 - 3.7e-15 56.2 0.0 1e-14 54.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCM01881.1 - 8.7e-07 28.9 0.2 4.5e-06 26.5 0.0 2.3 2 1 1 3 3 3 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CCM01881.1 - 0.00012 21.9 0.0 0.00026 20.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCM01881.1 - 0.00027 21.2 0.0 0.0012 19.1 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM01881.1 - 0.0043 17.4 0.1 0.0043 17.4 0.1 2.2 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 CCM01881.1 - 0.023 13.7 0.0 0.05 12.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AhpC-TSA PF00578.21 CCM01882.1 - 1.1e-17 64.1 0.0 7.1e-17 61.5 0.0 1.9 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCM01882.1 - 2e-09 37.3 0.0 2.7e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 CCM01882.1 - 0.013 15.6 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme DAHP_synth_1 PF00793.20 CCM01883.1 - 1.2e-95 319.6 0.0 1.5e-95 319.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family AMP-binding PF00501.28 CCM01886.1 - 1.4e-65 221.5 0.0 1.8e-65 221.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM01886.1 - 6.1e-08 33.5 0.0 1.4e-07 32.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain UPF0542 PF15086.6 CCM01886.1 - 0.01 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 DUF3243 PF11588.8 CCM01886.1 - 0.16 12.3 0.0 10 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3243) Questin_oxidase PF14027.6 CCM01887.1 - 1.9e-87 294.0 0.0 2.2e-87 293.8 0.0 1.0 1 0 0 1 1 1 1 Questin oxidase-like Epimerase PF01370.21 CCM01888.1 - 1e-22 80.8 0.0 1.4e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM01888.1 - 1.4e-14 53.8 0.0 2.3e-14 53.1 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM01888.1 - 8.7e-11 41.5 0.2 1.3e-09 37.6 0.2 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCM01888.1 - 3.2e-10 40.2 0.6 5.1e-10 39.5 0.6 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCM01888.1 - 6.9e-10 38.8 0.2 5.5e-09 35.9 0.1 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCM01888.1 - 0.00022 20.9 0.4 0.00038 20.1 0.2 1.4 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCM01888.1 - 0.00032 20.2 0.6 0.00091 18.7 0.6 1.9 1 1 0 1 1 1 1 short chain dehydrogenase GTP_EFTU PF00009.27 CCM01889.1 - 2e-58 197.1 0.1 3.7e-58 196.3 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CCM01889.1 - 1.9e-16 59.8 0.0 4.8e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 CCM01889.1 - 1.5e-05 25.0 0.1 4.1e-05 23.6 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CCM01889.1 - 2.5e-05 24.6 0.0 5.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 SRPRB PF09439.10 CCM01889.1 - 0.049 13.1 0.1 0.25 10.8 0.1 2.0 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit RasGEF PF00617.19 CCM01890.1 - 9.4e-51 172.5 0.3 1.4e-50 171.9 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCM01890.1 - 1e-18 67.5 0.0 3.9e-18 65.6 0.0 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif Stm1_N PF09598.10 CCM01890.1 - 1 10.2 3.2 3.4 8.6 3.2 2.0 1 1 0 1 1 1 0 Stm1 SH3_1 PF00018.28 CCM01891.1 - 3.7e-16 58.4 0.2 1.3e-15 56.7 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CCM01891.1 - 2.1e-12 46.7 1.4 1.4e-11 44.1 0.1 2.3 2 0 0 2 2 2 1 Variant SH3 domain WW PF00397.26 CCM01891.1 - 1.3e-10 41.2 0.2 0.00063 19.8 0.0 2.6 2 0 0 2 2 2 2 WW domain SH3_2 PF07653.17 CCM01891.1 - 4.7e-10 39.0 0.0 1.1e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Apolipoprotein PF01442.18 CCM01891.1 - 0.031 14.1 0.5 0.031 14.1 0.5 2.4 4 0 0 4 4 4 0 Apolipoprotein A1/A4/E domain DASH_Dad1 PF08649.10 CCM01892.1 - 1.1e-23 83.2 0.4 1.6e-23 82.6 0.4 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dad4 PF08650.10 CCM01892.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad4 Pkinase PF00069.25 CCM01893.1 - 3.4e-56 190.5 0.0 1.2e-55 188.8 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01893.1 - 7.9e-29 100.7 0.0 1e-27 97.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 CCM01893.1 - 1.3e-22 79.7 9.4 4.6e-12 45.9 5.3 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 CCM01893.1 - 8.2e-20 70.4 27.4 1e-11 44.5 10.3 2.3 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 CCM01893.1 - 6.5e-10 39.5 1.4 2.5e-09 37.7 1.4 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 CCM01893.1 - 3.7e-06 27.2 0.0 6.8e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain FTA2 PF13095.6 CCM01893.1 - 0.055 13.1 0.2 1.2 8.8 0.1 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PAXIP1_C PF15364.6 CCM01893.1 - 0.079 13.3 0.1 0.47 10.8 0.1 2.3 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein Kinase-like PF14531.6 CCM01893.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Kinase-like C1_2 PF03107.16 CCM01893.1 - 1.2 9.6 22.2 2.9 8.3 8.1 2.4 2 0 0 2 2 2 0 C1 domain Endosulfine PF04667.17 CCM01894.1 - 9.9e-26 89.7 0.1 1.8e-25 88.9 0.1 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region BNIP2 PF12496.8 CCM01894.1 - 7 7.1 10.0 2.7 8.4 3.2 2.4 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CwfJ_C_2 PF04676.14 CCM01895.1 - 4.5e-35 120.5 0.2 3.3e-34 117.7 0.0 2.3 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 CCM01895.1 - 4.3e-31 107.3 0.0 6.8e-31 106.7 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DNA_pol_E_B PF04042.16 CCM01895.1 - 1.3e-28 99.8 0.2 2.2e-28 99.0 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 CCM01895.1 - 5.6e-19 69.1 0.7 7.3e-08 32.7 0.0 3.3 2 1 1 3 3 3 2 DNA polymerase alpha subunit B N-terminal Herpes_U47 PF05467.11 CCM01895.1 - 0.51 8.4 2.0 0.76 7.8 2.0 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 cobW PF02492.19 CCM01896.1 - 2.4e-46 157.6 0.4 3.3e-46 157.1 0.4 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 CCM01896.1 - 3e-06 26.9 0.1 0.0029 17.2 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain CobW_C PF07683.14 CCM01896.1 - 3.1e-06 27.0 0.0 6.9e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 CCM01896.1 - 6.5e-05 22.9 0.1 0.098 12.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CCM01896.1 - 0.0003 20.8 0.0 0.00095 19.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CCM01896.1 - 0.0027 18.0 0.0 0.0058 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCM01896.1 - 0.0045 17.1 0.4 0.011 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CCM01896.1 - 0.0078 16.8 0.4 0.062 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 CCM01896.1 - 0.009 15.0 1.1 0.26 10.2 0.0 3.1 4 0 0 4 4 4 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Rad17 PF03215.15 CCM01896.1 - 0.033 14.1 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Arf PF00025.21 CCM01896.1 - 0.096 12.1 0.4 4 6.8 0.1 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family Viral_helicase1 PF01443.18 CCM01896.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DSPc PF00782.20 CCM01897.1 - 1.3e-27 96.2 0.0 1.8e-27 95.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 CCM01897.1 - 0.0018 18.5 0.0 0.0028 17.9 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 CCM01897.1 - 0.057 13.4 0.1 0.15 12.0 0.1 1.6 1 1 0 1 1 1 0 Tyrosine phosphatase family UAA PF08449.11 CCM01898.1 - 4e-43 147.7 5.7 5.7e-43 147.2 5.7 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCM01898.1 - 9.4e-09 35.6 21.5 8.1e-07 29.3 9.1 3.4 2 2 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 CCM01898.1 - 0.00022 20.3 3.9 0.051 12.5 0.2 2.1 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like Nuc_sug_transp PF04142.15 CCM01898.1 - 0.00039 19.7 2.8 0.14 11.2 0.5 2.2 1 1 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.16 CCM01898.1 - 0.003 17.0 3.1 0.33 10.2 0.3 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family Yae1_N PF09811.9 CCM01899.1 - 6e-10 38.7 2.0 7e-10 38.5 0.9 1.7 2 0 0 2 2 2 1 Essential protein Yae1, N terminal MtrG PF04210.13 CCM01899.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G FAD_binding_1 PF00667.20 CCM01900.1 - 5e-55 186.5 0.0 4.3e-54 183.4 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CCM01900.1 - 7.7e-29 100.7 0.2 1.7e-28 99.6 0.2 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CCM01900.1 - 9.8e-22 77.7 0.0 3.3e-21 76.0 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain She9_MDM33 PF05546.11 CCM01901.1 - 6.7e-76 254.5 9.6 9.1e-76 254.1 9.6 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family Peptidase_S46 PF10459.9 CCM01901.1 - 0.025 13.2 5.8 0.03 13.0 5.8 1.2 1 0 0 1 1 1 0 Peptidase S46 CBFD_NFYB_HMF PF00808.23 CCM01902.1 - 1.8e-11 44.1 1.0 2.7e-11 43.6 1.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM01902.1 - 1.9e-06 28.3 2.1 2.8e-06 27.7 2.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CCM01902.1 - 0.012 15.7 0.1 0.017 15.3 0.1 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Borrelia_REV PF03978.13 CCM01902.1 - 0.11 12.4 0.1 0.16 11.9 0.1 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein MMS1_N PF10433.9 CCM01903.1 - 3.8e-64 217.1 0.0 6.1e-64 216.4 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CCM01903.1 - 6.9e-49 166.9 0.0 3.2e-32 112.1 0.0 3.4 4 0 0 4 4 4 2 CPSF A subunit region Na_Ca_ex PF01699.24 CCM01904.1 - 2.4e-17 63.3 35.2 2.6e-11 43.7 12.9 3.5 4 1 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 CCM01904.1 - 1.7e-14 54.2 14.8 1.7e-14 54.2 14.8 3.6 2 0 0 2 2 2 1 Inner membrane component domain SLATT_5 PF18160.1 CCM01904.1 - 0.26 10.6 0.5 0.95 8.8 0.5 2.0 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DMAP_binding PF06464.11 CCM01905.1 - 0.015 16.1 0.6 0.067 14.0 0.0 2.5 2 0 0 2 2 2 0 DMAP1-binding Domain ERG4_ERG24 PF01222.17 CCM01906.1 - 1.2e-134 449.3 10.6 1.5e-134 449.0 10.6 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCM01906.1 - 5.1e-06 26.2 0.3 5.1e-06 26.2 0.3 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCM01906.1 - 0.00091 19.6 1.0 0.0077 16.6 0.0 2.7 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM01906.1 - 0.0014 19.0 0.0 0.0014 19.0 0.0 3.0 4 0 0 4 4 4 1 Phospholipid methyltransferase GPI-anchored PF10342.9 CCM01907.1 - 3.3e-06 27.7 0.2 5e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.6 CCM01907.1 - 0.04 13.7 0.1 0.049 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SUR7 PF06687.12 CCM01908.1 - 1.3e-05 24.9 19.6 0.0069 16.0 19.6 2.2 1 1 0 1 1 1 1 SUR7/PalI family Claudin_3 PF06653.11 CCM01908.1 - 0.031 14.2 12.4 0.087 12.8 12.4 1.7 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Whi5 PF08528.11 CCM01909.1 - 0.00077 19.0 0.4 0.0014 18.2 0.4 1.4 1 0 0 1 1 1 1 Whi5 like ABATE PF07336.11 CCM01910.1 - 0.23 12.1 4.9 0.076 13.7 0.6 2.4 2 0 0 2 2 2 0 Putative stress-induced transcription regulator DUF2415 PF10313.9 CCM01911.1 - 1.7e-08 34.3 0.0 5.4e-08 32.6 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) PD40 PF07676.12 CCM01911.1 - 0.13 12.2 0.9 20 5.3 0.1 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CCM01911.1 - 0.38 9.7 0.8 1.7 7.5 0.1 2.3 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 CCM01911.1 - 0.4 11.6 5.2 67 4.6 0.1 5.5 7 0 0 7 7 7 0 WD domain, G-beta repeat zf-C2H2 PF00096.26 CCM01912.1 - 2.7e-10 40.1 14.9 0.0035 17.7 0.1 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM01912.1 - 9.4e-08 32.2 11.8 0.0021 18.4 0.2 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCM01912.1 - 3.9e-07 30.4 12.9 0.037 14.9 0.1 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 CCM01912.1 - 0.0053 17.1 1.0 1 9.8 0.0 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CCM01912.1 - 0.007 16.3 2.4 0.4 10.8 0.1 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CCM01912.1 - 0.028 14.7 2.2 0.079 13.3 2.1 1.8 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2HE PF16278.5 CCM01912.1 - 0.055 13.9 2.2 7.6 7.1 0.9 2.5 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 CCM01912.1 - 0.35 11.2 4.2 1.1 9.7 0.0 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 CCM01912.1 - 1.8 8.4 6.6 1.8 8.4 0.0 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type FOXP-CC PF16159.5 CCM01912.1 - 5.1 7.8 9.2 3.2 8.4 4.5 2.6 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2HC_2 PF13913.6 CCM01912.1 - 9.3 6.3 6.7 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type MMR_HSR1 PF01926.23 CCM01913.1 - 3.6e-09 36.7 1.1 1.9e-08 34.4 0.1 2.2 1 1 1 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCM01913.1 - 3.6e-08 33.0 1.1 1.7e-06 27.5 0.0 2.3 1 1 1 2 2 2 1 AIG1 family Dynamin_N PF00350.23 CCM01913.1 - 4.8e-06 26.7 8.6 0.014 15.4 0.1 3.2 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 CCM01913.1 - 0.00031 20.3 0.2 0.00081 19.0 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCM01913.1 - 0.00046 20.1 0.6 0.00046 20.1 0.6 2.3 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 CCM01913.1 - 0.0033 16.7 1.4 0.004 16.5 0.1 1.8 2 1 0 2 2 2 1 Septin TPR_14 PF13428.6 CCM01913.1 - 0.013 16.3 2.3 1.2 10.1 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat AAA_22 PF13401.6 CCM01913.1 - 0.015 15.5 1.1 0.55 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCM01913.1 - 0.02 15.4 1.9 0.05 14.1 0.2 2.2 2 0 0 2 2 2 0 ABC transporter IIGP PF05049.13 CCM01913.1 - 0.033 13.2 0.1 0.069 12.2 0.1 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Spc7 PF08317.11 CCM01913.1 - 0.12 11.2 6.9 0.18 10.6 6.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 CCM01913.1 - 0.27 10.8 5.0 0.41 10.2 5.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 CCM01913.1 - 0.29 9.6 4.0 0.36 9.3 4.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.9 CCM01913.1 - 0.43 9.6 8.7 0.71 8.9 8.7 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fzo_mitofusin PF04799.13 CCM01913.1 - 0.46 10.0 3.8 0.86 9.1 3.8 1.4 1 0 0 1 1 1 0 fzo-like conserved region AAA_23 PF13476.6 CCM01913.1 - 0.48 10.9 14.7 25 5.3 14.7 2.8 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 CCM01913.1 - 0.5 10.4 6.4 3.2 7.8 1.6 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain DUF883 PF05957.13 CCM01913.1 - 0.74 10.5 6.5 2 9.1 6.5 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) AAA_16 PF13191.6 CCM01913.1 - 0.82 10.0 6.0 3.7 7.9 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain Tho2 PF11262.8 CCM01913.1 - 1 8.5 4.5 1.4 8.0 4.5 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF724 PF05266.14 CCM01913.1 - 2.7 7.8 8.3 4.1 7.2 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) MDMPI_N PF11716.8 CCM01913.1 - 2.7 8.7 5.1 4.3 8.0 5.1 1.4 1 1 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain MMR_HSR1 PF01926.23 CCM01914.1 - 3.1e-12 46.6 0.1 6.1e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCM01914.1 - 2.8e-08 33.4 0.2 4.6e-08 32.7 0.1 1.5 1 1 0 1 1 1 1 AIG1 family Septin PF00735.18 CCM01914.1 - 1.4e-07 31.1 0.0 3.1e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Septin Dynamin_N PF00350.23 CCM01914.1 - 7.7e-06 26.1 1.4 0.078 13.0 0.0 2.9 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 CCM01914.1 - 1.5e-05 24.5 0.0 3.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCM01914.1 - 3.1e-05 23.9 0.4 7.4e-05 22.7 0.1 1.7 2 0 0 2 2 1 1 RsgA GTPase AAA_22 PF13401.6 CCM01914.1 - 4.5e-05 23.7 1.2 0.00019 21.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 CCM01914.1 - 0.00046 19.3 0.1 0.00095 18.3 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_18 PF13238.6 CCM01914.1 - 0.00073 20.1 0.4 0.0017 18.9 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCM01914.1 - 0.00083 19.8 1.5 0.015 15.7 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CCM01914.1 - 0.0011 19.6 0.1 0.0011 19.6 0.1 2.4 2 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 CCM01914.1 - 0.0021 18.0 0.1 0.0069 16.3 0.1 1.9 1 0 0 1 1 1 1 NTPase AAA PF00004.29 CCM01914.1 - 0.003 18.0 0.0 0.0066 16.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 CCM01914.1 - 0.0038 17.0 0.6 0.31 10.8 0.2 2.5 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 CCM01914.1 - 0.0061 16.0 0.4 0.011 15.1 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit FAM184 PF15665.5 CCM01914.1 - 0.0073 16.1 6.6 0.012 15.4 6.6 1.2 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B AAA_19 PF13245.6 CCM01914.1 - 0.011 16.1 0.1 0.03 14.7 0.1 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCM01914.1 - 0.014 15.9 0.4 0.054 14.0 0.0 2.1 2 1 0 2 2 2 0 ABC transporter TsaE PF02367.17 CCM01914.1 - 0.02 14.9 0.3 0.051 13.6 0.1 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IIGP PF05049.13 CCM01914.1 - 0.022 13.9 0.1 0.044 12.8 0.1 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 CCM01914.1 - 0.022 14.5 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 CCM01914.1 - 0.025 14.6 0.0 0.075 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain RL10P_insert PF17777.1 CCM01914.1 - 0.032 14.2 0.0 0.11 12.5 0.0 2.0 1 0 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P NB-ARC PF00931.22 CCM01914.1 - 0.036 13.3 0.0 0.082 12.1 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 CCM01914.1 - 0.05 13.2 0.1 0.13 11.8 0.1 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 CCM01914.1 - 0.052 13.3 1.3 0.14 11.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCM01914.1 - 0.065 13.0 0.1 0.14 11.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCM01914.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 CCM01914.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CCM01914.1 - 0.13 12.7 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase YtxH PF12732.7 CCM01914.1 - 0.14 12.7 0.8 1.1 9.9 0.4 2.2 2 0 0 2 2 2 0 YtxH-like protein AAA_11 PF13086.6 CCM01914.1 - 0.18 11.5 1.7 12 5.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF745 PF05335.13 CCM01914.1 - 0.19 11.4 2.3 0.34 10.6 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) AAA_28 PF13521.6 CCM01914.1 - 0.36 11.1 2.9 1.1 9.5 0.2 2.8 3 1 0 3 3 3 0 AAA domain Csm1_N PF18504.1 CCM01914.1 - 0.45 10.9 4.3 1.3 9.4 2.3 2.4 1 1 1 2 2 2 0 Csm1 N-terminal domain CENP-F_leu_zip PF10473.9 CCM01914.1 - 3.9 7.5 14.5 42 4.2 13.4 2.7 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RAI1 PF08652.11 CCM01915.1 - 4.4e-21 74.8 0.0 8.1e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease zf_CCCH_5 PF18384.1 CCM01915.1 - 0.16 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Unkempt Zinc finger domain 1 (Znf1) TPR_1 PF00515.28 CCM01916.1 - 3.2e-13 48.9 0.7 1.7e-05 24.5 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCM01916.1 - 1.1e-11 43.8 5.7 0.00022 21.1 0.1 4.9 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCM01916.1 - 5.5e-09 36.5 6.8 2.7e-06 27.9 0.2 4.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM01916.1 - 1.7e-07 31.5 10.0 0.012 16.4 0.1 5.5 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCM01916.1 - 2.5e-06 27.1 0.6 0.85 9.8 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM01916.1 - 3e-06 27.0 1.4 0.099 12.9 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCM01916.1 - 1e-05 26.0 8.0 0.00047 20.6 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCM01916.1 - 2.6e-05 23.8 0.2 0.0029 17.3 0.2 2.8 1 1 1 2 2 2 1 TPR repeat TPR_12 PF13424.6 CCM01916.1 - 0.00012 22.3 10.9 2.8 8.3 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 CCM01916.1 - 0.00028 20.2 3.7 0.13 11.5 0.4 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCM01916.1 - 0.00039 20.6 3.5 0.33 11.4 0.0 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCM01916.1 - 0.023 14.8 2.3 0.66 10.2 0.4 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM01916.1 - 0.025 14.8 0.2 0.062 13.5 0.2 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CCM01916.1 - 0.028 14.7 0.6 0.37 11.2 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCM01916.1 - 0.062 13.2 6.0 2.3 8.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Retrotran_gag_2 PF14223.6 CCM01916.1 - 0.15 11.7 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type ILVD_EDD PF00920.21 CCM01917.1 - 3.1e-200 666.2 0.0 3.5e-200 666.0 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family TNFR_16_TM PF18422.1 CCM01918.1 - 0.19 11.7 0.2 0.32 11.0 0.2 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain AIM24 PF01987.17 CCM01919.1 - 1.8e-47 161.8 0.1 2e-47 161.6 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Ank_2 PF12796.7 CCM01921.1 - 2.1e-08 34.6 0.0 4.2e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM01921.1 - 1.6e-07 31.5 1.3 4.4e-06 26.9 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM01921.1 - 2.6e-07 30.4 0.1 0.0053 17.2 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 CCM01921.1 - 7.7e-07 29.6 0.2 0.00028 21.4 0.1 3.7 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 CCM01921.1 - 9e-06 25.9 0.7 0.076 13.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat TIG PF01833.24 CCM01921.1 - 0.023 14.8 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 IPT/TIG domain GST_N PF02798.20 CCM01922.1 - 2.2e-16 59.9 0.1 4.2e-15 55.9 0.0 2.4 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCM01922.1 - 8.2e-14 51.8 0.0 1.5e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM01922.1 - 2e-13 50.4 0.0 2.9e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCM01922.1 - 5.3e-10 39.4 0.0 1.9e-09 37.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCM01922.1 - 1.2e-06 28.6 0.0 2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM01922.1 - 0.0002 21.3 0.0 0.00038 20.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCM01923.1 - 2.9e-18 66.0 0.0 4.2e-17 62.2 0.0 2.4 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCM01923.1 - 1.1e-15 57.8 0.0 1.8e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM01923.1 - 4.8e-12 46.0 0.0 1.4e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM01923.1 - 1.5e-09 37.9 0.0 2.2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCM01923.1 - 2.9e-06 27.4 0.0 4.8e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM01923.1 - 0.0028 17.6 0.0 0.0068 16.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain UPF0029 PF01205.19 CCM01924.1 - 9.4e-23 80.6 0.0 1.6e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 ATP_transf PF09830.9 CCM01925.1 - 8.9e-20 70.6 0.0 1.4e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4922 PF16269.5 CCM01925.1 - 0.0063 16.3 0.0 3.9 7.2 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4922) DUF4690 PF15756.5 CCM01927.1 - 0.00014 22.4 0.4 0.00063 20.3 0.4 2.1 1 0 0 1 1 1 1 Small Novel Rich in Cartilage Amnionless PF14828.6 CCM01927.1 - 0.07 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Amnionless CENP-U PF13097.6 CCM01928.1 - 2.7 7.9 11.3 5.9 6.8 11.3 1.5 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit DNA_pol_phi PF04931.13 CCM01928.1 - 4.4 5.3 15.6 8.1 4.4 15.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi HicA_toxin PF07927.12 CCM01929.1 - 2.3e-08 34.0 0.0 2.8e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 HicA toxin of bacterial toxin-antitoxin, DUF1577 PF07614.11 CCM01929.1 - 0.26 10.4 0.0 0.26 10.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) RabGAP-TBC PF00566.18 CCM01930.1 - 2.3e-53 181.1 0.0 3e-53 180.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain NUP50 PF08911.11 CCM01931.1 - 4.1e-17 62.6 1.9 4.1e-17 62.6 1.9 7.0 5 3 0 5 5 5 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.18 CCM01931.1 - 1.1e-11 45.1 0.2 2.1e-11 44.1 0.2 1.4 1 0 0 1 1 1 1 RanBP1 domain Ferritin_2 PF13668.6 CCM01932.1 - 1.4e-17 64.1 0.8 2.3e-17 63.5 0.8 1.2 1 0 0 1 1 1 1 Ferritin-like domain Pectate_lyase_3 PF12708.7 CCM01933.1 - 1.5e-80 270.1 27.1 3.3e-72 242.8 9.3 3.6 3 1 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CCM01933.1 - 5.8e-05 22.7 2.4 0.032 13.9 0.4 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase AA_permease PF00324.21 CCM01935.1 - 2e-124 415.8 37.0 2.8e-124 415.4 37.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCM01935.1 - 4.7e-33 114.7 41.8 6.9e-33 114.1 41.8 1.2 1 0 0 1 1 1 1 Amino acid permease LRR_8 PF13855.6 CCM01935.1 - 6e-05 22.7 4.6 0.00041 20.1 0.5 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CCM01935.1 - 0.00078 19.8 3.6 0.026 15.0 0.2 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCM01935.1 - 0.19 12.4 2.9 10 7.1 0.2 4.0 3 0 0 3 3 3 0 Leucine Rich Repeat RhoGEF PF00621.20 CCM01936.1 - 2.4e-42 145.2 0.0 3.7e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain Mito_carr PF00153.27 CCM01937.1 - 1.5e-58 194.7 3.4 1.4e-19 69.8 0.1 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCM01937.1 - 2.3 7.3 6.4 0.29 10.3 0.2 2.5 3 1 1 4 4 4 0 Gammaproteobacterial serine protease PX PF00787.24 CCM01938.1 - 1.5e-17 63.6 0.0 2.5e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 PX domain DUF772 PF05598.11 CCM01938.1 - 0.012 15.6 0.1 0.43 10.6 0.0 2.5 2 0 0 2 2 2 0 Transposase domain (DUF772) CBS PF00571.28 CCM01939.1 - 3.2e-26 91.5 1.3 2.6e-10 40.6 0.0 4.5 4 0 0 4 4 4 4 CBS domain SPRY PF00622.28 CCM01940.1 - 3.8e-20 72.2 0.0 6.2e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 SPRY domain OATP PF03137.20 CCM01941.1 - 0.0062 14.9 0.0 0.0071 14.7 0.0 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family TMEM61 PF15105.6 CCM01941.1 - 0.014 15.3 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 TMEM61 protein family MFS_2 PF13347.6 CCM01941.1 - 0.035 12.7 0.0 0.038 12.5 0.0 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein G0-G1_switch_2 PF15103.6 CCM01941.1 - 0.044 14.2 0.3 0.073 13.5 0.3 1.3 1 1 0 1 1 1 0 G0/G1 switch protein 2 Saf_2TM PF18303.1 CCM01941.1 - 0.06 12.9 0.0 0.071 12.7 0.0 1.1 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4381 PF14316.6 CCM01941.1 - 0.093 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF3357 PF11837.8 CCM01941.1 - 0.15 12.6 0.0 0.19 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) tRNA-synt_2 PF00152.20 CCM01942.1 - 1.3e-80 270.8 0.1 1.9e-80 270.3 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCM01942.1 - 1.1e-08 35.0 0.0 1.9e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CCM01942.1 - 0.0042 16.6 2.2 1.3 8.5 0.0 3.3 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) Erythro_esteras PF05139.14 CCM01942.1 - 0.66 9.7 5.1 1.9 8.2 0.0 3.1 3 1 1 4 4 4 0 Erythromycin esterase Aminotran_1_2 PF00155.21 CCM01943.1 - 4.2e-89 299.3 0.0 4.7e-89 299.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Elong_Iki1 PF10483.9 CCM01945.1 - 3.8e-09 36.5 0.1 0.00075 19.1 0.0 2.7 2 1 0 2 2 2 2 Elongator subunit Iki1 Abhydrolase_1 PF00561.20 CCM01946.1 - 2.2e-17 63.6 0.0 2.8e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM01946.1 - 1.6e-12 47.2 0.0 2.2e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM01946.1 - 7.5e-12 46.3 0.8 9.1e-12 46.0 0.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CCM01946.1 - 0.0012 18.5 0.2 0.024 14.2 0.2 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CCM01946.1 - 0.041 13.7 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 CCM01946.1 - 0.07 13.0 0.1 0.097 12.5 0.1 1.2 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.7 CCM01946.1 - 0.097 12.4 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Acetyltransf_1 PF00583.25 CCM01947.1 - 0.00076 19.7 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CCM01947.1 - 0.042 13.5 0.0 0.42 10.3 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DLH PF01738.18 CCM01948.1 - 2.3e-17 63.3 0.0 3.1e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family LIDHydrolase PF10230.9 CCM01948.1 - 0.011 15.3 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF2048 PF09752.9 CCM01948.1 - 0.15 11.1 0.0 0.46 9.5 0.0 1.7 2 0 0 2 2 2 0 Abhydrolase domain containing 18 GTP_EFTU PF00009.27 CCM01949.1 - 3.8e-54 183.2 0.1 6.2e-54 182.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCM01949.1 - 3.3e-41 140.1 0.0 6.3e-41 139.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain Pkinase PF00069.25 CCM01949.1 - 5.9e-36 124.2 0.0 1.3e-33 116.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM01949.1 - 3.7e-15 55.9 0.0 6.4e-14 51.9 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase GTP_EFTU_D2 PF03144.25 CCM01949.1 - 7e-15 55.2 1.6 2.1e-14 53.7 1.6 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Kinase-like PF14531.6 CCM01949.1 - 3.9e-05 23.1 0.0 7.5e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like MMR_HSR1 PF01926.23 CCM01949.1 - 0.0051 16.9 0.1 0.072 13.2 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Kdo PF06293.14 CCM01949.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM01949.1 - 0.05 13.5 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family GTP_EFTU_D4 PF14578.6 CCM01949.1 - 1.2 9.1 3.6 0.76 9.7 1.1 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Ribosomal_L32e PF01655.18 CCM01950.1 - 3.8e-51 172.0 1.1 4.4e-51 171.8 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Memo PF01875.17 CCM01951.1 - 6e-73 245.3 0.0 6.9e-73 245.1 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein HABP4_PAI-RBP1 PF04774.15 CCM01952.1 - 6.7e-14 52.7 8.5 6.7e-14 52.7 8.5 2.4 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family PHD PF00628.29 CCM01953.1 - 9.6e-10 38.2 8.6 9.6e-10 38.2 8.6 2.2 2 0 0 2 2 2 1 PHD-finger zf-CpG_bind_C PF12269.8 CCM01953.1 - 0.00018 21.4 0.5 0.00018 21.4 0.5 2.2 2 0 0 2 2 2 1 CpG binding protein zinc finger C terminal domain Takusan PF04822.13 CCM01953.1 - 1.2 9.1 5.6 0.13 12.1 0.4 2.0 2 0 0 2 2 2 0 Takusan PHD_4 PF16866.5 CCM01953.1 - 2.5 8.3 6.4 6.2 7.0 6.4 1.7 1 0 0 1 1 1 0 PHD-finger LSM PF01423.22 CCM01954.1 - 3.8e-15 55.3 0.2 5.2e-15 54.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CCM01954.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Hfq protein ETC_C1_NDUFA5 PF04716.14 CCM01955.1 - 1.7e-24 85.4 0.3 2.7e-24 84.7 0.3 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region Thiolase_N PF00108.23 CCM01956.1 - 9e-64 215.3 0.4 1.5e-63 214.6 0.4 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCM01956.1 - 1.1e-40 138.1 0.3 3e-40 136.7 0.3 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 CCM01956.1 - 0.12 12.5 0.0 0.45 10.7 0.0 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Ribosomal_S3_C PF00189.20 CCM01957.1 - 8.8e-24 83.8 0.1 2.8e-23 82.2 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CCM01957.1 - 8.7e-12 44.7 0.0 1.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 CCM01957.1 - 0.031 14.8 0.0 0.06 13.8 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 COX2-transmemb PF09125.10 CCM01958.1 - 0.068 13.0 3.6 0.21 11.4 3.6 1.9 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane Ribophorin_II PF05817.14 CCM01958.1 - 1.1 7.8 3.6 1.5 7.3 3.6 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II Wzy_C PF04932.15 CCM01958.1 - 5.7 6.5 9.4 0.68 9.6 1.9 2.2 2 0 0 2 2 2 0 O-Antigen ligase Mpp10 PF04006.12 CCM01959.1 - 1.8e-120 403.3 51.0 4.8e-120 401.9 48.2 2.0 2 0 0 2 2 2 2 Mpp10 protein Metal_resist PF13801.6 CCM01959.1 - 2.4 8.4 9.7 1.4 9.1 0.7 3.1 3 0 0 3 3 3 0 Heavy-metal resistance V-SNARE_C PF12352.8 CCM01960.1 - 0.0011 19.2 6.0 0.34 11.2 0.8 2.8 3 0 0 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus Phage_Gp23 PF10669.9 CCM01960.1 - 0.05 13.9 1.2 0.05 13.9 1.2 2.2 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) XhlA PF10779.9 CCM01960.1 - 3.2 8.0 10.7 5.5 7.3 0.1 3.8 3 1 1 4 4 4 0 Haemolysin XhlA DUF948 PF06103.11 CCM01960.1 - 6.9 7.0 5.7 10 6.5 0.8 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SAD_SRA PF02182.17 CCM01961.1 - 1.5e-41 141.7 0.0 2.4e-41 141.0 0.0 1.4 1 0 0 1 1 1 1 SAD/SRA domain MPDZ_u10 PF16667.5 CCM01962.1 - 0.47 11.4 6.1 0.86 10.5 6.1 1.4 1 0 0 1 1 1 0 Unstructured region 10 on multiple PDZ protein 7TM_GPCR_Sru PF10322.9 CCM01964.1 - 0.063 12.6 0.7 0.076 12.3 0.7 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sru UPF0160 PF03690.13 CCM01965.1 - 3.3e-126 421.2 0.0 4.3e-126 420.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) MARVEL PF01284.23 CCM01965.1 - 0.00053 20.0 2.8 0.0012 18.9 2.8 1.5 1 1 0 1 1 1 1 Membrane-associating domain Lipase_3 PF01764.25 CCM01966.1 - 6.9e-13 48.7 0.0 4.3e-12 46.1 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.20 CCM01966.1 - 0.00098 18.8 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM01966.1 - 0.0034 16.7 0.0 0.0057 15.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM01966.1 - 0.0062 17.2 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CCM01966.1 - 0.018 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 CCM01966.1 - 0.059 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative esterase MFS_1 PF07690.16 CCM01967.1 - 1.6e-20 73.3 21.3 1.6e-20 73.3 21.3 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CCM01967.1 - 0.055 11.7 0.9 0.096 11.0 0.0 1.7 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 CCM01967.1 - 0.63 8.8 13.0 6.8 5.4 13.0 2.8 1 1 0 1 1 1 0 Sugar (and other) transporter Ribosomal_L15e PF00827.17 CCM01968.1 - 5.1e-90 300.3 12.2 6.1e-90 300.1 12.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 SurE PF01975.17 CCM01970.1 - 1.6e-12 47.7 0.0 2.1e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE RasGEF PF00617.19 CCM01971.1 - 2.6e-34 119.0 0.1 5.6e-34 117.9 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain Ras PF00071.22 CCM01971.1 - 3.8e-07 29.9 0.0 2.1e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 Ras family RasGEF_N PF00618.20 CCM01971.1 - 1.5e-05 25.2 0.4 0.00012 22.3 0.4 2.3 1 1 0 1 1 1 1 RasGEF N-terminal motif IL28A PF15177.6 CCM01971.1 - 0.063 13.1 0.2 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 Interleukin-28A ABC_tran PF00005.27 CCM01971.1 - 0.11 13.1 0.0 0.33 11.5 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CCM01971.1 - 0.19 12.0 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 CCM01972.1 - 1.9e-46 158.0 0.0 3.2e-45 154.0 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM01972.1 - 1.5e-29 102.5 0.0 2.1e-28 98.9 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ANAPC4 PF12896.7 CCM01973.1 - 1.8e-43 148.5 0.0 2.7e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 CCM01973.1 - 1.9e-07 31.2 0.0 4.1e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CCM01973.1 - 0.061 13.3 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat bZIP_1 PF00170.21 CCM01974.1 - 0.00038 20.5 8.2 0.0012 18.9 8.2 1.8 1 0 0 1 1 1 1 bZIP transcription factor SlyX PF04102.12 CCM01974.1 - 0.00093 19.8 1.7 0.0028 18.3 1.7 1.8 1 0 0 1 1 1 1 SlyX BST2 PF16716.5 CCM01974.1 - 0.002 18.7 5.3 0.0034 17.9 5.3 1.3 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 ATG16 PF08614.11 CCM01974.1 - 0.0031 17.8 3.6 0.0074 16.5 3.6 1.6 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) IKBKB_SDD PF18397.1 CCM01974.1 - 0.0037 16.6 2.2 0.0058 16.0 2.2 1.2 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain ZapB PF06005.12 CCM01974.1 - 0.011 16.2 3.3 0.019 15.4 3.3 1.3 1 0 0 1 1 1 0 Cell division protein ZapB YabA PF06156.13 CCM01974.1 - 0.029 15.0 0.7 0.052 14.2 0.7 1.3 1 0 0 1 1 1 0 Initiation control protein YabA APG6_N PF17675.1 CCM01974.1 - 0.03 14.9 4.6 0.05 14.1 4.6 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region THOC7 PF05615.13 CCM01974.1 - 0.037 14.3 5.8 0.066 13.5 5.8 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 MAD PF05557.13 CCM01974.1 - 0.041 12.3 2.4 0.055 11.8 2.4 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein Cnn_1N PF07989.11 CCM01974.1 - 0.051 13.7 1.3 0.1 12.7 1.3 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 UPF0242 PF06785.11 CCM01974.1 - 0.065 13.3 2.2 0.097 12.8 2.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TolA_bind_tri PF16331.5 CCM01974.1 - 0.068 13.3 3.3 0.13 12.4 3.3 1.4 1 0 0 1 1 1 0 TolA binding protein trimerisation betaPIX_CC PF16523.5 CCM01974.1 - 0.077 12.8 0.5 0.14 12.0 0.5 1.3 1 0 0 1 1 1 0 betaPIX coiled coil GIT_CC PF16559.5 CCM01974.1 - 0.093 12.6 1.1 0.17 11.7 1.1 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor GrpE PF01025.19 CCM01974.1 - 0.1 12.3 0.3 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 GrpE Fib_alpha PF08702.10 CCM01974.1 - 0.1 12.8 1.5 0.18 12.0 1.5 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 CCM01974.1 - 0.11 12.9 1.1 0.19 12.2 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 bZIP_2 PF07716.15 CCM01974.1 - 0.36 11.0 19.6 0.1 12.7 1.8 2.9 2 1 1 3 3 3 0 Basic region leucine zipper Atg14 PF10186.9 CCM01974.1 - 0.37 9.8 4.8 0.91 8.5 4.9 1.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF148 PF02520.17 CCM01974.1 - 0.69 10.0 3.0 1.2 9.3 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 Ax_dynein_light PF10211.9 CCM01974.1 - 0.83 9.6 5.8 1.3 9.0 5.8 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain DivIC PF04977.15 CCM01974.1 - 2.1 8.2 5.7 4.3 7.2 4.8 1.9 1 1 1 2 2 2 0 Septum formation initiator AAA_13 PF13166.6 CCM01974.1 - 2.4 6.7 4.4 3.4 6.2 4.4 1.1 1 0 0 1 1 1 0 AAA domain DUF4164 PF13747.6 CCM01974.1 - 2.7 8.3 9.0 0.17 12.2 3.6 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4164) GPI2 PF06432.11 CCM01975.1 - 6.6e-84 281.7 13.8 7.5e-84 281.5 13.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase DUF2417 PF10329.9 CCM01975.1 - 0.39 10.1 5.8 5.1 6.4 0.8 2.5 2 1 0 2 2 2 0 Region of unknown function (DUF2417) Actin PF00022.19 CCM01977.1 - 1.4e-129 432.3 0.0 6.2e-129 430.2 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CCM01977.1 - 0.064 12.1 0.0 0.47 9.2 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein Ribosomal_S24e PF01282.19 CCM01978.1 - 4.2e-33 113.1 0.2 7.5e-33 112.3 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e Vel1p PF10339.9 CCM01980.1 - 0.011 15.2 0.2 0.018 14.5 0.2 1.3 1 0 0 1 1 1 0 Yeast-specific zinc responsive HEAT PF02985.22 CCM01981.1 - 2e-44 145.8 12.4 0.0044 17.2 0.1 13.6 14 0 0 14 14 14 10 HEAT repeat HEAT_2 PF13646.6 CCM01981.1 - 2.4e-35 120.8 10.5 3.3e-11 43.4 0.0 7.0 3 3 3 6 6 6 6 HEAT repeats Vac14_Fab1_bd PF12755.7 CCM01981.1 - 2.3e-11 44.1 0.2 0.0013 19.3 0.0 6.3 3 2 5 8 8 8 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CCM01981.1 - 1.9e-09 37.8 4.7 0.01 15.9 0.1 5.3 3 3 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CCM01981.1 - 2.7e-08 34.1 11.7 0.12 12.9 0.0 9.2 7 4 4 11 11 11 2 HEAT-like repeat Arm PF00514.23 CCM01981.1 - 3.7e-06 26.8 2.3 4.1 7.6 0.0 6.2 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 CCM01981.1 - 1.6e-05 23.7 2.5 0.016 13.8 1.3 3.3 3 1 1 4 4 4 2 Adaptin N terminal region TAF6_C PF07571.13 CCM01981.1 - 2.7e-05 24.4 0.2 0.011 16.0 0.0 4.2 5 1 0 5 5 5 1 TAF6 C-terminal HEAT repeat domain Tugs PF17840.1 CCM01981.1 - 0.0079 16.4 1.3 0.022 14.9 0.5 2.3 2 0 0 2 2 2 1 Tethering Ubl4a to BAGS domain IFRD PF05004.13 CCM01981.1 - 0.023 13.8 0.8 0.6 9.2 0.2 3.2 3 1 0 3 3 3 0 Interferon-related developmental regulator (IFRD) Ecm29 PF13001.7 CCM01981.1 - 0.051 12.2 2.7 19 3.8 0.2 4.4 4 1 1 5 5 5 0 Proteasome stabiliser HEAT_PBS PF03130.16 CCM01981.1 - 1.5 9.7 6.0 4.7 8.2 0.1 5.1 6 0 0 6 6 4 0 PBS lyase HEAT-like repeat Aldose_epim PF01263.20 CCM01982.1 - 3.1e-29 102.2 0.0 3.5e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase TAL_FSA PF00923.19 CCM01983.1 - 1.9e-13 50.4 0.0 2.8e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase PIG-F PF06699.11 CCM01984.1 - 1.6e-23 83.8 3.8 8.8e-23 81.4 3.1 2.1 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F Hydrolase_6 PF13344.6 CCM01985.1 - 1.8e-30 105.0 0.0 2.9e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM01985.1 - 4.5e-18 65.1 0.0 8.9e-18 64.1 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CCM01985.1 - 3.3e-12 47.2 0.0 4.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCM01985.1 - 2.5e-10 40.7 0.1 4.2e-05 23.7 0.0 2.4 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HTHP PF11534.8 CCM01985.1 - 0.019 15.4 0.0 0.045 14.2 0.0 1.6 1 0 0 1 1 1 0 Hexameric tyrosine-coordinated heme protein (HTHP) PGP_phosphatase PF09419.10 CCM01985.1 - 0.028 14.0 0.0 0.081 12.5 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Ribosomal_L7Ae PF01248.26 CCM01985.1 - 0.09 12.5 0.1 0.25 11.1 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L34e PF01199.18 CCM01986.1 - 1.1e-41 141.0 3.8 1.6e-41 140.5 3.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e Ribosomal_L31e PF01198.19 CCM01987.1 - 9.7e-40 134.7 0.5 1.8e-39 133.9 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L31e Tetraspanin PF00335.20 CCM01987.1 - 2.1 8.0 6.0 4.1 7.1 6.1 1.4 1 1 0 1 1 1 0 Tetraspanin family CAP59_mtransfer PF11735.8 CCM01988.1 - 3.1e-69 233.3 0.0 3.7e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 VIT1 PF01988.19 CCM01991.1 - 2.9e-62 210.3 7.3 3.4e-62 210.1 7.3 1.1 1 0 0 1 1 1 1 VIT family SLATT_fungal PF18142.1 CCM01991.1 - 0.56 10.2 0.0 0.56 10.2 0.0 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain Glyco_transf_90 PF05686.12 CCM01992.1 - 7.7e-14 51.4 0.6 1.1e-12 47.5 0.4 2.8 3 1 0 3 3 3 1 Glycosyl transferase family 90 N2227 PF07942.12 CCM01993.1 - 1.2e-75 254.2 0.2 1e-62 211.8 0.0 2.1 2 0 0 2 2 2 2 N2227-like protein Methyltransf_23 PF13489.6 CCM01993.1 - 0.0026 17.6 0.0 0.017 15.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM01993.1 - 0.0072 17.1 0.0 0.025 15.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM01993.1 - 0.041 14.5 0.0 0.11 13.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF4628 PF15429.6 CCM01994.1 - 0.088 12.5 0.1 0.092 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) JAB PF01398.21 CCM01996.1 - 5e-16 58.7 0.0 8.2e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 CCM01996.1 - 6e-07 29.2 0.0 1.4e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF4329 PF14220.6 CCM01996.1 - 0.036 14.1 0.0 0.15 12.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4329) Lamp PF01299.17 CCM01996.1 - 0.067 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Molybdopterin PF00384.22 CCM01997.1 - 3.5e-63 214.1 0.0 4.1e-61 207.2 0.0 2.9 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 CCM01997.1 - 3.4e-20 71.9 0.6 1.2e-19 70.2 0.4 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 CCM01997.1 - 1.7e-17 62.7 0.2 1.7e-17 62.7 0.2 2.3 3 0 0 3 3 3 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 CCM01997.1 - 3.3e-17 62.9 0.4 8.2e-17 61.6 0.4 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 CCM01997.1 - 1.6e-08 34.3 0.6 1.6e-08 34.3 0.6 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.27 CCM01997.1 - 0.098 12.5 1.1 4.8 7.2 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain TPP_enzyme_M PF00205.22 CCM01997.1 - 0.12 12.1 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Adeno_PIX PF03955.14 CCM01997.1 - 1 9.5 4.0 0.8 9.9 0.3 2.5 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) DUF4961 PF16328.5 CCM01998.1 - 0.032 13.5 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4961) Sugar_tr PF00083.24 CCM01999.1 - 5.2e-97 325.5 21.3 6.7e-97 325.2 21.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM01999.1 - 2.4e-27 95.8 28.1 3.6e-27 95.2 28.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM01999.1 - 3.9e-05 22.3 3.0 3.9e-05 22.3 3.0 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CCM01999.1 - 0.026 12.9 5.7 0.06 11.7 2.2 2.3 2 1 0 2 2 2 0 Transmembrane secretion effector ABC_membrane PF00664.23 CCM02000.1 - 2.6e-81 273.3 23.4 3.9e-44 151.3 6.9 2.4 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCM02000.1 - 3.2e-63 212.3 0.0 1.3e-30 106.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCM02000.1 - 2.5e-17 63.1 7.3 7.9e-07 28.7 1.0 4.4 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CCM02000.1 - 6.2e-09 36.5 3.6 0.0001 22.7 0.1 4.1 4 1 0 4 4 2 2 AAA ATPase domain AAA_22 PF13401.6 CCM02000.1 - 2.8e-08 34.1 0.4 0.05 13.9 0.1 4.4 3 2 0 3 3 2 2 AAA domain ABC_ATPase PF09818.9 CCM02000.1 - 1.7e-07 30.4 0.6 0.0028 16.5 0.1 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class IstB_IS21 PF01695.17 CCM02000.1 - 5.8e-07 29.4 0.1 3.1 7.5 0.0 4.4 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_29 PF13555.6 CCM02000.1 - 7.1e-07 28.9 0.2 0.029 14.1 0.1 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 CCM02000.1 - 4.6e-06 26.9 0.3 0.01 16.0 0.0 2.5 2 0 0 2 2 2 2 Helicase HerA, central domain RsgA_GTPase PF03193.16 CCM02000.1 - 5.5e-06 26.4 0.0 0.096 12.6 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 CCM02000.1 - 8e-06 25.3 0.0 0.13 11.5 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_21 PF13304.6 CCM02000.1 - 1.4e-05 25.0 0.5 11 5.7 0.1 4.3 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 CCM02000.1 - 1.5e-05 25.5 0.0 0.22 12.1 0.0 3.0 3 1 0 3 3 2 2 AAA domain AAA_15 PF13175.6 CCM02000.1 - 1.6e-05 24.8 0.0 0.0032 17.2 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CCM02000.1 - 2.9e-05 23.9 0.3 0.34 10.6 0.1 3.2 3 1 0 3 3 2 2 AAA domain AAA_33 PF13671.6 CCM02000.1 - 0.0001 22.5 0.0 0.33 11.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CCM02000.1 - 0.00026 21.0 0.1 1.9 8.5 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) G-alpha PF00503.20 CCM02000.1 - 0.00038 19.7 0.0 0.43 9.7 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit APS_kinase PF01583.20 CCM02000.1 - 0.0013 18.7 0.0 1.9 8.4 0.0 2.6 2 0 0 2 2 2 2 Adenylylsulphate kinase Sigma54_activ_2 PF14532.6 CCM02000.1 - 0.0018 18.4 0.0 6.5 6.9 0.0 3.7 4 0 0 4 4 3 0 Sigma-54 interaction domain PRK PF00485.18 CCM02000.1 - 0.002 17.9 0.0 0.37 10.5 0.0 2.5 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family DUF2075 PF09848.9 CCM02000.1 - 0.003 16.8 0.1 0.65 9.2 0.0 2.8 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 CCM02000.1 - 0.0076 16.8 0.9 0.83 10.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 CCM02000.1 - 0.0082 15.7 0.0 8 5.9 0.0 3.1 3 0 0 3 3 3 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 CCM02000.1 - 0.0098 15.3 0.0 5 6.4 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CCM02000.1 - 0.012 15.9 1.5 7.6 6.8 0.0 3.4 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.6 CCM02000.1 - 0.012 15.1 0.1 9.9 5.7 0.0 3.9 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 CCM02000.1 - 0.013 15.9 0.0 5.9 7.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Thymidylate_kin PF02223.17 CCM02000.1 - 0.016 14.9 0.1 1.5 8.4 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase AAA_14 PF13173.6 CCM02000.1 - 0.016 15.3 0.0 1.6 8.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain Rop-like PF05082.13 CCM02000.1 - 0.018 14.9 0.0 0.61 9.9 0.0 2.5 2 0 0 2 2 2 0 Rop-like AAA_24 PF13479.6 CCM02000.1 - 0.022 14.5 0.0 2.8 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CCM02000.1 - 0.024 14.3 0.0 8.2 6.1 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain SbcCD_C PF13558.6 CCM02000.1 - 0.028 14.6 2.9 9.8 6.5 0.2 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 CCM02000.1 - 0.04 13.1 0.1 10 5.2 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain MMR_HSR1 PF01926.23 CCM02000.1 - 0.041 14.0 0.0 14 5.8 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 CCM02000.1 - 0.057 12.8 0.0 12 5.1 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_19 PF13245.6 CCM02000.1 - 0.061 13.7 0.3 7.1 7.0 0.0 3.2 2 1 0 2 2 2 0 AAA domain CbiA PF01656.23 CCM02000.1 - 0.063 13.3 0.0 8.6 6.4 0.0 2.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.12 CCM02000.1 - 0.064 13.2 0.5 19 5.1 0.0 2.9 3 0 0 3 3 2 0 NACHT domain Ploopntkinase3 PF18751.1 CCM02000.1 - 0.075 12.9 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 DUF3987 PF13148.6 CCM02000.1 - 0.083 11.9 0.3 6.7 5.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) PhoH PF02562.16 CCM02000.1 - 0.14 11.6 0.6 12 5.2 0.0 3.3 4 0 0 4 4 3 0 PhoH-like protein CoaE PF01121.20 CCM02000.1 - 0.14 11.8 2.6 11 5.6 0.1 2.8 3 0 0 3 3 2 0 Dephospho-CoA kinase AAA_17 PF13207.6 CCM02000.1 - 0.14 12.6 2.1 11 6.5 0.3 2.6 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 CCM02000.1 - 0.16 11.8 1.4 13 5.6 0.1 3.1 3 0 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein Rad17 PF03215.15 CCM02000.1 - 0.17 11.8 0.0 5.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain Cytidylate_kin PF02224.18 CCM02000.1 - 0.2 11.4 2.7 8.4 6.1 0.0 3.3 3 0 0 3 3 3 0 Cytidylate kinase Glyco_hydro_127 PF07944.12 CCM02001.1 - 2.2e-25 89.2 5.8 4.6e-25 88.1 5.8 1.5 1 1 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 adh_short_C2 PF13561.6 CCM02002.1 - 3.2e-58 197.1 2.8 4.3e-58 196.6 2.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM02002.1 - 3.9e-50 170.0 5.8 5.4e-50 169.6 5.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM02002.1 - 1.6e-17 64.0 0.8 2.3e-17 63.5 0.8 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM02002.1 - 8.8e-09 35.2 0.5 1.3e-08 34.6 0.5 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM02002.1 - 7e-05 22.4 0.1 9.2e-05 22.0 0.1 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CCM02002.1 - 0.027 13.6 0.6 0.054 12.6 0.4 1.5 1 1 0 1 1 1 0 RmlD substrate binding domain THF_DHG_CYH_C PF02882.19 CCM02002.1 - 0.052 12.9 0.1 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ABC2_membrane PF01061.24 CCM02003.1 - 1.9e-73 246.4 52.4 1.3e-41 142.3 15.2 3.1 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 CCM02003.1 - 7.2e-38 130.2 0.0 1.3e-17 64.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCM02003.1 - 1.1e-37 127.7 11.7 1e-30 105.4 0.1 3.0 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CCM02003.1 - 7e-17 61.8 0.1 2.4e-16 60.1 0.1 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 CCM02003.1 - 7.6e-06 25.9 0.0 0.00028 20.8 0.1 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CCM02003.1 - 1.7e-05 25.3 0.1 0.016 15.6 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCM02003.1 - 5.6e-05 23.4 0.0 0.28 11.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 CCM02003.1 - 0.00014 22.5 0.0 0.38 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCM02003.1 - 0.00049 19.7 0.1 0.056 13.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCM02003.1 - 0.0029 17.7 0.1 0.79 9.8 0.3 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_17 PF13207.6 CCM02003.1 - 0.0051 17.2 0.0 0.8 10.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CCM02003.1 - 0.0052 16.4 0.4 3 7.4 0.6 2.9 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CCM02003.1 - 0.0085 15.8 0.6 0.23 11.3 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CCM02003.1 - 0.0086 15.8 0.2 2.4 7.8 0.5 2.5 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 CCM02003.1 - 0.012 15.3 0.1 3.9 7.2 0.2 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 CCM02003.1 - 0.02 15.1 0.1 7.8 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCM02003.1 - 0.029 14.3 0.1 1.6 8.6 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_21 PF13304.6 CCM02003.1 - 0.033 14.0 0.1 15 5.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 CCM02003.1 - 0.046 14.0 0.3 4.5 7.5 0.2 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CCM02003.1 - 0.1 13.0 0.1 25 5.3 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 CCM02003.1 - 0.11 11.9 0.0 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CCM02003.1 - 0.12 11.7 0.0 2.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.15 CCM02003.1 - 0.12 12.2 0.0 17 5.2 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_23 PF13476.6 CCM02003.1 - 0.15 12.5 0.1 0.34 11.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCM02003.1 - 0.16 12.0 0.2 3.6 7.6 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC2_membrane_3 PF12698.7 CCM02003.1 - 0.41 9.7 51.0 0.023 13.8 26.1 2.9 2 2 0 2 2 2 0 ABC-2 family transporter protein TBCC PF07986.12 CCM02004.1 - 7.5e-23 80.5 0.1 1.4e-22 79.7 0.1 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 CCM02004.1 - 3e-09 37.3 0.6 4.5e-09 36.8 0.6 1.2 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain zf-rbx1 PF12678.7 CCM02005.1 - 1.5e-24 86.0 12.8 2.2e-24 85.5 12.8 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCM02005.1 - 1e-16 60.7 9.6 1.3e-16 60.4 9.6 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CCM02005.1 - 2e-06 28.0 14.7 8.2e-05 22.9 14.7 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCM02005.1 - 0.00099 18.9 11.8 0.018 14.9 11.8 2.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM02005.1 - 0.0012 18.7 14.7 0.0012 18.6 8.8 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM02005.1 - 0.18 11.7 10.3 0.71 9.8 4.2 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM02005.1 - 0.32 11.1 7.7 1.1 9.3 7.7 2.0 1 1 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CCM02005.1 - 0.41 10.3 14.6 59 3.4 14.6 2.2 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 CCM02005.1 - 0.49 10.6 9.6 2.7 8.2 9.8 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_11 PF17123.5 CCM02005.1 - 0.79 9.5 16.6 51 3.7 16.6 2.4 1 1 0 1 1 1 0 RING-like zinc finger SURF6 PF04935.12 CCM02006.1 - 1.2e-46 159.0 43.2 1.2e-46 159.0 43.2 3.2 3 1 1 4 4 4 1 Surfeit locus protein 6 RRP14 PF15459.6 CCM02006.1 - 7.4e-07 29.7 6.4 7.4e-07 29.7 6.4 5.7 5 1 0 5 5 5 1 60S ribosome biogenesis protein Rrp14 Cation_efflux PF01545.21 CCM02007.1 - 0.00017 21.4 4.3 0.00033 20.4 4.3 1.7 1 1 0 1 1 1 1 Cation efflux family PTPA PF03095.15 CCM02008.1 - 9.1e-128 425.9 0.0 1.1e-127 425.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Cu-oxidase_2 PF07731.14 CCM02009.1 - 1.7e-36 125.0 9.7 7.4e-35 119.7 0.7 3.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CCM02009.1 - 5e-35 121.0 1.1 6.7e-35 120.6 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCM02009.1 - 1.2e-34 118.8 7.1 1.5e-31 108.9 0.8 3.5 3 0 0 3 3 3 2 Multicopper oxidase RskA PF10099.9 CCM02009.1 - 0.0005 20.4 0.1 0.00091 19.6 0.1 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Phosphoesterase PF04185.14 CCM02010.1 - 1.9e-27 96.4 3.6 1.6e-26 93.3 3.5 2.0 1 1 0 1 1 1 1 Phosphoesterase family F-box PF00646.33 CCM02013.1 - 0.00015 21.5 0.4 0.00041 20.1 0.4 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCM02013.1 - 0.00022 21.0 0.8 0.00067 19.5 0.8 1.8 1 0 0 1 1 1 1 F-box-like p450 PF00067.22 CCM02014.1 - 1.3e-62 212.1 0.0 2.7e-62 211.0 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 CREPT PF16566.5 CCM02015.1 - 0.0022 18.2 2.4 1.1 9.5 0.0 3.1 3 0 0 3 3 3 1 Cell-cycle alteration and expression-elevated protein in tumour APG6_N PF17675.1 CCM02015.1 - 0.0022 18.5 1.4 0.11 13.0 0.0 2.8 2 1 1 3 3 3 1 Apg6 coiled-coil region AAA_13 PF13166.6 CCM02015.1 - 0.0041 15.8 2.6 0.0057 15.4 2.6 1.1 1 0 0 1 1 1 1 AAA domain GAS PF13851.6 CCM02015.1 - 0.005 16.2 0.9 1.2 8.5 0.0 2.9 3 0 0 3 3 3 1 Growth-arrest specific micro-tubule binding T3SSipB PF16535.5 CCM02015.1 - 0.0053 17.2 14.6 0.012 16.1 0.1 3.6 2 1 1 3 3 3 2 Type III cell invasion protein SipB Fez1 PF06818.15 CCM02015.1 - 0.024 15.1 3.9 4.7 7.6 0.0 2.6 2 1 0 2 2 2 0 Fez1 Bacillus_HBL PF05791.11 CCM02015.1 - 0.024 14.5 0.8 0.24 11.2 0.0 2.5 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF4201 PF13870.6 CCM02015.1 - 0.025 14.3 5.2 0.19 11.4 0.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) Mod_r PF07200.13 CCM02015.1 - 0.045 13.9 4.1 3.1 7.9 0.8 3.4 4 0 0 4 4 3 0 Modifier of rudimentary (Mod(r)) protein Tmemb_cc2 PF10267.9 CCM02015.1 - 0.051 12.7 5.7 2.4 7.2 0.1 2.2 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Mer2 PF09074.10 CCM02015.1 - 0.064 13.1 1.6 0.43 10.4 0.0 2.3 2 1 0 3 3 3 0 Mer2 TPR_MLP1_2 PF07926.12 CCM02015.1 - 0.087 12.9 7.9 0.48 10.5 0.0 3.5 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein LXG PF04740.12 CCM02015.1 - 0.14 11.8 4.1 0.55 9.9 0.1 2.5 2 0 0 2 2 2 0 LXG domain of WXG superfamily FliJ PF02050.16 CCM02015.1 - 0.15 12.3 7.5 3.4 7.9 0.1 3.5 3 1 0 3 3 3 0 Flagellar FliJ protein Tyrosinase PF00264.20 CCM02015.1 - 0.21 11.9 0.1 0.77 10.0 0.0 1.8 1 1 0 2 2 2 0 Common central domain of tyrosinase She9_MDM33 PF05546.11 CCM02015.1 - 0.37 10.6 3.1 18 5.1 1.1 2.4 2 0 0 2 2 2 0 She9 / Mdm33 family BLOC1S3 PF15753.5 CCM02015.1 - 0.43 10.7 4.8 0.62 10.2 0.1 2.5 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF2524 PF10732.9 CCM02015.1 - 0.67 10.3 3.7 0.49 10.7 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2524) E2R135 PF11570.8 CCM02015.1 - 0.97 9.7 7.3 11 6.3 0.9 3.1 3 1 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF2203 PF09969.9 CCM02015.1 - 1.9 9.2 4.3 29 5.4 0.1 3.2 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) ATP-synt_DE PF00401.20 CCM02015.1 - 1.9 8.8 18.9 3.3 8.1 0.3 3.8 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Cluap1 PF10234.9 CCM02015.1 - 3.6 6.9 7.1 2 7.7 3.3 2.2 1 1 0 2 2 2 0 Clusterin-associated protein-1 Spc7 PF08317.11 CCM02015.1 - 4.2 6.1 7.1 1.7 7.4 0.0 2.8 3 0 0 3 3 3 0 Spc7 kinetochore protein UPF0259 PF06790.11 CCM02016.1 - 0.016 15.0 0.8 0.016 15.0 0.8 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0259) RRF PF01765.19 CCM02016.1 - 0.07 13.1 9.4 1.1 9.2 0.0 3.7 3 0 0 3 3 3 0 Ribosome recycling factor COG2 PF06148.11 CCM02016.1 - 0.095 12.8 3.9 0.47 10.6 0.0 3.0 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 T2SSF PF00482.23 CCM02016.1 - 0.099 12.6 0.2 0.91 9.5 0.0 2.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Apolipoprotein PF01442.18 CCM02016.1 - 0.45 10.4 8.7 1.9 8.3 0.7 3.2 2 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain FTA4 PF13093.6 CCM02016.1 - 1.3 8.9 6.6 2 8.2 3.3 3.0 2 1 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Seryl_tRNA_N PF02403.22 CCM02016.1 - 2.2 8.5 17.6 0.32 11.3 0.4 3.7 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF883 PF05957.13 CCM02016.1 - 2.4 8.8 4.2 23 5.7 0.5 3.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DHR10 PF18595.1 CCM02016.1 - 5.8 7.0 17.4 0.33 11.0 0.5 3.9 4 0 0 4 4 4 0 Designed helical repeat protein 10 domain DivIC PF04977.15 CCM02016.1 - 6 6.7 7.9 26 4.7 0.5 3.3 2 1 0 2 2 2 0 Septum formation initiator SlyX PF04102.12 CCM02016.1 - 7.6 7.2 7.3 2.1 9.0 0.2 3.3 3 0 0 3 3 3 0 SlyX COG2 PF06148.11 CCM02017.1 - 0.006 16.7 4.5 0.23 11.6 0.0 3.3 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Filament PF00038.21 CCM02017.1 - 0.06 12.9 9.4 1.1 8.7 0.2 3.2 3 0 0 3 3 3 0 Intermediate filament protein T2SSF PF00482.23 CCM02017.1 - 0.089 12.7 1.8 0.36 10.8 0.1 2.8 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F She9_MDM33 PF05546.11 CCM02017.1 - 0.36 10.6 3.8 0.65 9.8 0.8 2.5 2 0 0 2 2 2 0 She9 / Mdm33 family GLE1 PF07817.13 CCM02017.1 - 6.7 5.8 13.2 0.63 9.2 1.9 2.9 3 0 0 3 3 3 0 GLE1-like protein DUF745 PF05335.13 CCM02018.1 - 0.0055 16.5 1.6 0.0055 16.5 1.6 3.5 2 1 1 3 3 3 2 Protein of unknown function (DUF745) DUF4600 PF15372.6 CCM02018.1 - 0.11 12.9 4.4 1.5 9.3 1.6 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4600) TMF_DNA_bd PF12329.8 CCM02018.1 - 2.3 8.3 9.4 19 5.3 0.1 4.2 5 0 0 5 5 5 0 TATA element modulatory factor 1 DNA binding ATP-synt_DE PF00401.20 CCM02018.1 - 6.8 7.0 19.3 1 9.7 4.0 4.0 4 0 0 4 4 4 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF2524 PF10732.9 CCM02018.1 - 7.3 7.0 13.1 0.47 10.8 0.4 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2524) DUF4407 PF14362.6 CCM02018.1 - 7.7 5.8 25.5 1.6 8.1 10.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 CCM02018.1 - 9.8 6.5 12.1 2.4 8.4 0.2 3.8 3 1 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain adh_short PF00106.25 CCM02019.1 - 4.2e-41 140.6 0.0 5.4e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM02019.1 - 1e-35 123.4 0.0 1.6e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM02019.1 - 2.6e-13 50.3 0.1 3.8e-13 49.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCM02019.1 - 0.0073 15.5 0.0 0.0094 15.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCM02019.1 - 0.048 13.1 0.0 0.13 11.7 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 CCM02022.1 - 1.6e-05 25.5 0.0 0.00077 20.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain ROQ_II PF18386.1 CCM02022.1 - 0.037 13.8 0.1 0.083 12.7 0.1 1.5 1 0 0 1 1 1 0 Roquin II domain Acetyltransf_3 PF13302.7 CCM02023.1 - 7.2e-08 33.2 0.0 9.1e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM02023.1 - 0.00062 20.0 0.0 0.0016 18.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CCM02023.1 - 0.17 11.8 0.0 8 6.5 0.0 2.2 2 0 0 2 2 2 0 FR47-like protein OPT PF03169.15 CCM02024.1 - 7.2e-127 424.6 49.2 8.2e-127 424.4 49.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DHO_dh PF01180.21 CCM02025.1 - 4.8e-92 308.3 0.0 6e-92 308.0 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 CCM02025.1 - 0.0029 16.7 1.5 0.013 14.6 1.5 1.9 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 CCM02025.1 - 0.041 13.3 0.2 0.092 12.1 0.2 1.5 1 0 0 1 1 1 0 Nitronate monooxygenase Abhydrolase_1 PF00561.20 CCM02026.1 - 9.6e-19 68.0 0.0 3.5e-18 66.2 0.1 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CCM02026.1 - 1e-18 67.4 0.0 1.6e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein WES_acyltransf PF03007.16 CCM02027.1 - 5e-25 88.8 0.0 1e-24 87.7 0.0 1.5 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.13 CCM02027.1 - 4.2e-05 23.5 0.0 0.00016 21.6 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1298) Peptidase_S15 PF02129.18 CCM02027.1 - 0.034 13.8 0.1 0.058 13.0 0.1 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Whi5 PF08528.11 CCM02030.1 - 1.6e-07 30.8 1.7 3.5e-07 29.7 1.7 1.6 1 0 0 1 1 1 1 Whi5 like Aldo_ket_red PF00248.21 CCM02031.1 - 2.7e-60 204.1 0.0 3e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4743 PF15916.5 CCM02032.1 - 1.9e-08 34.3 0.0 4.9e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4743) NUDIX PF00293.28 CCM02032.1 - 0.0052 16.8 0.0 0.018 15.1 0.0 1.9 1 1 0 1 1 1 1 NUDIX domain Aldo_ket_red PF00248.21 CCM02033.1 - 2.2e-69 233.9 0.0 2.7e-69 233.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AsnA PF03590.15 CCM02033.1 - 0.015 15.0 0.2 0.023 14.4 0.2 1.2 1 0 0 1 1 1 0 Aspartate-ammonia ligase GGDEF_2 PF17853.1 CCM02034.1 - 0.075 13.3 0.0 0.23 11.7 0.0 1.7 2 0 0 2 2 2 0 GGDEF-like domain DUF2207 PF09972.9 CCM02035.1 - 0.024 13.4 2.5 0.049 12.4 2.5 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Mod_r PF07200.13 CCM02035.1 - 0.056 13.5 8.2 0.1 12.7 1.9 3.3 3 1 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein CLZ PF16526.5 CCM02035.1 - 0.24 11.8 4.8 0.4 11.1 0.1 3.4 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF2968 PF11180.8 CCM02035.1 - 0.27 10.8 3.9 0.19 11.4 1.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) KASH_CCD PF14662.6 CCM02035.1 - 0.3 10.9 4.8 5.7 6.7 1.0 2.6 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH DivIC PF04977.15 CCM02035.1 - 0.47 10.3 6.2 1.1 9.1 0.7 3.3 3 0 0 3 3 3 0 Septum formation initiator Seryl_tRNA_N PF02403.22 CCM02035.1 - 0.8 10.0 8.9 2.9 8.2 0.9 3.6 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain TBCC_N PF16752.5 CCM02035.1 - 1.3 9.5 5.2 0.5 10.8 1.3 2.3 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain Csm2_III-A PF03750.13 CCM02035.1 - 1.9 9.4 7.5 33 5.3 0.9 3.9 3 1 0 3 3 3 0 Csm2 Type III-A ZapB PF06005.12 CCM02035.1 - 2.5 8.6 12.6 0.16 12.5 0.9 3.4 4 0 0 4 4 4 0 Cell division protein ZapB Cnn_1N PF07989.11 CCM02035.1 - 9.6 6.4 9.7 12 6.2 0.6 3.0 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 TACC_C PF05010.14 CCM02036.1 - 0.0039 17.0 5.1 0.065 13.0 3.9 2.5 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Baculo_PEP_C PF04513.12 CCM02036.1 - 0.16 12.0 0.6 0.5 10.4 0.1 2.0 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3198 PF11433.8 CCM02036.1 - 0.23 11.3 0.1 0.23 11.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3198) Sipho_Gp157 PF05565.11 CCM02036.1 - 0.88 9.6 7.4 0.45 10.5 1.2 2.2 2 0 0 2 2 2 0 Siphovirus Gp157 PEP-utilisers_N PF05524.13 CCM02036.1 - 1.6 8.9 5.5 0.66 10.2 1.1 2.3 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal Prefoldin PF02996.17 CCM02036.1 - 2.9 7.8 8.8 5.1 7.0 0.5 3.4 3 1 0 3 3 3 0 Prefoldin subunit Phage_lysis PF03245.13 CCM02037.1 - 0.015 15.4 0.5 0.031 14.4 0.5 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein Peptidase_S10 PF00450.22 CCM02038.1 - 4.6e-101 339.3 0.0 5.7e-101 338.9 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase zf-ANAPC11 PF12861.7 CCM02038.1 - 0.037 14.1 1.4 0.077 13.1 0.3 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Aldo_ket_red PF00248.21 CCM02039.1 - 1.5e-67 227.9 0.0 1.8e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AsnA PF03590.15 CCM02039.1 - 0.014 15.2 0.1 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 Aspartate-ammonia ligase Complex1_LYR PF05347.15 CCM02042.1 - 3.9e-13 49.2 0.7 5e-13 48.9 0.7 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CCM02042.1 - 0.041 14.6 0.3 0.045 14.5 0.3 1.1 1 0 0 1 1 1 0 Complex1_LYR-like Pkinase PF00069.25 CCM02043.1 - 1.3e-41 142.8 0.0 1.9e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02043.1 - 2.6e-20 72.8 0.0 4.2e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM02043.1 - 2.7e-08 33.5 0.0 4.5e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCM02043.1 - 0.0014 18.6 3.7 0.019 14.9 0.6 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCM02043.1 - 0.04 13.3 0.1 0.31 10.3 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 CCM02043.1 - 0.23 10.4 0.0 0.34 9.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF4692 PF15763.5 CCM02043.1 - 4 7.9 5.9 6.6 7.2 5.9 1.3 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Phage_lysis PF03245.13 CCM02046.1 - 0.016 15.3 1.0 0.025 14.7 0.5 1.5 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein FTA4 PF13093.6 CCM02047.1 - 0.0091 15.9 0.2 0.76 9.6 0.0 2.2 2 0 0 2 2 2 2 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF3198 PF11433.8 CCM02047.1 - 0.03 14.2 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3198) Sipho_Gp157 PF05565.11 CCM02047.1 - 0.24 11.4 6.4 0.21 11.6 0.9 2.1 2 0 0 2 2 2 0 Siphovirus Gp157 PEP-utilisers_N PF05524.13 CCM02047.1 - 0.34 11.1 4.5 0.16 12.2 0.9 2.1 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal Mod_r PF07200.13 CCM02048.1 - 0.00012 22.2 4.7 0.07 13.2 0.9 3.7 4 0 0 4 4 4 2 Modifier of rudimentary (Mod(r)) protein ChitinaseA_N PF08329.10 CCM02048.1 - 0.0039 16.8 0.3 0.017 14.8 0.0 2.1 1 1 1 2 2 2 1 Chitinase A, N-terminal domain DUF4407 PF14362.6 CCM02048.1 - 0.0058 16.0 0.3 0.0058 16.0 0.3 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) Paramyx_P_V_C PF03210.13 CCM02048.1 - 0.079 12.7 0.1 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal Baculo_PEP_C PF04513.12 CCM02048.1 - 0.62 10.1 3.6 3.1 7.8 0.7 3.0 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.6 CCM02048.1 - 1.4 8.2 13.5 0.37 10.1 3.9 3.2 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.22 CCM02048.1 - 1.5 9.1 11.5 8.8 6.6 4.8 3.7 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain CLZ PF16526.5 CCM02048.1 - 1.7 9.1 7.9 3.2 8.2 0.4 3.8 3 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 CCM02048.1 - 1.7 9.1 10.1 28 5.3 0.2 4.0 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.21 CCM02048.1 - 2 8.6 6.7 1.1 9.4 0.3 3.0 2 1 0 2 2 2 0 bZIP transcription factor DUF1664 PF07889.12 CCM02048.1 - 2.7 8.1 11.1 1.1 9.3 3.5 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 CCM02048.1 - 3.1 8.1 10.1 2.2 8.6 2.3 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) YabA PF06156.13 CCM02048.1 - 3.4 8.4 6.0 16 6.2 3.7 3.1 2 1 1 3 3 3 0 Initiation control protein YabA Laminin_II PF06009.12 CCM02048.1 - 4.9 7.2 10.0 4.1 7.4 0.2 3.6 3 1 1 4 4 4 0 Laminin Domain II TBCC_N PF16752.5 CCM02048.1 - 6.2 7.3 8.8 0.82 10.1 1.5 2.8 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain TolA_bind_tri PF16331.5 CCM02048.1 - 6.5 6.9 9.4 6.1 7.0 3.7 3.2 2 1 0 2 2 2 0 TolA binding protein trimerisation FMN_dh PF01070.18 CCM02050.1 - 4.3e-102 341.7 0.0 6.4e-102 341.1 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 CCM02050.1 - 6.4e-07 29.1 0.3 1e-06 28.4 0.3 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 CCM02050.1 - 0.00012 21.4 0.2 0.00019 20.7 0.2 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CCM02050.1 - 0.00021 20.4 1.1 0.00042 19.4 0.9 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.21 CCM02050.1 - 0.0011 18.2 0.7 0.01 15.1 0.0 2.1 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase ThiG PF05690.14 CCM02050.1 - 0.0049 16.2 1.3 0.23 10.7 0.1 2.5 2 1 1 3 3 3 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CCM02050.1 - 0.035 13.6 0.3 0.11 11.9 0.3 1.8 1 1 0 1 1 1 0 Histidine biosynthesis protein DHHA2 PF02833.14 CCM02051.1 - 5.2e-28 98.0 0.0 8.3e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 CCM02051.1 - 3.4e-12 46.5 0.0 6.7e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 DHH family Hydrolase_4 PF12146.8 CCM02052.1 - 5.8e-54 182.9 0.0 6.9e-54 182.6 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM02052.1 - 1e-14 55.7 0.1 1.3e-14 55.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCM02052.1 - 1.9e-13 50.7 0.1 1.7e-10 41.0 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM02052.1 - 9.7e-06 25.2 0.0 0.0029 17.1 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family PhoPQ_related PF10142.9 CCM02052.1 - 1.9e-05 23.5 0.0 2.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DLH PF01738.18 CCM02052.1 - 0.00036 20.1 0.0 0.074 12.6 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family AXE1 PF05448.12 CCM02052.1 - 0.0033 16.2 0.1 0.5 9.0 0.0 2.3 2 1 0 2 2 2 2 Acetyl xylan esterase (AXE1) Thioesterase PF00975.20 CCM02052.1 - 0.028 14.5 0.3 0.096 12.8 0.3 1.8 1 1 0 1 1 1 0 Thioesterase domain DUF1495 PF07381.11 CCM02052.1 - 0.082 12.7 0.0 0.26 11.2 0.0 1.8 2 0 0 2 2 2 0 Winged helix DNA-binding domain (DUF1495) Abhydrolase_5 PF12695.7 CCM02052.1 - 0.16 11.7 0.0 25 4.6 0.0 2.7 3 0 0 3 3 3 0 Alpha/beta hydrolase family Pkinase_fungal PF17667.1 CCM02054.1 - 6e-13 48.3 0.0 6.1e-13 48.3 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase AMP-binding PF00501.28 CCM02055.1 - 3.4e-67 226.9 4.0 1.7e-65 221.3 4.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM02055.1 - 7e-06 26.9 0.1 1.6e-05 25.8 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain p450 PF00067.22 CCM02057.1 - 3e-56 191.1 0.0 3.8e-56 190.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TH1 PF04858.13 CCM02058.1 - 0.086 11.5 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 TH1 protein Pkinase_fungal PF17667.1 CCM02059.1 - 1.7e-09 36.9 0.0 2.3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF630 PF04783.12 CCM02059.1 - 0.13 12.5 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF630) PMSR PF01625.21 CCM02060.1 - 1.7e-57 193.9 0.5 3.3e-57 193.0 0.5 1.4 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase UCR_hinge PF02320.16 CCM02060.1 - 7.7e-13 48.5 1.6 1.6e-12 47.4 1.6 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Ribosomal_60s PF00428.19 CCM02060.1 - 0.3 11.7 13.0 1.2 9.8 13.2 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3391 PF11871.8 CCM02060.1 - 2.7 8.5 5.1 4.9 7.7 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) IATP PF04568.12 CCM02062.1 - 0.0024 18.3 3.6 0.0024 18.3 3.6 1.6 1 1 1 2 2 2 1 Mitochondrial ATPase inhibitor, IATP T2SSM PF04612.12 CCM02062.1 - 0.037 14.1 1.7 0.043 13.9 1.7 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Myb_DNA-bind_6 PF13921.6 CCM02063.1 - 1.7e-11 44.2 0.2 4.9e-11 42.7 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain HSA PF07529.13 CCM02063.1 - 3.7e-11 43.2 1.7 3.7e-11 43.2 1.7 4.7 4 1 0 4 4 4 1 HSA Myb_DNA-binding PF00249.31 CCM02063.1 - 1.5e-07 31.5 0.2 3.9e-07 30.2 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CCM02063.1 - 0.018 15.2 0.1 0.057 13.6 0.1 1.8 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Hamartin PF04388.12 CCM02063.1 - 1.2 7.7 35.1 2.5 6.7 35.1 1.6 1 0 0 1 1 1 0 Hamartin protein SMI1_KNR4 PF09346.10 CCM02064.1 - 3.5e-21 76.0 0.0 6e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) CoA_trans PF01144.23 CCM02065.1 - 1.8e-94 315.2 5.7 9.1e-56 188.7 0.6 2.1 2 0 0 2 2 2 2 Coenzyme A transferase Mal_decarbox_Al PF16957.5 CCM02065.1 - 0.0025 16.2 0.6 0.0047 15.3 0.5 1.4 1 1 1 2 2 2 1 Malonate decarboxylase, alpha subunit, transporter CoA_trans PF01144.23 CCM02066.1 - 9.9e-104 345.4 2.6 3.6e-59 199.8 0.1 2.1 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 CCM02066.1 - 0.0022 18.0 0.0 0.0047 16.9 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain EIIBC-GUT_N PF03612.14 CCM02066.1 - 0.065 13.0 0.1 0.54 10.0 0.0 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Cofilin_ADF PF00241.20 CCM02067.1 - 2.4e-32 111.3 0.0 3.5e-15 55.9 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein FYVE PF01363.21 CCM02068.1 - 1.5e-17 63.5 2.3 2.5e-17 62.7 2.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger Rbsn PF11464.8 CCM02068.1 - 2.1e-13 49.7 1.6 4.5e-13 48.7 1.6 1.6 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-C2HC5 PF06221.13 CCM02068.1 - 0.0049 16.8 4.2 0.0049 16.8 4.2 1.8 2 0 0 2 2 2 1 Putative zinc finger motif, C2HC5-type SOG2 PF10428.9 CCM02069.1 - 2.5e-89 300.8 0.1 2.5e-89 300.8 0.1 2.4 2 0 0 2 2 2 1 RAM signalling pathway protein LRR_8 PF13855.6 CCM02069.1 - 4.4e-11 42.4 2.2 7.2e-05 22.5 0.1 3.7 2 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 CCM02069.1 - 8.9e-09 35.5 0.9 3.2e-05 24.2 0.1 4.4 4 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCM02069.1 - 0.19 12.4 0.9 33 5.6 0.1 3.6 2 1 0 2 2 2 0 Leucine Rich Repeat CHDCT2 PF08074.11 CCM02069.1 - 0.52 10.5 1.8 19 5.4 0.7 2.4 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain PNTB PF02233.16 CCM02070.1 - 1.7e-121 406.4 31.3 1.7e-121 406.4 31.3 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CCM02070.1 - 4.3e-48 163.4 3.0 2e-47 161.3 0.0 2.9 2 1 1 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CCM02070.1 - 3.8e-44 150.3 0.1 8.9e-44 149.1 0.1 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 CCM02070.1 - 3.3e-31 107.6 3.7 3.3e-31 107.6 3.7 4.8 2 1 3 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch Git3 PF11710.8 CCM02070.1 - 0.072 12.9 0.2 0.15 11.8 0.2 1.5 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 TruB_N PF01509.18 CCM02071.1 - 3.1e-23 82.8 0.7 3.4e-12 47.0 0.8 3.0 1 1 2 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CCM02071.1 - 5.4e-07 29.7 0.0 1.5e-06 28.3 0.0 1.8 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain HSP70 PF00012.20 CCM02072.1 - 6.3e-62 209.6 2.2 7e-62 209.4 2.2 1.0 1 0 0 1 1 1 1 Hsp70 protein Porin_3 PF01459.22 CCM02073.1 - 1.7e-78 263.8 3.5 2.4e-78 263.3 3.5 1.2 1 0 0 1 1 1 1 Eukaryotic porin ABC_tran PF00005.27 CCM02074.1 - 7.3e-26 91.3 0.0 1.4e-25 90.4 0.0 1.4 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 CCM02074.1 - 4e-07 30.1 0.1 0.018 14.8 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM02074.1 - 1.7e-06 27.6 0.0 0.00023 20.7 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCM02074.1 - 0.00021 21.0 0.0 0.00045 19.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM02074.1 - 0.00027 21.3 0.1 0.0004 20.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCM02074.1 - 0.00041 20.3 0.0 0.0007 19.5 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 CCM02074.1 - 0.00043 20.6 0.0 0.0015 18.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CCM02074.1 - 0.0012 19.3 0.1 0.0023 18.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 CCM02074.1 - 0.0016 18.6 0.0 0.026 14.7 0.0 2.6 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CCM02074.1 - 0.0032 17.2 0.0 0.011 15.4 0.0 1.8 2 1 1 3 3 3 1 AAA domain NACHT PF05729.12 CCM02074.1 - 0.0035 17.3 0.1 0.0092 15.9 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 CCM02074.1 - 0.008 16.7 0.0 0.021 15.3 0.0 1.7 2 1 0 2 2 2 1 AAA domain AAA_13 PF13166.6 CCM02074.1 - 0.015 14.0 0.0 0.92 8.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CCM02074.1 - 0.062 13.3 0.0 0.098 12.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 CCM02074.1 - 0.073 13.2 0.0 0.2 11.8 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase PCB_OB PF17092.5 CCM02074.1 - 0.08 13.7 0.1 1.8 9.4 0.1 2.2 2 0 0 2 2 2 0 Penicillin-binding protein OB-like domain ABC_ATPase PF09818.9 CCM02074.1 - 0.083 11.7 0.4 1.1 7.9 0.1 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DUF815 PF05673.13 CCM02074.1 - 0.11 11.7 0.1 1.7 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 CCM02074.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MeaB PF03308.16 CCM02074.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4210 PF13915.6 CCM02074.1 - 0.15 12.7 0.0 13 6.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4210) Viral_helicase1 PF01443.18 CCM02074.1 - 0.15 11.7 0.0 0.34 10.6 0.1 1.6 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase AAA_27 PF13514.6 CCM02074.1 - 0.16 11.6 0.1 0.27 10.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCM02074.1 - 0.16 12.0 0.0 2.9 7.9 0.0 2.6 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) CbiA PF01656.23 CCM02074.1 - 0.17 11.9 0.4 0.48 10.5 0.2 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_2 PF03668.15 CCM02074.1 - 0.21 10.9 0.0 0.33 10.2 0.0 1.3 1 0 0 1 1 1 0 P-loop ATPase protein family YabA PF06156.13 CCM02075.1 - 0.0026 18.4 1.2 0.0026 18.4 1.2 3.8 3 1 1 4 4 3 1 Initiation control protein YabA OmpH PF03938.14 CCM02075.1 - 0.0039 17.5 1.7 0.0039 17.5 1.7 3.0 3 0 0 3 3 3 1 Outer membrane protein (OmpH-like) FlaC_arch PF05377.11 CCM02075.1 - 0.011 16.2 5.3 0.075 13.4 0.2 3.9 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) KfrA_N PF11740.8 CCM02075.1 - 0.03 15.0 2.5 0.03 15.0 2.5 3.4 4 0 0 4 4 4 0 Plasmid replication region DNA-binding N-term ABC_tran_CTD PF16326.5 CCM02075.1 - 0.033 14.4 14.9 0.33 11.2 0.5 4.6 4 1 0 4 4 3 0 ABC transporter C-terminal domain DNA_primase_lrg PF04104.14 CCM02075.1 - 0.051 13.0 0.2 0.051 13.0 0.2 2.1 3 0 0 3 3 3 0 Eukaryotic and archaeal DNA primase, large subunit Med9 PF07544.13 CCM02075.1 - 0.056 13.5 7.2 1.3 9.2 1.4 3.4 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 CSTF2_hinge PF14327.6 CCM02075.1 - 0.056 13.9 3.0 0.21 12.1 3.0 1.9 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 Musclin PF11037.8 CCM02075.1 - 0.065 13.2 1.6 0.57 10.1 0.5 2.5 2 0 0 2 2 2 0 Insulin-resistance promoting peptide in skeletal muscle TetR_C_35 PF18556.1 CCM02075.1 - 0.068 13.3 1.5 0.094 12.9 0.3 1.9 2 0 0 2 2 1 0 Bacterial Tetracyclin repressor, C-terminal domain ATG16 PF08614.11 CCM02075.1 - 0.084 13.1 19.5 0.06 13.6 2.6 3.0 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DivIC PF04977.15 CCM02075.1 - 0.11 12.3 0.2 0.11 12.3 0.2 3.9 3 1 0 3 3 3 0 Septum formation initiator GAS PF13851.6 CCM02075.1 - 0.11 11.8 12.4 0.16 11.3 0.7 3.4 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4140 PF13600.6 CCM02075.1 - 0.23 11.9 11.6 0.54 10.7 2.8 3.4 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Phage_Nu1 PF07471.12 CCM02075.1 - 0.25 11.1 0.0 0.25 11.1 0.0 2.3 3 0 0 3 3 3 0 Phage DNA packaging protein Nu1 DUF4407 PF14362.6 CCM02075.1 - 0.6 9.4 16.2 0.15 11.4 9.8 2.7 2 1 0 3 3 3 0 Domain of unknown function (DUF4407) MetOD2 PF18548.1 CCM02075.1 - 0.69 10.1 12.6 0.27 11.4 0.4 4.1 4 0 0 4 4 4 0 Metanogen output domain 2 DUF16 PF01519.16 CCM02075.1 - 0.74 10.3 7.3 1.8 9.1 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function DUF16 YscO-like PF16789.5 CCM02075.1 - 1 9.4 10.3 4.5 7.3 0.6 2.9 3 0 0 3 3 2 0 YscO-like protein DUF1664 PF07889.12 CCM02075.1 - 1.5 8.8 11.7 4.7 7.3 0.3 4.0 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) MutS_IV PF05190.18 CCM02075.1 - 1.6 9.1 6.6 4.2 7.8 0.9 3.4 3 0 0 3 3 3 0 MutS family domain IV DUF724 PF05266.14 CCM02075.1 - 1.9 8.3 8.9 0.55 10.0 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF724) BLOC1_2 PF10046.9 CCM02075.1 - 2.1 8.7 13.7 0.31 11.4 1.1 3.8 4 0 0 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sipho_Gp157 PF05565.11 CCM02075.1 - 2.9 7.9 9.2 0.13 12.2 1.8 2.5 2 1 0 2 2 2 0 Siphovirus Gp157 Syntaxin-6_N PF09177.11 CCM02075.1 - 3.7 8.2 17.2 5.8 7.5 3.2 4.2 3 1 1 4 4 4 0 Syntaxin 6, N-terminal Golgin_A5 PF09787.9 CCM02075.1 - 4.4 6.7 20.2 6.1 6.2 2.2 3.4 2 1 1 3 3 3 0 Golgin subfamily A member 5 RNase_E_G PF10150.9 CCM02075.1 - 6.9 6.0 10.5 0.6 9.5 1.6 2.8 3 1 0 3 3 3 0 Ribonuclease E/G family TMPIT PF07851.13 CCM02075.1 - 8.1 5.6 10.6 7.5 5.7 0.4 2.7 3 0 0 3 3 3 0 TMPIT-like protein DUF2203 PF09969.9 CCM02075.1 - 9.8 6.9 13.8 1.2 9.8 0.2 4.1 3 1 2 5 5 5 0 Uncharacterized conserved protein (DUF2203) Nuc_sug_transp PF04142.15 CCM02077.1 - 1.9e-77 260.5 4.4 3.2e-77 259.8 4.4 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 CCM02077.1 - 1.5e-05 24.4 3.0 1.5e-05 24.4 3.0 1.7 2 1 0 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 CCM02077.1 - 5.2e-05 23.4 1.0 5.2e-05 23.4 1.0 3.1 3 0 0 3 3 3 1 EamA-like transporter family CRT-like PF08627.10 CCM02077.1 - 0.00038 19.5 1.4 0.00057 18.9 1.4 1.2 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 CCM02077.1 - 0.00077 18.8 3.2 0.00077 18.8 3.2 1.9 2 1 0 2 2 2 1 UAA transporter family COX2_TM PF02790.15 CCM02077.1 - 0.16 12.2 3.1 3.6 7.8 0.0 3.3 4 0 0 4 4 4 0 Cytochrome C oxidase subunit II, transmembrane domain Exo_endo_phos PF03372.23 CCM02078.1 - 4.4e-13 49.3 0.0 6.7e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family OTU PF02338.19 CCM02079.1 - 2e-05 25.1 0.0 3e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease Arm-DNA-bind_4 PF14657.6 CCM02079.1 - 0.23 11.3 0.1 0.39 10.5 0.1 1.3 1 0 0 1 1 1 0 Arm DNA-binding domain Tom37 PF10568.9 CCM02080.1 - 6.2e-24 84.7 0.2 1.7e-23 83.2 0.1 1.8 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 CCM02080.1 - 2.2e-06 27.4 0.1 4.2e-06 26.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CCM02080.1 - 2.4e-06 28.2 0.0 5.9e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 CCM02080.1 - 0.00086 19.3 0.2 0.0016 18.5 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MotB_plug PF13677.6 CCM02080.1 - 0.023 14.3 0.4 5.5 6.7 0.1 2.5 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB TAFII55_N PF04658.13 CCM02081.1 - 1e-56 191.1 0.6 1e-56 191.1 0.6 2.1 2 0 0 2 2 2 1 TAFII55 protein conserved region SDA1 PF05285.12 CCM02081.1 - 1.1 8.6 25.1 1.9 7.8 25.1 1.4 1 0 0 1 1 1 0 SDA1 Gaa1 PF04114.14 CCM02082.1 - 1.3e-105 354.3 2.1 5e-105 352.4 2.1 1.8 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component LUC7 PF03194.15 CCM02082.1 - 2.3e-34 119.2 0.2 2.3e-34 119.2 0.2 2.5 2 1 0 2 2 2 1 LUC7 N_terminus DnaJ PF00226.31 CCM02082.1 - 4.3e-13 49.2 0.1 1.3e-12 47.7 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Ank_4 PF13637.6 CCM02082.1 - 1e-07 32.3 0.1 6.8e-07 29.7 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM02082.1 - 3.1e-06 27.7 0.0 9.5e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCM02082.1 - 2.7e-05 24.2 0.1 0.18 12.4 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CCM02082.1 - 0.0016 18.7 0.0 0.011 16.0 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CCM02082.1 - 0.031 14.7 0.1 18 6.0 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat FRG1 PF06229.12 CCM02083.1 - 6.2e-28 97.8 0.2 6.2e-28 97.8 0.2 1.6 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 CCM02083.1 - 0.00059 20.0 0.0 0.00098 19.3 0.0 1.4 1 0 0 1 1 1 1 Fascin domain BRF1 PF07741.13 CCM02083.1 - 7 7.1 13.9 7.5 7.0 0.5 2.5 2 1 0 2 2 2 0 Brf1-like TBP-binding domain Ribosomal_L26 PF16906.5 CCM02084.1 - 2.4e-37 127.2 4.2 3.8e-37 126.6 4.2 1.3 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 CCM02084.1 - 1.2e-08 34.6 3.9 1.2e-08 34.6 3.9 2.1 2 0 0 2 2 2 1 KOW motif ATP-synt_D PF01813.17 CCM02085.1 - 6.2e-72 241.6 2.3 8.3e-72 241.2 2.3 1.2 1 0 0 1 1 1 1 ATP synthase subunit D XAP5 PF04921.14 CCM02086.1 - 1.7e-87 293.3 5.7 1.7e-87 293.3 5.7 2.2 2 0 0 2 2 2 1 XAP5, circadian clock regulator Cir_N PF10197.9 CCM02086.1 - 0.3 11.3 0.2 0.3 11.3 0.2 5.1 4 2 1 5 5 5 0 N-terminal domain of CBF1 interacting co-repressor CIR Acyl-CoA_ox_N PF14749.6 CCM02086.1 - 2.9 8.5 7.1 0.26 11.8 2.1 1.9 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal TRAPP PF04051.16 CCM02087.1 - 4.2e-33 114.1 0.0 5.4e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component UCH PF00443.29 CCM02089.1 - 7.6e-26 91.2 0.5 1.7e-25 90.0 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM02089.1 - 1.9e-12 47.4 0.1 3.8e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CCM02089.1 - 1.7e-06 27.7 0.1 4.3e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family DUSP PF06337.12 CCM02089.1 - 0.00012 22.6 0.0 0.043 14.4 0.0 3.1 3 0 0 3 3 3 1 DUSP domain zf-RanBP PF00641.18 CCM02089.1 - 0.0018 17.5 4.5 0.0018 17.5 4.5 2.5 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others zf-FPG_IleRS PF06827.14 CCM02089.1 - 0.13 12.1 6.3 9.7 6.2 0.5 4.2 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS WBS_methylT PF12589.8 CCM02090.1 - 3.2e-09 37.4 0.8 5.7e-09 36.6 0.8 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CCM02090.1 - 5.9e-09 36.5 0.0 1.2e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM02090.1 - 1.7e-07 31.8 0.0 3.9e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM02090.1 - 0.00034 21.3 0.1 0.0011 19.7 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM02090.1 - 0.002 18.0 0.0 0.0041 17.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM02090.1 - 0.0048 16.7 0.0 0.012 15.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ras PF00071.22 CCM02091.1 - 1.6e-47 161.1 0.0 2.1e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM02091.1 - 2.8e-27 95.3 0.0 5e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM02091.1 - 3.6e-08 33.1 0.0 5.1e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM02091.1 - 0.025 14.0 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF5118 PF17162.4 CCM02091.1 - 0.075 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) STAS PF01740.21 CCM02091.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 STAS domain MFS_1 PF07690.16 CCM02092.1 - 1.1e-49 169.3 50.5 1.1e-49 169.3 50.5 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM02092.1 - 1.5e-16 60.0 16.1 2.4e-16 59.3 16.1 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM02092.1 - 2.7e-13 49.6 13.7 2.7e-13 49.6 13.7 2.8 3 1 0 3 3 3 1 Sugar (and other) transporter DUF3522 PF12036.8 CCM02092.1 - 0.0069 16.7 1.3 0.0069 16.7 1.3 2.9 4 0 0 4 4 4 1 Protein of unknown function (DUF3522) Vac_ImportDeg PF09783.9 CCM02093.1 - 1.4e-51 174.6 0.0 4.4e-51 172.9 0.0 1.7 1 1 0 1 1 1 1 Vacuolar import and degradation protein Pkinase PF00069.25 CCM02094.1 - 5e-23 81.8 0.0 6.3e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02094.1 - 3.4e-12 46.2 0.0 4.8e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM02094.1 - 7.5e-08 31.6 0.0 1e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCM02094.1 - 0.0053 16.7 0.1 2.8 7.8 0.0 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family JmjC PF02373.22 CCM02095.1 - 1.3e-11 45.0 0.0 3.2e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase CENP-Q PF13094.6 CCM02095.1 - 0.019 15.2 2.3 0.067 13.4 2.3 1.9 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit KELK PF15796.5 CCM02095.1 - 0.65 10.5 4.1 1.6 9.2 4.1 1.7 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase LEA_2 PF03168.13 CCM02097.1 - 0.00097 19.6 0.2 0.0019 18.7 0.0 1.7 2 0 0 2 2 2 1 Late embryogenesis abundant protein Vac7 PF12751.7 CCM02097.1 - 0.0041 16.6 0.0 0.0062 16.0 0.0 1.2 1 0 0 1 1 1 1 Vacuolar segregation subunit 7 DUF1356 PF07092.12 CCM02097.1 - 0.021 14.1 0.9 0.031 13.6 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) DUF726 PF05277.12 CCM02098.1 - 2.5e-85 286.4 3.0 3.4e-85 286.0 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_8 PF06259.12 CCM02098.1 - 4.1e-05 23.3 0.4 0.0002 21.1 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase Thioesterase PF00975.20 CCM02098.1 - 0.00046 20.4 0.0 0.00085 19.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Cutinase PF01083.22 CCM02098.1 - 0.0038 17.2 0.0 0.0076 16.2 0.0 1.4 1 0 0 1 1 1 1 Cutinase Abhydrolase_6 PF12697.7 CCM02098.1 - 0.88 10.1 4.0 0.47 11.0 0.1 2.3 2 1 0 3 3 3 0 Alpha/beta hydrolase family Peptidase_M41 PF01434.18 CCM02099.1 - 7.2e-58 195.6 0.1 1.2e-57 194.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CCM02099.1 - 2e-43 148.0 0.0 4e-43 147.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCM02099.1 - 4.3e-05 23.3 0.1 0.00025 20.8 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CCM02099.1 - 0.00013 22.0 0.1 0.00071 19.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CCM02099.1 - 0.00021 20.6 0.0 0.00041 19.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 CCM02099.1 - 0.0003 21.2 5.8 0.0036 17.7 0.1 3.4 3 1 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 CCM02099.1 - 0.00051 20.3 1.8 0.0033 17.7 0.3 2.7 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.6 CCM02099.1 - 0.0036 17.8 0.0 0.0087 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CCM02099.1 - 0.004 17.3 0.0 0.02 15.0 0.0 2.2 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 CCM02099.1 - 0.0043 16.6 0.7 0.4 10.2 0.4 2.6 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CCM02099.1 - 0.0047 16.3 0.3 0.011 15.2 0.3 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CCM02099.1 - 0.0054 16.9 0.0 0.015 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_lid_3 PF17862.1 CCM02099.1 - 0.0058 16.4 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 CCM02099.1 - 0.007 16.1 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 CCM02099.1 - 0.017 15.4 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM02099.1 - 0.043 13.7 1.5 0.18 11.7 0.0 2.6 3 0 0 3 3 3 0 NACHT domain ATPase_2 PF01637.18 CCM02099.1 - 0.054 13.4 1.3 2.2 8.1 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CCM02099.1 - 0.056 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CCM02099.1 - 0.14 12.5 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CCM02099.1 - 0.15 11.2 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 CCM02099.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCM02099.1 - 0.2 11.1 0.2 0.82 9.2 0.2 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region RNA_pol_Rpb2_6 PF00562.28 CCM02100.1 - 2e-109 366.2 0.7 4.7e-107 358.4 0.1 2.1 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCM02100.1 - 1.4e-55 188.0 0.0 2.5e-55 187.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CCM02100.1 - 1e-30 106.8 0.0 2.9e-30 105.3 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CCM02100.1 - 1.5e-27 95.8 0.1 4.2e-27 94.4 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 CCM02100.1 - 1.2e-24 86.4 2.6 2.7e-24 85.2 1.4 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 CCM02100.1 - 2.1e-20 72.7 0.0 5.7e-20 71.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 CCM02100.1 - 2.9e-11 43.7 0.2 8.4e-11 42.3 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RecR PF02132.15 CCM02100.1 - 0.12 12.0 0.1 0.24 11.0 0.1 1.5 1 0 0 1 1 1 0 RecR protein UQ_con PF00179.26 CCM02101.1 - 1.8e-47 160.5 0.0 2e-47 160.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCM02101.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.5 1 1 0 1 1 1 0 Prokaryotic E2 family B UPF0261 PF06792.11 CCM02102.1 - 4.2e-152 506.8 0.0 4.7e-152 506.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) PEP_hydrolase PF09370.10 CCM02103.1 - 9.7e-134 444.7 0.3 1.1e-133 444.5 0.3 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 CCM02103.1 - 0.0099 15.3 0.1 0.017 14.5 0.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase Got1 PF04178.12 CCM02105.1 - 1.2e-27 96.5 8.8 1.8e-27 96.0 8.8 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family TM_helix PF05552.12 CCM02105.1 - 0.029 14.3 3.2 4.8 7.2 0.7 2.4 2 0 0 2 2 2 0 Conserved TM helix DUF2070 PF09843.9 CCM02105.1 - 0.13 10.6 1.7 0.15 10.3 1.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Nup192 PF11894.8 CCM02106.1 - 1.3e-240 801.6 0.0 1.7e-240 801.3 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Acetyltransf_1 PF00583.25 CCM02107.1 - 1.5e-15 57.4 0.0 2e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM02107.1 - 1.4e-09 38.0 0.0 1.8e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM02107.1 - 1.5e-09 38.1 0.0 2.2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM02107.1 - 6.2e-08 32.5 0.0 9.3e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CCM02107.1 - 2e-05 25.3 0.0 2.8e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCM02107.1 - 3.6e-05 23.9 0.0 5.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CCM02107.1 - 7.3e-05 22.5 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCM02107.1 - 0.064 13.4 0.0 0.075 13.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HSP70 PF00012.20 CCM02108.1 - 8.1e-262 869.8 3.3 9.1e-262 869.6 3.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCM02108.1 - 1.7e-19 69.9 0.2 1.7e-18 66.5 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.10 CCM02108.1 - 0.0011 18.0 0.4 0.064 12.2 0.2 2.2 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.16 CCM02108.1 - 0.025 14.3 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 CCM02108.1 - 0.076 12.3 0.1 0.2 10.9 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Spectrin PF00435.21 CCM02108.1 - 0.09 13.3 4.6 5.4 7.6 0.0 3.4 3 1 0 3 3 3 0 Spectrin repeat AA_permease_2 PF13520.6 CCM02109.1 - 1.7e-65 221.6 56.9 2e-65 221.3 56.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCM02109.1 - 5.4e-13 48.4 52.3 1.1e-12 47.3 52.3 1.4 1 1 0 1 1 1 1 Amino acid permease 4HBT PF03061.22 CCM02110.1 - 1.2e-05 25.6 0.1 0.17 12.2 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily DUF4729 PF15866.5 CCM02111.1 - 0.00013 21.4 0.6 0.18 11.1 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4729) Sina PF03145.16 CCM02111.1 - 0.00045 20.2 0.7 0.42 10.5 0.2 2.1 1 1 1 2 2 2 2 Seven in absentia protein family Macoilin PF09726.9 CCM02111.1 - 0.022 13.3 2.0 0.029 12.9 2.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF1644 PF07800.12 CCM02111.1 - 0.077 13.1 0.3 6.3 6.8 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) Pkinase_Tyr PF07714.17 CCM02112.1 - 4.7e-47 160.4 0.0 6.4e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM02112.1 - 5.1e-46 157.2 0.0 7.7e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C1_1 PF00130.22 CCM02112.1 - 5e-08 32.7 0.9 9.8e-08 31.8 0.9 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 CCM02112.1 - 0.011 15.6 2.1 0.021 14.7 2.1 1.4 1 0 0 1 1 1 0 PHD-finger APH PF01636.23 CCM02112.1 - 0.018 15.0 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CCM02112.1 - 0.019 14.4 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.16 CCM02112.1 - 0.023 15.0 0.4 0.046 14.0 0.4 1.4 1 0 0 1 1 1 0 C1 domain Pkinase_fungal PF17667.1 CCM02112.1 - 0.06 12.1 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 CCM02112.1 - 0.081 11.9 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain CKAP2_C PF15297.6 CCM02115.1 - 0.0032 16.6 0.1 0.0045 16.1 0.1 1.1 1 0 0 1 1 1 1 Cytoskeleton-associated protein 2 C-terminus EBV-NA3 PF05009.12 CCM02115.1 - 0.013 15.0 0.3 0.07 12.7 0.1 1.9 1 1 1 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Rap_GAP PF02145.15 CCM02116.1 - 4.5e-41 140.4 0.0 8.3e-41 139.6 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 CCM02116.1 - 4.8e-36 124.6 0.3 9.4e-31 107.2 0.0 3.3 3 0 0 3 3 3 3 Tuberin DUF3384 PF11864.8 CCM02116.1 - 5.6e-07 28.8 5.6 0.00048 19.2 0.0 3.4 3 1 1 4 4 4 2 Domain of unknown function (DUF3384) SF-assemblin PF06705.11 CCM02116.1 - 0.049 13.0 1.6 0.088 12.1 1.6 1.3 1 0 0 1 1 1 0 SF-assemblin/beta giardin GEN1_C PF18380.1 CCM02117.1 - 3.1e-29 101.9 0.0 1.3e-28 99.9 0.0 2.2 1 0 0 1 1 1 1 Holliday junction resolvase Gen1 C-terminal domain XPG_I PF00867.18 CCM02117.1 - 2.1e-18 66.4 0.0 4.8e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CCM02117.1 - 0.00075 19.9 0.0 0.0022 18.5 0.0 1.8 1 1 0 1 1 1 1 XPG N-terminal domain PBP1_TM PF14812.6 CCM02117.1 - 2.3 8.7 4.5 3.1 8.2 0.1 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CTP_transf_like PF01467.26 CCM02118.1 - 7.2e-21 74.9 0.0 6.9e-15 55.5 0.0 2.3 2 0 0 2 2 2 2 Cytidylyltransferase-like SapA PF02199.15 CCM02118.1 - 0.036 14.4 0.8 0.086 13.1 0.8 1.6 1 0 0 1 1 1 0 Saposin A-type domain Alpha-amylase PF00128.24 CCM02119.1 - 0.0016 18.1 0.0 0.0019 17.9 0.0 1.0 1 0 0 1 1 1 1 Alpha amylase, catalytic domain PduV-EutP PF10662.9 CCM02119.1 - 0.11 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation adh_short PF00106.25 CCM02120.1 - 2e-08 33.9 0.3 0.0023 17.4 0.0 3.3 2 1 0 2 2 2 2 short chain dehydrogenase Metallophos PF00149.28 CCM02121.1 - 7.7e-35 121.2 0.1 9.8e-35 120.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 CCM02121.1 - 0.004 16.8 0.0 0.0061 16.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain STPPase_N PF16891.5 CCM02121.1 - 0.0068 16.8 0.2 0.015 15.8 0.2 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Methyltransf_31 PF13847.6 CCM02122.1 - 8e-18 64.7 0.0 1.1e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM02122.1 - 1.4e-15 57.7 0.1 4.1e-15 56.3 0.2 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM02122.1 - 3.7e-15 56.3 0.2 1e-14 54.9 0.2 1.7 2 0 0 2 2 1 1 Methyltransferase domain CMAS PF02353.20 CCM02122.1 - 3.8e-15 55.9 0.0 5e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CCM02122.1 - 3.2e-09 36.8 0.0 4.7e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM02122.1 - 2.9e-08 34.4 0.0 6.1e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM02122.1 - 1.3e-07 31.2 0.1 2.6e-07 30.2 0.1 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 CCM02122.1 - 4.8e-05 23.0 0.0 7.1e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Sterol_MT_C PF08498.10 CCM02122.1 - 0.00019 21.7 0.0 0.0004 20.6 0.0 1.5 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal PCMT PF01135.19 CCM02122.1 - 0.00024 20.9 0.1 0.00041 20.2 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CCM02122.1 - 0.00055 19.9 0.0 0.00078 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 CCM02122.1 - 0.00094 18.4 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_9 PF08003.11 CCM02122.1 - 0.0012 17.8 0.0 0.002 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 CCM02122.1 - 0.005 16.3 0.0 0.007 15.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 CCM02122.1 - 0.014 15.0 0.1 0.022 14.4 0.1 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 CCM02122.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_15 PF09445.10 CCM02122.1 - 0.029 14.0 0.1 0.044 13.4 0.1 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_24 PF13578.6 CCM02122.1 - 0.032 15.3 0.0 0.067 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Pox_MCEL PF03291.16 CCM02122.1 - 0.034 13.3 0.1 0.049 12.7 0.1 1.2 1 0 0 1 1 1 0 mRNA capping enzyme Methyltransf_4 PF02390.17 CCM02122.1 - 0.053 13.0 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase VHS PF00790.19 CCM02123.1 - 1.9e-14 53.7 0.0 3.2e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 CCM02123.1 - 2.3e-11 43.8 0.2 3.9e-06 27.1 0.0 2.6 2 0 0 2 2 2 2 GAT domain RRM_1 PF00076.22 CCM02124.1 - 3.6e-33 113.2 0.1 4.1e-16 58.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM02124.1 - 1e-10 41.6 0.0 9.5e-06 25.7 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CCM02124.1 - 0.033 14.2 0.0 5.7 7.0 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Mito_fiss_reg PF05308.11 CCM02124.1 - 0.78 9.8 5.7 1.2 9.2 5.7 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator HEAT_2 PF13646.6 CCM02125.1 - 1.2e-05 25.6 4.2 8.1 6.9 0.0 6.8 4 2 1 5 5 5 2 HEAT repeats HEAT PF02985.22 CCM02125.1 - 0.00088 19.3 8.5 2.8 8.5 0.0 7.3 8 0 0 8 8 8 2 HEAT repeat RTP1_C1 PF10363.9 CCM02125.1 - 0.0009 19.4 0.3 0.86 9.8 0.0 5.5 4 2 1 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 VHS PF00790.19 CCM02125.1 - 0.0011 18.8 0.3 0.0085 15.9 0.0 2.5 2 0 0 2 2 2 1 VHS domain Adaptin_N PF01602.20 CCM02125.1 - 0.0085 14.7 7.6 0.52 8.8 0.0 4.6 5 1 1 6 6 6 2 Adaptin N terminal region Rit1_C PF17184.4 CCM02125.1 - 0.13 11.7 0.1 0.27 10.7 0.1 1.4 1 0 0 1 1 1 0 Rit1 N-terminal domain DNA_pol_phi PF04931.13 CCM02125.1 - 0.14 10.2 0.0 0.42 8.7 0.0 1.8 1 0 0 1 1 1 0 DNA polymerase phi HEAT_EZ PF13513.6 CCM02125.1 - 0.27 11.8 21.6 0.25 11.9 0.2 7.6 9 1 0 9 9 9 0 HEAT-like repeat Rsa3 PF14615.6 CCM02129.1 - 0.15 11.6 0.3 0.47 10.1 0.3 1.8 1 0 0 1 1 1 0 Ribosome-assembly protein 3 SMC_N PF02463.19 CCM02130.1 - 2.4e-63 213.5 0.3 4.8e-63 212.5 0.3 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCM02130.1 - 1.1e-30 106.3 3.7 2.5e-30 105.2 0.0 3.1 3 0 0 3 3 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCM02130.1 - 1.4e-14 54.7 4.3 6.9e-07 29.4 0.0 3.6 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM02130.1 - 4e-07 29.7 0.0 8.4e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CCM02130.1 - 5.6e-07 30.3 27.4 5.6e-07 30.3 27.4 6.8 2 2 2 4 4 2 1 AAA domain AAA_15 PF13175.6 CCM02130.1 - 1.3e-06 28.4 4.7 1.3e-06 28.4 4.7 4.5 1 1 1 4 4 4 1 AAA ATPase domain Sec8_exocyst PF04048.14 CCM02130.1 - 1.1e-05 25.3 7.5 1.1e-05 25.3 7.5 6.4 4 1 1 7 7 7 1 Sec8 exocyst complex component specific domain Spc7 PF08317.11 CCM02130.1 - 0.0011 18.0 5.8 0.0011 18.0 5.8 5.9 3 2 2 6 6 6 1 Spc7 kinetochore protein SbcCD_C PF13558.6 CCM02130.1 - 0.0027 17.9 0.0 0.011 15.9 0.0 2.2 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 CCM02130.1 - 0.1 13.1 0.0 0.1 13.1 0.0 5.6 4 1 0 5 5 4 0 ABC transporter AAA_22 PF13401.6 CCM02130.1 - 0.46 10.7 5.3 33 4.7 0.0 4.3 3 1 1 4 4 4 0 AAA domain DUF2939 PF11159.8 CCM02130.1 - 0.9 10.0 4.5 7.4 7.1 0.1 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2939) CbiG_C PF01890.16 CCM02130.1 - 2.7 8.6 9.1 1.3 9.6 0.3 3.2 2 1 1 3 3 3 0 Cobalamin synthesis G C-terminus Abhydrolase_3 PF07859.13 CCM02131.1 - 2.5e-66 223.6 0.0 3e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCM02131.1 - 7.3e-09 35.0 0.1 2.5e-08 33.3 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 CCM02131.1 - 2.7e-07 29.8 0.0 3.7e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 CCM02131.1 - 0.00014 21.4 0.0 0.0076 15.7 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 CCM02131.1 - 0.00042 19.3 0.0 0.00059 18.8 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme Glyco_transf_24 PF18404.1 CCM02132.1 - 2.4e-144 479.7 1.5 3.5e-144 479.1 1.5 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 CCM02132.1 - 2.8e-68 230.6 0.0 1e-65 222.3 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_13 PF18401.1 CCM02132.1 - 8.3e-42 142.3 0.1 4.8e-41 139.9 0.1 2.3 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 CCM02132.1 - 1.3e-41 142.6 0.1 2.8e-41 141.5 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 CCM02132.1 - 1.4e-37 128.2 0.0 2.4e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_15 PF18403.1 CCM02132.1 - 2.6e-31 109.2 0.0 1.1e-29 104.0 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 CCM02132.1 - 1.7e-05 24.5 0.0 2.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Oxidored_FMN PF00724.20 CCM02133.1 - 3.3e-67 227.2 0.0 4.2e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ACT PF01842.25 CCM02133.1 - 0.16 11.8 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 ACT domain Phage_holin_5_2 PF16079.5 CCM02134.1 - 0.0011 19.3 2.1 0.0011 19.3 2.1 2.2 2 0 0 2 2 2 1 Phage holin family Hol44, in holin superfamily V DUF5360 PF17314.2 CCM02134.1 - 0.16 12.1 6.2 0.29 11.2 6.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5360) DUF4131 PF13567.6 CCM02134.1 - 1.1 8.8 5.6 15 5.2 5.6 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) SGL PF08450.12 CCM02135.1 - 2.4e-22 79.7 0.0 4.6e-22 78.8 0.0 1.6 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 CCM02135.1 - 3.3e-06 27.1 0.0 2.3e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 CCM02135.1 - 0.0013 18.9 0.0 0.0041 17.3 0.0 1.9 1 0 0 1 1 1 1 Arylesterase Kelch_3 PF13415.6 CCM02135.1 - 0.025 14.9 0.0 13 6.2 0.0 3.1 2 0 0 2 2 2 0 Galactose oxidase, central domain YmzC PF14157.6 CCM02135.1 - 0.043 13.9 0.0 0.27 11.3 0.0 2.2 2 0 0 2 2 2 0 YmzC-like protein PD40 PF07676.12 CCM02135.1 - 0.073 13.0 0.4 5.3 7.1 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat adh_short_C2 PF13561.6 CCM02136.1 - 2.1e-63 214.0 2.1 2.6e-63 213.7 2.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM02136.1 - 4.3e-45 153.6 2.4 5.1e-45 153.3 2.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM02136.1 - 2.8e-09 37.2 1.4 4e-09 36.6 1.4 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCM02136.1 - 1.5e-05 24.5 0.0 2.1e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCM02136.1 - 0.00029 20.4 0.1 0.0015 18.1 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 CCM02136.1 - 0.013 15.4 0.2 1.3 9.1 0.1 2.3 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Ubie_methyltran PF01209.18 CCM02136.1 - 0.094 12.0 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family NPR3 PF03666.13 CCM02137.1 - 7 5.3 9.7 9.2 4.9 9.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 E1-E2_ATPase PF00122.20 CCM02138.1 - 1e-48 165.2 0.0 1e-48 165.2 0.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CCM02138.1 - 6.6e-17 62.5 0.2 2.2e-16 60.8 0.2 2.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCM02138.1 - 6.5e-13 48.2 0.1 1.6e-12 47.0 0.1 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCM02138.1 - 0.00037 20.3 0.0 0.00083 19.2 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCM02138.1 - 0.0052 16.8 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Choline_transpo PF04515.12 CCM02140.1 - 4.8e-56 190.3 1.2 4.8e-56 190.3 1.2 2.4 2 1 0 2 2 2 1 Plasma-membrane choline transporter Dicty_CAR PF05462.11 CCM02140.1 - 2 7.4 6.4 0.37 9.9 2.7 1.6 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor Aa_trans PF01490.18 CCM02143.1 - 1.1e-36 126.4 33.9 1.7e-36 125.9 33.9 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PDH PF02153.17 CCM02143.1 - 2.9e-14 52.7 0.0 4.8e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 CCM02143.1 - 0.0014 18.8 0.3 0.0043 17.2 0.0 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCM02143.1 - 0.012 16.1 0.0 0.032 14.8 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CCM02143.1 - 0.05 13.7 0.0 0.094 12.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CCM02143.1 - 0.12 11.7 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_N PF02776.18 CCM02144.1 - 7.4e-56 188.4 0.2 6.6e-55 185.4 0.1 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CCM02144.1 - 5.2e-47 159.5 0.7 8.2e-45 152.3 0.1 2.9 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCM02144.1 - 4.1e-40 136.7 1.5 6.6e-40 136.0 0.5 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain FAA_hydrolase PF01557.18 CCM02145.1 - 1.7e-56 191.3 0.0 2.2e-56 190.9 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family UCR_Fe-S_N PF10399.9 CCM02146.1 - 0.0034 16.7 8.2 0.009 15.3 8.2 1.7 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Auxin_canalis PF05703.11 CCM02146.1 - 0.084 12.8 4.4 0.11 12.5 4.4 1.1 1 0 0 1 1 1 0 Auxin canalisation DUF2561 PF10812.8 CCM02147.1 - 0.0002 21.4 1.6 0.00024 21.2 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2561) CD34_antigen PF06365.12 CCM02147.1 - 0.0005 19.7 0.1 0.00067 19.3 0.1 1.1 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF456 PF04306.13 CCM02147.1 - 0.0018 18.6 0.4 0.0025 18.1 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF456) TMEM51 PF15345.6 CCM02147.1 - 0.0023 17.8 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 TMEM154 PF15102.6 CCM02147.1 - 0.0034 17.3 0.2 0.005 16.7 0.0 1.6 2 0 0 2 2 1 1 TMEM154 protein family MFS_2 PF13347.6 CCM02147.1 - 0.0046 15.6 0.0 0.0053 15.4 0.0 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Shisa PF13908.6 CCM02147.1 - 0.0049 17.1 0.8 0.008 16.4 0.8 1.3 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator SARAF PF06682.12 CCM02147.1 - 0.0055 16.4 0.0 0.0069 16.1 0.0 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF4381 PF14316.6 CCM02147.1 - 0.0064 16.8 0.1 0.0097 16.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Herpes_gE PF02480.16 CCM02147.1 - 0.0082 14.9 0.5 0.0091 14.8 0.5 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.6 CCM02147.1 - 0.0085 16.9 0.6 0.01 16.7 0.0 1.6 2 0 0 2 2 1 1 Ephrin type-A receptor 2 transmembrane domain STE3 PF02076.15 CCM02147.1 - 0.019 14.2 0.2 0.026 13.8 0.2 1.1 1 0 0 1 1 1 0 Pheromone A receptor Amnionless PF14828.6 CCM02147.1 - 0.022 13.6 0.0 0.024 13.5 0.0 1.1 1 0 0 1 1 1 0 Amnionless TMEM52 PF14979.6 CCM02147.1 - 0.031 14.2 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Transmembrane 52 SIT PF15330.6 CCM02147.1 - 0.032 14.7 0.0 0.056 13.9 0.0 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Virul_fac_BrkB PF03631.15 CCM02147.1 - 0.042 13.5 0.8 0.054 13.1 0.8 1.1 1 0 0 1 1 1 0 Virulence factor BrkB 7TM_GPCR_Srz PF10325.9 CCM02147.1 - 0.042 13.2 0.0 0.05 12.9 0.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz CYYR1 PF10873.8 CCM02147.1 - 0.053 14.0 0.0 0.071 13.6 0.0 1.1 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 LapA_dom PF06305.11 CCM02147.1 - 0.053 13.3 0.9 0.11 12.3 0.9 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain TMIE PF16038.5 CCM02147.1 - 0.057 13.3 0.4 0.1 12.4 0.2 1.5 2 0 0 2 2 1 0 TMIE protein NicO PF03824.16 CCM02147.1 - 0.058 12.7 0.0 0.066 12.6 0.0 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein SID-1_RNA_chan PF13965.6 CCM02147.1 - 0.071 11.5 0.0 0.083 11.3 0.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 OSTbeta PF15048.6 CCM02147.1 - 0.094 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein Stevor PF17410.2 CCM02147.1 - 0.094 12.2 0.5 0.11 12.0 0.5 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Marek_A PF02124.15 CCM02147.1 - 0.099 12.5 0.9 0.19 11.5 0.9 1.4 1 0 0 1 1 1 0 Marek's disease glycoprotein A Orf78 PF06024.12 CCM02147.1 - 0.1 12.9 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) EMC3_TMCO1 PF01956.16 CCM02147.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like LYRIC PF15686.5 CCM02147.1 - 0.12 11.9 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF4448 PF14610.6 CCM02147.1 - 0.18 11.6 0.1 0.26 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF2207 PF09972.9 CCM02147.1 - 0.25 10.1 0.0 0.27 10.0 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) RCR PF12273.8 CCM02147.1 - 0.38 11.4 5.6 1.1 10.0 5.6 1.7 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red PMP1_2 PF08114.11 CCM02147.1 - 0.42 10.4 3.4 0.72 9.6 3.4 1.3 1 0 0 1 1 1 0 ATPase proteolipid family PRIMA1 PF16101.5 CCM02147.1 - 0.57 10.2 4.0 0.16 12.0 0.5 1.8 1 1 0 2 2 2 0 Proline-rich membrane anchor 1 HemY_N PF07219.13 CCM02147.1 - 1.1 9.5 5.1 0.13 12.5 0.9 1.7 2 0 0 2 2 1 0 HemY protein N-terminus CrgA PF06781.12 CCM02147.1 - 4.1 7.5 6.4 1.1 9.4 1.3 2.2 1 1 1 2 2 2 0 Cell division protein CrgA EAP30 PF04157.16 CCM02149.1 - 2.3e-68 230.0 0.0 2.6e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family DUF4423 PF14394.6 CCM02149.1 - 0.028 14.1 0.0 0.092 12.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) Pec_lyase_N PF04431.13 CCM02150.1 - 0.024 14.9 0.7 0.049 13.9 0.7 1.6 1 0 0 1 1 1 0 Pectate lyase, N terminus DUF2992 PF11208.8 CCM02150.1 - 0.29 11.4 0.2 0.29 11.4 0.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2992) DDHD PF02862.17 CCM02150.1 - 0.52 10.4 5.4 0.64 10.1 5.4 1.3 1 0 0 1 1 1 0 DDHD domain DUF4551 PF15087.6 CCM02150.1 - 4.3 6.0 14.2 5.3 5.7 14.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Macoilin PF09726.9 CCM02150.1 - 4.8 5.6 12.3 4.8 5.6 12.3 1.1 1 0 0 1 1 1 0 Macoilin family INCENP_ARK-bind PF03941.15 CCM02151.1 - 1.6e-21 76.0 1.8 1.2e-20 73.1 1.8 2.8 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region Sigma70_r1_2 PF00140.20 CCM02151.1 - 0.031 14.3 0.5 0.08 13.0 0.5 1.7 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 adh_short PF00106.25 CCM02152.1 - 4.4e-22 78.5 0.0 5.8e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM02152.1 - 5.5e-11 42.5 0.0 7e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM02152.1 - 2.7e-06 27.4 0.0 1.6e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 CCM02152.1 - 0.0035 16.5 0.0 0.0051 16.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCM02152.1 - 0.059 12.8 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM02152.1 - 0.095 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding DUF1776 PF08643.10 CCM02152.1 - 0.11 11.8 0.0 1.5 8.1 0.0 2.0 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) RNase_PH PF01138.21 CCM02154.1 - 2e-11 44.5 0.2 4.9e-11 43.2 0.2 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCM02154.1 - 0.026 14.5 0.0 0.25 11.4 0.0 2.3 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 HMG_box PF00505.19 CCM02155.1 - 3.2e-10 40.3 0.0 6.8e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM02155.1 - 0.033 14.8 0.0 0.08 13.5 0.0 1.7 1 0 0 1 1 1 0 HMG-box domain AMP-binding PF00501.28 CCM02157.1 - 3.1e-28 98.5 0.0 3.3e-27 95.2 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCM02157.1 - 5.7e-28 97.8 0.0 8.2e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCM02157.1 - 7.4e-10 38.7 0.0 1.4e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1778 PF08681.11 CCM02157.1 - 0.012 15.5 0.0 7 6.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1778) KR PF08659.10 CCM02157.1 - 0.016 15.2 0.2 0.031 14.2 0.2 1.5 1 0 0 1 1 1 0 KR domain PP-binding PF00550.25 CCM02157.1 - 0.039 14.3 0.1 0.26 11.7 0.1 2.2 1 1 0 1 1 1 0 Phosphopantetheine attachment site CbiX PF01903.17 CCM02157.1 - 0.096 13.0 0.0 8.9 6.7 0.0 2.8 2 0 0 2 2 2 0 CbiX ICMT PF04140.14 CCM02158.1 - 1e-12 48.3 0.1 7.9e-12 45.4 0.0 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM02158.1 - 1.3e-11 44.8 0.1 1.4e-10 41.5 0.2 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCM02158.1 - 4.4e-08 32.3 0.1 6.4e-08 31.8 0.1 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCM02158.1 - 0.041 13.4 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) ICMT PF04140.14 CCM02159.1 - 0.00018 21.8 0.0 0.00033 21.0 0.0 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM02159.1 - 0.057 13.8 0.0 0.091 13.2 0.0 1.3 1 0 0 1 1 1 0 Phospholipid methyltransferase DUF3188 PF11384.8 CCM02159.1 - 0.14 11.9 1.1 0.24 11.1 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) ICMT PF04140.14 CCM02160.1 - 2.8e-13 50.1 0.3 3.5e-12 46.6 0.1 2.4 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM02160.1 - 6.2e-10 39.4 1.2 3.7e-09 36.9 0.2 2.2 1 1 1 2 2 2 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCM02160.1 - 5.8e-07 28.6 0.2 8.4e-07 28.1 0.2 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family zinc_ribbon_10 PF10058.9 CCM02161.1 - 3.7e-19 68.2 0.2 2e-18 65.9 0.2 2.0 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein zf-RanBP PF00641.18 CCM02161.1 - 0.072 12.4 1.0 0.25 10.7 0.1 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Zn_Tnp_IS1595 PF12760.7 CCM02161.1 - 0.087 12.8 0.1 0.24 11.4 0.1 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain A2L_zn_ribbon PF08792.10 CCM02161.1 - 4.3 7.2 5.7 20 5.0 5.7 2.0 1 1 0 1 1 1 0 A2L zinc ribbon domain zf_C2H2_10 PF18414.1 CCM02161.1 - 4.3 6.9 4.8 0.69 9.5 0.6 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger Abhydrolase_6 PF12697.7 CCM02162.1 - 7.6e-13 49.6 5.4 1e-12 49.1 5.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM02162.1 - 4.4e-07 29.4 0.2 8.3e-07 28.5 0.2 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCM02162.1 - 5e-06 26.4 0.8 0.00014 21.6 0.4 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold WW PF00397.26 CCM02165.1 - 0.051 13.7 1.0 0.094 12.8 0.0 2.0 2 0 0 2 2 2 0 WW domain Mycobact_memb PF05423.13 CCM02166.1 - 0.086 12.8 1.4 0.2 11.5 0.3 2.0 2 0 0 2 2 2 0 Mycobacterium membrane protein Transket_pyr PF02779.24 CCM02167.1 - 4.9e-59 199.0 0.0 7.9e-59 198.3 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 CCM02167.1 - 6e-47 159.1 0.0 9.7e-47 158.5 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 CCM02167.1 - 5.2e-46 157.0 0.0 9.6e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component DEAD PF00270.29 CCM02168.1 - 3.1e-17 62.9 0.0 5.7e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCM02168.1 - 7.4e-11 42.3 0.0 2e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCM02168.1 - 2.8e-05 24.4 0.0 7.9e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3987 PF13148.6 CCM02168.1 - 1.7 7.5 6.9 0.047 12.7 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Aldo_ket_red PF00248.21 CCM02169.1 - 2.6e-39 135.2 0.0 1.5e-37 129.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family ICMT PF04140.14 CCM02170.1 - 1.4e-12 47.9 1.2 1.6e-12 47.6 0.1 1.7 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM02170.1 - 3.3e-12 46.7 0.8 4.7e-12 46.2 0.1 1.6 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 CCM02170.1 - 0.0016 18.0 0.0 0.0016 18.0 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCM02171.1 - 2.9e-13 50.0 0.1 2.3e-12 47.2 0.1 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM02171.1 - 6.1e-11 42.6 0.5 1.4e-10 41.5 0.5 1.8 1 1 0 1 1 1 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCM02171.1 - 6.1e-08 31.8 0.2 8.5e-08 31.4 0.2 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCM02171.1 - 2e-05 24.2 0.1 2.9e-05 23.7 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCM02172.1 - 1.5e-28 99.0 1.0 3.6e-13 49.8 0.0 3.2 4 0 0 4 4 4 2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM02172.1 - 1.6e-21 76.7 2.5 4.5e-10 39.9 0.1 2.7 2 1 0 2 2 2 2 Phospholipid methyltransferase DUF1295 PF06966.12 CCM02172.1 - 4.8e-12 45.9 0.3 5.4e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 CCM02172.1 - 6e-10 38.5 4.9 1.2e-07 30.9 0.3 2.2 2 0 0 2 2 2 2 Ergosterol biosynthesis ERG4/ERG24 family Steroid_dh PF02544.16 CCM02172.1 - 4.2e-06 26.8 0.1 0.056 13.4 0.0 2.7 2 1 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1335 PF07056.11 CCM02172.1 - 0.0025 17.9 0.0 0.45 10.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1335) DUF3188 PF11384.8 CCM02172.1 - 0.39 10.4 5.4 5.2 6.9 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) HAD PF12710.7 CCM02173.1 - 2.6e-18 67.1 0.0 4.9e-18 66.2 0.0 1.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 CCM02173.1 - 0.00039 20.0 0.0 0.00059 19.4 0.0 1.4 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 CCM02173.1 - 0.0013 18.2 0.0 0.0046 16.4 0.0 1.9 1 1 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.6 CCM02173.1 - 0.073 13.1 0.0 7.2 6.7 0.0 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCM02173.1 - 0.19 12.0 0.4 0.7 10.1 0.0 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Ribosomal_S13_N PF08069.12 CCM02174.1 - 2.3e-30 104.4 0.1 4.4e-30 103.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 CCM02174.1 - 4.4e-14 52.4 0.1 8.3e-14 51.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 Ribosomal_S6e PF01092.19 CCM02175.1 - 4.7e-59 197.8 0.0 9.2e-59 196.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e DUF5427 PF10310.9 CCM02176.1 - 2.3e-63 214.8 5.4 1e-59 202.8 0.0 2.2 1 1 1 2 2 2 2 Family of unknown function (DUF5427) Chromo PF00385.24 CCM02177.1 - 1.9e-06 27.7 2.4 7.3e-06 25.8 0.5 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain SPATA9 PF15824.5 CCM02177.1 - 0.38 10.0 1.8 0.65 9.2 1.0 1.8 2 0 0 2 2 2 0 Spermatogenesis-associated protein 9 Tim17 PF02466.19 CCM02178.1 - 6.4e-12 45.8 1.2 1.3e-11 44.9 0.7 1.7 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DUF5518 PF17647.1 CCM02178.1 - 0.079 13.1 2.6 5.8 7.1 0.1 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5518) Ras PF00071.22 CCM02179.1 - 1.3e-42 145.2 0.1 6.2e-36 123.4 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCM02179.1 - 1.2e-14 54.5 0.0 7.4e-09 35.9 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CCM02179.1 - 0.0075 15.8 0.0 0.022 14.3 0.0 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM02179.1 - 0.026 14.4 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Arf PF00025.21 CCM02179.1 - 0.13 11.7 0.1 0.41 10.1 0.1 1.7 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_25 PF13481.6 CCM02179.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3563 PF12086.8 CCM02180.1 - 0.045 13.5 0.0 0.076 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3563) Yippee-Mis18 PF03226.14 CCM02181.1 - 8.3e-16 58.1 0.2 9.1e-16 58.0 0.2 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PknG_rubred PF16919.5 CCM02181.1 - 0.079 13.1 0.0 0.086 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain RIG-I_C-RD PF11648.8 CCM02181.1 - 0.11 12.7 1.4 0.21 11.8 1.4 1.4 1 1 0 1 1 1 0 C-terminal domain of RIG-I Peptidase_C48 PF02902.19 CCM02182.1 - 8e-25 87.9 1.0 1.5e-24 87.1 1.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Use1 PF09753.9 CCM02183.1 - 0.12 12.0 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 YajC PF02699.15 CCM02183.1 - 0.52 10.2 2.6 0.52 10.2 0.7 1.8 2 0 0 2 2 2 0 Preprotein translocase subunit Sgf11 PF08209.11 CCM02185.1 - 5e-10 38.8 0.4 5e-10 38.8 0.4 1.9 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) CBS PF00571.28 CCM02186.1 - 1.5e-33 115.0 7.5 2.2e-08 34.4 0.1 5.8 5 0 0 5 5 5 5 CBS domain PB1 PF00564.24 CCM02186.1 - 8.4e-09 35.3 0.0 3e-08 33.5 0.0 2.0 1 1 0 1 1 1 1 PB1 domain Phage_HK97_TLTM PF06120.11 CCM02187.1 - 0.002 17.4 3.2 0.0038 16.5 0.8 2.0 1 1 1 2 2 2 1 Tail length tape measure protein Glyco_transf_64 PF09258.10 CCM02187.1 - 0.043 13.1 0.0 0.048 12.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 64 domain DUF1700 PF08006.11 CCM02187.1 - 3.5 7.1 8.4 4.3 6.8 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) UPF0121 PF03661.13 CCM02188.1 - 3.2e-45 154.4 4.6 3.5e-45 154.3 4.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DEAD PF00270.29 CCM02189.1 - 1e-33 116.6 0.0 5.5e-32 110.9 0.0 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM02189.1 - 1.2e-24 86.8 0.0 2.1e-23 82.8 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCM02189.1 - 5.3e-19 68.2 0.4 1.1e-18 67.1 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ERCC3_RAD25_C PF16203.5 CCM02189.1 - 0.00036 19.8 0.0 0.00067 18.9 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase PTH2 PF01981.16 CCM02190.1 - 6.3e-46 155.5 0.1 8.4e-46 155.1 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 PhzC-PhzF PF02567.16 CCM02190.1 - 0.092 12.2 0.3 0.28 10.6 0.3 1.6 1 1 1 2 2 2 0 Phenazine biosynthesis-like protein Mpv17_PMP22 PF04117.12 CCM02191.1 - 5.1e-21 74.7 0.1 5.1e-21 74.7 0.1 1.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family LGT PF01790.18 CCM02191.1 - 0.044 13.0 0.1 0.05 12.8 0.1 1.2 1 0 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase zf-Tim10_DDP PF02953.15 CCM02192.1 - 3.6e-12 45.8 0.1 2.8e-11 42.9 0.1 1.9 1 1 0 1 1 1 1 Tim10/DDP family zinc finger Bclx_interact PF08945.10 CCM02192.1 - 0.0072 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Bcl-x interacting, BH3 domain Beta_elim_lyase PF01212.21 CCM02193.1 - 1.7e-63 214.7 0.0 2.2e-63 214.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CCM02193.1 - 0.062 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CCM02193.1 - 0.069 11.7 0.0 0.1 11.1 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCM02193.1 - 0.084 11.8 0.1 0.15 11.0 0.1 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Urb2 PF10441.9 CCM02194.1 - 4.9e-41 140.9 0.3 4.9e-41 140.9 0.3 2.0 2 0 0 2 2 2 1 Urb2/Npa2 family RWD PF05773.22 CCM02196.1 - 4.5e-18 65.6 0.0 1e-17 64.5 0.0 1.6 1 0 0 1 1 1 1 RWD domain IBR PF01485.21 CCM02196.1 - 1.4e-14 54.0 20.1 6.3e-10 39.1 2.9 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 CCM02196.1 - 0.00012 22.0 7.5 0.00012 22.0 7.5 4.3 3 1 1 4 4 4 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCM02196.1 - 0.00017 21.9 7.8 0.00017 21.9 7.8 5.0 3 2 2 5 5 5 2 Ring finger domain zf-RING_5 PF14634.6 CCM02196.1 - 0.00099 19.0 7.6 0.00099 19.0 7.6 4.6 3 2 1 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCM02196.1 - 0.0079 16.0 9.3 0.0079 16.0 9.3 5.2 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM02196.1 - 0.0087 15.9 8.5 0.0087 15.9 8.5 5.9 5 1 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) KH_1 PF00013.29 CCM02197.1 - 8.1e-38 128.1 0.0 2.8e-09 36.7 0.0 7.9 7 1 0 7 7 7 6 KH domain Rhodanese PF00581.20 CCM02198.1 - 6.1e-12 46.0 0.0 2.1e-11 44.3 0.0 1.8 1 1 1 2 2 2 1 Rhodanese-like domain Multi_ubiq PF14452.6 CCM02198.1 - 0.012 15.8 0.0 0.039 14.2 0.0 1.9 2 0 0 2 2 2 0 Multiubiquitin Ctr PF04145.15 CCM02199.1 - 6.2e-30 104.8 0.1 8e-30 104.4 0.1 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF2093 PF09866.9 CCM02200.1 - 0.14 11.6 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2093) 3H PF02829.14 CCM02201.1 - 0.1 12.9 0.2 0.33 11.3 0.1 1.8 1 1 1 2 2 2 0 3H domain DUF572 PF04502.13 CCM02201.1 - 6.1 6.4 6.9 8.6 5.9 6.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Kinesin PF00225.23 CCM02202.1 - 2.7e-95 319.1 0.0 3.7e-95 318.6 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCM02202.1 - 7.9e-23 81.0 0.0 1.4e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Pox_A_type_inc PF04508.12 CCM02202.1 - 0.35 10.8 2.9 0.8 9.7 2.9 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Rhodanese PF00581.20 CCM02203.1 - 3.2e-14 53.3 0.0 3.3e-08 34.0 0.0 3.2 3 0 0 3 3 3 3 Rhodanese-like domain V-ATPase_C PF03223.15 CCM02204.1 - 7.9e-127 423.7 1.2 8.8e-127 423.5 1.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Frataxin_Cyay PF01491.16 CCM02205.1 - 1e-30 106.0 0.0 4.2e-19 68.6 0.0 2.0 2 0 0 2 2 2 2 Frataxin-like domain WD40 PF00400.32 CCM02207.1 - 3.2e-15 56.3 6.8 0.004 18.0 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CCM02207.1 - 1.7e-05 23.9 0.0 7.6e-05 21.8 0.0 2.0 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 CCM02207.1 - 0.0057 16.9 0.2 1.1 9.6 0.0 4.2 6 1 0 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCM02207.1 - 0.067 13.1 0.0 8.8 6.2 0.0 3.1 2 1 2 5 5 5 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 CCM02207.1 - 0.1 11.1 0.0 0.21 10.1 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain Bromodomain PF00439.25 CCM02208.1 - 1.3e-41 140.5 0.0 1.4e-21 76.4 0.0 2.6 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 CCM02208.1 - 5.2e-19 68.2 0.8 1.2e-18 67.0 0.8 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation AAA_13 PF13166.6 CCM02208.1 - 0.77 8.3 5.6 1.1 7.8 5.6 1.1 1 0 0 1 1 1 0 AAA domain CENP-Q PF13094.6 CCM02208.1 - 0.93 9.7 9.8 0.31 11.2 4.5 2.3 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Not3 PF04065.15 CCM02208.1 - 1.1 8.6 11.8 2.7 7.4 8.9 2.2 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component V_ATPase_I PF01496.19 CCM02208.1 - 1.5 6.7 2.4 2 6.2 2.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family G-patch PF01585.23 CCM02209.1 - 1.4e-09 37.7 0.1 2.7e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 G-patch domain zf-C2H2_jaz PF12171.8 CCM02209.1 - 1.2e-06 28.7 5.2 2e-06 27.9 5.2 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM02209.1 - 1.4e-05 25.3 1.0 2.4e-05 24.5 1.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Topoisom_I_N PF02919.15 CCM02209.1 - 0.0041 16.7 0.2 0.0064 16.0 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment G-patch_2 PF12656.7 CCM02209.1 - 0.0047 17.0 0.1 0.0047 17.0 0.1 2.6 2 0 0 2 2 2 1 G-patch domain zf-DBF PF07535.12 CCM02209.1 - 0.02 15.0 3.2 0.039 14.1 3.2 1.4 1 0 0 1 1 1 0 DBF zinc finger zf-C2H2_aberr PF17017.5 CCM02209.1 - 0.033 14.3 0.3 0.054 13.6 0.3 1.3 1 0 0 1 1 1 0 Aberrant zinc-finger zf-C2H2_2 PF12756.7 CCM02209.1 - 0.034 14.5 1.8 0.057 13.8 1.8 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) NusB PF01029.18 CCM02209.1 - 1.5 9.0 4.7 8.8 6.6 0.2 2.6 2 1 1 3 3 3 0 NusB family Helicase_C PF00271.31 CCM02210.1 - 4.3e-20 72.1 0.0 5.6e-19 68.5 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM02210.1 - 5.2e-19 68.9 0.0 1e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCM02210.1 - 1.7e-15 57.2 0.0 4.1e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_2 PF13639.6 CCM02211.1 - 0.00017 21.9 2.9 0.00031 21.0 2.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CCM02211.1 - 0.0065 16.2 2.1 0.016 14.9 2.1 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCM02211.1 - 0.0092 15.8 0.6 0.017 15.0 0.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM02211.1 - 0.041 13.8 2.3 0.077 12.9 2.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM02211.1 - 0.062 13.3 0.6 0.12 12.4 0.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Glucosamine_iso PF01182.20 CCM02212.1 - 7.9e-75 251.6 0.0 9e-75 251.4 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PXA PF02194.15 CCM02213.1 - 6.9e-45 153.3 0.6 1.2e-44 152.4 0.3 1.6 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 CCM02213.1 - 0.0033 18.0 0.0 0.012 16.2 0.0 1.9 1 1 1 2 2 2 1 Sorting nexin C terminal DUF3375 PF11855.8 CCM02213.1 - 0.21 10.4 0.0 0.38 9.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) PWI PF01480.17 CCM02215.1 - 6e-08 32.9 0.0 1.1e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 CCM02215.1 - 1.6e-05 24.7 5.9 2.9e-05 23.9 5.9 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_3 PF08777.11 CCM02215.1 - 0.0081 16.2 0.1 0.076 13.1 0.0 2.4 2 0 0 2 2 2 1 RNA binding motif zf_CCCH_4 PF18345.1 CCM02215.1 - 0.029 14.4 8.5 0.049 13.7 8.5 1.4 1 0 0 1 1 1 0 Zinc finger domain PSI_PsaE PF02427.17 CCM02215.1 - 0.045 13.4 0.1 4.7 7.0 0.0 2.3 2 0 0 2 2 2 0 Photosystem I reaction centre subunit IV / PsaE RRM_1 PF00076.22 CCM02215.1 - 0.19 11.6 0.2 1.4 8.8 0.0 2.5 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Melibiase_2 PF16499.5 CCM02216.1 - 1.3e-58 198.4 9.6 5e-58 196.5 9.6 1.9 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 CCM02216.1 - 2.6e-10 40.2 0.2 4.9e-10 39.3 0.2 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 CCM02216.1 - 2.2e-06 26.9 0.0 5e-06 25.7 0.0 1.5 2 0 0 2 2 2 1 Melibiase p450 PF00067.22 CCM02218.1 - 2.2e-63 214.6 0.0 2.7e-63 214.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M48 PF01435.18 CCM02219.1 - 1.2e-18 67.6 0.0 2e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 COX5B PF01215.19 CCM02220.1 - 5.7e-45 152.2 0.0 6.7e-45 151.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-CHCC PF10276.9 CCM02220.1 - 0.01 15.9 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger domain zf-C2H2_3 PF13878.6 CCM02220.1 - 0.099 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO A2L_zn_ribbon PF08792.10 CCM02220.1 - 0.18 11.6 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 A2L zinc ribbon domain Na_Ca_ex PF01699.24 CCM02221.1 - 1.2e-21 77.2 33.7 9.5e-17 61.4 16.6 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Complex1_LYR_2 PF13233.6 CCM02221.1 - 0.00065 20.4 0.0 0.0016 19.1 0.0 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 CCM02221.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Complex 1 protein (LYR family) L_HMGIC_fpl PF10242.9 CCM02221.1 - 9 6.5 11.3 7.7 6.7 2.1 2.5 2 0 0 2 2 2 0 Lipoma HMGIC fusion partner-like protein Cyanate_lyase PF02560.14 CCM02222.1 - 4e-34 116.3 0.1 1.1e-33 114.8 0.0 1.7 2 0 0 2 2 2 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 CCM02222.1 - 0.061 13.7 0.0 0.096 13.0 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain KorB PF08535.10 CCM02222.1 - 0.19 11.8 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 KorB domain DUF1479 PF07350.12 CCM02223.1 - 2.8e-115 385.4 0.1 6e-115 384.3 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1479) Tubulin PF00091.25 CCM02224.1 - 2e-61 207.6 0.0 2.9e-61 207.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCM02224.1 - 1.9e-37 128.2 0.0 2.9e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CCM02224.1 - 2.1e-05 24.8 0.0 5.9e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Transketolase_N PF00456.21 CCM02227.1 - 3.1e-15 56.0 0.3 2.7e-14 52.9 0.3 2.0 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transketolase_C PF02780.20 CCM02227.1 - 2.3e-08 34.0 0.0 5.2e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 CCM02227.1 - 3.7e-06 26.7 0.5 7e-06 25.8 0.1 1.6 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 CCM02227.1 - 0.0028 16.6 0.0 0.0047 15.9 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CCM02227.1 - 0.0054 16.5 0.0 0.02 14.7 0.0 1.9 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF4478 PF14793.6 CCM02227.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases DNA_pol_phi PF04931.13 CCM02228.1 - 4.4 5.3 4.8 6.1 4.8 4.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4112 PF13430.6 CCM02229.1 - 1.5e-22 79.8 0.1 2e-22 79.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) O-FucT PF10250.9 CCM02231.1 - 0.013 15.2 0.0 0.028 14.1 0.0 1.5 2 0 0 2 2 2 0 GDP-fucose protein O-fucosyltransferase DNApol_Exo PF18136.1 CCM02231.1 - 0.015 14.4 0.0 0.055 12.6 0.0 1.8 2 0 0 2 2 2 0 DNA mitochondrial polymerase exonuclease domain MFS_1 PF07690.16 CCM02233.1 - 3.2e-26 92.1 7.7 3.7e-26 91.9 7.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PUCC PF03209.15 CCM02233.1 - 0.081 11.9 8.3 0.17 10.9 8.4 1.5 1 1 0 1 1 1 0 PUCC protein MFS_1 PF07690.16 CCM02234.1 - 5.2e-30 104.5 26.9 1.9e-27 96.2 22.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LYRIC PF15686.5 CCM02234.1 - 0.022 14.4 0.3 0.04 13.5 0.3 1.5 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Asp PF00026.23 CCM02235.1 - 6.2e-76 255.8 10.5 7.6e-76 255.5 10.5 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM02235.1 - 8.6e-11 42.4 4.3 8.5e-07 29.4 0.4 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CCM02235.1 - 0.023 14.5 0.2 0.11 12.3 0.0 2.2 2 1 1 3 3 3 0 Xylanase inhibitor C-terminal Cu_bind_like PF02298.17 CCM02236.1 - 0.00052 20.0 0.9 0.0045 17.0 0.9 2.1 1 1 0 1 1 1 1 Plastocyanin-like domain MGC-24 PF05283.11 CCM02236.1 - 1.7 9.1 9.4 0.45 10.9 5.8 1.7 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin A_deaminase PF00962.22 CCM02237.1 - 1.8e-27 96.6 0.0 1.7e-26 93.4 0.0 2.0 2 0 0 2 2 2 1 Adenosine/AMP deaminase HSCB_C PF07743.13 CCM02238.1 - 0.24 11.9 0.1 0.24 11.9 0.1 2.9 3 1 0 3 3 3 0 HSCB C-terminal oligomerisation domain p450 PF00067.22 CCM02239.1 - 1.1e-63 215.6 0.0 1.6e-63 215.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GST_C_6 PF17171.4 CCM02240.1 - 4.9e-14 51.9 0.0 1.2e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CCM02240.1 - 0.00072 20.3 0.0 0.0012 19.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain SAM35 PF10806.8 CCM02240.1 - 0.18 12.1 0.1 0.41 10.9 0.1 1.5 1 1 0 1 1 1 0 SAM35, subunit of SAM coomplex Vps54_N PF10475.9 CCM02241.1 - 0.15 11.3 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Mito_carr PF00153.27 CCM02242.1 - 1.1e-29 102.2 5.4 1.9e-17 62.9 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Trp_halogenase PF04820.14 CCM02243.1 - 4.9e-13 48.7 0.0 7.3e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Tryptophan halogenase FAD_binding_3 PF01494.19 CCM02243.1 - 6.1e-05 22.4 0.0 0.00013 21.3 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain p450 PF00067.22 CCM02244.1 - 6.3e-61 206.5 0.0 6.7e-59 199.8 0.0 2.2 1 1 0 1 1 1 1 Cytochrome P450 GYF_2 PF14237.6 CCM02245.1 - 0.04 13.7 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 GYF domain 2 MFS_1 PF07690.16 CCM02246.1 - 4.9e-42 144.1 66.3 4.9e-42 144.1 66.3 2.9 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCM02246.1 - 0.011 15.5 1.7 0.011 15.5 1.7 4.2 3 2 1 4 4 4 0 Ion channel regulatory protein UNC-93 ketoacyl-synt PF00109.26 CCM02247.1 - 3.1e-50 171.1 0.2 6.5e-50 170.1 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCM02247.1 - 2.3e-42 145.6 0.0 4.3e-42 144.7 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CCM02247.1 - 6.9e-31 107.5 1.2 1.4e-28 100.0 0.3 2.5 2 0 0 2 2 2 2 KR domain NAD_binding_4 PF07993.12 CCM02247.1 - 7.7e-31 107.2 0.0 1.3e-30 106.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 CCM02247.1 - 2.2e-29 101.9 0.0 5.3e-29 100.6 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCM02247.1 - 2.8e-29 102.3 0.0 8.1e-29 100.8 0.0 1.8 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCM02247.1 - 6.9e-12 45.8 0.0 1.7e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 CCM02247.1 - 3.4e-07 30.0 0.0 2e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM02247.1 - 3.3e-05 24.2 0.2 0.00058 20.2 0.2 2.7 2 0 0 2 2 2 1 Phosphopantetheine attachment site adh_short PF00106.25 CCM02247.1 - 0.00069 19.1 0.0 0.066 12.7 0.0 3.0 3 0 0 3 3 3 1 short chain dehydrogenase 3Beta_HSD PF01073.19 CCM02247.1 - 0.0017 17.4 0.0 0.008 15.2 0.0 2.0 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 CCM02247.1 - 0.0079 15.6 0.5 0.019 14.4 0.5 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCM02247.1 - 0.011 15.6 0.6 0.028 14.2 0.6 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Phage_holin_7_1 PF16081.5 CCM02247.1 - 0.078 13.2 0.7 3.3 7.9 0.0 2.5 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Colicin_K PF17500.2 CCM02248.1 - 0.03 14.9 2.6 0.03 14.9 2.6 2.1 2 0 0 2 2 2 0 Colicin-K YitT_membrane PF02588.15 CCM02248.1 - 0.37 10.1 12.7 0.065 12.6 6.9 2.1 2 0 0 2 2 2 0 Uncharacterised 5xTM membrane BCR, YitT family COG1284 adh_short PF00106.25 CCM02249.1 - 7e-21 74.6 0.1 1.7e-20 73.3 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM02249.1 - 1.3e-17 64.2 0.1 2.8e-17 63.0 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase AAA PF00004.29 CCM02250.1 - 3.4e-14 53.4 0.0 6.4e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM02250.1 - 2.7e-10 40.9 0.1 3.6e-09 37.2 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain BAH PF01426.18 CCM02250.1 - 4.8e-07 29.7 0.0 9.6e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 BAH domain AAA_22 PF13401.6 CCM02250.1 - 6.6e-07 29.7 0.0 4.4e-06 27.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_lid_10 PF17872.1 CCM02250.1 - 2.6e-05 24.3 0.0 6.7e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain DUF2075 PF09848.9 CCM02250.1 - 0.00041 19.7 0.0 0.00071 18.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 CCM02250.1 - 0.0016 18.8 0.0 0.0042 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CCM02250.1 - 0.024 14.5 0.0 0.14 12.1 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 CCM02250.1 - 0.031 14.0 1.9 0.061 13.1 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 CCM02250.1 - 0.062 13.0 0.1 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCM02250.1 - 0.11 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 CCM02250.1 - 0.16 11.8 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 NTPase DHBP_synthase PF00926.19 CCM02251.1 - 2.6e-84 281.5 0.0 3.1e-84 281.3 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Homeodomain PF00046.29 CCM02253.1 - 1.2e-15 57.1 4.9 2.1e-15 56.3 4.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCM02253.1 - 0.0021 17.9 0.1 0.0043 16.9 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain YkpC PF17447.2 CCM02253.1 - 3.5 8.7 5.3 0.37 11.7 0.5 2.1 2 0 0 2 2 2 0 Uncharacterized YkpC-like Methyltransf_16 PF10294.9 CCM02254.1 - 2.4e-16 60.0 0.0 3.9e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 CCM02254.1 - 6.3e-05 22.8 0.0 0.00018 21.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM02254.1 - 0.00051 20.7 0.0 0.0011 19.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM02254.1 - 0.00081 20.1 0.0 0.0033 18.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CCM02254.1 - 0.0035 16.8 0.0 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 CCM02254.1 - 0.0062 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCM02254.1 - 0.033 14.0 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF938 PF06080.12 CCM02254.1 - 0.19 11.5 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ribosomal_L2_C PF03947.18 CCM02256.1 - 8.6e-55 184.3 0.9 1.5e-54 183.5 0.9 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CCM02256.1 - 7.2e-24 83.5 0.1 1.8e-23 82.3 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain TIP49 PF06068.13 CCM02257.1 - 2.4e-157 523.7 0.4 3.1e-157 523.3 0.4 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CCM02257.1 - 1.4e-19 69.9 0.8 1.1e-18 67.2 1.1 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 CCM02257.1 - 2.9e-09 37.5 1.1 1.5e-05 25.4 0.1 3.5 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCM02257.1 - 3.9e-06 26.7 0.3 0.004 16.9 0.1 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 CCM02257.1 - 1.2e-05 24.7 0.8 2.5e-05 23.8 0.8 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 CCM02257.1 - 0.0005 20.5 0.2 0.0026 18.2 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 CCM02257.1 - 0.004 16.6 6.6 0.074 12.4 0.5 3.6 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CCM02257.1 - 0.016 15.5 0.1 0.79 10.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCM02257.1 - 0.018 14.6 0.4 0.067 12.8 0.2 2.0 1 1 1 2 2 2 0 AAA domain AAA_19 PF13245.6 CCM02257.1 - 0.022 15.1 4.9 0.76 10.1 1.9 3.4 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CCM02257.1 - 0.045 13.7 2.8 8.9 6.3 0.0 3.6 3 2 1 4 4 4 0 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCM02257.1 - 0.12 12.5 1.3 3.2 7.8 0.0 3.4 4 1 0 4 4 4 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CCM02257.1 - 0.18 12.0 0.7 2.9 8.1 0.1 2.6 2 1 0 2 2 2 0 AAA domain DUF2271 PF10029.9 CCM02258.1 - 0.037 13.7 0.2 0.081 12.6 0.2 1.6 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) Ribosomal_L21e PF01157.18 CCM02259.1 - 3.9e-45 151.8 4.3 1.2e-44 150.3 3.2 1.9 2 0 0 2 2 2 1 Ribosomal protein L21e RNA_replicase_B PF03431.13 CCM02259.1 - 0.0088 14.6 0.4 0.0098 14.4 0.4 1.0 1 0 0 1 1 1 1 RNA replicase, beta-chain S4 PF01479.25 CCM02260.1 - 3.7e-12 45.8 1.0 3.7e-12 45.8 1.0 2.8 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 CCM02260.1 - 1.7e-05 25.6 0.0 4.1e-05 24.4 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Aldo_ket_red PF00248.21 CCM02261.1 - 2.2e-73 247.1 0.0 2.8e-73 246.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3140 PF11338.8 CCM02262.1 - 3.6e-25 88.2 0.6 3.6e-25 88.2 0.6 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3140) BORG_CEP PF14957.6 CCM02262.1 - 7.8 7.7 11.8 0.78 10.9 6.3 1.9 1 1 1 2 2 2 0 Cdc42 effector Chitin_synth_2 PF03142.15 CCM02263.1 - 4.8e-278 923.0 0.2 6.3e-278 922.6 0.2 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 CCM02263.1 - 8.3e-11 42.2 0.1 2.1e-10 40.8 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCM02263.1 - 1.5e-09 38.1 0.0 1.4e-08 34.9 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCM02263.1 - 0.0028 17.5 0.0 0.03 14.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CCM02263.1 - 0.073 12.5 0.0 0.34 10.4 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 21 GspL_C PF12693.7 CCM02263.1 - 4.1 7.2 6.3 13 5.6 6.3 1.8 1 0 0 1 1 1 0 GspL periplasmic domain Raptor_N PF14538.6 CCM02264.1 - 2.4e-59 199.5 0.0 5.7e-59 198.3 0.0 1.6 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain zf-C2H2 PF00096.26 CCM02264.1 - 7.4e-09 35.6 4.7 0.0011 19.3 0.7 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM02264.1 - 2.9e-07 30.8 2.5 0.0012 19.5 0.5 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger WD40 PF00400.32 CCM02264.1 - 1.6e-06 28.7 6.9 0.077 13.9 0.8 6.2 6 0 0 6 6 5 1 WD domain, G-beta repeat HEAT PF02985.22 CCM02264.1 - 3e-05 23.9 2.7 0.00031 20.8 0.0 3.8 6 0 0 6 6 3 1 HEAT repeat zf-C2H2_jaz PF12171.8 CCM02264.1 - 7.5e-05 22.9 0.8 0.36 11.2 0.2 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding HEAT_2 PF13646.6 CCM02264.1 - 0.00013 22.3 0.0 0.0009 19.6 0.0 2.6 1 1 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.6 CCM02264.1 - 0.00037 20.9 0.0 0.0022 18.5 0.0 2.4 1 0 0 1 1 1 1 HEAT-like repeat ANAPC4_WD40 PF12894.7 CCM02264.1 - 0.0011 19.2 0.1 7.8 6.9 0.0 4.0 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Cnd1 PF12717.7 CCM02264.1 - 0.0011 19.0 0.0 0.0071 16.4 0.0 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 zf-C2H2_6 PF13912.6 CCM02264.1 - 0.0012 18.8 0.4 0.0079 16.2 0.1 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 CCM02264.1 - 0.033 14.6 0.2 4.4 7.8 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Arm PF00514.23 CCM02264.1 - 0.077 13.1 0.0 2.6 8.2 0.0 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Peptidase_C14 PF00656.22 CCM02264.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Caspase domain zf-H2C2_2 PF13465.6 CCM02264.1 - 4.4 7.9 9.5 0.45 11.0 0.3 3.3 3 0 0 3 3 3 0 Zinc-finger double domain PfkB PF00294.24 CCM02265.1 - 3e-66 223.8 0.2 3.7e-66 223.5 0.2 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase TGBp3 PF02495.17 CCM02265.1 - 0.066 12.9 0.0 14 5.4 0.0 2.6 2 0 0 2 2 2 0 Triple gene block 3 Ribosomal_S19 PF00203.21 CCM02266.1 - 1.1e-26 92.5 0.0 1.4e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 CNOT11 PF10155.9 CCM02268.1 - 6.5e-18 65.1 0.0 1.4e-17 64.0 0.0 1.6 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 11 SNAPc_SNAP43 PF09808.9 CCM02268.1 - 0.086 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 PRR20 PF15708.5 CCM02271.1 - 1.5 8.7 8.7 1.9 8.3 8.1 1.5 1 1 0 1 1 1 0 Proline-rich protein family 20 STE3 PF02076.15 CCM02272.1 - 4.5e-111 370.7 17.0 5.4e-111 370.4 17.0 1.1 1 0 0 1 1 1 1 Pheromone A receptor SKG6 PF08693.10 CCM02272.1 - 6.6 6.2 11.2 2.2 7.8 1.4 3.4 3 0 0 3 3 3 0 Transmembrane alpha-helix domain STE3 PF02076.15 CCM02274.1 - 1.2e-110 369.3 25.6 1.4e-110 369.1 25.6 1.0 1 0 0 1 1 1 1 Pheromone A receptor DUF3817 PF12823.7 CCM02274.1 - 1 10.2 10.4 0.63 10.9 1.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF3817) STE3 PF02076.15 CCM02275.1 - 5.3e-92 308.1 24.8 6.4e-92 307.8 24.8 1.1 1 0 0 1 1 1 1 Pheromone A receptor STE3 PF02076.15 CCM02276.1 - 2e-70 237.3 7.0 2.5e-70 237.0 7.0 1.0 1 0 0 1 1 1 1 Pheromone A receptor Pheromone PF08015.11 CCM02277.1 - 5.3e-05 24.2 0.7 0.051 14.6 0.1 2.4 2 1 0 2 2 2 2 Fungal mating-type pheromone STE3 PF02076.15 CCM02279.1 - 1.3e-35 123.0 12.8 2e-35 122.4 12.8 1.1 1 0 0 1 1 1 1 Pheromone A receptor STE3 PF02076.15 CCM02280.1 - 2.9e-96 322.1 26.3 3.4e-96 321.9 26.3 1.0 1 0 0 1 1 1 1 Pheromone A receptor SGL PF08450.12 CCM02281.1 - 7.6e-26 91.2 0.0 1.2e-25 90.5 0.0 1.3 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 CCM02281.1 - 0.00012 22.2 0.0 0.00042 20.4 0.0 2.0 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 CCM02281.1 - 0.018 15.3 0.0 0.044 14.0 0.0 1.8 1 0 0 1 1 1 0 Arylesterase PD40 PF07676.12 CCM02281.1 - 0.025 14.5 0.1 6.4 6.8 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Myb_DNA-binding PF00249.31 CCM02282.1 - 9.5e-18 64.1 0.3 1.1e-09 38.3 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCM02282.1 - 3.1e-13 49.7 0.2 4.7e-05 23.5 0.0 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain SLIDE PF09111.10 CCM02282.1 - 5.5e-07 29.6 0.2 0.0041 17.1 0.0 2.3 2 0 0 2 2 2 2 SLIDE SANT_DAMP1_like PF16282.5 CCM02282.1 - 0.061 13.5 0.8 0.12 12.6 0.2 1.7 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 PCI PF01399.27 CCM02283.1 - 1.7e-09 38.1 0.0 4.4e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 PCI domain Prefoldin PF02996.17 CCM02284.1 - 1.7e-27 95.7 0.3 3.2e-26 91.6 0.3 2.1 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 CCM02284.1 - 0.0025 17.7 0.6 0.026 14.5 0.1 2.3 2 1 0 2 2 2 1 Prefoldin subunit End3 PF12761.7 CCM02284.1 - 0.023 14.9 0.5 0.089 13.0 0.0 2.0 1 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Rx_N PF18052.1 CCM02284.1 - 0.032 14.5 1.3 6 7.2 0.1 2.5 2 0 0 2 2 2 0 Rx N-terminal domain Lipase_GDSL_2 PF13472.6 CCM02284.1 - 0.14 12.6 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family SNF2_N PF00176.23 CCM02285.1 - 6.5e-48 163.2 0.0 1.5e-47 162.0 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4 PF00097.25 CCM02285.1 - 3.5e-06 26.8 1.7 7.9e-06 25.7 1.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCM02285.1 - 3.9e-06 26.6 2.0 7.8e-06 25.6 2.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCM02285.1 - 2.8e-05 24.1 2.1 7.3e-05 22.7 2.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCM02285.1 - 3.9e-05 23.4 4.4 7.8e-05 22.5 4.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM02285.1 - 0.0001 22.1 4.6 0.00023 20.9 4.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCM02285.1 - 0.00022 21.5 5.2 0.00055 20.2 5.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCM02285.1 - 0.00037 20.4 5.6 0.00083 19.3 5.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CCM02285.1 - 0.019 14.6 2.8 0.032 13.8 1.5 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF3461 PF11944.8 CCM02285.1 - 0.11 12.6 0.2 0.81 9.8 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3461) zf-C3HC4_4 PF15227.6 CCM02285.1 - 0.24 11.6 1.7 0.59 10.3 1.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-nanos PF05741.13 CCM02286.1 - 0.084 13.1 1.6 1.1 9.6 0.0 2.6 2 1 0 2 2 2 0 Nanos RNA binding domain zf-Di19 PF05605.12 CCM02286.1 - 0.31 11.4 6.5 7.2 7.0 1.4 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding RdRP PF05183.12 CCM02288.1 - 1.3e-100 337.8 0.0 2.3e-100 336.9 0.0 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase CIA30 PF08547.12 CCM02288.1 - 3.9e-21 75.7 0.0 6.4e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Ras PF00071.22 CCM02289.1 - 4.7e-57 192.1 0.1 5.4e-57 191.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM02289.1 - 5.4e-19 68.6 0.0 8.4e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM02289.1 - 1.5e-07 31.1 0.0 1.7e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCM02289.1 - 3.1e-05 23.9 0.0 0.06 13.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CCM02289.1 - 0.00017 21.2 0.0 0.00039 20.0 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CCM02289.1 - 0.0033 17.0 0.1 0.011 15.2 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 CCM02289.1 - 0.005 16.9 0.0 0.0082 16.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ser_hydrolase PF06821.13 CCM02289.1 - 0.063 13.1 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase ATP_bind_1 PF03029.17 CCM02289.1 - 0.33 10.7 1.8 2.9 7.6 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Git3 PF11710.8 CCM02290.1 - 0.11 12.3 7.8 0.88 9.3 7.8 2.1 1 1 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 Pyr_redox_2 PF07992.14 CCM02291.1 - 1e-44 153.0 2.4 1.4e-44 152.5 2.4 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase IMS PF00817.20 CCM02291.1 - 9.1e-40 136.1 0.0 2.1e-39 134.9 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family Rieske PF00355.26 CCM02291.1 - 1.6e-17 63.3 0.1 3.2e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain IMS_C PF11799.8 CCM02291.1 - 3.9e-16 59.8 0.0 1e-15 58.4 0.0 1.8 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Pyr_redox PF00070.27 CCM02291.1 - 1.1e-06 29.0 5.8 3.5e-06 27.5 0.6 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase zf_UBZ PF18439.1 CCM02291.1 - 1.6e-06 27.6 2.5 0.0063 16.1 0.9 2.5 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger Reductase_C PF14759.6 CCM02291.1 - 7.2e-06 26.5 0.0 2.3e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 Reductase C-terminal K_oxygenase PF13434.6 CCM02291.1 - 0.00085 18.6 0.1 0.29 10.2 0.0 3.0 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) IMS_HHH PF11798.8 CCM02291.1 - 0.083 13.3 0.1 0.28 11.6 0.0 2.0 2 0 0 2 2 2 0 IMS family HHH motif SAD_SRA PF02182.17 CCM02292.1 - 2.2e-54 183.4 0.1 3e-54 183.0 0.1 1.2 1 0 0 1 1 1 1 SAD/SRA domain Hva1_TUDOR PF11160.8 CCM02293.1 - 3e-14 52.9 0.6 4.6e-14 52.3 0.6 1.3 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain F-box_4 PF15966.5 CCM02294.1 - 0.013 15.4 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 F-box F-box-like PF12937.7 CCM02294.1 - 0.023 14.6 0.1 0.064 13.2 0.1 1.8 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 CCM02294.1 - 0.079 12.9 0.4 0.2 11.6 0.4 1.7 1 0 0 1 1 1 0 F-box domain Na_sulph_symp PF00939.19 CCM02295.1 - 1.2e-29 103.7 21.4 1.5e-29 103.4 21.4 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CCM02295.1 - 3.1e-27 95.6 37.0 4.2e-19 68.9 13.7 2.2 1 1 1 2 2 2 2 Citrate transporter ArsB PF02040.15 CCM02295.1 - 0.00065 19.1 5.8 0.0012 18.3 5.8 1.4 1 1 0 1 1 1 1 Arsenical pump membrane protein BetaGal_dom4_5 PF13364.6 CCM02296.1 - 1.8e-53 180.0 7.2 5.4e-32 110.8 0.5 3.2 2 1 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 CCM02296.1 - 6.1e-34 117.4 0.8 1.4e-33 116.3 0.8 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 CCM02296.1 - 2.7e-22 78.1 1.0 2.1e-21 75.3 0.3 2.8 3 0 0 3 3 3 1 Beta-galactosidase, domain 3 BTB PF00651.31 CCM02297.1 - 0.0076 16.5 0.0 0.64 10.3 0.0 2.8 2 1 0 2 2 2 2 BTB/POZ domain Glyco_hydro_15 PF00723.21 CCM02298.1 - 3.1e-51 174.6 0.0 1.1e-50 172.8 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 Complex1_51K PF01512.17 CCM02299.1 - 4.4e-48 163.0 0.0 6.8e-48 162.4 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CCM02299.1 - 5e-32 109.8 1.3 8.3e-32 109.1 0.2 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CCM02299.1 - 7.3e-09 35.4 0.0 1.8e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 SLBB domain DUF3568 PF12092.8 CCM02299.1 - 0.1 12.7 0.5 0.19 11.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) Glyco_hydro_2 PF00703.21 CCM02300.1 - 7.4e-06 26.6 0.0 1.7e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Aldedh PF00171.22 CCM02302.1 - 1.4e-75 254.6 0.0 4.2e-72 243.1 0.0 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family COesterase PF00135.28 CCM02303.1 - 1.2e-81 275.2 3.0 2.2e-80 271.0 3.0 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM02303.1 - 2.7e-11 43.7 0.0 2.4e-10 40.6 0.0 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM02303.1 - 0.0018 17.8 0.1 0.0032 17.0 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family VirB3 PF05101.13 CCM02304.1 - 0.45 10.8 5.3 9.5 6.5 5.3 2.0 1 1 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein HET PF06985.11 CCM02305.1 - 1.2e-13 51.6 2.1 6.7e-12 46.0 0.0 2.2 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Peptidase_M16_M PF16187.5 CCM02306.1 - 3.2e-87 292.4 0.0 5.2e-87 291.7 0.0 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 CCM02306.1 - 5.6e-27 94.6 0.0 1.1e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCM02306.1 - 4.9e-21 75.6 0.0 1e-08 35.4 0.0 3.4 4 0 0 4 4 4 2 Peptidase M16 inactive domain RicinB_lectin_2 PF14200.6 CCM02307.1 - 0.021 15.6 0.0 0.31 11.8 0.0 2.6 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Phage_Mu_Gam PF07352.12 CCM02307.1 - 0.023 14.6 5.9 1.8 8.5 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein DUF3005 PF11448.8 CCM02307.1 - 0.099 12.7 0.2 0.2 11.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) TBCC_N PF16752.5 CCM02307.1 - 0.35 11.3 4.4 4.8 7.6 0.1 2.2 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain PRKG1_interact PF15898.5 CCM02307.1 - 0.61 11.0 5.8 5.5 8.0 1.0 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Ribosomal_60s PF00428.19 CCM02309.1 - 1.4e-27 96.1 11.4 1.8e-27 95.7 11.4 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.7 CCM02309.1 - 2.9 8.6 9.4 0.29 11.8 5.1 1.4 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Kelch_5 PF13854.6 CCM02310.1 - 9.8e-21 73.3 4.5 1.1e-06 28.5 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 CCM02310.1 - 2.3e-17 62.7 7.1 1.6e-06 28.0 0.2 6.6 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CCM02310.1 - 1.8e-12 47.2 19.9 1.2e-08 35.0 0.2 7.2 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_1 PF01344.25 CCM02310.1 - 7.8e-10 38.2 8.6 1.4e-07 30.9 0.3 5.6 6 0 0 6 6 6 1 Kelch motif Kelch_2 PF07646.15 CCM02310.1 - 0.00029 20.7 6.6 0.00054 19.8 0.5 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 CCM02310.1 - 0.00077 19.7 11.1 0.036 14.4 0.2 5.8 7 0 0 7 7 7 1 Kelch motif Prefoldin_2 PF01920.20 CCM02311.1 - 6.8e-22 77.4 3.5 8.3e-22 77.2 3.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit TMF_DNA_bd PF12329.8 CCM02311.1 - 0.0014 18.5 6.0 0.014 15.4 0.2 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Prefoldin PF02996.17 CCM02311.1 - 0.0039 17.1 4.1 0.34 10.8 0.2 2.1 1 1 1 2 2 2 2 Prefoldin subunit MscS_porin PF12795.7 CCM02311.1 - 0.017 14.7 2.0 1.7 8.2 0.1 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF5082 PF16888.5 CCM02311.1 - 0.023 15.0 3.7 0.092 13.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) ABC_tran_CTD PF16326.5 CCM02311.1 - 0.03 14.6 9.6 0.9 9.8 0.2 2.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain PCRF PF03462.18 CCM02311.1 - 0.065 13.1 5.5 0.12 12.3 5.4 1.4 1 1 0 1 1 1 0 PCRF domain MIF4G_like_2 PF09090.11 CCM02311.1 - 0.072 12.6 1.6 0.087 12.3 1.6 1.1 1 0 0 1 1 1 0 MIF4G like V_ATPase_I PF01496.19 CCM02311.1 - 0.078 10.9 2.3 0.1 10.5 2.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.12 CCM02311.1 - 0.082 12.9 0.8 5.7 7.0 0.2 2.1 2 0 0 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 CCM02311.1 - 0.13 12.6 5.9 0.34 11.3 2.1 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FTA4 PF13093.6 CCM02311.1 - 0.16 11.9 3.2 0.2 11.5 3.2 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 XhlA PF10779.9 CCM02311.1 - 0.28 11.4 5.0 2.2 8.6 0.7 2.3 2 0 0 2 2 2 0 Haemolysin XhlA DASH_Dam1 PF08653.10 CCM02311.1 - 0.28 11.0 1.4 5.7 6.8 0.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 Spc24 PF08286.11 CCM02311.1 - 0.34 11.2 6.6 2.9 8.2 0.3 2.3 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 Shugoshin_N PF07558.11 CCM02311.1 - 0.5 10.3 3.1 0.29 11.0 0.6 1.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Plk4_PB2 PF18409.1 CCM02311.1 - 0.65 10.7 2.9 29 5.4 2.9 2.2 1 1 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 FlaC_arch PF05377.11 CCM02311.1 - 0.66 10.4 6.1 5.8 7.4 1.0 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3958 PF13125.6 CCM02311.1 - 0.91 9.8 9.4 2.2 8.5 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) DUF4140 PF13600.6 CCM02311.1 - 1.1 9.8 5.2 5.2 7.6 1.0 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) UPF0449 PF15136.6 CCM02311.1 - 3 8.4 8.7 3 8.4 1.9 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 RasGAP PF00616.19 CCM02314.1 - 1.2e-24 87.2 0.2 2.2e-15 57.0 0.2 3.7 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase MOR2-PAG1_C PF14225.6 CCM02314.1 - 6.9e-06 26.1 2.4 1.7e-05 24.8 0.3 2.8 3 0 0 3 3 3 1 Cell morphogenesis C-terminal CRAL_TRIO_2 PF13716.6 CCM02314.1 - 0.00013 22.1 0.1 0.00043 20.5 0.1 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain 3-PAP PF12578.8 CCM02314.1 - 0.034 13.9 0.1 0.079 12.7 0.1 1.6 1 0 0 1 1 1 0 Myotubularin-associated protein Abhydrolase_2 PF02230.16 CCM02315.1 - 9e-41 140.0 0.0 2e-40 138.9 0.0 1.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 CCM02315.1 - 0.00017 21.3 0.0 0.00022 20.9 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 CCM02315.1 - 0.00017 21.2 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CCM02315.1 - 0.00065 19.0 0.2 0.27 10.5 0.1 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 CCM02315.1 - 0.0012 18.6 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 CCM02315.1 - 0.0016 19.1 0.0 0.0017 19.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CCM02315.1 - 0.004 16.7 0.0 0.69 9.3 0.0 2.1 1 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCM02315.1 - 0.0058 16.5 0.0 0.0068 16.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CCM02315.1 - 0.0075 15.9 0.2 0.03 14.0 0.2 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CCM02315.1 - 0.018 14.8 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 CCM02315.1 - 0.22 11.5 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Cutinase Isochorismatase PF00857.20 CCM02317.1 - 6.9e-38 130.6 0.0 9e-38 130.2 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family RRP7 PF12923.7 CCM02318.1 - 6.3e-33 113.4 5.6 6.3e-33 113.4 5.6 1.6 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 CCM02318.1 - 7.8e-09 35.5 0.0 2e-07 31.0 0.0 2.7 3 0 0 3 3 3 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 CCM02318.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_46 PF01374.18 CCM02318.1 - 0.037 13.6 1.5 0.065 12.8 1.5 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 GRAM PF02893.20 CCM02319.1 - 0.019 14.9 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 GRAM domain Vps36_ESCRT-II PF11605.8 CCM02319.1 - 0.032 14.4 0.0 0.058 13.6 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 Gpr1_Fun34_YaaH PF01184.19 CCM02320.1 - 6.5e-54 182.7 14.0 8e-54 182.4 14.0 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 CCM02321.1 - 1.3e-51 175.2 14.5 1.7e-51 174.8 14.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Pkinase PF00069.25 CCM02322.1 - 1.4e-40 139.3 0.0 7.1e-24 84.6 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02322.1 - 4.4e-12 45.8 0.0 3.2e-09 36.4 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CCM02322.1 - 0.0003 20.8 0.6 0.0007 19.6 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 CCM02322.1 - 0.022 14.4 0.0 0.051 13.2 0.0 1.6 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 PI-TkoII_IV PF18714.1 CCM02322.1 - 0.18 11.3 0.0 0.41 10.1 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV UCH PF00443.29 CCM02323.1 - 1.4e-29 103.4 0.0 2.3e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM02323.1 - 0.016 14.8 0.1 0.068 12.8 0.1 2.1 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DUF1992 PF09350.10 CCM02325.1 - 3.3e-21 75.2 0.4 1.2e-20 73.4 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) BRD4_CDT PF17105.5 CCM02325.1 - 0.11 12.1 3.8 0.33 10.6 3.8 1.9 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 Aldedh PF00171.22 CCM02326.1 - 1.4e-104 350.2 0.0 1.7e-104 349.9 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Cellulase PF00150.18 CCM02327.1 - 7.5e-48 163.4 0.3 9.9e-48 163.0 0.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 CCM02327.1 - 8.2e-13 48.1 10.3 8.2e-13 48.1 10.3 2.7 3 0 0 3 3 3 1 Fungal cellulose binding domain BTB PF00651.31 CCM02328.1 - 6.7e-14 52.1 0.0 1.7e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Pro_isomerase PF00160.21 CCM02329.1 - 1.1e-38 133.0 0.0 1.7e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 CCM02329.1 - 2.1e-15 56.3 0.0 3.6e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RhoGEF PF00621.20 CCM02330.1 - 2.2e-17 63.9 0.0 5.6e-08 33.2 0.2 3.2 3 0 0 3 3 3 3 RhoGEF domain LRR_4 PF12799.7 CCM02331.1 - 1.9e-12 47.2 12.2 0.00031 21.1 0.4 7.9 5 2 2 9 9 9 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCM02331.1 - 1.5e-09 37.2 10.3 1.1 9.5 0.0 7.7 9 0 0 9 9 9 4 Leucine Rich repeat LRR_8 PF13855.6 CCM02331.1 - 0.0053 16.5 10.9 0.054 13.3 0.1 5.3 4 3 1 5 5 5 1 Leucine rich repeat LRR_1 PF00560.33 CCM02331.1 - 0.91 10.3 12.5 1.8e+02 3.3 0.0 6.9 8 0 0 8 8 8 0 Leucine Rich Repeat Amidohydro_3 PF07969.11 CCM02332.1 - 6e-12 45.8 1.1 4.1e-07 29.8 0.0 2.6 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 CCM02332.1 - 4.5e-11 42.7 0.0 6.5e-08 32.3 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family zf-RING_2 PF13639.6 CCM02334.1 - 6.5e-08 32.8 13.0 1.1e-07 32.0 13.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CCM02334.1 - 3.2e-07 30.3 10.8 6.1e-07 29.4 10.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCM02334.1 - 5e-07 29.6 11.2 8.1e-07 28.9 11.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCM02334.1 - 2.9e-06 27.0 13.7 5e-06 26.3 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM02334.1 - 7e-06 25.8 14.5 1.2e-05 25.1 14.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCM02334.1 - 2e-05 24.6 15.0 3.7e-05 23.8 15.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CCM02334.1 - 2e-05 24.3 13.2 3.3e-05 23.7 13.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FapA PF03961.13 CCM02334.1 - 0.0011 17.6 1.4 0.0016 17.2 1.4 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A zf-RING_11 PF17123.5 CCM02334.1 - 0.0051 16.5 9.0 0.011 15.5 9.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger ATG16 PF08614.11 CCM02334.1 - 0.013 15.7 8.0 0.04 14.1 8.0 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Leu_zip PF15294.6 CCM02334.1 - 0.029 13.9 4.2 0.044 13.3 4.2 1.3 1 0 0 1 1 1 0 Leucine zipper Tropomyosin_1 PF12718.7 CCM02334.1 - 0.035 14.3 6.3 0.076 13.2 6.3 1.5 1 0 0 1 1 1 0 Tropomyosin like zf-RING_4 PF14570.6 CCM02334.1 - 0.082 12.7 10.2 0.16 11.8 10.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 CCM02334.1 - 0.14 12.1 15.2 2.6 8.0 15.7 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF2381 PF09544.10 CCM02334.1 - 0.29 10.6 7.2 1.4 8.4 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) Pox_A_type_inc PF04508.12 CCM02334.1 - 0.31 11.0 8.4 0.43 10.5 0.1 3.3 3 0 0 3 3 2 0 Viral A-type inclusion protein repeat zf-Nse PF11789.8 CCM02334.1 - 0.36 10.7 8.7 1 9.2 8.7 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TMF_DNA_bd PF12329.8 CCM02334.1 - 0.45 10.5 8.6 1.2 9.2 1.7 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 CCM02334.1 - 0.54 10.1 6.3 2.1 8.1 0.5 2.4 2 0 0 2 2 2 0 Septum formation initiator zinc_ribbon_9 PF14369.6 CCM02334.1 - 0.68 10.2 6.0 0.8 10.0 1.8 2.5 2 0 0 2 2 2 0 zinc-ribbon FUSC PF04632.12 CCM02334.1 - 1.5 7.2 4.2 2.4 6.6 4.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-C3HC4_5 PF17121.5 CCM02334.1 - 1.6 8.7 7.7 4.1 7.4 7.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1090 PF06476.12 CCM02334.1 - 1.6 8.9 9.1 3.6 7.7 9.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) DUF4407 PF14362.6 CCM02334.1 - 1.7 7.9 5.7 2.7 7.3 5.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 CCM02334.1 - 4.3 8.0 6.9 19 6.0 0.8 3.1 3 0 0 3 3 3 0 SlyX Prok-RING_1 PF14446.6 CCM02334.1 - 5.3 7.1 13.9 1.1 9.2 5.7 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DZR PF12773.7 CCM02334.1 - 8.3 6.5 14.3 9.2 6.4 12.1 2.1 2 1 0 2 2 1 0 Double zinc ribbon Uso1_p115_C PF04871.13 CCM02334.1 - 8.6 6.7 12.8 0.52 10.7 7.3 1.8 2 0 0 2 2 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DctQ PF04290.12 CCM02335.1 - 0.017 15.1 1.5 0.017 15.1 1.5 2.2 3 1 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component TMEM164 PF14808.6 CCM02335.1 - 0.092 12.1 2.1 0.12 11.7 0.1 1.9 2 0 0 2 2 2 0 TMEM164 family MFS_1 PF07690.16 CCM02337.1 - 5.2e-35 121.0 48.6 1.7e-34 119.3 41.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM02337.1 - 4.8e-09 35.6 13.6 9.6e-09 34.6 11.7 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 CCM02337.1 - 1.9e-05 24.2 4.1 1.9e-05 24.2 4.1 1.8 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB Septin PF00735.18 CCM02339.1 - 1.3e-111 372.5 0.2 1.8e-111 372.0 0.2 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCM02339.1 - 6.1e-07 29.5 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM02339.1 - 1.5e-06 28.3 0.6 1.5e-05 25.0 0.2 2.4 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CCM02339.1 - 7.3e-06 25.6 1.1 0.00048 19.7 0.0 2.7 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCM02339.1 - 0.00049 20.5 0.1 0.0016 18.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 CCM02339.1 - 0.00093 19.4 0.0 0.0019 18.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 CCM02339.1 - 0.003 17.8 1.2 0.0086 16.4 0.1 2.3 2 1 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 CCM02339.1 - 0.004 16.9 0.2 0.17 11.7 0.2 2.4 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 CCM02339.1 - 0.0059 17.1 0.1 0.017 15.6 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 CCM02339.1 - 0.0073 15.7 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_7 PF12775.7 CCM02339.1 - 0.013 15.0 0.1 0.023 14.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 CCM02339.1 - 0.017 14.3 0.0 0.026 13.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 CCM02339.1 - 0.035 14.0 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Ras PF00071.22 CCM02339.1 - 0.037 13.6 0.1 0.11 12.1 0.1 1.8 1 1 0 1 1 1 0 Ras family AAA_25 PF13481.6 CCM02339.1 - 0.049 13.2 0.8 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CCM02339.1 - 0.049 13.3 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 CCM02339.1 - 0.059 13.4 0.1 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCM02339.1 - 0.061 13.0 0.3 0.14 11.9 0.3 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CCM02339.1 - 0.069 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 CCM02339.1 - 0.14 12.0 0.1 18 5.0 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FOXP-CC PF16159.5 CCM02339.1 - 0.14 12.8 1.0 0.42 11.3 1.0 1.8 1 0 0 1 1 1 0 FOXP coiled-coil domain Dynamin_N PF00350.23 CCM02339.1 - 0.22 11.6 6.4 3.8 7.5 0.1 2.9 2 1 1 3 3 3 0 Dynamin family XhlA PF10779.9 CCM02339.1 - 5.7 7.2 6.4 21 5.4 0.4 2.4 2 0 0 2 2 2 0 Haemolysin XhlA VWA_3_C PF18571.1 CCM02340.1 - 0.043 13.7 0.2 15 5.5 0.0 2.6 2 0 0 2 2 2 0 von Willebrand factor type A C-terminal domain Aldo_ket_red PF00248.21 CCM02341.1 - 3.1e-39 134.9 0.0 3.6e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 CCM02342.1 - 4.4e-51 173.8 0.0 5.3e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Asn_synthase PF00733.21 CCM02343.1 - 4e-98 329.4 0.0 2.3e-58 198.6 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 CCM02343.1 - 1.8e-35 121.6 0.0 2.9e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CCM02343.1 - 4.7e-28 98.0 0.0 1.1e-27 96.8 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 CCM02343.1 - 0.019 14.1 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 NAD synthase QueC PF06508.13 CCM02343.1 - 0.031 13.8 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC DUF3700 PF12481.8 CCM02343.1 - 0.037 13.5 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Aluminium induced protein RhoGEF PF00621.20 CCM02344.1 - 0.14 12.4 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 RhoGEF domain Methyltransf_16 PF10294.9 CCM02345.1 - 8.9e-16 58.1 0.0 1.1e-12 48.0 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CCM02345.1 - 0.00025 20.9 0.0 0.00033 20.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM02345.1 - 0.068 13.8 0.0 0.49 11.1 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain EF_assoc_1 PF08355.12 CCM02346.1 - 0.0085 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.12 CCM02346.1 - 0.0094 15.9 0.1 0.014 15.3 0.1 1.2 1 0 0 1 1 1 1 EF hand associated DEAD PF00270.29 CCM02347.1 - 4.9e-47 160.0 0.0 2.4e-46 157.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM02347.1 - 3.2e-28 98.3 0.0 1.7e-27 95.9 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM02347.1 - 0.00029 20.9 0.0 0.00078 19.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pkinase PF00069.25 CCM02348.1 - 4.5e-45 154.1 0.0 1.2e-44 152.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02348.1 - 8e-27 94.1 0.0 1.5e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM02348.1 - 0.0076 16.2 0.2 0.031 14.2 0.2 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM02348.1 - 0.11 11.2 0.3 0.37 9.5 0.3 1.9 1 1 0 1 1 1 0 Fungal protein kinase PRKCSH PF07915.13 CCM02349.1 - 1.5e-11 45.1 0.2 2.6e-11 44.4 0.2 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 CCM02349.1 - 0.0022 17.7 0.0 0.0047 16.6 0.0 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein AT_hook PF02178.19 CCM02350.1 - 0.00022 20.7 59.4 0.057 13.3 7.4 4.5 4 0 0 4 4 4 4 AT hook motif FAD_binding_3 PF01494.19 CCM02351.1 - 5.4e-21 75.2 0.0 8.6e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM02351.1 - 2.7e-06 26.8 0.0 0.00023 20.5 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM02351.1 - 1.8e-05 25.2 0.1 0.00051 20.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM02351.1 - 0.00033 20.4 0.0 0.0025 17.5 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCM02351.1 - 0.00034 20.8 0.0 0.0008 19.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CCM02351.1 - 0.0012 18.0 0.0 0.0016 17.6 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 CCM02351.1 - 0.0067 15.2 0.0 0.013 14.2 0.0 1.4 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CCM02351.1 - 0.015 14.6 0.1 0.023 14.0 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 CCM02351.1 - 0.018 14.4 0.0 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 CCM02351.1 - 0.021 14.3 0.0 0.047 13.2 0.0 1.6 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 CCM02351.1 - 0.087 12.1 0.1 0.95 8.7 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CCM02351.1 - 0.089 11.8 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase FAD_binding_2 PF00890.24 CCM02351.1 - 0.11 11.5 0.1 0.17 10.9 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 CCM02351.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AAA PF00004.29 CCM02352.1 - 5.6e-37 127.1 0.0 1.6e-36 125.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCM02352.1 - 2.9e-08 33.4 0.1 1.3e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 CCM02352.1 - 4.9e-05 23.8 4.4 0.013 15.9 0.0 4.7 5 2 0 5 5 5 1 AAA ATPase domain AAA_22 PF13401.6 CCM02352.1 - 0.00064 20.0 0.6 0.092 13.0 0.0 3.9 4 1 1 5 5 4 1 AAA domain AAA_5 PF07728.14 CCM02352.1 - 0.0015 18.6 0.2 0.01 15.9 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 CCM02352.1 - 0.012 14.8 0.0 0.031 13.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 CCM02352.1 - 0.014 16.0 0.2 0.2 12.2 0.0 2.7 3 0 0 3 3 2 0 AAA domain RuvB_N PF05496.12 CCM02352.1 - 0.015 15.0 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 CCM02352.1 - 0.016 15.0 0.0 0.68 9.6 0.0 3.2 2 2 1 3 3 3 0 AAA domain TIP49 PF06068.13 CCM02352.1 - 0.036 13.3 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_6 PF12774.7 CCM02352.1 - 0.044 12.8 0.2 0.15 11.0 0.0 1.8 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region IstB_IS21 PF01695.17 CCM02352.1 - 0.05 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 CCM02352.1 - 0.052 13.7 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCM02352.1 - 0.14 12.5 0.1 0.38 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CCM02352.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 CCM02352.1 - 0.17 11.3 0.0 2.2 7.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein SMC_Nse1 PF07574.13 CCM02353.1 - 3.1e-24 86.0 0.5 2.6e-22 79.7 0.5 2.4 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 CCM02353.1 - 7.3e-09 35.8 11.6 1.3e-08 35.0 11.6 1.4 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H PF13771.6 CCM02353.1 - 8e-05 22.8 2.8 0.00019 21.7 2.8 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-RING_2 PF13639.6 CCM02353.1 - 0.00018 21.7 8.2 0.00037 20.8 8.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-HC5HC2H_2 PF13832.6 CCM02353.1 - 0.0013 18.8 2.4 0.0028 17.8 2.4 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-rbx1 PF12678.7 CCM02353.1 - 0.017 15.4 5.1 0.017 15.4 5.1 1.8 2 0 0 2 2 1 0 RING-H2 zinc finger domain Baculo_IE-1 PF05290.11 CCM02353.1 - 0.017 15.1 0.7 0.03 14.3 0.7 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_2 PF13923.6 CCM02353.1 - 0.11 12.3 9.2 0.24 11.3 9.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 CCM02353.1 - 0.45 10.7 6.0 0.79 9.9 6.0 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 C1_1 PF00130.22 CCM02353.1 - 0.84 9.6 6.4 1.7 8.6 6.4 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4_3 PF13920.6 CCM02353.1 - 1.1 9.2 7.6 2 8.4 7.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 CCM02353.1 - 1.2 9.1 8.9 3.2 7.7 9.0 1.7 1 1 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 CCM02353.1 - 1.4 8.7 8.1 3.2 7.6 8.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.12 CCM02353.1 - 1.6 9.1 7.4 2 8.8 2.1 2.9 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding DUF3246 PF11596.8 CCM02353.1 - 6.1 6.2 11.6 0.3 10.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) zf-RING_5 PF14634.6 CCM02353.1 - 6.5 6.8 10.7 12 6.0 10.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain CDP-OH_P_transf PF01066.21 CCM02354.1 - 1.8e-12 47.9 1.6 2.5e-12 47.4 0.2 1.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DNA_primase_lrg PF04104.14 CCM02355.1 - 1.8e-88 296.4 0.0 2.8e-88 295.8 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit USP7_ICP0_bdg PF12436.8 CCM02357.1 - 2.9e-86 288.7 0.7 1.2e-84 283.4 0.1 3.3 2 2 2 4 4 4 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 CCM02357.1 - 5.3e-68 228.8 8.9 1.7e-66 223.9 1.2 3.6 2 1 1 4 4 4 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 CCM02357.1 - 7e-50 169.9 0.1 1.2e-49 169.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM02357.1 - 1.1e-20 74.5 0.0 2.3e-20 73.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 CCM02357.1 - 1.8e-08 34.5 0.0 2.5e-07 30.8 0.0 2.7 2 1 0 2 2 2 1 MATH domain ubiquitin PF00240.23 CCM02357.1 - 0.0011 18.7 0.6 0.43 10.4 0.0 4.3 5 0 0 5 5 5 1 Ubiquitin family UN_NPL4 PF11543.8 CCM02357.1 - 0.0044 17.5 1.3 7.3 7.2 0.0 3.7 4 0 0 4 4 4 2 Nuclear pore localisation protein NPL4 HSDR_N_2 PF13588.6 CCM02357.1 - 0.04 13.9 0.1 0.22 11.5 0.0 2.3 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Sec66 PF09802.9 CCM02358.1 - 1.6e-58 197.2 0.1 2e-58 196.9 0.1 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 SKG6 PF08693.10 CCM02358.1 - 0.18 11.2 1.2 0.32 10.5 1.2 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Citrate_synt PF00285.21 CCM02359.1 - 8.2e-99 331.1 0.0 1e-98 330.8 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain TFIIA PF03153.13 CCM02360.1 - 0.27 11.2 10.9 0.37 10.7 10.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 CCM02360.1 - 2.6 7.4 12.3 9.7 5.5 12.1 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region PAT1 PF09770.9 CCM02360.1 - 6.3 4.9 9.3 7.8 4.6 9.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 B56 PF01603.20 CCM02361.1 - 1.6e-190 633.5 8.3 1.9e-190 633.3 8.3 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) SPX PF03105.19 CCM02361.1 - 0.1 12.5 6.7 0.14 12.1 6.7 1.2 1 0 0 1 1 1 0 SPX domain Glyco_transf_15 PF01793.16 CCM02362.1 - 8.4e-17 61.4 0.1 8.9e-17 61.3 0.1 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DAPDH_C PF16654.5 CCM02362.1 - 0.095 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain Glyco_transf_15 PF01793.16 CCM02363.1 - 1.6e-58 198.5 0.9 1.8e-58 198.3 0.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PI3_PI4_kinase PF00454.27 CCM02364.1 - 8.3e-35 120.8 0.0 1.3e-33 116.9 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase OST3_OST6 PF04756.13 CCM02365.1 - 8.7e-88 294.5 0.1 9.9e-88 294.3 0.1 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 CCM02365.1 - 0.00035 20.5 0.0 0.00064 19.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DUF4149 PF13664.6 CCM02365.1 - 0.22 11.9 4.8 1.1 9.6 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) Bax1-I PF01027.20 CCM02365.1 - 0.84 9.4 8.6 3 7.6 2.9 2.3 1 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 Sec16_C PF12931.7 CCM02366.1 - 1e-102 343.9 0.0 1.5e-102 343.3 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 CCM02366.1 - 3e-31 108.4 0.5 1.2e-29 103.3 0.0 3.0 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region PUF PF00806.19 CCM02367.1 - 2e-60 197.2 1.6 2.2e-08 33.3 0.0 8.7 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat CPL PF08144.11 CCM02367.1 - 0.00072 19.9 3.3 0.15 12.4 0.1 4.0 2 2 2 4 4 4 2 CPL (NUC119) domain Kinesin PF00225.23 CCM02368.1 - 2e-113 378.7 0.2 4.9e-113 377.4 0.2 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCM02368.1 - 1.6e-28 99.5 0.0 5.3e-28 97.8 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding DUF465 PF04325.13 CCM02368.1 - 1.1e-05 25.3 5.0 1.1e-05 25.3 5.0 3.6 2 1 0 2 2 2 1 Protein of unknown function (DUF465) DASH_Dam1 PF08653.10 CCM02368.1 - 5.1 7.0 7.7 32 4.4 0.2 4.8 4 0 0 4 4 4 0 DASH complex subunit Dam1 Elf1 PF05129.13 CCM02369.1 - 1.6e-28 98.6 0.3 1.9e-28 98.3 0.3 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like PHD_4 PF16866.5 CCM02369.1 - 0.046 13.8 0.2 0.065 13.3 0.2 1.3 1 0 0 1 1 1 0 PHD-finger zf-CHY PF05495.12 CCM02369.1 - 0.049 14.1 0.9 0.073 13.6 0.9 1.3 1 0 0 1 1 1 0 CHY zinc finger Kinesin PF00225.23 CCM02370.1 - 4.3e-109 364.5 0.0 8e-109 363.6 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Vps55 PF04133.14 CCM02370.1 - 6.5e-40 135.7 2.5 1e-39 135.1 2.5 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Microtub_bd PF16796.5 CCM02370.1 - 3.3e-25 88.8 0.0 1.1e-24 87.1 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding Microtub_bind PF13931.6 CCM02370.1 - 1.1e-05 25.8 0.2 1.1e-05 25.8 0.2 3.9 3 1 1 4 4 4 1 Kinesin-associated microtubule-binding Fib_alpha PF08702.10 CCM02370.1 - 0.037 14.2 0.4 0.037 14.2 0.4 5.2 2 2 4 6 6 6 0 Fibrinogen alpha/beta chain family ERp29 PF07749.12 CCM02370.1 - 1.2 10.0 5.1 4 8.4 0.1 3.6 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain Lant_dehydr_C PF14028.6 CCM02370.1 - 2 7.9 8.4 0.8 9.2 2.6 2.7 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term LprI PF07007.12 CCM02370.1 - 5.3 7.8 9.7 0.25 12.0 1.7 3.0 2 1 1 3 3 3 0 Lysozyme inhibitor LprI PRIMA1 PF16101.5 CCM02370.1 - 9.1 6.3 7.2 0.64 10.1 1.9 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 SHE3 PF17078.5 CCM02370.1 - 9.2 5.9 24.7 0.044 13.5 3.0 3.5 2 1 0 3 3 3 0 SWI5-dependent HO expression protein 3 TRAPPC9-Trs120 PF08626.11 CCM02371.1 - 1.1e-199 665.6 0.0 5.6e-198 660.0 0.0 2.0 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit C1_1 PF00130.22 CCM02372.1 - 1.5e-06 28.0 15.4 1e-05 25.3 4.0 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) UNC-79 PF14776.6 CCM02372.1 - 2.2e-06 26.8 0.1 9.4e-06 24.7 0.0 2.0 2 0 0 2 2 2 1 Cation-channel complex subunit UNC-79 PHD PF00628.29 CCM02372.1 - 0.022 14.6 14.3 0.43 10.5 3.4 2.5 2 0 0 2 2 2 0 PHD-finger Zn_ribbon_17 PF17120.5 CCM02372.1 - 0.046 13.4 13.5 0.26 11.0 3.5 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DZR PF12773.7 CCM02372.1 - 0.1 12.6 5.1 3.2 7.8 0.9 2.5 2 0 0 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 CCM02372.1 - 0.48 10.8 14.4 3.7 7.9 2.3 2.6 2 0 0 2 2 2 0 C1 domain PHD_2 PF13831.6 CCM02372.1 - 2.4 7.8 8.3 5.1 6.7 0.8 2.7 2 0 0 2 2 2 0 PHD-finger DUF4211 PF13926.6 CCM02373.1 - 5.3e-35 120.6 0.4 3.2e-34 118.1 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) TFIID-18kDa PF02269.16 CCM02374.1 - 1.2e-21 76.5 0.1 1.6e-21 76.1 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit RRM_1 PF00076.22 CCM02375.1 - 2.8e-15 55.9 0.1 6.1e-15 54.8 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM02375.1 - 8.8e-08 32.2 0.0 1.2e-07 31.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM PF05172.13 CCM02375.1 - 0.018 15.0 0.0 0.044 13.7 0.0 1.7 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Pkinase PF00069.25 CCM02376.1 - 6.4e-10 38.8 0.0 1.8e-09 37.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCM02376.1 - 0.0025 17.8 0.1 0.005 16.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCM02376.1 - 0.0029 17.0 0.6 0.0044 16.4 0.6 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CCM02376.1 - 0.22 11.1 0.9 0.34 10.5 0.9 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF2040 PF09745.9 CCM02377.1 - 7.1e-39 132.6 20.1 7.1e-39 132.6 20.1 3.3 3 1 1 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) NAD_binding_4 PF07993.12 CCM02378.1 - 3.7e-30 105.0 0.0 6e-30 104.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein RNase_PH PF01138.21 CCM02378.1 - 1.2e-27 97.0 0.5 3.5e-27 95.5 0.2 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 AMP-binding PF00501.28 CCM02378.1 - 1.7e-18 66.5 0.1 1.5e-10 40.3 0.1 3.0 3 0 0 3 3 3 2 AMP-binding enzyme Epimerase PF01370.21 CCM02378.1 - 2.4e-08 33.7 0.0 4.2e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM02378.1 - 0.00054 20.3 0.0 0.0016 18.8 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site AA_permease_2 PF13520.6 CCM02379.1 - 1e-64 219.0 39.3 1.4e-64 218.6 39.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCM02379.1 - 3.1e-26 92.0 35.2 4e-26 91.6 35.2 1.1 1 0 0 1 1 1 1 Amino acid permease HMA PF00403.26 CCM02379.1 - 4.8e-12 46.1 1.5 8.1e-12 45.4 1.5 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain Ribosomal_S9 PF00380.19 CCM02379.1 - 0.024 15.2 0.1 0.4 11.2 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein S9/S16 DUF2140 PF09911.9 CCM02379.1 - 0.11 12.1 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) zinc_ribbon_12 PF11331.8 CCM02379.1 - 3.6 7.5 5.4 21 5.0 0.0 2.4 2 0 0 2 2 2 0 Probable zinc-ribbon domain Ferric_reduct PF01794.19 CCM02380.1 - 4.9e-19 68.7 13.5 4.9e-19 68.7 13.5 2.3 2 2 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCM02380.1 - 1e-09 38.5 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CCM02380.1 - 1e-06 28.9 0.1 0.0045 17.1 0.0 2.5 2 0 0 2 2 2 2 Ferric reductase NAD binding domain MAGE_N PF12440.8 CCM02380.1 - 0.072 13.8 7.0 0.1 13.3 5.7 2.0 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal TRM PF02005.16 CCM02381.1 - 4.5e-120 401.3 0.0 6.5e-120 400.8 0.0 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Spermine_synth PF01564.17 CCM02381.1 - 0.039 13.4 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Met_10 PF02475.16 CCM02381.1 - 0.14 11.8 0.2 0.66 9.7 0.2 2.1 1 1 0 1 1 1 0 Met-10+ like-protein zf-H2C2_2 PF13465.6 CCM02381.1 - 0.91 10.1 5.2 0.28 11.7 0.8 2.5 2 0 0 2 2 2 0 Zinc-finger double domain ADK_lid PF05191.14 CCM02381.1 - 1.1 9.3 4.3 8.5 6.5 4.3 2.3 1 1 0 1 1 1 0 Adenylate kinase, active site lid Pkinase PF00069.25 CCM02382.1 - 2.5e-71 240.1 0.0 3.4e-71 239.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02382.1 - 2.1e-49 168.1 0.0 3.4e-49 167.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 CCM02382.1 - 3.6e-11 43.3 0.0 7.5e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 Kinase-like PF14531.6 CCM02382.1 - 6.5e-07 29.0 0.0 0.00028 20.3 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SDA1 PF05285.12 CCM02382.1 - 0.018 14.5 13.5 0.027 13.9 13.5 1.2 1 0 0 1 1 1 0 SDA1 APH PF01636.23 CCM02382.1 - 0.055 13.4 0.2 4.5 7.1 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM02382.1 - 0.064 12.0 0.0 0.16 10.7 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase TFIIA PF03153.13 CCM02382.1 - 0.081 12.9 4.8 0.15 12.1 4.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Y1_Tnp PF01797.16 CCM02382.1 - 0.19 11.8 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 Transposase IS200 like PPP4R2 PF09184.11 CCM02382.1 - 1.7 8.2 14.6 2.7 7.5 14.6 1.3 1 0 0 1 1 1 0 PPP4R2 DUF4746 PF15928.5 CCM02382.1 - 1.7 8.0 8.4 3.1 7.1 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Alpha-amylase PF00128.24 CCM02383.1 - 2.9e-19 69.8 5.2 2.6e-18 66.7 5.2 2.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 CCM02383.1 - 2.9e-14 53.4 0.0 5.7e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 CCM02383.1 - 1.2e-07 31.5 0.0 2.2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Methyltransf_11 PF08241.12 CCM02384.1 - 2.3e-13 50.6 0.0 4.4e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM02384.1 - 2.1e-10 41.2 0.0 6.5e-10 39.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM02384.1 - 3.3e-06 27.8 0.0 7e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM02384.1 - 5.5e-06 26.3 0.0 8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM02384.1 - 0.0076 15.6 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_28 PF02636.17 CCM02384.1 - 0.016 14.8 0.0 0.041 13.5 0.0 1.8 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_16 PF10294.9 CCM02384.1 - 0.057 13.2 0.0 0.086 12.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_31 PF13847.6 CCM02384.1 - 0.15 11.9 0.0 5 6.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain DAGK_cat PF00781.24 CCM02385.1 - 5.4e-26 90.7 0.0 8.8e-26 90.0 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Abhydrolase_3 PF07859.13 CCM02387.1 - 1.1e-48 165.9 0.0 1.4e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCM02387.1 - 0.00016 20.7 0.0 0.00043 19.3 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family DLH PF01738.18 CCM02387.1 - 0.03 13.9 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family F-box-like PF12937.7 CCM02388.1 - 7.4e-08 32.2 0.0 3.4e-07 30.0 0.0 2.3 1 0 0 1 1 1 1 F-box-like HSP90 PF00183.18 CCM02389.1 - 9.2e-228 757.3 28.0 1.2e-227 757.0 28.0 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CCM02389.1 - 2.2e-14 53.9 0.0 4.3e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCM02389.1 - 8.3e-10 38.6 0.1 2.2e-09 37.3 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 CCM02389.1 - 0.049 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN Peptidase_C37 PF05416.12 CCM02389.1 - 5.1 5.5 8.5 2.6 6.4 0.2 2.2 2 0 0 2 2 2 0 Southampton virus-type processing peptidase DUF3418 PF11898.8 CCM02390.1 - 0.00023 20.0 16.7 0.00023 20.0 16.7 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3418) DHR10 PF18595.1 CCM02390.1 - 0.00034 20.7 10.6 0.00034 20.7 10.6 3.9 4 0 0 4 4 4 1 Designed helical repeat protein 10 domain V-SNARE PF05008.15 CCM02390.1 - 0.081 13.3 0.2 0.081 13.3 0.2 3.9 4 1 1 5 5 5 0 Vesicle transport v-SNARE protein N-terminus bZIP_1 PF00170.21 CCM02390.1 - 0.2 11.8 0.2 0.2 11.8 0.2 3.5 4 0 0 4 4 4 0 bZIP transcription factor Sulfotransfer_4 PF17784.1 CCM02390.1 - 1.9 8.3 6.4 0.47 10.3 3.0 1.8 2 0 0 2 2 2 0 Sulfotransferase domain FlaC_arch PF05377.11 CCM02390.1 - 3.9 8.0 9.5 4.1 7.9 0.3 4.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Cerato-platanin PF07249.12 CCM02392.1 - 9.7e-28 96.7 1.4 1.2e-27 96.4 1.4 1.1 1 0 0 1 1 1 1 Cerato-platanin DUF1264 PF06884.11 CCM02393.1 - 3.7e-71 238.2 0.1 5.2e-71 237.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) NAC PF01849.18 CCM02395.1 - 8.4e-21 73.7 0.0 2e-20 72.5 0.0 1.6 2 0 0 2 2 2 1 NAC domain UBA_4 PF14555.6 CCM02395.1 - 0.019 14.8 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain Methyltransf_25 PF13649.6 CCM02396.1 - 3.7e-07 30.7 0.0 1.3e-06 29.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM02396.1 - 7.1e-07 29.8 0.0 1.4e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM02396.1 - 0.016 15.0 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Glyco_tran_28_C PF04101.16 CCM02397.1 - 3.8e-32 111.6 0.0 4.3e-32 111.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain P5CR_dimer PF14748.6 CCM02398.1 - 1.3e-38 131.3 4.4 1.9e-38 130.9 1.4 2.5 2 1 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CCM02398.1 - 0.00028 21.4 0.0 0.47 11.1 0.0 2.7 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent AAA PF00004.29 CCM02399.1 - 2.2e-44 151.1 0.1 6.2e-44 149.6 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCM02399.1 - 1.9e-10 40.5 0.1 1.3e-09 37.9 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CCM02399.1 - 1.6e-08 34.6 0.1 5.4e-08 32.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCM02399.1 - 5.2e-08 33.5 0.3 2.8e-05 24.6 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 CCM02399.1 - 8e-08 32.6 0.2 3.3e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 CCM02399.1 - 3e-06 26.6 0.1 6.8e-06 25.4 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CCM02399.1 - 7.1e-05 23.4 0.0 0.0017 18.9 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 CCM02399.1 - 0.00035 20.8 0.0 0.0012 19.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_lid_3 PF17862.1 CCM02399.1 - 0.00036 20.3 0.0 0.00086 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 CCM02399.1 - 0.00045 20.3 0.0 0.0018 18.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CCM02399.1 - 0.00048 19.9 0.0 0.0016 18.2 0.0 1.9 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCM02399.1 - 0.00064 20.0 4.5 0.013 15.7 0.1 3.0 3 1 1 4 4 2 1 AAA domain TsaE PF02367.17 CCM02399.1 - 0.00065 19.7 0.0 0.0081 16.2 0.0 2.4 1 1 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 CCM02399.1 - 0.001 19.0 0.1 0.01 15.8 0.0 2.6 3 0 0 3 3 3 1 NTPase TIP49 PF06068.13 CCM02399.1 - 0.0016 17.7 0.0 0.0034 16.6 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 CCM02399.1 - 0.0027 18.1 0.0 0.0064 16.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase CENP-F_leu_zip PF10473.9 CCM02399.1 - 0.003 17.6 1.6 0.006 16.6 1.6 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_30 PF13604.6 CCM02399.1 - 0.0031 17.3 0.3 0.0092 15.7 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCM02399.1 - 0.0034 16.9 0.1 0.024 14.1 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 CCM02399.1 - 0.0045 16.7 0.2 0.024 14.4 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.6 CCM02399.1 - 0.005 17.0 0.0 0.018 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CCM02399.1 - 0.0088 15.5 0.1 0.021 14.2 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCM02399.1 - 0.0096 15.8 0.0 0.028 14.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CCM02399.1 - 0.011 15.7 0.1 0.084 12.8 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 CCM02399.1 - 0.012 15.2 0.3 0.043 13.4 0.3 1.9 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 CCM02399.1 - 0.013 14.9 0.5 0.63 9.4 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein AAA_24 PF13479.6 CCM02399.1 - 0.028 14.1 0.1 0.058 13.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CCM02399.1 - 0.029 14.2 0.2 0.074 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CCM02399.1 - 0.045 14.1 0.1 0.13 12.5 0.1 1.7 1 0 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.16 CCM02399.1 - 0.063 12.1 0.0 0.12 11.2 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase Bac_DnaA PF00308.18 CCM02399.1 - 0.071 12.9 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial dnaA protein Sigma54_activat PF00158.26 CCM02399.1 - 0.079 12.7 0.2 1.2 8.8 0.0 2.8 3 1 0 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.27 CCM02399.1 - 0.12 12.9 0.1 0.88 10.1 0.0 2.5 3 0 0 3 3 2 0 ABC transporter ATPase_2 PF01637.18 CCM02399.1 - 0.13 12.1 1.7 0.69 9.8 0.0 2.7 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 CCM02399.1 - 0.15 11.1 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 CCM02399.1 - 0.16 11.3 1.1 0.52 9.6 0.0 2.2 3 0 0 3 3 3 0 KaiC DnaB_C PF03796.15 CCM02399.1 - 0.52 9.6 2.7 12 5.1 0.6 2.7 2 1 1 3 3 3 0 DnaB-like helicase C terminal domain RRM_1 PF00076.22 CCM02400.1 - 1.1e-12 47.6 0.0 2.7e-12 46.3 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 CCM02401.1 - 0.017 15.0 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bac_rhodopsin PF01036.18 CCM02402.1 - 1.6e-38 132.5 19.4 2.2e-38 132.0 19.4 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Arteri_Gl PF00951.18 CCM02402.1 - 1.1 9.1 9.9 0.062 13.1 4.5 1.7 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein SNRNP27 PF08648.12 CCM02403.1 - 3.6e-21 75.0 1.7 6.9e-21 74.1 1.7 1.5 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins PAP1 PF08601.10 CCM02403.1 - 0.022 14.5 0.1 0.026 14.3 0.1 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 SUI1 PF01253.22 CCM02404.1 - 1.5e-24 86.3 0.6 1.9e-12 47.5 0.2 2.1 2 0 0 2 2 2 2 Translation initiation factor SUI1 rRNA_processing PF08524.11 CCM02405.1 - 0.0028 17.7 0.1 0.0028 17.7 0.1 2.8 2 1 0 2 2 2 1 rRNA processing PPP4R2 PF09184.11 CCM02406.1 - 1.7e-18 67.2 0.8 2e-18 67.0 0.0 1.4 2 0 0 2 2 2 1 PPP4R2 DUF5448 PF17526.2 CCM02406.1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5448) RB_A PF01858.17 CCM02406.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain PAP2 PF01569.21 CCM02407.1 - 4.1e-33 114.0 2.1 6.8e-33 113.3 2.1 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 CCM02407.1 - 0.0094 15.6 8.2 0.065 12.9 8.2 2.0 1 1 0 1 1 1 1 PAP2 superfamily TspO_MBR PF03073.15 CCM02407.1 - 0.028 14.5 1.7 0.07 13.2 0.2 2.1 2 0 0 2 2 2 0 TspO/MBR family DUF5510 PF17629.2 CCM02407.1 - 0.27 11.2 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5510) FSA_C PF10479.9 CCM02408.1 - 8.2 4.4 16.7 18 3.3 16.7 1.6 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus RabGAP-TBC PF00566.18 CCM02409.1 - 2.1e-42 145.2 5.3 1.6e-39 135.8 2.0 2.6 2 0 0 2 2 2 2 Rab-GTPase-TBC domain PH_RBD PF12068.8 CCM02409.1 - 7.4e-11 41.8 0.2 6e-09 35.6 0.0 2.4 1 1 1 2 2 2 2 Rab-binding domain (RBD) REV PF00424.18 CCM02409.1 - 0.19 11.8 2.0 0.25 11.4 0.6 1.9 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) ox_reductase_C PF08635.10 CCM02410.1 - 1.1e-72 242.3 0.1 1.8e-72 241.6 0.1 1.3 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain Ribosomal_S21e PF01249.18 CCM02410.1 - 4.4e-38 129.3 0.1 1.2e-37 127.8 0.1 1.8 1 0 0 1 1 1 1 Ribosomal protein S21e GFO_IDH_MocA PF01408.22 CCM02410.1 - 2.5e-18 67.0 0.0 5.8e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCM02410.1 - 0.017 15.1 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain DUF4763 PF15960.5 CCM02410.1 - 0.045 13.1 0.1 0.074 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) SKA2 PF16740.5 CCM02410.1 - 0.084 12.7 0.3 0.21 11.4 0.3 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 SlyX PF04102.12 CCM02410.1 - 0.25 12.0 1.3 0.62 10.7 1.3 1.7 1 0 0 1 1 1 0 SlyX zf-C2HE PF16278.5 CCM02411.1 - 5.8e-16 58.7 0.1 1.6e-15 57.3 0.1 1.8 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 CCM02411.1 - 4.4e-14 52.9 0.0 7.6e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 CCM02411.1 - 4.9e-09 36.8 0.0 9.7e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 HIT domain PRIMA1 PF16101.5 CCM02412.1 - 2.3 8.3 6.1 4.4 7.4 6.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 CCM02412.1 - 4.4 6.7 4.2 7.5 5.9 4.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SAP PF02037.27 CCM02413.1 - 3.1e-10 39.6 0.6 8.8e-10 38.1 0.6 1.7 2 0 0 2 2 2 1 SAP domain DUF2315 PF10231.9 CCM02414.1 - 2.9e-32 111.3 2.8 3.5e-32 111.1 2.8 1.1 1 0 0 1 1 1 1 Apoptogenic protein 1 Nucleoporin_C PF03177.14 CCM02415.1 - 4e-77 260.3 0.9 5.6e-77 259.9 0.9 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 CCM02415.1 - 3.5e-09 35.9 0.0 5.3e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like PRCC PF10253.9 CCM02416.1 - 1.9e-34 120.3 3.1 1.9e-34 120.3 3.1 2.6 2 2 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Histone PF00125.24 CCM02417.1 - 1.6e-20 73.8 3.4 2.7e-20 73.0 3.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCM02417.1 - 0.00026 21.2 1.6 0.00027 21.2 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CCM02417.1 - 0.0021 18.5 0.0 0.0041 17.6 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A MaoC_dehydratas PF01575.19 CCM02417.1 - 0.0087 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain DUF4228 PF14009.6 CCM02417.1 - 0.032 14.6 0.6 4.3 7.7 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) DUF3408 PF11888.8 CCM02417.1 - 0.29 11.3 2.1 0.51 10.5 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Aminotran_5 PF00266.19 CCM02419.1 - 2.1e-37 128.9 0.0 4.1e-37 128.0 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V SKN1 PF03935.15 CCM02420.1 - 9.9e-07 27.5 0.0 1.3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Neurensin PF14927.6 CCM02420.1 - 0.0033 17.1 0.0 0.0049 16.6 0.0 1.2 1 0 0 1 1 1 1 Neurensin TM_helix PF05552.12 CCM02420.1 - 0.12 12.4 1.7 0.18 11.8 1.7 1.2 1 0 0 1 1 1 0 Conserved TM helix Kunitz_BPTI PF00014.23 CCM02420.1 - 0.13 12.5 0.1 0.22 11.8 0.1 1.3 1 0 0 1 1 1 0 Kunitz/Bovine pancreatic trypsin inhibitor domain SelK_SelG PF10961.8 CCM02424.1 - 0.0086 16.7 0.4 0.0088 16.6 0.4 1.1 1 0 0 1 1 1 1 Selenoprotein SelK_SelG EF-hand_1 PF00036.32 CCM02425.1 - 5.2e-43 141.4 12.2 4.3e-10 38.4 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCM02425.1 - 6.6e-37 125.8 2.8 4.4e-19 68.7 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CCM02425.1 - 1.2e-32 111.5 10.9 2.2e-13 49.8 0.6 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CCM02425.1 - 1e-31 106.1 6.8 1.3e-09 37.2 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CCM02425.1 - 1.1e-27 94.2 8.5 1.6e-06 27.3 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CCM02425.1 - 2.4e-16 59.8 0.3 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CCM02425.1 - 3.2e-10 39.9 0.7 7.6e-05 22.6 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CCM02425.1 - 1.5e-08 35.0 0.0 0.0015 18.8 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 CCM02425.1 - 1.2e-06 28.5 0.1 0.042 13.9 0.0 3.3 3 1 1 4 4 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 CCM02425.1 - 2.8e-05 24.9 0.0 0.019 15.8 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 CCM02425.1 - 7.6e-05 22.7 1.0 0.00035 20.6 0.1 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 CCM02425.1 - 0.00025 21.2 5.8 0.026 14.7 0.9 3.0 1 1 3 4 4 4 2 Dockerin type I domain DUF1103 PF06513.11 CCM02425.1 - 0.00039 20.1 1.2 0.00045 19.9 1.2 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Caleosin PF05042.13 CCM02425.1 - 0.00061 19.8 0.5 0.4 10.6 0.0 3.3 1 1 3 4 4 4 1 Caleosin related protein DUF3349 PF11829.8 CCM02425.1 - 0.0019 18.9 0.2 1.5 9.7 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF4497 PF14924.6 CCM02425.1 - 0.0029 18.1 0.0 1.1 9.8 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4497) Poly_export PF02563.16 CCM02425.1 - 0.0029 17.8 0.1 0.74 10.1 0.0 3.0 1 1 2 3 3 3 1 Polysaccharide biosynthesis/export protein TerB PF05099.13 CCM02425.1 - 0.0029 17.5 0.2 0.48 10.4 0.0 2.3 1 1 1 2 2 2 1 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 CCM02425.1 - 0.0096 16.2 0.5 5.9 7.2 0.1 2.6 3 0 0 3 3 2 1 RNA polymerase Rpb4 EF-hand_14 PF17959.1 CCM02425.1 - 0.012 16.0 0.1 5.4 7.4 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain MotA_activ PF09114.10 CCM02425.1 - 0.02 15.0 0.4 0.3 11.2 0.1 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain DUF5580 PF17743.1 CCM02425.1 - 0.02 13.5 0.0 0.02 13.5 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 CCM02425.1 - 0.023 14.5 0.5 1.5 8.7 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain Fe_hyd_lg_C PF02906.14 CCM02425.1 - 0.059 13.0 0.3 0.099 12.3 0.3 1.5 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain DUF1811 PF08838.10 CCM02425.1 - 0.061 13.6 0.0 16 5.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) dCache_2 PF08269.11 CCM02425.1 - 0.062 12.5 0.2 5.2 6.2 0.1 2.3 1 1 1 2 2 2 0 Cache domain Spore_III_AB PF09548.10 CCM02425.1 - 0.09 12.9 0.3 0.19 11.9 0.3 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) FGAR-AT_linker PF18072.1 CCM02425.1 - 0.15 12.6 0.2 7.1 7.3 0.0 2.6 2 1 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain RuvA_C PF07499.13 CCM02425.1 - 0.15 12.5 0.0 9.7 6.7 0.0 2.9 3 0 0 3 3 3 0 RuvA, C-terminal domain LRR_6 PF13516.6 CCM02426.1 - 2.8e-18 64.3 16.5 0.0021 18.0 0.1 8.9 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 CCM02426.1 - 1.4e-07 31.7 10.9 0.034 14.6 0.4 5.3 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) GAT PF03127.14 CCM02426.1 - 0.0002 21.6 0.1 0.00097 19.4 0.0 2.1 2 0 0 2 2 2 1 GAT domain LRR_1 PF00560.33 CCM02426.1 - 0.0004 20.6 7.0 27 5.8 0.0 6.7 6 0 0 6 6 6 1 Leucine Rich Repeat SUZ PF12752.7 CCM02426.1 - 1.3 9.8 5.0 0.82 10.5 0.4 3.0 2 1 0 2 2 2 0 SUZ domain LRR_8 PF13855.6 CCM02426.1 - 1.9 8.3 26.5 1.1 9.0 1.5 6.4 7 2 0 7 7 7 0 Leucine rich repeat Neisseria_TspB PF05616.13 CCM02427.1 - 5.2 5.4 8.0 5.9 5.3 8.0 1.0 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein AhpC-TSA PF00578.21 CCM02428.1 - 8.4e-28 96.8 0.0 1.2e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCM02428.1 - 5.4e-18 65.1 0.0 9.3e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin HMG14_17 PF01101.18 CCM02428.1 - 0.029 15.3 17.5 0.07 14.1 17.5 1.6 1 0 0 1 1 1 0 HMG14 and HMG17 AhpC-TSA_2 PF13911.6 CCM02428.1 - 0.062 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme Peptidase_M20 PF01546.28 CCM02429.1 - 3.9e-20 72.5 0.0 5.5e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM02429.1 - 1.5e-10 41.0 0.3 3.4e-10 39.8 0.3 1.6 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCM02429.1 - 0.041 13.6 0.0 0.071 12.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 RhoGAP PF00620.27 CCM02430.1 - 6.1e-36 123.5 0.0 1.1e-35 122.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 CCM02430.1 - 5.6e-28 96.9 40.6 2.6e-11 43.6 7.5 4.7 4 0 0 4 4 4 4 LIM domain Ribosomal_S19 PF00203.21 CCM02431.1 - 1.9e-31 107.8 0.3 3.1e-31 107.1 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_60s PF00428.19 CCM02432.1 - 5.2e-27 94.3 10.7 6.2e-27 94.0 10.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein EF-hand_14 PF17959.1 CCM02432.1 - 0.0081 16.5 0.5 0.01 16.1 0.0 1.4 2 0 0 2 2 2 1 EF-hand domain RibD_C PF01872.17 CCM02432.1 - 0.15 11.9 1.1 0.59 9.9 0.1 1.9 1 1 1 2 2 2 0 RibD C-terminal domain Fungal_trans PF04082.18 CCM02433.1 - 2.1e-14 53.2 0.3 3.3e-14 52.5 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain V-ATPase_G PF03179.15 CCM02434.1 - 2.2e-31 108.5 15.3 2.5e-31 108.3 15.3 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Glyco_hydro_15 PF00723.21 CCM02434.1 - 0.02 13.7 0.5 0.024 13.5 0.5 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 15 ATP-synt_B PF00430.18 CCM02434.1 - 1.3 9.1 20.7 0.32 11.1 14.8 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Symplekin_C PF12295.8 CCM02435.1 - 7.2e-64 215.3 0.2 2.1e-63 213.8 0.2 1.9 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 CCM02435.1 - 6.1e-49 166.7 1.8 7.4e-49 166.4 0.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) HEAT PF02985.22 CCM02435.1 - 0.14 12.5 0.0 23 5.6 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat RNA_pol_Rpc4 PF05132.14 CCM02436.1 - 9.3e-34 117.0 0.3 9.3e-34 117.0 0.3 2.1 2 0 0 2 2 2 1 RNA polymerase III RPC4 Fe-ADH PF00465.19 CCM02438.1 - 0.015 14.1 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Pribosyltran PF00156.27 CCM02438.1 - 0.092 12.3 0.1 0.55 9.7 0.1 1.9 1 1 0 1 1 1 0 Phosphoribosyl transferase domain Mito_carr PF00153.27 CCM02439.1 - 3.4e-68 225.6 3.7 1.1e-22 79.7 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein KduI PF04962.12 CCM02439.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 KduI/IolB family TFIID_30kDa PF03540.13 CCM02440.1 - 5.9e-26 90.2 0.1 9.9e-26 89.4 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit DUF4106 PF13388.6 CCM02440.1 - 0.02 14.2 1.1 0.021 14.1 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Bromo_TP PF07524.13 CCM02440.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Ribosomal_60s PF00428.19 CCM02440.1 - 0.67 10.6 0.0 0.67 10.6 0.0 2.5 2 1 0 2 2 2 0 60s Acidic ribosomal protein GFO_IDH_MocA PF01408.22 CCM02441.1 - 1.3e-14 55.0 0.1 2e-14 54.4 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold SAGA-Tad1 PF12767.7 CCM02442.1 - 1e-24 87.6 0.0 1.9e-24 86.7 0.0 1.4 1 1 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 CCM02442.1 - 0.031 14.0 0.5 0.044 13.5 0.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family zf-CCCH PF00642.24 CCM02443.1 - 3.6e-05 23.5 8.9 0.03 14.2 0.8 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCM02443.1 - 5.6e-05 22.8 10.9 0.031 14.1 2.2 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf-RING_2 PF13639.6 CCM02443.1 - 0.00032 21.0 2.7 0.00032 21.0 2.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf_CCCH_4 PF18345.1 CCM02443.1 - 0.0007 19.6 2.4 0.0007 19.6 2.4 3.3 3 0 0 3 3 3 2 Zinc finger domain zf-RING_5 PF14634.6 CCM02443.1 - 0.0009 19.2 1.1 0.0021 18.0 1.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CCM02443.1 - 0.0028 17.5 3.5 0.011 15.6 3.6 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM02443.1 - 0.01 15.7 2.2 0.043 13.7 2.2 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Inhibitor_I36 PF03995.13 CCM02443.1 - 0.02 14.8 0.4 0.02 14.8 0.4 2.3 2 0 0 2 2 2 0 Peptidase inhibitor family I36 zf-CCCH_2 PF14608.6 CCM02443.1 - 0.026 15.0 10.3 0.75 10.4 4.5 2.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger LexA_DNA_bind PF01726.16 CCM02443.1 - 0.093 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain zf-RING_UBOX PF13445.6 CCM02443.1 - 0.51 10.4 7.0 0.079 13.0 2.4 2.1 2 0 0 2 2 2 0 RING-type zinc-finger Prok-RING_4 PF14447.6 CCM02443.1 - 1.2 9.0 9.0 0.058 13.3 1.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCM02443.1 - 8.6 6.3 7.4 1.4 8.8 0.3 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 CCM02444.1 - 2.4e-41 141.8 0.0 2.5e-40 138.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02444.1 - 3.7e-20 72.3 0.0 1.3e-19 70.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM02444.1 - 0.034 14.1 0.2 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCM02444.1 - 0.05 12.5 0.0 0.095 11.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain ParA PF10609.9 CCM02445.1 - 5.5e-96 320.8 0.0 6.5e-96 320.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCM02445.1 - 1e-08 35.3 0.0 1.8e-08 34.5 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CCM02445.1 - 1.2e-05 24.7 0.7 0.0021 17.3 0.1 2.8 2 1 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.6 CCM02445.1 - 0.00012 22.1 0.1 0.0014 18.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 CCM02445.1 - 0.0013 18.2 0.0 0.0041 16.6 0.0 1.8 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 CCM02445.1 - 0.0097 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCM02445.1 - 0.017 15.0 0.1 0.045 13.6 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase Fer4_NifH PF00142.18 CCM02445.1 - 0.059 12.8 0.0 1.5 8.2 0.0 2.5 2 1 1 3 3 3 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family NB-ARC PF00931.22 CCM02445.1 - 0.077 12.2 0.1 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain YjeF_N PF03853.15 CCM02445.1 - 0.14 12.0 0.0 4 7.3 0.0 2.2 2 0 0 2 2 2 0 YjeF-related protein N-terminus VirE PF05272.11 CCM02445.1 - 0.18 11.5 0.1 0.3 10.8 0.1 1.2 1 0 0 1 1 1 0 Virulence-associated protein E MeaB PF03308.16 CCM02445.1 - 0.18 10.7 0.1 0.27 10.2 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Pkinase PF00069.25 CCM02446.1 - 1.7e-69 234.1 0.0 2.6e-69 233.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02446.1 - 1.4e-35 122.9 0.0 2.5e-35 122.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCM02446.1 - 0.00061 18.8 0.0 0.00096 18.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCM02446.1 - 0.00077 18.9 0.0 0.0019 17.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CCM02446.1 - 0.0044 16.4 0.1 0.0072 15.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Tma16 PF11176.8 CCM02447.1 - 1.1e-43 148.6 6.1 1.4e-43 148.2 6.1 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 Fructosamin_kin PF03881.14 CCM02448.1 - 0.24 10.6 0.1 0.37 9.9 0.1 1.2 1 0 0 1 1 1 0 Fructosamine kinase PAT1 PF09770.9 CCM02449.1 - 1.4e-109 367.7 47.1 5.5e-108 362.4 47.1 2.7 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 hDGE_amylase PF14701.6 CCM02450.1 - 1.7e-158 528.3 0.0 2.2e-158 527.9 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 CCM02450.1 - 3.8e-116 388.2 0.0 5.3e-116 387.7 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 CCM02450.1 - 1.1e-81 274.3 0.0 1.6e-81 273.7 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 CCM02450.1 - 4.1e-20 71.7 0.0 9.1e-20 70.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme SCA7 PF08313.12 CCM02451.1 - 6.1e-29 99.7 0.2 1.8e-28 98.2 0.2 1.8 1 0 0 1 1 1 1 SCA7, zinc-binding domain zf_C2H2_13 PF18508.1 CCM02451.1 - 0.0005 19.6 0.7 0.00089 18.8 0.7 1.4 1 0 0 1 1 1 1 Zinc finger domain zf_UBZ PF18439.1 CCM02451.1 - 0.076 12.6 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger Malt_amylase_C PF16657.5 CCM02453.1 - 0.055 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain Peptidase_C48 PF02902.19 CCM02457.1 - 3.2e-34 118.7 0.1 1.9e-20 73.6 0.1 2.4 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain SKN1 PF03935.15 CCM02458.1 - 1.5e-200 666.8 10.9 1.9e-200 666.5 10.9 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) DUF5613 PF18467.1 CCM02458.1 - 0.08 13.4 0.3 0.5 10.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5613) Mur_ligase_M PF08245.12 CCM02459.1 - 2.7e-07 30.8 0.0 4.5e-05 23.5 0.0 2.9 2 1 0 2 2 2 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CCM02459.1 - 0.017 15.4 0.0 0.23 11.7 0.0 2.5 2 0 0 2 2 2 0 Mur ligase family, glutamate ligase domain RHS_repeat PF05593.14 CCM02460.1 - 2.2e-18 66.3 40.4 0.00028 21.3 0.4 13.1 11 2 2 13 13 13 7 RHS Repeat VCBS PF13517.6 CCM02460.1 - 2.1e-08 34.6 13.6 0.00062 20.3 0.3 5.6 4 0 0 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 CCM02460.1 - 5.7e-06 25.8 24.3 0.0026 17.2 0.6 7.7 6 2 1 7 7 7 2 Insecticide toxin TcdB middle/N-terminal region RHS PF03527.14 CCM02460.1 - 0.00035 20.2 0.2 0.0013 18.4 0.2 2.1 1 0 0 1 1 1 1 RHS protein FG-GAP PF01839.23 CCM02460.1 - 0.052 13.7 16.9 0.095 12.9 3.2 3.5 3 0 0 3 3 3 0 FG-GAP repeat PucR PF07905.11 CCM02461.1 - 0.21 11.8 0.1 0.38 11.1 0.1 1.3 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family CVNH PF08881.10 CCM02462.1 - 9.4e-07 29.5 0.1 1.3e-06 29.0 0.1 1.2 1 0 0 1 1 1 1 CVNH domain ThiF PF00899.21 CCM02463.1 - 2.6e-32 112.1 0.6 5.7e-15 55.3 0.0 2.1 2 0 0 2 2 2 2 ThiF family Fungal_trans PF04082.18 CCM02464.1 - 1.1e-19 70.6 0.0 1.9e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM02464.1 - 3.3e-07 30.3 10.6 3.3e-07 30.3 10.6 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PPR_2 PF13041.6 CCM02465.1 - 0.003 17.7 0.0 0.015 15.5 0.0 2.2 2 0 0 2 2 2 1 PPR repeat family PPR_1 PF12854.7 CCM02465.1 - 0.12 12.1 0.0 0.4 10.4 0.0 2.0 1 0 0 1 1 1 0 PPR repeat PPR_3 PF13812.6 CCM02465.1 - 0.12 12.5 0.0 0.98 9.5 0.0 2.2 1 1 2 3 3 3 0 Pentatricopeptide repeat domain TPR_2 PF07719.17 CCM02465.1 - 0.21 11.8 0.9 3.6 7.9 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat GRASP55_65 PF04495.14 CCM02466.1 - 4.4e-58 195.5 0.0 1.9e-41 141.6 0.0 2.2 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 CCM02466.1 - 8.5e-05 22.8 0.0 0.93 9.9 0.0 3.3 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 CCM02466.1 - 0.008 16.0 0.2 0.045 13.6 0.0 2.3 3 0 0 3 3 3 1 PDZ domain BTB PF00651.31 CCM02467.1 - 4.6e-06 26.8 0.0 0.16 12.2 0.0 3.4 3 0 0 3 3 3 3 BTB/POZ domain MATH PF00917.26 CCM02467.1 - 0.00013 22.1 0.0 0.00031 20.9 0.0 1.6 1 0 0 1 1 1 1 MATH domain RRM_1 PF00076.22 CCM02468.1 - 1.7e-50 168.7 2.5 3.5e-18 65.2 0.1 4.8 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCM02468.1 - 1.1e-11 44.4 0.0 0.001 18.9 0.0 3.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif Suf PF05843.14 CCM02468.1 - 2e-06 28.0 0.5 0.34 10.9 0.2 3.5 3 1 0 3 3 3 2 Suppressor of forked protein (Suf) Nup35_RRM_2 PF14605.6 CCM02468.1 - 0.00025 21.0 0.0 0.96 9.5 0.0 3.3 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 CCM02468.1 - 0.0018 18.4 0.0 3.3 7.9 0.0 4.1 4 0 0 4 4 4 1 RNA recognition motif RRM_Rrp7 PF17799.1 CCM02468.1 - 0.0043 16.9 0.0 1 9.1 0.0 3.3 2 1 1 3 3 3 1 Rrp7 RRM-like N-terminal domain PHM7_cyt PF14703.6 CCM02468.1 - 0.011 16.0 0.3 3.9 7.7 0.0 3.9 5 0 0 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter TPR_19 PF14559.6 CCM02468.1 - 0.026 15.0 6.8 2.7 8.6 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCM02468.1 - 0.029 15.2 7.0 3.2 8.8 0.0 5.4 3 1 1 5 5 5 0 Tetratricopeptide repeat RRM_3 PF08777.11 CCM02468.1 - 0.041 13.9 0.0 34 4.5 0.0 3.5 3 0 0 3 3 3 0 RNA binding motif F-box-like PF12937.7 CCM02469.1 - 6.6e-14 51.5 1.8 1.2e-12 47.5 0.4 2.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM02469.1 - 0.0016 18.2 8.6 0.59 10.1 1.4 3.9 3 1 0 3 3 3 2 F-box domain FAD_binding_2 PF00890.24 CCM02470.1 - 1.4e-49 169.3 7.8 6.2e-43 147.4 0.1 2.0 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 CCM02470.1 - 2.1e-08 33.9 1.6 0.00012 21.6 1.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM02470.1 - 5.4e-06 25.8 1.5 0.042 13.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCM02470.1 - 1.1e-05 24.7 7.3 0.00056 19.1 1.5 3.2 3 0 0 3 3 3 2 Glucose inhibited division protein A DAO PF01266.24 CCM02470.1 - 1.3e-05 25.0 6.8 1.3e-05 25.0 6.8 2.7 2 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CCM02470.1 - 3.6e-05 22.7 1.3 0.094 11.4 0.3 2.7 3 0 0 3 3 3 2 HI0933-like protein GMC_oxred_N PF00732.19 CCM02470.1 - 5.2e-05 22.8 0.0 0.027 13.9 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase NAD_binding_8 PF13450.6 CCM02470.1 - 0.0026 17.9 2.9 0.0033 17.6 0.9 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCM02470.1 - 0.033 13.4 0.1 0.097 11.9 0.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM02470.1 - 0.096 13.3 0.8 16 6.1 0.3 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCM02470.1 - 0.23 10.5 0.5 2.1 7.3 0.4 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein CVNH PF08881.10 CCM02471.1 - 1e-16 61.5 2.4 1.2e-16 61.2 2.4 1.1 1 0 0 1 1 1 1 CVNH domain Abhydrolase_6 PF12697.7 CCM02472.1 - 2.5e-05 25.0 0.0 6.6e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Nab2 PF11517.8 CCM02473.1 - 0.14 12.5 0.0 4.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Abhydrolase_6 PF12697.7 CCM02474.1 - 1.6e-06 28.9 0.0 3.2e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family TMEM154 PF15102.6 CCM02475.1 - 0.0057 16.6 0.2 0.016 15.1 0.2 1.7 1 0 0 1 1 1 1 TMEM154 protein family DUF4690 PF15756.5 CCM02475.1 - 0.92 10.2 6.5 0.17 12.5 1.9 2.2 2 0 0 2 2 2 0 Small Novel Rich in Cartilage mRNA_triPase PF02940.15 CCM02476.1 - 2.3e-49 168.1 0.0 2.8e-49 167.8 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain E1_dh PF00676.20 CCM02477.1 - 7.2e-81 271.4 0.0 9.2e-81 271.1 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component WD40 PF00400.32 CCM02480.1 - 2.8e-24 84.9 5.8 2.1e-07 31.5 0.8 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02480.1 - 4.7e-05 23.6 0.5 0.68 10.3 0.1 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 CCM02480.1 - 0.0013 18.5 2.3 0.73 9.5 0.2 3.1 1 1 2 3 3 3 2 Lipoprotein LpqB beta-propeller domain NACHT PF05729.12 CCM02480.1 - 0.0038 17.2 3.3 0.016 15.1 0.3 2.3 1 1 1 2 2 2 1 NACHT domain Nup160 PF11715.8 CCM02480.1 - 0.041 12.5 0.0 2.7 6.5 0.0 2.5 3 0 0 3 3 3 0 Nucleoporin Nup120/160 CHAP PF05257.16 CCM02480.1 - 0.22 12.2 3.5 2.8 8.6 0.4 3.0 1 1 1 2 2 2 0 CHAP domain Sugar_tr PF00083.24 CCM02481.1 - 7.5e-27 94.3 7.6 9.5e-27 93.9 7.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Pox_I5 PF04713.12 CCM02481.1 - 0.007 16.4 0.2 0.007 16.4 0.2 1.8 2 0 0 2 2 2 1 Poxvirus protein I5 PhyH PF05721.13 CCM02483.1 - 2.5e-06 27.9 0.1 0.009 16.3 0.0 2.4 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Mit_KHE1 PF10173.9 CCM02485.1 - 3.2e-54 183.9 0.2 4.2e-54 183.5 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related BCD PF15461.6 CCM02485.1 - 0.12 11.8 0.3 0.18 11.3 0.3 1.1 1 0 0 1 1 1 0 Beta-carotene 15,15'-dioxygenase F-box-like PF12937.7 CCM02486.1 - 4.2e-07 29.7 0.4 1.2e-06 28.2 0.4 1.9 1 0 0 1 1 1 1 F-box-like AAA PF00004.29 CCM02487.1 - 5.2e-08 33.4 0.1 2.5e-05 24.7 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCM02487.1 - 2.1e-06 27.8 0.2 0.00048 20.1 0.0 2.6 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 CCM02487.1 - 0.0024 18.3 0.0 0.0074 16.7 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CCM02487.1 - 0.048 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 CCM02487.1 - 0.086 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain T2SSE PF00437.20 CCM02487.1 - 0.088 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 CCM02487.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 CCM02487.1 - 0.18 11.8 0.0 0.57 10.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Cupin_8 PF13621.6 CCM02488.1 - 3.3e-58 197.4 0.0 5e-58 196.8 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 CCM02488.1 - 0.00022 21.6 0.1 0.00071 20.0 0.1 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 CCM02488.1 - 0.079 12.7 0.2 0.24 11.1 0.1 1.8 2 0 0 2 2 2 0 Cupin domain Ribosomal_L7Ae PF01248.26 CCM02489.1 - 9.5e-25 86.2 0.9 2.1e-24 85.1 0.9 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Histone_HNS PF00816.21 CCM02489.1 - 3.6 8.5 9.7 2.9 8.8 2.9 2.5 2 1 0 2 2 2 0 H-NS histone family HlyE PF06109.13 CCM02490.1 - 0.026 13.8 0.3 0.066 12.5 0.2 1.7 1 1 0 1 1 1 0 Haemolysin E (HlyE) DUF5624 PF18538.1 CCM02490.1 - 0.075 13.1 0.2 0.23 11.5 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) BLOC1_2 PF10046.9 CCM02490.1 - 0.14 12.4 3.6 0.89 9.9 0.4 3.0 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0184 PF03670.13 CCM02490.1 - 0.42 11.0 4.0 7.3 7.1 2.4 3.5 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0184) NPV_P10 PF05531.12 CCM02490.1 - 0.46 11.0 9.9 35 4.9 0.6 4.5 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Lectin_N PF03954.14 CCM02490.1 - 0.76 9.5 3.8 0.46 10.2 0.6 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF5517 PF17639.2 CCM02490.1 - 1.8 8.9 7.3 9.8 6.6 0.3 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5517) RFX_DNA_binding PF02257.15 CCM02491.1 - 9.6e-28 96.6 0.1 1.9e-27 95.7 0.1 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain NuDC PF16273.5 CCM02491.1 - 0.079 13.5 1.0 0.15 12.6 1.0 1.4 1 0 0 1 1 1 0 Nuclear distribution C domain Metallophos PF00149.28 CCM02492.1 - 1.3e-07 32.3 0.0 2.5e-07 31.4 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SpoIIP PF07454.11 CCM02493.1 - 0.0068 15.9 0.4 0.011 15.2 0.4 1.3 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) AMP-binding PF00501.28 CCM02494.1 - 4e-41 141.0 0.0 5.7e-41 140.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CCM02494.1 - 1.5e-07 31.2 1.1 3.8e-07 29.9 1.1 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CCM02494.1 - 0.0013 19.6 0.1 0.0026 18.7 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain UQ_con PF00179.26 CCM02495.1 - 1.5e-37 128.4 0.1 1.8e-37 128.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme FmiP_Thoc5 PF09766.9 CCM02496.1 - 6.7e-38 130.9 12.5 8.2e-38 130.6 12.5 1.0 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Radial_spoke_3 PF06098.11 CCM02496.1 - 0.0043 16.4 3.5 0.0043 16.4 3.5 1.6 2 0 0 2 2 2 1 Radial spoke protein 3 Mod_r PF07200.13 CCM02496.1 - 0.0049 17.0 7.5 0.0078 16.3 3.6 2.1 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein DUF948 PF06103.11 CCM02496.1 - 0.0078 16.4 3.1 0.17 12.2 1.4 2.3 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) SKA2 PF16740.5 CCM02496.1 - 0.012 15.4 8.1 1.1 9.1 0.0 2.7 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Syntaxin PF00804.25 CCM02496.1 - 0.02 14.6 5.1 1.8 8.2 0.1 2.2 2 0 0 2 2 2 0 Syntaxin DUF4570 PF15134.6 CCM02496.1 - 0.031 14.3 2.2 0.031 14.3 2.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) T3SSipB PF16535.5 CCM02496.1 - 0.047 14.2 3.8 0.047 14.2 0.9 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB DUF4446 PF14584.6 CCM02496.1 - 0.18 11.8 5.3 0.23 11.5 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) TssO PF17561.2 CCM02496.1 - 0.26 11.4 5.5 0.098 12.8 2.0 1.8 2 0 0 2 2 2 0 Type VI secretion system, TssO FAM76 PF16046.5 CCM02496.1 - 0.52 9.6 5.5 0.73 9.1 5.5 1.1 1 0 0 1 1 1 0 FAM76 protein CREPT PF16566.5 CCM02496.1 - 0.79 9.9 9.0 0.15 12.2 3.4 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1664 PF07889.12 CCM02496.1 - 2.7 8.1 6.0 4 7.5 2.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 CCM02496.1 - 7.5 5.8 11.6 1.2 8.4 4.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) G6PD_C PF02781.16 CCM02497.1 - 1.2e-111 372.6 0.0 1.5e-111 372.3 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CCM02497.1 - 5.3e-57 193.3 0.0 8e-57 192.7 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain G-alpha PF00503.20 CCM02500.1 - 3.1e-97 325.9 0.0 3.8e-97 325.6 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCM02500.1 - 1.6e-10 40.7 0.0 4.8e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_29 PF13555.6 CCM02500.1 - 0.0086 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Roc PF08477.13 CCM02500.1 - 0.024 14.8 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CCM02500.1 - 0.054 13.3 0.1 4.8 6.9 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 CCM02500.1 - 0.13 11.6 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family La PF05383.17 CCM02501.1 - 0.00011 22.2 0.3 0.00018 21.5 0.3 1.3 1 0 0 1 1 1 1 La domain adh_short PF00106.25 CCM02502.1 - 2.4e-20 72.8 0.1 6.3e-15 55.1 0.0 2.7 2 1 1 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM02502.1 - 1.6e-08 34.4 0.0 3.2e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM02502.1 - 5.6e-08 32.9 0.0 8.9e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM02502.1 - 3.2e-05 23.5 0.0 4.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CCM02502.1 - 0.00043 20.5 0.0 0.00073 19.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 CCM02502.1 - 0.0021 17.5 0.0 0.0028 17.1 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCM02502.1 - 0.025 14.5 0.1 0.046 13.6 0.1 1.5 1 1 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 CCM02502.1 - 0.036 13.6 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family ADH_zinc_N PF00107.26 CCM02502.1 - 0.048 13.6 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase NAD_binding_4 PF07993.12 CCM02502.1 - 0.063 12.4 0.0 0.091 11.9 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein 3HCDH_N PF02737.18 CCM02502.1 - 0.079 12.8 0.2 0.15 11.9 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 CCM02502.1 - 0.15 11.1 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain 2-Hacid_dh_C PF02826.19 CCM02502.1 - 0.19 11.1 0.1 0.33 10.3 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_hydro_16 PF00722.21 CCM02503.1 - 2.2e-05 24.0 0.0 4.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF883 PF05957.13 CCM02504.1 - 0.0072 16.9 12.7 0.0077 16.8 3.9 3.0 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF883) DUF5427 PF10310.9 CCM02504.1 - 0.31 9.9 13.7 0.38 9.6 13.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) ATP19 PF11022.8 CCM02505.1 - 3.8e-07 30.4 0.4 4.7e-07 30.1 0.4 1.2 1 0 0 1 1 1 1 ATP synthase subunit K TPD52 PF04201.15 CCM02506.1 - 0.0083 15.8 1.3 0.87 9.2 0.1 2.5 2 0 0 2 2 2 2 Tumour protein D52 family PKcGMP_CC PF16808.5 CCM02506.1 - 0.12 12.3 1.2 0.24 11.3 1.2 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Cytomega_UL20A PF05984.12 CCM02506.1 - 4 7.8 6.7 6.2 7.2 2.5 2.6 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein FA_desaturase PF00487.24 CCM02507.1 - 9.6e-14 51.8 28.1 1.8e-13 51.0 28.1 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCM02507.1 - 1.6e-13 50.6 0.1 2.9e-13 49.8 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF2034 PF10356.9 CCM02508.1 - 5.4e-14 52.0 0.3 5.8e-11 42.2 0.5 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 CCM02508.1 - 0.0019 18.2 0.1 0.0076 16.3 0.1 1.9 1 1 0 1 1 1 1 Restriction endonuclease Transp_cyt_pur PF02133.15 CCM02509.1 - 3.4e-37 128.3 31.3 4e-36 124.7 31.3 1.9 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin OCC1 PF15506.6 CCM02511.1 - 0.19 11.9 0.1 0.31 11.2 0.1 1.3 1 0 0 1 1 1 0 OCC1 family ZapB PF06005.12 CCM02512.1 - 0.017 15.6 0.3 0.031 14.7 0.3 1.4 1 0 0 1 1 1 0 Cell division protein ZapB CsbD PF05532.12 CCM02515.1 - 4.2e-13 49.0 10.9 3.3e-08 33.3 2.3 2.0 1 1 1 2 2 2 2 CsbD-like CsbD PF05532.12 CCM02516.1 - 7.8e-17 60.9 10.5 3.2e-09 36.6 1.3 2.1 1 1 1 2 2 2 2 CsbD-like F-box-like PF12937.7 CCM02517.1 - 1.4e-08 34.5 0.1 6e-08 32.4 0.1 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM02517.1 - 0.0086 15.9 1.2 3.2 7.7 0.3 3.3 2 1 0 2 2 2 2 F-box domain Pkinase_Tyr PF07714.17 CCM02518.1 - 5.9e-46 156.8 0.0 5.3e-27 94.7 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CCM02518.1 - 3e-36 125.2 0.0 2.3e-34 119.0 0.0 2.9 2 1 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 CCM02518.1 - 0.00027 20.4 0.0 0.00061 19.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM02518.1 - 0.00029 20.5 0.1 0.0014 18.2 0.0 2.0 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 CCM02518.1 - 0.0058 16.6 0.2 0.023 14.6 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF5385 PF17359.2 CCM02518.1 - 0.022 14.3 0.1 0.045 13.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) BTB PF00651.31 CCM02519.1 - 4.5e-09 36.5 0.0 7.8e-08 32.5 0.0 2.2 1 1 0 1 1 1 1 BTB/POZ domain MFS_1 PF07690.16 CCM02520.1 - 1e-30 106.9 30.1 4e-30 104.9 31.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF998 PF06197.13 CCM02520.1 - 0.004 16.8 21.3 0.048 13.3 4.2 3.6 2 2 1 3 3 3 2 Protein of unknown function (DUF998) Trp_oprn_chp PF09534.10 CCM02520.1 - 0.01 15.6 0.7 2 8.2 0.2 2.9 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) MMPL PF03176.15 CCM02520.1 - 0.087 11.7 5.5 1.6 7.6 1.6 2.3 2 0 0 2 2 2 0 MMPL family BCS1_N PF08740.11 CCM02522.1 - 6.2e-31 107.8 7.8 9.5e-31 107.2 7.8 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CCM02522.1 - 1.4e-12 48.1 0.0 3.4e-12 46.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM02522.1 - 0.0001 22.7 0.1 0.00032 21.1 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CCM02522.1 - 0.00091 19.0 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 CCM02522.1 - 0.0064 15.7 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 CCM02522.1 - 0.0086 15.8 0.0 0.042 13.6 0.0 2.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 CCM02522.1 - 0.011 15.7 0.1 0.087 12.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CCM02522.1 - 0.014 15.6 0.1 0.086 13.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CCM02522.1 - 0.031 14.1 0.7 0.26 11.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 CCM02522.1 - 0.034 13.9 0.3 0.76 9.5 0.0 2.7 2 1 1 3 3 3 0 AAA domain AAA_33 PF13671.6 CCM02522.1 - 0.042 14.0 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCM02522.1 - 0.042 14.4 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCM02522.1 - 0.057 12.7 0.0 0.32 10.3 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin ABC_tran PF00005.27 CCM02522.1 - 0.069 13.7 0.0 0.22 12.0 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CCM02522.1 - 0.072 13.4 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 CCM02522.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 CCM02522.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM02522.1 - 0.16 11.9 0.1 0.35 10.8 0.1 1.6 1 0 0 1 1 1 0 NACHT domain TIP49 PF06068.13 CCM02522.1 - 0.19 10.9 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain zf-MYND PF01753.18 CCM02523.1 - 0.049 13.7 16.6 0.15 12.2 16.6 1.8 1 1 0 1 1 1 0 MYND finger BCS1_N PF08740.11 CCM02524.1 - 1.9e-37 129.1 1.5 3.3e-37 128.3 1.5 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CCM02524.1 - 3.9e-15 56.4 0.0 2.3e-14 53.9 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCM02524.1 - 0.00081 19.2 0.0 0.017 14.9 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 CCM02524.1 - 0.0091 15.2 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 CCM02524.1 - 0.0096 16.3 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ATPase PF06745.13 CCM02524.1 - 0.088 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 CCM02524.1 - 0.15 12.2 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CCM02524.1 - 0.19 12.1 0.0 0.4 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pantoate_ligase PF02569.15 CCM02526.1 - 6.2e-88 294.5 0.0 7.2e-88 294.2 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Ifi-6-16 PF06140.13 CCM02528.1 - 4.5e-05 23.3 3.1 4.5e-05 23.3 3.1 2.6 2 1 0 2 2 2 1 Interferon-induced 6-16 family DUF1798 PF08807.10 CCM02528.1 - 0.12 12.6 0.0 28 4.9 0.0 3.2 3 1 0 3 3 3 0 Bacterial domain of unknown function (DUF1798) Osmo_CC PF08946.10 CCM02528.1 - 0.12 12.6 0.4 0.29 11.4 0.1 1.8 2 0 0 2 2 2 0 Osmosensory transporter coiled coil ApoLp-III PF07464.11 CCM02528.1 - 0.38 10.8 2.9 0.52 10.4 0.7 2.3 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Flagellin_N PF00669.20 CCM02528.1 - 2.7 8.1 6.3 2.6 8.2 3.6 2.0 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region Ifi-6-16 PF06140.13 CCM02530.1 - 1.1e-08 34.9 0.7 2.4e-08 33.8 0.7 1.5 1 0 0 1 1 1 1 Interferon-induced 6-16 family WD40 PF00400.32 CCM02532.1 - 1.3e-19 70.1 11.1 0.0071 17.2 0.5 5.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02532.1 - 0.0012 19.1 0.2 0.92 9.9 0.1 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM02532.1 - 0.0088 15.0 0.0 0.61 9.0 0.0 2.3 1 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SIR2 PF02146.17 CCM02533.1 - 4e-28 98.5 0.0 1.1e-27 97.1 0.0 1.7 1 1 0 1 1 1 1 Sir2 family CDC45 PF02724.14 CCM02535.1 - 9.2 4.4 13.3 14 3.8 13.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Methyltransf_16 PF10294.9 CCM02536.1 - 1.2e-17 64.2 0.0 1.9e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 CCM02536.1 - 0.0016 18.3 0.0 0.0043 16.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 CCM02536.1 - 0.0026 17.1 0.0 0.0045 16.3 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_12 PF08242.12 CCM02536.1 - 0.02 15.6 0.0 0.041 14.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CCM02536.1 - 0.044 13.3 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 CCM02536.1 - 0.1 13.3 0.0 0.3 11.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 CCM02536.1 - 0.19 11.4 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Cript PF10235.9 CCM02537.1 - 2.8e-05 24.6 1.5 4.3e-05 24.0 0.0 1.8 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT SNF2_N PF00176.23 CCM02538.1 - 1e-07 31.0 0.4 0.002 16.9 0.1 2.5 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM02538.1 - 2.7e-06 27.7 0.1 1.5e-05 25.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF3502 PF12010.8 CCM02538.1 - 0.051 14.2 0.0 0.3 11.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3502) zf-RING_5 PF14634.6 CCM02538.1 - 0.079 12.9 10.0 0.066 13.2 8.1 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 CCM02538.1 - 0.17 12.3 8.4 0.24 11.8 7.5 1.7 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 CCM02538.1 - 1.3 9.1 6.9 2.5 8.2 6.9 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 CCM02538.1 - 4.7 7.2 10.5 49 3.9 10.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CCM02538.1 - 5.2 7.0 8.5 12 5.9 8.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM02538.1 - 6.2 6.8 6.9 15 5.5 6.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DNA_methylase PF00145.17 CCM02539.1 - 1.5e-13 50.8 0.0 2.4e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase PAF PF15715.5 CCM02539.1 - 0.091 13.3 0.3 0.23 12.1 0.3 1.6 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Peptidase_S21 PF00716.17 CCM02540.1 - 0.97 9.1 10.5 2.4 7.7 10.6 1.6 2 0 0 2 2 2 0 Assemblin (Peptidase family S21) Zw10 PF06248.13 CCM02541.1 - 5e-23 81.5 0.0 4.2e-19 68.5 0.0 2.3 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 CCM02541.1 - 5e-08 32.9 0.0 1.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal Vps54_N PF10475.9 CCM02541.1 - 0.0046 16.3 0.1 0.02 14.2 0.0 1.9 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Allexi_40kDa PF05549.11 CCM02541.1 - 0.11 12.0 2.2 2 7.9 0.0 2.5 3 0 0 3 3 3 0 Allexivirus 40kDa protein Rep_fac_C PF08542.11 CCM02542.1 - 8.7e-21 74.1 0.0 2.2e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CCM02542.1 - 2.8e-17 63.4 0.0 4.5e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CCM02542.1 - 5.1e-15 55.6 0.0 3.7e-12 46.3 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CCM02542.1 - 3.3e-08 33.7 0.0 9.7e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 CCM02542.1 - 2e-07 30.9 0.0 6.5e-07 29.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCM02542.1 - 3.9e-06 26.8 0.2 0.00014 21.8 0.0 2.1 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 CCM02542.1 - 6.4e-06 25.5 0.0 9.2e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_assoc_2 PF16193.5 CCM02542.1 - 2.3e-05 24.6 0.1 9.8e-05 22.6 0.1 2.1 1 1 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 CCM02542.1 - 2.5e-05 24.3 0.1 5.3e-05 23.3 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM02542.1 - 8.8e-05 22.9 0.2 0.05 13.9 0.0 2.6 2 1 1 3 3 2 2 AAA domain DEAD PF00270.29 CCM02542.1 - 0.00016 21.5 0.3 0.00046 20.0 0.3 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase RuvB_N PF05496.12 CCM02542.1 - 0.00018 21.3 0.0 0.00038 20.2 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCM02542.1 - 0.00019 21.9 0.0 0.00049 20.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain DNA_pol3_delta PF06144.13 CCM02542.1 - 0.00021 21.1 0.0 0.00046 20.0 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 CCM02542.1 - 0.00046 20.5 0.3 0.22 11.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain ResIII PF04851.15 CCM02542.1 - 0.00048 20.2 0.0 0.0078 16.2 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_24 PF13479.6 CCM02542.1 - 0.00053 19.8 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CCM02542.1 - 0.00066 19.5 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCM02542.1 - 0.00076 19.5 0.1 0.0084 16.1 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CCM02542.1 - 0.0041 16.7 0.0 0.007 15.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Viral_helicase1 PF01443.18 CCM02542.1 - 0.0064 16.3 0.0 0.0097 15.7 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 CCM02542.1 - 0.0082 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 CCM02542.1 - 0.019 14.9 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 CCM02542.1 - 0.03 13.7 0.1 1.4 8.3 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein MCM PF00493.23 CCM02542.1 - 0.031 13.4 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Methyltransf_31 PF13847.6 CCM02542.1 - 0.042 13.6 0.1 0.11 12.3 0.1 1.7 1 1 1 2 2 2 0 Methyltransferase domain T2SSE PF00437.20 CCM02542.1 - 0.052 12.6 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PIF1 PF05970.14 CCM02542.1 - 0.1 11.8 0.0 3.7 6.6 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase AAA_18 PF13238.6 CCM02542.1 - 0.1 13.2 0.0 0.3 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CCM02542.1 - 0.12 11.8 0.0 0.41 10.0 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 CCM02542.1 - 0.15 11.6 0.0 0.62 9.6 0.0 2.1 2 1 0 2 2 1 0 AAA domain AAA_28 PF13521.6 CCM02542.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain ubiquitin PF00240.23 CCM02543.1 - 3.4e-34 116.4 0.5 3.4e-34 116.4 0.5 1.7 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 CCM02543.1 - 7.2e-26 90.1 1.4 7.2e-26 90.1 1.4 1.9 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 CCM02543.1 - 3.5e-16 58.8 0.6 7.9e-16 57.7 0.6 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CCM02543.1 - 2.7e-05 24.5 0.3 0.00014 22.2 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CCM02543.1 - 0.00029 20.9 0.5 0.00065 19.8 0.5 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 CCM02543.1 - 0.0073 16.2 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CCM02543.1 - 0.0075 16.6 1.1 0.012 15.9 0.1 1.8 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 CCM02543.1 - 0.008 16.7 0.8 0.011 16.3 0.8 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.21 CCM02543.1 - 0.018 15.3 0.5 0.029 14.6 0.5 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Ubiquitin_4 PF18036.1 CCM02543.1 - 0.02 14.9 1.1 5.9 7.0 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-like domain DUF4925 PF16272.5 CCM02543.1 - 0.026 14.0 0.2 0.036 13.5 0.2 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4925) DUF971 PF06155.12 CCM02543.1 - 0.13 12.9 0.2 0.27 11.9 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF971) SHR3_chaperone PF08229.11 CCM02546.1 - 1.9e-12 46.5 0.1 2.4e-12 46.2 0.1 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 RhoGAP PF00620.27 CCM02547.1 - 1.7e-41 141.6 0.0 3.2e-41 140.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 CCM02547.1 - 2.8e-16 59.9 0.0 9.5e-16 58.2 0.0 2.0 2 0 0 2 2 2 1 PH domain PX PF00787.24 CCM02547.1 - 2e-06 27.8 0.0 4e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 PX domain UAA PF08449.11 CCM02549.1 - 1.4e-76 257.6 9.0 1.6e-76 257.4 9.0 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCM02549.1 - 9.8e-07 29.0 23.0 0.00014 22.0 4.2 2.9 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 CCM02549.1 - 2.2e-05 23.8 9.3 0.00023 20.5 0.8 2.3 2 0 0 2 2 2 2 Purine nucleobase transmembrane transport DUF2569 PF10754.9 CCM02549.1 - 0.0064 16.9 1.5 0.0064 16.9 1.5 2.4 1 1 2 3 3 3 1 Protein of unknown function (DUF2569) CRT-like PF08627.10 CCM02549.1 - 0.033 13.1 1.7 0.035 13.0 0.2 1.8 1 1 1 2 2 2 0 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 CCM02549.1 - 0.048 13.0 5.5 0.45 9.8 1.0 2.3 2 0 0 2 2 2 0 Triose-phosphate Transporter family DUF2628 PF10947.8 CCM02549.1 - 0.11 12.8 2.4 0.13 12.6 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) DUF4173 PF13777.6 CCM02549.1 - 0.7 9.3 9.1 0.022 14.2 2.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4173) Aim19 PF10315.9 CCM02549.1 - 0.92 9.8 9.9 0.11 12.8 4.2 2.4 3 1 0 3 3 3 0 Altered inheritance of mitochondria protein 19 Pkinase PF00069.25 CCM02550.1 - 9e-65 218.7 0.1 1.7e-64 217.8 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02550.1 - 1.5e-36 126.0 0.0 2.2e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM02550.1 - 2.4e-09 36.9 0.0 4e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCM02550.1 - 0.00021 20.2 2.7 0.00033 19.5 0.2 2.3 2 1 1 3 3 3 1 Fungal protein kinase APH PF01636.23 CCM02550.1 - 0.0021 18.0 0.6 0.0049 16.8 0.6 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCM02550.1 - 0.003 17.0 3.0 0.0073 15.7 0.3 2.6 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCM02550.1 - 0.028 13.4 0.2 0.042 12.8 0.2 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Guanylate_kin PF00625.21 CCM02551.1 - 3.5e-66 222.3 0.0 4.3e-66 222.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 CCM02551.1 - 1.9e-09 38.1 0.0 3.4e-09 37.3 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CCM02551.1 - 8.6e-06 26.0 0.0 5.4e-05 23.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCM02551.1 - 0.00018 21.8 0.0 0.00062 20.0 0.0 1.8 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCM02551.1 - 0.00078 19.4 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 CCM02551.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 CCM02551.1 - 0.0018 18.2 0.0 0.0046 16.9 0.0 1.6 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 CCM02551.1 - 0.0036 17.3 0.1 0.013 15.5 0.0 1.9 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCM02551.1 - 0.0041 17.5 0.0 0.0099 16.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 CCM02551.1 - 0.0042 17.6 0.0 0.0046 17.5 0.0 1.5 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 CCM02551.1 - 0.0044 17.6 0.4 0.025 15.1 0.3 2.2 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CCM02551.1 - 0.01 15.7 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 CCM02551.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 CCM02551.1 - 0.017 15.4 0.0 0.095 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CCM02551.1 - 0.018 15.0 0.0 0.071 13.0 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 CCM02551.1 - 0.018 14.8 0.0 0.4 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 CCM02551.1 - 0.026 14.4 0.0 0.72 9.7 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase NTPase_1 PF03266.15 CCM02551.1 - 0.032 14.1 0.0 0.07 13.0 0.0 1.4 1 1 0 1 1 1 0 NTPase AAA_7 PF12775.7 CCM02551.1 - 0.061 12.8 0.0 0.093 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 CCM02551.1 - 0.066 12.4 0.0 0.61 9.3 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 CCM02551.1 - 0.068 13.2 0.0 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Roc PF08477.13 CCM02551.1 - 0.095 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 CCM02551.1 - 0.12 11.6 0.0 0.29 10.3 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.29 CCM02551.1 - 0.12 12.8 0.1 0.33 11.4 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TRM PF02005.16 CCM02551.1 - 0.14 11.3 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Viral_helicase1 PF01443.18 CCM02551.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 CCM02551.1 - 0.18 11.3 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF1640 PF07798.11 CCM02552.1 - 2.8e-48 164.2 12.1 3.2e-48 164.1 12.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) SidE PF12252.8 CCM02552.1 - 0.058 10.9 9.4 0.069 10.7 9.4 1.0 1 0 0 1 1 1 0 Dot/Icm substrate protein FlaC_arch PF05377.11 CCM02552.1 - 0.068 13.6 1.4 0.068 13.6 1.4 2.7 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) KIAA1430 PF13879.6 CCM02552.1 - 0.11 13.3 9.3 0.14 12.9 9.2 1.3 1 1 0 1 1 1 0 KIAA1430 homologue COG5 PF10392.9 CCM02552.1 - 0.14 12.3 9.0 1 9.6 2.8 2.8 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Fungal_TACC PF12709.7 CCM02552.1 - 0.41 11.1 9.5 2 8.9 5.0 2.8 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Phage_lysis PF03245.13 CCM02552.1 - 0.6 10.2 11.1 0.22 11.7 3.7 2.1 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein Uso1_p115_C PF04871.13 CCM02552.1 - 0.75 10.2 13.1 0.074 13.4 4.7 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region BshC PF10079.9 CCM02552.1 - 1 8.0 9.6 1.5 7.5 9.6 1.4 1 1 0 1 1 1 0 Bacillithiol biosynthesis BshC Baculo_PEP_C PF04513.12 CCM02552.1 - 4.1 7.4 8.0 9.2 6.3 2.5 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CCDC23 PF15674.5 CCM02552.1 - 4.3 7.4 7.1 2.6 8.1 0.2 2.8 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 23 Fib_alpha PF08702.10 CCM02552.1 - 8.7 6.5 11.7 0.62 10.3 3.4 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family YabA PF06156.13 CCM02552.1 - 9.4 6.9 9.5 83 3.9 9.5 2.4 1 1 0 1 1 1 0 Initiation control protein YabA Mak16 PF04874.14 CCM02553.1 - 3.3e-28 98.2 12.3 3.3e-28 98.2 12.3 2.4 2 0 0 2 2 2 1 Mak16 protein C-terminal region Ribosomal_L28e PF01778.17 CCM02553.1 - 3.2e-16 60.1 0.1 7.1e-16 59.0 0.1 1.6 1 0 0 1 1 1 1 Ribosomal L28e protein family BUD22 PF09073.10 CCM02553.1 - 0.00026 20.5 13.8 0.00033 20.1 13.8 1.1 1 0 0 1 1 1 1 BUD22 TFIIF_alpha PF05793.12 CCM02553.1 - 0.012 14.2 21.5 0.018 13.7 21.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SAPS PF04499.15 CCM02553.1 - 0.13 11.0 5.2 0.17 10.6 5.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PYC_OADA PF02436.18 CCM02553.1 - 0.22 11.3 1.7 0.31 10.8 1.7 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain CDC45 PF02724.14 CCM02553.1 - 2.2 6.5 14.7 2.6 6.2 14.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 CCM02553.1 - 8 4.5 22.1 9.8 4.2 22.1 1.1 1 0 0 1 1 1 0 Nop14-like family FA_hydroxylase PF04116.13 CCM02554.1 - 1.7e-24 86.7 17.7 1.6e-22 80.3 9.1 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily DUF3561 PF12084.8 CCM02554.1 - 3.2 7.8 7.9 11 6.0 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) SRP68 PF16969.5 CCM02555.1 - 0.04 12.9 0.7 0.04 12.9 0.7 1.0 1 0 0 1 1 1 0 RNA-binding signal recognition particle 68 DASH_Hsk3 PF08227.11 CCM02555.1 - 0.31 11.4 9.6 0.15 12.4 7.1 1.8 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like Kei1 PF08552.11 CCM02557.1 - 2.2e-54 184.3 5.9 3.1e-54 183.8 5.9 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 DUF4199 PF13858.6 CCM02557.1 - 0.036 14.5 0.8 0.061 13.7 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) FixQ PF05545.11 CCM02557.1 - 0.32 11.0 0.2 0.32 11.0 0.2 2.7 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ IF4E PF01652.18 CCM02558.1 - 1.2e-52 177.9 0.0 1.5e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E TPT PF03151.16 CCM02559.1 - 1.4e-54 185.4 21.5 1.7e-54 185.2 21.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CCM02559.1 - 1.7e-10 40.6 21.1 2.2e-10 40.3 21.1 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCM02559.1 - 1.5e-09 38.1 34.1 3e-06 27.5 13.7 2.8 2 1 0 2 2 2 2 EamA-like transporter family DUF4536 PF15055.6 CCM02559.1 - 0.11 12.8 0.1 0.34 11.2 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) Sds3 PF08598.11 CCM02561.1 - 6.7e-07 29.5 0.0 1.2e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 Sds3-like DUF4410 PF14366.6 CCM02561.1 - 0.038 13.9 0.2 15 5.5 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4410) Smr PF01713.21 CCM02562.1 - 1.1e-08 35.3 0.0 3.7e-08 33.6 0.0 2.0 1 0 0 1 1 1 1 Smr domain DUF1771 PF08590.10 CCM02562.1 - 7.5e-05 23.0 5.0 0.00017 21.9 5.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) SAGA-Tad1 PF12767.7 CCM02562.1 - 0.054 13.2 0.5 0.23 11.2 0.1 2.1 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit SIR2 PF02146.17 CCM02564.1 - 1.6e-58 197.5 0.0 4.2e-58 196.2 0.0 1.7 2 0 0 2 2 2 1 Sir2 family DUF592 PF04574.13 CCM02564.1 - 0.00053 19.8 0.1 0.0056 16.5 0.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 CCM02564.1 - 0.011 15.5 0.1 6.6 6.5 0.2 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Chromo_shadow PF01393.19 CCM02567.1 - 6.2e-16 58.2 0.2 1.6e-13 50.5 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain RRM_1 PF00076.22 CCM02567.1 - 3.8e-15 55.5 0.0 6.9e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Chromo PF00385.24 CCM02567.1 - 3.9e-11 42.7 1.0 7.5e-11 41.8 0.1 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain RRM_3 PF08777.11 CCM02567.1 - 0.011 15.8 0.1 0.011 15.8 0.1 2.3 2 1 1 3 3 3 0 RNA binding motif RRM_5 PF13893.6 CCM02567.1 - 0.011 15.3 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sulfotransfer_3 PF13469.6 CCM02567.1 - 0.074 13.4 0.1 0.66 10.3 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase family ECR1_N PF14382.6 CCM02569.1 - 1.7e-16 59.7 0.1 3.2e-16 58.8 0.1 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 CCM02569.1 - 2e-13 50.5 0.1 3.4e-13 49.7 0.1 1.4 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 CCM02569.1 - 0.035 14.7 0.1 0.23 12.1 0.1 2.2 1 1 0 1 1 1 0 Exosome component EXOSC1/CSL4 NOA36 PF06524.12 CCM02570.1 - 3.8 6.8 5.2 4.7 6.4 5.2 1.1 1 0 0 1 1 1 0 NOA36 protein zf-TFIIIC PF12660.7 CCM02571.1 - 2.6e-20 72.3 0.1 1.1e-19 70.3 0.1 2.1 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex PET117 PF15786.5 CCM02572.1 - 5.4e-23 81.0 2.9 6.1e-23 80.9 2.9 1.0 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial UNC119_bdg PF15435.6 CCM02573.1 - 0.049 13.2 0.2 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 UNC119-binding protein C5orf30 homologue DUF2015 PF09435.10 CCM02574.1 - 5.6e-36 122.8 0.0 6.8e-36 122.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) RED_N PF07808.13 CCM02575.1 - 7.5e-17 61.7 2.6 7.5e-17 61.7 2.6 2.5 3 0 0 3 3 3 1 RED-like protein N-terminal region PDGF_N PF04692.13 CCM02575.1 - 0.77 10.6 0.1 0.77 10.6 0.1 3.3 4 0 0 4 4 4 0 Platelet-derived growth factor, N terminal region MBOAT PF03062.19 CCM02576.1 - 1.9e-29 103.1 11.7 2.2e-29 102.9 7.5 2.3 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Fumarate_red_D PF02313.17 CCM02576.1 - 2.3 8.4 7.6 0.36 10.9 2.8 2.1 2 0 0 2 2 2 0 Fumarate reductase subunit D DLH PF01738.18 CCM02577.1 - 3.2e-21 75.9 0.0 3.9e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family MMgT PF10270.9 CCM02577.1 - 3.4e-13 49.8 0.0 5.8e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Membrane magnesium transporter Abhydrolase_1 PF00561.20 CCM02577.1 - 0.0039 16.9 0.0 0.021 14.5 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 CCM02578.1 - 2.5e-24 86.1 0.0 2.9e-24 85.9 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CCM02578.1 - 0.00027 20.7 0.0 0.00078 19.2 0.0 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold DUF383 PF04063.14 CCM02579.1 - 3.6e-62 209.4 0.0 9e-62 208.1 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 CCM02579.1 - 5.5e-17 61.4 0.4 1.1e-16 60.4 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Spt20 PF12090.8 CCM02580.1 - 9.8e-16 58.1 0.2 2.6e-11 43.6 0.0 5.2 3 1 0 3 3 3 2 Spt20 family GATA PF00320.27 CCM02581.1 - 1.5e-13 50.1 3.4 2.5e-13 49.4 3.4 1.4 1 0 0 1 1 1 1 GATA zinc finger SAPS PF04499.15 CCM02581.1 - 0.1 11.4 0.6 0.14 10.9 0.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 CCM02581.1 - 0.71 8.6 3.7 0.99 8.1 3.7 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 CCM02581.1 - 1.1 9.0 3.7 1.6 8.5 3.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 CCM02581.1 - 2.4 7.0 5.5 3.2 6.6 5.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spt20 PF12090.8 CCM02581.1 - 6.6 6.3 23.8 13 5.4 23.8 1.4 1 0 0 1 1 1 0 Spt20 family DEAD PF00270.29 CCM02583.1 - 7.2e-46 156.1 0.0 1.5e-45 155.1 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM02583.1 - 6.7e-31 106.9 0.0 2.3e-30 105.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM02583.1 - 0.053 13.5 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCM02583.1 - 0.23 10.6 0.0 0.36 10.0 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase TPR_2 PF07719.17 CCM02584.1 - 6e-06 26.0 0.4 0.01 15.9 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM02584.1 - 0.00014 21.6 0.8 0.29 11.0 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM02584.1 - 0.008 16.7 0.5 0.023 15.2 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCM02584.1 - 0.074 13.3 0.2 0.79 10.1 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCM02584.1 - 0.42 11.4 1.8 8.8 7.2 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2183 PF09949.9 CCM02585.1 - 2.1e-26 92.1 0.0 5.2e-26 90.9 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) DLH PF01738.18 CCM02586.1 - 1.8e-21 76.7 0.0 2e-21 76.5 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CCM02586.1 - 0.0017 18.1 0.0 0.011 15.4 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold ADH_zinc_N PF00107.26 CCM02587.1 - 3.4e-30 104.7 0.4 5e-30 104.1 0.4 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM02587.1 - 2.1e-15 57.9 0.0 3.6e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM02587.1 - 9.7e-06 25.4 0.0 3e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CCM02587.1 - 0.039 13.4 0.3 0.06 12.8 0.3 1.2 1 0 0 1 1 1 0 short chain dehydrogenase DUF5353 PF17304.2 CCM02587.1 - 0.6 9.9 3.8 38 4.1 0.8 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5353) DLH PF01738.18 CCM02588.1 - 1e-18 67.7 0.0 1.2e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Arginosuc_synth PF00764.19 CCM02589.1 - 9.4e-118 393.9 0.0 7.2e-79 265.8 0.0 2.0 1 1 1 2 2 2 2 Arginosuccinate synthase QueC PF06508.13 CCM02589.1 - 4.5e-05 23.0 0.0 7.3e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 CCM02589.1 - 0.02 13.7 0.0 0.038 12.8 0.0 1.4 1 1 0 1 1 1 0 tRNA methyl transferase RTC4 PF14474.6 CCM02591.1 - 9.3e-26 90.4 0.0 1.9e-25 89.3 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain GvpL_GvpF PF06386.11 CCM02591.1 - 0.11 12.4 3.9 0.24 11.3 3.9 1.5 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF PTS_2-RNA PF01885.16 CCM02592.1 - 7.2e-61 205.4 0.0 1.1e-60 204.8 0.0 1.3 1 1 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family EspB_PE PF18625.1 CCM02593.1 - 0.035 14.6 0.1 0.082 13.4 0.1 1.6 1 0 0 1 1 1 0 ESX-1 secreted protein B PE domain Sec62 PF03839.16 CCM02594.1 - 0.21 11.1 0.6 6.7 6.1 0.0 2.7 2 0 0 2 2 2 0 Translocation protein Sec62 HD_3 PF13023.6 CCM02595.1 - 9.9e-13 48.3 2.0 2.2e-12 47.2 2.3 1.4 1 1 0 1 1 1 1 HD domain TPR_MLP1_2 PF07926.12 CCM02595.1 - 0.018 15.1 1.2 0.018 15.1 1.2 1.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4286 PF14114.6 CCM02595.1 - 0.025 15.1 0.6 0.046 14.2 0.2 1.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4286) AICARFT_IMPCHas PF01808.18 CCM02596.1 - 4.4e-87 292.3 0.0 5.8e-87 291.9 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CCM02596.1 - 4.7e-25 87.6 0.0 8.7e-25 86.7 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain Glutaredoxin PF00462.24 CCM02598.1 - 1.1e-16 60.8 0.0 2.2e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin DNA_pol_B PF00136.21 CCM02599.1 - 5.5e-117 391.3 0.0 7.7e-117 390.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 CCM02599.1 - 6.1e-62 208.7 0.2 1e-61 207.9 0.2 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 CCM02599.1 - 1.3e-28 100.2 0.0 2e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 CCM02599.1 - 1.2e-17 63.8 7.0 6.2e-17 61.4 7.0 2.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 CCM02599.1 - 0.022 13.6 0.0 0.047 12.6 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral AP3D1 PF06375.11 CCM02599.1 - 0.78 10.0 6.5 0.59 10.4 0.0 2.9 2 1 1 3 3 3 0 AP-3 complex subunit delta-1 Flavin_Reduct PF01613.18 CCM02600.1 - 1.7e-30 106.1 0.2 2.2e-30 105.8 0.2 1.1 1 0 0 1 1 1 1 Flavin reductase like domain MFS_1 PF07690.16 CCM02601.1 - 2.6e-34 118.7 36.3 2.6e-34 118.7 36.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 CCM02601.1 - 0.00012 20.6 3.8 0.00019 20.0 3.8 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector RabGAP-TBC PF00566.18 CCM02603.1 - 5.8e-37 127.4 0.0 9.3e-37 126.8 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 CCM02603.1 - 0.00012 22.0 0.0 0.00036 20.4 0.0 1.9 1 0 0 1 1 1 1 GRAM domain EF-hand_1 PF00036.32 CCM02603.1 - 0.00034 19.9 0.1 0.001 18.5 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CCM02603.1 - 0.00068 20.0 2.4 0.0014 19.1 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 CCM02603.1 - 0.00087 19.0 2.9 0.0013 18.4 0.5 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 CCM02603.1 - 0.03 13.8 0.2 0.16 11.5 0.1 2.3 2 0 0 2 2 2 0 EF hand SPARC_Ca_bdg PF10591.9 CCM02603.1 - 0.081 13.2 0.1 0.35 11.2 0.1 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region HEPN_Swt1 PF18731.1 CCM02603.1 - 0.15 12.4 1.0 0.52 10.7 0.2 2.2 2 0 0 2 2 2 0 Swt1-like HEPN WD40 PF00400.32 CCM02604.1 - 5.9e-39 131.4 19.5 2.5e-10 40.8 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02604.1 - 8.8e-16 58.0 1.6 0.0039 17.5 0.0 4.1 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCM02604.1 - 3.2e-06 26.7 0.6 0.0047 16.3 0.1 2.9 2 2 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 CCM02604.1 - 1.5e-05 24.1 0.5 0.013 14.5 0.0 2.8 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCM02604.1 - 0.00018 20.3 2.6 0.029 13.0 0.2 3.3 1 1 2 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 CCM02604.1 - 0.00029 20.8 0.1 0.031 14.2 0.1 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 CCM02604.1 - 0.0066 15.2 1.1 1.7 7.3 0.1 2.7 1 1 2 3 3 3 2 Nup133 N terminal like CAP_N PF01213.19 CCM02604.1 - 0.56 9.6 6.2 0.76 9.2 6.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 CCM02604.1 - 2.6 8.1 4.6 3.6 7.6 4.6 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator DIOX_N PF14226.6 CCM02605.1 - 5e-16 59.5 0.0 8.7e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM02605.1 - 2.8e-14 53.4 0.0 7.9e-14 52.0 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily SAICAR_synt PF01259.18 CCM02606.1 - 3.1e-97 325.1 0.0 4.2e-97 324.7 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase DNA_ligase_A_M PF01068.21 CCM02607.1 - 2.4e-24 86.1 0.0 4.9e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCM02607.1 - 4e-15 56.6 0.0 8.1e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 CCM02607.1 - 0.00078 19.8 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 RNA ligase WD40 PF00400.32 CCM02608.1 - 5.2e-62 204.3 36.8 9.2e-09 35.8 0.3 8.9 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02608.1 - 1.8e-22 79.4 0.4 0.00012 22.3 0.0 5.9 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCM02608.1 - 1.9e-10 40.1 1.9 3.2e-05 22.8 0.0 3.9 4 1 1 5 5 5 3 Nucleoporin Nup120/160 NLE PF08154.12 CCM02608.1 - 1.1e-09 38.6 0.0 2e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 CCM02608.1 - 0.0003 19.8 0.0 0.33 9.9 0.0 4.1 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 CCM02608.1 - 0.0067 15.2 0.1 1.2 7.7 0.0 3.0 4 0 0 4 4 4 1 Nup133 N terminal like PQQ_3 PF13570.6 CCM02608.1 - 0.054 14.0 1.3 4 8.1 1.0 3.5 3 0 0 3 3 3 0 PQQ-like domain RAB3GAP2_N PF14655.6 CCM02608.1 - 0.098 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus IKI3 PF04762.12 CCM02608.1 - 0.18 9.8 0.1 0.29 9.1 0.1 1.3 1 0 0 1 1 1 0 IKI3 family Pirin PF02678.16 CCM02609.1 - 4.8e-27 94.1 0.4 7.1e-27 93.5 0.4 1.2 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.11 CCM02609.1 - 4.7e-07 29.4 1.7 3.2e-05 23.6 0.7 2.3 2 0 0 2 2 2 2 Cupin domain Pirin_C_2 PF17954.1 CCM02609.1 - 4.8e-05 23.5 0.0 0.00042 20.4 0.0 2.4 2 1 0 2 2 2 1 Quercetinase C-terminal cupin domain Cupin_3 PF05899.12 CCM02609.1 - 0.019 14.7 0.3 0.64 9.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF861) MMR_HSR1 PF01926.23 CCM02610.1 - 1.1e-16 60.9 0.0 1.6e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCM02610.1 - 1.7e-06 28.2 0.0 0.0033 17.5 0.1 2.2 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.18 CCM02610.1 - 0.00082 18.9 0.1 0.0014 18.2 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CCM02610.1 - 0.001 18.5 0.0 0.0015 17.9 0.0 1.4 1 1 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 CCM02610.1 - 0.0034 17.3 0.1 0.016 15.1 0.0 2.0 2 1 0 2 2 2 1 RsgA GTPase Septin PF00735.18 CCM02610.1 - 0.024 13.9 0.0 0.61 9.3 0.0 2.3 1 1 0 1 1 1 0 Septin AAA_29 PF13555.6 CCM02610.1 - 0.024 14.4 0.0 0.071 12.9 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 CCM02610.1 - 0.054 13.4 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 CCM02610.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 NTPase YadA_anchor PF03895.15 CCM02611.1 - 0.042 13.9 0.3 4.2 7.5 0.0 2.5 2 0 0 2 2 2 0 YadA-like membrane anchor domain MFMR PF07777.11 CCM02611.1 - 0.051 14.1 0.1 2.3 8.8 0.1 2.3 2 0 0 2 2 2 0 G-box binding protein MFMR Glypican PF01153.19 CCM02612.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Glypican E1-E2_ATPase PF00122.20 CCM02613.1 - 3.2e-41 140.8 3.4 8.1e-41 139.5 3.4 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCM02613.1 - 4.8e-24 85.8 0.3 9.5e-24 84.9 0.3 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CCM02613.1 - 1.2e-07 32.0 0.2 5.8e-07 29.9 0.1 2.3 2 0 0 2 2 2 1 Heavy-metal-associated domain MKT1_C PF12246.8 CCM02615.1 - 2.5e-71 239.7 0.0 4.9e-71 238.8 0.0 1.5 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 CCM02615.1 - 5.8e-28 97.1 0.0 1.2e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 CCM02615.1 - 1.9e-08 34.7 0.0 4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CCM02615.1 - 0.00044 20.5 0.0 0.0011 19.3 0.0 1.7 1 0 0 1 1 1 1 XPG I-region VPS9 PF02204.18 CCM02617.1 - 3.3e-19 69.0 0.0 1.4e-15 57.3 0.0 2.3 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain DUF4373 PF14297.6 CCM02617.1 - 0.24 12.2 0.0 0.51 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4373) F-box-like PF12937.7 CCM02618.1 - 0.0094 15.8 0.5 0.024 14.5 0.5 1.8 1 0 0 1 1 1 1 F-box-like Fibin PF15819.5 CCM02618.1 - 0.68 9.7 1.8 0.63 9.8 0.1 1.7 2 0 0 2 2 2 0 Fin bud initiation factor homologue Opi1 PF08618.10 CCM02619.1 - 6.1e-104 348.6 8.9 4.7e-83 279.8 6.1 2.7 2 1 1 3 3 3 2 Transcription factor Opi1 Perilipin PF03036.16 CCM02619.1 - 0.0043 16.1 0.7 0.037 13.0 0.0 2.4 3 0 0 3 3 3 1 Perilipin family REF PF05755.12 CCM02619.1 - 0.0095 15.8 0.1 0.039 13.8 0.0 1.9 2 0 0 2 2 2 1 Rubber elongation factor protein (REF) APG17 PF04108.12 CCM02619.1 - 0.15 11.1 0.2 0.25 10.4 0.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Methuselah_N PF06652.12 CCM02619.1 - 0.18 11.7 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 Methuselah N-terminus GATA PF00320.27 CCM02620.1 - 4.2e-16 58.3 3.4 8.7e-16 57.2 3.4 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 CCM02620.1 - 0.15 11.6 1.2 0.32 10.5 1.2 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding ArfGap PF01412.18 CCM02620.1 - 0.26 11.4 0.2 0.51 10.4 0.2 1.4 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf HAUS6_N PF14661.6 CCM02621.1 - 1.6e-10 41.0 0.1 7.4e-06 25.7 0.1 2.6 3 0 0 3 3 3 2 HAUS augmin-like complex subunit 6 N-terminus PSK_trans_fac PF07704.11 CCM02621.1 - 2.6 8.8 6.8 7.7 7.3 1.4 3.6 4 0 0 4 4 4 0 Rv0623-like transcription factor VCBS PF13517.6 CCM02623.1 - 4.2e-14 52.9 21.1 2e-05 25.1 1.2 5.4 1 1 4 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_5 PF13202.6 CCM02623.1 - 0.0008 18.8 0.1 6.1 6.5 0.0 3.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CCM02623.1 - 0.0065 16.3 7.8 18 5.6 0.0 5.4 5 0 0 5 5 5 2 EF-hand domain DUF99 PF01949.16 CCM02623.1 - 0.14 11.6 0.6 47 3.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function DUF99 Peptidase_S49 PF01343.18 CCM02623.1 - 0.15 12.0 0.2 46 3.9 0.0 2.9 3 0 0 3 3 3 0 Peptidase family S49 Moricin PF06451.11 CCM02623.1 - 0.19 11.5 0.6 41 4.1 0.0 3.3 3 0 0 3 3 3 0 Moricin EF-hand_1 PF00036.32 CCM02623.1 - 1.8 8.3 7.8 45 3.9 0.1 4.7 5 0 0 5 5 5 0 EF hand MOZART1 PF12554.8 CCM02624.1 - 1.1e-23 82.8 0.5 1.7e-23 82.1 0.5 1.3 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated UQ_con PF00179.26 CCM02624.1 - 3.1e-18 65.8 0.1 8.7e-18 64.3 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme DOPA_dioxygen PF08883.11 CCM02625.1 - 2e-43 146.9 0.2 2.7e-43 146.5 0.2 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family PALP PF00291.25 CCM02626.1 - 3.5e-30 105.4 0.4 5.2e-30 104.9 0.4 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF1275 PF06912.11 CCM02627.1 - 8.4e-19 68.3 17.7 1.4e-18 67.6 17.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) GHMP_kinases_C PF08544.13 CCM02627.1 - 0.034 14.5 0.1 0.083 13.3 0.1 1.7 1 0 0 1 1 1 0 GHMP kinases C terminal Vps55 PF04133.14 CCM02627.1 - 0.5 10.3 4.9 3.1 7.8 0.1 3.2 1 1 0 2 2 2 0 Vacuolar protein sorting 55 DUF4149 PF13664.6 CCM02627.1 - 0.8 10.1 9.0 6.6 7.1 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) VID27_N PF17748.1 CCM02628.1 - 0.021 14.7 0.2 0.034 14.0 0.2 1.3 1 0 0 1 1 1 0 VID27 N-terminal region MFS_1 PF07690.16 CCM02629.1 - 2.1e-33 115.7 51.3 2.1e-33 115.7 51.3 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCM02629.1 - 6.7e-18 64.4 16.2 8.8e-18 64.0 15.1 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM02629.1 - 2.3e-12 46.5 23.1 4.5e-12 45.6 11.5 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter SRF-TF PF00319.18 CCM02631.1 - 5.5e-13 48.2 0.0 9.4e-13 47.4 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Sporozoite_P67 PF05642.11 CCM02631.1 - 8 4.4 12.0 0.2 9.7 2.2 2.2 2 0 0 2 2 2 0 Sporozoite P67 surface antigen VPS28 PF03997.12 CCM02633.1 - 6.4e-53 179.2 0.1 4.2e-33 114.6 0.0 3.0 1 1 2 3 3 3 3 VPS28 protein Cu-oxidase PF00394.22 CCM02634.1 - 1.2e-39 135.9 0.0 6.2e-38 130.4 0.0 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCM02634.1 - 2.9e-36 124.1 1.0 1.5e-34 118.6 0.3 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCM02634.1 - 1.4e-32 112.3 4.9 1.2e-31 109.3 0.0 3.6 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 CCM02635.1 - 4.4e-41 140.6 0.0 1e-37 129.7 0.0 2.5 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCM02635.1 - 2.5e-36 124.3 0.6 4.9e-25 87.8 0.1 4.2 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCM02635.1 - 1.2e-34 119.0 2.8 3.5e-33 114.3 0.0 3.1 3 0 0 3 3 3 1 Multicopper oxidase GLTP PF08718.11 CCM02636.1 - 6.1e-11 42.8 0.0 1.2e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF4451 PF14616.6 CCM02636.1 - 1.1e-06 28.8 4.3 1.7 8.9 0.1 4.2 4 0 0 4 4 4 3 Domain of unknown function (DUF4451) DUF4609 PF15382.6 CCM02636.1 - 0.057 13.3 0.2 0.18 11.7 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) Eapp_C PF10238.9 CCM02636.1 - 0.25 11.4 5.2 4.3 7.4 0.3 3.3 2 1 1 3 3 3 0 E2F-associated phosphoprotein HypA PF01155.19 CCM02636.1 - 9.8 6.2 6.1 33 4.5 0.4 3.0 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Pkinase PF00069.25 CCM02637.1 - 1.9e-62 211.0 0.0 2.2e-62 210.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02637.1 - 4e-18 65.6 0.0 5e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM02637.1 - 1.1e-08 35.3 0.0 2.6e-05 24.3 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM02637.1 - 7.8e-05 21.6 0.0 0.0026 16.6 0.0 2.6 3 0 0 3 3 3 1 Fungal protein kinase RIO1 PF01163.22 CCM02637.1 - 0.00062 19.4 0.1 0.0011 18.6 0.1 1.4 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 CCM02637.1 - 0.0027 17.3 0.0 0.0057 16.3 0.0 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase MA3 PF02847.17 CCM02637.1 - 0.0072 16.3 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 MA3 domain ABC1 PF03109.16 CCM02637.1 - 0.037 14.2 0.0 0.086 13.0 0.0 1.5 1 0 0 1 1 1 0 ABC1 family CDC4_D PF16856.5 CCM02637.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Cell division control protein 4 dimerisation domain DUF1679 PF07914.11 CCM02637.1 - 0.084 11.7 0.0 1 8.1 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) Fungal_trans PF04082.18 CCM02638.1 - 7.8e-12 44.8 0.0 1.4e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain G_path_suppress PF15991.5 CCM02638.1 - 1.2 9.2 12.8 2.2 8.3 12.8 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor Fungal_trans PF04082.18 CCM02639.1 - 8.4e-27 93.9 0.0 1.4e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HSBP1 PF06825.12 CCM02639.1 - 0.016 15.0 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Suf PF05843.14 CCM02640.1 - 0.29 11.1 3.2 0.39 10.7 3.2 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Rrn6 PF10214.9 CCM02640.1 - 3.4 6.1 14.2 4.4 5.7 14.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor NAM-associated PF14303.6 CCM02640.1 - 5.9 7.6 8.3 9.2 7.0 8.3 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Amidase PF01425.21 CCM02641.1 - 1.3e-107 360.5 0.5 1.7e-107 360.2 0.5 1.1 1 0 0 1 1 1 1 Amidase WD40 PF00400.32 CCM02642.1 - 2.2e-23 82.1 1.9 4.4e-07 30.5 0.1 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02642.1 - 7.4e-09 35.8 1.1 0.14 12.5 0.1 5.2 2 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCM02642.1 - 0.0058 16.0 0.0 0.14 11.5 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain Cytochrom_D1 PF02239.16 CCM02642.1 - 0.0096 14.5 2.0 0.077 11.5 0.0 2.8 3 1 1 4 4 4 2 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 CCM02642.1 - 0.014 14.4 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region DUF1604 PF07713.13 CCM02643.1 - 3.8e-36 122.8 0.5 3.8e-36 122.8 0.5 3.5 4 1 0 4 4 4 1 Protein of unknown function (DUF1604) G-patch PF01585.23 CCM02643.1 - 1.6e-06 27.9 0.2 5.3e-06 26.2 0.2 2.0 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CCM02643.1 - 0.61 10.2 0.0 0.61 10.2 0.0 4.4 6 0 0 6 6 6 0 G-patch domain AA_permease PF00324.21 CCM02644.1 - 1.5e-114 383.3 35.4 4.4e-114 381.7 35.4 1.6 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCM02644.1 - 7.3e-34 117.3 34.9 1.3e-33 116.5 34.8 1.4 1 1 0 1 1 1 1 Amino acid permease RhoGEF PF00621.20 CCM02646.1 - 2.3e-68 230.0 2.4 6.3e-34 117.8 0.1 2.3 2 0 0 2 2 2 2 RhoGEF domain CNH PF00780.22 CCM02646.1 - 2.6e-62 210.9 0.0 4.1e-62 210.3 0.0 1.2 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 CCM02646.1 - 9.7e-18 64.6 0.0 2.2e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 CCM02646.1 - 0.00013 21.9 0.0 0.00062 19.8 0.0 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_13 PF16652.5 CCM02646.1 - 0.055 13.3 0.0 0.61 9.9 0.0 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain Methyltransf_23 PF13489.6 CCM02647.1 - 5.3e-13 49.1 0.0 8.7e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM02647.1 - 7.1e-12 45.9 0.0 2.6e-11 44.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM02647.1 - 1.1e-10 42.1 0.0 3e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM02647.1 - 3.6e-08 33.9 0.0 1.4e-07 32.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM02647.1 - 2.7e-06 27.2 0.0 6.1e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CCM02647.1 - 0.029 13.9 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_24 PF13578.6 CCM02647.1 - 0.097 13.7 0.0 0.2 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF3060 PF11259.8 CCM02648.1 - 0.0027 17.3 8.4 0.0076 15.9 0.7 3.8 4 0 0 4 4 4 2 Protein of unknown function (DUF3060) CNH PF00780.22 CCM02649.1 - 5.4e-43 147.6 0.0 7.3e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 CNH domain PH_5 PF15405.6 CCM02649.1 - 1.8e-18 67.0 0.0 2.8e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CCM02649.1 - 0.11 13.0 0.0 0.36 11.4 0.0 2.0 1 1 0 1 1 1 0 PH domain Lipase_3 PF01764.25 CCM02650.1 - 2.3e-23 82.6 0.0 4e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCM02650.1 - 0.00012 22.7 0.1 0.00015 22.4 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM02650.1 - 0.0031 16.8 0.1 0.0046 16.2 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCM02650.1 - 0.052 13.2 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold VirJ PF06057.11 CCM02650.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF915 PF06028.11 CCM02650.1 - 0.13 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.13 CCM02650.1 - 0.16 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 CCM02651.1 - 5.6e-22 78.1 0.0 8e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCM02651.1 - 0.0029 18.2 0.2 0.0041 17.8 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM02651.1 - 0.0035 16.6 0.1 0.0052 16.1 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 CCM02651.1 - 0.014 14.9 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_8 PF06259.12 CCM02651.1 - 0.022 14.4 0.1 0.037 13.6 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Esterase PF00756.20 CCM02651.1 - 0.039 13.6 0.1 0.063 12.9 0.1 1.3 1 0 0 1 1 1 0 Putative esterase Flocculin PF00624.18 CCM02651.1 - 0.12 12.7 6.5 0.31 11.3 3.6 2.4 2 0 0 2 2 2 0 Flocculin repeat LIDHydrolase PF10230.9 CCM02651.1 - 0.16 11.5 0.1 0.24 10.9 0.1 1.1 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase CAP_GLY PF01302.25 CCM02652.1 - 1e-25 89.5 1.5 2.1e-25 88.5 1.5 1.6 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 CCM02652.1 - 8.5e-24 83.8 0.1 1.4e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 CCM02652.1 - 0.0026 17.5 0.1 0.057 13.2 0.0 2.6 2 1 0 2 2 2 1 Ubiquitin family AAA PF00004.29 CCM02653.1 - 5.8e-97 321.2 0.0 1.8e-47 161.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCM02653.1 - 3.7e-24 84.3 8.2 2.8e-12 46.2 0.3 3.1 3 0 0 3 3 2 2 AAA+ lid domain CDC48_N PF02359.18 CCM02653.1 - 2.6e-21 75.6 0.1 1.5e-20 73.2 0.1 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 CCM02653.1 - 3.5e-14 52.8 0.0 7.3e-06 25.8 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CCM02653.1 - 1.9e-13 50.9 0.0 1.6e-07 31.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CCM02653.1 - 6.7e-12 45.8 0.0 5.4e-06 26.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 CCM02653.1 - 9.9e-12 44.5 0.0 2.9e-11 43.0 0.0 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.14 CCM02653.1 - 1.6e-11 44.4 0.2 2.1e-05 24.5 0.1 3.7 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCM02653.1 - 6.4e-11 42.9 0.3 0.0021 18.5 0.0 4.4 3 2 1 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 CCM02653.1 - 2.6e-09 37.4 0.3 0.021 15.1 0.0 4.3 3 2 0 3 3 2 2 AAA domain TIP49 PF06068.13 CCM02653.1 - 3.9e-09 36.2 0.1 0.0014 17.9 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 CCM02653.1 - 3.5e-07 29.8 0.3 0.029 13.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CCM02653.1 - 4.2e-07 29.5 0.2 0.19 11.0 0.0 3.4 3 0 0 3 3 3 2 KaiC RNA_helicase PF00910.22 CCM02653.1 - 5.1e-07 30.1 0.0 0.022 15.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Vps4_C PF09336.10 CCM02653.1 - 5.6e-07 29.5 0.3 3.6e-05 23.7 0.0 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 CCM02653.1 - 8.8e-07 28.8 0.0 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 CCM02653.1 - 9e-07 29.5 0.0 0.041 14.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 CCM02653.1 - 1.2e-06 28.6 0.0 0.018 15.1 0.0 2.8 3 0 0 3 3 2 2 AAA domain Parvo_NS1 PF01057.17 CCM02653.1 - 3.7e-06 26.2 0.1 0.012 14.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 CCM02653.1 - 4.3e-06 26.4 0.1 0.021 14.3 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_25 PF13481.6 CCM02653.1 - 5.6e-06 26.1 0.3 1.3 8.6 0.0 3.4 2 1 0 3 3 3 2 AAA domain AAA_24 PF13479.6 CCM02653.1 - 7e-06 25.9 0.0 0.13 11.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain DUF815 PF05673.13 CCM02653.1 - 1.3e-05 24.5 0.0 0.0079 15.4 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CCM02653.1 - 1.4e-05 24.8 0.0 0.31 10.7 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.6 CCM02653.1 - 1.5e-05 25.3 0.0 0.11 12.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 CCM02653.1 - 2.1e-05 25.1 0.0 0.066 13.7 0.0 3.4 2 1 0 2 2 2 1 ABC transporter Bac_DnaA PF00308.18 CCM02653.1 - 3.3e-05 23.9 0.0 0.16 11.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_17 PF13207.6 CCM02653.1 - 0.00015 22.2 0.2 0.61 10.5 0.0 3.1 3 0 0 3 3 2 2 AAA domain TsaE PF02367.17 CCM02653.1 - 0.00015 21.7 0.0 0.33 10.9 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CCM02653.1 - 0.00018 21.5 0.2 2.4 8.0 0.0 3.8 3 1 0 3 3 3 2 ATPase domain predominantly from Archaea ResIII PF04851.15 CCM02653.1 - 0.00021 21.4 0.1 0.078 13.0 0.0 2.7 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 CCM02653.1 - 0.00021 20.8 0.5 0.47 9.9 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.11 CCM02653.1 - 0.00021 21.1 0.0 0.8 9.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 CCM02653.1 - 0.00029 20.7 1.6 1.3 8.7 0.0 3.2 3 0 0 3 3 3 2 AAA domain DUF2075 PF09848.9 CCM02653.1 - 0.0008 18.7 0.0 1.1 8.4 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CCM02653.1 - 0.0014 18.4 0.8 2.1 8.0 0.1 3.0 3 0 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.6 CCM02653.1 - 0.0021 18.2 0.0 3.8 7.6 0.0 2.9 2 0 0 2 2 2 0 Sigma-54 interaction domain UFD1 PF03152.14 CCM02653.1 - 0.0022 17.5 0.0 0.0042 16.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 NACHT PF05729.12 CCM02653.1 - 0.0022 17.9 0.2 1.2 9.1 0.0 3.0 3 0 0 3 3 3 1 NACHT domain Zeta_toxin PF06414.12 CCM02653.1 - 0.0027 17.0 0.0 1.6 7.9 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 CCM02653.1 - 0.0033 16.7 0.0 0.48 9.6 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Viral_helicase1 PF01443.18 CCM02653.1 - 0.007 16.1 0.0 0.81 9.4 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CCM02653.1 - 0.0075 16.6 2.3 4.6 7.6 0.0 3.7 4 1 0 5 5 2 0 AAA domain IPT PF01745.16 CCM02653.1 - 0.0089 15.4 0.1 2.4 7.5 0.0 2.3 2 0 0 2 2 2 1 Isopentenyl transferase T2SSE PF00437.20 CCM02653.1 - 0.031 13.4 0.0 1.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 CCM02653.1 - 0.043 13.5 0.2 8.4 6.1 0.0 2.9 3 0 0 3 3 2 0 Cytidylate kinase Zot PF05707.12 CCM02653.1 - 0.051 13.2 0.0 2 8.0 0.0 2.8 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) KAP_NTPase PF07693.14 CCM02653.1 - 0.071 12.3 0.2 0.89 8.7 0.0 2.6 2 2 2 4 4 4 0 KAP family P-loop domain Molydop_binding PF01568.21 CCM02653.1 - 0.084 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain NTPase_1 PF03266.15 CCM02653.1 - 0.094 12.6 0.5 15 5.5 0.0 3.3 3 0 0 3 3 3 0 NTPase Ribosomal_60s PF00428.19 CCM02653.1 - 7.6 7.2 11.2 5.3 7.7 5.5 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein DAGAT PF03982.13 CCM02654.1 - 2.1e-99 332.2 0.0 2.7e-99 331.8 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Cellulase PF00150.18 CCM02655.1 - 1.2e-13 51.2 0.4 2.8e-13 49.9 0.4 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) NAD_binding_10 PF13460.6 CCM02656.1 - 1.3e-09 38.2 0.1 1.8e-09 37.7 0.1 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCM02656.1 - 2.4e-05 23.9 0.0 3.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCM02656.1 - 2.7e-05 24.6 0.0 4.4e-05 23.9 0.0 1.5 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 CCM02656.1 - 0.011 14.9 0.0 0.59 9.3 0.0 2.3 1 1 0 2 2 2 0 Male sterility protein TORC_N PF12884.7 CCM02656.1 - 0.1 13.4 0.0 2.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus AAA_28 PF13521.6 CCM02656.1 - 0.14 12.4 0.1 0.27 11.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain 4HBT_2 PF13279.6 CCM02657.1 - 1.9e-12 47.7 0.0 3.1e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CCM02657.1 - 0.00047 20.4 0.0 0.00083 19.7 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 CCM02657.1 - 0.0047 16.2 0.0 0.0086 15.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-ACP thioesterase RuvA_C PF07499.13 CCM02657.1 - 0.053 14.0 0.0 0.14 12.6 0.0 1.7 2 0 0 2 2 2 0 RuvA, C-terminal domain AA_permease PF00324.21 CCM02658.1 - 2e-124 415.8 34.3 2.3e-124 415.6 34.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCM02658.1 - 5.6e-37 127.6 38.6 6.8e-37 127.3 38.6 1.1 1 0 0 1 1 1 1 Amino acid permease Ytp1 PF10355.9 CCM02659.1 - 3.8e-57 193.6 13.7 2.2e-55 187.9 13.7 2.2 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CCM02659.1 - 1.6e-25 88.9 1.0 1.6e-25 88.9 1.0 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF2427) HMG_box PF00505.19 CCM02660.1 - 8.6e-13 48.5 4.5 8.6e-13 48.5 4.5 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM02660.1 - 0.0084 16.7 2.5 0.01 16.4 1.9 1.5 1 1 0 1 1 1 1 HMG-box domain NOC3p PF07540.11 CCM02660.1 - 0.23 12.0 1.6 1.1 9.7 0.1 2.1 2 0 0 2 2 2 0 Nucleolar complex-associated protein UBX PF00789.20 CCM02662.1 - 1.6e-12 47.4 0.3 4.9e-12 45.9 0.0 1.9 2 0 0 2 2 2 1 UBX domain zf-C2H2_2 PF12756.7 CCM02662.1 - 0.012 15.9 0.9 0.032 14.6 0.3 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) UBA PF00627.31 CCM02662.1 - 0.015 15.2 0.0 0.043 13.7 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain OAM_alpha PF16552.5 CCM02662.1 - 0.046 13.6 1.0 9.2 6.2 0.0 2.4 2 0 0 2 2 2 0 D-ornithine 4,5-aminomutase alpha-subunit CpXC PF14353.6 CCM02662.1 - 1.9 8.6 8.0 1.5 8.9 5.4 2.0 1 1 1 2 2 2 0 CpXC protein RR_TM4-6 PF06459.12 CCM02662.1 - 8.3 6.1 20.0 12 5.6 20.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 CCM02662.1 - 8.4 4.8 19.1 11 4.4 19.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein V_ATPase_I PF01496.19 CCM02662.1 - 8.8 4.1 5.5 9.2 4.0 5.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Uds1 PF15456.6 CCM02663.1 - 0.2 11.8 18.6 0.027 14.6 5.0 3.1 2 1 1 3 3 3 0 Up-regulated During Septation THOC7 PF05615.13 CCM02663.1 - 7.5 6.8 12.9 72 3.7 12.9 2.4 1 1 0 1 1 1 0 Tho complex subunit 7 STT3 PF02516.14 CCM02664.1 - 4.8e-145 484.2 35.5 5.6e-143 477.4 35.5 2.3 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Phage_holin_5_2 PF16079.5 CCM02664.1 - 0.009 16.3 0.2 44 4.5 0.0 4.7 4 0 0 4 4 4 2 Phage holin family Hol44, in holin superfamily V Thioredoxin PF00085.20 CCM02666.1 - 9.8e-09 35.1 0.0 7.2e-08 32.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Ran_BP1 PF00638.18 CCM02667.1 - 2.7e-05 24.4 0.1 4.8e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 RanBP1 domain Dicty_REP PF05086.12 CCM02667.1 - 3.9 5.3 4.1 5.1 4.9 4.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RNase_H2_suC PF08615.11 CCM02669.1 - 4.8e-17 62.5 0.0 1e-16 61.4 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) MRC1 PF09444.10 CCM02670.1 - 4.2 7.9 21.9 1.2 9.6 2.1 3.6 3 0 0 3 3 3 0 MRC1-like domain ESCRT-II PF05871.12 CCM02671.1 - 1.2e-31 109.8 0.0 1.8e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit MFS_1 PF07690.16 CCM02672.1 - 7.3e-15 54.7 46.9 3.7e-09 36.0 23.2 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_Nu1 PF07471.12 CCM02673.1 - 0.13 12.1 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 NUDE_C PF04880.13 CCM02673.1 - 0.56 10.7 4.1 0.25 11.8 1.8 1.6 1 1 0 2 2 2 0 NUDE protein, C-terminal conserved region DUF3584 PF12128.8 CCM02675.1 - 0.00024 18.8 18.0 0.00024 18.8 18.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3584) DUF4047 PF13256.6 CCM02675.1 - 0.023 14.9 7.4 0.3 11.3 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Fez1 PF06818.15 CCM02675.1 - 0.029 14.8 33.5 0.85 10.0 16.0 3.1 2 1 1 3 3 3 0 Fez1 NPV_P10 PF05531.12 CCM02675.1 - 1.4 9.4 6.9 6.9 7.2 1.9 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein ISG65-75 PF11727.8 CCM02675.1 - 1.9 7.6 13.7 3.3 6.9 1.8 2.3 2 0 0 2 2 2 0 Invariant surface glycoprotein Fib_alpha PF08702.10 CCM02675.1 - 2 8.6 19.0 14 5.9 0.3 4.1 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Sec8_exocyst PF04048.14 CCM02675.1 - 2.3 8.1 18.4 1.5 8.7 1.8 3.9 3 1 1 4 4 4 0 Sec8 exocyst complex component specific domain DUF2730 PF10805.8 CCM02675.1 - 2.4 8.3 0.0 2.4 8.3 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2730) YabA PF06156.13 CCM02675.1 - 6.1 7.5 24.1 23 5.7 1.0 4.5 2 1 2 4 4 4 0 Initiation control protein YabA FAM184 PF15665.5 CCM02675.1 - 7.1 6.3 33.3 3.2 7.5 7.9 3.5 2 1 2 4 4 4 0 Family with sequence similarity 184, A and B ATG16 PF08614.11 CCM02675.1 - 7.3 6.8 41.6 12 6.1 0.0 4.9 2 1 3 5 5 5 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 CCM02675.1 - 7.7 6.6 17.4 2.7 8.1 0.4 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 CCM02675.1 - 8.3 5.8 33.0 0.29 10.5 11.0 3.0 2 1 1 3 3 3 0 Golgin subfamily A member 5 Atg14 PF10186.9 CCM02676.1 - 0.16 11.1 6.1 0.29 10.2 6.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IncFII_repA PF02387.15 CCM02676.1 - 0.3 10.3 5.5 0.46 9.7 5.5 1.2 1 0 0 1 1 1 0 IncFII RepA protein family TMPIT PF07851.13 CCM02676.1 - 0.68 9.1 5.9 1.1 8.4 5.9 1.4 1 0 0 1 1 1 0 TMPIT-like protein Ribosomal_S20p PF01649.18 CCM02676.1 - 0.83 10.3 6.3 7.3 7.3 6.4 2.5 1 1 0 1 1 1 0 Ribosomal protein S20 DivIC PF04977.15 CCM02676.1 - 1.1 9.0 12.4 3.8 7.3 2.6 3.3 2 1 1 3 3 3 0 Septum formation initiator Cep57_CLD_2 PF14197.6 CCM02676.1 - 5.2 7.2 11.2 14 5.9 4.0 3.4 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 UPF0242 PF06785.11 CCM02676.1 - 9.4 6.3 13.5 6.8 6.7 12.1 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus NMO PF03060.15 CCM02677.1 - 1.8e-51 175.5 0.7 2.7e-51 174.9 0.7 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCM02677.1 - 9.5e-06 24.8 1.5 0.00015 20.9 1.5 2.0 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CCM02677.1 - 0.011 14.7 3.7 0.017 14.1 3.7 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase PACT_coil_coil PF10495.9 CCM02679.1 - 7.3e-15 55.3 0.3 7.3e-15 55.3 0.3 4.2 4 0 0 4 4 4 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Laminin_II PF06009.12 CCM02679.1 - 0.0057 16.7 10.8 0.0057 16.7 10.8 9.6 5 3 6 11 11 11 4 Laminin Domain II DXPR_C PF13288.6 CCM02679.1 - 0.073 13.3 0.2 0.073 13.3 0.2 2.1 2 0 0 2 2 2 0 DXP reductoisomerase C-terminal domain Pox_A_type_inc PF04508.12 CCM02679.1 - 0.1 12.5 0.1 0.1 12.5 0.1 9.0 9 1 0 9 9 9 0 Viral A-type inclusion protein repeat PSCyt3 PF07627.11 CCM02679.1 - 5.3 7.4 5.9 2.1 8.7 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) CDP-OH_P_transf PF01066.21 CCM02680.1 - 4.5e-14 53.0 0.9 4.5e-14 53.0 0.9 2.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase p450 PF00067.22 CCM02682.1 - 2.4e-66 224.4 0.0 3e-66 224.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Matrilin_ccoil PF10393.9 CCM02682.1 - 0.12 12.2 1.4 0.96 9.4 0.0 2.7 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF1348 PF07080.11 CCM02683.1 - 2.9e-62 208.3 5.5 3.3e-62 208.2 5.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) DUF4440 PF14534.6 CCM02683.1 - 6.6e-05 23.3 0.1 0.00018 21.9 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 CCM02683.1 - 0.00021 21.9 0.5 0.00033 21.2 0.0 1.5 2 0 0 2 2 2 1 SnoaL-like domain zf-C2H2 PF00096.26 CCM02684.1 - 0.35 11.4 6.9 0.13 12.7 3.9 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM02684.1 - 1.8 9.6 5.0 4.8 8.3 5.0 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger p450 PF00067.22 CCM02686.1 - 3.7e-54 184.2 0.0 1e-49 169.5 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 T2SSF PF00482.23 CCM02686.1 - 0.027 14.4 1.0 0.43 10.5 2.0 2.4 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Tam41_Mmp37 PF09139.11 CCM02688.1 - 0.19 11.1 1.7 0.29 10.5 1.7 1.2 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DNA_topoisoIV PF00521.20 CCM02688.1 - 2.4 6.9 5.2 3.4 6.4 5.2 1.1 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A KfrA_N PF11740.8 CCM02688.1 - 5.3 7.8 13.4 0.59 10.8 8.0 2.1 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term MAD PF05557.13 CCM02688.1 - 5.3 5.3 14.3 1 7.6 8.7 2.4 2 1 0 2 2 2 0 Mitotic checkpoint protein p450 PF00067.22 CCM02690.1 - 6.3e-60 203.2 0.0 1.7e-59 201.8 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM02691.1 - 4.5e-61 207.0 0.0 1.7e-60 205.1 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF5435 PF17503.2 CCM02692.1 - 0.058 13.1 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5435) Phage_holin_2_1 PF04971.12 CCM02694.1 - 0.048 13.7 1.4 0.47 10.5 0.2 2.8 2 0 0 2 2 2 0 Bacteriophage P21 holin S HTH_3 PF01381.22 CCM02695.1 - 0.00014 21.8 0.0 0.00021 21.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CCM02695.1 - 0.00057 20.2 0.0 0.00059 20.1 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 CCM02695.1 - 0.017 14.7 0.1 0.033 13.9 0.1 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 GcrA PF07750.11 CCM02695.1 - 0.022 15.2 0.0 0.026 14.9 0.0 1.3 1 0 0 1 1 1 0 GcrA cell cycle regulator HTH_AsnC-type PF13404.6 CCM02695.1 - 0.028 14.3 0.0 0.093 12.6 0.0 1.9 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Sigma70_r4 PF04545.16 CCM02695.1 - 0.095 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_24 PF13412.6 CCM02695.1 - 0.11 12.1 0.1 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF1348 PF07080.11 CCM02696.1 - 3.2e-33 114.4 1.2 3.6e-33 114.3 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 CCM02696.1 - 5.1e-05 23.9 0.5 6.1e-05 23.6 0.5 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 CCM02696.1 - 0.0017 18.1 0.1 0.002 17.9 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase FMO-like PF00743.19 CCM02697.1 - 3e-21 75.4 0.3 4.9e-20 71.5 0.3 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCM02697.1 - 4.3e-16 59.0 0.0 1.3e-14 54.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM02697.1 - 1.5e-12 47.4 0.0 2.9e-09 36.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM02697.1 - 4.7e-10 39.1 0.1 3.9e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CCM02697.1 - 0.0008 19.9 0.0 0.09 13.3 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM02699.1 - 2.1e-26 92.9 0.0 4.8e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 CCM02699.1 - 1.4e-18 66.9 0.0 8.1e-18 64.4 0.0 2.0 2 0 0 2 2 2 1 Nitrite and sulphite reductase 4Fe-4S domain Fer2_BFD PF04324.15 CCM02699.1 - 6.3e-17 61.7 4.8 2.9e-13 50.0 4.0 2.7 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Pyr_redox PF00070.27 CCM02699.1 - 2.7e-13 50.3 0.0 8.7e-13 48.6 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR_ferr PF03460.17 CCM02699.1 - 1.7e-11 43.8 0.0 3.8e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rubredoxin_C PF18267.1 CCM02699.1 - 1.2e-06 28.3 0.3 0.022 14.7 0.1 2.9 3 0 0 3 3 3 2 Rubredoxin NAD+ reductase C-terminal domain Oxidored_molyb PF00174.19 CCM02700.1 - 6.2e-55 185.4 0.0 8.7e-55 185.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain MFS_1 PF07690.16 CCM02700.1 - 4.3e-24 85.1 22.3 5.7e-24 84.7 22.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4270 PF14092.6 CCM02700.1 - 0.019 14.1 0.0 0.028 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4270) RNR_Alpha PF17975.1 CCM02700.1 - 0.2 12.2 0.2 0.51 10.9 0.0 1.7 2 0 0 2 2 2 0 Ribonucleotide reductase alpha domain NAD_binding_1 PF00175.21 CCM02701.1 - 1.7e-28 99.4 0.0 3e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCM02701.1 - 1e-24 86.8 0.0 1.7e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 CCM02701.1 - 3e-15 56.1 0.0 6e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Mo-co_dimer PF03404.16 CCM02701.1 - 3.7e-12 46.5 0.5 6.2e-12 45.7 0.5 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain NAD_binding_6 PF08030.12 CCM02701.1 - 5.5e-05 23.3 0.0 0.0018 18.4 0.0 2.2 1 1 0 2 2 2 1 Ferric reductase NAD binding domain CAS_CSE1 PF03378.15 CCM02704.1 - 1.4e-119 399.5 1.1 2.4e-119 398.7 1.1 1.3 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 CCM02704.1 - 3e-98 329.1 0.0 4.5e-98 328.5 0.0 1.3 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 CCM02704.1 - 3.2e-18 65.4 0.1 1.5e-17 63.3 0.1 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 CCM02704.1 - 0.00019 21.8 3.1 1.1 9.7 0.1 4.0 4 0 0 4 4 4 2 HEAT repeats Xpo1 PF08389.12 CCM02704.1 - 0.087 12.9 0.5 1.1 9.4 0.0 2.9 3 0 0 3 3 3 0 Exportin 1-like protein HEAT PF02985.22 CCM02704.1 - 1.6 9.2 5.7 1.2e+02 3.4 0.1 4.5 3 0 0 3 3 3 0 HEAT repeat DUF4419 PF14388.6 CCM02705.1 - 6.1e-92 308.3 0.0 7.3e-92 308.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Gpr1_Fun34_YaaH PF01184.19 CCM02706.1 - 1.5e-77 259.9 16.0 1.7e-77 259.7 16.0 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Phage_holin_2_2 PF10746.9 CCM02706.1 - 0.74 9.5 3.4 10 5.9 0.2 2.7 2 1 1 3 3 3 0 Phage holin T7 family, holin superfamily II Acetyltransf_3 PF13302.7 CCM02707.1 - 5.2e-21 75.8 0.0 3e-20 73.3 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM02707.1 - 0.0004 20.3 0.0 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_8 PF13523.6 CCM02707.1 - 0.0025 17.5 4.3 0.021 14.5 0.0 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CCM02707.1 - 0.0074 16.4 0.0 0.019 15.1 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM02707.1 - 0.0084 16.3 0.0 0.11 12.8 0.0 2.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Aldedh PF00171.22 CCM02708.1 - 4.5e-182 605.7 0.1 5.1e-182 605.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pyr_redox_3 PF13738.6 CCM02709.1 - 3.6e-18 65.9 1.6 2.7e-10 40.0 0.3 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCM02709.1 - 1.5e-16 60.0 2.1 1.1e-14 53.8 0.0 2.4 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCM02709.1 - 2.9e-16 59.6 3.4 3.8e-11 42.8 1.7 3.1 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM02709.1 - 6.6e-11 41.9 1.1 5.7e-09 35.6 0.1 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CCM02709.1 - 2.6e-08 34.3 0.8 0.0076 16.8 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM02709.1 - 2.9e-07 30.6 0.5 3.2e-05 24.1 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCM02709.1 - 3.1e-05 23.4 3.6 0.0012 18.1 0.1 2.6 3 0 0 3 3 3 2 FAD binding domain 2-Hacid_dh_C PF02826.19 CCM02709.1 - 0.0017 17.7 0.0 0.48 9.8 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thi4 PF01946.17 CCM02709.1 - 0.0022 17.3 0.1 0.2 10.9 0.0 2.5 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 CCM02709.1 - 0.0037 16.9 6.1 0.22 11.1 0.4 3.6 3 1 1 4 4 4 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM02709.1 - 0.012 14.7 1.0 0.012 14.7 1.0 1.9 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 CCM02709.1 - 0.017 15.1 4.4 5.7 6.9 0.2 3.6 3 1 1 4 4 4 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CCM02709.1 - 0.029 13.7 0.5 4.4 6.5 0.0 3.0 2 1 1 3 3 3 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CCM02709.1 - 0.03 13.0 2.5 0.065 11.9 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 CCM02709.1 - 0.043 12.9 3.4 0.48 9.4 0.1 2.9 3 0 0 3 3 3 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CCM02709.1 - 0.048 12.7 0.5 0.15 11.1 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein XdhC_C PF13478.6 CCM02709.1 - 0.06 13.8 0.4 5.3 7.6 0.1 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain 3HCDH_N PF02737.18 CCM02709.1 - 0.11 12.4 1.0 1 9.2 0.1 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CCM02709.1 - 0.13 12.7 0.5 15 6.1 0.1 2.7 3 0 0 3 3 3 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 CCM02709.1 - 0.31 10.3 4.9 0.17 11.2 0.6 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase p450 PF00067.22 CCM02710.1 - 2.6e-15 56.2 0.1 2.9e-15 56.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCM02712.1 - 2.9e-39 134.6 0.3 3.5e-39 134.3 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM02712.1 - 8.6e-33 113.8 0.3 1.1e-32 113.5 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM02712.1 - 3.2e-12 46.7 0.4 4.3e-12 46.3 0.4 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CCM02712.1 - 0.022 14.1 0.1 0.061 12.6 0.0 1.6 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PA PF02225.22 CCM02712.1 - 0.035 14.1 1.3 1.5 8.9 0.3 2.5 1 1 1 2 2 2 0 PA domain Epimerase PF01370.21 CCM02712.1 - 0.044 13.3 0.7 0.14 11.6 0.7 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCM02712.1 - 0.064 12.4 0.0 0.09 11.9 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 CCM02712.1 - 0.088 12.6 0.3 0.2 11.5 0.3 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Phosducin PF02114.16 CCM02714.1 - 3.7e-14 52.3 0.0 1.3e-07 30.9 0.0 3.1 3 0 0 3 3 3 3 Phosducin p450 PF00067.22 CCM02715.1 - 4.5e-53 180.6 0.0 8.9e-53 179.7 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 PfkB PF00294.24 CCM02716.1 - 6e-12 45.5 0.0 0.00018 20.9 0.0 3.1 3 0 0 3 3 3 3 pfkB family carbohydrate kinase Acetyltransf_1 PF00583.25 CCM02717.1 - 1.9e-10 41.0 0.0 2.2e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCM02717.1 - 3.1e-06 27.5 0.0 4.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCM02717.1 - 3.1e-06 27.1 0.0 4.4e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain WD40 PF00400.32 CCM02720.1 - 2.5e-18 66.1 14.5 7.6e-05 23.4 0.3 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02720.1 - 0.00036 20.8 3.4 1.1 9.6 0.1 4.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM02720.1 - 0.042 12.8 0.5 2.4 7.0 0.0 3.0 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Sugar_tr PF00083.24 CCM02723.1 - 1e-121 407.0 20.0 1.5e-121 406.4 20.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM02723.1 - 4.8e-17 61.9 44.1 2e-13 50.0 15.9 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF2530 PF10745.9 CCM02723.1 - 0.082 13.2 3.2 0.1 12.9 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Inositol_P PF00459.25 CCM02724.1 - 5.6e-45 154.0 0.3 2.6e-39 135.4 0.1 2.1 2 0 0 2 2 2 2 Inositol monophosphatase family SAICAR_synt PF01259.18 CCM02726.1 - 0.23 11.1 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 SAICAR synthetase FHA PF00498.26 CCM02727.1 - 1.8e-08 34.6 0.0 4.5e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 FHA domain PIN_4 PF13638.6 CCM02728.1 - 1.6e-06 28.4 0.0 2.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 PIN domain Prefoldin PF02996.17 CCM02729.1 - 1.1e-28 99.6 1.7 1.3e-28 99.3 1.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 CCM02729.1 - 2.6e-05 24.1 3.0 0.0015 18.4 0.5 2.1 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.6 CCM02729.1 - 0.00034 20.6 0.2 0.00063 19.8 0.2 1.5 1 1 0 1 1 1 1 Prefoldin subunit FlaC_arch PF05377.11 CCM02729.1 - 0.00081 19.7 1.1 0.24 11.8 0.0 2.3 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) Med9 PF07544.13 CCM02729.1 - 0.0025 17.9 2.1 0.69 10.0 0.2 2.2 2 0 0 2 2 2 2 RNA polymerase II transcription mediator complex subunit 9 BLOC1_2 PF10046.9 CCM02729.1 - 0.012 15.9 2.1 3.5 8.0 0.4 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Dad2 PF08654.10 CCM02729.1 - 0.015 15.7 2.7 3.7 8.0 0.7 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad2 Seryl_tRNA_N PF02403.22 CCM02729.1 - 0.016 15.4 1.4 2.4 8.5 0.2 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.9 CCM02729.1 - 0.018 15.0 1.5 1 9.4 0.1 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COG2 PF06148.11 CCM02729.1 - 0.024 14.7 1.3 0.72 9.9 0.2 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cep57_MT_bd PF06657.13 CCM02729.1 - 0.037 14.5 1.4 0.19 12.2 0.1 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4201 PF13870.6 CCM02729.1 - 0.043 13.5 6.3 0.72 9.6 2.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) CLZ PF16526.5 CCM02729.1 - 0.051 13.9 3.4 5.1 7.5 0.6 2.6 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4140 PF13600.6 CCM02729.1 - 0.057 13.9 0.9 14 6.2 0.6 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.10 CCM02729.1 - 0.068 13.4 5.9 2.1 8.5 5.9 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family XkdW PF09636.10 CCM02729.1 - 0.09 12.9 0.5 1.3 9.1 0.1 2.1 2 0 0 2 2 2 0 XkdW protein DUF1664 PF07889.12 CCM02729.1 - 0.091 12.8 3.5 6.1 6.9 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 CCM02729.1 - 0.13 12.7 6.4 0.29 11.7 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 Spc24 PF08286.11 CCM02729.1 - 0.18 12.1 3.5 4 7.7 0.0 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Snapin_Pallidin PF14712.6 CCM02729.1 - 0.28 11.6 6.4 3.2 8.2 0.4 2.5 2 1 0 2 2 2 0 Snapin/Pallidin Utp12 PF04003.12 CCM02729.1 - 0.28 11.5 2.7 6.5 7.1 0.2 2.5 2 1 1 3 3 3 0 Dip2/Utp12 Family UPF0242 PF06785.11 CCM02729.1 - 0.32 11.1 4.9 1.8 8.6 0.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus IL6 PF00489.17 CCM02729.1 - 0.4 10.2 4.0 0.75 9.3 1.5 2.0 1 1 1 2 2 2 0 Interleukin-6/G-CSF/MGF family DUF2347 PF09804.9 CCM02730.1 - 9.7e-42 143.5 0.0 2.5e-41 142.1 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 CCM02730.1 - 0.00075 18.3 0.1 7.6 5.1 0.2 3.2 3 0 0 3 3 3 3 Transport protein Avl9 DUF4484 PF14831.6 CCM02730.1 - 0.011 15.8 0.1 1.2 9.2 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4484) SPA PF08616.10 CCM02730.1 - 0.028 14.4 0.0 0.099 12.6 0.0 1.9 1 1 0 1 1 1 0 Stabilization of polarity axis SAC3_GANP PF03399.16 CCM02731.1 - 3.2e-66 223.7 0.9 5.6e-66 222.9 0.9 1.3 1 0 0 1 1 1 1 SAC3/GANP family Fer4_17 PF13534.6 CCM02731.1 - 0.066 13.8 0.4 0.24 12.0 0.1 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Pkinase PF00069.25 CCM02732.1 - 1.9e-75 253.6 0.0 2.6e-75 253.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain ATP_bind_1 PF03029.17 CCM02732.1 - 2.4e-67 227.2 0.0 3.9e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Pkinase_Tyr PF07714.17 CCM02732.1 - 9.1e-33 113.6 0.0 1.3e-32 113.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FeoB_N PF02421.18 CCM02732.1 - 0.00054 19.5 1.2 0.12 11.8 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B Haspin_kinase PF12330.8 CCM02732.1 - 0.00055 19.0 0.2 0.0046 16.0 0.2 2.0 1 1 0 1 1 1 1 Haspin like kinase domain MMR_HSR1 PF01926.23 CCM02732.1 - 0.0014 18.7 0.0 0.0076 16.3 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 CCM02732.1 - 0.008 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCM02732.1 - 0.012 15.7 0.0 0.031 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CCM02732.1 - 0.025 14.2 0.0 2.9 7.5 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain APH PF01636.23 CCM02732.1 - 0.028 14.4 1.8 0.12 12.3 0.1 2.3 2 1 1 3 3 2 0 Phosphotransferase enzyme family RsgA_GTPase PF03193.16 CCM02732.1 - 0.037 13.9 0.0 3.7 7.4 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase NB-ARC PF00931.22 CCM02732.1 - 0.058 12.6 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Seadorna_VP7 PF07387.11 CCM02732.1 - 0.064 12.3 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 CCM02732.1 - 0.079 12.3 0.1 2.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Kinase-like NACHT PF05729.12 CCM02732.1 - 0.18 11.7 0.0 0.52 10.2 0.0 1.7 2 0 0 2 2 2 0 NACHT domain WSC PF01822.19 CCM02733.1 - 1.4e-70 233.5 59.2 3.7e-19 68.7 10.3 4.3 4 0 0 4 4 4 4 WSC domain Glyoxal_oxid_N PF07250.11 CCM02733.1 - 2.8e-26 92.2 0.0 3.9e-25 88.4 0.0 2.4 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 CCM02733.1 - 1.3e-21 76.7 0.1 3.1e-21 75.5 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Gti1_Pac2 PF09729.9 CCM02736.1 - 8e-58 195.5 0.0 1.4e-57 194.7 0.0 1.4 1 0 0 1 1 1 1 Gti1/Pac2 family Aldo_ket_red PF00248.21 CCM02737.1 - 1.3e-72 244.5 0.0 1.5e-72 244.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MMR_HSR1 PF01926.23 CCM02738.1 - 1.5e-18 66.9 0.1 4.6e-15 55.7 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM02738.1 - 2.2e-08 34.2 0.0 5.2e-07 29.7 0.0 3.0 3 1 0 3 3 3 1 RsgA GTPase FeoB_N PF02421.18 CCM02738.1 - 1.1e-07 31.5 0.1 6.3e-06 25.8 0.0 2.8 3 0 0 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CCM02738.1 - 0.00013 22.1 0.0 0.023 14.8 0.0 2.3 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 CCM02738.1 - 0.00043 20.7 0.5 0.05 14.0 0.1 2.9 2 2 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 CCM02738.1 - 0.00085 18.9 0.0 0.039 13.5 0.0 2.6 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 CCM02738.1 - 0.00096 18.2 0.1 0.0021 17.1 0.1 1.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 CCM02738.1 - 0.011 16.0 0.0 3.8 7.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 CCM02738.1 - 0.043 14.4 0.3 0.19 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CCM02738.1 - 0.071 12.7 0.1 2.2 7.8 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 CCM02738.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Septin FMO-like PF00743.19 CCM02739.1 - 3.1e-15 55.6 0.1 3.8e-14 52.0 0.0 2.2 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCM02739.1 - 4.3e-12 46.1 0.0 1.3e-11 44.5 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CCM02739.1 - 2.1e-11 43.6 0.4 2.7e-09 36.6 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCM02739.1 - 3.5e-09 36.3 0.0 3.7e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM02739.1 - 1.4e-06 27.8 0.3 0.0018 17.6 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM02739.1 - 0.00014 21.6 2.8 0.00068 19.3 1.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCM02739.1 - 0.00098 19.1 0.1 0.52 10.3 0.0 3.3 3 1 0 3 3 3 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 CCM02739.1 - 0.015 15.3 0.0 0.51 10.4 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 CCM02739.1 - 0.1 13.1 1.3 0.5 11.0 0.3 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCM02739.1 - 0.28 10.2 2.0 6.4 5.7 0.6 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A Thi4 PF01946.17 CCM02739.1 - 0.32 10.2 0.7 0.68 9.1 0.1 1.8 2 0 0 2 2 2 0 Thi4 family Glyco_transf_49 PF13896.6 CCM02740.1 - 0.006 16.0 0.3 0.045 13.1 0.6 2.0 1 1 1 2 2 2 1 Glycosyl-transferase for dystroglycan MmgE_PrpD PF03972.14 CCM02741.1 - 2.4e-153 510.8 0.0 2.9e-153 510.5 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family MoaF PF10703.9 CCM02741.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 MoaF N-terminal domain GTP_EFTU PF00009.27 CCM02742.1 - 3.8e-49 166.9 0.1 1.9e-48 164.6 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CCM02742.1 - 2.5e-34 117.6 0.0 8e-34 116.0 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 CCM02742.1 - 2.5e-30 104.4 0.0 4.9e-30 103.4 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CCM02742.1 - 1.2e-22 79.7 0.1 3.1e-22 78.4 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCM02742.1 - 3.5e-12 46.5 0.0 8.6e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CCM02742.1 - 1.8e-06 27.8 0.0 4.6e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain SBDS_C PF09377.10 CCM02742.1 - 0.12 12.4 0.0 0.52 10.3 0.0 2.2 2 1 0 2 2 2 0 SBDS protein C-terminal domain SFTA2 PF15210.6 CCM02742.1 - 0.18 11.7 0.0 0.57 10.2 0.0 1.8 2 0 0 2 2 2 0 Surfactant-associated protein 2 Pectinesterase PF01095.19 CCM02743.1 - 7e-23 80.8 0.0 2.2e-22 79.1 0.0 1.7 1 1 0 1 1 1 1 Pectinesterase CBM_21 PF03370.13 CCM02744.1 - 3.3e-23 82.0 0.0 5.2e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 CCM02744.1 - 1.3e-07 32.1 0.0 2.6e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) TPMT PF05724.11 CCM02748.1 - 7.1e-37 127.2 0.0 9.5e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 CCM02748.1 - 2.6e-12 47.3 0.0 3.6e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM02748.1 - 7.3e-11 42.1 0.0 1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM02748.1 - 5.4e-09 36.6 0.0 7.8e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM02748.1 - 4.6e-08 33.7 0.0 7.2e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM02748.1 - 1e-07 32.0 0.0 1.2e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 CCM02748.1 - 0.00042 19.8 0.0 0.00055 19.4 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB CMAS PF02353.20 CCM02748.1 - 0.0045 16.3 0.0 0.0092 15.3 0.0 1.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 CCM02748.1 - 0.14 12.1 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CCM02748.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AP3D1 PF06375.11 CCM02751.1 - 5.4 7.2 9.1 2.5 8.3 3.6 2.3 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DAP PF15228.6 CCM02752.1 - 0.51 11.5 6.6 0.77 11.0 0.2 2.4 1 1 1 2 2 2 0 Death-associated protein Ribosomal_L28e PF01778.17 CCM02753.1 - 1.6e-13 51.4 0.0 8.6e-07 29.7 0.0 2.3 1 1 1 2 2 2 2 Ribosomal L28e protein family O-FucT PF10250.9 CCM02754.1 - 3.2e-11 43.5 0.0 4.5e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase COX7a PF02238.15 CCM02754.1 - 0.32 11.4 0.2 0.32 11.4 0.2 1.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII O-FucT PF10250.9 CCM02755.1 - 5.9e-07 29.5 0.0 9e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Homeodomain PF00046.29 CCM02755.1 - 0.00075 19.3 1.3 0.0084 15.9 1.3 2.3 1 1 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 CCM02756.1 - 0.00053 19.8 0.9 0.0032 17.3 0.3 2.4 1 1 1 2 2 2 2 Homeodomain Homeobox_KN PF05920.11 CCM02756.1 - 0.0073 16.2 0.5 0.068 13.1 0.1 2.4 2 0 0 2 2 2 1 Homeobox KN domain Ribosomal_S15 PF00312.22 CCM02757.1 - 3.3e-26 91.3 1.3 5.8e-26 90.5 1.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 RhoGEF PF00621.20 CCM02758.1 - 2.1e-35 122.6 0.0 3.2e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 CCM02758.1 - 7e-06 26.5 0.0 2e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 PH domain NAGLU PF05089.12 CCM02759.1 - 7.6e-133 442.6 8.5 1.1e-132 442.0 8.5 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 CCM02759.1 - 3.8e-72 243.0 1.4 5.5e-72 242.5 1.4 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 CCM02759.1 - 4.3e-11 42.4 0.0 1.1e-10 41.2 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain NGP1NT PF08153.12 CCM02760.1 - 6.9e-51 171.8 0.0 1.6e-50 170.6 0.0 1.6 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CCM02760.1 - 1.5e-17 63.7 0.1 5.9e-14 52.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CCM02760.1 - 3.1e-06 26.8 0.5 3.8e-05 23.3 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCM02760.1 - 1.8e-05 24.7 0.0 4.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Arf PF00025.21 CCM02760.1 - 0.00025 20.5 0.1 0.17 11.3 0.0 3.1 3 0 0 3 3 3 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM02760.1 - 0.00093 18.8 0.2 0.051 13.1 0.1 2.7 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Roc PF08477.13 CCM02760.1 - 0.12 12.6 0.1 23 5.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CCM02760.1 - 0.47 10.5 5.5 6.2 6.9 0.2 3.6 3 1 1 4 4 4 0 Dynamin family Enolase_C PF00113.22 CCM02761.1 - 9.4e-145 481.4 0.0 1.3e-144 480.9 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CCM02761.1 - 6.3e-57 191.4 0.1 1.1e-56 190.6 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CCM02761.1 - 7.2e-09 35.5 0.0 1.1e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CCM02761.1 - 0.00057 19.1 0.8 0.0012 18.1 0.1 1.8 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus Glyco_hydro_47 PF01532.20 CCM02763.1 - 3.5e-145 484.4 0.0 4.1e-145 484.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 APH PF01636.23 CCM02764.1 - 8.4e-07 29.2 0.0 2.4e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 CCM02764.1 - 9.1e-06 24.8 0.0 0.027 13.3 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) zf-C2H2 PF00096.26 CCM02765.1 - 2.2e-07 31.0 15.0 8.6e-05 22.8 2.5 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM02765.1 - 0.0012 19.5 11.0 0.06 14.2 2.1 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CCM02765.1 - 0.011 16.0 2.2 0.057 13.7 2.6 1.9 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 CCM02765.1 - 0.58 10.5 3.2 2.5 8.5 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 CCM02765.1 - 5 7.1 5.8 20 5.2 0.2 3.0 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Ogr_Delta PF04606.12 CCM02765.1 - 6.8 6.8 7.3 4.4 7.4 0.1 2.9 2 1 1 3 3 3 0 Ogr/Delta-like zinc finger zf-C2H2 PF00096.26 CCM02767.1 - 3.3e-08 33.6 14.5 0.00034 20.9 2.8 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM02767.1 - 2.6e-07 30.8 3.8 2.6e-07 30.8 3.8 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCM02767.1 - 5.4e-05 23.7 13.4 0.0035 18.1 2.4 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCM02767.1 - 0.00032 20.6 1.0 0.00032 20.6 1.0 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 CCM02767.1 - 0.0033 17.7 8.1 0.0063 16.8 8.1 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 CCM02767.1 - 0.051 13.4 0.2 0.099 12.5 0.2 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-H2C2_5 PF13909.6 CCM02767.1 - 0.086 12.6 7.1 0.99 9.2 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 CCM02767.1 - 0.1 12.9 3.4 0.12 12.7 0.1 2.3 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_9 PF16293.5 CCM02767.1 - 0.15 12.0 0.3 0.33 10.8 0.3 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zf-C2H2_11 PF16622.5 CCM02767.1 - 0.54 10.1 8.6 0.96 9.3 3.5 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 CCM02767.1 - 1.2 9.2 5.9 15 5.7 0.4 2.3 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_2 PF12756.7 CCM02767.1 - 1.7 9.1 5.7 4.3 7.7 5.7 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 CCM02767.1 - 1.9 9.0 4.2 0.76 10.2 0.8 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type EF-hand_7 PF13499.6 CCM02768.1 - 5.5e-25 87.6 14.6 1.6e-13 50.9 4.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CCM02768.1 - 1.8e-24 83.4 18.7 2.4e-09 36.1 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CCM02768.1 - 1.7e-20 71.1 13.7 2e-08 33.5 0.1 4.6 4 1 1 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 CCM02768.1 - 1.7e-15 56.6 12.5 6.4e-09 35.5 1.7 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 CCM02768.1 - 2e-11 42.8 7.2 0.0011 18.3 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 CCM02768.1 - 2.3e-11 43.9 2.5 3.9e-05 23.9 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CCM02768.1 - 8.9e-08 32.0 8.7 0.00084 19.3 0.1 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 CCM02768.1 - 0.00065 19.7 2.3 0.059 13.3 0.0 3.1 2 1 2 4 4 4 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 CCM02768.1 - 0.0059 16.9 3.5 0.49 10.7 0.2 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 CCM02768.1 - 0.014 15.7 2.4 0.24 11.8 0.4 2.5 2 1 0 2 2 2 0 EF-hand domain SurA_N_2 PF13623.6 CCM02768.1 - 0.067 13.1 1.4 3.6 7.5 0.3 2.5 1 1 0 2 2 2 0 SurA N-terminal domain Com_YlbF PF06133.11 CCM02768.1 - 0.36 11.5 3.6 16 6.1 0.4 2.7 2 1 1 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA TauD PF02668.16 CCM02769.1 - 7.7e-35 121.0 0.2 5.3e-31 108.4 0.0 2.9 2 1 1 3 3 3 2 Taurine catabolism dioxygenase TauD, TfdA family TauD PF02668.16 CCM02770.1 - 9.8e-41 140.3 0.1 1.4e-40 139.8 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NACHT PF05729.12 CCM02771.1 - 0.075 12.9 0.1 8.6 6.2 0.0 2.3 2 0 0 2 2 2 0 NACHT domain GalKase_gal_bdg PF10509.9 CCM02772.1 - 2.3e-20 71.9 0.1 4.2e-20 71.0 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 CCM02772.1 - 4.2e-14 52.5 1.9 1.1e-13 51.2 1.9 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCM02772.1 - 5.7e-14 52.2 0.0 1.1e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal MFS_1 PF07690.16 CCM02774.1 - 4.9e-29 101.4 22.8 6.1e-29 101.1 20.4 2.0 1 1 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CCM02774.1 - 0.0038 16.6 0.8 0.0038 16.6 0.8 2.2 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB EOS1 PF12326.8 CCM02774.1 - 3.9 7.4 9.1 6.4 6.7 4.5 2.9 2 1 0 2 2 2 0 N-glycosylation protein DIOX_N PF14226.6 CCM02775.1 - 4.3e-18 66.2 0.0 1.1e-17 64.9 0.0 1.7 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM02775.1 - 1.5e-12 47.9 0.0 3e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF5127 PF17168.4 CCM02776.1 - 1.4e-75 254.0 2.3 2.4e-75 253.2 2.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CCM02776.1 - 4.9e-54 182.6 0.4 1.1e-53 181.4 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 CCM02776.1 - 2.6e-32 112.6 2.2 5.1e-32 111.6 2.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 CCM02776.1 - 3.7e-06 26.4 0.2 9.4e-06 25.1 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) SKG6 PF08693.10 CCM02776.1 - 0.0051 16.2 1.9 0.0051 16.2 1.9 2.0 2 0 0 2 2 2 1 Transmembrane alpha-helix domain RTBV_P12 PF06361.11 CCM02776.1 - 0.08 13.3 0.2 0.08 13.3 0.2 2.1 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein XPC-binding PF09280.11 CCM02776.1 - 0.2 11.4 0.5 0.41 10.4 0.5 1.4 1 0 0 1 1 1 0 XPC-binding domain TFIIF_beta PF02270.15 CCM02777.1 - 8e-27 93.2 0.3 1.3e-26 92.5 0.3 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 CCM02777.1 - 1e-17 65.1 0.0 1.1e-15 58.6 0.0 2.5 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus Tau95 PF09734.9 CCM02777.1 - 0.0045 17.8 0.0 0.0077 17.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain NOA36 PF06524.12 CCM02777.1 - 6.6 6.0 6.5 13 5.0 6.5 1.5 1 0 0 1 1 1 0 NOA36 protein PPI_Ypi1 PF07491.11 CCM02778.1 - 9e-24 83.1 2.3 2.2e-23 81.8 2.3 1.7 1 0 0 1 1 1 1 Protein phosphatase inhibitor SWIRM-assoc_2 PF16496.5 CCM02778.1 - 0.15 10.9 1.0 0.2 10.5 1.0 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal zf-MYND PF01753.18 CCM02779.1 - 5.5e-11 42.4 10.3 1.2e-10 41.3 10.3 1.6 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 CCM02779.1 - 0.018 15.3 6.1 0.032 14.5 6.1 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf_C2H2_13 PF18508.1 CCM02779.1 - 0.56 9.8 3.6 0.87 9.2 0.4 2.5 1 1 1 2 2 2 0 Zinc finger domain IDO PF01231.18 CCM02780.1 - 3.4e-131 438.0 0.0 6.5e-130 433.8 0.0 2.0 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF4965 PF16335.5 CCM02781.1 - 4.6e-56 189.2 0.2 9.5e-56 188.2 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 CCM02781.1 - 5.4e-42 144.1 5.5 1e-41 143.1 5.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF5127 PF17168.4 CCM02781.1 - 2.3e-32 112.6 9.6 3.6e-29 102.2 0.4 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF5127) SKG6 PF08693.10 CCM02781.1 - 0.013 14.9 3.5 0.024 14.0 3.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CAMSAP_CC1 PF17095.5 CCM02781.1 - 0.38 10.6 1.0 0.57 10.1 0.2 1.7 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin DUF2613 PF11021.8 CCM02781.1 - 0.4 10.8 3.1 0.65 10.2 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) DUF3713 PF12506.8 CCM02781.1 - 0.64 10.3 2.6 11 6.3 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) ThrE PF06738.12 CCM02782.1 - 5e-25 88.3 0.1 6.7e-25 87.9 0.1 1.1 1 0 0 1 1 1 1 Putative threonine/serine exporter Acetyltransf_1 PF00583.25 CCM02783.1 - 9.9e-10 38.7 0.0 1.4e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM02783.1 - 7.4e-07 29.1 0.1 1.4e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM02783.1 - 7.8e-07 29.4 0.1 1.5e-06 28.5 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM02783.1 - 4.6e-05 23.3 0.0 7.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CCM02783.1 - 0.00016 21.8 0.0 0.00024 21.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCM02783.1 - 0.0083 16.2 0.1 0.016 15.3 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain ADH_zinc_N PF00107.26 CCM02785.1 - 6.3e-15 55.3 0.0 1.1e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM02785.1 - 6.7e-08 32.4 0.0 1.2e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCM02785.1 - 0.029 15.4 0.0 0.046 14.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CCM02785.1 - 0.072 13.0 0.0 0.19 11.6 0.0 1.7 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase FAD_binding_4 PF01565.23 CCM02786.1 - 2.4e-06 27.3 0.0 0.047 13.4 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain ALO PF04030.14 CCM02786.1 - 2e-05 24.6 2.3 5.6e-05 23.1 2.3 1.8 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase Septin PF00735.18 CCM02789.1 - 4.8e-109 364.0 0.0 6.8e-109 363.5 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCM02789.1 - 1.6e-07 31.4 0.0 4.2e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM02789.1 - 0.0031 17.4 0.8 0.035 14.0 0.6 2.6 2 1 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CCM02789.1 - 0.0048 16.2 0.0 0.0085 15.4 0.0 1.4 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 CCM02789.1 - 0.0054 16.3 0.1 0.1 12.1 0.0 2.3 2 1 0 3 3 3 1 Elongation factor Tu GTP binding domain IIGP PF05049.13 CCM02789.1 - 0.015 14.4 0.1 0.03 13.4 0.1 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.23 CCM02789.1 - 0.019 15.0 3.7 1.2 9.1 0.0 2.7 2 1 1 3 3 3 0 Dynamin family FtsK_SpoIIIE PF01580.18 CCM02789.1 - 0.048 13.0 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Roc PF08477.13 CCM02789.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MutS_III PF05192.18 CCM02790.1 - 9.7e-31 107.5 0.1 2e-30 106.5 0.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 CCM02790.1 - 4.3e-22 78.5 0.0 8.1e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CCM02790.1 - 4.8e-10 39.8 0.0 1.4e-09 38.3 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_V PF00488.21 CCM02791.1 - 1.8e-70 236.9 0.0 2.2e-70 236.5 0.0 1.1 1 0 0 1 1 1 1 MutS domain V AAA_27 PF13514.6 CCM02791.1 - 8.7e-05 22.2 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCM02791.1 - 0.003 17.2 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CCM02791.1 - 0.0068 16.9 0.0 0.0096 16.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CCM02791.1 - 0.067 13.2 0.0 0.15 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain Aconitase PF00330.20 CCM02792.1 - 2.9e-142 474.9 0.0 4.5e-142 474.3 0.0 1.3 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCM02792.1 - 1.8e-34 118.9 0.0 2.9e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 CCM02792.1 - 0.2 10.3 0.1 1.9 7.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF521) Oxysterol_BP PF01237.18 CCM02794.1 - 8e-117 390.2 0.1 1.8e-116 389.1 0.1 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 CCM02794.1 - 1.1e-09 38.5 0.2 3.9e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Ras PF00071.22 CCM02795.1 - 1.3e-52 177.7 0.1 1.6e-52 177.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM02795.1 - 1.7e-29 102.5 0.0 2.8e-29 101.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM02795.1 - 8.4e-12 44.9 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCM02795.1 - 9e-07 29.0 0.0 1.8e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCM02795.1 - 9.7e-06 25.2 0.0 0.00028 20.5 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM02795.1 - 9.9e-05 22.3 0.1 0.0066 16.4 0.0 2.3 2 1 0 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 CCM02795.1 - 0.00055 19.8 0.2 0.02 14.7 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 CCM02795.1 - 0.00076 18.9 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 CCM02795.1 - 0.00077 19.2 0.0 0.18 11.6 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 CCM02795.1 - 0.0014 18.2 0.0 0.0042 16.7 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 CCM02795.1 - 0.0056 16.0 0.2 0.1 11.8 0.0 2.2 2 1 0 2 2 2 1 Septin AAA_22 PF13401.6 CCM02795.1 - 0.015 15.6 0.0 0.04 14.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCM02795.1 - 0.015 15.7 0.1 0.026 14.9 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CCM02795.1 - 0.025 14.1 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 CCM02795.1 - 0.029 14.1 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCM02795.1 - 0.05 13.6 0.0 0.15 12.1 0.0 1.7 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCM02795.1 - 0.058 13.9 0.0 1.8 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CCM02795.1 - 0.082 12.8 0.8 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Glyco_hydro_75 PF07335.11 CCM02795.1 - 0.086 13.1 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 NACHT PF05729.12 CCM02795.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ATG16 PF08614.11 CCM02796.1 - 7e-42 143.9 13.0 7e-42 143.9 13.0 1.9 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Fez1 PF06818.15 CCM02796.1 - 0.018 15.5 21.2 0.036 14.5 16.9 2.0 1 1 1 2 2 2 0 Fez1 PPR_2 PF13041.6 CCM02796.1 - 0.033 14.4 0.2 0.069 13.4 0.2 1.4 1 0 0 1 1 1 0 PPR repeat family Spc7 PF08317.11 CCM02796.1 - 0.084 11.7 22.1 0.029 13.2 17.3 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein FlaC_arch PF05377.11 CCM02796.1 - 0.27 11.7 10.3 6.9 7.1 1.0 3.6 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF5320 PF17253.2 CCM02796.1 - 0.35 12.0 2.9 11 7.1 2.2 2.8 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DUF2408 PF10303.9 CCM02796.1 - 0.54 10.8 11.7 2.3 8.8 11.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) zf-C4H2 PF10146.9 CCM02796.1 - 1.1 9.5 14.5 2.8 8.2 14.5 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein DUF16 PF01519.16 CCM02796.1 - 1.4 9.4 12.3 0.47 11.0 7.0 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 YabA PF06156.13 CCM02796.1 - 1.9 9.2 18.4 3.3 8.4 9.4 2.9 1 1 1 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 CCM02796.1 - 1.9 8.7 15.5 1.8 8.7 7.5 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ALMT PF11744.8 CCM02796.1 - 6 5.6 13.9 7.1 5.3 13.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter USP8_interact PF08941.10 CCM02796.1 - 8.1 6.2 9.0 1.2 8.9 3.4 2.1 1 1 2 3 3 3 0 USP8 interacting DUF4407 PF14362.6 CCM02796.1 - 8.7 5.6 16.0 20 4.4 16.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) RRM_1 PF00076.22 CCM02800.1 - 1.9e-54 181.4 0.0 9e-19 67.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCM02800.1 - 1.2e-08 34.6 0.0 5.5e-05 22.8 0.0 3.1 2 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCM02800.1 - 7.2e-07 29.0 0.0 0.00028 20.7 0.0 3.0 3 0 0 3 3 3 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CCM02800.1 - 0.0024 17.8 0.1 1.8 8.6 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 CCM02800.1 - 0.0085 16.1 0.0 4.1 7.5 0.0 2.6 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_7 PF16367.5 CCM02800.1 - 0.014 15.5 0.0 0.35 11.0 0.0 2.9 3 1 0 3 3 3 0 RNA recognition motif PHM7_cyt PF14703.6 CCM02800.1 - 0.14 12.4 0.0 22 5.2 0.0 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter NupH_GANP PF16768.5 CCM02800.1 - 0.5 10.0 6.0 0.79 9.4 6.0 1.2 1 0 0 1 1 1 0 Nucleoporin homology of Germinal-centre associated nuclear protein Band_7 PF01145.25 CCM02801.1 - 2e-24 86.5 0.2 3.7e-24 85.7 0.2 1.5 1 0 0 1 1 1 1 SPFH domain / Band 7 family Asn_synthase PF00733.21 CCM02801.1 - 7.4e-19 68.6 0.9 1.8e-08 34.5 0.1 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 CCM02801.1 - 4.1e-08 33.2 0.0 2.8e-07 30.5 0.0 2.4 2 1 0 2 2 2 1 Glutamine amidotransferase domain QueC PF06508.13 CCM02801.1 - 0.18 11.2 0.0 0.56 9.7 0.0 1.8 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC 6PGD PF00393.19 CCM02802.1 - 6.3e-125 416.3 0.0 7.7e-125 416.1 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CCM02802.1 - 2.5e-49 167.5 0.0 3.7e-49 166.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CCM02802.1 - 0.014 15.9 0.0 0.033 14.8 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 CCM02802.1 - 0.071 12.8 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 CCM02802.1 - 0.096 12.0 0.1 0.28 10.5 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CCM02802.1 - 0.14 12.0 0.3 0.49 10.3 0.1 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CoatB PF10389.9 CCM02802.1 - 0.8 9.6 3.3 6.2 6.7 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage coat protein B Aminotran_4 PF01063.19 CCM02803.1 - 4.7e-22 79.0 0.0 6.4e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Trypsin_2 PF13365.6 CCM02804.1 - 2.6e-07 31.6 0.0 4.9e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain SKG6 PF08693.10 CCM02805.1 - 6.5e-06 25.5 4.5 1.1e-05 24.7 4.5 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 CCM02805.1 - 0.00021 21.0 0.9 0.00037 20.2 0.9 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 YGGT PF02325.17 CCM02805.1 - 0.017 15.5 0.0 0.036 14.5 0.0 1.5 1 0 0 1 1 1 0 YGGT family Amnionless PF14828.6 CCM02805.1 - 0.03 13.2 0.0 0.041 12.7 0.0 1.1 1 0 0 1 1 1 0 Amnionless EphA2_TM PF14575.6 CCM02805.1 - 0.04 14.8 0.0 0.078 13.9 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CBM_6 PF03422.15 CCM02805.1 - 0.16 12.3 0.5 12 6.2 0.1 2.5 1 1 1 2 2 2 0 Carbohydrate binding module (family 6) DUF2207 PF09972.9 CCM02805.1 - 0.23 10.2 3.0 0.39 9.4 2.8 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Gemini_mov PF01708.16 CCM02805.1 - 1 9.1 0.0 1 9.1 0.0 2.5 2 0 0 2 2 2 0 Geminivirus putative movement protein ORC6 PF05460.13 CCM02805.1 - 4.6 6.4 12.0 5.2 6.2 11.1 1.4 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) TMEM208_SND2 PF05620.11 CCM02806.1 - 2.5e-54 183.6 0.0 2.8e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Myb_DNA-binding PF00249.31 CCM02807.1 - 2.9e-50 168.2 3.8 8.8e-16 57.8 0.1 5.5 5 0 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCM02807.1 - 5.5e-39 132.2 0.1 3.2e-10 40.1 0.0 5.6 3 2 3 6 6 6 4 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 CCM02807.1 - 4.3e-06 27.0 5.9 0.59 10.5 0.0 5.5 5 1 0 5 5 5 2 Myb/SANT-like DNA-binding domain SLIDE PF09111.10 CCM02807.1 - 0.00014 21.9 0.1 0.2 11.7 0.0 2.7 2 0 0 2 2 2 2 SLIDE Myb_DNA-bind_7 PF15963.5 CCM02807.1 - 0.0012 18.7 0.0 5.1 7.1 0.0 3.8 2 1 2 4 4 4 1 Myb DNA-binding like Rap1_C PF11626.8 CCM02807.1 - 0.0015 18.5 0.4 1.2 9.3 0.0 3.2 1 1 2 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Atg29_N PF18388.1 CCM02807.1 - 0.0055 16.5 2.0 8.5 6.3 0.0 3.5 3 0 0 3 3 3 2 Atg29 N-terminal domain TAF8_C PF10406.9 CCM02808.1 - 3.6e-09 37.0 2.6 3.6e-09 37.0 2.6 2.4 3 1 0 3 3 3 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 CCM02808.1 - 0.00021 21.2 0.0 0.0025 17.8 0.0 2.1 1 1 0 1 1 1 1 Bromodomain associated Aminotran_3 PF00202.21 CCM02809.1 - 1.1e-96 324.0 0.0 1.7e-96 323.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CCM02810.1 - 3e-73 247.1 0.0 4.1e-73 246.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CCM02810.1 - 3.8e-05 22.4 0.0 6.3e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCM02810.1 - 4.7e-05 22.5 0.0 0.00012 21.2 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Pertussis_S1 PF02917.14 CCM02810.1 - 0.0043 16.9 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 Pertussis toxin, subunit 1 Preseq_ALAS PF09029.10 CCM02810.1 - 5.5 7.5 11.9 3.4e+02 1.7 11.9 2.8 1 1 0 1 1 1 0 5-aminolevulinate synthase presequence DUF2373 PF10180.9 CCM02811.1 - 5.5e-18 64.6 0.1 1.1e-17 63.6 0.1 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Arf PF00025.21 CCM02812.1 - 4.2e-71 238.0 0.0 4.9e-71 237.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCM02812.1 - 1.6e-14 53.7 0.0 2.1e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CCM02812.1 - 1.2e-13 51.3 0.0 1.6e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CCM02812.1 - 1.4e-12 47.5 0.1 1.1e-07 31.4 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CCM02812.1 - 6.2e-10 38.9 0.0 6.8e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CCM02812.1 - 6.8e-09 35.4 0.0 8.6e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM02812.1 - 0.0014 18.7 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase WD40 PF00400.32 CCM02813.1 - 3e-17 62.7 10.0 0.00039 21.2 0.5 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02813.1 - 9.9e-06 25.8 0.1 0.037 14.3 0.0 4.2 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Iso_dh PF00180.20 CCM02814.1 - 6.2e-100 334.7 0.0 7.1e-100 334.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Abhydrolase_1 PF00561.20 CCM02816.1 - 4.7e-23 82.2 0.0 8.8e-22 78.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM02816.1 - 2.2e-17 64.4 0.5 6.6e-17 62.9 0.5 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM02816.1 - 2.7e-16 59.6 0.0 2.2e-12 46.8 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 CCM02816.1 - 3.9e-06 26.7 0.0 9.3e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.13 CCM02816.1 - 7.6e-06 25.9 0.0 0.006 16.5 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold BAAT_C PF08840.11 CCM02816.1 - 0.00015 21.7 0.0 0.08 12.8 0.0 2.1 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 CCM02816.1 - 0.00046 19.8 0.0 0.0016 18.1 0.0 1.8 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 CCM02816.1 - 0.00082 19.3 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Peptidase_S9 PF00326.21 CCM02816.1 - 0.00087 18.8 0.0 0.95 8.9 0.0 2.5 3 0 0 3 3 3 2 Prolyl oligopeptidase family UPF0227 PF05728.12 CCM02816.1 - 0.002 18.1 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_2 PF02230.16 CCM02816.1 - 0.0025 17.6 0.0 0.08 12.7 0.0 2.6 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase DUF915 PF06028.11 CCM02816.1 - 0.018 14.4 0.0 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S15 PF02129.18 CCM02816.1 - 0.02 14.5 0.0 1.5 8.4 0.0 2.3 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) PGAP1 PF07819.13 CCM02816.1 - 0.033 13.9 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Folate_carrier PF01770.18 CCM02816.1 - 0.047 12.4 0.0 0.064 12.0 0.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier Ndr PF03096.14 CCM02816.1 - 0.056 12.1 0.0 0.092 11.4 0.0 1.3 1 0 0 1 1 1 0 Ndr family DUF2048 PF09752.9 CCM02816.1 - 0.082 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Abhydrolase domain containing 18 DLH PF01738.18 CCM02816.1 - 0.1 12.1 0.1 5.1 6.6 0.0 2.5 2 1 1 3 3 3 0 Dienelactone hydrolase family Ribosomal_S11 PF00411.19 CCM02817.1 - 4.9e-08 33.4 0.0 7e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 UCR_UQCRX_QCR9 PF05365.12 CCM02818.1 - 1.9e-25 88.6 3.8 2.1e-25 88.4 3.8 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like IPK PF03770.16 CCM02819.1 - 8.1e-51 172.7 0.0 1.2e-50 172.1 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase RRM_1 PF00076.22 CCM02820.1 - 3.4e-16 58.8 0.0 5.3e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_14 PF13428.6 CCM02821.1 - 0.00033 21.2 1.8 1.3 10.0 0.3 3.8 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCM02821.1 - 0.0063 16.5 0.0 9.1 6.7 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM02821.1 - 0.012 16.2 0.0 0.22 12.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCM02821.1 - 0.015 15.1 0.0 7 6.6 0.1 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCM02821.1 - 0.029 14.7 0.3 8.7 6.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCM02821.1 - 0.049 14.1 0.3 7.1 7.2 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat F-box-like PF12937.7 CCM02822.1 - 2.3e-06 27.4 0.5 5.6e-06 26.1 0.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM02822.1 - 0.13 12.2 0.2 0.47 10.4 0.2 2.0 1 1 0 1 1 1 0 F-box domain Ribosomal_L19 PF01245.20 CCM02824.1 - 6.1e-14 51.9 0.0 1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 Fungal_trans PF04082.18 CCM02825.1 - 2.9e-33 115.1 0.0 4.1e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM02825.1 - 7.3e-09 35.6 12.8 1.6e-08 34.5 12.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 CCM02825.1 - 0.0011 18.6 1.1 0.0039 16.9 1.1 1.9 1 0 0 1 1 1 1 Integrin plexin domain Acyl-CoA_dh_1 PF00441.24 CCM02826.1 - 4.8e-32 111.2 0.6 7.6e-32 110.6 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCM02826.1 - 1.4e-17 63.6 0.0 4.5e-17 62.0 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CCM02826.1 - 2.9e-12 47.0 0.6 5e-12 46.2 0.6 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CCM02826.1 - 8.9e-12 45.7 0.0 1.9e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Hemerythrin PF01814.23 CCM02827.1 - 0.015 16.0 1.5 0.026 15.2 1.5 1.3 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain CorA PF01544.18 CCM02827.1 - 0.19 11.0 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ECH_1 PF00378.20 CCM02828.1 - 6e-19 68.3 0.0 7.4e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCM02828.1 - 0.00039 20.0 0.0 0.00069 19.2 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF2423 PF10338.9 CCM02829.1 - 4.5e-16 58.8 4.6 6.6e-16 58.3 4.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Laps PF10169.9 CCM02829.1 - 0.016 15.8 0.2 0.02 15.4 0.2 1.2 1 0 0 1 1 1 0 Learning-associated protein TBCC PF07986.12 CCM02830.1 - 0.098 12.4 0.5 0.18 11.5 0.5 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor C DUF4013 PF13197.6 CCM02831.1 - 0.0047 16.8 3.2 0.0047 16.8 3.2 2.9 1 1 1 2 2 2 1 Protein of unknown function (DUF4013) DUF4064 PF13273.6 CCM02831.1 - 0.21 11.9 9.7 2 8.7 0.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) BOP1NT PF08145.12 CCM02832.1 - 2.3e-104 348.9 10.1 3.3e-104 348.4 10.1 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 CCM02832.1 - 5.6e-20 71.3 4.8 0.00034 21.3 0.1 5.9 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02832.1 - 3.2e-06 27.3 0.1 0.57 10.5 0.0 4.3 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 CCM02832.1 - 0.15 10.3 0.0 0.22 9.8 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz FCP1_C PF09309.10 CCM02832.1 - 1.5 8.6 0.0 1.5 8.6 0.0 3.4 3 0 0 3 3 3 0 FCP1, C-terminal TRAP_alpha PF03896.16 CCM02832.1 - 6 6.0 9.7 11 5.1 9.7 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Actin PF00022.19 CCM02833.1 - 1.2e-115 386.5 0.0 1.3e-115 386.3 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CCM02833.1 - 2.4e-07 29.9 0.0 0.018 13.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Ncstrn_small PF18266.1 CCM02833.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Nicastrin small lobe RRM_Rrp7 PF17799.1 CCM02834.1 - 0.22 11.3 0.1 0.44 10.3 0.1 1.5 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain TFIIA PF03153.13 CCM02834.1 - 8.6 6.2 17.3 15 5.5 17.3 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sedlin_N PF04628.13 CCM02835.1 - 3.2e-36 124.3 0.0 3.5e-35 121.0 0.0 1.9 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 CCM02835.1 - 1.1e-08 35.1 0.0 1.4e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Sybindin-like family Spt5-NGN PF03439.13 CCM02835.1 - 0.061 13.2 0.0 0.44 10.5 0.0 2.1 1 1 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section Rhomboid PF01694.22 CCM02836.1 - 2.1e-25 89.5 11.6 2.2e-25 89.4 9.5 1.9 2 0 0 2 2 2 1 Rhomboid family YIF1 PF03878.15 CCM02837.1 - 0.0045 16.5 3.4 0.4 10.2 3.1 2.4 1 1 0 1 1 1 1 YIF1 AAA PF00004.29 CCM02838.1 - 7.4e-32 110.5 0.0 1.4e-31 109.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM02838.1 - 2.1e-07 31.5 0.0 5.7e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCM02838.1 - 9.9e-07 29.1 0.1 1.6e-05 25.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 CCM02838.1 - 1.5e-05 24.3 0.0 0.0084 15.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_2 PF07724.14 CCM02838.1 - 2e-05 24.8 0.0 5.3e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 CCM02838.1 - 2.3e-05 24.4 0.0 4.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCM02838.1 - 3.4e-05 24.4 0.0 6.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCM02838.1 - 8.8e-05 22.7 0.0 0.00026 21.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCM02838.1 - 0.00011 22.1 0.1 0.00035 20.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCM02838.1 - 0.00019 21.3 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 CCM02838.1 - 0.00029 20.8 0.1 0.17 11.8 0.1 2.2 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea AAA_5 PF07728.14 CCM02838.1 - 0.00032 20.7 0.2 0.001 19.1 0.1 2.0 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Cytidylate_kin PF02224.18 CCM02838.1 - 0.00041 20.1 0.1 0.0013 18.5 0.0 1.9 2 0 0 2 2 2 1 Cytidylate kinase TIP49 PF06068.13 CCM02838.1 - 0.00064 19.0 0.0 0.00097 18.4 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 CCM02838.1 - 0.001 18.7 1.5 0.36 10.4 0.0 2.6 2 1 0 3 3 2 1 AAA domain NACHT PF05729.12 CCM02838.1 - 0.0012 18.8 0.1 0.0027 17.6 0.1 1.8 1 1 0 1 1 1 1 NACHT domain TsaE PF02367.17 CCM02838.1 - 0.0021 18.1 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CCM02838.1 - 0.0021 17.8 0.1 0.012 15.3 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 CCM02838.1 - 0.0032 17.7 0.0 0.0079 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 CCM02838.1 - 0.0039 16.9 0.0 0.0072 16.1 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 CCM02838.1 - 0.0044 16.8 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CCM02838.1 - 0.0045 17.4 0.0 0.012 16.0 0.0 1.7 2 0 0 2 2 1 1 RNA helicase AAA_24 PF13479.6 CCM02838.1 - 0.0077 16.0 0.0 0.025 14.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCM02838.1 - 0.0087 15.8 0.0 0.024 14.4 0.0 1.8 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 CCM02838.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 CCM02838.1 - 0.016 14.6 0.0 0.047 13.1 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 CCM02838.1 - 0.02 15.4 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 CCM02838.1 - 0.027 14.9 0.0 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 CCM02838.1 - 0.04 13.4 0.0 0.3 10.5 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 CCM02838.1 - 0.042 14.2 0.6 0.24 11.7 0.0 2.2 1 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CCM02838.1 - 0.045 13.6 0.1 0.15 11.9 0.0 1.9 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 CCM02838.1 - 0.058 12.7 0.0 0.2 10.9 0.0 1.8 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain CPT PF07931.12 CCM02838.1 - 0.06 13.2 0.1 0.18 11.7 0.0 1.8 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein Rad17 PF03215.15 CCM02838.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain KAP_NTPase PF07693.14 CCM02838.1 - 0.16 11.2 0.0 4 6.6 0.0 2.0 1 1 1 2 2 2 0 KAP family P-loop domain DUF2075 PF09848.9 CCM02838.1 - 0.17 11.1 0.0 0.32 10.2 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Rdx PF10262.9 CCM02839.1 - 2.2e-22 79.0 0.0 3.2e-21 75.3 0.0 2.1 1 1 1 2 2 2 1 Rdx family SNARE_assoc PF09335.11 CCM02840.1 - 1.7e-16 60.7 7.6 1.7e-16 60.7 7.6 2.5 2 1 1 3 3 3 1 SNARE associated Golgi protein DUF2076 PF09849.9 CCM02841.1 - 0.035 14.2 0.2 0.048 13.7 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PEX11 PF05648.14 CCM02842.1 - 2.1e-13 50.3 0.7 2.4e-06 27.2 0.0 2.6 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) Tctex-1 PF03645.13 CCM02843.1 - 7.6e-07 29.3 0.0 9.3e-07 29.0 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family DUF2939 PF11159.8 CCM02843.1 - 0.17 12.3 0.0 0.21 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2939) PPR_2 PF13041.6 CCM02845.1 - 2.2e-05 24.5 0.0 0.0015 18.7 0.0 3.0 3 0 0 3 3 3 1 PPR repeat family PPR_3 PF13812.6 CCM02845.1 - 0.13 12.3 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Pentatricopeptide repeat domain CLASP_N PF12348.8 CCM02847.1 - 1.2e-73 247.5 0.0 1.6e-68 230.6 0.0 2.4 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 CCM02847.1 - 4.2e-06 26.6 0.2 2.6 8.5 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 CCM02847.1 - 0.0015 18.8 1.3 3 8.3 0.0 4.2 3 0 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 CCM02847.1 - 0.011 16.2 0.4 21 5.8 0.1 4.2 3 0 0 3 3 3 0 HEAT-like repeat Cnd1 PF12717.7 CCM02847.1 - 0.16 12.0 0.0 25 4.8 0.0 2.7 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 SHQ1 PF04925.15 CCM02849.1 - 7.1e-55 185.3 0.0 1e-54 184.8 0.0 1.2 1 0 0 1 1 1 1 SHQ1 protein PIH1_CS PF18201.1 CCM02849.1 - 0.0097 16.3 0.0 0.024 15.0 0.0 1.6 1 0 0 1 1 1 1 PIH1 CS-like domain CS PF04969.16 CCM02849.1 - 0.015 16.3 0.0 0.03 15.3 0.0 1.5 1 0 0 1 1 1 0 CS domain Chorismate_bind PF00425.18 CCM02850.1 - 5.1e-91 304.8 0.0 8.4e-91 304.1 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CCM02850.1 - 5.2e-26 91.6 0.0 1.3e-25 90.2 0.0 1.8 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Ribosomal_S2 PF00318.20 CCM02851.1 - 2.7e-55 186.9 0.1 6.4e-32 110.5 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 HSP70 PF00012.20 CCM02852.1 - 5.1e-236 784.5 3.9 6.3e-236 784.3 3.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCM02852.1 - 7.6e-16 57.8 0.1 5.2e-15 55.1 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein BcrAD_BadFG PF01869.20 CCM02852.1 - 0.014 14.9 0.0 1.7 8.1 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family FGGY_C PF02782.16 CCM02852.1 - 0.019 14.7 0.0 0.045 13.5 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 CCM02852.1 - 0.025 13.6 0.3 0.21 10.5 0.2 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.11 CCM02852.1 - 0.09 12.0 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 StbA protein Rep_fac_C PF08542.11 CCM02853.1 - 4.5e-14 52.6 0.0 1.5e-13 51.0 0.0 1.9 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CCM02853.1 - 2.7e-13 50.5 0.0 7.9e-13 49.0 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CCM02853.1 - 1.5e-11 44.3 0.0 9.6e-10 38.5 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CCM02853.1 - 1.4e-07 31.6 0.0 4.3e-07 30.0 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 CCM02853.1 - 8.5e-06 26.0 0.0 2.3e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_22 PF13401.6 CCM02853.1 - 2.9e-05 24.4 0.0 0.0003 21.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CCM02853.1 - 5.9e-05 23.5 0.0 0.00025 21.5 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 CCM02853.1 - 0.00069 19.5 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCM02853.1 - 0.00099 19.1 0.0 0.0045 17.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCM02853.1 - 0.0012 18.6 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCM02853.1 - 0.0012 18.6 0.0 0.0031 17.3 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CCM02853.1 - 0.0044 16.4 0.0 0.11 11.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CCM02853.1 - 0.0066 16.2 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCM02853.1 - 0.013 15.0 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 CCM02853.1 - 0.02 14.7 0.3 0.78 9.5 0.0 2.9 3 1 0 4 4 4 0 DEAD/DEAH box helicase AAA_23 PF13476.6 CCM02853.1 - 0.026 15.0 0.0 0.046 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CCM02853.1 - 0.041 14.2 0.0 0.37 11.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 CCM02853.1 - 0.043 13.8 0.0 0.25 11.3 0.0 1.9 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 CCM02853.1 - 0.068 13.7 0.0 0.17 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF5338 PF17273.2 CCM02853.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5338) DUF2075 PF09848.9 CCM02853.1 - 0.13 11.4 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.13 CCM02853.1 - 0.16 11.1 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CAF1A PF12253.8 CCM02854.1 - 1.4e-22 79.6 3.1 1.4e-22 79.6 3.1 2.6 2 0 0 2 2 2 1 Chromatin assembly factor 1 subunit A Spc24 PF08286.11 CCM02855.1 - 1.4e-05 25.3 2.2 1.4e-05 25.3 2.2 1.8 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Sec2p PF06428.11 CCM02855.1 - 0.017 15.1 1.7 0.028 14.4 0.3 1.9 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p HMMR_N PF15905.5 CCM02855.1 - 0.017 14.6 1.7 0.022 14.2 1.7 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF4200 PF13863.6 CCM02855.1 - 0.035 14.5 0.7 0.035 14.5 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4407 PF14362.6 CCM02855.1 - 0.058 12.7 4.8 0.069 12.5 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.8 CCM02855.1 - 0.073 13.1 7.8 0.091 12.8 3.8 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ParD_antitoxin PF03693.14 CCM02855.1 - 0.1 13.0 2.5 1.4 9.3 0.5 2.2 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH KxDL PF10241.9 CCM02855.1 - 0.12 12.7 1.6 4.3 7.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein FAM76 PF16046.5 CCM02855.1 - 0.15 11.4 0.8 0.19 11.1 0.8 1.1 1 0 0 1 1 1 0 FAM76 protein ADIP PF11559.8 CCM02855.1 - 0.21 11.7 4.6 0.21 11.7 1.3 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding YscO-like PF16789.5 CCM02855.1 - 0.5 10.4 4.0 0.76 9.8 1.4 2.0 2 0 0 2 2 2 0 YscO-like protein APG6_N PF17675.1 CCM02855.1 - 0.53 10.8 10.6 1.4 9.5 10.1 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4140 PF13600.6 CCM02855.1 - 1.6 9.2 8.5 12 6.4 8.4 2.5 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Velvet PF11754.8 CCM02856.1 - 1.3e-42 146.5 0.0 1.6e-42 146.2 0.0 1.1 1 0 0 1 1 1 1 Velvet factor Bmt2 PF11968.8 CCM02857.1 - 1.5e-40 139.4 0.0 1.8e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 CCM02857.1 - 3.3e-05 23.8 0.0 4.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM02857.1 - 0.00048 20.8 0.0 0.00082 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM02857.1 - 0.0084 16.7 0.0 0.015 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FAD-oxidase_C PF02913.19 CCM02858.1 - 1.5e-56 191.9 0.0 2.9e-56 190.9 0.0 1.5 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCM02858.1 - 1e-25 90.1 0.1 3.8e-25 88.3 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain DUF3145 PF11343.8 CCM02858.1 - 0.065 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) Telomere_reg-2 PF10193.9 CCM02859.1 - 1.4e-30 105.9 0.0 3.7e-30 104.6 0.0 1.7 1 0 0 1 1 1 1 Telomere length regulation protein 5_nucleotid_C PF02872.18 CCM02861.1 - 1.6e-24 86.9 0.0 2e-23 83.3 0.0 2.3 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CCM02861.1 - 3.1e-07 31.1 0.1 5.1e-07 30.4 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PGA_cap PF09587.10 CCM02861.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap MFS_1 PF07690.16 CCM02862.1 - 1.9e-31 109.3 34.1 1.9e-31 109.3 34.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1129 PF06570.11 CCM02862.1 - 0.47 9.9 5.0 0.14 11.6 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Glyco_hydro_63 PF03200.16 CCM02864.1 - 8e-165 549.3 0.0 9.2e-164 545.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 CCM02864.1 - 3e-75 253.2 0.0 1.4e-74 251.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 CCM02864.1 - 9.8e-06 24.7 0.0 1.5e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Trehalase NYN PF01936.18 CCM02865.1 - 3.1e-20 73.2 0.0 5.2e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 NYN domain Transcrip_reg PF01709.20 CCM02866.1 - 4.2e-72 242.4 0.0 5e-72 242.2 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator SPECT1 PF18680.1 CCM02866.1 - 0.037 13.7 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Plasmodium host cell traversal SPECT1 DUF3197 PF11432.8 CCM02866.1 - 0.098 12.6 0.1 19 5.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3197) Pilus_CpaD PF09476.10 CCM02866.1 - 0.11 12.3 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) Paramyxo_NS_C PF02725.14 CCM02866.1 - 0.17 12.0 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Non-structural protein C Sulfate_transp PF00916.20 CCM02867.1 - 3.1e-112 375.1 16.6 4e-112 374.7 16.6 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CCM02867.1 - 2.2e-09 37.0 0.0 4.4e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 CCM02867.1 - 0.0004 20.8 11.4 0.0038 17.6 4.0 2.9 2 0 0 2 2 2 2 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 CCM02867.1 - 0.022 15.1 0.0 0.045 14.1 0.0 1.5 1 0 0 1 1 1 0 STAS domain WD40 PF00400.32 CCM02868.1 - 3e-25 88.0 16.7 1.2e-10 41.8 0.0 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM02868.1 - 3.9e-07 30.3 0.0 0.0065 16.8 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM02868.1 - 0.0005 19.1 0.0 0.019 13.9 0.0 2.9 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein NYN PF01936.18 CCM02869.1 - 2.5e-26 92.9 0.0 3.4e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 NYN domain adh_short PF00106.25 CCM02870.1 - 1.1e-36 126.2 0.0 1.7e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM02870.1 - 2.2e-34 119.0 0.0 4.5e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PIN_4 PF13638.6 CCM02870.1 - 1.2e-16 61.2 0.0 2.5e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 PIN domain KR PF08659.10 CCM02870.1 - 1.6e-10 41.2 0.4 3.3e-10 40.2 0.4 1.4 1 0 0 1 1 1 1 KR domain EST1_DNA_bind PF10373.9 CCM02870.1 - 9.1e-07 28.6 0.0 4e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain NAAA-beta PF15508.6 CCM02870.1 - 0.15 12.4 1.7 7.3 7.0 0.0 3.3 3 0 0 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase UCR_14kD PF02271.16 CCM02872.1 - 1.1e-40 137.6 1.6 1.3e-40 137.4 1.6 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Transketolase_N PF00456.21 CCM02873.1 - 4.1e-151 502.7 0.1 5.3e-151 502.3 0.1 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CCM02873.1 - 9.8e-45 152.4 0.0 2.1e-44 151.3 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCM02873.1 - 4.7e-12 45.9 0.0 1.1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 CCM02873.1 - 0.0076 15.2 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CCM02873.1 - 0.011 15.0 0.1 0.018 14.2 0.1 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Terpene_synth PF01397.21 CCM02873.1 - 0.017 14.8 0.1 0.029 14.1 0.1 1.3 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain DUF1538 PF07556.11 CCM02873.1 - 0.11 11.7 0.2 0.2 10.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1538) Cmc1 PF08583.10 CCM02874.1 - 3.4e-13 49.4 1.9 4.1e-13 49.2 1.9 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Glyco_hydro_31 PF01055.26 CCM02875.1 - 2.8e-112 376.1 0.6 3.4e-112 375.8 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCM02875.1 - 9.6e-17 61.1 0.1 2e-16 60.0 0.1 1.6 1 0 0 1 1 1 1 Galactose mutarotase-like PALP PF00291.25 CCM02876.1 - 1.8e-54 185.2 0.0 2.1e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Polysacc_deac_2 PF04748.13 CCM02877.1 - 0.22 10.7 0.0 0.39 9.9 0.0 1.3 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Pyridoxal_deC PF00282.19 CCM02878.1 - 2.1e-66 224.2 0.0 2.8e-66 223.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CCM02878.1 - 1.4e-05 24.2 0.1 3.1e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V DNA_pol_D_N PF18018.1 CCM02879.1 - 3e-42 143.8 0.0 5e-42 143.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 CCM02879.1 - 9e-32 110.1 0.0 1.5e-16 60.4 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase alpha/epsilon subunit B Hid1 PF12722.7 CCM02881.1 - 1.6e-169 565.7 0.0 2e-169 565.4 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 CCM02881.1 - 3.6e-89 299.9 0.0 6.3e-89 299.1 0.0 1.3 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein PAGK PF15284.6 CCM02881.1 - 0.027 14.4 1.0 5.4 7.0 0.0 3.3 2 1 1 3 3 3 0 Phage-encoded virulence factor Rad51 PF08423.11 CCM02882.1 - 1.5e-38 132.5 0.0 2.7e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 CCM02882.1 - 0.00012 21.8 0.1 0.00046 19.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 CCM02882.1 - 0.00012 21.5 0.2 0.00063 19.2 0.2 2.0 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain RecA PF00154.21 CCM02882.1 - 0.0016 18.0 0.0 0.015 14.8 0.0 2.3 2 1 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 CCM02882.1 - 0.01 15.2 5.8 0.013 14.9 0.0 2.4 3 0 0 3 3 3 0 KaiC AAA_24 PF13479.6 CCM02882.1 - 0.2 11.4 0.0 0.65 9.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain Amastin PF07344.11 CCM02883.1 - 0.037 13.9 0.6 0.048 13.5 0.6 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein Oxidored_q3 PF00499.20 CCM02883.1 - 0.087 12.5 2.3 0.11 12.2 2.3 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Atg8 PF02991.16 CCM02884.1 - 7e-52 174.0 0.1 9e-52 173.6 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CCM02884.1 - 1.3e-06 28.7 0.0 1.9e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 UQ_con PF00179.26 CCM02885.1 - 8.5e-18 64.4 0.0 1.3e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCM02885.1 - 0.08 13.2 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 RWD domain PRP21_like_P PF12230.8 CCM02886.1 - 8.3e-50 169.7 13.2 8.3e-50 169.7 13.2 2.4 2 1 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 CCM02886.1 - 3.5e-36 123.0 1.9 1.7e-17 63.1 0.1 2.9 2 0 0 2 2 2 2 Surp module ubiquitin PF00240.23 CCM02886.1 - 1.6e-10 40.6 0.0 3.2e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCM02886.1 - 0.00037 20.3 0.0 0.00082 19.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf_UBZ PF18439.1 CCM02886.1 - 0.00055 19.5 0.3 0.0011 18.5 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger zf-CpG_bind_C PF12269.8 CCM02886.1 - 0.049 13.4 1.5 0.19 11.5 1.5 1.9 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain DUF2407 PF10302.9 CCM02886.1 - 0.55 10.8 0.1 0.55 10.8 0.1 2.7 3 0 0 3 3 3 0 DUF2407 ubiquitin-like domain CMS1 PF14617.6 CCM02887.1 - 9.9e-78 261.0 0.7 1.2e-77 260.7 0.7 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit RNase_T PF00929.24 CCM02888.1 - 7.4e-10 39.6 0.0 1.2e-09 38.9 0.0 1.3 1 0 0 1 1 1 1 Exonuclease LktC PF06261.11 CCM02889.1 - 0.00095 19.1 0.1 1.1 9.2 0.1 2.3 2 0 0 2 2 2 2 Actinobacillus actinomycetemcomitans leukotoxin activator LktC FAM196 PF15265.6 CCM02889.1 - 3.8 6.9 6.4 5.2 6.5 6.4 1.1 1 0 0 1 1 1 0 FAM196 family Ndc80_HEC PF03801.13 CCM02890.1 - 4.9e-27 94.4 0.0 1.2e-26 93.2 0.0 1.6 1 0 0 1 1 1 1 HEC/Ndc80p family DUF5595 PF18077.1 CCM02890.1 - 0.00048 20.1 4.8 0.00048 20.1 4.8 3.9 3 1 1 4 4 4 1 Domain of unknown function (DUF5595) HsbA PF12296.8 CCM02890.1 - 0.23 11.9 2.5 4.4 7.8 0.4 3.4 3 1 1 4 4 4 0 Hydrophobic surface binding protein A Plasmid_RAQPRD PF09686.10 CCM02890.1 - 4.4 7.6 10.2 0.13 12.5 0.3 3.1 3 0 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Mog1 PF04603.12 CCM02891.1 - 7.3e-38 130.0 0.0 8.8e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein NRBF2_MIT PF17169.4 CCM02892.1 - 4e-05 23.7 0.5 4e-05 23.7 0.5 2.4 2 0 0 2 2 2 1 MIT domain of nuclear receptor-binding factor 2 DUF2383 PF09537.10 CCM02892.1 - 8.9e-05 22.8 5.2 0.0051 17.1 0.3 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF2383) PaREP1 PF05942.11 CCM02892.1 - 9.2e-05 22.3 0.2 9.2e-05 22.3 0.2 2.1 2 0 0 2 2 2 1 Archaeal PaREP1/PaREP8 family TSC22 PF01166.18 CCM02892.1 - 2.6 8.4 6.8 23 5.4 1.3 3.2 3 1 0 3 3 3 0 TSC-22/dip/bun family Cnn_1N PF07989.11 CCM02892.1 - 6.1 7.1 14.4 18 5.5 0.3 3.4 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 Fib_alpha PF08702.10 CCM02892.1 - 7.2 6.8 9.7 20 5.4 1.9 3.0 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family WD40_alt PF14077.6 CCM02892.1 - 8.9 6.3 5.8 13 5.8 3.6 2.1 2 0 0 2 2 2 0 Alternative WD40 repeat motif Cpn60_TCP1 PF00118.24 CCM02894.1 - 1.3e-148 495.7 9.7 1.4e-148 495.6 9.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sua5_yciO_yrdC PF01300.18 CCM02894.1 - 0.0005 19.6 0.2 0.0012 18.4 0.0 1.7 2 0 0 2 2 2 1 Telomere recombination ATP-synt_Eps PF04627.13 CCM02894.1 - 3.1 7.9 4.4 1.5 8.9 0.1 2.6 3 0 0 3 3 3 0 Mitochondrial ATP synthase epsilon chain TPR_2 PF07719.17 CCM02895.1 - 3.9e-29 98.4 5.9 0.00035 20.5 0.0 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 CCM02895.1 - 1.4e-25 88.0 5.1 3.4e-05 23.5 0.0 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.6 CCM02895.1 - 2.4e-21 76.0 5.3 1.5e-05 25.4 0.0 6.0 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 CCM02895.1 - 5.6e-16 58.9 25.0 0.00022 21.8 0.3 7.0 6 1 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 CCM02895.1 - 1.6e-14 52.8 0.2 0.51 10.7 0.0 8.0 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCM02895.1 - 3.9e-14 51.9 0.5 0.044 14.2 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM02895.1 - 6.8e-14 51.3 4.5 0.015 15.0 0.0 6.8 6 1 1 7 7 7 3 TPR repeat TPR_14 PF13428.6 CCM02895.1 - 2.2e-13 49.8 14.0 0.012 16.3 0.0 8.6 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCM02895.1 - 9e-13 48.0 5.8 1.5 9.6 0.0 7.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 CCM02895.1 - 1e-10 41.7 9.5 0.0047 17.2 0.1 5.8 2 1 3 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM02895.1 - 5.9e-09 36.0 7.6 0.077 13.2 0.0 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 CCM02895.1 - 1e-07 32.0 14.7 0.002 18.2 0.6 4.8 2 2 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CCM02895.1 - 2.5e-06 27.1 9.8 7.3 6.9 0.0 7.8 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCM02895.1 - 3.9e-05 23.0 10.8 0.057 12.6 0.1 4.2 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_20 PF14561.6 CCM02895.1 - 0.0039 17.5 0.3 2.6 8.5 0.1 4.5 3 2 3 6 6 6 1 Tetratricopeptide repeat PPTA PF01239.22 CCM02895.1 - 0.019 14.7 0.1 0.75 9.6 0.1 2.7 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat ChAPs PF09295.10 CCM02895.1 - 0.057 12.4 0.0 5.4 5.9 0.0 2.3 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 CCM02895.1 - 4.6 7.2 13.5 16 5.5 0.2 5.6 7 0 0 7 7 6 0 Tetratricopeptide repeat SRR1 PF07985.12 CCM02897.1 - 8.5e-20 70.6 0.6 1.5e-19 69.8 0.6 1.4 1 0 0 1 1 1 1 SRR1 UDPG_MGDP_dh_C PF03720.15 CCM02897.1 - 0.014 15.8 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Pre-PUA PF17832.1 CCM02898.1 - 3.2e-27 95.0 0.1 4.5e-27 94.6 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CCM02898.1 - 5e-15 55.2 0.0 8.3e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 CCM02898.1 - 0.028 14.7 0.0 0.052 13.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) Peptidase_C53 PF05550.11 CCM02898.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Pestivirus Npro endopeptidase C53 CRM1_C PF08767.11 CCM02899.1 - 5.5e-132 439.8 0.1 5.5e-132 439.8 0.1 3.7 4 1 0 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 CCM02899.1 - 5.7e-42 143.3 8.0 5.1e-41 140.2 7.9 2.9 2 0 0 2 2 2 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 CCM02899.1 - 1.8e-33 114.0 4.8 4.5e-33 112.7 4.8 1.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 CCM02899.1 - 5.9e-31 106.3 2.6 1.8e-30 104.8 1.2 2.8 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 CCM02899.1 - 3.8e-19 67.9 2.4 3.8e-19 67.9 2.4 2.4 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 CCM02899.1 - 2.1e-09 37.1 0.0 9e-09 35.1 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF3385 PF11865.8 CCM02899.1 - 0.043 13.7 0.0 0.49 10.3 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) TraH PF06122.11 CCM02899.1 - 0.078 12.2 0.0 0.21 10.8 0.0 1.7 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein Vac14_Fab1_bd PF12755.7 CCM02899.1 - 0.16 12.6 0.9 11 6.6 0.0 3.7 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Kdo PF06293.14 CCM02900.1 - 1.8e-07 30.8 0.0 2.2e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CCM02900.1 - 0.014 14.8 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain RIO1 PF01163.22 CCM02900.1 - 0.14 11.8 0.0 0.61 9.7 0.0 1.8 2 0 0 2 2 2 0 RIO1 family MFS_1 PF07690.16 CCM02901.1 - 4.6e-25 88.3 37.4 3.3e-20 72.3 11.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase_Tyr PF07714.17 CCM02902.1 - 2.2e-38 132.0 0.0 3.7e-38 131.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM02902.1 - 1.8e-28 99.6 0.0 3.4e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain MFS_1 PF07690.16 CCM02902.1 - 2.4e-13 49.8 29.8 2.4e-13 49.8 29.8 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily Peptidase_C101 PF16218.5 CCM02902.1 - 0.12 11.6 1.5 0.18 11.0 1.5 1.2 1 0 0 1 1 1 0 Peptidase family C101 Thiol_cytolysin PF01289.19 CCM02902.1 - 0.12 11.2 0.2 0.19 10.6 0.2 1.1 1 0 0 1 1 1 0 Thiol-activated cytolysin DUF5353 PF17304.2 CCM02902.1 - 1.4 8.7 4.5 0.58 9.9 0.5 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5353) Pkinase_Tyr PF07714.17 CCM02903.1 - 9.9e-37 126.6 0.0 1.9e-36 125.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM02903.1 - 2.9e-25 89.1 0.0 6.7e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CCM02903.1 - 0.039 13.3 0.0 0.1 11.9 0.0 1.7 1 0 0 1 1 1 0 Kinase-like Dicistro_VP4 PF11492.8 CCM02903.1 - 0.073 13.0 0.3 0.19 11.7 0.1 1.8 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 NB-ARC PF00931.22 CCM02903.1 - 0.15 11.2 1.8 0.3 10.3 1.8 1.4 1 0 0 1 1 1 0 NB-ARC domain Zn_clus PF00172.18 CCM02904.1 - 0.00052 20.1 15.8 0.00076 19.6 15.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TGT PF01702.18 CCM02905.1 - 2e-18 66.7 0.1 3.1e-18 66.1 0.1 1.2 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF1945 PF09178.10 CCM02905.1 - 0.21 11.8 1.4 0.25 11.5 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1945) DUF3684 PF12449.8 CCM02906.1 - 0 1256.5 0.0 0 1256.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 CCM02906.1 - 0.027 14.3 0.1 0.15 11.9 0.1 2.1 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase His_Phos_2 PF00328.22 CCM02907.1 - 8.6e-46 157.0 0.0 1.2e-45 156.5 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Pkinase PF00069.25 CCM02908.1 - 4.7e-53 180.2 0.0 7e-53 179.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02908.1 - 3.5e-18 65.8 0.0 6.6e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM02908.1 - 0.0084 16.1 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCM02908.1 - 0.026 14.1 0.3 0.057 13.0 0.3 1.6 1 0 0 1 1 1 0 RIO1 family AAA PF00004.29 CCM02909.1 - 1.6e-40 138.6 0.0 3.9e-40 137.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCDHK_Adom3 PF10436.9 CCM02909.1 - 1.5e-36 125.7 0.0 2.5e-36 124.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CCM02909.1 - 3.5e-07 30.7 0.0 5.7e-05 23.6 0.0 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_lid_3 PF17862.1 CCM02909.1 - 1.8e-05 24.4 0.1 7.2e-05 22.5 0.1 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CCM02909.1 - 0.00016 21.7 0.0 0.00049 20.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCM02909.1 - 0.00032 21.0 0.0 0.01 16.1 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 CCM02909.1 - 0.00088 19.4 0.0 0.002 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 CCM02909.1 - 0.0011 18.2 0.0 0.0042 16.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 CCM02909.1 - 0.003 18.0 0.1 0.03 14.7 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CCM02909.1 - 0.0094 15.7 0.0 0.037 13.8 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CCM02909.1 - 0.019 15.2 0.0 0.058 13.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 CCM02909.1 - 0.036 13.6 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 CCM02909.1 - 0.038 14.1 0.0 0.08 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCM02909.1 - 0.095 13.2 0.0 0.4 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CCM02909.1 - 0.12 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CCM02909.1 - 0.14 11.6 0.0 0.33 10.3 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CCM02909.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CCM02909.1 - 0.15 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 CCM02909.1 - 0.15 12.2 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ATP-synt_ab PF00006.25 CCM02910.1 - 9.4e-108 358.7 0.0 1.4e-107 358.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 CCM02910.1 - 1.4e-41 141.2 0.0 2.5e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension Fasciclin PF02469.22 CCM02910.1 - 2.4e-30 105.4 0.2 5.2e-13 49.3 0.0 4.5 4 0 0 4 4 4 4 Fasciclin domain ATP-synt_ab_N PF02874.23 CCM02910.1 - 6.4e-14 52.2 3.1 1.4e-13 51.1 3.1 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain IPPT PF01715.17 CCM02911.1 - 4.8e-56 190.1 0.0 1.5e-55 188.5 0.0 1.7 1 1 0 1 1 1 1 IPP transferase AAA_18 PF13238.6 CCM02911.1 - 0.00042 20.9 0.0 0.018 15.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCM02911.1 - 0.0072 15.9 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCM02911.1 - 0.01 16.1 0.0 0.036 14.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCM02911.1 - 0.026 14.9 0.0 0.064 13.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 CCM02911.1 - 0.032 14.0 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 CCM02911.1 - 0.13 12.7 0.6 2.1 8.7 0.5 2.7 1 1 1 2 2 2 0 AAA ATPase domain KTI12 PF08433.10 CCM02911.1 - 0.13 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Ribosomal_L27A PF00828.19 CCM02912.1 - 6.9e-35 120.5 0.1 9.3e-35 120.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A PRP38 PF03371.15 CCM02913.1 - 3.5e-57 193.0 0.6 6e-57 192.3 0.6 1.3 1 1 0 1 1 1 1 PRP38 family PHD PF00628.29 CCM02914.1 - 2.3e-05 24.2 3.6 2.3e-05 24.2 3.6 1.9 2 0 0 2 2 2 1 PHD-finger TORC_C PF12886.7 CCM02914.1 - 0.042 14.4 0.7 0.14 12.7 0.7 1.8 2 0 0 2 2 2 0 Transducer of regulated CREB activity, C terminus BcrAD_BadFG PF01869.20 CCM02915.1 - 5.5e-10 39.2 0.0 2.3e-09 37.1 0.0 2.1 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family PGM_PMM_II PF02879.16 CCM02916.1 - 1.3e-21 77.1 0.0 2.8e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_I PF02878.16 CCM02916.1 - 7.7e-20 71.0 0.1 4e-18 65.5 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CCM02916.1 - 1.4e-18 67.1 0.1 2.8e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 CCM02916.1 - 8.3e-05 22.7 0.0 0.00024 21.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Proteasome PF00227.26 CCM02917.1 - 3.4e-37 127.8 1.1 5.6e-28 97.7 0.2 2.2 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 CCM02917.1 - 3.4e-14 52.2 0.1 8.5e-14 50.9 0.1 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Orthopox_B11R PF07033.11 CCM02917.1 - 0.088 12.6 0.4 2.1 8.2 0.2 2.7 2 0 0 2 2 2 0 Orthopoxvirus B11R protein Peptidase_C78 PF07910.13 CCM02918.1 - 1.1e-31 110.0 0.0 2.8e-31 108.7 0.0 1.6 2 0 0 2 2 2 1 Peptidase family C78 MAT1 PF06391.13 CCM02919.1 - 1.7e-57 194.6 16.0 2e-57 194.4 16.0 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 CCM02919.1 - 6.6e-07 29.1 1.6 1.1e-06 28.5 1.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM02919.1 - 0.034 14.0 1.3 0.053 13.4 1.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM02919.1 - 0.12 12.2 3.3 0.22 11.4 3.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TEX13 PF15186.6 CCM02919.1 - 0.15 11.8 7.6 0.21 11.3 7.6 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family zf-C3HC4 PF00097.25 CCM02919.1 - 0.62 10.0 2.7 1.1 9.2 2.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CDC45 PF02724.14 CCM02919.1 - 1.7 6.9 9.6 2 6.6 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein FlgT_N PF16548.5 CCM02919.1 - 8 7.1 9.3 0.51 10.9 0.7 2.8 3 0 0 3 3 3 0 Flagellar assembly protein T, N-terminal domain Pkinase PF00069.25 CCM02920.1 - 6.7e-65 219.1 0.0 8.9e-65 218.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain LigB PF02900.18 CCM02920.1 - 9e-32 110.2 0.0 1.2e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Pkinase_Tyr PF07714.17 CCM02920.1 - 2.6e-28 99.0 0.0 3.7e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM02920.1 - 0.0079 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Brix PF04427.18 CCM02921.1 - 1e-42 146.5 0.0 1.4e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 Brix domain Nop25 PF09805.9 CCM02921.1 - 0.071 13.6 12.8 0.14 12.6 12.8 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) TFIIA PF03153.13 CCM02921.1 - 1.3 8.9 12.9 1.8 8.5 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cyto_heme_lyase PF01265.17 CCM02922.1 - 5.4e-46 157.5 5.7 2.5e-44 152.0 5.7 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase MFS_1 PF07690.16 CCM02926.1 - 1.4e-38 132.8 30.3 2e-38 132.2 30.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM02926.1 - 4.4e-17 62.1 4.5 4.4e-17 62.1 4.5 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM02927.1 - 1.8e-40 138.9 21.2 1.8e-40 138.9 21.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM02927.1 - 2.2e-15 56.5 5.2 2.2e-15 56.5 5.2 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter YbgT_YccB PF08173.11 CCM02927.1 - 0.1 12.7 2.5 0.24 11.6 0.6 2.7 2 0 0 2 2 2 0 Membrane bound YbgT-like protein DUF389 PF04087.14 CCM02927.1 - 0.31 11.1 0.0 0.31 11.1 0.0 3.4 4 1 0 4 4 4 0 Domain of unknown function (DUF389) NMO PF03060.15 CCM02928.1 - 3.8e-18 66.0 0.2 6.8e-18 65.1 0.2 1.4 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CCM02928.1 - 0.00019 20.5 0.0 0.00024 20.2 0.0 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain WD40 PF00400.32 CCM02929.1 - 1.1e-12 48.2 3.5 0.0061 17.4 0.1 5.3 6 1 0 6 6 6 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 CCM02929.1 - 0.0046 15.8 0.3 1.2 7.8 0.1 2.3 1 1 1 2 2 2 2 Nup133 N terminal like Nup160 PF11715.8 CCM02929.1 - 0.11 11.1 0.8 0.83 8.2 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 LURAP PF14854.6 CCM02930.1 - 0.073 13.0 0.7 0.34 10.9 0.1 2.1 1 1 1 2 2 2 0 Leucine rich adaptor protein TPR_14 PF13428.6 CCM02931.1 - 5.4e-09 36.1 18.9 8.1 7.6 0.1 11.3 8 3 4 12 12 12 2 Tetratricopeptide repeat Suf PF05843.14 CCM02931.1 - 1e-05 25.7 12.3 8.8e-05 22.6 2.9 4.2 2 1 1 4 4 4 1 Suppressor of forked protein (Suf) TPR_2 PF07719.17 CCM02931.1 - 0.0006 19.7 16.4 0.29 11.4 0.1 7.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCM02931.1 - 0.0025 18.1 3.7 23 5.4 0.0 5.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCM02931.1 - 0.0031 18.0 5.7 4.3 7.9 0.1 5.7 6 1 0 6 6 6 1 Tetratricopeptide repeat NRDE-2 PF08424.10 CCM02931.1 - 0.0055 15.9 11.2 0.29 10.2 0.6 4.8 3 2 2 5 5 5 2 NRDE-2, necessary for RNA interference Mad3_BUB1_I PF08311.12 CCM02931.1 - 0.0063 16.5 10.0 4.5 7.3 0.3 5.8 6 0 0 6 6 6 1 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 CCM02931.1 - 0.048 13.9 6.5 32 5.1 0.2 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 CCM02931.1 - 0.07 13.0 1.1 36 4.4 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 CCM02931.1 - 0.16 12.5 7.0 1.2e+02 3.4 0.0 6.2 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCM02931.1 - 0.35 11.6 9.7 11 6.7 0.0 5.1 6 1 0 6 6 5 0 Tetratricopeptide repeat HAT PF02184.16 CCM02931.1 - 1.3 9.1 11.9 3.5 7.7 0.1 6.0 6 0 0 6 6 6 0 HAT (Half-A-TPR) repeat PPTA PF01239.22 CCM02932.1 - 2.8e-43 144.4 12.9 1.8e-09 37.0 1.8 5.8 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat MetW PF07021.12 CCM02932.1 - 0.018 14.7 0.1 1.8 8.1 0.0 2.5 2 1 0 2 2 2 0 Methionine biosynthesis protein MetW Ge1_WD40 PF16529.5 CCM02934.1 - 0.049 12.6 0.0 0.12 11.4 0.0 1.5 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF445 PF04286.12 CCM02934.1 - 0.13 12.1 10.1 0.2 11.4 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) SLY PF12485.8 CCM02934.1 - 0.66 10.7 6.4 1.2 9.8 2.1 2.7 2 1 0 2 2 2 0 Lymphocyte signaling adaptor protein Got1 PF04178.12 CCM02935.1 - 2e-32 112.0 18.4 2.7e-32 111.5 18.4 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family SKG6 PF08693.10 CCM02936.1 - 0.025 14.0 0.1 0.025 14.0 0.1 1.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF4131 PF13567.6 CCM02936.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TMEM154 PF15102.6 CCM02936.1 - 4.1 7.3 7.6 20 5.1 5.5 2.6 1 1 1 2 2 2 0 TMEM154 protein family HAGH_C PF16123.5 CCM02937.1 - 1.9e-19 69.9 0.0 4.1e-19 68.9 0.0 1.6 2 0 0 2 2 2 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CCM02937.1 - 6.5e-07 29.5 4.5 1.6e-05 25.0 4.5 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily SRP-alpha_N PF04086.13 CCM02938.1 - 2.8e-47 162.1 4.7 3e-45 155.4 4.7 2.2 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 CCM02938.1 - 7.1e-46 156.3 0.2 3.6e-45 154.0 0.2 2.1 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 CCM02938.1 - 1.6e-08 34.6 0.0 5.2e-08 33.0 0.0 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 CCM02938.1 - 8.3e-06 25.0 0.1 1.9e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 CCM02938.1 - 0.0051 16.6 0.0 0.18 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCM02938.1 - 0.0089 15.8 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CCM02938.1 - 0.012 15.5 0.6 0.029 14.3 0.1 1.9 2 1 0 2 2 2 0 NTPase Fer4_NifH PF00142.18 CCM02938.1 - 0.025 14.1 0.0 0.045 13.2 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_31 PF13614.6 CCM02938.1 - 0.028 14.4 0.1 1 9.3 0.0 2.6 1 1 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 CCM02938.1 - 0.054 12.7 0.6 1.5 7.9 0.1 2.2 1 1 1 2 2 2 0 Anion-transporting ATPase CbiA PF01656.23 CCM02938.1 - 0.066 13.3 0.0 0.15 12.1 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RhlB PF12300.8 CCM02938.1 - 0.095 12.8 6.3 0.21 11.7 6.3 1.5 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB AAA_16 PF13191.6 CCM02938.1 - 0.12 12.8 0.0 0.56 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 CCM02938.1 - 0.14 12.2 0.3 0.84 9.7 0.2 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase RRM_1 PF00076.22 CCM02940.1 - 3.5e-67 222.1 0.0 1.5e-18 66.4 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCM02940.1 - 0.00015 21.6 0.0 0.28 11.1 0.0 3.8 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_2 PF04059.12 CCM02940.1 - 0.00042 20.5 0.0 13 6.1 0.0 4.5 5 0 0 5 5 5 1 RNA recognition motif 2 RRM_Rrp7 PF17799.1 CCM02940.1 - 0.0018 18.1 0.0 6.2 6.6 0.0 4.1 4 0 0 4 4 4 1 Rrp7 RRM-like N-terminal domain Nup35_RRM_2 PF14605.6 CCM02940.1 - 0.0053 16.7 0.0 4 7.5 0.0 4.4 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 CCM02940.1 - 0.023 14.7 0.5 9.1 6.4 0.0 4.8 5 2 0 5 5 5 0 Limkain b1 DNA_pol_B_palm PF14792.6 CCM02941.1 - 2.8e-19 69.4 0.0 7.1e-19 68.1 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 CCM02941.1 - 1.5e-18 66.7 0.0 3.6e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 CCM02941.1 - 6.4e-10 39.3 0.1 3.5e-09 36.9 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 CCM02941.1 - 3.4e-08 33.2 0.0 1.2e-07 31.4 0.0 1.9 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda BRCT_2 PF16589.5 CCM02941.1 - 0.0021 18.5 0.0 0.0038 17.6 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Cdd1 PF11731.8 CCM02941.1 - 0.0061 16.8 0.0 0.032 14.5 0.0 2.0 2 0 0 2 2 2 1 Pathogenicity locus HHH_5 PF14520.6 CCM02941.1 - 0.096 13.3 0.0 0.47 11.1 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain Acyl-CoA_dh_1 PF00441.24 CCM02942.1 - 1.1e-23 84.1 0.1 2.1e-23 83.2 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCM02942.1 - 2e-20 72.8 0.0 3.9e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCM02942.1 - 2.8e-18 66.6 0.0 5e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCM02942.1 - 0.00028 21.2 0.1 0.0022 18.2 0.1 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CCM02942.1 - 0.016 14.9 0.0 0.033 13.9 0.0 1.5 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Nitroreductase PF00881.24 CCM02943.1 - 1.6e-14 54.4 0.0 1.9e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family MFS_1 PF07690.16 CCM02944.1 - 4e-52 177.3 45.8 9.5e-49 166.2 47.8 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCM02944.1 - 1.9e-14 53.0 22.1 2.8e-14 52.5 22.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF373 PF04123.13 CCM02944.1 - 0.0038 16.7 2.1 0.0038 16.7 2.1 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF373) Gcn1_N PF12074.8 CCM02945.1 - 1.1e-90 304.5 0.3 1.1e-90 304.5 0.3 4.4 5 0 0 5 5 5 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 CCM02945.1 - 1.7e-31 105.6 27.1 0.13 12.6 0.1 19.8 21 0 0 21 21 19 8 HEAT repeat HEAT_EZ PF13513.6 CCM02945.1 - 1.7e-28 98.6 28.3 0.0021 18.5 0.0 16.2 14 1 3 17 17 15 7 HEAT-like repeat HEAT_2 PF13646.6 CCM02945.1 - 3.4e-28 97.9 35.7 1e-05 25.8 0.1 14.5 12 2 3 16 16 16 8 HEAT repeats Cnd1 PF12717.7 CCM02945.1 - 1.6e-16 60.8 0.4 0.0044 17.1 0.0 9.1 7 1 2 10 10 9 4 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 CCM02945.1 - 4.2e-12 46.1 0.0 7.5e-05 22.4 0.0 5.9 5 0 0 5 5 5 3 CLASP N terminal Vac14_Fab1_bd PF12755.7 CCM02945.1 - 3e-07 30.9 0.1 3.4 8.3 0.0 7.4 7 1 2 9 9 8 1 Vacuolar 14 Fab1-binding region IFRD PF05004.13 CCM02945.1 - 7.3e-07 28.6 12.8 0.79 8.8 0.0 7.1 6 1 1 7 7 7 2 Interferon-related developmental regulator (IFRD) Adaptin_N PF01602.20 CCM02945.1 - 5.9e-06 25.1 10.0 0.23 10.0 0.2 7.1 9 1 0 9 9 9 2 Adaptin N terminal region Tti2 PF10521.9 CCM02945.1 - 8.7e-06 25.5 0.5 0.047 13.2 0.0 5.5 5 1 0 5 5 5 1 Tti2 family FANCI_S2 PF14676.6 CCM02945.1 - 0.00017 21.9 3.6 0.12 12.7 0.2 4.0 5 0 0 5 5 4 2 FANCI solenoid 2 DUF4042 PF13251.6 CCM02945.1 - 0.00061 19.5 0.5 1.1 8.9 0.0 4.8 4 1 0 4 4 4 1 Domain of unknown function (DUF4042) NUC173 PF08161.12 CCM02945.1 - 0.0046 16.6 1.9 0.52 9.9 0.0 5.2 5 1 0 5 5 5 1 NUC173 domain DUF3437 PF11919.8 CCM02945.1 - 0.0082 16.0 6.2 8 6.5 0.0 6.6 7 0 0 7 7 7 1 Domain of unknown function (DUF3437) Dopey_N PF04118.14 CCM02945.1 - 0.028 13.5 0.1 1.4 8.0 0.0 3.6 4 1 1 5 5 5 0 Dopey, N-terminal DUF2267 PF10025.9 CCM02945.1 - 0.17 12.2 4.8 0.47 10.7 0.6 3.6 1 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) Arm PF00514.23 CCM02945.1 - 0.4 10.8 8.8 32 4.7 0.1 6.6 7 0 0 7 7 6 0 Armadillo/beta-catenin-like repeat MMS19_N PF14500.6 CCM02945.1 - 0.48 10.0 13.9 12 5.4 0.1 7.4 8 0 0 8 8 8 0 Dos2-interacting transcription regulator of RNA-Pol-II BRAP2 PF07576.12 CCM02946.1 - 1.2e-23 83.2 0.1 6e-15 55.3 0.0 2.4 1 1 1 2 2 2 2 BRCA1-associated protein 2 zf-UBP PF02148.19 CCM02946.1 - 1.1e-16 60.9 3.4 1.8e-16 60.2 3.4 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_11 PF17123.5 CCM02946.1 - 1.4e-05 24.8 0.4 4.7e-05 23.0 0.4 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 CCM02946.1 - 8.1e-05 22.6 0.3 0.00017 21.5 0.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCM02946.1 - 0.00022 21.5 1.4 0.00045 20.5 1.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCM02946.1 - 0.0025 17.6 0.5 0.0057 16.5 0.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM02946.1 - 0.051 13.5 0.4 0.097 12.7 0.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 CCM02946.1 - 0.064 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rootletin PF15035.6 CCM02946.1 - 0.12 12.3 22.8 0.82 9.7 11.0 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion MCM3AP_GANP PF16769.5 CCM02946.1 - 0.18 10.0 10.8 0.25 9.5 10.8 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP VSG_B PF13206.6 CCM02946.1 - 0.21 10.8 8.9 0.31 10.3 8.9 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain Topoisom_I_N PF02919.15 CCM02946.1 - 0.39 10.2 6.9 0.65 9.5 6.9 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Filament PF00038.21 CCM02946.1 - 0.43 10.1 21.8 4 6.9 21.7 1.9 1 1 1 2 2 2 0 Intermediate filament protein Tho2 PF11262.8 CCM02946.1 - 0.59 9.3 10.2 1 8.5 10.2 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 SPX PF03105.19 CCM02946.1 - 1.5 8.7 12.8 3.1 7.6 12.8 1.4 1 0 0 1 1 1 0 SPX domain RasGAP_C PF03836.15 CCM02946.1 - 2 8.6 10.5 2.3 8.4 2.4 2.2 1 1 1 2 2 2 0 RasGAP C-terminus polyprenyl_synt PF00348.17 CCM02947.1 - 1.8e-58 197.6 0.0 2.5e-58 197.1 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase DUF5085 PF16895.5 CCM02947.1 - 0.045 14.1 0.0 0.27 11.6 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5085) DUF3552 PF12072.8 CCM02949.1 - 0.019 14.4 13.7 0.24 10.8 13.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) DUF390 PF04094.14 CCM02949.1 - 0.09 11.1 14.9 0.12 10.7 14.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Abi_HHR PF07815.14 CCM02949.1 - 0.093 12.9 2.5 3.3 7.9 0.3 2.4 2 0 0 2 2 2 0 Abl-interactor HHR PgaD PF13994.6 CCM02949.1 - 0.1 12.6 0.0 0.1 12.6 0.0 1.8 2 0 0 2 2 2 0 PgaD-like protein TPR_10 PF13374.6 CCM02949.1 - 2.1 8.3 12.6 1.2 9.0 0.8 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF16 PF01519.16 CCM02949.1 - 8.1 7.0 6.2 11 6.6 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Silic_transp PF03842.13 CCM02951.1 - 0.0038 15.6 0.8 0.0063 14.9 0.8 1.3 1 0 0 1 1 1 1 Silicon transporter Ndc1_Nup PF09531.10 CCM02951.1 - 3.7 6.1 8.8 5.4 5.6 8.3 1.8 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3552 PF12072.8 CCM02953.1 - 0.053 12.9 10.4 0.022 14.2 7.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DUF390 PF04094.14 CCM02953.1 - 0.27 9.5 6.5 0.37 9.0 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Mito_carr PF00153.27 CCM02954.1 - 9e-29 99.3 0.2 4.4e-13 49.0 0.0 2.7 3 0 0 3 3 3 2 Mitochondrial carrier protein F-box-like PF12937.7 CCM02955.1 - 1.2e-05 25.1 0.7 3.7e-05 23.5 0.7 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCM02955.1 - 0.057 13.9 0.9 20 5.8 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) BTB PF00651.31 CCM02956.1 - 6.6e-08 32.8 0.0 5.9e-07 29.7 0.0 2.1 1 1 0 1 1 1 1 BTB/POZ domain AMP-binding PF00501.28 CCM02957.1 - 9.9e-68 228.6 0.0 1.3e-67 228.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM02957.1 - 5.7e-13 49.6 0.1 2.5e-12 47.6 0.1 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Pkinase_fungal PF17667.1 CCM02958.1 - 3.7e-08 32.6 0.0 4.4e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase AMP-binding PF00501.28 CCM02960.1 - 3.7e-77 259.7 0.0 2.1e-76 257.2 0.0 1.8 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM02960.1 - 1.3e-10 42.1 0.0 1.8e-09 38.5 0.0 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Cyclase PF04199.13 CCM02961.1 - 6.9e-29 100.8 0.1 8.7e-29 100.5 0.1 1.1 1 0 0 1 1 1 1 Putative cyclase Sld7_C PF18596.1 CCM02962.1 - 1.1e-06 28.6 0.0 2.5e-06 27.5 0.0 1.7 1 1 0 1 1 1 1 Sld7 C-terminal domain TBPIP PF07106.13 CCM02963.1 - 0.068 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain TetR_C_11 PF16859.5 CCM02966.1 - 0.0029 17.9 1.3 0.0086 16.4 0.7 2.0 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain OPA3 PF07047.12 CCM02966.1 - 0.16 11.8 0.5 0.45 10.3 0.5 2.0 1 1 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Sulfate_transp PF00916.20 CCM02968.1 - 1.5e-82 277.4 15.7 1.5e-82 277.4 15.7 1.3 1 1 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CCM02968.1 - 4.6e-16 58.5 0.0 9.1e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CCM02968.1 - 5.1e-05 23.5 0.0 0.00012 22.4 0.0 1.7 1 0 0 1 1 1 1 STAS domain Pox_Ag35 PF03286.14 CCM02969.1 - 0.42 10.4 2.8 0.16 11.7 0.2 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Pkinase PF00069.25 CCM02970.1 - 1.9e-69 234.0 0.0 2.3e-69 233.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM02970.1 - 1.9e-36 125.7 0.0 2.5e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TP_methylase PF00590.20 CCM02971.1 - 1.7e-20 73.9 0.2 2.7e-20 73.2 0.2 1.3 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Peptidase_S8 PF00082.22 CCM02972.1 - 1.6e-32 112.9 9.6 2.8e-32 112.2 9.6 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CCM02972.1 - 1.1e-13 51.6 0.0 2.2e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Mito_carr PF00153.27 CCM02973.1 - 5.6e-66 218.5 2.9 1.3e-22 79.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Acylphosphatase PF00708.18 CCM02974.1 - 1.6e-16 60.5 0.6 1.7e-16 60.4 0.6 1.0 1 0 0 1 1 1 1 Acylphosphatase Kinesin PF00225.23 CCM02975.1 - 7.6e-56 189.4 0.0 1.2e-55 188.8 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCM02975.1 - 8.7e-10 38.7 0.0 2.2e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 CCM02975.1 - 0.0038 17.6 0.1 0.012 16.0 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain DUF2791 PF10923.8 CCM02975.1 - 0.014 14.3 0.3 0.22 10.3 0.0 2.1 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) AAA_22 PF13401.6 CCM02975.1 - 0.042 14.1 0.0 0.17 12.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCM02975.1 - 0.079 12.5 0.0 0.27 10.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Death PF00531.22 CCM02975.1 - 0.81 9.9 2.8 5.5 7.2 0.3 3.0 3 0 0 3 3 3 0 Death domain SNF2_N PF00176.23 CCM02977.1 - 1.1e-62 211.8 0.4 1.1e-62 211.8 0.4 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM02977.1 - 5.1e-17 62.2 0.0 1e-15 58.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM02977.1 - 3.7e-09 36.8 0.0 7.8e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCM02977.1 - 0.0005 19.9 0.0 0.0014 18.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 CCM02977.1 - 0.017 15.1 0.2 3 7.8 0.0 2.5 2 0 0 2 2 2 0 Flavivirus DEAD domain 3HCDH_N PF02737.18 CCM02978.1 - 1e-48 165.6 3.2 1.5e-47 161.8 3.2 2.3 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CCM02978.1 - 1.3e-08 35.4 0.3 2.5e-06 28.0 0.0 2.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CCM02978.1 - 0.0008 19.6 0.9 0.0019 18.4 0.9 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 CCM02978.1 - 0.017 15.1 0.1 0.041 13.9 0.1 1.6 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Helicase_C_2 PF13307.6 CCM02979.1 - 3.9e-49 167.1 0.0 7.1e-49 166.3 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CCM02979.1 - 4.8e-40 137.0 0.1 2.3e-33 115.3 0.0 3.3 3 1 0 3 3 3 2 DEAD_2 RF-1 PF00472.20 CCM02980.1 - 0.075 13.0 1.3 0.15 12.0 1.3 1.4 1 0 0 1 1 1 0 RF-1 domain DUF2992 PF11208.8 CCM02980.1 - 2.6 8.3 7.6 0.87 9.8 4.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) Ribosomal_60s PF00428.19 CCM02980.1 - 7.2 7.3 11.9 0.54 10.9 2.6 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein FAD_binding_3 PF01494.19 CCM02981.1 - 3.5e-82 276.5 0.0 1e-76 258.5 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CCM02981.1 - 2.2e-06 27.1 0.4 0.0012 18.2 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM02981.1 - 2.6e-05 23.5 3.3 3.5e-05 23.1 1.6 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCM02981.1 - 0.00037 20.6 0.4 0.0017 18.6 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCM02981.1 - 0.0004 19.2 0.5 0.00093 18.0 0.3 1.6 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 CCM02981.1 - 0.00041 19.7 0.0 0.00085 18.6 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 CCM02981.1 - 0.0078 15.1 0.1 0.016 14.1 0.1 1.4 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 CCM02981.1 - 0.0078 15.5 0.2 0.013 14.8 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCM02981.1 - 0.0079 15.6 0.6 0.0079 15.6 0.6 2.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 CCM02981.1 - 0.011 14.8 0.5 0.018 14.2 0.5 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 CCM02981.1 - 0.016 15.7 0.1 0.47 11.1 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM02981.1 - 0.018 14.6 0.3 0.21 11.1 0.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase FLILHELTA PF10306.9 CCM02982.1 - 1.6e-09 38.0 0.0 4.8e-09 36.5 0.0 1.8 1 1 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 CCM02982.1 - 0.014 15.9 0.0 0.023 15.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1279) Glyco_hydro_31 PF01055.26 CCM02984.1 - 1.3e-142 476.1 6.0 2e-142 475.5 6.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CCM02984.1 - 2.2e-18 66.3 0.2 7.3e-18 64.7 0.2 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 CCM02984.1 - 4.9e-06 26.7 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) F-box-like PF12937.7 CCM02985.1 - 0.0083 16.0 0.1 0.07 13.0 0.0 2.6 2 0 0 2 2 2 1 F-box-like SPOUT_MTase PF02590.17 CCM02986.1 - 0.0084 16.1 0.4 0.015 15.3 0.2 1.5 1 1 0 1 1 1 1 Predicted SPOUT methyltransferase DUF2087 PF09860.9 CCM02987.1 - 0.029 14.5 0.1 0.056 13.6 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) Cas_Cas4 PF01930.17 CCM02987.1 - 0.13 12.4 1.5 0.14 12.3 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function DUF83 APG6_N PF17675.1 CCM02987.1 - 2.9 8.4 8.4 0.61 10.6 3.6 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region BTB PF00651.31 CCM02988.1 - 3.3e-07 30.5 0.0 5.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF4519 PF15012.6 CCM02988.1 - 1.9 8.7 4.2 3.8 7.8 4.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) AAA PF00004.29 CCM02989.1 - 4.8e-15 56.1 0.0 1.2e-14 54.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM02989.1 - 0.0085 16.5 2.5 0.062 13.7 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCM02989.1 - 0.012 15.9 0.8 0.34 11.2 0.4 2.7 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCM02989.1 - 0.026 13.8 0.1 0.066 12.5 0.1 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 CCM02989.1 - 0.028 14.4 0.1 0.086 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CCM02989.1 - 0.035 14.3 0.4 2.4 8.3 0.4 2.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM02990.1 - 1.2e-10 41.6 0.0 1.2e-08 35.0 0.0 3.1 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 CCM02990.1 - 6.2e-07 30.0 2.0 2.6e-06 27.9 0.0 3.0 4 0 0 4 4 3 1 AAA ATPase domain AAA_18 PF13238.6 CCM02990.1 - 4.5e-05 24.0 0.2 0.00025 21.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCM02990.1 - 9e-05 22.8 0.0 0.00095 19.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CCM02990.1 - 0.00032 19.9 0.0 0.00089 18.5 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain Goodbye PF17109.5 CCM02990.1 - 0.0044 17.5 0.0 0.012 16.1 0.0 1.7 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain AAA PF00004.29 CCM02990.1 - 0.0058 17.1 0.0 0.027 14.9 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CCM02990.1 - 0.02 15.3 0.0 0.067 13.6 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 CCM02990.1 - 0.024 14.7 0.0 0.9 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 CCM02990.1 - 0.048 12.9 0.1 4.8 6.3 0.0 3.1 4 0 0 4 4 4 0 KAP family P-loop domain Cytidylate_kin PF02224.18 CCM02990.1 - 0.057 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase ATP_bind_1 PF03029.17 CCM02990.1 - 0.061 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 CCM02990.1 - 0.07 13.3 0.0 0.07 13.3 0.0 2.1 2 0 0 2 2 1 0 AAA domain ScsC_N PF18312.1 CCM02990.1 - 0.084 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain FYVE_2 PF02318.16 CCM02990.1 - 0.12 12.6 1.8 0.26 11.5 0.0 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger AAA_24 PF13479.6 CCM02990.1 - 0.15 11.8 0.0 0.46 10.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CCM02990.1 - 0.17 12.3 0.0 0.17 12.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain DUF2263 PF10021.9 CCM02992.1 - 2.9e-40 138.0 0.0 4.1e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) tRNA-synt_2 PF00152.20 CCM02995.1 - 6.3e-81 271.9 0.0 9.5e-81 271.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCM02995.1 - 2.4e-12 46.7 0.0 1.4e-11 44.2 0.1 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain DUF4539 PF15072.6 CCM02995.1 - 0.039 14.0 0.0 0.49 10.5 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4539) LRR_6 PF13516.6 CCM02996.1 - 2.7 8.3 6.7 1.1e+02 3.3 0.0 4.6 4 0 0 4 4 4 0 Leucine Rich repeat ATXN-1_C PF12547.8 CCM02999.1 - 2.2 8.7 5.3 1.5 9.3 0.2 3.1 3 0 0 3 3 3 0 Capicua transcriptional repressor modulator Evr1_Alr PF04777.13 CCM03000.1 - 7.4e-27 93.7 0.5 9.6e-27 93.4 0.5 1.1 1 0 0 1 1 1 1 Erv1 / Alr family DPBB_1 PF03330.18 CCM03001.1 - 0.0055 17.0 0.1 0.0073 16.6 0.1 1.4 1 1 0 1 1 1 1 Lytic transglycolase Cpn60_TCP1 PF00118.24 CCM03002.1 - 2.1e-146 488.4 0.7 2.4e-146 488.2 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nitro_FeMo-Co PF02579.17 CCM03002.1 - 0.012 15.9 0.1 0.05 13.9 0.0 2.0 1 1 1 2 2 2 0 Dinitrogenase iron-molybdenum cofactor EAL PF00563.20 CCM03002.1 - 0.034 13.6 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 EAL domain LRR_9 PF14580.6 CCM03003.1 - 0.007 15.9 0.0 0.037 13.5 0.0 2.1 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 CCM03003.1 - 0.92 10.0 6.2 3.9 8.0 0.2 4.4 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Hce2 PF14856.6 CCM03004.1 - 0.004 17.4 0.1 0.007 16.6 0.1 1.5 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor NAD_binding_5 PF07994.12 CCM03005.1 - 5.9e-141 469.5 0.0 6.9e-141 469.3 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 CCM03005.1 - 8.9e-44 148.2 0.0 1.6e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase GGDEF_2 PF17853.1 CCM03005.1 - 0.088 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 GGDEF-like domain NIF PF03031.18 CCM03006.1 - 8e-36 123.2 0.0 1.3e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Bromodomain PF00439.25 CCM03007.1 - 9.8e-13 48.0 0.1 9.2e-08 32.1 0.1 2.4 2 0 0 2 2 2 2 Bromodomain DUF3583 PF12126.8 CCM03010.1 - 0.14 11.6 2.1 0.2 11.1 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) zf-C2H2 PF00096.26 CCM03011.1 - 2.7e-06 27.5 4.4 0.021 15.3 0.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM03011.1 - 3.7e-05 24.2 3.8 0.092 13.6 0.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger OrsD PF12013.8 CCM03011.1 - 0.007 16.8 0.6 4.5 7.8 0.1 2.4 2 0 0 2 2 2 2 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_8 PF15909.5 CCM03011.1 - 0.038 14.3 0.3 0.073 13.4 0.3 1.4 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 CCM03011.1 - 0.046 14.2 3.9 0.046 14.2 3.9 2.6 3 0 0 3 3 3 0 Zinc-finger double domain PyrI_C PF02748.15 CCM03011.1 - 0.14 12.1 0.3 1.1 9.2 0.1 2.2 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-H2C2_5 PF13909.6 CCM03011.1 - 1.9 8.3 11.7 3 7.7 0.5 3.3 2 2 0 2 2 2 0 C2H2-type zinc-finger domain RhoGAP PF00620.27 CCM03013.1 - 6.1e-38 130.0 0.0 1.2e-37 129.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain RasGEF PF00617.19 CCM03013.1 - 2e-13 50.9 2.7 3.7e-10 40.3 0.0 3.8 3 0 0 3 3 3 2 RasGEF domain PH PF00169.29 CCM03013.1 - 8e-09 36.0 0.0 0.00013 22.4 0.0 2.6 2 0 0 2 2 2 2 PH domain RasGEF_N PF00618.20 CCM03013.1 - 3.3e-06 27.3 0.0 2.3e-05 24.6 0.0 2.6 1 1 0 1 1 1 1 RasGEF N-terminal motif PH_9 PF15410.6 CCM03013.1 - 8.2e-06 26.2 0.1 0.00027 21.3 0.1 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain DUF668 PF05003.12 CCM03013.1 - 0.15 12.5 0.4 0.51 10.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF668) KR PF08659.10 CCM03014.1 - 0.2 11.5 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 KR domain Abhydrolase_1 PF00561.20 CCM03015.1 - 6.8e-27 94.7 0.3 9.2e-27 94.3 0.3 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 CCM03015.1 - 3.3e-22 77.8 0.1 6.2e-22 76.9 0.1 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 CCM03015.1 - 8.8e-07 28.4 0.0 4.4e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 CCM03015.1 - 0.053 13.1 0.3 0.16 11.6 0.3 1.7 1 1 0 1 1 1 0 Putative esterase FSH1 PF03959.13 CCM03015.1 - 0.065 12.9 0.0 0.52 9.9 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Aldedh PF00171.22 CCM03017.1 - 1.4e-08 33.7 0.1 1.5e-08 33.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family adh_short PF00106.25 CCM03019.1 - 7.9e-25 87.5 0.0 2.7e-21 75.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM03019.1 - 4.6e-14 52.6 0.0 1.5e-13 50.8 0.0 1.7 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM03019.1 - 1.3e-08 34.9 0.1 2.4e-08 34.1 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM03019.1 - 9.3e-05 22.0 0.0 0.00021 20.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM03019.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Caleosin PF05042.13 CCM03021.1 - 9e-73 243.8 0.1 1.2e-72 243.4 0.1 1.1 1 0 0 1 1 1 1 Caleosin related protein TMEM213 PF15192.6 CCM03021.1 - 0.12 12.4 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 TMEM213 family LRR_6 PF13516.6 CCM03022.1 - 6.1e-06 25.9 8.4 2.4 8.4 0.1 6.6 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 CCM03022.1 - 0.0077 16.6 6.3 2 8.9 0.0 5.0 5 1 0 5 5 5 1 Leucine Rich repeats (2 copies) Glyco_hydro_3_C PF01915.22 CCM03024.1 - 9.8e-60 202.0 0.0 1.5e-59 201.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCM03024.1 - 4.4e-41 141.3 0.0 1.1e-40 140.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCM03024.1 - 3.6e-22 78.3 0.0 9.1e-22 77.0 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 CCM03024.1 - 1.3e-12 47.8 0.0 2.6e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Pkinase PF00069.25 CCM03025.1 - 4.2e-39 134.5 0.0 5.7e-17 61.9 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03025.1 - 2.4e-12 46.7 0.9 0.0012 18.2 0.1 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase PrmA PF06325.13 CCM03025.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Pox_ser-thr_kin PF05445.11 CCM03025.1 - 0.33 9.9 0.0 0.49 9.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Aldo_ket_red PF00248.21 CCM03026.1 - 2.4e-71 240.4 0.0 2.7e-71 240.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pro-kuma_activ PF09286.11 CCM03028.1 - 3.1e-29 102.1 0.0 6.3e-29 101.1 0.0 1.5 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Pro-kuma_activ PF09286.11 CCM03029.1 - 4.1e-38 130.9 0.0 6.7e-38 130.2 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM03029.1 - 3.5e-08 33.1 1.9 3.5e-08 33.1 1.9 1.6 2 0 0 2 2 2 1 Subtilase family Pro-kuma_activ PF09286.11 CCM03030.1 - 9.7e-37 126.4 0.0 2.3e-36 125.2 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM03030.1 - 1.6e-06 27.6 3.9 1.6e-06 27.6 3.9 1.7 2 0 0 2 2 2 1 Subtilase family DUF1801 PF08818.11 CCM03031.1 - 5.5e-05 23.6 0.0 9.5 6.8 0.0 6.1 6 1 0 6 6 6 1 Domain of unknown function (DU1801) DUF2623 PF11115.8 CCM03031.1 - 0.00024 21.1 0.0 32 4.7 0.0 5.8 4 2 2 6 6 6 0 Protein of unknown function (DUF2623) Terminase_6C PF17289.2 CCM03031.1 - 0.00067 19.8 0.0 33 4.6 0.0 4.6 4 2 0 4 4 4 0 Terminase RNaseH-like domain GFO_IDH_MocA_C PF02894.17 CCM03031.1 - 0.0044 17.0 1.4 7.7 6.6 0.1 3.9 4 0 0 4 4 4 2 Oxidoreductase family, C-terminal alpha/beta domain DUF2799 PF10973.8 CCM03031.1 - 0.014 15.8 2.5 60 4.2 0.0 5.0 5 0 0 5 5 5 0 Protein of unknown function (DUF2799) F-actin_cap_A PF01267.17 CCM03031.1 - 0.1 12.0 0.0 29 4.0 0.0 3.6 3 1 1 4 4 4 0 F-actin capping protein alpha subunit CopC PF04234.12 CCM03032.1 - 2.2e-06 28.6 1.9 71 4.5 0.1 7.2 7 1 0 7 7 7 0 CopC domain Filo_VP24 PF06389.11 CCM03032.1 - 4.8e-06 26.3 0.4 67 2.9 0.0 6.7 5 2 2 7 7 7 0 Filovirus membrane-associated protein VP24 DUF1780 PF08682.10 CCM03032.1 - 0.018 14.7 0.0 28 4.3 0.0 4.1 4 1 1 5 5 5 0 Putative endonuclease, protein of unknown function (DUF1780) DUF3040 PF11239.8 CCM03032.1 - 0.047 14.0 4.7 1.4e+02 2.8 0.0 5.6 6 0 0 6 6 6 0 Protein of unknown function (DUF3040) Hypoth_Ymh PF09509.10 CCM03032.1 - 0.1 12.5 0.1 2.1e+02 1.8 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (Hypoth_ymh) UIM PF02809.20 CCM03032.1 - 4.2 7.5 5.1 2.5e+02 2.0 0.0 4.6 2 2 2 4 4 4 0 Ubiquitin interaction motif FMO-like PF00743.19 CCM03033.1 - 1.8e-12 46.5 0.0 5.6e-12 44.8 0.0 1.6 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CCM03033.1 - 5.8e-11 42.5 0.3 1.9e-10 40.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CCM03033.1 - 2e-09 37.1 0.1 7.8e-09 35.2 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM03033.1 - 2.1e-08 33.7 0.2 5.8e-08 32.3 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCM03033.1 - 5e-07 29.3 0.0 7.3e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM03033.1 - 0.012 15.3 1.1 0.019 14.5 0.2 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CCM03033.1 - 0.02 14.9 0.1 0.11 12.5 0.0 2.1 2 1 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCM03033.1 - 0.036 13.1 2.2 0.063 12.4 1.5 1.7 1 1 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CCM03033.1 - 0.071 13.7 0.2 3.8 8.1 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SET PF00856.28 CCM03034.1 - 0.00062 20.2 0.0 0.0016 18.9 0.0 1.7 2 0 0 2 2 2 1 SET domain zf-ISL3 PF14690.6 CCM03034.1 - 0.11 13.2 2.3 0.22 12.2 2.3 1.5 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Pro-kuma_activ PF09286.11 CCM03035.1 - 1.3e-34 119.6 0.1 4.2e-34 117.9 0.0 1.9 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM03035.1 - 1.4e-05 24.6 3.3 3.7e-05 23.1 3.3 1.7 1 0 0 1 1 1 1 Subtilase family Pro-kuma_activ PF09286.11 CCM03036.1 - 3.1e-22 79.4 0.0 1.3e-20 74.2 0.0 2.5 2 1 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM03036.1 - 6.7e-06 25.6 2.7 1.2e-05 24.7 2.7 1.4 1 0 0 1 1 1 1 Subtilase family SET PF00856.28 CCM03037.1 - 1.4e-06 28.9 0.0 4.4e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 SET domain F-box-like PF12937.7 CCM03038.1 - 0.0049 16.7 0.6 0.03 14.2 0.6 2.5 1 1 0 1 1 1 1 F-box-like DUF4032 PF13224.6 CCM03039.1 - 0.028 14.3 0.3 5.5 6.9 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4032) HAT_KAT11 PF08214.11 CCM03040.1 - 3.6e-40 138.3 0.0 4.7e-40 137.9 0.0 1.0 1 0 0 1 1 1 1 Histone acetylation protein Cullin PF00888.22 CCM03041.1 - 3.7e-189 630.3 15.5 5.3e-189 629.8 15.5 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCM03041.1 - 1.5e-27 95.4 1.9 5.5e-27 93.6 1.9 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain Rrf2 PF02082.20 CCM03041.1 - 0.0019 18.5 0.3 0.014 15.7 0.1 2.6 3 0 0 3 3 3 1 Transcriptional regulator MarR_2 PF12802.7 CCM03041.1 - 0.0054 16.6 0.0 0.11 12.4 0.0 2.7 2 0 0 2 2 2 1 MarR family Phage_rep_O PF04492.13 CCM03041.1 - 0.053 14.1 0.6 0.25 12.0 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage replication protein O ORC6 PF05460.13 CCM03041.1 - 0.057 12.7 4.8 0.3 10.3 0.1 2.4 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) MarR PF01047.22 CCM03041.1 - 0.13 12.2 0.4 11 6.1 0.1 2.9 2 0 0 2 2 2 0 MarR family Penicillinase_R PF03965.16 CCM03041.1 - 7.8 6.9 8.3 8.9 6.7 0.3 3.8 4 0 0 4 4 4 0 Penicillinase repressor Ubie_methyltran PF01209.18 CCM03042.1 - 7.5e-75 251.2 0.0 9.9e-75 250.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CCM03042.1 - 7.6e-14 52.2 0.0 2.3e-13 50.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM03042.1 - 3e-12 47.0 0.0 6.2e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM03042.1 - 9.6e-11 41.7 0.0 1.9e-10 40.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM03042.1 - 7.6e-10 39.4 0.0 1.8e-09 38.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM03042.1 - 1.9e-08 34.3 0.0 2.7e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CCM03042.1 - 0.094 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Fcf2 PF08698.11 CCM03043.1 - 1.8e-28 98.8 0.0 7.9e-28 96.7 0.0 2.0 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing AF-4 PF05110.13 CCM03043.1 - 0.033 12.3 16.0 0.05 11.7 16.0 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CTNNBL PF08216.11 CCM03043.1 - 0.24 11.6 0.8 0.56 10.4 0.1 1.9 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Cwf_Cwc_15 PF04889.12 CCM03043.1 - 0.42 10.3 12.0 0.32 10.7 8.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 CCM03043.1 - 3.4 5.7 10.4 4.7 5.2 10.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi adh_short PF00106.25 CCM03044.1 - 1.5e-37 129.0 0.3 1.9e-37 128.7 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM03044.1 - 1.6e-31 109.7 0.3 2.8e-31 108.9 0.3 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM03044.1 - 9.7e-14 51.7 0.3 1.8e-13 50.8 0.3 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCM03044.1 - 0.00019 20.7 0.0 0.00025 20.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCM03044.1 - 0.0028 17.1 0.1 0.0042 16.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CCM03044.1 - 0.0039 16.5 0.5 0.0098 15.2 0.1 2.0 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.8 CCM03044.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PROCN PF08083.11 CCM03045.1 - 9.2e-232 768.9 10.6 1.6e-231 768.2 9.1 1.9 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 CCM03045.1 - 2.9e-127 423.0 0.5 7.5e-127 421.6 0.4 1.7 2 0 0 2 2 2 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 CCM03045.1 - 1.1e-87 291.9 2.3 1.1e-87 291.9 2.3 2.4 3 0 0 3 3 3 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 CCM03045.1 - 4.7e-85 283.1 2.3 4.7e-85 283.1 2.3 2.8 3 0 0 3 3 3 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 CCM03045.1 - 1.1e-72 242.4 0.0 2.1e-72 241.5 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 CCM03045.1 - 9.5e-47 157.3 0.4 2.1e-46 156.2 0.4 1.6 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 CCM03045.1 - 5.1e-40 136.2 0.0 1.1e-39 135.1 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 CCM03045.1 - 0.03 14.3 0.0 0.068 13.1 0.0 1.6 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Corona_5a PF06336.11 CCM03045.1 - 0.13 12.3 0.5 0.51 10.4 0.5 2.1 1 0 0 1 1 1 0 Coronavirus 5a protein MBOAT_2 PF13813.6 CCM03048.1 - 9.2e-20 70.7 1.4 2.2e-19 69.5 1.4 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF2981 PF11200.8 CCM03048.1 - 2.4 7.8 3.5 3.6 7.2 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) OCD_Mu_crystall PF02423.15 CCM03049.1 - 1.5e-28 99.6 0.5 2.4e-27 95.7 0.5 2.4 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 CCM03049.1 - 0.021 14.9 0.1 0.19 11.8 0.1 2.2 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Cuticle_1 PF08140.11 CCM03050.1 - 0.76 9.9 3.9 24 5.1 0.0 3.2 3 0 0 3 3 3 0 Crustacean cuticle protein repeat MBOAT_2 PF13813.6 CCM03052.1 - 9.6e-13 48.2 7.0 4.1e-10 39.8 0.6 2.7 2 0 0 2 2 2 2 Membrane bound O-acyl transferase family MFS_1 PF07690.16 CCM03053.1 - 2.9e-29 102.1 48.9 6.6e-21 74.6 21.4 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM03053.1 - 1.9e-05 23.7 12.9 1.9e-05 23.7 12.9 3.7 4 2 0 4 4 4 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM03054.1 - 1.1e-26 93.6 51.7 3.3e-20 72.3 26.2 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily TPR_14 PF13428.6 CCM03055.1 - 3.1e-07 30.7 16.3 0.032 15.0 0.3 6.6 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM03055.1 - 9.3e-07 28.6 5.6 0.1 12.9 0.0 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM03055.1 - 2e-06 27.4 1.7 0.01 15.6 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM03055.1 - 2.5e-05 24.1 15.5 0.0033 17.4 0.0 6.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCM03055.1 - 0.0006 20.3 3.0 4.5 7.8 0.0 5.3 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCM03055.1 - 0.051 14.2 0.6 0.051 14.2 0.6 5.0 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 CCM03055.1 - 0.063 13.0 6.1 3.7 7.3 0.0 4.5 3 1 1 4 4 4 0 TPR repeat TPR_7 PF13176.6 CCM03055.1 - 0.083 13.0 0.3 1.7e+02 2.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 CCM03055.1 - 0.4 10.9 2.1 8.2 6.7 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat PRIMA1 PF16101.5 CCM03055.1 - 0.47 10.5 5.7 1.3 9.1 5.7 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 CCM03055.1 - 0.88 9.0 9.8 0.093 12.2 3.4 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal TPR_12 PF13424.6 CCM03055.1 - 1.1 9.5 11.4 2.4 8.5 0.1 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat SE PF08491.10 CCM03056.1 - 4.1e-92 308.1 0.0 5.3e-92 307.8 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase DAO PF01266.24 CCM03056.1 - 1.2e-09 38.3 0.1 0.00056 19.6 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCM03056.1 - 2.4e-09 36.9 0.4 5.8e-08 32.4 0.4 2.3 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 CCM03056.1 - 0.00056 18.9 0.3 0.26 10.1 0.1 2.4 3 0 0 3 3 3 2 Tryptophan halogenase FAD_binding_2 PF00890.24 CCM03056.1 - 0.002 17.3 0.3 0.23 10.5 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CCM03056.1 - 0.0026 16.9 0.1 0.011 14.9 0.1 1.9 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CCM03056.1 - 0.0032 16.7 0.2 0.039 13.2 0.0 2.4 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM03056.1 - 0.0032 16.7 0.0 0.015 14.5 0.0 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCM03056.1 - 0.0083 16.3 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCM03056.1 - 0.03 14.3 0.2 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CCM03056.1 - 0.065 13.5 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GMC_oxred_N PF00732.19 CCM03056.1 - 0.16 11.3 0.3 11 5.3 0.1 2.2 2 0 0 2 2 2 0 GMC oxidoreductase Chitin_synth_2 PF03142.15 CCM03060.1 - 5.7e-237 787.5 0.3 8.2e-237 787.0 0.3 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 CCM03060.1 - 1.6e-139 466.2 0.0 3.1e-138 462.0 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) DEK_C PF08766.11 CCM03060.1 - 1.1e-16 60.5 0.8 6.2e-16 58.1 1.6 1.9 2 0 0 2 2 2 1 DEK C terminal domain Cyt-b5 PF00173.28 CCM03060.1 - 9.8e-11 41.7 0.1 3.1e-07 30.5 0.0 2.8 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_tranf_2_3 PF13641.6 CCM03060.1 - 1.8e-09 37.9 0.0 4.8e-08 33.2 0.0 2.5 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CCM03060.1 - 6.7e-09 35.9 4.3 6.7e-09 35.9 4.3 2.1 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CCM03060.1 - 0.0016 18.3 0.0 0.6 9.9 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 AAA_29 PF13555.6 CCM03060.1 - 0.075 12.8 0.0 0.22 11.3 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CCM03060.1 - 0.12 12.7 0.1 0.49 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain TEX13 PF15186.6 CCM03062.1 - 0.14 11.9 2.0 0.22 11.2 2.0 1.3 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family Herpes_UL25 PF01499.16 CCM03062.1 - 0.51 8.8 2.9 1.2 7.6 2.9 1.6 1 1 0 1 1 1 0 Herpesvirus UL25 family Pkinase PF00069.25 CCM03064.1 - 3.2e-39 134.9 0.0 3.9e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03064.1 - 9.3e-15 54.6 0.0 1.1e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCM03064.1 - 9.9e-05 21.8 0.2 0.00021 20.7 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCM03064.1 - 0.003 16.9 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCM03064.1 - 0.0051 16.8 0.7 0.011 15.6 0.6 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM03064.1 - 0.029 13.1 0.0 0.048 12.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase STAG PF08514.11 CCM03065.1 - 7.9e-38 128.9 0.5 9.4e-37 125.4 0.2 2.8 1 1 1 2 2 2 1 STAG domain HEAT_2 PF13646.6 CCM03065.1 - 9.8e-06 25.9 1.9 0.0028 18.0 2.2 3.7 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 CCM03065.1 - 0.00022 21.2 2.2 35 5.0 0.0 6.4 6 0 0 6 6 6 1 HEAT repeat DUF4200 PF13863.6 CCM03065.1 - 1.9 8.9 7.2 0.38 11.2 3.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) ANAPC3 PF12895.7 CCM03067.1 - 5.3e-10 39.4 7.3 1.7e-05 25.0 1.0 1.5 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 CCM03067.1 - 6.7e-09 35.2 5.2 0.00018 21.4 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM03067.1 - 1.6e-07 31.7 6.2 4e-06 27.2 2.3 1.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM03067.1 - 3.9e-07 30.4 1.1 0.01 16.6 0.4 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCM03067.1 - 5.3e-06 26.1 0.9 0.045 13.8 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCM03067.1 - 0.00079 19.7 1.6 0.0026 18.0 1.2 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCM03067.1 - 0.0011 19.0 5.1 0.011 15.9 1.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CCM03067.1 - 0.0012 19.3 1.3 2.3 9.0 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM03067.1 - 0.0015 19.2 1.1 0.034 14.8 0.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM03067.1 - 0.0018 18.0 5.6 0.0071 16.1 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_20 PF14561.6 CCM03067.1 - 0.013 15.8 2.2 0.019 15.2 2.2 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 CCM03067.1 - 0.013 15.8 2.4 0.16 12.4 0.7 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 CCM03067.1 - 0.015 15.4 0.2 0.021 15.0 0.2 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat PPR PF01535.20 CCM03067.1 - 0.016 15.4 1.8 0.21 11.9 0.1 2.7 2 1 1 3 3 3 0 PPR repeat DUF4407 PF14362.6 CCM03067.1 - 0.15 11.4 4.8 0.22 10.8 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Metal_resist PF13801.6 CCM03067.1 - 0.16 12.1 2.0 0.28 11.4 1.7 1.4 1 1 0 1 1 1 0 Heavy-metal resistance Stealth_CR2 PF11380.8 CCM03068.1 - 1.2e-16 60.9 0.0 3.6e-14 52.8 0.0 2.7 3 0 0 3 3 3 2 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 CCM03068.1 - 5.7e-14 51.7 0.1 1.4e-13 50.5 0.1 1.7 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 CCM03068.1 - 0.00011 21.9 0.1 0.00021 21.0 0.1 1.5 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Telomerase_RBD PF12009.8 CCM03069.1 - 1.4e-40 138.5 0.3 4.4e-40 136.9 0.3 1.9 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 CCM03069.1 - 9.7e-13 48.1 0.1 3.3e-08 33.3 0.1 3.4 4 0 0 4 4 4 2 Reverse transcriptase (RNA-dependent DNA polymerase) RF-1 PF00472.20 CCM03072.1 - 0.0039 17.1 0.2 0.0048 16.8 0.2 1.1 1 0 0 1 1 1 1 RF-1 domain GSHPx PF00255.19 CCM03073.1 - 1.2e-43 147.1 0.6 1.5e-43 146.8 0.6 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 CCM03073.1 - 3.8e-05 23.6 0.1 0.00011 22.1 0.1 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCM03073.1 - 0.0049 16.6 0.0 0.011 15.5 0.0 1.6 1 1 0 1 1 1 1 Redoxin DUF4174 PF13778.6 CCM03073.1 - 0.0056 17.1 0.0 0.01 16.3 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4174) Metallophos PF00149.28 CCM03075.1 - 3e-12 47.5 0.0 5.4e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 CCM03075.1 - 0.0069 14.7 1.0 0.025 12.9 0.0 2.0 2 0 0 2 2 2 1 Firmicute fructose-1,6-bisphosphatase SWIRM-assoc_1 PF16495.5 CCM03076.1 - 0.16 11.9 1.9 0.36 10.8 1.9 1.6 1 0 0 1 1 1 0 SWIRM-associated region 1 SWIRM-assoc_1 PF16495.5 CCM03077.1 - 0.023 14.6 9.5 0.68 9.9 3.1 2.7 1 1 1 2 2 2 0 SWIRM-associated region 1 ARGLU PF15346.6 CCM03077.1 - 4.9 7.0 10.3 0.24 11.2 4.8 1.6 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 DUF3461 PF11944.8 CCM03078.1 - 0.093 12.9 1.1 0.18 12.0 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) Sugar_tr PF00083.24 CCM03079.1 - 6.7e-50 170.3 20.2 9.4e-50 169.8 20.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM03079.1 - 3.4e-19 69.0 27.1 3.4e-19 69.0 27.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM03080.1 - 2.9e-49 168.2 22.8 4e-49 167.7 22.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM03080.1 - 1.3e-18 67.1 27.5 2e-18 66.5 27.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily RRM_1 PF00076.22 CCM03082.1 - 2.2e-15 56.2 0.0 5.4e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.17 CCM03084.1 - 1.1e-30 103.3 1.8 4.1e-07 29.6 0.0 9.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_1 PF00515.28 CCM03084.1 - 3.5e-26 89.9 0.4 3.1e-08 33.1 0.0 8.1 9 0 0 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM03084.1 - 4.8e-25 87.6 0.6 6.9e-11 42.2 0.0 5.6 4 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CCM03084.1 - 1.1e-21 75.2 0.5 9.8e-08 31.6 0.0 6.5 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 CCM03084.1 - 5.3e-18 65.1 7.7 3.3e-11 43.3 0.2 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCM03084.1 - 4.5e-16 59.2 4.5 6e-07 30.0 0.0 5.2 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCM03084.1 - 4.1e-15 56.0 0.9 0.0081 16.6 0.1 6.2 6 1 0 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM03084.1 - 2.6e-14 52.6 0.5 4.7e-07 29.4 0.0 6.2 6 1 1 7 7 7 3 TPR repeat TPR_7 PF13176.6 CCM03084.1 - 9.2e-13 47.3 3.6 0.013 15.5 0.0 7.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 CCM03084.1 - 1.4e-11 43.9 0.7 0.053 13.9 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM03084.1 - 2.4e-11 43.4 8.5 0.00087 19.9 0.0 7.6 4 2 4 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCM03084.1 - 2.7e-10 40.2 14.5 4.6e-05 23.8 0.0 7.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCM03084.1 - 4.9e-10 39.0 3.7 0.0065 16.3 0.0 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 CCM03084.1 - 2.3e-07 30.8 6.5 1.7 9.5 0.1 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CCM03084.1 - 2.5e-07 30.4 0.2 0.00043 19.8 0.2 3.1 2 1 1 3 3 3 2 MalT-like TPR region TPR_9 PF13371.6 CCM03084.1 - 1.9e-05 24.7 0.9 0.39 10.9 0.0 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat ELYS PF13934.6 CCM03084.1 - 0.0011 19.0 0.1 0.0026 17.8 0.1 1.6 1 0 0 1 1 1 1 Nuclear pore complex assembly BTAD PF03704.17 CCM03084.1 - 0.0038 17.7 0.3 0.62 10.5 0.0 3.4 2 1 0 2 2 2 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 CCM03084.1 - 0.0039 17.2 1.9 0.63 10.1 0.1 3.9 3 1 1 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_3 PF07720.12 CCM03084.1 - 0.0087 16.0 3.4 31 4.7 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR PF01535.20 CCM03084.1 - 0.046 14.0 0.2 14 6.2 0.0 4.0 4 0 0 4 4 3 0 PPR repeat Maf1 PF09174.10 CCM03085.1 - 2.4e-40 138.5 0.2 2.5e-33 115.7 0.0 2.2 2 0 0 2 2 2 2 Maf1 regulator SCP2 PF02036.17 CCM03086.1 - 3.5e-24 85.2 1.8 4.4e-24 84.9 1.8 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 CCM03086.1 - 0.00048 20.4 0.7 0.00072 19.8 0.7 1.4 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal Dynamin_N PF00350.23 CCM03087.1 - 1.7e-42 145.3 0.0 4.8e-42 143.9 0.0 1.8 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCM03087.1 - 1.4e-10 40.9 0.0 4.5e-10 39.2 0.0 1.8 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 CCM03087.1 - 2.7e-05 24.2 0.0 6.7e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RecG_N PF17190.4 CCM03087.1 - 0.04 14.6 0.5 0.19 12.4 0.2 2.3 2 0 0 2 2 2 0 RecG N-terminal helical domain AAA_21 PF13304.6 CCM03087.1 - 0.042 13.7 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SBDS_C PF09377.10 CCM03087.1 - 0.047 13.7 0.1 0.18 11.8 0.0 2.1 2 0 0 2 2 2 0 SBDS protein C-terminal domain AAA_15 PF13175.6 CCM03087.1 - 0.063 13.0 0.4 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain RTP PF02334.16 CCM03087.1 - 0.13 12.9 0.1 0.3 11.7 0.1 1.5 1 0 0 1 1 1 0 Replication terminator protein DHDPS PF00701.22 CCM03088.1 - 2.1e-40 138.3 0.0 2.5e-40 138.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PEP_mutase PF13714.6 CCM03088.1 - 0.00087 18.8 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Med22 PF06179.12 CCM03089.1 - 6.7e-18 64.8 3.5 8.8e-18 64.5 3.5 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex ICL PF00463.21 CCM03089.1 - 0.073 11.5 0.0 0.085 11.3 0.0 1.1 1 0 0 1 1 1 0 Isocitrate lyase family Rad51 PF08423.11 CCM03090.1 - 3.6e-15 55.9 0.0 5.8e-14 52.0 0.0 2.5 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 CCM03090.1 - 3.6e-07 29.8 0.0 5.3e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 CCM03090.1 - 5.3e-05 22.9 0.0 0.00015 21.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 CCM03090.1 - 0.00016 21.3 0.0 0.00029 20.4 0.0 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 CCM03090.1 - 0.0019 17.6 0.0 0.0069 15.8 0.0 1.9 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain NB-ARC PF00931.22 CCM03090.1 - 0.077 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 CCM03090.1 - 0.095 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 CCM03090.1 - 0.13 12.6 0.2 0.5 10.7 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain Serinc PF03348.15 CCM03091.1 - 1.8e-158 528.0 12.7 2.1e-158 527.8 12.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) AAA_11 PF13086.6 CCM03092.1 - 1.7e-24 87.0 0.0 8e-12 45.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CCM03092.1 - 2.1e-14 53.7 0.0 4.4e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM03092.1 - 1.3e-13 51.5 0.0 4.4e-13 49.8 0.0 1.9 2 0 0 2 2 1 1 AAA domain Helicase_RecD PF05127.14 CCM03092.1 - 0.00021 21.2 0.1 0.00095 19.1 0.1 2.0 1 1 0 1 1 1 1 Helicase AAA_16 PF13191.6 CCM03092.1 - 0.00051 20.5 0.0 0.0019 18.6 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCM03092.1 - 0.00086 19.6 0.1 0.0041 17.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CCM03092.1 - 0.0019 18.0 0.1 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CCM03092.1 - 0.002 18.2 0.0 0.0039 17.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCM03092.1 - 0.022 14.6 0.2 0.07 12.9 0.0 2.0 2 1 0 2 2 1 0 DEAD/DEAH box helicase DUF2075 PF09848.9 CCM03092.1 - 0.022 14.0 0.1 0.41 9.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 CCM03092.1 - 0.023 14.2 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA PF00004.29 CCM03092.1 - 0.023 15.1 0.1 0.053 14.0 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CCM03092.1 - 0.026 14.3 0.0 0.079 12.7 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.6 CCM03092.1 - 0.033 13.9 0.1 0.097 12.4 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain UvrD-helicase PF00580.21 CCM03092.1 - 0.043 13.3 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain ATPase PF06745.13 CCM03092.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 KaiC Herpes_ori_bp PF02399.15 CCM03092.1 - 0.06 11.4 0.0 0.089 10.8 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein AAA_7 PF12775.7 CCM03092.1 - 0.071 12.6 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 CCM03092.1 - 0.13 11.4 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain Pro_isomerase PF00160.21 CCM03093.1 - 1.7e-41 142.1 0.0 2.3e-41 141.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Sld7_N PF18636.1 CCM03093.1 - 0.17 12.2 0.0 0.28 11.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain G-alpha PF00503.20 CCM03094.1 - 1.7e-119 399.2 0.0 2e-119 398.9 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCM03094.1 - 7e-13 48.4 0.1 1.2e-09 37.9 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 CCM03094.1 - 0.0072 16.5 0.0 2 8.7 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CCM03094.1 - 0.02 14.3 0.1 2.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 CCM03094.1 - 0.04 13.6 0.2 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 CCM03094.1 - 0.047 13.1 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein Ras PF00071.22 CCM03094.1 - 0.064 12.8 0.0 8 6.0 0.0 2.6 2 0 0 2 2 2 0 Ras family AAA_24 PF13479.6 CCM03094.1 - 0.083 12.6 0.1 1.6 8.4 0.0 2.6 2 1 1 3 3 3 0 AAA domain Anti-adapt_IraP PF10796.9 CCM03094.1 - 0.094 13.3 0.4 13 6.4 0.0 2.6 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein ATP_bind_1 PF03029.17 CCM03094.1 - 0.097 12.4 0.0 1.3 8.7 0.2 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein F_actin_cap_B PF01115.17 CCM03095.1 - 5.6e-108 360.1 0.0 6.5e-108 359.9 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit THUMP PF02926.17 CCM03096.1 - 1.8e-11 44.3 0.2 2.6e-11 43.8 0.2 1.3 1 0 0 1 1 1 1 THUMP domain Adipokin_hormo PF06377.11 CCM03096.1 - 0.0049 17.2 0.2 3.1 8.2 0.0 3.2 2 1 0 2 2 2 2 Adipokinetic hormone HD PF01966.22 CCM03097.1 - 5.2e-05 23.5 0.3 0.00011 22.4 0.3 1.6 1 1 0 1 1 1 1 HD domain Zip PF02535.22 CCM03098.1 - 4.5e-45 154.3 13.5 4e-38 131.5 5.2 2.3 2 0 0 2 2 2 2 ZIP Zinc transporter NUDIX PF00293.28 CCM03099.1 - 5.4e-14 52.3 0.1 6.7e-14 52.0 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain HLH PF00010.26 CCM03100.1 - 1.9e-06 27.7 0.0 4.5e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4604 PF15377.6 CCM03101.1 - 2.9e-32 112.5 17.4 3.4e-32 112.3 17.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) CDC45 PF02724.14 CCM03101.1 - 4.1 5.6 9.5 4.7 5.4 9.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Asp PF00026.23 CCM03103.1 - 5.1e-72 243.0 1.4 6.1e-72 242.7 1.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM03103.1 - 4.1e-10 40.2 2.1 2e-05 24.9 0.2 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal WD40 PF00400.32 CCM03104.1 - 6.3e-07 30.0 7.3 1.7 9.6 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03104.1 - 0.0019 18.5 0.0 0.21 11.9 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SH3_9 PF14604.6 CCM03105.1 - 0.0012 18.7 0.1 0.0019 18.0 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCM03105.1 - 0.012 15.2 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 SH3 domain VSP PF03302.13 CCM03105.1 - 0.17 10.7 0.7 0.24 10.2 0.7 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF2749 PF10907.8 CCM03105.1 - 0.82 9.9 4.1 0.64 10.2 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) SIR2 PF02146.17 CCM03106.1 - 1.9e-27 96.3 0.5 7e-27 94.5 0.0 2.2 2 1 0 2 2 2 1 Sir2 family TPP_enzyme_M PF00205.22 CCM03106.1 - 0.021 14.5 0.0 6.5 6.5 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain SH3_9 PF14604.6 CCM03107.1 - 0.00043 20.1 0.0 0.00081 19.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF350 PF03994.14 CCM03108.1 - 0.41 10.8 3.0 3.5 7.9 2.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF350) tRNA-synt_2b PF00587.25 CCM03110.1 - 1.4e-33 116.4 0.0 2.6e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CCM03110.1 - 5.5e-17 61.7 0.0 1.1e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 CCM03110.1 - 1.1e-15 57.4 0.0 3.2e-15 55.9 0.0 1.9 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 CCM03110.1 - 5.5e-11 42.4 0.0 1.1e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DEP PF00610.21 CCM03110.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Croc_4 PF17691.1 CCM03111.1 - 0.05 13.6 0.1 0.071 13.2 0.1 1.1 1 0 0 1 1 1 0 Contingent replication of cDNA 4 Thiolase_N PF00108.23 CCM03113.1 - 1.9e-68 230.7 0.5 4.4e-68 229.5 0.3 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCM03113.1 - 2.9e-18 65.7 2.5 1.2e-17 63.7 2.5 2.0 1 1 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCM03113.1 - 0.0011 18.6 0.4 0.016 14.8 0.2 2.7 2 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CCM03113.1 - 0.038 13.9 0.2 0.47 10.4 0.0 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III TatD_DNase PF01026.21 CCM03114.1 - 1.1e-42 146.2 0.0 2e-42 145.4 0.0 1.4 1 1 0 1 1 1 1 TatD related DNase PucR PF07905.11 CCM03114.1 - 0.016 15.5 0.0 0.9 9.8 0.0 2.5 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family FNIP PF05725.12 CCM03114.1 - 0.2 11.9 0.3 0.36 11.0 0.3 1.4 1 0 0 1 1 1 0 FNIP Repeat SHE3 PF17078.5 CCM03115.1 - 0.0054 16.5 20.3 0.01 15.6 7.0 2.3 1 1 1 2 2 2 2 SWI5-dependent HO expression protein 3 DUF4097 PF13349.6 CCM03115.1 - 0.093 12.1 0.5 0.14 11.5 0.5 1.2 1 0 0 1 1 1 0 Putative adhesin GAS PF13851.6 CCM03115.1 - 0.21 10.9 28.9 0.11 11.8 9.2 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Filament PF00038.21 CCM03115.1 - 0.49 9.9 33.6 0.68 9.5 11.7 2.9 1 1 1 2 2 2 0 Intermediate filament protein DUF4472 PF14739.6 CCM03115.1 - 1.6 9.5 28.2 0.28 11.9 7.8 4.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) bZIP_1 PF00170.21 CCM03115.1 - 1.8 8.7 19.6 1.7 8.8 0.8 4.5 3 1 1 4 4 4 0 bZIP transcription factor Cnn_1N PF07989.11 CCM03115.1 - 3.7 7.8 20.1 0.072 13.3 3.7 3.7 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 Prominin PF05478.11 CCM03115.1 - 4.2 5.2 16.9 1.2 7.0 10.5 2.0 1 1 1 2 2 2 0 Prominin CEP63 PF17045.5 CCM03115.1 - 6.6 6.6 30.9 1 9.2 2.8 2.3 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa Zn_clus PF00172.18 CCM03116.1 - 1.8e-07 31.1 10.7 3.4e-07 30.3 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CCM03116.1 - 0.00066 18.8 0.1 0.0012 18.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain TB2_DP1_HVA22 PF03134.19 CCM03117.1 - 2.4e-24 85.1 5.6 4.8e-24 84.1 5.6 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family GtrA PF04138.14 CCM03117.1 - 0.029 14.6 1.9 0.14 12.4 0.6 2.1 2 0 0 2 2 2 0 GtrA-like protein F-box-like PF12937.7 CCM03118.1 - 2.5e-08 33.7 0.0 6.2e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 F-box-like TPR_2 PF07719.17 CCM03118.1 - 4.5e-07 29.5 0.3 0.0055 16.7 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCM03118.1 - 3.1e-05 23.6 0.2 0.038 13.8 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat F-box PF00646.33 CCM03118.1 - 0.00011 21.9 1.4 0.00027 20.7 0.0 2.5 3 0 0 3 3 3 1 F-box domain TPR_12 PF13424.6 CCM03118.1 - 0.006 16.8 0.4 9.6 6.6 0.0 3.0 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM03118.1 - 0.0061 17.3 1.8 24 6.1 0.1 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCM03118.1 - 0.013 16.2 0.7 19 6.0 0.1 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCM03118.1 - 0.11 13.0 0.4 4 8.0 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.6 CCM03118.1 - 0.15 12.2 0.0 34 4.8 0.0 3.1 2 0 0 2 2 2 0 Leucine Rich repeat TPR_10 PF13374.6 CCM03118.1 - 0.36 10.8 1.3 1.1 9.2 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Sec3_C PF09763.9 CCM03119.1 - 1e-161 539.9 1.5 1.3e-161 539.5 1.5 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Glyco_transf_21 PF13506.6 CCM03119.1 - 2.4e-25 89.0 0.5 3.6e-19 68.9 0.0 2.9 2 0 0 2 2 2 2 Glycosyl transferase family 21 Sec3-PIP2_bind PF15277.6 CCM03119.1 - 2.8e-19 69.0 0.0 6.7e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Glyco_tranf_2_3 PF13641.6 CCM03119.1 - 1.6e-13 51.1 0.0 3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CCM03119.1 - 2.7e-05 24.1 0.1 0.00015 21.6 0.1 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 CCM03119.1 - 7.9e-05 22.7 1.5 0.00016 21.7 1.5 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Vps52 PF04129.12 CCM03119.1 - 0.001 17.9 0.9 0.0058 15.4 0.3 2.0 2 0 0 2 2 2 1 Vps52 / Sac2 family Rab5-bind PF09311.11 CCM03119.1 - 0.19 11.1 6.7 0.41 10.0 6.7 1.4 1 0 0 1 1 1 0 Rabaptin-like protein DUF4279 PF14106.6 CCM03119.1 - 0.33 11.2 1.0 0.82 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) RdRP PF05183.12 CCM03119.1 - 0.44 9.1 4.4 0.65 8.6 1.4 2.1 2 0 0 2 2 2 0 RNA dependent RNA polymerase WD40 PF00400.32 CCM03120.1 - 1.5e-13 51.0 6.6 0.023 15.6 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03120.1 - 0.00016 21.9 0.3 0.94 9.8 0.0 4.7 3 3 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Herpes_UL82_83 PF05784.11 CCM03120.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Betaherpesvirus UL82/83 protein N terminus Homeodomain PF00046.29 CCM03121.1 - 2.9e-14 52.6 0.5 2.9e-14 52.6 0.5 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CCM03121.1 - 0.033 14.1 0.0 0.089 12.7 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 CCM03122.1 - 7e-13 48.2 0.7 1.6e-12 47.0 0.7 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCM03122.1 - 0.0018 18.1 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 CCM03122.1 - 0.028 14.3 0.1 0.053 13.4 0.1 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT F-box-like PF12937.7 CCM03123.1 - 5.1e-08 32.7 0.3 1.2e-07 31.5 0.3 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCM03123.1 - 0.00053 20.3 0.1 41 4.8 0.0 5.1 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) PB1 PF00564.24 CCM03124.1 - 1.1e-05 25.3 0.0 2.3e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 PB1 domain Aldo_ket_red PF00248.21 CCM03125.1 - 1.5e-42 145.8 0.0 1.9e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ApbA_C PF08546.11 CCM03126.1 - 3.2e-32 111.4 0.1 6e-32 110.5 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CCM03126.1 - 5.8e-23 81.2 0.1 4.4e-22 78.4 0.1 2.2 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 CCM03126.1 - 0.07 13.4 0.2 0.29 11.4 0.1 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain MFS_1 PF07690.16 CCM03127.1 - 6.3e-39 133.9 49.1 2.7e-38 131.8 49.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM03127.1 - 1.2e-15 57.4 43.6 1.6e-13 50.3 13.0 3.1 2 1 1 3 3 3 3 Sugar (and other) transporter OATP PF03137.20 CCM03127.1 - 3.2 5.9 15.2 0.049 11.9 2.3 2.4 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family YccV-like PF08755.11 CCM03128.1 - 2.7e-16 59.9 0.0 6.3e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.6 CCM03128.1 - 6.9e-10 38.7 0.0 1.4e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 CCM03128.1 - 8.7e-06 25.5 0.6 3.5e-05 23.6 0.6 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM03128.1 - 0.00071 19.4 0.0 0.0022 17.8 0.0 2.0 1 0 0 1 1 1 1 F-box domain O-FucT PF10250.9 CCM03129.1 - 3.6e-12 46.6 0.0 5.7e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase TPT PF03151.16 CCM03130.1 - 2.5e-11 43.5 19.0 3.1e-10 39.9 19.0 1.9 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCM03130.1 - 7e-05 23.0 35.9 0.0044 17.2 17.2 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF1741 PF08427.10 CCM03132.1 - 6.1e-35 121.0 0.6 8.4e-35 120.5 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1741) GDC-P PF02347.16 CCM03133.1 - 3.7e-180 599.4 0.0 9.7e-173 574.9 0.0 2.3 2 0 0 2 2 2 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 CCM03133.1 - 8e-05 21.8 0.4 0.00043 19.3 0.1 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCM03133.1 - 0.0092 15.3 0.1 0.018 14.3 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DUF2201 PF09967.9 CCM03133.1 - 0.17 12.1 0.8 0.45 10.7 0.8 1.7 1 0 0 1 1 1 0 VWA-like domain (DUF2201) PPR_2 PF13041.6 CCM03134.1 - 2.6e-20 72.3 2.1 0.00077 19.6 0.1 7.6 5 2 4 9 9 9 5 PPR repeat family PPR PF01535.20 CCM03134.1 - 1.4e-08 34.4 6.6 0.15 12.4 0.1 8.0 8 1 0 8 8 8 2 PPR repeat PPR_1 PF12854.7 CCM03134.1 - 1.1e-06 28.2 3.1 0.42 10.4 0.2 5.6 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 CCM03134.1 - 4e-06 26.8 0.0 0.46 10.6 0.0 6.1 7 1 0 7 7 7 1 Pentatricopeptide repeat domain PPR_long PF17177.4 CCM03134.1 - 1e-05 25.0 3.4 0.25 10.7 0.8 4.7 3 1 2 5 5 5 3 Pentacotripeptide-repeat region of PRORP Gal11_ABD1 PF18535.1 CCM03134.1 - 0.26 11.4 2.6 9.2 6.4 0.0 2.8 1 1 1 2 2 2 0 Gal11 activator-binding domain (ABD1) TPR_12 PF13424.6 CCM03134.1 - 0.37 11.1 4.3 8.4 6.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat SecE PF00584.20 CCM03135.1 - 1.6e-15 56.7 0.0 1.9e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Vps51 PF08700.11 CCM03137.1 - 3.7e-12 46.2 0.2 1.7e-11 44.1 0.2 2.2 1 0 0 1 1 1 1 Vps51/Vps67 dCMP_cyt_deam_2 PF08211.12 CCM03137.1 - 0.1 12.8 0.0 0.32 11.2 0.0 1.9 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF1751 PF08551.10 CCM03138.1 - 2.8e-25 88.8 3.7 7e-25 87.5 3.7 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 CCM03138.1 - 0.0025 17.8 12.2 0.0076 16.2 12.2 1.7 1 1 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 CCM03138.1 - 0.78 9.7 6.5 2.3 8.2 6.5 1.8 1 1 0 1 1 1 0 Rhomboid family DUF1754 PF08555.10 CCM03139.1 - 6.2e-13 49.4 10.7 6.2e-13 49.4 10.7 1.4 2 0 0 2 2 2 1 Eukaryotic family of unknown function (DUF1754) DUF4191 PF13829.6 CCM03139.1 - 0.0054 16.1 0.1 0.0082 15.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4191) DUF2058 PF09831.9 CCM03139.1 - 0.28 11.3 9.1 0.75 9.9 3.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) baeRF_family12 PF18856.1 CCM03139.1 - 0.68 10.5 7.5 0.26 11.9 3.5 1.9 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 RR_TM4-6 PF06459.12 CCM03139.1 - 2 8.2 9.6 2.5 7.9 9.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_M3 PF01432.20 CCM03140.1 - 7e-132 440.9 0.0 8.9e-132 440.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 CCM03140.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Effector protein Homeodomain PF00046.29 CCM03141.1 - 1.2e-13 50.6 0.1 3.5e-13 49.2 0.1 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CCM03141.1 - 3.5e-09 36.4 0.2 3.5e-09 36.4 0.2 2.1 2 0 0 2 2 2 1 Homeobox KN domain Rep_Org_C PF06926.11 CCM03141.1 - 0.069 13.5 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 Putative replisome organiser protein C-terminus Homeobox_KN PF05920.11 CCM03142.1 - 1.1e-07 31.7 0.0 3.1e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Mating_C PF12737.7 CCM03142.1 - 1.5e-07 31.0 9.6 1.9e-07 30.7 8.7 1.7 1 1 0 1 1 1 1 C-terminal domain of homeodomain 1 Mating_N PF12731.7 CCM03142.1 - 0.00013 22.0 0.1 0.00029 20.8 0.1 1.6 1 0 0 1 1 1 1 Mating-type protein beta 1 Homeodomain PF00046.29 CCM03142.1 - 0.011 15.6 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 Homeodomain DUF2990 PF11693.8 CCM03142.1 - 0.49 10.6 5.0 2.1 8.6 0.4 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) DUF5127 PF17168.4 CCM03143.1 - 7.9e-80 267.9 2.4 1.8e-79 266.7 2.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CCM03143.1 - 3.4e-74 248.2 0.1 9.6e-74 246.8 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 CCM03143.1 - 2.1e-63 213.7 1.0 4.4e-63 212.7 1.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 CCM03143.1 - 4.1e-05 23.0 0.1 0.00012 21.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) FAD_binding_7 PF03441.14 CCM03144.1 - 1.7e-77 259.5 1.8 9.3e-77 257.1 0.4 2.3 3 0 0 3 3 3 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CCM03144.1 - 9.5e-40 136.3 0.0 1.7e-39 135.4 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase Usp PF00582.26 CCM03144.1 - 0.13 12.8 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 Universal stress protein family Phosducin PF02114.16 CCM03146.1 - 0.027 13.4 0.3 0.048 12.6 0.3 1.4 1 1 0 1 1 1 0 Phosducin DUF2167 PF09935.9 CCM03146.1 - 0.035 13.3 0.4 0.051 12.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) Thioredoxin PF00085.20 CCM03146.1 - 0.047 13.7 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin DUF2959 PF11172.8 CCM03146.1 - 0.06 13.5 0.9 0.08 13.1 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) Geminin PF07412.12 CCM03146.1 - 0.11 12.2 2.3 0.21 11.3 1.9 1.6 2 0 0 2 2 2 0 Geminin eRF1_1 PF03463.15 CCM03147.1 - 3e-48 163.1 0.1 4.5e-48 162.5 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 CCM03147.1 - 8.9e-23 80.9 0.0 1.7e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 CCM03147.1 - 7.9e-17 61.8 0.0 1.2e-16 61.3 0.0 1.2 1 0 0 1 1 1 1 eRF1 domain 2 OMPdecase PF00215.24 CCM03148.1 - 3.9e-72 242.5 0.0 4.5e-72 242.3 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family TruD PF01142.18 CCM03149.1 - 2.6e-51 174.7 0.1 2.1e-48 165.2 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) FoP_duplication PF13865.6 CCM03149.1 - 0.29 11.7 26.7 5.1 7.7 2.9 3.4 3 0 0 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 TruD PF01142.18 CCM03150.1 - 5.8e-06 25.4 0.0 1.3e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) MFS_1 PF07690.16 CCM03151.1 - 2.9e-31 108.7 18.4 2.9e-31 108.7 18.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM03151.1 - 1.9e-06 27.0 3.8 1.9e-06 27.0 3.8 2.1 2 2 0 2 2 2 1 Sugar (and other) transporter MFS_5 PF05631.14 CCM03151.1 - 0.00028 19.9 0.4 0.00049 19.1 0.4 1.4 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_Mycoplasma PF07672.13 CCM03151.1 - 0.08 12.2 1.2 0.14 11.4 1.2 1.3 1 0 0 1 1 1 0 Mycoplasma MFS transporter DUF1129 PF06570.11 CCM03151.1 - 0.18 11.3 0.9 0.71 9.3 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Gly_transf_sug PF04488.15 CCM03152.1 - 7.3e-22 77.8 0.2 1.2e-21 77.1 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 CCM03152.1 - 0.037 13.3 0.5 0.072 12.4 0.5 1.3 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 CCM03152.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein DUF3017 PF11222.8 CCM03152.1 - 5.6 7.3 8.3 0.4 11.0 2.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3017) PIN_4 PF13638.6 CCM03153.1 - 8.2e-23 81.1 0.8 1.3e-22 80.4 0.8 1.3 1 0 0 1 1 1 1 PIN domain CTD_bind PF04818.13 CCM03154.1 - 0.0001 23.1 0.0 0.00022 22.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.8 CCM03154.1 - 0.00047 20.6 1.4 0.006 17.0 0.1 2.9 2 1 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 Ribosomal_L6 PF00347.23 CCM03155.1 - 6.8e-29 100.4 3.4 2.5e-16 60.1 1.1 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 ICMT PF04140.14 CCM03156.1 - 1.5e-05 25.3 0.1 3.4e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF423 PF04241.15 CCM03156.1 - 0.36 11.0 6.1 0.13 12.5 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF423) GTP_EFTU PF00009.27 CCM03157.1 - 1.9e-47 161.4 0.0 2.9e-47 160.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CCM03157.1 - 1.6e-16 60.2 0.0 3.2e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CCM03157.1 - 1.5e-11 44.2 0.0 0.00014 21.8 0.0 2.5 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCM03157.1 - 1.7e-06 28.3 0.0 4.1e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CCM03157.1 - 0.003 17.4 0.0 0.0078 16.0 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CCM03157.1 - 0.0041 17.2 0.5 0.0086 16.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ADH_N PF08240.12 CCM03159.1 - 3.9e-30 103.9 0.2 6.4e-30 103.2 0.2 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM03159.1 - 2.2e-20 72.9 0.0 4e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCM03159.1 - 7e-05 22.4 1.7 0.0041 16.6 0.2 2.6 2 1 0 2 2 2 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCM03159.1 - 0.00013 23.1 0.0 0.0003 21.8 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCM03159.1 - 0.00028 20.3 0.3 0.00051 19.4 0.2 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CCM03159.1 - 0.023 14.3 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 CCM03159.1 - 0.05 12.8 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_25 PF13649.6 CCM03159.1 - 0.058 14.1 0.0 0.12 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Meth_synt_2 PF01717.18 CCM03160.1 - 2.1e-151 503.7 0.0 1.8e-147 490.8 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CCM03160.1 - 2.6e-118 395.1 0.0 2e-111 372.5 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain DUF2985 PF11204.8 CCM03162.1 - 1.7e-25 89.0 0.6 3.1e-25 88.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Sensor PF13796.6 CCM03162.1 - 0.014 15.5 0.8 0.084 12.9 0.0 2.1 2 0 0 2 2 2 0 Putative sensor Phage_holin_3_6 PF07332.11 CCM03162.1 - 0.12 12.4 1.1 1.4 9.0 0.1 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Apt1 PF10351.9 CCM03163.1 - 1.8e-83 281.0 1.6 1.8e-83 281.0 1.6 2.2 2 0 0 2 2 2 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 CCM03163.1 - 3e-49 168.2 0.0 9.8e-49 166.5 0.0 1.8 1 1 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 CCM03163.1 - 1.3e-36 126.1 0.0 2.7e-36 125.0 0.0 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 CCM03163.1 - 4.9e-24 85.0 0.0 1.2e-23 83.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 CCM03163.1 - 6.3e-17 62.2 0.3 3.4e-16 59.8 0.1 2.4 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DNA_pol_E_B PF04042.16 CCM03164.1 - 1.2e-44 152.2 0.3 2e-44 151.5 0.3 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 CCM03164.1 - 0.0048 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain UPF0183 PF03676.14 CCM03165.1 - 1.7e-59 202.1 0.0 2.3e-59 201.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) Hydrolase PF00702.26 CCM03166.1 - 4.8e-10 40.1 0.0 6e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCM03166.1 - 1.1e-07 32.2 0.0 1.5e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM03166.1 - 1e-05 25.5 0.0 2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Ribosomal_L6e PF01159.19 CCM03167.1 - 3.2e-30 104.9 0.2 1.2e-29 103.1 0.2 1.9 1 0 0 1 1 1 1 Ribosomal protein L6e 60KD_IMP PF02096.20 CCM03167.1 - 1.1e-09 38.4 0.0 8e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 60Kd inner membrane protein Ribosomal_L6e_N PF03868.15 CCM03167.1 - 3.2e-06 27.3 1.4 5e-06 26.7 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein L6, N-terminal domain ATP-synt_I PF03899.15 CCM03167.1 - 0.12 12.8 1.2 0.48 10.8 0.1 2.5 2 0 0 2 2 2 0 ATP synthase I chain adh_short PF00106.25 CCM03169.1 - 5.9e-30 104.2 0.0 7.4e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM03169.1 - 2.6e-16 59.9 0.0 3.5e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM03169.1 - 2e-05 24.6 0.4 4.2e-05 23.5 0.4 1.4 1 1 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 CCM03169.1 - 0.0031 17.5 0.1 0.0071 16.3 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 CCM03169.1 - 0.0052 16.3 0.1 0.018 14.5 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CCM03169.1 - 0.0056 16.0 0.0 0.0087 15.4 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 CCM03169.1 - 0.068 13.0 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 CCM03169.1 - 0.076 12.8 0.2 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein ApbA PF02558.16 CCM03169.1 - 0.09 12.4 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 CCM03169.1 - 0.092 13.2 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 CCM03169.1 - 0.1 13.2 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase YjeF_N PF03853.15 CCM03169.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus SOSSC PF15925.5 CCM03169.1 - 0.16 13.3 0.0 0.31 12.4 0.0 1.4 1 0 0 1 1 1 0 SOSS complex subunit C CRCB PF02537.15 CCM03170.1 - 1.6e-32 111.6 17.1 5.3e-18 65.1 5.7 2.3 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) PGG PF13962.6 CCM03170.1 - 0.23 11.3 3.3 0.11 12.3 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function SNARE_assoc PF09335.11 CCM03171.1 - 1.8e-15 57.5 4.1 1.8e-15 57.5 4.1 2.0 2 0 0 2 2 2 1 SNARE associated Golgi protein CK_II_beta PF01214.18 CCM03172.1 - 1.8e-74 249.5 0.0 2.6e-74 249.0 0.0 1.3 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Ribosomal_L36e PF01158.18 CCM03172.1 - 8.9e-38 128.4 2.8 1.4e-37 127.8 2.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L36e BTB PF00651.31 CCM03173.1 - 9.1e-07 29.1 0.0 1.5e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain WD40_4 PF16300.5 CCM03173.1 - 0.048 13.6 0.2 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Type of WD40 repeat Filament PF00038.21 CCM03174.1 - 0.0085 15.7 6.6 0.0085 15.7 6.6 5.6 1 1 2 4 4 4 1 Intermediate filament protein GAS PF13851.6 CCM03174.1 - 0.057 12.8 74.9 0.022 14.1 8.0 5.0 2 2 3 5 5 5 0 Growth-arrest specific micro-tubule binding Pox_A_type_inc PF04508.12 CCM03174.1 - 0.063 13.1 0.3 0.063 13.1 0.3 5.0 8 0 0 8 8 8 0 Viral A-type inclusion protein repeat PKcGMP_CC PF16808.5 CCM03174.1 - 0.91 9.4 26.8 0.36 10.7 0.1 6.4 7 0 0 7 7 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ApoO PF09769.9 CCM03174.1 - 1.1 9.2 11.6 4.7 7.2 0.7 4.2 4 0 0 4 4 4 0 Apolipoprotein O Mito_carr PF00153.27 CCM03175.1 - 4.7e-61 202.7 3.6 9.5e-23 80.0 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 CCM03175.1 - 1.3e-38 130.3 12.9 7.8e-06 26.5 0.2 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03175.1 - 9.7e-12 45.0 0.2 0.031 14.6 0.0 5.9 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain HET PF06985.11 CCM03175.1 - 7.4e-08 32.9 2.8 2.9e-06 27.7 0.1 2.9 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Gmad1 PF10647.9 CCM03175.1 - 1.6e-05 24.8 1.2 0.68 9.6 0.2 3.3 1 1 2 3 3 3 2 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 CCM03175.1 - 4.5e-05 23.3 1.5 5.7 7.0 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CCM03175.1 - 0.00023 20.2 0.2 20 4.0 0.0 5.3 2 2 4 6 6 6 0 WD40 region of Ge1, enhancer of mRNA-decapping protein EF-hand_1 PF00036.32 CCM03175.1 - 0.0033 16.8 1.1 0.0095 15.4 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 CCM03175.1 - 0.0038 17.0 0.1 0.014 15.2 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain Nup160 PF11715.8 CCM03175.1 - 0.0081 14.8 0.5 22 3.5 0.0 3.9 3 1 1 4 4 4 0 Nucleoporin Nup120/160 EF-hand_7 PF13499.6 CCM03175.1 - 0.0087 16.5 0.1 0.022 15.2 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair Piwi PF02171.17 CCM03176.1 - 2.3e-80 270.0 0.0 3.5e-80 269.5 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 CCM03176.1 - 2.7e-29 102.6 0.0 6.5e-29 101.3 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CCM03176.1 - 4.1e-17 61.6 0.0 1.1e-16 60.3 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoMid PF16487.5 CCM03176.1 - 4.6e-14 52.4 0.4 1e-13 51.4 0.4 1.5 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 CCM03176.1 - 4.2e-11 43.0 0.0 1.2e-10 41.6 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 CCM03176.1 - 1.3e-09 38.0 0.0 2.5e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 PAZ domain Histidinol_dh PF00815.20 CCM03177.1 - 1.1e-166 554.9 1.1 1.5e-166 554.5 1.1 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 CCM03177.1 - 1.5e-25 88.8 0.3 3.1e-25 87.8 0.3 1.6 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 CCM03177.1 - 5.9e-11 42.7 0.4 1.4e-10 41.4 0.1 1.8 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 CCM03177.1 - 0.068 13.4 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Transket_pyr PF02779.24 CCM03178.1 - 8.4e-48 162.4 0.1 1.6e-47 161.5 0.1 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CCM03178.1 - 3.4e-40 136.8 0.2 7.4e-40 135.7 0.2 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 CCM03178.1 - 6.6e-05 23.1 0.0 0.00015 22.0 0.0 1.6 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II adh_short PF00106.25 CCM03179.1 - 1.5e-44 151.8 0.0 1.8e-44 151.5 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM03179.1 - 6.7e-38 130.6 0.1 7.8e-38 130.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM03179.1 - 2.7e-13 50.2 0.9 4.3e-13 49.6 0.9 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM03179.1 - 3e-06 26.9 0.0 1e-05 25.1 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM03179.1 - 0.00012 22.0 0.2 0.00026 21.0 0.2 1.5 1 1 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 CCM03179.1 - 0.058 12.8 0.0 0.076 12.4 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) TetR_C_30 PF17939.1 CCM03179.1 - 0.13 12.5 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Amidohydro_2 PF04909.14 CCM03180.1 - 6.9e-31 108.1 0.0 9.5e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase Iso_dh PF00180.20 CCM03182.1 - 1.8e-70 237.8 0.1 1.3e-64 218.6 0.0 2.0 1 1 1 2 2 2 2 Isocitrate/isopropylmalate dehydrogenase DUF4839 PF16127.5 CCM03182.1 - 0.018 15.2 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4839) HABP4_PAI-RBP1 PF04774.15 CCM03183.1 - 0.092 13.6 0.1 0.19 12.6 0.1 1.5 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family Clat_adaptor_s PF01217.20 CCM03184.1 - 2.8e-45 153.7 1.3 3.3e-45 153.5 1.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain EloA-BP1 PF15870.5 CCM03185.1 - 2.1e-06 28.1 0.1 8e-06 26.2 0.1 1.9 1 1 0 1 1 1 1 ElonginA binding-protein 1 RNase_T PF00929.24 CCM03185.1 - 4.6e-05 24.0 0.0 0.00015 22.4 0.0 1.9 3 0 0 3 3 3 1 Exonuclease CHORD PF04968.12 CCM03185.1 - 0.77 10.5 4.4 1.9 9.2 4.4 1.7 1 1 0 1 1 1 0 CHORD TRAM_LAG1_CLN8 PF03798.16 CCM03186.1 - 2.3e-34 118.9 26.2 2.3e-34 118.9 26.2 1.9 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 CCM03186.1 - 4.5e-17 61.4 0.2 4.5e-17 61.4 0.2 2.1 2 0 0 2 2 2 1 TRAM1-like protein Peptidase_S10 PF00450.22 CCM03187.1 - 4.6e-77 260.2 5.7 1.5e-75 255.2 2.2 2.6 2 1 1 3 3 3 2 Serine carboxypeptidase DUF2894 PF11445.8 CCM03188.1 - 0.15 12.5 3.9 10 6.6 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2894) ORC6 PF05460.13 CCM03188.1 - 3.5 6.8 23.1 0.66 9.2 0.0 3.1 2 1 1 3 3 3 0 Origin recognition complex subunit 6 (ORC6) Histone PF00125.24 CCM03190.1 - 1.7e-26 93.1 1.3 4.9e-26 91.6 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 GRP PF07172.11 CCM03190.1 - 0.35 11.6 18.3 0.52 11.0 18.3 1.2 1 0 0 1 1 1 0 Glycine rich protein family TFIIA PF03153.13 CCM03191.1 - 5.9 6.8 14.0 23 4.8 14.0 2.0 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RTA1 PF04479.13 CCM03194.1 - 1.5e-19 70.4 1.2 1.9e-19 70.1 1.2 1.1 1 0 0 1 1 1 1 RTA1 like protein G-alpha PF00503.20 CCM03195.1 - 1.1e-56 192.5 0.0 9.1e-46 156.6 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Creatinase_N_2 PF16189.5 CCM03196.1 - 5.9e-43 146.8 0.0 1.2e-40 139.3 0.0 2.7 3 0 0 3 3 3 2 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CCM03196.1 - 2.2e-40 138.6 0.0 3.4e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 CCM03196.1 - 1.6e-18 66.5 0.1 4.8e-18 65.0 0.1 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CCM03196.1 - 1.2e-15 58.4 0.0 2.6e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain PX PF00787.24 CCM03198.1 - 2.4e-24 85.5 0.0 2.9e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 PX domain Trs65 PF12735.7 CCM03199.1 - 3.1e-24 86.0 0.1 1.1e-12 48.1 0.1 3.3 2 1 1 3 3 3 3 TRAPP trafficking subunit Trs65 Mito_carr PF00153.27 CCM03200.1 - 1e-27 95.9 3.2 1.2e-14 54.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein F-box-like PF12937.7 CCM03201.1 - 0.014 15.3 0.0 0.045 13.7 0.0 2.0 1 0 0 1 1 1 0 F-box-like Arrestin_C PF02752.22 CCM03202.1 - 5e-10 40.0 0.1 2.5e-06 28.0 0.4 3.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCM03202.1 - 6.4e-09 36.0 0.0 3e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 CCM03202.1 - 0.00013 21.7 0.0 0.00029 20.6 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like Pyridoxal_deC PF00282.19 CCM03203.1 - 3.9e-19 68.6 0.0 6.5e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CCM03203.1 - 2e-08 33.6 0.0 9.9e-08 31.3 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CCM03203.1 - 1.6e-06 27.7 0.5 2.5e-06 27.0 0.5 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family CUE PF02845.16 CCM03205.1 - 4.5e-07 29.4 0.0 7.8e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 CUE domain AC_N PF16214.5 CCM03205.1 - 2.3 7.3 5.3 3.1 6.8 5.3 1.1 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region ATP-synt_C PF00137.21 CCM03207.1 - 3.2e-25 88.2 31.5 4.8e-16 58.9 10.3 2.7 3 0 0 3 3 3 2 ATP synthase subunit C Oxidored_q2 PF00420.24 CCM03207.1 - 0.24 11.1 7.6 0.18 11.4 1.7 3.1 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L G0-G1_switch_2 PF15103.6 CCM03207.1 - 1.3 9.4 2.3 27 5.3 1.5 2.3 2 0 0 2 2 2 0 G0/G1 switch protein 2 Arf PF00025.21 CCM03208.1 - 5.6e-37 126.9 0.0 1.9e-36 125.2 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CCM03208.1 - 1.8e-10 40.5 0.0 6.9e-06 25.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CCM03208.1 - 7.6e-10 39.1 0.0 1.3e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCM03208.1 - 4.6e-07 29.6 0.0 6.9e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CCM03208.1 - 1.5e-05 24.5 0.0 1.7e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CCM03208.1 - 3.4e-05 23.4 0.0 6.1e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CCM03208.1 - 9.3e-05 22.5 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCM03208.1 - 0.0012 18.5 0.0 0.12 11.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CCM03208.1 - 0.0033 17.9 0.1 0.0063 17.0 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 CCM03208.1 - 0.01 16.4 0.3 0.02 15.4 0.1 1.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CCM03208.1 - 0.015 15.0 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCM03208.1 - 0.035 14.4 0.0 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 CCM03208.1 - 0.038 13.7 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase NACHT PF05729.12 CCM03208.1 - 0.04 13.8 0.1 0.2 11.6 0.1 1.9 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 CCM03208.1 - 0.069 13.1 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase SRP54 PF00448.22 CCM03208.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 CCM03208.1 - 0.088 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM03208.1 - 0.1 13.0 0.1 0.27 11.6 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 CCM03208.1 - 0.13 11.9 0.1 0.42 10.2 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Voltage_CLC PF00654.20 CCM03209.1 - 2.4e-86 290.2 34.1 2.4e-86 290.2 34.1 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CCM03209.1 - 3.3e-11 43.5 0.1 2.9e-05 24.4 0.0 2.9 2 0 0 2 2 2 2 CBS domain Pkinase PF00069.25 CCM03211.1 - 2.1e-10 40.4 0.0 1.8e-08 34.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03211.1 - 0.052 12.8 0.0 0.091 12.0 0.0 1.5 2 0 0 2 2 2 0 Protein tyrosine kinase Pox_A_type_inc PF04508.12 CCM03211.1 - 0.22 11.4 0.3 0.45 10.4 0.3 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Pkinase_Tyr PF07714.17 CCM03212.1 - 9.7e-45 152.9 0.0 1.4e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM03212.1 - 2.8e-36 125.3 0.0 6.5e-36 124.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 CCM03212.1 - 0.0002 20.8 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCM03212.1 - 0.035 14.0 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Syja_N PF02383.18 CCM03213.1 - 2.5e-57 194.6 0.0 4.3e-57 193.8 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Pan3_PK PF18101.1 CCM03214.1 - 2.6e-54 182.9 0.0 5.1e-54 182.0 0.0 1.4 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 CCM03214.1 - 3.4e-08 33.2 0.0 6.9e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03214.1 - 3.5e-05 23.2 0.0 7.1e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase NTP_transf_2 PF01909.23 CCM03214.1 - 5.9e-05 23.3 0.0 0.00014 22.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 CCM03214.1 - 0.022 15.0 0.0 0.06 13.6 0.0 1.7 1 0 0 1 1 1 0 Cid1 family poly A polymerase Polbeta PF18765.1 CCM03214.1 - 0.069 13.3 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase TFA2_Winged_2 PF18121.1 CCM03215.1 - 1.4e-21 75.9 0.1 3.8e-21 74.5 0.1 1.8 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 CCM03215.1 - 1.2e-15 57.6 0.7 7.4e-15 55.0 0.3 2.3 2 0 0 2 2 2 1 TFIIE beta subunit core domain Methyltransf_31 PF13847.6 CCM03215.1 - 0.078 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain LSM PF01423.22 CCM03216.1 - 1.2e-19 69.7 0.0 1.5e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 CCM03216.1 - 0.012 15.7 0.1 0.051 13.7 0.2 1.9 2 1 0 2 2 2 0 RimP C-terminal SH3 domain HEAT_EZ PF13513.6 CCM03217.1 - 5.5e-15 55.5 16.7 1.5e-09 38.2 0.0 8.7 10 2 1 11 11 11 2 HEAT-like repeat HEAT PF02985.22 CCM03217.1 - 1.2e-14 53.1 11.7 0.00026 21.0 0.0 11.0 12 0 0 12 12 12 3 HEAT repeat HEAT_2 PF13646.6 CCM03217.1 - 2.1e-11 44.1 8.6 0.087 13.2 0.0 7.4 4 2 1 6 6 6 3 HEAT repeats IBN_N PF03810.19 CCM03217.1 - 7.4e-11 41.8 2.1 1.4e-09 37.7 0.1 3.9 5 0 0 5 5 5 1 Importin-beta N-terminal domain Arm PF00514.23 CCM03217.1 - 1.3e-08 34.5 6.6 0.0028 17.7 0.1 5.8 6 0 0 6 6 5 2 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 CCM03217.1 - 0.00011 21.5 0.8 0.71 8.9 0.0 3.8 3 1 1 4 4 4 2 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 CCM03217.1 - 0.0022 18.0 1.4 0.33 11.0 0.0 3.6 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 DRIM PF07539.12 CCM03217.1 - 0.0023 16.3 0.5 15 3.8 0.0 4.1 3 1 1 4 4 4 2 Down-regulated in metastasis CLASP_N PF12348.8 CCM03217.1 - 0.0042 16.7 0.0 1.5 8.3 0.0 3.9 2 1 2 4 4 4 1 CLASP N terminal DUF3385 PF11865.8 CCM03217.1 - 0.0071 16.3 1.5 18 5.2 0.0 4.8 6 1 1 7 7 7 0 Domain of unknown function (DUF3385) Adaptin_N PF01602.20 CCM03217.1 - 0.092 11.3 0.3 12 4.3 0.0 3.1 2 1 0 3 3 3 0 Adaptin N terminal region Lon_C PF05362.13 CCM03218.1 - 6.8e-65 218.4 0.1 1.1e-64 217.7 0.1 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 CCM03218.1 - 4e-23 82.3 0.0 8e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 CCM03218.1 - 2.7e-11 43.7 0.0 5.7e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 CCM03218.1 - 6.4e-10 39.2 0.0 2.9e-09 37.1 0.0 2.2 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CCM03218.1 - 4.4e-07 30.2 0.0 1.3e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ChlI PF13541.6 CCM03218.1 - 1.2e-05 25.1 0.0 3.2e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 CCM03218.1 - 0.00082 19.8 0.1 0.00082 19.8 0.1 3.8 2 2 2 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 CCM03218.1 - 0.0015 18.8 1.4 0.063 13.6 0.1 3.3 3 1 0 3 3 2 1 AAA domain Viral_helicase1 PF01443.18 CCM03218.1 - 0.0015 18.3 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 CCM03218.1 - 0.007 16.5 0.0 0.021 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCM03218.1 - 0.0076 16.0 0.0 0.03 14.1 0.0 2.0 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 CCM03218.1 - 0.0095 15.8 0.0 0.025 14.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CCM03218.1 - 0.012 15.3 0.0 0.04 13.7 0.0 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CCM03218.1 - 0.037 13.2 0.0 0.079 12.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_7 PF12775.7 CCM03218.1 - 0.059 12.9 0.0 0.19 11.2 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CCM03218.1 - 0.11 13.0 0.1 0.43 11.1 0.0 2.1 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 CCM03218.1 - 0.12 12.8 0.0 0.55 10.6 0.0 2.2 2 0 0 2 2 1 0 RNA helicase ABC_tran PF00005.27 CCM03218.1 - 0.14 12.7 0.1 0.97 9.9 0.0 2.3 2 1 0 3 3 2 0 ABC transporter Use1 PF09753.9 CCM03218.1 - 0.2 11.3 4.3 0.34 10.6 3.1 1.9 2 0 0 2 2 2 0 Membrane fusion protein Use1 SR-25 PF10500.9 CCM03218.1 - 0.31 10.6 8.0 0.51 9.9 8.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_11 PF13086.6 CCM03218.1 - 0.43 10.3 3.4 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain ECH_2 PF16113.5 CCM03218.1 - 0.57 9.6 3.0 0.59 9.6 0.1 2.1 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Lin-8 PF03353.15 CCM03218.1 - 0.78 9.2 4.6 1.1 8.7 4.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist AAA_28 PF13521.6 CCM03218.1 - 0.84 9.9 3.4 6.5 7.0 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_23 PF13476.6 CCM03218.1 - 3.6 8.0 0.0 3.6 8.0 0.0 2.4 2 1 0 2 2 1 0 AAA domain Glyco_hydro_3 PF00933.21 CCM03219.1 - 8.8e-66 222.4 0.0 2.9e-65 220.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Amidohydro_3 PF07969.11 CCM03220.1 - 1.4e-78 265.5 0.9 1.7e-78 265.2 0.9 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCM03220.1 - 6.7e-09 35.5 0.2 3.9e-06 26.4 0.0 2.6 2 0 0 2 2 2 2 Amidohydrolase family DSPc PF00782.20 CCM03221.1 - 1.9e-22 79.5 0.0 1.1e-21 77.1 0.0 2.0 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 CCM03221.1 - 0.019 15.5 0.0 0.065 13.8 0.0 1.9 2 0 0 2 2 2 0 Rhodanese-like domain Y_phosphatase PF00102.27 CCM03221.1 - 0.092 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase SRAP PF02586.14 CCM03223.1 - 8.6e-64 215.1 0.0 1.2e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Bromo_TP PF07524.13 CCM03224.1 - 7.2e-08 32.3 0.1 1.4e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated eIF-5a PF01287.20 CCM03225.1 - 3.4e-27 94.3 0.2 5e-27 93.8 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 CCM03225.1 - 0.0055 16.7 0.0 0.0078 16.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain LIM PF00412.22 CCM03226.1 - 1.7e-21 76.1 21.9 1.2e-11 44.6 7.8 2.2 2 0 0 2 2 2 2 LIM domain Zn_Tnp_IS1595 PF12760.7 CCM03226.1 - 0.0044 17.0 26.4 0.038 14.0 5.9 3.8 2 2 2 4 4 4 2 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.10 CCM03226.1 - 0.018 15.1 21.9 0.64 10.2 2.3 4.3 4 0 0 4 4 4 0 Zinc ribbon domain zf_C2H2_13 PF18508.1 CCM03226.1 - 0.022 14.3 2.4 0.29 10.7 0.2 2.6 2 0 0 2 2 2 0 Zinc finger domain DUF2616 PF11077.8 CCM03226.1 - 0.037 13.7 3.4 2.1 8.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2616) Lar_restr_allev PF14354.6 CCM03226.1 - 0.62 10.5 19.8 2 8.8 4.1 3.4 2 2 1 3 3 3 0 Restriction alleviation protein Lar zinc_ribbon_2 PF13240.6 CCM03226.1 - 4 7.3 26.1 4.3 7.2 0.6 6.1 6 0 0 6 6 6 0 zinc-ribbon domain zf_UBZ PF18439.1 CCM03226.1 - 4.1 7.1 22.5 3.4 7.3 0.2 4.9 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger DUF3039 PF11238.8 CCM03226.1 - 8 6.3 10.0 9.1 6.1 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3039) PIH1 PF08190.12 CCM03227.1 - 4.4e-19 68.6 0.0 2.5e-17 62.8 0.0 2.2 2 0 0 2 2 2 2 PIH1 N-terminal domain DAHP_synth_1 PF00793.20 CCM03228.1 - 2.5e-97 325.1 0.1 3.1e-97 324.7 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family FAD-oxidase_C PF02913.19 CCM03228.1 - 0.0025 17.5 0.0 0.0039 16.9 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain SseB_C PF14581.6 CCM03228.1 - 0.1 12.7 0.1 0.71 10.0 0.0 2.2 2 0 0 2 2 2 0 SseB protein C-terminal domain zf-RanBP PF00641.18 CCM03229.1 - 0.065 12.6 4.7 0.12 11.7 4.7 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Adenylsucc_synt PF00709.21 CCM03230.1 - 1.7e-173 577.4 0.0 1.9e-173 577.2 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase VWA_2 PF13519.6 CCM03231.1 - 7.8e-24 84.4 0.1 2.2e-23 83.0 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 CCM03231.1 - 5.1e-11 41.7 16.3 0.00034 20.3 0.1 3.7 3 0 0 3 3 3 3 Ubiquitin interaction motif VWA PF00092.28 CCM03231.1 - 7.8e-08 32.8 0.1 1.2e-07 32.1 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 CCM03231.1 - 1.8e-05 24.7 0.0 4.1e-05 23.5 0.0 1.6 2 0 0 2 2 2 1 Ssl1-like Actin PF00022.19 CCM03232.1 - 1.1e-147 492.0 0.0 4.6e-147 489.9 0.0 1.7 1 1 0 1 1 1 1 Actin CRAL_TRIO PF00650.20 CCM03233.1 - 4.7e-35 120.7 0.0 6.9e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCM03233.1 - 6.8e-11 42.2 0.9 1.4e-10 41.2 0.9 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain EMG1 PF03587.14 CCM03234.1 - 2.7e-76 255.6 0.0 3.4e-76 255.3 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase UPRTase PF14681.6 CCM03235.1 - 2.6e-78 262.2 0.0 3e-78 262.0 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CCM03235.1 - 0.003 17.1 0.0 0.0041 16.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CoA_binding_2 PF13380.6 CCM03235.1 - 0.15 12.6 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 CoA binding domain Cpn60_TCP1 PF00118.24 CCM03236.1 - 6.5e-146 486.8 12.1 7.4e-146 486.6 12.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 CCM03236.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat DUF5442 PF17514.2 CCM03236.1 - 0.12 12.6 0.1 0.31 11.3 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5442) PMT PF02366.18 CCM03237.1 - 2.9e-79 266.1 15.9 2.9e-79 266.1 15.9 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CCM03237.1 - 1.2e-66 224.1 10.1 1.2e-66 224.1 10.1 2.6 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CCM03237.1 - 9.5e-41 139.7 0.1 9.5e-41 139.7 0.1 1.8 2 0 0 2 2 2 1 MIR domain PMT_2 PF13231.6 CCM03237.1 - 4.4e-05 23.7 11.1 4.4e-05 23.7 11.1 2.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF1240 PF06836.12 CCM03237.1 - 0.58 10.7 2.1 21 5.8 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1240) Cyclin_N PF00134.23 CCM03238.1 - 4.7e-11 42.5 0.7 1.5e-10 40.9 0.2 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 CCM03238.1 - 0.00017 21.9 0.1 0.00085 19.7 0.1 2.2 2 0 0 2 2 2 1 Cyclin C-terminal domain TFIIB PF00382.19 CCM03238.1 - 0.00055 19.9 1.0 0.0095 16.0 0.3 2.3 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C PF02984.19 CCM03238.1 - 0.019 15.1 4.5 0.047 13.8 0.4 2.6 2 1 0 2 2 2 0 Cyclin, C-terminal domain Ldh_1_C PF02866.18 CCM03239.1 - 1.5e-45 155.1 0.0 7.2e-45 152.9 0.0 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CCM03239.1 - 4.7e-42 143.4 0.0 6.7e-42 142.9 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCM03239.1 - 0.00072 18.6 0.0 0.001 18.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 CCM03239.1 - 0.052 13.1 0.1 0.97 9.0 0.0 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase WGG PF10273.9 CCM03240.1 - 2.5e-29 101.7 0.2 5e-29 100.8 0.2 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 DUF1896 PF08989.10 CCM03240.1 - 0.084 13.0 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1896) RRP7 PF12923.7 CCM03240.1 - 0.35 11.0 0.0 0.35 11.0 0.0 2.1 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Trypan_PARP PF05887.11 CCM03240.1 - 1.1 9.2 6.1 1.9 8.5 6.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CLP1_P PF16575.5 CCM03241.1 - 8e-36 123.6 0.0 2.5e-35 122.0 0.0 1.9 2 1 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 CCM03241.1 - 0.00038 20.5 0.7 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CCM03241.1 - 0.0025 17.7 0.3 0.0067 16.4 0.0 1.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea MeaB PF03308.16 CCM03241.1 - 0.015 14.3 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 CCM03241.1 - 0.024 14.9 0.0 0.27 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CCM03241.1 - 0.034 14.2 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 CCM03241.1 - 0.034 13.5 0.0 0.071 12.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 CCM03241.1 - 0.065 13.6 0.1 0.46 10.9 0.0 2.2 2 0 0 2 2 2 0 RNA helicase CbiA PF01656.23 CCM03241.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 CCM03241.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein ATP_bind_1 PF03029.17 CCM03241.1 - 0.19 11.5 0.0 0.45 10.3 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CobU PF02283.16 CCM03241.1 - 0.21 11.1 0.0 0.47 10.0 0.0 1.6 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase TFIIE-A_C PF11521.8 CCM03241.1 - 0.76 10.1 7.0 0.069 13.5 1.8 1.8 1 1 1 2 2 2 0 C-terminal general transcription factor TFIIE alpha p450 PF00067.22 CCM03242.1 - 2.9e-51 174.6 0.9 7e-51 173.4 0.9 1.6 1 1 0 1 1 1 1 Cytochrome P450 PAP_PilO PF06864.12 CCM03242.1 - 0.02 13.7 0.3 0.038 12.8 0.3 1.4 1 0 0 1 1 1 0 Pilin accessory protein (PilO) YdjC PF04794.12 CCM03242.1 - 0.066 13.2 0.4 0.23 11.4 0.1 1.9 2 0 0 2 2 2 0 YdjC-like protein p450 PF00067.22 CCM03243.1 - 7.6e-12 44.7 0.0 8e-12 44.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RA PF00788.23 CCM03244.1 - 8.9e-13 48.7 0.0 2.4e-10 40.9 0.0 3.3 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain Par3_HAL_N_term PF12053.8 CCM03244.1 - 0.11 12.8 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins His_Phos_1 PF00300.22 CCM03245.1 - 8.2e-17 61.5 0.2 1.1e-16 61.1 0.2 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Meth_synt_2 PF01717.18 CCM03246.1 - 6.3e-08 32.3 0.0 0.0015 17.9 0.0 3.0 3 0 0 3 3 3 3 Cobalamin-independent synthase, Catalytic domain F-box-like PF12937.7 CCM03247.1 - 2.5e-07 30.5 1.8 6.2e-07 29.2 1.8 1.7 1 0 0 1 1 1 1 F-box-like CBFD_NFYB_HMF PF00808.23 CCM03248.1 - 4.6e-16 58.9 3.2 1.1e-15 57.7 3.2 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM03248.1 - 7.3e-11 42.6 1.9 7.3e-11 42.5 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 CCM03248.1 - 0.00016 21.9 1.4 0.0022 18.3 0.0 2.3 2 0 0 2 2 2 1 CENP-S associating Centromere protein X TAF PF02969.17 CCM03248.1 - 0.17 12.1 0.4 0.3 11.3 0.3 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) TIP49 PF06068.13 CCM03249.1 - 1.8e-157 524.1 0.1 2.1e-157 523.8 0.1 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CCM03249.1 - 9.2e-19 67.3 0.0 2e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 CCM03249.1 - 3.2e-10 40.5 0.1 1.2e-06 29.0 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CCM03249.1 - 7.7e-09 35.5 0.0 4e-07 29.9 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCM03249.1 - 9.5e-07 29.2 0.1 0.042 14.1 0.2 2.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCM03249.1 - 6.8e-06 26.6 0.0 6.3e-05 23.4 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 CCM03249.1 - 1.5e-05 25.0 0.1 0.0075 16.3 0.1 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CCM03249.1 - 0.00051 20.3 0.1 0.0012 19.1 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM03249.1 - 0.0022 18.4 1.0 0.021 15.2 1.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CCM03249.1 - 0.0056 16.3 0.1 0.013 15.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CCM03249.1 - 0.022 14.5 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 CCM03249.1 - 0.022 14.5 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 CCM03249.1 - 0.023 14.8 0.0 0.064 13.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 CCM03249.1 - 0.023 14.1 0.1 0.13 11.6 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CCM03249.1 - 0.025 15.1 0.1 0.2 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCM03249.1 - 0.038 13.3 0.3 0.17 11.2 0.1 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_lid_2 PF17863.1 CCM03249.1 - 0.049 13.5 0.1 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA lid domain ResIII PF04851.15 CCM03249.1 - 0.056 13.4 0.0 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 CCM03249.1 - 0.059 12.9 0.0 0.45 10.0 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 CCM03249.1 - 0.075 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TFIID-31kDa PF02291.15 CCM03249.1 - 0.11 12.6 0.0 2.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit AAA_14 PF13173.6 CCM03249.1 - 0.12 12.4 0.0 14 5.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 CCM03249.1 - 0.15 11.4 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain DUF2075 PF09848.9 CCM03249.1 - 0.19 11.0 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) p450 PF00067.22 CCM03251.1 - 2.5e-62 211.2 0.0 2.5e-61 207.9 0.0 2.2 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM03252.1 - 1.2e-09 37.4 0.0 4e-09 35.7 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 DUF3692 PF12469.8 CCM03252.1 - 0.016 15.4 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein p450 PF00067.22 CCM03253.1 - 1.2e-44 152.9 0.0 1.3e-44 152.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cupin_1 PF00190.22 CCM03254.1 - 4.2e-43 146.5 0.2 3.3e-20 72.2 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCM03254.1 - 1.5e-27 95.1 0.8 5.1e-13 48.5 0.3 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCM03254.1 - 2.6e-10 39.8 0.1 0.00027 20.6 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCM03254.1 - 4.2e-07 30.0 0.3 4.5e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCM03254.1 - 0.00011 22.1 0.0 0.0016 18.4 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase Pirin_C PF05726.13 CCM03254.1 - 0.011 16.0 0.0 2.5 8.5 0.0 2.6 2 0 0 2 2 2 0 Pirin C-terminal cupin domain 3-HAO PF06052.12 CCM03254.1 - 0.012 15.3 0.0 0.13 11.9 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Cupin_4 PF08007.12 CCM03254.1 - 0.016 14.7 0.1 0.33 10.4 0.0 2.1 2 0 0 2 2 2 0 Cupin superfamily protein Ectoine_synth PF06339.12 CCM03254.1 - 0.035 14.3 0.0 5.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Ectoine synthase cNMP_binding PF00027.29 CCM03254.1 - 0.044 13.9 0.1 0.28 11.3 0.0 2.4 3 0 0 3 3 3 0 Cyclic nucleotide-binding domain ARD PF03079.14 CCM03254.1 - 0.055 13.6 0.0 0.55 10.4 0.0 2.4 3 0 0 3 3 3 0 ARD/ARD' family Cupin_8 PF13621.6 CCM03254.1 - 0.11 12.2 0.0 0.34 10.6 0.0 1.8 1 1 0 2 2 2 0 Cupin-like domain Cupin_1 PF00190.22 CCM03257.1 - 1.8e-43 147.7 0.1 5.9e-21 74.6 0.1 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCM03257.1 - 1.3e-30 104.9 0.6 4.6e-15 55.1 0.2 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCM03257.1 - 7.5e-12 44.8 0.2 0.00011 21.8 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCM03257.1 - 8.7e-08 32.2 0.2 6.6e-06 26.1 0.0 2.3 2 0 0 2 2 2 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCM03257.1 - 4.7e-06 26.6 0.0 6.9e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase ARD PF03079.14 CCM03257.1 - 0.0072 16.5 0.1 1.1 9.5 0.0 2.6 3 0 0 3 3 3 1 ARD/ARD' family 3-HAO PF06052.12 CCM03257.1 - 0.015 15.0 0.0 0.095 12.3 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase DUF1971 PF09313.11 CCM03257.1 - 0.017 15.2 0.1 3.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1971) Cupin_4 PF08007.12 CCM03257.1 - 0.02 14.3 0.1 0.19 11.2 0.1 2.0 2 0 0 2 2 2 0 Cupin superfamily protein Pirin_C PF05726.13 CCM03257.1 - 0.029 14.7 0.0 5.7 7.3 0.0 2.4 2 0 0 2 2 2 0 Pirin C-terminal cupin domain Ectoine_synth PF06339.12 CCM03257.1 - 0.035 14.3 0.0 6.3 7.0 0.0 2.2 2 0 0 2 2 2 0 Ectoine synthase Cupin_8 PF13621.6 CCM03257.1 - 0.096 12.4 0.0 0.36 10.5 0.0 1.9 1 1 0 2 2 2 0 Cupin-like domain cNMP_binding PF00027.29 CCM03257.1 - 0.13 12.3 0.1 1.3 9.2 0.0 2.5 3 0 0 3 3 3 0 Cyclic nucleotide-binding domain Terpene_synth_C PF03936.16 CCM03258.1 - 0.0014 18.0 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain SPOB_ab PF14682.6 CCM03258.1 - 0.0068 16.5 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Sporulation initiation phospho-transferase B, C-terminal Alpha-L-AF_C PF06964.12 CCM03261.1 - 3.8e-27 95.5 0.1 6.1e-27 94.8 0.1 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Sugar_tr PF00083.24 CCM03262.1 - 1.8e-100 336.9 21.8 2.1e-100 336.7 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM03262.1 - 2.5e-27 95.7 45.0 1.1e-20 73.9 19.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 CCM03262.1 - 0.0063 15.5 1.1 0.0063 15.5 1.1 2.1 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM DUF2838 PF10998.8 CCM03262.1 - 0.032 14.4 1.3 0.15 12.3 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) TRI12 PF06609.13 CCM03262.1 - 0.11 10.9 8.0 0.014 13.8 2.2 2.0 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DEAD PF00270.29 CCM03263.1 - 1.4e-38 132.4 0.0 3.2e-36 124.7 0.0 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM03263.1 - 1.9e-25 89.3 0.0 3.7e-24 85.2 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM03263.1 - 0.00029 20.9 0.0 0.00099 19.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCM03263.1 - 0.098 12.9 0.3 5.9 7.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain DUF726 PF05277.12 CCM03264.1 - 0.00011 21.3 0.0 0.00012 21.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Vsr PF03852.15 CCM03264.1 - 0.2 11.5 1.1 18 5.3 0.1 2.2 2 0 0 2 2 2 0 DNA mismatch endonuclease Vsr DUF155 PF02582.14 CCM03266.1 - 7.2e-46 156.5 0.0 1.1e-45 155.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Pkinase PF00069.25 CCM03267.1 - 5.8e-64 216.0 0.0 6.8e-64 215.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03267.1 - 1.1e-27 97.0 0.0 1.7e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM03267.1 - 4.5e-06 26.2 0.0 6.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCM03267.1 - 0.00025 20.5 0.0 0.00043 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM03267.1 - 0.00052 19.7 0.0 0.00089 18.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CCM03267.1 - 0.0022 18.0 0.2 1.2 9.0 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCM03267.1 - 0.015 14.3 0.2 0.026 13.5 0.2 1.4 1 1 0 1 1 1 0 Haspin like kinase domain NTF2 PF02136.20 CCM03268.1 - 4.5e-29 101.4 0.1 7e-29 100.8 0.1 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 CCM03268.1 - 3.6e-06 26.7 0.0 5.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rad52_Rad22 PF04098.15 CCM03269.1 - 2e-57 193.4 0.0 2.9e-57 192.9 0.0 1.3 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein NDUFA12 PF05071.16 CCM03270.1 - 7.7e-11 42.7 1.2 2.7e-10 40.9 0.0 2.1 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 WW PF00397.26 CCM03271.1 - 0.0006 19.9 0.4 0.028 14.5 0.0 2.9 2 0 0 2 2 2 1 WW domain DUF3864 PF12980.7 CCM03272.1 - 0.2 12.0 3.7 0.9 9.9 3.7 2.0 1 1 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3864) WW PF00397.26 CCM03273.1 - 0.00099 19.1 0.1 0.0025 17.9 0.1 1.7 1 0 0 1 1 1 1 WW domain Peptidase_C14 PF00656.22 CCM03274.1 - 1.1e-28 100.9 0.0 1.4e-28 100.5 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.22 CCM03275.1 - 7.7e-36 124.3 0.0 1.1e-35 123.9 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 CCM03275.1 - 0.0056 16.6 0.1 0.06 13.3 0.1 2.2 1 1 0 1 1 1 1 Raptor N-terminal CASPase like domain SPA PF08616.10 CCM03276.1 - 5e-33 113.4 0.0 1.1e-32 112.4 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 CCM03276.1 - 1.7e-17 64.1 3.9 2.7e-14 53.8 0.1 2.9 3 0 0 3 3 3 2 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 CCM03276.1 - 0.00055 18.7 0.0 0.016 13.9 0.0 2.8 2 1 1 3 3 3 1 Transport protein Avl9 DUF2347 PF09804.9 CCM03276.1 - 0.021 14.5 0.0 4.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2347) Coatomer_WDAD PF04053.14 CCM03278.1 - 6.3e-137 457.3 0.0 1.9e-136 455.7 0.0 1.7 2 0 0 2 2 2 1 Coatomer WD associated region COPI_C PF06957.11 CCM03278.1 - 2.3e-110 369.1 0.0 3.2e-110 368.7 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CCM03278.1 - 8.9e-44 146.6 13.5 2e-08 34.7 0.4 8.1 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03278.1 - 3.9e-11 43.1 0.3 0.011 16.0 0.1 6.0 4 1 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCM03278.1 - 0.0073 15.0 3.3 2.1 6.9 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 TPR_14 PF13428.6 CCM03278.1 - 0.2 12.6 4.0 15 6.7 0.2 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat XPG_I PF00867.18 CCM03279.1 - 3.4e-15 56.2 0.0 8.6e-15 54.9 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CCM03279.1 - 0.00027 21.3 0.0 0.00063 20.2 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain SGT1 PF07093.11 CCM03279.1 - 0.071 11.5 9.0 0.1 11.1 9.0 1.1 1 0 0 1 1 1 0 SGT1 protein 5_3_exonuc_N PF02739.16 CCM03279.1 - 0.08 12.8 0.0 14 5.5 0.0 2.8 3 0 0 3 3 3 0 5'-3' exonuclease, N-terminal resolvase-like domain SDA1 PF05285.12 CCM03279.1 - 0.26 10.7 10.7 0.36 10.2 10.7 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 CCM03279.1 - 0.35 9.0 17.3 0.48 8.6 17.3 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 CCM03279.1 - 3.1 7.0 13.6 4.8 6.4 13.6 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 CCM03279.1 - 9 4.5 13.2 14 3.9 13.2 1.2 1 0 0 1 1 1 0 CDC45-like protein SWIRM PF04433.17 CCM03280.1 - 5.5e-33 113.2 0.0 1e-31 109.1 0.0 2.4 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_1 PF16495.5 CCM03280.1 - 3.3e-20 71.8 8.9 3.3e-20 71.8 8.9 2.1 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 CCM03280.1 - 2.3e-11 43.7 0.0 4.6e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCM03280.1 - 1.6e-09 37.8 0.0 3.5e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 CCM03280.1 - 3.8e-07 29.8 3.4 6.7e-07 29.0 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Chordopox_RPO7 PF05864.12 CCM03280.1 - 0.24 11.7 0.9 0.86 9.9 0.2 2.2 2 0 0 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) COesterase PF00135.28 CCM03281.1 - 1.7e-79 268.1 0.3 2.6e-78 264.2 0.3 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM03281.1 - 3.9e-09 36.7 0.1 1.9e-08 34.4 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM03281.1 - 9.4e-05 22.0 0.1 0.00018 21.0 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family LIM PF00412.22 CCM03282.1 - 2.5e-30 104.5 26.8 5.5e-13 48.9 4.4 4.2 4 0 0 4 4 4 3 LIM domain DUF2321 PF10083.9 CCM03282.1 - 3.3 7.3 12.2 3.3 7.3 1.7 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) PPR_2 PF13041.6 CCM03283.1 - 1.9e-15 56.7 0.3 1.7e-05 24.9 0.2 4.5 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 CCM03283.1 - 2.3e-10 40.0 2.9 0.00012 22.0 0.3 5.1 5 0 0 5 5 5 2 PPR repeat PPR_1 PF12854.7 CCM03283.1 - 6.3e-10 38.6 1.0 0.0045 16.7 0.2 4.0 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 CCM03283.1 - 1.7e-08 34.4 0.0 0.0019 18.2 0.0 3.3 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 CCM03283.1 - 0.0016 17.8 0.3 0.51 9.7 0.0 2.8 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP SecD_SecF PF02355.16 CCM03284.1 - 0.084 12.3 0.4 0.11 11.8 0.2 1.3 1 1 0 1 1 1 0 Protein export membrane protein Pkinase PF00069.25 CCM03286.1 - 5.5e-64 216.1 0.0 9.5e-64 215.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03286.1 - 3.6e-32 111.7 0.0 6e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM03286.1 - 0.0011 19.0 0.0 0.0022 18.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Syntaxin-6_N PF09177.11 CCM03287.1 - 1.7e-26 92.6 5.1 1.7e-25 89.5 0.8 2.5 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 CCM03287.1 - 0.0072 16.3 0.2 0.016 15.2 0.2 1.6 1 0 0 1 1 1 1 SNARE domain HMMR_N PF15905.5 CCM03287.1 - 0.0077 15.7 5.2 0.018 14.5 1.1 2.1 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal Use1 PF09753.9 CCM03287.1 - 0.025 14.3 1.9 0.039 13.7 1.9 1.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 Laminin_I PF06008.14 CCM03287.1 - 0.031 14.0 3.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Laminin Domain I Spc7 PF08317.11 CCM03287.1 - 0.076 11.9 5.0 0.14 11.0 0.6 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein XhlA PF10779.9 CCM03287.1 - 0.085 13.1 1.2 3.5 7.9 0.1 2.6 2 1 0 2 2 2 0 Haemolysin XhlA Phage_GP20 PF06810.11 CCM03287.1 - 0.086 12.7 0.9 0.96 9.2 0.0 2.4 2 1 0 2 2 2 0 Phage minor structural protein GP20 EzrA PF06160.12 CCM03287.1 - 0.18 10.0 1.4 4.2 5.4 0.1 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF948 PF06103.11 CCM03287.1 - 0.2 11.9 1.9 2.7 8.3 0.1 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Bacillus_HBL PF05791.11 CCM03287.1 - 0.22 11.3 1.1 0.66 9.8 0.1 2.1 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF4618 PF15397.6 CCM03287.1 - 0.25 10.7 6.0 9 5.6 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) Laminin_II PF06009.12 CCM03287.1 - 0.28 11.2 1.8 17 5.4 0.5 2.4 2 1 0 2 2 2 0 Laminin Domain II HisKA_3 PF07730.13 CCM03287.1 - 0.52 10.9 0.1 0.52 10.9 0.1 2.9 3 1 0 3 3 3 0 Histidine kinase Fzo_mitofusin PF04799.13 CCM03287.1 - 0.67 9.5 3.0 17 5.0 0.5 2.6 2 1 0 2 2 2 0 fzo-like conserved region TPR_MLP1_2 PF07926.12 CCM03287.1 - 1 9.4 9.3 2.9 8.0 3.1 3.0 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein GTA_holin_3TM PF11351.8 CCM03287.1 - 1.1 9.8 5.0 2.6 8.6 0.5 2.6 2 1 0 2 2 2 0 Holin of 3TMs, for gene-transfer release SlyX PF04102.12 CCM03287.1 - 1.5 9.5 6.6 3.7 8.2 0.4 3.3 3 2 0 3 3 3 0 SlyX DUF3450 PF11932.8 CCM03287.1 - 3.1 7.0 10.4 0.78 9.0 0.2 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) Lebercilin PF15619.6 CCM03287.1 - 3.9 7.1 6.8 2.5 7.7 1.4 2.2 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease HIP1_clath_bdg PF16515.5 CCM03287.1 - 6.7 7.4 13.0 2 9.1 1.1 3.5 2 2 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4140 PF13600.6 CCM03287.1 - 9.8 6.7 8.5 0.35 11.3 0.7 2.4 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) zf-C3HC4_3 PF13920.6 CCM03288.1 - 4e-11 42.6 6.1 2.6e-09 36.8 1.5 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM03288.1 - 0.00022 21.0 2.1 0.00063 19.6 0.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCM03288.1 - 0.00087 19.6 5.4 0.0042 17.4 1.9 2.5 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 CCM03288.1 - 0.00094 19.0 4.5 0.00094 19.0 4.5 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCM03288.1 - 0.01 15.8 2.6 0.11 12.4 0.6 2.3 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCM03288.1 - 0.47 10.5 6.1 6.7 6.8 0.9 2.6 2 0 0 2 2 2 0 RING-type zinc-finger Ribosomal_L27A PF00828.19 CCM03289.1 - 6.3e-23 81.9 0.0 9.4e-23 81.3 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RNA_pol_L_2 PF13656.6 CCM03290.1 - 4.2e-27 93.7 0.1 5.7e-27 93.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CCM03290.1 - 2.4e-12 46.1 0.0 3.6e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Rio2_N PF09202.11 CCM03290.1 - 0.021 15.1 0.0 0.044 14.0 0.0 1.4 2 0 0 2 2 2 0 Rio2, N-terminal Zn_clus PF00172.18 CCM03291.1 - 0.51 10.5 9.8 0.82 9.8 3.3 2.3 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0220 PF05255.11 CCM03294.1 - 2e-56 190.1 0.0 2.5e-56 189.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) adh_short_C2 PF13561.6 CCM03295.1 - 7.5e-52 176.2 0.1 9.3e-52 175.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM03295.1 - 1.1e-48 165.3 0.3 1.4e-48 165.0 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM03295.1 - 7.7e-07 29.2 0.3 1e-06 28.8 0.3 1.1 1 0 0 1 1 1 1 KR domain MM_CoA_mutase PF01642.22 CCM03295.1 - 0.00032 19.4 0.2 0.00041 19.0 0.2 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase THF_DHG_CYH_C PF02882.19 CCM03295.1 - 0.003 16.9 0.0 0.0069 15.7 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DFP PF04127.15 CCM03295.1 - 0.0053 16.6 0.2 0.019 14.8 0.1 1.9 2 0 0 2 2 2 1 DNA / pantothenate metabolism flavoprotein DUF1776 PF08643.10 CCM03295.1 - 0.051 12.9 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCM03295.1 - 0.076 12.5 0.1 0.095 12.1 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Aldo_ket_red PF00248.21 CCM03296.1 - 1.3e-37 129.6 0.0 2.8e-36 125.2 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family Oxidored_FMN PF00724.20 CCM03296.1 - 4.1e-30 105.2 0.0 1.1e-28 100.5 0.0 2.2 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family LRR_4 PF12799.7 CCM03297.1 - 0.0068 16.8 0.8 2 9.0 0.0 3.8 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) DUF3809 PF12723.7 CCM03297.1 - 0.086 13.1 0.2 12 6.2 0.0 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3809) PCMT PF01135.19 CCM03298.1 - 4.5e-64 216.1 0.0 5.5e-64 215.8 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CCM03298.1 - 2e-06 27.7 0.0 2.5e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM03298.1 - 4.3e-05 23.4 0.0 6.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CCM03298.1 - 0.00012 22.1 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM03298.1 - 0.00035 21.2 0.0 0.0007 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM03298.1 - 0.00035 21.2 0.0 0.00085 20.0 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CCM03298.1 - 0.015 16.3 0.1 0.079 14.0 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain MetW PF07021.12 CCM03298.1 - 0.018 14.6 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW EF-hand_1 PF00036.32 CCM03298.1 - 0.021 14.4 0.0 0.07 12.7 0.0 2.0 2 0 0 2 2 2 0 EF hand PrmA PF06325.13 CCM03298.1 - 0.065 12.6 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CCM03298.1 - 0.096 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain EF-hand_6 PF13405.6 CCM03298.1 - 0.1 12.6 0.0 1.4 9.0 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain PPTA PF01239.22 CCM03299.1 - 3e-41 138.0 18.0 2.6e-10 39.7 0.6 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF2490 PF10677.9 CCM03299.1 - 0.012 15.5 1.1 0.45 10.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2490) FoP_duplication PF13865.6 CCM03300.1 - 1.6e-08 35.0 0.9 1.8e-08 34.8 0.9 1.1 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 CCM03301.1 - 4.2e-10 39.3 0.0 6.8e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCM03301.1 - 0.0027 17.5 0.0 0.0044 16.8 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif Bclt PF15318.6 CCM03301.1 - 0.065 13.1 0.6 0.09 12.6 0.6 1.2 1 0 0 1 1 1 0 Putative Bcl-2 like protein of testis Ribosomal_60s PF00428.19 CCM03301.1 - 0.092 13.3 1.8 0.18 12.4 1.8 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein RNA_pol_3_Rpc31 PF11705.8 CCM03302.1 - 3.4e-27 96.2 4.8 5.2e-27 95.6 4.8 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 SR-25 PF10500.9 CCM03303.1 - 2.2 7.8 18.1 3.3 7.3 18.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PNRC PF15365.6 CCM03304.1 - 1.7e-06 27.6 5.7 1.7e-06 27.6 5.7 4.8 4 0 0 4 4 4 1 Proline-rich nuclear receptor coactivator motif RGS12_usC PF16612.5 CCM03306.1 - 0.0095 16.4 0.6 0.012 16.1 0.6 1.2 1 0 0 1 1 1 1 C-terminal unstructured region of RGS12 DUF3311 PF11755.8 CCM03306.1 - 0.12 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3311) Pkinase_fungal PF17667.1 CCM03307.1 - 2.1e-42 145.4 0.0 6.1e-41 140.5 0.0 2.6 2 1 0 2 2 2 1 Fungal protein kinase SPT_ssu-like PF11779.8 CCM03310.1 - 4.1e-12 45.5 4.1 4.8e-12 45.3 3.3 1.5 1 1 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like DUF3951 PF13131.6 CCM03310.1 - 0.0052 17.0 1.9 0.0093 16.1 1.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3951) Inhibitor_I66 PF16850.5 CCM03311.1 - 3.5e-16 59.4 0.0 7.6e-16 58.3 0.0 1.5 1 1 0 1 1 1 1 Peptidase inhibitor I66 Golgin_A5 PF09787.9 CCM03312.1 - 0.3 10.5 17.7 0.62 9.5 17.7 1.5 1 0 0 1 1 1 0 Golgin subfamily A member 5 T6PP_N PF18572.1 CCM03312.1 - 0.72 9.7 6.5 1.8 8.4 6.5 1.7 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Macoilin PF09726.9 CCM03312.1 - 1.8 7.0 16.1 3 6.3 16.1 1.3 1 0 0 1 1 1 0 Macoilin family DUF1490 PF07371.12 CCM03312.1 - 2.7 8.2 5.4 6.2 7.0 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1490) Ribosomal_S7 PF00177.21 CCM03313.1 - 6.2e-37 126.5 1.5 7.6e-37 126.2 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Med12 PF09497.10 CCM03316.1 - 4.1e-27 94.2 0.1 1e-26 93.0 0.1 1.7 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 CCM03316.1 - 1.2e-06 27.6 0.0 4e-05 22.7 0.0 2.2 1 1 0 1 1 1 1 Eukaryotic Mediator 12 subunit domain SopA PF13981.6 CCM03316.1 - 0.04 14.3 0.0 2.8 8.4 0.0 3.3 3 0 0 3 3 3 0 SopA-like central domain NUC173 PF08161.12 CCM03316.1 - 0.065 12.9 0.1 0.66 9.6 0.0 2.2 2 0 0 2 2 2 0 NUC173 domain CPSase_sm_chain PF00988.22 CCM03318.1 - 1e-44 151.4 0.0 1.6e-44 150.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CCM03318.1 - 5.3e-37 127.4 0.0 7.7e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCM03318.1 - 4.8e-08 33.0 0.1 1.9e-06 27.8 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 CCM03318.1 - 0.0015 18.4 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family BSD PF03909.17 CCM03319.1 - 6.2e-08 32.5 0.6 1.5e-07 31.3 0.6 1.6 1 0 0 1 1 1 1 BSD domain DUF883 PF05957.13 CCM03319.1 - 0.024 15.2 0.1 1.4 9.6 0.0 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Nop14 PF04147.12 CCM03319.1 - 0.08 11.2 27.8 0.12 10.5 27.8 1.4 1 0 0 1 1 1 0 Nop14-like family Mpp10 PF04006.12 CCM03319.1 - 0.11 10.9 27.8 0.18 10.2 27.8 1.3 1 0 0 1 1 1 0 Mpp10 protein RPN2_C PF18004.1 CCM03319.1 - 0.53 10.2 10.0 1.4 8.9 10.0 1.7 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DDHD PF02862.17 CCM03319.1 - 1.7 8.8 6.5 47 4.0 0.0 3.1 2 1 0 2 2 2 0 DDHD domain SNF2_N PF00176.23 CCM03320.1 - 1.2e-48 165.6 0.2 8.6e-48 162.8 0.0 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 CCM03320.1 - 1.7e-18 66.3 0.0 4.3e-18 65.0 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain zf-PARP PF00645.18 CCM03320.1 - 1.4e-14 54.7 0.0 4.3e-14 53.1 0.0 2.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Helicase_C PF00271.31 CCM03320.1 - 4.1e-12 46.4 0.0 3.2e-06 27.5 0.0 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CCM03320.1 - 5e-08 32.7 6.2 9.8e-08 31.7 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM03320.1 - 1.5e-07 31.1 2.8 2.8e-07 30.3 2.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM03320.1 - 1.2e-06 28.4 6.6 2.6e-06 27.4 6.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CCM03320.1 - 1.4e-06 28.1 5.8 2.7e-06 27.1 5.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCM03320.1 - 2.5e-06 27.7 5.6 4.8e-06 26.8 5.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CCM03320.1 - 2.9e-06 27.1 3.2 5.5e-06 26.2 3.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCM03320.1 - 1.3e-05 25.2 6.2 3e-05 24.1 6.2 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 CCM03320.1 - 0.00055 20.2 3.8 0.0031 17.8 3.8 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 CCM03320.1 - 0.0015 18.3 2.3 0.0033 17.3 2.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 CCM03320.1 - 0.0073 16.2 5.3 0.034 14.0 5.5 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CCM03320.1 - 0.68 9.8 2.8 1.9 8.4 2.8 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain K-box PF01486.17 CCM03320.1 - 5.8 7.2 9.3 0.51 10.5 1.4 2.7 2 0 0 2 2 2 0 K-box region Metallophos PF00149.28 CCM03321.1 - 0.00025 21.6 0.1 0.00049 20.7 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DAGK_cat PF00781.24 CCM03322.1 - 2.4e-13 49.8 0.1 4.1e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain UDPGP PF01704.18 CCM03323.1 - 1.1e-195 650.1 1.0 1.4e-195 649.8 1.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PAP_central PF04928.17 CCM03323.1 - 0.1 11.6 0.1 1.4 7.8 0.0 2.2 2 0 0 2 2 2 0 Poly(A) polymerase central domain RCC1 PF00415.18 CCM03324.1 - 1.7e-17 63.8 1.5 4.8e-05 23.9 0.0 5.8 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCM03324.1 - 4.6e-11 42.2 20.3 0.00065 19.4 0.5 6.0 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 CCM03324.1 - 1.5e-05 24.8 2.7 1.6e-05 24.7 1.5 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM03324.1 - 0.00096 19.0 2.6 0.0017 18.2 2.6 1.4 1 0 0 1 1 1 1 F-box domain CHAT PF12770.7 CCM03325.1 - 1.6e-24 86.9 0.0 2.3e-12 46.9 0.0 2.3 1 1 1 2 2 2 2 CHAT domain TPR_10 PF13374.6 CCM03325.1 - 2.3e-11 43.2 2.4 0.46 10.4 0.0 8.8 9 0 0 9 9 9 4 Tetratricopeptide repeat UDPGP PF01704.18 CCM03327.1 - 4.2e-200 664.7 2.2 4.9e-200 664.5 2.2 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase PAP_central PF04928.17 CCM03327.1 - 0.12 11.4 0.1 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 Poly(A) polymerase central domain Ribosomal_S8e PF01201.22 CCM03328.1 - 1.5e-53 180.6 0.8 2e-53 180.2 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e SET PF00856.28 CCM03329.1 - 1.8e-08 35.0 0.0 4.5e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 SET domain AT_hook PF02178.19 CCM03329.1 - 3.7 7.7 25.0 0.28 11.2 0.9 3.9 3 0 0 3 3 3 0 AT hook motif Cpn60_TCP1 PF00118.24 CCM03330.1 - 4.2e-161 536.9 0.6 6.3e-161 536.3 0.6 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family APC1_C PF18122.1 CCM03331.1 - 3.3e-37 128.0 0.3 6e-37 127.2 0.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain PC_rep PF01851.22 CCM03331.1 - 1.4 9.5 20.1 4.1 8.0 0.3 5.7 6 0 0 6 6 6 0 Proteasome/cyclosome repeat Pkinase PF00069.25 CCM03332.1 - 6.2e-64 215.9 0.0 7.8e-64 215.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03332.1 - 6.4e-32 110.9 0.0 1.4e-31 109.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2397 PF09660.10 CCM03332.1 - 0.00071 18.6 1.6 0.0011 18.0 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2397) Kinase-like PF14531.6 CCM03332.1 - 0.0067 15.8 0.7 0.017 14.5 0.6 1.7 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CCM03332.1 - 0.022 13.7 0.1 0.031 13.2 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CCM03332.1 - 0.13 12.2 2.3 0.45 10.4 0.1 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L4 PF00573.22 CCM03334.1 - 2.8e-39 134.8 1.1 4.8e-39 134.0 1.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 CCM03334.1 - 3.1e-28 97.6 1.8 3.1e-28 97.6 1.8 2.2 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain F-box-like PF12937.7 CCM03335.1 - 6.8e-05 22.7 2.2 0.00016 21.5 2.2 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 CCM03335.1 - 0.0026 17.6 0.1 0.0072 16.2 0.1 1.8 1 0 0 1 1 1 1 F-box F-box PF00646.33 CCM03335.1 - 0.077 12.9 3.5 0.083 12.8 0.9 2.4 2 0 0 2 2 2 0 F-box domain WD40 PF00400.32 CCM03336.1 - 2.2e-22 78.9 15.8 0.00037 21.2 0.1 8.0 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03336.1 - 4.7e-06 26.8 0.0 0.085 13.2 0.0 3.9 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCM03336.1 - 0.0029 17.0 0.0 2.4 7.4 0.0 3.2 2 2 1 3 3 3 2 WD40-like domain DUF5046 PF16465.5 CCM03336.1 - 0.0062 16.0 0.1 0.014 14.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5046) BBS2_Mid PF14783.6 CCM03336.1 - 0.0083 16.2 0.0 6.1 6.9 0.0 4.0 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 CCM03336.1 - 0.021 13.2 0.0 0.56 8.5 0.0 2.2 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PQQ PF01011.21 CCM03336.1 - 0.047 13.6 0.0 10 6.3 0.0 3.1 2 0 0 2 2 2 0 PQQ enzyme repeat Nup160 PF11715.8 CCM03336.1 - 0.15 10.7 1.3 1.4 7.4 0.1 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 F-box-like PF12937.7 CCM03337.1 - 1.3e-06 28.2 2.2 3e-06 27.0 2.2 1.6 1 0 0 1 1 1 1 F-box-like Ten1_2 PF15490.6 CCM03338.1 - 5.7e-08 32.5 0.0 8.5e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit SKG6 PF08693.10 CCM03339.1 - 0.0022 17.4 0.5 0.0046 16.3 0.5 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 CCM03339.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF1768 PF08719.11 CCM03340.1 - 2.4e-17 63.6 0.0 3.8e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) RRM_3 PF08777.11 CCM03341.1 - 5.1e-06 26.5 0.0 2.6e-05 24.2 0.0 2.2 1 1 0 1 1 1 1 RNA binding motif RRM_1 PF00076.22 CCM03341.1 - 0.00066 19.4 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rubi_NSP_C PF12601.8 CCM03341.1 - 0.099 12.8 0.3 0.39 10.9 0.0 2.1 3 0 0 3 3 3 0 Rubivirus non-structural protein SKG6 PF08693.10 CCM03342.1 - 0.0003 20.1 0.7 0.0003 20.1 0.7 2.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Mid2 PF04478.12 CCM03342.1 - 0.00046 20.0 0.1 0.0012 18.7 0.0 1.7 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor Gram_pos_anchor PF00746.21 CCM03342.1 - 0.094 12.7 1.1 0.34 10.9 1.1 2.0 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Amnionless PF14828.6 CCM03342.1 - 0.094 11.5 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Amnionless Mito_carr PF00153.27 CCM03343.1 - 1.9e-48 162.3 3.2 6.1e-15 54.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein UQ_con PF00179.26 CCM03344.1 - 3.3e-21 75.4 0.0 5.7e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme IBR PF01485.21 CCM03344.1 - 0.001 19.2 3.2 0.0024 18.1 3.2 1.5 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain BUD22 PF09073.10 CCM03344.1 - 2.3 7.4 8.2 4.1 6.6 6.5 2.0 2 0 0 2 2 2 0 BUD22 Fungal_trans PF04082.18 CCM03345.1 - 6.8e-20 71.2 3.6 6.7e-19 68.0 0.9 2.7 2 1 0 2 2 2 1 Fungal specific transcription factor domain zf-CCHC PF00098.23 CCM03346.1 - 3.6e-05 23.6 38.4 0.00035 20.5 3.1 4.7 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_3 PF13917.6 CCM03346.1 - 0.0007 19.5 18.4 0.082 12.9 2.2 4.7 3 1 1 4 4 4 4 Zinc knuckle ABC_tran PF00005.27 CCM03347.1 - 1.1e-15 58.4 0.0 3.4e-15 56.7 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCM03347.1 - 3.3e-09 37.0 3.7 0.00024 21.0 0.6 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CCM03347.1 - 0.0013 18.4 0.0 0.003 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCM03347.1 - 0.0027 17.4 0.1 0.0058 16.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF4381 PF14316.6 CCM03347.1 - 0.0063 16.8 0.3 0.022 15.0 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) RsgA_GTPase PF03193.16 CCM03347.1 - 0.0094 15.9 0.1 0.016 15.1 0.1 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 CCM03347.1 - 0.012 15.4 0.1 0.017 14.8 0.1 1.1 1 0 0 1 1 1 0 AAA ATPase domain EphA2_TM PF14575.6 CCM03347.1 - 0.04 14.8 0.0 0.08 13.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain AAA_23 PF13476.6 CCM03347.1 - 0.044 14.3 0.1 0.071 13.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CCM03347.1 - 0.056 13.1 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SKG6 PF08693.10 CCM03347.1 - 0.061 12.7 1.7 0.13 11.7 1.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Zeta_toxin PF06414.12 CCM03347.1 - 0.1 11.9 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin PduV-EutP PF10662.9 CCM03347.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 CCM03347.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Insulin_TMD PF17870.1 CCM03347.1 - 0.18 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Phage_holin_2_4 PF16082.5 CCM03347.1 - 1.1 9.1 4.2 0.27 11.0 0.2 2.1 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like zf-C2H2 PF00096.26 CCM03348.1 - 0.0071 16.7 2.2 1.6 9.3 0.0 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type PBP1_TM PF14812.6 CCM03348.1 - 0.11 12.8 3.3 0.26 11.7 3.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 CCM03348.1 - 0.33 9.0 4.0 0.44 8.6 4.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-H2C2_2 PF13465.6 CCM03348.1 - 0.5 10.9 3.1 7 7.3 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-H2C2_5 PF13909.6 CCM03348.1 - 0.63 9.9 0.1 0.63 9.9 0.1 2.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Apt1 PF10351.9 CCM03348.1 - 0.89 8.3 4.5 1.1 8.0 4.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-C2H2_4 PF13894.6 CCM03348.1 - 2.3 9.3 8.7 20 6.3 1.7 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger Yae1_N PF09811.9 CCM03349.1 - 0.0052 16.5 4.6 0.0082 15.8 4.6 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Med2 PF11214.8 CCM03349.1 - 0.35 11.0 2.7 0.76 10.0 2.7 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 Alanine_zipper PF11839.8 CCM03349.1 - 7.8 6.9 21.5 6.6 7.2 7.5 2.4 1 1 1 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Nucleoporin2 PF04096.14 CCM03350.1 - 9.7e-46 155.6 0.0 1.4e-45 155.1 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 CCM03350.1 - 0.025 15.4 76.8 0.085 13.7 37.5 5.3 2 2 2 4 4 4 0 Nucleoporin FG repeat region Nucleoporin_FG PF13634.6 CCM03351.1 - 4.5e-12 46.7 177.9 0.00011 23.0 33.5 6.3 1 1 4 5 5 5 5 Nucleoporin FG repeat region RNA_pol_Rpb2_6 PF00562.28 CCM03352.1 - 1.6e-110 369.8 0.0 3e-110 368.9 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCM03352.1 - 1.4e-33 116.2 0.0 2.2e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 CCM03352.1 - 1.4e-27 95.6 0.0 3.1e-27 94.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 CCM03352.1 - 5.5e-22 77.5 0.0 1.9e-21 75.8 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 CCM03352.1 - 2.1e-19 69.7 0.1 1.5e-15 57.3 0.1 2.7 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 CCM03352.1 - 5.6e-13 48.9 0.0 1.7e-11 44.1 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 DUF4207 PF13904.6 CCM03354.1 - 0.0026 17.5 14.2 0.0026 17.5 14.2 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4207) zf-C2H2 PF00096.26 CCM03354.1 - 0.015 15.7 14.9 0.19 12.2 1.3 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type PIP5K PF01504.18 CCM03354.1 - 0.03 13.6 1.9 0.069 12.4 1.9 1.6 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase zf-C2H2_8 PF15909.5 CCM03354.1 - 0.072 13.4 6.0 0.26 11.6 5.6 2.1 1 1 1 2 2 2 0 C2H2-type zinc ribbon DUF2795 PF11387.8 CCM03354.1 - 0.11 12.8 0.5 0.55 10.5 0.5 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) zf-C2H2_4 PF13894.6 CCM03354.1 - 0.17 12.8 13.2 2.7 9.1 1.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4770 PF15994.5 CCM03354.1 - 1.6 8.9 12.5 6.2 7.0 12.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RPA43_OB PF17875.1 CCM03354.1 - 1.6 9.4 12.9 1.6 9.4 6.6 2.6 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I eIF-3_zeta PF05091.12 CCM03354.1 - 4.7 6.1 15.5 9.7 5.0 15.5 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Spem1 PF15670.5 CCM03354.1 - 8.2 5.9 17.7 2.9 7.4 8.7 2.6 2 0 0 2 2 2 0 Spermatid maturation protein 1 Methyltransf_23 PF13489.6 CCM03355.1 - 7.2e-15 55.2 0.0 1.1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM03355.1 - 1.8e-09 38.1 0.0 3.2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM03355.1 - 2.2e-08 34.7 0.0 4.3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM03355.1 - 5.5e-08 33.5 0.0 1.2e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM03355.1 - 4.7e-06 26.5 0.0 8.4e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CCM03355.1 - 0.0051 15.9 0.0 0.0075 15.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.6 CCM03355.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CCM03355.1 - 0.026 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain NNMT_PNMT_TEMT PF01234.17 CCM03355.1 - 0.069 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family tRNA_m1G_MT PF01746.21 CCM03356.1 - 1.1e-23 84.0 0.3 1.3e-19 70.7 0.1 2.2 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase LCD1 PF09798.9 CCM03356.1 - 0.28 9.6 1.8 0.39 9.2 1.8 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DDRGK PF09756.9 CCM03356.1 - 0.37 10.3 16.4 0.61 9.6 16.4 1.3 1 0 0 1 1 1 0 DDRGK domain NARP1 PF12569.8 CCM03356.1 - 0.51 9.2 14.7 0.78 8.6 14.7 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 CCM03356.1 - 0.54 8.5 8.2 0.94 7.7 8.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CCM03356.1 - 3.9 6.1 8.4 6.1 5.5 8.4 1.2 1 0 0 1 1 1 0 Presenilin Abhydrolase_2 PF02230.16 CCM03357.1 - 1.2e-45 155.9 0.0 3e-45 154.7 0.0 1.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 CCM03357.1 - 0.00063 19.5 0.0 0.00085 19.0 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 CCM03357.1 - 0.00064 19.0 0.0 0.2 10.9 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 CCM03357.1 - 0.00091 18.9 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 CCM03357.1 - 0.0055 16.6 0.0 0.0066 16.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CCM03357.1 - 0.0066 16.1 0.1 0.092 12.4 0.1 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM03357.1 - 0.0074 16.9 0.0 0.0088 16.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CCM03357.1 - 0.0083 15.7 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Cutinase PF01083.22 CCM03357.1 - 0.021 14.8 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 Cutinase Peptidase_S9 PF00326.21 CCM03357.1 - 0.07 12.6 0.0 1.1 8.7 0.0 2.1 1 1 1 2 2 2 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 CCM03357.1 - 0.12 12.3 0.4 0.48 10.3 0.3 1.9 1 1 0 2 2 2 0 Lipase (class 3) AXE1 PF05448.12 CCM03357.1 - 0.2 10.3 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) EVE PF01878.18 CCM03358.1 - 3e-36 124.6 0.1 5.2e-36 123.8 0.1 1.4 1 0 0 1 1 1 1 EVE domain SMK-1 PF04802.15 CCM03359.1 - 3e-80 268.6 5.9 3.2e-80 268.5 3.5 2.1 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 RRM_1 PF00076.22 CCM03360.1 - 4e-11 42.6 0.2 4.4e-08 32.8 0.0 3.9 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Band_7 PF01145.25 CCM03361.1 - 2.4e-27 96.1 2.8 4e-27 95.4 2.8 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family RGS PF00615.19 CCM03362.1 - 1.1e-05 25.7 0.0 0.00015 22.0 0.0 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain eIF2A PF08662.11 CCM03363.1 - 1.8e-40 138.9 0.2 5.8e-24 85.1 0.0 4.3 4 2 1 5 5 5 3 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 CCM03363.1 - 2.8e-07 30.2 0.0 6.8e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 CCM03363.1 - 0.0075 17.1 3.7 6.8 7.7 0.1 5.3 6 0 0 6 6 6 1 WD domain, G-beta repeat RRM_1 PF00076.22 CCM03364.1 - 2.2e-32 110.7 0.0 5e-16 58.3 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCM03364.1 - 4e-05 23.6 0.0 0.00014 21.9 0.0 1.9 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.5 CCM03364.1 - 0.0013 18.8 0.0 0.85 9.8 0.1 3.4 3 0 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CCM03364.1 - 0.003 17.5 0.0 0.0098 15.9 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif JmjC PF02373.22 CCM03365.1 - 5.7e-13 49.3 0.5 1.5e-12 47.9 0.0 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 CCM03365.1 - 0.0046 16.7 0.0 0.041 13.6 0.0 2.4 1 1 0 1 1 1 1 Cupin-like domain C1_1 PF00130.22 CCM03365.1 - 0.041 13.8 2.1 0.094 12.6 2.1 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_2 PF14445.6 CCM03365.1 - 1.6 9.0 12.9 0.24 11.6 4.2 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 2 TFIIA PF03153.13 CCM03365.1 - 3.9 7.4 11.3 6.5 6.6 11.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FYVE PF01363.21 CCM03365.1 - 5.2 7.3 15.6 0.041 14.0 5.8 2.5 3 0 0 3 3 3 0 FYVE zinc finger Response_reg PF00072.24 CCM03366.1 - 4.3e-23 81.6 0.2 4e-17 62.4 0.2 2.6 2 0 0 2 2 2 2 Response regulator receiver domain Oxidored_nitro PF00148.19 CCM03366.1 - 0.0047 15.7 0.0 0.0077 15.0 0.0 1.2 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase ARS2 PF04959.13 CCM03367.1 - 7.8e-14 52.5 1.1 7.8e-14 52.5 1.1 3.1 3 1 0 3 3 3 1 Arsenite-resistance protein 2 DUF3546 PF12066.8 CCM03367.1 - 2.4e-13 50.2 0.1 2.4e-13 50.2 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) RRM_1 PF00076.22 CCM03367.1 - 1.4e-05 24.8 0.0 0.38 10.6 0.0 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4187 PF13821.6 CCM03367.1 - 0.0015 18.3 0.9 0.0045 16.7 0.9 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) zf-C2H2_2 PF12756.7 CCM03367.1 - 0.58 10.5 2.3 4.2 7.8 0.2 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) dUTPase PF00692.19 CCM03368.1 - 8e-43 145.2 0.0 1e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 dUTPase ADH_N PF08240.12 CCM03370.1 - 5.3e-24 84.2 3.1 1.3e-23 83.0 3.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM03370.1 - 2.7e-18 66.2 0.1 5.1e-18 65.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCM03370.1 - 0.0046 16.3 0.3 0.009 15.3 0.3 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCM03370.1 - 0.015 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CLLAC PF15675.5 CCM03370.1 - 0.41 10.2 2.5 1 9.0 2.5 1.6 1 0 0 1 1 1 0 CLLAC-motif containing domain Vfa1 PF08432.10 CCM03371.1 - 1.6e-40 139.3 0.0 2e-40 139.1 0.0 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF4674 PF15719.5 CCM03371.1 - 0.28 11.2 5.8 0.37 10.8 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Rrn6 PF10214.9 CCM03371.1 - 0.36 9.3 5.3 0.42 9.0 5.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Rtf2 PF04641.12 CCM03371.1 - 0.37 10.1 7.5 0.59 9.4 7.5 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger MAP65_ASE1 PF03999.12 CCM03371.1 - 0.39 9.4 6.9 0.48 9.1 6.9 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) XRCC4 PF06632.12 CCM03371.1 - 0.53 9.1 7.2 0.68 8.7 7.2 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 FAM176 PF14851.6 CCM03371.1 - 0.79 9.4 3.1 1 9.0 3.1 1.2 1 0 0 1 1 1 0 FAM176 family ANAPC_CDC26 PF10471.9 CCM03371.1 - 0.81 10.6 7.5 0.19 12.6 2.5 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 CDC45 PF02724.14 CCM03371.1 - 1.7 6.9 5.4 2 6.6 5.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Nucleoside_tran PF01733.18 CCM03372.1 - 2.7e-40 138.6 11.0 2.7e-40 138.6 11.0 1.9 2 1 0 2 2 2 1 Nucleoside transporter Ost5 PF05251.12 CCM03372.1 - 0.07 13.4 0.7 0.07 13.4 0.7 4.3 5 0 0 5 5 5 0 Oligosaccharyltransferase subunit 5 GTP_EFTU PF00009.27 CCM03373.1 - 2.8e-44 151.0 0.0 4.7e-44 150.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 CCM03373.1 - 3e-16 59.5 3.2 2.7e-15 56.4 0.9 2.5 2 0 0 2 2 2 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 CCM03373.1 - 1.4e-11 44.7 0.0 4.3e-11 43.1 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 CCM03373.1 - 1.6e-06 28.2 0.0 0.00043 20.3 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CCM03373.1 - 0.12 12.8 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Elongation factor Tu domain 2 AAA_22 PF13401.6 CCM03373.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain SSB PF00436.25 CCM03374.1 - 8.5e-18 64.3 0.0 1.1e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family Haem_degrading PF03928.14 CCM03375.1 - 1.1e-10 41.6 0.0 2.3e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 Haem-degrading Mg_trans_NIPA PF05653.14 CCM03376.1 - 2.5e-62 210.6 7.2 4.8e-59 199.9 3.6 2.0 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CCM03376.1 - 1.5e-05 25.2 0.8 1.5e-05 25.2 0.8 3.6 3 1 0 3 3 3 1 EamA-like transporter family SLC35F PF06027.12 CCM03376.1 - 0.013 15.0 0.1 0.013 15.0 0.1 2.2 1 1 1 2 2 2 0 Solute carrier family 35 VMA21 PF09446.10 CCM03376.1 - 0.21 11.7 3.2 0.82 9.8 1.5 2.4 2 0 0 2 2 2 0 VMA21-like domain WD40 PF00400.32 CCM03377.1 - 7.3e-11 42.5 0.3 0.0046 17.8 0.0 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03377.1 - 0.00027 21.2 0.0 0.26 11.6 0.0 3.5 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TFIID-31kDa PF02291.15 CCM03378.1 - 1.2e-37 128.7 0.0 1.9e-37 128.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 CCM03378.1 - 0.0002 21.4 0.0 0.0005 20.1 0.0 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 CCM03378.1 - 0.00064 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated CENP-S PF15630.6 CCM03378.1 - 0.0007 19.9 0.0 0.0014 19.0 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein DUF2415 PF10313.9 CCM03378.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Histone PF00125.24 CCM03378.1 - 0.21 11.9 0.0 0.37 11.2 0.0 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 MBOAT PF03062.19 CCM03379.1 - 8.2e-46 156.9 5.5 8.2e-46 156.9 5.5 2.1 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF1925 PF09094.11 CCM03379.1 - 0.091 13.1 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) MARVEL PF01284.23 CCM03380.1 - 3.2e-07 30.5 20.5 4.8e-07 29.9 20.5 1.3 1 0 0 1 1 1 1 Membrane-associating domain Sugar_tr PF00083.24 CCM03381.1 - 1.1e-71 242.0 25.0 3.8e-55 187.6 5.3 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCM03381.1 - 2.7e-21 75.9 31.5 6.2e-20 71.4 22.9 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CCM03381.1 - 4e-06 25.6 1.1 4e-06 25.6 1.1 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) WD40 PF00400.32 CCM03383.1 - 7e-11 42.5 11.3 0.002 18.9 0.3 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat Carboxyl_trans PF01039.22 CCM03384.1 - 2.3e-137 458.6 0.1 2.9e-137 458.3 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CCM03384.1 - 0.00039 20.0 0.5 0.028 13.9 0.0 2.2 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) Nop PF01798.18 CCM03385.1 - 4.2e-74 248.9 0.0 6e-74 248.4 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 CCM03385.1 - 6.5e-36 123.9 3.8 1.2e-35 123.0 3.8 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain NifU_N PF01592.16 CCM03386.1 - 6.1e-54 181.6 0.0 8.2e-54 181.2 0.0 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain DUF2838 PF10998.8 CCM03387.1 - 2.4e-43 146.9 11.7 5e-43 145.9 11.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2838) Apolipoprotein PF01442.18 CCM03387.1 - 0.13 12.1 5.2 0.35 10.7 3.0 2.0 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain A_deamin PF02137.18 CCM03388.1 - 2.9e-68 230.7 0.0 3.8e-68 230.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain WD40 PF00400.32 CCM03390.1 - 2.2e-05 25.1 12.3 0.013 16.3 0.1 5.8 4 1 0 4 4 4 2 WD domain, G-beta repeat p450 PF00067.22 CCM03391.1 - 3.4e-64 217.3 0.0 4.4e-64 216.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 CCM03392.1 - 2.9e-65 220.1 0.1 3.5e-65 219.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM03392.1 - 2.8e-46 157.4 0.1 3.4e-46 157.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM03392.1 - 9e-07 29.0 0.2 1.9e-06 27.9 0.0 1.5 2 0 0 2 2 2 1 KR domain 3HCDH_N PF02737.18 CCM03392.1 - 0.0012 18.8 0.3 0.0023 17.8 0.1 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CCM03392.1 - 0.013 15.1 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 CCM03392.1 - 0.088 13.5 0.0 0.19 12.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF962 PF06127.11 CCM03393.1 - 4.9e-12 45.8 1.6 9.2e-12 44.9 1.6 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Longin PF13774.6 CCM03394.1 - 4.9e-27 93.8 0.0 7.2e-27 93.3 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 CCM03394.1 - 7.3e-05 22.5 0.0 0.00014 21.6 0.0 1.5 1 0 0 1 1 1 1 Synaptobrevin DUF4646 PF15496.6 CCM03395.1 - 3.5e-08 34.1 3.8 1.2e-05 26.0 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4646) XRN_M PF17846.1 CCM03396.1 - 1.2e-146 489.2 3.3 2.2e-108 363.1 0.2 2.7 3 0 0 3 3 3 2 Xrn1 helical domain XRN_N PF03159.18 CCM03396.1 - 4.5e-100 334.0 0.0 7.6e-100 333.3 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 CCM03396.1 - 0.00027 20.9 2.4 0.00049 20.0 2.4 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 CCM03396.1 - 0.0048 16.8 1.2 0.0092 15.9 1.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 CCM03396.1 - 0.043 13.7 1.6 0.078 12.8 1.6 1.4 1 0 0 1 1 1 0 Zinc knuckle IF-2B PF01008.17 CCM03397.1 - 1.2e-84 283.9 0.1 1.4e-84 283.6 0.1 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family MTP18 PF10558.9 CCM03398.1 - 1.5e-64 217.1 6.7 2e-63 213.4 6.7 1.9 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) tRNA-synt_2 PF00152.20 CCM03399.1 - 1.1e-83 280.9 0.0 3.3e-41 141.4 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CCM03399.1 - 7.7e-07 29.0 0.0 1.7e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain IMD PF08397.11 CCM03400.1 - 1.7e-06 27.6 1.1 2.5e-06 27.0 1.1 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain Spc7 PF08317.11 CCM03400.1 - 0.0018 17.2 0.8 0.0026 16.7 0.8 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein BAR_3 PF16746.5 CCM03400.1 - 0.007 16.1 0.8 0.012 15.4 0.8 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Phage_int_SAM_2 PF12834.7 CCM03400.1 - 0.047 14.4 0.1 0.097 13.4 0.1 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal ARD PF03079.14 CCM03400.1 - 0.047 13.9 1.0 0.075 13.2 1.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family OmpH PF03938.14 CCM03400.1 - 0.18 12.1 1.4 0.31 11.4 1.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4709 PF15821.5 CCM03400.1 - 0.25 11.6 5.8 0.51 10.6 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4709) ACPS PF01648.20 CCM03401.1 - 3.5e-14 52.9 0.0 4.6e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily PfkB PF00294.24 CCM03402.1 - 3.3e-10 39.8 0.0 4.4e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CBFD_NFYB_HMF PF00808.23 CCM03403.1 - 6.9e-20 71.1 0.7 1.2e-19 70.3 0.7 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM03403.1 - 0.00022 21.6 0.4 0.00067 20.0 0.0 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 4HB_MCP_1 PF12729.7 CCM03403.1 - 0.055 13.0 1.7 0.078 12.5 1.7 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction LSM PF01423.22 CCM03404.1 - 1.4e-21 75.9 0.0 1.6e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCM03404.1 - 0.0081 16.3 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain RRM_1 PF00076.22 CCM03405.1 - 1.3e-10 41.0 0.2 1.5e-08 34.3 0.2 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCM03405.1 - 1.1e-05 25.0 0.2 0.0033 17.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 CCM03405.1 - 0.01 15.8 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 CCM03405.1 - 0.036 14.1 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Limkain b1 DEAD PF00270.29 CCM03406.1 - 9.6e-15 54.8 0.0 2.3e-14 53.6 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM03406.1 - 0.0041 17.4 0.0 0.009 16.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain WD40 PF00400.32 CCM03407.1 - 4.8e-38 128.5 28.1 5.7e-06 27.0 0.3 10.8 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03407.1 - 1.1e-11 44.8 1.8 0.54 10.6 0.0 7.2 6 1 2 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM03407.1 - 6.7e-05 22.0 0.0 5.1 6.0 0.0 4.1 3 1 0 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ACPS PF01648.20 CCM03408.1 - 8.4e-13 48.4 0.0 9.8e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily GST_N PF02798.20 CCM03410.1 - 5.9e-12 45.8 0.0 1.1e-11 44.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM03410.1 - 1.5e-09 38.0 0.0 2.7e-09 37.1 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCM03410.1 - 1.6e-09 38.0 0.0 3.3e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM03410.1 - 2.1e-08 34.3 0.0 3.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCM03410.1 - 5.9e-06 26.4 0.0 1.3e-05 25.3 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM03410.1 - 0.023 14.7 0.0 0.054 13.5 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Octopine_DH PF02317.17 CCM03410.1 - 0.026 14.6 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain MT-A70 PF05063.14 CCM03411.1 - 2.1e-57 193.8 0.0 2.8e-57 193.4 0.0 1.2 1 0 0 1 1 1 1 MT-A70 DinI PF06183.13 CCM03411.1 - 0.011 16.1 0.0 0.03 14.7 0.0 1.7 1 0 0 1 1 1 0 DinI-like family CLZ PF16526.5 CCM03411.1 - 0.084 13.2 0.5 0.17 12.3 0.5 1.5 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels adh_short PF00106.25 CCM03412.1 - 3.5e-11 42.9 0.0 1.6e-10 40.8 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM03412.1 - 6.9e-06 25.8 0.0 1.1e-05 25.1 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM03412.1 - 0.0086 16.0 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 KR domain GMC_oxred_N PF00732.19 CCM03415.1 - 3.1e-62 210.6 0.0 4e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM03415.1 - 2.2e-31 109.3 0.0 3.7e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCM03415.1 - 0.00039 19.6 0.4 0.0007 18.8 0.4 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CCM03415.1 - 0.00064 19.4 0.3 0.0039 16.8 0.3 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCM03415.1 - 0.00073 18.9 0.0 0.0035 16.6 0.0 2.0 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 CCM03415.1 - 0.01 14.9 1.7 0.61 9.1 0.4 2.5 3 0 0 3 3 3 0 FAD binding domain NAD_binding_8 PF13450.6 CCM03415.1 - 0.011 15.9 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 CCM03415.1 - 0.1 11.4 0.1 0.16 10.8 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase AMP-binding PF00501.28 CCM03416.1 - 7.4e-29 100.6 0.0 8.9e-28 97.0 0.0 2.4 3 0 0 3 3 3 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CCM03416.1 - 4.2e-28 98.2 0.0 6.8e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CCM03416.1 - 1.7e-07 31.0 0.0 2.8e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM03416.1 - 0.00071 19.9 0.2 0.0096 16.3 0.2 2.5 1 1 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 CCM03416.1 - 0.027 14.4 0.0 0.027 14.4 0.0 2.0 2 0 0 2 2 2 0 KR domain DapB_N PF01113.20 CCM03416.1 - 0.15 12.2 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F-box-like PF12937.7 CCM03420.1 - 0.0003 20.6 0.1 0.0011 18.9 0.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.13 CCM03420.1 - 0.17 12.6 1.7 1.2 10.0 0.2 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat RTA1 PF04479.13 CCM03424.1 - 4.9e-62 209.2 3.9 6.9e-62 208.7 3.9 1.2 1 0 0 1 1 1 1 RTA1 like protein Cation_efflux PF01545.21 CCM03424.1 - 0.09 12.5 5.2 0.13 12.0 3.6 2.0 1 1 1 2 2 2 0 Cation efflux family p450 PF00067.22 CCM03425.1 - 8e-48 163.3 0.0 1.1e-47 162.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Imm8 PF15586.6 CCM03425.1 - 0.092 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 8 Methyltransf_25 PF13649.6 CCM03426.1 - 1.5e-05 25.6 0.0 0.00016 22.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM03426.1 - 0.014 15.2 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain SQS_PSY PF00494.19 CCM03427.1 - 3.3e-16 59.6 0.0 5.2e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase TGS PF02824.21 CCM03427.1 - 0.064 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 TGS domain polyprenyl_synt PF00348.17 CCM03428.1 - 7.8e-63 211.9 0.0 9.7e-63 211.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase p450 PF00067.22 CCM03429.1 - 1.3e-43 149.5 0.0 2e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 UbiA PF01040.18 CCM03430.1 - 8.2e-05 22.0 0.9 9.1e-05 21.9 0.3 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family SQS_PSY PF00494.19 CCM03431.1 - 5.6e-28 98.2 0.0 8e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase p450 PF00067.22 CCM03432.1 - 3e-22 79.0 0.0 1.9e-11 43.4 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Melibiase_C PF17801.1 CCM03432.1 - 0.064 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Alpha galactosidase C-terminal beta sandwich domain SQS_PSY PF00494.19 CCM03433.1 - 9.5e-18 64.6 0.0 1.3e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase CCM2_C PF16545.5 CCM03433.1 - 0.044 14.3 0.0 0.091 13.3 0.0 1.5 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology Sod_Fe_C PF02777.18 CCM03434.1 - 1.3e-35 121.7 0.1 2.1e-35 120.9 0.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CCM03434.1 - 1.3e-32 112.1 3.0 1.3e-32 112.1 3.0 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain UbiA PF01040.18 CCM03439.1 - 1.6e-07 30.9 13.1 8e-07 28.6 1.1 2.1 2 0 0 2 2 2 2 UbiA prenyltransferase family IncD PF17628.2 CCM03439.1 - 0.0058 16.4 1.3 0.0087 15.8 0.3 1.8 2 0 0 2 2 2 1 Inclusion membrane protein D GMC_oxred_C PF05199.13 CCM03440.1 - 2.1e-34 119.1 0.1 3.3e-34 118.5 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CCM03440.1 - 6.2e-29 101.3 0.0 8e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CCM03441.1 - 1.5e-66 224.8 0.4 2.5e-66 224.1 0.1 1.5 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM03441.1 - 9.5e-38 130.0 0.0 1.7e-37 129.1 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCM03441.1 - 4.9e-05 22.6 2.1 0.056 12.5 0.1 2.6 3 0 0 3 3 3 2 FAD binding domain Lycopene_cycl PF05834.12 CCM03441.1 - 0.00023 20.4 0.1 0.00043 19.5 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCM03441.1 - 0.00045 20.4 0.1 0.0018 18.4 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM03441.1 - 0.00052 19.4 0.0 0.003 16.8 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM03441.1 - 0.0065 16.1 3.0 0.021 14.4 0.2 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCM03441.1 - 0.11 11.7 0.1 0.3 10.3 0.1 1.7 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 CCM03441.1 - 0.2 10.4 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pil1 PF13805.6 CCM03443.1 - 6.6e-19 68.4 0.2 9.3e-19 67.9 0.2 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 IFT57 PF10498.9 CCM03443.1 - 0.045 12.7 0.7 0.073 12.0 0.7 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF3510 PF12022.8 CCM03443.1 - 0.073 13.4 0.1 0.14 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) NUP50 PF08911.11 CCM03444.1 - 0.044 14.4 1.8 0.053 14.2 0.1 2.0 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) GMC_oxred_N PF00732.19 CCM03445.1 - 1.7e-17 63.8 0.0 2.5e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM03445.1 - 0.00053 20.5 0.0 0.00087 19.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase VHS PF00790.19 CCM03446.1 - 3.2e-37 127.5 0.0 7.3e-37 126.3 0.0 1.6 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 CCM03446.1 - 4.1e-18 65.4 0.2 3.5e-17 62.5 0.0 2.5 3 0 0 3 3 3 1 GAT domain p450 PF00067.22 CCM03447.1 - 1.7e-77 261.1 0.0 3e-64 217.5 0.0 2.3 2 1 0 2 2 2 2 Cytochrome P450 vATP-synt_E PF01991.18 CCM03448.1 - 4.6e-57 192.6 13.1 5.3e-57 192.4 13.1 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit TRAPP PF04051.16 CCM03448.1 - 0.067 12.9 0.1 0.13 11.9 0.0 1.6 1 1 0 1 1 1 0 Transport protein particle (TRAPP) component DUF883 PF05957.13 CCM03448.1 - 3.4 8.3 9.8 0.39 11.3 3.6 2.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Glyco_hyd_65N_2 PF14498.6 CCM03449.1 - 1e-35 123.7 2.1 2.9e-33 115.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 65, N-terminal domain Phage_TTP_12 PF16461.5 CCM03449.1 - 0.031 14.0 0.1 0.078 12.7 0.1 1.6 1 0 0 1 1 1 0 Lambda phage tail tube protein, TTP Acetyltransf_CG PF14542.6 CCM03450.1 - 0.0017 18.4 0.0 0.22 11.7 0.0 2.9 3 0 0 3 3 3 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 CCM03450.1 - 0.0078 16.4 0.0 0.013 15.7 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Bestrophin PF01062.21 CCM03451.1 - 5.2e-29 101.6 8.8 8.3e-18 64.8 0.9 2.1 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel F-box-like PF12937.7 CCM03452.1 - 5.5e-05 23.0 0.6 5.5e-05 23.0 0.6 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM03452.1 - 0.00015 21.6 0.5 0.00015 21.6 0.5 2.3 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 CCM03452.1 - 1 9.9 5.1 14 6.2 0.8 3.8 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) bZIP_Maf PF03131.17 CCM03453.1 - 0.029 14.9 1.3 0.068 13.7 1.3 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor ATG27 PF09451.10 CCM03455.1 - 3.9e-24 85.9 0.0 4.9e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 CCM03455.1 - 0.0002 21.5 0.3 0.015 15.4 0.1 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat APG12 PF04110.13 CCM03456.1 - 8.7e-31 106.2 0.0 1.1e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 CCM03456.1 - 0.002 18.3 0.0 0.0025 18.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Methyltransf_3 PF01596.17 CCM03459.1 - 3.9e-40 137.3 0.0 4.7e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CCM03459.1 - 1.9e-16 61.0 0.0 3.3e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM03459.1 - 1.9e-08 34.3 0.0 4e-08 33.2 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM03459.1 - 8.3e-07 29.6 0.0 2.9e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CCM03459.1 - 1e-05 25.4 0.0 1.3e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 CCM03459.1 - 2.3e-05 24.9 0.0 0.00012 22.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CCM03459.1 - 0.0039 16.9 0.0 0.0059 16.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 CMAS PF02353.20 CCM03459.1 - 0.08 12.2 0.0 0.17 11.2 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 CCM03459.1 - 0.087 12.7 0.0 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_15 PF09445.10 CCM03459.1 - 0.17 11.4 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase ADH_N PF08240.12 CCM03460.1 - 4.3e-17 62.0 0.9 6.9e-17 61.3 0.9 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM03460.1 - 8.8e-16 58.1 0.1 1.8e-15 57.1 0.1 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_2 PF03446.15 CCM03460.1 - 0.051 13.7 0.1 0.076 13.2 0.1 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Tgi2PP PF18250.1 CCM03460.1 - 0.059 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Effector immunity protein Tgi2PP APG12 PF04110.13 CCM03461.1 - 7.2e-30 103.2 0.0 8.5e-30 103.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 CCM03461.1 - 0.0032 17.6 0.0 0.0034 17.5 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like GST_N_3 PF13417.6 CCM03462.1 - 1.4e-05 25.4 0.1 3.1e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM03462.1 - 0.00017 21.9 0.2 0.00029 21.1 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CCM03462.1 - 0.054 13.9 0.1 0.23 11.8 0.1 2.0 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCM03462.1 - 0.069 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TAL_FSA PF00923.19 CCM03463.1 - 1.3e-95 320.0 0.0 1.5e-95 319.8 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Peptidase_M14 PF00246.24 CCM03464.1 - 3.2e-63 214.2 0.1 4.1e-63 213.9 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Tmemb_170 PF10190.9 CCM03465.1 - 1.5e-06 28.6 0.2 0.0038 17.6 0.3 2.2 2 0 0 2 2 2 2 Putative transmembrane protein 170 RAMP4 PF06624.12 CCM03465.1 - 0.27 11.3 1.1 0.89 9.7 1.1 1.8 1 1 0 1 1 1 0 Ribosome associated membrane protein RAMP4 ArAE_2_N PF10337.9 CCM03466.1 - 1.2e-54 186.1 2.4 3.9e-54 184.5 2.4 1.9 1 1 0 1 1 1 1 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 CCM03466.1 - 8.1e-32 110.9 0.0 1.8e-28 99.9 0.0 2.3 2 0 0 2 2 2 2 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 CCM03466.1 - 8.1e-09 35.7 18.0 8.1e-09 35.7 18.0 4.6 4 0 0 4 4 4 1 Fusaric acid resistance protein-like PTR2 PF00854.21 CCM03467.1 - 2.8e-79 266.8 6.3 3.7e-79 266.4 6.3 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 CCM03467.1 - 5.6e-09 35.4 23.3 1.2e-08 34.2 23.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily CCB1 PF12046.8 CCM03467.1 - 0.013 14.9 0.1 0.025 13.9 0.1 1.4 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B Phage_holin_3_6 PF07332.11 CCM03467.1 - 0.44 10.6 8.1 8.7 6.4 1.4 3.4 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III His_Phos_2 PF00328.22 CCM03468.1 - 2.5e-33 116.0 0.0 7.2e-33 114.5 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Rad17 PF03215.15 CCM03469.1 - 5.8e-26 91.6 0.0 7.3e-19 68.4 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_16 PF13191.6 CCM03469.1 - 0.00015 22.2 0.3 0.00043 20.7 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 CCM03469.1 - 0.0006 20.4 0.0 0.0083 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCM03469.1 - 0.0011 19.2 0.0 0.0039 17.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CCM03469.1 - 0.0015 19.0 0.0 0.0034 17.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CCM03469.1 - 0.0048 16.6 0.0 0.0097 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 CCM03469.1 - 0.0064 16.8 0.0 0.019 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_33 PF13671.6 CCM03469.1 - 0.037 14.2 0.1 0.16 12.1 0.1 2.2 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 CCM03469.1 - 0.055 13.5 0.0 0.17 11.9 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Herpes_Helicase PF02689.14 CCM03469.1 - 0.056 11.4 0.0 0.079 10.9 0.0 1.1 1 0 0 1 1 1 0 Helicase AAA_6 PF12774.7 CCM03469.1 - 0.061 12.3 0.0 0.095 11.7 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Cytidylate_kin PF02224.18 CCM03469.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_14 PF13173.6 CCM03469.1 - 0.19 11.7 0.0 4.7 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain 3-HAO PF06052.12 CCM03470.1 - 2.9e-58 195.8 0.0 3.3e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 CCM03470.1 - 2e-07 30.6 0.1 3.1e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CCM03470.1 - 0.009 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 CCM03470.1 - 0.017 14.7 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 Cupin zf-tcix PF14952.6 CCM03470.1 - 0.034 13.8 0.2 0.063 12.9 0.2 1.3 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding Pkinase PF00069.25 CCM03476.1 - 1.3e-07 31.3 0.0 6e-07 29.1 0.0 2.2 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03476.1 - 0.00011 21.6 0.0 0.00049 19.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM03476.1 - 0.021 13.6 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Corona_NS1 PF06145.11 CCM03476.1 - 0.031 13.8 0.9 0.094 12.2 0.9 1.8 1 0 0 1 1 1 0 Coronavirus nonstructural protein NS1 ThiF PF00899.21 CCM03477.1 - 6.4e-63 212.4 0.0 7.2e-63 212.2 0.0 1.0 1 0 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.6 CCM03477.1 - 0.00014 22.3 0.0 0.00034 21.0 0.0 1.6 1 1 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CCM03477.1 - 0.043 13.9 0.0 0.07 13.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.23 CCM03477.1 - 0.055 13.6 0.1 0.083 13.0 0.1 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCM03477.1 - 0.26 11.5 0.5 3.6 7.9 0.5 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain UBA_e1_thiolCys PF10585.9 CCM03478.1 - 2e-08 34.5 0.0 3.6e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 CCM03478.1 - 2.3e-06 28.1 0.2 5.7e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain ThiF PF00899.21 CCM03478.1 - 9.8e-06 25.1 0.0 1.3e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 ThiF family DUF4138 PF13595.6 CCM03481.1 - 0.0096 15.2 0.0 0.022 14.0 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4138) PDR_CDR PF06422.12 CCM03481.1 - 6.4 6.7 13.2 0.17 11.8 0.4 3.2 3 1 1 4 4 4 0 CDR ABC transporter PTCB-BRCT PF12738.7 CCM03482.1 - 5.7e-26 90.2 5.2 3.5e-17 62.1 0.7 3.4 4 0 0 4 4 4 2 twin BRCT domain BRCT PF00533.26 CCM03482.1 - 1.3e-16 60.8 0.0 5.9e-09 36.2 0.0 3.9 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CCM03482.1 - 1.5e-12 47.7 0.0 0.00016 22.0 0.0 3.9 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CCM03482.1 - 6.8e-06 26.3 0.0 0.42 10.9 0.0 3.5 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 CCM03482.1 - 0.0043 17.1 0.1 0.13 12.4 0.1 3.0 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain RabGAP-TBC PF00566.18 CCM03483.1 - 1.9e-32 112.7 0.0 2.9e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SH3_2 PF07653.17 CCM03483.1 - 0.0038 16.9 0.0 0.018 14.7 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain Ribosomal_S17 PF00366.20 CCM03484.1 - 1.1e-21 76.6 0.1 1.7e-21 76.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Prefoldin_2 PF01920.20 CCM03485.1 - 4.7e-23 81.2 10.7 6.6e-23 80.7 10.7 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 CCM03485.1 - 0.011 15.6 10.8 0.28 11.1 3.0 2.2 2 0 0 2 2 2 0 Prefoldin subunit NPV_P10 PF05531.12 CCM03485.1 - 0.018 15.5 8.1 0.35 11.4 0.8 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Rx_N PF18052.1 CCM03485.1 - 0.03 14.6 6.0 0.1 12.9 0.6 2.2 2 0 0 2 2 2 0 Rx N-terminal domain DUF4139 PF13598.6 CCM03485.1 - 0.036 13.8 1.0 0.044 13.5 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) DUF1664 PF07889.12 CCM03485.1 - 0.038 14.0 4.8 1.5 8.9 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Tup_N PF08581.10 CCM03485.1 - 0.044 14.1 7.2 2.6 8.4 0.5 3.0 1 1 1 2 2 2 0 Tup N-terminal ERM PF00769.19 CCM03485.1 - 0.048 13.5 7.7 0.068 13.0 7.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family betaPIX_CC PF16523.5 CCM03485.1 - 0.078 12.8 0.4 0.078 12.8 0.4 2.2 1 1 1 2 2 2 0 betaPIX coiled coil Prefoldin_3 PF13758.6 CCM03485.1 - 0.081 13.0 4.7 1.3 9.1 3.7 2.2 1 1 1 2 2 2 0 Prefoldin subunit End3 PF12761.7 CCM03485.1 - 0.1 12.8 8.7 0.22 11.7 8.7 1.5 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Seryl_tRNA_N PF02403.22 CCM03485.1 - 0.12 12.6 8.4 3.1 8.1 8.3 2.2 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF641 PF04859.12 CCM03485.1 - 0.13 12.6 8.7 1.1 9.6 8.1 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) MscS_porin PF12795.7 CCM03485.1 - 0.13 11.8 13.6 0.083 12.4 4.0 2.1 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain Nsp1_C PF05064.13 CCM03485.1 - 0.18 11.6 9.7 1.5 8.7 2.0 2.1 1 1 0 2 2 2 0 Nsp1-like C-terminal region Occludin_ELL PF07303.13 CCM03485.1 - 0.2 12.4 4.5 4.6 8.0 0.3 2.1 2 0 0 2 2 2 0 Occludin homology domain Bcr-Abl_Oligo PF09036.10 CCM03485.1 - 0.2 11.7 2.3 0.39 10.8 0.2 2.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Tropomyosin_1 PF12718.7 CCM03485.1 - 0.2 11.8 9.7 0.67 10.1 1.0 2.2 2 0 0 2 2 2 0 Tropomyosin like MCU PF04678.13 CCM03485.1 - 0.22 11.6 5.0 0.43 10.6 5.0 1.5 1 1 0 1 1 1 0 Mitochondrial calcium uniporter FlaC_arch PF05377.11 CCM03485.1 - 0.22 11.9 7.4 4.2 7.9 1.1 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) YojJ PF10372.9 CCM03485.1 - 0.23 11.6 3.2 1.5 9.0 0.9 2.5 2 1 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus YabA PF06156.13 CCM03485.1 - 0.24 12.1 9.1 0.27 11.9 1.7 2.1 1 1 1 2 2 2 0 Initiation control protein YabA GAS PF13851.6 CCM03485.1 - 0.25 10.7 11.8 0.99 8.7 11.8 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding HIP1_clath_bdg PF16515.5 CCM03485.1 - 0.26 11.9 9.6 1.2 9.7 1.4 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fez1 PF06818.15 CCM03485.1 - 0.3 11.5 9.3 1 9.8 1.4 1.9 1 1 1 2 2 2 0 Fez1 Spc7 PF08317.11 CCM03485.1 - 0.42 9.4 12.2 1 8.2 12.2 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Spc24 PF08286.11 CCM03485.1 - 0.45 10.8 8.0 2.1 8.6 2.5 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Cluap1 PF10234.9 CCM03485.1 - 0.47 9.8 10.3 1.6 8.1 10.3 1.7 1 1 0 1 1 1 0 Clusterin-associated protein-1 APG6_N PF17675.1 CCM03485.1 - 1.2 9.6 12.2 48 4.5 12.2 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Syntaxin_2 PF14523.6 CCM03485.1 - 1.5 9.2 8.6 4.9 7.6 1.0 2.2 1 1 1 2 2 2 0 Syntaxin-like protein DUF724 PF05266.14 CCM03485.1 - 1.8 8.4 10.7 4.3 7.1 3.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DMPK_coil PF08826.10 CCM03485.1 - 1.9 8.7 13.2 0.93 9.7 3.6 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like COG2 PF06148.11 CCM03485.1 - 2 8.5 9.8 6.8 6.8 2.2 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.10 CCM03485.1 - 4.5 7.5 9.0 27 5.0 9.0 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 CCM03485.1 - 4.6 7.8 9.6 5.7 7.5 3.7 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 V-SNARE PF05008.15 CCM03486.1 - 3.4e-21 75.4 5.3 3.4e-21 75.4 5.3 2.3 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 CCM03486.1 - 1.9e-14 53.7 7.8 1.9e-14 53.7 7.8 2.1 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CCM03486.1 - 0.0016 18.3 0.3 0.0016 18.3 0.3 1.9 2 1 0 2 2 2 1 Sec20 DUF2564 PF10819.8 CCM03486.1 - 0.024 15.0 4.2 0.54 10.7 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) Prominin PF05478.11 CCM03486.1 - 0.054 11.5 3.2 0.22 9.4 0.2 2.0 2 0 0 2 2 2 0 Prominin SNARE PF05739.19 CCM03486.1 - 0.073 13.1 6.2 0.2 11.7 1.7 2.7 2 0 0 2 2 2 0 SNARE domain DUF3671 PF12420.8 CCM03486.1 - 0.092 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function Exonuc_VII_L PF02601.15 CCM03486.1 - 0.65 9.5 11.6 8.5 5.8 11.6 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit TBCA PF02970.16 CCM03486.1 - 0.87 10.0 11.2 4.3 7.7 3.5 2.4 2 0 0 2 2 2 0 Tubulin binding cofactor A Fib_alpha PF08702.10 CCM03486.1 - 2.4 8.3 9.9 3.3 7.9 0.7 2.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 CCM03486.1 - 3.2 6.9 7.3 6.8 5.8 2.5 2.1 2 0 0 2 2 2 0 TMPIT-like protein Mpv17_PMP22 PF04117.12 CCM03487.1 - 1.6e-23 82.7 0.6 3.7e-23 81.5 0.6 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family ArAE_2 PF10334.9 CCM03488.1 - 4.5e-56 190.3 0.1 6.9e-56 189.6 0.1 1.3 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 CCM03488.1 - 5.7e-32 111.4 16.8 1.7e-29 103.2 12.2 3.8 3 1 0 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 CCM03488.1 - 1.3e-07 31.7 17.0 1.3e-07 31.7 17.0 3.3 2 1 0 2 2 2 1 Fusaric acid resistance protein-like LSM PF01423.22 CCM03489.1 - 7.1e-15 54.4 0.1 8.4e-15 54.2 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CCM03489.1 - 6.5e-05 23.0 0.1 7.8e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 CCM03489.1 - 0.21 11.2 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Hfq protein UL42 PF17638.2 CCM03489.1 - 3.2 7.7 9.7 3.9 7.5 9.7 1.2 1 0 0 1 1 1 0 HCMV UL42 Zn_clus PF00172.18 CCM03490.1 - 2.1e-09 37.3 9.5 3.2e-09 36.8 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ILVD_EDD PF00920.21 CCM03491.1 - 6.3e-156 520.0 0.0 7.7e-156 519.7 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family RIO1 PF01163.22 CCM03492.1 - 9.1e-50 168.9 2.6 3e-35 121.5 0.0 2.7 3 0 0 3 3 3 2 RIO1 family DUF4662 PF15578.6 CCM03492.1 - 0.78 9.5 6.2 1.2 8.8 6.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) RAP1 PF07218.11 CCM03494.1 - 4 5.6 7.1 5.2 5.2 7.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Wzy_C PF04932.15 CCM03495.1 - 3.3 7.3 5.3 0.74 9.4 0.7 2.1 2 1 0 2 2 2 0 O-Antigen ligase AAA_23 PF13476.6 CCM03496.1 - 1.3e-14 55.2 58.0 1.3e-14 55.2 58.0 8.1 2 2 0 2 2 1 1 AAA domain AAA_15 PF13175.6 CCM03496.1 - 8.9e-14 52.0 65.1 3.7e-09 36.8 0.7 4.6 1 1 2 4 4 4 2 AAA ATPase domain AAA_21 PF13304.6 CCM03496.1 - 2.1e-12 47.5 4.7 2.9e-05 24.0 0.1 4.2 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM03496.1 - 2.1e-09 37.2 0.0 2.1e-09 37.2 0.0 3.0 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CCM03496.1 - 1.3e-06 28.5 0.0 7.7e-06 26.1 0.0 2.4 1 1 1 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CCM03496.1 - 0.0007 19.3 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 CCM03496.1 - 0.001 17.8 0.0 0.001 17.8 0.0 7.1 3 2 4 8 8 8 4 AAA domain TMF_DNA_bd PF12329.8 CCM03496.1 - 0.0087 16.0 0.5 0.0087 16.0 0.5 13.5 6 3 7 14 14 13 2 TATA element modulatory factor 1 DNA binding Roc PF08477.13 CCM03496.1 - 0.05 13.8 0.0 0.24 11.6 0.0 2.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pox_A_type_inc PF04508.12 CCM03496.1 - 0.054 13.4 9.8 0.026 14.4 2.5 4.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Rad50_zn_hook PF04423.14 CCM03496.1 - 0.08 12.8 9.5 0.06 13.2 0.3 5.6 3 1 1 4 4 3 0 Rad50 zinc hook motif AAA_16 PF13191.6 CCM03496.1 - 0.24 11.8 0.0 0.24 11.8 0.0 4.5 4 1 0 4 4 3 0 AAA ATPase domain GTP_EFTU PF00009.27 CCM03496.1 - 0.3 10.6 0.0 0.3 10.6 0.0 3.3 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain DUF2001 PF09393.10 CCM03496.1 - 0.69 9.9 7.7 0.88 9.6 0.0 4.0 4 0 0 4 4 3 0 Phage tail tube protein AAA_22 PF13401.6 CCM03496.1 - 0.89 9.8 0.0 0.89 9.8 0.0 3.6 3 1 0 3 3 3 0 AAA domain HTH_18 PF12833.7 CCM03496.1 - 2.2 8.6 4.1 20 5.5 0.0 3.3 4 0 0 4 4 3 0 Helix-turn-helix domain AAA_19 PF13245.6 CCM03496.1 - 6.6 7.1 10.0 2.7 8.3 0.0 4.1 4 0 0 4 4 4 0 AAA domain DUF2205 PF10224.9 CCM03497.1 - 1.5e-10 40.9 0.9 1.7e-10 40.8 0.9 1.1 1 0 0 1 1 1 1 Short coiled-coil protein YabA PF06156.13 CCM03497.1 - 0.0062 17.2 0.9 0.007 17.0 0.9 1.1 1 0 0 1 1 1 1 Initiation control protein YabA INT_SG_DDX_CT_C PF15300.6 CCM03497.1 - 0.078 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus RBD-FIP PF09457.10 CCM03497.1 - 0.15 12.0 0.9 0.57 10.1 0.9 1.9 1 1 0 1 1 1 0 FIP domain Proteasom_Rpn13 PF04683.13 CCM03498.1 - 4.9e-29 100.7 0.0 6.4e-29 100.3 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 CCM03499.1 - 8.3e-29 100.0 0.0 9.3e-29 99.9 0.0 1.1 1 0 0 1 1 1 1 UCH-binding domain Arf PF00025.21 CCM03500.1 - 3.7e-35 120.9 0.0 3.8e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CCM03500.1 - 4.9e-18 65.3 0.0 5.9e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM03500.1 - 9e-15 55.0 0.0 1.2e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCM03500.1 - 2.4e-08 33.6 0.0 2.9e-08 33.4 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCM03500.1 - 3.2e-07 30.0 0.0 3.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM03500.1 - 5.2e-06 26.5 0.0 6.7e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 CCM03500.1 - 6.7e-06 25.5 0.7 6.7e-05 22.2 0.1 2.2 1 1 1 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.27 CCM03500.1 - 0.025 14.1 0.0 0.038 13.5 0.0 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CCM03500.1 - 0.045 13.8 0.6 0.53 10.3 0.8 2.0 1 1 0 2 2 2 0 Dynamin family DUF751 PF05421.11 CCM03500.1 - 0.14 12.9 0.4 0.26 12.0 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF751) Pet127 PF08634.10 CCM03501.1 - 1.8e-102 342.5 0.0 2.7e-102 341.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Usp PF00582.26 CCM03502.1 - 1.1e-10 42.2 3.1 5e-10 40.0 0.0 2.9 3 0 0 3 3 3 1 Universal stress protein family F-box-like PF12937.7 CCM03503.1 - 0.08 12.8 0.2 0.17 11.8 0.2 1.6 1 0 0 1 1 1 0 F-box-like L27_2 PF09045.10 CCM03503.1 - 0.2 11.6 0.2 1.4 8.9 0.0 2.3 2 0 0 2 2 2 0 L27_2 F-box PF00646.33 CCM03503.1 - 1.1 9.2 3.4 0.95 9.4 0.4 2.5 2 1 0 2 2 2 0 F-box domain Pkinase PF00069.25 CCM03504.1 - 3e-67 226.8 0.0 4.2e-67 226.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03504.1 - 4.2e-37 127.8 0.0 1.3e-35 123.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM03504.1 - 0.00078 18.8 0.0 0.0025 17.2 0.0 1.8 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCM03504.1 - 0.0029 16.4 0.0 0.0078 15.0 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 CCM03504.1 - 0.053 12.6 0.4 0.13 11.2 0.1 1.8 3 0 0 3 3 3 0 Seadornavirus VP7 APH PF01636.23 CCM03504.1 - 0.077 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 CCM03504.1 - 0.14 11.7 0.1 0.36 10.4 0.0 1.7 1 1 0 1 1 1 0 RIO1 family DUF2235 PF09994.9 CCM03505.1 - 1.2e-88 297.2 0.0 1.9e-88 296.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Pkinase PF00069.25 CCM03506.1 - 1.1e-53 182.3 0.0 1.8e-53 181.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03506.1 - 1.1e-33 116.7 0.0 1.7e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Cullin PF00888.22 CCM03506.1 - 4.2e-18 65.3 0.0 8.8e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 CCM03506.1 - 3.8e-13 49.7 0.7 2.8e-12 47.0 0.0 2.8 3 0 0 3 3 3 1 Anaphase promoting complex (APC) subunit 2 Pkinase_fungal PF17667.1 CCM03506.1 - 1.5e-05 23.9 0.0 3e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCM03506.1 - 7.1e-05 22.3 0.0 0.00019 20.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Plk4_PB2 PF18409.1 CCM03506.1 - 0.0048 17.6 0.0 0.021 15.5 0.0 2.2 2 0 0 2 2 2 1 Polo-like Kinase 4 Polo Box 2 Plk4_PB1 PF18190.1 CCM03506.1 - 0.028 14.6 0.0 0.058 13.6 0.0 1.6 1 0 0 1 1 1 0 Polo-like Kinase 4 Polo Box 1 APH PF01636.23 CCM03506.1 - 0.037 13.9 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_S9 PF00326.21 CCM03507.1 - 1.2e-11 44.5 0.1 1.5e-06 27.9 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCM03507.1 - 5.6e-08 32.9 0.2 0.00041 20.3 0.1 2.3 1 1 0 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 CCM03507.1 - 9.7e-06 25.3 0.0 0.02 14.5 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S15 PF02129.18 CCM03507.1 - 0.0002 21.1 0.0 0.0013 18.4 0.0 1.9 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 CCM03507.1 - 0.012 14.9 0.1 2 7.6 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CCM03507.1 - 0.04 13.6 0.8 0.11 12.1 0.8 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 CCM03507.1 - 0.06 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 CCM03507.1 - 0.075 13.6 3.2 0.1 13.2 2.7 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family AXE1 PF05448.12 CCM03507.1 - 0.092 11.4 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) COesterase PF00135.28 CCM03507.1 - 0.18 10.6 0.0 0.23 10.3 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family SIR2 PF02146.17 CCM03508.1 - 2.9e-59 199.9 0.0 3.9e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Peptidase_S28 PF05577.12 CCM03509.1 - 9.2e-56 189.5 0.0 4.2e-55 187.3 0.0 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 F-box-like PF12937.7 CCM03510.1 - 2.5e-06 27.3 0.5 2.5e-06 27.3 0.5 2.8 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CCM03510.1 - 0.11 12.4 4.6 0.69 9.9 1.5 3.7 2 1 0 2 2 2 0 F-box domain peroxidase PF00141.23 CCM03511.1 - 4e-21 75.8 0.0 5.6e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Peroxidase YjeF_N PF03853.15 CCM03512.1 - 1.9e-35 122.3 0.0 3.2e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus EBP PF05241.12 CCM03513.1 - 2.6e-68 229.0 10.5 3e-68 228.8 10.5 1.0 1 0 0 1 1 1 1 Emopamil binding protein 7tm_1 PF00001.21 CCM03513.1 - 0.024 13.9 0.1 0.044 13.1 0.1 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Amidohydro_1 PF01979.20 CCM03514.1 - 1.4e-47 162.7 0.0 1.9e-47 162.3 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCM03514.1 - 1.5e-07 31.3 0.1 1.3e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family BTB PF00651.31 CCM03515.1 - 5.1e-07 29.9 0.0 1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Mon1 PF03164.14 CCM03516.1 - 2.3e-120 402.4 0.0 3e-120 402.0 0.0 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 SEEK1 PF15357.6 CCM03516.1 - 0.035 14.3 0.1 0.1 12.7 0.1 1.7 1 0 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 IGR PF09597.10 CCM03517.1 - 1.9e-19 69.5 0.3 3.1e-19 68.8 0.3 1.4 1 0 0 1 1 1 1 IGR protein motif FHA PF00498.26 CCM03518.1 - 1.7e-17 63.5 0.0 3.1e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCM03518.1 - 1.1e-06 28.8 0.0 4.1e-05 23.8 0.0 2.2 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain ErmC PF06308.11 CCM03518.1 - 0.34 11.3 0.2 0.34 11.3 0.2 2.1 2 1 1 3 3 3 0 23S rRNA methylastransferase leader peptide (ErmCL) Lipase_3 PF01764.25 CCM03519.1 - 1.4e-18 67.1 0.0 2.3e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCM03519.1 - 0.0012 19.5 0.4 0.0031 18.2 0.1 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CCM03519.1 - 0.077 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 CCM03519.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain DUF2974 PF11187.8 CCM03519.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) zf-CRD PF17979.1 CCM03520.1 - 7.3e-09 35.9 1.4 1.4e-08 35.0 0.0 2.1 2 0 0 2 2 2 1 Cysteine rich domain with multizinc binding regions Zn_clus PF00172.18 CCM03520.1 - 1e-07 31.9 10.6 1e-07 31.9 10.6 2.4 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CCHH PF10283.9 CCM03520.1 - 0.036 14.0 0.1 0.18 11.8 0.1 2.3 1 0 0 1 1 1 0 PBZ domain Kelch_5 PF13854.6 CCM03521.1 - 1.4e-15 56.9 0.3 0.00047 20.1 0.1 3.8 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 CCM03521.1 - 6.1e-14 51.9 5.0 9.2e-07 29.0 0.0 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 CCM03521.1 - 5.4e-13 48.3 2.8 0.00023 20.7 0.0 4.4 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 CCM03521.1 - 3.7e-12 45.7 0.7 0.0039 17.1 0.0 4.4 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 CCM03521.1 - 6.6e-12 45.3 2.6 0.053 13.8 0.0 5.2 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 CCM03521.1 - 1.7e-10 40.7 4.2 0.0011 19.0 0.0 4.7 5 0 0 5 5 5 3 Galactose oxidase, central domain BTB PF00651.31 CCM03521.1 - 0.086 13.1 0.5 14 6.0 0.0 2.9 3 0 0 3 3 3 0 BTB/POZ domain Putative_PNPOx PF01243.20 CCM03522.1 - 4.1e-23 81.4 0.0 9e-23 80.3 0.0 1.5 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 CCM03522.1 - 2.2e-18 66.0 3.7 5.5e-18 64.8 2.7 2.2 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 CCM03522.1 - 1.1e-05 25.9 0.4 2.7e-05 24.7 0.2 1.7 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Fungal_trans PF04082.18 CCM03523.1 - 6.9e-12 44.9 0.2 1.2e-11 44.2 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4743 PF15916.5 CCM03523.1 - 0.12 12.3 0.1 4.5 7.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4743) AOX PF01786.17 CCM03525.1 - 8.6e-98 326.2 0.1 1e-97 325.9 0.1 1.1 1 0 0 1 1 1 1 Alternative oxidase Peptidase_S66C PF17676.1 CCM03525.1 - 0.046 14.2 0.0 0.09 13.3 0.0 1.5 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain PH_4 PF15404.6 CCM03526.1 - 8e-19 68.1 1.2 2.4e-16 60.1 0.8 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 CCM03526.1 - 0.16 11.8 0.9 0.26 11.1 0.2 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain Ribosom_S12_S23 PF00164.25 CCM03527.1 - 7.2e-30 102.9 0.9 9.1e-30 102.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 zf-Nse PF11789.8 CCM03528.1 - 1.7e-14 53.4 0.0 2.8e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 CCM03528.1 - 0.0019 18.0 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PRP9_N PF16958.5 CCM03528.1 - 0.0039 17.2 0.8 0.011 15.8 0.8 1.7 1 0 0 1 1 1 1 Pre-mRNA-splicing factor PRP9 N-terminus zf-RING_UBOX PF13445.6 CCM03528.1 - 0.004 17.1 0.2 0.0093 16.0 0.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCM03528.1 - 0.074 13.4 0.4 0.34 11.3 0.2 2.1 2 0 0 2 2 2 0 Ring finger domain MRP-L47 PF06984.13 CCM03529.1 - 1.8e-21 76.0 3.2 2.1e-21 75.8 1.5 2.0 3 0 0 3 3 3 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 CCM03529.1 - 0.016 15.1 1.6 0.087 12.8 1.6 2.2 1 1 0 1 1 1 0 Ribosomal L29 protein SQS_PSY PF00494.19 CCM03530.1 - 5.2e-58 196.6 0.1 6e-58 196.4 0.1 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase baeRF_family5 PF18846.1 CCM03531.1 - 1.6 9.0 5.2 6.6 6.9 1.5 2.5 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 Glyco_hydro_71 PF03659.14 CCM03533.1 - 1.3e-126 422.4 7.4 1.9e-126 421.9 7.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 zf-RING_UBOX PF13445.6 CCM03534.1 - 0.027 14.5 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 RING-type zinc-finger GP63 PF17471.2 CCM03534.1 - 0.052 13.7 0.0 0.083 13.1 0.0 1.3 1 0 0 1 1 1 0 Gene product 63 GLYCAM-1 PF05242.11 CCM03534.1 - 0.76 9.9 4.5 1 9.5 1.4 2.2 2 0 0 2 2 2 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) WRNPLPNID PF15017.6 CCM03534.1 - 3.1 8.7 8.9 23 5.9 0.3 2.5 2 1 0 2 2 2 0 Putative WW-binding domain and destruction box HAD_2 PF13419.6 CCM03535.1 - 4.8e-06 26.8 0.0 1.9e-05 24.9 0.0 1.9 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM03535.1 - 1.3e-05 25.2 0.0 2.3e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CCM03535.1 - 3.2e-05 24.3 0.1 0.029 14.7 0.0 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase CS PF04969.16 CCM03536.1 - 2.3e-09 38.1 0.0 7.8e-09 36.4 0.0 1.9 2 0 0 2 2 2 1 CS domain PP2C PF00481.21 CCM03537.1 - 1.3e-57 195.4 0.8 6.3e-28 98.1 0.1 2.3 1 1 1 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 CCM03537.1 - 6.3e-05 23.0 0.1 6.3e-05 23.0 0.1 2.1 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) CDC45 PF02724.14 CCM03537.1 - 9.5 4.4 7.8 13 4.0 7.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Scm3 PF10384.9 CCM03538.1 - 1.1e-11 44.2 0.1 1.1e-11 44.2 0.1 3.7 5 0 0 5 5 5 1 Centromere protein Scm3 CBM_19 PF03427.13 CCM03540.1 - 0.11 12.5 0.1 0.11 12.5 0.1 2.3 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) BUD22 PF09073.10 CCM03541.1 - 1.6e-79 268.3 16.8 1.8e-79 268.1 16.8 1.0 1 0 0 1 1 1 1 BUD22 DIOX_N PF14226.6 CCM03542.1 - 4.5e-30 104.8 0.0 6.6e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM03542.1 - 2.8e-17 63.0 0.0 4.5e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TFCD_C PF12612.8 CCM03543.1 - 3e-39 134.8 0.0 7.6e-38 130.2 0.0 2.8 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 CCM03543.1 - 0.00018 21.5 7.6 0.2 12.0 0.0 6.7 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 CCM03543.1 - 0.005 16.9 0.1 0.27 11.2 0.0 3.6 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.7 CCM03543.1 - 0.047 12.9 0.1 0.49 9.5 0.0 2.5 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 CCM03543.1 - 0.057 13.6 0.1 2.9 8.1 0.0 3.2 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 CCM03543.1 - 0.47 10.9 9.2 0.83 10.1 0.0 5.2 6 1 0 6 6 6 0 HEAT repeats ATP-synt_ab PF00006.25 CCM03544.1 - 8.3e-68 228.2 0.0 1.2e-67 227.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CCM03544.1 - 1.3e-12 48.1 0.7 2.2e-12 47.3 0.7 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Tcp11 PF05794.13 CCM03545.1 - 1.6e-98 330.7 0.0 2e-98 330.4 0.0 1.1 1 0 0 1 1 1 1 T-complex protein 11 DUF4954 PF16314.5 CCM03546.1 - 0.021 13.0 0.8 0.022 12.9 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Peptidase_S9 PF00326.21 CCM03548.1 - 8.3e-50 169.2 0.2 2.6e-49 167.6 0.2 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCM03548.1 - 5.3e-05 23.0 0.1 0.31 10.6 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 CCM03548.1 - 0.00053 18.8 0.1 0.079 11.6 0.1 2.4 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) COesterase PF00135.28 CCM03548.1 - 0.067 12.1 0.1 0.11 11.3 0.1 1.3 1 0 0 1 1 1 0 Carboxylesterase family Hydrolase_4 PF12146.8 CCM03548.1 - 0.072 12.4 0.0 10 5.3 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 AAA PF00004.29 CCM03549.1 - 1.9e-40 138.3 0.0 3.7e-40 137.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CCM03549.1 - 5.3e-20 71.1 0.1 1e-19 70.2 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CCM03549.1 - 8.6e-12 44.7 0.1 2e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCM03549.1 - 7e-05 23.3 0.2 0.013 15.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CCM03549.1 - 0.00044 20.3 0.2 0.0048 16.9 0.2 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCM03549.1 - 0.00084 19.6 0.5 0.076 13.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 CCM03549.1 - 0.0011 19.2 0.1 0.013 15.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CCM03549.1 - 0.0012 18.7 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 CCM03549.1 - 0.0025 17.3 0.1 0.051 13.0 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_33 PF13671.6 CCM03549.1 - 0.0057 16.8 0.0 0.017 15.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCM03549.1 - 0.0073 16.1 0.1 0.41 10.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CCM03549.1 - 0.017 14.6 0.0 0.042 13.2 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CCM03549.1 - 0.026 14.3 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 CCM03549.1 - 0.088 12.0 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 CCM03549.1 - 0.11 12.2 0.2 0.29 10.8 0.1 1.9 2 1 0 2 2 2 0 AAA domain XhlA PF10779.9 CCM03549.1 - 1.5 9.1 5.7 26 5.1 4.2 2.5 2 0 0 2 2 2 0 Haemolysin XhlA Rrp40_N PF18311.1 CCM03551.1 - 9.8e-15 54.2 0.2 1.8e-14 53.4 0.2 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain KH_6 PF15985.5 CCM03551.1 - 1.5e-13 50.8 0.0 2.8e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 KH domain Motile_Sperm PF00635.26 CCM03552.1 - 2.8e-27 94.7 0.2 4.9e-27 93.9 0.2 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 CCM03552.1 - 0.0058 16.8 0.1 0.014 15.6 0.1 1.6 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Spc42p PF11544.8 CCM03552.1 - 0.019 14.9 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Spindle pole body component Spc42p FixG_C PF11614.8 CCM03552.1 - 0.038 14.2 1.1 0.076 13.2 0.1 1.9 2 0 0 2 2 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF756 PF05506.12 CCM03552.1 - 0.14 13.1 0.0 0.29 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF756) Motile_Sperm PF00635.26 CCM03553.1 - 4e-26 91.0 0.4 5.1e-26 90.7 0.4 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 CCM03553.1 - 0.013 15.7 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 CCM03553.1 - 0.013 15.7 0.2 0.058 13.7 0.0 1.9 2 0 0 2 2 2 0 Transmembrane protein 131-like DUF5001 PF16392.5 CCM03553.1 - 0.041 13.8 0.1 0.078 12.9 0.1 1.6 1 1 0 1 1 1 0 Ig-like domain ABC_membrane PF00664.23 CCM03554.1 - 6e-105 350.8 21.2 1.6e-52 178.9 7.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CCM03554.1 - 4.3e-68 228.1 0.0 3.2e-33 115.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CCM03554.1 - 5.9e-15 55.3 0.4 0.00014 21.4 0.0 4.1 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCM03554.1 - 1e-06 28.8 0.2 0.12 12.1 0.0 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM03554.1 - 3.1e-06 26.8 1.3 0.0082 15.9 0.4 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CCM03554.1 - 3.7e-06 26.4 0.0 0.013 14.8 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_16 PF13191.6 CCM03554.1 - 4.1e-06 27.3 3.7 0.038 14.4 0.1 3.5 2 2 1 3 3 3 2 AAA ATPase domain ABC_ATPase PF09818.9 CCM03554.1 - 4.5e-06 25.7 2.5 0.0044 15.9 0.0 2.5 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 CCM03554.1 - 1.6e-05 25.2 3.2 0.097 12.9 0.1 4.0 4 1 0 4 4 2 2 AAA domain AAA_15 PF13175.6 CCM03554.1 - 2.5e-05 24.2 0.0 0.066 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCM03554.1 - 5.8e-05 23.1 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 CCM03554.1 - 0.00017 21.3 2.8 0.58 9.8 0.0 3.9 4 1 0 4 4 4 2 AAA domain AAA_25 PF13481.6 CCM03554.1 - 0.00045 19.8 0.4 0.24 10.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 CCM03554.1 - 0.00079 20.0 1.7 0.96 9.9 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 CCM03554.1 - 0.0022 18.4 2.8 2.9 8.3 0.4 4.0 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 CCM03554.1 - 0.0023 17.1 0.0 0.72 9.0 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_18 PF13238.6 CCM03554.1 - 0.0026 18.3 0.0 4.6 7.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CCM03554.1 - 0.0026 17.9 0.0 1.4 9.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CCM03554.1 - 0.0032 17.0 0.0 0.92 9.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 CCM03554.1 - 0.0042 17.1 0.0 2.2 8.3 0.0 3.4 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CCM03554.1 - 0.0069 16.6 2.8 0.7 10.1 0.0 3.4 4 0 0 4 4 2 1 AAA domain APS_kinase PF01583.20 CCM03554.1 - 0.0079 16.1 0.0 0.18 11.7 0.0 2.5 2 0 0 2 2 2 1 Adenylylsulphate kinase DUF87 PF01935.17 CCM03554.1 - 0.012 15.7 0.1 7.9 6.5 0.0 3.0 3 0 0 3 3 2 0 Helicase HerA, central domain SbcCD_C PF13558.6 CCM03554.1 - 0.013 15.7 2.6 7.2 6.9 0.4 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF2628 PF10947.8 CCM03554.1 - 0.016 15.6 0.1 0.091 13.1 0.1 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) PRK PF00485.18 CCM03554.1 - 0.037 13.8 0.0 3.5 7.3 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 CCM03554.1 - 0.051 14.0 0.0 3.9 7.9 0.0 2.9 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.23 CCM03554.1 - 0.051 13.7 0.1 12 6.0 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 CCM03554.1 - 0.071 12.8 0.1 12 5.5 0.0 2.6 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 CCM03554.1 - 0.084 12.5 0.0 12 5.4 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 CCM03554.1 - 0.095 11.9 0.0 3.3 6.8 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain RHH_4 PF13467.6 CCM03554.1 - 0.14 12.0 0.0 11 5.9 0.0 2.8 2 0 0 2 2 2 0 Ribbon-helix-helix domain DUF815 PF05673.13 CCM03554.1 - 0.16 11.1 0.2 10 5.2 0.0 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 CCM03554.1 - 0.16 11.3 0.2 12 5.1 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Rad17 PF03215.15 CCM03554.1 - 0.16 11.9 0.1 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain Pkinase PF00069.25 CCM03555.1 - 1.3e-69 234.5 0.0 1.6e-69 234.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03555.1 - 2.4e-31 109.0 0.0 3.2e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCM03555.1 - 1.8e-10 41.3 0.6 1.8e-10 41.3 0.6 2.2 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CCM03555.1 - 1.5e-07 30.7 0.0 2.1e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCM03555.1 - 7.9e-05 22.1 0.0 0.00015 21.2 0.0 1.4 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CCM03555.1 - 0.0044 16.7 0.0 0.69 9.5 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CCM03555.1 - 0.028 13.8 0.1 0.047 13.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM03555.1 - 0.053 13.4 0.3 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM03555.1 - 0.15 11.6 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase G-patch PF01585.23 CCM03556.1 - 2.4e-05 24.1 0.5 0.00018 21.3 0.7 2.2 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CCM03556.1 - 0.026 14.6 1.1 0.15 12.2 0.7 2.2 2 0 0 2 2 2 0 G-patch domain F-box-like PF12937.7 CCM03557.1 - 5.5e-12 45.4 0.1 3.3e-11 42.9 0.1 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM03557.1 - 0.004 17.0 0.1 0.027 14.4 0.1 2.5 1 0 0 1 1 1 1 F-box domain DASH_Spc19 PF08287.11 CCM03557.1 - 0.028 14.3 1.2 6.3 6.7 0.0 2.3 2 0 0 2 2 2 0 Spc19 PQ-loop PF04193.14 CCM03558.1 - 1.4e-15 56.8 1.1 4.7e-15 55.1 1.1 1.9 1 0 0 1 1 1 1 PQ loop repeat Svf1_C PF17187.4 CCM03558.1 - 0.11 12.3 0.4 0.16 11.8 0.0 1.5 2 0 0 2 2 2 0 Svf1-like C-terminal lipocalin-like domain Band_7 PF01145.25 CCM03559.1 - 7.7e-21 74.9 1.3 1.1e-20 74.4 1.3 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family MutS_V PF00488.21 CCM03560.1 - 1e-40 139.8 1.1 1.2e-39 136.3 0.3 2.4 2 1 0 2 2 2 1 MutS domain V MutS_III PF05192.18 CCM03560.1 - 2.2e-31 109.6 0.0 5.1e-31 108.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain III DAP3 PF10236.9 CCM03560.1 - 0.095 11.9 0.2 1 8.5 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 CCM03560.1 - 0.1 12.9 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mito_carr PF00153.27 CCM03561.1 - 1.3e-38 130.8 3.3 1.7e-12 47.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NCA2 PF08637.10 CCM03563.1 - 5.4e-83 278.5 0.0 8.8e-83 277.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 PRP1_N PF06424.12 CCM03564.1 - 5e-33 114.6 2.5 5e-33 114.6 2.5 1.9 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CCM03564.1 - 1.4e-25 87.8 36.3 0.019 15.8 0.6 14.8 4 3 13 17 17 16 9 Tetratricopeptide repeat TPR_19 PF14559.6 CCM03564.1 - 2.1e-15 57.0 20.9 0.031 14.8 0.5 9.2 5 4 3 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 CCM03564.1 - 1.2e-14 54.6 23.8 3.3e-05 24.4 0.3 7.5 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 CCM03564.1 - 1.6e-09 37.1 6.4 0.62 10.3 0.0 8.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCM03564.1 - 4.4e-06 27.0 5.3 0.86 10.4 0.0 7.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCM03564.1 - 7e-05 22.9 0.6 16 6.2 0.0 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 CCM03564.1 - 7.2e-05 22.7 4.4 2.1 8.8 0.1 6.8 8 0 0 8 8 7 1 Tetratricopeptide repeat FAT PF02259.23 CCM03564.1 - 0.0014 17.9 9.6 0.095 11.9 0.3 4.4 3 1 1 5 5 5 2 FAT domain TPR_1 PF00515.28 CCM03564.1 - 0.005 16.6 0.1 19 5.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCM03564.1 - 0.013 15.8 4.5 41 4.6 0.0 5.3 4 1 1 5 5 5 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CCM03564.1 - 0.027 14.4 5.6 29 4.5 0.1 4.8 4 1 1 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal TPR_9 PF13371.6 CCM03564.1 - 0.044 13.9 16.6 1.4 9.1 0.1 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Crl PF07417.12 CCM03564.1 - 0.12 12.4 0.6 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 Sigma factor-binding transcriptional regulator Crl NARP1 PF12569.8 CCM03564.1 - 0.3 10.0 9.0 0.8 8.5 0.1 4.3 4 1 1 5 5 5 0 NMDA receptor-regulated protein 1 TPR_11 PF13414.6 CCM03564.1 - 0.34 10.6 2.8 3.9 7.2 0.2 3.9 3 1 1 4 4 4 0 TPR repeat TarH PF02203.15 CCM03564.1 - 5.8 6.8 8.3 6.9 6.6 1.1 3.7 3 0 0 3 3 3 0 Tar ligand binding domain homologue CMAS PF02353.20 CCM03566.1 - 8e-45 153.2 1.7 5.1e-32 111.3 0.9 3.8 2 1 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CCM03566.1 - 2.2e-06 28.3 0.0 9e-06 26.3 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM03566.1 - 0.00074 20.1 0.0 0.0018 18.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CCM03566.1 - 0.0029 16.7 0.0 0.0048 16.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 CCM03566.1 - 0.0034 17.0 0.0 0.007 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 CCM03566.1 - 0.0043 16.9 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 CCM03566.1 - 0.0082 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_12 PF08242.12 CCM03566.1 - 0.032 15.0 0.1 0.23 12.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 CCM03566.1 - 0.17 11.6 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Rif1_N PF12231.8 CCM03567.1 - 1e-05 24.7 1.3 1.8e-05 23.9 1.3 1.3 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal HEAT_EZ PF13513.6 CCM03567.1 - 0.0052 17.3 0.1 1.9 9.1 0.0 3.2 2 0 0 2 2 2 1 HEAT-like repeat HEAT PF02985.22 CCM03567.1 - 0.0085 16.3 0.4 0.56 10.6 0.1 3.5 2 0 0 2 2 2 1 HEAT repeat RIX1 PF08167.12 CCM03567.1 - 0.023 14.4 2.4 0.13 12.0 2.2 2.4 1 1 0 1 1 1 0 rRNA processing/ribosome biogenesis HEAT_2 PF13646.6 CCM03567.1 - 0.15 12.4 1.0 7.6 7.0 0.1 3.2 2 1 1 3 3 3 0 HEAT repeats CsbD PF05532.12 CCM03569.1 - 0.0053 16.6 2.7 0.01 15.7 2.7 1.5 1 0 0 1 1 1 1 CsbD-like Asp PF00026.23 CCM03570.1 - 1.7e-40 139.4 0.1 3.5e-40 138.4 0.0 1.5 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM03570.1 - 3.8e-06 27.3 4.3 0.0021 18.4 4.3 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCM03570.1 - 0.001 19.7 1.6 0.051 14.2 1.1 3.0 2 1 0 2 2 2 1 Aspartyl protease JmjN PF02375.17 CCM03571.1 - 0.15 12.0 0.1 0.7 9.9 0.0 2.1 2 0 0 2 2 2 0 jmjN domain IclR PF01614.18 CCM03571.1 - 0.23 11.3 0.6 0.45 10.3 0.6 1.4 1 0 0 1 1 1 0 Bacterial transcriptional regulator PARP PF00644.20 CCM03572.1 - 7.7e-06 25.6 0.9 2.6e-05 23.9 0.7 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP PF00644.20 CCM03573.1 - 9.2e-05 22.1 0.2 0.00026 20.6 0.2 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain YL1 PF05764.13 CCM03573.1 - 0.37 10.9 2.5 0.5 10.4 2.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein S36_mt PF10937.8 CCM03575.1 - 2.1e-11 45.4 2.9 2.5e-10 41.9 2.9 2.0 1 1 0 1 1 1 1 Ribosomal protein S36, mitochondrial DUF3275 PF11679.8 CCM03575.1 - 0.013 15.5 0.4 0.016 15.2 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Proteasome PF00227.26 CCM03576.1 - 2.5e-29 102.1 0.1 7.1e-29 100.6 0.1 1.7 1 1 0 1 1 1 1 Proteasome subunit RNA_pol_Rpb1_1 PF04997.12 CCM03577.1 - 1.4e-87 294.0 0.0 2.1e-87 293.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CCM03577.1 - 4.2e-84 282.1 0.3 6.2e-84 281.6 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCM03577.1 - 3.7e-72 241.9 0.0 7.3e-72 241.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CCM03577.1 - 9.6e-39 132.8 0.0 1.1e-37 129.4 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CCM03577.1 - 8.5e-31 106.1 0.0 2e-30 104.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 IRF PF00605.17 CCM03577.1 - 0.1 12.9 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Interferon regulatory factor transcription factor DUF2786 PF10979.8 CCM03577.1 - 0.12 12.3 0.2 0.29 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) GIT_SHD PF08518.11 CCM03578.1 - 6.9e-25 86.3 6.8 6.6e-13 48.0 3.0 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Golgin_A5 PF09787.9 CCM03578.1 - 0.58 9.6 29.4 3.5 7.0 29.4 2.2 1 1 0 1 1 1 0 Golgin subfamily A member 5 SpecificRecomb PF10136.9 CCM03578.1 - 0.58 8.4 6.5 0.98 7.6 3.5 2.3 2 0 0 2 2 2 0 Site-specific recombinase Lebercilin PF15619.6 CCM03578.1 - 1.3 8.6 27.9 2.8 7.6 19.4 3.8 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease BLOC1_2 PF10046.9 CCM03578.1 - 2.9 8.3 8.1 1.1 9.6 0.7 3.3 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 CCM03578.1 - 5.6 7.5 7.2 4.8 7.7 0.2 4.0 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Lipase_3 PF01764.25 CCM03579.1 - 8.7e-15 54.8 0.0 9e-13 48.3 0.0 2.3 2 0 0 2 2 2 2 Lipase (class 3) Hydrolase_4 PF12146.8 CCM03579.1 - 0.061 12.6 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Spt4 PF06093.13 CCM03580.1 - 2.1e-30 104.6 0.2 2.5e-30 104.4 0.2 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Thioredoxin_2 PF13098.6 CCM03580.1 - 0.058 13.8 0.0 0.077 13.5 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain Mito_carr PF00153.27 CCM03583.1 - 2.2e-14 53.1 0.0 2.7e-08 33.6 0.0 2.6 2 1 0 2 2 2 2 Mitochondrial carrier protein FAM176 PF14851.6 CCM03583.1 - 0.12 12.1 0.6 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 FAM176 family SNF2_N PF00176.23 CCM03584.1 - 2.1e-53 181.3 0.1 3.8e-53 180.4 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM03584.1 - 9.1e-18 64.6 0.0 2.9e-17 63.0 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM03584.1 - 3.1e-09 37.1 0.0 6.3e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_3 PF12836.7 CCM03584.1 - 0.0036 17.5 0.0 0.0089 16.3 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif Sybindin PF04099.12 CCM03585.1 - 2.7e-15 56.5 0.0 4.3e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Sybindin-like family Ank_4 PF13637.6 CCM03586.1 - 0.00026 21.5 0.8 0.0097 16.5 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM03586.1 - 0.0023 18.5 0.1 0.0048 17.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Peptidase_C107 PF17222.3 CCM03586.1 - 0.085 11.8 0.1 1.2 8.1 0.1 2.1 2 0 0 2 2 2 0 Viral cysteine endopeptidase C107 DUF1576 PF07613.11 CCM03586.1 - 0.15 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1576) Ribosomal_S8e PF01201.22 CCM03587.1 - 3.3e-48 163.3 0.3 3.3e-48 163.3 0.3 3.0 2 1 1 3 3 3 1 Ribosomal protein S8e DUF1168 PF06658.12 CCM03587.1 - 5e-39 133.2 11.4 5e-39 133.2 11.4 2.8 3 1 0 3 3 3 1 Protein of unknown function (DUF1168) Yip1 PF04893.17 CCM03588.1 - 0.00012 21.8 2.0 0.0002 21.2 2.0 1.3 1 0 0 1 1 1 1 Yip1 domain DUF1746 PF08508.10 CCM03590.1 - 1.6e-08 34.9 1.5 4.1e-08 33.6 1.5 1.7 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Rad10 PF03834.14 CCM03593.1 - 2.8e-42 143.3 0.0 6e-42 142.3 0.0 1.6 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Amidohydro_3 PF07969.11 CCM03593.1 - 3e-07 30.3 2.8 0.0017 17.9 0.0 3.3 4 0 0 4 4 4 2 Amidohydrolase family HHH_5 PF14520.6 CCM03593.1 - 3.6e-06 27.5 0.1 1.8e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain Amidohydro_1 PF01979.20 CCM03593.1 - 5.3e-06 26.0 0.1 0.014 14.7 0.0 3.0 3 0 0 3 3 3 2 Amidohydrolase family HHH_3 PF12836.7 CCM03593.1 - 0.0031 17.7 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.7 CCM03593.1 - 0.033 14.3 0.0 0.19 11.8 0.0 2.3 1 0 0 1 1 1 0 Helix-hairpin-helix motif TRP PF06011.12 CCM03594.1 - 1.2e-47 162.7 19.8 2.6e-47 161.5 19.9 1.3 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel SID-1_RNA_chan PF13965.6 CCM03594.1 - 1.6 7.0 21.1 0.79 8.1 4.6 3.0 2 1 1 3 3 3 0 dsRNA-gated channel SID-1 OSCP PF00213.18 CCM03595.1 - 1.2e-40 139.4 1.5 1.4e-40 139.2 1.5 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Amidohydro_1 PF01979.20 CCM03596.1 - 3.8e-13 49.5 0.0 2.8e-12 46.6 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CCM03596.1 - 4.9e-12 46.1 2.6 3.9e-07 29.9 0.1 3.0 3 1 0 3 3 3 2 Amidohydrolase family Hist_deacetyl PF00850.19 CCM03597.1 - 6.2e-83 278.8 0.1 1.6e-82 277.4 0.0 1.7 2 0 0 2 2 2 1 Histone deacetylase domain Arb2 PF09757.9 CCM03597.1 - 7.9e-39 133.3 0.0 1.2e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain Paramyxo_P PF01806.17 CCM03599.1 - 0.18 11.2 0.3 0.28 10.6 0.3 1.2 1 0 0 1 1 1 0 Paramyxovirinae P phosphoprotein C-terminal region HET PF06985.11 CCM03600.1 - 6.6e-12 46.0 5.0 8.2e-11 42.4 0.5 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) zf-C2H2 PF00096.26 CCM03601.1 - 0.23 12.0 0.1 0.23 12.0 0.1 2.5 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM03601.1 - 1.2 10.2 0.1 1.2 10.2 0.1 3.2 2 1 0 2 2 2 0 C2H2-type zinc finger DUF1752 PF08550.10 CCM03602.1 - 7.2e-13 48.1 3.3 1.7e-12 46.9 3.3 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF3295 PF11702.8 CCM03602.1 - 7e-10 38.9 14.3 7e-10 38.9 14.3 3.1 1 1 2 3 3 3 1 Protein of unknown function (DUF3295) 2OG-FeII_Oxy PF03171.20 CCM03603.1 - 3.3e-14 53.2 0.0 7.5e-14 52.0 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCM03603.1 - 0.00016 22.4 0.1 0.0053 17.5 0.1 2.9 3 1 0 3 3 3 1 non-haem dioxygenase in morphine synthesis N-terminal OppC_N PF12911.7 CCM03604.1 - 0.34 10.9 1.7 5.9 6.9 0.1 2.5 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Hid1 PF12722.7 CCM03604.1 - 0.52 8.4 7.4 0.67 8.0 7.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SPX PF03105.19 CCM03604.1 - 2.3 8.1 15.6 0.27 11.1 11.6 1.5 2 0 0 2 2 2 0 SPX domain ORC6 PF05460.13 CCM03604.1 - 4.6 6.4 16.9 9 5.5 16.9 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DnaJ_C PF01556.18 CCM03605.1 - 4.1e-23 82.1 0.0 6.5e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCM03605.1 - 4.9e-17 61.8 0.2 1e-16 60.8 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain SOG2 PF10428.9 CCM03605.1 - 1.3 8.1 27.3 2.1 7.4 27.3 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein DUF5523 PF17661.1 CCM03605.1 - 7.8 6.1 17.8 0.69 9.5 4.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Drf_GBD PF06371.13 CCM03607.1 - 2.3e-16 59.9 0.7 2.4e-15 56.6 0.7 2.0 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain WD40 PF00400.32 CCM03608.1 - 2.7e-14 53.3 6.1 0.0064 17.3 0.2 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 CCM03608.1 - 0.051 12.2 1.1 0.25 10.0 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 eIF3_subunit PF08597.10 CCM03609.1 - 1.4e-57 195.4 17.4 1.5e-57 195.3 17.4 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit DUF2935 PF11155.8 CCM03609.1 - 0.011 16.0 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Bindin PF02084.15 CCM03609.1 - 0.51 10.6 5.1 2.6 8.3 0.1 3.0 2 1 1 3 3 3 0 Bindin GMC_oxred_N PF00732.19 CCM03610.1 - 3.1e-41 141.7 0.0 4.7e-41 141.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM03610.1 - 8.6e-38 130.1 0.1 2.2e-37 128.8 0.0 1.7 2 0 0 2 2 2 1 GMC oxidoreductase Kelch_4 PF13418.6 CCM03611.1 - 3.4e-23 81.4 10.4 0.00012 22.0 0.2 5.9 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CCM03611.1 - 9.2e-17 60.6 4.7 0.001 19.0 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 CCM03611.1 - 8.2e-16 57.9 20.0 0.00017 21.8 0.2 7.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 CCM03611.1 - 5.7e-15 55.0 15.9 0.00031 20.9 0.1 6.0 3 2 2 5 5 5 4 Kelch motif Kelch_1 PF01344.25 CCM03611.1 - 1.4e-13 50.2 0.2 0.00058 19.4 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 CCM03611.1 - 1.4e-12 47.0 10.0 0.0034 17.3 0.1 6.1 6 0 0 6 6 6 5 Kelch motif ACBP PF00887.19 CCM03612.1 - 9.9e-23 80.2 0.0 1.3e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein PH PF00169.29 CCM03613.1 - 8.7e-30 103.3 0.0 7.2e-14 52.2 0.0 2.8 2 1 0 2 2 2 2 PH domain PH_11 PF15413.6 CCM03613.1 - 1.4e-08 35.1 7.6 0.00061 20.2 1.3 4.1 2 2 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 CCM03613.1 - 4.5e-06 26.8 0.0 0.0032 17.7 0.0 2.4 2 0 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.6 CCM03613.1 - 0.0007 19.7 0.0 0.51 10.5 0.0 3.8 4 1 0 4 4 4 1 PH domain PH_13 PF16652.5 CCM03613.1 - 0.0086 15.9 0.0 0.17 11.7 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 CCM03613.1 - 0.012 16.0 0.1 0.18 12.2 0.1 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain PH_2 PF08458.10 CCM03613.1 - 0.079 13.3 0.0 3 8.2 0.0 2.2 2 0 0 2 2 2 0 Plant pleckstrin homology-like region Mcp5_PH PF12814.7 CCM03613.1 - 0.16 12.1 1.5 33 4.6 0.0 3.3 3 1 0 3 3 3 0 Meiotic cell cortex C-terminal pleckstrin homology Rep_fac-A_C PF08646.10 CCM03614.1 - 3.9e-47 159.7 3.4 6.5e-46 155.7 0.6 2.5 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 CCM03614.1 - 3.1e-37 126.4 2.1 3.7e-37 126.2 0.7 1.9 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 CCM03614.1 - 2.8e-20 72.2 0.0 5.7e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 CCM03614.1 - 6.6e-12 45.2 2.6 1.2e-10 41.3 0.2 2.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain DUF5521 PF17659.1 CCM03614.1 - 0.0028 15.6 0.1 0.044 11.6 0.0 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5521) DUF223 PF02721.14 CCM03614.1 - 0.0041 17.4 3.5 0.0044 17.3 0.4 2.6 3 0 0 3 3 3 1 Domain of unknown function DUF223 DUF4539 PF15072.6 CCM03614.1 - 0.013 15.5 0.0 0.03 14.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) CDC24_OB3 PF17244.2 CCM03614.1 - 0.086 12.5 1.3 9.7 5.8 0.0 2.6 3 0 0 3 3 3 0 Cell division control protein 24, OB domain 3 Tim54 PF11711.8 CCM03615.1 - 2.4e-55 187.9 0.0 3.6e-55 187.3 0.0 1.3 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 TonB_N PF16031.5 CCM03616.1 - 0.24 11.9 7.1 0.79 10.2 3.2 2.5 2 0 0 2 2 2 0 TonB polyproline region Sec63 PF02889.16 CCM03617.1 - 7.6e-28 97.4 0.0 3.1e-26 92.1 0.0 2.3 1 1 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 CCM03617.1 - 8.4e-09 35.8 0.0 4.1e-08 33.5 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain Peptidase_M15_3 PF08291.11 CCM03617.1 - 0.096 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase M15 CKS PF01111.19 CCM03618.1 - 7.8e-36 122.2 0.2 1e-35 121.8 0.2 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit DUF3822 PF12864.7 CCM03618.1 - 0.022 13.9 0.0 0.023 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3822) Chorion_2 PF03964.15 CCM03618.1 - 0.1 13.4 1.3 0.16 12.8 1.3 1.3 1 0 0 1 1 1 0 Chorion family 2 CSN8_PSD8_EIF3K PF10075.9 CCM03620.1 - 8.2e-14 51.8 0.0 9.9e-13 48.3 0.0 2.2 2 1 0 2 2 2 1 CSN8/PSMD8/EIF3K family DUF1681 PF07933.14 CCM03621.1 - 2.1e-54 183.2 0.0 2.5e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Rab_eff_C PF04698.12 CCM03621.1 - 0.12 10.7 0.0 0.13 10.6 0.0 1.0 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus Pkinase PF00069.25 CCM03623.1 - 2.6e-39 135.2 0.0 6.4e-39 133.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03623.1 - 4.2e-13 49.2 0.0 6.3e-13 48.6 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM03623.1 - 0.0061 15.4 0.6 0.0086 14.9 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 CCM03623.1 - 0.068 12.8 0.4 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 CCM03623.1 - 0.076 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family NIF PF03031.18 CCM03624.1 - 2.8e-20 72.6 0.0 4.4e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 CCM03624.1 - 9.1e-07 28.5 0.0 2.7e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 CCM03624.1 - 0.053 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 STI1 domain NUDIX PF00293.28 CCM03625.1 - 8.8e-09 35.5 0.0 1.1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CCM03625.1 - 0.2 11.7 0.0 0.34 10.9 0.0 1.4 1 1 0 1 1 1 0 NUDIX domain COesterase PF00135.28 CCM03627.1 - 3.4e-62 211.0 0.0 4.4e-62 210.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM03627.1 - 1.3e-10 41.5 0.2 2.6e-10 40.5 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 CCM03627.1 - 0.015 14.2 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S9 PF00326.21 CCM03627.1 - 0.02 14.4 0.1 0.033 13.6 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Esterase PF00756.20 CCM03627.1 - 0.074 12.7 0.7 0.39 10.3 0.7 1.9 1 1 0 1 1 1 0 Putative esterase CwfJ_C_1 PF04677.15 CCM03628.1 - 5e-29 100.7 0.0 9.5e-29 99.8 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 zf-CCHC_2 PF13696.6 CCM03628.1 - 1.5e-28 98.2 18.4 6.4e-10 38.7 2.4 3.5 3 0 0 3 3 3 3 Zinc knuckle CwfJ_C_2 PF04676.14 CCM03628.1 - 2e-12 47.8 0.0 4e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 zf-CCHC PF00098.23 CCM03628.1 - 2.6e-10 39.9 12.1 6.9e-05 22.8 0.4 3.7 3 0 0 3 3 3 3 Zinc knuckle eIF3g PF12353.8 CCM03628.1 - 5.4e-05 23.6 10.8 0.69 10.3 0.5 3.3 2 1 1 3 3 3 3 Eukaryotic translation initiation factor 3 subunit G HIT PF01230.23 CCM03628.1 - 0.041 14.6 0.0 0.085 13.6 0.0 1.5 1 0 0 1 1 1 0 HIT domain DUF4428 PF14471.6 CCM03628.1 - 1.5 8.8 5.5 8.9 6.3 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) FYVE_2 PF02318.16 CCM03628.1 - 6.6 7.0 5.3 8.3 6.7 2.5 2.2 1 1 1 2 2 2 0 FYVE-type zinc finger zinc-ribbons_6 PF07191.12 CCM03628.1 - 6.6 6.8 10.1 13 5.8 3.8 2.7 1 1 1 2 2 2 0 zinc-ribbons zf-CCHC_3 PF13917.6 CCM03628.1 - 6.9 6.7 7.2 36 4.4 0.5 3.2 2 1 1 3 3 3 0 Zinc knuckle Na_trans_assoc PF06512.13 CCM03629.1 - 0.0014 19.0 10.2 0.0017 18.7 10.2 1.1 1 0 0 1 1 1 1 Sodium ion transport-associated ANAPC15 PF15243.6 CCM03629.1 - 0.015 15.7 6.6 0.015 15.7 6.6 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 15 PKI PF02827.16 CCM03629.1 - 0.24 11.6 7.5 2 8.7 0.1 2.6 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor TraF_2 PF13729.6 CCM03629.1 - 2.9 7.2 6.1 2.2 7.6 4.9 1.4 1 1 0 1 1 1 0 F plasmid transfer operon, TraF, protein Arginase PF00491.21 CCM03630.1 - 3.4e-77 259.7 0.0 4.3e-77 259.4 0.0 1.1 1 0 0 1 1 1 1 Arginase family HSP20 PF00011.21 CCM03631.1 - 3e-24 85.1 0.1 3.9e-24 84.7 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCM03631.1 - 3.2e-09 36.2 0.0 5e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 CCM03631.1 - 0.0029 18.6 0.0 0.004 18.1 0.0 1.2 1 0 0 1 1 1 1 CS domain BON PF04972.17 CCM03631.1 - 0.014 15.7 0.4 0.12 12.7 0.1 2.1 1 1 1 2 2 2 0 BON domain HMA PF00403.26 CCM03631.1 - 0.12 12.8 0.0 0.3 11.6 0.0 1.6 2 0 0 2 2 2 0 Heavy-metal-associated domain Zip PF02535.22 CCM03632.1 - 4.6 6.3 5.8 6.3 5.9 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 CCM03632.1 - 4.9 6.1 5.6 6.8 5.6 5.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 EF-hand_6 PF13405.6 CCM03633.1 - 7.2e-12 44.2 2.1 2.2e-06 27.2 0.2 3.3 2 1 1 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 CCM03633.1 - 6.7e-10 37.8 5.1 3e-06 26.4 0.1 3.6 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 CCM03633.1 - 3.2e-09 37.1 1.4 1.3e-07 32.0 0.8 2.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 CCM03633.1 - 1.6e-05 24.1 0.4 0.011 15.2 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CCM03633.1 - 0.0018 18.1 5.9 0.36 10.7 0.2 2.8 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 CCM03633.1 - 0.12 12.7 0.0 6.3 7.2 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain NIF PF03031.18 CCM03635.1 - 3.1e-09 36.8 0.0 5.4e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 CCM03635.1 - 1.7e-08 34.3 0.1 3.1e-08 33.5 0.1 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 CCM03635.1 - 8.2e-06 26.1 0.0 1.5e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CCM03635.1 - 0.00052 20.2 0.4 0.0028 17.9 0.1 2.2 1 1 1 2 2 2 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 CCM03635.1 - 0.13 12.7 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DUF5588 PF17826.1 CCM03635.1 - 0.17 10.7 0.5 0.27 10.1 0.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5588) BSP PF04450.12 CCM03636.1 - 1.7e-63 214.1 0.0 2e-63 214.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria SprT-like PF10263.9 CCM03636.1 - 0.00098 19.0 3.0 0.0022 17.8 3.0 1.7 1 1 0 1 1 1 1 SprT-like family Peptidase_M48 PF01435.18 CCM03636.1 - 0.084 12.6 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Peptidase family M48 Peptidase_M91 PF14891.6 CCM03636.1 - 0.18 12.1 0.0 0.24 11.7 0.0 1.2 1 0 0 1 1 1 0 Effector protein HLH PF00010.26 CCM03637.1 - 3.4e-08 33.3 0.0 5.3e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SNF2_N PF00176.23 CCM03639.1 - 1.8e-57 194.7 0.0 4e-54 183.6 0.0 2.3 3 0 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM03639.1 - 1.2e-16 61.0 0.0 2.8e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HIRAN PF08797.11 CCM03639.1 - 1.8e-10 40.6 0.0 5.6e-10 39.0 0.0 1.8 1 0 0 1 1 1 1 HIRAN domain Cpn60_TCP1 PF00118.24 CCM03640.1 - 7.2e-153 509.7 0.5 9e-153 509.4 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MFS_1 PF07690.16 CCM03641.1 - 7.6e-23 81.0 16.6 1.2e-22 80.4 16.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCM03642.1 - 6.2e-23 81.3 14.1 9.9e-23 80.6 14.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2631 PF10939.8 CCM03642.1 - 0.013 15.3 0.1 0.044 13.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2631) WLM PF08325.10 CCM03643.1 - 1.1e-56 192.0 0.0 2.8e-56 190.6 0.0 1.7 1 0 0 1 1 1 1 WLM domain Bot1p PF12298.8 CCM03643.1 - 3.8e-28 98.8 0.1 1e-27 97.4 0.1 1.8 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein DUF45 PF01863.17 CCM03643.1 - 0.0056 16.7 0.7 0.021 14.9 0.7 2.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 SVIP PF15811.5 CCM03643.1 - 0.02 15.3 0.1 0.02 15.3 0.1 4.5 5 0 0 5 5 5 0 Small VCP/p97-interacting protein Methyltransf_25 PF13649.6 CCM03644.1 - 3e-14 53.5 0.0 5.4e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM03644.1 - 5.3e-13 49.4 0.0 9.6e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM03644.1 - 3.7e-07 30.1 0.0 6.1e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM03644.1 - 1.1e-06 29.3 0.0 1.9e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM03644.1 - 2.5e-06 27.4 0.0 5.2e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM03644.1 - 3.3e-05 23.3 0.0 5.5e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CCM03644.1 - 0.00023 21.3 0.0 0.00039 20.6 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.15 CCM03644.1 - 0.026 14.4 0.0 0.12 12.2 0.0 1.9 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_29 PF03141.16 CCM03644.1 - 0.081 11.5 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.20 CCM03644.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Sas10_Utp3 PF04000.15 CCM03645.1 - 1e-14 54.9 0.0 1e-14 54.9 0.0 2.2 2 0 0 2 2 2 1 Sas10/Utp3/C1D family F-box-like PF12937.7 CCM03646.1 - 1e-06 28.5 2.2 6.5e-06 26.0 2.2 2.4 1 1 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CCM03646.1 - 9.7e-05 22.7 5.6 9.2 6.9 0.1 5.8 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCM03646.1 - 0.0078 16.2 7.3 1.2 9.3 0.1 5.8 6 0 0 6 6 6 1 Leucine Rich repeat F-box PF00646.33 CCM03646.1 - 0.0098 15.7 4.4 0.21 11.5 4.4 2.7 1 1 0 1 1 1 1 F-box domain YABBY PF04690.13 CCM03647.1 - 3.7e-08 34.1 0.1 3.9e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 YABBY protein FlgD PF03963.14 CCM03647.1 - 0.0014 18.9 0.2 0.0018 18.6 0.2 1.1 1 0 0 1 1 1 1 Flagellar hook capping protein - N-terminal region zf-RING_2 PF13639.6 CCM03648.1 - 1e-10 41.8 3.8 2.6e-10 40.5 3.8 1.8 1 0 0 1 1 1 1 Ring finger domain PA PF02225.22 CCM03648.1 - 6e-09 35.8 0.0 1.3e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-RING_11 PF17123.5 CCM03648.1 - 1e-08 34.7 2.7 1e-08 34.7 2.7 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CCM03648.1 - 6.9e-06 25.8 4.9 6.9e-06 25.8 4.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM03648.1 - 2.8e-05 24.0 1.8 5e-05 23.2 1.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCM03648.1 - 0.00012 21.9 3.0 0.00024 20.9 3.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM03648.1 - 0.0015 18.4 2.5 0.003 17.4 2.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCM03648.1 - 0.0023 18.2 6.1 0.0078 16.5 5.6 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CCM03648.1 - 0.063 13.3 3.9 0.18 11.9 0.5 2.6 2 0 0 2 2 2 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 CCM03648.1 - 0.065 13.3 2.2 0.23 11.6 2.2 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 CCM03648.1 - 0.068 12.8 4.5 0.14 11.8 4.5 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 CCM03648.1 - 0.1 12.5 3.7 0.25 11.3 3.1 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Sec1 PF00995.23 CCM03649.1 - 6e-113 379.1 0.0 6.9e-113 378.9 0.0 1.0 1 0 0 1 1 1 1 Sec1 family cNMP_binding PF00027.29 CCM03650.1 - 1.8e-28 98.4 0.0 6.2e-16 58.2 0.0 5.4 5 0 0 5 5 5 4 Cyclic nucleotide-binding domain Patatin PF01734.22 CCM03650.1 - 1.1e-17 64.9 2.6 3.5e-12 46.9 1.8 2.7 2 0 0 2 2 2 2 Patatin-like phospholipase Na_H_antiporter PF03553.14 CCM03650.1 - 0.024 13.9 0.4 0.045 13.0 0.4 1.3 1 0 0 1 1 1 0 Na+/H+ antiporter family Chitin_synth_1 PF01644.17 CCM03651.1 - 1.8e-70 236.1 0.2 2.7e-70 235.5 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCM03651.1 - 1.8e-25 88.7 0.0 6e-25 87.0 0.0 1.9 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCM03651.1 - 2.6e-25 89.1 0.4 6.2e-20 71.3 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCM03651.1 - 1.1e-07 32.0 0.2 1.1e-07 32.0 0.2 2.4 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CCM03651.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Pkinase PF00069.25 CCM03652.1 - 8.3e-24 84.4 0.0 1.2e-23 83.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03652.1 - 2.6e-12 46.6 0.0 3.7e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM03652.1 - 6.2e-09 35.1 0.0 1.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCM03652.1 - 0.013 15.4 0.0 0.044 13.7 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 CCM03652.1 - 0.1 11.5 0.1 0.16 11.0 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ICL PF00463.21 CCM03653.1 - 1.8e-187 624.0 0.0 2.1e-187 623.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 CCM03653.1 - 3.5e-09 36.5 0.0 1.3e-08 34.6 0.0 2.0 2 1 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Terpene_synth_C PF03936.16 CCM03654.1 - 7.8e-05 22.2 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain Homeodomain PF00046.29 CCM03656.1 - 7.5e-47 157.0 9.9 2.9e-15 55.8 0.2 3.3 3 0 0 3 3 3 3 Homeodomain Homeobox_KN PF05920.11 CCM03656.1 - 6.9e-14 51.5 3.1 3.3e-05 23.7 0.0 3.8 4 0 0 4 4 4 3 Homeobox KN domain HOCHOB PF17943.1 CCM03656.1 - 1.8e-07 31.9 0.0 0.09 13.5 0.0 3.2 3 0 0 3 3 3 3 Homeobox-cysteine loop-homeobox YdaS_antitoxin PF15943.5 CCM03656.1 - 4.6e-05 23.2 0.1 0.28 11.1 0.0 3.5 3 0 0 3 3 3 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Homez PF11569.8 CCM03656.1 - 0.011 15.1 0.1 11 5.6 0.0 3.2 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez HTH_3 PF01381.22 CCM03656.1 - 0.087 12.9 0.1 12 6.1 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix Fumble PF03630.14 CCM03657.1 - 8.7e-132 439.3 0.0 1.2e-131 438.9 0.0 1.2 1 0 0 1 1 1 1 Fumble Adaptin_N PF01602.20 CCM03658.1 - 1.9e-117 393.0 0.0 2.5e-117 392.6 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 CCM03658.1 - 4.1e-56 189.3 0.8 9.5e-56 188.1 0.8 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 CCM03658.1 - 5.8e-35 119.9 0.0 1.4e-34 118.6 0.0 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 CCM03658.1 - 6.2e-19 68.2 1.0 1.2e-10 41.6 0.0 5.9 3 1 3 6 6 6 3 HEAT repeats Cnd1 PF12717.7 CCM03658.1 - 1.2e-06 28.6 4.1 0.22 11.6 0.0 4.5 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CCM03658.1 - 0.012 15.8 5.2 8.7 6.9 0.1 5.9 6 0 0 6 6 6 0 HEAT repeat Arm PF00514.23 CCM03658.1 - 0.026 14.6 1.8 22 5.3 0.1 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.16 CCM03658.1 - 0.25 12.1 2.0 51 5.0 0.0 4.6 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Peptidase_M76 PF09768.9 CCM03659.1 - 3e-69 232.2 3.3 4.3e-69 231.7 3.3 1.2 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 CCM03659.1 - 0.71 9.8 3.8 1.5 8.7 3.2 1.8 1 1 0 1 1 1 0 SprT-like family WLM PF08325.10 CCM03659.1 - 2 8.5 4.0 1.1 9.3 0.3 2.0 2 0 0 2 2 2 0 WLM domain ECH_1 PF00378.20 CCM03660.1 - 2.3e-40 138.5 0.0 3.4e-40 137.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCM03660.1 - 1.1e-15 58.0 2.6 3.2e-14 53.2 0.4 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF2431 PF10354.9 CCM03661.1 - 2.6e-50 171.0 0.0 3.3e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Arrestin_N PF00339.29 CCM03661.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain RAMP4 PF06624.12 CCM03662.1 - 2.7e-16 59.4 0.0 3.1e-16 59.2 0.0 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 CAF1C_H4-bd PF12265.8 CCM03663.1 - 1.1e-28 99.3 0.9 3.4e-28 97.7 0.3 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CCM03663.1 - 1.5e-19 69.9 13.6 1.8e-05 25.4 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat INO80_Ies4 PF08193.11 CCM03664.1 - 0.0025 17.8 1.6 0.0025 17.8 1.6 3.8 2 2 1 4 4 4 1 INO80 complex subunit Ies4 PBP1_TM PF14812.6 CCM03664.1 - 0.0056 17.0 3.7 0.016 15.5 3.7 1.8 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 CCM03664.1 - 0.19 12.2 8.8 0.39 11.1 8.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain MPP6 PF10175.9 CCM03664.1 - 0.33 11.5 3.0 0.63 10.5 3.0 1.4 1 0 0 1 1 1 0 M-phase phosphoprotein 6 NOA36 PF06524.12 CCM03664.1 - 1.7 7.9 4.9 2.6 7.3 4.9 1.2 1 0 0 1 1 1 0 NOA36 protein Dopey_N PF04118.14 CCM03665.1 - 9.4e-111 369.8 3.6 6.3e-110 367.1 0.0 3.6 4 0 0 4 4 4 1 Dopey, N-terminal Cohesin_HEAT PF12765.7 CCM03665.1 - 0.026 14.8 0.8 0.26 11.6 0.2 3.1 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion EF-hand_6 PF13405.6 CCM03666.1 - 1.1e-09 37.4 0.2 0.00049 19.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 CCM03666.1 - 2.5e-07 31.0 0.8 2.5e-07 31.0 0.8 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 CCM03666.1 - 3.7e-07 29.3 0.2 0.001 18.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 CCM03666.1 - 3.6e-06 26.2 0.3 0.00085 18.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CCM03666.1 - 0.0038 17.0 0.2 0.061 13.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CCM03666.1 - 0.0058 16.9 0.3 0.67 10.3 0.3 2.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region ABC2_membrane PF01061.24 CCM03667.1 - 1.8e-61 207.2 54.2 2.1e-34 118.8 23.1 2.6 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 CCM03667.1 - 5.3e-33 114.4 0.0 5.3e-15 56.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCM03667.1 - 3.3e-20 71.8 1.5 4.2e-15 55.4 0.0 2.7 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CCM03667.1 - 6.1e-12 46.0 2.3 6.2e-12 46.0 0.1 2.2 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_18 PF13238.6 CCM03667.1 - 4e-06 27.4 0.0 0.011 16.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CCM03667.1 - 8.9e-06 25.9 0.2 0.087 13.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.6 CCM03667.1 - 0.00013 22.4 0.1 0.61 10.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CCM03667.1 - 0.00015 22.0 0.3 0.9 9.8 0.1 3.0 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CCM03667.1 - 0.00033 20.6 0.0 0.0047 16.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 CCM03667.1 - 0.00075 19.1 0.1 1.3 8.6 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 CCM03667.1 - 0.0014 18.5 0.0 0.06 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 CCM03667.1 - 0.0029 17.9 0.9 2 8.6 0.3 2.8 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 CCM03667.1 - 0.0059 17.0 1.7 0.78 10.1 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 CCM03667.1 - 0.023 14.4 0.3 0.21 11.3 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain SMC_N PF02463.19 CCM03667.1 - 0.027 13.9 0.2 0.64 9.4 0.0 2.9 4 0 0 4 4 4 0 RecF/RecN/SMC N terminal domain AAA PF00004.29 CCM03667.1 - 0.071 13.5 0.0 18 5.8 0.0 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CCM03667.1 - 0.072 12.8 0.0 4.2 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCM03667.1 - 0.15 11.6 0.0 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Prefoldin_2 PF01920.20 CCM03668.1 - 6.6e-16 58.2 6.0 9e-16 57.8 6.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Mei5 PF10376.9 CCM03668.1 - 0.0011 18.8 2.4 0.0014 18.6 2.4 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein Tropomyosin_1 PF12718.7 CCM03668.1 - 0.013 15.6 0.7 0.013 15.6 0.7 2.1 2 1 0 2 2 2 0 Tropomyosin like DHR10 PF18595.1 CCM03668.1 - 0.024 14.7 5.5 0.046 13.8 0.4 2.3 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain YojJ PF10372.9 CCM03668.1 - 0.038 14.1 1.5 0.72 10.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Calreticulin PF00262.18 CCM03669.1 - 2e-160 533.6 9.5 3.6e-160 532.8 9.5 1.4 1 0 0 1 1 1 1 Calreticulin family GTP_EFTU PF00009.27 CCM03669.1 - 1.7e-46 158.2 0.0 2.9e-46 157.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 CCM03669.1 - 6.5e-38 130.1 7.1 1.7e-37 128.7 7.1 1.8 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 CCM03669.1 - 7.1e-22 77.4 0.0 2.1e-21 75.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CCM03669.1 - 1.5e-21 76.2 0.0 3.8e-21 74.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CCM03669.1 - 1.6e-08 34.8 0.0 3.2e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CCM03669.1 - 1e-05 25.5 0.1 4.2e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CCM03669.1 - 1.1e-05 25.5 0.1 2e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CCM03669.1 - 0.027 13.9 0.1 0.066 12.6 0.1 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit OAD_gamma PF04277.13 CCM03669.1 - 0.1 13.2 0.1 0.26 11.9 0.1 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DSHCT PF08148.12 CCM03670.1 - 6e-46 156.1 0.3 1.2e-45 155.1 0.3 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 CCM03670.1 - 2.8e-31 109.4 0.0 4.1e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 rRNA-processing arch domain Ski2_N PF17911.1 CCM03670.1 - 6.6e-22 77.8 0.0 7.9e-19 67.8 0.1 2.4 1 1 1 2 2 2 2 Ski2 N-terminal region DEAD PF00270.29 CCM03670.1 - 1e-19 71.0 0.1 2.2e-19 69.9 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM03670.1 - 1.1e-06 28.9 0.0 2.9e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM03670.1 - 2.1e-06 27.9 0.0 4.2e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Methyltransf_23 PF13489.6 CCM03672.1 - 9e-06 25.6 0.0 0.036 13.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain FtsJ PF01728.19 CCM03672.1 - 0.0048 17.0 0.0 0.0078 16.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MFS_1 PF07690.16 CCM03673.1 - 8e-07 28.3 9.0 1e-06 28.0 9.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily SPESP1 PF15754.5 CCM03674.1 - 0.078 12.2 3.6 0.12 11.5 3.6 1.4 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 SH3_9 PF14604.6 CCM03675.1 - 1.1e-05 25.1 0.0 1.8e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCM03675.1 - 0.00042 19.9 0.0 0.00066 19.2 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCM03675.1 - 0.015 15.0 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Variant SH3 domain F-box PF00646.33 CCM03676.1 - 0.0013 18.5 0.9 0.0079 16.1 0.9 2.4 1 1 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCM03676.1 - 0.0052 16.7 0.4 0.025 14.5 0.1 2.2 2 0 0 2 2 2 1 F-box-like FYRN PF05964.14 CCM03678.1 - 2.6e-16 59.2 0.6 6.1e-16 58.0 0.6 1.7 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 CCM03678.1 - 3.1e-14 52.9 0.0 6.3e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus DUF573 PF04504.14 CCM03678.1 - 0.063 13.9 0.7 0.063 13.9 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF573 Ferritin PF00210.24 CCM03678.1 - 0.18 11.8 0.0 3.7 7.5 0.0 2.2 2 0 0 2 2 2 0 Ferritin-like domain SAGA-Tad1 PF12767.7 CCM03678.1 - 2.8 7.6 6.8 0.26 11.0 1.4 2.0 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit LEAP-2 PF07359.11 CCM03680.1 - 0.062 13.1 0.2 7.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) YTH PF04146.15 CCM03681.1 - 3.3e-63 212.6 0.0 1.5e-62 210.4 0.0 2.1 2 0 0 2 2 2 1 YT521-B-like domain RRM_1 PF00076.22 CCM03681.1 - 0.00035 20.3 0.0 0.11 12.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_fungal PF17667.1 CCM03682.1 - 6.5e-17 61.4 0.1 8.4e-17 61.0 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_fungal PF17667.1 CCM03683.1 - 3.9e-128 427.7 3.3 5.7e-65 219.7 0.2 2.2 2 0 0 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 CCM03683.1 - 5.4e-24 85.0 1.4 4.4e-11 42.7 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03683.1 - 1.9e-16 60.2 0.2 5.1e-07 29.2 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 CCM03683.1 - 4.5e-07 30.0 0.0 0.043 13.7 0.0 2.8 3 0 0 3 3 3 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM03683.1 - 2.2e-06 27.4 0.0 0.16 11.5 0.0 3.2 3 0 0 3 3 3 2 Choline/ethanolamine kinase RIO1 PF01163.22 CCM03683.1 - 1.6e-05 24.6 0.0 0.2 11.3 0.0 2.4 2 0 0 2 2 2 2 RIO1 family Kdo PF06293.14 CCM03683.1 - 1.6e-05 24.4 0.2 0.15 11.4 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1217 PF06748.12 CCM03683.1 - 0.0022 18.1 0.0 1.9 8.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1217) Haspin_kinase PF12330.8 CCM03683.1 - 0.055 12.4 0.1 5.6 5.8 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain DUF2835 PF11197.8 CCM03683.1 - 0.11 12.3 0.2 27 4.7 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2835) RICTOR_M PF14666.6 CCM03683.1 - 0.17 11.6 0.0 42 4.0 0.0 3.3 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain Ribosomal_L4 PF00573.22 CCM03683.1 - 0.25 11.0 0.0 0.25 11.0 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L4/L1 family MutS_V PF00488.21 CCM03684.1 - 3e-58 197.0 0.0 6.6e-58 195.8 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CCM03684.1 - 3e-35 122.2 0.6 8.9e-35 120.6 0.2 2.0 3 0 0 3 3 3 1 MutS domain III MutS_I PF01624.20 CCM03684.1 - 7.8e-23 80.9 0.0 1.7e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CCM03684.1 - 2.5e-10 40.8 0.0 8.9e-10 39.0 0.0 1.9 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CCM03684.1 - 1.4e-05 25.4 0.2 3.8e-05 24.0 0.2 1.7 1 0 0 1 1 1 1 MutS family domain IV BORA_N PF15280.6 CCM03684.1 - 0.0027 17.4 1.0 0.0051 16.5 1.0 1.4 1 0 0 1 1 1 1 Protein aurora borealis N-terminus SF-assemblin PF06705.11 CCM03684.1 - 0.1 12.0 0.1 0.24 10.7 0.1 1.6 1 0 0 1 1 1 0 SF-assemblin/beta giardin SH3_11 PF18103.1 CCM03684.1 - 0.16 12.1 0.0 0.51 10.6 0.0 1.8 1 0 0 1 1 1 0 Retroviral integrase C-terminal SH3 domain Cas9_REC PF16592.5 CCM03685.1 - 0.0013 17.6 0.0 0.0023 16.8 0.0 1.3 1 1 0 1 1 1 1 REC lobe of CRISPR-associated endonuclease Cas9 CAP_N PF01213.19 CCM03686.1 - 2.6e-106 355.7 0.0 3.5e-106 355.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 CCM03686.1 - 7.3e-59 197.9 2.1 9.8e-59 197.5 2.1 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 CCM03686.1 - 0.084 12.6 4.3 0.27 11.0 4.4 1.8 1 1 0 1 1 1 0 Tubulin binding cofactor C Gag_spuma PF03276.14 CCM03686.1 - 7.4 4.9 0.0 7.4 4.9 0.0 2.8 3 0 0 3 3 3 0 Spumavirus gag protein LETM1 PF07766.13 CCM03687.1 - 9e-103 343.3 0.3 9e-103 343.3 0.3 2.4 2 1 1 3 3 3 1 LETM1-like protein SAP PF02037.27 CCM03687.1 - 0.00076 19.2 0.2 0.012 15.3 0.0 3.0 3 0 0 3 3 3 1 SAP domain EF-hand_1 PF00036.32 CCM03687.1 - 0.0023 17.3 0.2 0.2 11.3 0.0 3.7 4 0 0 4 4 4 1 EF hand EF-hand_7 PF13499.6 CCM03687.1 - 0.0063 16.9 3.9 0.049 14.1 0.1 4.0 3 1 2 5 5 5 2 EF-hand domain pair EF-hand_6 PF13405.6 CCM03687.1 - 0.012 15.5 0.1 11 6.3 0.0 4.0 3 0 0 3 3 3 0 EF-hand domain ALMT PF11744.8 CCM03687.1 - 8.7 5.0 6.1 13 4.4 6.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter zf-RRN7 PF11781.8 CCM03689.1 - 0.0029 17.2 1.1 0.0056 16.3 1.1 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 CCM03689.1 - 0.023 14.2 1.7 0.05 13.1 1.7 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding TFIIB PF00382.19 CCM03689.1 - 0.039 14.0 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 Transcription factor TFIIB repeat HTH_7 PF02796.15 CCM03689.1 - 0.16 12.1 0.0 0.59 10.3 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_Tnp_4 PF13613.6 CCM03689.1 - 0.17 11.6 0.1 0.71 9.6 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease RF-1 PF00472.20 CCM03690.1 - 2.2e-22 79.2 2.0 6.1e-22 77.7 2.0 1.7 1 0 0 1 1 1 1 RF-1 domain Amidohydro_1 PF01979.20 CCM03690.1 - 2e-12 47.1 0.0 2.4e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 CCM03690.1 - 7.4e-12 45.5 0.2 0.00013 21.6 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family PD40 PF07676.12 CCM03690.1 - 4.3e-06 26.5 4.3 0.006 16.5 0.0 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Flavi_glycop_C PF02832.16 CCM03690.1 - 0.13 12.4 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Flavivirus glycoprotein, immunoglobulin-like domain DNA_pol_phi PF04931.13 CCM03691.1 - 4.7e-240 798.8 3.1 4.7e-240 798.8 3.1 1.9 2 0 0 2 2 2 1 DNA polymerase phi Nt_Gln_amidase PF09764.9 CCM03693.1 - 2.3e-33 115.4 0.0 3.4e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 N-terminal glutamine amidase Transferase PF02458.15 CCM03694.1 - 3.5e-30 105.0 0.0 4.2e-16 58.6 0.0 2.6 2 1 0 2 2 2 2 Transferase family Bac_export_1 PF01311.20 CCM03694.1 - 0.079 12.5 0.3 0.15 11.6 0.3 1.4 1 0 0 1 1 1 0 Bacterial export proteins, family 1 UQ_con PF00179.26 CCM03697.1 - 8.2e-36 122.7 0.2 2.7e-19 69.2 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme UEV PF05743.13 CCM03697.1 - 0.011 15.6 1.2 0.2 11.5 0.2 2.1 1 1 0 2 2 2 0 UEV domain Prok-E2_B PF14461.6 CCM03697.1 - 0.088 12.5 0.1 1.2 8.8 0.1 2.1 1 1 0 1 1 1 0 Prokaryotic E2 family B SPRY PF00622.28 CCM03698.1 - 7.7e-10 38.9 0.0 4.4e-07 30.0 0.0 3.0 3 0 0 3 3 3 2 SPRY domain PhoD PF09423.10 CCM03699.1 - 0.00011 21.4 0.0 0.09 11.8 0.0 2.3 2 0 0 2 2 2 2 PhoD-like phosphatase MutS_V PF00488.21 CCM03700.1 - 7.7e-44 150.0 0.2 2.3e-41 141.9 0.1 2.8 2 1 0 2 2 2 1 MutS domain V MutS_III PF05192.18 CCM03700.1 - 3.4e-30 105.7 2.5 3.4e-30 105.7 2.5 2.2 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 CCM03700.1 - 1.4e-07 31.7 0.1 1.2e-06 28.8 0.0 2.3 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 CCM03700.1 - 8.5e-06 26.1 0.3 3.1e-05 24.3 0.3 2.1 1 1 0 1 1 1 1 MutS domain II NatB_MDM20 PF09797.9 CCM03700.1 - 0.061 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit DAO PF01266.24 CCM03701.1 - 1.1e-33 117.2 2.6 1.6e-33 116.8 2.6 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCM03701.1 - 0.0039 16.4 0.1 0.0084 15.4 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CCM03701.1 - 0.005 16.0 0.2 0.02 14.0 0.2 1.9 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCM03701.1 - 0.0078 16.4 0.1 0.025 14.8 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM03701.1 - 0.028 13.6 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM03701.1 - 0.029 13.7 0.1 1.4 8.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCM03701.1 - 0.14 12.2 1.7 0.83 9.6 0.3 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding DUF3965 PF13112.6 CCM03701.1 - 0.15 11.3 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) DDE_Tnp_IS66_C PF13817.6 CCM03701.1 - 0.21 11.9 1.7 1.2 9.4 0.0 2.8 3 0 0 3 3 3 0 IS66 C-terminal element Amidase PF01425.21 CCM03702.1 - 1.8e-21 76.7 0.0 4.2e-14 52.4 0.0 2.0 2 0 0 2 2 2 2 Amidase Amidase PF01425.21 CCM03703.1 - 1.6e-30 106.5 0.0 2e-30 106.1 0.0 1.1 1 0 0 1 1 1 1 Amidase Ribosomal_S25 PF03297.15 CCM03704.1 - 6.9 6.9 6.4 19 5.5 6.4 1.7 1 0 0 1 1 1 0 S25 ribosomal protein PDZ_5 PF17817.1 CCM03705.1 - 0.092 13.0 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 PDZ domain RNA_pol_Rpb1_5 PF04998.17 CCM03706.1 - 5.4e-103 344.1 0.0 7.4e-103 343.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCM03706.1 - 7.1e-74 247.5 0.0 1.4e-73 246.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 CCM03706.1 - 2.1e-65 220.2 0.0 3.6e-65 219.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_1 PF04997.12 CCM03706.1 - 1.6e-58 198.5 0.0 2.4e-58 197.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_7 PF04990.12 CCM03706.1 - 5.3e-49 165.7 0.3 1.1e-48 164.6 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 CCM03706.1 - 2.6e-47 160.7 0.0 1.4e-46 158.3 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CCM03706.1 - 3.1e-34 117.2 0.0 6.4e-34 116.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 CCM03706.1 - 1e-06 28.7 200.6 0.025 14.9 10.6 13.6 10 1 2 13 13 13 9 RNA polymerase Rpb1 C-terminal repeat Na_K-ATPase PF00287.18 CCM03706.1 - 0.072 12.3 2.8 0.15 11.2 2.8 1.4 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain RNA_pol_Rpb1_1 PF04997.12 CCM03707.1 - 6.5e-34 117.7 0.1 7.6e-34 117.4 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 VHS PF00790.19 CCM03708.1 - 3.3e-44 150.2 0.0 3.9e-44 149.9 0.0 1.0 1 0 0 1 1 1 1 VHS domain Luteo_P1-P2 PF08467.10 CCM03708.1 - 0.087 12.1 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase UIM PF02809.20 CCM03709.1 - 9.4e-05 22.1 14.1 0.013 15.4 3.3 3.0 3 0 0 3 3 3 2 Ubiquitin interaction motif GAT PF03127.14 CCM03709.1 - 0.00044 20.5 0.2 0.00082 19.6 0.2 1.4 1 0 0 1 1 1 1 GAT domain DUF4743 PF15916.5 CCM03709.1 - 0.2 11.6 0.0 0.39 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4743) Joubert PF15392.6 CCM03709.1 - 2.5 7.7 7.6 0.59 9.8 3.7 1.9 2 1 0 2 2 2 0 Joubert syndrome-associated Vps35 PF03635.17 CCM03710.1 - 0 1020.9 0.4 0 1020.7 0.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Ribonuc_L-PSP PF01042.21 CCM03710.1 - 0.071 13.1 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Endoribonuclease L-PSP DUF202 PF02656.15 CCM03711.1 - 6.9e-20 71.3 0.6 7.9e-19 67.9 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Pro_dh PF01619.18 CCM03712.1 - 3.9e-56 190.8 0.0 1.9e-28 99.9 0.0 2.4 2 0 0 2 2 2 2 Proline dehydrogenase AP_endonuc_2 PF01261.24 CCM03712.1 - 0.013 15.0 0.0 0.14 11.6 0.0 2.4 2 1 0 3 3 3 0 Xylose isomerase-like TIM barrel BCIP PF13862.6 CCM03713.1 - 3e-64 216.6 0.0 3.6e-64 216.3 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein TIP120 PF08623.10 CCM03714.1 - 6.4e-58 195.2 2.9 1.7e-55 187.3 0.1 4.8 4 1 0 4 4 4 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 CCM03714.1 - 1.8e-16 58.8 18.3 0.065 13.5 0.0 13.2 15 0 0 15 15 13 2 HEAT repeat HEAT_EZ PF13513.6 CCM03714.1 - 3.5e-14 52.9 13.2 3.3 8.3 0.1 11.5 12 1 1 13 13 12 4 HEAT-like repeat Adaptin_N PF01602.20 CCM03714.1 - 2e-13 49.8 3.4 0.0094 14.6 0.0 5.9 3 2 1 5 5 5 4 Adaptin N terminal region HEAT_2 PF13646.6 CCM03714.1 - 1.9e-12 47.4 12.7 0.012 16.0 0.4 8.6 5 4 4 9 9 9 4 HEAT repeats Cnd1 PF12717.7 CCM03714.1 - 3.2e-12 46.8 9.9 0.13 12.3 0.3 7.8 7 4 3 10 10 10 3 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 CCM03714.1 - 5.3e-09 36.0 7.5 0.00082 19.0 0.1 5.6 5 1 1 6 6 6 2 CLASP N terminal DUF3385 PF11865.8 CCM03714.1 - 2.2e-07 30.9 3.4 0.01 15.8 0.0 5.6 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) Vac14_Fab1_bd PF12755.7 CCM03714.1 - 1.1e-05 25.9 4.6 5 7.8 0.0 6.4 7 2 2 9 9 7 1 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 CCM03714.1 - 1.6e-05 25.0 0.5 0.29 11.3 0.1 5.0 3 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 UME PF08064.13 CCM03714.1 - 0.00017 21.5 3.3 0.56 10.1 0.3 5.4 6 0 0 6 6 5 1 UME (NUC010) domain Cnd3 PF12719.7 CCM03714.1 - 0.00018 20.8 2.2 2.3 7.3 0.0 5.2 5 1 0 5 5 5 1 Nuclear condensing complex subunits, C-term domain Tti2 PF10521.9 CCM03714.1 - 0.00042 19.9 3.4 13 5.2 0.1 5.6 4 2 1 5 5 5 0 Tti2 family Telomere_reg-2 PF10193.9 CCM03714.1 - 0.0014 19.1 1.7 1.2 9.7 0.0 4.1 3 0 0 3 3 3 1 Telomere length regulation protein ParcG PF10274.9 CCM03714.1 - 0.0019 18.4 1.3 0.41 10.7 0.0 4.7 6 0 0 6 6 5 1 Parkin co-regulated protein MMS19_C PF12460.8 CCM03714.1 - 0.0025 17.0 22.5 0.11 11.5 0.1 5.3 3 3 1 5 5 5 2 RNAPII transcription regulator C-terminal V-ATPase_H_C PF11698.8 CCM03714.1 - 0.004 17.2 0.8 0.66 10.1 0.1 4.7 5 1 1 6 6 6 1 V-ATPase subunit H DUF3384 PF11864.8 CCM03714.1 - 0.013 14.4 3.3 0.036 13.0 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3384) TAF6_C PF07571.13 CCM03714.1 - 0.014 15.7 0.6 6.4 7.2 0.0 4.6 5 0 0 5 5 5 0 TAF6 C-terminal HEAT repeat domain Arm PF00514.23 CCM03714.1 - 0.026 14.6 4.1 15 5.8 0.0 6.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Sec5 PF15469.6 CCM03714.1 - 0.09 12.6 0.6 0.5 10.1 0.2 2.5 2 0 0 2 2 2 0 Exocyst complex component Sec5 FANCI_S2 PF14676.6 CCM03714.1 - 0.1 12.9 1.2 26 5.1 0.0 4.3 4 0 0 4 4 4 0 FANCI solenoid 2 Dopey_N PF04118.14 CCM03714.1 - 0.18 10.9 2.7 24 3.9 0.0 3.7 4 0 0 4 4 4 0 Dopey, N-terminal API5 PF05918.11 CCM03714.1 - 2.9 6.6 6.2 1.4 7.6 1.7 2.6 4 0 0 4 4 4 0 Apoptosis inhibitory protein 5 (API5) Sec7_N PF12783.7 CCM03714.1 - 4.8 7.1 7.6 20 5.0 0.2 4.9 5 2 1 6 6 6 0 Guanine nucleotide exchange factor in Golgi transport N-terminal AAA PF00004.29 CCM03715.1 - 5.1e-41 140.2 0.0 8.1e-41 139.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CCM03715.1 - 9.9e-27 92.7 0.1 3.2e-26 91.1 0.1 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 CCM03715.1 - 7.5e-23 80.4 7.9 1.9e-22 79.1 7.9 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 CCM03715.1 - 1.9e-07 30.7 0.0 1.1e-06 28.3 0.0 2.3 3 0 0 3 3 2 1 AAA+ lid domain AAA_16 PF13191.6 CCM03715.1 - 9.7e-07 29.3 0.2 1.8e-05 25.2 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CCM03715.1 - 1.1e-05 25.5 0.1 5.9e-05 23.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCM03715.1 - 1.3e-05 25.0 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCM03715.1 - 1.5e-05 25.3 1.6 0.024 14.9 0.0 2.8 2 1 1 3 3 3 2 AAA domain IstB_IS21 PF01695.17 CCM03715.1 - 4.5e-05 23.3 0.0 9.8e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 CCM03715.1 - 0.0002 21.4 0.1 0.00055 20.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.13 CCM03715.1 - 0.00028 20.2 0.0 0.0016 17.7 0.0 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CCM03715.1 - 0.0015 19.1 0.0 0.0037 17.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCM03715.1 - 0.0015 18.7 0.0 0.004 17.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 CCM03715.1 - 0.0016 17.8 0.2 0.0038 16.5 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_2 PF07724.14 CCM03715.1 - 0.002 18.3 0.1 0.0098 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 CCM03715.1 - 0.0027 17.3 0.3 0.56 9.7 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 CCM03715.1 - 0.003 17.3 0.0 0.012 15.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCM03715.1 - 0.0032 17.8 0.0 0.0096 16.3 0.0 1.9 1 0 0 1 1 1 1 RNA helicase ATPase PF06745.13 CCM03715.1 - 0.0084 15.5 0.1 2.7 7.2 0.0 2.4 1 1 1 2 2 2 1 KaiC TniB PF05621.11 CCM03715.1 - 0.011 15.2 0.0 1.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_17 PF13207.6 CCM03715.1 - 0.02 15.3 0.0 0.06 13.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CCM03715.1 - 0.045 13.1 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CCM03715.1 - 0.057 13.3 0.0 0.35 10.8 0.0 2.2 1 1 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.12 CCM03715.1 - 0.062 12.6 0.1 1.7 7.9 0.0 2.3 1 1 1 2 2 2 0 Zeta toxin Parvo_NS1 PF01057.17 CCM03715.1 - 0.071 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 CCM03715.1 - 0.092 12.9 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.16 CCM03715.1 - 0.1 12.0 1.5 0.17 11.3 0.2 2.1 2 1 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 CCM03715.1 - 0.1 12.1 0.0 0.42 10.1 0.0 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region TPR_1 PF00515.28 CCM03715.1 - 0.11 12.3 1.2 31 4.6 1.7 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ATPase_2 PF01637.18 CCM03715.1 - 0.25 11.2 3.5 2.5 7.9 0.0 2.7 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea TPR_2 PF07719.17 CCM03715.1 - 1.6 9.0 6.1 11 6.5 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat Pkinase PF00069.25 CCM03716.1 - 3e-52 177.6 0.0 4.2e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03716.1 - 6.5e-23 81.3 0.0 8.5e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM03716.1 - 0.00013 21.4 0.8 0.00042 19.7 0.2 1.9 2 1 0 2 2 2 1 Kinase-like FAD_binding_4 PF01565.23 CCM03716.1 - 0.13 12.0 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Kdo PF06293.14 CCM03716.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCM03716.1 - 0.13 11.9 0.1 9.5 5.8 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Ribosomal_L19e PF01280.20 CCM03717.1 - 7.3e-62 207.7 10.9 7.3e-62 207.7 10.9 1.7 2 0 0 2 2 2 1 Ribosomal protein L19e S4 PF01479.25 CCM03717.1 - 0.0088 15.7 0.0 0.043 13.5 0.0 2.1 2 0 0 2 2 2 1 S4 domain FAF PF11250.8 CCM03717.1 - 0.13 12.5 1.1 0.32 11.3 0.1 2.2 2 0 0 2 2 2 0 Fantastic Four meristem regulator PIEZO PF15917.5 CCM03717.1 - 5.2 6.5 8.4 4.2 6.8 7.4 1.4 1 1 0 1 1 1 0 Piezo MOZ_SAS PF01853.18 CCM03718.1 - 2.5e-63 212.9 0.0 1.9e-62 210.1 0.0 2.0 2 0 0 2 2 2 1 MOZ/SAS family zf-MYST PF17772.1 CCM03718.1 - 1e-18 66.7 1.5 2.1e-09 36.8 0.1 2.7 2 0 0 2 2 2 2 MYST family zinc finger domain Tudor-knot PF11717.8 CCM03718.1 - 2.6e-07 30.4 0.4 6.8e-07 29.1 0.4 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CCM03718.1 - 0.0016 18.8 0.0 0.0039 17.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM03718.1 - 0.0042 17.3 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Agenet PF05641.12 CCM03718.1 - 0.026 15.0 0.1 0.075 13.5 0.1 1.7 1 0 0 1 1 1 0 Agenet domain Pkinase PF00069.25 CCM03719.1 - 1.5e-33 116.3 0.0 2.1e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03719.1 - 1.1e-13 51.1 0.0 1.6e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM03719.1 - 0.023 14.0 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 CCM03719.1 - 0.13 12.2 5.1 0.96 9.3 0.5 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family F-box-like PF12937.7 CCM03720.1 - 9e-08 31.9 0.3 1.6e-07 31.1 0.3 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM03720.1 - 6.4e-06 25.9 0.1 1.1e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 F-box domain Pkinase_fungal PF17667.1 CCM03721.1 - 8.1e-21 74.3 0.0 2.2e-20 72.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 CCM03721.1 - 9.4e-11 41.6 0.0 1.3e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03721.1 - 1.9e-07 30.7 0.0 2.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM03721.1 - 0.001 19.1 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM03721.1 - 0.021 14.4 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 CCM03721.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM03721.1 - 0.095 12.3 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family adh_short PF00106.25 CCM03722.1 - 3.4e-17 62.5 0.0 5.8e-17 61.8 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM03722.1 - 9.3e-12 45.0 0.1 7.1e-11 42.1 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase p450 PF00067.22 CCM03723.1 - 2.1e-64 218.0 0.0 4.1e-63 213.7 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 PrsW-protease PF13367.6 CCM03723.1 - 0.035 13.5 0.0 7.4 6.0 0.0 2.6 2 0 0 2 2 2 0 PrsW family intramembrane metalloprotease DIOX_N PF14226.6 CCM03724.1 - 2.5e-24 86.3 0.0 1.4e-17 64.5 0.0 2.2 2 0 0 2 2 2 2 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM03724.1 - 2.1e-21 76.3 0.0 3.3e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GPI-anchored PF10342.9 CCM03725.1 - 0.016 15.9 0.2 0.022 15.5 0.2 1.1 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family AAA PF00004.29 CCM03726.1 - 1.4e-38 132.3 0.0 2.6e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCM03726.1 - 6.2e-11 41.9 0.1 2.1e-10 40.2 0.1 1.9 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 CCM03726.1 - 1.8e-07 31.1 0.0 4.4e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CCM03726.1 - 9e-06 25.9 0.0 1.7e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CCM03726.1 - 9.4e-06 26.1 0.2 0.00088 19.7 0.0 2.5 1 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CCM03726.1 - 2.2e-05 24.5 0.0 4.7e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCM03726.1 - 3.2e-05 24.2 0.2 0.0028 17.9 0.0 2.7 1 1 2 3 3 3 1 AAA domain AAA_5 PF07728.14 CCM03726.1 - 6.7e-05 22.9 0.4 0.0012 18.9 0.4 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCM03726.1 - 8.2e-05 23.2 0.0 0.00016 22.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 CCM03726.1 - 0.00031 20.7 0.1 0.00093 19.2 0.0 1.7 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_33 PF13671.6 CCM03726.1 - 0.00034 20.8 0.0 0.00063 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CCM03726.1 - 0.00057 19.7 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CCM03726.1 - 0.0008 18.8 0.3 0.0018 17.7 0.3 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CCM03726.1 - 0.001 19.3 0.0 0.0027 18.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain TniB PF05621.11 CCM03726.1 - 0.002 17.6 0.1 1.9 7.9 0.0 2.7 2 1 1 3 3 3 1 Bacterial TniB protein TIP49 PF06068.13 CCM03726.1 - 0.0023 17.2 0.2 0.0043 16.3 0.0 1.5 2 0 0 2 2 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 CCM03726.1 - 0.0027 18.1 0.0 0.0055 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Sigma54_activ_2 PF14532.6 CCM03726.1 - 0.0071 16.5 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_25 PF13481.6 CCM03726.1 - 0.0073 15.9 0.1 0.16 11.6 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CCM03726.1 - 0.0098 16.3 0.1 0.03 14.8 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 CCM03726.1 - 0.01 15.6 0.0 0.021 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCM03726.1 - 0.011 16.2 0.0 0.023 15.2 0.0 1.7 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CCM03726.1 - 0.013 15.0 0.1 0.046 13.2 0.0 2.0 2 1 0 2 2 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 CCM03726.1 - 0.013 14.7 0.1 0.025 13.9 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 CCM03726.1 - 0.018 15.0 0.1 0.045 13.7 0.1 1.7 1 0 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.18 CCM03726.1 - 0.02 14.6 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_21 PF13304.6 CCM03726.1 - 0.024 14.5 0.1 0.55 10.0 0.0 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Bac_DnaA PF00308.18 CCM03726.1 - 0.026 14.4 0.0 0.07 13.0 0.0 1.7 1 1 0 1 1 1 0 Bacterial dnaA protein TsaE PF02367.17 CCM03726.1 - 0.035 14.1 0.0 0.081 12.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE tRNA_lig_kinase PF08303.11 CCM03726.1 - 0.048 13.8 0.0 0.09 12.9 0.0 1.4 1 0 0 1 1 1 0 tRNA ligase kinase domain Hydin_ADK PF17213.3 CCM03726.1 - 0.049 13.9 0.5 0.48 10.7 0.0 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain ATPase PF06745.13 CCM03726.1 - 0.074 12.4 0.1 2 7.7 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_3 PF07726.11 CCM03726.1 - 0.09 12.6 0.0 0.16 11.8 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CCM03726.1 - 0.093 11.9 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CCM03726.1 - 0.1 12.3 0.0 0.25 11.0 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 CCM03726.1 - 0.13 12.2 0.0 0.81 9.6 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea SKI PF01202.22 CCM03726.1 - 0.13 12.4 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 Shikimate kinase Parvo_NS1 PF01057.17 CCM03726.1 - 0.14 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PduV-EutP PF10662.9 CCM03726.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Guanylate_kin PF00625.21 CCM03726.1 - 0.19 11.4 0.0 0.75 9.5 0.0 2.1 3 0 0 3 3 1 0 Guanylate kinase Trehalase PF01204.18 CCM03727.1 - 3.9e-112 375.7 4.5 4.9e-100 335.8 0.1 2.1 2 0 0 2 2 2 2 Trehalase GDE_C PF06202.14 CCM03727.1 - 0.006 15.6 0.1 0.022 13.7 0.1 1.8 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase RRM_1 PF00076.22 CCM03728.1 - 2.7e-08 33.5 0.0 7.6e-08 32.1 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 CCM03728.1 - 7.6e-07 29.4 0.9 1.2e-06 28.7 0.2 1.7 2 0 0 2 2 2 1 PWI domain Sad1_UNC PF07738.13 CCM03729.1 - 3.1e-28 98.4 0.0 5.4e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal ATP-synt_C PF00137.21 CCM03730.1 - 6.6e-35 119.3 34.5 6.3e-22 77.7 15.4 2.3 2 0 0 2 2 2 2 ATP synthase subunit C Pyr_redox_2 PF07992.14 CCM03731.1 - 1.9e-50 171.8 0.0 2.3e-50 171.5 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM03731.1 - 4.2e-17 62.4 0.1 3.3e-13 49.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM03731.1 - 2.3e-16 60.1 0.3 1.9e-13 50.8 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM03731.1 - 1.9e-06 27.3 0.1 5.3e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 CCM03731.1 - 1.4e-05 24.4 1.9 0.005 16.0 0.1 3.4 4 0 0 4 4 4 1 Glucose inhibited division protein A DAO PF01266.24 CCM03731.1 - 2.9e-05 23.8 0.0 8.9e-05 22.2 0.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM03731.1 - 3.6e-05 23.0 1.6 0.0032 16.6 0.1 2.5 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.6 CCM03731.1 - 8.1e-05 22.8 0.4 0.0044 17.2 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CCM03731.1 - 0.00083 18.8 0.0 0.0071 15.7 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CCM03731.1 - 0.0013 19.1 0.0 0.097 13.1 0.0 2.7 2 1 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 CCM03731.1 - 0.0016 17.8 0.2 0.034 13.4 0.0 2.4 2 1 1 3 3 3 1 FAD binding domain K_oxygenase PF13434.6 CCM03731.1 - 0.0043 16.2 0.1 0.53 9.4 0.0 3.2 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CCM03731.1 - 0.0059 15.4 0.9 0.042 12.5 0.1 2.5 3 0 0 3 3 3 1 HI0933-like protein Shikimate_DH PF01488.20 CCM03731.1 - 0.0065 16.5 0.2 8.8 6.4 0.0 3.1 4 0 0 4 4 4 2 Shikimate / quinate 5-dehydrogenase Trp_halogenase PF04820.14 CCM03731.1 - 0.012 14.4 0.8 0.064 12.1 0.2 2.3 2 1 1 3 3 3 0 Tryptophan halogenase ApbA PF02558.16 CCM03731.1 - 0.05 13.2 0.7 15 5.2 0.0 3.0 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CCM03731.1 - 0.055 14.0 0.0 2.7 8.6 0.0 2.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Tetraspanin PF00335.20 CCM03732.1 - 5.8e-12 45.8 6.1 8.6e-12 45.2 6.1 1.2 1 0 0 1 1 1 1 Tetraspanin family 5TM-5TMR_LYT PF07694.12 CCM03732.1 - 8.7 5.8 12.8 5.9 6.4 5.8 2.7 2 1 1 3 3 3 0 5TMR of 5TMR-LYT RicinB_lectin_2 PF14200.6 CCM03734.1 - 1.3e-08 35.4 7.7 7.4e-07 29.8 1.7 2.1 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Cactin_mid PF10312.9 CCM03734.1 - 0.094 12.4 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Conserved mid region of cactin ALG11_N PF15924.5 CCM03735.1 - 2.1e-88 295.9 0.3 2.8e-88 295.4 0.3 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 CCM03735.1 - 3.6e-24 85.2 0.0 6.1e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCM03735.1 - 2e-12 47.7 0.0 3.9e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 TMEM37 PF15108.6 CCM03735.1 - 0.11 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family FTR1 PF03239.14 CCM03735.1 - 0.16 11.1 0.2 1.8 7.7 0.0 2.3 2 1 1 3 3 3 0 Iron permease FTR1 family FMN_dh PF01070.18 CCM03736.1 - 5.1e-111 371.1 0.0 6.8e-111 370.7 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CCM03736.1 - 4.7e-05 22.6 0.1 0.00028 20.0 0.0 2.2 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CCM03736.1 - 7.5e-05 22.0 0.0 0.00012 21.4 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 CCM03736.1 - 0.00011 21.6 0.0 0.35 10.1 0.0 3.1 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG NFACT-R_1 PF05670.13 CCM03737.1 - 1.3e-35 122.3 0.0 2.7e-35 121.3 0.0 1.5 1 0 0 1 1 1 1 NFACT protein RNA binding domain NOT2_3_5 PF04153.18 CCM03738.1 - 4.6e-29 101.2 0.2 4.6e-29 101.2 0.2 2.2 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family RNA_pol_Rpb4 PF03874.16 CCM03739.1 - 6.2e-24 84.7 2.1 8.8e-24 84.2 2.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 DED PF01335.21 CCM03739.1 - 0.065 13.5 0.1 0.27 11.5 0.0 2.0 2 0 0 2 2 2 0 Death effector domain ENTH PF01417.20 CCM03741.1 - 2.2e-41 140.8 0.0 3.7e-41 140.1 0.0 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 CCM03741.1 - 0.085 11.8 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 ANTH domain Glyco_hydro_20 PF00728.22 CCM03742.1 - 5.3e-82 276.0 0.0 6.5e-82 275.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 CCM03742.1 - 6e-15 56.1 0.0 9.6e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 CCM03742.1 - 9.7e-06 26.4 0.1 3.7e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 TMF_TATA_bd PF12325.8 CCM03743.1 - 0.00086 19.5 11.2 0.00086 19.5 11.2 15.8 6 4 7 15 15 15 1 TATA element modulatory factor 1 TATA binding CCT_2 PF09425.10 CCM03743.1 - 0.16 11.8 0.6 0.52 10.2 0.6 1.9 1 0 0 1 1 1 0 Divergent CCT motif DUF3660 PF12398.8 CCM03743.1 - 0.96 9.6 4.5 1.5 8.9 2.6 2.5 1 1 0 1 1 1 0 Receptor serine/threonine kinase MTA_R1 PF17226.2 CCM03743.1 - 1.5 9.0 5.5 0.77 9.9 0.4 3.4 3 0 0 3 3 3 0 MTA R1 domain Lgl_C PF08596.10 CCM03744.1 - 2e-16 59.7 0.0 2.5e-11 42.9 0.0 2.4 2 0 0 2 2 2 2 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 CCM03744.1 - 9.4e-05 23.1 10.9 0.0094 16.8 0.1 6.1 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03744.1 - 0.00015 22.0 0.0 0.024 15.0 0.0 3.5 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUF287 PF03384.14 CCM03744.1 - 0.03 14.7 0.1 0.062 13.7 0.1 1.4 1 0 0 1 1 1 0 Drosophila protein of unknown function, DUF287 Synaptobrevin PF00957.21 CCM03745.1 - 0.018 14.8 0.1 0.024 14.4 0.1 1.2 1 0 0 1 1 1 0 Synaptobrevin SnoaL_2 PF12680.7 CCM03746.1 - 0.0013 19.4 0.0 0.002 18.7 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain DUF2358 PF10184.9 CCM03746.1 - 0.067 13.5 0.0 0.099 12.9 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) Asp PF00026.23 CCM03747.1 - 8.6e-45 153.5 18.3 2.9e-44 151.8 18.3 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CCM03747.1 - 4.2e-06 27.3 7.0 4.6e-05 24.0 2.1 3.1 3 0 0 3 3 3 1 Aspartyl protease TAXi_N PF14543.6 CCM03747.1 - 8.6e-06 26.1 6.8 0.017 15.4 1.2 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 CCM03747.1 - 0.031 14.8 4.6 0.09 13.4 0.3 2.7 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease zf-RING_2 PF13639.6 CCM03748.1 - 2.3e-11 43.9 5.0 2.3e-11 43.9 5.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 CCM03748.1 - 4.1e-10 39.8 4.1 4.1e-10 39.8 4.1 1.7 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CCM03748.1 - 5.6e-07 29.3 7.2 5.6e-07 29.3 7.2 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM03748.1 - 8.3e-07 28.9 2.2 8.3e-07 28.9 2.2 2.5 2 2 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CCM03748.1 - 1.6e-06 27.9 2.9 1.6e-06 27.9 2.9 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCM03748.1 - 2.1e-06 27.5 4.5 2.1e-06 27.5 4.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCM03748.1 - 3.5e-06 27.0 0.3 7e-06 26.0 0.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCM03748.1 - 2e-05 24.2 3.9 6.3e-05 22.6 3.9 1.9 1 1 0 1 1 1 1 RING-like zinc finger zinc_ribbon_9 PF14369.6 CCM03748.1 - 0.00014 22.1 5.3 0.00014 22.0 2.3 2.4 2 0 0 2 2 2 1 zinc-ribbon zf-C3HC4_3 PF13920.6 CCM03748.1 - 0.00022 21.0 9.5 0.00032 20.5 2.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCM03748.1 - 0.001 18.8 4.7 0.001 18.8 4.7 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 CCM03748.1 - 0.018 15.2 4.2 0.1 12.8 4.2 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain HypA PF01155.19 CCM03748.1 - 0.16 12.0 5.1 3.6 7.6 0.5 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYVE_2 PF02318.16 CCM03748.1 - 0.79 9.9 3.0 5.9 7.1 0.2 2.3 2 0 0 2 2 2 0 FYVE-type zinc finger DZR PF12773.7 CCM03748.1 - 0.81 9.8 7.8 6 7.0 0.4 3.0 2 1 1 3 3 3 0 Double zinc ribbon PHD PF00628.29 CCM03748.1 - 1.2 9.1 14.9 0.29 11.0 3.9 2.7 3 0 0 3 3 3 0 PHD-finger RINGv PF12906.7 CCM03748.1 - 6.7 6.9 7.7 2.3 8.4 1.6 2.4 2 1 0 2 2 2 0 RING-variant domain Zn_ribbon_17 PF17120.5 CCM03748.1 - 6.9 6.4 9.8 0.28 10.8 3.3 2.0 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Aldedh PF00171.22 CCM03749.1 - 1.5e-117 392.9 0.0 1.9e-117 392.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribonuclease_T2 PF00445.18 CCM03749.1 - 1.4e-36 126.4 4.1 2.8e-36 125.4 4.1 1.4 1 0 0 1 1 1 1 Ribonuclease T2 family LuxC PF05893.14 CCM03749.1 - 0.29 10.1 0.4 0.96 8.4 0.4 1.7 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF89 PF01937.19 CCM03750.1 - 1.2e-111 373.1 0.1 1.5e-111 372.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 WD40 PF00400.32 CCM03751.1 - 4.5e-58 191.9 20.4 2e-06 28.4 0.1 11.7 12 0 0 12 12 12 10 WD domain, G-beta repeat Utp13 PF08625.11 CCM03751.1 - 5.9e-45 152.7 0.0 9.2e-45 152.0 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 CCM03751.1 - 1.3e-07 31.8 2.6 2.5 8.5 0.0 7.2 5 2 3 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCM03751.1 - 7.9e-06 24.8 3.5 4.7 5.7 0.1 4.9 4 1 1 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 CCM03751.1 - 0.00077 18.9 1.2 0.0043 16.4 0.0 2.8 4 0 0 4 4 4 1 WD40-like domain Mcl1_mid PF12341.8 CCM03751.1 - 0.0037 16.7 0.0 0.44 9.9 0.0 2.7 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region VID27 PF08553.10 CCM03751.1 - 0.024 13.7 0.0 0.058 12.4 0.0 1.6 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Forkhead PF00250.18 CCM03752.1 - 1.2e-17 63.9 0.0 4.1e-08 33.4 0.0 2.3 2 0 0 2 2 2 2 Forkhead domain Bradykinin PF06753.12 CCM03752.1 - 0.057 13.1 0.4 0.057 13.1 0.4 3.6 3 0 0 3 3 3 0 Bradykinin NIPSNAP PF07978.13 CCM03753.1 - 2.9e-32 110.9 0.8 2.6e-25 88.6 0.2 2.2 2 0 0 2 2 2 2 NIPSNAP Mob_synth_C PF06463.13 CCM03755.1 - 2.2e-38 131.1 0.0 4.9e-38 130.0 0.0 1.6 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 CCM03755.1 - 1.1e-29 104.0 0.0 3.3e-29 102.4 0.0 1.8 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 CCM03755.1 - 2.2e-06 28.0 0.0 7.2e-06 26.3 0.0 1.8 3 0 0 3 3 3 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CCM03755.1 - 0.0087 16.2 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain MoaC PF01967.21 CCM03756.1 - 9.1e-48 161.8 0.0 1.6e-47 161.0 0.0 1.4 1 1 0 1 1 1 1 MoaC family FR47 PF08445.10 CCM03757.1 - 3.6e-07 30.0 0.0 6.5e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 CCM03757.1 - 1.8e-06 27.9 0.0 2.9e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM03757.1 - 5.3e-06 26.7 0.0 9.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCM03757.1 - 3.9e-05 24.0 0.0 7.5e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCM03757.1 - 0.11 12.6 0.0 0.32 11.1 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain polyprenyl_synt PF00348.17 CCM03760.1 - 4e-62 209.6 0.0 2.3e-57 194.0 0.0 2.1 2 0 0 2 2 2 2 Polyprenyl synthetase HTH_17 PF12728.7 CCM03761.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CCM03761.1 - 0.19 11.6 0.2 0.37 10.7 0.2 1.4 1 0 0 1 1 1 0 Homeodomain-like domain CAF-1_p150 PF11600.8 CCM03762.1 - 1.5 8.5 25.6 2.3 7.9 25.6 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SIKE PF05769.11 CCM03763.1 - 4e-07 30.1 15.9 1.8e-05 24.8 7.0 2.5 1 1 0 2 2 2 2 SIKE family PikAIV_N PF18605.1 CCM03763.1 - 0.33 10.6 4.8 5.2 6.7 1.4 3.2 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain NCBP3 PF10309.9 CCM03764.1 - 2.8e-08 33.5 0.0 7.7e-08 32.1 0.0 1.7 2 0 0 2 2 2 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 CCM03764.1 - 0.00045 20.2 0.0 0.00086 19.3 0.0 1.4 1 0 0 1 1 1 1 RNA binding domain UBM PF14377.6 CCM03764.1 - 0.023 14.2 0.2 0.041 13.3 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin binding region WD40 PF00400.32 CCM03768.1 - 1.3e-33 114.5 17.7 1.2e-06 29.2 0.0 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03768.1 - 1.2e-12 48.0 0.1 0.015 15.6 0.1 5.8 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Tropomyosin PF00261.20 CCM03768.1 - 0.002 17.6 47.8 0.002 17.6 47.8 6.7 1 1 6 7 7 7 2 Tropomyosin Ge1_WD40 PF16529.5 CCM03768.1 - 0.0031 16.5 0.2 2 7.3 0.0 3.6 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCM03768.1 - 0.018 14.4 0.0 0.67 9.2 0.0 2.6 2 1 1 3 3 3 0 WD40-like domain eIF2A PF08662.11 CCM03768.1 - 0.033 14.0 0.0 1.4 8.7 0.0 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A SlyX PF04102.12 CCM03768.1 - 0.034 14.8 0.1 0.034 14.8 0.1 10.0 6 2 4 10 10 10 0 SlyX Spc7 PF08317.11 CCM03768.1 - 0.2 10.5 109.4 0.057 12.3 17.4 5.9 1 1 5 6 6 6 0 Spc7 kinetochore protein PKcGMP_CC PF16808.5 CCM03768.1 - 6.8 6.6 19.3 37 4.3 0.0 7.4 6 1 1 7 7 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase dsrm PF00035.26 CCM03769.1 - 3.7e-11 43.6 0.0 4.2e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Double-stranded RNA binding motif dsrm PF00035.26 CCM03770.1 - 3e-07 31.0 0.0 3.5e-07 30.8 0.0 1.0 1 0 0 1 1 1 1 Double-stranded RNA binding motif UCH PF00443.29 CCM03771.1 - 7.7e-26 91.1 0.0 1.1e-25 90.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CCM03771.1 - 2.1e-11 44.0 0.1 4.1e-11 43.0 0.1 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein PCI PF01399.27 CCM03772.1 - 3.5e-21 75.7 0.8 9.2e-21 74.3 0.8 1.8 1 0 0 1 1 1 1 PCI domain DUF3626 PF12294.8 CCM03772.1 - 0.02 13.9 0.0 0.042 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3626) DUF5517 PF17639.2 CCM03772.1 - 1.4 9.2 5.0 1.1 9.6 0.4 3.0 3 1 0 3 3 3 0 Family of unknown function (DUF5517) MRP-L28 PF09812.9 CCM03773.1 - 0.0019 18.3 0.1 0.081 13.1 0.2 2.3 2 0 0 2 2 2 2 Mitochondrial ribosomal protein L28 Ribosomal_L1 PF00687.21 CCM03774.1 - 7.8e-22 78.0 0.0 1.7e-21 76.9 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Rsm22 PF09243.10 CCM03775.1 - 3.7e-44 151.1 0.0 3.6e-29 101.9 0.0 3.1 2 1 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 Bromodomain PF00439.25 CCM03776.1 - 6.6e-57 189.6 0.0 5.1e-19 68.1 0.0 3.6 3 0 0 3 3 3 3 Bromodomain Peptidase_M1 PF01433.20 CCM03776.1 - 1.1e-06 28.4 0.0 1.6e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain HEAT_2 PF13646.6 CCM03776.1 - 0.093 13.1 4.8 10 6.6 0.0 4.0 4 0 0 4 4 4 0 HEAT repeats Peptidase_M1_N PF17900.1 CCM03776.1 - 0.14 12.4 0.5 8.6 6.5 0.1 2.5 2 0 0 2 2 2 0 Peptidase M1 N-terminal domain UCH PF00443.29 CCM03777.1 - 0.00025 20.6 0.2 0.00067 19.2 0.2 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 CCM03777.1 - 0.00083 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain H-kinase_dim PF02895.14 CCM03777.1 - 0.032 14.6 1.0 5.5 7.5 0.2 3.4 3 0 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain Syntaxin-6_N PF09177.11 CCM03777.1 - 0.064 13.8 0.2 0.22 12.1 0.2 1.9 1 0 0 1 1 1 0 Syntaxin 6, N-terminal HSCB_C PF07743.13 CCM03777.1 - 0.76 10.3 4.5 0.77 10.3 0.9 2.7 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain LTV PF04180.14 CCM03778.1 - 3.5e-102 343.0 0.2 7.9e-94 315.5 2.3 2.1 1 1 1 2 2 2 2 Low temperature viability protein PIP5K PF01504.18 CCM03779.1 - 1.4e-44 152.4 0.3 3.5e-36 124.9 0.3 2.5 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 CCM03779.1 - 3.6e-27 95.2 0.0 5.6e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 CCM03779.1 - 3.2e-16 59.2 11.6 3.2e-16 59.2 11.6 2.0 2 0 0 2 2 2 1 FYVE zinc finger DUF3410 PF11890.8 CCM03779.1 - 0.023 14.5 5.5 0.29 11.0 2.2 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF3410) Zf_RING PF16744.5 CCM03779.1 - 2.3 8.4 5.8 6 7.1 5.8 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger IBR PF01485.21 CCM03779.1 - 5.8 7.2 12.0 0.39 11.0 5.6 2.2 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Med11 PF10280.9 CCM03780.1 - 1.4e-09 38.5 0.0 1.7e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Mediator complex protein TBCA PF02970.16 CCM03781.1 - 2e-20 72.9 3.5 2e-20 72.9 3.5 1.8 1 1 1 2 2 2 1 Tubulin binding cofactor A NTP_transf_6 PF06042.11 CCM03781.1 - 0.13 12.2 2.9 0.3 10.9 0.6 2.0 1 1 1 2 2 2 0 Nucleotidyltransferase KfrA_N PF11740.8 CCM03781.1 - 0.18 12.5 5.4 1.4 9.7 5.4 2.0 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term HLH PF00010.26 CCM03782.1 - 2.2e-09 37.2 2.4 2.2e-09 37.2 2.4 2.7 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain UPF0242 PF06785.11 CCM03782.1 - 0.069 13.2 2.5 0.092 12.8 2.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ribosomal_60s PF00428.19 CCM03782.1 - 0.11 13.1 5.0 0.97 10.1 1.5 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Mtp PF03821.16 CCM03784.1 - 0.064 12.8 0.2 0.094 12.3 0.2 1.2 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter HLH PF00010.26 CCM03785.1 - 1.7e-11 43.9 2.4 1.8e-11 43.8 1.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain ATG27 PF09451.10 CCM03786.1 - 1.5e-09 38.1 0.0 1.9e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 CCM03786.1 - 3.7e-08 32.8 0.0 4.2e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 CCM03786.1 - 0.0001 22.4 0.0 0.00014 21.9 0.0 1.2 1 0 0 1 1 1 1 Cation-independent mannose-6-phosphate receptor repeat Complex1_49kDa PF00346.19 CCM03787.1 - 3.7e-110 367.3 0.0 6.4e-110 366.5 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 CCM03787.1 - 0.0043 16.0 0.0 0.0061 15.5 0.0 1.4 1 0 0 1 1 1 1 Nickel-dependent hydrogenase NIF3 PF01784.18 CCM03788.1 - 6.9e-68 228.9 0.0 8.3e-68 228.6 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) NTP_transf_3 PF12804.7 CCM03788.1 - 0.055 13.8 0.1 0.099 13.0 0.1 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain Glutaredoxin PF00462.24 CCM03789.1 - 5.2e-17 61.8 0.0 7.5e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 CCM03789.1 - 0.00012 22.5 0.0 0.00028 21.3 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 CCM03789.1 - 0.00092 19.2 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_4 PF13462.6 CCM03789.1 - 0.016 15.4 0.1 5 7.3 0.1 2.2 2 0 0 2 2 2 0 Thioredoxin DUF836 PF05768.14 CCM03789.1 - 0.016 15.6 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) GST_N_3 PF13417.6 CCM03789.1 - 0.047 14.1 0.0 0.071 13.5 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF953 PF06110.11 CCM03789.1 - 0.077 12.6 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) PA28_alpha PF02251.18 CCM03789.1 - 0.13 12.3 0.2 0.28 11.2 0.2 1.6 1 1 0 1 1 1 0 Proteasome activator pa28 alpha subunit Adaptin_N PF01602.20 CCM03790.1 - 7.4e-98 328.4 5.3 1.1e-97 327.9 5.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 CCM03790.1 - 3.5e-60 201.6 0.0 8.8e-60 200.3 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 CCM03790.1 - 4.8e-53 178.8 0.1 1.7e-52 177.1 0.1 2.0 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 CCM03790.1 - 2.4e-07 31.0 0.5 0.029 14.7 0.0 4.7 3 1 2 5 5 5 3 HEAT repeats Cnd1 PF12717.7 CCM03790.1 - 4e-06 27.0 5.4 0.0029 17.7 0.1 4.0 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CCM03790.1 - 5.1e-06 26.3 0.1 0.13 12.6 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat DUF5578 PF17741.1 CCM03790.1 - 7.7e-05 22.2 8.5 0.035 13.5 1.9 3.9 2 2 3 5 5 5 2 Family of unknown function (DUF5578) Coatomer_g_Cpla PF16381.5 CCM03790.1 - 0.00038 20.6 0.0 0.0015 18.7 0.0 2.1 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform DUF5071 PF16804.5 CCM03790.1 - 0.0083 16.4 0.1 0.28 11.5 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF5071) Gemini_V2 PF01524.17 CCM03790.1 - 0.0087 16.2 0.0 0.14 12.4 0.0 2.8 2 0 0 2 2 2 1 Geminivirus V2 protein Meis_PKNOX_N PF16493.5 CCM03790.1 - 0.013 15.9 0.6 0.068 13.5 0.6 2.3 1 0 0 1 1 1 0 N-terminal of Homeobox Meis and PKNOX1 ParcG PF10274.9 CCM03790.1 - 0.015 15.4 2.8 1 9.5 0.0 3.1 3 1 0 3 3 3 0 Parkin co-regulated protein Yos1 PF08571.10 CCM03790.1 - 0.072 13.4 0.2 12 6.2 0.0 3.5 3 0 0 3 3 3 0 Yos1-like MecA PF05389.12 CCM03790.1 - 0.84 9.2 6.4 5.8 6.5 0.3 3.0 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) Transp_cyt_pur PF02133.15 CCM03791.1 - 1.6e-22 79.9 29.2 2.2e-22 79.4 29.2 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin COX2-transmemb PF09125.10 CCM03791.1 - 5.9 6.8 7.7 1.6 8.6 0.9 2.9 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane Kelch_4 PF13418.6 CCM03792.1 - 4.8e-16 58.5 4.8 1.5e-08 34.5 0.0 4.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 CCM03792.1 - 1.7e-08 34.5 10.1 0.25 11.7 0.0 6.4 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CCM03792.1 - 5e-08 32.7 10.2 0.00058 19.8 0.2 5.4 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 CCM03792.1 - 4.3e-07 30.0 2.7 0.099 13.0 0.0 4.3 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 CCM03792.1 - 8.4e-05 22.1 1.7 0.056 13.0 0.0 3.6 3 0 0 3 3 3 2 Kelch motif PQQ_3 PF13570.6 CCM03792.1 - 0.0079 16.7 0.9 0.31 11.6 0.1 3.2 3 0 0 3 3 3 1 PQQ-like domain Kelch_2 PF07646.15 CCM03792.1 - 0.0079 16.1 8.5 0.29 11.2 0.1 4.8 6 0 0 6 6 6 2 Kelch motif Exo_endo_phos PF03372.23 CCM03794.1 - 2.6e-20 73.0 0.1 3.4e-20 72.6 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3810 PF12725.7 CCM03794.1 - 1.5 8.1 3.6 2.4 7.4 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Abhydrolase_3 PF07859.13 CCM03795.1 - 3e-42 144.9 0.0 5e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_M24 PF00557.24 CCM03795.1 - 2.5e-39 135.1 0.0 3.8e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Say1_Mug180 PF10340.9 CCM03795.1 - 1.7e-14 53.5 0.0 1.6e-13 50.3 0.0 2.0 2 0 0 2 2 2 1 Steryl acetyl hydrolase COesterase PF00135.28 CCM03795.1 - 0.056 12.3 0.0 1.9 7.3 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family Peptidase_S9 PF00326.21 CCM03795.1 - 0.15 11.5 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family RibD_C PF01872.17 CCM03796.1 - 2.4e-27 96.1 0.0 5.2e-27 95.0 0.0 1.5 1 1 0 1 1 1 1 RibD C-terminal domain RhoGEF PF00621.20 CCM03797.1 - 2.3e-09 37.7 0.0 6.5e-07 29.8 0.0 2.3 2 0 0 2 2 2 2 RhoGEF domain BTB PF00651.31 CCM03798.1 - 0.0012 19.1 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Aminotran_4 PF01063.19 CCM03799.1 - 6.4e-23 81.8 0.0 9e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV N_BRCA1_IG PF16158.5 CCM03800.1 - 4.1e-32 111.0 0.1 9.4e-32 109.8 0.1 1.7 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 CCM03800.1 - 9e-12 44.6 14.7 8.3e-09 35.1 4.7 2.5 2 0 0 2 2 2 2 Zinc finger, ZZ type C1_2 PF03107.16 CCM03800.1 - 0.00033 20.9 3.1 0.00033 20.9 3.1 2.3 2 0 0 2 2 2 1 C1 domain AA_permease_N PF08403.10 CCM03800.1 - 0.072 12.6 0.1 1.1 8.8 0.1 2.3 1 1 1 2 2 2 0 Amino acid permease N-terminal Phage_Coat_B PF05356.11 CCM03802.1 - 0.34 10.8 4.6 5.9 6.9 0.4 3.1 3 0 0 3 3 3 0 Phage Coat protein B DUF2970 PF11174.8 CCM03804.1 - 0.15 11.9 2.6 0.36 10.7 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) SNF2_N PF00176.23 CCM03805.1 - 9.1e-47 159.5 0.0 1.2e-38 132.8 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM03805.1 - 2.3e-09 37.6 0.1 5e-09 36.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM03805.1 - 0.086 12.8 0.0 0.96 9.4 0.0 2.7 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit SH3_9 PF14604.6 CCM03806.1 - 8.1e-08 32.0 0.0 1.4e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCM03806.1 - 1.5e-05 24.5 0.0 2.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain hSH3 PF14603.6 CCM03806.1 - 0.012 16.0 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 Helically-extended SH3 domain Presenilin PF01080.17 CCM03806.1 - 0.031 13.1 6.1 0.049 12.4 6.1 1.4 1 0 0 1 1 1 0 Presenilin S1FA PF04689.13 CCM03806.1 - 0.12 12.5 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 DNA binding protein S1FA PRIMA1 PF16101.5 CCM03806.1 - 0.17 11.9 0.0 0.17 11.9 0.0 2.9 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 PI3K_1B_p101 PF10486.9 CCM03806.1 - 0.2 9.4 11.7 0.22 9.3 11.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Shisa PF13908.6 CCM03806.1 - 0.29 11.4 0.0 0.29 11.4 0.0 4.4 1 1 2 3 3 2 0 Wnt and FGF inhibitory regulator RIFIN PF02009.16 CCM03806.1 - 0.47 10.3 2.9 0.79 9.6 2.9 1.3 1 0 0 1 1 1 0 Rifin MAP65_ASE1 PF03999.12 CCM03806.1 - 1.5 7.4 21.6 2.3 6.8 21.6 1.4 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) THEG4 PF15834.5 CCM03806.1 - 6.9 6.6 9.3 9.1 6.2 5.9 2.4 2 0 0 2 2 2 0 Testis highly expressed protein 4 Septin PF00735.18 CCM03807.1 - 8.6e-110 366.4 3.1 1.1e-109 366.2 3.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CCM03807.1 - 8.2e-09 35.5 0.5 6.1e-08 32.7 0.5 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM03807.1 - 2.1e-08 34.2 0.5 1.3e-06 28.5 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CCM03807.1 - 2.5e-06 27.0 0.0 5.5e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 CCM03807.1 - 1.8e-05 24.3 1.9 0.0014 18.2 0.3 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CCM03807.1 - 7.2e-05 22.9 0.7 0.19 11.8 0.2 2.5 1 1 1 2 2 2 2 Dynamin family NB-ARC PF00931.22 CCM03807.1 - 0.0005 19.3 0.3 0.0012 18.1 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain FtsK_SpoIIIE PF01580.18 CCM03807.1 - 0.0016 17.8 0.0 0.0032 16.9 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family T2SSE PF00437.20 CCM03807.1 - 0.0022 17.1 0.1 0.006 15.7 0.1 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 CCM03807.1 - 0.0035 17.7 0.0 0.0057 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CCM03807.1 - 0.0056 16.2 0.2 0.093 12.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 CCM03807.1 - 0.011 16.0 0.0 0.022 15.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain IIGP PF05049.13 CCM03807.1 - 0.013 14.5 1.7 0.067 12.2 0.0 2.3 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 CCM03807.1 - 0.018 15.5 4.2 0.065 13.7 4.1 2.1 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 CCM03807.1 - 0.037 13.8 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 CCM03807.1 - 0.041 14.1 0.0 0.095 12.9 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 CCM03807.1 - 0.064 12.3 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 MCM P-loop domain Ras PF00071.22 CCM03807.1 - 0.078 12.6 0.2 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 Ras family AAA_23 PF13476.6 CCM03807.1 - 0.14 12.6 2.0 0.28 11.6 2.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CCM03807.1 - 0.41 10.7 3.1 0.84 9.7 0.1 2.8 3 1 0 3 3 3 0 AAA domain F-box-like PF12937.7 CCM03808.1 - 0.0038 17.1 1.1 0.0076 16.1 1.1 1.6 1 0 0 1 1 1 1 F-box-like DUF5353 PF17304.2 CCM03809.1 - 0.17 11.7 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5353) TauE PF01925.19 CCM03809.1 - 1.8 8.2 7.9 2.8 7.5 1.7 2.2 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE PLA2_B PF01735.18 CCM03811.1 - 7.2e-98 328.1 0.5 1.1e-97 327.6 0.5 1.2 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Cohesin_load PF10345.9 CCM03812.1 - 0.00011 20.8 0.0 0.29 9.5 0.0 3.0 2 1 0 2 2 2 2 Cohesin loading factor Elong_Iki1 PF10483.9 CCM03814.1 - 0.086 12.3 0.0 0.088 12.3 0.0 1.0 1 0 0 1 1 1 0 Elongator subunit Iki1 Cpn60_TCP1 PF00118.24 CCM03815.1 - 7.3e-157 522.9 5.5 8.3e-157 522.7 5.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF627 PF04781.12 CCM03815.1 - 0.043 13.8 0.1 0.41 10.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF627) ATG101 PF07855.12 CCM03816.1 - 1.6e-20 73.6 0.0 1.8e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 101 Eno-Rase_FAD_bd PF07055.12 CCM03816.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain DUF4763 PF15960.5 CCM03817.1 - 0.00016 21.0 0.6 0.00035 20.0 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) Helo_like_N PF17111.5 CCM03817.1 - 0.091 12.1 2.6 0.49 9.7 0.1 2.7 2 1 1 3 3 3 0 Fungal N-terminal domain of STAND proteins BLOC1_2 PF10046.9 CCM03817.1 - 0.47 10.8 2.2 1.9 8.8 0.1 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF502 PF04367.13 CCM03818.1 - 0.0024 17.8 0.0 2 8.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF502) EI24 PF07264.11 CCM03818.1 - 0.31 11.3 7.0 0.76 10.0 6.8 1.8 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) SNF2_N PF00176.23 CCM03819.1 - 2.6e-67 227.0 0.0 5.6e-67 225.9 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 CCM03819.1 - 1.3e-40 137.9 3.6 4.1e-40 136.4 0.6 3.0 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 CCM03819.1 - 5.6e-32 110.8 4.8 5.6e-32 110.8 4.8 3.9 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 CCM03819.1 - 1.5e-18 67.1 0.0 7.6e-18 64.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM03819.1 - 7.2e-08 32.6 0.8 4.3e-07 30.1 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CCM03819.1 - 1e-05 24.8 0.0 2.7e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DBINO PF13892.6 CCM03819.1 - 0.0034 17.8 5.1 0.0034 17.8 5.1 4.2 5 0 0 5 5 5 1 DNA-binding domain AAA_14 PF13173.6 CCM03819.1 - 0.0086 16.1 0.0 0.04 13.9 0.0 2.2 1 0 0 1 1 1 1 AAA domain CobA_CobO_BtuR PF02572.15 CCM03819.1 - 0.018 15.3 0.6 0.018 15.3 0.6 2.4 3 0 0 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP DUF664 PF04978.12 CCM03819.1 - 8.2 6.8 6.9 4.6 7.7 1.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF664) FHA PF00498.26 CCM03820.1 - 2.1e-05 24.8 0.0 3.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 FHA domain DLH PF01738.18 CCM03821.1 - 5.3e-15 55.6 0.0 1.8e-14 53.8 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family ENTH PF01417.20 CCM03822.1 - 1.4e-45 154.3 0.0 2.4e-45 153.6 0.0 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 CCM03822.1 - 4e-09 35.9 0.2 7.5e-09 35.0 0.2 1.5 1 1 0 1 1 1 1 ANTH domain Nuc_deoxyri_tr2 PF15891.5 CCM03822.1 - 0.75 10.1 4.6 1.8 8.9 1.0 2.4 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like Exo84_C PF16528.5 CCM03823.1 - 8.7e-42 143.3 0.3 2.4e-41 141.8 0.3 1.8 1 1 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 CCM03823.1 - 1.9e-12 47.1 0.1 5.4e-12 45.6 0.1 1.9 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 CCM03823.1 - 0.00019 21.5 0.6 0.00063 19.8 0.6 1.9 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF1028 PF06267.12 CCM03823.1 - 0.084 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF1028) Sec3-PIP2_bind PF15277.6 CCM03823.1 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH PH_13 PF16652.5 CCM03823.1 - 0.14 11.9 0.4 0.34 10.7 0.4 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Heme_oxygenase PF01126.20 CCM03824.1 - 0.036 13.9 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Heme oxygenase Cnn_1N PF07989.11 CCM03824.1 - 0.052 13.7 1.4 0.052 13.7 1.4 3.1 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 PhoU PF01895.19 CCM03824.1 - 0.087 13.3 0.6 0.24 11.9 0.3 1.9 1 1 0 1 1 1 0 PhoU domain adh_short PF00106.25 CCM03824.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase APG6_N PF17675.1 CCM03824.1 - 0.18 12.4 20.8 1.9 9.0 1.4 2.8 2 1 0 2 2 2 0 Apg6 coiled-coil region Fez1 PF06818.15 CCM03824.1 - 1.1 9.6 12.0 3.8 7.9 12.0 1.7 1 1 0 1 1 1 0 Fez1 DUF4200 PF13863.6 CCM03824.1 - 2.9 8.3 17.3 18 5.7 7.3 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) FapA PF03961.13 CCM03824.1 - 3.4 6.2 5.1 0.62 8.6 0.5 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A Csm1_N PF18504.1 CCM03824.1 - 6.7 7.1 15.2 0.23 11.8 1.3 3.1 2 1 1 3 3 3 0 Csm1 N-terminal domain FlxA PF14282.6 CCM03824.1 - 9.8 6.2 14.0 0.28 11.2 6.9 2.1 2 1 0 2 2 2 0 FlxA-like protein DUF974 PF06159.13 CCM03825.1 - 2.3e-74 250.3 0.0 3.3e-74 249.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) MCM_bind PF09739.9 CCM03825.1 - 2.7e-62 211.1 0.0 3.5e-61 207.4 0.0 2.0 1 1 1 2 2 2 2 Mini-chromosome maintenance replisome factor RTC PF01137.21 CCM03826.1 - 1.6e-56 191.0 0.1 4.7e-27 94.6 0.0 2.0 2 0 0 2 2 2 2 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 CCM03826.1 - 2.6e-25 88.9 0.3 6.7e-25 87.6 0.4 1.7 2 0 0 2 2 2 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain HOOK PF05622.12 CCM03827.1 - 4.6e-68 230.0 68.4 3e-64 217.4 47.1 2.7 1 1 1 2 2 2 2 HOOK protein bZIP_1 PF00170.21 CCM03827.1 - 0.0065 16.5 2.6 0.0065 16.5 2.6 7.8 8 2 1 9 9 9 1 bZIP transcription factor TSC22 PF01166.18 CCM03827.1 - 0.01 16.1 2.0 0.01 16.1 2.0 7.2 6 2 3 9 9 9 0 TSC-22/dip/bun family YvfG PF09628.10 CCM03827.1 - 0.015 15.6 1.3 3 8.3 0.0 3.1 2 1 1 3 3 3 0 YvfG protein NYD-SP28_assoc PF14775.6 CCM03827.1 - 0.017 15.2 1.5 0.017 15.2 1.5 5.0 4 0 0 4 4 4 0 Sperm tail C-terminal domain TPR_MLP1_2 PF07926.12 CCM03827.1 - 0.018 15.1 86.7 0.019 15.0 10.7 8.2 5 2 2 7 7 7 0 TPR/MLP1/MLP2-like protein p450 PF00067.22 CCM03828.1 - 2e-73 247.7 0.0 2.5e-73 247.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CDC50 PF03381.15 CCM03829.1 - 9.8e-93 310.7 0.9 1.4e-92 310.2 0.9 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Sugar_tr PF00083.24 CCM03829.1 - 5.2e-36 124.5 1.0 1e-35 123.5 1.0 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter Glyco_hydro_88 PF07470.13 CCM03830.1 - 3.8e-09 36.1 0.0 4.1e-07 29.4 0.0 2.8 2 1 0 2 2 2 2 Glycosyl Hydrolase Family 88 Peptidase_S9 PF00326.21 CCM03831.1 - 2.1e-09 37.2 0.1 7.9e-09 35.3 0.1 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CCM03831.1 - 2.3e-05 24.2 0.3 5.1e-05 23.1 0.3 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM03831.1 - 6.1e-05 22.4 0.1 0.0034 16.7 0.0 2.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 CCM03831.1 - 0.0079 15.9 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 CCM03831.1 - 0.014 14.9 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Tannase PF07519.11 CCM03831.1 - 0.036 13.0 0.0 0.061 12.2 0.0 1.2 1 0 0 1 1 1 0 Tannase and feruloyl esterase Abhydrolase_2 PF02230.16 CCM03831.1 - 0.068 13.0 0.0 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FSH1 PF03959.13 CCM03831.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Esterase_phd PF10503.9 CCM03831.1 - 0.34 10.4 1.6 0.76 9.2 0.0 2.3 3 0 0 3 3 3 0 Esterase PHB depolymerase Not1 PF04054.15 CCM03832.1 - 2.7e-120 401.7 0.1 4.5e-120 400.9 0.1 1.4 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 CCM03832.1 - 9.3e-95 316.3 2.7 8.3e-93 309.9 0.8 2.5 2 0 0 2 2 2 2 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 CCM03832.1 - 2.9e-53 179.7 0.1 6.9e-53 178.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 CCM03832.1 - 6e-53 178.9 0.0 1.3e-52 177.7 0.0 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 CCM03832.1 - 8.3e-45 152.5 0.1 2.7e-44 150.9 0.1 2.0 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat Alpha-amylase PF00128.24 CCM03833.1 - 6.2e-40 137.8 0.0 1e-39 137.1 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CCM03833.1 - 1.7e-15 57.1 0.0 3e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) TMA7 PF09072.10 CCM03834.1 - 4e-25 88.4 21.2 4.4e-25 88.3 21.2 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Aldo_ket_red PF00248.21 CCM03835.1 - 3.9e-68 229.8 0.0 4.4e-68 229.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family V-ATPase_H_N PF03224.14 CCM03836.1 - 2.5e-86 289.9 0.1 3.8e-86 289.2 0.1 1.3 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 CCM03836.1 - 7.9e-44 148.5 1.1 7.2e-43 145.4 0.0 2.8 3 0 0 3 3 3 1 V-ATPase subunit H HEAT PF02985.22 CCM03836.1 - 1.6e-07 31.0 0.0 0.086 13.1 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 CCM03836.1 - 9e-06 26.0 0.0 0.0028 18.0 0.0 3.1 2 0 0 2 2 2 1 HEAT repeats Arm_2 PF04826.13 CCM03836.1 - 0.00012 21.7 0.1 0.004 16.7 0.0 2.8 3 0 0 3 3 3 1 Armadillo-like RTP1_C1 PF10363.9 CCM03836.1 - 0.0026 17.9 0.2 0.13 12.5 0.1 3.0 2 1 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 CCM03836.1 - 0.0072 16.3 3.8 4 7.6 0.1 5.0 5 1 0 5 5 5 1 Armadillo/beta-catenin-like repeat ORC2 PF04084.14 CCM03836.1 - 0.0079 15.1 0.3 0.64 8.9 0.1 2.2 2 0 0 2 2 2 2 Origin recognition complex subunit 2 Proteasom_PSMB PF10508.9 CCM03836.1 - 0.052 12.0 0.3 0.82 8.1 0.0 2.6 2 1 0 3 3 3 0 Proteasome non-ATPase 26S subunit MRP-L46 PF11788.8 CCM03837.1 - 2.2e-18 67.1 0.1 6.4e-18 65.6 0.0 1.7 2 0 0 2 2 2 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 CCM03837.1 - 0.0001 22.4 0.0 0.00021 21.3 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain Endonuclease_NS PF01223.23 CCM03838.1 - 1.1e-55 189.0 0.0 1.3e-55 188.7 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease R3H PF01424.22 CCM03839.1 - 1e-10 41.4 0.3 2.3e-10 40.3 0.3 1.6 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 CCM03839.1 - 7.5e-07 28.9 0.0 2.3e-06 27.3 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_4 PF12763.7 CCM03840.1 - 5e-31 106.7 0.0 3.2e-15 56.0 0.0 3.6 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand GAT PF03127.14 CCM03840.1 - 1.1e-23 83.3 9.9 6.1e-08 32.9 0.2 4.5 3 3 0 3 3 3 3 GAT domain EF-hand_7 PF13499.6 CCM03840.1 - 1.9e-10 41.0 0.1 0.00017 22.0 0.0 4.5 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 CCM03840.1 - 4.3e-08 32.1 0.1 0.00053 19.3 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 CCM03840.1 - 0.00021 21.0 0.0 0.082 12.9 0.0 3.9 3 0 0 3 3 3 1 EF-hand domain PPR_2 PF13041.6 CCM03840.1 - 0.00036 20.7 1.2 0.36 11.0 0.1 2.5 2 0 0 2 2 2 2 PPR repeat family EF-hand_8 PF13833.6 CCM03840.1 - 0.00053 19.8 0.0 0.27 11.1 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CCM03840.1 - 0.0024 17.3 0.0 0.0068 15.9 0.0 1.8 1 0 0 1 1 1 1 EF hand CitT PF12431.8 CCM03840.1 - 0.024 15.0 0.0 0.21 12.0 0.1 2.6 2 0 0 2 2 2 0 Transcriptional regulator PPR PF01535.20 CCM03840.1 - 0.31 11.4 1.4 18 5.9 0.1 2.6 2 0 0 2 2 2 0 PPR repeat Striatin PF08232.12 CCM03841.1 - 2.3e-50 171.2 0.0 2.3e-50 171.2 0.0 2.7 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 CCM03841.1 - 6.7e-36 121.7 2.8 9.5e-05 23.1 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03841.1 - 1e-11 45.0 0.1 0.032 14.5 0.0 5.4 4 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 CCM03841.1 - 0.0043 15.9 0.0 0.052 12.3 0.0 2.5 2 1 1 3 3 3 1 Nup133 N terminal like DUF4482 PF14818.6 CCM03841.1 - 5.3 7.9 12.4 0.98 10.3 4.8 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4482) PDEase_II PF02112.15 CCM03842.1 - 3.5e-29 102.0 0.0 4.2e-28 98.4 0.0 2.4 1 1 0 1 1 1 1 cAMP phosphodiesterases class-II EF-hand_4 PF12763.7 CCM03843.1 - 1.5e-28 98.8 0.0 3.5e-13 49.4 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 CCM03843.1 - 2.3e-07 31.2 0.0 0.00012 22.5 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain pair UBA PF00627.31 CCM03843.1 - 2.9e-06 27.1 0.0 5.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_1 PF00036.32 CCM03843.1 - 0.00094 18.6 0.0 0.96 9.1 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 CCM03843.1 - 0.051 13.5 0.2 5 7.3 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain CENP-F_leu_zip PF10473.9 CCM03843.1 - 0.15 12.0 42.2 0.11 12.5 20.1 3.7 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 CCM03843.1 - 1.8 9.0 34.3 7.6 6.9 0.1 3.2 2 1 1 3 3 3 0 Fez1 TPR_MLP1_2 PF07926.12 CCM03843.1 - 4.6 7.3 42.6 1.3 9.1 14.5 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein UQ_con PF00179.26 CCM03844.1 - 8e-44 148.7 0.0 9.5e-44 148.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CCM03844.1 - 0.00077 19.7 0.0 0.0009 19.5 0.0 1.3 1 0 0 1 1 1 1 RWD domain DUF485 PF04341.12 CCM03846.1 - 8.6 6.4 8.9 1.3 9.0 1.1 2.9 3 0 0 3 3 3 0 Protein of unknown function, DUF485 NAD_binding_7 PF13241.6 CCM03847.1 - 1.2e-28 99.6 0.0 2.7e-28 98.4 0.0 1.6 2 0 0 2 2 2 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 CCM03847.1 - 6.3e-25 86.6 0.8 9.7e-25 86.0 0.8 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 CCM03847.1 - 1.9e-15 56.0 0.9 3.7e-15 55.1 0.9 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central ThiF PF00899.21 CCM03847.1 - 0.45 9.8 1.7 4.9 6.4 0.1 2.3 1 1 1 2 2 2 0 ThiF family MBF1 PF08523.10 CCM03848.1 - 1e-20 73.9 5.5 2.7e-16 59.8 1.8 2.6 2 0 0 2 2 2 2 Multiprotein bridging factor 1 HTH_3 PF01381.22 CCM03848.1 - 3.5e-13 49.4 0.1 5.4e-13 48.8 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CCM03848.1 - 4.6e-05 23.7 0.0 0.00014 22.1 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 CCM03848.1 - 0.00011 22.1 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Tubulin PF00091.25 CCM03849.1 - 7.3e-70 235.2 0.0 1.8e-69 233.9 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCM03849.1 - 1.5e-46 157.7 0.1 3.2e-46 156.6 0.1 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CCM03849.1 - 0.001 19.3 0.0 0.0041 17.4 0.0 1.9 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 CCM03849.1 - 0.0047 16.6 0.0 0.0083 15.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CCM03849.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Hrs_helical PF12210.8 CCM03849.1 - 0.13 12.8 0.4 0.3 11.7 0.4 1.5 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate RNA12 PF10443.9 CCM03851.1 - 1.9e-115 386.2 0.2 1.2e-61 208.8 0.0 2.2 1 1 1 2 2 2 2 RNA12 protein AAA_16 PF13191.6 CCM03851.1 - 0.00044 20.7 3.6 0.0015 19.0 1.8 2.7 2 1 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 CCM03851.1 - 0.0073 16.2 0.0 0.033 14.1 0.0 2.0 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 CCM03851.1 - 0.01 15.0 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) cobW PF02492.19 CCM03851.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RRM_1 PF00076.22 CCM03851.1 - 0.093 12.6 0.0 0.3 10.9 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_22 PF13401.6 CCM03851.1 - 0.12 12.6 0.0 0.43 10.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain SSF PF00474.17 CCM03852.1 - 3.6e-18 65.6 34.9 6.4e-18 64.8 34.9 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family CoA_binding_3 PF13727.6 CCM03852.1 - 4.8 7.2 13.3 0.23 11.4 4.2 2.7 2 0 0 2 2 2 0 CoA-binding domain Bap31 PF05529.12 CCM03852.1 - 5.2 6.9 7.5 1.9 8.4 3.8 2.2 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region DUF2663 PF10864.8 CCM03852.1 - 8.5 6.8 7.2 1.8 9.0 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2663) Sec7 PF01369.20 CCM03853.1 - 3.3e-67 225.7 0.0 5.1e-67 225.1 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CCM03853.1 - 1.5e-18 67.2 0.0 4.5e-18 65.6 0.0 1.9 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 CCM03853.1 - 0.014 15.2 1.2 0.72 9.7 0.1 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF1981) Epimerase PF01370.21 CCM03854.1 - 0.0051 16.3 0.0 0.014 14.9 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Bac_rhodopsin PF01036.18 CCM03855.1 - 1.7e-37 129.1 26.0 2.4e-37 128.7 26.0 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF3309 PF11752.8 CCM03855.1 - 6.3 6.9 14.9 0.61 10.2 8.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3309) MMR_HSR1 PF01926.23 CCM03856.1 - 4.6e-08 33.1 0.2 1.1e-07 31.9 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCM03856.1 - 3.2e-06 26.8 0.1 1.1e-05 25.0 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CCM03856.1 - 3.4e-06 26.6 0.0 6.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Septin PF00735.18 CCM03856.1 - 0.00012 21.5 0.5 0.00025 20.4 0.0 1.7 2 0 0 2 2 2 1 Septin AAA_23 PF13476.6 CCM03856.1 - 0.00063 20.3 4.0 0.029 14.9 0.6 2.2 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CCM03856.1 - 0.0019 18.1 0.2 0.0019 18.1 0.2 1.9 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CCM03856.1 - 0.0087 16.1 3.9 0.43 10.6 0.0 3.2 2 1 1 3 3 3 1 Dynamin family Nup54 PF13874.6 CCM03856.1 - 0.053 13.6 5.5 0.092 12.8 5.5 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 OmpH PF03938.14 CCM03856.1 - 0.085 13.2 3.8 0.17 12.2 3.8 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ABC_tran PF00005.27 CCM03856.1 - 0.096 13.2 0.6 0.4 11.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter GreA_GreB_N PF03449.15 CCM03856.1 - 0.13 12.5 9.8 0.047 13.9 6.2 2.0 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal MADF_DNA_bdg PF10545.9 CCM03856.1 - 0.46 10.8 3.6 4.4 7.7 1.1 2.5 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like CorA PF01544.18 CCM03856.1 - 0.74 9.1 2.5 1.1 8.5 2.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ATP_bind_1 PF03029.17 CCM03856.1 - 1 9.1 3.7 1.7 8.4 0.4 2.6 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 CCM03856.1 - 1.1 9.2 3.5 4 7.5 0.8 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 CCM03857.1 - 2.7e-10 40.3 0.3 6.6e-10 39.1 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCM03857.1 - 1.4e-09 37.6 1.0 1.4e-09 37.6 1.0 1.9 1 1 1 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 CCM03857.1 - 6.1e-05 23.0 0.1 0.00018 21.5 0.1 1.7 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 CCM03857.1 - 8.5e-05 22.7 13.8 0.027 14.5 0.1 3.5 2 2 1 3 3 3 2 Dynamin family Zeta_toxin PF06414.12 CCM03857.1 - 0.0014 18.0 0.5 0.0074 15.6 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Septin PF00735.18 CCM03857.1 - 0.0016 17.8 0.1 0.0016 17.8 0.1 2.3 2 1 0 2 2 2 1 Septin FeoB_N PF02421.18 CCM03857.1 - 0.0017 17.9 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 CCM03857.1 - 0.0029 18.1 4.1 0.02 15.5 0.0 2.8 1 1 1 2 2 2 1 AAA domain T2SSE PF00437.20 CCM03857.1 - 0.0065 15.6 0.1 0.018 14.1 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 CCM03857.1 - 0.026 14.8 1.0 0.088 13.1 0.1 2.3 1 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CCM03857.1 - 0.032 13.6 1.1 0.083 12.2 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.27 CCM03857.1 - 0.043 14.3 6.4 0.81 10.2 6.4 2.5 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 CCM03857.1 - 0.056 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CCM03857.1 - 0.075 13.5 14.5 0.26 11.7 14.5 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM03857.1 - 0.096 12.6 1.4 1.9 8.4 0.3 3.0 2 1 2 4 4 4 0 NACHT domain G-alpha PF00503.20 CCM03857.1 - 0.12 11.6 4.2 2.4 7.2 4.2 2.2 1 1 0 1 1 1 0 G-protein alpha subunit FAD_syn PF06574.12 CCM03857.1 - 0.16 11.8 0.8 0.6 10.0 0.0 2.1 2 0 0 2 2 2 0 FAD synthetase AAA_16 PF13191.6 CCM03857.1 - 0.4 11.1 3.0 1.4 9.2 3.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CCM03857.1 - 0.96 9.6 4.6 0.55 10.4 0.2 2.5 2 2 1 3 3 3 0 AAA domain DUF87 PF01935.17 CCM03857.1 - 1.3 9.1 13.2 1.2 9.2 0.3 3.1 2 1 0 2 2 2 0 Helicase HerA, central domain TMPIT PF07851.13 CCM03857.1 - 2.6 7.2 5.9 4 6.6 5.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein Fmp27_WPPW PF10359.9 CCM03859.1 - 0.0065 15.4 0.5 0.0088 14.9 0.5 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain AIG1 PF04548.16 CCM03859.1 - 0.054 12.8 0.1 0.1 11.9 0.1 1.6 1 1 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 CCM03859.1 - 0.078 13.0 0.1 2.4 8.2 0.0 2.3 2 0 0 2 2 2 0 Dynamin family V-SNARE PF05008.15 CCM03859.1 - 0.35 11.3 9.1 0.72 10.3 9.1 1.6 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Spc7 PF08317.11 CCM03859.1 - 0.52 9.2 10.3 0.72 8.7 10.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 CCM03859.1 - 0.53 9.8 3.3 0.77 9.3 3.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 CCM03859.1 - 0.59 9.3 2.8 0.86 8.8 2.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 CCM03859.1 - 0.87 8.1 4.5 1.2 7.6 4.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF612 PF04747.12 CCM03859.1 - 5 6.1 5.6 7.7 5.5 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF612 DUF724 PF05266.14 CCM03859.1 - 8.9 6.1 10.3 6.2 6.6 8.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) NAD_binding_2 PF03446.15 CCM03860.1 - 1.1e-34 119.9 0.3 1.6e-34 119.4 0.3 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CCM03860.1 - 1.8e-31 108.9 0.0 3.4e-31 108.0 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Cytochrom_B561 PF03188.16 CCM03861.1 - 1e-07 32.1 5.6 1e-07 32.1 5.6 2.5 1 1 2 3 3 3 2 Eukaryotic cytochrome b561 DUF1656 PF07869.12 CCM03861.1 - 0.028 14.4 4.6 0.028 14.4 4.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) Phage_holin_2_3 PF16080.5 CCM03861.1 - 8.9 6.2 8.0 1.8 8.4 1.2 3.0 3 0 0 3 3 3 0 Bacteriophage holin family HP1 Pkinase PF00069.25 CCM03862.1 - 1.6e-19 70.3 0.0 3.9e-19 69.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03862.1 - 1.6e-10 40.7 0.0 4.8e-10 39.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase DEAD PF00270.29 CCM03863.1 - 1.4e-20 73.8 0.0 2.5e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 CCM03863.1 - 3.2e-15 56.6 0.8 1.3e-14 54.7 0.8 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 CCM03863.1 - 6.1e-13 49.1 0.0 1e-10 42.0 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CDT1 PF08839.11 CCM03863.1 - 1.2e-06 29.0 0.0 1.9e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 DNA replication factor CDT1 like ResIII PF04851.15 CCM03863.1 - 0.0001 22.4 0.0 0.00019 21.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Abhydrolase_1 PF00561.20 CCM03864.1 - 1.2e-21 77.5 0.1 1.7e-18 67.2 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM03864.1 - 3.9e-13 50.5 0.0 5.1e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM03864.1 - 6.2e-11 42.0 0.0 7.5e-10 38.5 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CCM03864.1 - 4.5e-05 23.4 0.0 0.0001 22.2 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 CCM03864.1 - 0.0068 16.5 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_4 PF08386.10 CCM03864.1 - 0.011 15.8 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Peptidase_S9 PF00326.21 CCM03864.1 - 0.022 14.2 0.1 5.4 6.4 0.0 2.5 2 1 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 CCM03864.1 - 0.082 12.6 0.0 0.19 11.4 0.1 1.8 1 1 0 1 1 1 0 Serine hydrolase (FSH1) BAAT_C PF08840.11 CCM03864.1 - 0.098 12.6 0.0 0.2 11.5 0.0 1.4 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal SPT16 PF08644.11 CCM03865.1 - 8.2e-58 194.9 1.6 1.4e-57 194.1 0.2 2.2 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 CCM03865.1 - 5.6e-35 120.5 0.0 6.4e-34 117.1 0.0 2.6 1 1 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 CCM03865.1 - 5.5e-27 94.8 0.0 9.3e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 CCM03865.1 - 1.3e-14 54.4 0.0 3.4e-14 53.0 0.0 1.8 1 0 0 1 1 1 1 Histone chaperone Rttp106-like DUF3956 PF13104.6 CCM03865.1 - 0.078 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3956) AMP-binding PF00501.28 CCM03866.1 - 2e-15 56.3 0.0 1.5e-14 53.5 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme DUF2420 PF10336.9 CCM03867.1 - 2.8e-07 30.5 0.0 8.3e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) WD40 PF00400.32 CCM03868.1 - 1e-59 197.1 16.4 4e-09 36.9 0.1 9.0 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM03868.1 - 1.1e-31 109.0 0.0 7.3e-06 26.2 0.0 8.1 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM03868.1 - 3.8e-14 52.4 1.2 0.086 11.8 0.0 7.1 2 2 4 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCM03868.1 - 6.7e-08 32.2 0.0 0.26 10.5 0.0 4.2 3 1 1 4 4 4 2 WD40-like domain PD40 PF07676.12 CCM03868.1 - 3e-06 27.0 12.0 8.5 6.4 0.0 7.2 8 0 0 8 8 8 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 CCM03868.1 - 0.00069 19.0 1.0 5.8 6.1 0.0 4.6 2 2 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 CCM03868.1 - 0.0051 16.5 6.7 9.4 6.0 0.0 6.2 6 0 0 6 6 6 1 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 CCM03868.1 - 0.014 14.0 1.1 0.3 9.6 0.1 3.1 1 1 3 4 4 4 0 Cytochrome D1 heme domain Nup160 PF11715.8 CCM03868.1 - 0.02 13.5 4.8 0.86 8.2 0.1 4.0 1 1 2 4 4 4 0 Nucleoporin Nup120/160 DUF4875 PF16175.5 CCM03868.1 - 0.052 13.7 1.8 3.6 7.7 0.0 4.1 1 1 3 5 5 5 0 Domain of unknown function (DUF4875) Glyco_hydro_79C PF16862.5 CCM03869.1 - 9.4e-21 74.6 0.1 2.5e-20 73.3 0.1 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain Meth_synt_2 PF01717.18 CCM03870.1 - 3.7e-15 56.0 0.1 1.5e-11 44.2 0.0 2.1 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CCM03870.1 - 5.7e-05 22.8 0.0 0.3 10.5 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain Glyco_hydro_92 PF07971.12 CCM03871.1 - 2.2e-149 498.4 4.4 2.6e-149 498.1 4.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CCM03871.1 - 1.2e-53 182.4 0.7 1.9e-53 181.8 0.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DnaJ PF00226.31 CCM03872.1 - 6.8e-19 67.8 0.2 6.8e-19 67.8 0.2 2.4 3 0 0 3 3 3 1 DnaJ domain TPR_19 PF14559.6 CCM03872.1 - 7.2e-13 48.9 10.5 0.15 12.6 0.1 6.7 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 CCM03872.1 - 2.7e-09 36.4 1.1 0.00045 19.9 0.1 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCM03872.1 - 1e-07 31.5 12.4 0.025 14.7 0.1 6.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCM03872.1 - 2.3e-06 27.6 11.6 0.025 14.7 0.3 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM03872.1 - 7.5e-06 26.5 14.7 8.1e-05 23.2 0.5 4.4 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CCM03872.1 - 0.00014 22.1 11.9 0.033 14.5 0.1 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCM03872.1 - 0.0012 18.7 1.4 16 5.8 0.2 5.0 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCM03872.1 - 0.0014 19.3 17.0 0.063 14.1 0.1 6.2 5 2 2 7 7 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM03872.1 - 0.0014 18.8 7.0 0.082 13.1 0.1 3.9 4 1 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 CCM03872.1 - 0.0019 18.6 1.4 10 7.1 0.4 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CCM03872.1 - 0.0023 17.6 5.1 4.4 7.1 0.0 4.8 4 1 1 5 5 5 2 TPR repeat TPR_8 PF13181.6 CCM03872.1 - 0.0034 17.5 10.8 3.7 8.0 0.1 5.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 CCM03872.1 - 0.0047 17.2 1.3 20 5.8 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCM03872.1 - 0.027 14.3 0.5 18 5.4 0.3 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCM03872.1 - 0.047 14.3 10.5 11 6.9 0.0 5.9 7 0 0 7 7 5 0 Tetratricopeptide repeat TetR_C_11 PF16859.5 CCM03872.1 - 3.9 7.8 6.9 25 5.2 1.8 3.3 3 1 2 5 5 5 0 Tetracyclin repressor-like, C-terminal domain DIOX_N PF14226.6 CCM03873.1 - 2e-15 57.6 0.0 3.6e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM03873.1 - 8.9e-14 51.8 0.0 1.9e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cupin_1 PF00190.22 CCM03875.1 - 4.1e-20 71.9 0.1 2.4e-19 69.4 0.1 1.9 1 1 0 1 1 1 1 Cupin Cupin_2 PF07883.11 CCM03875.1 - 5.7e-16 58.0 0.2 8.5e-16 57.4 0.2 1.3 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 CCM03875.1 - 5.7e-06 26.3 0.0 7.8e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_3 PF05899.12 CCM03875.1 - 1.3e-05 24.8 0.1 2.3e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) LTD PF00932.19 CCM03875.1 - 0.037 14.4 0.0 0.28 11.5 0.0 2.1 2 0 0 2 2 2 0 Lamin Tail Domain Cupin_8 PF13621.6 CCM03875.1 - 0.045 13.5 0.0 0.089 12.5 0.0 1.6 1 1 0 1 1 1 0 Cupin-like domain Glyoxalase PF00903.25 CCM03877.1 - 1.9e-27 96.0 0.1 2.2e-27 95.7 0.1 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CCM03877.1 - 3.2e-08 33.8 0.0 4.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CCM03877.1 - 9.9e-07 29.5 0.0 1.6e-06 28.8 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CCM03877.1 - 0.00016 21.6 0.0 0.0015 18.5 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CCM03877.1 - 0.00026 21.1 0.0 0.00063 19.9 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain CppA_N PF14506.6 CCM03877.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 CppA N-terminal Glyoxalase PF00903.25 CCM03878.1 - 1.8e-19 70.2 0.0 2.5e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CCM03878.1 - 5.5e-05 23.4 0.0 0.039 14.2 0.0 2.0 1 1 1 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CCM03878.1 - 0.00043 21.1 0.0 0.00058 20.6 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CCM03878.1 - 0.084 12.8 0.0 7.8 6.5 0.0 2.2 2 0 0 2 2 2 0 Glyoxalase-like domain CppA_N PF14506.6 CCM03878.1 - 0.16 12.0 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 CppA N-terminal PC-Esterase PF13839.6 CCM03879.1 - 1.9e-07 31.1 0.0 0.02 14.6 0.0 2.2 2 0 0 2 2 2 2 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Acetyltransf_10 PF13673.7 CCM03880.1 - 9.1e-10 38.6 0.0 2.3e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM03880.1 - 6.6e-08 32.8 0.0 2.4e-07 31.0 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCM03880.1 - 6.7e-07 29.6 0.0 2.1e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM03880.1 - 0.00014 21.7 0.0 0.00034 20.5 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CCM03880.1 - 0.00022 21.3 0.0 0.00048 20.2 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 CCM03880.1 - 0.0069 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_9 PF13527.7 CCM03880.1 - 0.015 15.4 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3417 PF11897.8 CCM03881.1 - 0.00022 21.6 0.3 0.31 11.5 0.1 3.1 1 1 2 3 3 3 2 Protein of unknown function (DUF3417) Auxin_inducible PF02519.14 CCM03881.1 - 0.0065 16.6 0.1 5.1 7.3 0.0 2.3 2 0 0 2 2 2 2 Auxin responsive protein MKRN1_C PF15815.5 CCM03881.1 - 0.013 15.8 1.1 7.7 7.0 0.1 2.6 3 0 0 3 3 3 0 E3 ubiquitin-protein ligase makorin-1, C-terminal FRG PF08867.11 CCM03881.1 - 0.029 15.3 0.8 2.6 9.1 0.1 2.3 1 1 1 2 2 2 0 FRG domain DUF5319 PF17252.2 CCM03881.1 - 0.067 13.4 0.5 10 6.3 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5319) AMIN PF11741.8 CCM03881.1 - 0.15 12.2 0.2 17 5.6 0.0 2.2 2 0 0 2 2 2 0 AMIN domain Fungal_trans PF04082.18 CCM03882.1 - 2.3e-11 43.2 0.3 4.6e-11 42.2 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM03882.1 - 0.012 15.7 4.2 0.022 14.9 4.2 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Copper-fist PF00649.18 CCM03882.1 - 0.11 12.0 3.0 0.24 10.9 3.0 1.5 1 0 0 1 1 1 0 Copper fist DNA binding domain Glyco_hydro_18 PF00704.28 CCM03883.1 - 3.7e-61 207.6 3.0 4.7e-61 207.2 3.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 FA_hydroxylase PF04116.13 CCM03884.1 - 3.1e-23 82.6 19.2 3.1e-23 82.6 19.2 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Kre28 PF17097.5 CCM03884.1 - 0.032 13.2 0.1 0.051 12.5 0.1 1.3 1 0 0 1 1 1 0 Spindle pole body component Mating_N PF12731.7 CCM03884.1 - 0.11 12.6 0.5 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 Mating-type protein beta 1 FUSC_2 PF13515.6 CCM03886.1 - 4.6e-26 91.4 9.4 4.6e-26 91.4 9.4 2.6 3 0 0 3 3 3 1 Fusaric acid resistance protein-like FUSC PF04632.12 CCM03886.1 - 2.8e-14 52.6 23.1 2e-11 43.2 6.7 4.2 3 1 1 4 4 4 3 Fusaric acid resistance protein family ArAE_2 PF10334.9 CCM03886.1 - 3.3e-11 43.5 0.2 1.7e-09 37.9 0.0 2.3 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 ALMT PF11744.8 CCM03886.1 - 7.2e-11 41.6 7.2 1.7e-09 37.1 5.0 2.3 2 0 0 2 2 2 2 Aluminium activated malate transporter FUSC-like PF12805.7 CCM03886.1 - 0.31 10.1 9.8 0.84 8.7 1.4 2.7 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS ArAE_1 PF06081.11 CCM03886.1 - 0.56 10.3 11.3 0.046 13.9 1.3 3.1 3 1 0 3 3 3 0 Aromatic acid exporter family member 1 API5 PF05918.11 CCM03887.1 - 6.8e-24 84.6 0.1 6.8e-24 84.6 0.1 2.0 2 0 0 2 2 2 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.6 CCM03887.1 - 0.00059 20.2 0.1 0.0016 18.8 0.1 1.7 1 0 0 1 1 1 1 HEAT repeats Adaptin_N PF01602.20 CCM03887.1 - 0.002 16.7 0.0 0.0033 16.0 0.0 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cyt-b5 PF00173.28 CCM03888.1 - 8.7e-13 48.2 0.2 1.1e-12 47.8 0.2 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain G-alpha PF00503.20 CCM03889.1 - 2.3e-116 388.8 0.2 2.7e-116 388.6 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCM03889.1 - 2.5e-16 59.6 1.9 9.3e-12 44.7 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM03889.1 - 5.3e-05 22.7 1.1 0.0029 17.0 0.0 2.4 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 CCM03889.1 - 0.0033 17.6 0.1 2.8 8.2 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCM03889.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CCM03889.1 - 0.05 13.7 0.0 1.9 8.6 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 CCM03889.1 - 0.096 12.0 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family GTP_EFTU PF00009.27 CCM03889.1 - 0.14 11.6 0.1 7.2 6.1 0.0 2.6 1 1 2 3 3 3 0 Elongation factor Tu GTP binding domain BCS1_N PF08740.11 CCM03890.1 - 2.1e-44 151.7 2.9 2.1e-44 151.7 2.9 1.8 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 CCM03890.1 - 5.5e-15 55.9 0.2 5.6e-07 30.0 0.0 2.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CCM03890.1 - 0.00011 21.5 0.0 0.00026 20.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 CCM03890.1 - 0.001 18.7 0.1 0.017 14.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM03890.1 - 0.011 16.1 4.5 0.011 16.1 0.1 2.7 2 1 0 2 2 2 0 AAA ATPase domain Viral_helicase1 PF01443.18 CCM03890.1 - 0.08 12.7 0.1 0.25 11.0 0.0 1.8 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 CCM03890.1 - 0.083 13.4 10.7 10 6.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CCM03890.1 - 0.11 13.0 1.9 0.16 12.5 0.0 2.2 2 1 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.23 CCM03890.1 - 0.17 12.0 0.4 0.63 10.1 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.6 CCM03890.1 - 2 8.9 0.0 2 8.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain TSP_NTD PF17804.1 CCM03890.1 - 3.6 7.8 8.8 8.4 6.6 8.8 1.6 1 0 0 1 1 1 0 Tail specific protease N-terminal domain Sensor PF13796.6 CCM03892.1 - 0.0018 18.3 17.5 0.14 12.2 17.5 2.5 1 1 0 1 1 1 1 Putative sensor DIOX_N PF14226.6 CCM03893.1 - 6.1e-31 107.6 0.1 9.7e-31 107.0 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM03893.1 - 4.4e-18 65.6 0.0 1.1e-17 64.3 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily RecG_N PF17190.4 CCM03893.1 - 0.025 15.3 0.0 0.064 14.0 0.0 1.6 1 0 0 1 1 1 0 RecG N-terminal helical domain PWWP PF00855.17 CCM03895.1 - 3.2e-21 75.5 0.8 1.2e-20 73.7 0.8 2.2 1 1 0 1 1 1 1 PWWP domain Med26 PF08711.11 CCM03895.1 - 0.0014 18.6 0.0 0.0031 17.5 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain RNA_polI_A34 PF08208.11 CCM03895.1 - 0.0021 18.2 4.8 0.0021 18.2 4.8 3.6 2 1 1 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 Sec2p PF06428.11 CCM03896.1 - 1e-10 41.4 12.6 1e-10 41.4 12.6 2.9 4 1 1 5 5 5 1 GDP/GTP exchange factor Sec2p Herpes_UL25 PF01499.16 CCM03896.1 - 0.091 11.3 4.2 0.073 11.6 2.3 1.7 1 1 1 2 2 2 0 Herpesvirus UL25 family Yuri_gagarin PF15934.5 CCM03896.1 - 0.25 11.2 7.0 0.56 10.0 7.0 1.5 1 0 0 1 1 1 0 Yuri gagarin zf-C4H2 PF10146.9 CCM03896.1 - 0.25 11.6 13.5 0.04 14.2 7.4 2.7 2 1 1 3 3 3 0 Zinc finger-containing protein RasGAP_C PF03836.15 CCM03896.1 - 0.83 9.8 6.0 11 6.1 0.4 2.3 1 1 1 2 2 2 0 RasGAP C-terminus Fez1 PF06818.15 CCM03896.1 - 1 9.8 16.7 0.077 13.4 9.6 2.2 2 0 0 2 2 2 0 Fez1 DUF4407 PF14362.6 CCM03896.1 - 1.1 8.6 9.6 0.089 12.1 3.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HSP70 PF00012.20 CCM03896.1 - 1.1 7.3 4.3 2.1 6.4 4.3 1.3 1 0 0 1 1 1 0 Hsp70 protein DUF501 PF04417.12 CCM03896.1 - 8.2 6.2 8.5 0.82 9.5 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF501) FapA PF03961.13 CCM03896.1 - 9.8 4.7 8.7 1.1 7.8 4.5 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A Pkinase PF00069.25 CCM03897.1 - 2e-10 40.5 0.0 5.1e-08 32.6 0.0 2.4 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03897.1 - 0.0044 16.3 0.0 0.01 15.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CCM03897.1 - 0.15 11.4 0.1 0.27 10.6 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ELP6 PF09807.9 CCM03898.1 - 3e-11 43.2 0.0 5.8e-11 42.3 0.0 1.5 1 1 0 1 1 1 1 Elongation complex protein 6 MMtag PF10159.9 CCM03899.1 - 8.4e-31 106.1 2.3 8.4e-31 106.1 2.3 2.8 3 0 0 3 3 3 1 Multiple myeloma tumor-associated DUF4407 PF14362.6 CCM03899.1 - 2 7.7 6.1 2.9 7.2 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DEAD PF00270.29 CCM03901.1 - 2.1e-09 37.4 0.3 3.4e-09 36.7 0.3 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase SRP54 PF00448.22 CCM03901.1 - 1.9e-05 24.4 0.4 6.8e-05 22.6 0.4 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 CCM03901.1 - 4.8e-05 23.6 0.0 0.00011 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CCM03901.1 - 0.00026 20.6 0.1 0.0083 15.7 0.1 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 CCM03901.1 - 0.00034 21.0 0.1 0.00064 20.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCM03901.1 - 0.0028 17.4 0.0 0.0041 16.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCM03901.1 - 0.0033 16.5 0.0 0.0063 15.6 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein ResIII PF04851.15 CCM03901.1 - 0.011 15.8 0.1 3.1 7.8 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CCM03901.1 - 0.022 14.0 0.0 0.029 13.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 CCM03901.1 - 0.026 14.0 0.1 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein ABC_tran PF00005.27 CCM03901.1 - 0.037 14.5 0.1 0.077 13.5 0.1 1.5 1 1 0 1 1 1 0 ABC transporter Flavi_DEAD PF07652.14 CCM03901.1 - 0.049 13.6 0.1 0.094 12.7 0.1 1.5 1 1 0 1 1 1 0 Flavivirus DEAD domain AAA_24 PF13479.6 CCM03901.1 - 0.096 12.4 0.0 0.19 11.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CCM03901.1 - 0.11 13.0 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CCM03901.1 - 0.13 12.3 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 CCM03901.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ANAPC4_WD40 PF12894.7 CCM03902.1 - 4.9e-07 30.0 0.0 0.02 15.2 0.0 4.9 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCM03902.1 - 5.6 8.0 9.7 5.2 8.1 0.1 5.0 6 0 0 6 6 6 0 WD domain, G-beta repeat adh_short PF00106.25 CCM03903.1 - 4.1e-21 75.3 0.1 3.2e-12 46.3 0.1 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM03903.1 - 4.8e-11 42.7 1.7 1e-05 25.2 1.1 2.4 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM03903.1 - 3.4e-05 23.8 0.3 0.00034 20.6 0.0 2.3 2 1 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CCM03903.1 - 0.0002 21.3 1.2 0.00065 19.6 0.2 2.1 2 1 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CCM03903.1 - 0.036 13.2 0.0 2.2 7.3 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Hydrophobin PF01185.18 CCM03904.1 - 2.9e-20 72.7 6.3 4.3e-20 72.1 6.3 1.3 1 0 0 1 1 1 1 Fungal hydrophobin Toxin_12 PF07740.12 CCM03904.1 - 1.4 9.7 6.7 3.9 8.3 0.3 2.5 2 1 0 2 2 2 0 Ion channel inhibitory toxin EspB PF05802.11 CCM03906.1 - 0.054 13.5 3.4 0.063 13.3 3.4 1.2 1 0 0 1 1 1 0 Enterobacterial EspB protein ABC_tran PF00005.27 CCM03907.1 - 3.1e-48 163.8 0.0 3.2e-28 98.9 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCM03907.1 - 5.1e-41 141.1 28.7 1.4e-24 87.2 11.3 3.6 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 CCM03907.1 - 4.1e-12 46.0 2.9 0.0056 16.1 0.3 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM03907.1 - 9.3e-09 36.1 3.0 0.00023 21.7 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 CCM03907.1 - 9.6e-07 28.9 6.4 0.0076 16.1 0.1 4.5 2 2 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM03907.1 - 2e-06 27.5 0.2 0.028 14.1 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM03907.1 - 3e-06 27.7 0.1 0.051 14.0 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CCM03907.1 - 7e-05 22.5 0.0 0.46 10.0 0.0 2.7 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 CCM03907.1 - 8.6e-05 22.6 0.2 0.19 11.8 0.0 3.2 3 0 0 3 3 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 CCM03907.1 - 0.00036 19.7 0.1 0.041 12.9 0.0 2.6 3 0 0 3 3 3 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 CCM03907.1 - 0.00047 20.1 0.1 0.74 9.7 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_22 PF13401.6 CCM03907.1 - 0.00084 19.6 0.3 1.1 9.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 CCM03907.1 - 0.00085 18.8 0.0 0.31 10.4 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family IstB_IS21 PF01695.17 CCM03907.1 - 0.0015 18.2 0.4 2.9 7.6 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein DUF87 PF01935.17 CCM03907.1 - 0.0018 18.4 1.1 0.11 12.6 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain ATPase_2 PF01637.18 CCM03907.1 - 0.0031 17.4 0.0 0.22 11.4 0.0 2.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CCM03907.1 - 0.0053 16.3 0.0 0.87 9.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_15 PF13175.6 CCM03907.1 - 0.0069 16.1 0.1 0.3 10.8 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Adeno_IVa2 PF02456.15 CCM03907.1 - 0.0086 14.9 0.3 0.18 10.5 0.0 2.3 2 0 0 2 2 2 1 Adenovirus IVa2 protein AAA_5 PF07728.14 CCM03907.1 - 0.024 14.7 0.3 9.7 6.2 0.1 3.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 CCM03907.1 - 0.024 14.4 0.1 6.8 6.4 0.2 3.0 2 1 0 2 2 2 0 DEAD/DEAH box helicase ResIII PF04851.15 CCM03907.1 - 0.025 14.6 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Pox_A32 PF04665.12 CCM03907.1 - 0.04 13.4 0.3 10 5.5 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein Dynamin_N PF00350.23 CCM03907.1 - 0.043 13.9 0.1 6.5 6.8 0.0 3.0 3 0 0 3 3 3 0 Dynamin family AAA PF00004.29 CCM03907.1 - 0.063 13.7 0.7 2.4 8.6 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 CCM03907.1 - 0.078 11.9 0.3 7.7 5.3 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 CCM03907.1 - 0.11 13.1 0.0 28 5.3 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_11 PF13086.6 CCM03907.1 - 0.14 11.9 1.4 0.78 9.5 0.3 2.7 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 CCM03907.1 - 0.32 10.6 3.1 0.87 9.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 CCM03907.1 - 1.5 8.7 5.3 6.2 6.7 0.1 3.2 3 0 0 3 3 3 0 NACHT domain Peptidase_M56 PF05569.11 CCM03908.1 - 0.17 11.1 0.0 0.17 11.1 0.0 1.9 1 1 1 2 2 2 0 BlaR1 peptidase M56 Lipase_GDSL_2 PF13472.6 CCM03909.1 - 1.5e-28 100.4 0.3 2e-28 100.0 0.3 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCM03909.1 - 1.2e-18 67.8 0.0 1.6e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase HECT PF00632.25 CCM03910.1 - 2.4e-95 319.5 0.0 3.2e-95 319.2 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 CCM03910.1 - 1.7e-37 127.2 19.3 2.7e-13 49.8 5.1 3.7 3 0 0 3 3 3 3 WW domain C2 PF00168.30 CCM03910.1 - 2.9e-18 66.1 0.1 7.1e-18 64.8 0.1 1.7 1 0 0 1 1 1 1 C2 domain MHC_II_alpha PF00993.20 CCM03910.1 - 0.14 11.9 1.9 1.1 9.0 0.0 3.3 5 0 0 5 5 5 0 Class II histocompatibility antigen, alpha domain ERAP1_C PF11838.8 CCM03911.1 - 3.5e-65 220.6 0.7 5.6e-65 219.9 0.7 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CCM03911.1 - 2.9e-51 174.1 0.0 6.7e-51 172.9 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CCM03911.1 - 3.8e-37 128.3 0.0 7.5e-37 127.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Bestrophin PF01062.21 CCM03913.1 - 1.9e-39 135.8 0.0 2.7e-19 69.7 0.0 2.2 1 1 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel 2Fe-2S_thioredx PF01257.19 CCM03914.1 - 5.4e-57 191.7 0.1 6.6e-57 191.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Pkinase PF00069.25 CCM03915.1 - 5.3e-64 216.1 0.0 6.2e-64 215.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM03915.1 - 7.8e-25 87.6 0.0 1e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM03915.1 - 0.0011 18.3 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCM03915.1 - 0.012 15.6 0.0 0.04 13.8 0.0 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM03915.1 - 0.017 14.7 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA2 PF13095.6 CCM03915.1 - 0.1 12.2 0.0 0.33 10.5 0.0 1.6 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CCM03915.1 - 0.21 10.3 0.0 8.8 5.0 0.1 2.1 1 1 0 2 2 2 0 Fungal protein kinase WD40 PF00400.32 CCM03916.1 - 6.2e-39 131.3 26.2 2.6e-08 34.4 0.1 9.2 7 2 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 CCM03916.1 - 2.5e-12 46.5 0.2 2.5e-12 46.5 0.2 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM03916.1 - 1.6e-10 40.6 0.1 4e-10 39.3 0.1 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 CCM03916.1 - 1.9e-09 36.8 10.8 0.04 12.6 0.2 5.2 2 1 3 5 5 5 5 Nucleoporin Nup120/160 F-box_4 PF15966.5 CCM03916.1 - 0.0007 19.5 0.0 0.0022 17.9 0.0 1.8 1 0 0 1 1 1 1 F-box DUF4939 PF16297.5 CCM03916.1 - 0.0022 17.8 0.0 0.0046 16.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) MIF4G PF02854.19 CCM03917.1 - 1.6e-49 168.4 0.2 3.3e-49 167.4 0.2 1.5 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 CCM03917.1 - 2e-19 69.5 0.0 6.7e-19 67.8 0.0 1.9 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 MA3 PF02847.17 CCM03917.1 - 1.9e-07 31.1 0.1 6.8e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 MA3 domain DUF3445 PF11927.8 CCM03919.1 - 9.4e-63 211.8 0.0 1.2e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) PalH PF08733.10 CCM03920.1 - 0.62 9.0 15.2 2.5 7.0 15.1 1.9 1 1 0 1 1 1 0 PalH/RIM21 PHC2_SAM_assoc PF16616.5 CCM03920.1 - 6.9 7.5 5.9 7.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Cupredoxin_1 PF13473.6 CCM03922.1 - 0.11 12.6 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Cupredoxin-like domain FAD_binding_3 PF01494.19 CCM03923.1 - 6.9e-78 262.3 0.0 8.8e-78 262.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM03923.1 - 2.7e-05 23.6 0.3 0.0035 16.6 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM03923.1 - 5.1e-05 22.5 0.1 0.011 14.9 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CCM03923.1 - 0.00031 20.1 0.2 0.00081 18.7 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM03923.1 - 0.00086 18.6 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CCM03923.1 - 0.0012 19.0 0.0 0.0037 17.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCM03923.1 - 0.0056 17.2 0.2 6.3 7.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM03923.1 - 0.0057 15.4 0.2 0.038 12.7 0.1 2.2 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 CCM03923.1 - 0.097 11.7 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCM03923.1 - 0.2 10.9 0.1 0.2 10.9 0.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Glyco_transf_8 PF01501.20 CCM03924.1 - 1.3e-07 31.4 0.1 4.1e-07 29.8 0.1 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 8 Methyltransf_30 PF05430.11 CCM03924.1 - 0.085 12.7 0.0 12 5.8 0.0 2.9 3 0 0 3 3 3 0 S-adenosyl-L-methionine-dependent methyltransferase Glyco_transf_8 PF01501.20 CCM03925.1 - 5.3e-08 32.7 0.5 2.8e-06 27.1 0.5 2.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 CCM03925.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase UPF0029 PF01205.19 CCM03926.1 - 1e-18 67.6 0.0 1.9e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 DUF5398 PF17376.2 CCM03926.1 - 0.044 14.4 0.9 0.073 13.7 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5398) T3SS_needle_E PF08988.10 CCM03926.1 - 0.061 13.5 1.5 0.65 10.2 0.2 2.3 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle RSN1_7TM PF02714.15 CCM03927.1 - 1.7e-77 260.4 26.0 1.7e-77 260.4 26.0 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCM03927.1 - 2.7e-39 135.2 0.0 4.2e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CCM03927.1 - 5.9e-37 126.8 2.1 5.9e-37 126.8 2.1 3.2 4 0 0 4 4 4 2 Late exocytosis, associated with Golgi transport Glyco_transf_8 PF01501.20 CCM03928.1 - 2e-08 34.1 0.5 1.1e-07 31.7 0.5 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 CCM03928.1 - 0.12 12.4 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Glyco_transf_8 PF01501.20 CCM03929.1 - 7.4e-08 32.3 0.0 2.8e-06 27.1 0.0 2.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 CCM03929.1 - 0.054 13.5 0.1 0.088 12.8 0.1 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase PPR_2 PF13041.6 CCM03930.1 - 2.5e-05 24.3 0.0 0.021 15.0 0.0 4.5 3 1 1 4 4 4 1 PPR repeat family PPR_long PF17177.4 CCM03930.1 - 0.00018 20.9 0.4 0.0092 15.4 0.1 2.9 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 CCM03930.1 - 0.00058 19.9 0.0 0.18 11.9 0.0 4.1 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR PF01535.20 CCM03930.1 - 0.011 16.0 4.6 1.9 8.9 0.3 5.6 6 1 0 6 6 6 0 PPR repeat FSH1 PF03959.13 CCM03931.1 - 8.4e-44 149.8 0.0 5.8e-43 147.0 0.0 1.9 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 CCM03931.1 - 0.0014 18.3 0.0 0.6 9.7 0.0 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold Thioesterase PF00975.20 CCM03931.1 - 0.016 15.3 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Hydrolase_4 PF12146.8 CCM03931.1 - 0.027 13.7 0.0 0.2 10.9 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM03931.1 - 0.032 14.8 0.7 0.09 13.4 0.7 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family HEAT_EZ PF13513.6 CCM03932.1 - 3.4e-24 84.9 22.3 2e-15 56.9 0.0 9.4 8 2 3 11 11 11 4 HEAT-like repeat HEAT PF02985.22 CCM03932.1 - 4.4e-19 66.9 13.7 2.3e-05 24.2 0.0 10.0 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.6 CCM03932.1 - 7.1e-16 58.4 0.1 0.0001 22.6 0.0 7.6 6 2 3 9 9 9 3 HEAT repeats Vac14_Fab1_bd PF12755.7 CCM03932.1 - 4.4e-09 36.8 0.0 0.04 14.5 0.1 5.0 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CCM03932.1 - 2.5e-06 27.6 0.1 0.36 10.9 0.0 4.4 4 2 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 DUF3437 PF11919.8 CCM03932.1 - 1.4e-05 24.9 0.1 0.41 10.6 0.0 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF3437) Tti2 PF10521.9 CCM03932.1 - 0.00071 19.2 0.4 1.5 8.3 0.0 3.9 3 2 1 4 4 4 2 Tti2 family Arm PF00514.23 CCM03932.1 - 0.00073 19.5 1.3 0.37 10.9 0.0 5.0 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat IBN_N PF03810.19 CCM03932.1 - 0.002 18.0 0.0 0.0075 16.2 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cohesin_HEAT PF12765.7 CCM03932.1 - 0.0033 17.7 0.4 8.4 6.8 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 CCM03932.1 - 0.0042 15.7 0.9 1.2 7.6 0.2 3.7 4 0 0 4 4 4 1 Adaptin N terminal region Ecm29 PF13001.7 CCM03932.1 - 0.005 15.6 0.0 2.6 6.6 0.0 2.5 2 0 0 2 2 2 2 Proteasome stabiliser RTP1_C1 PF10363.9 CCM03932.1 - 0.037 14.2 0.2 0.75 10.0 0.0 3.2 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 TAF6_C PF07571.13 CCM03932.1 - 0.16 12.3 0.0 12 6.2 0.0 3.0 2 1 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain RRM_1 PF00076.22 CCM03933.1 - 5.7e-28 96.5 2.7 7.4e-09 35.3 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCM03933.1 - 6.5e-05 22.7 0.0 2.6 7.9 0.0 3.8 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_3 PF08777.11 CCM03933.1 - 7.6e-05 22.7 0.1 0.18 11.9 0.1 2.6 2 0 0 2 2 2 2 RNA binding motif RRM_5 PF13893.6 CCM03933.1 - 0.00019 21.0 0.0 0.024 14.2 0.0 2.8 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM03933.1 - 0.06 13.5 0.0 1 9.6 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif Nup35_RRM_2 PF14605.6 CCM03933.1 - 0.16 12.0 0.0 7.1 6.7 0.1 3.3 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif Hydrolase_4 PF12146.8 CCM03934.1 - 2.2e-46 158.1 0.1 8.6e-46 156.1 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM03934.1 - 1.3e-10 42.3 0.3 1.6e-10 41.9 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCM03934.1 - 4.1e-07 29.9 0.1 6.2e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 CCM03934.1 - 0.014 15.5 0.0 0.031 14.4 0.0 1.5 2 0 0 2 2 2 0 Thioesterase domain Lipase_3 PF01764.25 CCM03934.1 - 0.025 14.5 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Peptidase_S9 PF00326.21 CCM03934.1 - 0.025 14.0 0.3 0.89 9.0 0.1 2.5 2 1 1 3 3 3 0 Prolyl oligopeptidase family DUF900 PF05990.12 CCM03934.1 - 0.027 14.0 0.1 0.11 12.0 0.1 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) AXE1 PF05448.12 CCM03934.1 - 0.33 9.6 1.3 0.54 8.9 0.1 1.9 3 0 0 3 3 3 0 Acetyl xylan esterase (AXE1) Clat_adaptor_s PF01217.20 CCM03935.1 - 2.8e-15 56.5 0.0 5e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Metallophos PF00149.28 CCM03935.1 - 2.2e-09 38.1 0.1 3.6e-09 37.4 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AP-5_subunit_s1 PF15001.6 CCM03935.1 - 0.036 14.1 0.1 0.061 13.3 0.1 1.3 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 N2227 PF07942.12 CCM03936.1 - 7.5e-67 225.4 0.0 1e-66 225.0 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 CCM03936.1 - 6e-05 22.9 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM03936.1 - 0.0045 17.7 0.0 0.015 16.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PI3K_1B_p101 PF10486.9 CCM03936.1 - 0.15 9.8 0.0 0.22 9.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SH3_1 PF00018.28 CCM03938.1 - 2e-10 40.1 0.1 3.9e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCM03938.1 - 3.6e-08 33.1 0.1 8.7e-08 31.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCM03938.1 - 0.00023 20.8 0.0 0.00066 19.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Bac_rhodopsin PF01036.18 CCM03940.1 - 3.3e-37 128.2 18.0 4.3e-37 127.8 18.0 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein TMEM208_SND2 PF05620.11 CCM03940.1 - 1.2 8.8 9.6 0.11 12.3 3.6 2.1 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Zn-ribbon_8 PF09723.10 CCM03942.1 - 0.0027 17.8 3.1 0.0042 17.2 3.1 1.3 1 0 0 1 1 1 1 Zinc ribbon domain zf-RRPl_C4 PF17026.5 CCM03942.1 - 0.0043 17.1 0.1 0.0048 17.0 0.1 1.2 1 0 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type zf-FPG_IleRS PF06827.14 CCM03942.1 - 0.011 15.5 0.4 0.022 14.6 0.4 1.5 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS HypA PF01155.19 CCM03942.1 - 0.018 15.1 0.6 0.021 14.8 0.6 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DpnI PF06044.12 CCM03942.1 - 0.033 13.8 0.2 0.033 13.8 0.2 1.1 1 0 0 1 1 1 0 Dam-replacing family zinc_ribbon_9 PF14369.6 CCM03942.1 - 0.038 14.2 2.7 0.1 12.9 2.7 1.8 1 1 0 1 1 1 0 zinc-ribbon zf-UDP PF14569.6 CCM03942.1 - 0.04 14.0 1.0 0.055 13.6 0.6 1.5 2 0 0 2 2 2 0 Zinc-binding RING-finger zinc-ribbons_6 PF07191.12 CCM03942.1 - 0.044 13.8 0.9 0.071 13.1 0.9 1.3 1 0 0 1 1 1 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.7 CCM03942.1 - 0.085 12.8 2.4 2.6 8.1 0.1 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 CCM03942.1 - 0.14 12.1 8.6 2 8.4 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain Cys_rich_KTR PF14205.6 CCM03942.1 - 0.65 9.9 0.1 0.65 9.9 0.1 2.2 1 1 0 2 2 2 0 Cysteine-rich KTR zf-DNL PF05180.12 CCM03942.1 - 3.9 7.5 6.7 29 4.7 6.7 2.0 1 1 0 1 1 1 0 DNL zinc finger Ank_2 PF12796.7 CCM03944.1 - 8.9e-15 55.1 0.2 1.1e-10 42.0 0.1 1.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM03944.1 - 1.8e-11 44.0 1.1 8.5e-05 22.8 0.4 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM03944.1 - 3.8e-10 39.1 0.2 0.00099 19.4 0.1 3.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 CCM03944.1 - 9.9e-10 38.8 0.3 0.0001 22.8 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CCM03944.1 - 1.7e-06 28.2 3.1 0.033 14.6 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Death PF00531.22 CCM03945.1 - 0.038 14.2 0.1 0.077 13.2 0.1 1.5 1 0 0 1 1 1 0 Death domain Mo-nitro_C PF06967.11 CCM03946.1 - 0.33 10.9 1.7 13 5.8 0.2 2.3 2 0 0 2 2 2 0 Mo-dependent nitrogenase C-terminus Sperm_act_pep PF08250.11 CCM03946.1 - 3 8.5 8.0 12 6.7 1.0 2.9 2 0 0 2 2 2 0 Sperm-activating peptides Cwf_Cwc_15 PF04889.12 CCM03947.1 - 5.1e-78 262.2 26.6 5.9e-78 262.0 26.6 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 CCM03947.1 - 0.0047 15.2 23.6 0.0059 14.9 23.6 1.0 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 CCM03947.1 - 0.04 13.3 24.7 0.054 12.9 24.7 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 CCM03947.1 - 0.39 10.0 25.4 0.52 9.6 25.4 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 CCM03947.1 - 1.7 6.8 18.2 2.3 6.4 18.2 1.3 1 0 0 1 1 1 0 CDC45-like protein MFAP1 PF06991.11 CCM03947.1 - 1.9 8.3 32.4 6.3 6.6 32.4 1.8 1 1 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing NOA36 PF06524.12 CCM03947.1 - 2 7.6 20.6 3 7.1 20.6 1.4 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 CCM03947.1 - 4.3 6.9 16.9 6.5 6.2 16.9 1.3 1 0 0 1 1 1 0 PPP4R2 CENP-I PF07778.11 CCM03947.1 - 7.4 5.2 4.9 8.6 4.9 4.1 1.5 1 1 1 2 2 2 0 Mis6 Aldedh PF00171.22 CCM03948.1 - 1.2e-117 393.3 4.0 1.4e-117 393.1 4.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family AAA_13 PF13166.6 CCM03948.1 - 0.1 11.2 0.1 0.14 10.8 0.1 1.1 1 0 0 1 1 1 0 AAA domain ADH_zinc_N_2 PF13602.6 CCM03949.1 - 4.3e-18 66.6 0.0 2.5e-17 64.2 0.0 2.3 2 2 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCM03949.1 - 2.5e-08 34.0 0.0 4.5e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM03949.1 - 0.0063 16.4 0.0 0.052 13.4 0.0 2.3 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CCM03949.1 - 0.038 13.9 0.0 0.12 12.3 0.0 1.8 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase Sugar_tr PF00083.24 CCM03950.1 - 9.2e-86 288.5 27.8 1.1e-85 288.3 27.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM03950.1 - 2.4e-27 95.8 60.2 5.8e-25 88.0 32.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCM03950.1 - 1e-08 34.2 23.6 1e-06 27.6 0.3 2.4 2 1 0 2 2 2 2 MFS/sugar transport protein Caps_synth_CapC PF14102.6 CCM03950.1 - 4 7.9 18.1 0.64 10.4 1.1 3.7 2 1 1 3 3 3 0 Capsule biosynthesis CapC SR-25 PF10500.9 CCM03951.1 - 0.00047 19.9 30.9 0.00047 19.9 30.9 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Pox_RNA_pol PF03293.14 CCM03951.1 - 0.13 12.0 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase, 18 kD subunit Menin PF05053.13 CCM03951.1 - 0.66 8.3 6.1 0.77 8.0 6.1 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.22 CCM03951.1 - 1.1 8.5 5.7 1.1 8.5 5.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 CCM03951.1 - 3.5 8.0 8.2 9.1 6.7 8.2 1.8 1 0 0 1 1 1 0 RNA polymerase III RPC4 ABC_tran PF00005.27 CCM03952.1 - 1.2e-47 161.8 0.0 1.8e-28 99.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCM03952.1 - 7.2e-45 153.8 33.3 1.4e-25 90.4 10.7 3.4 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 CCM03952.1 - 2.2e-11 43.6 4.8 0.0083 15.6 0.5 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM03952.1 - 1.7e-08 35.3 0.9 5.9e-05 23.7 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 CCM03952.1 - 1.6e-06 28.2 6.4 0.0099 15.7 0.2 4.7 4 1 0 5 5 5 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM03952.1 - 1.8e-06 27.6 0.3 0.021 14.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM03952.1 - 2.5e-05 24.7 2.1 0.22 11.9 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA_25 PF13481.6 CCM03952.1 - 7.2e-05 22.4 0.1 0.47 10.0 0.0 2.8 3 0 0 3 3 3 2 AAA domain T2SSE PF00437.20 CCM03952.1 - 8.4e-05 21.7 0.2 0.028 13.5 0.0 3.0 3 0 0 3 3 3 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 CCM03952.1 - 9e-05 22.5 0.2 0.19 11.8 0.0 3.0 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 CCM03952.1 - 0.00058 20.1 0.7 0.64 10.3 0.0 3.0 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CCM03952.1 - 0.00066 19.5 0.4 3 7.6 0.0 3.3 3 0 0 3 3 3 2 IstB-like ATP binding protein RsgA_GTPase PF03193.16 CCM03952.1 - 0.0011 18.9 0.1 0.85 9.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 CCM03952.1 - 0.0014 18.8 1.1 0.11 12.6 0.1 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 CCM03952.1 - 0.002 17.5 0.0 1 8.6 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family ATPase_2 PF01637.18 CCM03952.1 - 0.0051 16.7 0.0 0.35 10.7 0.0 2.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea DEAD PF00270.29 CCM03952.1 - 0.01 15.6 0.2 4.5 7.0 0.2 2.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase Adeno_IVa2 PF02456.15 CCM03952.1 - 0.015 14.1 0.2 0.31 9.8 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_7 PF12775.7 CCM03952.1 - 0.018 14.6 0.2 2.5 7.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_15 PF13175.6 CCM03952.1 - 0.033 13.9 0.2 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 CCM03952.1 - 0.038 14.0 0.9 9.4 6.2 0.1 3.4 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) SR-25 PF10500.9 CCM03952.1 - 0.041 13.5 2.8 0.09 12.4 2.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dynamin_N PF00350.23 CCM03952.1 - 0.051 13.6 0.1 5.8 6.9 0.0 2.8 3 0 0 3 3 2 0 Dynamin family ResIII PF04851.15 CCM03952.1 - 0.056 13.4 0.0 4 7.4 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Pox_A32 PF04665.12 CCM03952.1 - 0.058 12.8 0.5 10 5.5 0.0 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_11 PF13086.6 CCM03952.1 - 0.059 13.2 0.2 0.41 10.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 CCM03952.1 - 0.063 12.2 0.4 7.1 5.4 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 CCM03952.1 - 0.094 13.1 0.0 25 5.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 CCM03952.1 - 0.096 13.2 0.0 32 5.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CCM03952.1 - 0.17 12.1 0.1 18 5.6 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 CCM03952.1 - 0.23 11.1 2.8 0.72 9.4 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 CCM03952.1 - 0.23 11.9 3.0 2.9 8.3 0.0 3.4 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 CCM03952.1 - 0.24 10.2 3.0 7.3 5.3 0.2 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class NACHT PF05729.12 CCM03952.1 - 0.52 10.2 4.0 6.1 6.7 0.1 3.2 3 0 0 3 3 3 0 NACHT domain MobB PF03205.14 CCM03952.1 - 2.6 7.9 4.4 18 5.2 0.1 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B ABC2_membrane PF01061.24 CCM03954.1 - 3.8e-68 229.0 63.9 1.6e-39 135.5 13.6 3.9 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 CCM03954.1 - 1.4e-32 113.0 0.0 3e-15 56.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCM03954.1 - 7.1e-31 106.0 17.9 3.9e-29 100.4 0.2 4.5 5 0 0 5 5 5 2 CDR ABC transporter AAA_16 PF13191.6 CCM03954.1 - 2.6e-07 31.2 0.2 0.001 19.5 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CCM03954.1 - 4.4e-07 29.9 0.0 4.1e-05 23.6 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase ABC_trans_N PF14510.6 CCM03954.1 - 8e-07 29.6 0.0 1.7e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_22 PF13401.6 CCM03954.1 - 7.9e-06 26.2 0.0 0.023 15.0 0.0 3.1 2 1 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.7 CCM03954.1 - 1.4e-05 24.4 45.5 0.0026 16.9 22.9 2.9 2 2 0 2 2 2 2 ABC-2 family transporter protein AAA_18 PF13238.6 CCM03954.1 - 0.00016 22.2 0.0 0.022 15.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CCM03954.1 - 0.00025 21.1 0.0 0.71 10.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_25 PF13481.6 CCM03954.1 - 0.00051 19.7 0.0 0.04 13.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCM03954.1 - 0.00087 19.2 0.0 0.13 12.2 0.1 2.6 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 CCM03954.1 - 0.0011 19.1 0.1 0.15 12.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCM03954.1 - 0.0024 17.6 0.2 0.22 11.3 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CCM03954.1 - 0.0034 17.3 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system dNK PF01712.19 CCM03954.1 - 0.0054 16.6 0.0 0.024 14.5 0.0 2.0 2 0 0 2 2 2 1 Deoxynucleoside kinase SMC_N PF02463.19 CCM03954.1 - 0.012 15.1 0.0 0.14 11.6 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CCM03954.1 - 0.033 13.9 0.0 1.2 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CCM03954.1 - 0.042 13.4 0.1 1.7 8.2 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 CCM03954.1 - 0.067 13.2 0.1 0.62 10.1 0.1 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 CCM03954.1 - 0.09 12.5 0.0 4.9 6.9 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 CCM03954.1 - 0.11 12.7 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CCM03954.1 - 0.16 12.5 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain SNF2_N PF00176.23 CCM03956.1 - 6.6e-44 150.1 0.5 5e-43 147.2 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM03956.1 - 5.5e-17 62.1 0.0 1.2e-16 61.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CCM03956.1 - 5.8e-06 25.7 0.0 0.00017 20.9 0.0 2.8 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 CCM03956.1 - 6.3e-05 23.0 0.0 0.00016 21.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit YlbD_coat PF14071.6 CCM03956.1 - 0.014 15.6 1.9 0.039 14.2 1.9 1.7 1 0 0 1 1 1 0 Putative coat protein SWI2_SNF2 PF18766.1 CCM03956.1 - 0.023 14.4 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Kazal_3 PF18434.1 CCM03956.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DEAD PF00270.29 CCM03956.1 - 0.17 11.7 0.0 0.43 10.3 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase ITAM PF02189.15 CCM03956.1 - 0.62 10.6 0.0 0.62 10.6 0.0 2.2 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif F-box-like PF12937.7 CCM03957.1 - 4.1e-05 23.4 0.2 9e-05 22.3 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM03957.1 - 0.00015 21.6 0.3 0.00039 20.2 0.3 1.7 1 0 0 1 1 1 1 F-box domain Senescence PF06911.12 CCM03958.1 - 2.5e-11 44.2 11.8 1.5e-10 41.7 11.9 2.0 1 1 1 2 2 2 1 Senescence-associated protein I_LWEQ PF01608.17 CCM03958.1 - 2.4 8.4 4.7 5.5 7.2 0.4 2.6 1 1 2 3 3 3 0 I/LWEQ domain AA_permease_2 PF13520.6 CCM03960.1 - 9.8e-72 242.1 46.8 1.1e-71 241.9 46.8 1.0 1 0 0 1 1 1 1 Amino acid permease LIM_bind PF01803.16 CCM03961.1 - 3.2e-56 190.6 0.0 3.2e-56 190.6 0.0 3.2 4 0 0 4 4 4 1 LIM-domain binding protein HMG_box PF00505.19 CCM03962.1 - 1.7e-16 60.4 2.4 2.7e-16 59.7 2.4 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM03962.1 - 3.7e-08 33.8 1.7 6.7e-08 33.0 1.7 1.5 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 CCM03962.1 - 0.0011 18.9 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 CHDNT (NUC034) domain YABBY PF04690.13 CCM03962.1 - 0.004 17.7 2.7 0.012 16.2 0.1 2.1 2 0 0 2 2 2 1 YABBY protein CobT PF06213.12 CCM03962.1 - 0.16 11.4 9.9 1.8 7.9 7.4 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Wx5_PLAF3D7 PF09688.10 CCM03962.1 - 0.16 12.0 0.2 0.16 12.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) TLP-20 PF06088.11 CCM03962.1 - 0.78 9.6 4.5 1.3 8.9 4.5 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF913 PF06025.12 CCM03962.1 - 2.5 7.0 4.2 3.2 6.6 4.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 CCM03962.1 - 3.5 5.8 7.8 4.3 5.5 7.8 1.2 1 0 0 1 1 1 0 CDC45-like protein YqfQ PF14181.6 CCM03962.1 - 4.7 7.4 10.5 10 6.3 10.5 1.6 1 0 0 1 1 1 0 YqfQ-like protein WW PF00397.26 CCM03963.1 - 2.9e-07 30.5 5.3 7.6e-07 29.1 5.3 1.8 1 0 0 1 1 1 1 WW domain Yae1_N PF09811.9 CCM03963.1 - 0.1 12.3 0.2 0.1 12.3 0.2 1.8 2 0 0 2 2 2 0 Essential protein Yae1, N terminal MFS_1 PF07690.16 CCM03964.1 - 6.3e-33 114.1 27.3 9.8e-33 113.5 27.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_transf_8 PF01501.20 CCM03965.1 - 7e-28 97.9 0.0 2.3e-27 96.2 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 Methyltransf_24 PF13578.6 CCM03965.1 - 1.5e-17 64.5 0.1 6.2e-17 62.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Glyco_transf_24 PF18404.1 CCM03965.1 - 5.3e-05 22.8 0.0 0.0001 21.8 0.0 1.5 1 0 0 1 1 1 1 Glucosyltransferase 24 Methyltransf_3 PF01596.17 CCM03965.1 - 0.0043 16.2 0.0 0.0091 15.2 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase Epimerase PF01370.21 CCM03966.1 - 2.6e-40 138.4 0.0 3.7e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM03966.1 - 1e-20 74.5 0.0 2.4e-20 73.2 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCM03966.1 - 2.3e-12 46.5 0.0 3.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCM03966.1 - 4.6e-07 29.9 0.0 9.1e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCM03966.1 - 5.4e-05 22.5 0.0 0.0033 16.6 0.0 2.4 2 0 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 CCM03966.1 - 0.0008 18.6 0.0 0.0028 16.8 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 CCM03966.1 - 0.0031 17.1 0.0 0.0059 16.2 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CCM03966.1 - 0.019 14.1 0.0 0.28 10.3 0.1 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein adh_short PF00106.25 CCM03966.1 - 0.22 10.9 0.1 0.43 10.0 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Glycos_transf_2 PF00535.26 CCM03967.1 - 2.3e-13 50.3 0.1 3.3e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CCM03967.1 - 0.014 15.3 0.0 0.021 14.7 0.0 1.4 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CCM03967.1 - 0.19 11.2 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 SNF2_N PF00176.23 CCM03968.1 - 3.1e-55 187.3 0.1 3.5e-54 183.9 0.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM03968.1 - 6.4e-15 55.5 0.0 2.6e-14 53.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM03968.1 - 4.7e-06 26.7 0.0 9.8e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_2 PF13639.6 CCM03968.1 - 1.4e-05 25.3 5.1 1.4e-05 25.3 5.1 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 CCM03968.1 - 3e-05 23.8 5.3 3e-05 23.8 5.3 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 CCM03968.1 - 7.8e-05 22.5 0.0 0.00019 21.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-rbx1 PF12678.7 CCM03968.1 - 9.6e-05 22.6 2.0 0.00023 21.4 2.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CCM03968.1 - 0.00035 20.4 4.0 0.00035 20.4 4.0 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 CCM03968.1 - 0.0019 18.0 3.6 0.0046 16.8 3.6 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 CCM03968.1 - 0.0034 17.2 4.3 0.0034 17.2 4.3 1.9 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCM03968.1 - 0.0049 16.7 4.5 0.0049 16.7 4.5 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM03968.1 - 0.0077 16.2 0.1 0.0077 16.2 0.1 3.0 2 2 1 3 3 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CCM03968.1 - 0.017 15.2 0.3 0.041 13.9 0.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PEMT PF04191.13 CCM03969.1 - 9.5e-14 51.7 3.1 1.1e-12 48.3 0.8 3.0 2 1 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 CCM03969.1 - 2.2e-12 47.3 0.4 6.2e-12 45.8 0.0 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ERG4_ERG24 PF01222.17 CCM03969.1 - 0.00021 20.2 0.0 0.0005 19.0 0.0 1.6 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CCM03969.1 - 0.015 14.8 0.4 0.015 14.8 0.4 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1295) Acyl-CoA_dh_1 PF00441.24 CCM03970.1 - 5.7e-30 104.5 0.4 9e-30 103.9 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 CCM03970.1 - 3.9e-16 59.0 0.0 9.4e-16 57.7 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 CCM03970.1 - 7.6e-16 58.1 0.8 1.4e-15 57.2 0.3 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCM03970.1 - 1.8e-13 51.1 0.0 4.6e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCM03970.1 - 4.6e-05 23.7 0.1 0.0001 22.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain dCMP_cyt_deam_1 PF00383.23 CCM03971.1 - 1.5e-22 79.4 0.3 2e-22 79.0 0.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCM03971.1 - 1.8e-22 79.6 0.2 3.1e-22 78.8 0.2 1.3 1 1 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 CCM03971.1 - 0.00025 21.1 0.0 0.00042 20.4 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 CCM03971.1 - 0.00029 20.9 3.3 0.017 15.2 3.3 2.2 1 1 0 1 1 1 1 Bd3614-like deaminase NAD1 PF18778.1 CCM03971.1 - 0.003 17.7 0.0 0.0043 17.2 0.0 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 CCM03971.1 - 0.0066 16.5 0.0 0.0096 16.0 0.0 1.2 1 0 0 1 1 1 1 APOBEC2 APOBEC3 PF18771.1 CCM03971.1 - 0.011 15.9 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 APOBEC3 APOBEC_N PF08210.11 CCM03971.1 - 0.013 15.4 0.0 0.018 15.0 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain APOBEC1 PF18769.1 CCM03971.1 - 0.013 15.7 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 APOBEC1 NAD2 PF18782.1 CCM03971.1 - 0.053 13.6 0.0 0.076 13.1 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 APOBEC4_like PF18774.1 CCM03971.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Mito_carr PF00153.27 CCM03972.1 - 4.3e-65 215.7 1.3 1.1e-21 76.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_S9_N PF02897.15 CCM03973.1 - 3.3e-89 299.5 3.5 4.8e-89 299.0 3.5 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CCM03973.1 - 2.1e-51 174.4 0.0 5.4e-51 173.1 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family mIF3 PF14877.6 CCM03973.1 - 5e-06 26.3 2.1 0.00023 20.9 1.4 2.3 1 1 1 2 2 2 1 Mitochondrial translation initiation factor IF3_C PF00707.22 CCM03973.1 - 0.00016 21.6 0.1 0.00032 20.6 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain Abhydrolase_3 PF07859.13 CCM03973.1 - 0.0026 17.7 0.4 0.038 13.8 0.4 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF4811 PF16069.5 CCM03973.1 - 0.021 14.7 0.0 0.083 12.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4811) PPR_2 PF13041.6 CCM03974.1 - 4e-08 33.3 0.0 0.015 15.4 0.0 4.8 5 0 0 5 5 5 2 PPR repeat family PPR_3 PF13812.6 CCM03974.1 - 6.3e-05 23.0 0.0 0.0039 17.2 0.0 3.5 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR PF01535.20 CCM03974.1 - 7e-05 22.8 7.0 5.5 7.5 0.0 6.2 6 0 0 6 6 6 2 PPR repeat PPR_1 PF12854.7 CCM03974.1 - 0.00067 19.3 0.0 0.4 10.4 0.1 3.8 5 0 0 5 5 5 2 PPR repeat MIF4G_like_2 PF09090.11 CCM03975.1 - 1.8e-74 250.6 0.0 2.5e-74 250.1 0.0 1.2 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.11 CCM03975.1 - 7.8e-65 218.2 0.0 1.8e-64 217.1 0.0 1.6 1 0 0 1 1 1 1 MIF4G like UAA PF08449.11 CCM03976.1 - 3.5e-73 246.4 6.6 7.9e-33 113.9 0.4 3.2 3 0 0 3 3 3 3 UAA transporter family Cyclin_N PF00134.23 CCM03977.1 - 3.1e-12 46.3 0.0 5e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CCM03977.1 - 2.6e-10 40.9 0.1 8.7e-10 39.2 0.0 2.0 2 0 0 2 2 2 1 Cyclin SH3_1 PF00018.28 CCM03978.1 - 1.8e-13 49.9 0.1 3.3e-13 49.0 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCM03978.1 - 1.3e-12 47.4 0.2 2.2e-12 46.6 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCM03978.1 - 3.2e-10 39.5 0.0 5.9e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SSXT PF05030.12 CCM03978.1 - 0.0031 17.1 0.0 0.0077 15.8 0.0 1.7 1 0 0 1 1 1 1 SSXT protein (N-terminal region) Ribosomal_L2_C PF03947.18 CCM03979.1 - 2.9e-46 156.8 3.2 5e-46 156.0 3.2 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CCM03979.1 - 8.3e-16 57.7 0.1 2e-15 56.5 0.1 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain FGGY_C PF02782.16 CCM03980.1 - 1.6e-48 165.0 1.1 2.5e-48 164.5 1.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CCM03980.1 - 5.9e-20 71.9 0.2 2.7e-19 69.7 0.0 2.3 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 CCM03980.1 - 0.00024 20.7 1.3 0.48 9.9 0.1 2.6 1 1 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family AnmK PF03702.14 CCM03980.1 - 0.052 12.7 0.1 0.11 11.6 0.1 1.5 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase MreB_Mbl PF06723.13 CCM03980.1 - 0.1 11.4 0.1 0.27 10.0 0.1 1.7 1 0 0 1 1 1 0 MreB/Mbl protein Rop-like PF05082.13 CCM03980.1 - 0.11 12.4 0.1 0.33 10.8 0.1 1.8 1 0 0 1 1 1 0 Rop-like Cyclin_N PF00134.23 CCM03982.1 - 3e-05 23.8 0.1 4.4e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CCM03982.1 - 0.08 13.3 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Cyclin Cyclin_N PF00134.23 CCM03983.1 - 2.1e-08 34.0 0.6 3.2e-08 33.3 0.6 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain GABP-alpha PF11620.8 CCM03983.1 - 0.12 12.6 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 GA-binding protein alpha chain Ribosomal_S25 PF03297.15 CCM03984.1 - 9.4e-40 134.9 1.6 1.1e-39 134.7 1.6 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 CCM03984.1 - 0.0025 17.4 0.2 0.004 16.7 0.2 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AIPR PF10592.9 CCM03984.1 - 0.015 14.9 0.1 0.016 14.9 0.1 1.1 1 0 0 1 1 1 0 AIPR protein MarR PF01047.22 CCM03984.1 - 0.05 13.5 0.1 0.071 13.1 0.1 1.2 1 0 0 1 1 1 0 MarR family PRKCSH-like PF12999.7 CCM03985.1 - 4.7e-48 163.3 0.3 1.2e-47 161.9 0.1 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 CCM03985.1 - 3.8e-28 98.1 0.0 8.6e-28 97.0 0.0 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 CCM03985.1 - 1.2e-09 39.1 2.1 1.2e-09 39.1 2.1 2.1 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Kri1 PF05178.12 CCM03985.1 - 0.05 14.2 0.1 0.05 14.2 0.1 2.9 3 0 0 3 3 3 0 KRI1-like family CopK PF11525.8 CCM03985.1 - 0.17 11.5 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Copper resistance protein K SecD-TM1 PF13721.6 CCM03985.1 - 0.55 10.7 1.6 12 6.4 0.2 2.4 2 0 0 2 2 2 0 SecD export protein N-terminal TM region Ldl_recept_a PF00057.18 CCM03985.1 - 3.2 8.1 16.3 1.9 8.7 4.5 2.5 1 1 1 2 2 2 0 Low-density lipoprotein receptor domain class A DUF4140 PF13600.6 CCM03985.1 - 8.7 6.9 8.3 42 4.7 3.7 2.7 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Cyclin PF08613.11 CCM03987.1 - 3.5e-44 151.0 0.0 1.6e-43 148.8 0.0 2.1 2 0 0 2 2 2 1 Cyclin WD40 PF00400.32 CCM03988.1 - 3.2e-06 27.8 0.4 0.084 13.8 0.1 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat PTPRCAP PF15713.5 CCM03988.1 - 0.011 16.0 3.0 0.011 16.0 3.0 1.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated WD40 PF00400.32 CCM03989.1 - 1.5e-10 41.5 3.1 5.4e-07 30.2 1.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat SBD PF17882.1 CCM03989.1 - 0.038 13.8 0.3 8.3 6.3 0.0 2.3 1 1 1 2 2 2 0 OAA-family lectin sugar binding domain eIF2A PF08662.11 CCM03989.1 - 0.054 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 CCM03989.1 - 0.12 10.9 0.0 0.13 10.7 0.0 1.2 1 0 0 1 1 1 0 Cytochrome D1 heme domain IKI3 PF04762.12 CCM03989.1 - 0.15 10.0 0.0 0.24 9.3 0.0 1.3 1 1 0 1 1 1 0 IKI3 family Tti2 PF10521.9 CCM03990.1 - 3.7e-44 151.3 0.0 5.6e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 Tti2 family DUF3445 PF11927.8 CCM03992.1 - 2e-20 73.4 0.0 2.7e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) DUF3445 PF11927.8 CCM03993.1 - 2e-13 50.5 0.0 2.7e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) ADH_zinc_N_2 PF13602.6 CCM03994.1 - 0.0038 18.3 0.0 0.25 12.4 0.0 2.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase GN3L_Grn1 PF08701.11 CCM03995.1 - 1.2e-23 82.9 21.2 1.2e-23 82.9 21.2 3.1 3 1 0 3 3 2 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 CCM03995.1 - 6.9e-15 55.1 2.0 5e-13 49.1 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 CCM03995.1 - 1.2e-07 31.3 0.0 2.3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 CCM03995.1 - 1.2e-06 28.7 6.0 4.2e-06 26.9 0.4 3.2 2 1 1 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 CCM03995.1 - 1.4e-06 28.4 0.2 2.4e-05 24.3 0.3 2.2 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 CCM03995.1 - 0.0002 20.9 0.0 0.00096 18.7 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Septin PF00735.18 CCM03995.1 - 0.0038 16.6 0.0 0.0074 15.6 0.0 1.4 1 0 0 1 1 1 1 Septin SDA1 PF05285.12 CCM03995.1 - 0.0052 16.3 19.5 0.0052 16.3 19.5 2.5 2 1 0 2 2 1 1 SDA1 IIGP PF05049.13 CCM03995.1 - 0.028 13.5 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) SRPRB PF09439.10 CCM03995.1 - 0.034 13.6 0.1 0.082 12.3 0.1 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Spore_IV_A PF09547.10 CCM03995.1 - 0.058 12.3 0.0 0.36 9.7 0.0 1.9 1 1 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) AAA_16 PF13191.6 CCM03995.1 - 0.29 11.5 5.9 0.43 11.0 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CCM03995.1 - 0.53 9.6 2.7 0.87 8.9 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family HTH_42 PF06224.12 CCM03997.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain NAD_binding_10 PF13460.6 CCM03998.1 - 0.00011 22.2 0.0 0.00019 21.4 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding HAD_2 PF13419.6 CCM04000.1 - 8.6e-09 35.7 0.0 1e-05 25.7 0.0 2.1 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCM04000.1 - 0.00031 21.1 0.0 0.0006 20.2 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NUDIX PF00293.28 CCM04000.1 - 0.089 12.8 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 NUDIX domain NAD_binding_4 PF07993.12 CCM04001.1 - 4.6e-67 225.9 0.0 6.9e-67 225.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CCM04001.1 - 7.2e-64 215.9 0.0 1e-63 215.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CCM04001.1 - 7.3e-14 51.3 0.0 2.6e-13 49.4 0.0 1.9 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 CCM04001.1 - 3.5e-12 46.5 0.0 8.2e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 CCM04001.1 - 2.3e-08 33.8 0.0 4.5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04001.1 - 0.00016 20.8 0.0 0.00046 19.3 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 CCM04001.1 - 0.0002 22.3 0.0 0.0012 19.7 0.0 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DEAD PF00270.29 CCM04003.1 - 5.6e-38 130.4 0.0 2.6e-37 128.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM04003.1 - 3e-18 66.2 0.0 8.4e-18 64.7 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM04003.1 - 0.012 15.6 0.0 0.051 13.6 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit KH_1 PF00013.29 CCM04004.1 - 1.9e-06 27.6 0.1 6.1e-05 22.8 0.1 2.4 2 0 0 2 2 2 1 KH domain K_channel_TID PF07941.11 CCM04004.1 - 0.0023 18.3 5.5 0.0065 16.9 5.5 1.8 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain Trp_repressor PF01371.19 CCM04004.1 - 0.047 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Trp repressor protein CAP_N PF01213.19 CCM04004.1 - 0.43 10.0 18.2 0.87 9.0 6.0 2.5 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 CCM04004.1 - 8.6 6.4 10.4 10 6.1 3.3 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator 3Beta_HSD PF01073.19 CCM04005.1 - 2.9e-29 102.0 0.0 2.6e-28 98.8 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM04005.1 - 2.9e-14 52.9 0.0 1.1e-10 41.2 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein Epimerase PF01370.21 CCM04005.1 - 7.6e-12 45.2 0.0 5.6e-11 42.4 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCM04005.1 - 3.6e-06 26.3 0.0 4.2e-05 22.8 0.0 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CCM04005.1 - 1.1e-05 25.5 0.0 2.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCM04005.1 - 5.6e-05 22.7 0.2 0.00096 18.6 0.0 2.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCM04005.1 - 0.00011 22.1 0.0 0.00077 19.4 0.0 2.3 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CCM04005.1 - 0.0017 17.9 0.0 2 7.8 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase RmlD_sub_bind PF04321.17 CCM04005.1 - 0.028 13.5 0.0 0.13 11.3 0.0 1.9 1 1 0 1 1 1 0 RmlD substrate binding domain CTP_synth_N PF06418.14 CCM04006.1 - 4.3e-92 308.2 0.3 3.9e-78 262.4 0.1 2.1 1 1 1 2 2 2 2 CTP synthase N-terminus GATase PF00117.28 CCM04006.1 - 3.2e-49 167.3 0.0 4.9e-49 166.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCM04006.1 - 0.073 12.8 0.1 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 Peptidase C26 ADH_N PF08240.12 CCM04007.1 - 4.8e-29 100.4 1.6 1.1e-28 99.3 1.6 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM04007.1 - 3.1e-12 46.6 0.0 6.2e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CCM04007.1 - 2.8e-11 43.3 0.1 8.4e-11 41.8 0.1 1.7 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CCM04007.1 - 4.9e-06 27.6 0.0 9.6e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 CCM04007.1 - 5.2e-05 22.7 0.5 7.8e-05 22.1 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM04007.1 - 0.015 14.6 0.1 0.095 11.9 0.1 2.2 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CCM04007.1 - 0.038 14.4 0.0 0.071 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_8 PF13450.6 CCM04007.1 - 0.041 14.1 0.6 0.19 11.9 0.3 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCM04007.1 - 0.049 14.2 0.1 5.9 7.5 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CCM04007.1 - 0.062 13.4 0.3 0.17 12.0 0.3 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CCM04007.1 - 0.074 13.3 0.0 0.17 12.1 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain ADH_N_assoc PF13823.6 CCM04007.1 - 0.11 12.4 0.2 0.32 11.0 0.2 1.8 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated NAD_binding_3 PF03447.16 CCM04007.1 - 0.12 13.0 0.0 0.52 11.0 0.0 2.0 1 1 1 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Lgl_C PF08596.10 CCM04007.1 - 0.17 10.6 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal DUF2512 PF10710.9 CCM04008.1 - 0.041 13.5 0.2 0.041 13.5 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) TauE PF01925.19 CCM04008.1 - 4.2 6.9 12.5 8.1 6.0 12.5 1.5 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE OST3_OST6 PF04756.13 CCM04008.1 - 4.8 6.4 5.6 0.57 9.5 0.5 2.0 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family WD40 PF00400.32 CCM04009.1 - 5.4e-17 61.9 11.9 0.0059 17.4 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04009.1 - 7.4e-06 26.2 2.9 0.06 13.7 0.1 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM04009.1 - 0.0034 16.4 0.0 6.1 5.7 0.0 3.6 4 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4064 PF13273.6 CCM04010.1 - 0.036 14.3 0.1 0.061 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) VGCC_beta4Aa_N PF12052.8 CCM04010.1 - 0.62 10.2 4.2 0.36 11.0 0.4 2.3 2 0 0 2 2 2 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal JTB PF05439.12 CCM04012.1 - 2.3e-05 24.4 0.2 2.3e-05 24.4 0.2 1.5 2 0 0 2 2 2 1 Jumping translocation breakpoint protein (JTB) SRP19 PF01922.17 CCM04013.1 - 1.1e-22 80.8 0.0 2.2e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 SRP19 protein DUF4680 PF15730.5 CCM04013.1 - 6.8 7.0 8.7 15 5.9 6.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) F-box-like PF12937.7 CCM04016.1 - 1.3e-10 41.0 0.7 9.3e-10 38.3 0.6 2.4 2 0 0 2 2 2 1 F-box-like Hexokinase_2 PF03727.16 CCM04017.1 - 1.9e-74 250.1 0.0 3.7e-73 245.9 0.0 2.1 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CCM04017.1 - 6.8e-71 238.3 0.0 9.3e-71 237.8 0.0 1.2 1 0 0 1 1 1 1 Hexokinase UPF0270 PF06794.12 CCM04017.1 - 0.0015 18.5 0.0 0.0041 17.2 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0270) Mt_ATP-synt_D PF05873.12 CCM04018.1 - 1.1e-15 57.8 3.3 1.3e-15 57.6 3.3 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DUF4047 PF13256.6 CCM04018.1 - 0.015 15.5 0.8 0.023 14.9 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) Prominin PF05478.11 CCM04018.1 - 0.015 13.3 0.2 0.017 13.1 0.2 1.0 1 0 0 1 1 1 0 Prominin GAS PF13851.6 CCM04018.1 - 0.058 12.7 2.7 0.081 12.3 2.7 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding EF-hand_1 PF00036.32 CCM04019.1 - 6.1e-28 94.3 11.5 2.4e-08 33.0 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CCM04019.1 - 1.5e-23 83.0 4.1 6.3e-13 49.0 1.1 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCM04019.1 - 5.8e-22 75.7 7.0 4.4e-05 23.1 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CCM04019.1 - 4.8e-19 66.9 14.6 3.4e-06 26.3 0.4 4.6 4 1 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CCM04019.1 - 7.2e-13 48.2 13.0 0.00017 21.4 0.4 4.3 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CCM04019.1 - 5.8e-06 26.6 0.0 0.028 14.7 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CCM04019.1 - 3e-05 23.9 5.7 0.012 15.6 0.5 3.8 1 1 3 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CCM04019.1 - 0.02 15.2 0.0 3.9 7.9 0.0 3.0 2 1 1 3 3 3 0 EF-hand domain PMBR PF09373.10 CCM04019.1 - 0.088 13.0 0.0 4 7.8 0.0 2.5 2 0 0 2 2 2 0 Pseudomurein-binding repeat Dockerin_1 PF00404.18 CCM04019.1 - 0.81 9.9 3.4 19 5.6 1.5 3.3 2 2 1 3 3 3 0 Dockerin type I domain MnmE_helical PF12631.7 CCM04020.1 - 1.4e-47 162.6 0.1 1.8e-47 162.2 0.1 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 CCM04020.1 - 2.3e-34 118.2 0.0 6.2e-34 116.8 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CCM04020.1 - 3.9e-19 68.8 0.0 1.4e-18 67.0 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCM04020.1 - 2.4e-06 27.7 0.0 0.00026 21.1 0.0 2.8 2 1 1 3 3 3 1 Dynamin family FeoB_N PF02421.18 CCM04020.1 - 8.6e-05 22.1 0.0 0.00015 21.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCM04020.1 - 0.006 16.5 0.0 0.35 10.8 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase HEAT_EZ PF13513.6 CCM04020.1 - 0.034 14.7 0.2 3.7 8.2 0.1 2.9 2 0 0 2 2 2 0 HEAT-like repeat ABC_tran PF00005.27 CCM04020.1 - 0.043 14.3 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 CCM04020.1 - 0.066 13.5 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Adap_comp_sub PF00928.21 CCM04021.1 - 8.9e-53 179.3 0.0 1.2e-52 179.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCM04021.1 - 0.00036 20.5 0.0 0.00072 19.5 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Sod_Fe_C PF02777.18 CCM04022.1 - 8e-17 61.3 0.0 9.7e-10 38.5 0.0 2.2 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain DAD PF02109.16 CCM04023.1 - 6.6e-48 161.5 1.4 7.3e-48 161.4 1.4 1.0 1 0 0 1 1 1 1 DAD family DUF1748 PF08520.10 CCM04024.1 - 4.2e-26 90.6 0.0 4.6e-26 90.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) PP-binding PF00550.25 CCM04024.1 - 0.051 13.9 0.0 0.067 13.6 0.0 1.1 1 0 0 1 1 1 0 Phosphopantetheine attachment site Isochorismatase PF00857.20 CCM04025.1 - 2.6e-12 47.3 0.0 3.4e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family ATG16 PF08614.11 CCM04026.1 - 0.003 17.8 13.4 0.053 13.8 13.4 2.7 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) CCDC158 PF15921.5 CCM04026.1 - 0.0061 14.5 4.1 0.011 13.7 4.1 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 158 Rootletin PF15035.6 CCM04026.1 - 0.053 13.5 8.1 0.011 15.7 4.3 1.8 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion TolA_bind_tri PF16331.5 CCM04026.1 - 0.13 12.4 1.9 1.1 9.3 0.0 2.7 2 0 0 2 2 2 0 TolA binding protein trimerisation IFT20 PF14931.6 CCM04026.1 - 0.4 10.9 6.5 0.13 12.5 1.5 2.7 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Spc7 PF08317.11 CCM04026.1 - 0.57 9.0 10.6 1.4 7.8 10.6 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.8 CCM04026.1 - 1.1 9.6 12.7 54 4.1 11.5 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 CCM04026.1 - 1.1 9.3 8.5 0.21 11.7 4.4 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 CCM04026.1 - 1.4 9.2 9.3 4 7.7 7.2 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HrpB7 PF09486.10 CCM04026.1 - 2 8.8 14.0 2.6 8.4 6.8 3.1 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) LRS4 PF10422.9 CCM04026.1 - 3.9 7.0 18.4 0.92 9.0 2.0 4.0 3 0 0 3 3 3 0 Monopolin complex subunit LRS4 CENP-F_leu_zip PF10473.9 CCM04026.1 - 5.6 7.0 20.9 3.3 7.7 1.7 3.5 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fungal_trans PF04082.18 CCM04027.1 - 4.1e-11 42.4 0.1 6.9e-11 41.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain TPR_1 PF00515.28 CCM04028.1 - 9.5e-50 164.5 20.6 2.9e-07 30.0 0.2 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 CCM04028.1 - 2.2e-43 142.9 21.9 9.4e-06 25.4 0.1 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat STI1 PF17830.1 CCM04028.1 - 8.8e-35 118.4 10.6 1.3e-17 63.4 0.2 3.2 3 0 0 3 3 2 2 STI1 domain TPR_8 PF13181.6 CCM04028.1 - 3.1e-28 95.6 14.8 0.0002 21.3 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.6 CCM04028.1 - 4e-27 93.6 22.0 8.8e-10 38.1 0.1 7.6 6 2 1 7 7 7 5 TPR repeat TPR_16 PF13432.6 CCM04028.1 - 7e-25 87.4 21.0 3.9e-08 33.8 0.1 7.0 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 CCM04028.1 - 2.4e-22 79.2 10.4 2.5e-07 31.1 0.1 7.1 5 2 3 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCM04028.1 - 1.5e-21 75.2 14.7 0.036 14.9 0.0 9.4 4 3 5 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 CCM04028.1 - 4e-21 75.1 19.6 4.4e-11 42.9 0.0 7.4 6 1 2 8 8 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 CCM04028.1 - 5.3e-20 70.3 3.0 0.00042 20.5 0.1 7.4 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CCM04028.1 - 6.5e-18 63.4 10.5 0.00076 19.3 0.0 8.0 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 CCM04028.1 - 2.3e-11 43.2 18.2 0.012 15.4 0.0 9.6 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCM04028.1 - 2.9e-11 43.4 7.9 3.8e-05 23.8 0.1 5.5 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 CCM04028.1 - 3.8e-09 36.6 20.1 1.7 9.4 0.1 9.1 9 1 0 9 9 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM04028.1 - 3.8e-06 27.0 7.1 0.07 13.4 0.1 5.6 2 2 3 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 CCM04028.1 - 0.00029 20.9 0.1 1.1 9.7 0.0 4.8 4 0 0 4 4 4 1 PPR repeat NARP1 PF12569.8 CCM04028.1 - 0.0075 15.2 1.1 0.0075 15.2 1.1 4.1 3 3 3 6 6 6 1 NMDA receptor-regulated protein 1 TPR_MalT PF17874.1 CCM04028.1 - 0.0096 15.3 0.3 0.3 10.4 0.0 2.8 1 1 1 2 2 2 1 MalT-like TPR region TPR_3 PF07720.12 CCM04028.1 - 0.032 14.2 16.1 0.17 11.9 0.1 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat HTH_24 PF13412.6 CCM04028.1 - 0.08 12.5 0.2 8.1 6.1 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TPR_20 PF14561.6 CCM04028.1 - 0.15 12.4 15.8 12 6.4 0.1 5.4 3 2 2 5 5 5 0 Tetratricopeptide repeat SPO22 PF08631.10 CCM04028.1 - 0.19 11.2 3.6 3.1 7.2 0.0 3.9 3 1 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like PPR_2 PF13041.6 CCM04028.1 - 0.21 11.8 0.1 7.5 6.8 0.0 3.1 3 0 0 3 3 3 0 PPR repeat family MAS20 PF02064.15 CCM04028.1 - 0.25 11.5 6.1 2.4 8.3 0.1 4.1 4 1 0 4 4 4 0 MAS20 protein import receptor XPC-binding PF09280.11 CCM04028.1 - 0.25 11.1 7.0 2.9 7.7 0.6 2.7 2 0 0 2 2 2 0 XPC-binding domain TMA7 PF09072.10 CCM04028.1 - 1.8 9.5 9.1 7.9 7.4 5.7 3.3 2 0 0 2 2 2 0 Translation machinery associated TMA7 RPN7 PF10602.9 CCM04028.1 - 3.7 7.2 16.2 13 5.4 0.5 5.3 4 2 2 6 6 5 0 26S proteasome subunit RPN7 Aldo_ket_red PF00248.21 CCM04029.1 - 5.1e-36 124.4 0.0 6.4e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Nup160 PF11715.8 CCM04030.1 - 1e-27 97.0 0.0 1.9e-27 96.1 0.0 1.4 1 1 0 1 1 1 1 Nucleoporin Nup120/160 B12D PF06522.11 CCM04030.1 - 8.3e-16 57.5 0.2 4.1e-14 52.1 0.1 2.6 2 0 0 2 2 2 1 NADH-ubiquinone reductase complex 1 MLRQ subunit TPR_4 PF07721.14 CCM04030.1 - 0.12 13.0 1.4 1.5 9.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCM04030.1 - 1.3 9.8 4.4 1.4 9.6 0.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Cyt-b5 PF00173.28 CCM04032.1 - 2.2e-10 40.6 0.1 3.7e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RGS PF00615.19 CCM04033.1 - 9.9e-39 132.3 0.2 2.8e-38 130.8 0.2 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 CCM04033.1 - 2.8e-14 52.9 0.0 2.1e-06 27.7 0.0 3.4 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) HTH_45 PF14947.6 CCM04033.1 - 0.12 12.4 0.1 4.6 7.3 0.0 2.9 3 0 0 3 3 3 0 Winged helix-turn-helix Glyoxalase PF00903.25 CCM04033.1 - 0.16 12.2 0.0 2.2 8.5 0.0 2.6 2 2 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF2458 PF10454.9 CCM04035.1 - 9.6e-06 25.4 2.3 1.7e-05 24.6 2.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) DGCR6 PF07324.11 CCM04035.1 - 0.015 15.0 1.1 0.02 14.5 1.1 1.2 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein GDP_Man_Dehyd PF16363.5 CCM04036.1 - 2.5e-61 207.9 0.0 3e-61 207.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCM04036.1 - 2e-46 158.4 0.0 2.7e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04036.1 - 7.6e-10 38.3 0.0 1.1e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM04036.1 - 8.7e-08 31.6 0.1 0.00065 18.9 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CCM04036.1 - 2.3e-06 26.9 0.1 0.0013 18.0 0.1 2.8 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCM04036.1 - 7.9e-06 25.2 0.0 1.1e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 CCM04036.1 - 0.21 11.0 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Bystin PF05291.11 CCM04037.1 - 9.3e-120 399.3 0.0 2e-108 362.1 0.0 2.1 2 0 0 2 2 2 2 Bystin PUF PF00806.19 CCM04038.1 - 2.2e-20 71.1 0.0 6.9e-06 25.5 0.0 7.7 8 0 0 8 8 8 5 Pumilio-family RNA binding repeat SAD_SRA PF02182.17 CCM04038.1 - 0.042 13.5 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 SAD/SRA domain ATP_bind_3 PF01171.20 CCM04039.1 - 6.6e-18 65.1 0.0 1.8e-17 63.7 0.0 1.7 2 0 0 2 2 2 1 PP-loop family zn-ribbon_14 PF16503.5 CCM04039.1 - 8.2e-15 54.0 3.7 8.2e-15 54.0 3.7 3.4 4 0 0 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 CCM04039.1 - 0.02 15.4 1.2 0.02 15.4 1.2 2.6 3 0 0 3 3 3 0 CHY zinc finger tRNA_Me_trans PF03054.16 CCM04039.1 - 0.039 12.8 0.0 0.064 12.0 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase DUF2616 PF11077.8 CCM04039.1 - 1.9 8.2 7.1 1.1 8.9 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) Na_H_Exchanger PF00999.21 CCM04040.1 - 6.7e-55 186.4 23.1 8.5e-55 186.1 23.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DS PF01916.17 CCM04041.1 - 4.9e-137 455.9 0.0 5.7e-137 455.7 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase G-7-MTase PF12803.7 CCM04041.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Sec7 PF01369.20 CCM04042.1 - 8.4e-73 244.0 0.4 2.7e-72 242.3 0.4 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CCM04042.1 - 2.2e-46 157.6 5.2 2.2e-46 157.6 5.2 3.2 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 CCM04042.1 - 1.5e-35 120.9 8.4 2.1e-34 117.2 0.1 5.6 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) DCB PF16213.5 CCM04042.1 - 7e-22 77.9 9.0 2.6e-20 72.8 0.4 4.1 4 0 0 4 4 4 2 Dimerisation and cyclophilin-binding domain of Mon2 HEAT PF02985.22 CCM04042.1 - 0.069 13.4 0.3 7.2 7.2 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat Cas_APE2256 PF09651.10 CCM04042.1 - 0.095 12.6 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) DUF1720 PF08226.11 CCM04043.1 - 0.19 12.1 80.5 1.8e+04 -33.7 80.5 4.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1720) SH3_1 PF00018.28 CCM04044.1 - 3.2e-37 125.9 6.2 3.6e-15 55.3 0.1 3.4 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 CCM04044.1 - 4.4e-36 122.5 11.9 4.4e-13 48.9 0.4 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 CCM04044.1 - 4.5e-25 87.1 0.0 3.6e-08 33.0 0.0 3.8 4 0 0 4 4 4 3 Variant SH3 domain SH3_3 PF08239.11 CCM04044.1 - 2.6e-07 30.8 2.8 0.25 11.7 0.1 3.4 3 0 0 3 3 3 3 Bacterial SH3 domain hSH3 PF14603.6 CCM04044.1 - 6e-05 23.4 0.0 0.23 11.9 0.0 3.4 2 1 1 3 3 3 1 Helically-extended SH3 domain SH3_10 PF17902.1 CCM04044.1 - 0.0011 19.0 0.0 0.34 11.0 0.0 3.1 3 0 0 3 3 3 1 SH3 domain GTP_EFTU PF00009.27 CCM04045.1 - 5.5e-46 156.6 0.1 8.5e-46 155.9 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CCM04045.1 - 5.9e-34 116.7 0.2 8.5e-33 113.0 0.1 2.7 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCM04045.1 - 1.2e-10 41.7 0.1 3.2e-10 40.3 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCM04045.1 - 0.0049 16.9 0.1 0.032 14.3 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CCM04045.1 - 0.031 13.6 0.0 0.28 10.5 0.0 2.3 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region PAM2 PF07145.15 CCM04045.1 - 0.12 12.1 1.4 0.21 11.4 0.1 2.1 2 0 0 2 2 2 0 Ataxin-2 C-terminal region Ndc1_Nup PF09531.10 CCM04045.1 - 3.1 6.4 4.3 4.1 6.0 4.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 CCM04045.1 - 8.4 5.5 7.3 13 4.9 7.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein 14-3-3 PF00244.20 CCM04046.1 - 7.6e-73 244.7 2.8 8.7e-73 244.5 2.8 1.0 1 0 0 1 1 1 1 14-3-3 protein Aldo_ket_red PF00248.21 CCM04047.1 - 5.9e-52 176.7 0.1 9.6e-50 169.4 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DUF2052 PF09747.9 CCM04048.1 - 3.9e-06 27.2 18.7 2.3e-05 24.6 18.7 2.0 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) DUF676 PF05057.14 CCM04049.1 - 6.6e-08 32.3 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CCM04049.1 - 1.5e-05 25.8 5.1 2.4e-05 25.1 5.2 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 CCM04049.1 - 0.00025 20.9 0.0 0.00044 20.1 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 CCM04049.1 - 0.0019 17.9 0.2 0.0043 16.8 0.1 1.6 1 1 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 CCM04049.1 - 0.0026 17.1 0.0 0.5 9.6 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 CCM04049.1 - 0.0084 15.8 0.2 0.15 11.7 0.1 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CCM04049.1 - 0.01 15.7 0.2 0.017 14.9 0.2 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 CCM04049.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 CCM04049.1 - 0.013 14.7 1.4 0.035 13.4 0.1 2.0 2 1 0 3 3 3 0 Serine aminopeptidase, S33 DUF900 PF05990.12 CCM04049.1 - 0.097 12.2 0.0 0.63 9.5 0.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Acetyltransf_1 PF00583.25 CCM04050.1 - 4.3e-13 49.5 0.0 5.2e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM04050.1 - 1e-09 38.4 0.2 1.2e-09 38.2 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM04050.1 - 2e-07 31.3 0.0 2.8e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM04050.1 - 5.6e-06 26.2 0.1 7.4e-06 25.8 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 CCM04050.1 - 0.0056 16.2 0.5 0.011 15.2 0.5 1.6 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_3 PF13302.7 CCM04050.1 - 0.0091 16.7 0.1 0.024 15.3 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCM04050.1 - 0.012 15.7 0.1 0.015 15.4 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LRR_4 PF12799.7 CCM04051.1 - 2.6e-12 46.8 14.2 0.16 12.4 0.2 7.9 7 1 1 8 8 8 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 CCM04051.1 - 1.3e-09 37.8 5.4 1.6e-09 37.5 2.7 2.5 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 CCM04051.1 - 1.5e-05 24.7 20.6 21 5.5 0.0 11.0 12 0 0 12 12 12 1 Leucine Rich repeat SAM_Ste50p PF09235.10 CCM04051.1 - 4.8 7.5 14.1 37 4.7 0.0 5.5 5 2 1 6 6 6 0 Ste50p, sterile alpha motif LRR_1 PF00560.33 CCM04051.1 - 7.8 7.5 11.3 1.2e+02 3.9 0.1 7.1 9 0 0 9 9 9 0 Leucine Rich Repeat F-box PF00646.33 CCM04051.1 - 8.3 6.4 10.8 0.12 12.3 0.8 3.1 3 0 0 3 3 3 0 F-box domain DUF4050 PF13259.6 CCM04052.1 - 0.003 17.9 0.0 0.034 14.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) LSM PF01423.22 CCM04053.1 - 1.4e-19 69.5 0.1 1.6e-19 69.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain zf-U1 PF06220.12 CCM04054.1 - 2e-20 72.2 4.1 2.8e-20 71.8 4.1 1.2 1 0 0 1 1 1 1 U1 zinc finger CLIP1_ZNF PF16641.5 CCM04054.1 - 0.12 12.3 1.5 0.2 11.6 1.5 1.4 1 0 0 1 1 1 0 CLIP1 zinc knuckle Sua5_yciO_yrdC PF01300.18 CCM04055.1 - 4.5e-51 172.9 0.0 8.6e-51 172.0 0.0 1.5 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 CCM04055.1 - 8.8e-30 104.0 0.0 2e-29 102.9 0.0 1.6 2 0 0 2 2 2 1 Putative GTP-binding controlling metal-binding DEAD PF00270.29 CCM04056.1 - 7.6e-37 126.8 0.0 1.5e-36 125.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM04056.1 - 8.5e-24 84.0 0.0 2.2e-23 82.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM04056.1 - 0.0094 16.0 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mob1_phocein PF03637.17 CCM04058.1 - 3.4e-78 261.5 0.0 3.9e-78 261.3 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family DJ-1_PfpI PF01965.24 CCM04059.1 - 2.6e-13 50.1 0.0 4.9e-13 49.2 0.0 1.4 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CCM04059.1 - 1.5e-05 24.8 0.0 3.4e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 ThiJ/PfpI family-like Endotoxin_C2 PF18449.1 CCM04059.1 - 0.074 13.4 0.3 0.16 12.3 0.3 1.5 1 0 0 1 1 1 0 Delta endotoxin RRM_1 PF00076.22 CCM04060.1 - 2.9e-18 65.4 0.1 7.9e-08 32.0 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCM04060.1 - 0.0005 19.7 0.0 0.004 16.7 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCM04060.1 - 0.0039 17.0 0.0 0.11 12.4 0.0 2.6 2 1 0 2 2 2 1 Occluded RNA-recognition motif Tim54 PF11711.8 CCM04060.1 - 0.0059 15.4 0.3 0.0088 14.9 0.3 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 RRN3 PF05327.11 CCM04060.1 - 0.27 9.7 5.3 0.36 9.3 5.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FYDLN_acid PF09538.10 CCM04060.1 - 0.29 11.8 10.5 0.51 11.1 10.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 CCM04060.1 - 1.2 7.2 10.4 1.6 6.7 10.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRAM_LAG1_CLN8 PF03798.16 CCM04061.1 - 8.9e-43 146.3 26.4 1.2e-42 146.0 26.4 1.1 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 CCM04061.1 - 1.2e-09 37.7 5.0 2.5e-08 33.5 0.0 3.4 3 0 0 3 3 3 2 TRAM1-like protein HemY_N PF07219.13 CCM04061.1 - 0.49 10.6 4.0 13 6.0 0.0 3.4 3 0 0 3 3 3 0 HemY protein N-terminus Snf7 PF03357.21 CCM04062.1 - 4e-35 120.9 14.2 4e-35 120.9 14.2 1.3 2 0 0 2 2 2 1 Snf7 DUF3135 PF11333.8 CCM04062.1 - 0.085 13.1 3.0 3.9 7.8 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3135) DUF1319 PF07028.11 CCM04062.1 - 0.14 12.4 3.7 4.9 7.4 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1319) DUF3138 PF11336.8 CCM04062.1 - 0.27 9.8 3.3 0.37 9.3 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF1690 PF07956.11 CCM04062.1 - 4.4 7.7 17.2 1.9 8.9 9.8 2.3 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) NIF PF03031.18 CCM04063.1 - 2.8e-51 173.4 0.0 3.6e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Mannosidase_ig PF17786.1 CCM04064.1 - 1.5e-16 60.7 0.0 5.3e-16 59.0 0.0 2.0 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CCM04064.1 - 3.8e-08 34.0 0.0 8.9e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 CCM04064.1 - 3e-05 24.0 0.1 0.00013 22.0 0.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 CCM04064.1 - 0.00019 21.1 0.0 0.0011 18.7 0.0 2.2 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2_C PF02836.17 CCM04064.1 - 0.011 14.8 0.1 0.11 11.6 0.1 2.1 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain DUF2563 PF10817.8 CCM04064.1 - 0.16 12.6 0.0 0.32 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2563) Ras PF00071.22 CCM04065.1 - 1.6e-46 157.8 0.6 1.9e-46 157.7 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM04065.1 - 2.7e-15 56.7 0.0 4.2e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM04065.1 - 1.9e-07 30.7 0.0 2.3e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM04065.1 - 2.3e-05 24.1 0.5 8.3e-05 22.2 0.3 1.7 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCM04065.1 - 0.00041 20.4 0.0 0.00074 19.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM04065.1 - 0.0037 17.2 0.3 1.8 8.4 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 CCM04065.1 - 0.0076 15.7 0.1 0.0089 15.5 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 CCM04065.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Spo12 PF05032.12 CCM04066.1 - 2.2e-14 53.0 5.6 4.1e-14 52.2 5.6 1.5 1 0 0 1 1 1 1 Spo12 family SOG2 PF10428.9 CCM04066.1 - 0.66 9.1 7.2 0.72 9.0 7.2 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Chitin_synth_1 PF01644.17 CCM04067.1 - 6.2e-65 218.1 0.0 9.7e-65 217.5 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCM04067.1 - 9.9e-30 102.3 0.1 1.9e-29 101.4 0.1 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCM04067.1 - 3.8e-24 85.2 0.1 1.4e-18 66.8 0.0 2.3 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CCM04067.1 - 3.4e-08 33.6 5.2 1.8e-07 31.3 4.6 2.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Terpene_synth_C PF03936.16 CCM04069.1 - 0.00014 21.3 0.0 0.00022 20.7 0.0 1.3 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain TRI5 PF06330.11 CCM04069.1 - 0.045 12.6 0.1 0.084 11.7 0.1 1.3 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) Terpene_synth_C PF03936.16 CCM04071.1 - 1.9e-06 27.4 0.0 2.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain p450 PF00067.22 CCM04072.1 - 3.6e-62 210.6 0.0 4.9e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCM04074.1 - 1.7e-12 47.2 0.3 2e-12 47.0 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04074.1 - 2.7e-05 23.9 0.1 2.9e-05 23.7 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF829 PF05705.14 CCM04076.1 - 1.7e-33 116.5 0.0 4e-33 115.3 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Acyl-CoA_dh_M PF02770.19 CCM04077.1 - 0.013 15.7 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CCM04077.1 - 0.043 14.0 3.7 0.1 12.8 3.7 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain p450 PF00067.22 CCM04078.1 - 7.1e-63 213.0 0.0 1.9e-45 155.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 MFS_1 PF07690.16 CCM04080.1 - 7e-37 127.2 55.6 7e-37 127.2 55.6 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM04080.1 - 6e-22 77.8 24.7 1e-21 77.1 24.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM04080.1 - 1.3e-15 57.3 14.7 1.3e-15 57.3 14.7 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter DUF3925 PF13063.6 CCM04080.1 - 0.38 11.0 4.7 1.8 8.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3925) HlyIII PF03006.20 CCM04080.1 - 0.65 9.7 16.0 0.078 12.7 5.0 3.1 1 1 2 3 3 3 0 Haemolysin-III related DUF5337 PF17272.2 CCM04080.1 - 6.4 6.7 9.7 0.36 10.7 2.9 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5337) DUF1230 PF06799.11 CCM04081.1 - 0.25 11.4 2.1 0.28 11.3 1.0 1.7 2 1 0 2 2 2 0 Conserved in the green lineage and diatoms 27 adh_short PF00106.25 CCM04082.1 - 4.9e-42 143.6 0.2 7.4e-42 143.0 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04082.1 - 1.8e-30 106.3 0.1 2.6e-30 105.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04082.1 - 6.9e-06 26.1 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCM04082.1 - 7.5e-05 22.2 0.0 0.00018 21.0 0.0 1.6 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CCM04082.1 - 8e-05 22.6 0.0 0.00035 20.5 0.0 2.0 3 0 0 3 3 3 1 NAD(P)H-binding Epimerase PF01370.21 CCM04082.1 - 0.00013 21.5 0.0 0.00035 20.1 0.0 1.7 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCM04082.1 - 0.015 14.4 0.0 0.035 13.2 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain rve_3 PF13683.6 CCM04082.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain DUF3328 PF11807.8 CCM04083.1 - 6.1e-15 55.6 0.8 7.9e-15 55.2 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Coq4 PF05019.13 CCM04084.1 - 9.3e-62 208.2 0.0 1.4e-30 106.3 0.0 2.1 2 0 0 2 2 2 2 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Chitin_synth_1 PF01644.17 CCM04085.1 - 1.6e-64 216.8 0.0 2.3e-64 216.3 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CCM04085.1 - 6.8e-26 90.0 0.1 1.9e-25 88.6 0.0 1.8 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CCM04085.1 - 1.2e-22 80.3 3.2 9e-15 54.3 0.1 2.6 3 0 0 3 3 3 2 Chitin synthase Importin_rep PF18773.1 CCM04086.1 - 2e-11 43.4 0.0 6.4e-11 41.8 0.0 1.9 1 0 0 1 1 1 1 Importin 13 repeat Xpo1 PF08389.12 CCM04086.1 - 2.8e-10 40.4 0.0 8.6e-09 35.6 0.0 3.3 4 0 0 4 4 4 1 Exportin 1-like protein Importin_rep_3 PF18806.1 CCM04086.1 - 0.00014 21.9 0.1 0.00091 19.2 0.1 2.5 2 0 0 2 2 2 1 Importin 13 repeat IBN_N PF03810.19 CCM04086.1 - 0.013 15.4 0.0 0.77 9.7 0.0 2.7 2 0 0 2 2 2 0 Importin-beta N-terminal domain CRM1_C PF08767.11 CCM04086.1 - 0.014 14.6 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 CRM1 C terminal Phage_holin_2_4 PF16082.5 CCM04087.1 - 0.044 13.5 0.1 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like DUF3681 PF12442.8 CCM04087.1 - 0.069 13.6 0.2 0.13 12.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) MFS_1 PF07690.16 CCM04088.1 - 0.42 9.5 10.1 5.1 5.9 10.1 2.1 1 1 0 1 1 1 0 Major Facilitator Superfamily ATP-synt_I PF03899.15 CCM04088.1 - 1.4 9.3 10.2 3.8 7.9 0.9 3.2 3 0 0 3 3 3 0 ATP synthase I chain UBN_AB PF14075.6 CCM04089.1 - 6.5e-40 137.1 0.2 3.1e-39 134.9 0.0 2.0 2 0 0 2 2 2 1 Ubinuclein conserved middle domain HUN PF08729.10 CCM04089.1 - 4.9e-14 52.1 0.5 1.2e-13 50.8 0.5 1.7 1 0 0 1 1 1 1 HPC2 and ubinuclein domain DNA_pol_lambd_f PF10391.9 CCM04091.1 - 1.5e-21 75.9 0.3 1.2e-19 69.9 0.1 2.5 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 CCM04091.1 - 1.4e-17 63.8 0.1 8.4e-17 61.3 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.6 CCM04091.1 - 2.5e-16 59.9 0.0 3.3e-15 56.3 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase beta palm HHH_5 PF14520.6 CCM04091.1 - 0.0009 19.8 0.0 1.3 9.7 0.1 2.7 1 1 1 2 2 2 2 Helix-hairpin-helix domain LIG3_BRCT PF16759.5 CCM04091.1 - 0.047 14.0 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain NTP_transf_2 PF01909.23 CCM04091.1 - 0.078 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain BRCT_2 PF16589.5 CCM04091.1 - 0.078 13.4 0.1 0.26 11.7 0.0 1.9 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain HHH PF00633.23 CCM04091.1 - 0.1 12.5 0.0 0.34 10.9 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif BRCT PF00533.26 CCM04091.1 - 0.15 12.5 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Methyltransf_25 PF13649.6 CCM04092.1 - 9.5e-09 35.9 0.0 3e-08 34.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM04092.1 - 2.2e-08 34.1 0.0 3.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM04092.1 - 2.3e-08 34.0 0.0 8.2e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04092.1 - 5.8e-08 33.3 0.0 1.2e-07 32.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM04092.1 - 0.00013 21.4 0.0 0.00089 18.6 0.0 2.1 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CCM04092.1 - 0.00058 20.6 0.0 0.0025 18.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CCM04092.1 - 0.00083 18.9 0.0 0.004 16.6 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.19 CCM04092.1 - 0.0027 17.8 0.0 0.019 15.1 0.0 2.1 1 1 1 2 2 2 1 FtsJ-like methyltransferase Methyltransf_29 PF03141.16 CCM04092.1 - 0.011 14.3 0.0 0.017 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.15 CCM04092.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase Peptidase_M16 PF00675.20 CCM04093.1 - 7.9e-17 61.6 0.0 1.3e-16 60.9 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) MOFRL PF05161.13 CCM04093.1 - 0.0034 17.5 1.1 0.0083 16.3 1.1 1.7 1 0 0 1 1 1 1 MOFRL family PLA2_B PF01735.18 CCM04094.1 - 1.6e-88 297.3 0.0 2.2e-88 296.8 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain DUF4470 PF14737.6 CCM04095.1 - 5.1e-24 84.3 0.0 1e-23 83.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 CCM04095.1 - 2.8e-10 40.1 13.6 6e-10 39.0 13.6 1.6 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 CCM04095.1 - 2.5 8.5 12.8 6 7.3 12.8 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding FMO-like PF00743.19 CCM04096.1 - 7.1e-24 84.1 0.0 1.1e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCM04096.1 - 3e-21 76.0 0.0 5.3e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM04096.1 - 7.7e-15 54.9 0.0 6.8e-07 28.8 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM04096.1 - 3.4e-11 42.9 0.1 1e-08 34.7 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.20 CCM04096.1 - 9.3e-05 22.5 0.0 0.0035 17.4 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 CCM04096.1 - 0.00012 22.6 0.0 0.12 13.0 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCM04096.1 - 0.0012 18.9 0.1 0.35 10.9 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CCM04096.1 - 0.0029 17.2 0.0 0.027 14.0 0.0 2.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase TrkA_N PF02254.18 CCM04096.1 - 0.0064 16.7 0.0 0.1 12.9 0.0 2.2 2 0 0 2 2 2 1 TrkA-N domain 2-Hacid_dh_C PF02826.19 CCM04096.1 - 0.036 13.4 1.3 0.48 9.8 0.0 2.6 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CCM04096.1 - 0.075 13.5 0.0 8.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CCM04096.1 - 0.12 11.7 0.0 0.31 10.3 0.0 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 CCM04096.1 - 0.14 10.8 0.0 0.39 9.3 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 CCM04096.1 - 0.15 11.1 0.0 2.3 7.2 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CCM04096.1 - 0.17 11.1 0.0 0.5 9.6 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain 3HCDH_N PF02737.18 CCM04096.1 - 0.23 11.3 0.0 11 5.8 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Velvet PF11754.8 CCM04097.1 - 5.2e-46 157.6 0.2 5.5e-38 131.3 0.0 4.7 2 2 1 3 3 3 2 Velvet factor Pyr_redox_2 PF07992.14 CCM04098.1 - 2.2e-11 43.6 0.0 1.1e-08 34.6 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM04098.1 - 2.8e-10 39.9 0.0 0.0042 16.4 0.0 3.3 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM04098.1 - 3.3e-10 40.0 2.1 6.6e-07 29.5 0.1 3.6 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CCM04098.1 - 1e-07 31.5 0.0 2e-06 27.2 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 CCM04098.1 - 1.7e-07 30.1 0.0 2.8e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox PF00070.27 CCM04098.1 - 2e-05 25.1 0.3 0.029 14.9 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM04098.1 - 3.8e-05 23.5 1.1 0.0019 17.9 0.4 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CCM04098.1 - 4.5e-05 22.8 0.1 0.001 18.4 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 CCM04098.1 - 5.2e-05 23.3 0.0 0.093 12.8 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 CCM04098.1 - 8.3e-05 21.9 0.2 0.0016 17.7 0.0 2.1 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 CCM04098.1 - 0.00015 21.7 0.7 0.75 9.8 0.0 3.0 4 0 0 4 4 4 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CCM04098.1 - 0.0011 18.2 0.2 0.0011 18.2 0.2 1.7 2 0 0 2 2 2 1 FAD binding domain ApbA PF02558.16 CCM04098.1 - 0.0031 17.2 0.9 0.068 12.8 0.1 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Amino_oxidase PF01593.24 CCM04098.1 - 0.0036 16.6 0.0 1.9 7.7 0.0 3.2 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase NAD_binding_7 PF13241.6 CCM04098.1 - 0.0037 17.7 0.0 2.6 8.5 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.12 CCM04098.1 - 0.013 14.5 0.1 0.24 10.4 0.1 2.5 3 0 0 3 3 3 0 Lycopene cyclase protein HI0933_like PF03486.14 CCM04098.1 - 0.014 14.1 1.8 0.022 13.5 0.1 2.1 3 0 0 3 3 3 0 HI0933-like protein Trp_halogenase PF04820.14 CCM04098.1 - 0.02 13.8 2.4 1.6 7.5 0.1 3.0 3 0 0 3 3 3 0 Tryptophan halogenase ThiF PF00899.21 CCM04098.1 - 0.055 12.8 0.0 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 ThiF family Glu_dehyd_C PF16912.5 CCM04098.1 - 0.083 12.4 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus GIDA PF01134.22 CCM04098.1 - 0.11 11.6 0.7 6.5 5.7 0.2 2.8 3 0 0 3 3 3 0 Glucose inhibited division protein A TrkA_N PF02254.18 CCM04098.1 - 0.12 12.6 0.5 3.2 8.0 0.1 2.4 2 0 0 2 2 2 0 TrkA-N domain Peptidase_M17_N PF02789.17 CCM04098.1 - 0.15 12.0 0.0 13 5.7 0.0 2.3 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain FAD_oxidored PF12831.7 CCM04098.1 - 0.34 10.2 1.3 0.59 9.4 0.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase ACOX PF01756.19 CCM04099.1 - 7.3e-27 94.1 0.0 1.4e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 CCM04099.1 - 3.2e-12 47.1 0.0 5.6e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 CCM04099.1 - 6.9e-07 29.4 0.0 1.6e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CCM04099.1 - 7.7e-07 29.4 0.5 1.7e-06 28.3 0.5 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain CHZ PF09649.10 CCM04100.1 - 8.3e-12 44.4 0.7 4.9e-11 41.9 0.7 2.4 1 0 0 1 1 1 1 Histone chaperone domain CHZ BUD22 PF09073.10 CCM04100.1 - 0.0058 16.0 18.0 0.0058 16.0 18.0 2.0 1 1 1 2 2 2 1 BUD22 DUF4611 PF15387.6 CCM04100.1 - 4.8 7.5 28.1 0.53 10.5 1.9 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) La PF05383.17 CCM04101.1 - 1.1e-14 54.2 0.0 2e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 CCM04101.1 - 7.5e-06 25.7 0.1 1.8e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCM04101.1 - 0.00039 20.4 0.0 0.00091 19.2 0.0 1.7 1 0 0 1 1 1 1 RNA binding motif AMP-binding PF00501.28 CCM04102.1 - 7.7e-94 314.7 0.0 1e-93 314.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM04102.1 - 0.012 16.5 0.1 0.043 14.8 0.0 2.0 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain PLDc_N PF13396.6 CCM04104.1 - 0.0094 15.9 0.3 0.0094 15.9 0.3 3.4 2 1 1 3 3 3 1 Phospholipase_D-nuclease N-terminal Pkinase_Tyr PF07714.17 CCM04105.1 - 2e-36 125.6 0.0 6.5e-36 123.9 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM04105.1 - 3.1e-31 108.7 0.0 8e-31 107.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CCM04105.1 - 0.2 11.0 0.0 0.74 9.1 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Abhydrolase_1 PF00561.20 CCM04106.1 - 4.1e-21 75.8 0.0 5.3e-19 68.9 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM04106.1 - 8.8e-11 41.5 0.0 1.4e-09 37.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM04106.1 - 4.2e-10 40.6 0.0 5.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CCM04106.1 - 0.0024 18.0 0.0 0.0038 17.4 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain AA_permease_2 PF13520.6 CCM04107.1 - 1.9e-58 198.3 39.1 2.5e-58 197.9 39.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCM04107.1 - 1.4e-14 53.5 30.6 2.5e-14 52.8 30.6 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CCM04108.1 - 6.7e-50 170.2 35.2 1.1e-49 169.5 35.2 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCM04108.1 - 7.9e-06 24.7 36.0 0.0015 17.2 21.1 2.3 2 1 0 2 2 2 2 Amino acid permease GST_C_2 PF13410.6 CCM04109.1 - 3.1e-05 23.9 0.1 5.3e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CCM04109.1 - 0.00051 20.4 0.1 0.00095 19.5 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM04109.1 - 0.0064 16.8 0.1 0.013 15.8 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GPI-anchored PF10342.9 CCM04110.1 - 8.5e-10 39.3 5.1 8.5e-10 39.3 5.1 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Herpes_capsid PF06112.11 CCM04110.1 - 3.6 7.6 15.6 5.4 7.1 15.6 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein G-alpha PF00503.20 CCM04111.1 - 3e-111 372.0 0.0 3.5e-111 371.8 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCM04111.1 - 1.6e-10 40.7 0.7 2.5e-06 27.1 0.0 3.0 3 0 0 3 3 3 2 ADP-ribosylation factor family TniB PF05621.11 CCM04111.1 - 0.00084 18.8 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein Gtr1_RagA PF04670.12 CCM04111.1 - 0.0022 17.4 0.0 1.3 8.3 0.0 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CCM04111.1 - 0.0083 16.3 0.0 1.4 9.1 0.0 2.8 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCM04111.1 - 0.026 14.3 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CCM04111.1 - 0.03 13.6 0.0 0.071 12.4 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin GTP_EFTU PF00009.27 CCM04111.1 - 0.079 12.5 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 CCM04111.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Glyco_hydro_16 PF00722.21 CCM04112.1 - 0.00027 20.5 0.0 0.00027 20.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Inp1 PF12634.7 CCM04112.1 - 0.24 11.4 2.0 0.48 10.4 2.0 1.4 1 0 0 1 1 1 0 Inheritance of peroxisomes protein 1 RAP1 PF07218.11 CCM04112.1 - 1.5 7.1 10.2 2.4 6.3 10.2 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) EBP50_C PF09007.11 CCM04112.1 - 2.2 9.3 6.9 10 7.1 5.1 2.2 2 0 0 2 2 2 0 EBP50, C-terminal Na_H_Exchanger PF00999.21 CCM04113.1 - 3e-72 243.5 35.7 3.7e-72 243.2 35.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Tim17 PF02466.19 CCM04113.1 - 0.031 14.7 1.6 2 8.9 0.0 2.9 3 1 0 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family DUF202 PF02656.15 CCM04114.1 - 0.0089 16.4 1.1 0.026 15.0 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF3311 PF11755.8 CCM04114.1 - 0.11 12.4 0.3 9.9 6.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) K_oxygenase PF13434.6 CCM04115.1 - 1e-07 31.5 0.0 5.6e-06 25.7 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CCM04115.1 - 1.8e-06 27.5 0.0 0.00063 19.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM04115.1 - 0.00033 20.0 0.0 0.065 12.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCM04115.1 - 0.00073 19.6 0.5 0.1 12.6 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CCM04115.1 - 0.031 13.9 0.0 3.8 7.0 0.0 2.4 2 1 0 2 2 2 0 FAD dependent oxidoreductase DUF202 PF02656.15 CCM04116.1 - 0.59 10.6 7.3 5.2 7.6 7.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF202) 60KD_IMP PF02096.20 CCM04117.1 - 8.2e-19 68.1 7.6 1.1e-18 67.7 7.6 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein BING4CT PF08149.11 CCM04118.1 - 1.6e-25 88.7 0.0 8e-25 86.5 0.0 1.9 2 0 0 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.32 CCM04118.1 - 5.1e-06 27.1 0.9 3.8e-05 24.4 0.1 2.6 3 0 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 CCM04118.1 - 0.23 10.1 0.0 0.32 9.6 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 OPT PF03169.15 CCM04119.1 - 2.1e-115 386.8 36.9 2.3e-115 386.6 36.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3792 PF12670.7 CCM04119.1 - 5.2 7.3 15.4 1.3 9.3 9.9 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) Spc7 PF08317.11 CCM04120.1 - 0.00064 18.7 4.8 0.00064 18.7 4.8 8.8 2 2 8 10 10 10 6 Spc7 kinetochore protein EzrA PF06160.12 CCM04120.1 - 0.0016 16.7 6.3 0.0016 16.7 6.3 6.5 3 3 3 6 6 6 3 Septation ring formation regulator, EzrA WD40_alt PF14077.6 CCM04120.1 - 0.84 9.5 6.8 7 6.6 0.1 5.2 5 0 0 5 5 5 0 Alternative WD40 repeat motif Fez1 PF06818.15 CCM04120.1 - 6.4 7.2 128.7 0.094 13.2 11.6 7.8 2 2 5 7 7 7 0 Fez1 OGFr_N PF04664.13 CCM04122.1 - 5.3e-43 147.0 0.1 8.6e-43 146.3 0.1 1.3 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region S1FA PF04689.13 CCM04122.1 - 9.5 6.5 7.3 4.8 7.4 0.2 3.3 2 1 1 3 3 3 0 DNA binding protein S1FA DUF727 PF05303.12 CCM04123.1 - 6.6e-09 35.8 0.1 8.2e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Sec1 PF00995.23 CCM04124.1 - 3.8e-123 412.7 0.0 4.5e-123 412.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family SWC7 PF17330.2 CCM04124.1 - 0.16 12.1 0.0 0.51 10.4 0.0 1.9 1 0 0 1 1 1 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 Fez1 PF06818.15 CCM04125.1 - 0.00036 21.1 51.5 0.0043 17.5 3.2 3.3 1 1 1 3 3 3 3 Fez1 HAUS-augmin3 PF14932.6 CCM04125.1 - 0.0049 16.5 13.8 0.0049 16.5 13.8 4.1 1 1 3 4 4 4 1 HAUS augmin-like complex subunit 3 HAP1_N PF04849.13 CCM04125.1 - 0.0093 15.2 9.8 0.0093 15.2 9.8 4.0 1 1 3 4 4 4 2 HAP1 N-terminal conserved region Filament PF00038.21 CCM04125.1 - 0.013 15.1 13.2 0.013 15.1 13.2 4.6 1 1 4 5 5 5 0 Intermediate filament protein DUF4686 PF15742.5 CCM04125.1 - 0.25 10.5 52.1 2 7.5 10.4 3.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4686) Spc7 PF08317.11 CCM04125.1 - 1.6 7.5 62.3 0.011 14.6 16.9 3.8 1 1 2 3 3 3 0 Spc7 kinetochore protein APG6_N PF17675.1 CCM04125.1 - 2.3 8.7 73.7 2.1 8.9 7.3 4.9 1 1 4 5 5 4 0 Apg6 coiled-coil region E2R135 PF11570.8 CCM04125.1 - 3.8 7.8 28.8 1.2 9.5 1.0 4.4 2 1 2 4 4 4 0 Coiled-coil receptor-binding R-domain of colicin E2 MscS_porin PF12795.7 CCM04125.1 - 6.1 6.3 71.5 18 4.8 34.7 3.4 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Tropomyosin_1 PF12718.7 CCM04125.1 - 7.9 6.6 65.4 0.37 10.9 8.6 4.1 1 1 3 4 4 4 0 Tropomyosin like FlaC_arch PF05377.11 CCM04125.1 - 9.1 6.8 15.5 6.6 7.2 0.7 5.5 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) COPIIcoated_ERV PF07970.12 CCM04126.1 - 5.9e-83 278.1 2.0 9.9e-83 277.3 2.0 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CCM04126.1 - 3.5e-26 91.4 1.8 3.7e-26 91.3 0.1 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) LtuB PF17455.2 CCM04126.1 - 0.038 14.6 1.9 0.081 13.6 1.9 1.6 1 0 0 1 1 1 0 Late transcription unit B Nitroreductase PF00881.24 CCM04128.1 - 1.3e-16 61.2 0.0 1.4e-16 61.0 0.0 1.0 1 0 0 1 1 1 1 Nitroreductase family Filament PF00038.21 CCM04129.1 - 0.0017 18.0 26.3 0.0023 17.5 10.1 2.1 1 1 1 2 2 2 2 Intermediate filament protein Cob_adeno_trans PF01923.18 CCM04129.1 - 0.015 15.4 4.0 0.015 15.4 4.0 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase AAA_13 PF13166.6 CCM04129.1 - 2.2 6.8 19.7 0.46 9.1 16.1 1.6 1 1 0 1 1 1 0 AAA domain PspB PF06667.12 CCM04130.1 - 0.89 9.7 5.3 8.5 6.5 1.5 2.6 2 0 0 2 2 2 0 Phage shock protein B DUF2937 PF11157.8 CCM04130.1 - 2.7 7.7 5.6 5.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) p450 PF00067.22 CCM04133.1 - 1.7e-22 79.9 0.0 1.9e-22 79.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Noc2 PF03715.13 CCM04134.1 - 5.1e-57 193.4 2.3 4.6e-56 190.3 0.5 2.9 3 0 0 3 3 3 1 Noc2p family rve PF00665.26 CCM04134.1 - 0.022 15.0 0.7 0.29 11.3 0.0 2.9 4 0 0 4 4 4 0 Integrase core domain TFIIA PF03153.13 CCM04134.1 - 0.95 9.4 13.7 2.3 8.1 13.7 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_C37 PF05416.12 CCM04134.1 - 1.6 7.1 6.3 3.2 6.2 6.3 1.4 1 0 0 1 1 1 0 Southampton virus-type processing peptidase BUD22 PF09073.10 CCM04134.1 - 7.4 5.8 21.1 12 5.1 21.1 1.3 1 0 0 1 1 1 0 BUD22 SNF2_N PF00176.23 CCM04135.1 - 6.5e-37 127.0 0.0 3e-36 124.9 0.0 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM04135.1 - 1.6e-10 41.3 0.0 1.2e-08 35.3 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain VIGSSK PF14773.6 CCM04135.1 - 2.6e-06 27.5 0.0 1.1e-05 25.5 0.0 2.0 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal ResIII PF04851.15 CCM04135.1 - 0.024 14.6 0.0 0.081 12.9 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CCM04135.1 - 0.087 12.0 0.0 0.18 11.0 0.0 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase tRNA-synt_1 PF00133.22 CCM04136.1 - 7.9e-39 133.4 0.0 2.4e-29 102.1 0.0 3.1 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CCM04136.1 - 1.1e-15 58.0 0.0 2.5e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CCM04136.1 - 8.2e-14 51.2 0.0 1.6e-07 30.4 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CCM04136.1 - 7.8e-08 32.0 0.0 1.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain HMG_box PF00505.19 CCM04137.1 - 1.9e-24 85.9 1.6 1.9e-24 85.9 1.6 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM04137.1 - 1.2e-18 67.4 2.0 1.2e-18 67.4 2.0 1.6 2 0 0 2 2 2 1 HMG-box domain CHDNT PF08073.12 CCM04137.1 - 0.0003 20.7 0.0 0.00089 19.2 0.0 1.7 1 1 0 2 2 2 1 CHDNT (NUC034) domain YABBY PF04690.13 CCM04137.1 - 0.0018 18.9 1.6 0.0018 18.9 1.6 1.4 1 1 0 1 1 1 1 YABBY protein HMG_box_5 PF14887.6 CCM04137.1 - 0.05 13.6 5.1 0.026 14.5 2.9 1.7 1 1 0 1 1 1 0 HMG (high mobility group) box 5 Oxysterol_BP PF01237.18 CCM04138.1 - 1.8e-60 204.8 1.7 2.6e-52 177.9 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein Peptidase_C65 PF10275.9 CCM04139.1 - 3.3e-68 229.8 0.0 3.8e-68 229.6 0.0 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 CCM04139.1 - 0.00015 22.3 0.0 0.015 15.8 0.0 2.2 2 0 0 2 2 2 2 OTU-like cysteine protease Aminotran_4 PF01063.19 CCM04140.1 - 5e-22 78.9 0.0 6.1e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV PseudoU_synth_1 PF01416.20 CCM04141.1 - 1.6e-24 86.4 0.0 5.1e-23 81.6 0.0 3.0 2 1 0 2 2 2 1 tRNA pseudouridine synthase BAALC_N PF06989.12 CCM04141.1 - 0.019 15.3 0.1 0.019 15.3 0.1 2.5 4 0 0 4 4 4 0 BAALC N-terminus SurE PF01975.17 CCM04142.1 - 1.4e-37 129.4 0.2 1.9e-37 128.9 0.2 1.2 1 0 0 1 1 1 1 Survival protein SurE Cerato-platanin PF07249.12 CCM04143.1 - 1.1e-27 96.5 3.4 1.5e-27 96.1 3.4 1.1 1 0 0 1 1 1 1 Cerato-platanin SurE PF01975.17 CCM04144.1 - 4.3e-32 111.5 0.1 6e-32 111.0 0.1 1.2 1 0 0 1 1 1 1 Survival protein SurE p450 PF00067.22 CCM04145.1 - 3.2e-63 214.1 0.0 4.8e-63 213.5 0.0 1.2 1 1 0 1 1 1 1 Cytochrome P450 HSP20 PF00011.21 CCM04146.1 - 5.5e-23 81.0 0.1 7.5e-23 80.6 0.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CCM04146.1 - 7.1e-11 41.5 0.0 1.1e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA BON PF04972.17 CCM04146.1 - 0.0068 16.7 0.2 0.45 10.9 0.1 2.2 2 0 0 2 2 2 1 BON domain FKBP26_C PF18046.1 CCM04146.1 - 0.072 13.2 0.1 6.7 6.9 0.0 2.2 2 0 0 2 2 2 0 FKBP26_C-terminal p450 PF00067.22 CCM04147.1 - 6.5e-77 259.2 0.0 1.1e-76 258.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM04148.1 - 3.3e-36 125.0 0.0 3.8e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TPR_2 PF07719.17 CCM04149.1 - 1.8e-11 43.2 24.5 0.003 17.5 0.8 9.8 12 0 0 12 12 10 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCM04149.1 - 6e-11 41.7 12.0 0.039 14.2 0.0 10.1 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM04149.1 - 9.5e-11 42.2 16.8 0.013 16.2 0.0 6.6 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCM04149.1 - 1.3e-10 41.6 22.0 0.0018 18.7 0.2 7.9 8 2 2 10 10 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 CCM04149.1 - 7.8e-10 38.5 2.9 0.023 15.0 0.0 6.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCM04149.1 - 3.7e-09 36.6 25.2 2.4 9.2 0.0 9.8 8 2 2 10 10 10 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCM04149.1 - 5.7e-09 35.5 12.2 0.00017 21.2 0.2 6.2 7 0 0 7 7 7 2 TPR repeat TPR_12 PF13424.6 CCM04149.1 - 1.4e-08 34.9 25.3 0.00042 20.6 0.3 9.1 8 2 2 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 CCM04149.1 - 3.3e-08 33.0 14.7 0.23 11.3 0.1 8.2 10 0 0 10 10 10 3 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 CCM04149.1 - 8.8e-06 26.2 1.4 0.029 14.8 0.1 3.6 3 0 0 3 3 3 2 Alkyl sulfatase dimerisation TPR_7 PF13176.6 CCM04149.1 - 2.1e-05 24.2 21.0 0.38 10.9 0.4 8.0 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCM04149.1 - 0.00071 20.0 8.0 13 6.7 0.2 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_20 PF14561.6 CCM04149.1 - 0.0015 18.8 6.6 2.1 8.7 0.2 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM04149.1 - 0.0098 16.1 10.7 50 4.2 0.2 6.3 5 2 2 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 UPF0253 PF06786.12 CCM04149.1 - 0.026 14.8 0.1 0.53 10.6 0.0 2.7 3 0 0 3 3 2 0 Uncharacterised protein family (UPF0253) NARP1 PF12569.8 CCM04149.1 - 0.053 12.4 0.3 1.5 7.7 0.0 2.9 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 CCM04149.1 - 0.081 13.1 13.7 0.081 13.1 0.4 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CCM04149.1 - 0.18 11.2 10.1 2.4 7.5 0.1 4.7 5 1 0 5 5 5 0 MalT-like TPR region HrpB1_HrpK PF09613.10 CCM04149.1 - 0.21 11.2 2.5 3.2 7.4 0.1 3.3 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 CCM04149.1 - 0.3 11.0 13.9 14 5.7 0.5 6.9 8 0 0 8 8 8 0 Tetratricopeptide repeat p450 PF00067.22 CCM04150.1 - 9.5e-77 258.7 0.0 1.6e-76 258.0 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 SICA_C PF12879.7 CCM04150.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 SICA C-terminal inner membrane domain ThrE PF06738.12 CCM04151.1 - 8.5e-40 136.6 28.4 3.6e-38 131.3 9.5 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 CCM04151.1 - 1.1e-09 38.5 10.0 1.1e-09 38.5 10.0 2.5 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE Gti1_Pac2 PF09729.9 CCM04152.1 - 1.8e-30 106.4 9.1 4.7e-27 95.3 0.5 3.1 2 1 1 3 3 3 2 Gti1/Pac2 family MGC-24 PF05283.11 CCM04152.1 - 8.8 6.8 8.6 22 5.5 8.6 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MutL_C PF08676.11 CCM04153.1 - 4.7e-18 65.4 0.1 2.4e-17 63.1 0.0 2.1 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CCM04153.1 - 4.5e-16 58.6 0.0 8.1e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CCM04153.1 - 7.8e-12 45.2 0.0 1.6e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCM04153.1 - 5.1e-07 30.2 0.0 1.1e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-MYND PF01753.18 CCM04154.1 - 1.9e-10 40.6 15.9 3.6e-10 39.7 15.9 1.5 1 0 0 1 1 1 1 MYND finger Ank_2 PF12796.7 CCM04154.1 - 5.4e-06 26.9 0.0 1e-05 26.0 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCM04154.1 - 0.007 16.9 0.0 8.1 7.2 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CCM04154.1 - 0.0079 16.6 0.2 0.85 10.2 0.3 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 CCM04154.1 - 0.029 14.7 0.3 0.37 11.2 0.1 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM04154.1 - 0.2 12.3 0.6 51 4.9 0.1 3.0 2 0 0 2 2 2 0 Ankyrin repeat DZR PF12773.7 CCM04154.1 - 0.82 9.7 7.0 2.3 8.3 7.0 1.8 1 1 0 1 1 1 0 Double zinc ribbon PolC_DP2 PF03833.13 CCM04154.1 - 1.2 6.9 3.5 1.6 6.5 3.5 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Methyltransf_22 PF13383.6 CCM04155.1 - 4.8e-20 72.2 0.0 6.1e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 CCM04155.1 - 7.5e-08 32.6 0.0 1.2e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Pkinase_Tyr PF07714.17 CCM04156.1 - 2.7e-51 174.3 0.0 5.4e-51 173.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM04156.1 - 2.4e-38 132.0 0.0 3.7e-38 131.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 CCM04156.1 - 0.0011 18.4 0.0 0.0024 17.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM04156.1 - 0.0067 16.4 1.0 0.014 15.3 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family TLD PF07534.16 CCM04159.1 - 8.8e-28 97.3 0.0 2.2e-27 96.0 0.0 1.7 1 0 0 1 1 1 1 TLD DUF3433 PF11915.8 CCM04159.1 - 8.1e-19 67.9 6.3 3.6e-12 46.6 0.5 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) Zip PF02535.22 CCM04164.1 - 1.6e-44 152.5 6.2 1.7e-44 152.4 6.2 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Zip PF02535.22 CCM04165.1 - 1.2e-57 195.6 11.6 2.9e-57 194.4 11.6 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter UNC-50 PF05216.13 CCM04165.1 - 8.7 5.8 8.9 0.098 12.2 0.7 1.9 3 0 0 3 3 3 0 UNC-50 family Glyco_hydro_47 PF01532.20 CCM04166.1 - 3.9e-131 438.1 0.0 4.5e-131 437.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF2781 PF10914.8 CCM04167.1 - 2.2e-39 135.2 11.0 2.6e-39 135.0 11.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) WD40 PF00400.32 CCM04168.1 - 1.5e-08 35.1 1.2 1.1 10.2 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat CPSF_A PF03178.15 CCM04168.1 - 0.0017 17.7 0.0 0.052 12.9 0.0 2.7 1 1 1 2 2 2 1 CPSF A subunit region Nup160 PF11715.8 CCM04168.1 - 0.055 12.1 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Cys_Met_Meta_PP PF01053.20 CCM04169.1 - 9.5e-53 179.1 0.0 3.9e-50 170.5 0.0 2.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Glyco_hydro_47 PF01532.20 CCM04172.1 - 2.3e-138 461.9 0.0 2.7e-138 461.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Evr1_Alr PF04777.13 CCM04173.1 - 2.1e-28 98.7 0.1 4.2e-28 97.7 0.1 1.5 1 0 0 1 1 1 1 Erv1 / Alr family NmrA PF05368.13 CCM04174.1 - 1.5e-32 113.0 0.1 1.9e-32 112.7 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCM04174.1 - 4.6e-15 56.0 0.1 1.1e-14 54.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 CCM04174.1 - 0.00038 20.6 0.5 0.00078 19.6 0.5 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 CCM04174.1 - 0.0023 17.9 1.4 0.004 17.1 1.4 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 CCM04174.1 - 0.0078 16.3 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 CCM04174.1 - 0.049 14.1 0.4 0.084 13.3 0.4 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF956 PF06115.11 CCM04174.1 - 0.073 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF956) Epimerase PF01370.21 CCM04174.1 - 0.074 12.5 0.2 0.26 10.7 0.2 2.0 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04174.1 - 0.14 11.1 0.6 0.5 9.3 0.5 1.9 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family SH3_1 PF00018.28 CCM04175.1 - 5.7e-10 38.6 0.0 9.5e-10 37.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCM04175.1 - 1.9e-07 30.6 0.0 3.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCM04175.1 - 7.4e-07 28.9 0.0 1.2e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_4 PF06347.13 CCM04175.1 - 0.0086 15.9 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain adh_short PF00106.25 CCM04176.1 - 9.9e-43 145.9 0.6 1.3e-42 145.4 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04176.1 - 1.7e-35 122.7 0.4 2.1e-35 122.4 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04176.1 - 2e-13 50.6 0.6 2.9e-13 50.1 0.6 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCM04176.1 - 0.0069 15.6 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 CCM04176.1 - 0.023 14.0 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 CCM04176.1 - 0.024 14.0 0.1 0.072 12.4 0.1 1.9 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Sacchrp_dh_NADP PF03435.18 CCM04176.1 - 0.03 14.6 0.3 0.64 10.3 0.2 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 CCM04177.1 - 1.7e-44 151.6 0.7 2.1e-44 151.3 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04177.1 - 8.5e-36 123.7 0.6 1.1e-35 123.3 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04177.1 - 1.2e-11 44.8 0.5 1.7e-11 44.3 0.5 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCM04177.1 - 0.0036 16.5 0.0 0.0047 16.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein PA PF02225.22 CCM04177.1 - 0.014 15.4 1.0 0.034 14.1 1.0 1.7 1 0 0 1 1 1 0 PA domain THF_DHG_CYH_C PF02882.19 CCM04177.1 - 0.03 13.6 0.2 0.068 12.5 0.2 1.7 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.8 CCM04177.1 - 0.037 13.8 0.4 0.13 12.0 0.1 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF2244 PF10003.9 CCM04177.1 - 0.05 13.3 0.0 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) NmrA PF05368.13 CCM04178.1 - 4.7e-32 111.4 0.0 6.6e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CCM04178.1 - 2e-16 60.4 0.4 3.4e-16 59.7 0.4 1.4 1 1 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 CCM04178.1 - 0.00021 21.4 0.1 0.00037 20.6 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 CCM04178.1 - 0.00046 20.2 0.1 0.00075 19.4 0.1 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 CCM04178.1 - 0.0049 16.9 0.0 0.0095 16.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 CCM04178.1 - 0.033 14.4 0.2 0.078 13.2 0.2 1.7 1 0 0 1 1 1 0 TrkA-N domain ADH_zinc_N PF00107.26 CCM04178.1 - 0.035 14.1 0.5 0.13 12.2 0.2 2.1 2 1 1 3 3 3 0 Zinc-binding dehydrogenase DXP_reductoisom PF02670.16 CCM04178.1 - 0.054 14.2 0.1 0.13 13.0 0.1 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Epimerase PF01370.21 CCM04178.1 - 0.095 12.1 0.0 0.31 10.5 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCM04178.1 - 0.16 12.5 0.1 0.31 11.5 0.1 1.5 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CCM04178.1 - 0.16 12.5 3.3 3.1 8.4 0.3 2.4 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Paf1 PF03985.13 CCM04179.1 - 1.4e-69 235.1 0.4 1.8e-69 234.8 0.4 1.1 1 0 0 1 1 1 1 Paf1 CRAL_TRIO PF00650.20 CCM04180.1 - 7.8e-28 97.2 0.0 1.4e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CCM04180.1 - 1.7e-05 24.9 0.1 3.9e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Histone PF00125.24 CCM04181.1 - 3.8e-50 169.6 3.9 4.2e-50 169.5 3.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CCM04181.1 - 1.9e-05 24.7 0.1 3.7e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CCM04181.1 - 4.3e-05 23.8 0.0 7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 CCM04181.1 - 0.00019 22.0 1.6 0.00024 21.7 1.6 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 CCM04181.1 - 0.0055 17.0 0.1 0.0055 17.0 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 CCM04182.1 - 4.4e-07 30.0 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 CCM04182.1 - 6.4e-05 23.1 0.1 9.1e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 CCM04182.1 - 0.00014 22.2 0.0 0.00018 21.8 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CCM04182.1 - 0.00098 19.4 0.1 0.0018 18.5 0.1 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM04182.1 - 0.0019 18.5 0.2 0.0022 18.4 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CCM04182.1 - 0.061 13.4 0.0 0.07 13.2 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit F-box-like PF12937.7 CCM04183.1 - 0.0005 19.9 0.0 0.0013 18.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like RhoGAP PF00620.27 CCM04184.1 - 2.9e-44 150.6 0.0 5.6e-44 149.6 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 CCM04184.1 - 3.2e-16 59.4 0.2 9e-16 57.9 0.2 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Baculo_PEP_C PF04513.12 CCM04184.1 - 0.17 11.9 0.6 14 5.8 0.0 2.6 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 CCM04184.1 - 2.1 7.6 3.9 3.4 6.9 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Occludin_ELL PF07303.13 CCM04184.1 - 4.7 8.0 8.0 0.67 10.7 2.1 2.7 3 0 0 3 3 3 0 Occludin homology domain Methyltransf_16 PF10294.9 CCM04185.1 - 4.5e-26 91.6 0.0 6e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CCM04185.1 - 0.073 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Rhomboid PF01694.22 CCM04186.1 - 2.8e-18 66.3 17.9 1.9e-17 63.6 17.9 2.3 1 1 0 1 1 1 1 Rhomboid family Cas1_AcylT PF07779.12 CCM04188.1 - 3.6e-147 491.1 11.6 4.5e-147 490.8 11.6 1.1 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p Vta1 PF04652.16 CCM04188.1 - 4.2e-43 146.8 0.2 3.7e-42 143.7 0.2 2.1 1 1 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 CCM04188.1 - 1.1e-16 60.2 0.0 2.3e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Vta1 C-terminal domain PC-Esterase PF13839.6 CCM04188.1 - 9.5e-06 25.6 0.0 1.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p ATPase_gene1 PF09527.10 CCM04188.1 - 0.052 13.7 3.9 0.1 12.7 0.2 3.2 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter adh_short_C2 PF13561.6 CCM04189.1 - 9.6e-52 175.9 0.0 1.1e-51 175.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM04189.1 - 1e-34 119.7 0.0 1.3e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM04189.1 - 6.1e-09 36.0 0.0 8.1e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCM04189.1 - 0.00067 19.1 0.0 0.00098 18.6 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.8 CCM04189.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Arrestin_C PF02752.22 CCM04190.1 - 1.8e-10 41.4 0.0 2.1e-09 38.0 0.0 2.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCM04190.1 - 0.015 15.3 0.0 2.5 8.2 0.1 2.6 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain FR47 PF08445.10 CCM04191.1 - 2.8e-07 30.4 0.0 5e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 CCM04191.1 - 5.9e-07 29.5 0.0 9.4e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM04191.1 - 4.7e-06 26.8 0.0 7.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCM04191.1 - 0.00053 20.3 0.0 0.00093 19.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CCM04191.1 - 0.015 16.0 0.0 0.031 15.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CCM04191.1 - 0.024 14.7 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RNase_P_pop3 PF08228.11 CCM04192.1 - 2.2e-14 53.8 0.0 6.9e-12 45.7 0.0 2.6 2 1 0 2 2 2 2 RNase P subunit Pop3 Ribosomal_L7Ae PF01248.26 CCM04192.1 - 0.21 11.3 0.1 0.68 9.7 0.0 1.8 2 1 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1262 PF06880.11 CCM04193.1 - 0.09 13.2 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1262) HEAT PF02985.22 CCM04193.1 - 0.093 13.0 4.2 0.73 10.3 0.0 4.4 6 0 0 6 6 6 0 HEAT repeat Chorismate_bind PF00425.18 CCM04194.1 - 1.3e-68 231.3 0.0 2.5e-68 230.5 0.0 1.4 1 1 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 CCM04194.1 - 2.9e-35 121.8 0.0 4.1e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 CCM04194.1 - 8.2e-13 48.8 0.0 2.6e-12 47.2 0.0 1.8 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 CCM04194.1 - 3.4e-05 23.7 0.9 0.00019 21.2 0.9 2.0 1 1 0 1 1 1 1 Peptidase C26 2OG-FeII_Oxy PF03171.20 CCM04195.1 - 4e-05 24.0 0.0 6.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCM04195.1 - 0.01 16.6 0.0 0.019 15.7 0.0 1.5 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal UQ_con PF00179.26 CCM04196.1 - 1.8e-40 137.9 0.1 2.2e-40 137.5 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CCM04196.1 - 0.0026 17.6 0.0 0.0036 17.1 0.0 1.3 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 CCM04196.1 - 0.059 13.1 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 CCM04196.1 - 0.088 13.1 0.2 0.12 12.6 0.1 1.4 1 1 0 1 1 1 0 RWD domain RRM_1 PF00076.22 CCM04197.1 - 2.1e-07 30.7 0.0 1.2e-06 28.3 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC45 PF02724.14 CCM04197.1 - 0.84 7.9 5.9 0.77 8.0 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Draxin PF15550.6 CCM04197.1 - 7.9 6.2 11.8 5 6.9 10.6 1.3 1 1 0 1 1 1 0 Draxin SNARE PF05739.19 CCM04198.1 - 2.5e-13 49.8 0.1 2.5e-13 49.8 0.1 2.5 4 0 0 4 4 4 1 SNARE domain Syntaxin-5_N PF11416.8 CCM04198.1 - 4.8e-06 25.7 0.5 4.8e-06 25.7 0.5 2.2 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin-18_N PF10496.9 CCM04198.1 - 2.3e-05 24.5 6.2 2.8e-05 24.3 0.1 3.2 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus Syntaxin PF00804.25 CCM04198.1 - 0.00013 21.7 0.7 0.00013 21.7 0.7 2.5 2 1 0 2 2 2 1 Syntaxin DUF1351 PF07083.11 CCM04198.1 - 0.012 15.4 2.0 0.012 15.4 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) zf-C4H2 PF10146.9 CCM04198.1 - 0.013 15.8 6.8 0.2 12.0 1.6 2.1 2 0 0 2 2 2 0 Zinc finger-containing protein DUF16 PF01519.16 CCM04198.1 - 0.02 15.3 0.2 0.02 15.3 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 End3 PF12761.7 CCM04198.1 - 0.17 12.1 0.3 0.17 12.1 0.3 2.7 2 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 BLOC1_2 PF10046.9 CCM04198.1 - 0.26 11.6 10.0 0.26 11.6 1.2 3.1 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 CCM04198.1 - 0.9 10.0 10.5 0.41 11.1 1.6 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 CCM04198.1 - 1.4 9.6 8.1 0.53 10.9 0.9 3.0 3 0 0 3 3 3 0 SlyX UPF0242 PF06785.11 CCM04198.1 - 2.8 8.0 13.8 4.6 7.3 0.2 3.0 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spectrin PF00435.21 CCM04198.1 - 7.3 7.1 9.0 0.84 10.2 0.4 2.9 3 1 0 3 3 3 0 Spectrin repeat DUF1664 PF07889.12 CCM04198.1 - 9.1 6.3 12.4 3.2 7.8 1.3 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) NAD_Gly3P_dh_C PF07479.14 CCM04199.1 - 4.2e-50 169.7 0.4 6.5e-50 169.1 0.4 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 CCM04199.1 - 2.8e-33 115.1 0.0 4.6e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CCM04199.1 - 1.9e-05 25.1 0.0 8.2e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 CCM04199.1 - 7.3e-05 22.4 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 CCM04199.1 - 0.0035 17.5 0.0 0.009 16.2 0.0 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 CCM04199.1 - 0.0061 16.8 0.0 0.51 10.6 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain Shikimate_DH PF01488.20 CCM04199.1 - 0.027 14.5 0.0 0.094 12.8 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CCM04199.1 - 0.088 13.1 0.0 0.72 10.1 0.0 2.2 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Ank_2 PF12796.7 CCM04200.1 - 1.3e-08 35.3 0.0 2.6e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) zf-CCCH_4 PF18044.1 CCM04200.1 - 2.5e-07 30.3 13.3 0.00097 18.9 3.1 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger Ank_5 PF13857.6 CCM04200.1 - 3.4e-06 27.2 0.0 1.7e-05 25.0 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCM04200.1 - 4.7e-06 27.0 0.0 1.2e-05 25.7 0.0 1.8 2 0 0 2 2 1 1 Ankyrin repeats (many copies) zf-CCCH_2 PF14608.6 CCM04200.1 - 3.7e-05 24.0 4.4 3.7e-05 24.0 4.4 2.6 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger Ank PF00023.30 CCM04200.1 - 4.9e-05 23.6 0.0 0.0031 17.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat zf_CCCH_4 PF18345.1 CCM04200.1 - 7.7e-05 22.6 15.4 0.0013 18.7 1.6 2.9 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 CCM04200.1 - 0.00017 21.4 10.2 0.035 14.0 1.8 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCM04200.1 - 0.00064 20.4 2.8 0.0013 19.5 0.2 2.3 2 0 0 2 2 2 1 Torus domain Ank_3 PF13606.6 CCM04200.1 - 0.00071 19.8 0.0 0.039 14.5 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat zf-CCCH_3 PF15663.5 CCM04200.1 - 0.52 10.5 2.7 4.8 7.5 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger containing family GARS_A PF01071.19 CCM04201.1 - 1.8e-78 262.8 0.0 2.6e-78 262.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 CCM04201.1 - 9.1e-34 116.1 0.0 2.2e-33 114.9 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 CCM04201.1 - 4.1e-33 114.7 0.0 8.7e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 CCM04201.1 - 5.8e-27 93.8 0.3 1.5e-26 92.5 0.3 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 CCM04201.1 - 1.6e-15 57.5 1.0 1.6e-14 54.3 0.8 2.6 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain CPSase_L_D2 PF02786.17 CCM04201.1 - 0.00011 21.8 0.0 0.00019 21.0 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.11 CCM04201.1 - 0.034 13.7 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Pal1 PF08316.11 CCM04202.1 - 0.85 10.4 0.0 0.85 10.4 0.0 3.2 3 1 0 3 3 3 0 Pal1 cell morphology protein ATP11 PF06644.11 CCM04202.1 - 1.6 8.4 9.1 6.8 6.4 9.1 2.1 1 1 0 1 1 1 0 ATP11 protein MRP-S25 PF13741.6 CCM04204.1 - 2.2e-53 181.2 2.9 4.5e-53 180.2 2.9 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 CCM04204.1 - 8.3e-05 22.9 3.3 0.0013 19.0 1.8 2.8 2 1 0 2 2 2 1 Mitochondrial ribosomal protein S23 PCI PF01399.27 CCM04205.1 - 1.2e-17 64.4 0.0 4.2e-17 62.6 0.0 2.0 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 CCM04205.1 - 9.7e-05 22.4 0.8 0.00022 21.3 0.8 1.6 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain TPR_20 PF14561.6 CCM04205.1 - 0.054 13.8 0.5 0.2 12.0 0.5 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Drc1-Sld2 PF11719.8 CCM04206.1 - 1.4e-13 51.2 0.6 1.4e-13 51.2 0.6 2.5 1 1 1 2 2 2 2 DNA replication and checkpoint protein THEG4 PF15834.5 CCM04206.1 - 0.31 11.0 2.8 0.7 9.9 2.8 1.6 1 0 0 1 1 1 0 Testis highly expressed protein 4 Pal1 PF08316.11 CCM04207.1 - 0.055 14.2 1.2 0.088 13.6 0.0 2.1 2 0 0 2 2 2 0 Pal1 cell morphology protein SF3A2 PF16835.5 CCM04208.1 - 4e-37 126.5 0.2 5.9e-37 125.9 0.2 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 CCM04208.1 - 2.2e-06 27.9 0.7 2.2e-06 27.9 0.7 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type PRP4 PF08799.11 CCM04208.1 - 0.0085 15.6 0.9 0.018 14.6 0.9 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like CactinC_cactus PF09732.9 CCM04208.1 - 0.032 14.2 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 Cactus-binding C-terminus of cactin protein S1 PF00575.23 CCM04209.1 - 3.1e-48 162.0 20.9 1.2e-11 44.8 0.0 10.5 10 0 0 10 10 10 7 S1 RNA binding domain TPR_16 PF13432.6 CCM04209.1 - 9.5e-08 32.6 0.0 0.00068 20.2 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM04209.1 - 2e-07 31.4 0.0 0.078 13.5 0.0 3.9 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCM04209.1 - 3.4e-06 27.4 0.1 0.056 14.3 0.0 5.0 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_21 PF09976.9 CCM04209.1 - 0.00023 20.9 0.1 0.0005 19.8 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain NRDE-2 PF08424.10 CCM04209.1 - 0.0003 20.0 4.6 0.066 12.3 1.3 3.4 1 1 1 2 2 2 1 NRDE-2, necessary for RNA interference TPR_12 PF13424.6 CCM04209.1 - 0.00031 21.0 1.5 1.5 9.2 0.2 3.3 2 1 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM04209.1 - 0.00032 20.8 0.1 0.0011 19.2 0.0 2.0 2 0 0 2 2 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CCM04209.1 - 0.00051 19.3 1.6 0.068 12.4 0.1 2.8 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM04209.1 - 0.0015 18.5 0.8 6.5 7.1 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat Glyco_hydro_65C PF03633.15 CCM04209.1 - 0.049 13.6 0.0 0.25 11.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, C-terminal domain DUF2110 PF09883.9 CCM04209.1 - 0.086 12.4 1.4 0.52 9.9 0.0 3.0 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2110) TPR_6 PF13174.6 CCM04209.1 - 0.18 12.5 0.1 31 5.5 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Suf PF05843.14 CCM04209.1 - 0.22 11.5 0.0 0.22 11.5 0.0 4.1 3 2 0 4 4 4 0 Suppressor of forked protein (Suf) TPR_10 PF13374.6 CCM04209.1 - 6.6 6.7 6.3 66 3.6 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 CCM04209.1 - 7.8 6.5 7.8 3.8 7.5 0.1 4.6 5 0 0 5 5 5 0 RNase II-type exonuclease C-terminal S1 domain Kelch_3 PF13415.6 CCM04210.1 - 6.8e-33 112.3 10.9 3.4e-06 27.2 0.1 6.9 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CCM04210.1 - 5.8e-32 109.1 4.4 4.2e-08 33.0 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 CCM04210.1 - 7.7e-31 105.9 12.0 4.9e-07 29.6 0.0 6.8 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 CCM04210.1 - 3.1e-28 97.1 2.9 3.4e-07 30.3 0.0 6.6 4 2 2 6 6 6 6 Kelch motif Kelch_1 PF01344.25 CCM04210.1 - 1.4e-24 85.4 2.3 1.3e-06 27.8 0.4 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 CCM04210.1 - 6.8e-24 82.9 7.0 2.9e-05 23.9 0.3 6.8 6 0 0 6 6 6 5 Kelch motif Cnn_1N PF07989.11 CCM04210.1 - 0.0011 19.0 5.8 0.0011 19.0 5.8 8.3 8 3 2 10 10 10 1 Centrosomin N-terminal motif 1 DUF2563 PF10817.8 CCM04210.1 - 0.13 12.9 1.7 0.36 11.5 1.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2563) Vac_Fusion PF02346.16 CCM04210.1 - 0.46 10.1 5.1 16 5.2 0.0 3.7 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Chibby PF14645.6 CCM04210.1 - 1.5 9.2 7.4 5.2 7.5 0.7 3.7 2 1 0 2 2 2 0 Chibby family RabGAP-TBC PF00566.18 CCM04212.1 - 8.7e-50 169.3 0.0 1.5e-49 168.6 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain COX6B PF02297.17 CCM04213.1 - 1.2e-21 76.8 1.2 1.5e-21 76.4 1.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Tiam_CC_Ex PF18385.1 CCM04213.1 - 0.094 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 T-lymphoma invasion and metastasis CC-Ex domain DAP3 PF10236.9 CCM04213.1 - 0.2 10.8 0.0 0.2 10.8 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Aldedh PF00171.22 CCM04215.1 - 1.1e-83 281.3 0.0 1.3e-83 281.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family BCS1_N PF08740.11 CCM04217.1 - 3.5e-46 157.6 3.7 4.7e-46 157.1 3.7 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CCM04217.1 - 3.6e-17 63.0 0.0 6.9e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM04217.1 - 0.00027 21.4 0.1 0.0013 19.2 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CCM04217.1 - 0.0014 18.8 0.0 0.0073 16.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CCM04217.1 - 0.0032 17.2 0.0 0.0081 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CCM04217.1 - 0.0033 17.0 0.0 0.01 15.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 CCM04217.1 - 0.0036 16.5 0.0 0.0057 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 CCM04217.1 - 0.013 15.5 0.0 0.041 13.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 CCM04217.1 - 0.019 15.5 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCM04217.1 - 0.036 14.5 0.0 0.071 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 CCM04217.1 - 0.061 13.9 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCM04217.1 - 0.081 13.4 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_21 PF13304.6 CCM04217.1 - 0.094 12.5 0.1 0.22 11.3 0.1 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CCM04217.1 - 0.11 12.4 0.0 0.91 9.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain Viral_helicase1 PF01443.18 CCM04217.1 - 0.12 12.1 0.0 0.34 10.6 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CCM04217.1 - 0.12 12.6 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CCM04217.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCM04217.1 - 0.19 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF3810 PF12725.7 CCM04218.1 - 1.1 8.5 12.0 0.33 10.3 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) MBOAT PF03062.19 CCM04219.1 - 2.4e-29 102.8 22.4 4.9e-26 91.9 13.3 2.4 1 1 1 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family CK_II_beta PF01214.18 CCM04220.1 - 1.4e-79 266.1 0.0 1.7e-79 265.8 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Arrestin_N PF00339.29 CCM04221.1 - 0.00091 19.3 0.0 0.0024 17.9 0.0 1.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain KH_6 PF15985.5 CCM04221.1 - 0.062 13.7 0.3 0.14 12.5 0.3 1.6 1 0 0 1 1 1 0 KH domain TPR_1 PF00515.28 CCM04222.1 - 1e-12 47.3 6.1 3.6e-05 23.4 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM04222.1 - 1.3e-11 44.0 0.7 0.00023 20.8 0.0 2.6 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.17 CCM04222.1 - 5.7e-11 41.7 7.5 0.00017 21.5 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM04222.1 - 5.3e-10 39.8 6.8 2.3e-06 28.2 4.6 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM04222.1 - 5.4e-10 39.6 4.3 1.1e-06 29.0 3.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM04222.1 - 5.9e-08 32.9 7.9 0.0018 18.9 0.1 3.8 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM04222.1 - 1.2e-07 31.3 2.4 0.051 13.8 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 CCM04222.1 - 0.00011 22.6 1.5 0.24 12.1 0.1 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CCM04222.1 - 0.00046 20.0 3.9 0.018 15.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM04222.1 - 0.00086 19.5 9.0 0.12 12.7 4.2 3.6 1 1 2 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCM04222.1 - 0.0019 18.2 3.0 0.92 9.6 0.8 3.4 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 CCM04222.1 - 0.004 17.3 2.3 0.071 13.3 1.6 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCM04222.1 - 0.068 13.1 7.2 0.79 9.7 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Metallophos PF00149.28 CCM04223.1 - 2e-09 38.3 0.1 7.3e-09 36.4 0.0 1.9 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCM04223.1 - 1.4e-05 25.3 0.0 3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain HSP20 PF00011.21 CCM04224.1 - 1.8e-05 24.8 0.2 3.6e-05 23.8 0.2 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family YkyA PF10368.9 CCM04224.1 - 0.027 14.1 8.8 0.039 13.6 8.8 1.2 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein UvrD-helicase PF00580.21 CCM04225.1 - 3.1e-64 217.5 0.0 4.9e-64 216.8 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CCM04225.1 - 1e-54 186.3 0.0 2e-53 182.0 0.0 2.2 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CCM04225.1 - 5.5e-34 117.6 0.0 1.4e-33 116.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CCM04225.1 - 2.9e-12 46.2 0.0 7.6e-12 44.9 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CCM04225.1 - 1e-07 31.9 0.0 0.00014 21.7 0.0 2.5 1 1 1 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CCM04225.1 - 1.9e-05 24.5 3.4 0.087 12.5 0.0 3.6 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 CCM04225.1 - 0.00072 19.4 0.1 0.0019 18.1 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CCM04225.1 - 0.0028 17.3 0.0 0.028 14.0 0.0 2.6 4 0 0 4 4 4 1 AAA domain DUF1846 PF08903.11 CCM04225.1 - 0.15 10.5 0.2 0.23 9.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) Sugar_tr PF00083.24 CCM04226.1 - 9.6e-119 397.2 23.9 1.5e-118 396.5 23.9 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM04226.1 - 1.9e-24 86.3 46.6 4.2e-18 65.4 17.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_C14 PF00656.22 CCM04227.1 - 3.8e-62 210.5 0.0 4.6e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DFRP_C PF16543.5 CCM04228.1 - 0.039 14.5 0.0 0.076 13.5 0.0 1.4 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 Abhydrolase_1 PF00561.20 CCM04229.1 - 0.062 12.9 0.0 0.062 12.9 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold TMEM119 PF15724.5 CCM04230.1 - 0.11 12.5 3.0 0.26 11.3 3.0 1.5 1 0 0 1 1 1 0 TMEM119 family SAM_PNT PF02198.16 CCM04231.1 - 0.00068 19.6 0.1 0.0011 18.9 0.1 1.3 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Cupin_1 PF00190.22 CCM04232.1 - 3.8e-41 140.2 0.1 2.4e-19 69.4 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCM04232.1 - 3.2e-27 94.0 0.6 1.4e-12 47.1 0.3 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCM04232.1 - 1.1e-08 34.7 0.1 0.00035 20.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCM04232.1 - 7.5e-05 22.6 0.1 0.0019 18.1 0.0 2.3 2 0 0 2 2 2 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCM04232.1 - 0.00031 20.7 0.0 0.0022 17.9 0.0 1.9 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase 3-HAO PF06052.12 CCM04232.1 - 0.0074 15.9 0.0 0.098 12.3 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase Cupin_4 PF08007.12 CCM04232.1 - 0.1 12.0 0.1 0.75 9.2 0.0 1.9 2 0 0 2 2 2 0 Cupin superfamily protein Pirin_C PF05726.13 CCM04232.1 - 0.12 12.7 0.0 6.9 7.1 0.0 2.5 2 0 0 2 2 2 0 Pirin C-terminal cupin domain ARD PF03079.14 CCM04232.1 - 0.13 12.4 0.0 0.93 9.7 0.0 2.0 2 0 0 2 2 2 0 ARD/ARD' family UCH PF00443.29 CCM04233.1 - 2.1e-27 96.2 0.0 2.9e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM04233.1 - 3.2e-12 46.7 0.0 4.6e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CCM04233.1 - 0.0028 17.2 1.5 0.11 11.9 0.3 2.1 2 0 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase NOC3p PF07540.11 CCM04233.1 - 0.025 15.0 0.3 0.046 14.2 0.3 1.3 1 0 0 1 1 1 0 Nucleolar complex-associated protein C1_4 PF07975.12 CCM04233.1 - 0.65 10.3 4.1 1.3 9.3 1.2 2.3 2 0 0 2 2 2 0 TFIIH C1-like domain CDC45 PF02724.14 CCM04234.1 - 0.2 9.9 1.3 0.21 9.8 1.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Thg1C PF14413.6 CCM04235.1 - 3.3e-44 149.9 0.0 5.8e-44 149.2 0.0 1.4 2 0 0 2 2 2 1 Thg1 C terminal domain Thg1 PF04446.12 CCM04235.1 - 1.1e-25 90.0 0.1 1.6e-25 89.5 0.1 1.2 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Pterin_4a PF01329.19 CCM04236.1 - 4.3e-07 30.0 0.0 8.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase PSCyt3 PF07627.11 CCM04236.1 - 0.017 15.4 0.4 0.044 14.1 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) Forkhead PF00250.18 CCM04237.1 - 3e-29 101.1 0.1 5.9e-29 100.2 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain NAD_binding_4 PF07993.12 CCM04238.1 - 6.4e-27 94.3 0.0 1.8e-26 92.9 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 CCM04238.1 - 3.4e-24 85.2 0.0 1.4e-23 83.2 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CCM04238.1 - 1.2e-05 25.0 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM04238.1 - 0.06 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Phosphopantetheine attachment site Cerato-platanin PF07249.12 CCM04239.1 - 1.4e-49 167.1 6.9 1.3e-24 86.5 2.5 2.1 2 0 0 2 2 2 2 Cerato-platanin Pkinase PF00069.25 CCM04241.1 - 2.6e-25 89.3 0.0 3.3e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04241.1 - 3.8e-12 46.0 0.0 5e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM04241.1 - 3.9e-08 32.5 0.0 3.9e-08 32.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase DSBA PF01323.20 CCM04242.1 - 3e-31 108.7 0.0 4e-31 108.3 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CCM04242.1 - 5.9e-09 36.3 0.1 8.3e-08 32.6 0.0 2.1 1 1 0 2 2 2 1 Thioredoxin Thioredoxin_5 PF13743.6 CCM04242.1 - 0.00015 21.5 0.2 0.00025 20.8 0.2 1.4 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 CCM04242.1 - 0.027 14.5 0.0 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin domain mRNA_decap_C PF16741.5 CCM04242.1 - 0.16 11.3 0.1 1.3 8.4 0.0 2.3 3 0 0 3 3 3 0 mRNA-decapping enzyme C-terminus Frag1 PF10277.9 CCM04243.1 - 1.9e-39 135.5 19.4 2.3e-39 135.2 19.4 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Kinocilin PF15033.6 CCM04243.1 - 0.28 10.8 5.0 0.31 10.7 0.2 2.2 2 0 0 2 2 2 0 Kinocilin protein Vps51 PF08700.11 CCM04244.1 - 1.4e-23 82.7 1.2 2.1e-23 82.2 1.2 1.2 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 CCM04244.1 - 0.0016 17.2 1.3 0.0022 16.8 1.3 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 CCM04244.1 - 0.0036 17.5 1.9 0.0054 16.9 1.9 1.2 1 0 0 1 1 1 1 Golgi transport complex subunit 5 FlgN PF05130.12 CCM04244.1 - 0.028 14.9 1.1 0.039 14.5 1.1 1.2 1 0 0 1 1 1 0 FlgN protein Aldedh PF00171.22 CCM04245.1 - 1.1e-111 373.7 0.5 1.4e-111 373.3 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCM04245.1 - 0.00034 19.8 0.2 0.0046 16.0 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA reductase (LuxC) NTP_transf_9 PF04248.12 CCM04246.1 - 5.3e-37 125.6 0.8 7.3e-30 102.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF427) Epimerase PF01370.21 CCM04248.1 - 6.6e-24 84.7 0.1 9.2e-24 84.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04248.1 - 2.5e-14 53.0 0.0 3.8e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM04248.1 - 2.7e-12 46.4 0.1 4.8e-11 42.3 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 CCM04248.1 - 8.1e-12 45.2 0.1 1.8e-11 44.0 0.1 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCM04248.1 - 4.1e-11 43.1 0.7 6.3e-11 42.5 0.7 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCM04248.1 - 2.4e-06 27.3 0.1 4.5e-06 26.4 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCM04248.1 - 0.00011 21.8 1.2 0.00056 19.4 0.4 2.3 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CCM04248.1 - 0.0012 18.0 0.1 0.0017 17.6 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCM04248.1 - 0.0032 17.4 0.2 0.044 13.7 0.2 2.3 1 1 0 1 1 1 1 KR domain DUF3253 PF11625.8 CCM04248.1 - 0.06 13.6 0.8 0.63 10.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3253) Epimerase PF01370.21 CCM04249.1 - 3.1e-22 79.2 0.1 4.9e-22 78.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04249.1 - 2.4e-14 53.0 0.0 4.9e-14 52.0 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM04249.1 - 1.1e-10 41.1 0.1 9.1e-09 34.8 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCM04249.1 - 1.6e-10 41.2 2.1 2.9e-10 40.3 2.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCM04249.1 - 3e-10 40.0 0.3 3.2e-08 33.4 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCM04249.1 - 8.8e-06 25.1 0.2 1.6e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CCM04249.1 - 3.2e-05 23.6 0.6 6.8e-05 22.5 0.5 1.7 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 CCM04249.1 - 0.0083 15.2 0.1 0.9 8.6 0.1 2.5 2 1 0 2 2 2 1 RmlD substrate binding domain adh_short PF00106.25 CCM04249.1 - 0.022 14.2 1.5 0.069 12.6 0.2 2.3 3 0 0 3 3 3 0 short chain dehydrogenase KR PF08659.10 CCM04249.1 - 0.075 12.9 0.5 1.9 8.4 0.5 2.2 1 1 0 1 1 1 0 KR domain Epimerase PF01370.21 CCM04250.1 - 5.9e-26 91.4 0.0 7.9e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04250.1 - 1.7e-18 66.7 0.0 2.2e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCM04250.1 - 5.9e-13 48.9 0.0 1e-11 44.9 0.0 2.2 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCM04250.1 - 6.6e-11 41.9 0.0 7.6e-09 35.1 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCM04250.1 - 1.4e-10 41.4 0.0 2e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCM04250.1 - 1.4e-06 28.0 0.1 2.3e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CCM04250.1 - 0.0012 18.0 0.1 0.0021 17.2 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein UPF0020 PF01170.18 CCM04250.1 - 0.0015 18.2 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 RmlD_sub_bind PF04321.17 CCM04250.1 - 0.0067 15.6 0.1 0.12 11.4 0.0 2.3 2 1 0 2 2 2 1 RmlD substrate binding domain KR PF08659.10 CCM04250.1 - 0.018 14.9 0.1 0.52 10.2 0.1 2.2 1 1 0 1 1 1 0 KR domain adh_short PF00106.25 CCM04250.1 - 0.026 14.0 0.1 0.062 12.8 0.2 1.7 1 1 0 1 1 1 0 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 CCM04250.1 - 0.072 13.4 0.1 0.16 12.2 0.1 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CCM04251.1 - 4.7e-21 75.4 0.1 8.3e-21 74.5 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04251.1 - 5e-17 61.8 0.0 7.8e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCM04251.1 - 1.2e-11 44.6 0.2 2.2e-09 37.2 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CCM04251.1 - 7.7e-11 42.2 0.5 1.8e-10 41.0 0.2 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCM04251.1 - 1.4e-09 37.5 0.2 2.9e-08 33.2 0.2 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 CCM04251.1 - 4e-06 26.6 0.1 3.4e-05 23.5 0.1 2.1 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 CCM04251.1 - 0.00024 20.6 2.3 0.00061 19.3 0.2 2.7 2 1 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CCM04251.1 - 0.00044 19.5 0.1 0.0007 18.8 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCM04251.1 - 0.002 18.1 0.3 0.011 15.7 0.3 2.1 1 1 0 1 1 1 1 KR domain Pkinase PF00069.25 CCM04252.1 - 3.2e-43 148.0 0.0 4.5e-24 85.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04252.1 - 2.9e-22 79.2 0.0 2.1e-11 43.6 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCM04252.1 - 5.3e-07 29.3 0.0 0.0024 17.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CCM04252.1 - 0.00015 21.8 0.3 0.0013 18.8 0.3 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family RNB PF00773.19 CCM04254.1 - 7.8e-50 170.0 0.0 2.7e-49 168.3 0.0 1.9 2 1 0 2 2 2 1 RNB domain DUF3954 PF13128.6 CCM04254.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3954) p450 PF00067.22 CCM04255.1 - 2.6e-69 234.2 0.0 3.3e-69 233.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ATP_synt_H PF05493.13 CCM04256.1 - 4.5e-22 78.3 2.9 5.4e-22 78.0 2.9 1.0 1 0 0 1 1 1 1 ATP synthase subunit H DUF4131 PF13567.6 CCM04256.1 - 0.0022 17.7 1.7 0.0025 17.5 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) HisKA_7TM PF16927.5 CCM04256.1 - 0.0023 18.0 0.8 0.0025 17.9 0.8 1.0 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase Phage_holin_3_6 PF07332.11 CCM04256.1 - 0.0046 17.0 0.9 0.0055 16.7 0.9 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III Exosortase_EpsH PF09721.10 CCM04256.1 - 0.015 14.8 2.9 0.016 14.7 2.9 1.0 1 0 0 1 1 1 0 Transmembrane exosortase (Exosortase_EpsH) E1-E2_ATPase PF00122.20 CCM04256.1 - 0.092 12.3 0.8 0.099 12.2 0.8 1.0 1 0 0 1 1 1 0 E1-E2 ATPase Ndc1_Nup PF09531.10 CCM04256.1 - 0.19 10.4 1.4 0.2 10.3 1.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4307 PF14155.6 CCM04256.1 - 0.93 9.4 4.5 0.35 10.7 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) Methyltransf_23 PF13489.6 CCM04257.1 - 3e-05 23.9 0.0 6.7e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM04257.1 - 0.00016 22.3 0.0 0.25 12.1 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04257.1 - 0.004 17.8 0.0 0.22 12.2 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM04257.1 - 0.011 15.5 0.1 0.9 9.3 0.2 2.3 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 CCM04257.1 - 0.097 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 CCM04257.1 - 0.13 13.0 0.0 1.6 9.5 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain zf-C3HC PF07967.13 CCM04258.1 - 2.2e-28 98.9 0.0 7e-24 84.4 0.0 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 CCM04258.1 - 5.6e-17 61.7 0.4 2.4e-11 43.6 0.0 3.1 3 0 0 3 3 3 2 Rsm1-like DM PF00751.18 CCM04258.1 - 2.2 8.3 5.1 12 5.9 0.1 2.8 3 0 0 3 3 3 0 DM DNA binding domain DUF2370 PF10176.9 CCM04259.1 - 7.5e-61 205.6 0.0 1.4e-60 204.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) SLAC1 PF03595.17 CCM04259.1 - 0.00047 19.5 0.2 0.0037 16.6 0.1 1.9 2 0 0 2 2 2 1 Voltage-dependent anion channel CYYR1 PF10873.8 CCM04259.1 - 1.5 9.2 5.2 0.63 10.5 1.6 2.1 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Epimerase PF01370.21 CCM04261.1 - 9.3e-20 71.1 0.0 1.4e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCM04261.1 - 6.1e-10 38.7 0.1 2.4e-07 30.2 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CCM04261.1 - 2.3e-08 34.2 1.3 3.9e-08 33.4 1.3 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CCM04261.1 - 7.2e-08 31.8 0.0 1.4e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCM04261.1 - 5.2e-06 26.1 0.5 0.00034 20.1 0.1 2.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCM04261.1 - 0.0047 16.5 0.6 0.011 15.4 0.3 1.6 1 1 0 2 2 2 1 NmrA-like family TrmO PF01980.16 CCM04261.1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 tRNA-methyltransferase O F-box-like PF12937.7 CCM04262.1 - 0.043 13.7 0.0 0.13 12.1 0.0 1.9 1 0 0 1 1 1 0 F-box-like Epimerase PF01370.21 CCM04264.1 - 2.4e-24 86.1 0.1 9.2e-20 71.1 0.1 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM04264.1 - 9.4e-18 64.2 0.0 1.8e-15 56.7 0.0 2.5 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM04264.1 - 1.6e-11 43.9 0.4 1.5e-10 40.7 0.4 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CCM04264.1 - 4.8e-11 42.9 1.3 1e-10 41.8 1.3 1.6 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCM04264.1 - 5.8e-10 39.1 0.2 8.6e-09 35.2 0.0 2.7 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase UPF0020 PF01170.18 CCM04264.1 - 5.4e-06 26.2 0.0 0.12 12.0 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 NmrA PF05368.13 CCM04264.1 - 4.1e-05 23.3 0.3 0.0001 22.0 0.3 1.7 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CCM04264.1 - 0.00064 18.9 0.1 0.0011 18.2 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CCM04264.1 - 0.00074 19.0 1.8 0.0026 17.3 0.9 2.3 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCM04264.1 - 0.0023 17.9 0.5 0.022 14.7 0.5 2.1 1 1 0 1 1 1 1 KR domain Cons_hypoth95 PF03602.15 CCM04264.1 - 0.0036 17.0 0.0 0.77 9.4 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Sorb PF02208.16 CCM04264.1 - 0.033 14.0 0.0 8.6 6.3 0.0 2.5 2 0 0 2 2 2 0 Sorbin homologous domain SBP_bac_1 PF01547.25 CCM04264.1 - 0.056 13.4 6.4 2.8 7.8 0.1 2.8 3 1 0 3 3 3 0 Bacterial extracellular solute-binding protein adh_short_C2 PF13561.6 CCM04264.1 - 0.15 11.6 1.2 0.72 9.4 0.5 2.4 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Glyco_transf_20 PF00982.21 CCM04265.1 - 5.5e-187 622.2 0.0 2e-186 620.3 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 CCM04265.1 - 0.00032 21.1 0.1 0.00065 20.1 0.1 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CCM04265.1 - 0.044 13.3 0.4 5.8 6.4 0.0 2.8 2 1 0 2 2 2 0 Glycosyl transferases group 1 DNA_pol3_delta2 PF13177.6 CCM04266.1 - 2.8e-12 46.7 0.0 4.1e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 CCM04266.1 - 4.1e-07 30.5 0.4 8.1e-07 29.5 0.4 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCM04266.1 - 3.7e-05 23.7 0.0 7.1e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 CCM04266.1 - 0.00064 19.5 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 CCM04266.1 - 0.0008 19.7 0.1 0.0022 18.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CCM04266.1 - 0.0022 17.4 0.2 0.0086 15.5 0.2 1.9 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CCM04266.1 - 0.0042 17.5 0.1 0.012 16.0 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 CCM04266.1 - 0.0067 16.2 0.1 0.017 14.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CCM04266.1 - 0.011 15.5 0.1 0.36 10.6 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CCM04266.1 - 0.011 15.8 0.1 0.018 15.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_assoc_2 PF16193.5 CCM04266.1 - 0.015 15.6 0.2 0.039 14.3 0.1 1.8 2 0 0 2 2 2 0 AAA C-terminal domain AAA_19 PF13245.6 CCM04266.1 - 0.076 13.4 0.3 0.33 11.3 0.2 2.1 1 1 1 2 2 2 0 AAA domain T4SS-DNA_transf PF02534.14 CCM04266.1 - 0.078 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_29 PF13555.6 CCM04266.1 - 0.093 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Bac_DnaA PF00308.18 CCM04266.1 - 0.26 11.1 1.6 6 6.6 1.6 2.4 1 1 0 1 1 1 0 Bacterial dnaA protein Ank_3 PF13606.6 CCM04267.1 - 2.9e-08 33.3 1.0 7e-06 26.0 0.0 4.6 5 0 0 5 5 5 1 Ankyrin repeat zf-MYND PF01753.18 CCM04267.1 - 1.8e-07 31.1 13.5 1.8e-07 31.1 13.5 1.9 2 0 0 2 2 2 1 MYND finger Ank_5 PF13857.6 CCM04267.1 - 2.6e-06 27.6 0.1 0.00062 20.0 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM04267.1 - 3.4e-06 27.6 0.1 0.00059 20.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 CCM04267.1 - 3.6e-06 27.2 2.5 0.00058 20.2 0.0 4.0 3 1 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 CCM04267.1 - 2.1e-05 24.9 0.1 0.00018 22.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) SEC-C PF02810.15 CCM04267.1 - 0.019 14.9 2.6 0.019 14.9 2.6 3.4 3 0 0 3 3 3 0 SEC-C motif zf-C6H2 PF15801.5 CCM04267.1 - 0.56 10.6 10.7 1.3 9.4 10.7 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding PNP_UDP_1 PF01048.20 CCM04268.1 - 3.8e-28 98.3 0.0 4.6e-28 98.1 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Glyco_tran_WecB PF03808.13 CCM04268.1 - 0.087 12.8 0.0 0.27 11.2 0.0 1.9 2 1 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family HMG_box PF00505.19 CCM04269.1 - 1.8e-15 57.1 2.1 3.3e-15 56.2 2.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM04269.1 - 7.1e-14 52.2 0.7 1.4e-13 51.2 0.7 1.5 1 0 0 1 1 1 1 HMG-box domain adh_short_C2 PF13561.6 CCM04270.1 - 1.8e-44 152.1 1.3 2.3e-44 151.7 1.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM04270.1 - 3.9e-27 95.0 1.1 4.8e-27 94.7 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM04270.1 - 1.9e-05 24.6 0.2 4.3e-05 23.5 0.2 1.5 1 0 0 1 1 1 1 KR domain His_biosynth PF00977.21 CCM04270.1 - 0.098 12.1 0.3 0.22 11.0 0.0 1.7 3 0 0 3 3 3 0 Histidine biosynthesis protein Glyco_hydro_31 PF01055.26 CCM04271.1 - 6.3e-143 477.1 1.6 8.2e-143 476.8 1.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CCM04271.1 - 1.7e-26 92.7 0.0 3.1e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CCM04271.1 - 3.7e-05 23.9 0.1 0.00011 22.4 0.1 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like Lipocalin_4 PF13648.6 CCM04271.1 - 0.0045 17.9 0.0 0.016 16.1 0.0 1.9 1 0 0 1 1 1 1 Lipocalin-like domain F-box-like PF12937.7 CCM04274.1 - 0.037 13.9 0.9 0.037 13.9 0.9 3.2 3 0 0 3 3 3 0 F-box-like F-box-like PF12937.7 CCM04275.1 - 0.0069 16.3 1.1 0.016 15.0 1.1 1.7 1 0 0 1 1 1 1 F-box-like p450 PF00067.22 CCM04276.1 - 8.9e-62 209.3 0.0 2.5e-61 207.8 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 CCM04276.1 - 2.2e-05 24.3 1.1 8.4e-05 22.4 1.1 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM04276.1 - 0.052 13.4 2.1 0.097 12.6 0.0 2.6 3 0 0 3 3 3 0 F-box domain p450 PF00067.22 CCM04277.1 - 6.3e-58 196.6 0.0 1.1e-57 195.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 CCM04278.1 - 0.086 12.8 4.4 0.076 12.9 2.5 2.0 2 0 0 2 2 2 0 F-box-like AAA_12 PF13087.6 CCM04279.1 - 1.9e-36 125.5 0.0 4.8e-36 124.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCM04279.1 - 2.7e-23 83.1 0.1 3.9e-22 79.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCM04279.1 - 7e-08 32.9 0.1 1.3e-06 28.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CCM04279.1 - 1.3e-07 31.5 1.0 1.1e-06 28.5 0.0 2.9 3 1 0 3 3 3 1 AAA domain zf-CCCH PF00642.24 CCM04279.1 - 2.6e-06 27.2 9.4 6.8e-05 22.7 1.5 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCM04279.1 - 1.9e-05 24.3 8.3 2.8e-05 23.8 1.9 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCM04279.1 - 2.9e-05 23.9 12.5 6.8e-05 22.8 4.1 2.5 2 0 0 2 2 2 1 Zinc finger domain Torus PF16131.5 CCM04279.1 - 0.00035 21.3 0.3 1.3 9.7 0.1 2.5 2 0 0 2 2 2 2 Torus domain DUF2075 PF09848.9 CCM04279.1 - 0.00071 18.9 0.0 0.2 10.8 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 CCM04279.1 - 0.0049 17.3 0.0 0.027 14.9 0.0 2.3 1 0 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.6 CCM04279.1 - 0.027 14.3 0.0 0.067 13.0 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_5 PF07728.14 CCM04279.1 - 0.046 13.7 0.0 0.2 11.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CCM04279.1 - 0.091 13.2 0.0 0.25 11.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCM04279.1 - 0.099 12.9 0.1 0.71 10.1 0.0 2.5 3 0 0 3 3 2 0 AAA domain Viral_helicase1 PF01443.18 CCM04279.1 - 0.13 12.0 0.0 30 4.2 0.0 3.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase CtsR PF05848.11 CCM04279.1 - 0.17 11.8 0.1 0.83 9.6 0.0 2.2 2 0 0 2 2 2 0 CtsR N-terminal HTH domain TMEM51 PF15345.6 CCM04280.1 - 0.046 13.6 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 Transmembrane protein 51 Mlf1IP PF10248.9 CCM04280.1 - 0.23 11.4 4.0 0.42 10.6 4.0 1.4 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein Brix PF04427.18 CCM04281.1 - 1.5e-42 145.9 0.0 2.4e-42 145.2 0.0 1.3 1 0 0 1 1 1 1 Brix domain DBR1 PF05011.13 CCM04282.1 - 5.6e-41 140.2 0.1 9.2e-41 139.5 0.1 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 CCM04282.1 - 0.046 14.2 1.7 0.055 14.0 0.8 1.6 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase DUF3328 PF11807.8 CCM04285.1 - 8.3e-53 179.4 0.4 1.3e-52 178.8 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF2681 PF10883.8 CCM04286.1 - 0.015 15.7 0.1 0.025 15.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) GFO_IDH_MocA PF01408.22 CCM04289.1 - 4.8e-05 24.2 0.0 9.8e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Peptidase_C13 PF01650.18 CCM04290.1 - 2.7e-44 151.6 0.3 3.8e-44 151.1 0.3 1.2 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 CCM04290.1 - 0.084 13.1 0.4 0.37 11.1 0.1 2.3 2 1 0 2 2 2 0 Mid domain of argonaute HAMP PF00672.25 CCM04291.1 - 6.7e-42 141.7 27.3 3e-07 30.7 0.1 9.0 8 2 1 9 9 9 7 HAMP domain HATPase_c PF02518.26 CCM04291.1 - 4.6e-29 101.2 0.1 1.3e-28 99.7 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CCM04291.1 - 3.1e-25 88.5 0.6 6.4e-24 84.3 0.2 2.8 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CCM04291.1 - 3.2e-17 62.3 1.1 1.4e-16 60.2 1.1 2.3 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain DUF4795 PF16043.5 CCM04291.1 - 0.0013 18.4 0.5 13 5.3 0.1 4.4 2 1 1 4 4 4 1 Domain of unknown function (DUF4795) Baculo_PEP_C PF04513.12 CCM04291.1 - 0.0034 17.4 30.0 0.77 9.8 0.1 7.2 1 1 4 6 6 6 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3829 PF12889.7 CCM04291.1 - 0.13 11.8 1.0 31 3.9 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3829) zf-ribbon_3 PF13248.6 CCM04291.1 - 0.16 11.4 0.2 0.33 10.4 0.2 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 CCM04291.1 - 0.23 11.2 0.1 0.57 10.0 0.1 1.7 1 0 0 1 1 1 0 zinc-ribbon domain F-box-like_2 PF13013.6 CCM04293.1 - 0.0019 18.2 0.1 0.0048 16.8 0.1 1.7 1 1 0 1 1 1 1 F-box-like domain F-box-like PF12937.7 CCM04293.1 - 0.038 13.9 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 F-box-like DEAD PF00270.29 CCM04294.1 - 6.2e-29 101.0 0.0 1.7e-28 99.6 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM04294.1 - 1.2e-20 73.9 0.0 6.8e-20 71.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM04294.1 - 1.7e-07 31.4 0.0 5.2e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCM04294.1 - 0.0024 18.2 0.0 0.0048 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CCM04294.1 - 2.5 8.4 6.9 0.72 10.1 1.3 2.7 2 1 0 2 2 2 0 AAA domain XLF PF09302.11 CCM04295.1 - 3.3e-09 37.2 0.1 6e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component TFIIF_alpha PF05793.12 CCM04295.1 - 3 6.3 13.9 4.2 5.8 13.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) G-patch PF01585.23 CCM04296.1 - 3.5e-09 36.4 0.9 8e-09 35.3 0.9 1.7 1 0 0 1 1 1 1 G-patch domain FHA PF00498.26 CCM04296.1 - 4.3e-09 36.6 0.0 1.3e-08 35.0 0.0 1.8 2 0 0 2 2 2 1 FHA domain G-patch_2 PF12656.7 CCM04296.1 - 0.025 14.7 0.1 0.052 13.6 0.1 1.5 1 0 0 1 1 1 0 G-patch domain Yop-YscD_cpl PF16697.5 CCM04296.1 - 0.025 14.9 0.0 0.38 11.1 0.0 2.5 3 0 0 3 3 3 0 Inner membrane component of T3SS, cytoplasmic domain LRR_4 PF12799.7 CCM04297.1 - 0.0034 17.8 1.4 0.3 11.6 0.1 3.5 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) F-box-like PF12937.7 CCM04297.1 - 0.0044 16.9 1.0 0.0044 16.9 1.0 2.2 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 CCM04297.1 - 0.15 12.2 1.6 11 6.4 0.1 4.3 5 0 0 5 5 5 0 Leucine Rich repeat DUF1736 PF08409.11 CCM04298.1 - 0.15 12.1 0.1 0.36 10.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1736) Na_Ca_ex PF01699.24 CCM04299.1 - 1.5e-40 138.6 39.1 1.3e-20 73.9 13.6 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein adh_short PF00106.25 CCM04300.1 - 2.5e-82 275.1 22.9 3.1e-42 144.2 3.9 2.8 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04300.1 - 4.7e-63 212.9 25.2 2.2e-32 112.5 10.1 3.4 3 1 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 CCM04300.1 - 6.7e-31 106.4 0.0 2e-30 104.9 0.0 1.8 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 CCM04300.1 - 6.6e-27 94.6 14.1 4.5e-14 52.8 2.3 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydrat_N PF13452.6 CCM04300.1 - 8.9e-06 25.9 0.0 0.00022 21.4 0.0 2.4 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase 3HCDH_N PF02737.18 CCM04300.1 - 0.0027 17.6 10.7 0.17 11.8 1.5 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 CCM04300.1 - 0.021 14.1 2.5 2.8 7.2 0.5 2.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CoA_binding PF02629.19 CCM04300.1 - 0.069 13.8 2.6 1.1 10.0 0.1 3.1 2 0 0 2 2 2 0 CoA binding domain DUF543 PF04418.12 CCM04300.1 - 4.9 7.2 7.6 19 5.3 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF543) PRK PF00485.18 CCM04301.1 - 1.6e-48 165.1 0.0 2.2e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 CCM04301.1 - 3.2e-48 163.9 0.0 4.1e-46 157.1 0.0 2.2 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase AAA_33 PF13671.6 CCM04301.1 - 3.8e-05 23.9 0.0 9e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCM04301.1 - 0.0006 20.4 0.0 0.0014 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CCM04301.1 - 0.0043 16.3 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 CCM04301.1 - 0.0092 16.4 0.3 2.9 8.3 0.1 2.4 2 0 0 2 2 2 2 AAA domain CoaE PF01121.20 CCM04301.1 - 0.038 13.7 0.2 0.3 10.8 0.1 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase dNK PF01712.19 CCM04301.1 - 0.1 12.4 0.1 0.58 10.0 0.0 2.1 2 1 0 2 2 2 0 Deoxynucleoside kinase Alpha-amylase_C PF02806.18 CCM04302.1 - 0.092 13.2 0.1 0.32 11.5 0.1 1.9 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain DUF908 PF06012.12 CCM04303.1 - 8.6 5.7 9.9 9.2 5.6 9.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) PRMT5_TIM PF17285.2 CCM04304.1 - 7.5e-70 235.0 0.0 1.1e-69 234.6 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 CCM04304.1 - 8.7e-64 214.5 0.0 2.3e-63 213.1 0.0 1.6 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 CCM04304.1 - 1.1e-53 181.8 0.0 1.6e-53 181.2 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Ank_4 PF13637.6 CCM04304.1 - 1.3e-13 51.2 0.0 9.6e-06 26.1 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCM04304.1 - 5.3e-11 42.5 0.0 3.5e-09 36.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM04304.1 - 1.4e-08 35.2 0.0 3.3e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCM04304.1 - 3.9e-06 26.8 0.0 0.00082 19.7 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 CCM04304.1 - 3.9e-06 27.1 0.0 0.012 16.0 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Methyltransf_25 PF13649.6 CCM04304.1 - 0.0049 17.6 0.0 0.011 16.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04304.1 - 0.13 12.9 0.0 0.3 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain GATA PF00320.27 CCM04305.1 - 8.3e-14 50.9 3.1 1.8e-13 49.8 3.1 1.6 1 0 0 1 1 1 1 GATA zinc finger LRR_4 PF12799.7 CCM04306.1 - 4e-35 119.3 21.9 1.2e-08 35.0 0.4 7.2 4 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCM04306.1 - 1.1e-25 89.1 23.3 1.6e-13 50.2 0.7 5.9 3 2 4 7 7 7 6 Leucine rich repeat LRR_9 PF14580.6 CCM04306.1 - 7.5e-25 87.4 11.0 4.1e-10 39.4 0.4 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 CCM04306.1 - 1.2e-07 31.3 20.5 11 7.0 0.1 9.5 9 1 0 9 9 9 3 Leucine Rich Repeat LRR_6 PF13516.6 CCM04306.1 - 0.00045 20.1 20.1 3.4 8.0 0.2 7.9 10 0 0 10 10 10 3 Leucine Rich repeat DUF4078 PF13300.6 CCM04307.1 - 1e-18 67.4 3.8 1e-18 67.4 3.8 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) DUF1180 PF06679.12 CCM04307.1 - 0.47 10.8 7.8 1.8 9.0 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1180) Acyl-thio_N PF12590.8 CCM04307.1 - 0.78 10.3 3.3 0.37 11.4 0.4 2.0 2 0 0 2 2 2 0 Acyl-ATP thioesterase Rrn6 PF10214.9 CCM04307.1 - 5.8 5.3 7.3 9 4.6 7.3 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Lactamase_B PF00753.27 CCM04308.1 - 5.6e-08 33.0 2.8 0.00012 22.2 0.0 2.4 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCM04308.1 - 0.0055 16.2 0.6 0.023 14.2 0.6 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Tannase PF07519.11 CCM04309.1 - 1.6e-78 264.7 1.8 3.7e-78 263.5 1.8 1.5 1 1 0 1 1 1 1 Tannase and feruloyl esterase ThiS PF02597.20 CCM04309.1 - 8.5e-05 23.1 0.0 0.0007 20.2 0.0 2.4 2 0 0 2 2 2 1 ThiS family Hydrolase_4 PF12146.8 CCM04309.1 - 0.12 11.6 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 TPK_catalytic PF04263.16 CCM04310.1 - 4.5e-27 94.5 0.0 6.7e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 CCM04310.1 - 1.3e-19 69.7 0.4 1.8e-19 69.2 0.4 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Stealth_CR2 PF11380.8 CCM04310.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Stealth protein CR2, conserved region 2 CS PF04969.16 CCM04311.1 - 1.8e-08 35.3 0.0 3.2e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 CS domain DUF4597 PF15366.6 CCM04311.1 - 0.08 12.7 1.7 2.7 7.8 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) Cyclin_N PF00134.23 CCM04313.1 - 1.9e-42 144.0 0.3 4.2e-42 142.9 0.3 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CCM04313.1 - 3.7e-25 88.3 0.0 8e-25 87.2 0.0 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain BRI3BP PF14965.6 CCM04313.1 - 0.094 12.2 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Negative regulator of p53/TP53 HalX PF08663.10 CCM04313.1 - 0.61 10.4 4.6 0.13 12.6 0.8 1.8 2 0 0 2 2 2 0 HalX domain Tannase PF07519.11 CCM04314.1 - 1.5e-78 264.9 0.1 2.2e-78 264.3 0.1 1.3 1 0 0 1 1 1 1 Tannase and feruloyl esterase Tannase PF07519.11 CCM04315.1 - 2.1e-12 46.7 0.0 2.3e-12 46.6 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Steroid_dh PF02544.16 CCM04316.1 - 4.9e-35 120.7 6.1 7.9e-35 120.0 6.1 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 CCM04316.1 - 0.00049 19.8 0.0 0.00078 19.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family PEMT PF04191.13 CCM04316.1 - 0.019 15.3 0.4 0.045 14.2 0.4 1.7 1 0 0 1 1 1 0 Phospholipid methyltransferase DUF410 PF04190.13 CCM04317.1 - 4.4e-76 256.1 0.0 7e-76 255.4 0.0 1.3 2 0 0 2 2 2 1 Protein of unknown function (DUF410) HSBP1 PF06825.12 CCM04318.1 - 2.2e-19 69.0 3.6 2.7e-19 68.7 3.6 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 CCM04318.1 - 0.032 14.3 1.0 0.042 13.9 1.0 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CLZ PF16526.5 CCM04318.1 - 0.043 14.2 0.2 0.053 13.9 0.2 1.1 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BLOC1_2 PF10046.9 CCM04318.1 - 0.054 13.8 0.1 0.072 13.4 0.1 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FGAR-AT_N PF18076.1 CCM04318.1 - 0.084 12.9 0.2 0.12 12.4 0.2 1.2 1 0 0 1 1 1 0 Formylglycinamide ribonucleotide amidotransferase N-terminal Matrilin_ccoil PF10393.9 CCM04318.1 - 0.098 12.5 0.3 0.88 9.5 0.3 2.1 1 1 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin HalX PF08663.10 CCM04318.1 - 0.13 12.6 0.9 1.2 9.5 0.2 2.0 1 1 1 2 2 2 0 HalX domain FdhE PF04216.12 CCM04318.1 - 0.18 11.7 0.0 0.2 11.5 0.0 1.0 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation CCDC24 PF15669.5 CCM04318.1 - 5.7 6.8 7.1 12 5.7 3.5 2.0 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 24 family Gti1_Pac2 PF09729.9 CCM04319.1 - 3.3e-29 102.2 2.6 2.2e-20 73.5 0.3 2.5 1 1 1 2 2 2 2 Gti1/Pac2 family Tfb2 PF03849.14 CCM04320.1 - 1.7e-136 454.9 0.0 2e-136 454.6 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 CCM04320.1 - 3.1e-25 88.4 0.1 6.8e-25 87.3 0.1 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 CCM04320.1 - 0.00077 19.6 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GRIP PF01465.20 CCM04320.1 - 0.5 10.3 2.6 0.39 10.7 0.5 2.0 2 0 0 2 2 2 0 GRIP domain Ank_4 PF13637.6 CCM04321.1 - 1.2e-35 121.5 0.6 7.8e-13 48.7 0.0 5.8 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM04321.1 - 3.7e-34 117.1 0.1 4.6e-15 56.0 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM04321.1 - 1.2e-32 111.6 11.1 3.5e-11 43.1 0.1 5.8 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 CCM04321.1 - 4.4e-31 106.0 3.4 2.4e-09 37.2 0.0 6.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 CCM04321.1 - 1.4e-29 98.8 0.1 5.8e-07 29.3 0.0 5.6 6 0 0 6 6 6 4 Ankyrin repeat Aldo_ket_red PF00248.21 CCM04322.1 - 7.9e-44 150.0 0.0 1.3e-41 142.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family zf-RING_5 PF14634.6 CCM04323.1 - 0.0048 16.8 0.1 0.0084 16.0 0.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 CCM04323.1 - 0.16 11.7 0.2 0.65 9.8 0.0 2.0 2 0 0 2 2 2 0 RING-like zinc finger MFS_1 PF07690.16 CCM04325.1 - 2.3e-31 109.0 23.7 2.3e-31 109.0 23.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM04325.1 - 1.7e-06 27.2 20.3 1.5e-05 24.1 20.3 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter PetM PF08041.11 CCM04325.1 - 0.068 12.8 1.3 0.27 10.8 1.3 2.1 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Pertussis_S2S3 PF02918.15 CCM04327.1 - 0.035 14.0 0.5 0.068 13.1 0.3 1.5 1 1 1 2 2 2 0 Pertussis toxin, subunit 2 and 3, C-terminal domain adh_short_C2 PF13561.6 CCM04328.1 - 3.4e-49 167.5 0.9 5.1e-49 166.9 0.9 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM04328.1 - 1.3e-46 158.5 0.1 1.7e-46 158.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM04328.1 - 1.2e-08 35.0 0.0 2.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM04328.1 - 0.00049 19.6 0.1 0.00095 18.7 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCM04328.1 - 0.0012 18.8 0.1 0.027 14.4 0.0 2.3 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 CCM04328.1 - 0.0054 16.4 0.1 0.47 10.1 0.0 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA B12-binding PF02310.19 CCM04328.1 - 0.069 13.2 0.2 0.18 11.8 0.0 1.7 1 1 1 2 2 2 0 B12 binding domain DUF5568 PF17724.1 CCM04328.1 - 0.15 11.9 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5568) Transp_cyt_pur PF02133.15 CCM04329.1 - 6.4e-111 371.2 36.6 7.3e-111 371.0 36.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin BTB PF00651.31 CCM04331.1 - 2e-07 31.2 0.1 6e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 CCM04332.1 - 0.00024 21.3 0.0 0.00047 20.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain O-FucT PF10250.9 CCM04333.1 - 0.0017 18.2 0.0 0.0017 18.2 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase zf-C2H2 PF00096.26 CCM04336.1 - 2.5e-05 24.5 1.5 0.0025 18.2 0.1 3.5 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-BED PF02892.15 CCM04336.1 - 0.00078 19.4 0.9 0.64 10.1 0.2 2.6 2 0 0 2 2 2 2 BED zinc finger TRAF6_Z2 PF18048.1 CCM04336.1 - 0.0059 16.7 0.5 0.025 14.7 0.1 2.2 2 0 0 2 2 2 1 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_4 PF13894.6 CCM04336.1 - 0.018 15.8 0.1 0.018 15.8 0.1 4.1 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CCM04336.1 - 0.03 14.1 0.4 0.03 14.1 0.4 2.6 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 CCM04336.1 - 0.53 10.2 3.8 3 7.8 3.3 2.6 3 1 0 3 3 3 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 CCM04336.1 - 0.84 9.5 5.7 13 5.7 0.0 3.8 4 0 0 4 4 4 0 C2H2-type zinc-finger domain FOXP-CC PF16159.5 CCM04336.1 - 3.9 8.2 7.2 0.98 10.1 1.0 3.0 2 2 2 4 4 4 0 FOXP coiled-coil domain Ribosomal_60s PF00428.19 CCM04337.1 - 7.6 7.2 9.6 1.8 9.2 6.3 1.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein zf-C2H2_4 PF13894.6 CCM04339.1 - 0.0018 18.9 0.6 8.8 7.5 0.1 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-Di19 PF05605.12 CCM04339.1 - 0.011 15.9 1.0 0.13 12.5 0.3 2.4 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 CCM04339.1 - 0.023 15.1 4.6 0.52 10.9 0.0 3.2 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-BED PF02892.15 CCM04339.1 - 0.12 12.4 2.3 0.42 10.7 0.0 2.7 2 1 0 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.6 CCM04339.1 - 7.4 7.2 7.1 7.4 7.2 0.3 2.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.26 CCM04340.1 - 5.4e-06 26.6 0.1 0.00025 21.3 0.0 2.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM04340.1 - 9e-06 26.1 2.6 0.0047 17.7 0.0 3.4 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CCM04340.1 - 0.002 17.8 0.4 0.026 14.3 0.1 2.6 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 CCM04340.1 - 0.015 15.2 0.9 0.056 13.4 0.2 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-BED PF02892.15 CCM04340.1 - 0.041 13.9 0.5 9.1 6.4 0.1 2.3 2 0 0 2 2 2 0 BED zinc finger zf-Di19 PF05605.12 CCM04340.1 - 0.13 12.6 5.6 0.16 12.2 0.1 3.2 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 CCM04340.1 - 0.13 12.0 3.2 20 5.1 0.0 4.1 4 0 0 4 4 4 0 C2H2-type zinc-finger domain TALPID3 PF15324.6 CCM04340.1 - 6.4 4.3 4.2 7.5 4.1 4.2 1.0 1 0 0 1 1 1 0 Hedgehog signalling target zf-C2H2 PF00096.26 CCM04341.1 - 0.0011 19.3 2.6 0.021 15.2 0.1 2.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_12 PF18658.1 CCM04341.1 - 0.01 15.4 2.2 0.093 12.3 0.1 2.4 1 1 1 2 2 2 0 Zinc-finger C2H2-type FOXP-CC PF16159.5 CCM04341.1 - 0.023 15.3 9.1 0.46 11.2 0.6 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CCM04341.1 - 0.08 13.8 6.0 0.29 12.1 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger FOXP-CC PF16159.5 CCM04342.1 - 1.1e-06 29.1 3.6 0.022 15.4 0.6 3.3 2 1 1 3 3 3 3 FOXP coiled-coil domain zf-C2H2 PF00096.26 CCM04342.1 - 0.012 16.0 8.2 0.021 15.3 0.4 3.7 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_12 PF18658.1 CCM04342.1 - 0.059 13.0 2.1 1.6 8.4 0.0 3.3 2 1 2 4 4 4 0 Zinc-finger C2H2-type DUF5579 PF17742.1 CCM04342.1 - 0.27 10.8 4.9 0.094 12.3 0.6 2.4 1 1 2 3 3 3 0 Family of unknown function (DUF5579) zf-C2H2_12 PF18658.1 CCM04343.1 - 0.1 12.2 3.8 0.11 12.1 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger C2H2-type Zn_ribbon_recom PF13408.6 CCM04343.1 - 4.4 7.9 7.0 27 5.4 0.4 2.4 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain AAA_16 PF13191.6 CCM04345.1 - 0.00012 22.6 0.2 0.00056 20.3 0.1 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCM04345.1 - 0.067 13.5 0.0 0.22 11.8 0.0 1.9 1 1 1 2 2 2 0 AAA domain WD40 PF00400.32 CCM04346.1 - 1.6e-100 326.2 67.6 1.8e-08 34.9 1.4 13.6 14 0 0 14 14 13 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04346.1 - 1.9e-23 82.5 16.8 0.12 12.7 0.1 11.0 2 2 9 12 12 12 7 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCM04346.1 - 4.6e-13 49.2 2.1 6.4 7.4 0.0 11.4 12 0 0 12 12 12 1 PQQ-like domain BBS2_Mid PF14783.6 CCM04346.1 - 3.2e-09 36.8 5.4 0.96 9.5 0.0 9.6 9 2 0 9 9 9 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 CCM04346.1 - 5.9e-08 32.4 0.0 0.93 8.8 0.0 7.5 7 2 2 11 11 11 1 WD40-like domain Nucleoporin_N PF08801.11 CCM04346.1 - 4.1e-07 29.1 20.9 1.2 7.8 0.1 9.4 3 3 7 10 10 10 3 Nup133 N terminal like SLH PF00395.20 CCM04346.1 - 1.5e-06 28.1 0.0 46 4.1 0.0 8.5 11 0 0 11 11 10 0 S-layer homology domain Nup160 PF11715.8 CCM04346.1 - 3.3e-06 26.0 27.0 0.52 8.9 0.0 10.4 8 2 3 12 12 12 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCM04346.1 - 7.9e-06 25.1 0.7 4.9 6.0 0.0 6.1 3 3 3 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CCM04346.1 - 2.8e-05 22.8 22.2 0.36 9.3 0.3 6.5 2 2 5 7 7 7 5 Cytochrome D1 heme domain VID27 PF08553.10 CCM04346.1 - 3.9e-05 22.9 0.2 4.4 6.3 0.0 4.6 2 2 1 5 5 5 1 VID27 C-terminal WD40-like domain DUF4072 PF13284.6 CCM04346.1 - 0.00014 22.2 6.2 7.7 7.0 0.1 7.0 8 0 0 8 8 6 1 Domain of unknown function (DUF4072) Peptidase_S9_N PF02897.15 CCM04346.1 - 0.0002 20.3 2.6 19 3.9 0.0 6.5 3 3 3 6 6 6 0 Prolyl oligopeptidase, N-terminal beta-propeller domain PD40 PF07676.12 CCM04346.1 - 0.0016 18.3 0.0 1.1e+02 2.9 0.0 6.6 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat PQQ PF01011.21 CCM04346.1 - 0.002 18.0 0.0 49 4.1 0.0 5.6 7 0 0 7 7 7 0 PQQ enzyme repeat bacHORMA_2 PF18173.1 CCM04346.1 - 0.006 16.5 18.0 7.9 6.3 0.1 6.3 3 2 4 7 7 7 1 Bacterial HORMA domain 2 DUF4402 PF14352.6 CCM04346.1 - 0.011 16.4 1.3 34 5.1 0.0 5.3 2 2 4 6 6 6 0 Domain of unknown function (DUF4402) DUF2314 PF10077.9 CCM04346.1 - 0.055 13.5 0.0 0.53 10.4 0.0 2.7 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2314) Frtz PF11768.8 CCM04346.1 - 0.078 11.3 0.0 9.3 4.4 0.0 3.9 4 1 1 6 6 6 0 WD repeat-containing and planar cell polarity effector protein Fritz Prot_ATP_ID_OB PF16450.5 CCM04346.1 - 1.4 8.9 14.9 61 3.7 0.1 7.0 8 2 0 8 8 7 0 Proteasomal ATPase OB C-terminal domain ADH_N PF08240.12 CCM04347.1 - 1e-10 41.4 0.0 1.5e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain RNB PF00773.19 CCM04348.1 - 0.11 11.8 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 RNB domain Pkinase PF00069.25 CCM04349.1 - 2.4e-07 30.4 0.0 3.3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 CCM04350.1 - 7.1e-51 173.1 0.0 8.8e-51 172.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04350.1 - 1.1e-30 106.8 0.0 1.4e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM04350.1 - 2.6e-06 27.0 0.0 3.7e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCM04350.1 - 0.00043 19.7 0.1 0.0008 18.8 0.1 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ntox14 PF15522.6 CCM04350.1 - 0.0073 15.7 0.4 0.011 15.1 0.4 1.2 1 0 0 1 1 1 1 Novel toxin 14 Haspin_kinase PF12330.8 CCM04350.1 - 0.011 14.7 0.2 0.025 13.5 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CCM04350.1 - 0.032 14.1 0.3 0.14 12.1 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Synaptobrevin PF00957.21 CCM04351.1 - 9.4e-34 115.1 4.4 1.2e-33 114.8 4.4 1.1 1 0 0 1 1 1 1 Synaptobrevin DUF515 PF04415.12 CCM04351.1 - 0.04 12.3 0.4 0.05 12.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Shisa PF13908.6 CCM04351.1 - 0.19 12.0 0.1 0.35 11.1 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator RRM_1 PF00076.22 CCM04353.1 - 1.7e-53 178.3 0.0 5e-16 58.3 0.0 6.5 5 1 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM04353.1 - 4.5e-07 29.9 0.2 0.0053 16.9 0.0 4.0 5 0 0 5 5 5 2 RNA recognition motif RRM_Rrp7 PF17799.1 CCM04353.1 - 0.031 14.1 0.0 7.7 6.3 0.0 2.9 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Nup35_RRM_2 PF14605.6 CCM04353.1 - 0.11 12.5 0.0 19 5.4 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif NTP_transf_2 PF01909.23 CCM04354.1 - 0.00011 22.4 0.0 0.00023 21.4 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 CCM04354.1 - 0.00023 21.3 0.0 0.04 14.1 0.0 3.4 2 1 0 2 2 2 1 Cid1 family poly A polymerase ERAP1_C PF11838.8 CCM04355.1 - 1.6e-47 162.6 0.1 1.2e-45 156.4 0.0 2.1 1 1 1 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CCM04355.1 - 4.1e-09 36.3 0.0 5.9e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CCM04356.1 - 2.7e-38 132.0 0.0 8e-38 130.5 0.0 1.7 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 CCM04356.1 - 1.7e-31 109.5 0.3 2.9e-31 108.7 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain SprT-like PF10263.9 CCM04356.1 - 0.17 11.8 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 SprT-like family Paf67 PF10255.9 CCM04357.1 - 2.8e-170 566.7 0.0 3.5e-170 566.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_16 PF13432.6 CCM04357.1 - 0.0022 18.6 0.3 1.9 9.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM04357.1 - 0.02 15.0 0.0 0.13 12.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat P21-Arc PF04062.14 CCM04357.1 - 0.05 13.7 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 ARP2/3 complex ARPC3 (21 kDa) subunit SecA_PP_bind PF01043.20 CCM04357.1 - 0.094 13.4 0.0 0.24 12.1 0.0 1.6 1 0 0 1 1 1 0 SecA preprotein cross-linking domain TPR_1 PF00515.28 CCM04357.1 - 0.13 12.1 0.0 0.6 10.0 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat SNARE PF05739.19 CCM04358.1 - 4.5e-09 36.2 0.1 9.6e-09 35.1 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Sec20 PF03908.13 CCM04358.1 - 0.083 12.8 0.2 0.94 9.4 0.1 2.6 2 1 0 2 2 2 0 Sec20 HrpB7 PF09486.10 CCM04358.1 - 1.9 8.9 6.7 3.8 7.9 0.7 2.5 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) Mss4 PF04421.13 CCM04359.1 - 1.2e-14 54.2 0.0 1.9e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Mss4 protein Acetyltransf_1 PF00583.25 CCM04359.1 - 2.8e-10 40.5 0.0 4.9e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CCM04359.1 - 1.7e-07 31.6 0.0 3.4e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CCM04359.1 - 2.4e-07 30.7 0.0 4.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CCM04359.1 - 0.001 19.0 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase FR47 PF08445.10 CCM04359.1 - 0.027 14.4 0.0 0.081 12.9 0.0 1.8 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_15 PF17013.5 CCM04359.1 - 0.039 13.4 0.0 0.054 13.0 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Pkinase PF00069.25 CCM04361.1 - 4e-73 246.0 0.0 5.1e-73 245.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04361.1 - 6.8e-36 123.9 0.0 9.2e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CCM04361.1 - 3.9e-14 53.1 3.2 1e-13 51.8 3.2 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CCM04361.1 - 1.4e-05 24.2 0.0 2.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CCM04361.1 - 0.00018 21.0 0.0 0.00043 19.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CCM04361.1 - 0.015 14.9 0.0 1.8 8.1 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CCM04361.1 - 0.042 13.2 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM04361.1 - 0.063 13.2 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family GATase PF00117.28 CCM04362.1 - 1e-09 38.5 0.1 3.8e-09 36.6 0.1 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CCM04362.1 - 0.053 13.3 0.7 0.26 11.0 0.7 2.3 1 1 0 1 1 1 0 Peptidase C26 SSF PF00474.17 CCM04363.1 - 9.5e-20 70.8 34.5 1.7e-19 70.0 34.5 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2207 PF09972.9 CCM04363.1 - 0.82 8.4 0.0 0.82 8.4 0.0 4.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Pex24p PF06398.11 CCM04364.1 - 0.00015 20.9 5.3 0.00018 20.6 5.3 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin polyprenyl_synt PF00348.17 CCM04365.1 - 8.4e-92 306.8 0.0 1e-91 306.5 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DUF2732 PF10809.8 CCM04365.1 - 0.17 11.8 0.1 0.38 10.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2732) YqeY PF09424.10 CCM04366.1 - 1.1e-17 64.5 0.7 2.7e-17 63.2 0.7 1.6 1 1 0 1 1 1 1 Yqey-like protein APG5 PF04106.12 CCM04366.1 - 0.03 13.9 0.0 0.04 13.5 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg5 TipAS PF07739.13 CCM04366.1 - 0.05 14.1 2.7 0.77 10.3 0.1 2.3 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain DUF3144 PF11342.8 CCM04366.1 - 0.11 12.8 0.2 0.31 11.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3144) T3SS_basalb_I PF17001.5 CCM04366.1 - 0.15 12.7 3.0 0.2 12.3 1.0 2.0 1 1 1 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI zf-RING_UBOX PF13445.6 CCM04367.1 - 0.066 13.3 0.5 0.17 12.0 0.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 CCM04367.1 - 0.16 11.7 4.6 0.13 12.0 0.9 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 CCM04367.1 - 0.58 10.5 2.8 1.6 9.1 2.8 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CCM04367.1 - 0.62 10.4 4.6 10 6.5 4.6 2.3 1 1 0 1 1 1 0 Ring finger domain Amidohydro_3 PF07969.11 CCM04368.1 - 2.2e-81 274.7 0.1 2.6e-81 274.5 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CCM04368.1 - 1.6e-12 47.4 0.0 1e-10 41.5 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family SNF2_N PF00176.23 CCM04369.1 - 1.5e-18 66.6 0.1 2.5e-18 65.9 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCM04369.1 - 0.00028 20.9 0.0 0.0005 20.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2439 PF10382.9 CCM04369.1 - 0.062 13.6 0.0 15 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) SNF2_N PF00176.23 CCM04370.1 - 4.2e-21 75.0 0.0 6.2e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM04370.1 - 8.7e-16 58.2 0.0 1.7e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CCM04370.1 - 9.2e-05 21.7 0.0 0.00016 20.9 0.0 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DUF4577 PF15145.6 CCM04370.1 - 0.45 10.6 1.8 0.53 10.3 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) GEN1_C PF18380.1 CCM04371.1 - 4.2e-05 24.4 0.5 0.00013 22.8 0.5 2.0 1 1 0 1 1 1 1 Holliday junction resolvase Gen1 C-terminal domain Peptidase_M22 PF00814.25 CCM04372.1 - 3.8e-70 236.7 0.0 5.9e-70 236.0 0.0 1.3 1 1 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CCM04372.1 - 0.013 15.2 0.0 5.9 6.5 0.0 2.8 3 0 0 3 3 3 0 Carbamoyltransferase N-terminus FAD_binding_3 PF01494.19 CCM04373.1 - 5.4e-15 55.5 0.0 3.7e-14 52.8 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCM04373.1 - 6.9e-09 35.8 0.3 9.4e-08 32.2 0.3 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM04373.1 - 1.7e-08 34.1 0.0 4e-06 26.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM04373.1 - 1.9e-08 34.3 0.9 5.8e-06 26.1 0.6 2.4 1 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CCM04373.1 - 4.3e-08 32.3 0.0 7.7e-08 31.4 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CCM04373.1 - 6e-08 32.2 0.0 1.3e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCM04373.1 - 1.7e-06 28.5 0.1 6.5e-06 26.6 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCM04373.1 - 2.5e-05 23.5 1.1 0.0003 20.0 0.3 2.4 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CCM04373.1 - 3.4e-05 23.3 0.3 0.00097 18.5 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCM04373.1 - 0.0002 20.6 0.6 0.00045 19.4 0.2 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 CCM04373.1 - 0.00027 19.9 0.2 0.0055 15.6 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase AlaDh_PNT_C PF01262.21 CCM04373.1 - 0.00052 19.4 0.1 0.0009 18.6 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CCM04373.1 - 0.0012 18.1 0.0 0.0027 17.0 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Amino_oxidase PF01593.24 CCM04373.1 - 0.0036 16.7 0.2 0.13 11.5 0.1 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CCM04373.1 - 0.015 15.3 1.0 1.6 8.7 1.3 3.1 2 1 0 2 2 2 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 CCM04373.1 - 0.018 14.4 0.2 0.027 13.8 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase ApbA PF02558.16 CCM04373.1 - 0.056 13.1 0.1 1 9.0 0.1 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 CCM04374.1 - 1e-14 54.6 0.0 2.1e-14 53.5 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCM04374.1 - 1.6e-08 34.7 0.3 4e-08 33.4 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM04374.1 - 4.8e-08 32.6 0.0 2.5e-05 23.7 0.2 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM04374.1 - 1e-07 31.9 0.6 5.5e-06 26.2 0.7 2.4 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM04374.1 - 1.4e-06 27.7 0.0 2.3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCM04374.1 - 2.5e-06 28.0 0.0 7.8e-06 26.4 0.0 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM04374.1 - 1.9e-05 23.5 0.1 7.4e-05 21.6 0.1 1.8 1 1 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 CCM04374.1 - 0.00011 21.4 0.1 0.00095 18.3 0.1 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.14 CCM04374.1 - 0.00025 20.0 0.0 0.02 13.8 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase GIDA PF01134.22 CCM04374.1 - 0.00033 19.9 0.1 0.00058 19.1 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CCM04374.1 - 0.00067 19.0 0.1 0.0013 18.0 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCM04374.1 - 0.0012 18.2 0.0 0.003 16.9 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM04374.1 - 0.0043 16.3 0.0 0.0073 15.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 CCM04374.1 - 0.0068 16.4 0.3 0.11 12.5 0.3 2.4 1 1 0 1 1 1 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CCM04374.1 - 0.022 14.1 0.1 0.9 8.7 0.1 2.2 1 1 1 2 2 2 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CCM04374.1 - 0.029 13.7 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase TrkA_N PF02254.18 CCM04374.1 - 0.15 12.4 0.1 0.3 11.4 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Aldo_ket_red PF00248.21 CCM04375.1 - 8.4e-61 205.7 0.0 1e-60 205.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family eIF3_N PF09440.10 CCM04376.1 - 0.082 13.4 0.2 0.1 13.1 0.2 1.1 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain Con-6 PF10346.9 CCM04377.1 - 1.2e-44 150.0 16.2 1.4e-15 57.0 1.6 3.7 4 0 0 4 4 4 3 Conidiation protein 6 SpoIIIAH PF12685.7 CCM04377.1 - 0.0026 17.6 2.4 0.077 12.8 0.0 2.8 1 1 1 2 2 2 1 SpoIIIAH-like protein LytR_C PF13399.6 CCM04377.1 - 0.069 14.1 1.7 0.21 12.6 0.1 2.3 1 1 1 2 2 2 0 LytR cell envelope-related transcriptional attenuator ATP-synt_DE PF00401.20 CCM04377.1 - 0.09 13.1 5.0 3.5 8.0 0.0 3.2 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain PLN_propep PF16485.5 CCM04377.1 - 0.23 11.2 2.0 5.8 6.7 0.1 3.0 3 0 0 3 3 3 0 Protealysin propeptide GA-like PF17573.2 CCM04377.1 - 0.24 11.4 4.4 19 5.3 0.3 3.2 3 0 0 3 3 3 0 GA-like domain YhzD PF14120.6 CCM04377.1 - 0.59 10.3 4.8 23 5.2 0.1 3.4 3 1 0 3 3 3 0 YhzD-like protein adh_short PF00106.25 CCM04378.1 - 3.5e-34 118.0 0.0 4.7e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04378.1 - 4e-24 85.5 0.0 5.1e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04378.1 - 1.2e-05 25.3 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM04378.1 - 0.003 17.5 0.0 0.0041 17.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding PHO4 PF01384.20 CCM04379.1 - 0.12 11.4 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Phosphate transporter family p450 PF00067.22 CCM04380.1 - 2.9e-39 135.1 0.0 8.2e-39 133.6 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 PhoLip_ATPase_C PF16212.5 CCM04383.1 - 1.1e-77 261.2 25.6 2.2e-77 260.2 25.6 1.5 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCM04383.1 - 9.1e-26 89.3 5.4 3.8e-25 87.4 5.4 2.1 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CCM04383.1 - 9e-12 44.9 0.1 3.5e-11 43.0 0.1 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCM04383.1 - 6.1e-11 43.0 1.7 3.1e-06 27.6 0.4 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCM04383.1 - 1e-09 38.2 0.0 2.8e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CCM04383.1 - 0.031 14.0 0.1 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase RsgI_N PF12791.7 CCM04383.1 - 0.082 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Anti-sigma factor N-terminus DisA_N PF02457.16 CCM04384.1 - 0.13 11.8 0.0 0.71 9.5 0.0 1.9 2 0 0 2 2 2 0 DisA bacterial checkpoint controller nucleotide-binding PB1 PF00564.24 CCM04385.1 - 4e-12 45.9 0.0 9.5e-12 44.7 0.0 1.7 1 0 0 1 1 1 1 PB1 domain TPR_1 PF00515.28 CCM04385.1 - 4.4e-09 35.8 7.0 1.7e-05 24.4 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCM04385.1 - 1e-07 31.5 5.7 0.0015 18.5 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM04385.1 - 1.2e-06 28.2 1.3 0.00012 22.0 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM04385.1 - 1.5e-05 25.2 3.2 0.0023 18.2 0.6 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCM04385.1 - 4.5e-05 23.1 0.3 0.00015 21.4 0.3 2.0 1 0 0 1 1 1 1 TPR repeat TPR_14 PF13428.6 CCM04385.1 - 0.053 14.4 1.3 0.34 11.8 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCM04385.1 - 0.22 12.2 4.0 22 5.9 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCM04385.1 - 0.25 11.2 0.1 0.25 11.2 0.1 2.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CCM04385.1 - 0.27 11.9 6.5 0.34 11.6 2.8 3.0 2 1 1 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCM04385.1 - 0.3 11.2 2.8 0.77 9.9 0.2 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.25 CCM04386.1 - 2e-69 233.9 0.0 2.4e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04386.1 - 2.5e-29 102.3 0.0 3.6e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCM04386.1 - 0.0084 15.1 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain DUF2737 PF10930.8 CCM04386.1 - 0.018 14.6 0.1 0.052 13.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) WD40 PF00400.32 CCM04386.1 - 0.022 15.6 0.0 0.057 14.3 0.0 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat Kdo PF06293.14 CCM04386.1 - 0.047 13.0 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM04386.1 - 0.049 13.5 0.2 0.19 11.6 0.1 1.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family Aldo_ket_red PF00248.21 CCM04387.1 - 8.6e-50 169.6 0.0 5.7e-49 166.9 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Slx4 PF09494.10 CCM04387.1 - 0.084 12.8 0.4 7.3 6.6 0.0 3.0 3 0 0 3 3 3 0 Slx4 endonuclease HMG_box PF00505.19 CCM04391.1 - 3.6e-11 43.3 0.2 7.6e-11 42.3 0.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM04391.1 - 0.021 15.4 0.0 0.046 14.3 0.0 1.6 1 0 0 1 1 1 0 HMG-box domain Thioredoxin PF00085.20 CCM04393.1 - 2.6e-53 178.3 0.0 1.2e-25 89.5 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin UQ_con PF00179.26 CCM04393.1 - 1.3e-51 174.0 0.0 1.9e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ERp29 PF07749.12 CCM04393.1 - 4.3e-25 88.4 0.2 8.3e-25 87.5 0.2 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 CCM04393.1 - 5.7e-14 52.5 0.0 2.4e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 CCM04393.1 - 1.1e-13 51.2 0.0 1.6e-07 31.0 0.0 2.4 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 CCM04393.1 - 2.5e-07 30.8 0.0 0.017 15.0 0.0 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CCM04393.1 - 2.7e-06 27.4 0.0 0.1 12.8 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CCM04393.1 - 4.1e-06 27.0 0.1 0.056 13.8 0.0 4.1 3 2 2 5 5 5 1 Thioredoxin-like AhpC-TSA PF00578.21 CCM04393.1 - 4.9e-05 23.2 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family TraF PF13728.6 CCM04393.1 - 0.00046 20.1 0.0 0.056 13.3 0.0 2.3 2 0 0 2 2 2 1 F plasmid transfer operon protein Redoxin PF08534.10 CCM04393.1 - 0.0017 18.1 0.1 0.24 11.1 0.0 2.3 2 0 0 2 2 2 1 Redoxin Glutaredoxin PF00462.24 CCM04393.1 - 0.0019 18.4 0.0 0.096 12.9 0.0 2.7 2 0 0 2 2 2 1 Glutaredoxin HyaE PF07449.11 CCM04393.1 - 0.022 14.7 0.0 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE RWD PF05773.22 CCM04393.1 - 0.04 14.2 0.0 0.077 13.3 0.0 1.4 1 0 0 1 1 1 0 RWD domain Thioredoxin_9 PF14595.6 CCM04393.1 - 0.054 13.3 0.2 6.4 6.6 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin GAS PF13851.6 CCM04393.1 - 0.11 11.9 0.1 0.16 11.3 0.1 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Prok-E2_B PF14461.6 CCM04393.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B ABC_tran PF00005.27 CCM04394.1 - 8.7e-32 110.5 0.1 2.9e-17 63.4 0.0 3.2 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 CCM04394.1 - 1.1e-13 50.7 4.9 2.6e-13 49.6 4.9 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 CCM04394.1 - 3.2e-11 43.6 4.3 0.23 11.2 0.0 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM04394.1 - 7.5e-10 38.6 3.2 0.014 14.8 0.0 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 CCM04394.1 - 6.9e-07 28.8 3.2 6.9e-07 28.8 3.2 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_16 PF13191.6 CCM04394.1 - 1.4e-05 25.5 0.0 0.21 12.0 0.0 2.7 2 2 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 CCM04394.1 - 1.5e-05 25.4 0.0 0.12 12.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CCM04394.1 - 3.7e-05 23.7 0.0 0.31 10.9 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CCM04394.1 - 9.4e-05 22.7 0.0 0.042 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CCM04394.1 - 0.00017 21.6 0.5 0.062 13.2 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 CCM04394.1 - 0.00018 21.3 0.1 0.24 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 CCM04394.1 - 0.00019 21.6 0.1 0.11 12.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain Fer4_6 PF12837.7 CCM04394.1 - 0.00055 19.9 2.2 0.00055 19.9 2.2 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.6 CCM04394.1 - 0.0012 18.5 0.7 1.3 8.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RNA_helicase PF00910.22 CCM04394.1 - 0.0016 18.8 0.0 1.9 8.9 0.0 2.8 2 0 0 2 2 2 1 RNA helicase SRP54 PF00448.22 CCM04394.1 - 0.0018 17.9 1.4 0.48 10.0 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Rad17 PF03215.15 CCM04394.1 - 0.0021 18.0 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_24 PF13479.6 CCM04394.1 - 0.0029 17.4 0.1 0.7 9.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 CCM04394.1 - 0.0029 17.7 14.6 0.0043 17.1 1.1 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CCM04394.1 - 0.004 17.2 0.6 0.004 17.2 0.6 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.6 CCM04394.1 - 0.0054 16.8 11.8 0.01 15.9 11.8 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CCM04394.1 - 0.0061 17.1 1.7 0.0061 17.1 1.7 2.3 1 1 2 3 3 3 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CCM04394.1 - 0.0062 16.7 11.7 0.013 15.7 11.7 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain NB-ARC PF00931.22 CCM04394.1 - 0.0065 15.7 0.0 0.21 10.8 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_7 PF12775.7 CCM04394.1 - 0.0065 16.0 0.1 0.2 11.1 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region SbcCD_C PF13558.6 CCM04394.1 - 0.0067 16.6 0.0 4.7 7.5 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 CCM04394.1 - 0.0077 16.8 0.6 3.1 8.4 0.1 3.0 2 1 1 3 3 3 1 AAA domain TsaE PF02367.17 CCM04394.1 - 0.01 15.8 0.2 0.3 11.1 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CCM04394.1 - 0.012 15.9 0.3 2.6 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CCM04394.1 - 0.012 15.8 0.6 0.076 13.2 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_13 PF13166.6 CCM04394.1 - 0.018 13.7 0.1 0.24 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CCM04394.1 - 0.019 15.0 1.1 0.76 9.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.17 CCM04394.1 - 0.022 14.4 0.1 3.8 7.2 0.0 3.1 2 1 1 3 3 3 0 Thymidylate kinase Fer4_16 PF13484.6 CCM04394.1 - 0.023 15.6 0.3 0.023 15.6 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 CCM04394.1 - 0.031 14.8 0.1 0.031 14.8 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain AAA_30 PF13604.6 CCM04394.1 - 0.033 13.9 0.1 3.6 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain VirE PF05272.11 CCM04394.1 - 0.057 13.1 0.0 5.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E AAA_14 PF13173.6 CCM04394.1 - 0.06 13.4 1.6 8 6.5 0.0 3.4 2 2 1 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 CCM04394.1 - 0.085 12.9 0.6 11 6.1 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase Fer4_8 PF13183.6 CCM04394.1 - 0.12 12.8 0.1 0.12 12.8 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain CLP1_P PF16575.5 CCM04394.1 - 0.18 11.6 0.2 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_23 PF13476.6 CCM04394.1 - 0.23 11.9 9.5 0.35 11.3 0.2 2.9 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCM04394.1 - 0.26 11.2 1.7 35 4.2 0.0 3.4 4 0 0 4 4 3 0 NTPase Fer4_4 PF12800.7 CCM04394.1 - 1.7 9.3 14.6 0.41 11.3 3.0 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain PIG-S PF10510.9 CCM04395.1 - 1.8e-122 409.8 1.9 2.6e-122 409.3 1.9 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein BRAP2 PF07576.12 CCM04395.1 - 0.15 12.3 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 BRCA1-associated protein 2 Myb_DNA-binding PF00249.31 CCM04396.1 - 1.7e-14 53.8 0.0 2.3e-06 27.7 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCM04396.1 - 1.4e-07 31.6 0.0 0.014 15.6 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CCM04396.1 - 7.3e-07 29.0 0.0 0.0002 21.2 0.0 2.5 2 0 0 2 2 2 2 Myb DNA-binding like Rotamase_3 PF13616.6 CCM04397.1 - 1.4e-17 64.3 0.1 2e-17 63.8 0.1 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 CCM04397.1 - 1.4e-14 54.8 0.2 2.3e-14 54.1 0.2 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CCM04397.1 - 0.0056 17.5 0.1 0.0078 17.0 0.1 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Elongin_A PF06881.11 CCM04400.1 - 2.1e-12 47.5 0.0 3.6e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Gti1_Pac2 PF09729.9 CCM04401.1 - 1.3e-30 106.8 0.6 1.6e-28 100.1 1.3 2.1 1 1 1 2 2 2 2 Gti1/Pac2 family cwf18 PF08315.12 CCM04402.1 - 1.2e-34 119.9 9.3 1.7e-34 119.3 9.3 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor SIR4_SID PF16991.5 CCM04402.1 - 0.055 13.5 0.2 0.073 13.1 0.2 1.2 1 0 0 1 1 1 0 Sir4 SID domain GTP_EFTU PF00009.27 CCM04403.1 - 1.5e-46 158.4 0.1 2.4e-46 157.8 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CCM04403.1 - 1.5e-42 144.1 0.1 1.5e-42 144.1 0.1 1.7 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CCM04403.1 - 3e-15 56.0 0.0 6.5e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 CCM04403.1 - 1.2e-06 28.5 0.1 4.8e-06 26.6 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CCM04403.1 - 1.2e-05 25.3 0.0 3.7e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 CCM04403.1 - 1.8e-05 24.4 0.0 4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Ras family RF3_C PF16658.5 CCM04403.1 - 0.00043 20.1 0.0 0.00093 19.0 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 CCM04403.1 - 0.0018 18.7 0.0 0.0045 17.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 FeoB_N PF02421.18 CCM04403.1 - 0.0059 16.1 0.0 0.023 14.2 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCM04403.1 - 0.024 14.6 0.2 0.26 11.2 0.0 2.2 1 1 1 2 2 2 0 RsgA GTPase SRPRB PF09439.10 CCM04403.1 - 0.039 13.4 0.0 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 CCM04403.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Thioredoxin PF00085.20 CCM04404.1 - 1.5e-08 34.6 0.0 1.5e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCM04404.1 - 1.7e-06 28.5 0.0 1.7e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain HyaE PF07449.11 CCM04404.1 - 0.038 14.0 0.0 0.041 13.8 0.0 1.1 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE A_deaminase PF00962.22 CCM04405.1 - 3.7e-30 105.4 0.0 1e-27 97.4 0.0 2.6 2 1 0 2 2 2 2 Adenosine/AMP deaminase KASH_CCD PF14662.6 CCM04406.1 - 0.0008 19.3 5.5 0.0008 19.3 5.5 2.6 3 1 0 3 3 3 2 Coiled-coil region of CCDC155 or KASH FAM76 PF16046.5 CCM04406.1 - 0.012 15.0 6.1 0.19 11.1 1.2 2.3 2 0 0 2 2 2 0 FAM76 protein DUF4407 PF14362.6 CCM04406.1 - 0.049 13.0 9.7 0.11 11.8 9.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Csm1 PF12539.8 CCM04406.1 - 0.098 13.3 1.8 0.14 12.8 0.3 2.1 2 1 0 2 2 2 0 Chromosome segregation protein Csm1/Pcs1 Takusan PF04822.13 CCM04406.1 - 0.13 12.1 5.1 0.25 11.3 3.5 2.4 2 0 0 2 2 2 0 Takusan Baculo_PEP_C PF04513.12 CCM04406.1 - 0.14 12.2 2.4 0.17 11.9 0.5 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_L PF02601.15 CCM04406.1 - 0.2 11.2 10.6 0.34 10.4 10.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lectin_N PF03954.14 CCM04406.1 - 1.1 9.0 4.6 5.4 6.8 4.6 2.3 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Fungal_TACC PF12709.7 CCM04406.1 - 3.4 8.2 10.3 0.44 11.0 1.0 3.3 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Asparaginase PF00710.20 CCM04407.1 - 8.6e-53 178.7 0.0 5.5e-52 176.1 0.0 2.1 1 1 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CCM04407.1 - 1.3e-29 102.8 0.0 2.2e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 CCM04407.1 - 1e-10 42.0 0.3 6.3e-10 39.5 0.3 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCM04407.1 - 1e-08 35.5 1.1 7.2e-06 26.5 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM04407.1 - 1.8e-07 30.9 1.4 0.058 14.0 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 CCM04407.1 - 4.6e-07 30.0 1.7 0.011 16.1 0.3 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CCM04407.1 - 0.0022 18.3 2.6 0.16 12.3 0.3 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Trp_syntA PF00290.20 CCM04408.1 - 3.4e-85 285.0 0.1 4.8e-85 284.5 0.1 1.1 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 CCM04408.1 - 9.3e-47 159.8 0.3 1.4e-46 159.2 0.3 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme His_biosynth PF00977.21 CCM04408.1 - 0.00027 20.5 0.0 0.00082 18.9 0.0 1.8 1 0 0 1 1 1 1 Histidine biosynthesis protein PA PF02225.22 CCM04408.1 - 0.024 14.7 0.0 6.4 6.9 0.0 2.7 2 0 0 2 2 2 0 PA domain DUF812 PF05667.11 CCM04410.1 - 0.00053 19.0 4.1 0.0011 18.0 4.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF812) Muted PF14942.6 CCM04410.1 - 0.0031 17.9 1.0 0.0064 16.8 1.0 1.5 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein Spc7 PF08317.11 CCM04410.1 - 0.021 13.7 5.9 0.029 13.3 5.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Bcr-Abl_Oligo PF09036.10 CCM04410.1 - 0.031 14.3 0.3 0.031 14.3 0.3 1.9 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain GrpE PF01025.19 CCM04410.1 - 0.074 12.7 2.1 0.14 11.8 2.1 1.5 1 0 0 1 1 1 0 GrpE DUF4140 PF13600.6 CCM04410.1 - 0.092 13.2 0.5 6.2 7.3 0.9 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TPR_MLP1_2 PF07926.12 CCM04410.1 - 0.36 10.9 7.2 0.22 11.6 4.1 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-H PF05837.12 CCM04410.1 - 0.57 10.6 7.2 0.46 10.9 1.2 2.3 1 1 0 2 2 2 0 Centromere protein H (CENP-H) ADIP PF11559.8 CCM04410.1 - 0.84 9.7 10.8 0.24 11.5 3.3 2.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding TEX13 PF15186.6 CCM04410.1 - 1.1 9.0 6.3 1.3 8.7 2.0 2.1 1 1 2 3 3 3 0 Testis-expressed sequence 13 protein family DUF883 PF05957.13 CCM04410.1 - 3.9 8.2 6.5 7.1 7.3 2.3 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Brix PF04427.18 CCM04411.1 - 2.4e-37 128.9 0.1 3.2e-37 128.5 0.1 1.2 1 0 0 1 1 1 1 Brix domain IF-2B PF01008.17 CCM04412.1 - 5.3e-64 216.1 0.0 6.4e-64 215.9 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Cyt_c_ox_IV PF12270.8 CCM04412.1 - 0.037 14.2 0.0 0.12 12.5 0.1 1.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV RNA_pol_L_2 PF13656.6 CCM04412.1 - 0.066 13.0 0.1 8.6 6.2 0.0 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-C3HC4_3 PF13920.6 CCM04413.1 - 0.00012 21.9 3.5 0.00012 21.9 3.5 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM04413.1 - 0.00078 19.3 4.7 0.00078 19.3 4.7 2.0 2 0 0 2 2 1 1 zinc-RING finger domain KxDL PF10241.9 CCM04413.1 - 0.0045 17.2 1.6 1.3 9.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein DUF3584 PF12128.8 CCM04413.1 - 0.0046 14.5 6.8 0.0057 14.3 6.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF4472 PF14739.6 CCM04413.1 - 0.0053 17.5 8.9 0.49 11.2 5.5 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4472) Prok-RING_4 PF14447.6 CCM04413.1 - 0.015 15.2 2.2 0.015 15.2 2.2 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 ZapB PF06005.12 CCM04413.1 - 0.015 15.7 14.8 0.069 13.6 7.2 2.8 1 1 1 2 2 2 0 Cell division protein ZapB TRCF PF03461.15 CCM04413.1 - 0.023 15.1 0.4 0.046 14.1 0.2 1.6 1 1 0 1 1 1 0 TRCF domain FAM184 PF15665.5 CCM04413.1 - 0.052 13.3 5.4 0.093 12.5 5.4 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B zf-RING_UBOX PF13445.6 CCM04413.1 - 0.077 13.0 4.5 0.57 10.3 4.9 2.2 1 1 1 2 2 2 0 RING-type zinc-finger Jnk-SapK_ap_N PF09744.9 CCM04413.1 - 0.11 12.7 12.8 0.24 11.6 12.5 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 CCM04413.1 - 0.16 11.5 5.4 0.21 11.1 5.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.11 CCM04413.1 - 0.21 10.4 11.1 0.095 11.6 6.7 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein NPV_P10 PF05531.12 CCM04413.1 - 0.23 12.0 1.6 16 6.1 0.1 2.6 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein XRN_M PF17846.1 CCM04413.1 - 0.3 10.0 2.1 0.4 9.6 2.1 1.1 1 0 0 1 1 1 0 Xrn1 helical domain zf-RING_2 PF13639.6 CCM04413.1 - 0.47 10.8 7.5 0.075 13.4 3.1 2.0 2 0 0 2 2 2 0 Ring finger domain zf-RING_4 PF14570.6 CCM04413.1 - 0.5 10.2 3.8 1.6 8.6 3.8 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4407 PF14362.6 CCM04413.1 - 0.53 9.6 8.1 0.67 9.2 7.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C3HC4_4 PF15227.6 CCM04413.1 - 0.58 10.4 4.2 1.9 8.7 4.2 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Syntaxin_2 PF14523.6 CCM04413.1 - 0.64 10.4 5.8 3.8 7.9 2.8 2.2 1 1 1 2 2 2 0 Syntaxin-like protein OmpH PF03938.14 CCM04413.1 - 0.67 10.3 8.2 0.62 10.4 7.0 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) TPR_MLP1_2 PF07926.12 CCM04413.1 - 0.93 9.6 15.7 0.58 10.2 3.2 3.2 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Sigma70_ner PF04546.13 CCM04413.1 - 1.3 8.8 7.2 3.3 7.6 3.7 2.1 1 1 1 2 2 2 0 Sigma-70, non-essential region zf-C3HC4 PF00097.25 CCM04413.1 - 1.3 8.9 9.4 0.1 12.5 4.1 2.0 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) DUF725 PF05267.12 CCM04413.1 - 2 8.4 7.6 0.75 9.8 1.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF725) DUF4201 PF13870.6 CCM04413.1 - 2.4 7.8 12.7 5.6 6.7 6.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) zf-C3HC4_2 PF13923.6 CCM04413.1 - 3.2 7.7 8.3 0.37 10.7 3.4 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FUSC PF04632.12 CCM04413.1 - 4.6 5.6 12.3 4.5 5.7 0.3 1.6 1 1 1 2 2 2 0 Fusaric acid resistance protein family Atg14 PF10186.9 CCM04413.1 - 5.2 6.0 13.3 9.9 5.1 13.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RecR PF02132.15 CCM04413.1 - 9.6 5.9 10.7 1.5 8.4 1.1 3.7 3 1 1 4 4 4 0 RecR protein KH_1 PF00013.29 CCM04414.1 - 1.1e-42 143.6 8.2 5.7e-15 54.9 0.4 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CCM04414.1 - 3.2e-15 55.7 5.9 2.4e-05 24.1 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CCM04414.1 - 4.1e-05 23.4 2.0 0.71 9.8 0.0 3.4 3 0 0 3 3 3 2 KH domain KH_5 PF13184.6 CCM04414.1 - 0.0015 18.6 5.2 0.52 10.4 0.1 3.5 3 0 0 3 3 3 2 NusA-like KH domain CPDase PF07823.11 CCM04416.1 - 1.9e-12 47.3 0.0 1e-10 41.6 0.0 2.4 1 1 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 CCM04416.1 - 1.4e-07 31.6 0.0 2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 CCM04416.1 - 0.00011 22.3 0.0 0.31 11.3 0.0 2.2 2 0 0 2 2 2 2 LigT like Phosphoesterase DUF1776 PF08643.10 CCM04418.1 - 6.5e-12 45.4 0.0 8.9e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) RdRP PF05183.12 CCM04418.1 - 0.038 12.6 0.1 0.054 12.1 0.1 1.1 1 0 0 1 1 1 0 RNA dependent RNA polymerase Lectin_like PF18560.1 CCM04418.1 - 0.11 12.7 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Lectin like domain DUF883 PF05957.13 CCM04418.1 - 0.11 13.1 0.2 0.41 11.3 0.1 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) PRIMA1 PF16101.5 CCM04418.1 - 1.9 8.5 6.7 4.9 7.2 6.7 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ATP-synt_ab PF00006.25 CCM04419.1 - 1.7e-63 214.2 0.0 2.7e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CCM04419.1 - 2.3e-21 76.1 1.0 5.9e-21 74.8 1.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain NB-ARC PF00931.22 CCM04419.1 - 0.0055 15.9 0.7 0.012 14.9 0.1 1.7 2 0 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 CCM04419.1 - 0.028 14.3 0.1 0.06 13.2 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 CCM04419.1 - 0.029 14.8 0.0 0.4 11.1 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CCM04419.1 - 0.036 14.0 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 CCM04419.1 - 0.055 13.8 0.9 0.16 12.3 0.2 2.2 2 1 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 CCM04419.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ATPase PF06745.13 CCM04419.1 - 0.08 12.3 0.1 0.14 11.4 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.6 CCM04419.1 - 0.094 13.0 0.7 0.31 11.4 0.1 2.0 2 0 0 2 2 2 0 AAA domain Med2 PF11214.8 CCM04419.1 - 0.12 12.5 0.0 0.32 11.2 0.0 1.7 2 0 0 2 2 1 0 Mediator complex subunit 2 GATase_6 PF13522.6 CCM04420.1 - 6.7e-12 45.8 0.0 1.3e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 CCM04420.1 - 6.5e-10 38.8 0.2 1.1e-09 38.0 0.2 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_7 PF13537.6 CCM04420.1 - 8.8e-09 35.3 0.0 1.4e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CCM04420.1 - 1.3e-05 24.3 0.0 3.5e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Na_Ca_ex PF01699.24 CCM04421.1 - 2.3e-36 125.0 36.5 1.4e-21 77.0 13.4 2.9 2 1 1 3 3 3 2 Sodium/calcium exchanger protein Na_Ca_ex PF01699.24 CCM04422.1 - 2.2e-24 86.2 28.0 6.5e-13 48.9 5.0 2.6 3 1 0 3 3 3 2 Sodium/calcium exchanger protein Gtr1_RagA PF04670.12 CCM04423.1 - 1.5e-82 276.4 0.0 2.1e-82 275.9 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 CCM04423.1 - 1.6e-07 31.1 0.0 2.6e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM04423.1 - 1.9e-07 31.3 0.0 4.3e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM04423.1 - 2.2e-05 24.0 0.0 3.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCM04423.1 - 2.3e-05 24.5 0.0 4.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CCM04423.1 - 0.031 14.0 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation APG6_N PF17675.1 CCM04423.1 - 0.067 13.7 0.0 2.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region AAA_24 PF13479.6 CCM04423.1 - 0.1 12.3 0.1 0.32 10.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CCM04423.1 - 0.12 12.2 0.5 3.8 7.4 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase Svf1 PF08622.10 CCM04423.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Svf1-like N-terminal lipocalin domain DMRL_synthase PF00885.19 CCM04424.1 - 2.2e-57 192.9 0.0 2.8e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase ATP_bind_3 PF01171.20 CCM04425.1 - 8.6e-29 100.6 0.0 1.4e-28 99.9 0.0 1.3 1 0 0 1 1 1 1 PP-loop family KfrA_N PF11740.8 CCM04425.1 - 0.01 16.5 1.5 0.024 15.3 1.5 1.6 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term YTH PF04146.15 CCM04426.1 - 4.8e-40 137.2 0.4 1.3e-39 135.8 0.0 2.0 2 0 0 2 2 2 1 YT521-B-like domain WD40 PF00400.32 CCM04428.1 - 2.1e-55 183.4 14.6 1e-08 35.6 0.0 8.2 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04428.1 - 1.1e-20 73.8 0.2 1.7e-07 31.4 0.0 5.8 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCM04428.1 - 3.1e-08 32.7 5.2 0.064 11.9 0.1 5.1 3 2 1 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CCM04428.1 - 0.0001 21.2 0.4 0.73 8.5 0.3 3.8 1 1 3 4 4 4 2 Nup133 N terminal like eIF2A PF08662.11 CCM04428.1 - 0.0016 18.3 0.0 0.34 10.8 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DUF1652 PF07865.11 CCM04428.1 - 0.013 15.3 0.0 19 5.2 0.0 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF1652) Ge1_WD40 PF16529.5 CCM04428.1 - 0.031 13.2 0.2 1.6 7.6 0.0 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ADIP PF11559.8 CCM04428.1 - 0.041 14.0 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding bZIP_2 PF07716.15 CCM04428.1 - 0.1 12.7 0.6 0.2 11.8 0.6 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Pox_A_type_inc PF04508.12 CCM04428.1 - 0.23 11.4 0.2 0.53 10.2 0.2 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DASH_Dad3 PF08656.10 CCM04430.1 - 8.2e-23 80.3 0.2 1e-22 80.0 0.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 WD40 PF00400.32 CCM04431.1 - 1.3e-10 41.6 9.7 0.013 16.3 0.0 5.9 4 1 1 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04431.1 - 3.6e-09 36.8 0.1 0.0032 17.7 0.0 4.2 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 CCM04431.1 - 0.0033 16.2 1.6 0.093 11.5 0.3 2.7 2 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region eIF2A PF08662.11 CCM04431.1 - 0.0077 16.1 0.1 0.31 10.9 0.0 2.7 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Acetyltransf_7 PF13508.7 CCM04432.1 - 2.3e-09 37.6 0.0 4.2e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM04432.1 - 1.3e-08 35.1 0.0 2.9e-08 34.0 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM04432.1 - 2.4e-08 34.0 0.0 8.6e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CCM04432.1 - 0.0026 17.7 0.1 0.01 15.8 0.0 2.0 2 1 0 2 2 2 1 ESCO1/2 acetyl-transferase Acetyltransf_CG PF14542.6 CCM04432.1 - 0.0072 16.4 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 CCM04432.1 - 0.019 15.6 0.0 0.035 14.8 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM04432.1 - 0.064 13.2 0.0 0.22 11.5 0.0 1.8 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_9 PF13527.7 CCM04432.1 - 0.072 13.2 0.0 0.38 10.8 0.0 2.1 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CCM04432.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Golgin_A5 PF09787.9 CCM04433.1 - 0.00087 18.9 6.5 0.00087 18.9 6.5 1.6 1 1 1 2 2 2 1 Golgin subfamily A member 5 Lebercilin PF15619.6 CCM04433.1 - 0.0013 18.5 13.7 0.0074 16.0 10.0 2.0 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.12 CCM04433.1 - 0.0055 16.8 10.7 0.01 15.9 4.6 2.8 2 1 1 3 3 3 2 TPR/MLP1/MLP2-like protein Filament PF00038.21 CCM04433.1 - 0.059 12.9 8.8 0.066 12.8 4.9 1.9 2 0 0 2 2 2 0 Intermediate filament protein APG6_N PF17675.1 CCM04433.1 - 0.077 13.5 9.6 0.19 12.2 9.6 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region COG2 PF06148.11 CCM04433.1 - 0.1 12.7 4.4 0.13 12.3 2.3 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CorA PF01544.18 CCM04433.1 - 0.11 11.8 2.5 0.17 11.2 2.5 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF5082 PF16888.5 CCM04433.1 - 0.11 12.8 6.8 0.11 12.8 3.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) CENP-F_leu_zip PF10473.9 CCM04433.1 - 0.15 12.1 12.4 0.28 11.2 6.5 2.7 2 2 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 CCM04433.1 - 0.15 12.1 6.0 0.88 9.6 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CSN5_C PF18323.1 CCM04433.1 - 0.17 12.8 1.4 0.4 11.6 1.0 1.8 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain DUF1515 PF07439.11 CCM04433.1 - 0.23 11.5 2.1 0.59 10.2 2.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF724 PF05266.14 CCM04433.1 - 0.28 11.0 5.3 0.16 11.8 2.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Snapin_Pallidin PF14712.6 CCM04433.1 - 0.37 11.2 5.3 2.3 8.7 2.2 2.9 2 1 0 2 2 2 0 Snapin/Pallidin Spc7 PF08317.11 CCM04433.1 - 0.41 9.5 7.4 0.33 9.8 3.7 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein FOXP-CC PF16159.5 CCM04433.1 - 0.49 11.1 3.9 1.4 9.6 0.5 2.8 2 1 0 3 3 3 0 FOXP coiled-coil domain Spc24 PF08286.11 CCM04433.1 - 0.49 10.7 6.7 11 6.3 4.8 2.8 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 DivIC PF04977.15 CCM04433.1 - 0.65 9.8 7.5 1.8 8.4 4.5 2.6 2 1 0 2 2 2 0 Septum formation initiator DUF4407 PF14362.6 CCM04433.1 - 1.3 8.3 6.6 1.8 7.8 6.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 CCM04433.1 - 1.4 7.9 10.6 1.6 7.8 10.6 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 CCM04433.1 - 1.9 9.2 5.7 1.5 9.5 2.4 2.0 2 0 0 2 2 2 0 Initiation control protein YabA DUF4140 PF13600.6 CCM04433.1 - 2.4 8.6 10.2 11 6.6 0.1 2.9 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) Uso1_p115_C PF04871.13 CCM04433.1 - 2.7 8.4 11.7 6.3 7.2 6.9 2.3 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Rho_Binding PF08912.11 CCM04433.1 - 2.9 8.8 8.6 2.8 8.8 2.9 2.7 2 1 1 3 3 3 0 Rho Binding Dzip-like_N PF13815.6 CCM04433.1 - 4.3 7.3 7.7 17 5.4 3.8 2.7 1 1 2 3 3 3 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal CENP-H PF05837.12 CCM04433.1 - 6 7.3 11.3 1.6 9.2 7.7 1.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) adh_short PF00106.25 CCM04434.1 - 4.7e-30 104.5 0.1 8.7e-30 103.6 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04434.1 - 2.1e-25 89.6 0.1 3.5e-25 88.9 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04434.1 - 2.1e-10 40.8 0.0 6.7e-10 39.2 0.0 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CCM04434.1 - 0.00026 20.3 0.0 0.00039 19.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCM04434.1 - 0.012 15.1 0.1 0.034 13.6 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family CENP-F_leu_zip PF10473.9 CCM04435.1 - 0.12 12.5 0.4 0.17 11.9 0.4 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prominin PF05478.11 CCM04435.1 - 0.36 8.7 1.6 0.45 8.4 1.6 1.0 1 0 0 1 1 1 0 Prominin DUF5304 PF17230.2 CCM04435.1 - 1.9 8.7 13.8 15 5.8 10.1 2.3 1 1 0 2 2 2 0 Family of unknown function (DUF5304) SOAR PF16533.5 CCM04435.1 - 1.9 8.5 5.5 5.1 7.1 0.7 2.3 1 1 1 2 2 2 0 STIM1 Orai1-activating region Glyco_transf_8 PF01501.20 CCM04436.1 - 4.1e-22 79.0 0.0 8.7e-22 77.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 ABC1 PF03109.16 CCM04437.1 - 4.5e-21 75.2 0.0 2.7e-12 46.9 0.0 2.4 2 0 0 2 2 2 2 ABC1 family Oxidored_FMN PF00724.20 CCM04438.1 - 3.6e-34 118.5 0.0 4.7e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ComA PF02679.15 CCM04438.1 - 0.0022 17.5 0.0 0.4 10.1 0.0 2.1 2 0 0 2 2 2 2 (2R)-phospho-3-sulfolactate synthase (ComA) Oxidored_FMN PF00724.20 CCM04439.1 - 6.3e-23 81.6 0.0 7.4e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Fructosamin_kin PF03881.14 CCM04440.1 - 4.4e-62 209.9 0.0 5.1e-62 209.7 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CCM04440.1 - 8.3e-05 22.6 0.0 0.00021 21.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family RNA_pol_Rpb2_6 PF00562.28 CCM04441.1 - 2.5e-126 421.9 0.1 3.6e-126 421.4 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CCM04441.1 - 1.8e-68 230.0 0.0 2.6e-68 229.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CCM04441.1 - 4.7e-47 160.1 0.3 9.4e-47 159.1 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CCM04441.1 - 9.8e-33 112.4 0.1 2.2e-32 111.3 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 CCM04441.1 - 3e-26 91.5 0.4 8.5e-26 90.0 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 CCM04441.1 - 3.8e-25 87.8 0.2 9.3e-25 86.6 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 CCM04441.1 - 5.3e-22 78.1 0.2 1.7e-21 76.5 0.2 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Lung_7-TM_R PF06814.13 CCM04443.1 - 1.4e-60 205.0 14.8 1.7e-60 204.8 14.8 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SafA PF17073.5 CCM04443.1 - 0.11 12.5 0.1 0.3 11.1 0.1 1.8 1 0 0 1 1 1 0 Two-component-system connector protein Oxidored_q2 PF00420.24 CCM04443.1 - 0.28 10.9 12.4 1.1e+02 2.5 12.4 2.6 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L MRAP PF15183.6 CCM04443.1 - 5.1 7.1 7.6 1 9.4 1.0 2.7 1 1 1 2 2 2 0 Melanocortin-2 receptor accessory protein family PX PF00787.24 CCM04444.1 - 1.2e-18 67.1 0.2 5.7e-18 65.0 0.4 2.0 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 CCM04444.1 - 0.0015 18.2 2.4 0.0033 17.0 0.9 2.3 2 1 0 3 3 3 1 Vps5 C terminal like BAR_3 PF16746.5 CCM04444.1 - 0.0018 18.1 0.1 0.0069 16.1 0.0 2.0 2 0 0 2 2 2 1 BAR domain of APPL family HORMA PF02301.18 CCM04445.1 - 2.4e-08 33.8 0.1 3.7e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 HORMA domain Fungal_trans PF04082.18 CCM04446.1 - 3.8e-31 108.1 1.7 6.9e-31 107.3 1.7 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM04446.1 - 5.6e-06 26.4 10.9 9.4e-06 25.7 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RseA_C PF03873.13 CCM04446.1 - 0.14 12.4 0.4 0.38 11.0 0.4 1.7 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain CWC25 PF12542.8 CCM04447.1 - 3.3e-25 89.0 1.0 3.3e-25 89.0 1.0 4.0 3 1 1 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 CCM04447.1 - 9.6e-14 51.3 12.5 9.6e-14 51.3 12.5 4.4 3 1 1 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR TIP41 PF04176.13 CCM04447.1 - 0.57 9.6 4.4 0.26 10.8 2.1 1.7 1 1 1 2 2 2 0 TIP41-like family Ion_trans PF00520.31 CCM04448.1 - 0.00034 19.9 4.9 0.00043 19.6 4.9 1.1 1 0 0 1 1 1 1 Ion transport protein MFS_3 PF05977.13 CCM04448.1 - 0.17 10.2 3.2 0.23 9.8 3.2 1.1 1 0 0 1 1 1 0 Transmembrane secretion effector SUR7 PF06687.12 CCM04448.1 - 1.7 8.2 8.1 0.83 9.2 0.7 2.1 1 1 1 2 2 2 0 SUR7/PalI family ANTH PF07651.16 CCM04450.1 - 5.2e-56 189.7 0.0 5.2e-56 189.7 0.0 3.2 4 0 0 4 4 4 1 ANTH domain I_LWEQ PF01608.17 CCM04450.1 - 1.4e-54 184.5 10.4 1.4e-54 184.5 10.4 5.4 5 1 1 6 6 6 1 I/LWEQ domain TcdB_N PF12918.7 CCM04450.1 - 0.0021 18.3 0.5 0.019 15.3 0.0 2.8 2 0 0 2 2 2 1 TcdB toxin N-terminal helical domain FAA_hydro_N_2 PF18288.1 CCM04450.1 - 0.0055 17.1 1.7 0.05 14.0 0.5 3.3 1 1 1 2 2 2 1 Fumarylacetoacetase N-terminal domain 2 FAD_binding_4 PF01565.23 CCM04450.1 - 0.11 12.3 1.5 4.6 7.0 0.1 3.3 3 1 0 4 4 4 0 FAD binding domain YjcQ PF09639.10 CCM04450.1 - 3.5 7.9 6.3 0.84 9.9 0.1 2.8 3 0 0 3 3 3 0 YjcQ protein SURF1 PF02104.15 CCM04451.1 - 1.1e-38 133.3 0.0 3e-38 131.8 0.0 1.7 1 0 0 1 1 1 1 SURF1 family Myb_DNA-bind_7 PF15963.5 CCM04453.1 - 1.4e-19 69.7 0.2 4.4e-19 68.2 0.2 1.9 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 CCM04453.1 - 1.1e-08 35.1 0.0 2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCM04453.1 - 0.0035 17.6 0.4 0.01 16.0 0.1 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Rad51 PF08423.11 CCM04454.1 - 4.1e-103 344.1 0.3 6.2e-103 343.5 0.0 1.4 2 0 0 2 2 2 1 Rad51 RecA PF00154.21 CCM04454.1 - 1e-12 48.1 0.4 1.4e-12 47.6 0.4 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 CCM04454.1 - 3e-07 30.2 0.0 6.8e-07 29.1 0.0 1.5 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 CCM04454.1 - 2e-05 24.1 0.6 2e-05 24.1 0.6 2.0 2 1 0 2 2 2 1 KaiC AAA_24 PF13479.6 CCM04454.1 - 0.0013 18.5 0.0 0.0037 17.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain HHH_5 PF14520.6 CCM04454.1 - 0.015 15.8 0.3 0.038 14.6 0.1 1.8 2 0 0 2 2 1 0 Helix-hairpin-helix domain AAA PF00004.29 CCM04454.1 - 0.025 15.0 0.2 0.16 12.4 0.2 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_pol_A_CTD PF03118.15 CCM04454.1 - 0.035 13.9 0.2 0.078 12.8 0.2 1.6 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain DnaB_C PF03796.15 CCM04454.1 - 0.039 13.3 1.1 0.14 11.4 0.2 2.2 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain DUF1565 PF07602.11 CCM04454.1 - 0.06 12.7 0.1 0.092 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) PAXNEB PF05625.11 CCM04454.1 - 0.078 12.1 0.1 0.16 11.1 0.0 1.5 2 0 0 2 2 2 0 PAXNEB protein HHH_3 PF12836.7 CCM04454.1 - 0.12 12.6 0.1 0.58 10.5 0.1 2.2 1 1 0 1 1 1 0 Helix-hairpin-helix motif EthD PF07110.11 CCM04455.1 - 2.1e-06 28.8 0.1 0.048 14.8 0.0 2.6 2 1 0 2 2 2 2 EthD domain DUF4286 PF14114.6 CCM04455.1 - 0.00016 22.1 0.1 0.64 10.6 0.0 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4286) ABM PF03992.16 CCM04455.1 - 0.0031 17.6 0.0 0.01 15.9 0.0 1.9 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Ribonuclease_T2 PF00445.18 CCM04456.1 - 2.8e-39 135.2 0.1 3.8e-39 134.8 0.1 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family DREV PF05219.12 CCM04457.1 - 0.043 12.9 0.0 0.063 12.4 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Peptidase_M16 PF00675.20 CCM04458.1 - 7.2e-39 133.1 0.0 1.1e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CCM04458.1 - 4.4e-35 121.3 0.0 2.3e-34 119.0 0.0 2.2 2 1 0 2 2 2 1 Peptidase M16 inactive domain BRCA-2_OB1 PF09103.10 CCM04459.1 - 6e-33 113.4 0.0 1.8e-32 111.9 0.0 1.8 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 CCM04459.1 - 6.8e-09 35.6 1.5 5.2e-07 29.5 1.5 2.3 1 1 0 1 1 1 1 BRCA2, helical Lum_binding PF00677.17 CCM04460.1 - 1.5e-35 121.0 0.1 2.1e-18 66.1 0.0 3.5 3 0 0 3 3 3 3 Lumazine binding domain UDPGP PF01704.18 CCM04463.1 - 7.5e-51 173.1 0.0 9.2e-51 172.8 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 CCM04463.1 - 0.015 15.6 0.2 0.041 14.2 0.2 1.9 1 1 0 1 1 1 0 MobA-like NTP transferase domain DUF4119 PF13494.6 CCM04463.1 - 0.12 12.5 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF4119) Taxilin PF09728.9 CCM04464.1 - 4e-14 52.5 45.8 9.4e-09 34.9 10.5 3.3 2 1 1 3 3 3 2 Myosin-like coiled-coil protein Rad60-SLD PF11976.8 CCM04464.1 - 2.7e-07 30.3 0.5 0.021 14.6 0.0 3.2 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CCM04464.1 - 6.5e-05 22.6 0.1 0.017 14.9 0.0 2.9 2 0 0 2 2 2 1 Ubiquitin family AIP3 PF03915.13 CCM04464.1 - 0.0033 16.6 15.2 0.0033 16.6 15.2 1.9 2 0 0 2 2 2 1 Actin interacting protein 3 PriA_C PF18074.1 CCM04464.1 - 0.15 12.9 4.9 0.089 13.6 0.7 2.8 2 1 1 3 3 3 0 Primosomal protein N C-terminal domain DUF2333 PF10095.9 CCM04464.1 - 0.22 10.5 2.5 0.37 9.7 2.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) CorA PF01544.18 CCM04464.1 - 0.75 9.0 13.2 5.7 6.2 0.0 3.2 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein Clp1 PF06807.14 CCM04464.1 - 1.2 9.6 4.4 1.6 9.2 0.0 2.7 3 0 0 3 3 3 0 Pre-mRNA cleavage complex II protein Clp1 DUF2935 PF11155.8 CCM04464.1 - 4.6 7.6 10.5 0.79 10.1 3.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) Ceramidase PF05875.12 CCM04465.1 - 9.5e-76 254.7 6.2 1.1e-75 254.5 6.2 1.0 1 0 0 1 1 1 1 Ceramidase Neurensin PF14927.6 CCM04465.1 - 0.011 15.5 2.3 6.4 6.5 0.2 3.4 3 0 0 3 3 3 0 Neurensin Myosin_head PF00063.21 CCM04466.1 - 3.3e-240 799.0 0.3 4e-240 798.7 0.3 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 CCM04466.1 - 4.2e-52 176.6 0.2 7.7e-52 175.7 0.2 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_2 PF07653.17 CCM04466.1 - 1.4e-08 34.3 0.0 3.3e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCM04466.1 - 2.9e-08 33.5 0.1 6.3e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCM04466.1 - 9.4e-08 31.6 0.8 1.9e-07 30.6 0.8 1.6 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 CCM04466.1 - 0.00038 20.7 0.5 0.0011 19.2 0.5 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain AAA_16 PF13191.6 CCM04466.1 - 0.06 13.7 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CCM04466.1 - 0.061 13.6 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.12 CCM04466.1 - 0.094 12.2 1.3 9.2 5.8 0.1 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain NACHT PF05729.12 CCM04466.1 - 0.14 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AMP-binding PF00501.28 CCM04467.1 - 4.3e-27 94.8 0.0 1.2e-26 93.4 0.0 1.6 1 1 0 2 2 2 1 AMP-binding enzyme PP-binding PF00550.25 CCM04467.1 - 0.00012 22.3 0.0 0.00024 21.4 0.0 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site UNC45-central PF11701.8 CCM04468.1 - 7.5e-24 84.4 0.9 1.6e-23 83.4 0.4 1.9 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central ERAP1_C PF11838.8 CCM04468.1 - 0.15 11.6 0.2 0.95 8.9 0.1 2.3 2 1 1 3 3 3 0 ERAP1-like C-terminal domain HEAT_2 PF13646.6 CCM04468.1 - 10 6.6 13.9 47 4.5 0.0 5.5 6 1 1 7 7 7 0 HEAT repeats Gcd10p PF04189.13 CCM04469.1 - 9.2e-67 225.3 0.0 1.7e-66 224.4 0.0 1.4 1 1 0 1 1 1 1 Gcd10p family PXA PF02194.15 CCM04470.1 - 1.3e-46 158.9 0.3 5.8e-46 156.8 0.3 2.2 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 CCM04470.1 - 6.8e-32 110.4 0.2 2.5e-31 108.6 0.0 2.2 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 CCM04470.1 - 2.6e-18 66.0 0.1 2.2e-17 63.1 0.0 2.5 2 0 0 2 2 2 1 PX domain RGS PF00615.19 CCM04470.1 - 1.7e-08 34.8 0.2 6.8e-08 32.8 0.0 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain GMC_oxred_N PF00732.19 CCM04471.1 - 2.7e-63 214.1 0.0 3.3e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM04471.1 - 1.6e-36 126.0 0.1 2.8e-36 125.2 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCM04471.1 - 3.4e-05 23.1 0.2 0.00059 19.0 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 CCM04471.1 - 0.0002 21.1 0.2 0.00068 19.3 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCM04471.1 - 0.0013 18.9 0.7 0.0046 17.2 0.7 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM04471.1 - 0.0018 17.5 0.2 0.003 16.9 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CCM04471.1 - 0.0067 16.7 0.1 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain Pyr_redox PF00070.27 CCM04471.1 - 0.0076 16.8 0.1 0.023 15.3 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCM04471.1 - 0.0089 15.1 0.2 0.013 14.5 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 CCM04471.1 - 0.025 13.9 0.1 0.037 13.3 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 CCM04471.1 - 0.032 13.5 0.0 0.079 12.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CCM04471.1 - 0.034 13.2 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Mito_carr PF00153.27 CCM04472.1 - 1e-41 140.7 0.4 1.5e-15 56.9 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein COesterase PF00135.28 CCM04473.1 - 2.8e-81 273.9 0.0 4e-81 273.4 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM04473.1 - 5.9e-09 36.1 0.0 1.7e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM04473.1 - 0.0036 16.8 0.0 0.0069 15.9 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family EccE PF11203.8 CCM04474.1 - 0.0021 18.4 0.0 1.7 9.0 0.0 2.3 1 1 1 2 2 2 2 Putative type VII ESX secretion system translocon, EccE DAO PF01266.24 CCM04475.1 - 7.4e-35 121.2 0.4 9.5e-35 120.8 0.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CCM04475.1 - 0.047 14.3 0.2 0.1 13.1 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 CCM04475.1 - 0.054 13.8 0.1 0.3 11.3 0.1 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Trp_halogenase PF04820.14 CCM04475.1 - 0.13 11.1 0.4 0.22 10.3 0.4 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Glu_dehyd_C PF16912.5 CCM04475.1 - 0.18 11.2 0.0 0.48 9.9 0.0 1.6 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Thr_synth_N PF14821.6 CCM04479.1 - 3.6e-27 94.4 0.0 1e-26 92.9 0.0 1.8 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 CCM04479.1 - 1.3e-16 60.9 0.0 3e-16 59.7 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme WD40 PF00400.32 CCM04480.1 - 2.4e-34 116.8 24.3 2.7e-07 31.2 0.0 8.8 9 1 0 9 9 9 6 WD domain, G-beta repeat Nup160 PF11715.8 CCM04480.1 - 3.6e-09 35.8 0.8 0.033 12.9 0.0 4.4 3 1 1 4 4 4 4 Nucleoporin Nup120/160 F-box-like PF12937.7 CCM04480.1 - 1e-08 34.9 2.6 2.2e-08 33.8 2.6 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CCM04480.1 - 6.7e-07 29.5 0.0 0.2 11.9 0.0 3.8 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 CCM04480.1 - 1e-06 28.4 2.7 2.6e-06 27.2 2.7 1.8 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 CCM04480.1 - 3.3e-06 26.7 0.0 0.16 11.2 0.0 3.1 3 0 0 3 3 3 3 WD40-like domain NT-C2 PF10358.9 CCM04481.1 - 1.7e-17 63.5 0.0 5.9e-13 48.8 0.0 2.2 2 0 0 2 2 2 2 N-terminal C2 in EEIG1 and EHBP1 proteins Iso_dh PF00180.20 CCM04482.1 - 1e-70 238.6 0.0 1.2e-70 238.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase SIR2 PF02146.17 CCM04483.1 - 7.6e-32 110.7 0.1 1.2e-30 106.8 0.1 2.4 1 1 0 1 1 1 1 Sir2 family PNTB PF02233.16 CCM04483.1 - 0.00088 18.3 1.0 0.0018 17.3 0.1 1.7 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.22 CCM04483.1 - 0.0074 16.0 0.0 0.038 13.7 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Ribosomal_L28 PF00830.19 CCM04484.1 - 6.1e-22 77.6 1.4 9.6e-22 77.0 1.4 1.3 1 0 0 1 1 1 1 Ribosomal L28 family Pkinase PF00069.25 CCM04485.1 - 3.2e-72 243.1 0.0 5.4e-72 242.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04485.1 - 6.9e-30 104.2 0.0 1.1e-29 103.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM04485.1 - 2.2e-07 30.5 0.0 3.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCM04485.1 - 0.00027 19.8 0.0 0.00027 19.8 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 CCM04485.1 - 0.00074 18.9 0.1 0.0014 18.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM04485.1 - 0.0093 15.9 0.0 0.036 14.0 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family PNP_UDP_1 PF01048.20 CCM04490.1 - 1.3e-36 126.1 0.3 1.7e-36 125.6 0.3 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily DUF2013 PF09431.10 CCM04492.1 - 1.2e-55 187.5 2.5 1.1e-54 184.3 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2013) PhzC-PhzF PF02567.16 CCM04493.1 - 1.4e-33 116.6 0.0 2.3e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein BTB PF00651.31 CCM04494.1 - 1.4e-07 31.7 0.0 2.5e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain AlbA_2 PF04326.14 CCM04494.1 - 0.063 13.6 0.0 0.29 11.4 0.0 2.0 2 0 0 2 2 2 0 Putative DNA-binding domain Glucan_synthase PF02364.15 CCM04495.1 - 0 1313.9 0.0 0 1313.5 0.0 1.1 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 CCM04495.1 - 3.1e-42 144.0 0.1 9.4e-42 142.4 0.1 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Asp PF00026.23 CCM04495.1 - 2.2e-20 73.3 0.2 4.5e-20 72.3 0.0 1.6 2 0 0 2 2 2 1 Eukaryotic aspartyl protease Velvet PF11754.8 CCM04496.1 - 7.9e-34 117.7 0.0 9.1e-33 114.2 0.0 2.2 1 1 0 1 1 1 1 Velvet factor UQ_con PF00179.26 CCM04497.1 - 1.8e-45 154.0 0.1 2.1e-45 153.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CCM04497.1 - 0.00012 21.8 0.1 0.00092 18.9 0.0 1.9 1 1 1 2 2 2 1 Prokaryotic E2 family B Nup54 PF13874.6 CCM04498.1 - 2.2e-41 141.3 3.1 4.1e-41 140.4 3.1 1.4 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 CCM04498.1 - 1.8e-32 112.0 375.0 2.4e-08 34.7 34.1 6.9 3 1 7 10 10 10 8 Nucleoporin FG repeat region WD40 PF00400.32 CCM04498.1 - 2.5e-19 69.3 0.3 9.5e-05 23.1 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04498.1 - 1.4e-08 34.9 0.0 0.00015 22.0 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup54_C PF18437.1 CCM04498.1 - 0.00083 19.2 0.1 0.0019 18.0 0.1 1.7 1 0 0 1 1 1 1 Nup54 C-terminal interacting domain eIF2A PF08662.11 CCM04498.1 - 0.0019 18.1 0.0 0.079 12.8 0.0 2.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A eIF-5_eIF-2B PF01873.17 CCM04499.1 - 2.2e-42 143.6 0.2 4e-42 142.8 0.2 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 CCM04499.1 - 0.0032 16.9 0.4 0.0081 15.6 0.4 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding zf-HYPF PF07503.12 CCM04499.1 - 0.28 11.0 4.7 5.2 6.9 0.0 3.1 4 0 0 4 4 4 0 HypF finger Arc_trans_TRASH PF08394.10 CCM04499.1 - 1.6 9.1 4.5 14 6.1 0.0 2.8 1 1 1 2 2 2 0 Archaeal TRASH domain ATP-synt PF00231.19 CCM04500.1 - 1.3e-79 267.9 5.8 1.4e-79 267.7 5.8 1.0 1 0 0 1 1 1 1 ATP synthase BRO1 PF03097.18 CCM04501.1 - 1.1e-119 399.8 1.7 2e-119 398.9 1.7 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CCM04501.1 - 1.1e-57 195.6 9.5 1.8e-57 194.9 9.5 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV TBCC_N PF16752.5 CCM04501.1 - 0.027 14.9 1.4 0.8 10.2 0.1 2.9 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain BLOC1_2 PF10046.9 CCM04501.1 - 0.094 13.0 3.7 6.3 7.2 0.7 3.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MerR-DNA-bind PF09278.11 CCM04501.1 - 0.31 11.6 1.5 1.5 9.4 0.2 2.6 2 0 0 2 2 2 0 MerR, DNA binding COG5 PF10392.9 CCM04501.1 - 6.7 6.9 6.4 9.3 6.4 0.2 3.2 2 1 1 3 3 3 0 Golgi transport complex subunit 5 Catalase PF00199.19 CCM04502.1 - 3.5e-151 503.7 0.9 1.1e-150 502.0 0.9 1.7 1 1 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CCM04502.1 - 3.2e-16 59.3 0.0 1.9e-15 56.8 0.0 2.3 3 0 0 3 3 3 1 Catalase-related immune-responsive TB2_DP1_HVA22 PF03134.19 CCM04503.1 - 2e-27 94.9 4.7 2e-27 94.9 4.7 1.6 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Frizzled PF01534.17 CCM04503.1 - 0.024 13.7 0.1 0.031 13.3 0.1 1.1 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region DUF2304 PF10066.9 CCM04503.1 - 0.027 14.7 0.3 0.044 14.0 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Pheromone PF08015.11 CCM04503.1 - 1.5 9.9 6.2 5.2 8.2 6.2 2.0 1 0 0 1 1 1 0 Fungal mating-type pheromone Ferritin_2 PF13668.6 CCM04504.1 - 1.4e-35 122.4 0.0 2.1e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain Ferritin_2 PF13668.6 CCM04505.1 - 7.4e-37 126.6 0.0 1.1e-36 126.0 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain Cerato-platanin PF07249.12 CCM04506.1 - 1.3e-44 151.1 2.0 1.6e-44 150.8 2.0 1.0 1 0 0 1 1 1 1 Cerato-platanin POC1 PF10450.9 CCM04506.1 - 0.05 12.6 0.0 0.071 12.1 0.0 1.3 1 0 0 1 1 1 0 POC1 chaperone PsbM PF05151.12 CCM04506.1 - 0.17 11.7 1.2 0.31 10.9 1.2 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre M protein (PsbM) HMG_box PF00505.19 CCM04507.1 - 4.4e-12 46.2 2.9 8.5e-12 45.3 2.9 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM04507.1 - 2.3e-05 24.9 1.0 4.2e-05 24.1 1.0 1.4 1 0 0 1 1 1 1 HMG-box domain Vpu PF00558.19 CCM04508.1 - 0.17 11.7 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Vpu protein ADH_N PF08240.12 CCM04509.1 - 3.7e-26 91.1 3.5 5.7e-26 90.5 3.5 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM04509.1 - 1.9e-16 60.3 0.0 4.4e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCM04509.1 - 2.9e-06 26.8 0.0 6.7e-06 25.6 0.0 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CCM04509.1 - 5.1e-06 27.6 0.0 7.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CCM04509.1 - 4.9e-05 22.8 0.0 0.00012 21.5 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CCM04509.1 - 0.02 15.1 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CCM04509.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain E1-E2_ATPase PF00122.20 CCM04510.1 - 7.7e-45 152.6 4.0 7.7e-45 152.6 4.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CCM04510.1 - 3.9e-23 82.1 19.0 5e-18 65.4 1.1 4.0 4 0 0 4 4 4 2 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CCM04510.1 - 1.4e-18 66.8 0.0 3.1e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCM04510.1 - 1.5e-16 61.3 0.0 9e-15 55.5 0.0 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CCM04510.1 - 1.4e-13 50.3 0.0 3e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCM04510.1 - 0.00031 20.5 0.6 0.032 14.0 0.4 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4231 PF14015.6 CCM04510.1 - 5.8 7.4 9.5 30 5.1 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Rpp20 PF12328.8 CCM04511.1 - 2.3e-06 27.6 0.0 0.00024 21.0 0.0 2.6 1 1 1 2 2 2 2 Rpp20 subunit of nuclear RNase MRP and P Prok-E2_B PF14461.6 CCM04511.1 - 0.038 13.7 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Alba PF01918.21 CCM04511.1 - 0.066 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Alba eRF1_2 PF03464.15 CCM04512.1 - 8.2e-47 158.8 0.1 1.5e-46 158.0 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CCM04512.1 - 5.7e-39 133.1 0.4 1.1e-38 132.1 0.4 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 CCM04512.1 - 1.5e-19 70.3 0.0 2.6e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 CCM04512.1 - 1.3e-10 41.7 0.2 2.3e-10 40.8 0.2 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 CCM04512.1 - 1e-08 35.6 0.1 1.7e-08 34.8 0.1 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 Phosducin PF02114.16 CCM04513.1 - 4.4e-05 22.6 0.0 7.4e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Phosducin p450 PF00067.22 CCM04514.1 - 1.7e-80 271.0 0.0 2.2e-80 270.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 CCM04514.1 - 3.4e-27 95.5 0.0 5.2e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CCM04514.1 - 4.8e-16 59.3 1.9 2.8e-12 47.0 0.2 2.8 2 1 1 3 3 3 2 Flavodoxin NAD_binding_1 PF00175.21 CCM04514.1 - 3.9e-08 33.9 0.0 8.7e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Ribonuclease_3 PF00636.26 CCM04515.1 - 6e-40 136.1 0.0 1e-20 74.3 0.0 2.5 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CCM04515.1 - 8.9e-29 100.2 0.2 2.4e-15 56.8 0.0 4.1 3 1 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.14 CCM04515.1 - 3.2e-16 59.2 0.0 1e-15 57.7 0.0 1.9 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 CCM04515.1 - 1.6e-14 54.2 0.0 3.2e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM04515.1 - 2.5e-14 53.7 0.0 4.7e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCM04515.1 - 4.9e-14 52.5 0.0 9.2e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CCM04515.1 - 0.00018 21.2 0.0 0.00041 20.1 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase CMD PF02627.20 CCM04516.1 - 0.00034 20.6 0.0 0.0068 16.4 0.1 2.4 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family RRM_1 PF00076.22 CCM04517.1 - 2.2e-34 117.1 0.0 1.6e-19 69.5 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 CCM04517.1 - 0.057 13.1 0.3 0.67 9.7 0.1 2.2 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_7 PF16367.5 CCM04517.1 - 0.071 13.2 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif RRM_5 PF13893.6 CCM04517.1 - 0.1 12.2 0.0 19 4.9 0.0 2.2 1 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) F-box-like PF12937.7 CCM04520.1 - 6.3e-08 32.4 1.9 1.4e-07 31.3 1.9 1.6 1 0 0 1 1 1 1 F-box-like Glycos_transf_1 PF00534.20 CCM04521.1 - 2.4e-20 72.8 0.0 3.8e-13 49.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CCM04521.1 - 2e-19 70.2 0.7 3.3e-19 69.5 0.7 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CCM04521.1 - 1.5e-11 45.0 0.1 1.1e-10 42.2 0.1 2.2 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CCM04521.1 - 1.8e-09 38.1 0.5 8e-08 32.8 0.0 2.8 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CCM04521.1 - 0.012 15.9 0.0 0.033 14.6 0.0 1.8 1 0 0 1 1 1 0 Glycosyl transferases group 1 Laminin_G_3 PF13385.6 CCM04522.1 - 0.0013 18.9 0.4 0.0042 17.3 0.1 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF4251 PF14059.6 CCM04522.1 - 0.094 12.7 0.0 6.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4251) Bac_export_2 PF01312.19 CCM04523.1 - 0.22 10.7 0.7 0.31 10.2 0.7 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family FA_desaturase PF00487.24 CCM04524.1 - 4.5e-26 92.2 28.6 1.2e-25 90.8 28.6 1.6 1 1 0 1 1 1 1 Fatty acid desaturase DUF2947 PF11163.8 CCM04525.1 - 0.066 13.1 0.2 0.098 12.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) Ccdc124 PF06244.12 CCM04526.1 - 8.1e-26 91.1 24.7 8.1e-26 91.1 24.7 2.3 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 Allexi_40kDa PF05549.11 CCM04526.1 - 0.36 10.3 2.0 0.44 10.0 0.0 1.9 2 0 0 2 2 2 0 Allexivirus 40kDa protein Zip PF02535.22 CCM04526.1 - 1.3 8.1 3.4 1.7 7.8 3.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CCM04526.1 - 6 5.5 8.8 8.5 5.0 8.8 1.3 1 0 0 1 1 1 0 Presenilin Calcipressin PF04847.12 CCM04527.1 - 2.5e-35 121.9 0.0 3.2e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Calcipressin DUF4381 PF14316.6 CCM04529.1 - 0.015 15.6 2.2 0.029 14.6 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) LapA_dom PF06305.11 CCM04529.1 - 0.026 14.3 0.2 0.055 13.3 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain TMEM100 PF16311.5 CCM04529.1 - 0.19 11.3 0.3 0.34 10.5 0.3 1.3 1 0 0 1 1 1 0 Transmembrane protein 100 Ras PF00071.22 CCM04530.1 - 3e-63 212.2 0.3 3.5e-63 212.0 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM04530.1 - 2e-35 121.6 0.0 3e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM04530.1 - 5e-16 58.6 0.0 6.8e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM04530.1 - 1.6e-05 24.4 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM04530.1 - 0.00012 22.1 0.0 0.00021 21.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCM04530.1 - 0.00013 21.6 0.1 0.00056 19.5 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM04530.1 - 0.00016 21.6 0.3 0.19 11.6 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 CCM04530.1 - 0.00068 19.1 0.0 0.00086 18.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 CCM04530.1 - 0.0028 18.1 0.0 0.0051 17.2 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.18 CCM04530.1 - 0.015 14.8 0.0 0.064 12.8 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA PF00004.29 CCM04530.1 - 0.032 14.7 0.1 0.69 10.3 0.0 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 CCM04530.1 - 0.04 13.7 0.0 0.12 12.2 0.0 1.6 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CCM04530.1 - 0.055 13.7 0.0 0.12 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCM04530.1 - 0.064 13.3 0.0 0.097 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 CCM04530.1 - 0.076 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 CCM04530.1 - 0.13 11.8 0.0 0.36 10.3 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 CCM04531.1 - 1.1e-42 145.6 0.0 1.9e-42 144.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCM04531.1 - 5.6e-12 45.3 0.1 1.3e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CCM04531.1 - 1.6e-10 40.7 0.0 3.5e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CCM04531.1 - 2.8e-07 30.6 0.1 4.2e-06 26.8 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCM04531.1 - 3.2e-07 30.9 0.0 0.00015 22.2 0.1 2.7 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 CCM04531.1 - 6e-06 26.5 0.0 3.2e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CCM04531.1 - 7.9e-06 25.7 0.0 1.9e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCM04531.1 - 0.00015 22.1 0.1 0.0052 17.1 0.0 2.3 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 CCM04531.1 - 0.0012 18.1 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CCM04531.1 - 0.002 18.6 0.0 0.007 16.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain Prot_ATP_OB_N PF17758.1 CCM04531.1 - 0.0023 17.5 0.0 0.0059 16.2 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain Mg_chelatase PF01078.21 CCM04531.1 - 0.0033 16.8 0.0 0.0064 15.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CCM04531.1 - 0.0037 17.6 0.0 0.0075 16.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 CCM04531.1 - 0.004 17.2 0.0 0.025 14.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CCM04531.1 - 0.0043 16.8 0.0 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 CCM04531.1 - 0.0044 16.6 0.0 0.0088 15.6 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region TsaE PF02367.17 CCM04531.1 - 0.0046 16.9 0.0 0.0083 16.1 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 CCM04531.1 - 0.0056 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 CCM04531.1 - 0.0073 16.5 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CCM04531.1 - 0.011 15.5 0.0 0.035 13.8 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 CCM04531.1 - 0.016 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CCM04531.1 - 0.018 14.9 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 CCM04531.1 - 0.018 14.5 0.1 0.034 13.6 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 CCM04531.1 - 0.021 14.5 0.1 0.051 13.3 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 CCM04531.1 - 0.026 14.8 0.0 0.061 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM04531.1 - 0.044 13.7 0.0 0.098 12.6 0.0 1.7 1 1 1 2 2 2 0 NACHT domain ATPase PF06745.13 CCM04531.1 - 0.058 12.7 0.9 0.19 11.1 0.0 2.2 3 0 0 3 3 3 0 KaiC AAA_25 PF13481.6 CCM04531.1 - 0.061 12.9 0.1 0.15 11.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CCM04531.1 - 0.067 12.5 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 CCM04531.1 - 0.067 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_23 PF13476.6 CCM04531.1 - 0.068 13.7 1.4 12 6.4 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.6 CCM04531.1 - 0.098 13.0 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CCM04531.1 - 0.12 12.2 1.3 0.37 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain IMS PF00817.20 CCM04532.1 - 8.3e-41 139.5 0.0 1.7e-40 138.5 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 CCM04532.1 - 1.8e-29 101.9 3.0 1.8e-29 101.9 3.0 2.2 3 0 0 3 3 3 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 CCM04532.1 - 9.6e-17 61.8 0.0 4.4e-16 59.6 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 CCM04532.1 - 1.6e-08 34.8 0.0 3.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain IMS_HHH PF11798.8 CCM04532.1 - 5.5e-06 26.4 0.0 1.6e-05 25.0 0.0 1.9 1 0 0 1 1 1 1 IMS family HHH motif BRCT PF00533.26 CCM04532.1 - 0.00095 19.5 0.0 0.0023 18.3 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CCM04532.1 - 0.0042 17.0 0.0 0.0096 15.8 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain DUF1805 PF08827.11 CCM04532.1 - 0.0092 16.3 0.0 0.028 14.7 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1805) UBM PF14377.6 CCM04532.1 - 0.27 10.8 1.9 5.3 6.6 0.0 3.5 4 0 0 4 4 4 0 Ubiquitin binding region Methyltransf_23 PF13489.6 CCM04533.1 - 5.1e-16 58.9 0.0 8.2e-16 58.3 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM04533.1 - 5.2e-14 52.7 0.0 1.2e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04533.1 - 1.5e-13 51.2 0.0 2.9e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM04533.1 - 2.3e-12 47.0 0.0 3.2e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM04533.1 - 1.8e-11 44.6 0.0 3.6e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM04533.1 - 2.9e-05 23.5 0.0 0.0001 21.7 0.0 1.6 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 CCM04533.1 - 0.056 12.5 0.0 0.083 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase p450 PF00067.22 CCM04534.1 - 4.5e-58 197.1 0.0 1.1e-50 172.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Glyco_transf_4 PF13439.6 CCM04534.1 - 0.06 13.3 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 p450 PF00067.22 CCM04535.1 - 6.5e-63 213.1 0.0 9.2e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CCM04535.1 - 4.7e-36 124.4 25.1 4.7e-36 124.4 25.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM04535.1 - 5.6e-05 22.2 10.5 5.6e-05 22.2 10.5 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 CCM04535.1 - 6.7 4.9 6.0 2.3 6.4 1.2 2.2 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Ubie_methyltran PF01209.18 CCM04536.1 - 0.00031 20.2 0.2 0.00062 19.2 0.2 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF4320 PF14208.6 CCM04536.1 - 0.071 13.2 2.3 0.49 10.5 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4320) Flavodoxin_1 PF00258.25 CCM04536.1 - 0.073 13.3 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 Flavodoxin Aegerolysin PF06355.13 CCM04537.1 - 1.8e-48 164.0 0.2 2.1e-48 163.7 0.2 1.1 1 0 0 1 1 1 1 Aegerolysin Glyco_hydro_31 PF01055.26 CCM04538.1 - 1.6e-140 469.2 2.1 2e-140 468.9 2.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CCM04538.1 - 3.2e-35 120.8 0.0 5.9e-35 120.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CCM04538.1 - 3.9e-11 43.1 0.3 1.1e-10 41.6 0.3 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like Myb_DNA-bind_2 PF08914.11 CCM04539.1 - 2e-18 66.3 8.5 7.7e-11 42.0 3.5 2.8 2 0 0 2 2 2 2 Rap1 Myb domain Pkinase PF00069.25 CCM04540.1 - 3.2e-46 157.8 0.0 4.1e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04540.1 - 2.8e-25 89.1 0.0 4e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM04540.1 - 0.00029 19.7 0.2 0.0012 17.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCM04540.1 - 0.00058 19.3 0.0 0.002 17.5 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CCM04540.1 - 0.0078 15.2 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CCM04540.1 - 0.059 13.3 0.4 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Tho2 PF11262.8 CCM04540.1 - 0.071 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 WTX PF09422.10 CCM04542.1 - 1.8 7.6 11.7 1.9 7.5 11.7 1.0 1 0 0 1 1 1 0 WTX protein Shugoshin_C PF07557.11 CCM04543.1 - 1.5e-08 34.3 3.5 1.5e-08 34.3 3.5 2.9 2 0 0 2 2 2 1 Shugoshin C terminus Shugoshin_N PF07558.11 CCM04543.1 - 3.4e-07 30.0 2.1 7e-07 29.0 2.1 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Rtf2 PF04641.12 CCM04543.1 - 0.48 9.7 7.7 1 8.7 7.7 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger PIEZO PF15917.5 CCM04543.1 - 1.1 8.7 4.8 2.4 7.6 4.8 1.5 1 0 0 1 1 1 0 Piezo Myb_DNA-bind_2 PF08914.11 CCM04544.1 - 0.031 14.4 1.5 0.13 12.5 1.5 2.1 1 1 0 1 1 1 0 Rap1 Myb domain BRCT_2 PF16589.5 CCM04544.1 - 0.081 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Rap1-DNA-bind PF09197.10 CCM04544.1 - 1.1 9.8 5.8 15 6.2 5.8 2.5 1 1 0 1 1 1 0 Rap1, DNA-binding MFS_1 PF07690.16 CCM04545.1 - 7.9e-43 146.7 42.4 2.4e-40 138.6 43.9 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM04545.1 - 2.7e-08 32.7 11.8 3e-08 32.5 11.3 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM04545.1 - 2.3e-06 26.8 29.5 0.00013 20.9 8.0 3.9 2 2 1 4 4 4 3 Sugar (and other) transporter HlyIII PF03006.20 CCM04545.1 - 0.0024 17.6 6.1 0.0059 16.3 0.9 2.5 1 1 0 2 2 2 1 Haemolysin-III related YscK PF06578.12 CCM04545.1 - 0.025 14.1 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) Oxidored_q2 PF00420.24 CCM04545.1 - 0.058 13.0 1.7 0.28 10.8 1.7 2.2 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L E1-E2_ATPase PF00122.20 CCM04545.1 - 0.11 12.0 3.0 2.8 7.4 0.0 2.8 3 0 0 3 3 3 0 E1-E2 ATPase PGG PF13962.6 CCM04545.1 - 4.4 7.1 7.9 9.8 6.0 0.6 3.7 4 0 0 4 4 4 0 Domain of unknown function DUF2530 PF10745.9 CCM04545.1 - 6.3 7.1 8.8 1.1 9.5 0.2 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2530) Cyclase PF04199.13 CCM04546.1 - 2.7e-14 53.6 0.0 3.8e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Putative cyclase Aegerolysin PF06355.13 CCM04547.1 - 5.9e-47 159.0 1.2 8e-47 158.6 1.2 1.2 1 0 0 1 1 1 1 Aegerolysin Ubie_methyltran PF01209.18 CCM04548.1 - 0.00012 21.5 0.3 0.00028 20.3 0.3 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF4320 PF14208.6 CCM04548.1 - 0.013 15.6 1.1 0.14 12.2 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) Cyclase PF04199.13 CCM04549.1 - 8.1e-14 52.0 0.0 1.6e-13 51.1 0.0 1.4 1 1 0 1 1 1 1 Putative cyclase Pkinase PF00069.25 CCM04550.1 - 1.3e-49 169.0 0.4 2.1e-49 168.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04550.1 - 2.5e-24 86.0 0.0 5.6e-24 84.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM04550.1 - 0.00087 18.2 0.4 0.00087 18.2 0.4 1.7 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 CCM04550.1 - 0.0092 15.6 0.4 0.74 9.4 0.4 2.8 1 1 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.11 CCM04550.1 - 0.015 14.3 1.0 0.015 14.3 0.1 1.4 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase MAGUK_N_PEST PF10608.9 CCM04550.1 - 0.98 9.9 4.7 1.7 9.1 2.9 2.2 2 0 0 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK p450 PF00067.22 CCM04551.1 - 6.5e-45 153.7 0.0 8.7e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FA_desaturase PF00487.24 CCM04552.1 - 6.5e-15 55.6 22.1 6.5e-15 55.6 22.1 1.9 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCM04552.1 - 2.1e-14 53.4 0.0 3.6e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PP2C PF00481.21 CCM04553.1 - 3.4e-31 108.8 0.0 5.4e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CCM04553.1 - 1.6e-05 25.0 0.1 0.0012 18.8 0.0 3.0 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CCM04553.1 - 0.0018 17.9 0.0 0.0087 15.7 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C ABC2_membrane PF01061.24 CCM04556.1 - 1.4e-69 233.7 53.5 1.7e-41 142.0 20.8 2.7 4 0 0 4 4 2 2 ABC-2 type transporter ABC_tran PF00005.27 CCM04556.1 - 1.8e-36 125.6 0.0 2.9e-17 63.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CCM04556.1 - 5.4e-32 109.6 14.7 1.4e-30 105.1 0.4 3.5 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 CCM04556.1 - 3.2e-07 30.9 0.1 7.8e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 CCM04556.1 - 1.9e-06 28.4 0.1 0.0017 18.7 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CCM04556.1 - 3.8e-06 26.9 0.0 9.1e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CCM04556.1 - 4.1e-06 27.1 0.1 0.073 13.3 0.1 3.0 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCM04556.1 - 8.2e-05 22.3 0.0 0.011 15.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 CCM04556.1 - 0.00083 19.4 0.1 0.66 10.1 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 CCM04556.1 - 0.00092 19.2 0.0 0.54 10.2 0.1 2.8 3 0 0 3 3 2 1 NACHT domain AAA_29 PF13555.6 CCM04556.1 - 0.0012 18.5 0.7 0.24 11.1 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 CCM04556.1 - 0.0019 18.7 0.0 0.38 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 CCM04556.1 - 0.0021 17.2 22.0 0.0021 17.2 22.0 3.1 2 1 1 3 3 3 1 ABC-2 family transporter protein AAA_33 PF13671.6 CCM04556.1 - 0.015 15.5 0.0 2.1 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CCM04556.1 - 0.016 15.0 0.0 3.5 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system dNK PF01712.19 CCM04556.1 - 0.021 14.7 0.0 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_30 PF13604.6 CCM04556.1 - 0.027 14.2 0.1 1.9 8.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 CCM04556.1 - 0.034 13.4 0.0 8.4 5.6 0.0 2.3 2 0 0 2 2 2 0 Septin cobW PF02492.19 CCM04556.1 - 0.052 13.1 0.4 1.1 8.8 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 CCM04556.1 - 0.059 12.8 0.0 3 7.2 0.0 3.0 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain PduV-EutP PF10662.9 CCM04556.1 - 0.075 12.8 0.5 4.4 7.0 0.1 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 CCM04556.1 - 0.15 12.5 0.0 14 6.2 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.6 CCM04556.1 - 0.16 12.5 0.1 0.3 11.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CCM04556.1 - 0.19 11.6 0.0 25 4.7 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain FtsK_SpoIIIE PF01580.18 CCM04556.1 - 0.19 11.0 0.3 2.7 7.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family ketoacyl-synt PF00109.26 CCM04557.1 - 4.1e-47 160.9 0.2 1.5e-46 159.0 0.2 2.0 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCM04557.1 - 3e-39 135.4 0.0 1.1e-38 133.6 0.0 1.8 1 1 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCM04557.1 - 4.1e-27 94.6 0.9 8.2e-27 93.6 0.9 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCM04557.1 - 9.2e-22 77.6 0.0 1.8e-21 76.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thioesterase PF00975.20 CCM04557.1 - 2.3e-19 70.5 0.0 4.4e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain KR PF08659.10 CCM04557.1 - 9.3e-19 68.0 0.3 2.2e-17 63.6 0.0 2.3 2 0 0 2 2 2 1 KR domain Methyltransf_12 PF08242.12 CCM04557.1 - 3.8e-13 50.0 0.0 1e-12 48.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM04557.1 - 1.7e-11 44.2 0.0 3.3e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CCM04557.1 - 1.1e-08 35.3 0.1 2.8e-08 34.0 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 CCM04557.1 - 2.5e-07 30.6 0.0 6.3e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04557.1 - 3.4e-07 30.8 0.0 2.5e-06 28.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM04557.1 - 3e-06 27.9 0.0 1.5e-05 25.6 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CCM04557.1 - 2.8e-05 23.6 0.4 8.3e-05 22.1 0.3 1.8 1 1 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCM04557.1 - 0.00038 20.2 3.0 0.0062 16.4 1.7 3.4 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III adh_short PF00106.25 CCM04557.1 - 0.00072 19.1 0.0 0.093 12.2 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase zf-RING_11 PF17123.5 CCM04557.1 - 0.0088 15.8 0.1 0.026 14.3 0.1 1.8 1 0 0 1 1 1 1 RING-like zinc finger KAsynt_C_assoc PF16197.5 CCM04557.1 - 0.023 15.1 0.2 0.15 12.6 0.0 2.4 2 1 1 3 3 3 0 Ketoacyl-synthetase C-terminal extension Ubie_methyltran PF01209.18 CCM04557.1 - 0.037 13.4 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family ADH_zinc_N PF00107.26 CCM04557.1 - 0.061 13.3 0.0 0.25 11.3 0.0 2.0 1 0 0 1 1 1 0 Zinc-binding dehydrogenase PCMT PF01135.19 CCM04557.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GDP_Man_Dehyd PF16363.5 CCM04558.1 - 4.8e-156 519.3 0.0 5.5e-156 519.1 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CCM04558.1 - 2e-72 243.6 0.0 2.6e-72 243.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCM04558.1 - 0.0006 19.0 0.0 0.00095 18.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CCM04558.1 - 0.008 15.3 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CCM04558.1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family zf-MYND PF01753.18 CCM04559.1 - 6e-08 32.7 7.5 1.1e-07 31.9 7.5 1.4 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 CCM04559.1 - 1.7 9.0 6.3 3.8 7.9 6.3 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Cellulase PF00150.18 CCM04560.1 - 3.3e-12 46.4 0.2 3.6e-08 33.2 0.1 2.8 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 CCM04560.1 - 3.8e-10 40.2 0.1 5.7e-08 33.2 0.1 2.6 2 0 0 2 2 2 2 Glycoside hydrolase family 5 C-terminal domain Lipase_3 PF01764.25 CCM04561.1 - 2e-07 31.0 0.1 2e-05 24.5 0.1 2.3 1 1 1 2 2 2 2 Lipase (class 3) PGAP1 PF07819.13 CCM04561.1 - 0.072 12.8 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein UPF0227 PF05728.12 CCM04561.1 - 0.082 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.7 CCM04561.1 - 0.19 12.3 4.7 0.061 13.9 1.4 1.8 1 1 0 2 2 2 0 Alpha/beta hydrolase family eIF2A PF08662.11 CCM04562.1 - 1.3e-74 250.3 0.0 2.1e-72 243.1 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 CCM04562.1 - 0.0097 15.6 7.6 2.9 7.6 0.1 4.7 4 0 0 4 4 4 2 Proteasome subunit A N-terminal signature WD40 PF00400.32 CCM04562.1 - 0.012 16.5 0.7 0.27 12.2 0.1 3.3 4 0 0 4 4 4 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04562.1 - 0.015 15.6 0.0 35 4.8 0.0 4.1 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain CDV3 PF15359.6 CCM04562.1 - 1.6 9.2 4.4 4.4 7.8 4.4 1.7 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 ORC6 PF05460.13 CCM04562.1 - 5.5 6.2 6.3 9.2 5.4 6.3 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) OPA3 PF07047.12 CCM04563.1 - 2.9e-13 49.7 0.8 3.4e-13 49.4 0.0 1.5 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) SesA PF17107.5 CCM04563.1 - 0.00083 19.5 0.0 0.0011 19.1 0.0 1.1 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases ZapB PF06005.12 CCM04563.1 - 0.002 18.6 2.2 0.0033 17.8 2.2 1.3 1 0 0 1 1 1 1 Cell division protein ZapB Sec34 PF04136.15 CCM04563.1 - 0.046 13.6 1.5 0.062 13.2 1.5 1.1 1 0 0 1 1 1 0 Sec34-like family DUF773 PF05600.12 CCM04563.1 - 0.048 12.4 1.8 0.061 12.1 1.8 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 Dor1 PF04124.12 CCM04563.1 - 0.053 12.2 1.5 0.071 11.8 1.5 1.1 1 0 0 1 1 1 0 Dor1-like family HLH PF00010.26 CCM04563.1 - 0.086 12.8 0.4 0.13 12.2 0.4 1.3 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain LMBR1 PF04791.16 CCM04563.1 - 0.26 10.2 0.0 0.28 10.0 0.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RmuC PF02646.16 CCM04563.1 - 0.33 10.0 3.5 0.39 9.8 3.2 1.3 1 1 0 1 1 1 0 RmuC family DivIC PF04977.15 CCM04563.1 - 1 9.2 3.5 2.1 8.2 3.5 1.6 1 1 0 1 1 1 0 Septum formation initiator IPK PF03770.16 CCM04564.1 - 2.9e-40 138.3 0.0 2.1e-39 135.5 0.0 2.0 1 1 0 1 1 1 1 Inositol polyphosphate kinase CDC45 PF02724.14 CCM04564.1 - 0.00058 18.3 4.1 0.00064 18.2 4.1 1.1 1 0 0 1 1 1 1 CDC45-like protein BAF1_ABF1 PF04684.13 CCM04564.1 - 0.0012 18.0 0.9 0.0016 17.6 0.9 1.1 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor Tim54 PF11711.8 CCM04564.1 - 0.04 12.7 0.2 0.058 12.2 0.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Mpp10 PF04006.12 CCM04564.1 - 0.041 12.3 11.7 0.053 12.0 11.7 1.1 1 0 0 1 1 1 0 Mpp10 protein Presenilin PF01080.17 CCM04564.1 - 0.23 10.2 0.2 0.32 9.7 0.2 1.1 1 0 0 1 1 1 0 Presenilin BUD22 PF09073.10 CCM04564.1 - 0.47 9.7 12.6 0.68 9.2 12.6 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CCM04564.1 - 0.47 8.6 17.9 0.66 8.1 17.9 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 CCM04564.1 - 1 7.4 23.8 1.4 7.0 23.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi V_ATPase_I PF01496.19 CCM04564.1 - 1.7 6.5 3.1 2.4 6.0 3.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Afi1 PF07792.12 CCM04564.1 - 2.4 8.6 10.4 4.3 7.8 10.4 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2076 PF09849.9 CCM04564.1 - 3.8 7.5 15.4 5.7 6.9 15.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4820 PF16091.5 CCM04564.1 - 4.4 6.6 6.6 6.4 6.1 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Vfa1 PF08432.10 CCM04564.1 - 6.3 7.1 8.1 11 6.3 8.1 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC73_C PF05179.14 CCM04565.1 - 7.3e-54 181.7 1.0 1.3e-53 180.9 1.0 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 CCM04565.1 - 3.6e-06 26.5 0.0 0.062 12.6 0.0 2.4 1 1 1 2 2 2 2 Paf1 complex subunit CDC73 N-terminal DUF4577 PF15145.6 CCM04565.1 - 0.073 13.1 0.0 6 6.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) RhoGEF PF00621.20 CCM04566.1 - 2.5e-41 141.9 1.1 4.8e-41 141.0 1.1 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.28 CCM04566.1 - 2.3e-20 72.0 0.5 1e-11 44.3 0.1 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CCM04566.1 - 2.3e-19 69.0 2.7 4.9e-09 35.9 0.5 2.5 2 0 0 2 2 2 2 Variant SH3 domain EF-hand_4 PF12763.7 CCM04566.1 - 6.4e-17 61.4 0.0 1.4e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand PH_13 PF16652.5 CCM04566.1 - 4.8e-13 49.2 0.0 9.4e-11 41.8 0.0 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain SH3_2 PF07653.17 CCM04566.1 - 1.3e-11 44.0 0.0 1.9e-05 24.3 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain WH2 PF02205.20 CCM04566.1 - 1.7e-09 37.2 0.7 4.4e-09 35.9 0.7 1.8 1 0 0 1 1 1 1 WH2 motif PH PF00169.29 CCM04566.1 - 4.1e-05 24.0 0.0 8.2e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 CCM04566.1 - 7.7e-05 22.0 0.0 0.057 13.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CCM04566.1 - 0.0027 18.1 0.0 0.0094 16.4 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CCM04566.1 - 0.021 14.7 0.0 3.7 7.7 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.6 CCM04566.1 - 0.16 11.8 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair Importin_rep_4 PF18808.1 CCM04566.1 - 1 9.7 8.5 0.044 14.1 0.6 2.7 2 0 0 2 2 2 0 Importin repeat SUV3_C PF12513.8 CCM04569.1 - 1.5e-15 56.9 0.0 3.6e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 CCM04569.1 - 4.2e-12 46.4 0.0 7.6e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4771 PF15995.5 CCM04569.1 - 0.00052 20.3 0.1 0.0024 18.1 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4771) Suv3_C_1 PF18147.1 CCM04569.1 - 0.0058 16.5 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 MRP-S33 PF08293.11 CCM04570.1 - 3.5e-30 104.1 0.1 7.2e-30 103.1 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 p450 PF00067.22 CCM04571.1 - 3.2e-10 39.4 0.2 6.2e-10 38.4 0.0 1.4 2 0 0 2 2 2 1 Cytochrome P450 tRNA-synt_1b PF00579.25 CCM04572.1 - 2e-72 244.0 0.0 2.5e-72 243.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) CK2S PF15011.6 CCM04572.1 - 0.055 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Casein Kinase 2 substrate Mak10 PF04112.13 CCM04573.1 - 6.9e-51 172.1 0.0 1.2e-50 171.3 0.0 1.4 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase HhH-GPD PF00730.25 CCM04574.1 - 3e-44 149.9 0.0 1.7e-22 79.9 0.0 2.4 2 0 0 2 2 2 2 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCM04574.1 - 1.2e-17 62.7 0.0 2.2e-07 30.4 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_5 PF14520.6 CCM04574.1 - 1.3e-05 25.7 0.7 2 9.1 0.0 4.2 4 0 0 4 4 4 2 Helix-hairpin-helix domain ParE-like_toxin PF15781.5 CCM04574.1 - 0.078 13.0 0.0 5.8 7.0 0.0 2.4 2 0 0 2 2 2 0 ParE-like toxin of type II bacterial toxin-antitoxin system HHH_3 PF12836.7 CCM04574.1 - 0.16 12.2 0.0 37 4.7 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif Phos_pyr_kin PF08543.12 CCM04575.1 - 1e-81 274.0 1.4 2.4e-80 269.5 1.4 2.1 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 CCM04575.1 - 2.1e-43 148.6 0.0 4e-43 147.7 0.0 1.5 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 CCM04575.1 - 0.00016 21.1 0.0 0.033 13.5 0.0 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase RTA1 PF04479.13 CCM04576.1 - 3.9e-65 219.3 10.5 4.9e-65 219.0 10.5 1.1 1 0 0 1 1 1 1 RTA1 like protein FBPase PF00316.20 CCM04577.1 - 3.4e-74 248.4 0.1 4.3e-74 248.1 0.1 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CCM04577.1 - 0.0014 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family RdRP PF05183.12 CCM04578.1 - 3.2e-166 554.4 0.0 4.2e-166 554.0 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Pmp3 PF01679.17 CCM04579.1 - 3.1e-16 59.3 4.6 4.1e-16 58.9 4.6 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator TPPK_C PF12555.8 CCM04579.1 - 0.048 13.7 0.0 0.081 13.0 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal PNGaseA PF12222.8 CCM04580.1 - 1.1e-141 472.7 5.1 1.4e-141 472.3 5.1 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A HTH_45 PF14947.6 CCM04580.1 - 0.0033 17.4 0.2 0.0073 16.3 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DUF5123 PF17161.4 CCM04580.1 - 0.31 12.1 8.7 0.48 11.5 0.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5123) BACON PF13004.7 CCM04580.1 - 0.37 10.8 3.9 0.37 10.8 0.1 2.9 3 0 0 3 3 3 0 Putative binding domain, N-terminal FTHFS PF01268.19 CCM04581.1 - 1.9e-256 851.7 0.2 3.1e-256 850.9 0.0 1.4 2 0 0 2 2 2 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 CCM04581.1 - 5.6e-67 224.0 0.2 1.7e-66 222.4 0.2 1.9 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CCM04581.1 - 2.6e-37 127.6 0.2 6.9e-37 126.3 0.2 1.8 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GrpE PF01025.19 CCM04582.1 - 3.5e-44 150.4 0.0 5.1e-44 149.9 0.0 1.2 1 0 0 1 1 1 1 GrpE tRNA-synt_2d PF01409.20 CCM04583.1 - 1.5e-45 155.6 0.0 1.3e-26 93.6 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 CCM04583.1 - 3e-22 78.8 0.0 6.3e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain GCIP PF13324.6 CCM04584.1 - 8.7e-38 130.4 0.0 1.7e-37 129.5 0.0 1.4 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Phasin_2 PF09361.10 CCM04584.1 - 0.12 12.7 1.0 0.68 10.2 0.3 2.4 2 0 0 2 2 2 0 Phasin protein Torus PF16131.5 CCM04585.1 - 1e-08 35.8 0.0 2.1e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 CCM04585.1 - 7.5e-06 25.8 3.6 2.6e-05 24.1 3.6 2.0 1 0 0 1 1 1 1 Zinc finger domain RRM_1 PF00076.22 CCM04585.1 - 3.3e-05 23.6 0.0 5.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 CCM04585.1 - 8.2e-05 22.4 3.3 0.00022 21.1 3.3 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_occluded PF16842.5 CCM04585.1 - 0.0036 17.1 0.0 0.0077 16.1 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif zf-CCCH_4 PF18044.1 CCM04585.1 - 0.0044 16.8 3.0 0.012 15.4 3.0 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CCM04585.1 - 0.0084 16.3 0.3 0.032 14.5 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 CCM04585.1 - 0.027 14.9 1.3 0.065 13.7 1.3 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF2039 PF10217.9 CCM04585.1 - 0.8 10.1 6.1 1 9.7 2.3 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) RTA1 PF04479.13 CCM04586.1 - 6.1e-29 101.1 3.9 6.9e-29 100.9 3.9 1.0 1 0 0 1 1 1 1 RTA1 like protein ThiF PF00899.21 CCM04587.1 - 9.8e-60 201.9 0.0 1.3e-59 201.5 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 CCM04587.1 - 3.1e-28 97.7 0.2 4.8e-28 97.1 0.2 1.3 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 CCM04587.1 - 0.011 15.8 0.1 0.025 14.6 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 CCM04587.1 - 0.045 13.3 0.1 0.085 12.4 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 CCM04587.1 - 0.078 13.5 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CCM04587.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PglD_N PF17836.1 CCM04587.1 - 0.15 12.7 0.2 0.38 11.4 0.2 1.7 1 0 0 1 1 1 0 PglD N-terminal domain RTC PF01137.21 CCM04588.1 - 1.8e-55 187.6 0.0 2.1e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 CCM04588.1 - 2.6e-39 133.9 0.0 3.9e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain NPR2 PF06218.11 CCM04589.1 - 1.6e-89 300.7 1.2 3.2e-70 237.1 2.9 3.8 2 1 1 3 3 3 2 Nitrogen permease regulator 2 ketoacyl-synt PF00109.26 CCM04590.1 - 2.3e-57 194.4 1.0 1.4e-56 191.9 1.6 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCM04590.1 - 3.9e-37 128.4 0.0 9e-37 127.3 0.0 1.6 1 1 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CCM04590.1 - 1.3e-36 126.2 0.0 3.1e-36 125.0 0.0 1.6 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 CCM04590.1 - 7.1e-27 93.8 0.1 1.5e-26 92.7 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCM04590.1 - 2e-23 83.1 0.0 3.6e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thioesterase PF00975.20 CCM04590.1 - 5.5e-20 72.5 0.0 1.2e-19 71.4 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain Methyltransf_12 PF08242.12 CCM04590.1 - 1.4e-12 48.2 0.0 4.2e-12 46.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM04590.1 - 1.5e-12 47.6 0.0 3.7e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CCM04590.1 - 1.6e-09 38.2 0.0 1e-08 35.6 0.0 2.4 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 CCM04590.1 - 1.8e-08 34.6 0.1 4.7e-08 33.3 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CCM04590.1 - 5.7e-08 32.4 0.0 9.3e-06 25.2 0.0 2.8 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_31 PF13847.6 CCM04590.1 - 7.5e-08 32.3 0.0 1.9e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04590.1 - 4.8e-07 30.3 0.1 2.6e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM04590.1 - 8.1e-06 26.5 0.1 3.4e-05 24.5 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Thiolase_N PF00108.23 CCM04590.1 - 0.00023 20.6 1.0 0.0005 19.5 0.1 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CCM04590.1 - 0.0022 17.8 2.5 0.019 14.8 2.5 2.7 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ADH_zinc_N PF00107.26 CCM04590.1 - 0.018 15.0 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 1 0 Zinc-binding dehydrogenase PCMT PF01135.19 CCM04590.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ADH_zinc_N_2 PF13602.6 CCM04590.1 - 0.11 13.5 0.0 2.1 9.4 0.0 2.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Ubie_methyltran PF01209.18 CCM04590.1 - 0.18 11.1 0.0 0.35 10.2 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Aldo_ket_red PF00248.21 CCM04591.1 - 4.5e-35 121.3 0.0 5.7e-31 107.8 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Snf7 PF03357.21 CCM04593.1 - 9.5e-16 57.9 14.1 1.6e-15 57.2 14.1 1.3 1 0 0 1 1 1 1 Snf7 Tweety PF04906.13 CCM04593.1 - 0.27 9.9 0.8 0.45 9.1 0.8 1.3 1 0 0 1 1 1 0 Tweety Baculo_PEP_C PF04513.12 CCM04593.1 - 0.42 10.6 2.8 0.27 11.3 0.9 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Seryl_tRNA_N PF02403.22 CCM04593.1 - 1.7 8.9 15.1 0.2 11.9 2.2 3.4 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.11 CCM04593.1 - 2.1 8.4 8.1 0.099 12.7 1.9 2.0 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 COX16 PF14138.6 CCM04593.1 - 2.9 8.5 4.7 1.2 9.7 0.2 2.4 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 NPV_P10 PF05531.12 CCM04593.1 - 3.8 8.0 7.1 8.4 6.9 1.0 3.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 CCM04593.1 - 5.4 7.6 8.9 0.74 10.3 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 TMEM51 PF15345.6 CCM04594.1 - 4.2e-06 26.8 0.0 1.5e-05 24.9 0.0 1.9 1 0 0 1 1 1 1 Transmembrane protein 51 TMEM154 PF15102.6 CCM04594.1 - 0.0066 16.4 1.1 0.012 15.6 0.0 1.9 2 0 0 2 2 2 1 TMEM154 protein family DUF1180 PF06679.12 CCM04594.1 - 0.05 14.0 0.1 0.05 14.0 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1180) Mid2 PF04478.12 CCM04594.1 - 0.078 12.8 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SNF2_N PF00176.23 CCM04596.1 - 7.5e-55 186.0 0.0 1.1e-54 185.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 CCM04596.1 - 3.5e-43 147.9 7.6 6.2e-43 147.0 7.6 1.4 1 0 0 1 1 1 1 Rad54 N terminal Helicase_C PF00271.31 CCM04596.1 - 8.5e-18 64.7 0.0 2.1e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CCM04596.1 - 2.2e-06 27.1 0.0 2.2e-06 27.1 0.0 2.3 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 CCM04596.1 - 5.8e-06 25.7 0.1 1.2e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CCM04596.1 - 4.2e-05 23.6 0.0 0.00015 21.8 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit U1snRNP70_N PF12220.8 CCM04596.1 - 0.067 13.8 0.3 0.067 13.8 0.3 2.5 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal GYF PF02213.16 CCM04597.1 - 1.6e-06 27.7 0.4 3.2e-06 26.7 0.4 1.6 1 0 0 1 1 1 1 GYF domain HicA_toxin PF07927.12 CCM04597.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, TMCO5 PF14992.6 CCM04597.1 - 0.066 12.8 3.8 0.11 12.0 3.8 1.3 1 0 0 1 1 1 0 TMCO5 family SPT16 PF08644.11 CCM04597.1 - 0.15 12.2 1.0 0.32 11.2 1.0 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) PQ-loop PF04193.14 CCM04598.1 - 9.1e-35 118.2 10.7 2e-17 62.7 0.0 2.9 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.16 CCM04598.1 - 0.0058 16.6 0.7 0.016 15.2 0.7 1.7 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange CLTH PF10607.9 CCM04599.1 - 1.1e-11 44.8 0.0 1.8e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CCM04599.1 - 0.036 14.0 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 LisH Ribosomal_L30_N PF08079.12 CCM04601.1 - 4.7e-27 94.1 17.3 4.7e-27 94.1 17.3 1.7 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 CCM04601.1 - 1.4e-18 66.5 2.4 1.8e-18 66.1 0.9 2.1 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Tipalpha PF16753.5 CCM04601.1 - 0.32 10.8 5.5 0.34 10.7 0.1 2.6 1 1 1 2 2 2 0 TNF-alpha-Inducing protein of Helicobacter p450 PF00067.22 CCM04602.1 - 4.2e-74 250.0 0.0 4.9e-74 249.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Reticulon PF02453.17 CCM04602.1 - 0.18 11.8 0.0 0.43 10.5 0.0 1.6 1 0 0 1 1 1 0 Reticulon DNA_methylase PF00145.17 CCM04603.1 - 5.2e-41 141.1 0.0 1.4e-40 139.6 0.0 1.7 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase DNMT1-RFD PF12047.8 CCM04603.1 - 2e-09 37.6 0.0 3.8e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain BAH PF01426.18 CCM04603.1 - 9.3e-06 25.5 0.2 0.093 12.6 0.1 2.9 2 1 0 2 2 2 2 BAH domain Met_10 PF02475.16 CCM04603.1 - 0.17 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein PAC3 PF10178.9 CCM04605.1 - 0.00026 21.1 1.4 0.0093 16.1 1.4 2.8 1 1 0 1 1 1 1 Proteasome assembly chaperone 3 NCE101 PF11654.8 CCM04606.1 - 1.5e-17 63.0 1.1 1.6e-17 62.9 0.1 1.5 2 0 0 2 2 2 1 Non-classical export protein 1 NatB_MDM20 PF09797.9 CCM04607.1 - 5.4e-74 249.4 4.4 5.4e-74 249.4 4.4 1.8 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit RPA_C PF08784.11 CCM04607.1 - 6.9e-09 36.3 0.0 2.6e-08 34.4 0.0 2.0 1 0 0 1 1 1 1 Replication protein A C terminal TPR_14 PF13428.6 CCM04607.1 - 2.2e-07 31.1 0.3 0.05 14.4 0.0 5.8 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCM04607.1 - 4.6e-07 30.3 6.8 0.24 11.9 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat tRNA_anti-codon PF01336.25 CCM04607.1 - 1.4e-06 28.2 0.1 2.8e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 CCM04607.1 - 0.00028 20.7 0.0 0.00063 19.6 0.0 1.5 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 CIDE-N PF02017.15 CCM04607.1 - 0.0068 16.4 0.1 0.024 14.7 0.0 2.0 2 0 0 2 2 2 1 CIDE-N domain BTAD PF03704.17 CCM04607.1 - 0.017 15.5 0.1 0.017 15.5 0.1 3.3 3 1 1 4 4 4 0 Bacterial transcriptional activator domain GRP PF07172.11 CCM04607.1 - 0.041 14.6 12.4 0.075 13.7 12.4 1.4 1 0 0 1 1 1 0 Glycine rich protein family FAD-oxidase_C PF02913.19 CCM04608.1 - 2.2e-57 194.6 0.0 3.2e-57 194.0 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CCM04608.1 - 1e-13 51.2 0.0 2.3e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain tRNA_anti-codon PF01336.25 CCM04609.1 - 0.0045 16.9 0.1 0.0085 16.1 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Lipase_GDSL_2 PF13472.6 CCM04610.1 - 1.7e-07 31.8 0.9 3.3e-07 30.9 0.9 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCM04610.1 - 2.1e-05 24.6 0.0 3.3e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Ribosomal_L24e PF01246.20 CCM04611.1 - 3.1e-32 110.6 6.7 3.1e-32 110.6 6.7 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e HAGH_C PF16123.5 CCM04611.1 - 0.032 14.7 1.4 0.052 14.1 0.7 1.8 1 1 1 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus zf-FCS PF06467.14 CCM04611.1 - 0.067 13.1 4.3 0.12 12.3 4.3 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif SH2_2 PF14633.6 CCM04612.1 - 2.3e-78 262.5 0.2 2.3e-78 262.5 0.2 2.0 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 CCM04612.1 - 4.3e-29 100.9 0.0 8.6e-29 99.9 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 CCM04612.1 - 5.4e-29 100.9 0.0 1.3e-28 99.6 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 CCM04612.1 - 8.1e-29 100.4 0.0 2e-28 99.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 CCM04612.1 - 4.9e-20 71.9 30.1 4.9e-20 71.9 30.1 5.9 5 1 2 7 7 7 1 Acidic N-terminal SPT6 SH2 PF00017.24 CCM04612.1 - 4.2e-08 33.2 0.0 9.3e-06 25.7 0.0 2.9 3 0 0 3 3 3 1 SH2 domain HHH_9 PF17674.1 CCM04612.1 - 1.3e-06 29.2 0.5 8.4e-06 26.6 0.5 2.6 1 0 0 1 1 1 1 HHH domain S1 PF00575.23 CCM04612.1 - 0.0035 17.6 0.2 0.0083 16.4 0.2 1.6 1 0 0 1 1 1 1 S1 RNA binding domain HHH_3 PF12836.7 CCM04612.1 - 0.0044 17.3 0.0 0.015 15.5 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif WD40 PF00400.32 CCM04614.1 - 2.7e-13 50.1 11.8 0.012 16.4 0.0 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04614.1 - 0.00062 20.0 0.0 4.6 7.6 0.0 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SRP54 PF00448.22 CCM04615.1 - 4.1e-74 248.5 0.8 6.2e-74 247.9 0.8 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 CCM04615.1 - 1.3e-19 70.2 3.0 2.7e-19 69.2 3.0 1.6 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 CCM04615.1 - 3.3e-05 23.5 0.2 8.8e-05 22.2 0.2 1.7 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CCM04615.1 - 9.9e-05 22.5 0.0 0.0002 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CCM04615.1 - 0.00079 18.8 0.1 0.0015 17.9 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin CbiA PF01656.23 CCM04615.1 - 0.00081 19.4 0.0 0.0033 17.5 0.0 2.2 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 CCM04615.1 - 0.0011 18.0 0.1 0.0028 16.7 0.1 1.7 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 CCM04615.1 - 0.0015 19.0 0.6 0.0034 17.8 0.1 1.9 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 CCM04615.1 - 0.0094 15.7 1.1 0.024 14.4 0.2 2.1 2 0 0 2 2 2 1 AAA domain Fe-ADH PF00465.19 CCM04615.1 - 0.011 14.6 0.0 0.021 13.6 0.0 1.5 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase ResIII PF04851.15 CCM04615.1 - 0.03 14.3 0.4 2.1 8.3 0.1 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit MipZ PF09140.11 CCM04615.1 - 0.049 12.9 0.1 1.9 7.7 0.1 2.3 1 1 0 1 1 1 0 ATPase MipZ AAA_31 PF13614.6 CCM04615.1 - 0.054 13.4 0.3 0.46 10.4 0.1 2.1 1 1 1 2 2 2 0 AAA domain 6PF2K PF01591.18 CCM04615.1 - 0.055 12.8 0.0 0.085 12.1 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase DUF2201 PF09967.9 CCM04615.1 - 0.081 13.1 0.3 0.83 9.8 0.1 2.2 2 0 0 2 2 2 0 VWA-like domain (DUF2201) CLP1_P PF16575.5 CCM04615.1 - 0.095 12.5 0.4 4.3 7.1 0.0 2.5 1 1 1 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 CCM04615.1 - 0.12 12.7 0.1 0.54 10.6 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain NTPase_1 PF03266.15 CCM04615.1 - 0.17 11.8 2.0 7.9 6.4 2.0 2.6 1 1 0 1 1 1 0 NTPase ArsA_ATPase PF02374.15 CCM04615.1 - 0.27 10.4 3.4 16 4.5 0.7 3.1 2 1 0 2 2 2 0 Anion-transporting ATPase SRP_SPB PF02978.19 CCM04616.1 - 1.1e-19 70.9 0.1 1.1e-19 70.9 0.1 3.3 2 1 1 3 3 3 1 Signal peptide binding domain Snf7 PF03357.21 CCM04616.1 - 0.14 11.8 6.3 0.26 10.9 6.3 1.4 1 0 0 1 1 1 0 Snf7 RRM_1 PF00076.22 CCM04617.1 - 1.9e-82 271.1 3.5 2.9e-20 71.8 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CCM04617.1 - 4.1e-26 91.0 1.9 7.5e-26 90.1 1.0 2.0 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_7 PF16367.5 CCM04617.1 - 4.5e-05 23.5 0.2 2.6 8.2 0.0 4.6 4 1 0 4 4 4 1 RNA recognition motif RRM_3 PF08777.11 CCM04617.1 - 0.00018 21.5 7.0 0.26 11.4 1.5 3.7 4 0 0 4 4 4 2 RNA binding motif Nup35_RRM_2 PF14605.6 CCM04617.1 - 0.00077 19.4 1.2 3.8 7.6 0.0 4.0 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 CCM04617.1 - 0.014 15.1 1.6 21 4.9 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain RRM_occluded PF16842.5 CCM04617.1 - 0.017 15.0 0.0 4.8 7.1 0.0 2.9 3 0 0 3 3 3 0 Occluded RNA-recognition motif ArAE_1_C PF11728.8 CCM04617.1 - 0.046 13.7 1.9 0.13 12.2 0.1 2.3 2 0 0 2 2 2 0 Putative aromatic acid exporter C-terminal domain DUF4407 PF14362.6 CCM04617.1 - 0.26 10.6 2.9 0.19 11.1 1.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Nefa_Nip30_N PF10187.9 CCM04617.1 - 6.9 7.1 12.8 0.24 11.8 0.2 2.6 3 0 0 3 3 3 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 SCAMP PF04144.13 CCM04618.1 - 4.1e-52 177.0 4.4 4.8e-52 176.8 4.4 1.0 1 0 0 1 1 1 1 SCAMP family DUF3552 PF12072.8 CCM04618.1 - 0.3 10.5 1.8 0.48 9.8 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Isochorismatase PF00857.20 CCM04619.1 - 5.9e-18 65.6 0.0 1.3e-17 64.5 0.0 1.6 1 1 0 1 1 1 1 Isochorismatase family Sde2_N_Ubi PF13019.6 CCM04619.1 - 0.21 11.4 0.2 0.33 10.8 0.2 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain ADK PF00406.22 CCM04620.1 - 5.6e-44 149.9 0.0 9.5e-44 149.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCM04620.1 - 6.1e-19 68.8 0.0 1.3e-18 67.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 CCM04620.1 - 9.9e-14 51.0 0.0 2e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 CCM04620.1 - 9.2e-06 26.2 0.0 2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain Epimerase PF01370.21 CCM04620.1 - 5.8e-05 22.7 0.0 0.00034 20.2 0.0 2.1 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family AAA_33 PF13671.6 CCM04620.1 - 0.00014 22.1 0.4 0.0005 20.3 0.0 2.1 3 1 0 3 3 3 1 AAA domain NAD_binding_10 PF13460.6 CCM04620.1 - 0.0046 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding Ploopntkinase3 PF18751.1 CCM04620.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 3Beta_HSD PF01073.19 CCM04620.1 - 0.2 10.6 0.0 0.48 9.4 0.0 1.6 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_PK PF05891.12 CCM04621.1 - 2e-34 119.0 0.0 1.1e-32 113.3 0.0 2.5 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 CCM04621.1 - 0.00055 20.6 0.1 0.13 13.0 0.1 2.3 1 1 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CCM04621.1 - 0.0029 17.5 0.0 0.0036 17.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04621.1 - 0.0042 17.7 0.1 0.11 13.2 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Swi3 PF07962.12 CCM04622.1 - 5.7e-31 106.4 0.1 9e-31 105.7 0.1 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Put_DNA-bind_N PF06971.13 CCM04623.1 - 0.092 12.8 0.1 0.26 11.3 0.1 1.8 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus Spc7 PF08317.11 CCM04624.1 - 0.026 13.4 21.0 0.044 12.7 21.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.11 CCM04624.1 - 0.094 12.9 25.1 0.83 9.8 24.8 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Phage_lysis PF03245.13 CCM04624.1 - 0.15 12.2 11.7 0.18 11.9 9.9 2.2 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein DUF3450 PF11932.8 CCM04624.1 - 0.16 11.3 19.7 0.023 14.0 12.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Golgin_A5 PF09787.9 CCM04624.1 - 0.33 10.4 19.2 0.52 9.7 19.2 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 LMBR1 PF04791.16 CCM04624.1 - 0.56 9.1 6.3 0.85 8.4 6.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.9 CCM04624.1 - 0.8 8.7 16.6 1.5 7.8 16.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 CCM04624.1 - 0.83 8.2 10.5 1.1 7.7 10.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Fes1 PF08609.10 CCM04624.1 - 1.4 9.9 6.7 1.4 9.8 4.3 2.2 1 1 1 2 2 2 0 Nucleotide exchange factor Fes1 DUF4618 PF15397.6 CCM04624.1 - 2.1 7.7 19.8 0.43 10.0 15.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Lebercilin PF15619.6 CCM04624.1 - 3.6 7.2 27.7 0.7 9.5 15.0 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Prominin PF05478.11 CCM04624.1 - 4.3 5.2 12.8 1.9 6.3 10.0 1.6 1 1 0 1 1 1 0 Prominin Myb_DNA-bind_4 PF13837.6 CCM04624.1 - 4.4 7.8 12.1 5.4 7.5 8.3 3.0 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain Bap31_Bap29_C PF18035.1 CCM04624.1 - 4.9 7.2 15.2 4.8 7.3 5.9 2.9 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain zf-C4H2 PF10146.9 CCM04624.1 - 5.7 7.2 17.5 15 5.8 17.5 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein CSN5_C PF18323.1 CCM04624.1 - 6.1 7.8 12.1 21 6.1 12.1 2.0 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain Exonuc_VII_L PF02601.15 CCM04624.1 - 6.2 6.3 14.7 10 5.6 14.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FlxA PF14282.6 CCM04624.1 - 8.4 6.5 21.5 0.78 9.8 0.2 3.2 1 1 2 3 3 3 0 FlxA-like protein CdvA PF18822.1 CCM04624.1 - 10 6.0 16.8 67 3.3 14.1 2.9 2 1 1 3 3 2 0 CdvA-like coiled-coil domain HSP70 PF00012.20 CCM04625.1 - 0.16 10.2 0.1 1 7.5 0.0 2.1 2 1 0 2 2 2 0 Hsp70 protein Epimerase PF01370.21 CCM04626.1 - 5.9e-15 55.4 0.0 9.1e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM04626.1 - 1e-06 28.8 0.3 1.5e-06 28.2 0.3 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCM04626.1 - 2.9e-06 26.9 0.1 2.9e-06 26.9 0.1 1.4 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCM04626.1 - 7.9e-06 25.6 2.1 1.4e-05 24.8 2.1 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 CCM04626.1 - 0.00041 19.6 0.1 0.011 14.9 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 CCM04626.1 - 0.0023 17.0 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 CCM04626.1 - 0.011 15.2 0.3 0.068 12.6 0.4 2.0 2 0 0 2 2 2 0 short chain dehydrogenase SlyX PF04102.12 CCM04627.1 - 0.018 15.6 3.4 0.018 15.6 3.4 2.4 1 1 1 2 2 2 0 SlyX SPATA24 PF15175.6 CCM04627.1 - 0.057 13.3 2.5 0.11 12.4 2.5 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 RNase_T PF00929.24 CCM04629.1 - 1.4e-13 51.7 0.0 2.1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 CCM04629.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 1 0 1 1 1 1 3'-5' exonuclease Mito_carr PF00153.27 CCM04630.1 - 2.7e-55 184.3 2.4 6.4e-20 70.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Colicin_V PF02674.16 CCM04630.1 - 4.9 7.1 6.5 16 5.4 0.3 2.8 3 0 0 3 3 3 0 Colicin V production protein DUF4050 PF13259.6 CCM04632.1 - 0.011 16.0 2.7 0.018 15.4 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) GST_C_4 PF14834.6 CCM04633.1 - 0.026 14.9 0.9 0.068 13.6 0.3 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Cornichon PF03311.14 CCM04634.1 - 2.1e-45 154.0 2.2 2.3e-45 153.8 2.2 1.0 1 0 0 1 1 1 1 Cornichon protein RRM_1 PF00076.22 CCM04636.1 - 1.4e-08 34.4 0.0 2.6e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCM04636.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PSI_PsaJ PF01701.18 CCM04637.1 - 1.1 9.9 4.2 5.2 7.7 4.2 2.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ Glyco_transf_49 PF13896.6 CCM04638.1 - 1.7e-67 228.2 0.0 3.9e-67 226.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan Cupin_2 PF07883.11 CCM04638.1 - 2e-05 24.2 0.0 5.6e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 CCM04638.1 - 2.8e-05 23.8 0.0 5.9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.7 CCM04638.1 - 0.00027 20.7 0.0 0.00056 19.7 0.0 1.5 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 CCM04638.1 - 0.0004 20.3 0.1 0.00083 19.3 0.1 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain DUF4632 PF15451.6 CCM04638.1 - 0.27 11.3 0.6 0.66 10.1 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) Methyltransf_25 PF13649.6 CCM04639.1 - 6.3e-10 39.6 0.0 1.1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04639.1 - 4.3e-06 27.3 0.0 7.5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM04639.1 - 3.4e-05 23.3 0.0 5.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CCM04639.1 - 3.7e-05 23.6 0.0 0.00011 22.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM04639.1 - 5.6e-05 23.0 0.0 8.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM04639.1 - 0.022 15.5 0.0 0.037 14.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CCM04639.1 - 0.056 13.2 0.0 0.071 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GCD14 PF08704.10 CCM04639.1 - 0.15 11.7 0.0 0.61 9.7 0.0 1.8 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit adh_short PF00106.25 CCM04640.1 - 4.1e-31 108.0 0.0 6.1e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04640.1 - 1.1e-20 74.2 0.0 1.6e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCM04640.1 - 0.00015 21.7 0.0 0.00024 21.1 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Methyltransf_2 PF00891.18 CCM04641.1 - 2.7e-20 72.6 0.0 1e-19 70.7 0.0 1.8 1 1 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CCM04641.1 - 0.00017 21.5 0.0 0.0004 20.3 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_31 PF13847.6 CCM04641.1 - 0.0012 18.7 0.0 0.0093 15.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCM04641.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain ABC_tran_CTD PF16326.5 CCM04641.1 - 0.072 13.3 0.1 0.13 12.6 0.1 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain MFS_1 PF07690.16 CCM04642.1 - 1.8e-28 99.5 30.8 2.3e-25 89.3 21.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 CCM04643.1 - 1.5e-49 167.8 0.0 2.1e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM04643.1 - 3.9e-18 65.4 0.0 4.4e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCM04643.1 - 3.4e-07 30.6 0.0 5.3e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CCM04643.1 - 0.00065 19.3 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 CCM04643.1 - 0.094 13.2 0.0 0.22 12.1 0.0 1.6 1 1 0 1 1 1 0 XdhC Rossmann domain DUF374 PF04028.13 CCM04643.1 - 0.14 11.7 0.0 0.38 10.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF374) AlaDh_PNT_C PF01262.21 CCM04643.1 - 0.14 11.4 0.1 0.32 10.3 0.1 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCM04644.1 - 2.1e-50 170.5 0.0 3e-50 170.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM04644.1 - 3.8e-17 62.2 0.0 4.8e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCM04644.1 - 1.9e-05 24.9 0.0 4.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CCM04644.1 - 0.0064 16.1 0.0 0.0091 15.6 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 CCM04644.1 - 0.023 14.0 0.0 0.042 13.1 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF2367 PF10164.9 CCM04645.1 - 0.1 13.1 10.1 0.66 10.5 10.1 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) MFS_1 PF07690.16 CCM04646.1 - 9.8e-38 130.0 23.5 9.8e-38 130.0 23.5 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 CCM04647.1 - 6.1e-51 172.3 0.0 8.8e-51 171.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM04647.1 - 2.3e-16 59.6 0.0 3.1e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCM04647.1 - 3.5e-05 24.0 0.0 5.8e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 CCM04647.1 - 0.0069 15.7 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 CCM04647.1 - 0.13 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF2263 PF10021.9 CCM04648.1 - 1.9e-26 93.2 0.0 3.5e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Peptidase_M20 PF01546.28 CCM04649.1 - 6.2e-26 91.4 0.0 1.7e-25 90.0 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM04649.1 - 5.7e-09 35.9 0.1 1.5e-08 34.5 0.1 1.8 1 1 0 1 1 1 1 Peptidase dimerisation domain 2-Hacid_dh_C PF02826.19 CCM04652.1 - 1.3e-51 174.5 0.0 1.8e-51 174.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM04652.1 - 6.9e-14 51.7 0.0 9.1e-14 51.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCM04652.1 - 0.00077 19.7 0.0 0.0012 19.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CCM04652.1 - 0.0019 17.8 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 CCM04652.1 - 0.097 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain MFS_1 PF07690.16 CCM04654.1 - 5.1e-14 52.0 54.2 7e-11 41.6 32.4 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily p450 PF00067.22 CCM04655.1 - 1.9e-73 247.8 0.0 3.7e-73 246.9 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 CCM04656.1 - 1e-48 166.2 0.0 7.6e-48 163.3 0.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCM04656.1 - 1e-40 140.2 0.0 1.8e-40 139.4 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain NAD_binding_4 PF07993.12 CCM04656.1 - 1.7e-32 112.6 0.0 2.6e-32 112.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein KR PF08659.10 CCM04656.1 - 4e-32 111.6 1.1 2.2e-27 96.1 0.3 2.7 2 0 0 2 2 2 2 KR domain PS-DH PF14765.6 CCM04656.1 - 7.9e-29 100.8 0.0 2e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CCM04656.1 - 7.9e-26 90.4 0.0 1.6e-25 89.4 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CCM04656.1 - 5.1e-10 39.8 0.0 2.6e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 CCM04656.1 - 1.6e-07 31.0 0.0 3.8e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM04656.1 - 8.3e-07 29.3 0.1 2.3e-06 27.8 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site GDP_Man_Dehyd PF16363.5 CCM04656.1 - 0.00099 18.6 0.3 0.0024 17.3 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Thiolase_N PF00108.23 CCM04656.1 - 0.0014 18.0 0.1 0.0098 15.3 0.1 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain adh_short PF00106.25 CCM04656.1 - 0.0019 17.7 0.1 0.027 13.9 0.1 2.9 4 0 0 4 4 4 1 short chain dehydrogenase ACP_syn_III PF08545.10 CCM04656.1 - 0.011 15.6 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Polysacc_synt_2 PF02719.15 CCM04656.1 - 0.023 13.9 0.1 0.15 11.2 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein PTCB-BRCT PF12738.7 CCM04659.1 - 7.2e-11 41.9 0.0 5.5e-10 39.1 0.0 2.1 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 CCM04659.1 - 1.1e-07 32.1 0.0 4.3e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CCM04659.1 - 0.0042 17.3 0.0 2.8 8.3 0.0 2.2 1 1 1 2 2 2 2 DNA ligase 3 BRCT domain WGR PF05406.15 CCM04660.1 - 2.3e-13 50.0 0.6 4.2e-13 49.2 0.6 1.4 1 0 0 1 1 1 1 WGR domain DUF3810 PF12725.7 CCM04663.1 - 4.2 6.6 6.5 1.9 7.8 3.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) PTCB-BRCT PF12738.7 CCM04664.1 - 2.8e-27 94.5 0.0 4.4e-13 49.0 0.0 3.8 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 CCM04664.1 - 2.1e-23 82.5 0.1 3.1e-09 37.1 0.0 5.0 4 1 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CCM04664.1 - 5.8e-07 29.8 0.0 0.95 9.9 0.0 4.2 4 0 0 4 4 4 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CCM04664.1 - 0.062 13.6 0.0 94 3.4 0.0 3.5 3 0 0 3 3 3 0 DNA ligase 3 BRCT domain NIBRIN_BRCT_II PF16508.5 CCM04664.1 - 0.16 12.3 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 Second BRCT domain on Nijmegen syndrome breakage protein DUF4139 PF13598.6 CCM04665.1 - 1.2e-24 87.2 0.0 2.9e-24 86.0 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 CCM04665.1 - 1.9e-09 37.9 0.9 1.9e-09 37.9 0.9 3.2 3 1 0 3 3 3 1 N-terminal domain of unknown function (DUF4140) DUF3748 PF12566.8 CCM04666.1 - 0.19 11.7 0.0 6.3 6.8 0.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3748) Epimerase PF01370.21 CCM04668.1 - 1.2e-12 47.8 0.0 9.6e-12 44.9 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM04668.1 - 4.2e-09 36.6 0.1 8.1e-09 35.6 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CCM04668.1 - 0.00051 19.2 0.0 0.095 11.8 0.0 2.4 2 0 0 2 2 2 2 RmlD substrate binding domain UDPG_MGDP_dh_N PF03721.14 CCM04668.1 - 0.0006 19.4 0.0 0.00095 18.8 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NmrA PF05368.13 CCM04668.1 - 0.00061 19.4 0.1 0.00086 18.9 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCM04668.1 - 0.00068 19.1 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_2 PF03446.15 CCM04668.1 - 0.0051 17.0 0.0 0.0093 16.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CCM04668.1 - 0.006 16.5 0.4 0.011 15.6 0.1 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CCM04668.1 - 0.011 14.7 0.0 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Pyr_redox PF00070.27 CCM04668.1 - 0.025 15.1 0.2 0.046 14.3 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Rossmann-like PF10727.9 CCM04668.1 - 0.026 14.4 0.3 0.054 13.4 0.3 1.6 1 0 0 1 1 1 0 Rossmann-like domain TrkA_N PF02254.18 CCM04668.1 - 0.036 14.3 0.0 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain GDP_Man_Dehyd PF16363.5 CCM04668.1 - 0.043 13.2 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 CCM04668.1 - 0.086 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Fibrillarin PF01269.17 CCM04668.1 - 0.15 11.2 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin MFS_1 PF07690.16 CCM04669.1 - 2.4e-24 85.9 16.2 2.5e-16 59.6 11.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily VPS13 PF16908.5 CCM04671.1 - 9e-08 32.2 0.3 9e-08 32.2 0.3 1.8 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal DUF1664 PF07889.12 CCM04671.1 - 0.037 14.1 5.0 0.042 13.9 0.3 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) XhlA PF10779.9 CCM04671.1 - 0.18 12.0 0.3 1.4 9.2 0.0 2.7 2 0 0 2 2 2 0 Haemolysin XhlA TRPM_tetra PF16519.5 CCM04671.1 - 0.3 11.2 1.9 1.6 8.8 0.1 2.9 3 0 0 3 3 3 0 Tetramerisation domain of TRPM MscS_porin PF12795.7 CCM04671.1 - 0.88 9.1 7.0 0.4 10.2 0.1 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain AAA PF00004.29 CCM04672.1 - 3.8e-93 308.9 0.0 8.7e-47 158.9 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCM04672.1 - 7.4e-22 76.9 2.3 1.3e-10 40.9 0.9 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 CCM04672.1 - 1.2e-15 57.6 0.0 3.2e-08 33.5 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CCM04672.1 - 4.3e-12 46.8 3.5 0.0011 19.4 0.1 4.6 3 2 1 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 CCM04672.1 - 5.6e-12 46.1 0.5 0.015 15.6 0.1 5.1 2 2 1 4 4 4 2 AAA domain AAA_5 PF07728.14 CCM04672.1 - 2.3e-10 40.6 0.4 0.0017 18.3 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CCM04672.1 - 5.2e-10 39.6 0.0 0.00016 21.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 CCM04672.1 - 8.3e-10 39.0 0.0 0.001 19.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 CCM04672.1 - 5.3e-09 35.7 0.0 7.5e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 CCM04672.1 - 6.5e-08 32.9 0.0 0.021 15.2 0.0 2.8 2 1 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 CCM04672.1 - 7.3e-08 32.5 0.0 0.0099 15.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CCM04672.1 - 3.3e-07 30.2 0.0 0.021 14.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 CCM04672.1 - 4.6e-07 29.4 0.2 0.033 13.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CCM04672.1 - 1.1e-06 29.0 0.0 0.029 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 CCM04672.1 - 4.5e-06 26.6 0.0 0.011 15.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CCM04672.1 - 5.3e-06 26.5 0.4 0.096 12.6 0.0 3.5 3 1 0 3 3 2 2 NACHT domain ABC_tran PF00005.27 CCM04672.1 - 6e-06 26.8 0.0 0.11 13.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter TsaE PF02367.17 CCM04672.1 - 6.2e-06 26.2 0.0 0.082 12.9 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CCM04672.1 - 2.1e-05 25.1 0.0 0.33 11.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain Cytidylate_kin2 PF13189.6 CCM04672.1 - 2.6e-05 24.4 0.0 0.015 15.4 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family Vps4_C PF09336.10 CCM04672.1 - 3.1e-05 23.9 0.1 0.029 14.4 0.0 2.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ATPase PF06745.13 CCM04672.1 - 3.2e-05 23.4 0.0 0.72 9.2 0.0 3.2 2 1 0 3 3 3 2 KaiC Rad17 PF03215.15 CCM04672.1 - 3.3e-05 23.9 0.0 0.11 12.4 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain Zeta_toxin PF06414.12 CCM04672.1 - 6.1e-05 22.4 0.0 0.37 10.1 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.6 CCM04672.1 - 6.6e-05 22.6 0.8 2.4 7.7 0.0 4.0 3 1 1 4 4 4 2 AAA domain Sigma54_activat PF00158.26 CCM04672.1 - 8.1e-05 22.4 0.0 0.45 10.2 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.6 CCM04672.1 - 8.5e-05 23.0 0.0 0.13 12.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CCM04672.1 - 0.00011 21.8 0.0 0.66 9.5 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region DUF815 PF05673.13 CCM04672.1 - 0.00025 20.3 0.0 0.011 14.9 0.0 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 CCM04672.1 - 0.00037 20.6 0.0 1.3 9.1 0.0 2.9 3 0 0 3 3 3 2 Sigma-54 interaction domain Viral_helicase1 PF01443.18 CCM04672.1 - 0.00046 20.0 0.0 0.66 9.7 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 CCM04672.1 - 0.00048 19.4 0.0 0.95 8.6 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_11 PF13086.6 CCM04672.1 - 0.0013 18.6 0.0 2 8.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 CCM04672.1 - 0.0015 17.7 0.1 1.5 7.8 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 SKI PF01202.22 CCM04672.1 - 0.002 18.3 0.0 2.2 8.4 0.0 2.7 2 0 0 2 2 2 1 Shikimate kinase ATPase_2 PF01637.18 CCM04672.1 - 0.0024 17.8 0.0 2 8.2 0.0 2.9 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea PhoH PF02562.16 CCM04672.1 - 0.0033 16.9 0.1 2.3 7.6 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_24 PF13479.6 CCM04672.1 - 0.0035 17.1 0.0 0.98 9.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 CCM04672.1 - 0.018 14.9 0.0 4.9 6.9 0.0 2.5 2 1 0 2 2 2 0 Bacterial dnaA protein DUF2075 PF09848.9 CCM04672.1 - 0.025 13.8 0.0 2.1 7.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AFG1_ATPase PF03969.16 CCM04672.1 - 0.025 13.5 0.0 1.5 7.6 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase NTPase_1 PF03266.15 CCM04672.1 - 0.029 14.3 0.0 6.8 6.6 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 CCM04672.1 - 0.047 14.0 0.9 20 5.5 0.2 3.0 2 1 0 2 2 2 0 AAA domain CPT PF07931.12 CCM04672.1 - 0.058 13.2 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.9 CCM04672.1 - 0.059 13.1 0.0 11 5.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 CCM04672.1 - 0.22 11.6 0.1 15 5.7 0.0 3.1 2 1 1 3 3 3 0 50S ribosome-binding GTPase Abhydrolase_6 PF12697.7 CCM04673.1 - 1.2e-24 88.1 0.4 1.2e-24 88.1 0.4 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCM04673.1 - 5.9e-10 39.2 0.0 1.2e-09 38.2 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM04673.1 - 4.9e-08 32.5 0.0 8.6e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CCM04673.1 - 0.0012 19.0 0.0 0.0022 18.1 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain LIDHydrolase PF10230.9 CCM04673.1 - 0.067 12.7 0.0 0.31 10.5 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Epimerase PF01370.21 CCM04674.1 - 1.3e-11 44.4 0.0 2.1e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM04674.1 - 6.2e-09 36.0 0.1 9.1e-09 35.5 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CCM04674.1 - 0.00038 20.0 0.2 0.00057 19.4 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 CCM04674.1 - 0.00098 18.7 0.1 0.0013 18.4 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CCM04674.1 - 0.0028 17.1 0.1 0.4 10.0 0.0 2.4 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase UDPG_MGDP_dh_N PF03721.14 CCM04674.1 - 0.0048 16.5 0.1 0.0075 15.9 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Rossmann-like PF10727.9 CCM04674.1 - 0.005 16.7 0.4 0.013 15.3 0.5 1.7 2 0 0 2 2 2 1 Rossmann-like domain NAD_binding_2 PF03446.15 CCM04674.1 - 0.0051 17.0 0.0 0.0084 16.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Fibrillarin PF01269.17 CCM04674.1 - 0.035 13.2 0.0 0.052 12.7 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin RmlD_sub_bind PF04321.17 CCM04674.1 - 0.092 11.8 0.1 0.36 9.9 0.1 2.0 1 1 0 1 1 1 0 RmlD substrate binding domain 3Beta_HSD PF01073.19 CCM04674.1 - 0.15 11.0 0.0 5.1 6.0 0.0 2.2 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family p450 PF00067.22 CCM04675.1 - 2.7e-70 237.4 0.0 2e-69 234.5 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 APH PF01636.23 CCM04676.1 - 2.9e-10 40.5 0.5 8e-10 39.0 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family VPS13 PF16908.5 CCM04676.1 - 6.2e-05 22.9 0.1 0.00016 21.5 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal Rubrerythrin PF02915.17 CCM04677.1 - 0.0054 17.1 0.6 0.011 16.1 0.6 1.4 1 0 0 1 1 1 1 Rubrerythrin TMEM154 PF15102.6 CCM04677.1 - 0.013 15.4 0.1 0.013 15.4 0.1 2.5 3 0 0 3 3 3 0 TMEM154 protein family Mid2 PF04478.12 CCM04677.1 - 0.049 13.5 0.7 0.13 12.1 0.7 1.7 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF202 PF02656.15 CCM04677.1 - 0.18 12.3 0.7 0.39 11.2 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) BAR_3 PF16746.5 CCM04677.1 - 0.21 11.3 1.0 0.34 10.6 1.0 1.2 1 0 0 1 1 1 0 BAR domain of APPL family p450 PF00067.22 CCM04678.1 - 1.2e-67 228.7 0.0 1.5e-67 228.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 YchF-GTPase_C PF06071.13 CCM04679.1 - 3.3e-35 120.1 0.0 1.2e-34 118.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CCM04679.1 - 3.6e-13 49.6 0.0 1.5e-12 47.6 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCM04679.1 - 0.0088 15.6 0.3 0.017 14.6 0.3 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RPAP1_N PF08621.10 CCM04679.1 - 0.0092 15.7 1.9 0.017 14.9 1.9 1.4 1 0 0 1 1 1 1 RPAP1-like, N-terminal IIGP PF05049.13 CCM04679.1 - 0.09 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF3446 PF11928.8 CCM04680.1 - 1.7 9.0 9.0 0.25 11.7 4.7 1.7 2 0 0 2 2 2 0 Early growth response N-terminal domain Med25_VWA PF11265.8 CCM04681.1 - 1e-05 25.5 0.0 2.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A ANAPC4_WD40 PF12894.7 CCM04682.1 - 0.068 13.5 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain FapA PF03961.13 CCM04682.1 - 0.11 11.1 0.6 0.17 10.5 0.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 CCM04682.1 - 0.68 9.2 7.1 0.75 9.1 6.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FliJ PF02050.16 CCM04682.1 - 1.7 8.9 4.9 0.71 10.1 1.7 1.9 2 0 0 2 2 2 0 Flagellar FliJ protein PITH PF06201.13 CCM04683.1 - 2.6e-37 128.4 0.0 3.2e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 PITH domain UBX PF00789.20 CCM04684.1 - 1.6e-07 31.4 1.7 4.8e-07 29.9 1.7 1.7 1 1 0 1 1 1 1 UBX domain Pro_isomerase PF00160.21 CCM04685.1 - 2.5e-43 148.1 0.0 2.5e-43 148.1 0.0 1.7 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GREB1 PF15782.5 CCM04685.1 - 1.4 6.0 9.1 1.7 5.6 9.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DEAD PF00270.29 CCM04686.1 - 6.2e-53 179.2 0.0 8.7e-52 175.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Ras PF00071.22 CCM04686.1 - 4.4e-40 136.9 0.1 1.6e-39 135.1 0.0 1.8 2 0 0 2 2 2 1 Ras family Helicase_C PF00271.31 CCM04686.1 - 1.8e-32 112.0 0.0 3.6e-31 107.8 0.0 2.6 2 1 1 3 3 3 1 Helicase conserved C-terminal domain Roc PF08477.13 CCM04686.1 - 1.4e-11 44.6 0.0 6.1e-11 42.6 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 CCM04686.1 - 3.2e-07 30.5 0.0 1e-06 28.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit GTP_EFTU PF00009.27 CCM04686.1 - 7.2e-06 25.7 0.0 2.2e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM04686.1 - 0.0031 17.4 0.1 0.11 12.4 0.0 2.8 1 1 1 2 2 2 1 RsgA GTPase UTP25 PF06862.12 CCM04686.1 - 0.02 13.7 0.0 0.17 10.6 0.0 2.3 2 1 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF2313 PF10076.9 CCM04686.1 - 0.066 13.1 0.1 0.16 11.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2313) DUF2443 PF10398.9 CCM04686.1 - 0.11 12.5 0.5 0.22 11.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) GRP PF07172.11 CCM04686.1 - 0.77 10.5 69.8 4.7 8.0 29.3 2.6 2 0 0 2 2 2 0 Glycine rich protein family Abhydrolase_6 PF12697.7 CCM04687.1 - 4.1e-06 27.6 0.0 0.00015 22.5 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family PhoPQ_related PF10142.9 CCM04687.1 - 0.00067 18.4 0.0 0.0026 16.5 0.0 1.8 1 1 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Peptidase_S9 PF00326.21 CCM04687.1 - 0.0026 17.2 0.0 0.01 15.4 0.0 2.0 2 1 0 2 2 2 1 Prolyl oligopeptidase family Esterase PF00756.20 CCM04687.1 - 0.0043 16.7 0.0 0.0082 15.8 0.0 1.6 1 1 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 CCM04687.1 - 0.0053 16.0 0.0 0.17 11.1 0.0 2.6 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Alba PF01918.21 CCM04689.1 - 0.00071 19.3 0.0 0.17 11.8 0.0 2.7 2 1 0 2 2 2 2 Alba PHD PF00628.29 CCM04690.1 - 6.9e-09 35.5 7.2 1.3e-08 34.6 7.2 1.5 1 0 0 1 1 1 1 PHD-finger WSD PF15613.6 CCM04690.1 - 0.35 11.4 6.5 0.6 10.6 0.1 3.3 2 1 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif ANAPC10 PF03256.16 CCM04691.1 - 5.7e-49 166.3 0.0 6.8e-49 166.0 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 CCM04691.1 - 0.063 13.4 0.0 0.13 12.4 0.0 1.5 1 1 0 1 1 1 0 F5/8 type C domain ThiF PF00899.21 CCM04692.1 - 7.2e-62 208.9 0.0 1.1e-61 208.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 CCM04692.1 - 0.00091 19.3 0.7 0.01 15.9 0.2 2.4 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase Rhodanese PF00581.20 CCM04692.1 - 0.0078 16.7 0.0 0.023 15.2 0.0 1.9 1 0 0 1 1 1 1 Rhodanese-like domain UDPG_MGDP_dh_N PF03721.14 CCM04692.1 - 0.012 15.3 0.1 0.018 14.6 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 CCM04692.1 - 0.15 12.5 0.1 0.49 10.9 0.1 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding zf-Tim10_DDP PF02953.15 CCM04693.1 - 4.7e-24 83.8 2.1 5.6e-24 83.6 2.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Cytomega_TRL10 PF06084.11 CCM04693.1 - 0.014 15.4 0.9 0.018 15.0 0.9 1.1 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein DnaJ PF00226.31 CCM04694.1 - 5.1e-23 81.0 0.9 1.4e-22 79.6 0.9 1.8 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 CCM04694.1 - 1.6e-11 44.2 1.4 7.7e-08 32.4 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CCM04694.1 - 5.5e-11 42.5 4.7 1.6e-07 31.5 0.3 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CCM04694.1 - 1.7e-07 31.5 0.6 0.017 15.4 0.0 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCM04694.1 - 3.2e-05 24.4 2.9 0.12 13.2 0.3 3.1 2 1 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CCM04694.1 - 6.4e-05 23.2 3.4 0.05 14.1 0.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CCM04694.1 - 0.0039 17.2 3.4 0.16 12.0 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger Actin_micro PF17003.5 CCM04694.1 - 0.23 10.6 0.1 2.3 7.3 0.0 2.0 2 0 0 2 2 2 0 Putative actin-like family VATC PF18716.1 CCM04694.1 - 0.24 11.3 1.0 6.5 6.7 0.1 2.3 2 0 0 2 2 2 0 Vms1-associating treble clef domain Prp18 PF02840.15 CCM04695.1 - 4e-57 192.3 0.0 4e-57 192.3 0.0 2.6 3 0 0 3 3 3 1 Prp18 domain PRP4 PF08799.11 CCM04695.1 - 8.2e-10 38.1 6.8 2.7e-09 36.4 6.8 2.0 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like NEMP PF10225.9 CCM04695.1 - 0.66 9.6 1.7 1.2 8.8 1.7 1.4 1 0 0 1 1 1 0 NEMP family Pinin_SDK_memA PF04696.13 CCM04695.1 - 1.3 9.1 24.1 0.69 10.0 13.7 3.0 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Presenilin PF01080.17 CCM04695.1 - 6 5.5 6.8 9.2 4.9 6.8 1.2 1 0 0 1 1 1 0 Presenilin HMG_box_5 PF14887.6 CCM04695.1 - 8 6.5 8.8 0.21 11.6 0.9 2.2 2 0 0 2 2 2 0 HMG (high mobility group) box 5 COX6B PF02297.17 CCM04696.1 - 1.1e-17 64.0 7.5 1.4e-17 63.7 7.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb RRM_1 PF00076.22 CCM04697.1 - 1.8e-13 50.1 0.2 3e-13 49.4 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2464 PF10240.9 CCM04697.1 - 1.6 8.2 0.0 1.6 8.2 0.0 2.5 2 1 0 2 2 2 0 Multivesicular body subunit 12 P34-Arc PF04045.14 CCM04698.1 - 4.8e-108 360.4 0.0 5.9e-108 360.1 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Tweety PF04906.13 CCM04698.1 - 0.031 12.9 0.0 0.042 12.5 0.0 1.1 1 0 0 1 1 1 0 Tweety Homeodomain PF00046.29 CCM04699.1 - 1.2e-18 66.6 4.1 4.5e-18 64.9 4.2 1.9 2 0 0 2 2 2 1 Homeodomain ATG16 PF08614.11 CCM04699.1 - 0.15 12.3 5.0 0.28 11.4 5.0 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Homeobox_KN PF05920.11 CCM04699.1 - 0.22 11.4 0.7 0.61 10.0 0.7 1.7 1 0 0 1 1 1 0 Homeobox KN domain NAM-associated PF14303.6 CCM04699.1 - 0.24 12.1 2.4 0.73 10.5 2.4 1.8 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain U1snRNP70_N PF12220.8 CCM04700.1 - 1.6e-25 89.6 0.8 2.3e-25 89.0 0.8 1.3 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 CCM04700.1 - 5.3e-18 64.6 0.0 9.2e-18 63.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UbiA PF01040.18 CCM04701.1 - 3.3e-59 200.2 17.8 4.7e-59 199.7 17.8 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Mcp5_PH PF12814.7 CCM04701.1 - 0.019 15.1 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology zf-C2H2_jaz PF12171.8 CCM04702.1 - 0.025 14.9 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding OrsD PF12013.8 CCM04702.1 - 0.05 14.0 0.2 0.05 14.0 0.2 1.7 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_2 PF12756.7 CCM04702.1 - 0.14 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Citrate_synt PF00285.21 CCM04703.1 - 2.2e-98 329.6 0.0 2.7e-98 329.4 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 CCM04703.1 - 0.034 13.8 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Eclosion hormone Methyltransf_4 PF02390.17 CCM04704.1 - 4.1e-52 176.1 0.0 5.3e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 CCM04704.1 - 0.00017 22.2 0.0 0.00049 20.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM04704.1 - 0.021 15.5 0.0 0.09 13.4 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CCM04704.1 - 0.033 14.9 0.0 0.11 13.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 CCM04704.1 - 0.057 13.0 0.0 0.35 10.4 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain RNase_PH PF01138.21 CCM04705.1 - 4.2e-37 127.6 0.1 9.2e-37 126.5 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCM04705.1 - 0.00024 21.0 0.0 0.00052 20.0 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 NAPRTase PF04095.16 CCM04706.1 - 2.9e-59 200.6 0.0 4.7e-59 199.9 0.0 1.3 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 CCM04706.1 - 2.7e-38 131.2 0.1 4.3e-38 130.5 0.1 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain SH3_6 PF12913.7 CCM04706.1 - 0.087 12.4 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) Terpene_synth_C PF03936.16 CCM04708.1 - 1.8e-06 27.5 0.0 4.7e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain SPOB_ab PF14682.6 CCM04708.1 - 0.066 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal WD40 PF00400.32 CCM04709.1 - 1.7e-26 91.9 22.2 0.0002 22.1 0.0 7.9 7 1 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 CCM04709.1 - 1.3e-12 47.4 2.1 1.3e-12 47.4 2.1 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM04709.1 - 7.2e-11 41.7 5.0 3.1e-09 36.5 2.5 2.8 2 0 0 2 2 2 1 F-box domain WD40_like PF17005.5 CCM04709.1 - 0.00012 21.6 0.0 0.003 16.9 0.0 2.6 2 1 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 CCM04709.1 - 0.00012 20.9 4.1 0.98 8.0 0.0 4.1 3 1 1 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CCM04709.1 - 0.0011 19.2 0.5 0.73 10.2 0.0 3.8 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 CCM04709.1 - 0.0065 16.3 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 F-box DUF5046 PF16465.5 CCM04709.1 - 0.05 13.0 0.0 8.6 5.7 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5046) Aminotran_5 PF00266.19 CCM04710.1 - 4e-79 266.3 0.4 1.6e-65 221.5 0.1 2.1 1 1 1 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCM04710.1 - 8e-08 31.9 0.3 1.2e-07 31.3 0.3 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CCM04710.1 - 0.06 11.9 0.0 0.086 11.4 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Peripla_BP_4 PF13407.6 CCM04710.1 - 0.15 11.6 0.0 0.58 9.7 0.0 1.8 1 1 1 2 2 2 0 Periplasmic binding protein domain RRM_1 PF00076.22 CCM04711.1 - 3.5e-30 103.6 0.0 1.4e-16 60.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCM04711.1 - 3.4e-05 23.8 0.0 0.002 18.1 0.0 2.4 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CCM04711.1 - 0.0001 22.3 0.0 0.00073 19.5 0.0 2.0 2 0 0 2 2 2 1 RNA binding motif Limkain-b1 PF11608.8 CCM04711.1 - 0.0066 16.5 0.1 0.29 11.2 0.0 2.3 2 0 0 2 2 2 1 Limkain b1 HET PF06985.11 CCM04712.1 - 8.3e-09 35.9 5.7 1.1e-06 29.1 0.5 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) DUF3429 PF11911.8 CCM04713.1 - 2.1e-38 131.9 15.2 3e-38 131.3 15.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) T6SS_HCP PF05638.12 CCM04713.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Type VI secretion system effector, Hcp CAP_GLY PF01302.25 CCM04714.1 - 3.7e-19 68.5 0.6 7.4e-19 67.5 0.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_8 PF13855.6 CCM04714.1 - 1.9e-14 53.2 4.7 3.3e-06 26.8 0.5 4.9 4 2 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 CCM04714.1 - 3e-13 49.7 5.7 2.8e-05 24.4 0.2 6.2 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CCM04714.1 - 5.7e-08 32.5 0.0 5.7e-06 25.9 0.0 2.4 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.33 CCM04714.1 - 0.00016 21.7 1.9 37 5.4 0.1 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.6 CCM04714.1 - 0.4 10.8 13.0 1.6 9.0 0.4 6.0 7 0 0 7 7 7 0 Leucine Rich repeat ECH_2 PF16113.5 CCM04715.1 - 1.6e-111 373.0 0.0 2.5e-111 372.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CCM04715.1 - 6e-25 88.0 0.0 7.7e-23 81.1 0.0 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF2497 PF10691.9 CCM04715.1 - 0.13 12.7 0.3 11 6.5 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2497) Skp1 PF01466.19 CCM04716.1 - 4e-29 100.5 0.4 7e-29 99.7 0.4 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 CCM04716.1 - 4.4e-25 87.6 1.6 5.9e-25 87.2 0.2 2.0 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain BTB PF00651.31 CCM04716.1 - 0.0018 18.5 0.0 0.075 13.3 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain Ribosomal_L27 PF01016.19 CCM04717.1 - 2.9e-34 116.9 0.4 3.9e-34 116.5 0.4 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein F-box-like PF12937.7 CCM04718.1 - 1.2e-10 41.1 1.9 4.7e-10 39.2 1.9 2.1 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 CCM04718.1 - 0.14 12.8 0.5 6.8 7.7 0.0 4.0 6 0 0 6 6 6 0 Leucine Rich Repeat DUF3074 PF11274.8 CCM04719.1 - 2.6e-40 138.4 0.0 3.6e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Gln-synt_C PF00120.24 CCM04720.1 - 4.5e-72 242.9 0.0 1.3e-71 241.4 0.0 1.6 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Skp1 PF01466.19 CCM04720.1 - 7.3e-10 38.8 0.0 1.7e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 CCM04720.1 - 0.035 14.3 0.0 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Reg_prop PF07494.11 CCM04721.1 - 0.067 13.4 0.2 30 5.3 0.0 3.6 3 0 0 3 3 3 0 Two component regulator propeller Utp21 PF04192.12 CCM04722.1 - 4.7e-58 196.4 0.9 8.6e-58 195.6 0.9 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 CCM04722.1 - 2.2e-14 53.6 11.0 0.0011 19.8 0.0 8.0 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04722.1 - 3.8e-13 49.6 0.0 0.00011 22.4 0.0 6.3 3 2 5 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain SRPRB PF09439.10 CCM04723.1 - 8.7e-23 80.7 0.0 1.2e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 CCM04723.1 - 4e-17 62.2 0.0 5.8e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM04723.1 - 1.1e-08 34.7 0.0 1.5e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM04723.1 - 1.2e-08 35.0 0.0 1.8e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 CCM04723.1 - 1e-05 25.7 0.0 1.7e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CCM04723.1 - 2.7e-05 23.8 0.3 0.011 15.3 0.0 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 CCM04723.1 - 3.7e-05 23.3 0.1 0.0045 16.5 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region G-alpha PF00503.20 CCM04723.1 - 0.00075 18.8 0.1 0.5 9.5 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CCM04723.1 - 0.001 18.7 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Ras family TniB PF05621.11 CCM04723.1 - 0.0012 18.3 0.0 0.0043 16.5 0.0 1.8 2 0 0 2 2 2 1 Bacterial TniB protein AAA_16 PF13191.6 CCM04723.1 - 0.012 16.0 0.9 0.058 13.8 0.9 2.1 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 CCM04723.1 - 0.027 14.0 0.1 0.064 12.8 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 CCM04723.1 - 0.064 13.0 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CCM04723.1 - 0.09 13.1 0.0 0.21 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain Mannosyl_trans PF05007.13 CCM04724.1 - 1.2e-75 254.7 20.0 1.6e-75 254.3 20.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) Arf PF00025.21 CCM04724.1 - 9.2e-63 210.8 0.0 1.4e-62 210.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PIG-U PF06728.13 CCM04724.1 - 3.3e-10 39.6 5.5 3.3e-10 39.6 5.5 1.8 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U SRPRB PF09439.10 CCM04724.1 - 9.4e-10 38.2 0.0 1.4e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CCM04724.1 - 2.5e-09 36.8 0.0 1.9e-06 27.3 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 CCM04724.1 - 1.4e-06 28.3 0.0 2.6e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 CCM04724.1 - 4.4e-06 26.9 0.0 9.1e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCM04724.1 - 9.3e-05 22.1 0.0 0.00015 21.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CCM04724.1 - 0.0025 17.2 0.0 0.0035 16.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Cofilin_ADF PF00241.20 CCM04725.1 - 7e-17 61.4 0.0 7.9e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein MFS_1 PF07690.16 CCM04726.1 - 5.5e-21 74.9 31.4 3.1e-16 59.3 20.5 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM04726.1 - 3.2e-05 23.0 6.7 3.2e-05 23.0 6.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM04727.1 - 1.4e-23 83.4 31.3 1.1e-15 57.5 23.1 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF997 PF06196.12 CCM04727.1 - 0.027 14.5 2.7 0.1 12.6 2.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF997) Exo_endo_phos PF03372.23 CCM04728.1 - 1.8e-08 34.2 0.0 9e-08 31.9 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3040 PF11239.8 CCM04728.1 - 6.4 7.1 5.9 6.6 7.1 0.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) Ribosomal_L3 PF00297.22 CCM04729.1 - 1.1e-23 83.9 3.0 3.4e-21 75.6 0.9 2.2 1 1 1 2 2 2 2 Ribosomal protein L3 Rrn6 PF10214.9 CCM04730.1 - 2.1e-11 43.1 4.2 9.4e-06 24.4 0.7 3.3 3 0 0 3 3 3 3 RNA polymerase I-specific transcription-initiation factor Mito_carr PF00153.27 CCM04731.1 - 7e-40 134.9 0.7 6.1e-15 54.9 0.1 3.9 4 1 0 4 4 4 3 Mitochondrial carrier protein MOR2-PAG1_N PF14222.6 CCM04734.1 - 2.1e-167 558.4 0.0 8.5e-166 553.1 0.0 2.3 2 0 0 2 2 2 2 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 CCM04734.1 - 6.6e-89 298.1 5.3 1.2e-88 297.2 1.6 3.2 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 CCM04734.1 - 5.1e-21 74.1 0.2 1.4e-11 42.9 0.0 3.1 3 0 0 3 3 3 3 Cell morphogenesis central region PBP1_TM PF14812.6 CCM04735.1 - 0.21 11.9 2.9 0.67 10.4 2.9 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 CCM04735.1 - 2.3 8.7 6.5 4.9 7.6 6.5 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Mlh1_C PF16413.5 CCM04736.1 - 1e-93 313.6 1.7 1.3e-93 313.3 0.0 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 CCM04736.1 - 8.1e-29 99.7 0.0 1.4e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CCM04736.1 - 1.5e-11 44.2 0.0 3.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CCM04736.1 - 1.9e-08 34.8 0.0 4.6e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RPN1_RPN2_N PF17781.1 CCM04738.1 - 1.2e-105 353.3 0.0 1.9e-105 352.7 0.0 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CCM04738.1 - 2.2e-29 101.2 0.1 4.6e-29 100.2 0.1 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CCM04738.1 - 5.4e-23 80.2 15.2 6.2e-05 23.2 0.1 8.1 7 0 0 7 7 7 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CCM04738.1 - 0.00027 21.3 1.1 3.2 8.2 0.0 4.3 5 1 1 6 6 6 3 HEAT repeats STE3 PF02076.15 CCM04739.1 - 0.18 11.0 3.8 0.3 10.3 3.8 1.3 1 0 0 1 1 1 0 Pheromone A receptor DSPc PF00782.20 CCM04740.1 - 0.00019 21.3 0.0 0.00036 20.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CCM04740.1 - 0.047 13.6 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 CCM04740.1 - 0.22 11.1 0.0 0.36 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Acetyltransf_9 PF13527.7 CCM04741.1 - 0.0085 16.2 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM04741.1 - 0.18 12.2 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF917 PF06032.12 CCM04742.1 - 1.7e-119 398.7 0.0 2.7e-119 398.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 CCM04742.1 - 1.4e-08 34.4 3.1 0.0018 17.6 0.5 2.4 1 1 1 2 2 2 2 Hydantoinase/oxoprolinase LCIB_C_CA PF18599.1 CCM04742.1 - 0.15 11.3 0.3 0.69 9.2 0.2 1.8 1 1 1 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Amidase PF01425.21 CCM04743.1 - 2e-80 270.9 0.0 2.6e-80 270.6 0.0 1.1 1 0 0 1 1 1 1 Amidase FAM193_C PF15914.5 CCM04744.1 - 0.087 12.6 0.0 0.087 12.6 0.0 3.3 3 0 0 3 3 3 0 FAM193 family C-terminal Fic PF02661.18 CCM04745.1 - 4.8e-07 30.6 0.0 1.2e-06 29.3 0.0 1.7 1 1 0 1 1 1 1 Fic/DOC family adh_short PF00106.25 CCM04748.1 - 2.2e-40 138.2 0.5 2.9e-40 137.8 0.5 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04748.1 - 4.6e-37 127.8 0.8 6.2e-37 127.4 0.8 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04748.1 - 1.9e-13 50.8 1.7 4.1e-13 49.6 0.9 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CCM04748.1 - 2.1e-06 27.4 0.1 3.3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCM04748.1 - 9.7e-05 21.6 0.1 0.00015 21.0 0.1 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 CCM04748.1 - 0.056 13.2 0.2 0.16 11.8 0.2 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_4 PF07993.12 CCM04748.1 - 0.083 12.0 0.0 0.25 10.5 0.0 1.7 1 1 0 1 1 1 0 Male sterility protein DASH_Dam1 PF08653.10 CCM04749.1 - 2.6e-24 84.8 0.1 4.6e-24 84.0 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Dam1 DUF4519 PF15012.6 CCM04749.1 - 0.2 11.9 2.8 0.31 11.2 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) TFIIF_alpha PF05793.12 CCM04750.1 - 0.0025 16.5 20.8 0.0036 16.0 20.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 CCM04750.1 - 0.003 17.0 20.3 0.0053 16.2 20.3 1.3 1 0 0 1 1 1 1 SDA1 CNDH2_C PF16858.5 CCM04750.1 - 0.0056 16.6 0.4 0.011 15.7 0.4 1.5 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 CCM04750.1 - 0.018 13.4 11.1 0.024 13.0 11.1 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 CCM04750.1 - 0.022 14.9 15.7 0.04 14.0 15.7 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 CCM04750.1 - 0.031 12.5 19.9 0.048 11.9 19.9 1.3 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 CCM04750.1 - 0.52 9.6 27.4 0.95 8.7 27.4 1.4 1 0 0 1 1 1 0 BUD22 Astro_capsid_p PF12226.8 CCM04750.1 - 0.85 8.7 15.5 1.7 7.7 15.5 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SpoIIIAH PF12685.7 CCM04750.1 - 0.89 9.3 9.9 1.5 8.6 9.9 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Mpp10 PF04006.12 CCM04750.1 - 1.6 7.1 18.8 2.3 6.5 18.8 1.2 1 0 0 1 1 1 0 Mpp10 protein Paf1 PF03985.13 CCM04750.1 - 2.1 7.3 16.1 3.2 6.7 16.1 1.2 1 0 0 1 1 1 0 Paf1 LAP1C PF05609.12 CCM04750.1 - 3.3 6.7 11.4 5.4 6.0 11.4 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Presenilin PF01080.17 CCM04750.1 - 3.7 6.2 4.3 5.3 5.7 4.3 1.4 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 CCM04750.1 - 7.4 6.0 11.1 12 5.3 11.1 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Cnd1_N PF12922.7 CCM04752.1 - 1.3e-58 197.5 1.3 5.8e-58 195.4 0.0 3.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 CCM04752.1 - 1e-51 175.2 7.3 1.1e-48 165.3 0.3 4.2 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCM04752.1 - 3.3e-08 33.8 0.8 0.091 13.2 0.1 5.2 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 CCM04752.1 - 2.1e-05 24.4 3.7 5.4 7.5 0.0 6.2 6 0 0 6 6 6 2 HEAT repeat RTP1_C1 PF10363.9 CCM04752.1 - 0.0096 16.1 3.9 10 6.3 0.1 4.2 2 1 2 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 CCM04752.1 - 0.014 14.0 9.8 0.13 10.8 0.5 3.6 3 2 0 3 3 3 0 Adaptin N terminal region YtzH PF14165.6 CCM04752.1 - 0.016 15.6 1.0 0.11 12.9 0.1 3.0 2 1 1 3 3 3 0 YtzH-like protein QueF PF14489.6 CCM04752.1 - 0.15 12.2 0.1 14 5.9 0.0 2.7 2 0 0 2 2 2 0 QueF-like protein HEAT_EZ PF13513.6 CCM04752.1 - 0.65 10.6 2.8 96 3.6 0.0 4.4 4 0 0 4 4 4 0 HEAT-like repeat PIP5K PF01504.18 CCM04753.1 - 3.1e-102 341.5 0.0 6.3e-102 340.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF1295 PF06966.12 CCM04754.1 - 2e-10 40.6 0.1 2.1e-10 40.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCM04754.1 - 0.068 13.6 0.1 0.068 13.6 0.1 1.1 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Asp PF00026.23 CCM04756.1 - 2.5e-45 155.3 6.6 1.1e-44 153.2 6.6 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM04756.1 - 0.0011 19.3 0.3 0.017 15.4 0.1 2.4 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal DUF4012 PF13196.6 CCM04756.1 - 0.041 14.4 0.1 0.12 12.8 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4012) DUF4027 PF13219.6 CCM04756.1 - 0.16 11.9 0.8 3 7.8 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4027) TAXi_C PF14541.6 CCM04756.1 - 1.5 8.6 3.8 0.8 9.5 0.1 2.3 3 0 0 3 3 3 0 Xylanase inhibitor C-terminal Asp PF00026.23 CCM04757.1 - 9.1e-45 153.4 7.2 3e-44 151.7 7.2 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM04757.1 - 7.5e-06 26.3 2.8 0.0017 18.6 0.1 2.7 1 1 2 3 3 3 2 Xylanase inhibitor N-terminal DDE_1 PF03184.19 CCM04757.1 - 0.074 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease TAXi_C PF14541.6 CCM04757.1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal NMD3 PF04981.13 CCM04758.1 - 6e-80 268.2 0.4 7.8e-80 267.8 0.4 1.1 1 0 0 1 1 1 1 NMD3 family DZR PF12773.7 CCM04758.1 - 0.029 14.4 6.5 0.094 12.8 3.1 2.6 1 1 2 3 3 3 0 Double zinc ribbon NinF PF05810.12 CCM04758.1 - 0.036 14.0 0.7 0.17 11.8 0.7 2.1 1 0 0 1 1 1 0 NinF protein Rpr2 PF04032.16 CCM04758.1 - 0.07 13.4 2.4 9.9 6.5 0.1 2.8 2 1 1 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain adh_short PF00106.25 CCM04759.1 - 3.6e-29 101.6 0.0 4.8e-29 101.2 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04759.1 - 2.4e-18 66.5 0.0 2.9e-18 66.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04759.1 - 2.8e-08 33.9 0.0 3.6e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM04759.1 - 0.026 14.4 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding NAD_binding_4 PF07993.12 CCM04759.1 - 0.03 13.5 0.0 0.22 10.7 0.0 2.1 1 1 0 1 1 1 0 Male sterility protein Epimerase PF01370.21 CCM04759.1 - 0.043 13.3 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 CCM04760.1 - 1.2e-24 86.8 0.0 1.7e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04760.1 - 4.9e-16 59.0 0.0 6e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04760.1 - 5e-06 26.5 0.0 5.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM04760.1 - 6e-05 23.0 0.0 0.00015 21.7 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CCM04760.1 - 0.13 11.4 0.1 2.7 7.1 0.0 2.3 2 1 0 2 2 2 0 Male sterility protein PDZ_5 PF17817.1 CCM04761.1 - 0.16 12.3 1.3 0.93 9.8 0.2 2.5 2 0 0 2 2 2 0 PDZ domain PEP_mutase PF13714.6 CCM04762.1 - 1.9e-45 155.2 1.9 2.3e-45 154.9 1.9 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CCM04762.1 - 2e-19 69.5 0.2 2.8e-19 69.0 0.2 1.1 1 0 0 1 1 1 1 Isocitrate lyase family PEP_hydrolase PF09370.10 CCM04762.1 - 0.041 13.1 0.0 0.11 11.7 0.0 1.7 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like GLE1 PF07817.13 CCM04763.1 - 2.7e-43 148.0 0.0 4.7e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 GLE1-like protein WD40 PF00400.32 CCM04764.1 - 4.7e-36 122.2 22.8 8e-08 32.8 0.4 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.7 CCM04764.1 - 2.1e-13 49.9 0.7 2.1e-13 49.9 0.7 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM04764.1 - 5.5e-08 32.5 0.4 1.6e-07 31.1 0.4 1.8 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 CCM04764.1 - 2.3e-07 31.0 0.1 1.4 9.3 0.0 5.8 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCM04764.1 - 4.8e-06 25.5 1.3 0.33 9.5 0.0 4.7 3 1 2 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 CCM04764.1 - 0.016 14.6 0.0 0.88 8.8 0.0 2.7 2 1 1 3 3 3 0 WD40-like domain SWIM PF04434.17 CCM04764.1 - 0.024 14.3 0.1 0.053 13.2 0.1 1.6 1 0 0 1 1 1 0 SWIM zinc finger PQQ_3 PF13570.6 CCM04764.1 - 0.41 11.2 4.9 1.1 9.9 0.0 4.0 4 1 1 5 5 5 0 PQQ-like domain Thymidylat_synt PF00303.19 CCM04765.1 - 5.9e-104 346.9 0.0 6.7e-104 346.8 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Cnd3 PF12719.7 CCM04766.1 - 4.7e-85 285.3 0.9 1.2e-84 284.0 0.1 2.0 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 CCM04766.1 - 0.00012 22.4 0.4 0.011 16.1 0.1 3.7 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 CCM04766.1 - 0.00022 21.2 3.4 10 6.7 0.0 5.6 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 CCM04766.1 - 0.04 14.4 0.9 54 4.4 0.0 4.2 3 1 0 3 3 3 0 HEAT-like repeat ABC_tran_Xtn PF12848.7 CCM04766.1 - 0.23 11.5 1.7 1.1 9.3 0.1 2.7 2 0 0 2 2 2 0 ABC transporter Cnd1 PF12717.7 CCM04766.1 - 0.43 10.6 4.7 5.1 7.1 0.2 3.9 3 1 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 DUF3827 PF12877.7 CCM04766.1 - 4.1 5.7 9.0 6.3 5.1 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) BLOC1S3 PF15753.5 CCM04766.1 - 4.6 7.3 6.2 5.2 7.2 4.0 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 adh_short PF00106.25 CCM04769.1 - 2e-19 69.8 0.0 3.1e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04769.1 - 1.4e-08 34.6 0.0 3.6e-08 33.3 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04769.1 - 1.4e-05 25.0 0.0 2.2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CCM04769.1 - 0.065 12.6 0.0 0.082 12.3 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short_C2 PF13561.6 CCM04770.1 - 3.4e-09 36.6 0.0 0.00022 20.9 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM04770.1 - 0.00029 20.3 0.0 0.00051 19.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase TFIIE_alpha PF02002.17 CCM04771.1 - 8.4e-18 64.2 0.4 1.5e-17 63.4 0.4 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 CCM04771.1 - 0.00063 19.2 0.6 0.0013 18.2 0.6 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding TFIIE-A_C PF11521.8 CCM04771.1 - 0.00073 19.8 0.6 0.0036 17.6 0.6 2.2 1 1 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha zf_UBZ PF18439.1 CCM04771.1 - 0.0048 16.5 0.7 0.31 10.7 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 CCM04771.1 - 0.0072 16.3 0.4 0.19 11.7 0.1 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 CCM04771.1 - 0.053 14.4 0.8 1.2 10.2 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger DZR PF12773.7 CCM04771.1 - 0.13 12.3 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-C4_ClpX PF06689.13 CCM04771.1 - 0.38 10.7 2.8 4.4 7.3 2.1 2.4 1 1 1 2 2 2 0 ClpX C4-type zinc finger zf-C2H2 PF00096.26 CCM04771.1 - 0.8 10.3 2.0 1.1 9.8 0.2 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type LRR_6 PF13516.6 CCM04772.1 - 9.5e-07 28.4 17.7 0.13 12.4 0.1 6.9 7 0 0 7 7 7 3 Leucine Rich repeat F-box PF00646.33 CCM04772.1 - 0.069 13.0 0.7 0.17 11.8 0.2 2.0 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 CCM04772.1 - 0.083 12.8 0.7 0.17 11.8 0.7 1.6 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 CCM04772.1 - 0.35 11.4 12.3 3.1 8.4 1.4 4.3 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) GPI-anchored PF10342.9 CCM04773.1 - 5.8e-07 30.2 0.1 7.8e-07 29.8 0.1 1.1 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Mem_trans PF03547.18 CCM04774.1 - 8.5e-37 126.5 4.6 1.1e-31 109.6 0.2 2.9 2 1 0 2 2 2 2 Membrane transport protein Lant_dehydr_C PF14028.6 CCM04774.1 - 0.074 12.6 0.8 5.7 6.4 0.1 2.4 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term GPI-anchored PF10342.9 CCM04775.1 - 3.6e-07 30.8 0.1 4.7e-07 30.5 0.1 1.1 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family GPI-anchored PF10342.9 CCM04776.1 - 3.5e-07 30.9 1.5 4.3e-07 30.6 1.5 1.1 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Uso1_p115_head PF04869.14 CCM04778.1 - 5.5e-47 160.4 0.0 4.2e-46 157.5 0.0 2.2 1 1 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 CCM04778.1 - 6.5e-15 55.6 21.6 1.1e-14 54.9 21.6 1.3 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region Rcd1 PF04078.13 CCM04778.1 - 0.0014 18.0 0.4 0.0043 16.4 0.1 1.8 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like TMF_TATA_bd PF12325.8 CCM04778.1 - 0.0085 16.3 9.4 0.017 15.3 9.4 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.22 CCM04778.1 - 0.01 16.0 2.3 0.064 13.5 3.2 1.9 2 0 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain COMP PF11598.8 CCM04778.1 - 0.022 15.2 1.3 0.044 14.3 0.0 2.2 2 0 0 2 2 1 0 Cartilage oligomeric matrix protein Golgin_A5 PF09787.9 CCM04778.1 - 0.039 13.4 8.5 0.065 12.7 8.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 APG6_N PF17675.1 CCM04778.1 - 0.083 13.4 13.9 0.16 12.5 13.9 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Herpes_TAF50 PF03326.13 CCM04778.1 - 0.088 11.4 0.6 0.16 10.6 0.6 1.3 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) FlxA PF14282.6 CCM04778.1 - 0.15 12.0 6.4 0.27 11.2 6.4 1.4 1 0 0 1 1 1 0 FlxA-like protein DUF2570 PF10828.8 CCM04778.1 - 0.19 11.5 2.8 0.57 10.0 2.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Atx10homo_assoc PF09759.9 CCM04778.1 - 0.21 11.6 2.1 8.5 6.5 0.0 3.3 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Phage_GPO PF05929.11 CCM04778.1 - 0.33 10.5 4.1 0.56 9.8 4.1 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Cep57_MT_bd PF06657.13 CCM04778.1 - 0.34 11.4 8.0 0.13 12.8 1.2 2.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 OmpH PF03938.14 CCM04778.1 - 0.46 10.8 7.9 1.2 9.4 7.9 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TolA_bind_tri PF16331.5 CCM04778.1 - 0.73 9.9 10.2 4.1 7.6 10.2 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation RasGAP_C PF03836.15 CCM04778.1 - 0.78 9.9 5.1 1.6 8.8 5.1 1.5 1 0 0 1 1 1 0 RasGAP C-terminus Spc7 PF08317.11 CCM04778.1 - 1.3 7.9 10.4 2 7.2 10.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 CCM04778.1 - 1.4 9.6 8.1 97 3.7 8.1 2.8 1 1 0 1 1 1 0 SlyX MIF4G_like_2 PF09090.11 CCM04778.1 - 1.5 8.3 4.8 2.7 7.4 4.8 1.3 1 0 0 1 1 1 0 MIF4G like DUF2968 PF11180.8 CCM04778.1 - 1.7 8.2 10.5 4 7.0 10.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) F-box-like PF12937.7 CCM04779.1 - 0.037 13.9 0.1 0.13 12.2 0.1 2.0 1 0 0 1 1 1 0 F-box-like HA1 PF18239.1 CCM04779.1 - 0.093 12.6 0.0 10 6.0 0.0 2.7 3 0 0 3 3 3 0 Hemagglutinin I Sacchrp_dh_NADP PF03435.18 CCM04780.1 - 2.3e-09 37.6 0.0 4.2e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 CCM04780.1 - 3.5e-08 33.6 0.2 5.1e-08 33.0 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCM04780.1 - 5e-05 22.9 0.1 8.3e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCM04780.1 - 0.00025 21.5 0.0 0.00082 19.8 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 CCM04780.1 - 0.00031 20.7 0.1 0.00063 19.7 0.1 1.5 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CCM04780.1 - 0.00045 19.9 0.0 0.00065 19.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CCM04780.1 - 0.0058 16.1 0.0 0.0096 15.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.19 CCM04780.1 - 0.021 13.9 0.0 0.029 13.4 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CCM04780.1 - 0.075 12.4 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 CCM04780.1 - 0.084 13.5 0.0 0.25 12.0 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_M20 PF01546.28 CCM04782.1 - 5.5e-32 111.2 0.0 1.6e-31 109.7 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM04782.1 - 7.2e-09 35.5 0.2 1.6e-08 34.4 0.2 1.6 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CCM04782.1 - 0.044 13.5 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 DDE_Tnp_4 PF13359.6 CCM04783.1 - 3.1e-28 98.4 0.0 3.7e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CCM04783.1 - 3.7e-11 43.1 0.0 8.7e-11 41.9 0.0 1.6 1 1 0 1 1 1 1 Transposase DDE domain tRNA-synt_2d PF01409.20 CCM04785.1 - 1.8e-83 279.8 0.0 4.9e-55 186.7 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 CCM04785.1 - 2.1e-16 59.9 0.3 7.8e-16 58.1 0.4 2.0 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 CCM04785.1 - 1.4e-08 34.5 0.0 7e-05 22.4 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 CCM04785.1 - 0.00038 20.4 0.4 0.0011 18.9 0.2 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 2 tRNA-synt_2 PF00152.20 CCM04785.1 - 0.001 18.2 0.1 0.028 13.5 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 CCM04785.1 - 0.016 15.2 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Pex2_Pex12 PF04757.14 CCM04786.1 - 5.6e-33 114.4 9.5 7.1e-33 114.1 9.5 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_5 PF14634.6 CCM04786.1 - 0.00019 21.3 2.8 0.00026 20.9 0.6 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCM04786.1 - 0.0022 17.8 3.1 0.019 14.8 3.1 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM04786.1 - 0.0033 17.4 0.6 0.011 15.8 0.1 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CCM04786.1 - 0.0072 16.1 2.2 0.015 15.2 0.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCM04786.1 - 0.011 15.9 0.9 0.027 14.6 0.2 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CCM04786.1 - 0.35 11.2 3.8 0.87 10.0 0.7 2.3 2 0 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 CCM04786.1 - 0.54 10.2 2.1 0.64 9.9 0.2 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCM04786.1 - 0.63 9.9 5.9 1.4 8.9 2.5 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cullin PF00888.22 CCM04787.1 - 7.2e-62 209.9 0.5 1.1e-60 206.0 0.5 2.2 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCM04787.1 - 5.2e-24 84.0 5.5 2.6e-23 81.8 5.2 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain Cullin PF00888.22 CCM04788.1 - 3.6e-05 22.6 0.0 4e-05 22.4 0.0 1.0 1 0 0 1 1 1 1 Cullin family CDC27 PF09507.10 CCM04789.1 - 3e-42 145.5 46.6 1.7e-40 139.7 46.6 2.2 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 IBN_N PF03810.19 CCM04790.1 - 1e-10 41.4 0.1 6.4e-07 29.2 0.2 3.2 2 0 0 2 2 2 2 Importin-beta N-terminal domain Xpo1 PF08389.12 CCM04790.1 - 0.036 14.1 0.0 0.83 9.7 0.0 3.3 2 0 0 2 2 2 0 Exportin 1-like protein Slx4 PF09494.10 CCM04791.1 - 1.6e-05 24.8 0.9 2.8e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Slx4 endonuclease Med3 PF11593.8 CCM04791.1 - 1.4 8.0 7.4 0.04 13.1 0.6 1.8 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Mur_ligase_M PF08245.12 CCM04792.1 - 0.00077 19.5 0.1 0.35 10.8 0.0 3.0 2 1 1 3 3 3 2 Mur ligase middle domain Fe-ADH PF00465.19 CCM04793.1 - 2.2e-89 299.9 0.0 2.8e-89 299.5 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCM04793.1 - 2.6e-09 37.1 0.0 6.5e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Asp PF00026.23 CCM04794.1 - 2.8e-35 122.2 0.3 8e-34 117.5 0.3 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM04794.1 - 1.2e-05 25.6 2.2 0.0022 18.3 0.1 3.2 2 1 1 3 3 3 1 Xylanase inhibitor N-terminal DUF1180 PF06679.12 CCM04794.1 - 0.053 13.9 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PPR_2 PF13041.6 CCM04795.1 - 6.7e-14 51.8 0.1 1e-07 32.0 0.0 4.6 6 0 0 6 6 6 2 PPR repeat family PPR PF01535.20 CCM04795.1 - 0.00014 21.9 5.3 3.7 8.0 0.0 6.0 7 0 0 7 7 7 1 PPR repeat PPR_3 PF13812.6 CCM04795.1 - 0.00067 19.7 0.0 43 4.3 0.0 4.9 4 1 1 5 5 5 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCM04795.1 - 0.029 14.0 2.0 11 5.8 0.0 4.1 5 0 0 5 5 5 0 PPR repeat DAO PF01266.24 CCM04796.1 - 1.8e-35 123.2 0.0 2.3e-35 122.9 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase TPR_1 PF00515.28 CCM04797.1 - 1.8e-14 52.8 6.2 9.2e-07 28.4 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCM04797.1 - 4.4e-10 38.9 3.6 7.7e-05 22.5 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CCM04797.1 - 7.6e-05 23.2 0.0 0.044 14.6 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM04797.1 - 0.00014 22.1 1.8 0.16 12.3 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM04797.1 - 0.00082 19.8 0.3 0.12 12.9 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCM04797.1 - 0.0019 18.3 0.9 0.032 14.4 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCM04797.1 - 0.008 16.1 0.1 4 7.7 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM04797.1 - 0.028 14.6 1.8 0.061 13.6 1.7 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CCM04797.1 - 0.06 13.0 0.0 11 5.8 0.0 2.6 2 0 0 2 2 2 0 TPR repeat Fis1_TPR_C PF14853.6 CCM04797.1 - 0.083 13.0 0.1 0.27 11.3 0.1 1.9 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat Spindle_Spc25 PF08234.12 CCM04798.1 - 1.8e-20 72.9 0.4 4.5e-20 71.6 0.4 1.7 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 DUF5381 PF17353.2 CCM04798.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5381) RICH PF05062.12 CCM04798.1 - 0.15 12.4 2.2 0.35 11.2 2.2 1.7 1 1 0 1 1 1 0 RICH domain DUF4200 PF13863.6 CCM04798.1 - 0.15 12.4 8.8 0.2 12.0 7.7 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Ribosomal_S7e PF01251.18 CCM04799.1 - 3.1e-88 294.4 2.5 3.5e-88 294.2 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e TBD PF12845.7 CCM04799.1 - 0.13 12.1 0.4 2.4 8.1 0.2 2.6 2 0 0 2 2 2 0 TBD domain Ras PF00071.22 CCM04800.1 - 6.6e-47 159.1 0.0 1.1e-43 148.6 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCM04800.1 - 1e-32 112.9 0.0 1.5e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM04800.1 - 4.2e-11 42.6 0.0 9.8e-11 41.4 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCM04800.1 - 3.1e-07 30.5 0.0 6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CCM04800.1 - 0.00087 18.8 0.4 0.0024 17.4 0.0 1.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCM04800.1 - 0.0016 17.8 0.0 0.0026 17.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 CCM04800.1 - 0.0025 17.6 0.1 0.086 12.6 0.1 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 CCM04800.1 - 0.0083 16.4 0.1 0.018 15.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CCM04800.1 - 0.013 15.4 0.1 0.047 13.6 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase Tir_receptor_C PF07489.11 CCM04800.1 - 0.018 15.0 0.1 0.033 14.2 0.1 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus AAA_16 PF13191.6 CCM04800.1 - 0.024 15.0 0.0 0.081 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 CCM04800.1 - 0.036 13.8 0.2 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CCM04800.1 - 0.09 12.3 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 CCM04800.1 - 0.12 11.7 0.1 0.45 9.9 0.1 1.8 2 0 0 2 2 2 0 Bacterial TniB protein Septin PF00735.18 CCM04800.1 - 0.17 11.1 0.1 0.48 9.7 0.1 1.7 2 0 0 2 2 2 0 Septin AAA_14 PF13173.6 CCM04800.1 - 0.17 11.9 0.1 0.7 9.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain AMMECR1 PF01871.17 CCM04801.1 - 1.5e-42 145.0 0.0 2.5e-42 144.3 0.0 1.3 1 1 0 1 1 1 1 AMMECR1 Ribosomal_L3 PF00297.22 CCM04802.1 - 7.9e-188 624.0 10.4 1e-187 623.6 10.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 PPR_2 PF13041.6 CCM04802.1 - 3.3e-08 33.6 0.2 0.098 12.9 0.0 4.3 4 0 0 4 4 4 3 PPR repeat family PPR PF01535.20 CCM04802.1 - 2.4e-07 30.6 1.0 0.013 15.7 0.0 5.7 6 0 0 6 6 6 1 PPR repeat PPR_3 PF13812.6 CCM04802.1 - 6.2e-06 26.2 0.0 0.017 15.2 0.0 2.6 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 CCM04802.1 - 7.8e-06 25.5 0.3 0.047 13.4 0.0 3.3 3 0 0 3 3 3 2 PPR repeat TPR_16 PF13432.6 CCM04802.1 - 0.56 10.9 1.9 1.2e+02 3.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat MRC1 PF09444.10 CCM04803.1 - 3.2e-29 102.3 24.6 3.2e-29 102.3 24.6 5.2 5 1 0 5 5 5 1 MRC1-like domain THOC2_N PF16134.5 CCM04804.1 - 2.3e-142 475.9 0.0 5e-142 474.7 0.0 1.6 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 CCM04804.1 - 6.8e-85 284.9 0.0 6.8e-85 284.9 0.0 2.0 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 CCM04804.1 - 1.7e-29 101.6 0.1 3.9e-29 100.5 0.1 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit GTP_cyclohydroI PF01227.22 CCM04805.1 - 2.3e-74 248.7 0.2 2.8e-74 248.4 0.2 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CCM04805.1 - 0.00079 19.5 0.0 0.0024 18.0 0.0 1.8 2 0 0 2 2 2 1 QueF-like protein HATPase_c_2 PF13581.6 CCM04805.1 - 0.046 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain ABC_tran PF00005.27 CCM04806.1 - 7.6e-16 58.9 0.0 2.2e-15 57.4 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCM04806.1 - 2.4e-05 24.3 0.3 0.00013 21.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM04806.1 - 0.019 14.4 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CCM04806.1 - 0.022 15.0 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.6 CCM04806.1 - 0.17 10.5 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain Pex2_Pex12 PF04757.14 CCM04807.1 - 1.9e-39 135.6 4.8 3.1e-39 134.9 4.8 1.4 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region Ank_2 PF12796.7 CCM04807.1 - 2.8e-38 130.4 0.0 5.6e-13 49.3 0.1 4.6 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CCM04807.1 - 2.1e-26 91.9 3.7 8.1e-08 32.7 0.1 5.2 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM04807.1 - 1.2e-21 74.5 6.1 0.00078 19.7 0.0 8.5 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 CCM04807.1 - 2e-20 72.6 8.3 1.7e-05 25.0 0.0 5.6 2 1 4 6 6 6 6 Ankyrin repeats (many copies) SPX PF03105.19 CCM04807.1 - 7.5e-20 72.2 9.2 1.5e-08 34.9 0.2 3.2 1 1 2 3 3 3 3 SPX domain Ank PF00023.30 CCM04807.1 - 6.2e-18 64.4 7.2 0.12 12.8 0.0 7.8 6 1 0 6 6 6 4 Ankyrin repeat GDPD PF03009.17 CCM04807.1 - 1e-11 45.1 0.0 3.1e-11 43.5 0.0 1.7 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family MDM10 PF12519.8 CCM04810.1 - 6.8e-82 275.8 1.0 1.4e-54 185.7 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial distribution and morphology protein 10 Brix PF04427.18 CCM04812.1 - 6.6e-26 91.6 0.2 1e-25 91.0 0.2 1.3 1 0 0 1 1 1 1 Brix domain LSM PF01423.22 CCM04812.1 - 5.6e-14 51.6 0.0 1e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 LSM domain Peptidase_M18 PF02127.15 CCM04813.1 - 7.2e-154 512.7 0.0 8.2e-154 512.5 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CCM04813.1 - 8e-08 31.6 0.1 3.3e-06 26.3 0.1 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase WD40 PF00400.32 CCM04814.1 - 5.8e-52 172.5 24.5 2.3e-07 31.4 0.1 12.2 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04814.1 - 6.5e-26 90.5 3.5 5.2e-05 23.5 0.0 9.9 4 3 2 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 CCM04814.1 - 1.2e-19 70.6 0.3 2.1e-19 69.8 0.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 CCM04814.1 - 2.4e-06 26.7 5.0 0.57 9.1 0.1 6.2 3 2 3 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CCM04814.1 - 5.4e-06 25.3 4.3 1 7.9 0.0 4.6 3 2 0 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 CCM04814.1 - 0.00044 19.7 0.0 4.8 6.4 0.0 4.0 4 1 0 4 4 4 2 WD40-like domain Nucleoporin_N PF08801.11 CCM04814.1 - 0.0018 17.1 2.1 0.59 8.8 0.0 4.2 3 2 1 5 5 5 1 Nup133 N terminal like PALB2_WD40 PF16756.5 CCM04814.1 - 0.0089 15.0 0.8 1.4 7.8 0.0 3.5 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain RAB3GAP2_N PF14655.6 CCM04814.1 - 0.012 14.9 0.2 0.72 9.0 0.0 3.1 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Hira PF07569.11 CCM04814.1 - 0.056 13.2 0.6 7.8 6.2 0.1 3.5 3 0 0 3 3 3 0 TUP1-like enhancer of split eIF2A PF08662.11 CCM04814.1 - 0.087 12.7 0.1 5.6 6.8 0.0 3.4 3 1 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A DPBB_1 PF03330.18 CCM04815.1 - 7e-07 29.4 0.0 1.8e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Lytic transglycolase Cys_Met_Meta_PP PF01053.20 CCM04816.1 - 9.2e-55 185.7 0.0 3.5e-54 183.8 0.0 1.9 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Acyltransferase PF01553.21 CCM04817.1 - 0.077 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Acyltransferase SNARE_assoc PF09335.11 CCM04818.1 - 2.4e-15 57.1 13.0 1.4e-14 54.6 7.4 2.8 3 0 0 3 3 3 2 SNARE associated Golgi protein Alg6_Alg8 PF03155.15 CCM04819.1 - 5.4e-166 553.3 33.1 7.4e-166 552.9 33.1 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Syntaxin-18_N PF10496.9 CCM04819.1 - 1.7e-13 50.6 0.3 7.5e-13 48.5 0.3 2.2 1 1 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 CCM04819.1 - 3.9e-05 23.6 0.7 0.00021 21.2 0.1 2.4 2 0 0 2 2 2 1 SNARE domain VMA21 PF09446.10 CCM04820.1 - 1.2e-12 47.8 6.8 1.8e-12 47.2 6.8 1.3 1 0 0 1 1 1 1 VMA21-like domain DUF973 PF06157.11 CCM04820.1 - 0.009 15.1 0.5 0.011 14.8 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF973) Phage_holin_3_6 PF07332.11 CCM04820.1 - 0.0095 16.0 1.5 0.0097 15.9 1.5 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III SLATT_3 PF18184.1 CCM04820.1 - 0.078 13.1 0.4 0.1 12.8 0.4 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 3 Ribonuc_red_sm PF00268.21 CCM04821.1 - 1.8e-122 408.2 0.1 2.3e-122 407.9 0.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 CCM04821.1 - 0.15 12.9 0.0 0.34 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) Ribonuc_red_sm PF00268.21 CCM04822.1 - 2.3e-117 391.4 2.9 2.8e-117 391.2 2.9 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain MMR_HSR1_Xtn PF16897.5 CCM04823.1 - 1.2e-33 115.2 5.1 1.8e-31 108.3 4.2 2.8 2 1 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 CCM04823.1 - 7.5e-25 86.8 0.1 1.3e-24 86.0 0.1 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 CCM04823.1 - 1.3e-20 73.6 0.2 3.6e-20 72.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CCM04823.1 - 4.4e-08 32.8 0.0 9.8e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 CCM04823.1 - 0.014 14.4 0.2 0.032 13.2 0.2 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 CCM04823.1 - 0.024 14.7 0.5 11 6.0 0.4 2.7 1 1 1 2 2 2 0 Dynamin family Mor PF08765.11 CCM04823.1 - 0.027 14.5 0.1 0.092 12.7 0.0 1.9 2 0 0 2 2 2 0 Mor transcription activator family Glyco_hydro_66 PF13199.6 CCM04823.1 - 0.058 12.0 0.0 0.089 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 NB-ARC PF00931.22 CCM04823.1 - 0.13 11.4 0.0 0.35 10.0 0.0 1.8 1 1 0 1 1 1 0 NB-ARC domain KCH PF16944.5 CCM04824.1 - 1.3e-86 290.5 18.1 6.5e-57 193.2 6.3 2.0 2 0 0 2 2 2 2 Fungal potassium channel UPF0242 PF06785.11 CCM04824.1 - 0.27 11.3 0.0 0.27 11.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Peptidase_S24 PF00717.23 CCM04825.1 - 3.9e-10 39.5 0.1 8.5e-10 38.5 0.1 1.6 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CCM04825.1 - 0.0041 16.9 0.0 1 9.2 0.0 2.8 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 ATE_C PF04377.15 CCM04826.1 - 8.3e-31 107.4 0.3 1.2e-30 106.9 0.3 1.2 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus WD40 PF00400.32 CCM04827.1 - 0.005 17.7 0.2 1.6 9.8 0.0 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04827.1 - 0.051 13.9 0.0 0.26 11.6 0.0 2.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 CCM04827.1 - 0.067 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) DUF839 PF05787.13 CCM04827.1 - 0.19 10.9 0.0 0.28 10.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF839) XRCC4 PF06632.12 CCM04828.1 - 4.9 5.9 10.9 7.7 5.3 10.9 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 EF-hand_7 PF13499.6 CCM04829.1 - 4.3e-27 94.4 5.4 5.5e-18 65.2 0.8 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 CCM04829.1 - 9.7e-25 84.2 10.2 3.2e-08 32.6 0.1 4.9 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 CCM04829.1 - 2.8e-21 73.6 7.1 1.6e-06 27.5 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 CCM04829.1 - 4.5e-14 51.2 7.5 0.00028 20.2 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 CCM04829.1 - 5.1e-12 45.5 8.4 8.3e-05 22.4 0.8 3.6 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 CCM04829.1 - 2e-06 27.7 3.0 0.25 11.3 0.0 3.8 2 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CCM04829.1 - 8.9e-05 22.8 1.8 0.1 12.9 0.2 3.5 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CCM04829.1 - 0.013 15.8 1.2 0.43 10.9 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain Pan3_PK PF18101.1 CCM04829.1 - 0.033 14.2 0.1 0.063 13.3 0.1 1.4 1 0 0 1 1 1 0 Pan3 Pseudokinase domain DUF1298 PF06974.13 CCM04829.1 - 0.21 11.5 0.0 0.36 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1298) p25-alpha PF05517.12 CCM04829.1 - 0.24 11.6 1.8 17 5.5 0.1 2.4 1 1 0 2 2 2 0 p25-alpha Caleosin PF05042.13 CCM04829.1 - 0.32 10.9 5.2 8.3 6.3 0.0 3.4 3 1 0 4 4 4 0 Caleosin related protein EMC3_TMCO1 PF01956.16 CCM04830.1 - 1.3e-46 158.4 0.0 1.9e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Sec63 PF02889.16 CCM04831.1 - 1.2e-69 234.4 0.0 1.7e-69 233.9 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 CCM04831.1 - 1.1e-28 100.2 0.2 1.7e-11 44.2 0.0 4.2 3 1 1 4 4 4 3 DEAD/DEAH box helicase ResIII PF04851.15 CCM04831.1 - 2.9e-12 46.9 0.0 0.0035 17.4 0.0 3.6 2 1 1 3 3 3 3 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CCM04831.1 - 2.3e-07 31.2 0.0 0.00019 21.7 0.0 3.8 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CCM04831.1 - 6.8e-07 29.6 0.6 0.021 15.1 0.6 3.5 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CCM04831.1 - 2.8e-05 23.9 0.2 0.045 13.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 CCM04831.1 - 0.00012 22.5 0.1 0.037 14.4 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CCM04831.1 - 0.00039 20.2 1.4 3.1 7.5 0.1 3.8 3 1 0 3 3 3 2 IstB-like ATP binding protein T2SSE PF00437.20 CCM04831.1 - 0.00088 18.4 0.0 0.33 10.0 0.0 2.7 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_7 PF12775.7 CCM04831.1 - 0.0012 18.4 0.2 0.86 9.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_11 PF13086.6 CCM04831.1 - 0.0058 16.4 0.0 0.35 10.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CCM04831.1 - 0.0067 16.0 1.5 3.9 7.0 0.3 4.3 4 1 0 4 4 4 1 AAA domain AAA_19 PF13245.6 CCM04831.1 - 0.014 15.7 0.3 1 9.7 0.2 2.9 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 CCM04831.1 - 0.048 13.1 0.0 11 5.4 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein DUF87 PF01935.17 CCM04831.1 - 0.059 13.5 0.6 1.1 9.3 0.0 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain TniB PF05621.11 CCM04831.1 - 0.11 11.9 0.2 1.3 8.4 0.1 2.6 2 1 0 2 2 2 0 Bacterial TniB protein Aminotran_1_2 PF00155.21 CCM04832.1 - 4.9e-64 216.8 0.0 5.7e-64 216.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCM04832.1 - 1.9e-06 27.5 0.0 3.4e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CCM04832.1 - 1.8e-05 23.4 0.0 4.1e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCM04832.1 - 0.00064 18.8 0.0 0.0088 15.0 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CCM04832.1 - 0.0012 18.2 0.0 0.0024 17.2 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase Ank_2 PF12796.7 CCM04833.1 - 5.3e-33 113.5 0.0 1.5e-15 57.5 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM04833.1 - 1.4e-32 111.3 0.5 4.4e-10 39.6 0.0 4.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCM04833.1 - 3.9e-31 107.0 5.6 1.7e-13 50.8 0.5 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM04833.1 - 1.9e-24 83.1 0.2 0.00013 22.1 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 CCM04833.1 - 4.8e-22 77.4 0.4 0.00039 20.7 0.1 5.2 5 0 0 5 5 5 4 Ankyrin repeat FYVE PF01363.21 CCM04833.1 - 0.00013 22.0 0.7 0.00013 22.0 0.7 2.3 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_11 PF17123.5 CCM04833.1 - 0.0039 16.9 2.0 0.0039 16.9 2.0 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 CCM04833.1 - 0.022 15.1 3.8 0.072 13.4 1.5 2.5 2 0 0 2 2 2 0 Ring finger domain RXT2_N PF08595.11 CCM04834.1 - 0.13 12.3 2.1 0.25 11.4 2.1 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Cir_N PF10197.9 CCM04834.1 - 9.3 6.5 10.3 1.2 9.4 4.1 2.4 2 0 0 2 2 2 0 N-terminal domain of CBF1 interacting co-repressor CIR PI31_Prot_N PF11566.8 CCM04835.1 - 3.7e-46 156.9 0.0 4.5e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 CCM04835.1 - 4.2e-12 47.1 18.3 4.2e-12 47.1 18.3 3.3 3 0 0 3 3 3 1 PI31 proteasome regulator DEAD PF00270.29 CCM04836.1 - 2.9e-52 177.0 0.0 4.9e-51 173.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM04836.1 - 7.9e-27 93.8 0.0 2.9e-26 92.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM04836.1 - 0.0011 19.0 0.0 0.0063 16.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sugar_tr PF00083.24 CCM04837.1 - 4.4e-107 358.7 23.5 5.3e-107 358.5 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM04837.1 - 5.9e-25 87.9 49.7 4.8e-21 75.1 22.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily UL42 PF17638.2 CCM04837.1 - 0.3 11.1 2.3 0.5 10.3 0.1 2.3 2 0 0 2 2 2 0 HCMV UL42 DUF3341 PF11821.8 CCM04837.1 - 0.46 10.1 3.7 1.3 8.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3341) CDT1_C PF16679.5 CCM04838.1 - 2.8e-14 53.3 0.1 6.3e-14 52.2 0.1 1.7 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain DUF908 PF06012.12 CCM04838.1 - 2.1 7.7 13.1 5.9 6.2 13.0 1.7 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) zf-MYND PF01753.18 CCM04839.1 - 0.0017 18.4 3.0 0.0017 18.4 3.0 2.0 2 0 0 2 2 2 1 MYND finger DUF5127 PF17168.4 CCM04840.1 - 6.9e-68 228.8 4.5 9.2e-68 228.4 4.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CCM04840.1 - 2e-21 76.4 0.8 4e-20 72.2 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4965) DUF4964 PF16334.5 CCM04840.1 - 0.0042 16.6 0.2 0.013 15.0 0.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4964) DUF1793 PF08760.11 CCM04841.1 - 6.2e-32 111.3 0.7 8.8e-32 110.8 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 CCM04841.1 - 0.015 15.0 0.7 0.032 13.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4965) MFS_1 PF07690.16 CCM04842.1 - 1.8e-29 102.8 16.5 3.3e-29 101.9 14.0 1.9 1 1 0 2 2 2 1 Major Facilitator Superfamily Ceramidase PF05875.12 CCM04842.1 - 0.0091 15.4 1.8 0.017 14.5 1.8 1.3 1 0 0 1 1 1 1 Ceramidase Ytp1 PF10355.9 CCM04843.1 - 1.6e-106 355.6 8.0 2.2e-106 355.1 8.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CCM04843.1 - 4.7e-13 48.8 2.5 5.6e-13 48.6 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) ChaC PF04752.12 CCM04844.1 - 8.5e-53 179.1 0.0 9.6e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein UbiA PF01040.18 CCM04845.1 - 2.3e-53 181.1 14.4 2.7e-53 180.9 14.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Rho_GDI PF02115.17 CCM04846.1 - 6.4e-58 195.7 0.0 7.3e-58 195.5 0.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor CopC PF04234.12 CCM04846.1 - 0.062 14.3 0.1 0.17 13.0 0.1 1.8 1 1 0 1 1 1 0 CopC domain PBP_dimer PF03717.15 CCM04846.1 - 0.091 13.1 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Penicillin-binding Protein dimerisation domain MbeD_MobD PF04899.12 CCM04847.1 - 0.084 13.0 1.0 0.89 9.7 0.0 2.5 1 1 1 2 2 2 0 MbeD/MobD like Nsp1_C PF05064.13 CCM04848.1 - 4.4e-32 110.3 0.1 7.6e-32 109.5 0.1 1.3 1 0 0 1 1 1 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 CCM04848.1 - 1.3e-13 51.6 159.6 2.1e-06 28.5 34.4 7.0 1 1 6 7 7 7 5 Nucleoporin FG repeat region FlaC_arch PF05377.11 CCM04848.1 - 0.63 10.5 3.4 32 5.0 1.2 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) CENP-Q PF13094.6 CCM04848.1 - 0.9 9.7 3.3 3.4 7.9 3.4 2.0 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Nup88 PF10168.9 CCM04850.1 - 5.6e-23 80.7 0.7 5.2e-12 44.4 0.0 3.1 2 1 1 3 3 3 2 Nuclear pore component Nup54 PF13874.6 CCM04850.1 - 9.6e-05 22.5 6.0 9.6e-05 22.5 6.0 1.8 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 ABC_tran_Xtn PF12848.7 CCM04850.1 - 0.13 12.3 3.2 0.34 11.0 3.2 1.7 1 0 0 1 1 1 0 ABC transporter ANAPC4_WD40 PF12894.7 CCM04850.1 - 0.17 12.2 0.0 22 5.5 0.0 2.5 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain MobL PF18555.1 CCM04850.1 - 0.56 9.4 4.4 0.84 8.8 4.4 1.1 1 0 0 1 1 1 0 MobL relaxases Proteasome PF00227.26 CCM04851.1 - 1.1e-46 158.7 0.0 1.4e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CCM04851.1 - 2e-13 49.7 0.1 3.3e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CSN8_PSD8_EIF3K PF10075.9 CCM04852.1 - 3.4e-30 104.9 0.1 5.2e-30 104.3 0.1 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 CCM04852.1 - 1.9e-06 27.5 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP family Proteasome PF00227.26 CCM04853.1 - 3.3e-45 153.9 0.1 3.7e-45 153.7 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF448 PF04296.13 CCM04854.1 - 0.02 14.7 0.0 0.085 12.7 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF448) GFO_IDH_MocA PF01408.22 CCM04855.1 - 9.6e-19 68.4 0.3 1.5e-18 67.7 0.3 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCM04855.1 - 2.7e-07 30.6 0.0 1.7e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Sacchrp_dh_NADP PF03435.18 CCM04855.1 - 0.016 15.4 0.5 0.045 14.0 0.3 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CCM04855.1 - 0.025 15.2 0.1 0.069 13.7 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 CCM04855.1 - 0.045 13.3 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 CCM04855.1 - 0.088 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF1793 PF08760.11 CCM04856.1 - 4e-33 115.2 1.3 5.5e-33 114.8 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) PTP_tm PF18861.1 CCM04856.1 - 0.0081 16.2 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J VPDSG-CTERM PF18205.1 CCM04856.1 - 0.024 14.5 3.0 0.068 13.0 3.0 1.8 1 0 0 1 1 1 0 VPDSG-CTERM motif DUF202 PF02656.15 CCM04856.1 - 1.8 9.1 5.9 28 5.2 5.9 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Gram_pos_anchor PF00746.21 CCM04856.1 - 2.3 8.2 5.5 0.79 9.7 1.7 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF5127 PF17168.4 CCM04857.1 - 3.4e-55 187.3 3.1 3.3e-27 95.7 0.2 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CCM04857.1 - 5.9e-18 65.1 0.3 2.2e-17 63.3 0.0 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4965) DUF4964 PF16334.5 CCM04857.1 - 4.7e-08 32.5 0.0 1.3e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) PI_PP_I PF18363.1 CCM04857.1 - 0.13 12.5 0.0 0.35 11.1 0.0 1.7 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain adh_short PF00106.25 CCM04858.1 - 2.5e-38 131.5 0.0 3.7e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04858.1 - 1.4e-26 93.5 0.0 1.9e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04858.1 - 4.4e-09 36.5 0.0 1.2e-08 35.1 0.0 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM04858.1 - 6.3e-05 22.9 0.5 0.00011 22.2 0.5 1.7 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CCM04858.1 - 0.00057 19.1 0.1 0.001 18.3 0.1 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CCM04858.1 - 0.0067 15.9 0.2 0.027 13.9 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Apt1 PF10351.9 CCM04859.1 - 0.075 11.9 14.4 0.15 10.9 14.4 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hid1 PF12722.7 CCM04859.1 - 2 6.5 7.9 2.6 6.1 7.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CCM04859.1 - 2.2 5.3 16.8 2.9 4.9 16.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer cNMP_binding PF00027.29 CCM04860.1 - 1.1e-32 112.0 0.3 4.4e-16 58.7 0.1 3.1 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 CCM04860.1 - 4.5e-12 45.4 1.1 1.9e-11 43.4 0.4 2.2 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit ubiquitin PF00240.23 CCM04861.1 - 1.6e-05 24.6 0.0 2.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 CCM04861.1 - 0.12 12.9 0.0 0.25 11.9 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain UPRTase PF14681.6 CCM04862.1 - 2.9e-70 235.9 0.0 3.3e-70 235.7 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CCM04862.1 - 0.0058 16.2 0.0 0.0081 15.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF3263 PF11662.8 CCM04862.1 - 0.099 12.5 0.1 19 5.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3263) FAD_binding_1 PF00667.20 CCM04863.1 - 1.3e-51 175.4 0.0 1.8e-51 174.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CCM04863.1 - 1.8e-08 35.0 0.0 4.2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 CCM04863.1 - 0.064 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II FAD_binding_6 PF00970.24 CCM04863.1 - 0.099 13.0 0.0 0.32 11.4 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain POR PF01558.18 CCM04863.1 - 0.13 12.3 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase NUDIX PF00293.28 CCM04864.1 - 1.1e-11 44.9 0.1 4.1e-11 43.1 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain GFO_IDH_MocA PF01408.22 CCM04865.1 - 2.5e-21 76.7 0.0 4.5e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCM04865.1 - 1.1e-07 31.9 0.0 1.9e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 CCM04865.1 - 0.045 14.4 0.0 0.077 13.7 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CCM04865.1 - 0.06 13.8 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CoA_binding PF02629.19 CCM04865.1 - 0.16 12.7 0.0 0.38 11.5 0.0 1.6 1 0 0 1 1 1 0 CoA binding domain GFO_IDH_MocA PF01408.22 CCM04866.1 - 3.4e-19 69.8 0.1 6.4e-19 68.9 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCM04866.1 - 1.8e-09 37.6 0.0 3.4e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 CCM04866.1 - 0.0014 19.3 0.1 0.0023 18.6 0.1 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CCM04866.1 - 0.019 15.4 0.0 0.031 14.7 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain efThoc1 PF11957.8 CCM04866.1 - 0.14 10.8 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor DapB_N PF01113.20 CCM04866.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Methyltransf_8 PF05148.15 CCM04867.1 - 5.6e-61 206.2 0.0 1.5e-31 109.9 0.0 2.1 2 0 0 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CCM04867.1 - 3e-06 27.8 0.1 4e-05 24.2 0.1 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM04867.1 - 0.00014 22.4 0.3 0.21 12.3 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 CCM04867.1 - 0.00078 19.3 0.0 0.12 12.2 0.0 2.6 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CCM04867.1 - 0.0036 17.1 0.0 0.0087 15.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain AAA_22 PF13401.6 CCM04868.1 - 9.6e-06 25.9 0.0 0.3 11.3 0.0 3.0 1 1 0 2 2 2 2 AAA domain Zot PF05707.12 CCM04868.1 - 7.6e-05 22.4 0.0 0.00046 19.9 0.0 1.9 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA PF00004.29 CCM04868.1 - 0.0025 18.2 0.1 0.14 12.6 0.0 2.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 CCM04868.1 - 0.019 15.1 0.0 0.095 12.8 0.0 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_16 PF13191.6 CCM04868.1 - 0.022 15.1 2.3 6.5 7.1 0.1 2.8 2 1 1 3 3 3 0 AAA ATPase domain Zeta_toxin PF06414.12 CCM04868.1 - 0.12 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Ribosomal_S3Ae PF01015.18 CCM04869.1 - 1.7e-94 315.1 2.1 2.1e-94 314.8 2.1 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 CCM04869.1 - 0.093 12.3 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Autophagy_act_C PF03987.15 CCM04870.1 - 2.2e-18 66.6 1.4 4.4e-18 65.6 1.4 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Thiolase_N PF00108.23 CCM04871.1 - 4.7e-84 281.8 1.7 6.8e-84 281.3 1.7 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCM04871.1 - 5.6e-40 135.8 1.5 5.6e-40 135.8 1.5 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCM04871.1 - 0.0075 15.9 4.8 0.079 12.5 3.3 2.4 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Asparaginase_C PF17763.1 CCM04871.1 - 0.02 15.1 1.3 0.12 12.6 0.1 2.4 2 0 0 2 2 2 0 Glutaminase/Asparaginase C-terminal domain ACP_syn_III_C PF08541.10 CCM04871.1 - 0.058 13.6 0.1 0.2 11.8 0.1 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal TraW_N PF12477.8 CCM04871.1 - 0.11 12.5 0.7 0.52 10.3 0.3 2.4 2 0 0 2 2 2 0 Sex factor F TraW protein N terminal ACP_syn_III PF08545.10 CCM04871.1 - 9.2 6.2 7.2 2 8.3 0.9 2.8 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.16 CCM04872.1 - 4.2e-33 114.7 15.3 4.2e-33 114.7 15.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3021 PF11457.8 CCM04872.1 - 0.036 14.4 0.5 0.036 14.4 0.5 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF3021) Sugarporin_N PF11471.8 CCM04872.1 - 0.5 10.4 1.7 0.8 9.7 0.1 2.2 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension BTB PF00651.31 CCM04873.1 - 0.0027 17.9 0.0 0.02 15.1 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain SOG2 PF10428.9 CCM04873.1 - 0.0042 16.3 13.9 0.0042 16.3 13.9 1.8 2 0 0 2 2 2 1 RAM signalling pathway protein MFS_1 PF07690.16 CCM04874.1 - 2e-19 69.8 8.0 2.4e-19 69.5 8.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 CCM04875.1 - 1.1e-06 27.9 3.9 1.2e-06 27.7 3.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3464 PF11947.8 CCM04875.1 - 0.3 10.8 0.5 0.46 10.2 0.5 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SID-1_RNA_chan PF13965.6 CCM04876.1 - 0.18 10.2 0.1 0.23 9.8 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DIOX_N PF14226.6 CCM04877.1 - 1.6e-24 86.9 0.2 2.5e-24 86.3 0.2 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM04877.1 - 1.1e-16 61.2 0.0 2.2e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Spermine_synth PF01564.17 CCM04878.1 - 0.00062 19.2 0.0 0.0019 17.6 0.0 1.7 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Alpha-amylase_C PF02806.18 CCM04879.1 - 3.2e-25 88.4 0.1 8.4e-25 87.1 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 CCM04879.1 - 1.2e-16 60.8 0.0 3.7e-16 59.2 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CCM04879.1 - 1.2e-13 51.3 0.1 2e-10 40.7 0.2 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain TFR_dimer PF04253.15 CCM04880.1 - 1.8e-20 73.3 0.3 7.3e-18 64.8 0.0 2.6 2 0 0 2 2 2 2 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 CCM04880.1 - 3.6e-15 56.2 0.0 1.4e-14 54.2 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CCM04880.1 - 8.3e-09 35.4 0.7 1.7e-08 34.3 0.2 1.9 2 0 0 2 2 2 1 PA domain MADF_DNA_bdg PF10545.9 CCM04880.1 - 2.4 8.6 6.0 3.2 8.1 1.3 2.6 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Polysacc_deac_1 PF01522.21 CCM04881.1 - 8.8e-20 70.8 0.1 2.2e-19 69.6 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase ATG11 PF10377.9 CCM04884.1 - 1e-31 109.7 1.2 1.6e-31 109.1 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein 11 betaPIX_CC PF16523.5 CCM04884.1 - 5.3 6.9 14.0 0.75 9.7 5.1 3.8 3 1 1 4 4 4 0 betaPIX coiled coil Sugar_tr PF00083.24 CCM04885.1 - 4.5e-66 223.6 18.5 5.1e-66 223.4 18.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM04885.1 - 1.9e-11 43.5 17.1 1.9e-11 43.5 17.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily ADH_zinc_N_2 PF13602.6 CCM04886.1 - 0.004 18.2 0.0 0.0044 18.1 0.0 1.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CCM04886.1 - 0.033 14.2 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM04887.1 - 1e-27 96.2 0.8 1.6e-27 95.6 0.8 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM04887.1 - 1.1e-08 35.2 0.4 2.3e-08 34.1 0.4 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TTC5_OB PF16669.5 CCM04887.1 - 0.0077 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain AlaDh_PNT_C PF01262.21 CCM04887.1 - 0.13 11.5 0.2 0.22 10.8 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 CCM04887.1 - 0.2 11.1 0.2 0.2 11.1 0.2 1.7 2 0 0 2 2 2 0 short chain dehydrogenase p450 PF00067.22 CCM04888.1 - 7.5e-88 295.3 0.0 1.3e-87 294.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 CCM04888.1 - 8e-23 81.2 0.2 3.2e-22 79.3 0.0 2.1 3 0 0 3 3 3 1 Flavodoxin FAD_binding_1 PF00667.20 CCM04888.1 - 1.8e-22 80.0 0.0 2.8e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CCM04888.1 - 1.1e-08 35.7 0.0 2.5e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 CCM04888.1 - 0.051 13.8 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 Flavodoxin domain SKG6 PF08693.10 CCM04889.1 - 0.00058 19.2 0.8 0.001 18.4 0.8 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CD34_antigen PF06365.12 CCM04889.1 - 0.0057 16.3 0.0 0.0092 15.6 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family Phage_holin_2_1 PF04971.12 CCM04889.1 - 0.026 14.5 1.4 0.03 14.3 0.0 1.9 2 0 0 2 2 2 0 Bacteriophage P21 holin S EphA2_TM PF14575.6 CCM04889.1 - 0.04 14.8 0.0 0.074 13.9 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 CCM04889.1 - 0.066 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF2207 PF09972.9 CCM04889.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Gram_pos_anchor PF00746.21 CCM04889.1 - 0.18 11.8 1.2 0.6 10.1 1.2 2.0 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Yip1 PF04893.17 CCM04889.1 - 0.34 10.6 3.3 0.78 9.4 0.0 2.4 2 1 0 2 2 2 0 Yip1 domain Gly-zipper_Omp PF13488.6 CCM04889.1 - 0.55 10.3 12.6 1.9 8.6 12.6 1.9 1 0 0 1 1 1 0 Glycine zipper FMO-like PF00743.19 CCM04891.1 - 1.9e-34 119.0 0.0 7.9e-29 100.5 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCM04891.1 - 1.9e-11 43.7 0.0 3.6e-09 36.3 0.0 2.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM04891.1 - 1.4e-10 40.9 0.2 9.6e-09 34.9 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CCM04891.1 - 0.00022 21.2 0.5 1.4 8.9 0.0 4.0 4 0 0 4 4 4 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CCM04891.1 - 0.00048 19.4 0.0 0.0024 17.1 0.0 2.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CCM04891.1 - 0.023 14.0 0.3 0.091 12.0 0.0 1.9 2 0 0 2 2 2 0 Thi4 family Sec20 PF03908.13 CCM04892.1 - 3.2e-18 65.4 1.6 3.2e-18 65.4 1.6 2.6 3 1 0 3 3 3 1 Sec20 HBS1_N PF08938.10 CCM04892.1 - 0.08 13.2 3.7 1.7 9.0 0.0 3.7 4 0 0 4 4 4 0 HBS1 N-terminus Syntaxin_2 PF14523.6 CCM04892.1 - 0.25 11.7 6.1 0.18 12.2 4.1 1.8 2 0 0 2 2 2 0 Syntaxin-like protein Apq12 PF12716.7 CCM04892.1 - 0.64 10.0 5.0 1.3 9.0 5.0 1.5 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis Mito_carr PF00153.27 CCM04893.1 - 1.4e-52 175.6 5.9 1.7e-20 72.7 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CCM04893.1 - 0.0018 17.5 0.0 0.3 10.2 0.0 2.3 2 0 0 2 2 2 2 Gammaproteobacterial serine protease Tim17 PF02466.19 CCM04893.1 - 0.19 12.1 3.6 6.9 7.1 0.5 3.0 2 2 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family ADH_zinc_N PF00107.26 CCM04894.1 - 4.2e-14 52.6 0.0 8e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM04894.1 - 3.4e-09 36.5 0.0 5.4e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CCM04894.1 - 0.013 16.6 0.0 0.021 15.8 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase PHD PF00628.29 CCM04895.1 - 9.5e-09 35.0 2.3 1.8e-08 34.1 2.3 1.5 1 0 0 1 1 1 1 PHD-finger Chromo PF00385.24 CCM04895.1 - 0.00063 19.6 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Sugar_tr PF00083.24 CCM04896.1 - 1.2e-72 245.2 25.3 1.6e-72 244.9 25.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM04896.1 - 1.5e-24 86.6 51.0 5.7e-24 84.7 28.0 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Rho_N PF07498.12 CCM04896.1 - 0.0011 18.9 0.4 0.0026 17.7 0.4 1.6 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain MAP7 PF05672.11 CCM04896.1 - 0.004 16.9 6.4 0.0094 15.7 6.4 1.5 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family Armet PF10208.9 CCM04896.1 - 0.034 14.1 0.1 8.1 6.4 0.1 2.3 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding zf-HIT PF04438.16 CCM04896.1 - 0.12 12.3 1.0 2.2 8.2 0.1 2.2 2 0 0 2 2 2 0 HIT zinc finger SAP30_Sin3_bdg PF13867.6 CCM04896.1 - 0.14 12.5 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-C3HC4_3 PF13920.6 CCM04896.1 - 0.65 9.9 4.3 0.082 12.8 0.4 1.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RSN1_7TM PF02714.15 CCM04897.1 - 2.8e-81 272.8 23.0 4.1e-81 272.3 23.0 1.2 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCM04897.1 - 1.8e-25 90.2 0.8 5.7e-17 62.5 0.0 2.9 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CCM04897.1 - 4e-25 88.4 1.7 4e-25 88.4 1.7 2.2 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 CCM04897.1 - 1e-11 44.8 0.0 2.2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter Anoctamin PF04547.12 CCM04897.1 - 0.007 15.3 0.0 0.007 15.3 0.0 2.2 2 1 0 3 3 3 1 Calcium-activated chloride channel Orf78 PF06024.12 CCM04897.1 - 0.083 13.2 0.1 0.67 10.3 0.0 2.5 2 0 0 2 2 2 0 Orf78 (ac78) DUF2441 PF10386.9 CCM04899.1 - 0.0071 16.3 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2441) F-box-like PF12937.7 CCM04900.1 - 0.0034 17.2 0.1 0.0075 16.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like Lactamase_B PF00753.27 CCM04901.1 - 3.2e-09 37.1 1.7 8.7e-09 35.7 1.7 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Sugar_tr PF00083.24 CCM04904.1 - 8.7e-25 87.5 6.8 9.8e-25 87.3 6.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter SH3_1 PF00018.28 CCM04906.1 - 3.5e-14 52.1 0.0 6.5e-14 51.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCM04906.1 - 2.3e-11 43.4 0.1 4.6e-11 42.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CCM04906.1 - 1e-10 41.1 0.0 2.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 CCM04906.1 - 1.5e-07 31.4 0.1 0.00062 19.8 0.0 2.6 2 0 0 2 2 2 2 WW domain Skp1_POZ PF03931.15 CCM04906.1 - 0.097 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Apolipoprotein PF01442.18 CCM04906.1 - 2.9 7.7 8.2 0.87 9.4 3.8 2.3 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain RasGEF PF00617.19 CCM04907.1 - 6.6e-51 173.0 0.3 9.7e-51 172.5 0.3 1.2 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCM04907.1 - 1.4e-19 70.3 0.0 7e-19 68.0 0.0 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif HAD_2 PF13419.6 CCM04909.1 - 2.3e-15 57.2 0.0 2.3e-10 40.9 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCM04909.1 - 1.7e-11 44.8 0.0 5.2e-11 43.2 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM04909.1 - 3.1e-05 23.9 0.0 9.5e-05 22.4 0.0 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like p450 PF00067.22 CCM04910.1 - 7.2e-14 51.4 0.0 1e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 BHD_3 PF10405.9 CCM04912.1 - 2.8e-29 101.4 0.1 5.5e-29 100.4 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.15 CCM04912.1 - 3.3e-23 82.0 0.0 1.1e-22 80.2 0.0 2.0 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_1 PF10403.9 CCM04912.1 - 3.4e-19 68.4 0.0 7.4e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 CCM04912.1 - 2.3e-18 66.9 1.0 2.3e-18 66.9 1.0 5.3 5 2 0 5 5 5 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 CCM04912.1 - 4.3e-06 27.2 0.0 5.5e-05 23.6 0.0 2.6 2 0 0 2 2 2 1 Transglutaminase-like superfamily GCD14 PF08704.10 CCM04913.1 - 1.4e-80 270.6 0.2 9.5e-58 195.8 0.0 2.9 2 1 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 CCM04913.1 - 0.07 12.9 0.0 0.14 11.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain PAS_3 PF08447.12 CCM04914.1 - 1.1e-08 35.2 0.0 6.6e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 CCM04914.1 - 3.5e-05 23.8 0.0 0.00033 20.6 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 CCM04914.1 - 0.00055 20.0 0.0 0.11 12.7 0.0 2.2 2 0 0 2 2 2 2 PAS domain PAS_9 PF13426.7 CCM04914.1 - 0.0085 16.3 0.0 0.25 11.6 0.0 2.2 2 0 0 2 2 2 1 PAS domain p450 PF00067.22 CCM04915.1 - 1.8e-49 168.8 0.0 2.6e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DEAD PF00270.29 CCM04917.1 - 1.2e-17 64.3 0.0 1.9e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM04917.1 - 4.4e-13 49.6 0.0 2.3e-10 40.8 0.0 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CCM04917.1 - 2.5e-10 40.9 0.1 9.7e-10 39.0 0.1 2.1 1 0 0 1 1 1 1 RecQ zinc-binding CN_hydrolase PF00795.22 CCM04918.1 - 1.2e-12 47.7 0.0 3.2e-11 43.1 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase 3Beta_HSD PF01073.19 CCM04919.1 - 1.8e-60 204.3 0.0 2.9e-57 193.8 0.0 2.2 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CCM04919.1 - 1e-29 103.7 0.1 1.4e-29 103.3 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM04919.1 - 8.4e-17 61.6 0.2 1e-13 51.4 0.1 2.7 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCM04919.1 - 1.9e-11 43.6 0.0 5.6e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CCM04919.1 - 3.5e-11 43.3 0.0 5.3e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CCM04919.1 - 6.2e-11 41.9 0.1 9.1e-11 41.4 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CCM04919.1 - 3e-06 26.6 0.1 1.3e-05 24.5 0.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CCM04919.1 - 0.073 13.0 0.2 0.7 9.8 0.1 2.2 1 1 1 2 2 2 0 KR domain Mito_carr PF00153.27 CCM04921.1 - 3.5e-58 193.5 0.1 2.6e-24 85.0 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Na_H_Exchanger PF00999.21 CCM04922.1 - 0.017 13.9 3.1 0.022 13.5 3.1 1.1 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family Stevor PF17410.2 CCM04922.1 - 0.41 10.2 6.1 0.59 9.6 6.1 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Carn_acyltransf PF00755.20 CCM04923.1 - 7.2e-193 642.4 0.0 8.2e-193 642.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Linker_histone PF00538.19 CCM04925.1 - 9e-08 32.4 0.0 2e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 linker histone H1 and H5 family zf-CCCH PF00642.24 CCM04926.1 - 2.4e-22 78.3 23.4 2e-08 33.9 4.1 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCM04926.1 - 6.7e-19 67.3 26.3 3.2e-06 27.0 5.2 3.4 3 0 0 3 3 3 3 Zinc finger domain Torus PF16131.5 CCM04926.1 - 3.1e-13 50.4 9.3 0.00049 20.8 0.1 3.3 3 0 0 3 3 3 3 Torus domain zf-CCCH_4 PF18044.1 CCM04926.1 - 9.1e-11 41.3 28.3 7.5e-05 22.4 0.7 3.8 4 0 0 4 4 4 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CCM04926.1 - 1.5e-06 28.4 22.2 0.013 15.9 0.8 3.6 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 CCM04926.1 - 0.1 12.8 8.6 0.93 9.7 0.7 3.0 3 0 0 3 3 3 0 Zinc-finger containing family Heme_oxygenase PF01126.20 CCM04927.1 - 6.9e-37 127.2 0.0 9.7e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 Heme oxygenase Asp PF00026.23 CCM04929.1 - 2.2e-47 162.0 15.0 4.3e-47 161.1 15.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM04929.1 - 1.1e-07 32.3 8.6 0.00019 21.7 0.5 3.4 1 1 2 3 3 3 2 Xylanase inhibitor N-terminal SelP_N PF04592.14 CCM04929.1 - 2.3 7.6 6.0 3.4 7.0 6.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Asp_protease_2 PF13650.6 CCM04929.1 - 3.2 8.5 11.8 0.24 12.1 1.3 3.1 3 0 0 3 3 3 0 Aspartyl protease F-box-like PF12937.7 CCM04930.1 - 0.00091 19.1 0.0 0.002 18.0 0.0 1.6 1 0 0 1 1 1 1 F-box-like BTB PF00651.31 CCM04931.1 - 6e-05 23.2 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ribosomal_S8 PF00410.19 CCM04932.1 - 1.3e-25 89.8 0.1 1.6e-25 89.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S17e PF00833.18 CCM04933.1 - 9.2e-48 161.2 0.0 1.3e-47 160.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal S17 Aldo_ket_red PF00248.21 CCM04934.1 - 7.5e-46 156.6 0.0 7.2e-37 127.2 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family PnpCD_PnpD_N PF18191.1 CCM04934.1 - 0.13 11.9 0.0 0.46 10.1 0.0 1.8 1 1 0 1 1 1 0 Hydroquinone 1,2-dioxygenase large subunit N-terminal BTB PF00651.31 CCM04935.1 - 0.0022 18.2 0.0 0.0049 17.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ribonuc_red_lgC PF02867.15 CCM04937.1 - 9.5e-183 608.5 0.0 1.2e-182 608.1 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CCM04937.1 - 5.5e-21 74.4 0.0 1.4e-20 73.0 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CCM04937.1 - 9.2e-08 32.6 0.1 3e-07 30.9 0.1 1.9 1 0 0 1 1 1 1 ATP cone domain Glyco_hydro_30 PF02055.16 CCM04938.1 - 9.4e-26 90.6 2.6 1.8e-25 89.7 2.6 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 CCM04938.1 - 9.4e-15 54.6 0.1 1.5e-14 53.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydr_30_2 PF14587.6 CCM04938.1 - 0.024 14.3 0.0 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 O-Glycosyl hydrolase family 30 Pkinase PF00069.25 CCM04939.1 - 0.0061 15.9 0.0 0.25 10.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain FA_desaturase PF00487.24 CCM04940.1 - 5.3e-23 82.2 23.2 1.7e-22 80.5 23.2 1.8 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CCM04940.1 - 0.018 15.2 0.0 0.038 14.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) Ribosomal_S19e PF01090.19 CCM04941.1 - 1.9e-57 192.8 0.0 2.2e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e F-box-like PF12937.7 CCM04942.1 - 1.1e-11 44.4 0.5 2e-10 40.4 0.2 2.7 2 0 0 2 2 2 1 F-box-like A_deaminase PF00962.22 CCM04943.1 - 3.4e-121 404.6 0.5 4.9e-121 404.1 0.5 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase TPP_enzyme_N PF02776.18 CCM04944.1 - 3.4e-36 124.4 0.1 6e-36 123.6 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 CCM04944.1 - 3.2e-16 59.3 0.0 7e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 CCM04944.1 - 1.6e-12 47.5 0.2 1e-11 44.8 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF1192 PF06698.11 CCM04944.1 - 0.11 12.5 0.3 0.11 12.5 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PUL PF08324.11 CCM04945.1 - 1.9e-39 135.6 1.4 2.7e-39 135.1 1.4 1.2 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 CCM04945.1 - 1.1e-33 116.2 0.0 2e-33 115.4 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 CCM04945.1 - 8.2e-14 51.4 0.0 1.7e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 CCM04945.1 - 1.4e-05 24.6 0.0 2.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CCM04945.1 - 2.5e-05 24.7 0.0 0.00011 22.7 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 CCM04945.1 - 0.0012 18.6 0.0 0.0051 16.5 0.0 2.0 2 1 0 2 2 2 1 Redoxin Thioredoxin_7 PF13899.6 CCM04945.1 - 0.0092 16.1 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CCM04945.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.6 1 1 0 1 1 1 0 AhpC/TSA family DUF4284 PF14112.6 CCM04946.1 - 0.11 13.4 0.2 0.28 12.1 0.2 1.7 1 0 0 1 1 1 0 Immunity protein 22 TipAS PF07739.13 CCM04946.1 - 0.17 12.4 1.8 12 6.5 0.3 2.9 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain RFC1 PF08519.12 CCM04947.1 - 1.3e-56 191.1 0.0 3.5e-55 186.5 0.0 2.5 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 CCM04947.1 - 1e-13 51.5 0.0 3.7e-13 49.7 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 CCM04947.1 - 3.1e-08 34.1 0.0 8.1e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CCM04947.1 - 0.00073 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 CCM04947.1 - 0.0033 17.1 0.2 0.0033 17.1 0.2 2.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CCM04947.1 - 0.0066 16.9 0.0 0.019 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 CCM04947.1 - 0.0078 16.3 0.0 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CCM04947.1 - 0.011 15.9 0.5 0.24 11.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 CCM04947.1 - 0.015 15.0 0.0 0.039 13.7 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CCM04947.1 - 0.025 14.9 0.1 0.11 12.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CCM04947.1 - 0.042 13.8 0.3 0.18 11.8 0.0 2.2 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_assoc_2 PF16193.5 CCM04947.1 - 0.045 14.1 0.0 0.17 12.3 0.0 2.0 1 0 0 1 1 1 0 AAA C-terminal domain AAA_24 PF13479.6 CCM04947.1 - 0.051 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CCM04947.1 - 0.059 13.3 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 NTPase DNA_pol3_delta PF06144.13 CCM04947.1 - 0.061 13.1 0.1 0.22 11.3 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase III, delta subunit FerA PF08165.11 CCM04947.1 - 0.064 13.2 0.6 0.48 10.4 0.1 2.5 2 0 0 2 2 2 0 FerA (NUC095) domain TnpW PF14202.6 CCM04947.1 - 0.092 12.6 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Transposon-encoded protein TnpW Sigma54_activat PF00158.26 CCM04947.1 - 0.17 11.6 0.0 0.37 10.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Asp PF00026.23 CCM04948.1 - 1.7e-74 251.1 0.2 2.1e-74 250.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM04948.1 - 4.7e-08 33.5 0.3 0.0025 18.1 0.0 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCM04948.1 - 0.00058 20.5 0.1 2.2 9.0 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 CCM04948.1 - 0.0061 16.3 0.2 0.029 14.1 0.2 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal SH3_9 PF14604.6 CCM04949.1 - 3.4e-08 33.2 0.0 5.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCM04949.1 - 0.0025 17.4 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain Tad PF13400.6 CCM04949.1 - 0.14 12.5 2.0 0.25 11.7 2.0 1.4 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like PgaD PF13994.6 CCM04950.1 - 0.037 14.1 0.7 0.077 13.1 0.7 1.5 1 0 0 1 1 1 0 PgaD-like protein DUF1634 PF07843.11 CCM04950.1 - 0.12 12.5 0.2 1.3 9.2 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1634) GMC_oxred_N PF00732.19 CCM04951.1 - 4.6e-63 213.3 0.0 7.7e-63 212.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM04951.1 - 3.2e-33 115.3 0.0 6.3e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCM04951.1 - 3.5e-06 26.3 0.1 5.4e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 CCM04951.1 - 0.00072 18.9 0.3 0.0072 15.6 0.1 2.2 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 CCM04951.1 - 0.0048 16.0 0.6 0.02 14.0 0.6 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM04951.1 - 0.069 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM04951.1 - 0.16 10.6 0.7 0.27 9.9 0.7 1.3 1 0 0 1 1 1 0 HI0933-like protein Borrelia_P83 PF05262.11 CCM04952.1 - 0.00012 20.7 0.8 0.00016 20.3 0.8 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein DivIC PF04977.15 CCM04952.1 - 0.13 12.0 3.5 0.15 11.8 1.7 1.9 1 1 1 2 2 2 0 Septum formation initiator Rnk_N PF14760.6 CCM04952.1 - 0.42 11.1 4.5 0.45 11.0 2.8 2.0 2 0 0 2 2 2 0 Rnk N-terminus AAA PF00004.29 CCM04953.1 - 3.1e-49 166.8 0.0 1.2e-41 142.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CCM04953.1 - 2.6e-09 36.8 0.0 9.1e-09 35.0 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CCM04953.1 - 1.6e-07 31.8 5.7 5.2e-05 23.7 0.2 4.0 2 2 1 3 3 3 2 AAA ATPase domain IstB_IS21 PF01695.17 CCM04953.1 - 3.5e-07 30.1 0.0 2.7e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 CCM04953.1 - 2.2e-05 24.6 0.0 5.4e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CCM04953.1 - 3.1e-05 24.2 0.4 0.18 12.0 0.0 3.7 2 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CCM04953.1 - 0.00012 22.2 1.3 0.029 14.5 0.0 3.5 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 CCM04953.1 - 0.00045 19.9 0.0 0.46 10.0 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 CCM04953.1 - 0.0011 19.0 0.1 0.028 14.4 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Torsin PF06309.11 CCM04953.1 - 0.011 15.8 0.0 2.2 8.4 0.0 2.4 2 0 0 2 2 2 0 Torsin TsaE PF02367.17 CCM04953.1 - 0.012 15.6 0.0 3.4 7.7 0.0 3.2 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CCM04953.1 - 0.025 15.0 0.0 0.23 11.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 CCM04953.1 - 0.041 14.4 0.0 0.32 11.5 0.0 2.5 3 0 0 3 3 2 0 ABC transporter AAA_3 PF07726.11 CCM04953.1 - 0.042 13.7 0.0 0.15 11.9 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCM04953.1 - 0.042 13.5 0.0 1.4 8.6 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_28 PF13521.6 CCM04953.1 - 0.048 13.9 0.0 0.22 11.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CCM04953.1 - 0.057 14.0 0.0 0.057 14.0 0.0 2.5 3 0 0 3 3 1 0 AAA domain Mg_chelatase PF01078.21 CCM04953.1 - 0.058 12.8 0.1 0.15 11.5 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CCM04953.1 - 0.062 12.8 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 CCM04953.1 - 0.062 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CCM04953.1 - 0.065 13.1 0.0 0.6 10.0 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 CCM04953.1 - 0.067 13.2 0.0 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 CCM04953.1 - 0.083 12.9 0.0 0.99 9.4 0.0 2.5 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit RuvB_N PF05496.12 CCM04953.1 - 0.089 12.5 0.0 0.28 10.9 0.0 1.9 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AFG1_ATPase PF03969.16 CCM04953.1 - 0.092 11.6 0.1 1.2 7.9 0.0 2.5 3 0 0 3 3 3 0 AFG1-like ATPase TIP49 PF06068.13 CCM04953.1 - 0.1 11.8 0.0 0.24 10.6 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain PhoH PF02562.16 CCM04953.1 - 0.12 11.8 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 CCM04953.1 - 0.15 11.1 0.0 0.61 9.1 0.0 2.0 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 CCM04953.1 - 0.15 12.2 0.0 7.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 CCM04953.1 - 0.82 9.4 0.0 0.82 9.4 0.0 2.7 3 1 0 3 3 2 0 AAA domain Glyco_hydro_85 PF03644.13 CCM04954.1 - 1.9e-81 273.8 0.0 2.6e-81 273.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Pex14_N PF04695.13 CCM04955.1 - 5.1 7.7 14.1 7.1 7.3 14.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RRM_1 PF00076.22 CCM04956.1 - 3.1e-25 87.8 0.3 7.4e-15 54.5 0.2 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM04956.1 - 8.8e-07 29.0 0.0 0.044 13.9 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif Suf PF05843.14 CCM04957.1 - 3.1e-72 244.1 0.0 2.3e-69 234.6 0.0 3.2 2 1 1 3 3 3 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CCM04957.1 - 0.00024 21.6 1.3 8.4 7.5 0.0 5.2 5 1 1 6 6 6 1 Tetratricopeptide repeat FTCD_C PF04961.12 CCM04957.1 - 0.0045 16.8 0.1 0.014 15.2 0.0 1.8 2 0 0 2 2 2 1 Formiminotransferase-cyclodeaminase NRDE-2 PF08424.10 CCM04957.1 - 0.023 13.8 13.6 0.15 11.1 3.7 4.9 3 1 0 3 3 3 0 NRDE-2, necessary for RNA interference TPR_6 PF13174.6 CCM04957.1 - 0.071 13.8 0.3 12 6.8 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 CCM04957.1 - 0.095 11.9 5.3 0.18 10.9 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Cytochrom_B562 PF07361.11 CCM04957.1 - 0.63 10.7 2.4 4.3 8.0 0.2 3.4 4 0 0 4 4 4 0 Cytochrome b562 Cupin_1 PF00190.22 CCM04958.1 - 1.7e-29 102.3 0.1 1.5e-18 66.9 0.0 3.2 2 1 1 3 3 3 3 Cupin Cupin_2 PF07883.11 CCM04958.1 - 1.6e-19 69.4 0.1 5.4e-13 48.5 0.0 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 CCM04958.1 - 3.4e-07 30.2 0.1 3e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_3 PF05899.12 CCM04958.1 - 2.4e-05 23.9 0.0 0.00049 19.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF861) DUF1971 PF09313.11 CCM04958.1 - 0.013 15.5 0.0 3.5 7.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1971) ARD PF03079.14 CCM04958.1 - 0.037 14.2 0.0 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 ARD/ARD' family Cupin_8 PF13621.6 CCM04958.1 - 0.071 12.8 0.0 0.12 12.0 0.0 1.5 1 1 0 1 1 1 0 Cupin-like domain 3-HAO PF06052.12 CCM04958.1 - 0.092 12.4 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Cupin_4 PF08007.12 CCM04958.1 - 0.12 11.8 0.0 4.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Cupin superfamily protein MannoseP_isomer PF01050.18 CCM04958.1 - 0.21 11.5 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase Cupin_1 PF00190.22 CCM04960.1 - 1.2e-40 138.6 0.0 1.5e-19 70.1 0.0 2.3 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCM04960.1 - 9.2e-29 99.0 0.9 7.3e-14 51.2 0.6 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCM04960.1 - 8.4e-09 35.0 0.2 0.0012 18.4 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 CCM04960.1 - 2.7e-05 24.1 0.0 0.00049 20.0 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase AraC_binding PF02311.19 CCM04960.1 - 4.6e-05 23.3 1.0 0.0025 17.7 0.0 2.3 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_4 PF08007.12 CCM04960.1 - 0.012 15.1 0.1 0.1 12.1 0.0 2.0 2 0 0 2 2 2 0 Cupin superfamily protein Pirin_C PF05726.13 CCM04960.1 - 0.11 12.9 0.0 19 5.7 0.0 2.4 2 0 0 2 2 2 0 Pirin C-terminal cupin domain Mucin PF01456.17 CCM04960.1 - 0.21 11.6 14.5 0.49 10.4 14.5 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2448 PF10476.9 CCM04960.1 - 0.81 9.5 2.0 0.68 9.8 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) SprA-related PF12118.8 CCM04960.1 - 2.4 7.2 7.7 35 3.4 6.1 2.2 2 0 0 2 2 2 0 SprA-related family SNO PF01174.19 CCM04961.1 - 2.4e-50 171.0 0.0 1.8e-48 164.9 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 CCM04961.1 - 7.6e-08 32.2 0.0 9.7e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 CCM04961.1 - 0.00013 21.7 0.0 0.00018 21.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 CCM04961.1 - 0.028 14.2 0.1 0.045 13.6 0.1 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Peptidase_S10 PF00450.22 CCM04962.1 - 6.6e-72 243.2 0.0 1.1e-71 242.4 0.0 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.22 CCM04963.1 - 2.6e-09 37.0 0.0 2.8e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase HATPase_c PF02518.26 CCM04966.1 - 9e-17 61.6 0.4 2.2e-16 60.3 0.2 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CCM04966.1 - 1.4e-14 53.9 0.7 4.6e-14 52.2 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CCM04966.1 - 5.1e-12 45.9 0.0 7.8e-11 42.1 0.0 2.4 1 1 0 1 1 1 1 Response regulator receiver domain GAF PF01590.26 CCM04966.1 - 3.9e-07 30.8 0.0 0.0031 18.1 0.0 2.7 2 0 0 2 2 2 2 GAF domain Cys_Met_Meta_PP PF01053.20 CCM04967.1 - 2e-31 108.9 0.0 3e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GHMP_kinases_N PF00288.26 CCM04967.1 - 7.6e-18 64.5 0.0 2.9e-17 62.6 0.0 2.1 1 1 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CCM04967.1 - 5.1e-06 26.8 1.6 3e-05 24.3 0.1 2.8 1 1 1 2 2 2 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 CCM04967.1 - 0.001 18.6 0.0 0.0028 17.2 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature Cys_Met_Meta_PP PF01053.20 CCM04968.1 - 4.8e-72 242.6 0.2 6.1e-72 242.3 0.2 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SelA PF03841.13 CCM04968.1 - 4.3e-05 22.7 0.0 0.042 12.8 0.0 2.1 2 0 0 2 2 2 2 L-seryl-tRNA selenium transferase Aminotran_1_2 PF00155.21 CCM04968.1 - 0.00019 20.7 0.0 0.00025 20.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 CCM04968.1 - 0.0016 17.1 0.0 0.016 13.8 0.0 1.9 2 0 0 2 2 2 1 Methionine gamma-lyase DegT_DnrJ_EryC1 PF01041.17 CCM04968.1 - 0.026 13.8 0.1 0.055 12.8 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CCM04968.1 - 0.031 13.6 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Wbp11 PF09429.10 CCM04969.1 - 0.0045 17.4 1.0 0.048 14.1 0.2 2.1 2 0 0 2 2 2 1 WW domain binding protein 11 adh_short PF00106.25 CCM04970.1 - 1e-25 90.3 0.1 3.7e-25 88.5 0.1 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM04970.1 - 1.1e-14 54.6 0.5 1.5e-12 47.6 0.4 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM04970.1 - 7.3e-06 26.0 0.6 1.6e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CCM04970.1 - 0.0014 18.2 0.0 0.14 11.6 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Pyr_redox_2 PF07992.14 CCM04970.1 - 0.0014 17.9 0.1 0.0021 17.4 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DFP PF04127.15 CCM04970.1 - 0.0038 17.1 0.2 0.084 12.7 0.2 2.1 1 1 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Sacchrp_dh_NADP PF03435.18 CCM04970.1 - 0.021 15.1 0.0 0.041 14.2 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain LYTB PF02401.18 CCM04970.1 - 0.1 11.8 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 LytB protein Polysacc_synt_2 PF02719.15 CCM04970.1 - 0.11 11.7 0.0 0.25 10.4 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CCM04970.1 - 0.11 12.4 0.4 0.35 10.8 0.3 2.0 2 1 0 2 2 2 0 NAD(P)H-binding CoA_binding_3 PF13727.6 CCM04970.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 CoA-binding domain Eno-Rase_NADH_b PF12242.8 CCM04970.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADH_zinc_N PF00107.26 CCM04970.1 - 0.17 11.8 0.1 0.3 11.0 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Cas_TM1802 PF09484.10 CCM04970.1 - 0.32 9.7 0.0 0.6 8.8 0.0 1.3 2 0 0 2 2 2 0 CRISPR-associated protein TM1802 (cas_TM1802) Abhydrolase_1 PF00561.20 CCM04971.1 - 1.1e-43 149.7 0.0 1.6e-43 149.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM04971.1 - 0.03 14.9 8.2 0.12 12.9 8.2 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family AATase PF07247.12 CCM04972.1 - 2e-25 89.3 0.0 5.6e-25 87.8 0.0 1.6 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 CCM04972.1 - 3.2e-09 36.0 0.0 1.8e-08 33.5 0.0 2.0 3 0 0 3 3 3 1 Condensation domain WES_acyltransf PF03007.16 CCM04972.1 - 0.086 12.6 0.0 0.18 11.6 0.0 1.5 1 1 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Terpene_synth_C PF03936.16 CCM04973.1 - 0.0018 17.7 0.1 0.0028 17.0 0.1 1.3 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain HMGL-like PF00682.19 CCM04974.1 - 3.4e-79 266.1 0.2 4.8e-79 265.6 0.2 1.2 1 0 0 1 1 1 1 HMGL-like Terpene_synth_C PF03936.16 CCM04975.1 - 1e-05 25.0 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain RNA_pol_Rpb5_C PF01191.19 CCM04976.1 - 2.2e-33 114.0 0.2 4.7e-33 112.9 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 CCM04976.1 - 2.7e-30 104.8 0.2 4.7e-30 104.0 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 CCM04976.1 - 0.001 19.1 0.0 0.049 13.7 0.0 2.3 2 1 0 2 2 2 1 Restriction endonuclease WD40 PF00400.32 CCM04977.1 - 3.9e-19 68.6 0.5 2e-05 25.3 0.0 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM04977.1 - 0.00012 22.3 0.0 0.36 11.1 0.0 3.7 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Acetyltransf_3 PF13302.7 CCM04978.1 - 8.7e-12 45.9 0.0 1.1e-11 45.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCM04978.1 - 0.001 19.3 0.0 0.0022 18.2 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family TRAP_alpha PF03896.16 CCM04979.1 - 3.4e-07 29.8 0.0 4.2e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF2290 PF10053.9 CCM04979.1 - 0.0055 16.2 0.0 0.0083 15.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2290) NDUFB10 PF10249.9 CCM04980.1 - 0.0035 17.9 0.9 0.0037 17.8 0.9 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 RAG2_PHD PF13341.6 CCM04980.1 - 0.076 13.1 0.0 0.088 12.9 0.0 1.1 1 0 0 1 1 1 0 RAG2 PHD domain Asp PF00026.23 CCM04981.1 - 8.1e-64 216.0 1.2 9.8e-64 215.7 1.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM04981.1 - 3.7e-09 37.1 1.4 3.2e-07 30.8 1.4 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Pkinase PF00069.25 CCM04982.1 - 6.8e-49 166.6 0.0 1.3e-48 165.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM04982.1 - 8.3e-18 64.6 0.0 1.9e-17 63.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCM04982.1 - 0.078 12.3 0.5 0.47 9.8 0.1 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM04982.1 - 0.12 11.9 0.1 0.33 10.5 0.1 1.6 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 CCM04982.1 - 0.24 11.3 1.2 2.1 8.2 0.2 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family MOZ_SAS PF01853.18 CCM04983.1 - 1.1e-72 243.5 0.0 1.5e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family PHD PF00628.29 CCM04983.1 - 2.8e-19 68.8 20.7 4.4e-10 39.3 6.0 3.3 2 1 1 3 3 3 2 PHD-finger zf-MYST PF17772.1 CCM04983.1 - 1.5e-17 62.9 1.7 2.2e-17 62.4 0.3 2.1 2 0 0 2 2 2 1 MYST family zinc finger domain PHD_2 PF13831.6 CCM04983.1 - 0.0061 16.1 13.1 0.026 14.1 1.9 3.4 3 0 0 3 3 3 2 PHD-finger PHD_4 PF16866.5 CCM04983.1 - 0.55 10.4 22.0 0.32 11.1 8.2 2.6 1 1 1 2 2 2 0 PHD-finger Prok-RING_1 PF14446.6 CCM04983.1 - 2.3 8.2 12.3 4.1 7.4 0.6 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-HC5HC2H PF13771.6 CCM04983.1 - 2.5 8.4 12.6 12 6.2 5.1 2.5 1 1 1 2 2 2 0 PHD-like zinc-binding domain Zf_RING PF16744.5 CCM04983.1 - 4.3 7.5 13.3 1.7 8.8 5.8 2.7 1 1 1 2 2 2 0 KIAA1045 RING finger zf-HC5HC2H_2 PF13832.6 CCM04983.1 - 5.3 7.3 9.9 7.8 6.7 3.1 2.4 1 1 1 2 2 2 0 PHD-zinc-finger like domain DUF1295 PF06966.12 CCM04984.1 - 2.3e-42 145.1 0.1 3e-42 144.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 CCM04984.1 - 8.9e-06 26.0 0.1 2e-05 24.9 0.1 1.6 1 1 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM04984.1 - 0.00049 20.5 0.0 0.0012 19.2 0.0 1.7 1 0 0 1 1 1 1 Phospholipid methyltransferase Steroid_dh PF02544.16 CCM04984.1 - 0.0052 16.8 0.1 0.0093 16.0 0.1 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Thioredoxin PF00085.20 CCM04985.1 - 0.00061 19.8 0.1 0.0011 18.9 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 CCM04985.1 - 0.015 15.2 0.1 0.027 14.4 0.1 1.4 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 CCM04985.1 - 0.025 14.3 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Redoxin DUF3437 PF11919.8 CCM04986.1 - 0.18 11.7 0.2 0.43 10.5 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Amidohydro_1 PF01979.20 CCM04988.1 - 7.2e-67 226.1 0.3 1.1e-66 225.6 0.3 1.2 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 CCM04988.1 - 7.5e-57 190.9 0.7 1.5e-56 189.9 0.7 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 CCM04988.1 - 9.6e-42 141.0 0.0 2.1e-41 139.9 0.0 1.6 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 CCM04988.1 - 7.1e-39 132.1 0.1 2e-38 130.7 0.1 1.8 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 CCM04988.1 - 0.00028 20.5 0.1 0.003 17.1 0.0 2.4 2 1 0 2 2 2 1 Amidohydrolase family RNA_pol_Rpc82 PF05645.13 CCM04989.1 - 0.018 14.8 0.3 0.028 14.2 0.3 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 zf-NF-X1 PF01422.17 CCM04989.1 - 0.029 14.4 2.0 0.047 13.8 2.0 1.3 1 0 0 1 1 1 0 NF-X1 type zinc finger Acyl-CoA_dh_1 PF00441.24 CCM04990.1 - 2.1e-33 115.6 1.4 3e-33 115.2 1.4 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 CCM04990.1 - 1.3e-15 57.2 0.0 3.9e-15 55.7 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 CCM04990.1 - 5.5e-13 48.9 1.1 1.2e-12 47.8 1.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CCM04990.1 - 9.2e-11 42.4 0.1 3.2e-10 40.7 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CCM04990.1 - 5.4e-06 26.7 1.0 9.8e-06 25.9 1.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain RRM_1 PF00076.22 CCM04991.1 - 0.00042 20.1 0.0 0.0007 19.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPT2 PF08243.11 CCM04992.1 - 4.8e-19 68.9 10.5 4.8e-19 68.9 10.5 4.3 4 1 1 5 5 5 1 SPT2 chromatin protein MFS_1 PF07690.16 CCM04993.1 - 6.7e-35 120.7 55.7 8e-29 100.7 30.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Metallophos PF00149.28 CCM04993.1 - 1.2e-12 48.8 1.4 1.2e-12 48.8 1.4 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCM04993.1 - 2.9e-05 24.3 0.0 0.00097 19.4 0.0 2.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Sugar_tr PF00083.24 CCM04993.1 - 0.00044 19.2 22.6 0.0017 17.3 22.6 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CCM04993.1 - 0.0018 16.8 0.6 0.0018 16.8 0.6 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Hva1_TUDOR PF11160.8 CCM04994.1 - 1.9e-08 34.4 0.2 1.1e-06 28.7 0.2 2.0 1 1 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain Invasin_D3 PF09134.10 CCM04994.1 - 0.002 18.4 0.5 0.0023 18.2 0.5 1.1 1 0 0 1 1 1 1 Invasin, domain 3 Tudor_RapA PF18337.1 CCM04994.1 - 0.066 13.4 0.5 0.19 11.9 0.2 1.8 2 0 0 2 2 2 0 RapA N-terminal Tudor like domain TOM13 PF08219.11 CCM04995.1 - 2.3e-12 46.7 0.5 8.3e-12 44.9 0.5 1.9 1 0 0 1 1 1 1 Outer membrane protein TOM13 MAP7 PF05672.11 CCM04995.1 - 0.0027 17.4 8.6 0.0046 16.7 8.6 1.4 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family DUF3106 PF11304.8 CCM04995.1 - 0.018 15.5 6.9 0.049 14.1 6.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) Rap1_C PF11626.8 CCM04995.1 - 0.064 13.3 3.2 0.055 13.6 1.7 1.7 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain GrpE PF01025.19 CCM04995.1 - 0.12 12.0 0.7 0.18 11.5 0.7 1.2 1 0 0 1 1 1 0 GrpE Presenilin PF01080.17 CCM04995.1 - 0.54 9.0 1.0 2.2 7.0 1.0 1.8 1 1 0 1 1 1 0 Presenilin SPA PF08616.10 CCM04996.1 - 1.8e-07 31.1 0.0 3.2e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 CCM04996.1 - 0.051 12.3 0.0 0.073 11.8 0.0 1.2 1 0 0 1 1 1 0 Transport protein Avl9 Tcp11 PF05794.13 CCM05001.1 - 4.6e-16 59.0 0.3 9.7e-15 54.6 0.0 2.5 2 1 0 2 2 2 1 T-complex protein 11 p450 PF00067.22 CCM05003.1 - 6.1e-64 216.5 0.0 9e-64 215.9 0.0 1.2 1 1 0 1 1 1 1 Cytochrome P450 Mg_trans_NIPA PF05653.14 CCM05004.1 - 4.5e-17 62.1 16.3 4.4e-09 35.9 3.6 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CCM05004.1 - 2e-07 31.3 27.1 1e-05 25.7 5.1 3.6 3 1 0 3 3 3 2 EamA-like transporter family DUF3169 PF11368.8 CCM05004.1 - 1.1 8.7 10.4 2.3 7.7 0.8 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) TssO PF17561.2 CCM05004.1 - 1.4 9.0 0.0 1.4 9.0 0.0 2.5 3 0 0 3 3 3 0 Type VI secretion system, TssO DUF262 PF03235.14 CCM05005.1 - 2.5e-08 34.4 0.1 7.9e-08 32.7 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function DUF262 Dcc1 PF09724.9 CCM05006.1 - 1.7e-86 290.6 0.0 2e-86 290.4 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Cation_efflux PF01545.21 CCM05007.1 - 3.2e-47 160.8 1.5 1.1e-46 159.2 1.5 1.7 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CCM05007.1 - 0.0002 21.4 0.1 0.0004 20.4 0.1 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Fe-ADH PF00465.19 CCM05008.1 - 2.8e-67 227.1 0.0 3.2e-67 226.9 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCM05008.1 - 5.8e-16 58.9 0.1 1.1e-15 58.1 0.1 1.4 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fungal_trans PF04082.18 CCM05010.1 - 1.4e-21 76.8 0.1 5.2e-21 74.9 0.0 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain TMEM192 PF14802.6 CCM05010.1 - 0.15 11.1 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 TMEM192 family Flavin_Reduct PF01613.18 CCM05012.1 - 5e-21 75.4 0.6 7.4e-21 74.8 0.6 1.2 1 0 0 1 1 1 1 Flavin reductase like domain DUF447 PF04289.12 CCM05012.1 - 0.053 13.3 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF447) Sec7 PF01369.20 CCM05013.1 - 4.1e-32 111.3 0.0 5.5e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain FixG_C PF11614.8 CCM05013.1 - 0.015 15.5 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase IQ_SEC7_PH PF16453.5 CCM05013.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 PH domain CHCH PF06747.13 CCM05015.1 - 3.4e-07 30.2 3.4 6.7e-07 29.3 3.4 1.5 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 CCM05015.1 - 0.14 12.6 1.3 0.23 11.9 1.3 1.4 1 0 0 1 1 1 0 GCK domain Lactamase_B PF00753.27 CCM05016.1 - 4.1e-07 30.2 0.8 7.3e-07 29.4 0.8 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCM05016.1 - 0.00029 20.4 0.3 0.00066 19.3 0.3 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain E1-E2_ATPase PF00122.20 CCM05018.1 - 1.8e-30 105.8 0.0 4.2e-30 104.6 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 CCM05018.1 - 2.8e-25 88.8 0.0 6.6e-25 87.6 0.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 CCM05018.1 - 2.5e-18 67.1 0.0 4.9e-09 36.8 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase V-SNARE_C PF12352.8 CCM05018.1 - 2e-16 60.0 0.1 4.5e-16 58.9 0.1 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Cation_ATPase_C PF00689.21 CCM05018.1 - 1.9e-06 27.7 5.7 4.3e-06 26.6 5.7 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CCM05018.1 - 3.9e-05 23.7 0.2 0.00053 20.0 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Sec20 PF03908.13 CCM05018.1 - 0.0038 17.1 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 Sec20 Cation_ATPase_N PF00690.26 CCM05018.1 - 0.013 15.1 0.0 0.034 13.8 0.0 1.7 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Methyltransf_16 PF10294.9 CCM05019.1 - 8.6e-15 54.9 0.0 1.1e-13 51.3 0.0 2.5 1 1 0 1 1 1 1 Lysine methyltransferase Nop25 PF09805.9 CCM05020.1 - 1.5e-22 80.5 20.3 1.5e-22 80.5 20.3 2.4 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) OPT PF03169.15 CCM05021.1 - 1.7e-198 661.2 60.2 1.9e-198 661.0 60.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Lactamase_B PF00753.27 CCM05022.1 - 4.1e-11 43.3 1.9 6.3e-11 42.6 1.9 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCM05022.1 - 0.013 15.1 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Pyr_redox_2 PF07992.14 CCM05023.1 - 8.7e-67 225.4 0.5 1.3e-66 224.8 0.5 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CCM05023.1 - 1.5e-30 105.7 0.0 2.9e-30 104.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CCM05023.1 - 6.1e-20 71.6 4.5 6.7e-19 68.2 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM05023.1 - 9.5e-16 57.9 0.8 4.3e-15 55.8 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM05023.1 - 3.3e-08 32.7 1.9 0.0071 15.1 0.7 3.1 3 0 0 3 3 3 2 HI0933-like protein FAD_oxidored PF12831.7 CCM05023.1 - 5.5e-07 29.3 0.3 1.1e-06 28.3 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CCM05023.1 - 6.9e-07 28.7 0.0 1.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCM05023.1 - 0.003 17.8 1.0 0.0097 16.1 1.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CCM05023.1 - 0.0061 15.7 2.1 0.0061 15.7 2.1 2.3 2 1 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 CCM05023.1 - 0.0092 15.2 0.5 0.024 13.9 0.1 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 CCM05023.1 - 0.011 14.8 4.5 0.23 10.5 2.4 2.7 3 0 0 3 3 3 0 FAD binding domain NAD_binding_9 PF13454.6 CCM05023.1 - 0.016 15.2 0.1 1.5 8.8 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 CCM05023.1 - 0.074 12.3 0.8 9 5.5 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CCM05023.1 - 0.086 12.7 0.1 0.086 12.7 0.1 2.1 3 0 0 3 3 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CCM05023.1 - 3.9 6.4 7.3 8.2 5.4 0.2 2.8 3 1 0 3 3 3 0 Lycopene cyclase protein zf-ACC PF17848.1 CCM05025.1 - 0.058 13.5 0.4 0.083 13.0 0.4 1.2 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain APH PF01636.23 CCM05026.1 - 1.3e-07 31.8 1.5 1.9e-06 28.0 1.3 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM05026.1 - 0.012 15.2 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Dynamin_M PF01031.20 CCM05028.1 - 7.3e-100 333.9 0.0 1.4e-99 332.9 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CCM05028.1 - 5e-55 186.1 0.0 9.8e-55 185.2 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CCM05028.1 - 2e-30 104.8 3.3 4.6e-30 103.6 3.3 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCM05028.1 - 1.4e-05 25.1 0.3 0.0002 21.4 0.3 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 CCM05028.1 - 0.058 13.1 0.4 12 5.5 0.1 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.6 CCM05028.1 - 0.11 12.9 0.0 0.33 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Glyco_hydro_88 PF07470.13 CCM05029.1 - 1.1e-10 41.2 1.1 1.3e-10 40.9 1.1 1.3 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 NTF2 PF02136.20 CCM05030.1 - 5.2e-33 114.2 0.1 5.8e-33 114.0 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 CCM05030.1 - 0.0086 16.0 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 Gag_spuma PF03276.14 CCM05031.1 - 0.063 11.7 0.6 0.078 11.4 0.6 1.1 1 0 0 1 1 1 0 Spumavirus gag protein TBP PF00352.21 CCM05033.1 - 3.7e-66 219.1 0.2 3.2e-32 110.3 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CCM05033.1 - 6.2e-05 23.0 0.4 0.41 10.8 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 CCM05033.1 - 0.12 12.2 0.0 0.34 10.8 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) TFIIA PF03153.13 CCM05033.1 - 3.3 7.6 14.0 4.2 7.3 14.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Biotin_lipoyl PF00364.22 CCM05034.1 - 2.8e-20 71.9 0.1 5.1e-20 71.1 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CCM05034.1 - 6.6e-07 29.6 0.1 1.8e-06 28.2 0.1 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CCM05034.1 - 0.027 14.3 0.1 0.22 11.4 0.0 2.4 2 0 0 2 2 2 0 Biotin-lipoyl like Sterol-sensing PF12349.8 CCM05035.1 - 1.7e-37 128.6 9.1 1.7e-37 128.6 9.1 1.9 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CCM05035.1 - 8.4e-13 47.3 7.1 1.3e-12 46.7 7.1 1.1 1 0 0 1 1 1 1 Patched family ABM PF03992.16 CCM05036.1 - 0.00011 22.2 0.0 0.29 11.3 0.0 2.2 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase Arginase PF00491.21 CCM05037.1 - 5.8e-84 281.9 0.1 6.8e-84 281.7 0.1 1.0 1 0 0 1 1 1 1 Arginase family DUF3535 PF12054.8 CCM05038.1 - 7.2e-103 345.1 0.3 7.2e-103 345.1 0.3 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 CCM05038.1 - 2.3e-67 227.2 0.0 4.6e-67 226.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM05038.1 - 5.3e-17 62.2 0.0 1.3e-16 60.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 CCM05038.1 - 7.1e-13 47.6 15.1 0.37 11.2 0.2 9.8 10 0 0 10 10 8 5 HEAT repeat HEAT_EZ PF13513.6 CCM05038.1 - 2.1e-07 31.3 11.1 1.6 9.3 0.1 9.0 8 2 1 9 9 8 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CCM05038.1 - 0.00059 20.4 0.0 1.7 9.3 0.0 2.9 2 0 0 2 2 2 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 CCM05038.1 - 0.0019 17.8 0.0 0.012 15.2 0.0 2.3 2 0 0 2 2 2 1 CLASP N terminal DUF3385 PF11865.8 CCM05038.1 - 0.019 14.9 0.3 0.053 13.4 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) HEAT_2 PF13646.6 CCM05038.1 - 0.034 14.5 9.1 13 6.3 0.0 6.9 6 2 1 7 7 7 0 HEAT repeats TAF6_C PF07571.13 CCM05038.1 - 0.12 12.8 0.3 5.8 7.3 0.0 3.9 6 0 0 6 6 5 0 TAF6 C-terminal HEAT repeat domain ERCC3_RAD25_C PF16203.5 CCM05038.1 - 0.15 11.2 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Cupin_8 PF13621.6 CCM05039.1 - 2.9e-35 122.2 0.1 4.2e-35 121.7 0.1 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CCM05039.1 - 1.8e-06 27.7 0.0 4.9e-06 26.2 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_2 PF07883.11 CCM05039.1 - 0.0013 18.4 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 Cupin domain JmjC PF02373.22 CCM05039.1 - 0.0016 18.8 0.0 0.011 16.1 0.0 2.2 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_3 PF05899.12 CCM05039.1 - 0.029 14.1 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCM05039.1 - 0.062 13.2 0.2 0.23 11.3 0.0 2.0 3 0 0 3 3 3 0 AraC-like ligand binding domain RabGAP-TBC PF00566.18 CCM05040.1 - 3.3e-27 95.5 0.2 5.7e-26 91.5 0.2 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain FAD_binding_2 PF00890.24 CCM05041.1 - 1.5e-125 419.6 3.2 1.9e-125 419.3 3.2 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CCM05041.1 - 1.2e-44 151.4 0.3 1.7e-44 150.9 0.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 CCM05041.1 - 9.9e-06 24.9 1.9 0.0097 15.0 2.2 2.7 3 0 0 3 3 3 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 CCM05041.1 - 1.1e-05 24.8 1.6 0.0018 17.6 0.6 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM05041.1 - 3.3e-05 23.3 0.2 0.033 13.4 0.1 2.6 3 0 0 3 3 3 2 Thi4 family FAD_binding_3 PF01494.19 CCM05041.1 - 0.0028 17.0 0.1 0.0049 16.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CCM05041.1 - 0.037 13.1 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 CCM05041.1 - 0.049 13.2 1.4 0.15 11.6 1.4 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CCM05041.1 - 0.16 10.6 2.5 0.49 9.0 0.8 2.5 3 1 1 4 4 4 0 HI0933-like protein TAL_FSA PF00923.19 CCM05041.1 - 0.19 11.0 0.1 0.32 10.3 0.1 1.2 1 0 0 1 1 1 0 Transaldolase/Fructose-6-phosphate aldolase Pyr_redox_3 PF13738.6 CCM05041.1 - 3.2 6.9 4.2 2.8 7.1 1.3 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase G-patch PF01585.23 CCM05042.1 - 5.5e-07 29.4 4.1 1e-06 28.5 3.5 1.9 2 0 0 2 2 2 1 G-patch domain p450 PF00067.22 CCM05043.1 - 8.2e-68 229.2 0.0 9.6e-68 229.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cullin_binding PF03556.15 CCM05044.1 - 2.1e-27 96.0 1.4 3.2e-27 95.4 1.4 1.3 1 0 0 1 1 1 1 Cullin binding DUF2563 PF10817.8 CCM05044.1 - 0.11 13.1 0.2 0.22 12.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2563) FeS_assembly_P PF01883.19 CCM05046.1 - 1.2e-06 28.6 0.0 2.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein UCH_1 PF13423.6 CCM05048.1 - 4.2e-90 302.6 0.1 5.6e-90 302.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 CCM05048.1 - 1.9e-20 74.1 0.0 3.5e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 CCM05048.1 - 3.4e-06 26.7 0.0 8.1e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 CCM05048.1 - 0.02 15.8 0.5 2.4 9.2 0.0 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat Sas10_Utp3 PF04000.15 CCM05049.1 - 6.1e-12 46.0 0.0 1.1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Sas10/Utp3/C1D family HisKA_3 PF07730.13 CCM05049.1 - 0.02 15.4 0.6 0.071 13.6 0.1 2.3 2 0 0 2 2 2 0 Histidine kinase Abhydrolase_1 PF00561.20 CCM05050.1 - 6.7e-21 75.1 0.0 1.2e-20 74.3 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCM05050.1 - 2.8e-09 36.6 0.0 4.6e-06 26.1 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CCM05050.1 - 1e-07 32.8 0.0 1.4e-07 32.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CCM05050.1 - 0.0019 17.8 0.0 0.0036 16.9 0.0 1.4 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Cupredoxin_1 PF13473.6 CCM05051.1 - 0.003 17.6 0.2 0.53 10.4 0.0 2.9 3 0 0 3 3 3 1 Cupredoxin-like domain Copper-bind PF00127.20 CCM05051.1 - 0.0032 17.9 1.9 2.9 8.4 0.1 2.9 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family SAP130_C PF16014.5 CCM05051.1 - 0.15 11.1 7.3 0.22 10.6 7.3 1.3 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Cu_bind_like PF02298.17 CCM05051.1 - 0.34 11.0 4.2 21 5.2 0.3 3.6 2 2 0 2 2 2 0 Plastocyanin-like domain SWI-SNF_Ssr4 PF08549.10 CCM05051.1 - 1.1 7.8 5.6 1.8 7.1 5.6 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) dsDNA_bind PF01984.20 CCM05052.1 - 1.5e-29 102.5 10.1 1.8e-29 102.3 10.1 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain PCI PF01399.27 CCM05052.1 - 0.017 15.6 0.1 0.024 15.1 0.1 1.3 1 0 0 1 1 1 0 PCI domain zf-RING_4 PF14570.6 CCM05053.1 - 1.4e-22 79.2 11.8 2.4e-22 78.5 11.8 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 CCM05053.1 - 1.3e-06 28.1 8.6 2.5e-06 27.2 8.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCM05053.1 - 0.00013 21.8 8.6 0.00098 18.9 4.6 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 RRM_1 PF00076.22 CCM05053.1 - 0.00014 21.6 0.0 0.00044 20.0 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 CCM05053.1 - 0.0033 17.7 11.8 0.0062 16.9 11.8 1.5 1 0 0 1 1 1 1 Ring finger domain Baculo_IE-1 PF05290.11 CCM05053.1 - 0.055 13.4 3.7 0.1 12.5 3.7 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-UDP PF14569.6 CCM05053.1 - 0.12 12.6 2.8 0.25 11.5 2.8 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4 PF00097.25 CCM05053.1 - 0.14 12.1 11.8 0.23 11.3 11.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 CCM05053.1 - 0.17 11.8 1.0 13 5.7 0.1 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_2 PF13923.6 CCM05053.1 - 0.23 11.3 11.7 0.44 10.4 11.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM05053.1 - 0.26 11.4 7.7 0.65 10.1 6.6 2.1 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCM05056.1 - 1.1e-07 31.6 14.5 2.9e-07 30.2 10.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM05056.1 - 1.3e-07 31.4 13.2 1.3e-07 31.4 13.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM05056.1 - 1.3e-07 31.3 11.4 1.3e-07 31.3 11.4 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM05056.1 - 2.5e-07 30.6 16.5 1.2e-06 28.3 12.0 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCM05056.1 - 1.1e-06 28.5 8.5 1.1e-06 28.5 8.5 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CCM05056.1 - 2.7e-06 27.4 13.3 2.7e-06 27.4 13.3 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CCM05056.1 - 3.9e-06 27.1 17.9 5e-06 26.7 11.5 2.4 2 0 0 2 2 2 1 Ring finger domain U-box PF04564.15 CCM05056.1 - 4.1e-05 23.7 0.0 9.3e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-RING_6 PF14835.6 CCM05056.1 - 0.0002 21.2 4.0 0.00046 20.0 4.0 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 CCM05056.1 - 0.0016 18.5 7.6 0.0037 17.4 7.6 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 CCM05056.1 - 0.0023 17.7 15.3 0.082 12.8 10.5 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 PRP21_like_P PF12230.8 CCM05056.1 - 0.014 15.3 0.6 0.11 12.4 0.1 2.3 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein hDGE_amylase PF14701.6 CCM05056.1 - 0.052 12.6 0.0 0.086 11.9 0.0 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain zf-WRNIP1_ubi PF18279.1 CCM05056.1 - 0.064 13.9 3.3 0.2 12.4 0.6 2.8 3 0 0 3 3 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_4 PF14570.6 CCM05056.1 - 0.099 12.5 13.8 0.098 12.5 7.3 3.0 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CCM05056.1 - 0.19 12.0 15.6 0.056 13.7 9.5 2.9 2 1 0 2 2 2 0 RING-H2 zinc finger domain Tmemb_55A PF09788.9 CCM05056.1 - 0.45 9.5 8.2 0.039 13.0 3.1 1.7 2 0 0 2 2 2 0 Transmembrane protein 55A SPT6_acidic PF14632.6 CCM05056.1 - 2.4 8.8 8.5 0.52 10.9 0.3 3.0 3 0 0 3 3 3 0 Acidic N-terminal SPT6 zf-LITAF-like PF10601.9 CCM05056.1 - 5.1 7.4 11.0 13 6.2 5.9 2.4 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain NIF PF03031.18 CCM05057.1 - 1.9e-52 177.2 0.0 2.7e-52 176.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 CCM05057.1 - 0.079 13.4 0.1 0.43 11.0 0.0 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase KTI12 PF08433.10 CCM05059.1 - 1.1e-20 74.2 0.0 1.2e-20 74.1 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 O-FucT PF10250.9 CCM05060.1 - 3.3e-09 36.9 0.0 4.1e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase BTB PF00651.31 CCM05061.1 - 2.9e-11 43.6 0.0 6.2e-06 26.4 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain RhoGAP PF00620.27 CCM05062.1 - 3.9e-41 140.4 0.1 2.3e-40 137.9 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 CCM05062.1 - 2.6e-16 59.6 16.9 7.8e-08 32.4 1.3 2.4 2 0 0 2 2 2 2 LIM domain DUF3915 PF13054.6 CCM05062.1 - 0.29 11.1 4.9 0.88 9.6 4.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) LapD_MoxY_N PF16448.5 CCM05062.1 - 0.34 10.8 7.0 0.84 9.5 1.4 3.3 4 0 0 4 4 4 0 LapD/MoxY periplasmic domain YabA PF06156.13 CCM05062.1 - 3.4 8.4 10.7 0.43 11.2 1.7 3.1 2 1 2 4 4 4 0 Initiation control protein YabA COesterase PF00135.28 CCM05063.1 - 3.2e-83 280.3 0.0 4.6e-83 279.8 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CCM05063.1 - 0.052 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCM05063.1 - 0.054 13.4 0.0 0.16 11.8 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold adh_short PF00106.25 CCM05064.1 - 2.2e-32 112.1 0.0 2.9e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05064.1 - 1.7e-24 86.7 0.0 2e-24 86.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCM05064.1 - 1e-05 25.5 0.0 1.4e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCM05064.1 - 0.00017 21.6 0.0 0.00032 20.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM05064.1 - 0.022 14.2 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCM05064.1 - 0.047 12.9 0.0 1 8.5 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein adh_short PF00106.25 CCM05065.1 - 1.2e-33 116.2 0.0 1.6e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05065.1 - 1.6e-23 83.5 0.1 2e-23 83.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCM05065.1 - 1.3e-06 28.4 0.2 2e-06 27.8 0.2 1.4 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCM05065.1 - 1.6e-05 24.9 0.0 4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCM05065.1 - 0.004 16.6 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCM05065.1 - 0.017 14.6 0.0 0.024 14.1 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Amidase PF01425.21 CCM05066.1 - 4.6e-103 345.6 0.0 7.2e-103 345.0 0.0 1.3 1 1 0 1 1 1 1 Amidase DUF3439 PF11921.8 CCM05066.1 - 0.055 13.4 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) NIF PF03031.18 CCM05067.1 - 1.5e-55 187.2 0.2 2.3e-55 186.7 0.2 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 CCM05067.1 - 0.018 15.5 0.1 0.094 13.1 0.0 1.9 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase PTPLA PF04387.14 CCM05068.1 - 9.8e-57 191.3 9.5 1.5e-56 190.7 9.5 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA bZIP_1 PF00170.21 CCM05068.1 - 2.2e-05 24.5 8.3 2.2e-05 24.5 8.3 2.2 2 1 0 2 2 2 1 bZIP transcription factor DUF4439 PF14530.6 CCM05068.1 - 0.35 11.6 4.7 0.63 10.7 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4439) Asp PF00026.23 CCM05069.1 - 4.5e-53 180.7 0.3 6e-53 180.3 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM05069.1 - 4.7e-12 46.5 5.4 3.5e-05 24.1 0.7 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal adh_short PF00106.25 CCM05070.1 - 1.7e-26 92.9 0.0 2.3e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05070.1 - 3.5e-22 79.1 0.0 4.2e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05070.1 - 0.00071 19.5 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM05070.1 - 0.0042 16.6 0.0 0.007 15.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PPR_3 PF13812.6 CCM05072.1 - 5.3e-33 112.9 0.0 1.7e-08 34.4 0.0 5.1 5 0 0 5 5 5 4 Pentatricopeptide repeat domain PPR_2 PF13041.6 CCM05072.1 - 1.2e-32 111.8 0.1 6.5e-06 26.2 0.0 8.5 4 2 5 9 9 9 7 PPR repeat family PPR_long PF17177.4 CCM05072.1 - 5.3e-20 71.7 0.6 8.6e-07 28.5 0.1 4.1 1 1 3 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 CCM05072.1 - 9.7e-11 41.2 0.0 0.36 10.6 0.0 5.9 5 0 0 5 5 5 3 PPR repeat PPR PF01535.20 CCM05072.1 - 5.1e-10 38.9 2.0 6.3 7.3 0.0 8.4 9 0 0 9 9 9 2 PPR repeat GMP_synt_C PF00958.22 CCM05072.1 - 0.1 12.6 0.1 38 4.4 0.0 3.4 3 0 0 3 3 3 0 GMP synthase C terminal domain polyprenyl_synt PF00348.17 CCM05072.1 - 0.12 11.4 0.1 0.23 10.5 0.1 1.4 1 0 0 1 1 1 0 Polyprenyl synthetase TPR_14 PF13428.6 CCM05072.1 - 1.2 10.1 10.5 14 6.9 0.0 5.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 CCM05072.1 - 1.2 9.7 4.9 30 5.2 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat Rad21_Rec8_N PF04825.13 CCM05073.1 - 5.5e-25 87.7 0.2 1.3e-24 86.5 0.2 1.6 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 CCM05073.1 - 7.8e-10 37.9 0.0 1.6e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SHIPPO-rpt PF07004.12 CCM05073.1 - 0.0035 18.2 0.2 0.011 16.7 0.2 1.9 1 0 0 1 1 1 1 Sperm-tail PG-rich repeat TFA2_Winged_2 PF18121.1 CCM05073.1 - 0.045 13.4 0.7 0.2 11.4 0.0 2.3 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 DUF4201 PF13870.6 CCM05073.1 - 0.39 10.4 27.4 0.45 10.2 13.2 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 CCM05073.1 - 1.2 8.4 14.1 2.2 7.6 14.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 CCM05073.1 - 7.9 5.8 24.9 2.7 7.4 20.7 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 GIT_CC PF16559.5 CCM05073.1 - 9.3 6.2 14.3 0.088 12.7 4.3 2.9 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor ATG16 PF08614.11 CCM05073.1 - 9.9 6.3 30.9 46 4.1 30.9 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) PALP PF00291.25 CCM05074.1 - 4.7e-70 236.3 0.1 5.4e-70 236.1 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Arf PF00025.21 CCM05075.1 - 8.8e-77 256.5 0.0 1.2e-76 256.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCM05075.1 - 8.1e-15 55.1 0.1 1.3e-14 54.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CCM05075.1 - 1.3e-12 47.6 0.0 1.6e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CCM05075.1 - 2.3e-11 43.5 1.1 4.9e-07 29.2 0.1 2.5 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CCM05075.1 - 2.8e-11 43.2 0.0 4.8e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CCM05075.1 - 5.1e-09 35.8 0.0 8.9e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM05075.1 - 0.00044 20.3 0.0 0.0008 19.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CCM05075.1 - 0.041 13.2 0.1 0.067 12.5 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase LRR_4 PF12799.7 CCM05076.1 - 5.3e-12 45.8 17.9 6.7e-06 26.4 1.1 5.7 2 2 5 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCM05076.1 - 2.9e-10 39.8 15.2 1.4e-07 31.1 6.0 4.5 5 1 0 5 5 5 2 Leucine rich repeat LRR_9 PF14580.6 CCM05076.1 - 0.0019 17.7 2.2 0.021 14.3 0.4 2.7 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 CCM05076.1 - 0.18 12.4 14.7 9.5 7.2 0.2 6.7 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.6 CCM05076.1 - 0.3 11.3 15.1 2.3 8.5 1.0 5.3 6 0 0 6 6 6 0 Leucine Rich repeat ubiquitin PF00240.23 CCM05077.1 - 2.4e-22 78.5 1.7 3.6e-22 77.9 1.7 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CCM05077.1 - 2.6e-15 56.0 0.4 4e-15 55.4 0.4 1.3 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 CCM05077.1 - 4.6e-08 32.8 2.5 7e-08 32.2 2.5 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 CCM05077.1 - 2.3e-05 24.4 0.1 5.4e-05 23.3 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CCM05077.1 - 0.0011 19.5 0.0 0.002 18.6 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 CCM05077.1 - 0.01 15.9 0.8 0.05 13.7 0.5 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain Ubiquitin_5 PF18037.1 CCM05077.1 - 0.021 15.2 0.6 0.035 14.5 0.6 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_2 PF14560.6 CCM05077.1 - 0.024 15.1 0.4 0.039 14.4 0.4 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain NAP PF00956.18 CCM05077.1 - 0.044 12.9 0.1 0.087 12.0 0.1 1.3 1 1 0 1 1 1 0 Nucleosome assembly protein (NAP) UBA_3 PF09288.10 CCM05077.1 - 0.059 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain DUF1421 PF07223.11 CCM05077.1 - 0.15 11.9 0.1 0.33 10.8 0.1 1.5 1 0 0 1 1 1 0 UBA-like domain (DUF1421) FAP PF07174.11 CCM05077.1 - 4.9 6.5 25.9 7.7 5.9 25.9 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) p450 PF00067.22 CCM05078.1 - 6.1e-43 147.2 0.0 2.1e-23 82.8 0.1 3.1 1 1 1 2 2 2 2 Cytochrome P450 Phage_lambda_P PF06992.11 CCM05078.1 - 0.13 12.0 0.1 10 5.8 0.0 2.2 2 0 0 2 2 2 0 Replication protein P Thioredox_DsbH PF03190.15 CCM05079.1 - 3.2e-68 228.8 0.0 5.4e-68 228.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 CCM05079.1 - 1.4e-08 34.8 0.0 3.5e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like A_deaminase PF00962.22 CCM05080.1 - 5.1e-27 95.1 0.0 1.6e-25 90.2 0.0 2.5 2 1 0 2 2 2 2 Adenosine/AMP deaminase Macro_2 PF14519.6 CCM05081.1 - 1.2e-05 24.8 0.0 0.053 12.9 0.0 2.2 2 0 0 2 2 2 2 Macro-like domain Macro PF01661.21 CCM05081.1 - 0.0037 17.3 0.0 0.0061 16.6 0.0 1.4 1 0 0 1 1 1 1 Macro domain Methyltransf_25 PF13649.6 CCM05081.1 - 0.016 15.9 0.0 0.042 14.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Pkinase_Tyr PF07714.17 CCM05082.1 - 6.2e-43 146.9 0.0 9e-43 146.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM05082.1 - 2e-39 135.6 0.0 3.1e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 CCM05082.1 - 0.087 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCM05082.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 CCM05082.1 - 0.2 11.2 0.0 0.36 10.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family FAD_binding_4 PF01565.23 CCM05083.1 - 5.5e-16 58.6 0.1 9.6e-16 57.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCM05083.1 - 8.8e-10 38.5 0.4 1.9e-09 37.5 0.4 1.6 1 0 0 1 1 1 1 Berberine and berberine like Macro_2 PF14519.6 CCM05084.1 - 9.7e-05 21.8 0.1 0.013 14.9 0.1 2.5 2 1 0 2 2 2 2 Macro-like domain Methyltransf_25 PF13649.6 CCM05084.1 - 0.0097 16.6 0.0 0.029 15.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Sugar_tr PF00083.24 CCM05085.1 - 0.028 13.3 0.0 0.031 13.2 0.0 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter DUF647 PF04884.14 CCM05086.1 - 4.8e-85 285.0 2.4 7.7e-85 284.4 2.4 1.3 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis SLATT_5 PF18160.1 CCM05086.1 - 0.14 11.4 0.0 0.33 10.3 0.0 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Cu-oxidase PF00394.22 CCM05087.1 - 1.8e-42 145.1 0.0 1.7e-36 125.8 0.1 3.5 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 CCM05087.1 - 1.1e-34 119.0 4.7 2.7e-32 111.3 0.4 3.7 3 1 1 4 4 4 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 CCM05087.1 - 4.1e-34 117.3 1.7 5.2e-32 110.4 0.1 3.2 3 0 0 3 3 3 1 Multicopper oxidase FTR1 PF03239.14 CCM05088.1 - 1.2e-64 218.5 3.7 1.4e-64 218.2 3.7 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family PAC4 PF16093.5 CCM05088.1 - 0.16 12.2 0.1 1.9 8.7 0.0 2.4 2 1 0 2 2 2 0 Proteasome assembly chaperone 4 p450 PF00067.22 CCM05089.1 - 4.5e-54 183.9 0.0 5.9e-54 183.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ndr PF03096.14 CCM05089.1 - 0.21 10.3 0.0 0.38 9.4 0.0 1.3 1 0 0 1 1 1 0 Ndr family zf-C2H2_4 PF13894.6 CCM05090.1 - 4.8e-05 23.8 0.3 0.25 12.3 0.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_9 PF16293.5 CCM05090.1 - 0.0074 16.1 0.2 1.7 8.6 0.0 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (1 copy) zf-C2H2_3rep PF18868.1 CCM05090.1 - 0.017 15.8 0.4 0.29 11.8 0.3 2.0 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Ala_racemase_N PF01168.20 CCM05090.1 - 0.085 12.5 0.2 0.099 12.3 0.2 1.0 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain zinc_ribbon_9 PF14369.6 CCM05090.1 - 0.087 13.1 2.8 0.65 10.3 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon zf-Di19 PF05605.12 CCM05090.1 - 0.11 12.8 3.7 0.35 11.2 0.4 2.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding p450 PF00067.22 CCM05091.1 - 1.2e-43 149.5 0.0 1.7e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_16 PF10294.9 CCM05093.1 - 4.8e-05 23.2 0.0 0.28 10.9 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 CCM05093.1 - 0.015 15.2 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain F-box-like PF12937.7 CCM05094.1 - 0.0025 17.7 1.4 0.007 16.2 0.3 2.6 2 0 0 2 2 2 1 F-box-like DUF4336 PF14234.6 CCM05095.1 - 1.6e-14 53.8 0.0 1.2e-07 31.2 0.0 2.8 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) ChAPs PF09295.10 CCM05097.1 - 7.3e-147 489.5 0.0 1.6e-145 485.1 0.0 2.0 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 CCM05097.1 - 4.3e-09 36.8 4.9 3.3e-06 27.5 0.1 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM05097.1 - 0.0002 21.2 4.4 1 9.7 0.1 5.7 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCM05097.1 - 0.0018 17.6 3.5 0.72 9.0 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat NARP1 PF12569.8 CCM05097.1 - 0.0062 15.5 0.9 0.017 14.1 0.1 1.9 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_8 PF13181.6 CCM05097.1 - 0.0095 16.1 0.4 11 6.5 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 CCM05097.1 - 0.038 14.8 2.3 7.1 7.7 0.0 5.1 4 1 2 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM05097.1 - 0.097 12.9 11.1 0.23 11.7 1.4 4.8 5 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CCM05097.1 - 0.14 12.8 0.4 40 5.1 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Sugar_tr PF00083.24 CCM05098.1 - 4e-47 161.1 21.8 1.2e-44 152.9 21.8 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM05098.1 - 2.6e-17 62.8 36.6 4.2e-10 39.1 16.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CCM05098.1 - 5.9e-05 21.8 21.1 0.0066 15.1 4.9 3.2 2 1 1 3 3 3 3 MFS/sugar transport protein DUF5336 PF17270.2 CCM05098.1 - 0.045 13.4 1.3 0.12 12.0 0.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5336) PMT_2 PF13231.6 CCM05098.1 - 0.49 10.6 10.5 0.58 10.4 0.2 3.8 3 1 1 4 4 4 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DMT_YdcZ PF04657.13 CCM05098.1 - 4.6 7.5 24.0 0.4 10.9 2.6 4.1 4 1 0 4 4 4 0 Putative inner membrane exporter, YdcZ G-alpha PF00503.20 CCM05099.1 - 9.5e-64 215.8 0.0 1.1e-63 215.6 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit TniB PF05621.11 CCM05099.1 - 0.0027 17.2 0.0 0.0043 16.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_29 PF13555.6 CCM05099.1 - 0.013 15.3 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM05099.1 - 0.03 14.7 0.3 0.089 13.2 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain DAP3 PF10236.9 CCM05099.1 - 0.12 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.27 CCM05099.1 - 0.14 12.6 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AA_kinase PF00696.28 CCM05100.1 - 4e-39 134.7 0.0 1.5e-38 132.8 0.0 1.9 1 1 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 CCM05100.1 - 1.2e-10 41.0 0.7 0.0001 22.0 0.1 3.1 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.6 CCM05100.1 - 3.2e-08 33.2 0.7 1.1e-05 25.1 0.1 2.7 2 0 0 2 2 2 2 ACT domain Sugar_tr PF00083.24 CCM05101.1 - 1.3e-41 142.9 27.6 8.6e-40 136.9 27.5 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM05101.1 - 8.3e-16 57.9 39.0 6.1e-10 38.5 17.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 CCM05101.1 - 0.016 13.5 1.3 0.46 8.7 0.3 2.3 2 0 0 2 2 2 0 BT1 family TRI12 PF06609.13 CCM05101.1 - 0.032 12.6 5.9 0.016 13.7 2.0 2.0 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DUF4387 PF14330.6 CCM05102.1 - 2.6e-35 121.0 0.0 5e-35 120.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4387) AtuA PF07287.11 CCM05102.1 - 1.3e-15 57.1 0.0 5.2e-14 51.7 0.0 2.2 1 1 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA MFS_1 PF07690.16 CCM05103.1 - 9.3e-20 70.8 75.5 3.8e-16 59.0 43.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 CCM05104.1 - 2.5e-58 196.8 0.1 2.9e-58 196.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05104.1 - 2.3e-57 194.2 0.2 2.7e-57 194.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05104.1 - 1.1e-08 35.3 0.3 1.6e-08 34.7 0.3 1.2 1 0 0 1 1 1 1 KR domain Transketolase_C PF02780.20 CCM05104.1 - 0.079 12.8 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Transketolase, C-terminal domain Epimerase PF01370.21 CCM05104.1 - 0.099 12.1 0.0 0.18 11.2 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCM05104.1 - 0.14 12.0 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 CCM05105.1 - 6.6e-42 143.2 1.9 6.5e-36 123.6 1.3 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05105.1 - 2.9e-40 138.3 0.7 2e-29 102.8 0.4 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05105.1 - 2e-10 40.9 0.8 3.3e-10 40.2 0.6 1.4 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 CCM05106.1 - 1.4e-55 187.8 4.1 1.8e-55 187.5 4.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05106.1 - 2e-54 184.6 2.6 2.5e-54 184.3 2.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05106.1 - 2.4e-08 34.1 3.5 3.4e-08 33.6 3.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM05106.1 - 0.021 14.3 0.5 0.036 13.5 0.5 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family HHH_5 PF14520.6 CCM05106.1 - 0.042 14.5 0.4 0.2 12.3 0.2 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain 3HCDH_N PF02737.18 CCM05106.1 - 0.11 12.4 0.9 0.18 11.7 0.9 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UPF0254 PF06787.11 CCM05106.1 - 0.75 9.5 7.7 0.11 12.2 1.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0254) C1_1 PF00130.22 CCM05109.1 - 0.035 14.0 1.0 0.072 13.0 1.0 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 CCM05109.1 - 0.043 14.2 1.3 0.1 13.0 1.3 1.6 1 0 0 1 1 1 0 Ring finger domain FANCL_C PF11793.8 CCM05109.1 - 0.35 11.1 1.2 0.8 9.9 1.2 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain NARP1 PF12569.8 CCM05111.1 - 7.6e-157 523.3 4.6 8.6e-156 519.8 1.2 2.4 3 0 0 3 3 3 1 NMDA receptor-regulated protein 1 TPR_16 PF13432.6 CCM05111.1 - 1.9e-13 50.8 2.6 0.52 11.0 0.4 8.2 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCM05111.1 - 5.5e-13 48.0 5.0 0.0089 16.1 0.0 8.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM05111.1 - 2.2e-10 40.9 18.3 0.0096 16.4 0.1 8.3 6 3 2 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 CCM05111.1 - 7.1e-09 35.8 12.3 2.8 9.0 0.2 10.2 7 3 5 12 12 11 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCM05111.1 - 6.8e-08 32.0 6.4 0.0059 16.4 0.2 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCM05111.1 - 1.5e-07 31.0 1.8 0.0044 16.7 0.3 4.2 4 0 0 4 4 4 2 TPR repeat TPR_8 PF13181.6 CCM05111.1 - 5.5e-06 26.2 10.0 0.0099 16.0 0.1 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCM05111.1 - 0.00045 20.3 7.0 26 5.1 0.0 6.2 5 1 1 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM05111.1 - 0.00057 20.1 4.7 1.6 9.0 0.0 4.6 4 2 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CCM05111.1 - 0.0013 18.6 0.5 2 8.6 0.0 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM05111.1 - 0.0019 18.5 9.7 1.3 9.4 0.1 5.6 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 CCM05111.1 - 0.033 14.8 4.7 1.9 9.4 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat BTAD PF03704.17 CCM05111.1 - 0.16 12.4 6.0 0.23 11.9 0.6 3.6 3 1 0 3 3 3 0 Bacterial transcriptional activator domain TPR_MalT PF17874.1 CCM05111.1 - 4.3 6.6 9.4 0.44 9.9 0.1 3.5 4 1 0 4 4 4 0 MalT-like TPR region TPR_6 PF13174.6 CCM05111.1 - 7.2 7.5 12.1 2.2e+02 2.8 0.0 7.1 8 0 0 8 8 7 0 Tetratricopeptide repeat CLASP_N PF12348.8 CCM05112.1 - 5.1e-06 26.2 1.5 0.066 12.8 0.0 4.7 3 2 1 4 4 4 1 CLASP N terminal Cnd1 PF12717.7 CCM05112.1 - 1.5e-05 25.1 1.5 0.36 10.8 0.0 4.3 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CCM05112.1 - 0.0003 20.8 3.1 2.2 8.8 0.0 5.5 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 CCM05112.1 - 0.019 15.5 0.6 1.7 9.3 0.0 4.0 3 0 0 3 3 3 0 HEAT-like repeat Adaptin_N PF01602.20 CCM05112.1 - 0.043 12.4 0.3 3.4 6.1 0.2 2.8 2 1 1 3 3 3 0 Adaptin N terminal region DUF1416 PF07210.12 CCM05112.1 - 0.06 13.2 0.0 0.22 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1416) Ribosomal_L44 PF00935.19 CCM05113.1 - 1e-34 118.8 10.2 1e-34 118.8 10.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L44 Cathelicidins PF00666.17 CCM05113.1 - 0.02 15.2 0.3 0.038 14.3 0.3 1.4 1 0 0 1 1 1 0 Cathelicidin Pkinase PF00069.25 CCM05114.1 - 1.1e-67 228.2 0.0 1.4e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05114.1 - 1.1e-29 103.6 0.0 1.6e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CCM05114.1 - 0.00029 19.9 0.0 0.00042 19.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain PLA2_B PF01735.18 CCM05117.1 - 7.9e-99 331.3 0.0 9.5e-99 331.0 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Patatin PF01734.22 CCM05117.1 - 0.016 15.4 0.6 0.035 14.3 0.4 1.7 2 0 0 2 2 2 0 Patatin-like phospholipase PLA2_B PF01735.18 CCM05118.1 - 8.9e-96 321.2 0.0 1.1e-95 320.9 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Patatin PF01734.22 CCM05118.1 - 4.6e-05 23.7 0.1 0.00012 22.4 0.1 1.8 2 0 0 2 2 2 1 Patatin-like phospholipase Aminotran_1_2 PF00155.21 CCM05119.1 - 5.8e-36 124.4 0.0 3.4e-34 118.6 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCM05119.1 - 3.2e-06 26.7 0.0 4.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CCM05119.1 - 9.7e-06 24.3 0.0 1.4e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CCM05119.1 - 0.0038 16.6 0.0 0.0056 16.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CCM05119.1 - 0.034 13.1 0.0 0.061 12.3 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V DUF836 PF05768.14 CCM05120.1 - 4.8e-13 49.3 0.0 8.9e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 CCM05120.1 - 0.003 17.6 0.0 0.0057 16.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin domain zf-CCHC PF00098.23 CCM05120.1 - 0.18 11.9 0.5 0.33 11.1 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF1077 PF06417.12 CCM05121.1 - 0.088 12.8 0.1 1.6 8.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1077) MFS_1 PF07690.16 CCM05122.1 - 4.3e-36 124.6 32.8 4.3e-36 124.6 32.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM05122.1 - 2.4e-14 53.1 26.9 3.5e-14 52.5 26.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 CCM05122.1 - 0.01 14.2 6.1 0.028 12.7 6.0 1.7 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family RNase_H PF00075.24 CCM05124.1 - 1.4e-31 109.6 0.0 9.3e-31 106.9 0.0 2.0 2 0 0 2 2 2 1 RNase H Cauli_VI PF01693.16 CCM05124.1 - 2e-20 72.8 0.6 3.7e-20 72.0 0.6 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin adh_short_C2 PF13561.6 CCM05125.1 - 4.9e-60 203.0 1.4 6.9e-60 202.5 1.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM05125.1 - 5.7e-54 182.5 0.3 6.8e-54 182.3 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM05125.1 - 3.8e-10 40.0 0.8 5.7e-10 39.4 0.8 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CCM05125.1 - 0.013 15.4 0.1 0.11 12.4 0.3 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 CCM05125.1 - 0.052 13.0 0.5 0.081 12.4 0.5 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family APH PF01636.23 CCM05127.1 - 3e-05 24.1 0.0 0.00014 21.9 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM05127.1 - 5e-05 23.0 0.1 0.0025 17.5 0.0 2.1 1 1 1 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 CCM05127.1 - 0.00019 21.1 0.0 0.00029 20.5 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 CCM05127.1 - 0.0011 18.3 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF5323 PF17257.2 CCM05127.1 - 0.037 13.9 0.9 0.072 13.0 0.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5323) Pkinase PF00069.25 CCM05127.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Ufm1 PF03671.14 CCM05127.1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fold modifier 1 protein AP_endonuc_2 PF01261.24 CCM05128.1 - 4.2e-29 101.5 0.0 7.1e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Caerin_1 PF07440.12 CCM05128.1 - 0.16 12.1 0.2 0.44 10.7 0.2 1.7 1 0 0 1 1 1 0 Caerin 1 protein Clathrin PF00637.20 CCM05130.1 - 1.7e-16 60.4 0.2 3.6e-14 52.9 0.3 2.8 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.8 CCM05130.1 - 3.2e-09 36.9 0.4 7e-09 35.8 0.4 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 CCM05130.1 - 1.2e-07 31.6 8.5 2.4e-07 30.7 8.5 1.5 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 CCM05130.1 - 0.00088 19.1 8.6 0.0019 18.0 8.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Vps39_1 PF10366.9 CCM05130.1 - 0.0073 16.6 0.1 0.056 13.7 0.0 2.6 2 2 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 zf-RING_2 PF13639.6 CCM05130.1 - 0.014 15.7 8.1 0.014 15.7 8.1 2.0 2 0 0 2 2 2 0 Ring finger domain GlnD_UR_UTase PF08335.11 CCM05130.1 - 0.014 15.5 1.0 0.034 14.2 1.0 1.6 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase zf-RING_UBOX PF13445.6 CCM05130.1 - 0.076 13.0 6.6 0.18 11.8 6.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 CCM05130.1 - 0.31 11.1 8.0 0.53 10.3 8.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain IgG_binding_B PF01378.17 CCM05130.1 - 0.6 10.2 7.6 0.34 11.0 1.1 2.8 3 0 0 3 3 3 0 B domain zf-rbx1 PF12678.7 CCM05130.1 - 1.7 9.0 8.0 4 7.8 8.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain NUDE_C PF04880.13 CCM05130.1 - 6 7.3 7.4 20 5.6 7.4 1.8 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region zf-C3HC4 PF00097.25 CCM05130.1 - 6.2 6.8 7.5 12 5.9 7.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_9 PF13901.6 CCM05130.1 - 8.6 6.3 8.8 7.2 6.5 3.8 2.3 1 1 1 2 2 2 0 Putative zinc-RING and/or ribbon ParA PF10609.9 CCM05131.1 - 1.8e-79 266.7 0.1 2.2e-79 266.4 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CCM05131.1 - 2.5e-11 43.7 0.0 7.8e-11 42.1 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CCM05131.1 - 2.9e-08 33.9 0.5 9.5e-06 25.6 0.2 2.1 2 0 0 2 2 2 2 AAA domain MipZ PF09140.11 CCM05131.1 - 0.00059 19.2 0.1 0.0012 18.2 0.0 1.5 2 0 0 2 2 2 1 ATPase MipZ AAA_25 PF13481.6 CCM05131.1 - 0.0015 18.2 0.6 0.0025 17.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 CCM05131.1 - 0.0035 16.6 3.7 0.014 14.6 1.8 2.2 2 1 1 3 3 3 1 Anion-transporting ATPase Fer4_NifH PF00142.18 CCM05131.1 - 0.096 12.1 0.2 0.21 11.0 0.2 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family NAD_binding_10 PF13460.6 CCM05132.1 - 1.3e-11 44.8 0.0 6.5e-06 26.2 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding adh_short PF00106.25 CCM05132.1 - 0.0034 16.8 0.0 0.0046 16.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05132.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase ApbA PF02558.16 CCM05132.1 - 0.2 11.3 0.0 0.48 10.0 0.0 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Abhydrolase_6 PF12697.7 CCM05133.1 - 6.2e-09 36.8 2.2 1.2e-08 35.9 2.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CCM05133.1 - 0.0017 18.1 0.0 0.0028 17.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 CCM05133.1 - 0.0069 16.3 0.0 0.022 14.6 0.0 1.8 2 0 0 2 2 2 1 Serine hydrolase Lipase_3 PF01764.25 CCM05133.1 - 0.096 12.6 0.0 12 5.8 0.0 2.2 2 0 0 2 2 2 0 Lipase (class 3) Lactamase_B_3 PF13483.6 CCM05133.1 - 0.14 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain zf-C2H2 PF00096.26 CCM05134.1 - 1.1e-05 25.6 1.0 0.024 15.1 0.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM05134.1 - 5.1e-05 23.8 1.4 0.069 14.0 0.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCM05134.1 - 0.0026 18.0 0.6 0.099 13.0 0.3 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 CCM05134.1 - 0.13 12.5 1.7 0.78 10.1 1.8 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CCM05134.1 - 0.24 11.7 1.1 2.7 8.4 1.0 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) BTB PF00651.31 CCM05135.1 - 4.1e-07 30.2 0.0 2.6e-06 27.6 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain zf-RING_2 PF13639.6 CCM05137.1 - 3.7e-06 27.2 6.9 3.7e-06 27.2 6.9 2.1 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.29 CCM05137.1 - 2.8e-05 23.9 7.2 6.6e-05 22.7 7.2 1.7 1 1 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 CCM05137.1 - 0.00033 20.5 3.5 0.00033 20.5 3.5 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 1 FANCL_C PF11793.8 CCM05137.1 - 0.00044 20.4 5.6 0.00044 20.4 5.6 2.0 2 0 0 2 2 2 1 FANCL C-terminal domain SWIM PF04434.17 CCM05137.1 - 0.0012 18.4 0.2 0.0025 17.4 0.2 1.5 1 0 0 1 1 1 1 SWIM zinc finger PHD_2 PF13831.6 CCM05137.1 - 0.0087 15.6 5.0 0.041 13.5 5.1 2.1 1 1 0 1 1 1 1 PHD-finger EURL PF06937.11 CCM05137.1 - 0.012 15.0 0.2 0.021 14.2 0.2 1.4 1 0 0 1 1 1 0 EURL protein C1_1 PF00130.22 CCM05137.1 - 0.029 14.2 4.0 0.029 14.2 4.0 2.2 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF1360 PF07098.11 CCM05137.1 - 0.15 12.0 0.1 0.44 10.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) zf-PHD-like PF15446.6 CCM05137.1 - 0.17 11.5 6.6 0.11 12.1 3.0 2.4 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD_4 PF16866.5 CCM05137.1 - 1 9.5 7.2 23 5.2 7.2 2.8 1 1 1 2 2 2 0 PHD-finger zf-RING_UBOX PF13445.6 CCM05137.1 - 1.4 9.0 5.5 4.6 7.4 5.5 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCM05137.1 - 3 7.8 8.6 24 4.9 8.6 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 CCM05137.1 - 7.2 7.0 9.6 0.41 11.0 2.9 2.5 3 0 0 3 3 3 0 RING-like domain CHAT PF12770.7 CCM05138.1 - 1.2e-33 116.8 0.1 2.6e-33 115.7 0.0 1.6 2 0 0 2 2 2 1 CHAT domain TPR_8 PF13181.6 CCM05138.1 - 0.00012 22.0 3.2 19 5.8 0.0 8.4 10 1 1 11 11 11 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCM05138.1 - 0.0011 18.7 7.7 5.7 6.9 0.0 7.4 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM05138.1 - 0.0011 18.9 11.2 11 6.4 0.1 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCM05138.1 - 0.0022 18.6 6.5 3.9 8.2 0.1 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCM05138.1 - 0.0039 17.9 13.0 27 5.9 0.1 7.8 7 2 1 8 8 8 0 Tetratricopeptide repeat Gp49 PF05973.14 CCM05138.1 - 0.032 14.4 0.0 9.3 6.5 0.0 2.6 2 0 0 2 2 2 0 Phage derived protein Gp49-like (DUF891) TPR_6 PF13174.6 CCM05138.1 - 0.85 10.4 8.7 26 5.7 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat IIGP PF05049.13 CCM05139.1 - 3e-21 75.9 0.0 3e-21 75.9 0.0 1.6 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 CCM05139.1 - 1.4e-05 25.1 0.3 4.2e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM05139.1 - 0.0022 17.9 0.0 0.0054 16.7 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CCM05139.1 - 0.0028 17.4 1.6 0.0046 16.7 0.1 2.1 3 0 0 3 3 3 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CCM05139.1 - 0.024 15.1 0.1 0.024 15.1 0.1 3.3 3 1 0 3 3 3 0 ABC transporter FtsK_SpoIIIE PF01580.18 CCM05139.1 - 0.045 13.1 1.0 0.07 12.5 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.13 CCM05139.1 - 0.052 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 CCM05139.1 - 0.056 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM05139.1 - 0.35 10.3 0.1 0.35 10.3 0.1 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM05139.1 - 0.65 10.5 0.0 0.65 10.5 0.0 3.7 3 1 0 3 3 3 0 AAA domain IIGP PF05049.13 CCM05140.1 - 3.9e-20 72.2 0.0 6.1e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 CCM05140.1 - 5.9e-05 23.1 0.0 0.00016 21.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CCM05140.1 - 0.0041 17.0 0.0 0.0084 16.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CCM05140.1 - 0.014 15.1 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 CCM05140.1 - 0.024 14.9 0.0 0.055 13.7 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 CCM05140.1 - 0.032 14.7 0.0 0.032 14.7 0.0 3.0 3 1 0 3 3 3 0 ABC transporter AAA_21 PF13304.6 CCM05140.1 - 0.089 12.6 0.0 0.3 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MctB PF11382.8 CCM05140.1 - 0.17 11.6 0.1 0.17 11.6 0.1 2.8 3 1 0 3 3 3 0 Copper transport outer membrane protein, MctB AAA_16 PF13191.6 CCM05140.1 - 0.88 9.9 0.0 0.88 9.9 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain p450 PF00067.22 CCM05142.1 - 5e-09 35.4 0.0 5.6e-09 35.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Acetyltransf_1 PF00583.25 CCM05143.1 - 3.8e-12 46.5 0.1 5.5e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CCM05143.1 - 2e-07 31.0 0.0 3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM05143.1 - 6.7e-07 29.6 0.2 1.3e-06 28.7 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCM05143.1 - 8.4e-07 28.9 0.0 1.3e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CCM05143.1 - 0.00049 20.3 0.0 0.00085 19.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NUC153 PF08159.12 CCM05143.1 - 0.042 13.7 0.1 0.16 11.8 0.1 2.0 1 0 0 1 1 1 0 NUC153 domain PanZ PF12568.8 CCM05143.1 - 0.044 13.5 0.1 0.069 12.9 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 CCM05143.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase ESSS PF10183.9 CCM05144.1 - 2.3e-12 47.1 0.0 2.4e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) GTP_EFTU PF00009.27 CCM05145.1 - 1.3e-56 191.2 0.3 2.3e-56 190.5 0.3 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GCV_H PF01597.19 CCM05145.1 - 7.6e-38 129.1 0.1 1.5e-37 128.2 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein GTP_EFTU_D3 PF03143.17 CCM05145.1 - 8.9e-23 80.7 0.0 2.4e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CCM05145.1 - 7.7e-18 64.7 3.5 1.7e-17 63.5 3.5 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CCM05145.1 - 0.00013 22.1 0.1 0.00052 20.1 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Biotin_lipoyl PF00364.22 CCM05145.1 - 0.002 17.9 2.9 0.0032 17.3 0.1 2.8 3 0 0 3 3 3 1 Biotin-requiring enzyme RnfC_N PF13375.6 CCM05145.1 - 0.0052 16.7 0.1 0.016 15.2 0.1 1.8 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain cobW PF02492.19 CCM05145.1 - 0.0062 16.1 0.5 0.012 15.3 0.0 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 CCM05145.1 - 0.0078 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase PduV-EutP PF10662.9 CCM05145.1 - 0.037 13.8 0.7 5.4 6.8 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 CCM05145.1 - 0.23 10.8 0.3 0.74 9.1 0.3 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Pex14_N PF04695.13 CCM05146.1 - 1.1e-22 81.4 7.7 1.1e-22 81.4 7.7 3.0 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region ING PF12998.7 CCM05146.1 - 2.2e-05 25.0 6.5 5.5e-05 23.7 6.5 1.6 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding DUF1759 PF03564.15 CCM05146.1 - 0.00076 19.4 3.0 0.0009 19.2 0.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1759) zf-C4H2 PF10146.9 CCM05146.1 - 0.0015 18.9 1.9 0.0015 18.9 1.9 1.6 2 0 0 2 2 1 1 Zinc finger-containing protein MIF4G_like_2 PF09090.11 CCM05146.1 - 0.0025 17.4 1.9 0.0035 16.9 1.9 1.2 1 0 0 1 1 1 1 MIF4G like Imm49 PF15575.6 CCM05146.1 - 0.003 17.4 0.2 0.0039 17.0 0.2 1.3 1 0 0 1 1 1 1 Immunity protein 49 Zwint PF15556.6 CCM05146.1 - 0.0038 16.8 6.8 0.0061 16.1 6.8 1.2 1 0 0 1 1 1 1 ZW10 interactor DUF848 PF05852.11 CCM05146.1 - 0.0046 17.1 1.5 0.0085 16.2 1.5 1.5 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) Med9 PF07544.13 CCM05146.1 - 0.0081 16.2 10.5 0.38 10.9 5.4 2.6 1 1 1 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 FapA PF03961.13 CCM05146.1 - 0.017 13.7 2.9 0.024 13.3 2.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Mt_ATP-synt_D PF05873.12 CCM05146.1 - 0.019 14.8 7.6 0.063 13.1 7.4 1.9 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Methyltransf_14 PF08484.11 CCM05146.1 - 0.019 14.7 2.7 0.033 14.0 2.7 1.3 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain RasGEF_N_2 PF14663.6 CCM05146.1 - 0.021 15.2 1.2 0.45 10.9 1.2 2.3 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain BshC PF10079.9 CCM05146.1 - 0.029 13.1 5.3 0.04 12.7 5.3 1.3 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC UvrD_C PF13361.6 CCM05146.1 - 0.029 13.7 0.4 0.037 13.4 0.4 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain CEP63 PF17045.5 CCM05146.1 - 0.03 14.2 11.2 0.061 13.2 11.2 1.5 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa PSII_Pbs27 PF13326.6 CCM05146.1 - 0.033 14.5 0.4 0.056 13.8 0.4 1.4 1 0 0 1 1 1 0 Photosystem II Pbs27 V_ATPase_I PF01496.19 CCM05146.1 - 0.041 11.8 0.1 0.04 11.9 0.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pox_F16 PF04708.12 CCM05146.1 - 0.047 13.1 0.1 0.073 12.5 0.1 1.2 1 0 0 1 1 1 0 Poxvirus F16 protein Golgin_A5 PF09787.9 CCM05146.1 - 0.064 12.7 10.7 0.11 12.0 10.7 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 CCM05146.1 - 0.068 12.7 1.7 0.11 12.0 1.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1690 PF07956.11 CCM05146.1 - 0.076 13.4 6.2 0.15 12.5 6.2 1.5 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Rsd_AlgQ PF04353.13 CCM05146.1 - 0.089 12.7 5.2 0.066 13.2 2.9 1.8 1 1 1 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ Nmad5 PF18757.1 CCM05146.1 - 0.09 13.0 5.8 0.96 9.6 0.2 2.3 1 1 1 2 2 2 0 Nucleotide modification associated domain 5 Tho2 PF11262.8 CCM05146.1 - 0.097 11.9 2.2 0.15 11.2 2.2 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 TMPIT PF07851.13 CCM05146.1 - 0.1 11.8 5.3 0.16 11.2 5.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 CCM05146.1 - 0.13 11.6 2.1 0.22 10.9 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HMMR_N PF15905.5 CCM05146.1 - 0.13 11.7 12.4 0.046 13.2 9.6 1.5 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal APG17 PF04108.12 CCM05146.1 - 0.13 11.3 9.1 0.19 10.8 9.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 LMBR1 PF04791.16 CCM05146.1 - 0.13 11.1 0.8 0.17 10.8 0.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_32 PF13654.6 CCM05146.1 - 0.14 10.9 9.2 0.25 10.1 9.2 1.3 1 0 0 1 1 1 0 AAA domain LXG PF04740.12 CCM05146.1 - 0.16 11.7 9.3 0.28 10.9 9.3 1.3 1 0 0 1 1 1 0 LXG domain of WXG superfamily GAS PF13851.6 CCM05146.1 - 0.17 11.2 17.1 0.42 9.9 9.4 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 CCM05146.1 - 0.18 10.6 13.6 0.31 9.9 13.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein IFT57 PF10498.9 CCM05146.1 - 0.18 10.7 10.9 0.28 10.1 6.8 1.9 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Prominin PF05478.11 CCM05146.1 - 0.19 9.7 3.2 0.27 9.1 3.2 1.2 1 0 0 1 1 1 0 Prominin HOOK PF05622.12 CCM05146.1 - 0.2 9.7 12.4 0.34 9.0 12.4 1.3 1 0 0 1 1 1 0 HOOK protein PCRF PF03462.18 CCM05146.1 - 0.22 11.4 6.4 0.45 10.4 6.4 1.5 1 0 0 1 1 1 0 PCRF domain DUF948 PF06103.11 CCM05146.1 - 0.26 11.5 4.9 0.93 9.8 4.9 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Noelin-1 PF12308.8 CCM05146.1 - 0.27 11.2 4.9 0.32 11.0 2.5 2.1 1 1 1 2 2 2 0 Neurogenesis glycoprotein Z1 PF10593.9 CCM05146.1 - 0.29 10.6 3.4 0.44 10.0 3.4 1.2 1 0 0 1 1 1 0 Z1 domain Laminin_II PF06009.12 CCM05146.1 - 0.36 10.8 13.6 0.083 12.9 9.8 1.8 2 0 0 2 2 2 0 Laminin Domain II AAA_13 PF13166.6 CCM05146.1 - 0.44 9.1 6.3 0.6 8.7 6.3 1.1 1 0 0 1 1 1 0 AAA domain YkuI_C PF10388.9 CCM05146.1 - 0.63 9.8 3.8 23 4.8 0.0 2.9 3 1 1 4 4 3 0 EAL-domain associated signalling protein domain Phage_GPO PF05929.11 CCM05146.1 - 0.69 9.5 6.8 1.3 8.6 6.8 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Gastrin PF00918.17 CCM05146.1 - 0.72 10.8 3.9 1.4 9.8 3.9 1.5 1 0 0 1 1 1 0 Gastrin/cholecystokinin family Aida_N PF08910.10 CCM05146.1 - 0.78 10.2 4.3 1.5 9.2 4.3 1.5 1 0 0 1 1 1 0 Aida N-terminus THOC7 PF05615.13 CCM05146.1 - 0.8 10.0 13.1 0.5 10.6 10.3 1.9 1 1 1 2 2 2 0 Tho complex subunit 7 Occludin_ELL PF07303.13 CCM05146.1 - 0.89 10.3 7.2 1.5 9.6 6.5 1.7 1 1 0 1 1 1 0 Occludin homology domain DUF334 PF03904.13 CCM05146.1 - 0.89 9.0 8.5 0.16 11.5 4.8 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF334) UPF0242 PF06785.11 CCM05146.1 - 0.92 9.6 10.0 1.6 8.8 10.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 CCM05146.1 - 1 9.5 7.1 1.9 8.6 7.1 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 CCM05146.1 - 1.5 8.9 13.0 11 6.0 11.4 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) CC2-LZ PF16516.5 CCM05146.1 - 1.7 9.0 13.8 0.11 12.9 1.3 2.9 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4854 PF16146.5 CCM05146.1 - 1.8 8.9 6.7 22 5.4 2.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4854) YojJ PF10372.9 CCM05146.1 - 2.1 8.5 6.0 1.1 9.4 2.5 2.2 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus Csm1_N PF18504.1 CCM05146.1 - 2.9 8.3 15.1 0.29 11.5 6.5 2.7 1 1 2 3 3 3 0 Csm1 N-terminal domain TSNAXIP1_N PF15739.5 CCM05146.1 - 4 7.9 11.0 1.2 9.5 7.3 2.0 2 1 0 2 2 1 0 Translin-associated factor X-interacting N-terminus FUSC PF04632.12 CCM05146.1 - 4 5.9 5.0 11 4.4 4.8 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF3450 PF11932.8 CCM05146.1 - 4.2 6.6 14.8 4.6 6.5 10.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) COG2 PF06148.11 CCM05146.1 - 4.7 7.3 12.1 3.9 7.6 7.1 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.12 CCM05146.1 - 9.4 6.8 15.0 2.7 8.5 6.4 3.5 3 1 1 4 4 2 0 Nucleopolyhedrovirus P10 protein GRIP PF01465.20 CCM05148.1 - 7.9e-06 25.7 0.1 2.8e-05 23.9 0.1 2.0 1 0 0 1 1 1 1 GRIP domain Cation_efflux PF01545.21 CCM05149.1 - 9.5e-52 175.6 9.0 2.3e-51 174.4 9.0 1.6 1 1 0 1 1 1 1 Cation efflux family MASE4 PF17158.4 CCM05149.1 - 0.0073 15.6 1.3 0.0073 15.6 1.3 1.7 1 1 0 1 1 1 1 Membrane-associated sensor, integral membrane domain JAB PF01398.21 CCM05150.1 - 4.8e-12 45.9 0.0 8.3e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DPBB_1 PF03330.18 CCM05151.1 - 3.5e-05 24.0 0.5 0.00017 21.8 0.5 2.2 1 1 0 1 1 1 1 Lytic transglycolase Ipi1_N PF12333.8 CCM05152.1 - 3.7e-21 75.6 0.0 3e-19 69.5 0.0 3.2 1 1 2 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation HEAT_2 PF13646.6 CCM05152.1 - 0.0018 18.6 1.5 0.029 14.7 0.1 2.9 3 0 0 3 3 3 1 HEAT repeats Cellulase PF00150.18 CCM05153.1 - 1.3e-17 64.1 0.2 1.9e-17 63.6 0.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4038 PF13204.6 CCM05153.1 - 1.2e-06 28.5 1.7 1.8e-06 27.8 1.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4038) RNase_T PF00929.24 CCM05154.1 - 5.1e-28 98.7 0.0 8e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease E1_DerP2_DerF2 PF02221.15 CCM05154.1 - 3.1e-24 85.9 0.1 4.8e-24 85.3 0.1 1.3 1 0 0 1 1 1 1 ML domain Tetraspanin PF00335.20 CCM05155.1 - 0.0024 17.6 5.5 0.0029 17.4 4.6 1.5 2 0 0 2 2 2 1 Tetraspanin family MRAP PF15183.6 CCM05155.1 - 0.032 14.2 0.2 0.22 11.5 0.1 2.1 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family ADH_N PF08240.12 CCM05158.1 - 1e-29 102.6 0.8 1.6e-29 102.0 0.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM05158.1 - 2.7e-12 46.8 0.0 7.9e-09 35.6 0.0 2.3 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Methyltransf_31 PF13847.6 CCM05158.1 - 0.00011 22.0 0.0 0.00018 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain 2-Hacid_dh_C PF02826.19 CCM05158.1 - 0.00069 19.0 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCM05158.1 - 0.0032 17.7 0.0 0.0049 17.1 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Methyltransf_25 PF13649.6 CCM05158.1 - 0.009 16.7 0.0 0.019 15.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM05158.1 - 0.016 15.8 0.0 0.039 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain FANCL_C PF11793.8 CCM05158.1 - 0.062 13.5 0.4 0.13 12.5 0.4 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain SGL PF08450.12 CCM05159.1 - 3.3e-44 151.3 0.0 4.7e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Ribosomal_L17 PF01196.19 CCM05159.1 - 1.7e-32 112.1 0.0 3.3e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L17 PP-binding PF00550.25 CCM05159.1 - 2.7e-12 46.9 0.3 5e-12 46.0 0.3 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CCM05159.1 - 2.4e-08 34.1 0.8 4.6e-08 33.2 0.5 1.6 1 1 0 1 1 1 1 Acyl-carrier Arylesterase PF01731.20 CCM05159.1 - 0.0028 17.8 0.0 0.015 15.5 0.0 2.0 2 0 0 2 2 2 1 Arylesterase Ribosomal_L13 PF00572.18 CCM05160.1 - 1.1e-11 45.0 0.0 2.9e-09 37.2 0.0 2.3 1 1 1 2 2 2 2 Ribosomal protein L13 KH_1 PF00013.29 CCM05161.1 - 6.6e-42 141.2 7.9 2.3e-16 59.4 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CCM05161.1 - 4.6e-10 39.2 1.6 0.012 15.4 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CCM05161.1 - 5.2e-10 39.1 1.7 0.011 15.6 0.0 3.6 3 1 1 4 4 4 3 KH domain KH_5 PF13184.6 CCM05161.1 - 1.3e-05 25.2 2.8 0.021 14.9 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain NUFIP1 PF10453.9 CCM05162.1 - 5.3e-19 67.8 0.2 1e-18 66.9 0.2 1.5 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Peptidase_M16_C PF05193.21 CCM05163.1 - 3e-14 53.4 0.0 2.8e-09 37.2 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CCM05163.1 - 2.8e-06 27.4 0.0 0.0002 21.4 0.0 2.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 CCM05163.1 - 0.0013 18.0 4.3 0.038 13.1 4.3 2.2 1 1 0 1 1 1 1 Peptidase M16C associated DUF2205 PF10224.9 CCM05163.1 - 2.2 8.3 5.5 4 7.5 1.2 3.0 3 0 0 3 3 3 0 Short coiled-coil protein PDT PF00800.18 CCM05164.1 - 4.1e-45 153.8 0.0 1.4e-43 148.9 0.0 2.1 1 1 0 1 1 1 1 Prephenate dehydratase p450 PF00067.22 CCM05165.1 - 1.9e-51 175.2 0.0 7.4e-51 173.3 0.0 1.7 2 0 0 2 2 2 1 Cytochrome P450 zf-CCCH PF00642.24 CCM05166.1 - 2.5e-16 59.1 28.5 2.4e-05 24.1 0.6 4.9 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CCM05166.1 - 1.5e-10 40.8 30.7 9.7e-07 28.7 2.1 4.8 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 CCM05166.1 - 1.2e-07 32.4 20.5 0.00033 21.3 0.2 4.7 1 1 4 5 5 5 4 Torus domain zf-CCCH_4 PF18044.1 CCM05166.1 - 2.3e-05 24.0 0.4 2.3e-05 24.0 0.4 4.6 6 0 0 6 6 6 1 CCCH-type zinc finger zf-CCHC PF00098.23 CCM05166.1 - 7.5e-05 22.6 4.3 0.00025 21.0 4.3 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-CCCH_2 PF14608.6 CCM05166.1 - 0.0054 17.1 29.1 0.008 16.6 0.3 5.1 5 0 0 5 5 5 3 RNA-binding, Nab2-type zinc finger zf-CCHC_3 PF13917.6 CCM05166.1 - 0.0086 16.0 1.1 0.023 14.7 1.1 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 CCM05166.1 - 0.028 14.2 3.6 0.15 11.9 3.6 2.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCCH_3 PF15663.5 CCM05166.1 - 6.7 7.0 15.8 2.3 8.5 0.4 3.2 2 1 2 4 4 4 0 Zinc-finger containing family Fungal_trans PF04082.18 CCM05167.1 - 2e-10 40.2 0.0 3e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain UPF0047 PF01894.17 CCM05168.1 - 9.3e-17 61.2 0.0 1.1e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 RhoGEF PF00621.20 CCM05170.1 - 1.8e-15 57.7 0.0 3.2e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain GAPES3 PF17154.4 CCM05170.1 - 0.052 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain Exo_endo_phos PF03372.23 CCM05171.1 - 1.1e-13 51.2 0.1 2.1e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Acyltransferase PF01553.21 CCM05171.1 - 0.037 13.6 0.0 0.098 12.3 0.0 1.7 2 0 0 2 2 2 0 Acyltransferase Ras PF00071.22 CCM05172.1 - 4.4e-39 133.7 0.0 5.3e-39 133.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM05172.1 - 2.1e-12 47.3 0.0 2.9e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CCM05172.1 - 0.0042 16.6 0.0 0.005 16.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CCM05172.1 - 0.037 13.5 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family His_Phos_1 PF00300.22 CCM05173.1 - 6.1e-40 137.0 0.1 7.5e-40 136.7 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TMF_TATA_bd PF12325.8 CCM05174.1 - 0.0016 18.6 8.3 0.0016 18.6 8.3 9.6 1 1 8 10 10 10 2 TATA element modulatory factor 1 TATA binding DUF724 PF05266.14 CCM05174.1 - 0.0032 17.3 14.4 0.0032 17.3 14.4 6.9 2 1 5 7 7 7 3 Protein of unknown function (DUF724) DUF3450 PF11932.8 CCM05174.1 - 0.0052 16.1 12.7 0.0052 16.1 12.7 8.3 2 2 5 8 8 8 2 Protein of unknown function (DUF3450) F-box-like PF12937.7 CCM05175.1 - 5.8e-05 22.9 0.1 0.00023 21.0 0.1 2.1 2 0 0 2 2 2 1 F-box-like Mito_carr PF00153.27 CCM05176.1 - 3.4e-30 103.8 9.0 1.5e-15 56.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mpv17_PMP22 PF04117.12 CCM05177.1 - 1e-10 41.7 1.2 2.2e-10 40.6 0.6 1.9 2 0 0 2 2 2 1 Mpv17 / PMP22 family TRAPPC-Trs85 PF12739.7 CCM05178.1 - 4.5e-31 108.2 0.0 2.2e-24 86.2 0.0 2.3 2 0 0 2 2 2 2 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_2 PF07719.17 CCM05178.1 - 0.0086 16.1 1.7 3.9 7.8 0.0 3.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TRAPPC9-Trs120 PF08626.11 CCM05178.1 - 0.027 11.8 0.0 0.042 11.2 0.0 1.1 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit WW PF00397.26 CCM05179.1 - 0.0028 17.7 1.3 0.0062 16.6 1.3 1.6 1 0 0 1 1 1 1 WW domain MBD PF01429.19 CCM05179.1 - 0.017 14.8 0.0 2 8.2 0.0 2.5 2 0 0 2 2 2 0 Methyl-CpG binding domain LCCL PF03815.19 CCM05180.1 - 2.5e-15 56.4 0.0 4.4e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 LCCL domain DUF2897 PF11446.8 CCM05180.1 - 6.5 6.7 11.9 0.22 11.4 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) Limkain-b1 PF11608.8 CCM05181.1 - 0.056 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Limkain b1 Seipin PF06775.14 CCM05183.1 - 6.7e-17 62.2 0.0 1.1e-16 61.6 0.0 1.4 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) SH3BGR PF04908.15 CCM05184.1 - 5.7e-06 26.4 0.1 1.7e-05 24.9 0.0 1.7 1 1 1 2 2 2 1 SH3-binding, glutamic acid-rich protein Aldedh PF00171.22 CCM05185.1 - 4.7e-129 430.9 0.1 5.4e-129 430.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CCM05185.1 - 0.018 14.1 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) LMWPc PF01451.21 CCM05186.1 - 3e-23 82.8 0.0 3.4e-23 82.6 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Glyco_hydro_cc PF11790.8 CCM05186.1 - 0.079 12.5 0.0 0.091 12.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core Pox_MCEL PF03291.16 CCM05186.1 - 0.12 11.5 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme DraK_HK_N PF18092.1 CCM05186.1 - 0.14 12.6 0.0 0.56 10.7 0.1 1.8 2 0 0 2 2 2 0 DraK Histidine Kinase N-terminal domain GDI PF00996.18 CCM05188.1 - 1.4e-218 725.7 0.0 1.6e-218 725.5 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Rav1p_C PF12234.8 CCM05189.1 - 1.8e-206 687.4 0.0 2.2e-206 687.1 0.0 1.1 1 0 0 1 1 1 1 RAVE protein 1 C terminal Fasciclin PF02469.22 CCM05190.1 - 1.8e-66 222.1 0.0 1.5e-16 60.8 0.0 5.5 5 1 0 5 5 5 5 Fasciclin domain Mito_carr PF00153.27 CCM05191.1 - 4.3e-61 202.9 4.4 2.8e-19 68.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Not3 PF04065.15 CCM05192.1 - 0.27 10.6 0.3 10 5.5 0.0 2.1 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component NAT PF04768.13 CCM05193.1 - 8.1e-34 116.7 0.0 8.8e-19 67.8 0.0 2.4 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase F-box-like PF12937.7 CCM05194.1 - 1.2e-05 25.0 0.8 2.8e-05 23.9 0.8 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM05194.1 - 0.062 13.2 0.6 0.21 11.5 0.6 1.9 1 0 0 1 1 1 0 F-box domain SbcD_C PF12320.8 CCM05194.1 - 0.18 12.1 0.0 0.33 11.3 0.0 1.4 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain UQ_con PF00179.26 CCM05195.1 - 2.1e-20 72.8 0.0 3.5e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SKN1 PF03935.15 CCM05196.1 - 2.9e-188 626.4 6.2 3.3e-188 626.2 6.2 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) SNAPc_SNAP43 PF09808.9 CCM05197.1 - 0.00029 20.8 0.1 0.00061 19.8 0.1 1.5 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Ima1_N PF09779.9 CCM05198.1 - 3.1e-15 57.2 0.1 5.3e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 Ima1 N-terminal domain Nucleoporin_N PF08801.11 CCM05199.1 - 1.2e-61 208.8 0.0 2e-61 208.1 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 CCM05199.1 - 3.9e-31 108.5 0.0 1.7e-30 106.3 0.0 1.8 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Ribonucleas_3_3 PF14622.6 CCM05200.1 - 4.8e-10 39.7 0.0 8.7e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CCM05200.1 - 1.8e-08 34.9 0.0 5e-08 33.5 0.0 1.8 1 1 0 1 1 1 1 Ribonuclease III domain HORMA PF02301.18 CCM05201.1 - 1e-15 58.0 0.1 2.1e-15 56.9 0.1 1.5 1 1 0 1 1 1 1 HORMA domain ATG101 PF07855.12 CCM05201.1 - 0.0019 18.2 0.2 0.008 16.2 0.2 1.8 1 1 0 1 1 1 1 Autophagy-related protein 101 bacHORMA_2 PF18173.1 CCM05201.1 - 0.091 12.6 0.1 0.18 11.6 0.1 1.6 2 0 0 2 2 2 0 Bacterial HORMA domain 2 NAD_binding_6 PF08030.12 CCM05202.1 - 7.5e-25 87.9 0.0 1.4e-24 87.0 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CCM05202.1 - 1.2e-20 73.6 0.0 2.1e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CCM05202.1 - 4.2e-17 62.4 17.0 8.3e-17 61.5 17.0 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 CCM05202.1 - 0.0078 16.8 0.0 0.14 12.8 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Coatomer_b_Cpla PF14806.6 CCM05202.1 - 0.057 13.4 0.0 0.15 12.0 0.0 1.6 1 1 1 2 2 2 0 Coatomer beta subunit appendage platform TFIID_NTD2 PF04494.15 CCM05203.1 - 5.6e-30 104.2 0.0 9.7e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 CCM05203.1 - 3.2e-28 97.4 4.4 8.4e-07 29.6 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM05203.1 - 3.8e-06 27.1 0.0 0.00079 19.7 0.0 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 CCM05203.1 - 0.0035 17.2 0.1 0.096 12.7 0.0 2.5 2 0 0 2 2 2 1 LisH Cytochrom_D1 PF02239.16 CCM05203.1 - 0.15 10.5 0.0 0.27 9.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain Nup160 PF11715.8 CCM05203.1 - 0.17 10.5 0.1 12 4.4 0.0 2.4 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Amnionless PF14828.6 CCM05205.1 - 0.022 13.6 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Amnionless Syndecan PF01034.20 CCM05205.1 - 0.27 11.2 1.3 0.49 10.3 1.3 1.3 1 0 0 1 1 1 0 Syndecan domain Bacteriocin_IIc PF10439.9 CCM05205.1 - 1.6 8.9 6.7 0.94 9.7 1.1 2.6 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide DUF4342 PF14242.6 CCM05205.1 - 5.9 7.0 4.9 1.7e+02 2.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) FA_desaturase PF00487.24 CCM05206.1 - 9.2e-26 91.2 24.7 1.3e-25 90.7 24.7 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CCM05206.1 - 8.3e-10 38.7 0.0 1.7e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF5485 PF17586.2 CCM05206.1 - 0.024 14.9 0.0 0.056 13.8 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5485) Ribosomal_L13e PF01294.18 CCM05207.1 - 5.3e-74 248.0 4.2 5.3e-74 248.0 4.2 1.3 2 0 0 2 2 2 1 Ribosomal protein L13e Meth_synt_2 PF01717.18 CCM05208.1 - 7.6e-14 51.7 0.0 2.1e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CCM05208.1 - 0.00062 19.4 0.0 0.0069 15.9 0.0 2.1 2 0 0 2 2 2 1 Cobalamin-independent synthase, N-terminal domain PAS_7 PF12860.7 CCM05209.1 - 0.084 13.0 1.4 0.13 12.4 0.7 1.7 2 0 0 2 2 2 0 PAS fold FTA4 PF13093.6 CCM05209.1 - 0.3 11.0 3.3 0.24 11.2 1.0 1.9 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 MnmE_helical PF12631.7 CCM05209.1 - 0.46 10.6 1.8 1.2 9.2 1.8 1.9 1 1 0 1 1 1 0 MnmE helical domain SlyX PF04102.12 CCM05209.1 - 5.8 7.6 7.3 14 6.4 3.1 3.3 2 1 1 3 3 3 0 SlyX DUF2062 PF09835.9 CCM05210.1 - 0.03 14.2 0.1 0.03 14.2 0.1 2.1 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2062) Rossmann-like PF10727.9 CCM05210.1 - 0.053 13.4 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Rossmann-like domain CbtA PF09490.10 CCM05210.1 - 0.18 11.5 6.5 0.96 9.2 6.5 1.9 1 1 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) UbiA PF01040.18 CCM05210.1 - 1.5 8.0 10.6 1.2 8.4 3.2 2.2 2 0 0 2 2 2 0 UbiA prenyltransferase family ER_lumen_recept PF00810.18 CCM05211.1 - 5.3e-54 183.0 10.8 5.3e-54 183.0 10.8 1.8 2 0 0 2 2 2 1 ER lumen protein retaining receptor Lectin_leg-like PF03388.13 CCM05211.1 - 8.9e-33 113.6 0.0 1.3e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family PQ-loop PF04193.14 CCM05211.1 - 1.6 8.6 7.0 1.4 8.7 0.1 3.4 3 0 0 3 3 3 0 PQ loop repeat DnaJ PF00226.31 CCM05212.1 - 1.3e-12 47.6 0.0 2e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Clathrin_lg_ch PF01086.17 CCM05213.1 - 1.5e-46 159.3 0.4 2e-46 158.9 0.4 1.2 1 0 0 1 1 1 1 Clathrin light chain RsbRD_N PF14361.6 CCM05213.1 - 0.029 15.1 3.8 0.047 14.4 3.8 1.3 1 0 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain Endonuc_Holl PF10107.9 CCM05213.1 - 1.4 8.8 5.2 2 8.3 5.2 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase VIR_N PF15912.5 CCM05213.1 - 3.1 7.3 12.4 4.2 6.9 12.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal LRR_8 PF13855.6 CCM05214.1 - 9.3e-13 47.7 14.9 0.00016 21.3 3.1 4.5 2 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 CCM05214.1 - 5.4e-06 26.6 15.1 0.042 14.3 1.3 4.5 1 1 4 5 5 5 3 Leucine Rich repeats (2 copies) LRRNT_2 PF08263.12 CCM05214.1 - 0.0024 18.2 0.6 0.008 16.5 0.6 2.0 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 CCM05214.1 - 0.018 15.0 2.9 0.041 13.8 1.3 2.1 1 1 1 2 2 2 0 BspA type Leucine rich repeat region (6 copies) Calpain_III PF01067.22 CCM05215.1 - 3.6e-17 62.9 0.3 0.0022 18.2 0.0 4.3 4 0 0 4 4 4 4 Calpain large subunit, domain III Peptidase_C2 PF00648.21 CCM05215.1 - 1.5e-08 34.1 0.0 2.4e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 Calpain family cysteine protease MIT PF04212.18 CCM05215.1 - 2.8e-06 27.3 3.5 4.8e-06 26.5 3.5 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Rit1_C PF17184.4 CCM05216.1 - 8.5e-66 222.2 0.0 1.7e-65 221.2 0.0 1.5 1 1 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 CCM05216.1 - 9.1e-28 96.8 0.0 1.8e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain DSPc PF00782.20 CCM05216.1 - 0.098 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Med9 PF07544.13 CCM05217.1 - 0.017 15.2 5.3 0.029 14.5 3.2 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 BLOC1_2 PF10046.9 CCM05217.1 - 0.83 10.0 6.7 5 7.5 0.7 3.8 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 CCM05217.1 - 5.4 7.2 6.7 34 4.6 0.5 3.6 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family DUF4203 PF13886.6 CCM05218.1 - 8.7e-18 64.7 19.5 1.2e-17 64.3 19.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) ABC2_membrane_3 PF12698.7 CCM05218.1 - 9.3 5.2 13.2 16 4.5 13.2 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein FAD_binding_3 PF01494.19 CCM05219.1 - 3.1e-77 260.2 0.0 3.9e-77 259.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM05219.1 - 5.5e-05 22.5 0.5 0.052 12.8 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM05219.1 - 0.00013 21.2 1.4 0.00042 19.5 0.6 1.9 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 CCM05219.1 - 0.00017 21.3 0.5 0.12 11.9 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCM05219.1 - 0.0012 19.0 0.1 0.0041 17.3 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCM05219.1 - 0.0016 19.0 0.0 0.61 10.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM05219.1 - 0.0022 17.3 0.1 0.0046 16.2 0.1 1.5 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CCM05219.1 - 0.0028 16.4 0.2 0.011 14.5 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 CCM05219.1 - 0.012 14.9 0.1 0.021 14.1 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCM05219.1 - 0.014 14.8 0.2 0.046 13.1 0.4 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 CCM05219.1 - 0.11 11.6 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CCM05220.1 - 8e-75 252.3 0.0 1e-74 251.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CCM05220.1 - 1.4e-05 24.4 0.2 0.0016 17.6 0.0 2.8 3 0 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 CCM05220.1 - 0.0016 18.6 0.1 0.0042 17.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CCM05220.1 - 0.0027 16.5 0.1 0.0057 15.4 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 CCM05220.1 - 0.0027 18.2 0.0 0.024 15.2 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM05220.1 - 0.0032 16.7 0.2 0.025 13.8 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM05220.1 - 0.031 13.5 0.1 0.048 12.9 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM05220.1 - 0.042 13.4 0.7 0.23 11.0 0.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 CCM05220.1 - 0.049 12.9 0.0 0.093 11.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 CCM05220.1 - 0.065 12.3 0.1 0.13 11.3 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein ThrE PF06738.12 CCM05223.1 - 6.8e-52 176.2 6.2 6.8e-52 176.2 6.2 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 CCM05223.1 - 7.2e-06 26.2 5.3 7.2e-06 26.2 5.3 2.3 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE EndoU_bacteria PF14436.6 CCM05223.1 - 0.07 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial EndoU nuclease DUF4887 PF16228.5 CCM05223.1 - 0.57 10.3 3.5 1.6 8.9 3.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) Sacchrp_dh_C PF16653.5 CCM05225.1 - 9.5e-87 291.5 0.0 1.5e-86 290.8 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Spermine_synth PF01564.17 CCM05225.1 - 2.2e-67 226.2 0.0 5.5e-67 224.8 0.0 1.7 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 CCM05225.1 - 1e-24 86.2 1.7 1.5e-24 85.6 0.1 2.2 2 0 0 2 2 2 1 Spermidine synthase tetramerisation domain Sacchrp_dh_NADP PF03435.18 CCM05225.1 - 6e-24 84.8 2.3 2e-23 83.1 0.5 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCM05225.1 - 3.3e-08 33.7 0.1 3.1e-07 30.5 0.0 2.3 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Methyltransf_25 PF13649.6 CCM05225.1 - 4.3e-06 27.3 0.1 0.00058 20.5 0.0 3.3 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM05225.1 - 0.0003 21.5 0.0 0.022 15.5 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_10 PF13460.6 CCM05225.1 - 0.0011 19.0 0.4 0.0021 18.0 0.4 1.5 1 0 0 1 1 1 1 NAD(P)H-binding AlaDh_PNT_C PF01262.21 CCM05225.1 - 0.0077 15.5 0.0 0.41 9.9 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 CCM05225.1 - 0.021 15.4 0.1 0.05 14.2 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF1254 PF06863.12 CCM05225.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1254) NAD_binding_3 PF03447.16 CCM05225.1 - 0.07 13.8 0.3 0.13 12.9 0.3 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CCM05225.1 - 0.083 13.3 0.2 16 6.0 0.1 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding MTS PF05175.14 CCM05225.1 - 0.14 11.7 0.0 0.94 9.0 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_18 PF12847.7 CCM05225.1 - 0.16 11.9 0.0 0.39 10.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain GFO_IDH_MocA PF01408.22 CCM05225.1 - 0.28 12.0 0.9 0.48 11.3 0.2 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Prenyltrans PF00432.21 CCM05226.1 - 1.9e-28 97.9 12.6 2.9e-07 30.1 0.3 6.2 5 1 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat F-box-like PF12937.7 CCM05227.1 - 3.6e-08 33.2 3.0 4.4e-08 32.9 0.1 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CCM05227.1 - 0.00022 21.0 0.1 0.00086 19.1 0.1 2.0 1 0 0 1 1 1 1 F-box domain Med21 PF11221.8 CCM05227.1 - 0.22 11.8 0.7 0.4 10.9 0.7 1.3 1 0 0 1 1 1 0 Subunit 21 of Mediator complex F-box-like PF12937.7 CCM05228.1 - 1.9e-08 34.1 0.3 5.3e-07 29.4 0.3 2.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM05228.1 - 0.011 15.6 0.6 0.011 15.6 0.6 2.7 3 0 0 3 3 3 0 F-box domain LRR_4 PF12799.7 CCM05228.1 - 0.52 10.8 18.1 8.3 7.0 0.0 7.5 7 3 1 8 8 8 0 Leucine Rich repeats (2 copies) ADH_N PF08240.12 CCM05229.1 - 9.6e-19 67.3 0.3 1.7e-18 66.5 0.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM05229.1 - 1.9e-14 53.8 0.0 3.1e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CCM05229.1 - 0.06 12.6 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FMO-like PF00743.19 CCM05231.1 - 1e-19 70.4 0.0 1.2e-16 60.3 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCM05231.1 - 2e-17 63.4 0.0 1.9e-14 53.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM05231.1 - 3.2e-17 62.7 0.2 1.1e-06 28.2 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM05231.1 - 1.4e-10 40.8 0.2 9.3e-08 31.6 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CCM05231.1 - 3.1e-05 24.1 0.1 0.00014 22.0 0.1 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCM05231.1 - 4.3e-05 23.6 0.0 0.045 13.7 0.0 2.7 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CCM05231.1 - 6.5e-05 22.3 0.1 0.0003 20.2 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CCM05231.1 - 0.00081 19.9 0.5 0.02 15.5 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CCM05231.1 - 0.00098 19.2 0.7 0.066 13.3 0.1 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 CCM05231.1 - 0.0018 17.0 3.6 0.0026 16.5 0.1 2.4 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CCM05231.1 - 0.0019 17.8 0.2 0.056 13.0 0.0 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM05231.1 - 0.0032 16.6 0.6 0.035 13.1 0.0 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 CCM05231.1 - 0.0035 16.7 0.0 2.4 7.5 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 CCM05231.1 - 0.0039 16.3 6.8 0.18 10.9 0.0 2.7 3 1 0 3 3 3 2 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CCM05231.1 - 0.013 14.8 1.4 0.12 11.6 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 CCM05231.1 - 0.017 15.6 0.0 2.7 8.5 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 CCM05231.1 - 0.022 13.9 1.5 0.049 12.7 1.5 1.6 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 CCM05231.1 - 0.067 12.5 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase RbsD_FucU PF05025.13 CCM05231.1 - 0.11 13.0 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 RbsD / FucU transport protein family Thi4 PF01946.17 CCM05231.1 - 0.15 11.3 0.6 0.48 9.6 0.0 2.0 2 0 0 2 2 2 0 Thi4 family adh_short PF00106.25 CCM05231.1 - 0.15 11.5 0.5 16 4.9 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase ABM PF03992.16 CCM05232.1 - 4.2e-10 39.6 0.2 5e-10 39.3 0.2 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Cas_Cas5d PF09704.10 CCM05232.1 - 0.1 12.4 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas5) DUF3446 PF11928.8 CCM05233.1 - 0.0044 17.3 0.4 0.0044 17.3 0.4 3.6 4 0 0 4 4 4 1 Early growth response N-terminal domain Sugar_tr PF00083.24 CCM05234.1 - 5.7e-100 335.3 26.3 6.9e-100 335.0 26.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM05234.1 - 8.1e-24 84.2 29.6 1.2e-22 80.3 25.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DNA_binding_1 PF01035.20 CCM05235.1 - 2.3e-13 50.1 0.0 3.5e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain HET PF06985.11 CCM05236.1 - 3.6e-15 56.6 0.5 2e-12 47.7 0.0 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) G-alpha PF00503.20 CCM05237.1 - 9.5e-104 347.3 0.0 1.1e-103 347.1 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCM05237.1 - 2.7e-13 49.7 0.0 5.6e-09 35.7 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 CCM05237.1 - 0.013 15.7 0.0 2.1 8.6 0.0 2.9 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCM05237.1 - 0.015 15.1 0.0 0.05 13.4 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 CCM05237.1 - 0.029 13.7 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.6 CCM05237.1 - 0.03 14.0 0.0 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCM05237.1 - 0.051 13.9 0.0 3.7 7.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCM05237.1 - 0.058 12.5 0.0 0.093 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) FmdA_AmdA PF03069.15 CCM05238.1 - 6.1e-63 212.9 0.0 2.1e-38 132.2 0.1 2.0 1 1 1 2 2 2 2 Acetamidase/Formamidase family PCNA_N PF00705.18 CCM05240.1 - 1.4e-51 173.4 3.3 3.1e-51 172.4 3.3 1.5 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 CCM05240.1 - 2e-42 144.4 0.3 9.3e-20 71.1 0.0 2.7 3 0 0 3 3 3 2 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 CCM05240.1 - 1.3e-06 28.1 0.0 1.1e-05 25.0 0.0 2.2 2 1 0 2 2 2 1 Rad9 CDC45 PF02724.14 CCM05240.1 - 0.016 13.5 18.6 0.025 12.9 18.6 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF3246 PF11596.8 CCM05240.1 - 0.026 14.0 5.0 0.039 13.4 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) BUD22 PF09073.10 CCM05240.1 - 0.24 10.7 31.9 0.33 10.3 31.9 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CCM05240.1 - 0.25 9.5 29.3 0.37 9.0 29.3 1.2 1 0 0 1 1 1 0 Nop14-like family Raftlin PF15250.6 CCM05240.1 - 0.54 8.9 12.3 0.73 8.5 12.3 1.1 1 0 0 1 1 1 0 Raftlin Herpes_LMP1 PF05297.11 CCM05240.1 - 1.1 8.3 6.9 1.6 7.9 6.9 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Hus1 PF04005.12 CCM05240.1 - 1.6 7.7 6.4 6.4 5.8 0.0 3.4 3 1 1 4 4 4 0 Hus1-like protein SAPS PF04499.15 CCM05240.1 - 2.3 6.9 10.6 3.1 6.5 10.6 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SDA1 PF05285.12 CCM05240.1 - 3.8 6.8 36.8 5.4 6.3 36.8 1.1 1 0 0 1 1 1 0 SDA1 TatD_DNase PF01026.21 CCM05242.1 - 3.1e-43 148.0 0.0 3.9e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase p450 PF00067.22 CCM05245.1 - 3.4e-66 223.9 0.0 1.5e-63 215.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 GMC_oxred_N PF00732.19 CCM05247.1 - 1.4e-42 146.1 0.0 8.3e-41 140.3 0.0 2.2 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05247.1 - 2.9e-27 96.0 0.0 5.3e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCM05247.1 - 0.0005 20.2 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCM05247.1 - 0.0014 17.9 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CCM05247.1 - 0.0018 18.0 0.0 0.0045 16.6 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM05247.1 - 0.0019 17.4 0.1 0.0028 16.8 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCM05247.1 - 0.0021 17.2 0.1 0.01 14.9 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM05247.1 - 0.041 13.1 0.0 0.092 12.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM05247.1 - 0.11 11.2 0.1 0.58 8.8 0.1 1.9 2 0 0 2 2 2 0 HI0933-like protein TrkA_N PF02254.18 CCM05247.1 - 0.16 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain RNaseH_pPIWI_RE PF13032.6 CCM05248.1 - 0.74 9.7 2.5 1.1 9.1 2.5 1.1 1 0 0 1 1 1 0 RNaseH domain of pPIWI_RE MFS_1 PF07690.16 CCM05249.1 - 9.7e-07 28.0 9.7 8.7e-06 24.9 9.7 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily GMC_oxred_N PF00732.19 CCM05250.1 - 1.9e-54 185.1 0.0 2.5e-54 184.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05250.1 - 6.1e-31 107.9 0.0 1.1e-30 107.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CCM05250.1 - 1.4e-05 24.8 0.4 3.2e-05 23.7 0.4 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM05250.1 - 0.00021 20.5 3.2 0.0021 17.2 3.2 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CCM05250.1 - 0.0016 18.6 0.1 0.0042 17.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CCM05250.1 - 0.0016 17.5 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 CCM05250.1 - 0.0027 17.0 0.5 0.0051 16.1 0.2 1.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 CCM05250.1 - 0.0039 16.5 0.0 0.31 10.2 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM05250.1 - 0.019 13.7 0.1 0.68 8.6 0.2 2.1 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 CCM05250.1 - 0.049 12.9 0.2 0.54 9.4 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_3 PF07859.13 CCM05251.1 - 2.9e-24 86.1 0.0 3.9e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCM05251.1 - 2.8e-11 42.9 0.0 6.1e-11 41.8 0.0 1.4 2 0 0 2 2 2 1 Steryl acetyl hydrolase DUF5122 PF17164.4 CCM05251.1 - 0.011 16.0 0.7 0.031 14.6 0.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5122) beta-propeller TPPK_C PF12555.8 CCM05252.1 - 0.062 13.3 3.4 0.36 10.9 0.2 2.9 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal DUF2510 PF10708.9 CCM05252.1 - 0.28 11.0 1.2 3.1 7.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) ketoacyl-synt PF00109.26 CCM05253.1 - 1.3e-56 192.0 0.2 1.4e-55 188.6 0.0 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CCM05253.1 - 1.2e-36 126.8 0.0 2.2e-36 126.0 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CCM05253.1 - 3.4e-35 121.6 0.2 2.4e-31 109.0 0.0 2.6 2 0 0 2 2 2 2 KR domain NAD_binding_4 PF07993.12 CCM05253.1 - 2.3e-33 115.5 0.0 3.3e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 CCM05253.1 - 1.5e-28 99.2 0.0 5.8e-28 97.3 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCM05253.1 - 2.5e-27 95.9 0.0 5.8e-27 94.7 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CCM05253.1 - 8.7e-11 42.3 0.0 1.8e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Epimerase PF01370.21 CCM05253.1 - 8.8e-11 41.7 0.0 1.7e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CCM05253.1 - 1.8e-05 25.0 0.7 5.5e-05 23.5 0.7 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CCM05253.1 - 0.00031 20.2 0.0 0.0033 16.9 0.0 2.6 2 0 0 2 2 2 1 short chain dehydrogenase Thiolase_N PF00108.23 CCM05253.1 - 0.0035 16.8 0.1 0.0066 15.8 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 CCM05253.1 - 0.096 11.8 0.2 0.29 10.2 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein ACP_syn_III PF08545.10 CCM05253.1 - 0.16 11.8 0.4 0.66 9.9 0.0 2.2 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 3Beta_HSD PF01073.19 CCM05253.1 - 0.2 10.6 0.0 0.39 9.7 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family BRI3BP PF14965.6 CCM05255.1 - 0.014 14.9 1.0 0.014 14.9 1.0 3.2 3 0 0 3 3 3 0 Negative regulator of p53/TP53 Semialdhyde_dh PF01118.24 CCM05256.1 - 0.0061 17.0 0.0 0.0082 16.6 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CCM05256.1 - 0.036 13.5 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM05256.1 - 0.062 13.2 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding FIBP PF05427.11 CCM05257.1 - 0.031 13.6 0.5 0.035 13.4 0.5 1.1 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) DUF5126 PF17166.4 CCM05257.1 - 0.11 12.4 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5126) p450 PF00067.22 CCM05258.1 - 8.7e-67 225.8 0.0 1.6e-66 225.0 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 LodA_N PF17990.1 CCM05259.1 - 2.6e-40 138.7 0.1 4.7e-38 131.3 0.1 2.2 1 1 0 1 1 1 1 L-Lysine epsilon oxidase N-terminal LodA_C PF18417.1 CCM05259.1 - 2.2e-26 92.4 0.1 9e-26 90.4 0.1 1.9 1 1 0 1 1 1 1 L-lysine epsilon oxidase C-terminal domain Ferritin-like PF12902.7 CCM05260.1 - 8.2e-37 127.2 0.0 1.1e-36 126.8 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like Trp_halogenase PF04820.14 CCM05261.1 - 1.9e-17 63.3 0.9 2.6e-11 43.0 0.2 2.4 2 1 0 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 CCM05261.1 - 5.8e-07 29.1 1.8 0.013 14.8 0.0 2.8 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 CCM05261.1 - 1.2e-05 25.1 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM05261.1 - 8.2e-05 21.8 1.2 0.00079 18.6 0.6 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_oxidored PF12831.7 CCM05261.1 - 8.4e-05 22.1 0.1 0.0002 20.8 0.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM05261.1 - 9.5e-05 21.6 0.8 0.00015 21.0 0.8 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM05261.1 - 0.00016 21.0 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM05261.1 - 0.0025 18.0 0.2 0.0068 16.6 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CCM05261.1 - 0.0026 16.9 0.4 0.0045 16.1 0.4 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 CCM05261.1 - 0.004 15.9 0.1 0.0055 15.4 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 CCM05261.1 - 0.009 15.3 0.1 0.036 13.3 0.1 2.0 3 0 0 3 3 3 1 Thi4 family AlaDh_PNT_C PF01262.21 CCM05261.1 - 0.087 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CCM05263.1 - 1.8e-19 70.1 0.2 4.3e-17 62.3 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCM05263.1 - 1.9e-16 59.6 0.0 5.4e-16 58.1 0.0 1.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCM05263.1 - 4.3e-13 49.2 0.0 7.4e-09 35.2 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM05263.1 - 1.4e-12 47.5 0.3 8.8e-10 38.2 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CCM05263.1 - 0.00097 18.3 0.1 0.023 13.7 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 CCM05263.1 - 0.0016 18.5 0.0 0.38 10.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CCM05263.1 - 0.0017 18.5 0.4 0.0096 16.1 0.0 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 CCM05263.1 - 0.002 18.4 0.2 0.062 13.6 0.0 2.9 3 0 0 3 3 3 1 TrkA-N domain GIDA PF01134.22 CCM05263.1 - 0.0022 17.2 0.3 0.12 11.4 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CCM05263.1 - 0.0026 17.1 0.1 0.0082 15.4 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CCM05263.1 - 0.0033 16.2 0.2 0.0066 15.2 0.1 1.6 2 0 0 2 2 2 1 HI0933-like protein Shikimate_DH PF01488.20 CCM05263.1 - 0.0034 17.4 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 CCM05263.1 - 0.0083 15.2 0.2 0.019 14.1 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CCM05263.1 - 0.01 16.4 0.2 1.9 9.1 0.0 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM05263.1 - 0.014 15.0 0.3 0.28 10.7 0.0 2.8 2 1 0 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.17 CCM05263.1 - 0.033 13.4 0.0 0.088 12.0 0.0 1.6 1 0 0 1 1 1 0 Thi4 family 2-Hacid_dh_C PF02826.19 CCM05263.1 - 0.1 11.9 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCM05263.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GMC_oxred_N PF00732.19 CCM05264.1 - 4.7e-57 193.6 0.0 5.9e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05264.1 - 9.9e-35 120.2 0.1 1.8e-34 119.3 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCM05264.1 - 1.7e-05 24.1 0.2 0.14 11.2 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CCM05264.1 - 2.4e-05 23.6 0.1 4.1e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCM05264.1 - 4.6e-05 23.6 0.0 0.00059 20.0 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCM05264.1 - 5.2e-05 22.6 0.1 0.0037 16.6 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 CCM05264.1 - 0.00012 21.5 0.0 0.00034 20.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM05264.1 - 0.00086 18.7 0.5 0.56 9.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CCM05264.1 - 0.0028 17.0 0.0 0.005 16.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CCM05264.1 - 0.015 14.9 0.4 0.037 13.6 0.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Mustang PF15682.5 CCM05264.1 - 0.02 15.0 0.1 0.064 13.3 0.1 1.8 1 0 0 1 1 1 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 HI0933_like PF03486.14 CCM05264.1 - 0.021 13.6 0.1 0.033 12.9 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein WD40 PF00400.32 CCM05265.1 - 2.2e-116 376.4 58.7 2.9e-08 34.2 0.5 15.0 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM05265.1 - 3.6e-28 97.7 19.6 0.24 11.7 0.1 13.7 2 2 10 14 14 14 10 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCM05265.1 - 2.1e-14 53.5 10.6 2.6 8.6 0.1 12.5 13 1 1 14 14 14 1 PQQ-like domain WD40_like PF17005.5 CCM05265.1 - 2.6e-13 50.0 0.1 0.0061 15.9 0.0 7.3 8 0 0 8 8 8 3 WD40-like domain Nup160 PF11715.8 CCM05265.1 - 1e-09 37.6 12.4 0.19 10.3 0.0 9.5 9 3 1 11 11 11 3 Nucleoporin Nup120/160 FeThRed_A PF02941.15 CCM05265.1 - 2e-09 37.4 9.8 8.1 6.7 0.0 10.0 8 3 3 11 11 11 1 Ferredoxin thioredoxin reductase variable alpha chain PD40 PF07676.12 CCM05265.1 - 5.7e-08 32.5 0.0 42 4.2 0.0 10.1 13 0 0 13 13 12 0 WD40-like Beta Propeller Repeat AAA_16 PF13191.6 CCM05265.1 - 8.1e-08 32.8 0.0 2e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Ge1_WD40 PF16529.5 CCM05265.1 - 2.5e-07 30.0 1.2 1.9 7.4 0.0 8.0 2 2 7 10 10 10 1 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 CCM05265.1 - 8.6e-07 29.0 0.0 2.5e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain DUF727 PF05303.12 CCM05265.1 - 1.7e-06 28.0 4.1 16 5.6 0.0 8.3 7 4 4 11 11 10 0 Protein of unknown function (DUF727) PQQ_2 PF13360.6 CCM05265.1 - 5.4e-06 26.2 15.1 1.1 8.8 0.5 5.9 1 1 4 5 5 5 3 PQQ-like domain PQQ PF01011.21 CCM05265.1 - 9.9e-06 25.2 0.0 27 4.9 0.0 7.5 11 0 0 11 11 11 0 PQQ enzyme repeat Nucleoporin_N PF08801.11 CCM05265.1 - 3.9e-05 22.6 12.8 1.1 8.0 0.2 6.8 2 2 3 7 7 7 3 Nup133 N terminal like Peptidase_S9_N PF02897.15 CCM05265.1 - 0.0014 17.5 1.1 22 3.7 0.0 5.6 4 4 2 6 6 6 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Cytochrom_D1 PF02239.16 CCM05265.1 - 0.0086 14.6 14.3 0.084 11.4 0.4 5.0 4 1 1 5 5 5 2 Cytochrome D1 heme domain DUF5570 PF17731.1 CCM05265.1 - 0.22 11.6 10.9 0.46 10.6 0.1 5.6 4 3 2 7 7 7 0 Family of unknown function (DUF5570) CHAP PF05257.16 CCM05265.1 - 0.33 11.6 24.3 2.8 8.6 0.2 8.3 2 2 3 8 8 8 0 CHAP domain SUKH-4 PF14435.6 CCM05265.1 - 1.4 8.9 4.9 55 3.8 0.0 4.4 6 0 0 6 6 5 0 SUKH-4 immunity protein MFS_1 PF07690.16 CCM05266.1 - 2.2e-20 72.9 18.9 3.3e-20 72.3 18.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Transgly_assoc PF04226.13 CCM05266.1 - 0.09 13.0 1.0 0.65 10.3 1.0 2.5 1 0 0 1 1 1 0 Transglycosylase associated protein WSC PF01822.19 CCM05267.1 - 4.5e-27 94.1 18.7 6.4e-15 55.1 8.2 2.1 2 0 0 2 2 2 2 WSC domain PAN_3 PF08277.12 CCM05267.1 - 6.2 6.7 8.5 1.2 9.0 1.5 2.4 2 0 0 2 2 2 0 PAN-like domain Toxin_35 PF10530.9 CCM05267.1 - 7.5 6.6 9.6 1.6 8.8 0.4 2.5 2 0 0 2 2 2 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold FlaC_arch PF05377.11 CCM05268.1 - 0.021 15.2 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Lebercilin PF15619.6 CCM05268.1 - 0.074 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF3294 PF07957.11 CCM05268.1 - 0.13 12.0 0.1 1.2 8.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3294) DUF4140 PF13600.6 CCM05268.1 - 0.29 11.6 4.5 1.2 9.7 2.2 2.7 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ABC_tran_CTD PF16326.5 CCM05268.1 - 0.36 11.1 3.3 0.27 11.5 0.8 2.1 2 1 0 2 2 2 0 ABC transporter C-terminal domain ERG4_ERG24 PF01222.17 CCM05269.1 - 2.4e-06 26.6 0.0 3.3e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ICMT PF04140.14 CCM05269.1 - 0.00076 19.8 0.1 0.0027 18.1 0.0 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM05269.1 - 0.077 13.4 0.2 0.93 9.9 0.0 2.3 2 0 0 2 2 2 0 Phospholipid methyltransferase O_anti_polymase PF01901.16 CCM05271.1 - 0.21 10.8 0.5 0.33 10.2 0.5 1.3 1 0 0 1 1 1 0 Putative O-antigen polymerase WD40 PF00400.32 CCM05272.1 - 8.6e-61 200.5 13.0 8.5e-08 32.8 0.0 8.5 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM05272.1 - 1.6e-25 89.2 0.0 0.0012 19.0 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCM05272.1 - 1.4e-10 41.3 0.0 0.0032 17.4 0.0 3.6 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCM05272.1 - 4.7e-09 35.7 0.4 1.5 7.7 0.0 5.8 3 2 3 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CCM05272.1 - 8.4e-06 25.3 0.0 1.2 8.4 0.0 3.6 4 0 0 4 4 4 2 WD40-like domain PD40 PF07676.12 CCM05272.1 - 0.00033 20.5 7.9 26 4.9 0.0 6.4 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCM05272.1 - 0.0011 17.6 0.1 0.9 8.0 0.0 3.6 2 1 2 4 4 4 2 Cytochrome D1 heme domain Nup160 PF11715.8 CCM05272.1 - 0.0026 16.5 0.5 0.39 9.3 0.0 3.3 1 1 1 3 3 3 1 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 CCM05272.1 - 0.019 14.7 3.4 51 3.7 0.0 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Nbas_N PF15492.6 CCM05272.1 - 0.031 13.6 1.2 13 5.0 0.0 3.8 2 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 CCM05272.1 - 0.063 12.2 0.1 13 4.6 0.0 3.4 1 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain TruB_C PF09142.11 CCM05272.1 - 0.077 12.8 5.9 0.57 10.0 0.1 3.7 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal DUF3748 PF12566.8 CCM05272.1 - 0.11 12.4 0.0 3.4 7.7 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3748) Ras PF00071.22 CCM05273.1 - 3.6e-14 52.7 0.1 7e-09 35.5 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 CCM05273.1 - 0.0018 18.5 0.0 0.0024 18.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Tox-PL-2 PF15643.6 CCM05273.1 - 0.037 14.1 0.0 0.053 13.6 0.0 1.1 1 0 0 1 1 1 0 Papain fold toxin 2 Cys_Met_Meta_PP PF01053.20 CCM05275.1 - 5.7e-129 430.0 0.0 7.4e-129 429.6 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CCM05275.1 - 8.4e-10 38.1 0.0 1.3e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CCM05275.1 - 8.9e-09 35.0 0.0 1.3e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCM05275.1 - 1.2e-07 31.4 0.0 2.1e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CCM05275.1 - 0.17 11.2 0.0 7.6 5.7 0.0 2.3 2 1 0 2 2 2 0 Beta-eliminating lyase Asparaginase_C PF17763.1 CCM05275.1 - 0.17 12.1 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain HET PF06985.11 CCM05276.1 - 1.1e-10 42.0 3.0 1.1e-06 29.1 0.1 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Peptidase_S9 PF00326.21 CCM05277.1 - 5.7e-36 124.0 0.0 1e-35 123.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CCM05277.1 - 9.8e-05 21.7 0.1 0.00043 19.6 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 AXE1 PF05448.12 CCM05277.1 - 0.0013 17.5 0.1 0.026 13.2 0.0 2.2 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 CCM05277.1 - 0.0045 16.6 0.2 0.042 13.4 0.2 2.2 1 1 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 CCM05277.1 - 0.074 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 CCM05277.1 - 0.15 12.2 0.0 0.55 10.4 0.0 1.9 2 0 0 2 2 2 0 TAP-like protein MFS_1 PF07690.16 CCM05278.1 - 5.3e-29 101.2 47.7 1.3e-27 96.7 28.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C2H2_jaz PF12171.8 CCM05279.1 - 5.7e-10 39.2 14.2 4.6e-07 29.9 0.0 4.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CCM05279.1 - 6.7e-06 26.5 33.9 0.19 12.7 0.1 6.4 6 0 0 6 6 6 3 C2H2-type zinc finger zf-met PF12874.7 CCM05279.1 - 0.001 19.4 0.2 0.001 19.4 0.2 4.0 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CCM05279.1 - 0.014 15.4 1.1 0.014 15.4 1.1 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCM05279.1 - 0.044 14.1 0.6 0.044 14.1 0.6 4.1 3 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCM05279.1 - 0.13 12.7 0.1 0.13 12.7 0.1 6.2 7 0 0 7 7 7 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM05279.1 - 0.2 12.2 19.1 15 6.2 1.7 5.5 5 0 0 5 5 5 0 Zinc-finger double domain zf_ZIC PF18366.1 CCM05279.1 - 0.25 11.5 6.4 18 5.6 0.0 3.8 4 0 0 4 4 4 0 Zic proteins zinc finger domain AKAP95 PF04988.12 CCM05279.1 - 0.27 11.5 3.8 5 7.3 0.1 2.8 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.26 CCM05280.1 - 6.8e-06 26.3 5.2 0.027 14.9 0.2 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM05280.1 - 4e-05 24.1 2.6 0.3 12.1 0.3 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCM05280.1 - 0.0019 18.5 0.7 0.017 15.5 0.2 2.0 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 CCM05280.1 - 0.0073 16.3 0.4 0.0073 16.3 0.4 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 CCM05280.1 - 0.034 14.5 0.3 0.078 13.4 0.3 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCM05280.1 - 0.042 14.1 0.3 0.078 13.3 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CCM05281.1 - 0.0013 19.0 9.8 0.055 14.0 1.5 3.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM05281.1 - 0.0027 18.4 5.3 0.56 11.2 0.9 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCM05281.1 - 0.0088 16.0 1.5 0.016 15.2 1.5 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCM05281.1 - 0.014 15.7 2.8 0.042 14.2 0.7 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CCM05282.1 - 7.6e-09 35.6 4.2 0.00045 20.4 2.0 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CCM05282.1 - 2.1e-08 34.3 12.9 0.14 13.1 0.4 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 CCM05282.1 - 8.5e-08 32.3 7.3 0.0014 19.0 1.0 3.6 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CCM05282.1 - 2.6e-07 30.5 18.8 0.0061 16.5 0.4 5.4 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2 PF00096.26 CCM05282.1 - 6.2e-07 29.5 15.4 0.36 11.4 0.2 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CCM05282.1 - 8.8e-05 22.8 3.9 0.081 13.3 0.1 3.2 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 CCM05282.1 - 0.00015 22.1 4.6 0.14 12.7 0.1 4.0 4 0 0 4 4 4 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_8 PF15909.5 CCM05282.1 - 0.0067 16.7 1.1 1.2 9.4 0.2 2.7 2 0 0 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 CCM05282.1 - 0.18 11.6 6.3 1.3 8.9 0.4 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type Pkinase PF00069.25 CCM05283.1 - 7.3e-34 117.3 0.0 1.7e-15 57.2 0.0 3.2 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05283.1 - 4.8e-05 22.8 0.0 0.26 10.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase GTPase_binding PF09027.10 CCM05283.1 - 0.029 14.4 0.1 5.1 7.1 0.0 2.7 2 0 0 2 2 2 0 GTPase binding Tyr-DNA_phospho PF06087.12 CCM05286.1 - 3.6e-59 200.8 0.0 7.1e-59 199.8 0.0 1.4 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase EMC1_C PF07774.13 CCM05286.1 - 1.7e-53 181.5 0.0 3.2e-53 180.6 0.0 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 CCM05286.1 - 1.1e-11 44.8 2.6 4.1e-06 26.6 0.1 3.7 3 1 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 CCM05286.1 - 3.2e-06 26.8 5.9 0.038 13.9 0.0 4.9 5 0 0 5 5 5 2 PQQ enzyme repeat PLDc_2 PF13091.6 CCM05286.1 - 0.1 12.5 0.1 2.7 7.9 0.1 3.0 2 1 0 2 2 2 0 PLD-like domain UIM PF02809.20 CCM05286.1 - 0.21 11.6 13.5 0.38 10.8 1.6 3.3 3 0 0 3 3 3 0 Ubiquitin interaction motif His_Phos_2 PF00328.22 CCM05287.1 - 1.8e-10 40.7 0.8 0.00031 20.2 1.1 2.7 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) RNB PF00773.19 CCM05288.1 - 4.2e-62 210.4 0.0 5.2e-62 210.1 0.0 1.0 1 0 0 1 1 1 1 RNB domain SLAIN PF15301.6 CCM05289.1 - 0.036 13.3 0.7 0.041 13.2 0.7 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family Viral_helicase1 PF01443.18 CCM05289.1 - 0.046 13.5 0.0 0.057 13.2 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF3382 PF11862.8 CCM05290.1 - 0.011 16.0 0.9 0.025 14.9 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3382) Sin3_corepress PF08295.12 CCM05291.1 - 0.01 15.9 0.0 0.028 14.5 0.0 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor ZapB PF06005.12 CCM05291.1 - 0.086 13.3 2.7 0.81 10.2 0.1 2.8 2 1 1 3 3 3 0 Cell division protein ZapB HMG_box_2 PF09011.10 CCM05292.1 - 8.5e-15 55.1 2.0 7.2e-06 26.5 1.3 2.7 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.19 CCM05292.1 - 1.9e-14 53.8 6.2 8.9e-07 29.2 1.7 3.0 2 1 0 2 2 2 2 HMG (high mobility group) box Catalase-rel PF06628.12 CCM05292.1 - 0.048 13.9 0.8 22 5.4 0.1 3.1 2 1 0 2 2 2 0 Catalase-related immune-responsive HDV_ag PF01517.18 CCM05292.1 - 0.1 12.4 1.6 0.16 11.7 1.6 1.4 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen DUF1289 PF06945.13 CCM05292.1 - 0.18 11.7 1.0 19 5.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) DUF3106 PF11304.8 CCM05292.1 - 0.18 12.3 6.6 0.67 10.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3106) RGS PF00615.19 CCM05293.1 - 1.8e-09 37.9 0.8 0.00034 20.9 0.1 2.6 2 1 0 2 2 2 2 Regulator of G protein signaling domain Solute_trans_a PF03619.16 CCM05294.1 - 1.3e-92 310.0 11.0 1.6e-92 309.8 11.0 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Pex19 PF04614.12 CCM05295.1 - 1.3e-62 211.7 5.5 1.3e-62 211.7 5.5 1.7 2 0 0 2 2 2 1 Pex19 protein family UCH PF00443.29 CCM05295.1 - 0.077 12.5 0.0 0.16 11.5 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Mito_carr PF00153.27 CCM05296.1 - 1.5e-51 172.3 0.6 3.7e-16 58.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein RNase_P_p30 PF01876.16 CCM05297.1 - 1.4e-36 126.0 0.0 1.9e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Fungal_trans PF04082.18 CCM05299.1 - 2e-23 82.8 0.0 3.2e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM05299.1 - 4.6e-10 39.5 11.5 9.8e-10 38.4 11.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Asp PF00026.23 CCM05300.1 - 3.9e-28 98.8 0.0 7e-14 52.0 0.1 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM05300.1 - 3.6e-05 24.1 0.3 0.23 11.7 0.1 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal PhoLip_ATPase_C PF16212.5 CCM05301.1 - 4e-74 249.5 30.5 4e-74 249.5 30.5 1.8 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCM05301.1 - 4.7e-21 74.2 0.1 4.7e-21 74.2 0.1 2.2 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CCM05301.1 - 3.1e-12 46.4 0.0 6.7e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CCM05301.1 - 1.2e-11 45.4 2.1 3.4e-05 24.2 0.5 3.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCM05301.1 - 7e-09 35.5 3.2 4.2e-07 29.7 0.0 3.1 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CCM05301.1 - 0.00038 20.3 0.0 0.014 15.2 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CCM05301.1 - 0.013 15.9 0.0 1.3 9.4 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SGL PF08450.12 CCM05302.1 - 6.1e-33 114.4 0.0 1.7e-32 113.0 0.0 1.7 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 CCM05302.1 - 4.6e-05 23.5 0.0 0.00037 20.6 0.0 2.6 2 1 0 2 2 2 1 Strictosidine synthase Arylesterase PF01731.20 CCM05302.1 - 0.00067 19.8 0.0 0.012 15.8 0.0 2.4 1 1 1 2 2 2 1 Arylesterase PD40 PF07676.12 CCM05302.1 - 0.0009 19.1 2.8 0.32 11.0 0.1 2.8 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat F-box-like PF12937.7 CCM05303.1 - 2.8e-09 36.7 0.0 7.1e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 F-box-like CDKN3 PF05706.12 CCM05304.1 - 4.5e-05 23.2 0.2 6.3e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 CCM05304.1 - 6.2e-05 22.8 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CCM05304.1 - 0.00033 20.7 0.1 0.00063 19.8 0.1 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CCM05304.1 - 0.0083 16.3 0.0 0.021 15.0 0.0 1.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 CCM05304.1 - 0.0084 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhv PF00073.20 CCM05305.1 - 0.083 12.5 0.0 0.18 11.4 0.0 1.5 1 1 0 1 1 1 0 picornavirus capsid protein Pkinase PF00069.25 CCM05307.1 - 5.4e-61 206.3 0.0 6.7e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05307.1 - 2.5e-26 92.5 0.0 3.1e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM05307.1 - 7.1e-06 25.5 0.0 2.3e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CCM05307.1 - 0.0092 15.9 0.1 0.024 14.5 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCM05307.1 - 0.012 14.6 0.0 0.05 12.5 0.0 1.9 2 1 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 CCM05307.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_C14 PF00656.22 CCM05308.1 - 3e-57 194.4 0.1 3.9e-57 194.1 0.1 1.1 1 0 0 1 1 1 1 Caspase domain AAA_13 PF13166.6 CCM05310.1 - 1.8 7.1 9.0 2.4 6.7 9.0 1.1 1 0 0 1 1 1 0 AAA domain PBP PF01161.20 CCM05312.1 - 4.9e-15 56.0 0.0 5.8e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Pkinase PF00069.25 CCM05314.1 - 1.2e-59 201.8 0.0 1.4e-30 106.6 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain HGTP_anticodon2 PF12745.7 CCM05314.1 - 2.1e-45 155.3 3.9 2.8e-45 154.9 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase_Tyr PF07714.17 CCM05314.1 - 6.4e-30 104.3 0.0 2.5e-14 53.2 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 CCM05314.1 - 2.8e-14 53.4 0.0 6.9e-14 52.1 0.0 1.7 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.6 CCM05314.1 - 1.8e-11 43.9 0.1 5.3e-11 42.3 0.0 1.8 2 1 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.23 CCM05314.1 - 0.00015 21.8 1.0 0.00098 19.1 0.0 2.7 3 0 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM05314.1 - 0.0042 15.9 0.0 0.0096 14.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 CCM05314.1 - 0.049 13.2 0.0 7.1 6.2 0.0 2.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 CCM05314.1 - 0.05 12.9 0.0 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF1682 PF07946.14 CCM05314.1 - 7.4 5.7 8.9 12 5.0 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Methyltransf_16 PF10294.9 CCM05316.1 - 3.4e-16 59.5 0.0 2.7e-15 56.5 0.0 2.0 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 CCM05316.1 - 2.3e-05 25.0 0.0 0.00025 21.7 0.0 2.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM05316.1 - 0.00037 21.2 0.0 0.0014 19.3 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM05316.1 - 0.0018 18.1 0.0 0.0036 17.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CCM05316.1 - 0.0092 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 CCM05316.1 - 0.097 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CCM05316.1 - 0.11 12.0 0.1 0.34 10.4 0.1 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Ribosomal_L7Ae PF01248.26 CCM05318.1 - 5.6e-22 77.3 0.5 1e-21 76.5 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Cupin_8 PF13621.6 CCM05320.1 - 1.6e-19 70.6 0.1 2.4e-19 70.1 0.1 1.3 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 CCM05320.1 - 9.2e-19 68.0 0.2 1.5e-18 67.2 0.2 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase 4HBT PF03061.22 CCM05321.1 - 7.9e-09 35.8 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily ERCC4 PF02732.15 CCM05322.1 - 2.4e-21 76.6 0.0 4.4e-21 75.7 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain FTCD_C PF04961.12 CCM05322.1 - 0.075 12.8 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DUF1841 PF08897.11 CCM05322.1 - 0.11 12.6 0.2 0.22 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1841) Acyltransferase PF01553.21 CCM05324.1 - 8.7e-09 35.1 0.0 5.9e-08 32.4 0.0 2.2 2 0 0 2 2 2 1 Acyltransferase F-box-like PF12937.7 CCM05325.1 - 0.016 15.1 0.4 0.047 13.6 0.4 1.8 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 CCM05325.1 - 0.063 13.2 0.0 2.3 8.2 0.0 2.8 2 0 0 2 2 2 0 F-box domain HET PF06985.11 CCM05326.1 - 5.2e-26 91.7 0.0 1.1e-25 90.7 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3630 PF12305.8 CCM05327.1 - 0.13 12.3 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3630) GP4 PF03010.14 CCM05328.1 - 0.06 13.3 0.0 0.088 12.7 0.0 1.2 1 0 0 1 1 1 0 GP4 F-box-like PF12937.7 CCM05330.1 - 0.00019 21.3 0.8 0.00045 20.1 0.8 1.7 1 0 0 1 1 1 1 F-box-like PIG-X PF08320.12 CCM05331.1 - 9.3e-40 136.8 0.0 1.1e-39 136.6 0.0 1.0 1 0 0 1 1 1 1 PIG-X / PBN1 6PF2K PF01591.18 CCM05332.1 - 8.6e-73 244.3 0.1 1.2e-72 243.8 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CCM05332.1 - 3.9e-37 127.8 0.0 7.5e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CCM05332.1 - 2.9e-06 27.5 0.1 5.1e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CCM05332.1 - 0.0055 17.1 0.0 0.01 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain GBP PF02263.19 CCM05332.1 - 0.12 11.7 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain KTI12 PF08433.10 CCM05332.1 - 0.15 11.5 0.0 0.25 10.7 0.0 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 Glyco_transf_8 PF01501.20 CCM05333.1 - 0.00016 21.3 0.0 0.00028 20.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 CCM05333.1 - 0.0031 17.0 0.0 0.0097 15.3 0.0 1.8 2 0 0 2 2 2 1 Glucosyltransferase 24 DUF1627 PF07789.12 CCM05333.1 - 0.009 15.7 0.1 0.027 14.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1627) Nucleotid_trans PF03407.16 CCM05333.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.5 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase ERAP1_C PF11838.8 CCM05334.1 - 6e-63 213.3 1.4 2.1e-62 211.5 0.8 1.9 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 CCM05334.1 - 2.7e-31 109.2 0.1 3e-27 96.0 0.0 2.8 2 1 1 3 3 3 2 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 CCM05334.1 - 4.6e-26 91.7 0.0 4.7e-22 78.6 0.0 2.4 2 0 0 2 2 2 2 Peptidase family M1 domain Aldo_ket_red PF00248.21 CCM05335.1 - 1.2e-57 195.4 0.0 1.8e-57 194.8 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Chlam_vir PF05475.11 CCM05335.1 - 0.15 11.8 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Pgp3 C-terminal domain DUF3602 PF12223.8 CCM05340.1 - 1.1e-16 61.2 23.7 0.0002 21.9 2.9 4.3 1 1 3 4 4 4 4 Protein of unknown function (DUF3602) zf-CW PF07496.15 CCM05341.1 - 0.37 10.9 0.1 0.37 10.9 0.1 2.3 3 0 0 3 3 3 0 CW-type Zinc Finger IBR PF01485.21 CCM05342.1 - 6.7e-13 48.7 29.7 2.7e-08 33.9 5.7 3.6 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 CCM05342.1 - 7.3e-07 29.1 6.4 7.3e-07 29.1 6.4 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CCM05342.1 - 0.0001 22.4 5.8 0.0001 22.4 5.8 3.9 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 CCM05342.1 - 0.00014 21.7 4.3 0.00014 21.7 4.3 3.6 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM05342.1 - 0.00066 19.5 3.7 0.00066 19.5 3.7 4.4 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCM05342.1 - 0.00078 19.7 4.8 0.00078 19.7 4.8 3.9 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 CCM05342.1 - 0.0019 18.0 4.0 0.0019 18.0 4.0 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Eapp_C PF10238.9 CCM05342.1 - 3.6 7.7 11.1 0.62 10.1 4.2 3.0 3 0 0 3 3 3 0 E2F-associated phosphoprotein IBR PF01485.21 CCM05343.1 - 2.5e-13 50.0 32.7 2.6e-08 33.9 6.6 3.9 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-CCCH PF00642.24 CCM05343.1 - 8.4e-12 44.7 16.1 1e-05 25.3 6.1 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCM05343.1 - 2e-10 40.2 14.0 2.8e-07 30.2 4.6 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CCM05343.1 - 3.3e-10 39.7 17.1 7.6e-05 22.6 2.5 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-RING_UBOX PF13445.6 CCM05343.1 - 7.6e-07 29.0 5.3 7.6e-07 29.0 5.3 3.0 3 0 0 3 3 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CCM05343.1 - 6.6e-05 23.0 5.6 6.6e-05 23.0 5.6 3.9 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CCM05343.1 - 0.0002 21.6 3.8 0.0002 21.6 3.8 3.8 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4 PF00097.25 CCM05343.1 - 0.00021 21.1 3.4 0.00021 21.1 3.4 3.6 3 2 2 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM05343.1 - 0.0003 20.6 2.8 0.0003 20.6 2.8 4.1 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 CCM05343.1 - 0.00052 19.8 0.1 0.26 11.1 0.0 3.7 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_2 PF13923.6 CCM05343.1 - 0.0012 18.7 2.8 0.0012 18.7 2.8 3.4 3 1 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 PF14608.6 CCM05343.1 - 0.0072 16.8 3.4 0.0072 16.8 3.4 4.2 4 0 0 4 4 4 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 CCM05343.1 - 0.019 15.6 0.2 0.019 15.6 0.2 3.6 3 1 0 3 3 2 0 Torus domain MFS_1 PF07690.16 CCM05345.1 - 1.4e-10 40.7 23.9 8.1e-06 25.0 2.2 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1 PF07690.16 CCM05346.1 - 2e-12 46.7 21.0 2e-12 46.7 21.0 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily PTR2 PF00854.21 CCM05346.1 - 0.003 16.5 1.7 0.16 10.8 0.1 2.4 2 1 0 2 2 2 2 POT family Pkinase_fungal PF17667.1 CCM05348.1 - 1.5e-68 231.5 1.3 1.9e-68 231.1 1.3 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM05348.1 - 4.2e-13 49.3 0.2 7.6e-13 48.4 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05348.1 - 6.5e-09 35.4 0.1 6.1e-08 32.3 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CCM05348.1 - 0.0046 16.9 0.2 0.043 13.7 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCM05348.1 - 0.0053 16.4 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 CCM05348.1 - 0.025 14.2 0.1 0.043 13.4 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 CCM05348.1 - 0.028 13.8 0.2 0.052 12.9 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PhnA PF03831.14 CCM05348.1 - 0.13 12.1 0.2 2.5 8.0 0.0 2.5 2 0 0 2 2 2 0 PhnA domain SLAC1 PF03595.17 CCM05349.1 - 4.3e-66 223.4 52.6 4.9e-66 223.2 52.6 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Ammonium_transp PF00909.21 CCM05350.1 - 1.7e-116 389.2 31.1 2e-116 389.0 31.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Abhydrolase_3 PF07859.13 CCM05351.1 - 1.9e-65 220.7 0.0 2.2e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCM05351.1 - 1.6e-10 40.5 0.1 5.2e-10 38.8 0.1 1.6 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 CCM05351.1 - 3.4e-06 26.2 0.0 4.5e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 CCM05351.1 - 0.0032 16.4 0.0 0.0044 16.0 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 CCM05351.1 - 0.0033 16.5 0.0 0.0044 16.1 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase Peptidase_S9 PF00326.21 CCM05351.1 - 0.019 14.5 0.0 0.84 9.1 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Snurportin1 PF11538.8 CCM05353.1 - 3.1e-05 24.1 3.0 6.6e-05 23.0 3.0 1.5 1 0 0 1 1 1 1 Snurportin1 DUF563 PF04577.14 CCM05354.1 - 1.8e-17 64.2 0.4 1.6e-16 61.1 0.1 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF563) MA3 PF02847.17 CCM05354.1 - 0.15 12.1 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 MA3 domain Methyltransf_16 PF10294.9 CCM05355.1 - 8e-17 61.5 0.0 1.2e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase GidB PF02527.15 CCM05355.1 - 0.0032 16.8 0.0 0.0048 16.2 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G MTS PF05175.14 CCM05355.1 - 0.092 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 CCM05355.1 - 0.093 12.1 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Mac_assoc PF16628.5 CCM05355.1 - 0.14 12.4 0.1 0.21 11.8 0.1 1.3 1 0 0 1 1 1 0 Unstructured region on maltose acetyltransferase Methyltransf_25 PF13649.6 CCM05355.1 - 0.14 12.9 0.0 0.66 10.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain zf-MYND PF01753.18 CCM05356.1 - 0.04 14.0 5.6 0.071 13.2 5.6 1.4 1 0 0 1 1 1 0 MYND finger DUF3280 PF11684.8 CCM05356.1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2380) PRP3 PF08572.10 CCM05357.1 - 3.6e-72 242.7 7.1 5.8e-72 242.0 7.1 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 CCM05357.1 - 1.8e-45 154.7 1.8 1.9e-45 154.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Ribosomal_L16 PF00252.18 CCM05359.1 - 2.7e-41 140.7 0.2 3.3e-41 140.4 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF677 PF05055.12 CCM05359.1 - 0.27 10.1 0.0 0.4 9.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) DCP1 PF06058.13 CCM05360.1 - 8.8e-23 80.5 0.0 2e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Dcp1-like decapping family LAP1C PF05609.12 CCM05361.1 - 7.5 5.5 20.9 10 5.1 20.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Josephin PF02099.17 CCM05363.1 - 1.4e-39 135.8 0.1 2.4e-39 135.0 0.1 1.3 1 0 0 1 1 1 1 Josephin 3-PAP PF12578.8 CCM05363.1 - 0.019 14.7 0.2 0.082 12.6 0.1 2.0 2 0 0 2 2 2 0 Myotubularin-associated protein TetR_C_6 PF13977.6 CCM05363.1 - 6.7 7.0 10.6 3.8 7.8 3.7 3.3 4 0 0 4 4 4 0 BetI-type transcriptional repressor, C-terminal ATG27 PF09451.10 CCM05364.1 - 1e-62 212.4 0.0 1.2e-62 212.2 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 CCM05364.1 - 5.7e-05 22.3 0.0 9.2e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor Aldo_ket_red PF00248.21 CCM05366.1 - 1.6e-64 218.0 0.0 1.9e-64 217.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 CCM05367.1 - 1.4e-63 215.3 0.0 3.9e-54 184.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 HSP9_HSP12 PF04119.12 CCM05368.1 - 8.4e-23 80.5 5.2 8.4e-23 80.5 5.2 1.6 2 0 0 2 2 2 1 Heat shock protein 9/12 zf-RING_2 PF13639.6 CCM05369.1 - 9.7e-12 45.0 9.2 1.5e-11 44.4 9.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 CCM05369.1 - 1.6e-06 28.0 2.6 4.2e-06 26.7 2.5 1.7 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CCM05369.1 - 3.5e-06 26.6 6.4 3.5e-06 26.6 6.4 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_4 PF14570.6 CCM05369.1 - 3.7e-05 23.4 6.3 5.5e-05 22.9 6.3 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 CCM05369.1 - 4.9e-05 23.1 7.9 7.5e-05 22.5 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCM05369.1 - 0.00018 21.3 3.9 0.0003 20.6 3.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCM05369.1 - 0.00022 21.5 8.9 0.00064 20.0 8.9 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CCM05369.1 - 0.00047 20.0 6.4 0.00072 19.4 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM05369.1 - 0.0078 16.1 5.7 0.012 15.6 5.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCM05369.1 - 0.041 13.7 9.7 0.41 10.5 10.3 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCM05369.1 - 0.1 12.7 7.5 4.8 7.3 3.5 2.4 2 0 0 2 2 2 0 RING-type zinc-finger FANCL_C PF11793.8 CCM05369.1 - 0.11 12.7 5.1 0.25 11.5 5.1 1.6 1 1 0 1 1 1 0 FANCL C-terminal domain UBZ_FAAP20 PF15750.5 CCM05369.1 - 0.47 10.5 3.4 6 6.9 0.5 2.4 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger zinc-ribbons_6 PF07191.12 CCM05369.1 - 0.66 10.0 3.4 1 9.4 3.4 1.3 1 0 0 1 1 1 0 zinc-ribbons RINGv PF12906.7 CCM05369.1 - 0.68 10.1 6.7 1.1 9.4 6.7 1.4 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.6 CCM05369.1 - 1 9.3 7.6 10 6.1 3.9 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 p450 PF00067.22 CCM05371.1 - 2.4e-62 211.2 0.0 5.9e-62 209.9 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM05372.1 - 1.3e-68 231.9 0.0 2.7e-68 230.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM05373.1 - 1.3e-65 222.0 0.0 2.4e-65 221.1 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Sec10 PF07393.11 CCM05375.1 - 1.7e-133 446.6 0.0 2.3e-133 446.2 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 CCM05375.1 - 0.0002 21.2 0.3 0.00063 19.6 0.3 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM05375.1 - 0.002 17.9 0.1 0.0046 16.8 0.1 1.6 1 0 0 1 1 1 1 F-box domain ECM11 PF15463.6 CCM05377.1 - 0.034 14.7 0.0 0.095 13.3 0.0 1.8 1 0 0 1 1 1 0 Extracellular mutant protein 11 4HBT PF03061.22 CCM05378.1 - 3.7e-09 36.8 0.0 5.6e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 CCM05378.1 - 0.0001 22.8 0.0 0.00012 22.5 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 CCM05378.1 - 0.00058 19.2 0.5 0.0029 16.9 0.8 1.7 2 0 0 2 2 2 1 Acyl-ACP thioesterase ECH_1 PF00378.20 CCM05379.1 - 2.9e-78 262.6 0.1 3.4e-78 262.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CCM05379.1 - 1.2e-38 133.5 0.5 3e-34 119.0 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CCM05379.1 - 7.6e-05 22.7 0.1 0.0052 16.8 0.0 2.3 2 0 0 2 2 2 2 Peptidase family S49 WD40 PF00400.32 CCM05380.1 - 2.3e-23 82.0 6.9 3e-05 24.7 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM05380.1 - 0.00077 19.7 0.1 0.0053 17.0 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCM05380.1 - 0.0028 17.0 0.0 0.0089 15.4 0.0 1.8 2 0 0 2 2 2 1 WD40-like domain Copper-fist PF00649.18 CCM05381.1 - 5.1e-22 77.1 1.1 1e-21 76.1 1.1 1.6 1 0 0 1 1 1 1 Copper fist DNA binding domain Aminotran_1_2 PF00155.21 CCM05382.1 - 1.3e-35 123.3 0.0 2.9e-35 122.1 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II DUF775 PF05603.12 CCM05383.1 - 6.6e-40 136.8 0.0 7.6e-34 117.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF775) PQ-loop PF04193.14 CCM05384.1 - 8.6e-10 38.3 0.6 8.6e-10 38.3 0.6 1.9 2 0 0 2 2 2 1 PQ loop repeat MPS-4 PF17523.2 CCM05384.1 - 0.084 13.0 1.2 0.1 12.7 0.1 1.7 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Adap_comp_sub PF00928.21 CCM05385.1 - 1e-71 241.4 0.0 2e-71 240.4 0.0 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Dus PF01207.17 CCM05385.1 - 3.2e-51 174.3 0.0 8.2e-51 172.9 0.0 1.6 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) Clat_adaptor_s PF01217.20 CCM05385.1 - 1.1e-06 28.6 0.6 1.9e-06 27.9 0.6 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain zf-CCCH_4 PF18044.1 CCM05385.1 - 7.7e-06 25.6 9.5 0.00071 19.3 0.6 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 CCM05385.1 - 0.0001 22.1 4.9 0.031 14.2 0.1 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CCM05385.1 - 0.00036 21.2 1.3 0.44 11.3 0.2 2.4 2 0 0 2 2 2 2 Torus domain zf-CCCH_2 PF14608.6 CCM05385.1 - 0.55 10.8 3.0 1.3 9.6 0.3 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 CCM05385.1 - 0.9 9.7 10.9 0.45 10.6 0.8 2.5 2 0 0 2 2 2 0 Zinc finger domain HMGL-like PF00682.19 CCM05386.1 - 6.1e-43 147.3 0.3 2e-42 145.6 0.3 1.7 1 1 0 1 1 1 1 HMGL-like DUF4536 PF15055.6 CCM05387.1 - 1.7e-07 31.4 1.1 1.7e-07 31.4 1.1 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4536) SKG6 PF08693.10 CCM05388.1 - 1.1 8.7 4.2 2.2 7.7 4.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Fungal_trans PF04082.18 CCM05389.1 - 1.2e-33 116.3 0.0 3.3e-33 114.8 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM05389.1 - 6.4e-07 29.4 13.5 1.1e-06 28.7 13.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MBOAT_2 PF13813.6 CCM05391.1 - 5.1e-22 77.9 3.7 8e-22 77.3 3.7 1.3 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family NOA36 PF06524.12 CCM05392.1 - 0.86 8.9 3.8 0.74 9.1 3.8 1.0 1 0 0 1 1 1 0 NOA36 protein CNDH2_M PF16869.5 CCM05392.1 - 3.2 8.5 9.5 3.5 8.3 9.5 1.1 1 0 0 1 1 1 0 PF16858 SUZ PF12752.7 CCM05393.1 - 1.4e-12 48.2 0.5 1.4e-12 48.2 0.5 2.5 1 1 1 2 2 2 1 SUZ domain Aminotran_1_2 PF00155.21 CCM05394.1 - 4.2e-52 177.5 0.0 2.2e-44 152.1 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II OKR_DC_1 PF01276.20 CCM05394.1 - 1.8e-05 23.6 0.0 4.5e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Aminotran_5 PF00266.19 CCM05394.1 - 0.0043 16.1 0.0 0.0076 15.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V UDPG_MGDP_dh_N PF03721.14 CCM05395.1 - 1.9e-58 197.1 0.0 3e-58 196.5 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 CCM05395.1 - 5.1e-35 120.1 0.1 1.1e-33 115.8 0.1 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 CCM05395.1 - 7.7e-31 106.2 0.0 1.5e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_7 PF13241.6 CCM05395.1 - 0.0094 16.4 0.0 0.53 10.8 0.0 2.8 2 1 0 2 2 2 1 Putative NAD(P)-binding F420_oxidored PF03807.17 CCM05395.1 - 0.0097 16.5 0.7 2.9 8.6 0.0 3.2 3 1 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 CCM05395.1 - 0.021 14.2 0.0 0.064 12.5 0.0 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 CCM05395.1 - 0.027 14.6 0.0 0.39 10.9 0.0 2.4 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase HET PF06985.11 CCM05396.1 - 3.7e-16 59.8 0.0 6.1e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Striatin PF08232.12 CCM05397.1 - 0.22 12.1 1.8 0.79 10.3 1.8 1.9 1 0 0 1 1 1 0 Striatin family DUF4436 PF14494.6 CCM05398.1 - 3.4e-14 52.8 2.4 3.4e-14 52.8 2.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4436) Proteasome PF00227.26 CCM05399.1 - 2.8e-38 131.3 0.0 3.4e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit ANAPC4_WD40 PF12894.7 CCM05400.1 - 4.2e-19 68.6 8.2 8.9e-09 35.5 0.1 4.2 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCM05400.1 - 2.7e-14 53.3 20.6 1.7e-05 25.5 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.11 CCM05400.1 - 1.7e-05 24.8 0.1 0.0049 16.8 0.0 3.0 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CCM05400.1 - 0.012 14.6 0.1 2.4 7.0 0.0 2.9 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein NifZ PF04319.13 CCM05400.1 - 0.22 11.3 0.2 0.72 9.7 0.0 1.9 2 0 0 2 2 2 0 NifZ domain Pro-kuma_activ PF09286.11 CCM05401.1 - 4.6e-43 146.9 0.0 1.3e-42 145.5 0.0 1.8 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM05401.1 - 0.0019 17.5 1.2 0.0032 16.8 1.2 1.3 1 0 0 1 1 1 1 Subtilase family Vma12 PF11712.8 CCM05402.1 - 3.7e-12 46.5 0.0 5.7e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4231 PF14015.6 CCM05402.1 - 0.016 15.7 0.2 0.032 14.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) GspL_C PF12693.7 CCM05402.1 - 0.19 11.6 0.8 1.7 8.4 0.0 2.6 3 0 0 3 3 3 0 GspL periplasmic domain Atx10homo_assoc PF09759.9 CCM05403.1 - 1.7e-25 88.9 0.1 3.6e-25 87.8 0.1 1.5 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 CCM05403.1 - 0.0048 16.9 0.1 0.017 15.2 0.0 2.1 1 1 0 1 1 1 1 Armadillo/beta-catenin-like repeat DUF913 PF06025.12 CCM05403.1 - 0.11 11.5 0.0 0.98 8.3 0.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Leo1 PF04004.13 CCM05404.1 - 1.5e-52 177.8 0.1 1.5e-52 177.8 0.1 1.9 2 0 0 2 2 2 1 Leo1-like protein TPR_1 PF00515.28 CCM05405.1 - 2.6e-07 30.2 3.9 0.11 12.3 0.0 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CCM05405.1 - 2.2e-06 27.4 3.8 0.2 11.9 0.2 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CCM05405.1 - 3.5e-05 24.2 0.6 0.043 14.3 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CCM05405.1 - 6.2e-05 23.6 1.0 0.72 10.5 0.6 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 CCM05405.1 - 0.00037 20.5 4.3 0.0057 16.7 0.1 2.7 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 CCM05405.1 - 0.0084 16.4 2.9 3.2 8.1 0.2 3.0 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 CCM05405.1 - 0.014 15.1 4.0 0.053 13.2 0.2 2.5 2 0 0 2 2 2 0 TPR repeat TPR_8 PF13181.6 CCM05405.1 - 0.017 15.3 0.6 49 4.5 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CCM05405.1 - 0.018 14.6 0.4 6.4 6.4 0.1 2.5 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_14 PF13428.6 CCM05405.1 - 0.038 14.8 3.3 19 6.4 0.1 4.0 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 CCM05405.1 - 0.051 13.9 0.5 14 6.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Rnk_N PF14760.6 CCM05405.1 - 0.25 11.9 1.8 0.9 10.1 0.4 2.5 2 0 0 2 2 2 0 Rnk N-terminus TPR_6 PF13174.6 CCM05405.1 - 0.31 11.8 1.9 1.7 9.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCM05405.1 - 0.33 11.1 2.4 12 6.2 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Pkinase_fungal PF17667.1 CCM05406.1 - 2.7e-05 23.1 0.1 2.9e-05 23.0 0.1 1.0 1 0 0 1 1 1 1 Fungal protein kinase FA_desaturase PF00487.24 CCM05407.1 - 3.8e-24 85.9 28.9 5.7e-24 85.3 28.9 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CCM05407.1 - 3.7e-05 23.9 0.0 9.2e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3474) DNA_pol_A_exo1 PF01612.20 CCM05408.1 - 2e-07 30.9 0.1 3.2e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 3'-5' exonuclease DnaJ PF00226.31 CCM05409.1 - 5.4e-17 61.7 0.4 5.4e-17 61.7 0.4 2.3 2 0 0 2 2 2 1 DnaJ domain EST1_DNA_bind PF10373.9 CCM05411.1 - 1.5e-26 93.6 0.0 1e-22 81.0 0.0 2.2 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain EST1 PF10374.9 CCM05411.1 - 3.2e-24 86.1 0.2 8.5e-24 84.7 0.2 1.8 1 0 0 1 1 1 1 Telomerase activating protein Est1 TPR_2 PF07719.17 CCM05411.1 - 0.031 14.4 1.1 0.19 12.0 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DNase_II PF03265.15 CCM05411.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Deoxyribonuclease II SNF2_N PF00176.23 CCM05412.1 - 7.7e-70 235.3 0.5 2.1e-69 233.9 0.4 1.5 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CCM05412.1 - 2.2e-20 73.1 0.0 4.3e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM05412.1 - 6.8e-06 26.2 0.0 1.8e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-piccolo PF05715.13 CCM05412.1 - 0.008 16.3 1.4 0.017 15.2 1.4 1.5 1 0 0 1 1 1 1 Piccolo Zn-finger TPT PF03151.16 CCM05413.1 - 7.7e-19 68.1 22.0 9.4e-19 67.8 22.0 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CCM05413.1 - 0.0039 17.3 38.0 0.021 15.0 13.4 2.4 2 1 0 2 2 2 2 EamA-like transporter family Mre11_DNA_bind PF04152.14 CCM05414.1 - 2.6e-50 171.0 0.5 2.6e-50 171.0 0.5 2.3 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 CCM05414.1 - 4.1e-12 47.0 2.1 9.5e-12 45.8 2.1 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CCM05414.1 - 1.2e-05 25.6 0.0 0.00012 22.3 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ArfGap PF01412.18 CCM05416.1 - 1.5e-20 73.4 0.1 2.1e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF5572 PF17733.1 CCM05417.1 - 1.1e-09 38.0 0.0 1.9e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Trypan_PARP PF05887.11 CCM05417.1 - 0.025 14.6 0.1 0.064 13.2 0.1 1.8 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PAPS_reduct PF01507.19 CCM05418.1 - 2.6e-28 99.2 0.0 3.7e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family RVT_3 PF13456.6 CCM05418.1 - 0.22 11.4 0.0 0.33 10.8 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase-like TPR_14 PF13428.6 CCM05419.1 - 1.7e-21 75.1 30.9 0.00038 21.0 0.1 12.7 5 2 6 13 13 13 6 Tetratricopeptide repeat HAT PF02184.16 CCM05419.1 - 9.1e-20 70.3 59.8 2e-08 34.0 3.0 13.6 14 2 0 14 14 13 5 HAT (Half-A-TPR) repeat Suf PF05843.14 CCM05419.1 - 1.1e-15 58.5 15.5 0.00019 21.5 0.0 6.2 4 1 1 6 6 6 4 Suppressor of forked protein (Suf) TPR_2 PF07719.17 CCM05419.1 - 6.6e-14 50.8 1.6 0.22 11.7 0.0 8.3 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 CCM05419.1 - 6.5e-13 49.0 4.1 0.12 12.9 0.0 8.2 7 2 1 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CCM05419.1 - 1.8e-07 31.7 19.5 0.0042 17.7 0.0 7.9 5 3 2 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 CCM05419.1 - 2.3e-07 30.5 2.1 14 6.2 0.0 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_17 PF13431.6 CCM05419.1 - 4.1e-07 29.9 2.3 0.0054 17.0 0.0 6.2 6 1 1 7 7 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM05419.1 - 5.2e-06 26.6 3.9 0.32 11.3 0.1 6.2 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCM05419.1 - 7.7e-06 25.3 18.9 0.099 11.8 0.1 5.8 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM05419.1 - 1.3e-05 24.7 0.0 4.1 7.2 0.0 5.1 4 0 0 4 4 4 1 TPR repeat TPR_1 PF00515.28 CCM05419.1 - 4.7e-05 23.0 0.2 10 6.1 0.0 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat SNAP PF14938.6 CCM05419.1 - 6e-05 22.6 3.9 0.009 15.5 0.2 3.7 2 1 2 4 4 4 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 CCM05419.1 - 0.00036 21.0 12.2 23 5.9 0.2 7.8 8 1 0 8 8 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CCM05419.1 - 0.0013 18.6 8.8 9.6 6.5 0.0 6.8 7 0 0 7 7 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CCM05419.1 - 0.0016 18.4 18.1 1.9 8.5 0.1 7.1 5 2 1 6 6 6 1 Mad3/BUB1 homology region 1 U3_assoc_6 PF08640.11 CCM05419.1 - 0.017 15.1 15.5 0.37 10.9 0.4 6.6 5 3 3 8 8 7 0 U3 small nucleolar RNA-associated protein 6 TPR_9 PF13371.6 CCM05419.1 - 0.13 12.5 11.7 10 6.3 0.1 5.4 5 1 2 7 7 6 0 Tetratricopeptide repeat c-SKI_SMAD_bind PF08782.10 CCM05419.1 - 1.8 8.9 7.7 4.8 7.5 0.4 4.5 4 1 1 5 5 5 0 c-SKI Smad4 binding domain TPR_10 PF13374.6 CCM05419.1 - 7.5 6.6 12.8 81 3.3 0.2 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat RNA_pol_Rpc34 PF05158.12 CCM05420.1 - 4.9e-78 262.9 8.9 1.8e-67 228.1 3.0 2.3 2 1 0 2 2 2 2 RNA polymerase Rpc34 subunit Borrelia_P83 PF05262.11 CCM05420.1 - 7.5e-05 21.4 21.4 7.8e-05 21.4 21.4 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein AF-4 PF05110.13 CCM05420.1 - 0.00046 18.5 39.8 0.00064 18.0 39.8 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein GREB1 PF15782.5 CCM05420.1 - 0.2 8.8 26.8 0.26 8.4 26.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SRP-alpha_N PF04086.13 CCM05420.1 - 6.3 6.6 49.5 13 5.6 49.5 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MFS_1 PF07690.16 CCM05421.1 - 3e-19 69.2 67.3 2e-16 59.9 41.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BPL_N PF09825.9 CCM05422.1 - 3.2e-43 148.2 0.0 5.7e-25 88.2 0.0 2.1 2 0 0 2 2 2 2 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 CCM05422.1 - 5.5e-23 81.3 0.0 8.2e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DSRB PF10781.9 CCM05422.1 - 0.14 11.8 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Dextransucrase DSRB C2 PF00168.30 CCM05424.1 - 4.2e-27 94.4 0.0 2e-15 57.0 0.0 2.4 2 0 0 2 2 2 2 C2 domain ddrB-ParB PF18763.1 CCM05424.1 - 0.16 12.1 0.2 0.37 10.9 0.2 1.6 1 0 0 1 1 1 0 ddrB-like ParB superfamily domain Epimerase PF01370.21 CCM05426.1 - 4.1e-49 167.2 0.0 9.6e-49 166.0 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM05426.1 - 1.5e-14 54.2 0.1 1.9e-13 50.6 0.0 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CCM05426.1 - 2.1e-06 27.1 0.2 0.00097 18.4 0.2 3.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CCM05426.1 - 1.9e-05 23.9 0.0 4.3e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CCM05426.1 - 0.0037 16.3 0.0 0.0085 15.1 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family CM1 PF03026.15 CCM05427.1 - 0.064 12.6 0.0 0.093 12.1 0.0 1.2 1 0 0 1 1 1 0 Influenza C virus M1 protein Semialdhyde_dh PF01118.24 CCM05427.1 - 0.081 13.4 0.0 0.18 12.3 0.0 1.6 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Fungus-induced PF10917.8 CCM05429.1 - 0.6 10.5 3.2 5 7.5 1.7 2.3 2 0 0 2 2 2 0 Fungus-induced protein eIF3_N PF09440.10 CCM05430.1 - 1.2e-27 97.0 2.6 2.3e-27 96.0 1.5 2.1 3 0 0 3 3 3 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 CCM05430.1 - 2.1e-09 37.8 0.2 7.3e-09 36.1 0.1 2.0 2 0 0 2 2 2 1 PCI domain CagZ PF09053.10 CCM05430.1 - 0.29 10.7 2.7 0.84 9.2 0.1 2.1 2 0 0 2 2 2 0 CagZ PQ-loop PF04193.14 CCM05431.1 - 4.4e-24 84.0 3.3 2.9e-11 43.0 0.1 2.6 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 CCM05431.1 - 1.1 10.0 6.1 0.18 12.6 2.3 1.6 2 0 0 2 2 2 0 ER lumen protein retaining receptor ox_reductase_C PF08635.10 CCM05432.1 - 3.6e-32 111.0 0.0 5.9e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 CCM05432.1 - 7.6e-15 55.8 0.0 1.2e-14 55.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Mid2 PF04478.12 CCM05433.1 - 0.00051 19.9 0.4 0.00051 19.9 0.4 2.9 2 1 0 2 2 2 1 Mid2 like cell wall stress sensor adh_short PF00106.25 CCM05434.1 - 5.8e-30 104.2 0.0 2.2e-24 86.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05434.1 - 2.8e-19 69.6 0.0 1.2e-17 64.3 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05434.1 - 2e-08 34.4 0.0 3.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM05434.1 - 0.00011 21.7 0.1 0.00063 19.3 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM05434.1 - 0.066 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase GcpE PF04551.14 CCM05434.1 - 0.069 12.2 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 GcpE protein HECT PF00632.25 CCM05435.1 - 2.9e-93 312.7 0.0 4.4e-93 312.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 CCM05435.1 - 0.017 14.9 1.0 0.046 13.5 1.0 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF397 PF04149.12 CCM05435.1 - 0.12 12.5 0.1 0.33 11.0 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF397) Arginase PF00491.21 CCM05436.1 - 1.4e-71 241.2 0.1 7.2e-37 127.4 0.0 2.1 1 1 1 2 2 2 2 Arginase family UPF0489 PF12640.7 CCM05436.1 - 0.19 11.9 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain MatE PF01554.18 CCM05437.1 - 1.1e-57 194.2 20.6 1.4e-29 102.8 5.0 2.5 2 0 0 2 2 2 2 MatE UPF0242 PF06785.11 CCM05437.1 - 0.00059 20.0 0.3 0.0033 17.5 0.0 2.0 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus MatE PF01554.18 CCM05438.1 - 2.6e-53 180.0 29.5 4.7e-28 97.9 9.4 2.7 3 0 0 3 3 3 2 MatE UPF0242 PF06785.11 CCM05438.1 - 0.00089 19.4 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Zip PF02535.22 CCM05440.1 - 1.4e-25 90.3 17.1 1.2e-24 87.2 17.1 2.3 1 1 0 1 1 1 1 ZIP Zinc transporter UPF0016 PF01169.19 CCM05440.1 - 2.4 8.6 0.0 2.4 8.6 0.0 3.2 3 1 0 3 3 3 0 Uncharacterized protein family UPF0016 Fe-ADH PF00465.19 CCM05441.1 - 4.6e-59 200.1 2.1 5.3e-59 199.9 2.1 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCM05441.1 - 1.1e-32 113.7 0.2 1.4e-32 113.4 0.2 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 CCM05441.1 - 0.00041 19.6 1.7 0.084 12.0 0.1 2.6 2 1 0 2 2 2 2 3-dehydroquinate synthase PFK PF00365.20 CCM05441.1 - 0.033 13.5 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphofructokinase DUF5127 PF17168.4 CCM05442.1 - 3.7e-80 269.0 7.8 4.9e-80 268.6 7.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CCM05442.1 - 3.1e-32 111.6 0.4 1.1e-31 109.8 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4965) Glyco_hydr_116N PF12215.8 CCM05442.1 - 0.011 15.2 0.6 0.018 14.6 0.6 1.3 1 0 0 1 1 1 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term DUF3713 PF12506.8 CCM05442.1 - 0.079 13.3 0.2 0.16 12.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) ETF PF01012.21 CCM05443.1 - 1.8e-35 122.4 0.7 3.1e-35 121.7 0.7 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CCM05443.1 - 3.2e-32 110.4 0.4 5.6e-32 109.6 0.4 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain FAD_binding_3 PF01494.19 CCM05444.1 - 6.2e-05 22.4 0.0 7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Piwi PF02171.17 CCM05444.1 - 0.22 10.7 0.0 0.27 10.4 0.0 1.1 1 0 0 1 1 1 0 Piwi domain NUC173 PF08161.12 CCM05445.1 - 4.8e-56 189.7 0.7 8.4e-54 182.3 0.1 3.0 2 0 0 2 2 2 2 NUC173 domain HEAT PF02985.22 CCM05445.1 - 0.013 15.6 1.5 2.5 8.6 0.0 4.1 5 0 0 5 5 5 0 HEAT repeat MMS19_C PF12460.8 CCM05445.1 - 0.027 13.6 0.2 0.027 13.6 0.2 4.7 5 1 0 5 5 5 0 RNAPII transcription regulator C-terminal Acyltransferase PF01553.21 CCM05446.1 - 3.3e-12 46.2 0.0 1.4e-11 44.1 0.0 2.1 3 0 0 3 3 3 1 Acyltransferase 7TM-7TMR_HD PF07698.11 CCM05447.1 - 0.28 10.9 5.7 0.66 9.7 3.1 2.1 2 0 0 2 2 2 0 7TM receptor with intracellular HD hydrolase Tetraspanin PF00335.20 CCM05447.1 - 0.77 9.4 4.1 2.2 7.9 0.1 2.6 3 0 0 3 3 3 0 Tetraspanin family SUR7 PF06687.12 CCM05447.1 - 7.7 6.1 12.0 48 3.5 11.3 2.4 1 1 0 1 1 1 0 SUR7/PalI family Choline_transpo PF04515.12 CCM05448.1 - 6.2e-19 68.4 11.3 6.2e-19 68.4 11.3 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter PP2C PF00481.21 CCM05449.1 - 5.1e-66 222.9 0.1 3.9e-52 177.4 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 CCM05449.1 - 0.023 14.6 0.4 0.12 12.2 0.4 2.1 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) W2 PF02020.18 CCM05450.1 - 2.4e-19 69.3 1.5 3.8e-19 68.6 0.2 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Recombinase PF07508.13 CCM05450.1 - 0.12 12.8 0.2 6 7.3 0.2 2.5 1 1 0 1 1 1 0 Recombinase Fungal_trans PF04082.18 CCM05451.1 - 2e-07 30.3 0.0 3.3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box PF00646.33 CCM05452.1 - 0.026 14.4 0.5 0.048 13.6 0.5 1.4 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 CCM05452.1 - 0.078 12.9 0.3 0.13 12.2 0.3 1.4 1 0 0 1 1 1 0 F-box-like Mem_trans PF03547.18 CCM05453.1 - 1.4e-22 79.7 20.9 2.7e-12 45.8 1.6 2.0 2 0 0 2 2 2 2 Membrane transport protein NmrA PF05368.13 CCM05454.1 - 1.7e-19 70.3 0.0 4.2e-19 69.0 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 CCM05454.1 - 1e-06 28.8 0.0 1.6e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CCM05454.1 - 6.9e-05 23.1 0.0 0.0001 22.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 CCM05454.1 - 0.005 17.0 0.0 0.0082 16.3 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 CCM05454.1 - 0.016 15.7 0.1 0.041 14.3 0.1 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 CCM05454.1 - 0.087 13.5 0.0 0.34 11.6 0.0 2.0 2 1 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Epimerase PF01370.21 CCM05454.1 - 0.11 11.9 0.1 0.31 10.4 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CCM05455.1 - 7.2e-15 55.2 0.4 1.1e-14 54.5 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family Semialdhyde_dh PF01118.24 CCM05455.1 - 5.9e-05 23.5 0.1 0.00085 19.8 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CCM05455.1 - 0.00017 21.9 0.0 0.00034 20.9 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 CCM05455.1 - 0.0013 18.6 0.0 0.002 18.1 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding p450 PF00067.22 CCM05456.1 - 7.6e-51 173.3 0.0 9.5e-51 173.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Mnd1 PF03962.15 CCM05457.1 - 4.4e-30 103.8 0.3 7e-30 103.1 0.3 1.3 1 0 0 1 1 1 1 Mnd1 HTH domain Penicillinase_R PF03965.16 CCM05457.1 - 0.16 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Penicillinase repressor Oxidored_q6 PF01058.22 CCM05459.1 - 2.2e-22 79.3 0.1 3.3e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Pkinase PF00069.25 CCM05460.1 - 4.8e-48 163.8 0.0 4.5e-34 118.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05460.1 - 2.3e-17 63.2 0.0 7.1e-17 61.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM05460.1 - 0.0003 20.8 0.0 0.00072 19.5 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCM05460.1 - 0.0013 18.1 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CCM05460.1 - 0.0021 17.7 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 CCM05460.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HhH-GPD PF00730.25 CCM05461.1 - 2.6e-15 56.8 0.0 4.9e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein PLA2_B PF01735.18 CCM05463.1 - 8e-83 278.5 3.9 1e-82 278.1 3.9 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain SecY PF00344.20 CCM05464.1 - 9.9e-74 248.3 10.6 1.2e-73 248.0 10.6 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 CCM05464.1 - 3.8e-19 68.2 0.2 2.2e-18 65.8 0.2 2.2 2 0 0 2 2 2 1 Plug domain of Sec61p DUF805 PF05656.14 CCM05464.1 - 7 7.1 9.3 0.37 11.2 0.2 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF805) DUF4449 PF14613.6 CCM05466.1 - 4.2e-13 49.7 0.0 4.2e-13 49.7 0.0 3.6 3 1 1 4 4 4 1 Protein of unknown function (DUF4449) HAMP PF00672.25 CCM05466.1 - 1.6 9.1 4.3 0.84 10.1 0.3 2.6 3 0 0 3 3 3 0 HAMP domain Seryl_tRNA_N PF02403.22 CCM05466.1 - 3.7 7.8 6.0 40 4.5 0.7 3.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AMP-binding PF00501.28 CCM05467.1 - 1.5e-86 290.6 0.0 1.8e-86 290.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM05467.1 - 3e-14 53.7 0.1 9.1e-14 52.2 0.1 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PLA2_B PF01735.18 CCM05468.1 - 1.3e-83 281.0 3.0 1.8e-83 280.7 3.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain CC PF04942.14 CCM05468.1 - 0.33 11.2 0.1 0.33 11.2 0.1 2.2 2 0 0 2 2 2 0 CC domain ThiF PF00899.21 CCM05469.1 - 7.6e-40 136.8 0.0 1.5e-39 135.8 0.0 1.4 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CCM05469.1 - 0.00011 22.5 0.5 0.0007 19.9 0.5 2.1 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CCM05469.1 - 0.015 15.7 0.1 0.039 14.4 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 CCM05469.1 - 0.087 12.7 0.1 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CCM05469.1 - 0.19 11.0 0.1 0.33 10.2 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MFS_1 PF07690.16 CCM05470.1 - 4.6e-18 65.3 50.2 4.6e-18 65.3 50.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Arteri_Gl PF00951.18 CCM05470.1 - 0.19 11.5 4.5 0.12 12.1 1.5 2.0 1 1 1 2 2 2 0 Arterivirus GL envelope glycoprotein GBP_PSP PF02425.15 CCM05470.1 - 0.66 9.7 5.0 1.3 8.7 5.0 1.4 1 0 0 1 1 1 0 Paralytic/GBP/PSP peptide p450 PF00067.22 CCM05472.1 - 3.7e-66 223.8 0.0 5e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GMC_oxred_N PF00732.19 CCM05473.1 - 1.9e-43 149.0 0.0 2.5e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05473.1 - 6.1e-36 124.1 0.0 1.1e-35 123.2 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase HEPN_AbiU2 PF18734.1 CCM05474.1 - 0.12 11.9 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 AbiU2 Vps26 PF03643.15 CCM05475.1 - 5e-128 425.9 2.4 5.7e-128 425.7 2.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 CCM05475.1 - 0.0027 18.2 0.1 4.4 7.8 0.0 3.1 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCM05475.1 - 0.0032 17.5 2.0 0.61 10.1 0.1 3.4 3 1 1 4 4 4 2 Arrestin (or S-antigen), N-terminal domain CLN3 PF02487.17 CCM05476.1 - 9.4e-91 304.8 0.0 1.1e-90 304.5 0.0 1.0 1 0 0 1 1 1 1 CLN3 protein TssN PF17555.2 CCM05476.1 - 0.017 14.5 0.5 0.028 13.8 0.0 1.5 2 0 0 2 2 2 0 Type VI secretion system, TssN AAA_5 PF07728.14 CCM05477.1 - 2.7e-64 215.3 0.0 2.7e-26 92.2 0.0 3.6 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCM05477.1 - 0.0034 17.8 0.4 3.2 8.1 0.0 4.0 3 1 1 4 4 4 1 AAA ATPase domain PKI PF02827.16 CCM05477.1 - 0.23 11.7 0.9 0.45 10.8 0.1 2.0 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor Myb_DNA-binding PF00249.31 CCM05478.1 - 2.5e-08 34.0 0.2 5.5e-08 32.9 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCM05478.1 - 0.0063 16.7 0.3 0.022 15.0 0.3 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain LXG PF04740.12 CCM05478.1 - 0.011 15.4 1.0 0.031 14.0 1.0 1.7 1 0 0 1 1 1 0 LXG domain of WXG superfamily RecG_N PF17190.4 CCM05478.1 - 1.8 9.4 6.7 23 5.8 1.0 3.2 3 1 0 3 3 3 0 RecG N-terminal helical domain FliT PF05400.13 CCM05478.1 - 8.2 7.3 9.2 17 6.3 2.5 2.9 2 0 0 2 2 2 0 Flagellar protein FliT Aminotran_1_2 PF00155.21 CCM05479.1 - 4e-39 134.8 0.0 4.8e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II OKR_DC_1 PF01276.20 CCM05479.1 - 0.015 14.0 0.0 0.044 12.5 0.0 1.8 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 CCM05479.1 - 0.08 11.4 0.0 0.74 8.3 0.0 2.0 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme adh_short PF00106.25 CCM05480.1 - 5.5e-25 88.0 0.0 1.8e-23 83.0 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05480.1 - 4.3e-11 42.8 0.0 1.7e-10 40.8 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF2630 PF10944.8 CCM05480.1 - 0.11 12.9 3.2 2 8.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) Epimerase PF01370.21 CCM05480.1 - 0.18 11.2 0.0 0.29 10.6 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_4 PF04669.13 CCM05481.1 - 2.8e-14 53.1 1.3 2.1e-09 37.2 0.1 2.2 1 1 1 2 2 2 2 Polysaccharide biosynthesis adh_short_C2 PF13561.6 CCM05482.1 - 1.3e-47 162.3 0.0 2.1e-47 161.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM05482.1 - 2.1e-46 157.9 0.0 3.3e-46 157.2 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM05482.1 - 4.4e-06 26.7 0.0 6.6e-06 26.1 0.0 1.3 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CCM05482.1 - 0.00022 20.6 0.2 0.00052 19.4 0.0 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 CCM05482.1 - 0.0012 18.4 0.0 0.61 9.5 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CCM05482.1 - 0.017 15.0 0.1 0.025 14.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CCM05482.1 - 0.083 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Cadherin_4 PF17803.1 CCM05482.1 - 0.099 13.3 0.2 0.23 12.1 0.2 1.6 1 0 0 1 1 1 0 Bacterial cadherin-like domain Big_9 PF17963.1 CCM05482.1 - 0.13 13.0 0.2 0.33 11.7 0.2 1.7 1 0 0 1 1 1 0 Bacterial Ig domain Cadherin_5 PF17892.1 CCM05482.1 - 0.15 12.0 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 Cadherin-like domain GREB1 PF15782.5 CCM05483.1 - 4.1 4.4 12.1 9.3 3.2 12.1 1.5 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer U1snRNP70_N PF12220.8 CCM05483.1 - 5.8 7.6 17.9 2.3 8.9 7.1 3.2 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Sel1 PF08238.12 CCM05485.1 - 8.9e-10 38.9 12.4 0.00017 22.2 0.1 4.9 5 0 0 5 5 5 4 Sel1 repeat DUF294_C PF10335.9 CCM05485.1 - 0.05 13.4 0.4 0.095 12.5 0.4 1.3 1 0 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain TPR_1 PF00515.28 CCM05485.1 - 0.071 13.0 0.0 0.42 10.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCM05485.1 - 0.44 10.8 0.0 0.44 10.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DEAD PF00270.29 CCM05486.1 - 7.6e-48 162.6 0.0 5.2e-47 159.9 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM05486.1 - 2e-23 82.8 0.0 1e-22 80.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CCM05486.1 - 3.6e-19 68.8 0.0 7.4e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CCM05486.1 - 3.2e-05 24.0 0.0 0.00011 22.3 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PIEZO PF15917.5 CCM05487.1 - 0.07 12.6 4.1 0.097 12.1 4.1 1.3 1 0 0 1 1 1 0 Piezo DUF3824 PF12868.7 CCM05487.1 - 0.28 11.8 4.9 0.53 10.9 4.9 1.5 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF3043 PF11241.8 CCM05487.1 - 6.3 6.8 12.1 3.1 7.8 7.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) TipE PF16972.5 CCM05488.1 - 0.15 11.3 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE EpuA PF11772.8 CCM05489.1 - 0.21 11.3 4.0 0.41 10.4 4.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta MFS_1 PF07690.16 CCM05490.1 - 9.6e-25 87.2 27.8 9.6e-25 87.2 27.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TIMELESS PF04821.14 CCM05491.1 - 3.1e-86 289.1 0.4 3.1e-86 289.1 0.4 1.9 2 0 0 2 2 2 1 Timeless protein TIMELESS_C PF05029.13 CCM05491.1 - 4.9e-12 45.8 0.1 4.9e-12 45.8 0.1 4.1 3 1 2 5 5 5 1 Timeless protein C terminal region SAP PF02037.27 CCM05493.1 - 3.5e-05 23.4 1.4 6.6e-05 22.6 1.4 1.5 1 0 0 1 1 1 1 SAP domain LETM1 PF07766.13 CCM05493.1 - 0.00041 19.8 0.1 0.00072 19.0 0.1 1.3 1 0 0 1 1 1 1 LETM1-like protein HNH_repeat PF18780.1 CCM05493.1 - 1 9.2 4.0 2.2 8.2 4.0 1.6 1 0 0 1 1 1 0 Homing endonuclease repeat F-box PF00646.33 CCM05496.1 - 0.005 16.7 2.5 0.0055 16.6 0.0 2.5 3 0 0 3 3 3 1 F-box domain Peptidase_S78 PF04586.17 CCM05496.1 - 0.078 13.2 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Caudovirus prohead serine protease F-box-like PF12937.7 CCM05497.1 - 0.0032 17.3 0.0 0.01 15.7 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM05497.1 - 0.065 13.1 0.2 0.41 10.6 0.2 2.3 1 1 0 1 1 1 0 F-box domain Pro-kuma_activ PF09286.11 CCM05500.1 - 6.7e-35 120.5 0.0 2.4e-34 118.7 0.0 1.9 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM05500.1 - 1e-05 25.0 2.8 2.3e-05 23.8 2.8 1.5 1 0 0 1 1 1 1 Subtilase family F-box-like PF12937.7 CCM05502.1 - 0.06 13.2 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.7 CCM05503.1 - 0.0029 17.5 0.3 0.0091 15.9 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CCM05503.1 - 0.011 15.6 0.1 0.045 13.6 0.1 2.2 1 0 0 1 1 1 0 F-box domain DivIC PF04977.15 CCM05504.1 - 0.00018 21.2 0.2 0.0005 19.8 0.2 1.8 1 1 0 1 1 1 1 Septum formation initiator LPP PF04728.13 CCM05504.1 - 0.0033 17.8 0.4 0.02 15.3 0.3 2.2 1 1 1 2 2 2 2 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 CCM05504.1 - 0.0073 16.3 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 CCM05504.1 - 0.015 14.2 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5082 PF16888.5 CCM05504.1 - 0.02 15.1 0.6 0.029 14.7 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) WEMBL PF05701.11 CCM05504.1 - 0.037 12.7 0.6 0.049 12.3 0.6 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light ADIP PF11559.8 CCM05504.1 - 0.061 13.4 0.1 0.092 12.8 0.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 CCM05504.1 - 0.076 13.1 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HALZ PF02183.18 CCM05504.1 - 0.08 13.2 0.1 0.36 11.1 0.0 1.9 2 1 1 3 3 2 0 Homeobox associated leucine zipper Atg14 PF10186.9 CCM05504.1 - 0.091 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4201 PF13870.6 CCM05504.1 - 0.11 12.2 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) LapD_MoxY_N PF16448.5 CCM05504.1 - 0.11 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 LapD/MoxY periplasmic domain ZapB PF06005.12 CCM05504.1 - 0.12 12.9 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Cell division protein ZapB FlaC_arch PF05377.11 CCM05504.1 - 0.12 12.8 0.1 6.3 7.3 0.0 2.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 CCM05504.1 - 0.15 12.4 0.0 0.53 10.6 0.0 1.9 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF4618 PF15397.6 CCM05504.1 - 0.15 11.4 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) USP8_interact PF08941.10 CCM05504.1 - 0.16 11.8 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 USP8 interacting DSPc PF00782.20 CCM05505.1 - 1e-32 112.7 0.0 1.2e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 CCM05505.1 - 0.0006 20.1 0.0 0.00084 19.6 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 CCM05505.1 - 0.013 15.1 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Rhodanese PF00581.20 CCM05505.1 - 0.057 13.9 0.0 0.12 12.9 0.0 1.5 1 1 0 1 1 1 0 Rhodanese-like domain PTPlike_phytase PF14566.6 CCM05505.1 - 0.064 13.4 0.0 0.088 12.9 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate MMR_HSR1 PF01926.23 CCM05506.1 - 0.00042 20.4 1.5 0.00051 20.1 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CCM05506.1 - 0.0028 18.1 2.3 0.024 15.0 2.3 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 CCM05506.1 - 0.0028 17.2 0.3 0.0057 16.2 0.1 1.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_23 PF13476.6 CCM05506.1 - 0.0039 17.7 0.0 0.0079 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 CCM05506.1 - 0.0061 15.9 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Septin AAA_5 PF07728.14 CCM05506.1 - 0.017 15.1 0.0 0.061 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 CCM05506.1 - 0.033 14.1 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AIG1 PF04548.16 CCM05506.1 - 0.034 13.5 0.5 0.093 12.0 0.0 1.9 2 1 0 2 2 2 0 AIG1 family T2SSE PF00437.20 CCM05506.1 - 0.043 12.9 0.0 0.12 11.4 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein GTP_EFTU PF00009.27 CCM05506.1 - 0.045 13.3 0.4 0.1 12.1 0.4 1.6 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Sigma54_activat PF00158.26 CCM05506.1 - 0.061 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain MCM PF00493.23 CCM05506.1 - 0.069 12.2 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA PF00004.29 CCM05506.1 - 0.071 13.5 0.1 0.54 10.7 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 CCM05506.1 - 0.094 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family TsaE PF02367.17 CCM05506.1 - 0.22 11.5 2.2 0.51 10.4 0.2 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CCM05506.1 - 0.7 9.6 4.1 0.34 10.6 0.1 2.5 3 0 0 3 3 3 0 AAA domain Sugar_tr PF00083.24 CCM05508.1 - 1.8e-42 145.8 14.0 6.5e-42 143.9 14.0 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM05508.1 - 2.5e-19 69.4 27.9 1.2e-10 40.9 9.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CCM05508.1 - 0.00014 21.3 0.3 0.00014 21.3 0.3 2.2 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB FMO-like PF00743.19 CCM05509.1 - 4.7e-31 107.8 0.0 3.3e-21 75.3 0.0 2.7 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCM05509.1 - 2.7e-07 30.1 0.0 2.4e-06 27.0 0.0 2.3 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM05509.1 - 2.8e-06 26.7 0.0 0.00037 19.7 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CCM05509.1 - 3.3e-05 23.3 2.4 0.00031 20.1 0.1 3.1 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM05509.1 - 0.0014 18.8 0.5 0.005 17.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CCM05509.1 - 0.0026 17.7 0.0 0.0026 17.7 0.0 3.1 4 0 0 4 4 4 1 FAD-NAD(P)-binding Thi4 PF01946.17 CCM05509.1 - 0.0062 15.8 0.2 0.98 8.6 0.0 2.2 2 0 0 2 2 2 2 Thi4 family Ras PF00071.22 CCM05510.1 - 1.1e-50 171.4 0.0 1.4e-49 167.8 0.0 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 CCM05510.1 - 1.8e-20 73.3 0.0 5.5e-20 71.8 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase O-FucT PF10250.9 CCM05510.1 - 1.3e-10 41.5 0.2 2.6e-05 24.1 0.3 3.1 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase Arf PF00025.21 CCM05510.1 - 0.00016 21.2 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CCM05510.1 - 0.064 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AKAP7_NLS PF10469.9 CCM05511.1 - 8.8e-21 74.7 0.0 8.8e-20 71.5 0.0 2.1 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Dyp_perox PF04261.12 CCM05512.1 - 0.0023 17.0 0.0 0.34 9.9 0.0 2.9 3 0 0 3 3 3 2 Dyp-type peroxidase family 4HBT PF03061.22 CCM05515.1 - 5.8e-08 33.0 0.2 1.2e-07 32.0 0.2 1.5 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 CCM05515.1 - 0.015 15.6 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 Thioesterase-like superfamily ubiquitin PF00240.23 CCM05516.1 - 9.3e-25 86.2 0.1 1e-24 86.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CCM05516.1 - 9.3e-13 47.8 0.1 1e-12 47.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 CCM05516.1 - 7.6e-05 22.6 0.0 8.4e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 CCM05516.1 - 0.0004 20.8 0.0 0.00071 20.0 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-like domain SAP18 PF06487.12 CCM05517.1 - 1.3e-29 103.2 0.3 2e-29 102.5 0.0 1.5 2 0 0 2 2 2 1 Sin3 associated polypeptide p18 (SAP18) Atrophin-1 PF03154.15 CCM05517.1 - 0.12 10.7 9.5 0.16 10.2 9.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 CCM05517.1 - 0.21 11.6 8.0 0.34 10.9 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) AIM3 PF17096.5 CCM05517.1 - 0.51 11.3 3.5 1.3 10.0 3.5 1.6 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 TAF4 PF05236.14 CCM05518.1 - 6.6e-29 101.5 4.0 6.6e-29 101.5 4.0 2.5 3 0 0 3 3 3 2 Transcription initiation factor TFIID component TAF4 family CPSF100_C PF13299.6 CCM05518.1 - 0.27 11.4 3.7 0.47 10.6 0.1 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal GRP PF07172.11 CCM05518.1 - 2.1 9.1 7.6 0.74 10.5 0.6 3.5 4 0 0 4 4 4 0 Glycine rich protein family Nucleoporin_FG PF13634.6 CCM05519.1 - 4.3e-08 33.9 158.2 13 6.7 17.0 6.7 1 1 3 4 4 4 2 Nucleoporin FG repeat region Pkinase PF00069.25 CCM05529.1 - 1.1e-51 175.7 0.0 1.5e-51 175.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05529.1 - 7.7e-29 100.7 0.0 9.8e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM05529.1 - 2.9e-06 27.4 0.0 0.0042 17.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CCM05529.1 - 0.0018 17.7 0.0 0.0046 16.3 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CCM05529.1 - 0.0098 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCM05529.1 - 0.2 11.3 0.0 0.74 9.4 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 CCM05529.1 - 0.22 11.1 0.0 0.41 10.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase 4HBT PF03061.22 CCM05530.1 - 0.00065 20.0 1.5 0.0014 18.9 1.5 1.5 1 0 0 1 1 1 1 Thioesterase superfamily Ham1p_like PF01725.16 CCM05531.1 - 1.3e-58 198.0 0.0 1.6e-58 197.8 0.0 1.0 1 0 0 1 1 1 1 Ham1 family SMC_N PF02463.19 CCM05532.1 - 1.4e-19 70.4 0.2 2.3e-19 69.7 0.2 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CCM05532.1 - 4.5e-12 46.9 28.2 4.5e-12 46.9 28.2 5.4 2 2 0 3 3 1 1 AAA domain AAA_15 PF13175.6 CCM05532.1 - 1.5e-05 24.9 0.1 1.5e-05 24.9 0.1 2.9 2 2 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 CCM05532.1 - 0.0004 20.3 9.4 0.014 15.2 0.1 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM05532.1 - 0.015 15.0 0.0 0.069 12.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain HTH_16 PF12645.7 CCM05532.1 - 0.02 14.9 0.7 0.12 12.5 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain AAA_25 PF13481.6 CCM05532.1 - 0.039 13.5 0.2 0.36 10.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 CCM05532.1 - 0.05 14.0 0.2 0.28 11.6 0.1 2.5 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.6 CCM05532.1 - 0.099 11.3 0.0 0.099 11.3 0.0 5.2 3 2 1 4 4 4 0 AAA domain ABC_tran PF00005.27 CCM05532.1 - 0.24 11.9 0.0 0.24 11.9 0.0 4.7 3 2 0 3 3 3 0 ABC transporter DUF3287 PF11690.8 CCM05532.1 - 6.9 6.4 19.2 0.97 9.2 1.2 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3287) RNase_PH PF01138.21 CCM05533.1 - 7.8e-28 97.6 0.0 1.3e-27 96.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CCM05533.1 - 9.2e-05 22.4 0.0 0.0002 21.3 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Semialdhyde_dhC PF02774.18 CCM05534.1 - 4.9e-38 131.0 0.0 7.1e-38 130.5 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CCM05534.1 - 2.9e-22 79.3 0.0 4.2e-15 56.3 0.0 2.3 2 0 0 2 2 2 2 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 CCM05534.1 - 0.13 12.9 0.0 0.37 11.5 0.0 1.8 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.20 CCM05534.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Rab5ip PF07019.12 CCM05535.1 - 5e-22 78.3 3.0 6.3e-22 78.0 3.0 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) TPR_2 PF07719.17 CCM05537.1 - 1.3e-08 34.3 2.6 0.097 12.8 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 CCM05537.1 - 1.8e-07 31.0 0.0 0.0085 16.4 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCM05537.1 - 2.5e-07 30.2 0.1 2.7 8.0 0.0 5.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCM05537.1 - 9.3e-06 25.2 0.0 0.098 12.4 0.0 3.6 2 1 1 3 3 3 1 TPR repeat TPR_10 PF13374.6 CCM05537.1 - 1.4e-05 24.8 0.9 13 5.9 0.1 6.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 CCM05537.1 - 3.7e-05 23.4 1.7 13 6.1 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM05537.1 - 0.00038 20.7 6.1 0.82 10.0 0.0 5.5 4 1 2 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 CCM05537.1 - 0.00042 20.9 4.8 0.056 14.1 0.0 5.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCM05537.1 - 0.0012 18.9 0.1 6.5 7.2 0.0 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCM05537.1 - 0.0013 18.8 0.0 0.0013 18.8 0.0 5.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 CCM05537.1 - 0.017 15.6 0.0 68 4.1 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCM05537.1 - 0.037 14.7 0.1 61 4.6 0.0 5.0 6 0 0 6 6 4 0 Tetratricopeptide repeat Rnk_N PF14760.6 CCM05537.1 - 0.084 13.4 1.3 2.1 8.9 0.1 3.0 2 0 0 2 2 2 0 Rnk N-terminus TPR_14 PF13428.6 CCM05537.1 - 0.3 12.0 14.4 4.3 8.4 0.1 6.8 6 2 2 8 8 7 0 Tetratricopeptide repeat SAM_2 PF07647.17 CCM05538.1 - 9e-13 48.1 0.0 1.5e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 CCM05538.1 - 4.3e-12 46.5 0.1 1.1e-11 45.2 0.1 1.7 1 0 0 1 1 1 1 PH domain SAM_1 PF00536.30 CCM05538.1 - 6.2e-12 45.8 0.1 1.4e-11 44.6 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 CCM05538.1 - 1.5e-11 43.9 0.2 3.4e-11 42.8 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCM05538.1 - 1.2e-09 37.6 0.5 3.4e-09 36.2 0.2 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 CCM05538.1 - 5.1e-08 32.5 0.5 1.2e-07 31.3 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SAM_3 PF18016.1 CCM05538.1 - 0.0017 18.1 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 CCM05538.1 - 0.013 15.7 0.2 0.041 14.1 0.2 1.7 1 0 0 1 1 1 0 Ste50p, sterile alpha motif SAM_PNT PF02198.16 CCM05538.1 - 0.16 12.0 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain UAF_Rrn10 PF05234.11 CCM05539.1 - 0.01 16.1 0.0 0.086 13.1 0.0 2.1 2 0 0 2 2 2 0 UAF complex subunit Rrn10 GPI PF06560.11 CCM05539.1 - 0.087 12.1 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Vfa1 PF08432.10 CCM05539.1 - 0.22 11.8 5.0 0.54 10.6 5.0 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 XRCC4 PF06632.12 CCM05539.1 - 0.3 9.9 9.9 0.67 8.7 9.9 1.5 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Presenilin PF01080.17 CCM05539.1 - 0.38 9.5 2.5 0.53 9.0 2.5 1.2 1 0 0 1 1 1 0 Presenilin Ribosomal_L13 PF00572.18 CCM05540.1 - 5.9e-52 175.2 0.0 7.3e-52 174.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 X PF00739.19 CCM05540.1 - 0.084 13.0 0.0 1.6 8.9 0.0 2.1 1 1 1 2 2 2 0 Trans-activation protein X Peptidase_M24 PF00557.24 CCM05542.1 - 8.4e-45 153.0 0.0 1e-44 152.8 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 2OG-FeII_Oxy_2 PF13532.6 CCM05543.1 - 1.9e-13 51.1 0.0 3.2e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_6 PF12697.7 CCM05546.1 - 5.3e-06 27.2 4.5 7.4e-06 26.7 4.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Asp PF00026.23 CCM05547.1 - 4.7e-66 223.4 0.3 5.6e-66 223.1 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM05547.1 - 2.6e-12 47.3 0.1 5.1e-07 30.1 0.0 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCM05547.1 - 2.7e-06 27.9 0.0 0.11 13.1 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease Syja_N PF02383.18 CCM05549.1 - 3.1e-68 230.5 0.0 4.1e-68 230.1 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Arm_3 PF16186.5 CCM05549.1 - 0.03 13.9 0.3 0.053 13.1 0.3 1.4 1 0 0 1 1 1 0 Atypical Arm repeat DUF3449 PF11931.8 CCM05550.1 - 1.3e-73 246.8 1.4 4.3e-73 245.0 0.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 CCM05550.1 - 1.5e-25 89.5 2.3 1.5e-25 89.5 0.7 1.9 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 CCM05550.1 - 1.3e-07 31.4 0.1 3e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 CCM05550.1 - 2.5e-06 27.7 6.3 1.1e-05 25.6 1.2 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CCM05550.1 - 3e-06 27.3 0.4 3e-06 27.3 0.4 2.9 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CCM05550.1 - 0.00087 19.6 1.5 0.049 14.0 0.1 2.7 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.12 CCM05550.1 - 0.054 13.6 3.6 2.8 8.1 0.1 2.9 2 0 0 2 2 2 0 DBF zinc finger DUF4484 PF14831.6 CCM05550.1 - 0.32 11.0 5.0 0.1 12.6 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) Laps PF10169.9 CCM05550.1 - 2 9.0 4.8 0.72 10.4 0.2 2.6 3 0 0 3 3 3 0 Learning-associated protein DEAD PF00270.29 CCM05551.1 - 1.5e-43 148.6 0.1 2.6e-43 147.8 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM05551.1 - 8.1e-32 109.9 0.1 3.1e-31 108.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 CCM05551.1 - 0.00023 21.5 0.1 0.013 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CCM05551.1 - 0.00086 19.3 0.0 0.0021 18.1 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CCM05551.1 - 0.042 13.6 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CCM05551.1 - 0.07 13.4 0.6 0.42 10.9 0.6 2.1 1 1 0 1 1 1 0 AAA domain tRNA-synt_1b PF00579.25 CCM05551.1 - 0.086 12.1 0.0 0.26 10.5 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) RRM_1 PF00076.22 CCM05553.1 - 3.6e-19 68.4 1.6 3.9e-19 68.2 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CCM05553.1 - 8.5e-09 35.1 0.0 9.6e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCM05553.1 - 0.082 12.8 0.1 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif RNA_pol_Rpb1_5 PF04998.17 CCM05554.1 - 2.4e-84 282.9 0.0 4.6e-84 282.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CCM05554.1 - 2.4e-63 213.3 0.0 4.5e-63 212.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CCM05554.1 - 1.4e-36 125.8 0.0 2.8e-36 124.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 CCM05554.1 - 3.8e-27 95.4 1.7 3.6e-20 72.5 0.1 3.2 3 1 0 3 3 3 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 CCM05554.1 - 6e-21 74.4 0.0 1.6e-20 73.0 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DUF4465 PF14717.6 CCM05554.1 - 0.13 12.6 0.1 0.47 10.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4465) DUF5102 PF17104.5 CCM05555.1 - 2.1e-61 208.5 0.0 2.5e-61 208.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) TPR_14 PF13428.6 CCM05556.1 - 0.04 14.7 0.6 2.4 9.2 0.1 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat RIX1 PF08167.12 CCM05557.1 - 4.8e-38 130.8 2.9 1.2e-37 129.5 2.9 1.7 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis Sec10 PF07393.11 CCM05558.1 - 1.8e-107 360.6 0.2 2.6e-107 360.0 0.2 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF1664 PF07889.12 CCM05558.1 - 0.0054 16.8 1.4 0.018 15.1 1.4 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) IFT20 PF14931.6 CCM05558.1 - 0.014 15.6 3.1 0.015 15.5 1.4 2.0 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Laminin_II PF06009.12 CCM05558.1 - 0.042 13.9 0.4 0.12 12.4 0.4 1.8 1 0 0 1 1 1 0 Laminin Domain II YtxH PF12732.7 CCM05558.1 - 0.087 13.4 0.0 5.7 7.5 0.0 3.0 2 2 0 2 2 2 0 YtxH-like protein Kin17_mid PF10357.9 CCM05558.1 - 0.24 11.3 0.0 0.24 11.3 0.0 2.4 3 0 0 3 3 3 0 Domain of Kin17 curved DNA-binding protein DUF948 PF06103.11 CCM05558.1 - 4 7.8 5.8 1.5 9.1 0.3 3.0 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Sec10 PF07393.11 CCM05559.1 - 6.6e-110 368.6 0.0 8.8e-110 368.2 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 OppC_N PF12911.7 CCM05560.1 - 0.011 15.7 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Amidohydro_2 PF04909.14 CCM05562.1 - 1.7e-19 70.7 0.0 6.5e-14 52.4 0.0 2.6 2 1 0 2 2 2 2 Amidohydrolase CP12 PF02672.15 CCM05562.1 - 0.035 14.9 0.3 0.2 12.4 0.1 2.1 1 1 1 2 2 2 0 CP12 domain TatD_DNase PF01026.21 CCM05562.1 - 0.1 12.0 0.0 0.27 10.6 0.0 1.7 2 0 0 2 2 2 0 TatD related DNase QRPTase_C PF01729.19 CCM05563.1 - 2.5e-50 170.5 0.1 3.1e-50 170.2 0.1 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 CCM05563.1 - 2.2e-19 69.3 0.1 6.4e-19 67.8 0.1 1.8 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain SBD_N PF07005.11 CCM05563.1 - 0.13 11.9 0.1 0.32 10.7 0.1 1.6 1 0 0 1 1 1 0 Sugar-binding N-terminal domain GPI-anchored PF10342.9 CCM05564.1 - 8.4e-16 58.5 5.3 8.4e-16 58.5 5.3 2.0 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SR-25 PF10500.9 CCM05564.1 - 0.93 9.1 10.0 1.8 8.1 10.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SIP1 PF04938.12 CCM05565.1 - 2.1e-25 89.7 0.0 2.6e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF3245 PF11595.8 CCM05566.1 - 4.8e-06 27.1 0.2 4.8e-06 27.1 0.2 3.2 3 1 1 4 4 4 1 Protein of unknown function (DUF3245) LZ_Tnp_IS66 PF13007.7 CCM05566.1 - 0.025 15.3 0.6 0.025 15.3 0.6 3.7 3 0 0 3 3 3 0 Transposase C of IS166 homeodomain NOP19 PF10863.8 CCM05566.1 - 0.13 12.1 0.0 0.13 12.1 0.0 3.2 4 1 0 4 4 4 0 Nucleolar protein 19 G-patch_2 PF12656.7 CCM05566.1 - 0.18 11.9 0.9 0.46 10.6 0.0 2.2 2 0 0 2 2 2 0 G-patch domain SPT6_acidic PF14632.6 CCM05566.1 - 7 7.3 17.5 5.8 7.6 0.4 4.2 4 0 0 4 4 4 0 Acidic N-terminal SPT6 Protoglobin PF11563.8 CCM05568.1 - 2.7e-36 124.8 0.0 3.4e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Protoglobin DSPc PF00782.20 CCM05569.1 - 1.1e-28 99.6 0.0 1.3e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCM05569.1 - 0.0024 17.5 0.0 0.0031 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 CCM05569.1 - 0.023 15.0 0.0 0.032 14.5 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain Tubulin PF00091.25 CCM05570.1 - 6.1e-65 219.1 0.0 1.3e-64 218.1 0.0 1.6 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCM05570.1 - 2.4e-47 160.2 0.0 4.4e-47 159.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Abhydrolase_3 PF07859.13 CCM05570.1 - 1.9e-33 116.1 0.1 1.4e-26 93.7 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCM05570.1 - 1.1e-05 24.4 0.0 4.9e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Steryl acetyl hydrolase Tubulin_3 PF14881.6 CCM05570.1 - 0.0023 17.6 0.0 0.0047 16.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Lipase_3 PF01764.25 CCM05570.1 - 0.23 11.3 0.4 17 5.2 0.0 2.9 3 0 0 3 3 3 0 Lipase (class 3) Tubulin PF00091.25 CCM05571.1 - 1.2e-54 185.5 0.0 1.9e-54 184.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CCM05571.1 - 2.7e-46 156.8 0.0 4e-46 156.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Lipase_3 PF01764.25 CCM05571.1 - 0.047 13.6 0.0 12 5.8 0.0 2.2 2 0 0 2 2 2 0 Lipase (class 3) Tubulin_2 PF13809.6 CCM05571.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.6 CCM05571.1 - 0.15 11.8 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Bin3 PF06859.12 CCM05572.1 - 4.4e-38 130.2 0.0 5.3e-38 130.0 0.0 1.1 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_25 PF13649.6 CCM05572.1 - 6.2e-05 23.6 0.0 0.00022 21.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM05572.1 - 0.00028 21.5 0.0 0.0011 19.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM05572.1 - 0.00054 20.7 0.0 0.001 19.8 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM05572.1 - 0.00093 19.0 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM05572.1 - 0.0011 18.9 0.0 0.0013 18.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CCM05572.1 - 0.0047 16.3 0.0 0.0056 16.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_PK PF05891.12 CCM05572.1 - 0.036 13.6 0.0 0.041 13.4 0.0 1.1 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase POR PF01558.18 CCM05572.1 - 0.14 12.2 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Ubie_methyltran PF01209.18 CCM05572.1 - 0.19 11.1 0.0 0.56 9.5 0.0 1.7 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family HAD_2 PF13419.6 CCM05573.1 - 1e-21 77.8 0.0 1.4e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CCM05573.1 - 1.3e-12 48.4 0.1 1.9e-10 41.4 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM05573.1 - 4.4e-08 33.1 0.0 1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CCM05573.1 - 0.0028 18.1 0.0 0.0072 16.7 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Uma2 PF05685.12 CCM05573.1 - 0.18 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative restriction endonuclease Lactamase_B_6 PF16661.5 CCM05574.1 - 2.1e-31 108.8 0.0 9.3e-31 106.8 0.0 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 CCM05574.1 - 1.7e-24 86.9 8.7 4.9e-22 78.9 0.1 4.0 3 1 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 CCM05574.1 - 7e-21 74.6 0.0 6.7e-20 71.4 0.0 2.3 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 CCM05574.1 - 1.2e-05 25.1 0.1 5.7e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain CSRNP_N PF16019.5 CCM05574.1 - 0.43 10.5 3.3 13 5.6 3.3 2.3 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus SEEEED PF14797.6 CCM05574.1 - 1.6 8.9 12.1 0.032 14.4 4.7 2.0 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex Arf PF00025.21 CCM05575.1 - 9.3e-79 262.9 0.1 1.1e-78 262.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CCM05575.1 - 1.6e-14 54.2 0.0 2.1e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CCM05575.1 - 1.8e-14 53.6 0.0 2.2e-14 53.3 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CCM05575.1 - 6.4e-13 48.6 1.2 3.9e-09 36.1 0.4 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CCM05575.1 - 1.3e-12 47.6 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CCM05575.1 - 1.6e-10 40.7 0.0 2e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CCM05575.1 - 2.5e-06 27.6 0.0 3.7e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CCM05575.1 - 0.0068 15.7 0.4 0.018 14.4 0.4 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase Sec15 PF04091.12 CCM05576.1 - 4.8e-90 302.2 1.9 4.8e-90 302.2 1.9 2.0 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like COG5 PF10392.9 CCM05576.1 - 2.8e-07 30.8 0.6 2.8e-07 30.8 0.6 3.5 3 1 1 4 4 4 1 Golgi transport complex subunit 5 Vps51 PF08700.11 CCM05576.1 - 1.3e-05 25.2 1.9 4.6e-05 23.4 0.4 2.8 2 1 0 2 2 2 1 Vps51/Vps67 Sec8_exocyst PF04048.14 CCM05576.1 - 0.00042 20.2 0.1 0.00042 20.2 0.1 2.3 2 1 0 2 2 2 1 Sec8 exocyst complex component specific domain Zw10 PF06248.13 CCM05576.1 - 0.014 14.0 3.7 0.015 13.9 0.4 2.4 2 1 2 4 4 4 0 Centromere/kinetochore Zw10 COG2 PF06148.11 CCM05576.1 - 0.028 14.5 0.8 0.028 14.5 0.8 3.0 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Ground-like PF04155.18 CCM05576.1 - 0.096 13.4 1.8 30 5.4 0.0 3.5 3 0 0 3 3 3 0 Ground-like domain ThrE PF06738.12 CCM05576.1 - 0.14 11.5 0.2 0.28 10.5 0.2 1.4 1 0 0 1 1 1 0 Putative threonine/serine exporter RAC_head PF16717.5 CCM05576.1 - 0.26 12.3 1.3 6.8 7.7 0.1 2.9 2 0 0 2 2 2 0 Ribosome-associated complex head domain Baculo_PEP_C PF04513.12 CCM05576.1 - 1.7 8.7 12.1 3.4 7.7 0.5 3.3 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus tRNA-synt_1c PF00749.21 CCM05577.1 - 7e-107 356.9 0.0 9.1e-107 356.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 CCM05577.1 - 3.7e-40 137.6 0.1 6.3e-40 136.8 0.1 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 CCM05577.1 - 1.8e-32 112.6 0.0 3.7e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 CCM05577.1 - 0.00079 20.3 2.7 0.0011 19.8 0.1 2.3 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 AAA PF00004.29 CCM05578.1 - 4.6e-22 78.9 0.0 8e-22 78.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM05578.1 - 0.0038 17.6 0.0 0.68 10.3 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CCM05578.1 - 0.023 15.0 0.1 0.16 12.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCM05578.1 - 0.05 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 CCM05578.1 - 0.14 12.5 0.0 0.37 11.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCM05578.1 - 0.16 12.2 0.0 0.5 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 CCM05578.1 - 0.18 10.9 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MAS20 PF02064.15 CCM05579.1 - 2.2e-40 137.7 0.1 4.8e-40 136.6 0.1 1.5 1 0 0 1 1 1 1 MAS20 protein import receptor SET PF00856.28 CCM05579.1 - 4.5e-10 40.2 0.0 1.5e-09 38.4 0.0 1.9 1 1 0 1 1 1 1 SET domain Nucleolin_bd PF16725.5 CCM05579.1 - 0.1 12.3 1.6 0.26 11.0 1.6 1.7 1 0 0 1 1 1 0 Nucleolin binding domain Metallothio_Pro PF02069.16 CCM05579.1 - 2.2 8.6 5.8 3.3 8.0 1.2 2.4 2 0 0 2 2 2 0 Prokaryotic metallothionein TetR_C_28 PF17937.1 CCM05581.1 - 0.093 13.2 0.1 0.33 11.5 0.1 2.0 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 CCM05582.1 - 4.5e-44 147.6 13.5 1.7e-10 41.3 0.0 6.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM05582.1 - 1e-12 48.1 0.0 0.0097 16.2 0.0 4.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CCM05582.1 - 2.4e-07 30.8 0.0 0.018 14.9 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CCM05582.1 - 1.1e-06 28.4 0.1 4 7.5 0.0 4.6 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat NACHT PF05729.12 CCM05582.1 - 1.4e-06 28.3 0.0 4.8e-06 26.6 0.0 1.9 1 1 0 1 1 1 1 NACHT domain Cytochrom_D1 PF02239.16 CCM05582.1 - 5e-05 22.0 0.1 0.0098 14.5 0.1 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 CCM05582.1 - 0.00025 20.1 0.4 3.3 6.6 0.0 4.1 2 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_16 PF13191.6 CCM05582.1 - 0.0015 18.9 0.0 0.0038 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain WD40_like PF17005.5 CCM05582.1 - 0.0026 17.1 0.0 0.041 13.2 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 CCM05582.1 - 0.037 12.7 0.1 2.5 6.6 0.0 2.9 3 1 1 4 4 4 0 Nucleoporin Nup120/160 nos_propeller PF18764.1 CCM05582.1 - 0.051 13.5 0.2 81 3.2 0.0 3.7 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat PQQ_2 PF13360.6 CCM05582.1 - 0.052 13.1 0.6 0.1 12.1 0.6 1.5 1 0 0 1 1 1 0 PQQ-like domain PQQ_3 PF13570.6 CCM05582.1 - 0.054 14.0 1.9 63 4.3 0.1 4.0 3 0 0 3 3 3 0 PQQ-like domain Proteasome_A_N PF10584.9 CCM05582.1 - 0.1 12.3 5.5 57 3.5 0.1 4.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature CHAP PF05257.16 CCM05582.1 - 0.16 12.5 4.8 11 6.7 0.0 4.4 2 1 2 4 4 4 0 CHAP domain AAA_2 PF07724.14 CCM05583.1 - 2.8e-33 115.5 0.0 1e-31 110.4 0.0 2.9 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CCM05583.1 - 1.3e-27 95.7 3.6 1e-26 92.9 0.1 2.7 1 1 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 CCM05583.1 - 6.3e-20 71.0 2.4 2.1e-19 69.3 0.2 2.7 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CCM05583.1 - 3.6e-18 66.2 0.1 2.7e-09 37.5 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCM05583.1 - 1.9e-10 40.8 0.0 5.5e-06 26.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CCM05583.1 - 1.2e-06 28.9 1.1 0.089 13.1 0.0 3.9 4 2 0 4 4 2 2 AAA domain AAA_16 PF13191.6 CCM05583.1 - 4e-06 27.3 7.3 0.0088 16.4 0.0 4.2 4 1 1 5 5 4 2 AAA ATPase domain AAA_23 PF13476.6 CCM05583.1 - 4.5e-06 27.3 2.4 0.45 11.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 CCM05583.1 - 1e-05 26.1 0.0 0.084 13.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 CCM05583.1 - 0.00015 21.8 0.0 0.3 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CCM05583.1 - 0.00025 20.6 0.0 0.023 14.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 CCM05583.1 - 0.00043 20.8 0.7 0.067 13.7 0.0 3.4 3 0 0 3 3 3 1 ABC transporter AAA_24 PF13479.6 CCM05583.1 - 0.00047 19.9 0.0 0.018 14.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CCM05583.1 - 0.00052 19.8 0.3 0.95 9.2 0.0 3.2 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 CCM05583.1 - 0.0012 18.6 0.1 0.0035 17.0 0.0 1.8 2 0 0 2 2 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 CCM05583.1 - 0.0012 18.2 0.1 0.63 9.4 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CCM05583.1 - 0.0013 19.1 0.0 1 9.8 0.0 2.9 3 0 0 3 3 2 1 RNA helicase IstB_IS21 PF01695.17 CCM05583.1 - 0.0013 18.5 0.6 0.4 10.4 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_28 PF13521.6 CCM05583.1 - 0.0062 16.8 1.2 3.1 8.0 0.0 3.3 3 1 2 5 5 3 1 AAA domain Roc PF08477.13 CCM05583.1 - 0.008 16.4 0.0 0.34 11.1 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 CCM05583.1 - 0.035 14.0 0.2 17 5.3 0.0 3.3 4 0 0 4 4 3 0 NTPase NACHT PF05729.12 CCM05583.1 - 0.051 13.5 0.0 6.7 6.6 0.0 2.6 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 CCM05583.1 - 0.053 13.4 0.1 2 8.3 0.0 2.7 3 0 0 3 3 2 0 RsgA GTPase AAA_29 PF13555.6 CCM05583.1 - 0.057 13.2 0.0 1.6 8.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CCM05583.1 - 0.063 12.5 0.1 2 7.6 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin SRP54 PF00448.22 CCM05583.1 - 0.09 12.4 0.0 0.89 9.1 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 CCM05583.1 - 0.11 12.3 6.6 17 5.2 0.0 4.5 3 2 0 4 4 4 0 ATPase domain predominantly from Archaea LCD1 PF09798.9 CCM05583.1 - 0.14 10.6 1.6 0.21 10.0 1.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein ATP_bind_1 PF03029.17 CCM05583.1 - 0.15 11.8 0.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein TsaE PF02367.17 CCM05583.1 - 0.15 12.0 0.0 5.2 7.1 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 CCM05583.1 - 0.65 9.7 3.7 16 5.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 CCM05583.1 - 0.74 9.5 4.2 14 5.3 0.0 3.6 3 1 1 4 4 3 0 AAA domain SHS2_Rpb7-N PF03876.17 CCM05584.1 - 1.6e-14 54.0 0.0 2.5e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 CCM05584.1 - 2.8e-11 43.6 0.2 5.8e-11 42.6 0.2 1.5 1 1 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 CCM05584.1 - 0.0018 18.5 0.0 0.0027 17.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Sortilin_C PF15901.5 CCM05585.1 - 4.4e-43 147.6 0.4 6.1e-43 147.1 0.4 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 PF15902.5 CCM05585.1 - 1.1e-24 87.0 0.2 1.5e-24 86.7 0.2 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 CCM05585.1 - 0.0062 16.4 0.4 2.5 8.4 0.0 3.2 2 0 0 2 2 2 1 BNR/Asp-box repeat ADAM17_MPD PF16698.5 CCM05585.1 - 0.024 15.0 1.5 0.053 13.9 1.5 1.5 1 0 0 1 1 1 0 Membrane-proximal domain, switch, for ADAM17 CHB_HEX_C PF03174.13 CCM05585.1 - 0.13 12.2 0.0 0.99 9.4 0.0 2.2 1 1 1 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Sortilin-Vps10 PF15902.5 CCM05586.1 - 2e-242 804.7 0.7 5.3e-145 483.6 0.1 2.0 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 CCM05586.1 - 4.6e-50 170.3 6.0 8e-50 169.5 6.0 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 CCM05586.1 - 2.4e-11 41.9 41.4 0.45 10.7 0.0 10.3 9 0 0 9 9 9 7 BNR/Asp-box repeat BNR_2 PF13088.6 CCM05586.1 - 3e-05 23.5 7.4 1.4 8.2 0.3 6.0 5 3 1 6 6 6 3 BNR repeat-like domain Birna_RdRp PF04197.12 CCM05586.1 - 0.035 12.4 0.0 0.051 11.9 0.0 1.1 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) Mo-co_dimer PF03404.16 CCM05586.1 - 0.061 13.3 0.1 18 5.4 0.0 4.3 5 0 0 5 5 5 0 Mo-co oxidoreductase dimerisation domain CHB_HEX_C PF03174.13 CCM05586.1 - 0.12 12.4 2.0 25 4.9 0.0 4.9 6 0 0 6 6 6 0 Chitobiase/beta-hexosaminidase C-terminal domain zf-C2H2 PF00096.26 CCM05587.1 - 3.8 8.1 13.6 5.6 7.6 1.5 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type ADH_zinc_N PF00107.26 CCM05588.1 - 6.2e-14 52.1 0.0 9.9e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM05588.1 - 0.00019 22.5 0.0 0.00032 21.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM05588.1 - 0.00049 20.0 0.0 0.0013 18.6 0.0 1.7 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Plant_vir_prot PF01307.17 CCM05588.1 - 0.054 13.7 0.0 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 Plant viral movement protein F-box-like PF12937.7 CCM05589.1 - 0.014 15.3 0.6 0.034 14.1 0.6 1.7 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 CCM05589.1 - 0.16 11.9 1.6 0.4 10.6 0.1 2.3 2 0 0 2 2 2 0 F-box domain GMC_oxred_N PF00732.19 CCM05590.1 - 6.4e-59 199.7 0.0 1e-58 199.1 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05590.1 - 2e-31 109.5 0.0 3.9e-31 108.5 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCM05590.1 - 5.2e-05 23.4 0.7 0.00012 22.2 0.7 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCM05590.1 - 0.00033 19.9 2.9 0.011 14.8 1.6 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 CCM05590.1 - 0.00046 19.9 1.8 0.0038 16.9 0.7 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CCM05590.1 - 0.00055 19.3 0.2 0.012 14.9 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM05590.1 - 0.0015 17.9 0.7 0.016 14.5 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCM05590.1 - 0.0015 17.7 0.4 0.0015 17.7 0.4 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 CCM05590.1 - 0.0087 14.8 1.5 0.021 13.6 0.1 2.1 2 1 1 3 3 3 1 HI0933-like protein Thi4 PF01946.17 CCM05590.1 - 0.064 12.5 0.1 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 CCM05590.1 - 0.097 11.5 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase dCMP_cyt_deam_1 PF00383.23 CCM05591.1 - 1.3e-16 60.3 0.2 2e-16 59.7 0.2 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 CCM05591.1 - 2.7e-09 37.3 1.5 1.8e-06 28.2 0.1 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 CCM05591.1 - 0.00045 19.9 2.0 0.13 11.8 0.1 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases ADH_N PF08240.12 CCM05591.1 - 0.014 15.2 0.1 0.022 14.6 0.1 1.3 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Phos_pyr_kin PF08543.12 CCM05591.1 - 0.13 11.6 0.3 0.23 10.8 0.1 1.4 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase FAD_binding_4 PF01565.23 CCM05592.1 - 1.7e-20 73.2 2.2 4.2e-20 71.9 2.2 1.8 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CCM05592.1 - 4.2e-08 33.1 0.2 8.6e-08 32.2 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like DnaJ PF00226.31 CCM05592.1 - 0.0081 16.3 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain GCV_T PF01571.21 CCM05594.1 - 8.4e-79 264.6 0.0 1e-78 264.3 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CCM05594.1 - 4.3e-22 77.8 0.1 8.9e-22 76.8 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain DUF1899 PF08953.11 CCM05595.1 - 7.5e-26 89.8 0.1 1.8e-25 88.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 CCM05595.1 - 2e-19 69.5 1.9 5.4e-06 27.0 0.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_4 PF16300.5 CCM05595.1 - 1.7e-16 59.8 0.3 3.4e-16 58.9 0.3 1.6 1 0 0 1 1 1 1 Type of WD40 repeat ANAPC4_WD40 PF12894.7 CCM05595.1 - 1.3e-06 28.6 0.0 0.019 15.2 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain RCC1 PF00415.18 CCM05596.1 - 7e-20 71.4 2.5 0.00023 21.7 0.0 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 CCM05596.1 - 2.4e-13 50.3 0.0 2.2e-06 27.9 0.0 3.4 2 1 1 3 3 3 2 BTB/POZ domain Ank_4 PF13637.6 CCM05596.1 - 3.6e-10 40.2 0.3 1.3e-09 38.4 0.2 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM05596.1 - 1.8e-08 34.8 0.0 5.3e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) RCC1_2 PF13540.6 CCM05596.1 - 4.1e-08 32.8 8.1 2.5e-07 30.3 0.0 5.1 6 0 0 6 6 6 1 Regulator of chromosome condensation (RCC1) repeat Ank_3 PF13606.6 CCM05596.1 - 7e-08 32.2 0.4 0.011 16.2 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 CCM05596.1 - 1.1e-06 28.7 0.9 3.2e-05 24.1 0.3 2.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 CCM05596.1 - 0.00032 21.0 0.5 0.83 10.2 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat EKLF_TAD1 PF16832.5 CCM05597.1 - 0.0022 17.8 1.2 0.0049 16.7 1.2 1.6 1 0 0 1 1 1 1 Erythroid krueppel-like transcription factor, transactivation 1 Epimerase PF01370.21 CCM05598.1 - 1.3e-14 54.3 1.1 1.1e-13 51.3 1.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM05598.1 - 2.6e-08 33.2 0.0 7.1e-08 31.8 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CCM05598.1 - 3.3e-08 33.6 0.9 6.9e-08 32.6 0.9 1.5 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CCM05598.1 - 6.1e-08 32.4 0.1 8.4e-08 32.0 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CCM05598.1 - 4.1e-07 29.8 3.1 7.7e-07 28.9 3.1 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 CCM05598.1 - 0.0064 15.7 0.2 0.17 11.0 0.0 2.1 1 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 CCM05598.1 - 0.012 14.7 0.2 0.019 14.1 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 CCM05599.1 - 4.6e-11 42.6 0.1 4e-10 39.6 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM05599.1 - 9.9e-10 38.6 0.3 1.5e-09 38.0 0.3 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCM05599.1 - 2.8e-08 33.6 0.4 1.1e-06 28.4 1.5 2.1 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CCM05599.1 - 0.0022 17.4 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCM05600.1 - 2.5e-24 85.8 0.2 8.9e-24 84.0 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05600.1 - 3.1e-17 62.9 0.6 1.4e-14 54.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05600.1 - 9.6e-08 32.1 0.1 1.6e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM05600.1 - 0.018 14.5 0.1 0.022 14.2 0.1 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 CCM05600.1 - 0.14 12.6 0.1 0.35 11.3 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Methyltransf_33 PF10017.9 CCM05601.1 - 8.9e-77 258.3 0.0 4.6e-76 255.9 0.0 1.8 1 1 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 CCM05601.1 - 2.4e-21 76.5 2.0 3e-11 43.4 0.0 2.5 3 0 0 3 3 3 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 CCM05601.1 - 0.0082 16.6 0.2 0.018 15.5 0.2 1.6 1 0 0 1 1 1 1 DinB superfamily DHHC PF01529.20 CCM05602.1 - 0.00013 22.1 5.7 0.00013 22.1 5.7 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase cIII PF08134.11 CCM05602.1 - 0.36 10.6 2.0 0.52 10.1 1.2 1.7 1 1 0 1 1 1 0 cIII protein family DNA_pol_A_exo1 PF01612.20 CCM05603.1 - 2.5e-48 164.1 0.7 3.6e-48 163.6 0.7 1.2 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 CCM05603.1 - 2.1e-12 46.9 0.0 5.6e-12 45.5 0.0 1.8 1 0 0 1 1 1 1 HRDC domain PMC2NT PF08066.12 CCM05603.1 - 0.0053 17.4 0.3 0.04 14.6 0.2 2.6 2 0 0 2 2 2 1 PMC2NT (NUC016) domain Stealth_CR2 PF11380.8 CCM05604.1 - 2e-18 66.5 0.0 6.9e-14 51.9 0.0 3.5 3 0 0 3 3 3 2 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 CCM05604.1 - 4.6e-14 52.0 0.1 1.1e-13 50.9 0.1 1.7 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 CCM05604.1 - 3.1e-05 23.6 0.0 7.2e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 CCM05604.1 - 0.00011 22.0 0.0 0.00037 20.3 0.0 2.0 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 SNF5 PF04855.12 CCM05607.1 - 4.3e-64 216.6 0.3 6.7e-64 215.9 0.3 1.3 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 DUF563 PF04577.14 CCM05607.1 - 0.026 14.7 0.0 0.18 11.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF563) TPT PF03151.16 CCM05608.1 - 8.4e-36 123.8 13.5 1.4e-35 123.0 13.5 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CCM05608.1 - 1.7e-07 30.8 16.0 4.2e-07 29.5 16.0 1.6 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 CCM05608.1 - 9e-05 22.7 28.2 0.0082 16.3 2.3 3.3 3 0 0 3 3 3 2 EamA-like transporter family zf-RING_UBOX PF13445.6 CCM05609.1 - 2.7e-07 30.5 6.5 5.9e-07 29.4 6.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCM05609.1 - 1.7e-06 27.8 3.7 1.7e-06 27.8 3.7 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCM05609.1 - 2.5e-06 27.2 3.7 2.5e-06 27.2 3.7 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCM05609.1 - 6.6e-06 25.9 6.4 6.6e-06 25.9 6.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CCM05609.1 - 8.5e-05 22.6 3.9 8.5e-05 22.6 3.9 2.8 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CCM05609.1 - 0.0002 21.2 4.7 0.0002 21.2 4.7 2.2 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCM05609.1 - 0.00037 20.8 10.3 0.0022 18.3 10.3 2.2 1 1 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 CCM05609.1 - 0.007 16.2 0.1 0.007 16.2 0.1 1.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein MAP65_ASE1 PF03999.12 CCM05609.1 - 0.4 9.3 3.8 0.56 8.8 3.8 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) zf-RING_10 PF16685.5 CCM05609.1 - 0.78 9.9 4.5 2.1 8.6 4.5 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 CCM05609.1 - 2.6 8.0 13.7 0.18 11.7 6.7 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 WH1 PF00568.23 CCM05610.1 - 2.1e-12 47.0 0.0 3.9e-11 42.9 0.0 2.0 2 0 0 2 2 2 1 WH1 domain PBD PF00786.28 CCM05610.1 - 0.00059 20.1 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Pyr_redox_2 PF07992.14 CCM05611.1 - 2.1e-45 155.2 0.0 2.5e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CCM05611.1 - 1e-11 45.2 0.0 4.5e-09 36.7 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM05611.1 - 0.16 11.2 0.2 2.8 7.1 0.1 2.4 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 CCM05612.1 - 2.4e-22 79.3 23.4 3.9e-16 58.9 18.8 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily AAA_18 PF13238.6 CCM05612.1 - 0.13 12.8 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain Polysacc_deac_1 PF01522.21 CCM05613.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 1 0 1 1 1 0 Polysaccharide deacetylase Pyridoxal_deC PF00282.19 CCM05614.1 - 3.6e-102 341.9 0.0 4.3e-102 341.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Smg4_UPF3 PF03467.15 CCM05615.1 - 3.6e-53 180.1 0.6 3.6e-53 180.1 0.6 2.5 3 1 0 3 3 3 1 Smg-4/UPF3 family DUF4121 PF13497.6 CCM05615.1 - 0.08 12.1 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) SYF2 PF08231.12 CCM05616.1 - 1.2e-61 207.8 11.0 1.2e-61 207.8 11.0 1.8 2 0 0 2 2 2 1 SYF2 splicing factor 5_nucleotid PF05761.14 CCM05616.1 - 0.031 13.2 0.6 0.031 13.2 0.6 2.3 2 1 0 2 2 2 0 5' nucleotidase family GPI-anchored PF10342.9 CCM05617.1 - 6.9e-08 33.2 1.5 6.9e-08 33.2 1.5 2.1 1 1 1 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family ORC_WH_C PF18137.1 CCM05618.1 - 2.8e-42 144.1 0.0 1.8e-41 141.5 0.0 2.2 2 0 0 2 2 2 1 Origin recognition complex winged helix C-terminal NmrA PF05368.13 CCM05618.1 - 2.1e-38 132.2 0.0 2.1e-37 128.9 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family ORC3_N PF07034.11 CCM05618.1 - 1.6e-15 57.1 3.3 2.5e-14 53.1 3.3 2.6 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus NAD_binding_10 PF13460.6 CCM05618.1 - 3e-15 56.6 0.0 5.4e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCM05618.1 - 0.00037 20.0 0.0 0.0031 17.0 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CCM05618.1 - 0.0049 15.9 0.0 0.0082 15.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GST_N PF02798.20 CCM05619.1 - 5.4e-19 68.3 0.0 9.5e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCM05619.1 - 2.1e-16 60.1 0.0 3.3e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM05619.1 - 1.1e-14 54.3 0.0 1.8e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCM05619.1 - 4.2e-11 43.0 0.0 8.5e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM05619.1 - 4.7e-05 23.3 0.0 8.7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCM05619.1 - 8.2e-05 22.7 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain UcrQ PF02939.16 CCM05620.1 - 4.8e-27 93.7 2.8 2.5e-25 88.2 2.8 2.1 1 1 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 CCM05620.1 - 0.021 15.2 0.1 0.072 13.5 0.1 2.0 1 1 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 AtpR PF12966.7 CCM05620.1 - 0.11 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 N-ATPase, AtpR subunit Melibiase_2 PF16499.5 CCM05621.1 - 1.9e-28 99.5 0.6 3e-28 98.8 0.6 1.3 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 CCM05621.1 - 1.8e-16 59.9 0.1 3.6e-16 59.0 0.1 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain SAE2 PF08573.10 CCM05622.1 - 6.1e-20 72.4 2.9 6.1e-20 72.4 2.9 3.4 5 0 0 5 5 5 1 DNA repair protein endonuclease SAE2/CtIP C-terminus TolA_bind_tri PF16331.5 CCM05622.1 - 0.025 14.6 0.8 0.025 14.6 0.8 2.6 2 0 0 2 2 2 0 TolA binding protein trimerisation ImcF-related_N PF14331.6 CCM05622.1 - 0.034 13.5 0.8 0.066 12.6 0.8 1.4 1 0 0 1 1 1 0 ImcF-related N-terminal domain ZapB PF06005.12 CCM05622.1 - 0.049 14.1 11.6 5.1 7.6 0.1 3.7 3 1 0 3 3 3 0 Cell division protein ZapB DUF4710 PF15828.5 CCM05622.1 - 0.2 11.8 1.0 0.74 10.0 1.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) Jnk-SapK_ap_N PF09744.9 CCM05622.1 - 0.52 10.5 9.0 7.1 6.8 1.8 3.2 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Mto2_bdg PF12808.7 CCM05622.1 - 1.4 9.3 6.5 1.5 9.2 1.3 3.3 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region HALZ PF02183.18 CCM05622.1 - 1.8 8.9 7.5 6.2 7.1 0.7 3.0 2 1 0 2 2 2 0 Homeobox associated leucine zipper GAS PF13851.6 CCM05622.1 - 3.9 6.8 12.2 0.11 11.9 2.8 2.8 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Cep57_CLD_2 PF14197.6 CCM05622.1 - 4.5 7.4 11.2 1.5 8.9 4.2 3.5 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 Gpi1 PF05024.15 CCM05623.1 - 6.9e-66 221.9 12.2 6.9e-66 221.9 12.2 1.8 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) F-box-like PF12937.7 CCM05624.1 - 0.045 13.6 1.0 0.11 12.4 1.0 1.7 1 0 0 1 1 1 0 F-box-like GPI-anchored PF10342.9 CCM05625.1 - 0.00012 22.7 0.2 0.00012 22.7 0.2 1.7 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family MoCF_biosynth PF00994.24 CCM05626.1 - 1.2e-33 115.8 0.0 2e-33 115.1 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain MCM PF00493.23 CCM05627.1 - 1e-98 328.9 0.0 1.6e-98 328.3 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CCM05627.1 - 3.3e-37 127.1 0.3 6e-37 126.3 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CCM05627.1 - 4.1e-29 100.8 2.5 9.4e-29 99.7 2.5 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CCM05627.1 - 2.1e-18 66.8 0.1 6.8e-18 65.2 0.1 2.0 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 CCM05627.1 - 1.8e-08 34.5 0.0 6.4e-08 32.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CCM05627.1 - 8.8e-08 31.8 0.2 4.7e-05 22.9 0.0 2.9 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CCM05627.1 - 0.00011 22.0 0.0 0.0016 18.3 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CCM05627.1 - 0.00041 20.8 0.2 0.0025 18.2 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.26 CCM05627.1 - 0.002 17.9 0.2 0.8 9.4 0.0 3.1 4 0 0 4 4 4 1 Sigma-54 interaction domain GTP1_OBG PF01018.22 CCM05628.1 - 2e-40 137.9 1.1 1.6e-29 102.5 0.3 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 CCM05628.1 - 2.4e-17 63.1 0.0 5.7e-17 61.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCM05628.1 - 0.0016 18.5 0.0 0.0079 16.3 0.0 2.1 2 0 0 2 2 2 1 Dynamin family FeoB_N PF02421.18 CCM05628.1 - 0.002 17.7 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 CCM05628.1 - 0.0066 17.0 0.0 0.016 15.7 0.0 1.8 1 0 0 1 1 1 1 ABC transporter Arf PF00025.21 CCM05628.1 - 0.0092 15.4 0.2 0.9 9.0 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family cobW PF02492.19 CCM05628.1 - 0.012 15.2 0.2 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 CCM05628.1 - 0.023 14.2 0.1 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCM05628.1 - 0.044 13.1 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 CCM05628.1 - 0.092 13.3 0.0 0.092 13.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain HLH PF00010.26 CCM05630.1 - 3.1e-06 27.0 0.3 5.8e-06 26.2 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Peptidase_S24 PF00717.23 CCM05631.1 - 2.6e-08 33.7 0.0 4.1e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Transp_cyt_pur PF02133.15 CCM05632.1 - 2.4e-30 105.7 33.9 1.1e-29 103.5 33.9 1.9 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Transp_cyt_pur PF02133.15 CCM05633.1 - 2.9e-35 121.9 30.8 1e-34 120.1 30.8 1.9 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Fungal_trans PF04082.18 CCM05634.1 - 6.5e-15 54.9 0.0 1.1e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM05634.1 - 8.3e-06 25.8 9.1 1.4e-05 25.1 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FHA PF00498.26 CCM05638.1 - 3.2e-08 33.8 0.0 7.9e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCM05638.1 - 0.00069 19.9 0.0 0.0027 18.0 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Usp PF00582.26 CCM05639.1 - 1.1e-09 39.0 0.0 1.5e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 Universal stress protein family WW PF00397.26 CCM05640.1 - 1.3e-08 34.8 6.6 4.2e-08 33.1 6.6 1.9 1 0 0 1 1 1 1 WW domain Nop53 PF07767.11 CCM05641.1 - 8.8e-95 318.4 13.5 1e-94 318.2 13.5 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Pribosyltran PF00156.27 CCM05643.1 - 8e-15 54.7 0.0 1e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCM05643.1 - 0.05 13.0 0.0 0.061 12.8 0.0 1.4 1 1 0 1 1 1 0 Uracil phosphoribosyltransferase Glyco_hydro_47 PF01532.20 CCM05644.1 - 2e-106 356.6 0.0 2.9e-106 356.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 CCM05644.1 - 2.5e-05 24.2 0.1 6.9e-05 22.8 0.1 1.7 1 0 0 1 1 1 1 PA domain Auto_anti-p27 PF06677.12 CCM05645.1 - 2.1e-26 91.8 5.6 7.2e-13 48.5 0.6 2.5 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) ORC6 PF05460.13 CCM05645.1 - 1.9 7.7 7.9 2.3 7.4 7.9 1.3 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF4658 PF15555.6 CCM05646.1 - 0.14 12.2 1.3 2 8.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4658) Sec16 PF12932.7 CCM05647.1 - 0.59 10.7 4.7 0.45 11.1 0.3 2.5 2 1 1 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region Dfp1_Him1_M PF08630.10 CCM05647.1 - 3.6 7.8 7.3 1.1 9.4 0.4 2.6 3 0 0 3 3 3 0 Dfp1/Him1, central region ABC_cobalt PF09819.9 CCM05648.1 - 0.034 14.3 2.9 0.7 10.0 0.0 2.2 1 1 1 2 2 2 0 ABC-type cobalt transport system, permease component Ribonuclease_3 PF00636.26 CCM05650.1 - 8.7e-44 148.4 0.0 1.1e-21 77.5 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CCM05650.1 - 1.9e-24 86.3 0.0 1.4e-09 38.1 0.0 4.4 4 0 0 4 4 4 4 Ribonuclease-III-like Dicer_dimer PF03368.14 CCM05650.1 - 1.7e-07 31.3 0.0 6.1e-07 29.5 0.0 2.0 1 0 0 1 1 1 1 Dicer dimerisation domain PAZ PF02170.22 CCM05650.1 - 6.4e-07 29.3 0.0 1.4e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 PAZ domain Helicase_C PF00271.31 CCM05650.1 - 0.022 15.1 0.1 0.049 14.0 0.1 1.6 1 0 0 1 1 1 0 Helicase conserved C-terminal domain COX7C PF02935.16 CCM05651.1 - 5.5e-14 52.2 0.5 6e-14 52.0 0.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc MFS_1 PF07690.16 CCM05652.1 - 4.1e-09 35.8 11.3 4.1e-09 35.8 11.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 CCM05653.1 - 4.5e-64 216.6 59.0 9.9e-39 133.2 32.4 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM05653.1 - 1.7e-09 37.1 18.1 4.2e-09 35.8 3.8 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter DUF4094 PF13334.6 CCM05653.1 - 0.46 10.9 1.6 38 4.8 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) PRCC PF10253.9 CCM05654.1 - 0.0026 18.6 1.9 0.0045 17.8 1.9 1.3 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting Ank_2 PF12796.7 CCM05655.1 - 8.8e-20 71.1 0.2 6.6e-08 33.0 0.0 3.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 CCM05655.1 - 6.1e-15 54.9 2.3 3.7e-06 27.1 0.0 4.8 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 CCM05655.1 - 2.7e-14 53.3 0.1 1.2e-08 35.3 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CCM05655.1 - 6e-10 38.5 0.1 0.0043 17.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CCM05655.1 - 6.9e-10 39.0 0.1 0.00032 20.9 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) KilA-N PF04383.13 CCM05655.1 - 0.00035 20.4 0.1 0.002 18.0 0.1 2.1 1 1 0 1 1 1 1 KilA-N domain TMF_TATA_bd PF12325.8 CCM05655.1 - 0.015 15.5 3.8 0.42 10.8 2.2 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding FOXP-CC PF16159.5 CCM05655.1 - 0.56 10.9 1.6 0.72 10.5 0.4 1.9 2 0 0 2 2 2 0 FOXP coiled-coil domain DUF724 PF05266.14 CCM05655.1 - 1 9.2 3.3 1.1 9.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Tup_N PF08581.10 CCM05655.1 - 1 9.7 3.9 5.5 7.4 0.1 2.6 2 1 0 2 2 2 0 Tup N-terminal DSPn PF14671.6 CCM05656.1 - 9.3e-42 142.8 0.0 3.1e-40 137.9 0.0 2.6 2 1 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 CCM05656.1 - 2.4e-14 53.3 0.0 4.7e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CCM05656.1 - 0.00017 21.2 0.0 0.0003 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CCM05656.1 - 0.00085 19.5 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate URO-D PF01208.17 CCM05657.1 - 2e-130 435.0 0.0 2.2e-130 434.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) COMPASS-Shg1 PF05205.12 CCM05658.1 - 3.3e-14 53.4 0.0 7.3e-14 52.3 0.0 1.6 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 MFS_1 PF07690.16 CCM05660.1 - 5.5e-31 107.8 28.2 8.3e-31 107.2 28.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily EAF PF09816.9 CCM05662.1 - 2.6e-22 79.1 0.0 8.3e-22 77.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor DUF3375 PF11855.8 CCM05662.1 - 0.28 10.1 1.5 0.53 9.1 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) Pkinase PF00069.25 CCM05665.1 - 1.6e-70 237.5 0.0 8.2e-70 235.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05665.1 - 1.9e-31 109.3 0.0 4.5e-30 104.8 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM05665.1 - 0.00028 20.3 2.4 0.97 8.7 0.2 3.3 3 0 0 3 3 3 2 Kinase-like RIO1 PF01163.22 CCM05665.1 - 0.00038 20.1 0.7 0.00067 19.3 0.7 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 CCM05665.1 - 0.033 13.0 0.4 0.058 12.2 0.4 1.5 1 1 0 1 1 1 0 Fungal protein kinase Amelin PF05111.12 CCM05665.1 - 0.55 9.3 7.9 0.86 8.7 7.9 1.2 1 0 0 1 1 1 0 Ameloblastin precursor (Amelin) Kinesin PF00225.23 CCM05667.1 - 4.5e-108 361.1 0.0 8e-108 360.3 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 CCM05667.1 - 2.7e-43 148.3 0.0 8.7e-43 146.6 0.0 2.0 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 CCM05667.1 - 9.9e-41 139.9 5.1 2.4e-32 112.5 0.9 3.0 1 1 1 2 2 2 2 Kinesin-associated Microtub_bd PF16796.5 CCM05667.1 - 3.6e-19 69.2 0.0 9.8e-19 67.8 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 CCM05667.1 - 1.3e-09 38.5 0.0 8.2e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 PH domain FHA PF00498.26 CCM05667.1 - 2.2e-06 27.9 0.0 1.3e-05 25.4 0.0 2.3 2 0 0 2 2 2 1 FHA domain KIF1B PF12423.8 CCM05667.1 - 2.6e-05 24.6 0.4 2.6e-05 24.6 0.4 2.6 3 0 0 3 3 3 1 Kinesin protein 1B PilJ PF13675.6 CCM05667.1 - 0.087 12.9 8.3 0.028 14.4 0.8 3.2 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term CaM_bdg_C0 PF10562.9 CCM05667.1 - 0.75 9.9 2.7 0.6 10.2 0.4 2.1 2 0 0 2 2 2 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit EAP30 PF04157.16 CCM05667.1 - 1.4 8.2 8.7 0.13 11.5 0.8 2.9 3 0 0 3 3 3 0 EAP30/Vps36 family S4 PF01479.25 CCM05668.1 - 5.6e-13 48.4 0.0 9.6e-13 47.6 0.0 1.3 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 CCM05668.1 - 4.2e-12 46.8 0.4 7.1e-12 46.1 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain PaaB PF06243.11 CCM05668.1 - 0.01 16.1 0.1 0.023 14.9 0.0 1.7 1 1 1 2 2 2 0 Phenylacetic acid degradation B Fe-ADH PF00465.19 CCM05669.1 - 3.9e-57 193.7 2.2 4.6e-57 193.5 2.2 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCM05669.1 - 1.6e-29 103.4 0.1 2.1e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 CCM05669.1 - 0.0007 18.8 1.1 0.45 9.6 0.1 2.3 2 0 0 2 2 2 2 3-dehydroquinate synthase PHD PF00628.29 CCM05670.1 - 6.1e-07 29.2 10.6 1.2e-06 28.3 10.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CCM05670.1 - 0.0066 16.0 9.2 0.017 14.7 9.2 1.7 1 0 0 1 1 1 1 PHD-finger Peptidase_S32 PF05579.13 CCM05671.1 - 0.061 12.5 0.2 0.19 10.9 0.1 1.7 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Aconitase PF00330.20 CCM05672.1 - 9.7e-154 512.8 0.1 1.2e-153 512.5 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCM05672.1 - 2.1e-45 154.3 0.0 4e-45 153.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Sld5 PF05916.11 CCM05675.1 - 0.0016 18.9 0.0 0.0023 18.4 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein SLD5_C PF16922.5 CCM05675.1 - 0.014 15.6 0.1 0.024 14.8 0.1 1.4 1 0 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus ThiF PF00899.21 CCM05676.1 - 6e-14 52.0 0.0 1.9e-11 43.8 0.0 2.1 2 0 0 2 2 2 2 ThiF family LysM PF01476.20 CCM05677.1 - 2.3e-14 53.1 0.0 4.6e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 LysM domain Med13_C PF06333.12 CCM05677.1 - 0.11 11.7 6.3 0.17 11.1 6.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain p450 PF00067.22 CCM05680.1 - 1.6e-14 53.6 0.0 1.6e-14 53.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM05681.1 - 3e-07 29.6 0.0 3.4e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Pro_isomerase PF00160.21 CCM05682.1 - 1.5e-44 152.1 0.0 1.7e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cir_N PF10197.9 CCM05683.1 - 2.3e-06 27.7 0.1 3.5e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of CBF1 interacting co-repressor CIR tRNA_edit PF04073.15 CCM05683.1 - 0.099 12.7 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain DUF5112 PF17139.4 CCM05683.1 - 0.27 10.7 1.1 0.34 10.4 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5112) FPN1 PF06963.12 CCM05685.1 - 1e-113 380.2 14.7 1.2e-113 380.0 14.7 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Hydrolase_6 PF13344.6 CCM05686.1 - 2.6e-24 85.2 0.0 5e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM05686.1 - 2.2e-23 82.1 0.1 5.4e-23 80.8 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 CCM05686.1 - 0.0052 17.1 0.0 2.2 8.5 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CCM05686.1 - 0.039 14.0 0.0 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Ank_4 PF13637.6 CCM05687.1 - 5.5e-17 61.9 0.9 2.5e-08 34.3 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CCM05687.1 - 2.6e-16 59.5 0.5 2.8e-08 33.8 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CCM05687.1 - 6.4e-15 55.5 0.0 4.9e-07 30.2 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CCM05687.1 - 1.2e-13 49.9 0.3 0.00038 20.7 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 CCM05687.1 - 1.4e-12 47.4 4.3 3.8e-05 23.9 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Fungal_trans PF04082.18 CCM05688.1 - 3.2e-17 62.4 0.9 5.1e-17 61.8 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 CCM05688.1 - 5.4e-05 23.4 7.2 0.0078 16.6 2.4 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 CCM05688.1 - 0.0027 18.1 3.5 0.0027 18.1 3.5 2.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM05688.1 - 0.0049 17.6 2.1 0.0049 17.6 2.1 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger DUF563 PF04577.14 CCM05689.1 - 2e-19 70.6 0.1 5.5e-18 65.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF563) MPC PF03650.13 CCM05692.1 - 5.3e-42 142.4 0.1 6.3e-42 142.2 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Suv3_C_1 PF18147.1 CCM05692.1 - 0.16 11.8 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Suv3 C-terminal domain 1 Apq12 PF12716.7 CCM05693.1 - 2.3 8.2 9.5 0.073 13.0 3.0 1.8 2 0 0 2 2 2 0 Nuclear pore assembly and biogenesis Sugar_tr PF00083.24 CCM05695.1 - 2.3e-83 280.6 25.6 1.9e-82 277.5 25.6 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM05695.1 - 2.7e-08 33.1 44.9 5.8e-08 32.0 30.6 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 CCM05696.1 - 7.7e-10 39.2 2.5 0.0075 17.1 0.0 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat Nucleos_tra2_C PF07662.13 CCM05697.1 - 1.2e-67 227.7 6.6 1.2e-67 227.7 6.6 2.1 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CCM05697.1 - 3.4e-20 72.4 7.2 3.4e-20 72.4 7.2 4.1 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus DUF1771 PF08590.10 CCM05698.1 - 4.5e-21 75.0 7.0 4.5e-21 75.0 7.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) Smr PF01713.21 CCM05698.1 - 4.5e-10 39.7 0.1 1.1e-09 38.5 0.1 1.7 1 0 0 1 1 1 1 Smr domain DnaJ PF00226.31 CCM05698.1 - 0.00034 20.7 0.0 0.00074 19.6 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain ODC_AZ PF02100.17 CCM05700.1 - 7.4e-14 51.7 0.0 1.2e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Ribosomal_S5 PF00333.20 CCM05701.1 - 1.8e-28 98.3 0.7 1.8e-28 98.3 0.7 2.2 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CCM05701.1 - 8.2e-24 82.9 0.0 1.3e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Na_H_Exchanger PF00999.21 CCM05702.1 - 5.2e-55 186.8 16.1 8.2e-55 186.1 16.1 1.3 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 CCM05702.1 - 1.2 9.3 6.3 7.7 6.7 0.1 3.2 3 0 0 3 3 3 0 YrhC-like protein CI-B14_5a PF07347.12 CCM05703.1 - 0.018 14.9 0.8 0.034 14.0 0.2 1.8 1 1 1 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) RRM_1 PF00076.22 CCM05704.1 - 2.2e-12 46.6 0.1 7.3e-05 22.5 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM05704.1 - 0.00049 20.2 0.0 0.00091 19.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif PI3_PI4_kinase PF00454.27 CCM05705.1 - 4.6e-30 105.2 0.0 1e-28 100.9 0.0 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Asp PF00026.23 CCM05706.1 - 2.3e-24 86.4 0.1 5.2e-23 81.9 0.1 2.2 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CCM05706.1 - 0.0022 18.6 0.1 3.4 8.4 0.0 2.7 2 0 0 2 2 2 2 Aspartyl protease 7TM_GPCR_Srd PF10317.9 CCM05706.1 - 0.036 13.3 0.1 0.06 12.5 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd gag-asp_proteas PF13975.6 CCM05706.1 - 0.085 13.4 0.0 3.4 8.3 0.0 2.7 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease DUF4376 PF14301.6 CCM05706.1 - 0.12 12.8 0.1 17 5.8 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4376) SLAC1 PF03595.17 CCM05707.1 - 3.5e-53 181.0 43.1 4.4e-53 180.6 43.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Peptidase_A22B PF04258.13 CCM05708.1 - 6.6e-08 32.4 0.0 8.8e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Signal peptide peptidase HCV_NS4a PF01006.20 CCM05708.1 - 0.017 14.9 0.0 0.039 13.7 0.0 1.6 1 1 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a Asp PF00026.23 CCM05709.1 - 3.6e-73 246.7 6.9 4.3e-73 246.5 6.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM05709.1 - 1.6e-08 35.0 6.6 5.8e-08 33.2 3.2 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CCM05709.1 - 0.007 16.1 0.1 0.07 12.9 0.1 2.5 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 CCM05709.1 - 0.14 12.8 0.2 11 6.8 0.2 3.1 2 1 0 2 2 2 0 Aspartyl protease GATA PF00320.27 CCM05710.1 - 4e-18 64.7 2.7 7.2e-18 63.9 2.7 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 CCM05710.1 - 1.8e-11 43.7 0.8 3.8e-11 42.6 0.8 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Sec7 PF01369.20 CCM05711.1 - 8.1e-29 100.6 0.0 1.6e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 CCM05711.1 - 8.2e-28 97.2 0.0 2e-27 95.9 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CCM05711.1 - 0.001 19.5 0.0 0.0035 17.8 0.0 1.8 1 1 0 1 1 1 1 PH domain Lzipper-MIP1 PF14389.6 CCM05711.1 - 0.11 12.8 0.4 0.57 10.5 0.4 2.3 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 CsoSCA PF08936.10 CCM05713.1 - 0.13 10.9 0.0 0.13 10.9 0.0 1.0 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase SOG2 PF10428.9 CCM05714.1 - 0.47 9.6 16.9 0.48 9.6 16.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF908 PF06012.12 CCM05714.1 - 2.9 7.2 8.9 3.3 7.0 8.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Med13_C PF06333.12 CCM05714.1 - 6.8 5.8 15.9 11 5.1 15.9 1.5 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain PSK_trans_fac PF07704.11 CCM05715.1 - 0.0056 17.4 0.4 0.14 12.9 0.0 3.1 2 0 0 2 2 2 1 Rv0623-like transcription factor CPSF73-100_C PF11718.8 CCM05716.1 - 2.7e-68 229.7 0.1 4.1e-68 229.2 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 CCM05716.1 - 8.9e-29 100.0 0.0 1.8e-28 99.0 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 CCM05716.1 - 2.8e-17 62.8 0.0 8.2e-17 61.3 0.0 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 CCM05716.1 - 6.3e-17 61.3 0.1 1.4e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 CCM05716.1 - 2.6e-16 60.2 0.6 2.6e-16 60.2 0.6 2.3 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 CCM05716.1 - 1e-06 28.8 0.1 8.6e-06 25.7 0.1 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CCM05716.1 - 2.1e-05 24.2 0.2 2.1e-05 24.2 0.2 2.3 3 0 0 3 3 3 1 Beta-lactamase superfamily domain DUF3246 PF11596.8 CCM05717.1 - 0.049 13.1 0.4 0.11 11.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) G_glu_transpept PF01019.21 CCM05719.1 - 2e-140 469.0 0.0 2.3e-140 468.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Cellulase PF00150.18 CCM05720.1 - 2.4e-25 89.5 2.3 3.5e-25 89.0 2.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 CCM05720.1 - 0.0056 15.8 0.0 0.013 14.6 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 CCM05720.1 - 0.053 12.9 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase Aminotran_4 PF01063.19 CCM05721.1 - 2.5e-21 76.5 0.0 3.7e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Amino-transferase class IV Lactamase_B PF00753.27 CCM05721.1 - 2e-18 67.1 1.2 4.1e-18 66.1 1.2 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CCM05721.1 - 0.00077 19.0 0.1 0.0015 18.1 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain SDP_N PF12278.8 CCM05722.1 - 1.1 9.4 3.8 0.4 10.8 0.4 2.0 2 0 0 2 2 2 0 Sex determination protein N terminal Inhibitor_I9 PF05922.16 CCM05723.1 - 0.058 14.1 0.1 0.2 12.3 0.1 1.9 1 1 0 1 1 1 0 Peptidase inhibitor I9 DUF5127 PF17168.4 CCM05724.1 - 3.7e-78 262.4 9.0 5e-78 262.0 9.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CCM05724.1 - 1e-32 113.2 0.5 4.9e-32 111.0 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4965) DUF4964 PF16334.5 CCM05724.1 - 4.9e-06 26.0 0.5 1.9e-05 24.1 0.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4964) Ifi-6-16 PF06140.13 CCM05725.1 - 1.1e-11 44.4 14.9 1.7e-11 43.9 14.9 1.3 1 0 0 1 1 1 1 Interferon-induced 6-16 family IMPDH PF00478.25 CCM05726.1 - 5.4e-131 436.7 0.1 1.1e-130 435.7 0.1 1.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CCM05726.1 - 1.2e-15 57.7 0.6 2.9e-08 34.1 0.0 3.0 3 0 0 3 3 3 2 CBS domain FMN_dh PF01070.18 CCM05726.1 - 9.3e-11 41.3 1.0 2.1e-10 40.2 1.0 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 CCM05726.1 - 8.3e-06 25.4 8.5 0.00013 21.5 7.5 2.5 2 1 0 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.21 CCM05726.1 - 0.00018 21.1 2.3 0.0015 18.1 2.3 2.3 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.14 CCM05726.1 - 0.0031 16.9 1.0 0.0057 16.0 1.0 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 CCM05726.1 - 0.21 11.0 1.0 1.2 8.6 0.3 2.1 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Glu_synthase PF01645.17 CCM05726.1 - 1 8.4 5.9 0.49 9.5 3.2 1.7 2 0 0 2 2 2 0 Conserved region in glutamate synthase Abhydrolase_1 PF00561.20 CCM05727.1 - 2.3e-15 56.9 0.0 3.5e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM05727.1 - 1.6e-07 32.2 0.9 2.3e-07 31.6 0.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM05727.1 - 5.9e-05 22.4 0.0 0.00011 21.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 EHN PF06441.12 CCM05727.1 - 0.032 14.6 0.8 0.094 13.1 0.0 2.1 2 1 0 2 2 2 0 Epoxide hydrolase N terminus PNP_UDP_1 PF01048.20 CCM05730.1 - 5.2e-36 124.1 0.1 1e-35 123.1 0.1 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily SH3_2 PF07653.17 CCM05731.1 - 0.00026 20.6 0.0 0.00047 19.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCM05731.1 - 0.00069 19.4 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CCM05731.1 - 0.00095 18.7 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Pkinase PF00069.25 CCM05733.1 - 5.8e-64 216.0 0.0 2.6e-63 213.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05733.1 - 3.1e-38 131.5 0.0 4.4e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM05733.1 - 5.2e-06 26.0 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCM05733.1 - 0.019 14.3 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCM05733.1 - 0.1 12.2 0.0 0.35 10.5 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CCM05733.1 - 0.19 11.6 0.2 2.2 8.1 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4551 PF15087.6 CCM05733.1 - 5.8 5.6 5.8 8 5.2 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) 2-Hacid_dh_C PF02826.19 CCM05734.1 - 5.1e-47 159.5 0.0 8.2e-47 158.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CCM05734.1 - 4.5e-20 71.7 0.0 6.5e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CCM05734.1 - 0.00012 22.3 0.0 0.00034 20.8 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 CCM05734.1 - 0.012 15.0 0.1 2.9 7.2 0.1 2.4 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 CCM05734.1 - 0.017 15.2 0.2 1.6 8.8 0.0 2.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA PF01408.22 CCM05734.1 - 0.03 15.1 0.0 0.095 13.5 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DUF5029 PF16432.5 CCM05734.1 - 0.046 13.3 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5029) F420_oxidored PF03807.17 CCM05734.1 - 0.1 13.2 0.1 0.52 10.9 0.0 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 CCM05734.1 - 0.1 13.1 0.1 0.6 10.6 0.0 2.3 3 1 0 3 3 3 0 Putative NAD(P)-binding Pkinase PF00069.25 CCM05735.1 - 8.4e-72 241.7 0.0 1.4e-71 241.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05735.1 - 9.1e-49 166.1 0.0 1.7e-48 165.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_L5_C PF00673.21 CCM05735.1 - 3.4e-23 81.6 0.0 8.2e-23 80.4 0.0 1.7 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Syntaxin_2 PF14523.6 CCM05735.1 - 1.2e-21 77.0 2.6 1.5e-20 73.5 2.0 2.5 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 CCM05735.1 - 1.7e-08 34.3 0.3 5.7e-08 32.6 0.3 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 CCM05735.1 - 5.2e-07 29.5 4.6 1.8e-06 27.8 4.6 2.0 1 1 0 1 1 1 1 Syntaxin Pkinase_fungal PF17667.1 CCM05735.1 - 0.0013 17.6 0.1 0.0028 16.5 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CCM05735.1 - 0.016 14.6 0.0 0.1 11.9 0.0 2.2 3 0 0 3 3 3 0 Kinase-like DUF4704 PF15787.5 CCM05735.1 - 0.089 12.0 3.9 2.7 7.1 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4704) Peptidase_M64 PF09471.10 CCM05737.1 - 1.2e-28 100.4 0.0 2.1e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 IgA Peptidase M64 ADH_zinc_N PF00107.26 CCM05738.1 - 4.4e-28 97.8 0.5 8.7e-28 96.9 0.3 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM05738.1 - 2e-21 77.4 0.2 3.9e-21 76.5 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM05738.1 - 6.5e-11 42.1 0.1 1.4e-09 37.8 0.0 2.7 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain HupF_HypC PF01455.18 CCM05738.1 - 0.14 12.3 0.1 0.36 11.0 0.1 1.6 1 0 0 1 1 1 0 HupF/HypC family RPAP1_C PF08620.10 CCM05739.1 - 1.9e-19 69.5 0.1 4.1e-19 68.5 0.1 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 CCM05739.1 - 6.7e-13 48.2 7.5 1.3e-12 47.3 7.5 1.5 1 0 0 1 1 1 1 RPAP1-like, N-terminal Methyltransf_25 PF13649.6 CCM05740.1 - 5e-13 49.6 0.0 2.6e-12 47.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CCM05740.1 - 4.8e-11 42.6 0.1 1.1e-10 41.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 CCM05740.1 - 9.1e-11 42.3 0.0 3.1e-10 40.6 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM05740.1 - 7.1e-10 38.9 0.0 1.7e-09 37.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM05740.1 - 9e-10 38.6 0.0 1.9e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM05740.1 - 8.6e-07 29.6 0.0 7.5e-06 26.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CCM05740.1 - 1e-05 25.2 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.16 CCM05740.1 - 1.5e-05 24.8 0.0 2.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.7 CCM05740.1 - 0.00012 22.1 0.0 0.00021 21.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 CCM05740.1 - 0.001 20.1 0.1 0.003 18.6 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CCM05740.1 - 0.0018 18.0 0.0 0.0031 17.2 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 TehB PF03848.14 CCM05740.1 - 0.0023 17.3 0.0 0.0048 16.3 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.11 CCM05740.1 - 0.0033 16.4 0.0 0.0048 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 CCM05740.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PRMT5 PF05185.16 CCM05740.1 - 0.052 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_16 PF10294.9 CCM05740.1 - 0.058 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 CCM05740.1 - 0.086 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 CCM05740.1 - 0.09 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain adh_short PF00106.25 CCM05741.1 - 1.4e-40 138.9 0.2 1.7e-40 138.6 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05741.1 - 7.8e-32 110.7 0.1 9.8e-32 110.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05741.1 - 1e-06 28.8 0.2 1.5e-06 28.2 0.2 1.2 1 0 0 1 1 1 1 KR domain WD40 PF00400.32 CCM05742.1 - 3.6e-14 52.9 1.4 6.7e-06 26.8 0.3 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat AAA_16 PF13191.6 CCM05742.1 - 2.1e-06 28.2 0.1 4.7e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CCM05742.1 - 5.1e-05 23.3 0.2 0.0002 21.3 0.2 2.0 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CCM05742.1 - 0.0029 17.9 0.0 0.0071 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Inhibitor_I66 PF16850.5 CCM05742.1 - 0.0056 16.6 0.1 0.028 14.3 0.3 2.0 2 0 0 2 2 2 1 Peptidase inhibitor I66 AAA PF00004.29 CCM05742.1 - 0.032 14.6 0.0 0.13 12.7 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 CCM05742.1 - 0.11 12.3 0.0 2.4 8.0 0.0 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase 6PF2K PF01591.18 CCM05742.1 - 0.12 11.7 0.0 0.72 9.1 0.0 2.1 2 0 0 2 2 2 0 6-phosphofructo-2-kinase RicinB_lectin_2 PF14200.6 CCM05742.1 - 0.12 13.1 0.0 0.41 11.4 0.0 2.0 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like Pyr_redox_3 PF13738.6 CCM05743.1 - 1.2e-20 74.0 0.0 1.8e-18 66.8 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM05743.1 - 2.7e-16 59.7 0.2 5.9e-13 48.7 0.3 3.0 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCM05743.1 - 9.4e-15 54.0 0.1 1.3e-13 50.2 0.1 2.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CCM05743.1 - 2.8e-11 43.2 0.1 1.3e-09 37.7 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CCM05743.1 - 1.3e-10 41.6 2.7 0.0014 19.2 0.4 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM05743.1 - 7.3e-08 32.5 0.4 7e-06 26.2 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCM05743.1 - 1.3e-06 27.9 0.3 7.9e-05 22.1 0.2 2.9 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 CCM05743.1 - 7.6e-05 21.6 0.2 0.02 13.6 0.1 2.9 4 0 0 4 4 4 1 HI0933-like protein Amino_oxidase PF01593.24 CCM05743.1 - 0.00016 21.1 0.3 0.32 10.2 0.1 3.3 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.24 CCM05743.1 - 0.00043 20.0 7.6 0.11 12.1 1.0 3.0 2 2 1 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM05743.1 - 0.00073 18.7 3.0 0.018 14.1 1.4 3.0 3 0 0 3 3 3 1 FAD binding domain NAD_binding_9 PF13454.6 CCM05743.1 - 0.001 19.1 1.0 1.6 8.7 0.1 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 CCM05743.1 - 0.0016 17.8 0.1 0.17 11.2 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SnoaL_2 PF12680.7 CCM05743.1 - 0.0094 16.6 1.1 0.42 11.3 0.1 2.5 2 0 0 2 2 2 1 SnoaL-like domain DUF4440 PF14534.6 CCM05743.1 - 0.015 15.7 0.3 0.055 13.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) FAD_oxidored PF12831.7 CCM05743.1 - 0.037 13.4 5.2 0.044 13.1 0.7 2.6 3 0 0 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCM05743.1 - 0.049 12.7 1.2 0.31 10.1 0.1 2.5 3 0 0 3 3 3 0 Lycopene cyclase protein SnoaL_3 PF13474.6 CCM05743.1 - 0.051 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain GIDA PF01134.22 CCM05743.1 - 0.47 9.5 3.6 1 8.4 0.4 2.5 2 1 0 2 2 2 0 Glucose inhibited division protein A ABC_tran PF00005.27 CCM05744.1 - 7.8e-47 159.2 0.0 6.8e-28 97.9 0.1 2.9 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CCM05744.1 - 6.3e-46 157.2 25.3 1.1e-22 81.0 0.9 3.5 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 CCM05744.1 - 4.8e-10 39.2 5.4 0.021 14.3 0.4 4.3 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CCM05744.1 - 7.7e-08 32.5 2.9 0.047 13.5 0.1 4.3 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CCM05744.1 - 5.3e-06 26.9 0.5 0.015 15.7 0.3 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CCM05744.1 - 5.6e-06 27.0 6.8 0.0011 19.5 0.1 3.7 4 0 0 4 4 4 2 AAA domain AAA_29 PF13555.6 CCM05744.1 - 4.5e-05 23.1 0.3 0.44 10.3 0.0 3.0 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CCM05744.1 - 8e-05 22.7 0.0 0.15 12.2 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_25 PF13481.6 CCM05744.1 - 0.00038 20.1 0.2 1.1 8.8 0.0 2.7 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 CCM05744.1 - 0.0035 17.1 0.1 3.1 7.5 0.0 2.9 3 0 0 3 3 3 1 IstB-like ATP binding protein DUF87 PF01935.17 CCM05744.1 - 0.0039 17.3 0.5 0.094 12.8 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 CCM05744.1 - 0.0051 16.7 0.8 2.3 8.1 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase Adeno_IVa2 PF02456.15 CCM05744.1 - 0.0057 15.5 0.2 0.27 10.0 0.0 2.5 3 0 0 3 3 3 1 Adenovirus IVa2 protein AAA_7 PF12775.7 CCM05744.1 - 0.0067 16.0 0.1 1.4 8.4 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region T2SSE PF00437.20 CCM05744.1 - 0.0073 15.4 0.3 1.6 7.8 0.1 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 CCM05744.1 - 0.013 15.8 1.5 6.9 6.9 0.5 3.2 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CCM05744.1 - 0.015 14.6 0.4 4.6 6.5 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family ResIII PF04851.15 CCM05744.1 - 0.053 13.5 0.1 8.7 6.3 0.0 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 CCM05744.1 - 0.071 13.1 0.4 30 4.6 0.0 3.5 3 1 1 4 4 4 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CCM05744.1 - 0.14 12.7 0.0 24 5.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCM05744.1 - 0.2 11.4 1.7 6.1 6.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 CCM05744.1 - 0.22 11.9 1.0 2.9 8.3 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CCM05744.1 - 0.26 11.0 2.4 1.9 8.1 0.0 2.6 3 0 0 3 3 2 0 AAA ATPase domain TMEM37 PF15108.6 CCM05744.1 - 0.66 9.8 6.3 0.1 12.5 0.6 2.4 2 0 0 2 2 2 0 Voltage-dependent calcium channel gamma-like subunit protein family Dynamin_N PF00350.23 CCM05744.1 - 2.5 8.1 6.2 11 6.1 0.0 3.3 4 0 0 4 4 3 0 Dynamin family 2OG-FeII_Oxy PF03171.20 CCM05745.1 - 1.8e-23 82.9 0.0 2.6e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCM05745.1 - 2.5e-06 28.2 0.0 4.5e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal AA_permease_2 PF13520.6 CCM05746.1 - 1.8e-60 205.0 49.3 2.2e-60 204.7 49.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CCM05746.1 - 5.9e-19 68.0 42.7 8e-19 67.6 42.7 1.2 1 0 0 1 1 1 1 Amino acid permease p450 PF00067.22 CCM05747.1 - 2.5e-64 217.7 0.0 9.4e-64 215.8 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCM05747.1 - 0.061 12.2 0.2 0.091 11.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) Peptidase_M20 PF01546.28 CCM05748.1 - 2.1e-35 122.3 0.0 2.7e-35 122.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CCM05748.1 - 6.3e-07 29.3 0.0 1.1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain ELFV_dehydrog PF00208.21 CCM05749.1 - 5.6e-54 183.4 0.0 7.7e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 CCM05749.1 - 1.6e-18 65.8 0.0 1.1e-12 46.4 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase TTSSLRR PF12468.8 CCM05752.1 - 0.013 15.7 0.1 0.018 15.3 0.1 1.3 1 0 0 1 1 1 0 Type III secretion system leucine rich repeat protein Aminotran_5 PF00266.19 CCM05754.1 - 2e-30 106.0 0.0 1e-29 103.6 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V DUF2795 PF11387.8 CCM05754.1 - 0.16 12.2 0.1 8.5 6.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) SelP_N PF04592.14 CCM05754.1 - 6.1 6.2 8.6 12 5.2 8.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region IKI3 PF04762.12 CCM05755.1 - 3.3e-234 780.0 0.0 8.4e-178 593.3 0.0 2.2 1 1 1 2 2 2 2 IKI3 family Clathrin PF00637.20 CCM05755.1 - 0.066 13.1 1.3 2.5 8.0 0.1 3.2 2 1 1 3 3 3 0 Region in Clathrin and VPS RVT_thumb PF06817.14 CCM05756.1 - 0.00092 19.0 0.2 0.0028 17.5 0.0 1.8 1 1 1 2 2 2 1 Reverse transcriptase thumb domain CBM_21 PF03370.13 CCM05758.1 - 2.1e-30 105.2 0.2 3.5e-30 104.5 0.2 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 CCM05758.1 - 1.7e-09 38.2 0.7 3.2e-09 37.2 0.7 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) DUF4718 PF15842.5 CCM05758.1 - 3.4 7.4 6.4 0.63 9.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) Pkinase PF00069.25 CCM05759.1 - 2.7e-46 158.1 0.0 7.4e-46 156.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05759.1 - 3.1e-26 92.2 0.0 3.1e-25 88.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM05759.1 - 0.088 12.1 0.0 0.26 10.6 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 CCM05759.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC2_membrane PF01061.24 CCM05760.1 - 7e-37 126.9 20.2 7e-37 126.9 20.2 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 CCM05760.1 - 3e-22 79.6 0.0 6.6e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 CCM05760.1 - 0.0035 16.5 22.9 0.0035 16.5 22.9 2.1 2 0 0 2 2 2 1 ABC-2 family transporter protein PCSK9_C3 PF18463.1 CCM05760.1 - 0.0069 16.6 3.8 0.032 14.4 3.8 2.2 1 0 0 1 1 1 1 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain RNA_polI_A34 PF08208.11 CCM05761.1 - 1.5e-24 87.3 0.2 1.5e-24 87.3 0.2 2.0 2 0 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 Ada3 PF10198.9 CCM05762.1 - 6.6e-24 84.5 0.1 6.6e-24 84.5 0.1 3.2 4 0 0 4 4 4 1 Histone acetyltransferases subunit 3 Herpes_UL25 PF01499.16 CCM05762.1 - 0.0046 15.5 1.5 0.0052 15.4 0.5 1.5 2 0 0 2 2 2 1 Herpesvirus UL25 family EH_Signature PF15611.6 CCM05762.1 - 0.52 9.7 3.0 0.33 10.3 1.3 1.5 2 0 0 2 2 2 0 EH_Signature domain Hydrolase PF00702.26 CCM05762.1 - 0.81 9.9 3.1 0.28 11.5 0.1 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase RR_TM4-6 PF06459.12 CCM05762.1 - 2.6 7.8 7.2 5.1 6.9 7.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MgtE PF01769.16 CCM05763.1 - 1.1e-30 106.6 19.6 7.4e-23 81.3 9.5 4.0 3 1 1 4 4 4 2 Divalent cation transporter Hist_deacetyl PF00850.19 CCM05764.1 - 3.9e-83 279.5 0.1 5.2e-83 279.0 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain RAP1 PF07218.11 CCM05764.1 - 9.8 4.3 5.4 14 3.8 5.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Per1 PF04080.13 CCM05765.1 - 9e-102 340.2 9.0 1.1e-101 339.9 9.0 1.1 1 0 0 1 1 1 1 Per1-like family Pribosyltran_N PF13793.6 CCM05766.1 - 6.1e-49 164.8 0.2 1.6e-48 163.5 0.1 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CCM05766.1 - 2.4e-36 125.5 0.3 2.6e-31 109.1 0.1 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CCM05766.1 - 5.8e-13 48.7 0.5 6e-12 45.4 0.2 2.5 2 1 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CCM05766.1 - 0.0037 16.7 0.1 0.0067 15.9 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase ATPgrasp_N PF18130.1 CCM05766.1 - 0.056 14.0 0.0 0.26 11.9 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp N-terminal domain AA_kinase PF00696.28 CCM05767.1 - 2.4e-41 141.9 1.4 3.4e-41 141.4 1.4 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 CCM05767.1 - 1.1e-12 47.7 0.7 1.2e-05 25.2 0.1 2.7 3 0 0 3 3 3 2 PUA domain DOPA_dioxygen PF08883.11 CCM05768.1 - 3.3e-06 27.2 0.0 0.0063 16.7 0.0 2.2 1 1 1 2 2 2 2 Dopa 4,5-dioxygenase family HET PF06985.11 CCM05770.1 - 2.7e-09 37.5 1.8 7.2e-07 29.7 0.1 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) ADK PF00406.22 CCM05771.1 - 7.5e-59 198.2 0.1 3.4e-58 196.0 0.0 2.0 2 0 0 2 2 2 1 Adenylate kinase AAA_17 PF13207.6 CCM05771.1 - 9.7e-20 71.4 0.3 2.8e-19 69.9 0.1 1.9 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 CCM05771.1 - 2.8e-16 59.2 0.8 4.6e-16 58.5 0.0 1.8 2 0 0 2 2 1 1 Adenylate kinase, active site lid Fungal_trans PF04082.18 CCM05771.1 - 2.1e-09 36.8 0.2 4.7e-09 35.7 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM05771.1 - 0.00016 21.8 3.2 0.00036 20.6 3.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_18 PF13238.6 CCM05771.1 - 0.009 16.6 0.0 0.024 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATF7IP_BD PF16788.5 CCM05771.1 - 0.04 14.0 0.3 6.3 6.8 0.1 2.2 2 0 0 2 2 2 0 ATF-interacting protein binding domain FlxA PF14282.6 CCM05771.1 - 0.045 13.7 0.1 0.045 13.7 0.1 2.9 3 0 0 3 3 2 0 FlxA-like protein AAA_33 PF13671.6 CCM05771.1 - 0.11 12.6 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran_CTD PF16326.5 CCM05771.1 - 0.27 11.5 1.7 12 6.2 0.1 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain Allexi_40kDa PF05549.11 CCM05771.1 - 0.68 9.4 3.7 0.23 11.0 0.6 1.7 2 0 0 2 2 2 0 Allexivirus 40kDa protein PAP1 PF08601.10 CCM05771.1 - 2.2 7.9 10.1 3.4 7.3 10.1 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 TMF_DNA_bd PF12329.8 CCM05771.1 - 3.9 7.5 5.6 6.5 6.8 0.4 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DDOST_48kD PF03345.14 CCM05772.1 - 9.1e-129 429.9 0.0 1.1e-128 429.6 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta V_ATPase_I PF01496.19 CCM05773.1 - 0 1051.9 0.0 0 1051.7 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family ABC_tran PF00005.27 CCM05774.1 - 5.4e-43 146.8 0.0 1.7e-20 73.9 0.0 3.8 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CCM05774.1 - 5.3e-18 65.9 1.0 5.4e-07 29.7 0.3 4.6 2 2 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCM05774.1 - 5.5e-13 48.9 0.4 0.0022 17.5 0.0 4.2 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CCM05774.1 - 1.1e-07 31.4 0.1 0.015 15.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CCM05774.1 - 1.7e-06 28.4 0.0 0.097 12.9 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 CCM05774.1 - 1.8e-06 28.6 6.8 0.015 15.8 0.0 3.2 3 1 0 3 3 3 2 AAA domain DUF87 PF01935.17 CCM05774.1 - 3.6e-06 27.2 0.0 0.0031 17.6 0.0 3.3 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_16 PF13191.6 CCM05774.1 - 9.3e-06 26.1 0.2 0.0064 16.9 0.0 3.4 4 0 0 4 4 3 1 AAA ATPase domain HEAT_2 PF13646.6 CCM05774.1 - 1.9e-05 25.0 14.9 0.0033 17.8 0.4 4.6 3 1 1 4 4 4 1 HEAT repeats MMR_HSR1 PF01926.23 CCM05774.1 - 2e-05 24.6 0.0 0.11 12.6 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 CCM05774.1 - 5.3e-05 23.8 0.1 0.028 15.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CCM05774.1 - 5.6e-05 23.1 0.1 0.12 12.3 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase Chromo PF00385.24 CCM05774.1 - 7.6e-05 22.5 0.1 0.00019 21.3 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RNA_helicase PF00910.22 CCM05774.1 - 0.00014 22.2 0.0 0.36 11.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA PF00004.29 CCM05774.1 - 0.0002 21.8 0.0 3.6 8.0 0.0 4.1 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CCM05774.1 - 0.00055 19.9 0.2 0.48 10.3 0.0 2.8 2 1 0 2 2 2 1 NACHT domain MeaB PF03308.16 CCM05774.1 - 0.00071 18.6 0.3 0.32 9.9 0.1 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 CCM05774.1 - 0.00072 19.5 0.2 4.5 7.1 0.0 3.6 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 CCM05774.1 - 0.0011 19.3 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CCM05774.1 - 0.0012 18.7 4.6 0.26 10.9 0.0 3.4 4 1 0 4 4 3 2 AAA ATPase domain AAA_33 PF13671.6 CCM05774.1 - 0.0012 19.0 0.0 1.3 9.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CCM05774.1 - 0.0031 17.1 0.1 2 7.9 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_30 PF13604.6 CCM05774.1 - 0.0034 17.1 0.2 3.4 7.3 0.1 3.3 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 CCM05774.1 - 0.0035 17.6 0.1 1.1 9.6 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 CCM05774.1 - 0.011 15.4 0.0 2.4 7.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CCM05774.1 - 0.012 14.8 0.1 3.8 6.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_13 PF13166.6 CCM05774.1 - 0.016 13.9 0.0 1.7 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CCM05774.1 - 0.016 14.4 0.0 2.5 7.2 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain HEAT_EZ PF13513.6 CCM05774.1 - 0.038 14.5 11.4 3.3 8.3 1.7 4.9 5 0 0 5 5 4 0 HEAT-like repeat HEAT PF02985.22 CCM05774.1 - 0.047 14.0 10.8 2.7 8.5 0.0 5.8 7 0 0 7 7 4 0 HEAT repeat NTPase_1 PF03266.15 CCM05774.1 - 0.047 13.6 0.1 5.6 6.9 0.0 2.6 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 CCM05774.1 - 0.054 13.5 0.7 13 5.8 0.0 2.9 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CCM05774.1 - 0.058 13.6 0.0 17 5.6 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase 4HB PF17947.1 CCM05774.1 - 0.064 13.3 0.0 0.26 11.4 0.0 2.0 1 0 0 1 1 1 0 Four helical bundle domain CLP1_P PF16575.5 CCM05774.1 - 0.069 12.9 0.1 19 4.9 0.0 2.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop FtsK_SpoIIIE PF01580.18 CCM05774.1 - 0.081 12.3 0.1 2.5 7.4 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_14 PF13173.6 CCM05774.1 - 0.084 12.9 0.0 7.6 6.6 0.0 3.2 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 CCM05774.1 - 0.11 12.0 0.6 18 4.8 0.1 3.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain KAP_NTPase PF07693.14 CCM05774.1 - 0.12 11.6 0.1 0.57 9.4 0.0 2.1 2 0 0 2 2 2 0 KAP family P-loop domain Dynamin_N PF00350.23 CCM05774.1 - 0.14 12.2 0.0 2.2 8.3 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_5 PF07728.14 CCM05774.1 - 0.25 11.3 4.6 18 5.3 0.1 4.3 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) Peptidase_M50B PF13398.6 CCM05775.1 - 1.8e-48 164.9 14.3 2.5e-48 164.4 14.3 1.2 1 0 0 1 1 1 1 Peptidase M50B-like DUF92 PF01940.16 CCM05775.1 - 0.53 9.7 6.3 2.4 7.5 3.0 2.4 2 0 0 2 2 2 0 Integral membrane protein DUF92 Ndc1_Nup PF09531.10 CCM05775.1 - 0.97 8.0 4.9 1.3 7.6 4.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ras PF00071.22 CCM05777.1 - 2.6e-56 189.7 2.2 3e-52 176.5 0.2 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CCM05777.1 - 1.4e-29 102.7 0.3 8.4e-25 87.3 0.1 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM05777.1 - 3.8e-08 33.0 0.1 5.4e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM05777.1 - 0.00024 20.7 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM05777.1 - 0.014 15.3 0.1 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 CCM05777.1 - 0.02 15.0 0.5 0.32 11.1 0.5 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase rhaM PF05336.13 CCM05778.1 - 1.2e-32 112.2 0.1 1.3e-32 112.0 0.1 1.0 1 0 0 1 1 1 1 L-rhamnose mutarotase MA3 PF02847.17 CCM05779.1 - 8e-27 93.5 0.2 1.9e-26 92.2 0.2 1.7 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 CCM05779.1 - 1.1e-12 48.1 1.5 3.9e-12 46.3 0.0 2.3 2 0 0 2 2 2 1 MIF4G domain BLACT_WH PF17778.1 CCM05780.1 - 2.4e-14 53.0 0.0 3.9e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 CCM05780.1 - 0.0036 17.3 0.4 0.0063 16.5 0.4 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily VCBS PF13517.6 CCM05781.1 - 4.1e-26 91.4 16.1 3.3e-08 34.0 1.3 5.8 4 1 2 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CCM05781.1 - 2.4e-09 37.1 16.7 0.14 12.3 0.0 6.9 7 0 0 7 7 7 3 FG-GAP repeat TcdB_toxin_midN PF12256.8 CCM05781.1 - 0.0067 15.8 6.3 5.9 6.2 0.0 5.6 4 1 2 6 6 6 1 Insecticide toxin TcdB middle/N-terminal region Itfg2 PF15907.5 CCM05781.1 - 0.0068 15.5 0.0 0.18 10.8 0.0 2.7 3 0 0 3 3 3 1 Integrin-alpha FG-GAP repeat-containing protein 2 Ras PF00071.22 CCM05783.1 - 5.4e-54 182.1 0.0 6.2e-54 182.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM05783.1 - 2.6e-19 69.6 0.0 3.7e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM05783.1 - 2.7e-07 30.2 0.0 3.6e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM05783.1 - 0.047 13.2 0.0 0.32 10.5 0.0 2.1 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain PET117 PF15786.5 CCM05783.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial Rnk_N PF14760.6 CCM05783.1 - 0.27 11.7 1.0 1.6 9.3 0.1 2.1 2 0 0 2 2 2 0 Rnk N-terminus DUF1077 PF06417.12 CCM05784.1 - 1.7e-22 79.6 0.1 2e-22 79.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Piwi PF02171.17 CCM05785.1 - 1.3e-67 228.2 0.0 2.7e-67 227.1 0.0 1.6 1 0 0 1 1 1 1 Piwi domain ArgoL1 PF08699.10 CCM05785.1 - 2.8e-16 58.9 0.1 9e-16 57.3 0.1 1.9 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 CCM05785.1 - 9.8e-11 42.4 0.0 1.7e-09 38.4 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL2 PF16488.5 CCM05785.1 - 2.4e-09 37.4 0.0 6.8e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 CCM05785.1 - 1.3e-06 28.6 0.0 3.9e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Mid domain of argonaute ORC2 PF04084.14 CCM05786.1 - 1e-84 284.3 0.0 1.2e-84 284.0 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 SIR2_2 PF13289.6 CCM05786.1 - 0.098 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 SIR2-like domain HET PF06985.11 CCM05787.1 - 3.7e-26 92.2 0.0 7.5e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Baculo_DNA_bind PF04786.12 CCM05787.1 - 0.038 13.4 0.1 0.064 12.6 0.1 1.2 1 0 0 1 1 1 0 ssDNA binding protein zf_UBZ PF18439.1 CCM05788.1 - 0.053 13.1 1.4 7.5 6.2 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cwf_Cwc_15 PF04889.12 CCM05788.1 - 0.47 10.2 3.4 0.77 9.5 3.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-C2H2_4 PF13894.6 CCM05788.1 - 1.8 9.6 4.3 7.3 7.7 1.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger Peptidase_S10 PF00450.22 CCM05789.1 - 1.1e-100 338.1 0.0 1.3e-100 337.7 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase tRNA-synt_1b PF00579.25 CCM05790.1 - 7.1e-16 58.4 0.0 2.8e-15 56.4 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Lipase_GDSL_2 PF13472.6 CCM05791.1 - 3.5e-08 34.1 0.0 7.4e-08 33.0 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCM05791.1 - 0.00013 22.0 0.0 0.0012 18.9 0.0 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CE2_N PF17996.1 CCM05791.1 - 0.0081 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Rad1 PF02144.16 CCM05792.1 - 4.8e-72 242.3 0.0 6.7e-72 241.8 0.0 1.2 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 PI-PLC-X PF00388.19 CCM05793.1 - 0.00059 19.4 0.0 0.00091 18.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Lysine_decarbox PF03641.14 CCM05794.1 - 6.3e-29 100.7 0.0 8.8e-29 100.3 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CCM05794.1 - 1.3e-07 31.4 1.1 2.6e-07 30.4 1.1 1.5 1 1 0 1 1 1 1 SLOG cluster4 family Hemerythrin PF01814.23 CCM05798.1 - 3.5e-08 34.1 9.5 3.5e-08 34.1 9.5 1.5 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain BTB PF00651.31 CCM05799.1 - 2.5e-06 27.7 0.0 8e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain DUF2889 PF11136.8 CCM05799.1 - 0.089 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2889) Acyl-CoA_dh_1 PF00441.24 CCM05800.1 - 0.00031 21.0 0.0 0.00059 20.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CCM05800.1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain p450 PF00067.22 CCM05801.1 - 1.7e-55 188.6 0.2 2.4e-55 188.1 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 Kelch_5 PF13854.6 CCM05802.1 - 2.1e-14 53.1 0.6 0.00037 20.4 0.0 4.0 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 CCM05802.1 - 2.5e-12 46.3 0.6 0.0016 18.3 0.0 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 CCM05802.1 - 5.2e-12 45.6 1.4 0.0012 18.8 0.0 4.8 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 CCM05802.1 - 8e-12 44.6 0.0 0.0036 16.8 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 CCM05802.1 - 4e-11 42.8 0.7 0.015 15.6 0.0 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 CCM05802.1 - 1e-10 41.6 0.1 5.8e-06 26.5 0.0 4.5 4 0 0 4 4 4 2 Galactose oxidase, central domain RAG2 PF03089.14 CCM05802.1 - 0.1 11.6 0.0 0.23 10.4 0.0 1.5 1 1 0 1 1 1 0 Recombination activating protein 2 BTB PF00651.31 CCM05802.1 - 0.14 12.3 0.1 1.9 8.7 0.1 2.5 1 1 0 1 1 1 0 BTB/POZ domain DUF2828 PF11443.8 CCM05803.1 - 1.3e-206 687.6 0.2 5.5e-206 685.5 0.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF2828) DUF5422 PF17459.2 CCM05804.1 - 0.42 10.8 5.5 0.17 12.1 2.2 2.0 1 1 0 2 2 2 0 Family of unknown function (DUF5422) FixS PF03597.15 CCM05804.1 - 1.6 8.5 5.2 3.9 7.2 4.1 2.3 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type Pro_CA PF00484.19 CCM05805.1 - 3e-36 125.0 0.1 4.2e-36 124.6 0.1 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Isochorismatase PF00857.20 CCM05805.1 - 0.0067 16.6 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family PMI_typeI PF01238.21 CCM05807.1 - 1.9e-74 251.1 0.0 2.3e-74 250.8 0.0 1.1 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 CCM05807.1 - 2.4e-05 23.9 0.4 0.0042 16.8 0.2 2.5 2 0 0 2 2 2 2 Cupin domain Beta-lactamase PF00144.24 CCM05808.1 - 5.5e-20 71.9 0.1 7.1e-16 58.3 0.0 2.3 1 1 1 2 2 2 2 Beta-lactamase p450 PF00067.22 CCM05809.1 - 2.8e-39 135.1 0.0 3.5e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DPBB_1 PF03330.18 CCM05810.1 - 0.048 14.0 0.1 0.96 9.8 0.0 2.2 2 1 0 2 2 2 0 Lytic transglycolase HalOD2 PF18547.1 CCM05810.1 - 0.052 13.4 1.1 9.5 6.2 1.1 2.3 2 0 0 2 2 2 0 Halobacterial output domain 2 BTB PF00651.31 CCM05812.1 - 1.7e-05 25.0 0.1 0.016 15.4 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain Pkinase_Tyr PF07714.17 CCM05813.1 - 2.3e-51 174.6 0.0 3.5e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM05813.1 - 7.6e-37 127.1 0.0 1.5e-36 126.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 CCM05813.1 - 0.003 16.9 0.0 0.0064 15.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM05813.1 - 0.014 15.0 0.0 0.042 13.4 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Kinase-like PF14531.6 CCM05813.1 - 0.033 13.5 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like LRR_4 PF12799.7 CCM05815.1 - 0.037 14.5 10.7 0.97 10.0 0.0 4.8 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) HalOD2 PF18547.1 CCM05816.1 - 0.046 13.6 1.2 8.2 6.4 1.2 2.3 2 0 0 2 2 2 0 Halobacterial output domain 2 DPBB_1 PF03330.18 CCM05816.1 - 0.12 12.7 0.2 2.3 8.5 0.0 2.2 2 1 0 2 2 2 0 Lytic transglycolase 4HBT_2 PF13279.6 CCM05817.1 - 0.17 12.4 0.0 0.24 11.9 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily RhoGEF67_u1 PF16615.5 CCM05817.1 - 9.1 6.9 11.9 20 5.8 0.5 2.4 2 0 0 2 2 2 0 Unstructured region one on RhoGEF 6 and 7 zf-MYND PF01753.18 CCM05818.1 - 1.3e-11 44.4 16.9 2.1e-11 43.7 14.4 2.1 2 0 0 2 2 2 1 MYND finger Ank_2 PF12796.7 CCM05818.1 - 2.6e-06 27.9 0.1 5.4e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM05818.1 - 3.2e-06 27.3 0.1 2.1e-05 24.7 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCM05818.1 - 0.0014 19.1 0.1 0.04 14.5 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CCM05818.1 - 0.0044 17.4 0.4 7.3 7.2 0.2 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ecl1 PF12855.7 CCM05818.1 - 0.0061 17.7 1.9 0.0093 17.1 1.9 1.3 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-HIT PF04438.16 CCM05818.1 - 2.1 8.3 12.1 0.13 12.1 6.7 1.8 2 0 0 2 2 2 0 HIT zinc finger zf-C6H2 PF15801.5 CCM05818.1 - 3.6 8.0 11.0 6.9 7.1 11.0 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Ank_2 PF12796.7 CCM05821.1 - 4e-30 104.2 0.5 3.9e-14 53.0 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CCM05821.1 - 6.6e-25 86.9 5.8 4.7e-11 42.7 0.2 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CCM05821.1 - 7.2e-25 87.0 2.9 8.8e-07 29.4 0.1 5.6 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 CCM05821.1 - 2.6e-23 81.4 3.5 2.8e-05 24.3 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 CCM05821.1 - 2.9e-21 73.3 3.1 0.00018 21.7 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat GPI-anchored PF10342.9 CCM05821.1 - 0.075 13.8 0.1 21 6.0 0.0 3.0 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family NAD_binding_10 PF13460.6 CCM05823.1 - 8.5e-09 35.6 0.2 1.3e-08 34.9 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCM05823.1 - 6.9e-07 29.1 0.0 1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCM05823.1 - 1e-06 28.4 0.1 0.0046 16.5 0.1 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CCM05823.1 - 2e-05 25.0 0.0 3.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CCM05823.1 - 0.00038 20.5 0.0 0.00063 19.8 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 CCM05823.1 - 0.0062 15.7 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein F420_oxidored PF03807.17 CCM05823.1 - 0.025 15.1 0.0 0.049 14.2 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 CCM05823.1 - 0.061 12.5 0.0 0.096 11.8 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CCM05823.1 - 0.097 11.7 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DXP_reductoisom PF02670.16 CCM05823.1 - 0.16 12.7 0.0 0.25 12.0 0.0 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase NAD_binding_10 PF13460.6 CCM05824.1 - 6.2e-10 39.3 0.3 1.8e-09 37.8 0.2 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 CCM05824.1 - 4.7e-07 29.6 0.1 7.2e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 CCM05824.1 - 2.8e-05 24.4 0.1 5.1e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CCM05824.1 - 4.1e-05 24.0 0.0 8.1e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CCM05824.1 - 4.3e-05 23.1 0.1 0.00057 19.4 0.1 2.3 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCM05824.1 - 0.00019 20.7 0.0 0.00034 19.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Shikimate_DH PF01488.20 CCM05824.1 - 0.0015 18.6 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCM05824.1 - 0.0085 16.7 0.0 0.025 15.1 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 CCM05824.1 - 0.038 13.0 0.0 0.073 12.1 0.0 1.5 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CCM05824.1 - 0.16 11.1 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CCM05825.1 - 1.6e-08 34.7 0.2 2.4e-08 34.1 0.2 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCM05825.1 - 6.9e-06 25.8 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 CCM05825.1 - 4.1e-05 24.0 0.0 7.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CCM05825.1 - 0.0002 20.9 0.0 0.014 14.9 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CCM05825.1 - 0.00035 19.8 0.0 0.00053 19.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 CCM05825.1 - 0.0007 19.9 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CCM05825.1 - 0.0027 17.8 0.1 0.006 16.6 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CCM05825.1 - 0.015 15.9 0.0 0.03 14.9 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 CCM05825.1 - 0.068 12.6 0.0 2.3 7.5 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCM05825.1 - 0.18 10.8 0.0 0.31 10.0 0.0 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family LRR_8 PF13855.6 CCM05826.1 - 0.031 14.0 0.2 21 5.0 0.0 4.1 4 0 0 4 4 4 0 Leucine rich repeat Glyco_hydro_16 PF00722.21 CCM05827.1 - 0.00037 20.0 0.1 0.00077 19.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Zn_clus PF00172.18 CCM05828.1 - 0.011 15.9 13.3 0.016 15.3 13.3 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MAM33 PF02330.16 CCM05829.1 - 1.5e-61 208.0 6.7 6.2e-59 199.5 2.3 2.0 2 0 0 2 2 2 2 Mitochondrial glycoprotein Lipocalin PF00061.23 CCM05829.1 - 0.12 12.6 0.1 21 5.3 0.0 2.3 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family RRM_1 PF00076.22 CCM05831.1 - 1.8e-47 159.0 0.0 1.1e-15 57.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CCM05831.1 - 0.0057 16.7 0.0 0.22 11.6 0.0 3.0 3 0 0 3 3 3 1 Limkain b1 RRM_5 PF13893.6 CCM05831.1 - 0.0074 15.9 0.0 1.1 8.8 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3343 PF11823.8 CCM05831.1 - 0.042 13.3 0.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) DUF4707 PF15806.5 CCM05831.1 - 0.75 8.7 7.5 1 8.2 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4707) Apt1 PF10351.9 CCM05831.1 - 3.2 6.5 15.0 5.2 5.8 15.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Glyco_transf_20 PF00982.21 CCM05832.1 - 5.8e-94 315.4 0.3 1.1e-75 255.2 0.0 2.3 2 1 1 3 3 3 2 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CCM05832.1 - 4.9e-69 232.0 0.0 1.5e-68 230.4 0.0 1.7 2 0 0 2 2 2 1 Trehalose-phosphatase His_Phos_2 PF00328.22 CCM05833.1 - 1.1e-46 159.9 0.0 1.4e-46 159.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DNApol_Exo PF18136.1 CCM05834.1 - 5.6e-78 261.9 0.0 1.2e-77 260.8 0.0 1.5 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 CCM05834.1 - 4.2e-47 161.0 0.0 1.4e-46 159.3 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase family A MqsR_toxin PF15723.5 CCM05834.1 - 0.15 12.4 0.2 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 Motility quorum-sensing regulator, toxin of MqsA Cellulase PF00150.18 CCM05837.1 - 2e-14 53.7 0.0 3.6e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF1590 PF07629.11 CCM05837.1 - 2 8.3 5.1 1.5 8.7 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1590) F-box-like PF12937.7 CCM05838.1 - 3.5e-08 33.2 0.1 1.1e-07 31.6 0.1 2.0 1 0 0 1 1 1 1 F-box-like Arrestin_N PF00339.29 CCM05839.1 - 1.8e-10 41.1 0.4 2.2e-08 34.3 0.0 2.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CCM05839.1 - 1.8e-06 28.5 0.0 0.013 16.0 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 CCM05839.1 - 0.012 14.9 0.1 1 8.4 0.0 2.7 3 0 0 3 3 3 0 Rgp1 Arrestin_C PF02752.22 CCM05840.1 - 1.2e-07 32.2 0.1 0.0016 18.9 0.1 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CCM05840.1 - 1.4e-05 25.2 0.1 0.0042 17.2 0.0 3.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 CCM05840.1 - 0.02 14.1 0.5 0.44 9.7 0.1 2.3 2 0 0 2 2 2 0 Rgp1 adh_short PF00106.25 CCM05842.1 - 7e-11 41.9 0.0 1.4e-10 40.9 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05842.1 - 4.5e-08 32.9 0.0 8.3e-08 32.1 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05842.1 - 1.1e-05 25.4 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCM05842.1 - 0.00094 19.4 0.0 0.0018 18.6 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 CCM05843.1 - 1.1e-12 47.9 0.0 2.5e-12 46.6 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05843.1 - 2.5e-09 37.0 0.0 4e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05843.1 - 1.1e-06 28.7 0.0 1.7e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCM05843.1 - 0.015 15.5 0.0 0.025 14.8 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Peptidase_C14 PF00656.22 CCM05844.1 - 6.8e-36 124.5 0.0 9.4e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Fe_hyd_lg_C PF02906.14 CCM05844.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain adh_short PF00106.25 CCM05845.1 - 2e-10 40.5 0.0 6.1e-10 38.9 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05845.1 - 1.3e-06 28.2 0.0 2.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05845.1 - 4.3e-06 26.8 0.0 6.3e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CCM05845.1 - 0.0094 16.2 0.1 0.014 15.6 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF3128 PF11326.8 CCM05846.1 - 0.21 12.0 0.0 0.41 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3128) Ctr PF04145.15 CCM05847.1 - 4.7e-10 40.3 4.8 5.4e-10 40.1 4.8 1.2 1 1 0 1 1 1 1 Ctr copper transporter family DUF4310 PF14187.6 CCM05847.1 - 0.0072 16.0 0.1 0.0096 15.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4310) MU2_FHA PF18221.1 CCM05850.1 - 0.069 13.2 0.0 0.087 12.9 0.0 1.2 1 0 0 1 1 1 0 Mutator 2 Fork head associated domain SMP PF04927.12 CCM05851.1 - 0.083 13.4 0.1 0.13 12.8 0.1 1.3 1 0 0 1 1 1 0 Seed maturation protein Peptidase_C14 PF00656.22 CCM05852.1 - 6.9e-31 108.1 0.1 1e-30 107.5 0.1 1.2 1 0 0 1 1 1 1 Caspase domain adh_short PF00106.25 CCM05853.1 - 4.7e-11 42.5 0.0 1.4e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05853.1 - 9e-07 28.7 0.0 1.9e-06 27.6 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05853.1 - 5.4e-06 26.4 0.0 7.9e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF3842 PF12953.7 CCM05853.1 - 0.18 12.2 0.0 0.25 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) WD40 PF00400.32 CCM05854.1 - 1.5e-14 54.1 5.5 6.1e-06 26.9 0.3 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM05854.1 - 7.1e-05 23.0 0.1 0.053 13.8 0.0 3.2 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1961 PF09224.11 CCM05854.1 - 0.0011 18.4 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1961) Nucleoporin_N PF08801.11 CCM05854.1 - 0.022 13.5 0.2 0.067 11.9 0.1 1.7 2 1 0 2 2 2 0 Nup133 N terminal like BBS2_Mid PF14783.6 CCM05854.1 - 0.15 12.2 0.0 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region AA_permease_2 PF13520.6 CCM05855.1 - 9.6e-60 202.6 42.3 1.3e-49 169.2 33.1 2.1 1 1 1 2 2 2 2 Amino acid permease HMG_box PF00505.19 CCM05857.1 - 4.8e-09 36.5 7.8 2.6e-08 34.2 7.8 2.1 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM05857.1 - 7.8e-09 36.0 3.7 1.9e-08 34.8 3.7 1.6 1 0 0 1 1 1 1 HMG-box domain Pkinase PF00069.25 CCM05860.1 - 3.3e-45 154.5 0.0 4.4e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05860.1 - 2.1e-27 96.1 0.0 2.8e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM05860.1 - 5.7e-07 29.1 0.0 1.1e-06 28.2 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CCM05860.1 - 0.026 13.3 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CCM05860.1 - 0.029 14.3 0.1 0.05 13.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CCM05860.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WAPL PF07814.13 CCM05861.1 - 4e-17 62.1 2.8 2e-15 56.5 1.3 2.7 2 1 0 2 2 2 2 Wings apart-like protein regulation of heterochromatin BIR PF00653.21 CCM05862.1 - 4.1e-40 136.3 5.5 3.9e-20 72.3 1.7 2.4 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 CCM05862.1 - 4.5e-05 23.5 2.4 0.18 11.8 0.0 2.6 2 0 0 2 2 2 2 C3HC zinc finger-like zf-BED PF02892.15 CCM05862.1 - 0.0023 17.9 0.0 0.33 11.0 0.0 2.6 2 0 0 2 2 2 2 BED zinc finger Pkinase PF00069.25 CCM05863.1 - 1.4e-51 175.4 0.0 2e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05863.1 - 4.3e-28 98.3 0.0 5.4e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM05863.1 - 0.00018 20.9 0.0 0.00028 20.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CCM05863.1 - 0.0055 16.1 0.0 0.0092 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CCM05863.1 - 0.0069 16.0 0.0 0.21 11.2 0.0 2.1 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.11 CCM05863.1 - 0.059 12.3 0.1 0.059 12.3 0.1 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase zf-C3HC4_3 PF13920.6 CCM05864.1 - 0.00016 21.4 2.8 0.00024 20.9 2.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 CCM05864.1 - 0.00062 19.5 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4 PF00097.25 CCM05864.1 - 0.0013 18.6 4.0 0.0021 17.9 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCM05864.1 - 0.0014 18.5 4.7 0.0024 17.7 4.7 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCM05864.1 - 0.01 15.8 3.9 0.018 15.0 3.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CCM05864.1 - 0.3 11.5 3.7 0.52 10.7 3.7 1.4 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 CCM05864.1 - 1.2 9.0 4.9 3.1 7.7 5.0 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM05864.1 - 1.6 8.8 3.7 3.6 7.7 3.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger MRJP PF03022.16 CCM05865.1 - 1.3e-23 83.8 0.0 2.4e-23 82.9 0.0 1.4 1 1 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 CCM05865.1 - 7e-07 29.1 0.0 0.0001 22.0 0.0 2.8 3 0 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 CCM05865.1 - 9.8e-05 22.5 2.6 0.028 14.6 0.0 3.5 3 1 1 4 4 4 2 Arylesterase DUF3429 PF11911.8 CCM05866.1 - 7.5e-38 130.1 15.1 1.2e-37 129.4 15.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) DUF2378 PF09536.10 CCM05866.1 - 0.0022 17.9 0.1 0.005 16.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2378) zf-Di19 PF05605.12 CCM05866.1 - 0.017 15.4 1.6 0.017 15.4 1.6 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Transpos_assoc PF13963.6 CCM05866.1 - 0.21 11.9 1.8 7.7 6.9 0.1 2.9 2 1 1 3 3 3 0 Transposase-associated domain Zn-C2H2_12 PF18112.1 CCM05866.1 - 9.1 6.8 6.5 0.66 10.5 0.2 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FOXP-CC PF16159.5 CCM05867.1 - 0.03 14.9 8.9 1.5 9.5 1.9 2.9 3 1 0 3 3 3 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 CCM05867.1 - 0.083 13.4 0.2 0.083 13.4 0.2 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM05867.1 - 0.084 13.3 3.3 1.5 9.4 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCM05867.1 - 0.86 10.6 8.5 2.7 9.1 0.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger CRIM PF16978.5 CCM05868.1 - 5.8e-43 146.4 0.0 5.8e-43 146.4 0.0 2.4 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 CCM05868.1 - 9.5e-31 106.3 0.4 2.2e-30 105.2 0.4 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 CCM05868.1 - 6.2e-05 23.1 0.0 0.00028 21.0 0.0 2.1 2 0 0 2 2 2 1 TUG ubiquitin-like domain RBD PF02196.15 CCM05868.1 - 0.029 14.4 0.0 0.26 11.4 0.1 2.3 2 0 0 2 2 2 0 Raf-like Ras-binding domain TFIIA PF03153.13 CCM05868.1 - 0.052 13.5 4.7 0.12 12.4 4.7 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BLM_N PF16202.5 CCM05868.1 - 0.11 11.6 9.9 0.27 10.3 9.9 1.6 1 0 0 1 1 1 0 N-terminal region of Bloom syndrome protein Fe-S_biosyn PF01521.20 CCM05869.1 - 6.8e-13 48.8 0.0 8.9e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis bZIP_1 PF00170.21 CCM05871.1 - 6.5e-05 23.0 3.1 9.6e-05 22.4 3.1 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CCM05871.1 - 0.091 12.9 3.4 0.14 12.3 3.4 1.2 1 0 0 1 1 1 0 Basic region leucine zipper TolA_bind_tri PF16331.5 CCM05872.1 - 0.013 15.5 1.2 0.022 14.8 1.2 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation FlgD_ig PF13860.6 CCM05872.1 - 0.071 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 FlgD Ig-like domain SOGA PF11365.8 CCM05872.1 - 0.17 13.0 2.0 0.22 12.7 0.9 1.7 2 0 0 2 2 2 0 Protein SOGA Spc24 PF08286.11 CCM05872.1 - 0.26 11.5 0.4 0.42 10.9 0.4 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 End3 PF12761.7 CCM05872.1 - 0.46 10.6 2.4 0.7 10.0 2.4 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF3736 PF12540.8 CCM05872.1 - 1.4 9.1 7.6 0.37 10.9 1.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3736) TSC22 PF01166.18 CCM05872.1 - 2.3 8.6 3.8 4.5 7.7 1.5 2.1 2 0 0 2 2 2 0 TSC-22/dip/bun family YCII PF03795.14 CCM05874.1 - 0.00026 21.3 0.0 0.00032 21.0 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain CTP_transf_like PF01467.26 CCM05875.1 - 4.1e-25 88.7 0.0 5.5e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Amidohydro_1 PF01979.20 CCM05876.1 - 7.6e-23 81.4 0.0 2.6e-17 63.2 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 CCM05876.1 - 1.1e-12 48.2 0.0 1.9e-09 37.5 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family VSG_B PF13206.6 CCM05877.1 - 6.1 6.0 10.4 0.099 11.9 2.3 2.0 2 0 0 2 2 2 0 Trypanosomal VSG domain LMBR1 PF04791.16 CCM05878.1 - 0.013 14.4 0.2 0.014 14.3 0.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Pup PF05639.11 CCM05878.1 - 0.036 15.0 1.3 0.11 13.4 1.3 1.8 1 0 0 1 1 1 0 Pup-like protein Asp-B-Hydro_N PF05279.11 CCM05878.1 - 0.076 13.1 1.2 0.11 12.6 1.2 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region NYD-SP28 PF14772.6 CCM05878.1 - 0.13 12.3 5.9 5.4 7.1 2.6 2.7 2 1 1 3 3 3 0 Sperm tail Cdh1_DBD_1 PF18196.1 CCM05878.1 - 0.17 12.2 2.6 0.5 10.7 2.2 2.0 1 1 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 ABC_membrane PF00664.23 CCM05879.1 - 3.3e-51 174.5 5.2 4.6e-51 174.1 5.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CCM05879.1 - 2e-30 106.1 0.0 4.9e-30 104.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCM05879.1 - 2.3e-06 27.2 0.2 0.0017 17.8 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 CCM05879.1 - 0.012 15.7 0.0 0.031 14.4 0.0 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_16 PF13191.6 CCM05879.1 - 0.018 15.4 1.6 0.088 13.2 0.5 2.7 2 1 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 CCM05879.1 - 0.021 14.1 0.0 0.054 12.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.6 CCM05879.1 - 0.066 13.0 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 CCM05879.1 - 0.072 12.3 0.1 0.16 11.1 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain Proton_antipo_N PF00662.20 CCM05879.1 - 0.24 11.5 2.4 15 5.8 0.1 2.9 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus PGP_phosphatase PF09419.10 CCM05880.1 - 3.6e-43 147.1 0.0 4.8e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 CCM05880.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like DUF3719 PF12516.8 CCM05880.1 - 0.096 12.4 0.1 0.34 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) IML1 PF12257.8 CCM05881.1 - 5.8e-109 363.6 0.0 8.6e-109 363.1 0.0 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 CCM05881.1 - 4.4e-18 65.1 0.0 8.8e-18 64.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) BTB PF00651.31 CCM05882.1 - 1.8e-14 53.9 0.0 8.6e-09 35.6 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Pantoate_transf PF02548.15 CCM05883.1 - 2e-99 332.2 0.2 2.3e-99 332.0 0.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 CCM05883.1 - 7.7e-07 28.8 0.4 2.4e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Sun2_CC2 PF18580.1 CCM05883.1 - 0.34 11.2 1.0 1.4 9.2 0.0 2.4 3 0 0 3 3 3 0 SUN2 coiled coil domain 2 DUF5320 PF17253.2 CCM05884.1 - 0.072 14.2 15.2 3.5 8.7 5.7 3.4 2 1 1 3 3 3 0 Family of unknown function (DUF5320) Kri1_C PF12936.7 CCM05885.1 - 9.4e-27 93.0 0.1 9.4e-27 93.0 0.1 5.2 7 0 0 7 7 7 1 KRI1-like family C-terminal Kri1 PF05178.12 CCM05885.1 - 6.1e-25 87.8 8.3 6.1e-25 87.8 8.3 7.2 7 1 0 7 7 7 3 KRI1-like family SAP PF02037.27 CCM05885.1 - 2.6 7.9 12.0 0.3 10.9 0.4 3.3 3 0 0 3 3 3 0 SAP domain DUF4646 PF15496.6 CCM05886.1 - 2.6e-42 144.4 0.0 4.1e-42 143.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) PARP PF00644.20 CCM05888.1 - 2.7e-05 23.9 0.9 6.9e-05 22.5 0.6 1.8 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Cyclin_N PF00134.23 CCM05891.1 - 7.2e-06 25.8 0.0 1.2e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CCM05891.1 - 0.0014 19.0 0.3 0.0027 18.1 0.3 1.5 1 0 0 1 1 1 1 Cyclin Coilin_N PF15862.5 CCM05892.1 - 8.7e-06 25.6 1.6 2.4e-05 24.2 0.1 2.4 2 1 0 2 2 2 1 Coilin N-terminus Macoilin PF09726.9 CCM05892.1 - 0.39 9.2 14.1 0.55 8.7 14.1 1.1 1 0 0 1 1 1 0 Macoilin family TEX19 PF15553.6 CCM05892.1 - 1.3 9.0 4.5 2.5 8.0 0.1 2.4 2 0 0 2 2 2 0 Testis-expressed protein 19 PAP1 PF08601.10 CCM05892.1 - 5.3 6.7 22.9 9 5.9 22.9 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 SPX PF03105.19 CCM05892.1 - 5.4 6.8 19.7 1.5 8.7 16.7 1.5 2 0 0 2 2 2 0 SPX domain FXMRP1_C_core PF12235.8 CCM05892.1 - 7.2 7.3 10.2 20 5.9 10.2 1.7 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Sec63 PF02889.16 CCM05893.1 - 4.8e-17 62.0 0.0 3.3e-16 59.2 0.0 2.3 2 1 0 2 2 2 1 Sec63 Brl domain DnaJ PF00226.31 CCM05893.1 - 1.7e-13 50.5 0.1 4.2e-13 49.2 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Na_H_Exchanger PF00999.21 CCM05894.1 - 2.9e-20 72.4 26.5 1.6e-09 37.0 4.0 4.3 3 2 0 3 3 3 3 Sodium/hydrogen exchanger family p450 PF00067.22 CCM05895.1 - 1.6e-56 192.0 0.0 5.2e-56 190.3 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 CCM05897.1 - 3e-09 36.3 0.0 5e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM05897.1 - 7.8e-05 22.7 7.4 7.8e-05 22.7 7.4 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gp_dh_C PF02800.20 CCM05898.1 - 9.2e-68 226.8 0.0 1.5e-67 226.2 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CCM05898.1 - 1.5e-32 111.9 0.0 3.1e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain TUSC2 PF15000.6 CCM05899.1 - 0.055 13.7 3.8 0.46 10.8 3.8 2.7 1 0 0 1 1 1 0 Tumour suppressor candidate 2 Complex1_LYR PF05347.15 CCM05900.1 - 5.2e-10 39.2 0.8 7.5e-10 38.7 0.8 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CCM05900.1 - 0.00016 22.4 0.3 0.0002 22.0 0.3 1.2 1 0 0 1 1 1 1 Complex1_LYR-like PP28 PF10252.9 CCM05901.1 - 2.8e-25 88.6 16.0 2.8e-25 88.6 16.0 2.8 3 1 0 3 3 3 1 Casein kinase substrate phosphoprotein PP28 PPR_2 PF13041.6 CCM05902.1 - 0.00076 19.6 0.0 0.035 14.3 0.0 2.9 3 0 0 3 3 3 1 PPR repeat family RRM_1 PF00076.22 CCM05903.1 - 9.8e-15 54.1 0.0 1.3e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCM05903.1 - 0.00013 21.8 0.0 0.00019 21.3 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RINGv PF12906.7 CCM05904.1 - 2.3e-05 24.4 9.0 4.7e-05 23.4 9.0 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CCM05904.1 - 0.015 15.6 6.2 0.027 14.8 6.2 1.4 1 0 0 1 1 1 0 Ring finger domain PhnA_Zn_Ribbon PF08274.12 CCM05904.1 - 0.018 15.0 0.2 0.041 13.8 0.2 1.5 1 0 0 1 1 1 0 PhnA Zinc-Ribbon FANCL_C PF11793.8 CCM05904.1 - 0.092 12.9 4.3 0.16 12.1 4.3 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CCM05904.1 - 0.16 11.6 1.9 0.51 10.0 1.9 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type eIF2_C PF09173.11 CCM05905.1 - 5.3e-34 116.3 0.7 1.1e-33 115.3 0.7 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 CCM05905.1 - 1.1e-11 45.0 0.3 1.1e-11 45.0 0.3 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 CCM05905.1 - 1.4e-09 37.8 0.1 3.1e-09 36.7 0.2 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 CCM05905.1 - 0.0065 16.5 0.2 0.012 15.6 0.2 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Dak1_2 PF13684.6 CCM05905.1 - 0.085 11.9 0.3 0.13 11.3 0.3 1.3 1 0 0 1 1 1 0 Dihydroxyacetone kinase family RsgA_GTPase PF03193.16 CCM05905.1 - 0.099 12.5 0.2 0.099 12.5 0.2 1.6 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 CCM05906.1 - 0.00084 18.9 0.8 0.0015 18.1 0.8 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain dNK PF01712.19 CCM05906.1 - 0.18 11.6 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase RasGEF PF00617.19 CCM05908.1 - 4.5e-23 82.4 0.0 8.4e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CCM05908.1 - 7.9e-09 35.7 0.1 1.7e-08 34.6 0.1 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Ldh_1_N PF00056.23 CCM05909.1 - 1.2e-45 155.1 0.3 1.8e-45 154.5 0.3 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CCM05909.1 - 1.4e-42 145.4 0.0 2.1e-42 144.9 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 CCM05909.1 - 0.00018 20.6 0.0 0.00027 20.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 CCM05909.1 - 0.28 10.5 2.9 1.6 8.0 0.5 2.9 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GMC_oxred_N PF00732.19 CCM05910.1 - 3.5e-59 200.6 0.0 4.7e-59 200.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05910.1 - 2.7e-33 115.5 0.3 5.5e-33 114.5 0.3 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCM05910.1 - 0.0035 16.4 0.3 0.0056 15.8 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCM05910.1 - 0.017 14.2 0.3 0.23 10.5 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 CCM05910.1 - 0.032 13.8 0.9 0.13 11.8 0.9 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase GMC_oxred_N PF00732.19 CCM05911.1 - 6.1e-57 193.2 0.0 9.1e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05911.1 - 8.9e-34 117.1 0.1 1.6e-33 116.3 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCM05911.1 - 0.00014 21.0 0.4 0.00024 20.3 0.4 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CCM05911.1 - 0.0025 17.0 0.7 0.092 11.8 0.2 2.2 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 CCM05911.1 - 0.0065 16.1 2.1 0.11 12.0 1.3 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CCM05911.1 - 0.012 14.9 0.8 0.03 13.6 0.2 2.0 2 0 0 2 2 2 0 Thi4 family Trp_halogenase PF04820.14 CCM05911.1 - 0.22 10.3 0.1 0.31 9.8 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase GMC_oxred_N PF00732.19 CCM05912.1 - 7.7e-54 183.1 0.0 1e-53 182.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05912.1 - 1.5e-33 116.3 0.0 2.7e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCM05912.1 - 0.0023 17.1 0.3 0.0037 16.4 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CCM05912.1 - 0.017 14.7 0.6 0.29 10.7 0.3 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 CCM05912.1 - 0.02 14.1 0.6 0.041 13.1 0.2 1.7 2 0 0 2 2 2 0 Thi4 family GMC_oxred_N PF00732.19 CCM05913.1 - 2.4e-65 220.8 0.0 3.2e-65 220.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM05913.1 - 2e-32 112.7 0.1 3.5e-32 111.9 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CCM05913.1 - 1.7e-05 24.0 0.9 4e-05 22.8 0.9 1.6 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CCM05913.1 - 0.00085 19.0 2.2 0.012 15.2 0.3 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM05913.1 - 0.0017 17.5 1.5 0.13 11.4 0.5 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CCM05913.1 - 0.0026 18.0 0.3 0.0088 16.3 0.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCM05913.1 - 0.0027 17.0 0.8 0.0053 16.0 0.3 1.8 2 0 0 2 2 2 1 Thi4 family RNA_pol_I_A49 PF06870.12 CCM05914.1 - 1.6e-116 389.4 0.6 1.8e-116 389.2 0.6 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor SRI PF08236.11 CCM05915.1 - 4.3e-19 68.5 11.3 9.9e-19 67.3 11.3 1.6 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain AWS PF17907.1 CCM05915.1 - 3.6e-14 52.5 9.1 3.6e-14 52.5 9.1 2.4 2 0 0 2 2 2 1 AWS domain SET PF00856.28 CCM05915.1 - 1.1e-13 52.0 0.0 1.1e-13 52.0 0.0 3.2 2 2 1 3 3 3 1 SET domain Ish1 PF10281.9 CCM05916.1 - 1.7e-54 181.8 26.5 5.8e-11 42.5 1.7 7.4 7 0 0 7 7 7 7 Putative stress-responsive nuclear envelope protein HeH PF12949.7 CCM05916.1 - 0.0011 18.7 0.0 33 4.3 0.0 5.1 5 0 0 5 5 5 1 HeH/LEM domain NHase_alpha PF02979.16 CCM05916.1 - 0.094 12.0 8.6 2 7.7 0.1 3.6 2 2 1 3 3 3 0 Nitrile hydratase, alpha chain Apolipoprotein PF01442.18 CCM05916.1 - 0.55 10.1 4.8 0.9 9.4 0.4 3.0 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 CCM05916.1 - 3.9 8.1 8.2 16 6.1 0.3 3.9 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF883) MFS_1 PF07690.16 CCM05917.1 - 1.2e-18 67.2 41.0 1.3e-13 50.6 16.8 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily UPF0239 PF06783.11 CCM05917.1 - 0.11 12.7 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF1365 PF07103.11 CCM05918.1 - 2.9e-66 223.6 0.0 4.8e-66 222.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) Lipase_GDSL PF00657.22 CCM05919.1 - 4.6e-14 52.9 0.0 2.9e-10 40.5 0.0 2.9 2 1 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 CCM05919.1 - 6.3e-09 36.5 1.6 0.00027 21.4 0.2 2.6 3 0 0 3 3 3 2 GDSL-like Lipase/Acylhydrolase family DUF1989 PF09347.10 CCM05919.1 - 0.026 14.2 0.2 0.24 11.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1989) Pkinase_Tyr PF07714.17 CCM05920.1 - 1.1e-40 139.6 0.0 1.6e-40 139.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CCM05920.1 - 1.1e-34 120.0 0.0 2.9e-34 118.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.6 CCM05920.1 - 2e-07 30.6 0.0 3.4e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCM05920.1 - 0.014 15.3 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CCM05920.1 - 0.058 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Baculo_LEF5 PF04838.12 CCM05920.1 - 0.25 11.4 0.2 0.49 10.4 0.2 1.4 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 ASF1_hist_chap PF04729.13 CCM05921.1 - 6.5e-63 211.3 0.0 7.6e-63 211.1 0.0 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone F-box PF00646.33 CCM05922.1 - 0.00012 21.9 0.2 0.00035 20.4 0.2 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCM05922.1 - 0.00037 20.3 0.7 0.0015 18.4 0.7 2.1 1 0 0 1 1 1 1 F-box-like DUF86 PF01934.17 CCM05922.1 - 0.16 11.9 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF86 HMMR_C PF15908.5 CCM05923.1 - 0.031 14.5 0.4 0.031 14.5 0.4 2.5 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal DUF4691 PF15762.5 CCM05923.1 - 0.038 14.2 0.5 0.08 13.1 0.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4691) FapA PF03961.13 CCM05923.1 - 0.11 11.1 5.2 0.038 12.6 1.8 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A Macoilin PF09726.9 CCM05923.1 - 0.11 11.0 8.2 0.15 10.6 8.2 1.2 1 0 0 1 1 1 0 Macoilin family FlaC_arch PF05377.11 CCM05923.1 - 0.14 12.6 4.4 14 6.1 0.0 3.6 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DUF1515 PF07439.11 CCM05923.1 - 0.18 11.8 1.6 0.31 11.1 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Exonuc_VII_L PF02601.15 CCM05923.1 - 0.19 11.3 2.4 0.17 11.4 1.5 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF812 PF05667.11 CCM05923.1 - 0.23 10.3 7.5 0.33 9.8 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Tropomyosin_1 PF12718.7 CCM05923.1 - 0.57 10.3 17.6 0.25 11.5 9.5 2.7 1 1 1 2 2 2 0 Tropomyosin like TPR_MLP1_2 PF07926.12 CCM05923.1 - 0.68 10.0 11.6 3.7 7.6 1.2 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 CCM05923.1 - 0.87 10.1 16.2 66 4.0 16.2 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region ADIP PF11559.8 CCM05923.1 - 1.3 9.1 12.2 0.52 10.4 1.9 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 CCM05923.1 - 1.6 8.8 4.2 7.2 6.7 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 CCM05923.1 - 2.5 8.3 17.1 1.6 9.0 6.3 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DivIC PF04977.15 CCM05923.1 - 6.7 6.6 18.6 3.4 7.5 1.9 3.8 2 2 2 4 4 4 0 Septum formation initiator UCH PF00443.29 CCM05924.1 - 2.2e-36 125.7 0.0 5.4e-36 124.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCM05924.1 - 6.4e-13 49.0 1.4 5.5e-12 45.9 1.4 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CCM05924.1 - 3.6e-05 23.4 0.0 9.2e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Bap31 PF05529.12 CCM05925.1 - 7.8e-44 148.8 3.5 1.3e-43 148.1 3.5 1.4 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 CCM05925.1 - 5.3e-11 42.3 9.9 5.3e-11 42.3 9.9 2.1 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain Dynamitin PF04912.14 CCM05925.1 - 0.067 12.5 7.9 0.084 12.2 7.9 1.1 1 0 0 1 1 1 0 Dynamitin Cortexin PF11057.8 CCM05925.1 - 0.089 12.7 1.8 2 8.3 0.1 2.4 2 0 0 2 2 2 0 Cortexin of kidney DUF724 PF05266.14 CCM05925.1 - 0.48 10.2 7.1 0.66 9.8 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CLN3 PF02487.17 CCM05925.1 - 0.6 9.1 3.6 0.12 11.4 0.2 1.5 2 0 0 2 2 2 0 CLN3 protein DUF4337 PF14235.6 CCM05925.1 - 9.5 6.3 10.4 20 5.3 10.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) BAG PF02179.16 CCM05926.1 - 2.1e-07 31.3 1.3 7.1e-07 29.6 1.0 2.1 1 1 0 1 1 1 1 BAG domain MCM_lid PF17855.1 CCM05926.1 - 0.0085 16.5 0.2 0.14 12.6 0.0 2.4 2 0 0 2 2 2 1 MCM AAA-lid domain dCMP_cyt_deam_1 PF00383.23 CCM05927.1 - 2.4e-08 33.8 0.1 3.5e-08 33.3 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CCM05927.1 - 0.001 18.8 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase PEMT PF04191.13 CCM05928.1 - 2.9e-50 169.1 18.0 4e-29 101.1 2.2 3.5 4 0 0 4 4 4 2 Phospholipid methyltransferase ApoLp-III PF07464.11 CCM05928.1 - 0.0099 16.0 0.1 0.017 15.2 0.1 1.3 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) PP-binding PF00550.25 CCM05928.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 Phosphopantetheine attachment site SKICH PF17751.1 CCM05928.1 - 0.015 15.8 0.0 0.05 14.2 0.0 1.9 1 1 0 1 1 1 0 SKICH domain Sas10 PF09368.10 CCM05929.1 - 9.2e-27 93.3 6.0 9.2e-27 93.3 6.0 2.7 3 1 1 4 4 4 1 Sas10 C-terminal domain Fungal_trans PF04082.18 CCM05930.1 - 1.7e-07 30.6 0.2 2.6e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM05930.1 - 7.2e-05 22.8 4.0 7.2e-05 22.8 4.0 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tom22 PF04281.13 CCM05931.1 - 4.2e-40 136.7 1.1 5e-40 136.5 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 SR-25 PF10500.9 CCM05931.1 - 2.7 7.6 6.9 4.9 6.7 6.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NAD_binding_10 PF13460.6 CCM05932.1 - 9.7e-14 51.7 0.0 1.6e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CCM05932.1 - 4.4e-11 42.8 0.0 6.1e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CCM05932.1 - 1.4e-10 41.0 0.3 8.1e-10 38.6 0.3 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CCM05932.1 - 5.9e-09 35.4 0.0 1.5e-07 30.8 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CCM05932.1 - 6.5e-09 35.2 0.1 2.4e-08 33.3 0.0 1.8 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CCM05932.1 - 3.4e-06 26.4 0.3 0.011 14.9 0.0 3.2 1 1 1 3 3 3 2 Male sterility protein GDP_Man_Dehyd PF16363.5 CCM05932.1 - 7.4e-05 22.3 0.2 0.00021 20.8 0.2 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CCM05932.1 - 0.0061 16.0 0.0 0.012 15.1 0.0 1.5 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05932.1 - 0.0097 15.5 0.1 0.018 14.6 0.1 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CCM05932.1 - 0.087 11.9 0.0 0.22 10.6 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DUF2462 PF09495.10 CCM05933.1 - 1.6e-21 76.8 12.4 2.6e-21 76.1 12.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) HTH_Tnp_Tc5 PF03221.16 CCM05934.1 - 3.9e-14 52.4 0.1 9e-14 51.3 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_Crp_2 PF13545.6 CCM05934.1 - 0.00037 20.4 0.0 0.001 19.0 0.0 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_23 PF13384.6 CCM05934.1 - 0.00051 19.7 0.1 0.013 15.3 0.0 2.8 3 0 0 3 3 3 1 Homeodomain-like domain HTH_31 PF13560.6 CCM05934.1 - 0.0016 18.7 0.0 2.6 8.4 0.0 3.1 2 1 0 2 2 2 2 Helix-turn-helix domain MarR PF01047.22 CCM05934.1 - 0.0034 17.3 0.0 0.0074 16.2 0.0 1.5 1 0 0 1 1 1 1 MarR family CENP-B_N PF04218.13 CCM05934.1 - 0.0042 16.7 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DUF1633 PF07794.11 CCM05934.1 - 0.034 12.3 2.9 0.051 11.8 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Sigma70_r4 PF04545.16 CCM05934.1 - 0.038 13.5 0.0 0.13 11.8 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 TnsD PF15978.5 CCM05934.1 - 0.055 12.5 1.1 0.081 11.9 1.1 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D HTH_38 PF13936.6 CCM05934.1 - 0.059 13.2 0.8 0.13 12.0 0.1 2.0 2 0 0 2 2 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CCM05934.1 - 0.067 13.1 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_37 PF13744.6 CCM05934.1 - 0.075 13.0 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain TrmB PF01978.19 CCM05934.1 - 0.075 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB PepSY_2 PF13670.6 CCM05934.1 - 0.086 12.9 0.2 0.23 11.5 0.2 1.7 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain HTH_28 PF13518.6 CCM05934.1 - 0.088 13.0 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_36 PF13730.6 CCM05934.1 - 0.1 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_4 PF13613.6 CCM05934.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease CAF1 PF04857.20 CCM05935.1 - 8e-22 77.8 0.1 2.2e-11 43.5 0.0 2.7 1 1 1 2 2 2 2 CAF1 family ribonuclease SH3_9 PF14604.6 CCM05936.1 - 2.7e-16 59.1 0.9 5.8e-10 38.9 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 CCM05936.1 - 4.1e-16 59.0 0.5 1.7e-15 57.1 0.5 2.1 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain C1_1 PF00130.22 CCM05936.1 - 1.2e-12 47.5 1.9 2.3e-12 46.6 1.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.17 CCM05936.1 - 1.7e-11 43.6 1.4 3.5e-07 29.8 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CCM05936.1 - 2.8e-10 39.6 3.1 2.8e-05 23.6 0.5 2.7 2 1 0 2 2 2 2 SH3 domain SH3_3 PF08239.11 CCM05936.1 - 0.00014 22.0 0.2 0.00033 20.9 0.2 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain DPBB_1 PF03330.18 CCM05937.1 - 0.088 13.1 0.1 0.25 11.6 0.1 1.9 1 1 0 1 1 1 0 Lytic transglycolase GPI-anchored PF10342.9 CCM05938.1 - 6.8e-05 23.6 1.2 6.8e-05 23.6 1.2 3.1 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family zf-C3H1 PF10650.9 CCM05939.1 - 0.038 13.7 1.7 0.072 12.8 1.7 1.5 1 0 0 1 1 1 0 Putative zinc-finger domain GxGYxYP_N PF16216.5 CCM05939.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 GxGYxY sequence motif in domain of unknown function N-terminal Bac_rhamnosid6H PF17389.2 CCM05941.1 - 6.3e-17 61.8 0.2 9.6e-17 61.2 0.2 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 CCM05941.1 - 1.9e-06 27.5 0.1 3.8e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Trehalase PF01204.18 CCM05941.1 - 0.03 13.2 0.3 0.044 12.6 0.3 1.1 1 0 0 1 1 1 0 Trehalase Bac_rhamnosid6H PF17389.2 CCM05942.1 - 1.4e-20 73.9 0.6 2.1e-20 73.3 0.6 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 CCM05942.1 - 2.2e-05 24.1 0.0 4.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Trehalase PF01204.18 CCM05942.1 - 0.00036 19.5 0.4 0.00055 18.9 0.4 1.1 1 0 0 1 1 1 1 Trehalase STE PF02200.16 CCM05944.1 - 5.9e-44 149.0 0.1 1.6e-43 147.6 0.0 1.7 2 0 0 2 2 2 1 STE like transcription factor zf-C2H2 PF00096.26 CCM05944.1 - 8e-11 41.8 13.4 4.6e-05 23.7 2.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM05944.1 - 2.8e-07 30.8 10.9 0.0023 18.6 1.4 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCM05944.1 - 1.6e-05 25.1 3.4 1.6e-05 25.1 3.4 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CCM05944.1 - 0.01 16.1 5.1 0.22 11.9 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 CCM05944.1 - 0.03 14.6 0.6 0.077 13.3 0.6 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2HE PF16278.5 CCM05944.1 - 1.3 9.6 5.7 87 3.7 5.7 2.5 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 CCM05944.1 - 6 7.0 9.7 0.12 12.4 1.6 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger OTU PF02338.19 CCM05945.1 - 1.2e-12 48.4 0.0 2.1e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CCM05945.1 - 0.0014 18.1 0.0 1.1 8.6 0.0 2.2 2 0 0 2 2 2 2 Peptidase C65 Otubain EAP30 PF04157.16 CCM05946.1 - 8.2e-34 116.9 0.0 1.3e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 CCM05946.1 - 5e-19 68.3 0.0 8.8e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-RanBP PF00641.18 CCM05946.1 - 1.7e-06 27.2 4.4 0.0086 15.4 0.9 2.5 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 CCM05946.1 - 0.0039 17.2 2.6 1.2 9.2 0.0 2.9 3 0 0 3 3 3 2 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 CCM05946.1 - 0.0076 15.6 0.9 0.0076 15.6 0.9 2.9 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF742 PF05331.11 CCM05946.1 - 0.048 13.5 0.1 0.96 9.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF742) DZR PF12773.7 CCM05946.1 - 0.092 12.8 6.3 0.11 12.5 0.6 2.4 2 1 1 3 3 3 0 Double zinc ribbon CTU2 PF10288.9 CCM05946.1 - 0.67 10.2 2.4 20 5.5 0.2 2.6 1 1 1 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 PigN PF04987.14 CCM05948.1 - 8.9e-125 417.1 37.6 6.1e-109 364.9 27.3 2.1 2 0 0 2 2 2 2 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 CCM05948.1 - 1.5e-11 44.5 1.9 5.8e-09 36.0 1.3 2.3 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CCM05948.1 - 0.00017 21.1 0.1 0.00028 20.4 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 CCM05948.1 - 0.00038 19.9 0.0 0.00067 19.1 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF4231 PF14015.6 CCM05948.1 - 7.1 7.2 8.3 3.7 8.1 1.4 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) PEMT PF04191.13 CCM05950.1 - 5.2e-30 104.0 5.0 1e-29 103.1 4.1 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase ABC1 PF03109.16 CCM05951.1 - 2.5e-25 89.0 0.0 4.5e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 CCM05951.1 - 0.026 13.9 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Remorin_N PF03766.13 CCM05952.1 - 0.074 13.1 2.4 0.2 11.7 2.4 1.7 1 0 0 1 1 1 0 Remorin, N-terminal region adh_short_C2 PF13561.6 CCM05953.1 - 9.1e-36 123.6 0.2 1.1e-35 123.3 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM05953.1 - 4.3e-27 94.9 0.5 6.3e-27 94.3 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CCM05953.1 - 1.8e-05 24.7 0.1 3.5e-05 23.8 0.0 1.5 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 CCM05953.1 - 0.0012 18.3 0.0 0.0016 17.9 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Aldo_ket_red PF00248.21 CCM05954.1 - 1.3e-64 218.2 0.2 1.5e-64 218.0 0.2 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NAPRTase_N PF17767.1 CCM05954.1 - 0.027 14.9 0.1 8.9 6.7 0.0 2.4 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Aldo_ket_red PF00248.21 CCM05958.1 - 3e-57 194.1 0.1 5e-55 186.8 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family TPR_10 PF13374.6 CCM05959.1 - 9.3e-12 44.4 0.8 0.88 9.5 0.0 10.8 12 1 1 13 13 13 1 Tetratricopeptide repeat TPR_12 PF13424.6 CCM05959.1 - 2.2e-09 37.5 0.3 0.51 10.7 0.0 8.0 5 2 3 8 8 8 1 Tetratricopeptide repeat Lipoprotein_20 PF13942.6 CCM05959.1 - 7.5e-05 22.7 4.9 35 4.3 0.0 8.3 10 0 0 10 10 10 0 YfhG lipoprotein bZIP_Maf PF03131.17 CCM05959.1 - 0.00011 22.7 0.0 2.1 8.9 0.0 4.6 5 0 0 5 5 5 2 bZIP Maf transcription factor Flp_Fap PF04964.14 CCM05959.1 - 0.0016 18.2 0.1 61 3.6 0.0 6.1 8 0 0 8 8 8 0 Flp/Fap pilin component DUF2063 PF09836.9 CCM05959.1 - 0.034 14.4 0.3 36 4.7 0.0 4.4 6 0 0 6 6 5 0 Putative DNA-binding domain HTH_ABP1_N PF18107.1 CCM05959.1 - 0.037 13.7 6.0 12 5.7 0.1 4.9 5 0 0 5 5 5 0 Fission yeast centromere protein N-terminal domain DUF5486 PF17588.2 CCM05959.1 - 0.24 11.3 10.9 1.2e+02 2.7 0.0 6.9 8 0 0 8 8 8 0 Family of unknown function (DUF5486) BLOC1_2 PF10046.9 CCM05959.1 - 0.27 11.6 7.0 44 4.5 0.0 6.0 7 1 0 7 7 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_assoc_2 PF16193.5 CCM05959.1 - 1.4 9.3 7.9 93 3.5 0.1 5.5 5 2 0 5 5 5 0 AAA C-terminal domain G2BR PF18442.1 CCM05959.1 - 1.7 8.3 4.2 1.3e+02 2.3 0.0 4.3 5 0 0 5 5 5 0 E3 gp78 Ube2g2-binding region (G2BR) TPR_14 PF13428.6 CCM05960.1 - 2.4e-06 27.9 1.1 18 6.5 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCM05960.1 - 4.2e-06 26.4 0.0 25 4.9 0.1 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 CCM05960.1 - 0.0042 17.2 0.0 1.3e+02 3.2 0.0 5.9 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCM05960.1 - 0.09 12.9 0.0 61 4.1 0.0 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 CCM05961.1 - 9.9e-22 78.1 0.0 1.8e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Caspase domain DUF3632 PF12311.8 CCM05962.1 - 3.8e-41 141.4 0.0 6.3e-41 140.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) CHAT PF12770.7 CCM05963.1 - 1.6e-33 116.3 0.0 2.5e-33 115.7 0.0 1.3 1 0 0 1 1 1 1 CHAT domain TPR_10 PF13374.6 CCM05963.1 - 2.7e-20 71.6 0.1 0.5 10.3 0.0 13.3 15 0 0 15 15 15 5 Tetratricopeptide repeat TPR_8 PF13181.6 CCM05963.1 - 4e-17 60.9 0.0 6.7 7.2 0.0 14.9 16 0 0 16 16 16 1 Tetratricopeptide repeat TPR_2 PF07719.17 CCM05963.1 - 0.00012 21.9 0.0 47 4.5 0.0 8.1 9 0 0 9 9 9 0 Tetratricopeptide repeat ATP-synt_ab PF00006.25 CCM05963.1 - 0.04 13.6 0.0 22 4.6 0.0 4.0 5 0 0 5 5 5 0 ATP synthase alpha/beta family, nucleotide-binding domain TSGP1 PF07771.11 CCM05963.1 - 1 9.5 2.7 1.9 8.7 2.7 1.4 1 0 0 1 1 1 0 Tick salivary peptide group 1 Pea-VEAacid PF08111.11 CCM05963.1 - 3.1 8.3 6.5 0.85 10.1 0.1 3.5 3 0 0 3 3 3 0 Pea-VEAacid family Dus PF01207.17 CCM05964.1 - 5.8e-72 242.4 0.0 7.8e-72 242.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) SOR_SNZ PF01680.17 CCM05964.1 - 0.0014 18.5 0.0 0.02 14.7 0.0 2.1 1 1 1 2 2 2 1 SOR/SNZ family NMO PF03060.15 CCM05964.1 - 0.0019 17.7 0.0 0.0035 16.8 0.0 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 CCM05964.1 - 0.0049 16.2 0.0 0.0081 15.5 0.0 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 CCM05964.1 - 0.17 11.3 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator TFIIA_gamma_C PF02751.14 CCM05966.1 - 1.4e-23 82.8 0.1 2.3e-23 82.1 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 CCM05966.1 - 4.5e-16 58.6 0.9 7.4e-16 57.9 0.7 1.5 2 0 0 2 2 2 1 Transcription initiation factor IIA, gamma subunit, helical domain Phage-tail_1 PF09097.10 CCM05966.1 - 0.033 14.0 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 Scytalone_dh PF02982.14 CCM05966.1 - 0.088 12.6 0.0 0.097 12.5 0.0 1.1 1 0 0 1 1 1 0 Scytalone dehydratase zf-C2H2_4 PF13894.6 CCM05970.1 - 0.21 12.5 9.8 0.92 10.5 2.5 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 CCM05970.1 - 0.44 10.9 4.7 0.81 10.0 4.1 1.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 CCM05970.1 - 9.3 6.9 10.7 47 4.7 6.4 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type ADH_zinc_N PF00107.26 CCM05971.1 - 5.7e-27 94.3 0.0 1.1e-26 93.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM05971.1 - 3.8e-19 70.1 0.0 9.2e-19 68.8 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CCM05971.1 - 8.3e-06 25.6 0.0 3.6e-05 23.6 0.0 2.1 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain PA PF02225.22 CCM05971.1 - 0.016 15.2 0.1 0.043 13.8 0.1 1.7 1 0 0 1 1 1 0 PA domain R3H PF01424.22 CCM05973.1 - 1.8e-15 56.7 0.4 3.5e-15 55.7 0.4 1.5 1 0 0 1 1 1 1 R3H domain zf-Di19 PF05605.12 CCM05974.1 - 0.00025 21.2 0.2 0.00085 19.6 0.2 1.9 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 CCM05974.1 - 0.002 18.5 0.2 0.0077 16.6 0.2 2.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM05974.1 - 0.0073 17.1 3.8 0.026 15.4 0.2 3.3 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_12 PF18658.1 CCM05974.1 - 0.62 9.7 2.1 2.3 7.8 0.0 2.5 2 1 1 3 3 3 0 Zinc-finger C2H2-type zf-H2C2_2 PF13465.6 CCM05975.1 - 0.045 14.2 0.3 0.045 14.2 0.3 3.1 5 0 0 5 5 5 0 Zinc-finger double domain zf-C2H2 PF00096.26 CCM05975.1 - 0.58 10.7 11.5 0.14 12.6 3.8 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM05976.1 - 0.0041 17.8 4.8 0.072 14.0 0.3 3.4 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CCM05976.1 - 0.045 14.2 0.2 0.045 14.2 0.2 2.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 CCM05976.1 - 2.6 8.7 5.0 5.9 7.6 0.1 2.9 2 1 1 3 3 3 0 FOXP coiled-coil domain Phage_integrase PF00589.22 CCM05978.1 - 0.079 12.8 0.0 0.2 11.5 0.0 1.6 2 0 0 2 2 2 0 Phage integrase family Oxidored_FMN PF00724.20 CCM05979.1 - 6.6e-69 232.8 0.0 8.1e-69 232.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family FMN_dh PF01070.18 CCM05979.1 - 0.0075 15.3 1.7 0.019 14.0 0.7 1.8 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Dus PF01207.17 CCM05979.1 - 0.027 13.6 0.1 0.097 11.7 0.0 1.9 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) KR PF08659.10 CCM05979.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 KR domain Oxidored_FMN PF00724.20 CCM05980.1 - 2.3e-68 231.0 0.0 2.8e-68 230.7 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family FMN_dh PF01070.18 CCM05980.1 - 0.017 14.2 0.1 0.028 13.5 0.1 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Dus PF01207.17 CCM05980.1 - 0.018 14.2 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Pkinase PF00069.25 CCM05981.1 - 2.1e-74 250.2 0.0 3.3e-74 249.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM05981.1 - 2.6e-45 154.7 0.0 4.5e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 CCM05981.1 - 1.7e-36 124.2 3.1 1.9e-18 66.4 0.2 2.6 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 CCM05981.1 - 2.8e-09 36.7 0.0 8e-08 31.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CCM05981.1 - 0.00024 20.2 0.1 0.00055 19.0 0.0 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 CCM05981.1 - 0.0085 15.5 0.0 0.054 12.8 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4520 PF15016.6 CCM05981.1 - 0.029 14.4 0.1 0.084 13.0 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) APH PF01636.23 CCM05981.1 - 0.089 12.7 0.1 0.55 10.1 0.1 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family TFIIA PF03153.13 CCM05983.1 - 1.1e-05 25.7 5.7 1.1e-05 25.7 5.7 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 CCM05983.1 - 0.73 8.0 10.0 1.2 7.2 10.0 1.3 1 0 0 1 1 1 0 Nop14-like family Aldedh PF00171.22 CCM05988.1 - 1.9e-169 564.1 0.3 2.2e-169 563.9 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCM05988.1 - 0.068 12.6 0.0 2.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) TraF PF13728.6 CCM05991.1 - 0.061 13.1 0.5 0.16 11.8 0.5 1.7 1 0 0 1 1 1 0 F plasmid transfer operon protein Cupin_1 PF00190.22 CCM05994.1 - 8.3e-07 28.7 0.1 9e-07 28.6 0.1 1.1 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 CCM05994.1 - 9.7e-07 28.4 0.0 6e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 Cupin domain Oxidored_FMN PF00724.20 CCM05995.1 - 1.1e-05 24.9 0.0 1.3e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CCM05995.1 - 0.067 12.3 0.0 0.077 12.1 0.0 1.1 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) TaqI_C PF12950.7 CCM05997.1 - 0.16 12.1 0.2 0.23 11.5 0.2 1.2 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain adh_short_C2 PF13561.6 CCM05998.1 - 1.1e-57 195.2 4.0 4.7e-56 190.0 4.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM05998.1 - 1.2e-43 148.8 3.7 1.3e-42 145.5 3.7 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM05998.1 - 2.3e-10 40.7 1.5 3.5e-10 40.1 1.0 1.5 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 CCM05998.1 - 0.00012 21.6 0.0 0.00017 21.1 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CCM05998.1 - 0.00031 20.3 0.1 0.0024 17.4 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DFP PF04127.15 CCM05998.1 - 0.008 16.0 3.8 0.043 13.6 3.6 2.2 2 1 0 2 2 2 1 DNA / pantothenate metabolism flavoprotein THF_DHG_CYH_C PF02882.19 CCM05998.1 - 0.011 15.0 0.4 0.024 14.0 0.4 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain adh_short PF00106.25 CCM05999.1 - 2.8e-28 98.7 0.0 3.7e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM05999.1 - 2.8e-20 72.9 0.1 3.3e-20 72.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM05999.1 - 7e-09 35.8 0.1 9.8e-09 35.4 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM05999.1 - 0.0053 16.7 0.1 0.011 15.6 0.1 1.4 1 1 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 CCM05999.1 - 0.14 12.8 0.0 4.6 7.9 0.0 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 CCM06000.1 - 1.9e-29 102.5 0.0 2.5e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06000.1 - 8.9e-18 64.7 0.0 1.1e-17 64.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06000.1 - 1.3e-09 38.2 0.0 1.9e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM06000.1 - 0.00025 21.0 0.0 0.00038 20.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CCM06001.1 - 2.3e-23 82.7 0.0 3.1e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06001.1 - 5.6e-19 68.6 0.0 7.8e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCM06001.1 - 0.016 15.1 0.2 0.024 14.5 0.2 1.6 1 1 0 1 1 1 0 NAD(P)H-binding KR PF08659.10 CCM06001.1 - 0.017 15.1 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 KR domain E1-E2_ATPase PF00122.20 CCM06003.1 - 4.3 6.8 8.4 7.8 6.0 0.0 2.8 2 1 0 2 2 2 0 E1-E2 ATPase Peptidase_S10 PF00450.22 CCM06004.1 - 1.7e-110 370.4 0.0 2.1e-110 370.0 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase FA_desaturase PF00487.24 CCM06005.1 - 0.11 12.3 2.2 0.25 11.1 2.2 1.5 1 0 0 1 1 1 0 Fatty acid desaturase FixS PF03597.15 CCM06006.1 - 0.35 10.6 2.0 1.1 9.1 2.0 1.8 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type adh_short PF00106.25 CCM06007.1 - 5.1e-25 88.1 0.0 7e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06007.1 - 3.3e-20 72.7 0.1 3.9e-20 72.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06007.1 - 1.6e-06 28.1 0.0 2.3e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CCM06007.1 - 0.0055 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CCM06007.1 - 0.0059 16.1 0.2 0.011 15.2 0.2 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family BRI3BP PF14965.6 CCM06008.1 - 0.0035 16.9 1.5 0.0035 16.9 1.5 3.1 2 1 0 3 3 3 2 Negative regulator of p53/TP53 TipE PF16972.5 CCM06008.1 - 0.027 13.7 0.2 0.038 13.2 0.2 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE WD40 PF00400.32 CCM06010.1 - 1.4e-22 79.5 12.6 8.7e-08 32.7 0.1 4.8 5 1 0 5 5 5 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CCM06010.1 - 3.6e-07 29.5 0.0 0.0047 15.9 0.0 3.1 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 CCM06010.1 - 3.9e-07 30.3 0.2 0.2 12.0 0.1 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 CCM06010.1 - 1.2e-05 24.3 3.1 0.0038 16.0 0.1 2.8 1 1 2 3 3 3 2 Nup133 N terminal like PD40 PF07676.12 CCM06010.1 - 0.00022 21.1 0.1 8.5 6.5 0.0 3.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCM06010.1 - 0.0012 17.4 4.2 0.0087 14.6 0.6 2.0 1 1 1 2 2 2 2 Cytochrome D1 heme domain Gmad1 PF10647.9 CCM06010.1 - 0.0015 18.4 1.9 1.2 8.8 0.1 3.4 1 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain WD40_like PF17005.5 CCM06010.1 - 0.0052 16.1 0.0 0.053 12.8 0.0 2.0 1 1 1 2 2 2 1 WD40-like domain Nup160 PF11715.8 CCM06010.1 - 0.057 12.1 1.4 2.4 6.7 0.1 2.8 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DUF4448 PF14610.6 CCM06011.1 - 0.028 14.2 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) RabGAP-TBC PF00566.18 CCM06012.1 - 5.4e-08 32.8 0.4 0.00011 21.9 0.1 2.2 1 1 1 2 2 2 2 Rab-GTPase-TBC domain Pro-kuma_activ PF09286.11 CCM06013.1 - 2.2e-45 154.4 0.0 4.4e-45 153.5 0.0 1.5 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CCM06013.1 - 2.3e-05 23.8 1.2 4e-05 23.0 1.2 1.3 1 0 0 1 1 1 1 Subtilase family ASH PF15780.5 CCM06013.1 - 0.01 16.0 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Vps39_1 PF10366.9 CCM06014.1 - 1.5e-07 31.6 0.9 2.5e-05 24.5 0.0 3.1 2 1 1 3 3 3 2 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 CCM06014.1 - 3.5e-06 27.4 0.0 9.7e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 CCM06014.1 - 4.7e-05 23.3 0.0 0.0014 18.5 0.0 2.6 2 0 0 2 2 2 1 Region in Clathrin and VPS CNH PF00780.22 CCM06015.1 - 0.00027 20.6 0.0 0.0034 17.0 0.0 2.5 1 1 0 1 1 1 1 CNH domain CBS PF00571.28 CCM06016.1 - 8.3e-14 51.8 0.6 0.0041 17.5 0.0 4.7 4 1 0 4 4 4 4 CBS domain Perilipin PF03036.16 CCM06017.1 - 2e-12 46.9 8.6 2.4e-07 30.2 0.0 2.4 2 1 0 2 2 2 2 Perilipin family Apolipoprotein PF01442.18 CCM06017.1 - 2e-05 24.6 5.2 0.00092 19.1 5.3 2.8 2 2 0 2 2 2 1 Apolipoprotein A1/A4/E domain Hormone_1 PF00103.20 CCM06017.1 - 0.028 14.1 1.5 0.06 13.1 1.5 1.5 1 0 0 1 1 1 0 Somatotropin hormone family DUF883 PF05957.13 CCM06017.1 - 0.029 15.0 5.2 3 8.5 0.4 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF3437 PF11919.8 CCM06017.1 - 0.058 13.3 0.4 0.21 11.5 0.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3437) Prominin PF05478.11 CCM06017.1 - 0.059 11.3 2.2 0.1 10.5 2.2 1.3 1 0 0 1 1 1 0 Prominin ApoLp-III PF07464.11 CCM06017.1 - 0.069 13.3 7.1 0.086 12.9 1.7 2.8 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) PIN_8 PF18476.1 CCM06017.1 - 0.13 12.1 2.0 0.38 10.6 1.5 1.9 1 1 1 2 2 2 0 PIN like domain Phasin PF05597.11 CCM06017.1 - 0.33 11.0 3.5 11 6.1 0.1 2.9 2 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Baculo_PEP_C PF04513.12 CCM06017.1 - 0.67 10.0 11.3 0.11 12.6 1.3 3.2 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 CCM06017.1 - 0.75 10.4 3.2 35 5.0 2.1 3.3 1 1 1 2 2 2 0 YtxH-like protein COesterase PF00135.28 CCM06018.1 - 3.5e-51 174.6 0.0 5.5e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM06018.1 - 9.6e-07 28.9 0.1 2.2e-06 27.7 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold F-box-like PF12937.7 CCM06019.1 - 5.5e-07 29.4 0.2 1.5e-06 28.0 0.2 1.8 1 0 0 1 1 1 1 F-box-like Polyketide_cyc2 PF10604.9 CCM06020.1 - 9.6e-07 29.2 0.2 0.00012 22.3 0.0 2.1 2 0 0 2 2 2 2 Polyketide cyclase / dehydrase and lipid transport MFS_5 PF05631.14 CCM06022.1 - 3.5e-56 190.6 4.2 5.7e-56 189.9 4.2 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 CCM06022.1 - 1.2e-16 60.6 17.6 1.2e-16 60.6 17.6 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2615 PF11027.8 CCM06022.1 - 0.083 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) YjeF_N PF03853.15 CCM06022.1 - 0.085 12.7 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus PTP_tm PF18861.1 CCM06022.1 - 0.11 12.5 0.3 0.28 11.2 0.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Amnionless PF14828.6 CCM06022.1 - 0.22 10.3 0.0 0.34 9.7 0.0 1.2 1 0 0 1 1 1 0 Amnionless Sec23_trunk PF04811.15 CCM06023.1 - 4.3e-74 249.1 0.0 6.7e-74 248.5 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CCM06023.1 - 1.4e-28 99.5 0.3 2.9e-28 98.5 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CCM06023.1 - 7.9e-26 89.9 0.1 2e-25 88.6 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CCM06023.1 - 7.9e-16 57.8 7.0 1.5e-15 56.9 7.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CCM06023.1 - 2.5e-13 49.7 0.0 8.7e-13 48.0 0.0 1.9 2 0 0 2 2 2 1 Gelsolin repeat Oxidored_FMN PF00724.20 CCM06024.1 - 1.3e-67 228.5 0.0 1.6e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Glycos_transf_1 PF00534.20 CCM06026.1 - 5.5e-20 71.6 0.0 1.5e-19 70.2 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CCM06026.1 - 1.2e-12 48.5 0.0 2.1e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CCM06026.1 - 4.2e-05 23.8 0.0 0.0001 22.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 EI24 PF07264.11 CCM06027.1 - 6.4e-32 111.2 12.6 8.5e-32 110.8 12.6 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) tRNA_int_endo PF01974.17 CCM06028.1 - 5.4e-15 55.2 0.0 1.1e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain FAM199X PF15814.5 CCM06028.1 - 5 6.1 9.3 0.29 10.1 3.2 1.8 2 0 0 2 2 2 0 Protein family FAM199X DUF1682 PF07946.14 CCM06028.1 - 6.3 5.9 6.6 8.7 5.5 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Rhodanese PF00581.20 CCM06029.1 - 1.7e-13 51.0 0.0 3.7e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Pox_MCEL PF03291.16 CCM06030.1 - 5.5e-80 269.0 0.0 3e-79 266.6 0.0 1.9 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 CCM06030.1 - 1.3e-13 51.5 0.0 2.4e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM06030.1 - 6.8e-10 39.6 0.0 1.5e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM06030.1 - 7.6e-09 36.1 0.0 1.5e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM06030.1 - 9.6e-09 35.2 0.0 1.6e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM06030.1 - 2.1e-07 30.9 0.0 3.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CCM06030.1 - 0.0038 16.4 0.0 0.0063 15.7 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Imm51 PF15595.6 CCM06031.1 - 0.038 13.9 0.1 0.087 12.8 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 51 Dynamin_N PF00350.23 CCM06033.1 - 5.5e-27 94.9 0.0 1e-26 94.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CCM06033.1 - 2.1e-21 76.4 0.0 1.2e-20 73.9 0.0 2.0 1 1 0 1 1 1 1 Dynamin central region GED PF02212.18 CCM06033.1 - 4.5e-06 26.7 0.2 0.00011 22.3 0.0 2.8 3 0 0 3 3 3 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CCM06033.1 - 0.00028 20.9 0.0 0.0022 18.1 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 CCM06033.1 - 0.015 15.0 0.2 0.029 14.1 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CCM06033.1 - 0.031 14.7 0.2 0.33 11.3 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.27 CCM06033.1 - 0.046 14.2 0.0 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_15 PF13175.6 CCM06033.1 - 0.12 12.1 0.1 0.27 10.9 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain DcpS_C PF11969.8 CCM06033.1 - 0.13 12.8 0.3 0.39 11.2 0.1 1.9 2 0 0 2 2 2 0 Scavenger mRNA decapping enzyme C-term binding GTP_EFTU PF00009.27 CCM06033.1 - 0.13 11.8 0.0 2.7 7.5 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Ceramidase_alk PF04734.13 CCM06034.1 - 7.8e-216 717.6 0.0 9.1e-216 717.4 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 CCM06034.1 - 2.3e-54 183.7 0.0 3.6e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Na_trans_assoc PF06512.13 CCM06035.1 - 4.4e-05 23.9 0.0 0.00014 22.2 0.0 1.7 1 1 0 1 1 1 1 Sodium ion transport-associated Sporozoite_P67 PF05642.11 CCM06035.1 - 0.0082 14.3 10.1 0.089 10.9 0.1 2.1 2 0 0 2 2 2 2 Sporozoite P67 surface antigen TFIIA PF03153.13 CCM06035.1 - 0.033 14.2 5.9 0.057 13.4 5.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med8 PF10232.9 CCM06035.1 - 0.13 11.9 4.4 5.3 6.6 3.2 2.3 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 eIF-3c_N PF05470.12 CCM06035.1 - 0.14 10.4 2.2 0.24 9.6 2.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Afi1 PF07792.12 CCM06035.1 - 0.34 11.4 7.2 1.8 9.0 3.5 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Myc_N PF01056.18 CCM06035.1 - 0.36 10.7 11.4 0.052 13.4 7.1 1.7 2 0 0 2 2 2 0 Myc amino-terminal region DUF4050 PF13259.6 CCM06035.1 - 0.72 10.1 8.0 0.16 12.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) TFIIF_alpha PF05793.12 CCM06035.1 - 1.5 7.4 22.4 0.076 11.6 11.8 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2052 PF09747.9 CCM06035.1 - 2.4 8.2 18.6 0.86 9.7 13.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Radial_spoke PF04712.12 CCM06035.1 - 3.4 6.5 19.6 0.59 9.0 16.0 1.4 2 0 0 2 2 2 0 Radial spokehead-like protein DUF3824 PF12868.7 CCM06035.1 - 4.1 8.1 11.8 0.19 12.4 0.5 2.6 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) FAM176 PF14851.6 CCM06035.1 - 4.6 6.9 13.1 5 6.8 8.3 2.3 2 0 0 2 2 2 0 FAM176 family BUD22 PF09073.10 CCM06035.1 - 4.9 6.4 18.5 0.72 9.1 10.7 2.2 2 0 0 2 2 2 0 BUD22 FlxA PF14282.6 CCM06035.1 - 5.4 7.1 12.4 0.18 11.8 5.8 1.8 2 0 0 2 2 2 0 FlxA-like protein Nop14 PF04147.12 CCM06035.1 - 7.1 4.7 19.1 0.22 9.7 12.4 1.7 2 0 0 2 2 2 0 Nop14-like family His_Phos_2 PF00328.22 CCM06037.1 - 0.0034 16.8 0.0 0.0085 15.5 0.0 1.6 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 2) SRP_TPR_like PF17004.5 CCM06038.1 - 1.2e-12 47.9 0.1 1.7e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 Putative TPR-like repeat SRP72 PF08492.12 CCM06038.1 - 1.6e-07 31.6 0.2 1.6e-07 31.6 0.2 2.3 2 0 0 2 2 2 1 SRP72 RNA-binding domain ANAPC3 PF12895.7 CCM06038.1 - 2.9e-07 30.6 0.6 0.00018 21.7 0.1 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCM06038.1 - 2e-05 25.0 0.7 0.00027 21.4 0.0 2.7 1 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CCM06038.1 - 0.0057 16.8 0.1 0.092 12.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 CCM06038.1 - 0.017 14.3 0.1 0.2 10.9 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCM06038.1 - 0.018 15.1 0.4 21 5.6 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CCM06038.1 - 0.1 13.5 0.1 7 7.8 0.0 3.0 2 2 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CCM06038.1 - 0.27 11.5 1.6 1.4 9.3 0.6 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Pinin_SDK_memA PF04696.13 CCM06039.1 - 1.3e-13 51.2 23.8 2.1e-12 47.2 11.4 3.2 3 0 0 3 3 3 2 pinin/SDK/memA/ protein conserved region DUF1640 PF07798.11 CCM06039.1 - 0.0037 17.3 0.3 0.0037 17.3 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) PAC1 PF16094.5 CCM06039.1 - 0.17 11.0 3.3 0.15 11.2 0.2 2.0 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 Vfa1 PF08432.10 CCM06039.1 - 0.91 9.8 18.8 0.51 10.6 8.3 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Snf7 PF03357.21 CCM06040.1 - 1.1e-35 122.7 8.9 1.1e-35 122.7 8.9 2.2 1 1 1 2 2 2 1 Snf7 Tox-REase-2 PF15646.6 CCM06040.1 - 0.028 14.6 0.9 0.51 10.5 0.2 2.8 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 2 DUF1195 PF06708.11 CCM06040.1 - 0.17 11.6 1.1 0.9 9.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1195) DUF3490 PF11995.8 CCM06040.1 - 0.78 9.5 2.9 7 6.5 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3490) DRIM PF07539.12 CCM06042.1 - 1.3e-180 601.8 6.9 1.3e-180 601.8 6.9 4.6 4 2 0 4 4 4 2 Down-regulated in metastasis DUF4042 PF13251.6 CCM06042.1 - 0.28 10.9 3.2 0.48 10.1 0.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) CTK3_C PF12350.8 CCM06043.1 - 4.2e-24 84.5 1.2 4.2e-24 84.5 1.2 2.3 3 0 0 3 3 3 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.8 CCM06043.1 - 4.3e-22 78.4 0.0 8.1e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 AAA_12 PF13087.6 CCM06043.1 - 2.9e-21 76.0 0.4 1.3e-20 73.9 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCM06043.1 - 4.1e-19 69.4 0.8 1.9e-08 34.4 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 CCM06043.1 - 3.7e-18 65.9 0.0 8.6e-17 61.5 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM06043.1 - 1.4e-12 48.1 0.0 3.8e-12 46.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCM06043.1 - 0.0013 19.2 0.0 0.0034 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Viral_helicase1 PF01443.18 CCM06043.1 - 0.0051 16.6 0.5 1.5 8.5 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 CCM06043.1 - 0.022 14.2 0.0 0.12 11.8 0.0 2.0 1 1 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 CCM06043.1 - 0.026 14.8 0.0 0.72 10.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CCM06043.1 - 0.051 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 CCM06043.1 - 0.064 12.3 0.0 0.17 10.9 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Helicase_RecD PF05127.14 CCM06043.1 - 0.1 12.5 0.0 4.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Helicase KTI12 PF08433.10 CCM06043.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 GMC_oxred_N PF00732.19 CCM06044.1 - 1.8e-58 198.3 0.0 2.4e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM06044.1 - 3.1e-35 121.8 0.0 6.8e-35 120.7 0.0 1.6 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCM06044.1 - 0.00016 20.9 0.6 0.18 10.9 0.0 2.5 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.6 CCM06044.1 - 0.0036 17.5 0.2 0.01 16.1 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCM06044.1 - 0.023 13.9 0.0 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 CCM06044.1 - 0.056 12.7 0.0 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CCM06044.1 - 0.076 12.0 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein GMC_oxred_N PF00732.19 CCM06045.1 - 9.3e-63 212.3 0.0 1.2e-62 212.0 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM06045.1 - 1.5e-32 113.1 0.0 2.5e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCM06045.1 - 0.0017 18.6 2.8 0.007 16.6 1.3 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CCM06045.1 - 0.0093 15.2 0.0 0.31 10.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CCM06045.1 - 0.015 14.4 1.7 2.3 7.2 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 CCM06045.1 - 0.038 13.2 0.1 0.086 12.1 0.1 1.5 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 CCM06045.1 - 0.37 10.3 3.6 0.68 9.5 0.5 2.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase FAP PF07174.11 CCM06046.1 - 0.051 13.0 8.3 0.052 13.0 8.3 1.0 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) RhoGAP PF00620.27 CCM06049.1 - 2.7e-16 59.8 0.0 4.1e-15 55.9 0.0 2.5 1 1 0 1 1 1 1 RhoGAP domain GPI-anchored PF10342.9 CCM06050.1 - 3.2e-07 31.0 0.0 3.9e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF2141 PF09912.9 CCM06050.1 - 0.18 11.8 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) Aminotran_5 PF00266.19 CCM06051.1 - 1.8e-39 135.8 0.0 2.3e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V GMC_oxred_N PF00732.19 CCM06052.1 - 4.2e-57 193.8 0.0 5.6e-57 193.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCM06052.1 - 1.1e-33 116.7 0.0 1.8e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CCM06052.1 - 0.0017 18.6 0.6 0.0041 17.3 0.6 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CCM06052.1 - 0.0023 17.1 0.8 1.8 7.6 0.5 2.5 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CCM06052.1 - 0.0025 17.1 0.0 0.31 10.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CCM06052.1 - 0.037 13.3 0.1 0.19 10.9 0.1 2.0 2 0 0 2 2 2 0 Thi4 family PS_Dcarbxylase PF02666.15 CCM06055.1 - 2.1e-49 167.8 0.0 2.8e-49 167.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase COesterase PF00135.28 CCM06056.1 - 6.1e-72 243.1 1.4 1.2e-70 238.8 0.4 2.7 1 1 1 2 2 2 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM06056.1 - 1.4e-09 38.2 0.5 1e-08 35.3 0.4 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM06056.1 - 0.0001 21.8 0.1 0.0002 20.9 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Pterin_bind PF00809.22 CCM06058.1 - 6.8e-61 206.0 0.0 1.1e-60 205.3 0.0 1.4 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 CCM06058.1 - 1.3e-33 115.8 0.0 2.6e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 CCM06058.1 - 1.5e-31 109.2 0.0 3e-21 76.1 0.0 2.5 2 0 0 2 2 2 2 Dihydroneopterin aldolase Fibrillarin PF01269.17 CCM06058.1 - 0.15 11.2 0.1 0.25 10.4 0.1 1.2 1 0 0 1 1 1 0 Fibrillarin MGC-24 PF05283.11 CCM06059.1 - 0.0055 17.2 5.3 0.0069 16.8 5.3 1.2 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Glycoprotein PF03409.15 CCM06059.1 - 0.1 11.5 1.9 0.094 11.6 1.9 1.1 1 0 0 1 1 1 0 Transmembrane glycoprotein Macoilin PF09726.9 CCM06059.1 - 0.27 9.7 2.3 0.31 9.6 2.3 1.0 1 0 0 1 1 1 0 Macoilin family FSA_C PF10479.9 CCM06059.1 - 0.65 8.1 8.3 0.66 8.0 8.3 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Herpes_capsid PF06112.11 CCM06059.1 - 4.3 7.4 12.4 4.9 7.2 12.4 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein RAP1 PF07218.11 CCM06059.1 - 4.4 5.5 7.7 4.7 5.4 7.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SR-25 PF10500.9 CCM06059.1 - 9.3 5.8 12.4 12 5.5 12.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CFEM PF05730.11 CCM06060.1 - 5.7e-10 39.2 17.2 1.8e-09 37.6 17.2 1.9 1 0 0 1 1 1 1 CFEM domain Plasmodium_Vir PF05795.11 CCM06060.1 - 1.4 8.3 5.7 1.8 7.9 5.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RHS_repeat PF05593.14 CCM06065.1 - 2e-18 66.5 47.7 4e-06 27.2 0.5 12.5 9 3 5 14 14 14 8 RHS Repeat TcdB_toxin_midN PF12256.8 CCM06065.1 - 1.3e-05 24.7 16.6 1 8.7 0.0 7.5 7 0 0 7 7 7 3 Insecticide toxin TcdB middle/N-terminal region RHS PF03527.14 CCM06065.1 - 0.00047 19.8 0.2 0.0015 18.2 0.2 2.0 1 0 0 1 1 1 1 RHS protein VCBS PF13517.6 CCM06065.1 - 0.00062 20.3 24.1 0.0022 18.6 0.6 5.7 7 0 0 7 7 7 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CCM06065.1 - 0.021 14.9 15.4 0.065 13.4 2.6 4.0 4 0 0 4 4 4 0 FG-GAP repeat RNA_pol_A_bac PF01000.26 CCM06067.1 - 2.7e-25 88.9 0.0 4.6e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CCM06067.1 - 2.6e-19 68.4 0.0 4.5e-19 67.6 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Cyclophil_like PF04126.13 CCM06067.1 - 0.039 13.8 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 Cyclophilin-like Cpn60_TCP1 PF00118.24 CCM06070.1 - 1.4e-84 284.5 10.2 2.2e-84 283.9 10.2 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Transp_cyt_pur PF02133.15 CCM06071.1 - 5.4e-92 308.9 40.7 6.3e-92 308.6 40.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Importin_rep_4 PF18808.1 CCM06072.1 - 1.4e-18 66.9 0.0 8.9e-18 64.4 0.0 2.4 2 0 0 2 2 2 1 Importin repeat HEAT_EZ PF13513.6 CCM06072.1 - 2.5e-17 63.0 10.6 1.2e-09 38.5 0.0 8.2 7 1 1 8 8 8 2 HEAT-like repeat HEAT PF02985.22 CCM06072.1 - 7.4e-14 50.7 8.4 1.1e-06 28.4 0.0 7.3 8 0 0 8 8 7 2 HEAT repeat HEAT_2 PF13646.6 CCM06072.1 - 7e-09 36.0 11.5 0.00089 19.6 0.0 6.5 5 1 2 7 7 7 3 HEAT repeats Vac14_Fab1_bd PF12755.7 CCM06072.1 - 2.6e-08 34.4 0.1 8.3e-07 29.5 0.0 3.3 3 1 1 4 4 3 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 CCM06072.1 - 0.0002 21.3 0.3 6.5 6.6 0.0 4.6 4 1 1 5 5 5 1 Domain of unknown function (DUF3385) Cnd1 PF12717.7 CCM06072.1 - 0.00042 20.4 0.7 3 7.8 0.0 4.3 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CCM06072.1 - 0.0012 17.5 0.1 0.031 12.9 0.0 2.8 2 1 0 2 2 2 1 Adaptin N terminal region RIX1 PF08167.12 CCM06072.1 - 0.0023 17.7 4.9 0.024 14.4 0.0 4.0 4 1 0 4 4 4 1 rRNA processing/ribosome biogenesis DUF4042 PF13251.6 CCM06072.1 - 0.024 14.4 1.1 1.8 8.2 0.0 3.8 3 2 0 3 3 3 0 Domain of unknown function (DUF4042) MMS19_C PF12460.8 CCM06072.1 - 0.035 13.2 0.2 0.035 13.2 0.2 3.4 4 1 0 4 4 4 0 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.9 CCM06072.1 - 0.053 13.7 1.3 2.1 8.6 0.0 3.5 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 CCM06072.1 - 0.13 11.4 4.8 0.3 10.2 0.0 3.5 4 1 1 5 5 5 0 Nuclear condensing complex subunits, C-term domain FAD_binding_3 PF01494.19 CCM06073.1 - 1.9e-21 76.7 0.1 9e-21 74.5 0.1 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM06073.1 - 6.2e-07 28.9 0.9 2.2e-06 27.1 0.1 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM06073.1 - 7.8e-06 26.0 0.6 2e-05 24.7 0.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCM06073.1 - 4.1e-05 24.0 0.5 0.016 15.8 0.1 3.3 4 0 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM06073.1 - 0.00026 20.7 5.0 0.001 18.8 3.9 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CCM06073.1 - 0.00033 19.6 1.6 0.043 12.7 1.4 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.12 CCM06073.1 - 0.00054 19.1 1.1 0.59 9.1 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein SE PF08491.10 CCM06073.1 - 0.0024 17.0 0.0 0.0036 16.4 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_2 PF00890.24 CCM06073.1 - 0.0037 16.4 5.2 0.0059 15.7 5.2 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 CCM06073.1 - 0.013 14.6 0.2 0.017 14.2 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Rossmann-like PF10727.9 CCM06073.1 - 0.014 15.3 0.3 0.028 14.3 0.3 1.4 1 0 0 1 1 1 0 Rossmann-like domain FAD_oxidored PF12831.7 CCM06073.1 - 0.027 13.8 2.1 0.046 13.1 2.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCM06073.1 - 0.043 13.1 0.9 0.8 8.9 0.5 2.5 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 CCM06073.1 - 0.069 12.4 0.3 0.14 11.4 0.3 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CCM06073.1 - 0.12 11.6 0.4 0.19 11.0 0.4 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CCM06073.1 - 0.14 12.1 0.3 0.24 11.2 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 CCM06073.1 - 0.19 11.0 0.3 0.6 9.4 0.4 1.6 2 0 0 2 2 2 0 ThiF family HI0933_like PF03486.14 CCM06073.1 - 0.22 10.2 1.0 1.1 7.9 1.6 1.7 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.21 CCM06073.1 - 0.24 10.6 1.1 0.43 9.8 1.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PAH PF02671.21 CCM06074.1 - 1.9e-19 69.5 0.0 4e-19 68.5 0.0 1.6 1 1 1 2 2 2 1 Paired amphipathic helix repeat CN_hydrolase PF00795.22 CCM06076.1 - 1.3e-54 185.3 0.0 1.5e-54 185.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DAGK_cat PF00781.24 CCM06077.1 - 1.2e-17 63.7 0.0 2e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain ADK PF00406.22 CCM06078.1 - 7.6e-46 155.9 0.2 1.7e-45 154.8 0.2 1.6 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CCM06078.1 - 8e-33 113.7 0.2 1.4e-32 113.0 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCM06078.1 - 8.7e-08 32.8 0.0 1.9e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CCM06078.1 - 2.8e-06 27.1 1.9 3.2e-05 23.7 1.9 2.2 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 CCM06078.1 - 5.4e-05 23.4 0.0 0.00018 21.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain F-box PF00646.33 CCM06078.1 - 0.00011 22.0 0.0 0.00036 20.3 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ploopntkinase3 PF18751.1 CCM06078.1 - 0.056 13.4 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 F-box-like PF12937.7 CCM06078.1 - 0.08 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 F-box-like SRP54 PF00448.22 CCM06078.1 - 0.17 11.5 0.2 4.5 6.9 0.0 2.8 3 1 0 3 3 3 0 SRP54-type protein, GTPase domain DnaJ_C PF01556.18 CCM06079.1 - 1.9e-39 135.1 0.9 2.8e-39 134.6 0.9 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCM06079.1 - 4e-20 71.7 1.1 6.6e-20 71.0 1.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCM06079.1 - 1.2e-16 60.8 20.6 2.4e-16 59.8 20.6 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCM06079.1 - 0.056 13.4 15.7 0.08 12.9 3.2 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein WD40 PF00400.32 CCM06079.1 - 0.96 10.4 5.9 1.9 9.5 0.1 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat COG4 PF08318.12 CCM06080.1 - 7.3e-92 308.0 0.0 1.2e-91 307.3 0.0 1.3 1 0 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.13 CCM06080.1 - 0.034 13.0 0.6 0.088 11.7 0.0 1.9 2 1 0 2 2 2 0 RINT-1 / TIP-1 family Pkip-1 PF06878.11 CCM06080.1 - 0.049 13.7 0.0 0.3 11.2 0.0 2.3 2 0 0 2 2 2 0 Pkip-1 protein Ras PF00071.22 CCM06081.1 - 2.2e-52 176.9 0.0 2.6e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM06081.1 - 1.6e-21 76.8 0.0 2.2e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM06081.1 - 1.1e-07 31.5 0.0 2.3e-07 30.4 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCM06081.1 - 0.0029 17.5 0.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 CCM06081.1 - 0.14 11.4 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region F-box-like PF12937.7 CCM06082.1 - 0.026 14.4 0.4 0.026 14.4 0.4 3.1 4 0 0 4 4 4 0 F-box-like F-box-like PF12937.7 CCM06085.1 - 0.0023 17.8 0.1 0.0069 16.3 0.1 1.8 1 0 0 1 1 1 1 F-box-like FAD_binding_3 PF01494.19 CCM06086.1 - 0.0013 18.1 0.0 0.0063 15.8 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain PRP1_N PF06424.12 CCM06086.1 - 0.056 13.8 0.6 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal F-box-like PF12937.7 CCM06087.1 - 0.0014 18.5 0.0 0.0042 16.9 0.0 1.9 1 0 0 1 1 1 1 F-box-like Mis14 PF08641.12 CCM06089.1 - 1.9e-06 28.2 4.4 2.3e-06 28.0 3.0 1.9 2 1 0 2 2 2 1 Kinetochore protein Mis14 like Spc7 PF08317.11 CCM06089.1 - 0.13 11.2 5.9 0.18 10.6 5.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Gar1 PF04410.14 CCM06090.1 - 7.4e-37 126.5 0.0 1.2e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region AAA PF00004.29 CCM06091.1 - 2e-64 215.9 0.0 3.1e-44 150.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CCM06091.1 - 3e-08 34.3 0.0 0.0062 17.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CCM06091.1 - 3.4e-08 34.0 0.1 0.0092 16.4 0.0 4.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CCM06091.1 - 3.5e-07 30.3 0.0 0.034 14.2 0.1 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CCM06091.1 - 4.6e-07 29.7 0.0 0.0051 16.6 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 CCM06091.1 - 7.2e-06 25.7 4.1 0.00021 21.0 0.3 3.8 4 0 0 4 4 3 1 AAA+ lid domain TIP49 PF06068.13 CCM06091.1 - 8.4e-06 25.2 0.1 0.05 12.8 0.0 2.7 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_33 PF13671.6 CCM06091.1 - 1.2e-05 25.5 0.0 0.29 11.3 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.6 CCM06091.1 - 6.4e-05 22.6 0.3 0.0026 17.3 0.1 3.1 3 1 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 CCM06091.1 - 0.00019 21.8 0.0 0.081 13.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 CCM06091.1 - 0.00021 21.6 0.2 0.034 14.4 0.1 3.2 2 1 1 3 3 3 1 AAA domain TsaE PF02367.17 CCM06091.1 - 0.00023 21.1 0.0 0.16 11.9 0.0 2.8 3 0 0 3 3 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 CCM06091.1 - 0.00025 20.5 0.1 0.044 13.2 0.1 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CCM06091.1 - 0.00031 21.0 0.0 0.36 11.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 CCM06091.1 - 0.00034 20.4 0.0 0.0074 16.0 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 CCM06091.1 - 0.00045 20.1 0.0 0.84 9.5 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CCM06091.1 - 0.0006 19.5 0.0 1.5 8.5 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 CCM06091.1 - 0.0012 18.3 0.0 0.0053 16.1 0.0 2.0 2 0 0 2 2 2 1 KaiC AAA_2 PF07724.14 CCM06091.1 - 0.0021 18.2 0.0 0.033 14.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 CCM06091.1 - 0.0023 17.7 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.10 CCM06091.1 - 0.0053 16.7 0.0 0.32 11.0 0.0 2.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain NACHT PF05729.12 CCM06091.1 - 0.013 15.5 0.1 2.2 8.1 0.0 2.9 3 0 0 3 3 2 0 NACHT domain NB-ARC PF00931.22 CCM06091.1 - 0.013 14.7 0.0 6.7 5.8 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain AAA_7 PF12775.7 CCM06091.1 - 0.016 14.7 0.0 0.21 11.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 CCM06091.1 - 0.016 14.3 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 CCM06091.1 - 0.022 15.2 0.0 9.4 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 CCM06091.1 - 0.031 14.4 0.0 7 6.8 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 CCM06091.1 - 0.031 14.2 0.0 9.7 6.1 0.0 2.4 2 0 0 2 2 2 0 NTPase Molydop_binding PF01568.21 CCM06091.1 - 0.057 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain PhoH PF02562.16 CCM06091.1 - 0.057 12.9 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 CCM06091.1 - 0.12 12.2 0.0 2.4 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CCM06091.1 - 0.13 12.0 0.1 4.8 6.9 0.1 2.9 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 CCM06091.1 - 0.13 12.6 0.2 5.8 7.2 0.1 2.9 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 CCM06091.1 - 0.16 11.1 0.0 0.88 8.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 CCM06091.1 - 0.2 11.7 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoD PF09423.10 CCM06092.1 - 2.1e-33 115.8 0.1 5.5e-33 114.4 0.1 1.6 1 1 0 1 1 1 1 PhoD-like phosphatase Pur_ac_phosph_N PF16656.5 CCM06092.1 - 0.00061 20.3 0.1 0.0021 18.6 0.1 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 CCM06092.1 - 0.0017 18.9 0.1 0.0053 17.3 0.1 1.8 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain DUF572 PF04502.13 CCM06093.1 - 7.5e-81 272.3 7.9 8.8e-81 272.1 7.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-FCS PF06467.14 CCM06093.1 - 0.015 15.2 0.9 0.68 9.9 0.1 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif eIF3_subunit PF08597.10 CCM06093.1 - 7.5 6.4 15.2 1.5 8.7 11.5 1.5 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF1690 PF07956.11 CCM06094.1 - 2.2e-38 131.8 0.6 4.1e-38 130.9 0.6 1.5 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) HA2 PF04408.23 CCM06094.1 - 2.9e-16 59.7 0.0 7.6e-16 58.3 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCM06094.1 - 6.6e-16 58.6 0.0 1.4e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CCM06094.1 - 2.2e-12 47.2 0.0 4.3e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 CCM06094.1 - 1.4e-06 28.2 0.0 6e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCM06094.1 - 6.4e-06 26.5 0.0 2.2e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCM06094.1 - 0.0014 18.4 0.0 0.0034 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCM06094.1 - 0.0027 18.0 0.0 0.0066 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CCM06094.1 - 0.0043 16.2 0.0 0.0081 15.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF737 PF05300.11 CCM06094.1 - 0.05 14.0 3.0 0.086 13.2 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF737) LUC7 PF03194.15 CCM06094.1 - 0.053 13.2 4.1 0.082 12.6 4.1 1.2 1 0 0 1 1 1 0 LUC7 N_terminus Rootletin PF15035.6 CCM06094.1 - 0.12 12.4 2.6 0.22 11.5 2.6 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion AAA_14 PF13173.6 CCM06094.1 - 0.13 12.3 0.1 2.4 8.2 0.1 2.4 1 1 0 1 1 1 0 AAA domain Atg14 PF10186.9 CCM06094.1 - 0.16 11.0 1.6 0.27 10.3 1.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4381 PF14316.6 CCM06095.1 - 0.049 13.9 0.2 0.11 12.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) CYYR1 PF10873.8 CCM06095.1 - 0.3 11.5 1.9 0.58 10.6 0.0 2.3 2 1 1 3 3 3 0 Cysteine and tyrosine-rich protein 1 Myb_Cef PF11831.8 CCM06096.1 - 9.2e-58 195.6 4.5 9.2e-58 195.6 4.5 3.1 4 0 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 CCM06096.1 - 3.6e-21 75.1 5.5 9.4e-11 41.7 1.3 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CCM06096.1 - 6.1e-18 64.8 6.5 3.2e-12 46.5 2.8 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain APG6_N PF17675.1 CCM06096.1 - 0.0035 17.9 4.9 0.0035 17.9 4.9 4.4 4 1 0 4 4 4 1 Apg6 coiled-coil region DUF3499 PF12005.8 CCM06096.1 - 0.83 10.3 0.0 0.83 10.3 0.0 3.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3499) DUF2340 PF10209.9 CCM06097.1 - 1.7e-51 173.7 0.5 2e-51 173.5 0.5 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Blt1 PF12754.7 CCM06097.1 - 0.0061 16.9 0.1 0.0072 16.7 0.1 1.2 1 0 0 1 1 1 1 Blt1 N-terminal domain Ubiquitin_4 PF18036.1 CCM06097.1 - 0.068 13.2 0.8 0.74 9.9 0.1 2.5 1 1 1 2 2 2 0 Ubiquitin-like domain Glyco_hydro_3_C PF01915.22 CCM06098.1 - 1e-56 192.2 0.0 1.6e-56 191.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CCM06098.1 - 9e-39 133.7 0.0 1.6e-38 132.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CCM06098.1 - 2.3e-22 78.9 0.5 4.6e-22 77.9 0.5 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 CCM06098.1 - 3.3e-13 49.7 0.0 5.3e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 CCM06098.1 - 0.0051 17.2 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 GLEYA domain PIG-S PF10510.9 CCM06098.1 - 0.2 10.5 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Myosin_head PF00063.21 CCM06099.1 - 9.7e-256 850.3 0.0 1.6e-255 849.6 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 CCM06099.1 - 9.8e-27 93.3 1.0 9.8e-27 93.3 1.0 3.1 3 0 0 3 3 3 1 DIL domain IQ PF00612.27 CCM06099.1 - 3.3e-13 48.2 33.3 0.004 16.8 0.8 7.1 6 0 0 6 6 6 5 IQ calmodulin-binding motif DUF812 PF05667.11 CCM06099.1 - 0.0068 15.4 14.9 0.011 14.6 14.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) AAA_22 PF13401.6 CCM06099.1 - 0.012 15.9 3.2 0.04 14.2 0.0 3.1 2 1 0 2 2 2 0 AAA domain BET PF17035.5 CCM06099.1 - 0.037 14.2 2.1 6.3 7.1 0.0 3.5 3 0 0 3 3 3 0 Bromodomain extra-terminal - transcription regulation Myosin_N PF02736.19 CCM06099.1 - 0.045 13.6 0.2 0.098 12.5 0.2 1.6 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 CCM06099.1 - 0.14 12.6 0.0 0.14 12.6 0.0 3.0 2 1 0 2 2 1 0 AAA ATPase domain UPF0242 PF06785.11 CCM06099.1 - 0.45 10.6 17.5 1.3 9.1 17.5 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ABC_tran PF00005.27 CCM06099.1 - 1.3 9.5 4.5 4.4 7.8 0.0 2.8 2 0 0 2 2 2 0 ABC transporter DUF724 PF05266.14 CCM06099.1 - 2.6 7.8 24.1 4.1 7.2 2.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Acetyltransf_16 PF05301.11 CCM06099.1 - 4.6 7.0 7.0 4.5 7.0 4.5 2.1 1 1 1 2 2 2 0 GNAT acetyltransferase, Mec-17 Fe-ADH PF00465.19 CCM06102.1 - 1.4e-56 191.9 1.6 1.6e-56 191.7 1.6 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCM06102.1 - 6.1e-32 111.3 0.2 7.7e-32 110.9 0.2 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 CCM06102.1 - 6.3e-05 22.3 0.7 0.0016 17.7 0.7 2.6 1 1 0 1 1 1 1 3-dehydroquinate synthase PFK PF00365.20 CCM06102.1 - 0.039 13.3 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphofructokinase S-methyl_trans PF02574.16 CCM06103.1 - 4.7e-54 184.0 0.0 5.8e-54 183.7 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Glucosamine_iso PF01182.20 CCM06104.1 - 5.7e-19 68.9 0.0 9.5e-19 68.2 0.0 1.4 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase LRR_8 PF13855.6 CCM06105.1 - 2.4e-43 145.7 55.3 8.7e-15 54.2 4.6 10.9 6 3 5 11 11 11 9 Leucine rich repeat PP2C PF00481.21 CCM06105.1 - 1.7e-40 139.3 0.0 2.9e-40 138.5 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 CCM06105.1 - 3.7e-38 128.9 57.6 4.1e-07 30.2 0.9 12.5 6 2 10 17 17 17 14 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 CCM06105.1 - 1.3e-23 83.6 0.0 2.5e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 CCM06105.1 - 5.8e-07 29.2 17.8 0.34 10.4 0.2 5.9 3 2 3 6 6 6 4 Leucine-rich repeat RA PF00788.23 CCM06105.1 - 0.0094 16.6 0.0 0.021 15.5 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain LRR_5 PF13306.6 CCM06105.1 - 0.03 14.3 0.1 4.2 7.3 0.1 2.9 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CCM06105.1 - 2.5 9.0 62.4 1.2 10.0 0.2 16.3 17 1 0 17 17 17 0 Leucine Rich Repeat Acyltransferase PF01553.21 CCM06106.1 - 1.3e-18 66.9 0.0 2.4e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase DUF3112 PF11309.8 CCM06106.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) FA_desaturase PF00487.24 CCM06106.1 - 0.096 12.5 4.5 0.23 11.2 4.5 1.6 1 0 0 1 1 1 0 Fatty acid desaturase SPC22 PF04573.12 CCM06107.1 - 9.5e-46 155.4 0.3 3.7e-36 124.2 0.0 2.0 2 0 0 2 2 2 2 Signal peptidase subunit Zn_clus PF00172.18 CCM06108.1 - 0.00023 21.2 9.3 0.00048 20.2 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mg_trans_NIPA PF05653.14 CCM06109.1 - 4.9e-82 275.4 32.5 7e-82 274.8 32.5 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CCM06109.1 - 4.4e-07 30.1 7.1 4.4e-07 30.1 7.1 3.5 3 1 0 3 3 3 2 EamA-like transporter family AAA_16 PF13191.6 CCM06110.1 - 0.00044 20.7 0.3 0.0015 18.9 0.0 1.9 2 1 1 3 3 3 1 AAA ATPase domain NB-ARC PF00931.22 CCM06110.1 - 0.015 14.5 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain APS_kinase PF01583.20 CCM06110.1 - 0.032 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase NACHT PF05729.12 CCM06110.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain Torsin PF06309.11 CCM06110.1 - 0.099 12.8 0.0 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 Torsin NACHT PF05729.12 CCM06111.1 - 0.016 15.1 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 NACHT domain WD40 PF00400.32 CCM06113.1 - 2.4e-35 119.9 14.4 1e-09 38.9 0.4 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06113.1 - 9.8e-10 38.6 0.5 0.035 14.4 0.0 3.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCM06113.1 - 0.0044 17.5 0.0 10 6.8 0.0 4.0 4 0 0 4 4 4 1 PQQ-like domain PD40 PF07676.12 CCM06113.1 - 0.0045 16.9 0.5 6.8 6.8 0.0 4.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Peptidase_S9_N PF02897.15 CCM06113.1 - 0.0082 15.0 0.1 0.67 8.7 0.0 2.5 2 1 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Nucleoporin_N PF08801.11 CCM06113.1 - 0.27 9.9 3.4 5.1 5.7 0.1 3.2 2 1 1 3 3 3 0 Nup133 N terminal like Nup160 PF11715.8 CCM06113.1 - 0.38 9.4 6.8 5 5.6 0.1 4.0 1 1 2 5 5 5 0 Nucleoporin Nup120/160 WD40 PF00400.32 CCM06114.1 - 3.2e-125 404.4 52.8 1.2e-09 38.6 0.1 14.8 13 1 1 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06114.1 - 3.5e-19 68.9 16.9 0.43 10.9 0.0 11.7 1 1 12 13 13 13 7 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CCM06114.1 - 3.3e-15 56.2 0.0 0.0078 15.6 0.0 8.1 6 2 3 9 9 9 4 WD40-like domain PD40 PF07676.12 CCM06114.1 - 1.8e-09 37.3 0.1 22 5.1 0.0 9.3 11 0 0 11 11 11 0 WD40-like Beta Propeller Repeat DUF4988 PF16378.5 CCM06114.1 - 5.7e-09 35.9 5.3 0.17 11.5 0.0 5.1 2 1 3 5 5 5 3 Domain of unknown function Nucleoporin_N PF08801.11 CCM06114.1 - 2e-08 33.5 23.6 5.6 5.6 0.0 11.4 1 1 8 10 10 10 3 Nup133 N terminal like NACHT PF05729.12 CCM06114.1 - 2.5e-07 30.7 0.0 3.2e-06 27.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain Nup160 PF11715.8 CCM06114.1 - 5.1e-07 28.7 9.3 0.94 8.0 0.0 9.9 11 1 1 12 12 12 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CCM06114.1 - 5.4e-07 28.9 0.1 4.1 6.3 0.0 6.9 2 2 4 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 CCM06114.1 - 2.8e-06 27.6 7.0 57 4.4 0.0 9.4 10 2 0 10 10 10 0 PQQ-like domain AAA_16 PF13191.6 CCM06114.1 - 1.1e-05 25.9 0.1 4.3e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain Frtz PF11768.8 CCM06114.1 - 2.3e-05 22.9 0.0 2 6.6 0.0 5.9 6 1 1 8 8 8 1 WD repeat-containing and planar cell polarity effector protein Fritz ASCH PF04266.14 CCM06114.1 - 0.022 15.3 3.6 65 4.2 0.0 5.9 6 0 0 6 6 5 0 ASCH domain Plk4_PB1 PF18190.1 CCM06114.1 - 0.085 13.0 1.4 35 4.6 0.0 5.3 6 1 1 7 7 7 0 Polo-like Kinase 4 Polo Box 1 SPDY PF03771.16 CCM06114.1 - 8.5 6.4 14.2 24 5.0 0.1 6.6 6 0 0 6 6 6 0 Domain of unknown function (DUF317) ketoacyl-synt PF00109.26 CCM06115.1 - 9.1e-55 186.0 0.4 2.2e-54 184.7 0.4 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CCM06115.1 - 2e-28 99.5 0.8 8.1e-26 91.0 0.8 2.5 1 1 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CCM06115.1 - 2.8e-28 99.3 0.0 5.6e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CCM06115.1 - 4.9e-27 94.3 0.1 1.2e-26 93.1 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CCM06115.1 - 5.8e-21 75.0 0.0 2e-20 73.3 0.0 1.8 2 0 0 2 2 2 1 Polyketide synthase dehydratase Thioesterase PF00975.20 CCM06115.1 - 4.9e-20 72.6 0.0 9.8e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Methyltransf_12 PF08242.12 CCM06115.1 - 1.3e-12 48.3 0.0 3.5e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM06115.1 - 2.2e-10 40.6 0.0 4.6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CCM06115.1 - 3.2e-10 40.2 0.1 1e-09 38.6 0.1 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CCM06115.1 - 7.2e-09 36.1 0.0 1.9e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_31 PF13847.6 CCM06115.1 - 4.6e-07 29.7 0.0 1.3e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM06115.1 - 1.4e-06 28.8 0.0 1.2e-05 25.9 0.0 2.7 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM06115.1 - 4.8e-06 27.2 0.0 2e-05 25.2 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CCM06115.1 - 1.4e-05 24.7 1.7 0.015 14.8 0.2 3.6 2 1 1 3 3 3 1 short chain dehydrogenase ACP_syn_III PF08545.10 CCM06115.1 - 0.00011 22.0 2.0 0.00071 19.4 2.0 2.5 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CCM06115.1 - 0.00048 19.6 3.4 0.00063 19.2 0.8 2.3 2 1 0 2 2 2 1 Thiolase, N-terminal domain ADH_zinc_N PF00107.26 CCM06115.1 - 0.0034 17.4 0.0 0.018 15.0 0.0 2.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM06115.1 - 0.011 16.8 0.0 0.078 14.0 0.0 2.6 2 0 0 2 2 1 0 Zinc-binding dehydrogenase Ubie_methyltran PF01209.18 CCM06115.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CCM06115.1 - 0.044 13.5 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Shikimate_DH PF01488.20 CCM06115.1 - 0.2 11.7 0.1 5 7.2 0.1 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase AAA_16 PF13191.6 CCM06117.1 - 2.4e-06 28.0 0.0 6.3e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CCM06117.1 - 5.7e-05 23.1 0.2 0.00043 20.3 0.1 2.6 2 1 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 CCM06117.1 - 0.0075 15.5 0.0 0.022 14.0 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 CCM06117.1 - 0.15 12.4 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 CCM06118.1 - 7.6e-63 212.3 0.0 4.9e-62 209.7 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06118.1 - 1.1e-35 123.2 0.0 1.8e-22 79.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CCM06118.1 - 5e-05 23.3 3.4 0.055 13.4 0.0 3.5 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CCM06118.1 - 0.00013 21.4 0.0 0.00023 20.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCM06118.1 - 0.018 13.8 0.0 0.018 13.8 0.0 2.4 3 0 0 3 3 3 0 Fungal protein kinase Spc42p PF11544.8 CCM06118.1 - 0.065 13.2 0.1 0.51 10.4 0.0 2.4 2 0 0 2 2 2 0 Spindle pole body component Spc42p Prominin PF05478.11 CCM06118.1 - 0.1 10.5 1.1 0.14 10.0 1.1 1.1 1 0 0 1 1 1 0 Prominin DUF2362 PF10154.9 CCM06118.1 - 0.2 10.5 7.5 0.32 9.9 7.5 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Sds3 PF08598.11 CCM06118.1 - 2.6 8.0 9.5 66 3.4 10.5 2.2 1 1 0 1 1 1 0 Sds3-like PKcGMP_CC PF16808.5 CCM06118.1 - 7.1 6.6 8.0 3.5 7.6 0.0 3.3 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4061 PF13270.6 CCM06118.1 - 8 6.9 8.5 2.2 8.6 1.7 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4061) DASH_Dad4 PF08650.10 CCM06119.1 - 1.5e-28 98.6 1.6 1.7e-28 98.3 1.6 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 Pneumovirus_M2 PF06436.11 CCM06119.1 - 0.021 14.3 0.0 0.025 14.1 0.0 1.1 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) DASH_Dad1 PF08649.10 CCM06119.1 - 0.036 14.2 0.1 0.046 13.9 0.1 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad1 DUF1190 PF06693.11 CCM06120.1 - 0.019 15.3 0.9 3.1 8.1 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1190) OPA3 PF07047.12 CCM06120.1 - 0.14 11.9 0.6 0.32 10.8 0.0 1.8 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) DUF4208 PF13907.6 CCM06120.1 - 0.91 10.0 3.0 31 5.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4208) DUF3959 PF13105.6 CCM06120.1 - 2.1 7.8 4.7 31 4.0 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3959) Pkinase_fungal PF17667.1 CCM06121.1 - 5.2e-54 183.6 0.0 2.1e-53 181.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 CCM06121.1 - 0.0053 16.1 0.0 0.014 14.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCM06121.1 - 0.0087 16.0 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CCM06121.1 - 0.069 12.8 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 CCM06122.1 - 2e-63 214.6 0.0 3.4e-63 213.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06122.1 - 0.012 15.0 0.0 0.17 11.3 0.0 2.3 1 1 0 1 1 1 0 Protein kinase domain RIO1 PF01163.22 CCM06122.1 - 0.022 14.3 0.1 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 RIO1 family CoA_transf_3 PF02515.17 CCM06125.1 - 9.3e-122 406.7 0.0 1.1e-121 406.5 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Transket_pyr PF02779.24 CCM06126.1 - 8.2e-66 221.1 0.0 1.3e-65 220.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 CCM06126.1 - 1.9e-59 201.1 0.0 2.9e-59 200.5 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 CCM06126.1 - 4.1e-39 133.7 0.3 7.4e-23 80.9 0.0 2.4 1 1 1 2 2 2 2 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CCM06126.1 - 2.7e-19 68.4 0.5 6.8e-19 67.2 0.5 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus RIBIOP_C PF04950.12 CCM06127.1 - 5.7e-94 314.8 3.3 6.6e-94 314.6 0.0 2.1 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CCM06127.1 - 2e-29 101.5 0.1 7.5e-29 99.6 0.0 2.1 2 0 0 2 2 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 CCM06127.1 - 2.5e-06 27.2 0.2 0.0021 17.6 0.0 2.9 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CCM06127.1 - 1.5e-05 25.4 2.4 5.9e-05 23.5 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 CCM06127.1 - 0.0002 21.3 0.0 0.00042 20.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CCM06127.1 - 0.00022 21.5 0.7 0.00058 20.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain PduV-EutP PF10662.9 CCM06127.1 - 0.00026 20.8 0.1 0.00069 19.4 0.1 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 CCM06127.1 - 0.00047 20.3 0.0 0.00047 20.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CCM06127.1 - 0.00066 18.9 0.0 0.0013 18.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 CCM06127.1 - 0.0022 18.5 0.0 0.0022 18.5 0.0 2.7 3 0 0 3 3 2 1 ABC transporter AAA PF00004.29 CCM06127.1 - 0.0025 18.3 0.1 0.008 16.6 0.1 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CCM06127.1 - 0.0031 18.1 0.8 0.025 15.1 0.0 2.9 2 1 1 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 CCM06127.1 - 0.004 17.1 0.4 0.033 14.1 0.1 2.3 1 1 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 CCM06127.1 - 0.0054 16.5 0.1 0.0054 16.5 0.1 1.8 2 0 0 2 2 1 1 AAA domain MMR_HSR1 PF01926.23 CCM06127.1 - 0.006 16.7 0.2 0.03 14.4 0.2 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 CCM06127.1 - 0.015 15.5 0.1 0.033 14.4 0.1 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 CCM06127.1 - 0.017 14.7 0.1 0.041 13.5 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Rad17 PF03215.15 CCM06127.1 - 0.018 15.0 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain MobB PF03205.14 CCM06127.1 - 0.02 14.8 0.3 0.26 11.2 0.1 2.6 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.22 CCM06127.1 - 0.023 15.1 0.0 0.089 13.2 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 CCM06127.1 - 0.023 14.7 0.0 0.064 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CCM06127.1 - 0.024 15.2 5.5 2.5 8.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CCM06127.1 - 0.033 14.1 0.1 0.082 12.8 0.1 1.7 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.6 CCM06127.1 - 0.039 13.7 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CCM06127.1 - 0.046 13.6 1.7 0.058 13.3 0.0 1.9 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 CCM06127.1 - 0.05 13.2 0.2 0.15 11.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 CCM06127.1 - 0.18 12.0 0.0 0.18 12.0 0.0 2.1 2 0 0 2 2 1 0 AAA domain ATP_bind_1 PF03029.17 CCM06127.1 - 0.4 10.4 1.5 0.41 10.4 0.0 1.8 2 0 0 2 2 1 0 Conserved hypothetical ATP binding protein SRP54 PF00448.22 CCM06127.1 - 6.7 6.3 7.5 0.18 11.4 0.2 2.1 2 0 0 2 2 1 0 SRP54-type protein, GTPase domain Cep57_MT_bd PF06657.13 CCM06128.1 - 2.6e-15 56.6 17.7 2.7e-10 40.6 0.0 4.4 4 0 0 4 4 4 3 Centrosome microtubule-binding domain of Cep57 Cep57_CLD_2 PF14197.6 CCM06128.1 - 1.2e-12 47.7 6.1 1.2e-12 47.7 6.1 3.5 2 1 1 3 3 3 1 Centrosome localisation domain of PPC89 HeLo PF14479.6 CCM06128.1 - 0.42 10.4 9.5 1.3 8.8 9.5 1.8 1 0 0 1 1 1 0 Prion-inhibition and propagation BLOC1_2 PF10046.9 CCM06128.1 - 1.5 9.2 4.8 27 5.1 0.3 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TolA_bind_tri PF16331.5 CCM06128.1 - 9.5 6.4 12.7 0.1 12.7 1.5 3.0 2 1 0 2 2 2 0 TolA binding protein trimerisation Nipped-B_C PF12830.7 CCM06130.1 - 1.2e-55 188.4 0.4 3.1e-55 187.1 0.4 1.8 1 0 0 1 1 1 1 Sister chromatid cohesion C-terminus HA2 PF04408.23 CCM06130.1 - 1.1e-18 67.5 0.0 3.8e-18 65.7 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCM06130.1 - 1.4e-14 54.3 0.0 4.1e-14 52.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cohesin_HEAT PF12765.7 CCM06130.1 - 8e-14 51.6 0.4 2.1e-12 47.1 0.5 3.0 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion AAA_22 PF13401.6 CCM06130.1 - 2.6e-06 27.7 0.1 3.2e-05 24.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain HEAT_2 PF13646.6 CCM06130.1 - 0.00021 21.6 2.4 0.021 15.2 0.1 3.9 3 1 0 3 3 2 1 HEAT repeats DEAD PF00270.29 CCM06130.1 - 0.00029 20.6 0.1 0.0011 18.8 0.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase HEAT PF02985.22 CCM06130.1 - 0.0029 17.7 0.3 3 8.3 0.0 4.5 3 0 0 3 3 3 1 HEAT repeat OB_NTP_bind PF07717.16 CCM06130.1 - 0.0077 16.6 0.0 0.022 15.1 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_30 PF13604.6 CCM06130.1 - 0.065 12.9 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CCM06130.1 - 0.092 12.1 0.1 0.22 10.8 0.1 1.6 1 0 0 1 1 1 0 KaiC DUF5472 PF17566.2 CCM06130.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5472) PhoH PF02562.16 CCM06130.1 - 0.15 11.5 0.0 0.45 9.9 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein AAA_29 PF13555.6 CCM06130.1 - 0.16 11.7 0.0 0.43 10.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain KR PF08659.10 CCM06132.1 - 1.6e-26 93.4 0.9 3.9e-23 82.3 0.0 2.8 3 0 0 3 3 3 2 KR domain NAD_binding_4 PF07993.12 CCM06132.1 - 1.6e-21 76.7 0.1 4.5e-14 52.2 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein PP-binding PF00550.25 CCM06132.1 - 1.3e-06 28.7 4.0 4.5e-06 26.9 0.2 2.9 2 0 0 2 2 2 1 Phosphopantetheine attachment site Epimerase PF01370.21 CCM06132.1 - 0.016 14.7 0.0 0.49 9.8 0.1 2.4 1 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family GSK-3_bind PF05350.12 CCM06132.1 - 0.17 11.2 0.4 0.32 10.3 0.4 1.4 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding Nnf1 PF03980.14 CCM06133.1 - 8.8e-15 55.0 3.4 1.4e-14 54.4 3.4 1.3 1 0 0 1 1 1 1 Nnf1 TMF_TATA_bd PF12325.8 CCM06133.1 - 0.032 14.5 1.8 0.032 14.5 1.8 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding CASP_C PF08172.12 CCM06133.1 - 0.038 13.3 0.8 0.051 12.9 0.8 1.2 1 0 0 1 1 1 0 CASP C terminal DUF4521 PF15021.6 CCM06133.1 - 0.062 13.2 0.2 5.8 6.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4521) KASH_CCD PF14662.6 CCM06133.1 - 0.067 13.0 4.1 0.13 12.0 4.1 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TetR_C_36 PF18598.1 CCM06133.1 - 0.093 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain ZapB PF06005.12 CCM06133.1 - 0.11 13.0 6.4 0.057 13.9 3.4 2.0 2 1 0 2 2 2 0 Cell division protein ZapB CortBP2 PF09727.9 CCM06133.1 - 0.34 10.8 6.1 0.54 10.1 6.1 1.5 1 1 0 1 1 1 0 Cortactin-binding protein-2 HALZ PF02183.18 CCM06133.1 - 0.45 10.8 2.7 2.4 8.5 2.7 2.2 1 1 0 1 1 1 0 Homeobox associated leucine zipper APG6_N PF17675.1 CCM06133.1 - 0.55 10.8 9.0 1.4 9.5 9.0 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region YabA PF06156.13 CCM06133.1 - 0.55 10.9 3.9 0.52 11.0 0.5 2.1 1 1 1 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 CCM06133.1 - 0.67 9.8 3.0 1.2 9.0 0.9 2.1 2 0 0 2 2 2 0 Septum formation initiator DUF848 PF05852.11 CCM06134.1 - 0.0094 16.1 3.0 0.0094 16.1 3.0 1.9 1 1 1 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) Lebercilin PF15619.6 CCM06134.1 - 0.11 12.1 6.1 0.63 9.7 2.6 2.4 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF2436 PF10365.9 CCM06134.1 - 0.21 11.4 0.1 0.39 10.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2436) GIT_CC PF16559.5 CCM06134.1 - 0.21 11.5 6.6 0.26 11.2 4.4 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc7 PF08317.11 CCM06134.1 - 0.23 10.3 8.6 0.54 9.1 5.0 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein CK2S PF15011.6 CCM06134.1 - 0.28 11.1 4.4 0.65 9.9 4.4 1.7 1 0 0 1 1 1 0 Casein Kinase 2 substrate MYO10_CC PF16735.5 CCM06134.1 - 0.74 10.0 3.1 2.9 8.1 3.1 2.0 1 0 0 1 1 1 0 Unconventional myosin-X coiled coil domain BRE1 PF08647.11 CCM06134.1 - 0.78 9.9 8.1 0.39 10.8 3.0 2.6 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF1664 PF07889.12 CCM06134.1 - 1.6 8.8 4.5 1.3 9.1 2.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4988 PF16378.5 CCM06134.1 - 2.5 7.7 4.4 4.2 7.0 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function TolA_bind_tri PF16331.5 CCM06134.1 - 5 7.3 10.0 36 4.5 0.0 2.8 1 1 2 3 3 3 0 TolA binding protein trimerisation HIP1_clath_bdg PF16515.5 CCM06134.1 - 8.6 7.0 12.6 0.68 10.6 7.1 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Nucleopor_Nup85 PF07575.13 CCM06137.1 - 9.5e-53 179.6 0.0 5.8e-30 104.4 0.0 2.8 2 1 0 2 2 2 2 Nup85 Nucleoporin KinB_sensor PF16767.5 CCM06137.1 - 0.31 11.5 1.3 1.2 9.6 0.0 2.5 3 0 0 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB CENP-T_C PF15511.6 CCM06138.1 - 4.4e-07 30.0 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 CCM06138.1 - 6.4e-05 23.1 0.1 9.1e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 CCM06138.1 - 0.00014 22.2 0.0 0.00018 21.8 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CCM06138.1 - 0.00098 19.4 0.1 0.0018 18.5 0.1 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CCM06138.1 - 0.0019 18.5 0.2 0.0022 18.4 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CCM06138.1 - 0.061 13.4 0.0 0.07 13.2 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 CCM06139.1 - 8.7e-50 168.5 4.0 9.7e-50 168.3 4.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CCM06139.1 - 2.7e-05 24.5 0.1 4.2e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CCM06139.1 - 5.3e-05 23.3 0.1 0.0001 22.4 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 CCM06139.1 - 0.00027 21.5 2.3 0.00034 21.2 2.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 CCM06139.1 - 0.0013 18.9 1.3 0.0014 18.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 CCM06139.1 - 0.086 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Bromodomain associated Methyltr_RsmB-F PF01189.17 CCM06140.1 - 2.5e-39 135.0 0.0 5.2e-38 130.7 0.0 2.7 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F DUF2431 PF10354.9 CCM06140.1 - 0.034 14.4 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) FtsJ PF01728.19 CCM06140.1 - 0.056 13.6 0.0 0.13 12.4 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase DUF1840 PF08895.11 CCM06140.1 - 0.79 10.1 3.4 2.1 8.7 0.1 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1840) Abhydrolase_1 PF00561.20 CCM06142.1 - 9.1e-12 45.2 0.1 2.2e-10 40.6 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM06142.1 - 1.7e-06 28.8 0.1 2.2e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM06142.1 - 0.00021 20.6 0.0 0.0086 15.4 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Asp PF00026.23 CCM06143.1 - 1.1e-66 225.4 3.2 1.3e-66 225.2 3.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM06143.1 - 2.6e-10 40.8 0.3 1.8e-07 31.6 0.3 2.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCM06143.1 - 0.18 12.5 1.9 2 9.1 0.4 3.2 2 1 0 2 2 2 0 Aspartyl protease TAS2R PF05296.13 CCM06144.1 - 0.04 13.0 2.9 0.095 11.8 2.9 1.6 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) p12I PF12233.8 CCM06144.1 - 3.7 8.1 7.6 0.47 11.0 1.0 2.6 3 0 0 3 3 3 0 Human adult T cell leukemia/lymphoma virus protein p450 PF00067.22 CCM06147.1 - 1.3e-52 179.1 0.0 7.4e-52 176.6 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 DUF4205 PF13898.6 CCM06147.1 - 0.11 11.4 0.1 0.15 10.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) Siva PF05458.12 CCM06147.1 - 0.24 11.1 0.0 0.43 10.3 0.0 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) p450 PF00067.22 CCM06148.1 - 4.3e-62 210.4 0.0 2.7e-61 207.7 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 AAA_27 PF13514.6 CCM06148.1 - 0.095 12.3 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 AAA domain SecA_DEAD PF07517.14 CCM06148.1 - 0.13 11.5 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 SecA DEAD-like domain HET PF06985.11 CCM06149.1 - 7.9e-29 100.9 0.1 1.5e-28 100.0 0.1 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) p450 PF00067.22 CCM06150.1 - 9.4e-64 215.8 0.0 2.5e-63 214.5 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCM06151.1 - 1.4e-33 116.0 0.0 1.8e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06151.1 - 7.7e-26 91.1 0.0 9.2e-26 90.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CCM06151.1 - 1.2e-06 28.6 0.0 2.3e-06 27.6 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CCM06151.1 - 7e-06 26.1 0.0 8.6e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM06151.1 - 0.00033 20.2 0.0 0.0016 17.9 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM06151.1 - 0.073 12.4 0.0 0.15 11.4 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCM06151.1 - 0.093 11.9 0.0 6.8 5.8 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein Glyco_hydro_35 PF01301.19 CCM06152.1 - 1.4e-41 143.2 0.0 1.7e-41 142.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 CCM06152.1 - 0.0008 18.9 2.2 0.0017 17.8 0.2 1.9 1 1 1 2 2 2 1 Beta-galactosidase Peptidase_M3 PF01432.20 CCM06153.1 - 3.6e-39 135.3 0.0 4.2e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 MFS_1 PF07690.16 CCM06156.1 - 8.7e-28 97.3 48.9 6.2e-24 84.6 38.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 CCM06156.1 - 0.14 11.1 22.6 0.3 10.0 4.7 3.3 2 1 1 3 3 3 0 PUCC protein adh_short_C2 PF13561.6 CCM06157.1 - 3.7e-41 141.2 0.2 6.4e-41 140.4 0.2 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CCM06157.1 - 7.4e-39 133.2 0.0 1.2e-38 132.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CCM06157.1 - 1.6e-06 28.1 0.1 3.5e-06 27.0 0.0 1.5 2 0 0 2 2 2 1 KR domain ASPRs PF17641.2 CCM06157.1 - 0.12 12.6 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Ancylostoma-associated secreted protein related Glycos_transf_3 PF00591.21 CCM06158.1 - 4.8e-75 252.4 0.0 5.9e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 CCM06158.1 - 2.2e-07 30.6 0.0 6.1e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain Ribosomal_L12_N PF16320.5 CCM06158.1 - 3.9 7.3 7.0 0.97 9.2 1.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain DUF4378 PF14309.6 CCM06159.1 - 0.046 14.1 0.0 0.046 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) Nop16 PF09420.10 CCM06160.1 - 5.9e-30 104.9 0.0 7.5e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 QCR10 PF09796.9 CCM06161.1 - 2.2e-20 72.4 0.0 2.7e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) COX7C PF02935.16 CCM06161.1 - 0.0052 17.0 0.0 0.072 13.4 0.1 1.9 2 0 0 2 2 2 1 Cytochrome c oxidase subunit VIIc UCR_6-4kD PF08997.10 CCM06161.1 - 0.092 12.7 0.9 0.22 11.5 0.9 1.7 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein HAD_2 PF13419.6 CCM06162.1 - 6.4e-05 23.1 0.0 0.00012 22.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CCM06162.1 - 0.0021 18.1 0.0 0.0035 17.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Acid_PPase PF12689.7 CCM06162.1 - 0.18 11.6 0.0 0.3 10.9 0.0 1.2 1 0 0 1 1 1 0 Acid Phosphatase Glyco_hydro_28 PF00295.17 CCM06163.1 - 1.2e-38 133.1 0.0 2.5e-38 131.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 NosD PF05048.13 CCM06163.1 - 0.0032 16.8 1.5 0.0057 16.0 1.5 1.3 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) zf-C2H2_4 PF13894.6 CCM06166.1 - 0.00034 21.2 10.5 0.019 15.8 0.8 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCM06166.1 - 0.0039 17.2 0.4 0.011 15.7 0.4 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CCM06166.1 - 0.0042 17.5 12.6 0.0049 17.3 1.4 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 CCM06166.1 - 0.0064 17.1 9.7 0.4 11.4 1.2 2.9 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2HC_2 PF13913.6 CCM06166.1 - 0.016 15.1 0.6 0.038 13.9 0.6 1.7 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2_12 PF18658.1 CCM06166.1 - 0.12 11.9 5.1 0.22 11.1 0.1 3.0 2 1 1 3 3 3 0 Zinc-finger C2H2-type DUF3328 PF11807.8 CCM06168.1 - 1.7e-10 41.1 0.2 9.1e-10 38.7 0.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) But2 PF09792.9 CCM06169.1 - 0.00022 21.6 0.0 0.00038 20.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain DUF3328 PF11807.8 CCM06170.1 - 8e-10 38.9 1.8 1.1e-09 38.4 1.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Synaptobrevin PF00957.21 CCM06172.1 - 0.042 13.6 0.0 0.06 13.2 0.0 1.2 1 0 0 1 1 1 0 Synaptobrevin p450 PF00067.22 CCM06173.1 - 9.6e-66 222.4 0.0 1.2e-65 222.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAM199X PF15814.5 CCM06174.1 - 0.12 11.4 5.8 0.16 11.0 5.8 1.1 1 0 0 1 1 1 0 Protein family FAM199X FSA_C PF10479.9 CCM06175.1 - 4.9 5.2 11.4 6.6 4.7 11.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MCU PF04678.13 CCM06176.1 - 1e-35 123.4 0.6 2.7e-35 122.0 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial calcium uniporter AA_permease_2 PF13520.6 CCM06177.1 - 1.2e-39 136.4 46.6 1.9e-39 135.7 46.6 1.3 1 0 0 1 1 1 1 Amino acid permease DIOX_N PF14226.6 CCM06178.1 - 6.2e-17 62.4 0.0 2.6e-16 60.4 0.0 2.0 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM06178.1 - 4.9e-15 55.8 0.0 1.3e-14 54.5 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CCM06179.1 - 1.4e-15 58.1 0.0 2.6e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM06179.1 - 2.4e-12 47.2 0.0 4.9e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_92N PF17678.1 CCM06181.1 - 2.6e-47 161.7 0.1 3.3e-47 161.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DUF4449 PF14613.6 CCM06183.1 - 1.6e-37 129.1 4.0 2.5e-37 128.5 2.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) p450 PF00067.22 CCM06184.1 - 5e-66 223.3 0.0 5.8e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CCM06185.1 - 1.3e-29 103.1 0.1 4.2e-24 85.1 0.0 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06185.1 - 1.2e-17 64.3 0.0 4.8e-16 59.0 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06185.1 - 4.7e-07 29.9 0.0 7.6e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM06185.1 - 3.8e-05 23.3 0.0 5.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCM06185.1 - 0.0025 17.0 0.3 0.0035 16.5 0.3 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein IQ PF00612.27 CCM06187.1 - 0.29 11.0 1.6 0.69 9.9 1.6 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ran_BP1 PF00638.18 CCM06188.1 - 4.2e-17 62.6 0.0 8.3e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 RanBP1 domain F-box-like PF12937.7 CCM06189.1 - 0.0012 18.7 2.6 0.0031 17.4 2.6 1.7 1 0 0 1 1 1 1 F-box-like adh_short PF00106.25 CCM06190.1 - 3.1e-34 118.2 0.1 1.6e-32 112.6 0.1 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06190.1 - 5.4e-21 75.2 0.2 2.4e-19 69.9 0.2 2.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06190.1 - 3e-10 40.3 0.0 5.5e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM06190.1 - 0.00061 19.3 0.3 0.0015 18.0 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CCM06190.1 - 0.042 13.0 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 CCM06190.1 - 0.081 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CCM06190.1 - 0.13 12.5 0.1 0.42 10.9 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain UL42 PF17638.2 CCM06190.1 - 0.14 12.1 1.8 0.29 11.1 1.8 1.4 1 0 0 1 1 1 0 HCMV UL42 DnaJ PF00226.31 CCM06192.1 - 3.5e-16 59.1 0.4 4e-16 58.9 0.4 1.2 1 0 0 1 1 1 1 DnaJ domain p450 PF00067.22 CCM06194.1 - 4.6e-71 239.9 0.0 6e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CCM06195.1 - 3.6e-42 144.6 42.2 3.6e-42 144.6 42.2 1.8 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM06195.1 - 2.6e-10 39.8 22.7 2.5e-07 29.9 2.6 3.7 3 1 1 4 4 4 2 Sugar (and other) transporter MFS_3 PF05977.13 CCM06195.1 - 0.0004 18.9 4.3 0.00066 18.2 4.3 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector PHF5 PF03660.14 CCM06196.1 - 1.9e-52 175.9 7.9 2.1e-52 175.7 7.9 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 CCM06196.1 - 0.038 11.9 4.8 0.042 11.7 4.8 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 CCM06196.1 - 0.42 10.7 15.0 1.6 8.8 1.8 2.9 1 1 1 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 CCM06196.1 - 2 8.8 17.7 0.37 11.1 2.7 2.6 1 1 1 2 2 2 0 C1 domain HECT PF00632.25 CCM06197.1 - 3.2e-80 269.9 0.0 4.6e-80 269.4 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Arm PF00514.23 CCM06197.1 - 0.021 14.9 2.0 0.54 10.4 0.0 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat UIM PF02809.20 CCM06197.1 - 0.037 13.9 0.4 0.18 11.8 0.4 2.3 1 0 0 1 1 1 0 Ubiquitin interaction motif Importin_rep_6 PF18829.1 CCM06197.1 - 1.1 9.5 5.0 81 3.4 5.8 2.7 2 0 0 2 2 2 0 Importin repeat 6 Aminotran_3 PF00202.21 CCM06198.1 - 7.3e-78 262.0 0.0 9.2e-78 261.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III DUF2624 PF11116.8 CCM06198.1 - 0.18 12.7 0.2 32 5.5 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2624) GCFC PF07842.12 CCM06199.1 - 2.7e-79 266.7 5.5 4e-79 266.1 5.5 1.3 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.8 CCM06199.1 - 4.1e-12 46.4 15.9 4.1e-12 46.4 15.9 2.9 2 1 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch PF01585.23 CCM06199.1 - 4.5e-12 45.7 2.4 1.5e-11 44.0 2.4 2.0 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CCM06199.1 - 1.5e-07 31.4 5.2 1.5e-06 28.2 1.1 3.1 2 1 0 2 2 2 1 G-patch domain Geminin PF07412.12 CCM06199.1 - 0.053 13.2 0.0 0.053 13.2 0.0 2.2 2 0 0 2 2 2 0 Geminin Ribosomal_S4e PF00900.20 CCM06201.1 - 6.3e-37 125.3 0.2 1.4e-36 124.3 0.2 1.6 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 CCM06201.1 - 1.9e-24 85.0 0.1 4.1e-24 84.0 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 CCM06201.1 - 4.5e-21 74.7 5.8 9.2e-21 73.7 5.8 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 CCM06201.1 - 1.9e-06 27.5 0.0 4.1e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 CCM06201.1 - 2.1e-05 24.3 4.3 7e-05 22.6 4.3 2.0 1 0 0 1 1 1 1 KOW motif Sipho_tail PF05709.11 CCM06201.1 - 0.1 12.0 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Phage tail protein E1-E2_ATPase PF00122.20 CCM06202.1 - 2.3e-24 85.9 0.0 5.1e-24 84.8 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CCM06202.1 - 1.2e-15 58.4 0.0 1.7e-09 38.3 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CCM06202.1 - 3.6e-05 23.8 0.0 8.9e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CCM06202.1 - 0.01 15.5 0.0 0.022 14.4 0.0 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CCM06202.1 - 0.057 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase An_peroxidase PF03098.15 CCM06203.1 - 3.1e-31 108.6 0.0 7.2e-22 77.7 0.0 3.1 1 1 1 2 2 2 2 Animal haem peroxidase DUF676 PF05057.14 CCM06205.1 - 1.5e-37 129.3 0.0 2.1e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 CCM06205.1 - 6.1e-05 22.9 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Palm_thioest PF02089.15 CCM06205.1 - 0.035 14.0 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Thioesterase PF00975.20 CCM06205.1 - 0.18 11.9 0.0 0.69 10.0 0.0 2.0 3 0 0 3 3 3 0 Thioesterase domain p450 PF00067.22 CCM06206.1 - 6.3e-44 150.5 0.0 7.7e-44 150.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HEAT_2 PF13646.6 CCM06206.1 - 0.071 13.5 0.2 0.52 10.7 0.3 2.1 2 0 0 2 2 2 0 HEAT repeats Paramyxo_C PF01692.18 CCM06206.1 - 0.19 11.1 0.0 0.38 10.1 0.0 1.4 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C NADH_B2 PF14813.6 CCM06208.1 - 5.1e-05 23.0 0.2 6.6e-05 22.6 0.2 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 RHH_5 PF07878.11 CCM06209.1 - 0.026 14.4 0.1 0.078 12.9 0.1 1.9 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 PsiA PF06952.11 CCM06209.1 - 7.5 5.7 7.4 2.4 7.3 2.7 2.2 2 0 0 2 2 2 0 PsiA protein zf-C3HC4_2 PF13923.6 CCM06210.1 - 1.9e-07 30.8 3.6 1.9e-07 30.8 3.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCM06210.1 - 4.4e-07 29.8 4.8 4.4e-07 29.8 4.8 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 CCM06210.1 - 1.4e-06 28.5 10.8 2.3e-06 27.8 3.9 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 CCM06210.1 - 1.6e-06 28.1 6.2 7.2e-06 26.1 2.8 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 CCM06210.1 - 5.8e-06 26.1 8.5 6.3e-06 26.0 4.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCM06210.1 - 1.9e-05 24.5 9.4 0.0001 22.2 3.8 2.5 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCM06210.1 - 7.1e-05 22.6 6.6 0.00014 21.6 1.7 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CCM06210.1 - 8.9e-05 22.3 7.9 0.00038 20.3 2.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) FlxA PF14282.6 CCM06210.1 - 0.0037 17.2 3.1 0.0037 17.2 3.1 2.5 3 0 0 3 3 3 1 FlxA-like protein zf-RING_6 PF14835.6 CCM06210.1 - 0.017 15.0 0.4 0.034 14.0 0.4 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Csm1_N PF18504.1 CCM06210.1 - 0.041 14.2 0.9 0.26 11.6 1.2 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain Zn_ribbon_17 PF17120.5 CCM06210.1 - 0.29 10.8 6.8 0.1 12.3 3.8 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 CCM06210.1 - 0.44 10.9 10.3 0.23 11.8 4.3 2.6 2 1 0 2 2 2 0 RING-H2 zinc finger domain CEBP_ZZ PF16366.5 CCM06210.1 - 0.46 10.7 4.6 1 9.6 2.4 2.3 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain NAM-associated PF14303.6 CCM06210.1 - 3.5 8.3 9.8 6.7 7.4 9.8 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain IBR PF01485.21 CCM06210.1 - 7 7.0 7.8 20 5.5 4.7 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain MBOAT_2 PF13813.6 CCM06211.1 - 3.1e-21 75.5 1.0 6.8e-21 74.3 1.0 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family p450 PF00067.22 CCM06212.1 - 8.6e-37 126.9 0.0 9.4e-37 126.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.32 CCM06213.1 - 0.00017 22.3 0.0 0.00091 20.0 0.0 2.4 1 0 0 1 1 1 1 WD domain, G-beta repeat Nup160 PF11715.8 CCM06213.1 - 0.1 11.3 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Pkinase PF00069.25 CCM06214.1 - 5.8e-42 143.9 0.0 1.4e-41 142.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06214.1 - 2.1e-22 79.7 0.0 1e-21 77.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCM06214.1 - 5.3e-05 22.7 0.0 8.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCM06214.1 - 0.00055 19.9 2.3 0.0012 18.8 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM06214.1 - 0.013 14.3 0.0 0.013 14.3 0.0 3.3 4 1 0 4 4 4 0 Fungal protein kinase Choline_kinase PF01633.20 CCM06214.1 - 0.2 11.2 1.5 0.67 9.5 0.0 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF1974 PF09317.11 CCM06214.1 - 0.37 10.3 7.0 0.69 9.4 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) TFIIA PF03153.13 CCM06214.1 - 5.1 7.0 15.5 9.4 6.1 15.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_MLP1_2 PF07926.12 CCM06215.1 - 9.8e-29 100.0 17.2 9.8e-29 100.0 17.2 18.3 6 4 9 17 17 17 5 TPR/MLP1/MLP2-like protein DivIC PF04977.15 CCM06215.1 - 0.00089 19.0 3.4 0.0078 16.0 0.3 24.6 18 10 10 29 29 29 4 Septum formation initiator KASH_CCD PF14662.6 CCM06215.1 - 0.0054 16.6 11.2 0.0054 16.6 11.2 15.7 5 2 7 14 14 14 2 Coiled-coil region of CCDC155 or KASH Takusan PF04822.13 CCM06215.1 - 0.0081 16.0 0.1 0.0081 16.0 0.1 11.4 12 3 2 14 14 14 1 Takusan Occludin_ELL PF07303.13 CCM06215.1 - 0.0083 16.8 1.2 0.0083 16.8 1.2 17.7 9 6 9 19 19 19 3 Occludin homology domain MtrB PF05440.12 CCM06215.1 - 8.7 6.8 12.6 26 5.3 0.0 6.5 8 0 0 8 8 8 0 Tetrahydromethanopterin S-methyltransferase subunit B adh_short PF00106.25 CCM06216.1 - 4.3e-17 62.2 0.0 6.2e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06216.1 - 5e-11 42.6 0.0 6.9e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ICMT PF04140.14 CCM06217.1 - 3.2e-11 43.5 0.0 1.9e-10 41.0 0.1 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM06217.1 - 6.9e-09 36.0 0.0 3.2e-08 33.9 0.1 1.9 2 0 0 2 2 2 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCM06217.1 - 8.5e-06 24.8 0.0 1.4e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF5317 PF17248.2 CCM06217.1 - 0.039 14.0 0.1 0.13 12.2 0.1 1.8 2 1 1 3 3 3 0 Family of unknown function (DUF5317) APH PF01636.23 CCM06218.1 - 4.4e-09 36.6 0.1 6.7e-09 36.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-C2H2 PF00096.26 CCM06219.1 - 3.7e-07 30.2 9.1 0.011 16.2 0.2 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type FOXP-CC PF16159.5 CCM06219.1 - 8.7e-05 23.1 3.5 0.0025 18.4 0.4 3.2 2 1 1 3 3 3 1 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CCM06219.1 - 0.00032 21.3 10.9 0.3 12.0 0.2 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCM06219.1 - 0.001 18.8 11.2 0.052 13.3 0.1 3.8 3 1 0 3 3 3 1 C2H2-type zinc-finger domain zf-Di19 PF05605.12 CCM06219.1 - 0.0011 19.2 5.4 0.75 10.1 1.6 2.9 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-ribbon_3 PF13248.6 CCM06219.1 - 0.0012 18.1 2.0 0.35 10.3 0.1 2.5 2 0 0 2 2 2 2 zinc-ribbon domain zf-H2C2_2 PF13465.6 CCM06219.1 - 0.0039 17.5 8.3 0.18 12.3 1.4 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 CCM06219.1 - 0.046 14.0 2.7 0.12 12.7 2.7 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-BED PF02892.15 CCM06219.1 - 0.11 12.5 1.6 2.4 8.2 0.1 2.4 2 0 0 2 2 2 0 BED zinc finger zinc_ribbon_2 PF13240.6 CCM06219.1 - 0.11 12.2 3.3 1.7 8.5 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 CCM06219.1 - 0.12 12.5 0.8 3.8 7.7 0.2 2.8 2 0 0 2 2 2 0 Zinc ribbon domain zf-met PF12874.7 CCM06219.1 - 0.12 12.8 0.5 3.5 8.2 0.0 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zinc_ribbon_9 PF14369.6 CCM06219.1 - 0.27 11.5 1.3 7.8 6.9 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon Ferric_reduct PF01794.19 CCM06220.1 - 3.7e-17 62.6 15.0 8.8e-17 61.4 15.0 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CCM06220.1 - 1.7e-10 40.9 0.0 3e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CCM06220.1 - 2.9e-10 40.5 0.0 3.3e-09 37.0 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 CCM06220.1 - 0.052 14.2 0.0 0.44 11.2 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Transketolase_C PF02780.20 CCM06220.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Transketolase, C-terminal domain adh_short PF00106.25 CCM06221.1 - 2.7e-17 62.9 0.0 3.8e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06221.1 - 8e-11 41.9 0.0 1e-10 41.6 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Amidase PF01425.21 CCM06222.1 - 3.9e-104 349.1 0.0 5.1e-104 348.7 0.0 1.1 1 0 0 1 1 1 1 Amidase Hexapep PF00132.24 CCM06223.1 - 3.2e-14 52.0 11.2 7.8e-06 25.4 0.9 3.6 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) W2 PF02020.18 CCM06223.1 - 1.1e-11 44.7 0.1 1.1e-11 44.7 0.1 3.6 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep_2 PF14602.6 CCM06223.1 - 4.5e-07 29.5 9.5 0.024 14.4 0.1 3.6 2 1 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase NTP_transferase PF00483.23 CCM06223.1 - 1.3e-06 28.2 0.0 2.1e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CCM06223.1 - 8.5e-05 23.0 0.0 0.00019 21.8 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 CCM06223.1 - 0.023 12.9 2.2 0.047 11.8 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 CCM06223.1 - 0.12 11.2 0.1 0.24 10.3 0.1 1.4 1 0 0 1 1 1 0 L-fucokinase BUD22 PF09073.10 CCM06223.1 - 2 7.7 64.2 3.8 6.7 42.5 2.2 2 0 0 2 2 2 0 BUD22 Abhydrolase_3 PF07859.13 CCM06224.1 - 2.6e-10 40.5 0.0 4.5e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCM06224.1 - 0.021 13.7 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family ABC2_membrane_3 PF12698.7 CCM06227.1 - 0.42 9.7 6.6 0.54 9.3 6.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein NS3_envE PF02723.14 CCM06227.1 - 3.6 7.7 10.4 4.2 7.5 2.4 2.3 2 0 0 2 2 2 0 Non-structural protein NS3/Small envelope protein E zinc_ribbon_15 PF17032.5 CCM06229.1 - 2.5e-06 28.1 0.3 4.2e-06 27.4 0.3 1.3 1 0 0 1 1 1 1 zinc-ribbon family Zn_Tnp_IS1595 PF12760.7 CCM06229.1 - 0.014 15.3 1.6 0.04 13.9 1.6 1.7 1 1 0 1 1 1 0 Transposase zinc-ribbon domain DUF3716 PF12511.8 CCM06229.1 - 0.014 15.4 0.3 0.022 14.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) FYVE_2 PF02318.16 CCM06229.1 - 0.29 11.4 3.4 5.9 7.1 0.1 2.1 1 1 1 2 2 2 0 FYVE-type zinc finger Asp PF00026.23 CCM06230.1 - 3.6e-48 164.6 1.0 4.5e-48 164.3 1.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM06230.1 - 6.5e-06 26.5 1.8 0.0016 18.7 1.8 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCM06230.1 - 0.012 16.2 0.4 1.2 9.8 0.2 3.2 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 CCM06230.1 - 0.15 12.7 0.3 4.6 7.9 0.1 3.0 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease Ras PF00071.22 CCM06231.1 - 1.7e-59 200.1 1.0 2.1e-59 199.7 1.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM06231.1 - 3e-30 104.9 0.6 4.5e-30 104.3 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM06231.1 - 4.6e-14 52.2 0.2 5.6e-14 52.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM06231.1 - 5.5e-06 26.1 0.2 9.9e-06 25.2 0.2 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM06231.1 - 0.001 19.0 1.1 0.0016 18.3 1.1 1.4 1 1 0 1 1 1 1 RsgA GTPase ATP_bind_1 PF03029.17 CCM06231.1 - 0.024 14.4 0.0 0.031 14.1 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 CCM06231.1 - 0.045 13.1 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region rve PF00665.26 CCM06231.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Cyclin_N PF00134.23 CCM06232.1 - 1.4e-08 34.5 0.2 8.3e-08 32.0 0.2 2.1 1 1 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 CCM06232.1 - 0.05 14.0 0.3 0.1 13.0 0.0 1.7 2 0 0 2 2 2 0 Cyclin C-terminal domain RB_B PF01857.20 CCM06232.1 - 0.11 12.6 0.1 0.43 10.6 0.1 2.0 3 0 0 3 3 3 0 Retinoblastoma-associated protein B domain SOR_SNZ PF01680.17 CCM06234.1 - 9.8e-111 368.4 6.3 1.6e-110 367.8 6.3 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 CCM06234.1 - 2e-10 40.4 3.3 3.9e-07 29.6 0.1 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 CCM06234.1 - 0.00011 21.5 0.1 0.28 10.2 0.1 2.4 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 CCM06234.1 - 0.00054 20.0 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain NMO PF03060.15 CCM06234.1 - 0.0091 15.4 3.8 0.2 11.0 0.1 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase NanE PF04131.14 CCM06234.1 - 0.022 13.9 0.2 0.44 9.7 0.0 2.3 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase HisK_sensor PF18698.1 CCM06234.1 - 0.069 13.5 0.1 0.13 12.6 0.1 1.4 1 0 0 1 1 1 0 Histidine kinase sensor domain NACHT PF05729.12 CCM06237.1 - 2.3e-06 27.6 0.6 1e-05 25.5 0.6 2.1 1 1 0 1 1 1 1 NACHT domain F-box-like PF12937.7 CCM06237.1 - 0.061 13.2 1.0 2.3 8.2 0.1 2.7 2 1 0 2 2 2 0 F-box-like GFO_IDH_MocA PF01408.22 CCM06238.1 - 3.6e-24 85.9 0.0 7.4e-24 84.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DXP_reductoisom PF02670.16 CCM06238.1 - 0.011 16.5 0.0 0.056 14.2 0.0 1.9 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase GFO_IDH_MocA_C PF02894.17 CCM06238.1 - 0.079 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.24 CCM06238.1 - 0.092 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Fungal_trans PF04082.18 CCM06239.1 - 6.1e-22 77.9 0.0 1.5e-21 76.6 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM06239.1 - 1.2e-10 41.3 3.9 2.7e-10 40.2 3.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GRIM-19 PF06212.12 CCM06240.1 - 1.2e-25 90.0 0.0 2.5e-25 88.9 0.0 1.6 1 0 0 1 1 1 1 GRIM-19 protein HMG_box_2 PF09011.10 CCM06240.1 - 4.1e-13 49.7 11.9 2.8e-06 27.8 4.9 2.6 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.19 CCM06240.1 - 5.8e-13 49.1 14.6 1.1e-07 32.1 2.5 3.0 2 1 0 2 2 2 2 HMG (high mobility group) box Pkinase PF00069.25 CCM06242.1 - 0.00042 19.8 0.0 0.00047 19.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCM06242.1 - 0.027 14.4 0.4 0.032 14.2 0.4 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM06242.1 - 0.038 12.8 0.0 0.045 12.5 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase WD40 PF00400.32 CCM06243.1 - 2.4e-57 189.6 19.8 5.4e-09 36.5 0.1 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06243.1 - 4.6e-22 78.1 0.1 0.032 14.5 0.0 7.7 1 1 7 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM06243.1 - 1.4e-16 60.4 6.2 0.0039 16.2 0.1 7.8 1 1 7 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CCM06243.1 - 6.1e-12 45.1 4.0 0.27 11.2 0.0 6.7 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CCM06243.1 - 4.6e-07 28.7 1.2 0.011 14.3 0.2 2.7 2 1 1 3 3 3 2 Cytochrome D1 heme domain Gmad1 PF10647.9 CCM06243.1 - 5.1e-06 26.4 9.1 0.0002 21.2 3.1 3.6 2 2 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain eIF2A PF08662.11 CCM06243.1 - 0.00023 21.1 0.0 2.3 8.1 0.0 3.2 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CCM06243.1 - 0.0061 15.9 0.0 0.33 10.2 0.0 2.8 2 1 2 4 4 4 1 WD40-like domain Proteasome_A_N PF10584.9 CCM06243.1 - 0.012 15.3 16.1 2.6 7.8 0.1 6.5 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature PALB2_WD40 PF16756.5 CCM06243.1 - 0.015 14.3 0.8 1.8 7.4 0.1 2.8 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF4520 PF15016.6 CCM06243.1 - 0.025 14.7 0.0 0.14 12.3 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4520) Frtz PF11768.8 CCM06243.1 - 0.17 10.2 0.0 40 2.3 0.0 2.9 1 1 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz F-box-like PF12937.7 CCM06244.1 - 2.3e-05 24.2 0.9 7.2e-05 22.6 0.9 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM06244.1 - 0.011 15.6 0.2 0.054 13.4 0.2 2.2 1 0 0 1 1 1 0 F-box domain Pkinase PF00069.25 CCM06245.1 - 0.036 13.4 0.0 0.056 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Sugar_tr PF00083.24 CCM06248.1 - 6.7e-93 312.0 19.1 2.9e-80 270.3 7.1 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCM06248.1 - 8.9e-17 61.0 40.3 1.7e-07 30.5 2.5 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily NAD_binding_4 PF07993.12 CCM06250.1 - 7.1e-28 97.5 0.0 1.3e-27 96.6 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CCM06250.1 - 3.2e-25 88.6 0.0 7e-24 84.2 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme Epimerase PF01370.21 CCM06250.1 - 2.8e-09 36.8 0.0 9.3e-09 35.1 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CCM06250.1 - 0.065 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 CCM06250.1 - 0.22 10.9 0.0 0.46 9.8 0.0 1.5 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase FGGY_N PF00370.21 CCM06251.1 - 0.00047 19.8 0.0 0.77 9.3 0.0 2.3 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Hva1_TUDOR PF11160.8 CCM06252.1 - 3.2e-17 62.4 2.4 3.8e-17 62.2 2.4 1.1 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain Methyltransf_2 PF00891.18 CCM06253.1 - 9e-21 74.1 0.1 3.1e-20 72.4 0.1 1.7 1 1 0 1 1 1 1 O-methyltransferase domain YscK PF06578.12 CCM06253.1 - 0.03 13.8 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 YOP proteins translocation protein K (YscK) OPT PF03169.15 CCM06254.1 - 4.6e-121 405.4 25.4 2.4e-120 403.1 25.4 1.8 1 1 0 1 1 1 1 OPT oligopeptide transporter protein SRP-alpha_N PF04086.13 CCM06255.1 - 7.5 6.4 15.8 10 5.9 15.8 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Mannosyl_trans2 PF04188.13 CCM06256.1 - 3.4e-53 181.6 21.4 4e-53 181.3 21.4 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) Chlorophyllase2 PF12740.7 CCM06257.1 - 0.013 14.4 0.0 0.018 14.0 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 CCM06257.1 - 0.025 14.2 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Tri3 PF07428.11 CCM06259.1 - 4.2e-20 72.0 0.0 1.2e-19 70.5 0.0 1.6 1 1 0 1 1 1 1 15-O-acetyltransferase Tri3 Abhydrolase_6 PF12697.7 CCM06260.1 - 2.1e-17 64.5 3.5 8e-09 36.4 0.2 2.1 2 0 0 2 2 2 2 Alpha/beta hydrolase family Peptidase_S32 PF05579.13 CCM06263.1 - 0.00089 18.5 0.0 0.0041 16.4 0.1 1.8 2 0 0 2 2 2 1 Equine arteritis virus serine endopeptidase S32 Peptidase_S64 PF08192.11 CCM06263.1 - 0.0057 15.2 0.3 0.017 13.7 0.0 1.7 2 0 0 2 2 2 1 Peptidase family S64 DUF1515 PF07439.11 CCM06263.1 - 0.14 12.2 0.6 0.28 11.2 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Ras PF00071.22 CCM06264.1 - 8.4e-52 175.0 0.4 1e-51 174.7 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM06264.1 - 3.5e-28 98.2 0.1 5.4e-28 97.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM06264.1 - 2.7e-10 40.0 0.1 3.4e-10 39.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CCM06264.1 - 5.5e-06 26.0 0.0 8.8e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CCM06264.1 - 0.0048 16.8 0.0 0.011 15.7 0.0 1.5 1 1 1 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 CCM06264.1 - 0.014 14.8 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RRM_1 PF00076.22 CCM06265.1 - 1.2e-12 47.5 0.1 8.4e-09 35.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCM06265.1 - 0.043 13.8 0.1 3.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif COesterase PF00135.28 CCM06269.1 - 4.2e-39 134.8 0.1 4.8e-39 134.6 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Pkinase_fungal PF17667.1 CCM06270.1 - 7.9e-39 133.6 0.0 1.9e-27 96.1 0.1 2.9 1 1 1 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 CCM06270.1 - 0.0087 15.5 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCM06270.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF5595 PF18077.1 CCM06270.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) ORF45 PF17620.2 CCM06270.1 - 0.17 11.9 0.0 0.32 11.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function Como_LCP PF02247.16 CCM06272.1 - 0.17 10.5 0.1 0.25 9.9 0.1 1.2 1 0 0 1 1 1 0 Large coat protein Dimerisation2 PF16864.5 CCM06273.1 - 2.5e-05 24.2 0.0 4.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain 2OG-FeII_Oxy_2 PF13532.6 CCM06275.1 - 2e-23 83.6 0.0 2.7e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily G-patch PF01585.23 CCM06277.1 - 2.6e-07 30.4 2.1 3.3e-07 30.1 0.1 2.3 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CCM06277.1 - 0.00063 19.8 0.1 0.00063 19.8 0.1 4.1 5 0 0 5 5 5 1 G-patch domain SR-25 PF10500.9 CCM06277.1 - 0.013 15.1 34.0 0.23 11.1 15.5 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 CCM06277.1 - 1.2 6.1 4.0 1.6 5.8 4.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CPSF100_C PF13299.6 CCM06277.1 - 3.7 7.7 15.5 0.35 11.1 4.5 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal SRP-alpha_N PF04086.13 CCM06277.1 - 5.3 6.9 33.7 2.8 7.8 10.8 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DNA_ligase_A_M PF01068.21 CCM06278.1 - 4e-51 173.6 0.1 1.1e-50 172.2 0.0 1.8 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CCM06278.1 - 1e-30 107.3 0.8 1.4e-29 103.6 0.1 2.8 2 1 0 2 2 2 1 DNA ligase N terminus BRCT_2 PF16589.5 CCM06278.1 - 2.2e-20 72.8 0.0 6.6e-09 36.1 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 CCM06278.1 - 1.7e-15 57.4 0.0 5.8e-15 55.7 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 CCM06278.1 - 1.7e-13 51.2 0.0 5.6e-13 49.5 0.0 1.9 2 0 0 2 2 2 1 RNA ligase BRCT PF00533.26 CCM06278.1 - 6.7e-08 32.8 0.0 0.00017 21.9 0.0 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CCM06278.1 - 0.015 15.6 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 CCM06278.1 - 0.051 13.5 0.0 8.7 6.4 0.0 2.6 2 0 0 2 2 2 0 twin BRCT domain DUF4073 PF13285.6 CCM06278.1 - 0.066 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4073) Leu_zip PF15294.6 CCM06278.1 - 0.076 12.5 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 Leucine zipper Forkhead PF00250.18 CCM06279.1 - 6.2e-27 93.7 0.0 1.4e-26 92.6 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain Adaptin_N PF01602.20 CCM06280.1 - 5.4e-132 441.0 6.0 6.9e-132 440.7 6.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 CCM06280.1 - 8.9e-24 83.9 0.1 2.6e-23 82.5 0.1 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 CCM06280.1 - 7.5e-07 29.3 7.3 1.2e-05 25.5 0.4 3.2 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCM06280.1 - 0.011 16.1 3.1 1.6 9.2 0.2 3.8 4 0 0 4 4 4 0 HEAT repeats HEAT PF02985.22 CCM06280.1 - 0.038 14.2 4.0 71 4.1 0.0 5.0 6 0 0 6 6 6 0 HEAT repeat NopRA1 PF16201.5 CCM06280.1 - 0.08 12.5 0.1 3.1 7.3 0.0 2.8 2 0 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 RasGEF_N_2 PF14663.6 CCM06280.1 - 0.11 12.9 0.1 3.8 7.9 0.0 2.9 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain V-ATPase_H_C PF11698.8 CCM06280.1 - 0.78 9.9 2.6 15 5.8 0.0 3.6 3 1 1 4 4 4 0 V-ATPase subunit H FAM75 PF14650.6 CCM06280.1 - 6.7 6.2 12.2 14 5.1 12.2 1.4 1 0 0 1 1 1 0 FAM75 family SF3b1 PF08920.10 CCM06281.1 - 2e-24 86.4 1.5 2e-24 86.4 1.5 2.8 3 0 0 3 3 3 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 CCM06281.1 - 2.9e-09 37.2 14.0 0.0044 17.4 0.1 7.9 5 2 4 9 9 9 3 HEAT repeats HEAT_EZ PF13513.6 CCM06281.1 - 5.2e-08 33.2 10.5 0.0078 16.7 0.0 7.6 9 1 1 10 10 9 2 HEAT-like repeat HEAT PF02985.22 CCM06281.1 - 7.9e-08 31.9 11.9 0.064 13.5 0.1 9.9 12 0 0 12 12 10 1 HEAT repeat Adaptin_N PF01602.20 CCM06281.1 - 4.1e-07 29.0 2.3 0.014 14.0 0.1 3.4 2 1 0 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 CCM06281.1 - 1.1e-06 29.1 1.2 0.79 10.4 0.0 5.4 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CCM06281.1 - 3e-06 27.4 8.4 0.37 10.8 0.0 6.6 8 0 0 8 8 8 1 non-SMC mitotic condensation complex subunit 1 NUC173 PF08161.12 CCM06281.1 - 3.3e-05 23.6 0.5 1.9 8.1 0.0 5.0 4 1 1 5 5 5 2 NUC173 domain CLASP_N PF12348.8 CCM06281.1 - 0.00021 20.9 1.8 0.32 10.5 0.0 3.8 3 1 0 3 3 3 2 CLASP N terminal UME PF08064.13 CCM06281.1 - 0.0003 20.7 0.6 0.36 10.8 0.0 4.6 5 2 1 6 6 6 1 UME (NUC010) domain MMS19_C PF12460.8 CCM06281.1 - 0.00093 18.4 0.0 4.2 6.4 0.0 4.2 3 1 0 4 4 4 1 RNAPII transcription regulator C-terminal DUF3110 PF11360.8 CCM06281.1 - 0.0065 16.6 0.1 0.02 15.1 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3110) Dopey_N PF04118.14 CCM06281.1 - 0.052 12.7 1.9 2.4 7.2 0.0 3.6 4 1 0 4 4 4 0 Dopey, N-terminal Pro_isomerase PF00160.21 CCM06282.1 - 9e-39 133.3 0.0 1.9e-38 132.2 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GTP_CH_N PF12471.8 CCM06283.1 - 1.1e-52 178.7 0.0 1.5e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 CCM06283.1 - 4.1e-15 55.8 0.0 5.9e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II Ribonuclease_3 PF00636.26 CCM06284.1 - 2e-39 134.4 0.0 1.9e-20 73.5 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 CCM06284.1 - 6.4e-24 83.9 0.0 1.6e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 CCM06284.1 - 1.8e-23 83.1 0.9 2.8e-10 40.4 0.1 4.3 3 1 0 3 3 3 2 Ribonuclease-III-like Helicase_C PF00271.31 CCM06284.1 - 4.9e-14 52.6 0.0 1.3e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM06284.1 - 7.5e-13 48.8 0.0 1.4e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CCM06284.1 - 2.3e-12 47.1 0.0 4.4e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CCM06284.1 - 0.071 13.4 0.0 0.3 11.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain Ion_trans PF00520.31 CCM06285.1 - 6.4e-15 55.0 16.1 2.4e-08 33.5 13.3 2.1 1 1 1 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 CCM06285.1 - 4.1e-13 49.1 1.0 4.1e-13 49.1 1.0 2.5 2 1 0 2 2 2 1 Ion channel Lig_chan PF00060.26 CCM06285.1 - 0.031 14.1 3.0 0.061 13.2 0.1 2.2 2 0 0 2 2 2 0 Ligand-gated ion channel Flavoprotein PF02441.19 CCM06287.1 - 5.1e-47 159.6 0.0 1.4e-46 158.1 0.0 1.6 1 1 0 1 1 1 1 Flavoprotein Homeodomain PF00046.29 CCM06288.1 - 0.00035 20.4 0.5 0.00056 19.7 0.5 1.3 1 0 0 1 1 1 1 Homeodomain HTH_29 PF13551.6 CCM06288.1 - 0.026 14.5 0.1 0.055 13.5 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.6 CCM06288.1 - 0.15 11.9 0.8 0.32 10.9 0.8 1.5 1 0 0 1 1 1 0 Homeodomain-like domain DUF2206 PF09971.9 CCM06289.1 - 0.16 10.7 4.3 0.34 9.6 4.3 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Mob1_phocein PF03637.17 CCM06291.1 - 1.9e-66 223.2 1.1 2.4e-66 222.9 1.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family SKN1 PF03935.15 CCM06292.1 - 4.5e-07 28.6 0.0 6.3e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) OPT PF03169.15 CCM06293.1 - 7.2e-94 315.6 46.0 8.5e-94 315.3 46.0 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Cu_amine_oxid PF01179.20 CCM06294.1 - 1.4e-123 412.9 0.6 1.9e-123 412.4 0.6 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 CCM06294.1 - 6.5e-11 41.8 0.0 1.8e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 CCM06294.1 - 0.00077 19.6 0.0 0.0015 18.7 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Synaptobrevin PF00957.21 CCM06295.1 - 2.7e-14 52.7 0.7 4e-14 52.2 0.7 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CCM06295.1 - 2.7e-12 46.5 0.0 5.2e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Peptidase_M50 PF02163.22 CCM06296.1 - 3.6e-10 39.6 5.3 9.8e-09 34.8 2.5 3.3 2 1 0 2 2 2 1 Peptidase family M50 CAAD PF14159.6 CCM06296.1 - 1.6 8.7 6.1 0.18 11.6 1.0 2.2 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Pkinase PF00069.25 CCM06297.1 - 3e-08 33.3 0.0 5.5e-08 32.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06297.1 - 0.00091 18.6 0.0 0.0019 17.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCM06297.1 - 0.048 13.0 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM06297.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 CCM06297.1 - 0.071 12.4 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.25 CCM06298.1 - 0.013 14.9 0.0 0.014 14.7 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Nup84_Nup100 PF04121.13 CCM06298.1 - 0.044 11.9 0.0 0.058 11.5 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore protein 84 / 107 Pkinase_fungal PF17667.1 CCM06299.1 - 5.7e-19 68.2 0.0 8.9e-19 67.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Nrap_D4 PF17405.2 CCM06300.1 - 8.9e-63 211.5 0.0 1.7e-62 210.6 0.0 1.5 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 CCM06300.1 - 1.9e-46 158.0 0.0 5e-46 156.7 0.0 1.7 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D2 PF17403.2 CCM06300.1 - 1.7e-41 141.5 0.0 3.6e-41 140.4 0.0 1.6 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain Nrap_D5 PF17406.2 CCM06300.1 - 5e-39 133.7 0.0 4.3e-36 124.1 0.0 2.6 2 0 0 2 2 2 2 Nrap protein PAP/OAS1-like domain 5 Nrap_D6 PF17407.2 CCM06300.1 - 8.2e-37 126.4 0.0 2e-36 125.2 0.0 1.7 2 0 0 2 2 2 1 Nrap protein domain 6 Nrap PF03813.14 CCM06300.1 - 9.8e-35 119.8 0.0 1.6e-34 119.2 0.0 1.3 1 0 0 1 1 1 1 Nrap protein domain 1 DUF4939 PF16297.5 CCM06301.1 - 0.0032 17.3 0.0 0.0065 16.3 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) TPR_1 PF00515.28 CCM06303.1 - 1.6e-51 170.1 26.9 9e-08 31.6 0.0 11.0 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 CCM06303.1 - 2e-48 158.6 17.8 7.7e-06 25.6 0.5 10.8 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 CCM06303.1 - 1.8e-38 127.5 12.5 0.00049 20.1 1.6 10.8 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_16 PF13432.6 CCM06303.1 - 7.1e-29 100.2 9.7 1.2e-05 25.8 0.0 7.0 3 2 4 7 7 7 7 Tetratricopeptide repeat TPR_14 PF13428.6 CCM06303.1 - 7e-26 88.7 19.1 0.0079 16.9 0.1 10.4 3 2 8 11 11 11 7 Tetratricopeptide repeat TPR_12 PF13424.6 CCM06303.1 - 1.6e-25 89.2 16.5 0.00016 21.9 0.4 7.5 3 3 4 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 CCM06303.1 - 6.5e-24 82.5 14.7 0.00083 19.6 0.3 10.1 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_6 PF13174.6 CCM06303.1 - 3.2e-23 80.8 11.0 0.08 13.6 0.0 9.6 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_11 PF13414.6 CCM06303.1 - 3.6e-23 81.0 29.7 3.6e-06 26.5 0.4 10.0 6 3 3 9 9 9 8 TPR repeat TPR_19 PF14559.6 CCM06303.1 - 2.9e-22 79.0 16.0 0.00022 21.6 0.3 7.2 5 1 2 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 CCM06303.1 - 4.5e-22 76.4 8.9 0.052 13.6 0.0 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_9 PF13371.6 CCM06303.1 - 9.6e-16 57.7 13.9 0.0088 16.2 0.3 6.7 3 3 4 7 7 7 6 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM06303.1 - 3.9e-10 39.8 8.9 4.2e-06 26.9 1.1 3.8 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CCM06303.1 - 9.4e-09 34.9 10.2 0.053 12.7 1.2 5.8 1 1 6 7 7 7 4 Tetratricopeptide repeat TPR_MalT PF17874.1 CCM06303.1 - 9.7e-06 25.2 1.6 0.00014 21.4 0.2 2.8 2 1 0 2 2 2 1 MalT-like TPR region TPR_21 PF09976.9 CCM06303.1 - 0.00011 22.0 5.9 0.023 14.4 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat-like domain SNAP PF14938.6 CCM06303.1 - 0.00035 20.1 12.5 0.056 12.9 0.6 4.4 2 2 1 4 4 4 2 Soluble NSF attachment protein, SNAP TPR_20 PF14561.6 CCM06303.1 - 0.00075 19.8 1.9 0.023 15.0 0.1 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF2225 PF09986.9 CCM06303.1 - 0.0057 16.4 2.5 1.6 8.4 0.1 3.3 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) DUF4919 PF16266.5 CCM06303.1 - 0.013 15.5 0.4 2.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) RPN7 PF10602.9 CCM06303.1 - 0.044 13.5 2.1 13 5.4 0.1 4.3 4 2 1 5 5 5 0 26S proteasome subunit RPN7 ChAPs PF09295.10 CCM06303.1 - 0.045 12.8 0.7 9.9 5.0 0.1 2.5 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.17 CCM06303.1 - 0.12 12.8 8.0 2.7 8.4 0.2 4.1 3 1 1 4 4 4 0 Bacterial transcriptional activator domain TPR_3 PF07720.12 CCM06303.1 - 0.32 11.1 23.8 2.7 8.1 1.2 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 CCM06303.1 - 0.35 10.8 19.6 1.2 9.1 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CCM06303.1 - 0.38 10.8 2.3 13 5.9 0.0 4.0 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat SLATT_fungal PF18142.1 CCM06304.1 - 6.6e-38 129.4 1.0 1.4e-37 128.3 0.1 1.8 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain CoatB PF10389.9 CCM06304.1 - 0.11 12.4 3.1 0.36 10.7 2.8 2.0 2 0 0 2 2 2 0 Bacteriophage coat protein B DUF4231 PF14015.6 CCM06304.1 - 0.15 12.5 0.2 0.59 10.6 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) ECM11 PF15463.6 CCM06304.1 - 0.72 10.4 2.6 2.8 8.5 2.6 2.0 1 1 0 1 1 1 0 Extracellular mutant protein 11 Glyco_transf_20 PF00982.21 CCM06307.1 - 2e-144 481.8 0.0 2.9e-144 481.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CCM06307.1 - 7.1e-20 71.1 0.0 1.3e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 CCM06307.1 - 0.047 13.4 0.0 0.16 11.6 0.0 1.8 2 0 0 2 2 2 0 Starch synthase catalytic domain Cellulase PF00150.18 CCM06308.1 - 2.5e-06 27.2 0.1 4.3e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF5129 PF17173.4 CCM06308.1 - 0.067 12.3 0.3 0.11 11.6 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) Glyco_hydro_12 PF01670.16 CCM06310.1 - 2.5e-22 79.9 9.1 9.8e-22 78.0 9.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 DUF2990 PF11693.8 CCM06310.1 - 0.062 13.5 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2990) MFS_1 PF07690.16 CCM06311.1 - 1.9e-37 129.0 73.8 7.3e-30 104.1 16.6 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily TRI12 PF06609.13 CCM06311.1 - 1.6e-06 26.8 3.2 1.6e-06 26.8 3.2 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) AAA_29 PF13555.6 CCM06314.1 - 0.016 14.9 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 CCM06314.1 - 0.035 13.2 0.3 0.059 12.4 0.1 1.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 CCM06314.1 - 0.036 13.7 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 CCM06314.1 - 0.12 11.6 0.2 0.76 9.0 0.0 1.9 2 0 0 2 2 2 0 ATPase MipZ DAP3 PF10236.9 CCM06314.1 - 0.23 10.6 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 adh_short PF00106.25 CCM06315.1 - 5.4e-26 91.3 0.0 2.3e-24 85.9 0.0 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06315.1 - 1.9e-18 66.9 0.1 4.6e-17 62.4 0.1 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06315.1 - 7.6e-06 26.0 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM06315.1 - 0.00018 21.0 0.0 0.00041 19.9 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CCM06315.1 - 0.1 12.5 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 CCM06317.1 - 7.6e-26 90.8 0.7 2.3e-19 69.6 0.1 3.0 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06317.1 - 3.5e-13 49.7 1.0 2.8e-09 36.9 1.0 3.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06317.1 - 2.8e-07 30.6 0.1 4.8e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM06317.1 - 3.1e-05 23.6 0.6 0.00051 19.6 0.6 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CCM06317.1 - 0.013 15.5 0.1 0.041 13.9 0.1 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 CCM06317.1 - 0.052 12.7 0.1 0.085 12.0 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_7 PF13241.6 CCM06317.1 - 0.12 12.8 0.1 0.29 11.6 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CCM06317.1 - 0.14 12.4 0.2 0.33 11.2 0.2 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HMG_box PF00505.19 CCM06318.1 - 5.9e-14 52.2 0.3 1.1e-13 51.3 0.3 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CCM06318.1 - 0.00088 19.8 0.0 0.0018 18.8 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain F-box-like PF12937.7 CCM06319.1 - 0.00034 20.4 0.7 0.0011 18.9 0.7 1.9 1 0 0 1 1 1 1 F-box-like F-box-like_2 PF13013.6 CCM06320.1 - 0.018 15.0 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 F-box-like domain F-box-like PF12937.7 CCM06320.1 - 0.048 13.6 0.0 0.19 11.7 0.0 2.0 2 0 0 2 2 2 0 F-box-like RPN7 PF10602.9 CCM06321.1 - 3.8e-39 134.2 1.3 6.2e-39 133.5 1.3 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CCM06321.1 - 4e-16 59.4 1.0 1.1e-15 58.0 0.2 2.2 2 1 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 CCM06321.1 - 0.016 15.2 0.1 0.037 14.0 0.1 1.5 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family Peptidase_M60 PF13402.6 CCM06321.1 - 0.067 12.7 0.0 0.29 10.6 0.0 2.0 2 0 0 2 2 2 0 Peptidase M60, enhancin and enhancin-like SbsC_C PF18058.1 CCM06321.1 - 3.9 7.7 6.7 1.3 9.2 0.2 2.7 2 0 0 2 2 2 0 SbsC C-terminal domain GST_N_3 PF13417.6 CCM06322.1 - 1.7e-11 44.4 0.1 7.6e-11 42.3 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CCM06322.1 - 1.1e-08 35.3 0.0 2.1e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM06322.1 - 8.9e-08 32.0 0.0 2.9e-07 30.4 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CCM06322.1 - 1.2e-05 25.5 0.0 2.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM06322.1 - 3.8e-05 23.8 0.0 0.00011 22.3 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCM06322.1 - 0.00013 22.1 0.0 0.0029 17.8 0.0 2.8 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CCM06322.1 - 0.066 13.8 0.0 0.2 12.2 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain SGS PF05002.15 CCM06323.1 - 2e-34 117.5 0.9 3e-34 117.0 0.9 1.3 1 0 0 1 1 1 1 SGS domain CS PF04969.16 CCM06323.1 - 3.9e-08 34.2 0.0 5.5e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 CS domain DUF2057 PF09829.9 CCM06323.1 - 0.13 12.4 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) DHFR_1 PF00186.19 CCM06324.1 - 2.3e-25 89.2 0.0 3.5e-25 88.6 0.0 1.4 1 1 0 1 1 1 1 Dihydrofolate reductase Metallophos PF00149.28 CCM06325.1 - 1e-18 68.6 0.0 3.1e-14 54.0 0.0 2.7 1 1 2 3 3 3 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCM06325.1 - 4.4e-15 55.9 0.0 7.4e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Ribosomal_S17_N PF16205.5 CCM06326.1 - 7.1e-32 109.6 0.7 1.3e-31 108.8 0.7 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CCM06326.1 - 1.2e-27 95.8 0.7 2e-27 95.0 0.4 1.6 2 0 0 2 2 2 1 Ribosomal protein S17 DUF4939 PF16297.5 CCM06327.1 - 0.00029 20.7 0.0 0.0004 20.2 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.17 CCM06327.1 - 0.058 13.7 0.0 0.092 13.0 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon gag protein RVT_1 PF00078.27 CCM06328.1 - 7e-26 91.1 0.5 1.2e-25 90.4 0.1 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) PSP1 PF04468.12 CCM06329.1 - 1.1e-29 102.5 2.8 1.8e-29 101.9 2.8 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Inhibitor_I66 PF16850.5 CCM06330.1 - 0.00024 21.0 0.1 0.0003 20.7 0.1 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I66 DUF4886 PF16227.5 CCM06330.1 - 0.082 12.1 0.6 0.1 11.8 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) RicinB_lectin_2 PF14200.6 CCM06330.1 - 0.12 13.1 0.1 0.69 10.7 0.0 1.9 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Dimerisation2 PF16864.5 CCM06332.1 - 9.3e-05 22.3 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 Dimerisation domain HTH_IclR PF09339.10 CCM06332.1 - 0.073 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain LRR_4 PF12799.7 CCM06333.1 - 0.0037 17.6 0.1 0.83 10.2 0.0 3.4 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) Cu_amine_oxid PF01179.20 CCM06334.1 - 1.3e-155 518.4 0.0 1.6e-155 518.1 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 CCM06334.1 - 1.7e-12 47.6 0.0 3.8e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 CCM06334.1 - 2.3e-06 27.8 0.0 4.9e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain p450 PF00067.22 CCM06335.1 - 4.1e-38 131.3 0.0 4.4e-38 131.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PLD_C PF12357.8 CCM06335.1 - 0.0099 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 Phospholipase D C terminal MFS_1 PF07690.16 CCM06336.1 - 1.6e-49 168.7 39.5 1.2e-45 156.0 28.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCM06336.1 - 2.2e-10 39.4 4.1 0.0031 15.9 0.3 3.2 2 1 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 CCM06336.1 - 1.5e-07 30.7 24.9 0.00044 19.2 9.8 3.0 2 1 0 2 2 2 2 MFS_1 like family Vac17 PF17321.2 CCM06337.1 - 0.085 12.3 8.6 0.12 11.8 8.6 1.2 1 0 0 1 1 1 0 Vacuole-related protein 17 Med9 PF07544.13 CCM06339.1 - 4.8e-10 39.4 1.6 5.9e-10 39.1 1.6 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Sigma70_r1_1 PF03979.14 CCM06339.1 - 0.012 15.7 0.7 0.018 15.1 0.6 1.6 1 1 0 1 1 1 0 Sigma-70 factor, region 1.1 Med21 PF11221.8 CCM06339.1 - 0.035 14.4 2.6 0.044 14.1 2.6 1.3 1 0 0 1 1 1 0 Subunit 21 of Mediator complex KELK PF15796.5 CCM06339.1 - 0.042 14.3 3.1 0.061 13.8 3.1 1.2 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF3500 PF12006.8 CCM06339.1 - 0.046 13.2 1.0 0.053 13.0 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) Arg_decarbox_C PF17944.1 CCM06339.1 - 0.092 13.3 4.3 3.4 8.3 0.1 2.7 1 1 2 3 3 3 0 Arginine decarboxylase C-terminal helical extension COesterase PF00135.28 CCM06340.1 - 1.2e-82 278.4 0.0 2.8e-82 277.3 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CCM06340.1 - 0.00017 21.1 0.0 0.00027 20.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CCM06340.1 - 0.00054 19.9 0.5 0.0035 17.2 0.5 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold PCI PF01399.27 CCM06341.1 - 7.5e-05 23.2 0.2 7.5e-05 23.2 0.2 2.5 3 0 0 3 3 3 1 PCI domain DUF4407 PF14362.6 CCM06341.1 - 0.0034 16.8 21.4 0.058 12.7 1.6 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) DUF3915 PF13054.6 CCM06341.1 - 0.95 9.5 10.3 2.1 8.3 10.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) V_ATPase_I PF01496.19 CCM06341.1 - 7.5 4.3 8.3 11 3.7 8.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DinB_2 PF12867.7 CCM06341.1 - 7.5 7.1 7.2 20 5.7 0.1 3.3 2 2 0 2 2 2 0 DinB superfamily Pkinase_fungal PF17667.1 CCM06342.1 - 3.6e-20 72.1 0.0 4.8e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06342.1 - 1.2e-11 44.5 0.0 1.8e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06342.1 - 8e-08 31.9 0.0 1.3e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM06342.1 - 0.0029 17.6 0.1 0.0057 16.6 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CCM06342.1 - 0.0031 16.9 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CCM06342.1 - 0.03 13.9 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 CCM06342.1 - 0.052 13.1 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Nop14 PF04147.12 CCM06344.1 - 0.026 12.8 2.8 0.027 12.7 2.8 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 CCM06344.1 - 0.12 11.7 5.9 0.17 11.2 5.9 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 CCM06344.1 - 0.3 9.4 2.8 0.28 9.4 2.8 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 CCM06344.1 - 0.34 11.3 13.8 0.63 10.5 13.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pox_Ag35 PF03286.14 CCM06344.1 - 1.6 8.5 5.0 2.3 8.0 5.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 CCM06344.1 - 2.3 7.8 5.2 3.7 7.2 5.2 1.3 1 0 0 1 1 1 0 FAM176 family DUF2457 PF10446.9 CCM06344.1 - 2.5 7.2 13.0 1.2 8.2 10.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Sporozoite_P67 PF05642.11 CCM06344.1 - 5.1 5.1 13.0 6.1 4.8 13.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Paf1 PF03985.13 CCM06344.1 - 8 5.3 9.5 10 5.0 9.5 1.1 1 0 0 1 1 1 0 Paf1 DNA_pol_phi PF04931.13 CCM06344.1 - 9.5 4.2 12.0 12 3.8 12.0 1.0 1 0 0 1 1 1 0 DNA polymerase phi F-box PF00646.33 CCM06345.1 - 0.0014 18.4 0.3 0.0014 18.4 0.3 2.9 3 0 0 3 3 3 1 F-box domain FOXP-CC PF16159.5 CCM06350.1 - 0.0017 19.0 11.7 0.011 16.4 0.3 3.3 2 1 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_12 PF18658.1 CCM06350.1 - 0.067 12.8 0.4 11 5.7 0.0 2.8 1 1 1 2 2 2 0 Zinc-finger C2H2-type zf-C2H2 PF00096.26 CCM06350.1 - 0.1 13.1 0.4 0.1 13.1 0.4 4.3 4 1 0 4 4 4 0 Zinc finger, C2H2 type SAP30_Sin3_bdg PF13867.6 CCM06352.1 - 1.8e-05 25.0 0.2 3.4e-05 24.1 0.2 1.4 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Arteri_nsp7a PF16749.5 CCM06353.1 - 0.2 11.8 0.4 0.35 11.1 0.4 1.3 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha Sel1 PF08238.12 CCM06354.1 - 8.1e-13 48.6 6.0 4.7e-05 23.9 0.5 3.5 3 0 0 3 3 3 3 Sel1 repeat TPR_2 PF07719.17 CCM06354.1 - 0.27 11.5 1.2 39 4.7 1.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PBP PF01161.20 CCM06355.1 - 2e-12 47.5 0.3 4.1e-12 46.6 0.3 1.5 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein YgaB PF14182.6 CCM06355.1 - 0.27 11.7 0.8 5.7 7.4 0.3 2.3 2 0 0 2 2 2 0 YgaB-like protein DNA_topoisoIV PF00521.20 CCM06356.1 - 1e-127 426.6 0.0 3.2e-127 425.0 0.0 1.9 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CCM06356.1 - 7e-48 162.1 0.2 2.6e-47 160.3 0.2 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CCM06356.1 - 1.8e-29 102.5 3.0 3.4e-29 101.5 3.0 1.5 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 CCM06356.1 - 1e-13 51.8 0.0 2.5e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CCM06356.1 - 1.2e-08 35.2 0.0 6.1e-08 32.8 0.0 2.3 1 0 0 1 1 1 1 Toprim domain Secretin_N PF03958.17 CCM06356.1 - 0.092 13.2 1.3 2.3 8.7 0.0 3.4 3 0 0 3 3 3 0 Bacterial type II/III secretion system short domain UPF0016 PF01169.19 CCM06357.1 - 2.2e-42 143.2 16.8 8.9e-22 77.2 4.6 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 OFeT_1 PF16955.5 CCM06357.1 - 1.6e-05 24.7 0.7 0.0061 16.3 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron uptake permease, iron-lead transporter PIN_2 PF10130.9 CCM06357.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 PIN domain TerC PF03741.16 CCM06357.1 - 1.2 8.8 11.6 0.33 10.6 1.4 2.5 2 1 0 2 2 2 0 Integral membrane protein TerC family Peptidase_M17 PF00883.21 CCM06358.1 - 3.6e-81 272.8 0.2 5.6e-81 272.2 0.2 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CCM06358.1 - 0.00018 21.4 0.3 0.00038 20.3 0.3 1.5 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain F-box PF00646.33 CCM06359.1 - 0.0024 17.7 0.0 0.008 16.0 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CCM06359.1 - 0.02 14.8 0.1 0.067 13.1 0.0 1.8 2 0 0 2 2 2 0 F-box-like FHA PF00498.26 CCM06360.1 - 6.8e-16 58.4 0.0 1.4e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CCM06360.1 - 0.00091 19.5 0.1 0.0035 17.6 0.0 2.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain TRAF_BIRC3_bd PF16673.5 CCM06360.1 - 0.031 14.1 7.6 0.057 13.2 0.2 4.4 4 1 1 5 5 5 0 TNF receptor-associated factor BIRC3 binding domain Lipoprotein_7 PF01540.16 CCM06360.1 - 0.033 13.5 0.1 0.047 13.0 0.1 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein LZ3wCH PF18517.1 CCM06360.1 - 0.046 13.8 1.6 0.11 12.7 1.6 1.6 1 0 0 1 1 1 0 Leucine zipper with capping helix domain NPV_P10 PF05531.12 CCM06360.1 - 5.8 7.5 10.0 38 4.9 0.0 3.8 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 CCM06360.1 - 7.3 6.7 16.4 0.75 9.8 2.5 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Cation_ATPase_C PF00689.21 CCM06361.1 - 0.017 14.8 1.2 0.017 14.8 1.2 1.8 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus BTB PF00651.31 CCM06362.1 - 3.1e-22 78.9 0.0 1.3e-10 41.5 0.0 2.7 2 0 0 2 2 2 2 BTB/POZ domain DUF1752 PF08550.10 CCM06363.1 - 8.8e-08 31.9 10.3 1.7e-07 30.9 10.3 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) BTB PF00651.31 CCM06364.1 - 2.8e-20 72.6 0.0 1.2e-12 48.1 0.0 2.6 2 0 0 2 2 2 2 BTB/POZ domain CAP_GLY PF01302.25 CCM06365.1 - 2e-19 69.4 0.9 3.3e-19 68.6 0.9 1.4 1 0 0 1 1 1 1 CAP-Gly domain CCDC144C PF14915.6 CCM06365.1 - 0.045 12.9 86.9 0.019 14.1 13.6 5.0 2 1 2 5 5 5 0 CCDC144C protein coiled-coil region zf-CCHC_4 PF14392.6 CCM06365.1 - 0.1 12.4 4.2 3.8 7.3 0.2 2.6 2 0 0 2 2 2 0 Zinc knuckle CLIP1_ZNF PF16641.5 CCM06365.1 - 0.82 9.6 17.7 0.041 13.8 2.5 2.8 3 0 0 3 3 3 0 CLIP1 zinc knuckle Spc7 PF08317.11 CCM06365.1 - 1.6 7.6 106.8 0.0068 15.3 18.4 5.8 1 1 6 7 7 7 0 Spc7 kinetochore protein Fez1 PF06818.15 CCM06365.1 - 6.1 7.2 97.3 0.041 14.3 15.1 6.2 1 1 4 6 6 6 0 Fez1 zf-CCHC PF00098.23 CCM06365.1 - 6.8 7.0 14.0 1.9 8.7 3.5 3.3 3 0 0 3 3 3 0 Zinc knuckle CLASP_N PF12348.8 CCM06366.1 - 2.5e-22 79.6 0.0 3.6e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 CLASP N terminal Tti2 PF10521.9 CCM06366.1 - 0.037 13.6 0.1 0.087 12.4 0.1 1.6 1 0 0 1 1 1 0 Tti2 family Tho1_MOS11_C PF18592.1 CCM06367.1 - 5.2e-06 26.2 6.4 0.091 12.6 0.7 3.3 2 1 1 3 3 3 3 Tho1/MOS11 C-terminal domain Rho_N PF07498.12 CCM06367.1 - 0.006 16.5 0.2 0.006 16.5 0.2 1.8 2 0 0 2 2 2 1 Rho termination factor, N-terminal domain HeH PF12949.7 CCM06367.1 - 0.027 14.2 0.9 0.052 13.3 0.9 1.4 1 0 0 1 1 1 0 HeH/LEM domain SAP PF02037.27 CCM06367.1 - 0.098 12.4 1.9 1.4 8.7 0.7 2.9 2 1 0 2 2 2 0 SAP domain CCT_2 PF09425.10 CCM06367.1 - 0.35 10.8 0.1 0.35 10.8 0.1 3.0 3 0 0 3 3 3 0 Divergent CCT motif CBFB_NFYA PF02045.15 CCM06368.1 - 1.5e-27 96.0 7.7 1.5e-27 96.0 7.7 1.9 2 0 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DUF1387 PF07139.11 CCM06368.1 - 6.3 6.4 7.1 11 5.6 7.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Ribosomal_S13 PF00416.22 CCM06370.1 - 4.4e-55 185.5 2.6 5.1e-55 185.3 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 CCM06370.1 - 0.015 14.1 0.0 0.016 14.0 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF2746 PF10874.8 CCM06370.1 - 0.022 15.2 0.0 0.04 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) HHH_6 PF14579.6 CCM06370.1 - 0.024 14.9 0.1 0.085 13.1 0.1 1.9 1 1 0 1 1 1 0 Helix-hairpin-helix motif Syntaxin-6_N PF09177.11 CCM06370.1 - 0.14 12.7 0.0 0.28 11.8 0.0 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal tRNA-synt_2c PF01411.19 CCM06371.1 - 1.2e-198 661.1 0.0 1.6e-198 660.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CCM06371.1 - 1.9e-16 59.9 1.5 1.8e-15 56.7 0.5 2.5 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CCM06371.1 - 2.4e-10 41.0 4.1 6.8e-10 39.5 4.1 1.9 1 0 0 1 1 1 1 DHHA1 domain DUF3328 PF11807.8 CCM06372.1 - 9.5e-59 198.8 0.3 1.2e-58 198.5 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CCM06373.1 - 1.6e-33 116.3 5.0 1.9e-33 116.1 5.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CCM06374.1 - 8.9e-07 28.9 0.0 1.1e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_C50 PF03568.17 CCM06375.1 - 1.2e-140 469.1 0.0 2.1e-140 468.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C50 TPR_12 PF13424.6 CCM06375.1 - 2.5e-07 30.9 3.0 0.01 16.1 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CCM06375.1 - 0.0018 17.7 1.1 0.0046 16.4 0.3 1.9 2 0 0 2 2 2 1 MalT-like TPR region CHAT PF12770.7 CCM06375.1 - 0.0026 17.2 0.0 0.07 12.5 0.0 2.4 1 1 0 1 1 1 1 CHAT domain TPR_2 PF07719.17 CCM06375.1 - 0.0047 16.9 2.7 6.7 7.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 CCM06375.1 - 0.078 12.9 1.4 2.5 8.1 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CCM06375.1 - 0.17 12.1 0.4 0.81 10.0 0.4 2.2 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 CCM06375.1 - 0.4 11.6 4.6 19 6.4 0.6 4.2 1 1 2 3 3 3 0 Tetratricopeptide repeat Ric8 PF10165.9 CCM06376.1 - 1.4e-127 426.6 0.0 2e-127 426.0 0.0 1.2 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Med10 PF09748.9 CCM06376.1 - 5.4e-13 49.0 0.0 1.3e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF5349 PF17298.2 CCM06376.1 - 0.39 10.4 8.0 0.63 9.7 8.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5349) RRM_1 PF00076.22 CCM06377.1 - 1.1e-43 146.9 0.0 2.7e-22 78.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CCM06377.1 - 1.5e-05 25.0 0.0 0.24 11.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 CCM06377.1 - 0.00038 20.1 0.0 0.0015 18.1 0.0 2.0 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 CCM06377.1 - 0.00058 19.7 0.0 0.028 14.3 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1866) Nup35_RRM_2 PF14605.6 CCM06377.1 - 0.0082 16.1 0.1 0.063 13.3 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CCM06377.1 - 0.013 15.3 0.0 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Occluded RNA-recognition motif GDI PF00996.18 CCM06378.1 - 2.2e-42 145.1 0.0 5.8e-41 140.4 0.0 2.1 1 1 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 CCM06378.1 - 0.00083 19.5 0.1 0.0018 18.5 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ING PF12998.7 CCM06380.1 - 2.9e-10 40.6 1.6 2.2e-08 34.6 1.6 2.4 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Nuf2 PF03800.14 CCM06381.1 - 1.5e-32 112.6 0.0 5.2e-32 110.9 0.0 1.9 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 CCM06381.1 - 2.7e-31 108.0 26.0 2.7e-31 108.0 26.0 3.8 2 2 0 3 3 3 1 Designed helical repeat protein 10 domain GAS PF13851.6 CCM06381.1 - 0.0043 16.4 46.9 0.02 14.3 5.8 3.3 2 1 1 3 3 3 3 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 CCM06381.1 - 0.24 11.9 52.5 4.9 7.7 16.9 3.7 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF3450 PF11932.8 CCM06381.1 - 1 8.6 45.8 0.069 12.4 6.7 3.9 1 1 4 5 5 5 0 Protein of unknown function (DUF3450) SLATT_4 PF18186.1 CCM06381.1 - 1.4 8.6 17.2 0.028 14.0 1.6 3.5 2 2 2 4 4 4 0 SMODS and SLOG-associating 2TM effector domain family 4 YabA PF06156.13 CCM06381.1 - 1.4 9.6 34.9 2.3 8.9 0.1 4.5 2 2 2 4 4 4 0 Initiation control protein YabA CENP-F_leu_zip PF10473.9 CCM06381.1 - 5.8 6.9 51.8 0.57 10.2 11.6 3.2 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 CCM06381.1 - 7.3 5.4 50.3 0.53 9.1 21.6 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein Filament PF00038.21 CCM06381.1 - 8.1 5.9 46.8 0.39 10.2 25.4 3.1 1 1 0 2 2 2 0 Intermediate filament protein Helicase_C PF00271.31 CCM06382.1 - 1.6e-18 67.1 0.0 3e-17 63.0 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCM06382.1 - 2.1e-17 63.5 0.0 7.5e-17 61.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase RQC PF09382.10 CCM06382.1 - 3.9e-13 49.2 0.0 8.4e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 CCM06382.1 - 2.1e-12 47.6 9.3 6.5e-12 46.0 9.3 1.9 1 0 0 1 1 1 1 RecQ zinc-binding HEM4 PF02602.15 CCM06382.1 - 0.15 11.4 0.0 3.9 6.7 0.0 2.4 2 0 0 2 2 2 0 Uroporphyrinogen-III synthase HemD FUSC PF04632.12 CCM06383.1 - 7.6e-10 38.0 3.8 7.6e-10 38.0 3.8 2.0 3 0 0 3 3 3 1 Fusaric acid resistance protein family ArAE_2 PF10334.9 CCM06383.1 - 5e-07 29.8 2.8 7.9e-07 29.1 0.6 2.4 2 1 0 2 2 2 1 Aromatic acid exporter family member 2 HlyD PF00529.20 CCM06383.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.6 1 1 0 1 1 1 0 HlyD membrane-fusion protein of T1SS DUF2867 PF11066.8 CCM06383.1 - 0.092 13.1 0.2 0.22 11.8 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2867) ALMT PF11744.8 CCM06383.1 - 2.3 7.0 6.5 0.13 11.1 0.3 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter ArAE_1 PF06081.11 CCM06383.1 - 2.5 8.3 12.0 0.44 10.7 0.8 3.0 2 1 0 2 2 2 0 Aromatic acid exporter family member 1 DEAD PF00270.29 CCM06384.1 - 3.2e-45 154.0 0.0 9.4e-45 152.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CCM06384.1 - 7.1e-27 94.0 0.0 4.1e-26 91.5 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CCM06384.1 - 2.5e-06 27.6 0.0 6.1e-05 23.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SAM_DrpA PF18255.1 CCM06384.1 - 0.17 12.2 0.0 0.49 10.7 0.0 1.8 2 0 0 2 2 2 0 DNA processing protein A sterile alpha motif domain CMS1 PF14617.6 CCM06384.1 - 0.22 10.8 9.1 0.57 9.5 0.0 2.5 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit PTPRCAP PF15713.5 CCM06384.1 - 0.83 9.9 12.6 1.5 9.1 12.6 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 CCM06384.1 - 7.2 6.3 10.3 12 5.6 10.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GalP_UDP_transf PF01087.22 CCM06385.1 - 3.1e-63 213.5 0.0 1.3e-62 211.5 0.0 1.8 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 CCM06385.1 - 5.4e-49 166.1 0.0 1.1e-48 165.2 0.0 1.5 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 CCM06385.1 - 0.023 15.4 2.5 0.13 13.0 0.9 2.8 3 1 0 3 3 3 0 HIT domain DUF4921 PF16268.5 CCM06385.1 - 0.11 11.3 0.0 11 4.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4921) SLT PF01464.20 CCM06386.1 - 1.9e-11 43.7 0.0 3.6e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Transglycosylase SLT domain DAG1 PF05454.11 CCM06386.1 - 0.032 13.6 0.0 0.088 12.2 0.0 1.7 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM154 PF15102.6 CCM06386.1 - 0.042 13.8 0.2 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family DUF588 PF04535.12 CCM06386.1 - 0.049 13.4 5.6 0.37 10.6 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF588) MFS_1 PF07690.16 CCM06389.1 - 3.9e-42 144.5 37.2 3.9e-42 144.5 37.2 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM06389.1 - 3.8e-08 32.2 4.9 5.6e-06 25.1 1.6 2.3 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CCM06389.1 - 4.6e-07 29.1 27.5 1.6e-06 27.3 27.4 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter T2SSM PF04612.12 CCM06389.1 - 0.054 13.6 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Redoxin PF08534.10 CCM06390.1 - 1.8e-36 125.0 0.0 2.1e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CCM06390.1 - 6.3e-12 45.5 0.0 7.6e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family CTU2 PF10288.9 CCM06392.1 - 4.5e-15 55.9 0.4 4.5e-15 55.9 0.4 2.2 2 1 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 Aminotran_5 PF00266.19 CCM06393.1 - 3.2e-12 46.1 0.0 2.1e-05 23.7 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Aminotran_1_2 PF00155.21 CCM06393.1 - 9.3e-06 25.0 0.0 5.9e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CCM06393.1 - 0.0015 17.9 0.0 0.31 10.3 0.0 2.2 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3017 PF11222.8 CCM06393.1 - 0.24 11.6 0.0 0.48 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3017) Meckelin PF09773.9 CCM06395.1 - 0.11 10.5 3.0 0.19 9.8 3.0 1.3 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) Sugar_tr PF00083.24 CCM06396.1 - 1.8e-111 373.2 20.7 2e-111 373.0 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM06396.1 - 3.7e-20 72.2 37.5 4e-19 68.7 29.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Mac_assoc PF16628.5 CCM06397.1 - 0.036 14.3 0.3 7.9 6.6 0.0 2.4 1 1 1 2 2 2 0 Unstructured region on maltose acetyltransferase Flavodoxin_5 PF12724.7 CCM06397.1 - 0.2 11.9 0.1 27 5.0 0.0 2.6 3 0 0 3 3 3 0 Flavodoxin domain NUFIP1 PF10453.9 CCM06397.1 - 0.27 11.1 2.1 24 4.9 0.0 3.0 3 0 0 3 3 3 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Importin_rep_6 PF18829.1 CCM06397.1 - 2.6 8.2 0.0 2.6 8.2 0.0 2.8 2 1 1 3 3 3 0 Importin repeat 6 DUF3328 PF11807.8 CCM06398.1 - 1.5e-50 172.0 0.2 1.8e-50 171.8 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3216 PF11505.8 CCM06399.1 - 0.14 12.3 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) DUF3817 PF12823.7 CCM06400.1 - 0.2 12.5 3.4 0.19 12.6 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3817) Amnionless PF14828.6 CCM06400.1 - 0.33 9.7 0.1 0.5 9.1 0.1 1.3 1 0 0 1 1 1 0 Amnionless DUF3671 PF12420.8 CCM06400.1 - 0.38 10.8 1.0 11 6.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function F-box-like PF12937.7 CCM06401.1 - 0.025 14.5 1.2 0.025 14.5 1.2 1.9 2 0 0 2 2 2 0 F-box-like F-box PF00646.33 CCM06401.1 - 0.095 12.6 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 F-box domain Ammonium_transp PF00909.21 CCM06402.1 - 2.3e-105 352.5 24.3 2.9e-105 352.3 24.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family LIP PF03583.14 CCM06402.1 - 0.0015 17.9 1.5 0.0037 16.6 1.7 1.5 2 0 0 2 2 2 1 Secretory lipase Innate_immun PF12782.7 CCM06403.1 - 0.06 12.9 5.6 0.068 12.7 5.6 1.0 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family Bep_C_terminal PF17841.1 CCM06406.1 - 0.19 12.0 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 BID domain of Bartonella effector protein (Bep) WD40 PF00400.32 CCM06407.1 - 1.3e-96 313.9 49.6 1.8e-09 38.0 0.5 10.1 10 0 0 10 10 10 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06407.1 - 2.9e-15 56.3 21.7 0.21 11.9 0.1 9.7 1 1 9 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCM06407.1 - 4.2e-12 46.2 3.8 4.6 7.9 0.0 9.4 10 0 0 10 10 10 1 PQQ-like domain PD40 PF07676.12 CCM06407.1 - 1e-08 34.9 0.1 28 4.8 0.0 8.8 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CCM06407.1 - 2.4e-07 30.0 7.7 5.1 6.0 0.0 7.9 1 1 9 10 10 10 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 CCM06407.1 - 3.7e-06 26.0 25.6 0.61 8.8 0.1 8.5 1 1 8 9 9 9 4 Nup133 N terminal like WD40_like PF17005.5 CCM06407.1 - 5.3e-06 26.0 0.0 5.1 6.3 0.0 6.1 4 2 1 5 5 5 2 WD40-like domain CHAP PF05257.16 CCM06407.1 - 2.6e-05 24.7 23.2 3.7 8.2 0.1 8.2 1 1 7 9 9 9 1 CHAP domain DUF4072 PF13284.6 CCM06407.1 - 0.00024 21.5 15.9 19 5.8 0.1 8.5 9 1 1 10 10 9 0 Domain of unknown function (DUF4072) Frtz PF11768.8 CCM06407.1 - 0.00043 18.7 0.1 22 3.2 0.0 5.4 3 3 1 5 5 5 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF727 PF05303.12 CCM06407.1 - 0.00077 19.5 5.6 7.4 6.7 0.0 7.5 4 3 5 10 10 10 1 Protein of unknown function (DUF727) AsnC_trans_reg PF01037.21 CCM06407.1 - 0.0011 18.9 6.6 7.7 6.6 0.0 6.8 9 0 0 9 9 8 1 Lrp/AsnC ligand binding domain AHJR-like PF18743.1 CCM06407.1 - 0.0017 17.9 0.2 37 3.9 0.0 4.6 4 1 1 5 5 5 0 REase_AHJR-like FeThRed_A PF02941.15 CCM06407.1 - 0.0097 16.0 8.2 58 3.9 0.0 6.8 5 4 4 9 9 9 0 Ferredoxin thioredoxin reductase variable alpha chain Peptidase_S78_2 PF14550.6 CCM06407.1 - 0.83 9.8 5.4 9.9 6.3 0.2 3.1 1 1 0 2 2 2 0 Putative phage serine protease XkdF Nup160 PF11715.8 CCM06407.1 - 5.8 5.4 26.0 15 4.1 0.1 8.2 7 2 3 10 10 10 0 Nucleoporin Nup120/160 AAA_16 PF13191.6 CCM06409.1 - 4e-06 27.3 1.3 1e-05 26.0 0.0 2.2 3 0 0 3 3 3 1 AAA ATPase domain PARP PF00644.20 CCM06411.1 - 3.3e-05 23.6 0.0 0.13 11.8 0.1 2.1 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Glyco_transf_9 PF01075.17 CCM06411.1 - 0.027 13.8 0.0 0.4 9.9 0.0 2.0 1 1 0 1 1 1 0 Glycosyltransferase family 9 (heptosyltransferase) DUF1768 PF08719.11 CCM06412.1 - 4e-30 105.2 0.0 5.6e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) DUF1768 PF08719.11 CCM06414.1 - 5.3e-24 85.3 0.1 1.4e-23 83.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) CCDC71L PF15374.6 CCM06414.1 - 0.0082 15.5 4.5 0.015 14.6 4.5 1.4 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 71L UPF0154 PF03672.13 CCM06414.1 - 0.37 10.8 4.6 1.2 9.2 4.6 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) RPAP2_Rtr1 PF04181.13 CCM06415.1 - 0.047 14.0 7.4 7 7.1 0.1 3.2 3 0 0 3 3 3 0 Rtr1/RPAP2 family Saf_2TM PF18303.1 CCM06416.1 - 0.022 14.3 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF3426 PF11906.8 CCM06416.1 - 0.063 13.4 0.0 0.082 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3426) S1FA PF04689.13 CCM06416.1 - 0.24 11.6 0.8 0.46 10.7 0.8 1.4 1 0 0 1 1 1 0 DNA binding protein S1FA PARP PF00644.20 CCM06417.1 - 2.4e-13 50.1 2.0 1.2e-09 38.1 0.2 2.8 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Aminotran_1_2 PF00155.21 CCM06418.1 - 8.7e-25 87.6 0.0 1.1e-24 87.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CCM06418.1 - 1e-12 47.6 0.0 1.3e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase VirB3 PF05101.13 CCM06419.1 - 0.046 14.0 1.7 0.056 13.7 1.7 1.1 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein RVT_1 PF00078.27 CCM06420.1 - 0.0011 18.5 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SET PF00856.28 CCM06421.1 - 4.2e-13 50.0 0.0 1.1e-12 48.7 0.0 1.7 1 1 0 1 1 1 1 SET domain SAF PF08666.12 CCM06421.1 - 0.0021 18.6 0.0 0.016 15.8 0.1 2.2 2 0 0 2 2 2 1 SAF domain SAGA-Tad1 PF12767.7 CCM06421.1 - 0.19 11.5 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit C2 PF00168.30 CCM06422.1 - 2.5e-06 27.7 0.0 3.6e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 C2 domain Peroxidase_2 PF01328.17 CCM06423.1 - 3e-51 174.6 0.0 3.9e-51 174.2 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 polyprenyl_synt PF00348.17 CCM06424.1 - 1.4e-58 198.0 0.0 1.7e-58 197.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase zf_PR_Knuckle PF18445.1 CCM06424.1 - 0.19 11.6 0.1 0.43 10.4 0.1 1.5 1 0 0 1 1 1 0 PR zinc knuckle motif Cupin_1 PF00190.22 CCM06425.1 - 2.8e-41 140.6 0.0 1.4e-19 70.2 0.0 2.3 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCM06425.1 - 6.2e-26 89.9 0.2 5.1e-12 45.3 0.0 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCM06425.1 - 1e-05 25.1 0.0 0.00061 19.4 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCM06425.1 - 1.5e-05 24.9 0.2 3.9e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCM06425.1 - 0.0011 18.9 0.0 0.017 15.0 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase 3-HAO PF06052.12 CCM06425.1 - 0.057 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase ARD PF03079.14 CCM06425.1 - 0.063 13.5 0.1 0.69 10.1 0.0 2.1 2 0 0 2 2 2 0 ARD/ARD' family cNMP_binding PF00027.29 CCM06425.1 - 0.12 12.5 0.1 0.42 10.7 0.0 1.9 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain Pirin_C PF05726.13 CCM06425.1 - 0.15 12.5 0.0 4.3 7.8 0.0 2.6 3 0 0 3 3 3 0 Pirin C-terminal cupin domain Asp PF00026.23 CCM06426.1 - 1.1e-26 94.0 4.1 1.1e-26 94.0 4.1 2.7 2 1 0 2 2 2 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CCM06426.1 - 1e-05 26.0 0.3 4.1e-05 24.1 0.3 2.0 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CCM06426.1 - 0.0022 18.5 0.0 0.0066 17.0 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Trp_oprn_chp PF09534.10 CCM06426.1 - 0.0031 17.3 2.0 0.0057 16.5 2.0 1.4 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4064 PF13273.6 CCM06426.1 - 0.064 13.5 0.0 0.27 11.5 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) TAXi_N PF14543.6 CCM06426.1 - 0.13 12.5 1.7 5.3 7.2 0.0 2.9 2 1 1 3 3 3 0 Xylanase inhibitor N-terminal Adaptin_N PF01602.20 CCM06428.1 - 2.8e-113 379.2 0.1 7.1e-113 377.9 0.1 1.5 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CCM06428.1 - 1.1e-13 51.5 1.3 2.6e-11 43.8 0.0 3.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCM06428.1 - 1.4e-08 35.0 8.4 0.00091 19.6 0.1 4.8 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.22 CCM06428.1 - 3e-05 23.9 5.9 1.3 9.5 0.1 5.5 5 0 0 5 5 5 2 HEAT repeat Cohesin_HEAT PF12765.7 CCM06428.1 - 0.0014 18.9 0.3 0.5 10.7 0.0 3.0 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.6 CCM06428.1 - 0.013 16.0 2.2 7.9 7.1 0.0 4.5 4 0 0 4 4 4 0 HEAT-like repeat MOR2-PAG1_C PF14225.6 CCM06428.1 - 0.023 14.6 0.7 7.5 6.3 0.1 2.6 2 0 0 2 2 2 0 Cell morphogenesis C-terminal SDA1 PF05285.12 CCM06428.1 - 0.049 13.1 9.7 0.078 12.4 9.7 1.3 1 0 0 1 1 1 0 SDA1 p450 PF00067.22 CCM06429.1 - 3.7e-46 157.8 0.0 2.1e-42 145.4 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 T3SS_HrpK1 PF16937.5 CCM06429.1 - 0.0042 16.8 0.1 0.066 12.9 0.0 2.1 2 0 0 2 2 2 1 Type III secretion system translocator protein, HrpF ICMT PF04140.14 CCM06430.1 - 8e-14 51.8 7.6 1.2e-13 51.3 2.2 2.9 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM06430.1 - 1.5e-09 38.2 3.9 1.5e-09 38.2 3.9 2.2 2 1 0 2 2 2 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 CCM06430.1 - 0.00015 20.6 0.8 0.00021 20.2 0.8 1.3 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Sina PF03145.16 CCM06431.1 - 0.24 11.3 0.2 9.7 6.1 0.0 2.1 2 0 0 2 2 2 0 Seven in absentia protein family Sina PF03145.16 CCM06432.1 - 0.00011 22.2 5.1 0.0033 17.4 3.0 2.3 2 0 0 2 2 2 2 Seven in absentia protein family FOXP-CC PF16159.5 CCM06432.1 - 0.066 13.9 3.9 0.14 12.8 0.7 2.7 1 1 2 3 3 3 0 FOXP coiled-coil domain Rx_N PF18052.1 CCM06432.1 - 0.11 12.7 0.2 0.26 11.6 0.2 1.5 1 0 0 1 1 1 0 Rx N-terminal domain zf-Di19 PF05605.12 CCM06432.1 - 0.86 9.9 7.7 16 5.8 1.4 3.1 2 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding NAM-associated PF14303.6 CCM06432.1 - 7.7 7.2 10.3 0.6 10.8 4.5 2.0 2 1 0 3 3 3 0 No apical meristem-associated C-terminal domain Aconitase PF00330.20 CCM06433.1 - 1.4e-107 360.6 0.0 1.3e-106 357.4 0.0 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CCM06433.1 - 1.4e-19 70.8 0.0 2.9e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 CCM06433.1 - 0.0042 15.9 0.0 0.0064 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF521) Aconitase_2_N PF06434.13 CCM06433.1 - 0.079 12.6 0.0 0.4 10.3 0.0 2.0 2 0 0 2 2 2 0 Aconitate hydratase 2 N-terminus MIB_HERC2 PF06701.13 CCM06433.1 - 0.1 12.9 0.1 0.57 10.5 1.0 1.8 2 0 0 2 2 2 0 Mib_herc2 MCM PF00493.23 CCM06433.1 - 0.12 11.5 0.1 0.35 9.9 0.1 1.7 2 0 0 2 2 2 0 MCM P-loop domain TauD PF02668.16 CCM06434.1 - 9e-39 133.9 0.0 1.2e-38 133.5 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 CCM06434.1 - 0.0015 17.7 0.1 0.0076 15.4 0.0 1.8 2 0 0 2 2 2 1 CsiD DUF2678 PF10856.8 CCM06435.1 - 4.5 7.2 7.5 15 5.6 0.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2678) Methyltransf_2 PF00891.18 CCM06436.1 - 1.3e-25 89.9 0.0 5.3e-25 87.9 0.0 1.8 1 1 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CCM06436.1 - 0.005 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_25 PF13649.6 CCM06436.1 - 0.011 16.4 0.0 0.025 15.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain HTH_IclR PF09339.10 CCM06436.1 - 0.039 13.8 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain MTS PF05175.14 CCM06436.1 - 0.08 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 CCM06436.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FMO-like PF00743.19 CCM06437.1 - 1.1e-20 73.5 0.2 2.9e-19 68.9 0.2 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCM06437.1 - 1.6e-15 57.2 0.0 5.4e-14 52.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM06437.1 - 8.8e-12 44.9 0.1 1.7e-08 34.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM06437.1 - 4.3e-09 36.0 0.0 3.5e-08 33.0 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CCM06437.1 - 0.00044 20.8 0.0 0.086 13.4 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase COesterase PF00135.28 CCM06438.1 - 1.8e-63 215.2 0.9 1e-44 153.3 0.3 2.5 1 1 1 2 2 2 2 Carboxylesterase family p450 PF00067.22 CCM06438.1 - 1.2e-10 40.8 0.0 1.6e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_3 PF07859.13 CCM06438.1 - 0.0008 19.3 0.2 0.0028 17.5 0.0 1.9 3 0 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CCM06438.1 - 0.0038 16.7 0.0 0.0069 15.9 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_GDSL_2 PF13472.6 CCM06439.1 - 1.4e-07 32.1 0.5 1.8e-07 31.7 0.5 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CCM06439.1 - 3.3e-07 30.5 0.1 4e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Adap_comp_sub PF00928.21 CCM06440.1 - 4.1e-84 282.1 0.2 5.2e-84 281.7 0.2 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CCM06440.1 - 7.1e-05 22.8 0.5 0.0002 21.3 0.5 1.8 1 1 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 CCM06440.1 - 0.027 13.9 0.6 0.051 13.0 0.6 1.4 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain ABM PF03992.16 CCM06440.1 - 0.028 14.5 0.1 0.097 12.8 0.1 1.8 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase DUF5618 PF18498.1 CCM06440.1 - 0.043 14.0 0.3 0.13 12.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5618) CENP-C_C PF11699.8 CCM06441.1 - 1.9e-28 98.5 1.5 3.4e-28 97.7 1.5 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 CCM06441.1 - 5.6e-05 22.8 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CCM06441.1 - 0.004 17.1 0.0 0.0084 16.0 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 CCM06441.1 - 0.0045 16.6 0.1 0.009 15.6 0.1 1.4 1 0 0 1 1 1 1 Cupin PA14 PF07691.12 CCM06441.1 - 0.042 13.7 0.0 0.099 12.4 0.0 1.6 1 0 0 1 1 1 0 PA14 domain Arteri_nucleo PF01481.16 CCM06441.1 - 0.057 13.7 0.6 2 8.7 0.1 2.9 2 0 0 2 2 2 0 Arterivirus nucleocapsid protein PAP_assoc PF03828.19 CCM06442.1 - 2.1e-17 63.1 0.1 4.8e-17 61.9 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CCM06442.1 - 2.4e-07 30.9 0.0 5.2e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain F-box PF00646.33 CCM06443.1 - 0.00023 21.0 1.1 0.0019 18.0 0.0 2.8 3 1 0 3 3 3 1 F-box domain F-box-like PF12937.7 CCM06443.1 - 0.0016 18.3 0.1 0.0047 16.8 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 CCM06443.1 - 0.017 14.7 0.1 0.041 13.5 0.1 1.7 1 1 0 1 1 1 0 F-box Pkinase_fungal PF17667.1 CCM06445.1 - 1.9e-11 43.4 0.3 2.7e-11 42.9 0.3 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06445.1 - 2.8e-09 36.7 0.0 3.7e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06445.1 - 1.2e-06 28.0 0.0 1.8e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CCM06445.1 - 0.09 12.1 0.0 0.26 10.6 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2457 PF10446.9 CCM06447.1 - 0.41 9.7 6.6 0.47 9.5 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PLU-1 PF08429.11 CCM06448.1 - 9e-50 169.7 4.4 9e-50 169.7 4.4 2.1 2 1 0 2 2 2 1 PLU-1-like protein JmjC PF02373.22 CCM06448.1 - 5.8e-42 142.7 0.5 5.8e-42 142.7 0.5 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.21 CCM06448.1 - 4.4e-18 65.7 0.0 1.4e-17 64.2 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.16 CCM06448.1 - 1.5e-16 60.5 10.7 1.5e-16 60.5 10.7 2.3 2 0 0 2 2 2 1 C5HC2 zinc finger JmjN PF02375.17 CCM06448.1 - 1.6e-16 59.9 0.2 4e-16 58.7 0.2 1.7 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 CCM06448.1 - 2.1e-16 59.6 41.0 4.4e-11 42.5 8.3 4.7 4 0 0 4 4 4 2 PHD-finger NST1 PF13945.6 CCM06449.1 - 2.3e-53 181.2 3.7 2.3e-53 181.2 3.7 4.7 3 1 2 5 5 5 1 Salt tolerance down-regulator PhoLip_ATPase_C PF16212.5 CCM06450.1 - 9.1e-53 179.6 25.9 9.1e-53 179.6 25.9 2.5 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CCM06450.1 - 2.9e-16 58.9 4.2 7e-16 57.7 4.2 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CCM06450.1 - 3e-16 60.4 0.3 1.9e-13 51.2 0.3 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CCM06450.1 - 3.1e-13 49.7 0.0 3.1e-13 49.7 0.0 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 CCM06450.1 - 3.8e-09 36.5 0.0 7.3e-08 32.4 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CCM06450.1 - 0.00016 21.5 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase FMO-like PF00743.19 CCM06451.1 - 6.9e-25 87.5 0.0 1.2e-24 86.6 0.0 1.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CCM06451.1 - 1.9e-18 66.8 0.0 3.2e-16 59.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CCM06451.1 - 8e-16 58.1 0.1 1.7e-11 43.9 0.0 2.9 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM06451.1 - 2.1e-11 43.5 0.0 1.9e-08 33.9 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.20 CCM06451.1 - 6.7e-05 23.0 0.0 0.0078 16.3 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 CCM06451.1 - 0.00047 20.4 0.0 0.035 14.4 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_9 PF13454.6 CCM06451.1 - 0.00091 19.2 0.5 0.99 9.4 0.0 2.8 3 0 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox PF00070.27 CCM06451.1 - 0.0028 18.2 0.0 4.2 8.0 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM06451.1 - 0.013 15.7 0.0 0.1 12.8 0.0 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CCM06451.1 - 0.04 13.5 0.5 1.1 8.7 0.5 2.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CCM06451.1 - 0.048 13.5 0.0 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SnoaL_2 PF12680.7 CCM06451.1 - 0.086 13.5 1.1 11 6.8 0.0 2.8 3 0 0 3 3 2 0 SnoaL-like domain AlaDh_PNT_C PF01262.21 CCM06451.1 - 0.088 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCM06451.1 - 0.1 11.9 0.1 0.67 9.3 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.14 CCM06451.1 - 0.15 10.7 0.0 0.49 9.1 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein Lsm_interact PF05391.11 CCM06453.1 - 0.095 12.2 1.5 0.18 11.3 1.5 1.4 1 0 0 1 1 1 0 Lsm interaction motif F-box-like PF12937.7 CCM06454.1 - 0.01 15.7 0.3 0.023 14.6 0.3 1.5 1 0 0 1 1 1 0 F-box-like CD52 PF15116.6 CCM06454.1 - 0.033 14.2 0.1 2.8 8.0 0.0 2.3 2 0 0 2 2 2 0 CAMPATH-1 antigen UPF0158 PF03682.13 CCM06454.1 - 0.053 13.5 0.0 0.084 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0158) p450 PF00067.22 CCM06458.1 - 2.3e-21 76.1 0.0 2.7e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RVT_1 PF00078.27 CCM06459.1 - 2.9e-07 30.2 0.6 0.00022 20.8 0.1 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) F-box-like PF12937.7 CCM06460.1 - 9.8e-12 44.6 6.8 1.7e-11 43.8 0.6 3.6 3 0 0 3 3 3 1 F-box-like F-box-like_2 PF13013.6 CCM06460.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 F-box-like domain F-box PF00646.33 CCM06460.1 - 6.8 6.7 12.6 2 8.4 4.0 3.9 3 1 0 3 3 3 0 F-box domain TPR_12 PF13424.6 CCM06462.1 - 0.013 15.8 0.0 0.25 11.6 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat BTB PF00651.31 CCM06462.1 - 0.018 15.3 0.0 0.048 13.9 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain Laminin_II PF06009.12 CCM06462.1 - 0.041 13.9 3.4 0.14 12.2 0.2 2.7 3 0 0 3 3 3 0 Laminin Domain II P-II PF00543.22 CCM06462.1 - 0.16 12.6 0.0 0.46 11.1 0.0 1.8 1 0 0 1 1 1 0 Nitrogen regulatory protein P-II Ndc1_Nup PF09531.10 CCM06463.1 - 0.06 12.0 2.2 0.073 11.7 2.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2407_C PF13373.6 CCM06464.1 - 0.73 10.0 3.0 0.96 9.6 0.0 2.2 2 1 0 2 2 2 0 DUF2407 C-terminal domain DUF973 PF06157.11 CCM06464.1 - 2.7 6.9 4.4 3.8 6.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF973) UBZ_FAAP20 PF15750.5 CCM06466.1 - 0.029 14.3 0.4 0.084 12.8 0.2 1.9 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger RTA1 PF04479.13 CCM06469.1 - 1.9e-54 184.4 8.5 2.9e-52 177.3 8.5 2.3 1 1 0 1 1 1 1 RTA1 like protein MFS_1 PF07690.16 CCM06470.1 - 3.8e-45 154.4 45.7 1.3e-44 152.5 44.1 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM06470.1 - 2.8e-15 55.8 12.9 4.4e-15 55.1 12.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pkinase_fungal PF17667.1 CCM06471.1 - 1e-46 159.5 0.0 2.3e-28 99.1 0.3 3.2 1 1 1 2 2 2 2 Fungal protein kinase APH PF01636.23 CCM06471.1 - 0.006 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM06472.1 - 1.2e-46 159.3 0.0 1.5e-27 96.4 0.1 3.0 1 1 1 2 2 2 2 Fungal protein kinase Pkinase PF00069.25 CCM06472.1 - 0.034 13.5 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain APH PF01636.23 CCM06472.1 - 0.043 13.7 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCM06473.1 - 1.6e-14 53.6 0.2 1.2e-07 30.9 0.0 3.0 1 1 1 2 2 2 2 Fungal protein kinase Herp-Cyclin PF09241.10 CCM06478.1 - 0.14 12.8 0.0 0.34 11.6 0.0 1.6 1 0 0 1 1 1 0 Herpesviridae viral cyclin Pkinase PF00069.25 CCM06481.1 - 7.5e-62 209.1 0.0 2.4e-61 207.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06481.1 - 4.4e-29 101.6 0.0 5.8e-20 71.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CCM06481.1 - 8.1e-05 22.1 0.8 0.019 14.3 0.0 2.9 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.14 CCM06481.1 - 0.0041 16.5 0.0 0.01 15.2 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM06481.1 - 0.005 16.8 0.1 0.041 13.8 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CCM06481.1 - 0.0053 15.7 0.0 0.026 13.4 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 CCM06481.1 - 0.04 13.5 0.0 0.096 12.3 0.0 1.6 1 0 0 1 1 1 0 RIO1 family MFS_1 PF07690.16 CCM06482.1 - 7.9e-12 44.8 35.5 1.6e-11 43.8 35.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CCM06482.1 - 7.7e-11 41.9 7.0 2.5e-10 40.3 7.0 1.8 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 TB2_DP1_HVA22 PF03134.19 CCM06483.1 - 1.3e-25 89.1 4.9 2.6e-25 88.1 4.9 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family TFIIS_C PF01096.18 CCM06483.1 - 1.9e-10 40.4 0.2 1.9e-10 40.4 0.2 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CCM06483.1 - 2e-07 30.8 6.3 8.9e-07 28.7 3.5 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit DZR PF12773.7 CCM06483.1 - 0.00084 19.3 3.4 0.015 15.3 0.9 2.2 2 0 0 2 2 2 1 Double zinc ribbon Mu-like_Com PF10122.9 CCM06483.1 - 0.048 13.1 4.5 0.5 9.9 0.0 2.8 2 1 0 2 2 2 0 Mu-like prophage protein Com IBR PF01485.21 CCM06483.1 - 0.049 13.9 1.5 0.44 10.8 0.3 2.2 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zinc_ribbon_13 PF09855.9 CCM06483.1 - 0.053 13.7 0.3 8.5 6.6 0.0 2.5 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-RING_7 PF02591.15 CCM06483.1 - 0.061 13.5 5.1 4.8 7.5 0.0 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain zinc_ribbon_2 PF13240.6 CCM06483.1 - 0.14 11.9 9.9 4.6 7.1 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 CCM06483.1 - 0.16 12.1 4.6 12 6.1 0.1 2.7 2 1 0 2 2 2 0 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 CCM06483.1 - 0.18 11.9 1.4 18 5.5 0.0 2.5 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-ribbon_3 PF13248.6 CCM06483.1 - 0.19 11.2 7.3 3.3 7.3 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 CCM06483.1 - 0.28 10.7 5.8 12 5.5 0.0 2.6 2 1 0 2 2 2 0 TFIIB zinc-binding HypA PF01155.19 CCM06483.1 - 0.4 10.7 1.8 5.8 7.0 0.3 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA UPF0547 PF10571.9 CCM06483.1 - 0.64 10.2 9.3 2.9 8.1 0.6 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 Rubredoxin_2 PF18073.1 CCM06483.1 - 1.5 8.6 8.1 7 6.5 0.2 3.2 3 0 0 3 3 3 0 Rubredoxin metal binding domain zf-IS66 PF13005.7 CCM06483.1 - 2.6 8.5 6.3 33 5.0 0.1 3.3 3 0 0 3 3 3 0 zinc-finger binding domain of transposase IS66 A2L_zn_ribbon PF08792.10 CCM06483.1 - 3.5 7.4 5.5 5.8 6.8 0.1 2.8 3 0 0 3 3 3 0 A2L zinc ribbon domain DUF1451 PF07295.11 CCM06483.1 - 5.3 7.1 6.4 11 6.0 0.6 2.8 3 0 0 3 3 3 0 Zinc-ribbon containing domain zf-tcix PF14952.6 CCM06483.1 - 6.4 6.5 5.4 14 5.4 0.0 2.8 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding Nudix_N_2 PF14803.6 CCM06483.1 - 7 6.7 7.6 19 5.3 2.8 2.9 2 1 0 2 2 2 0 Nudix N-terminal Peptidase_M1 PF01433.20 CCM06484.1 - 1.8e-37 129.0 0.0 2.5e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 CCM06484.1 - 2.1e-28 98.6 0.0 4e-28 97.7 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 CCM06484.1 - 3.1e-19 69.9 0.0 4.9e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain SAP130_C PF16014.5 CCM06484.1 - 0.2 10.7 0.6 0.35 9.9 0.6 1.3 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Peptidase_M61 PF05299.12 CCM06484.1 - 0.27 11.7 2.7 3.6 8.0 2.7 2.4 1 1 0 1 1 1 0 M61 glycyl aminopeptidase ArfGap PF01412.18 CCM06485.1 - 1.7e-42 144.2 0.2 2.6e-42 143.6 0.2 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GET2 PF08690.10 CCM06486.1 - 1.8e-09 37.7 0.0 5.1e-09 36.2 0.0 1.7 1 1 0 1 1 1 1 GET complex subunit GET2 L51_S25_CI-B8 PF05047.16 CCM06487.1 - 2.2e-08 33.9 0.1 3.7e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain YL1 PF05764.13 CCM06488.1 - 2.6e-29 103.1 12.9 3.2e-29 102.8 12.9 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.11 CCM06488.1 - 9.1e-13 47.7 0.0 1.9e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain SpoVR PF04293.13 CCM06488.1 - 0.32 9.7 2.1 0.46 9.1 2.1 1.1 1 0 0 1 1 1 0 SpoVR like protein Hormone_3 PF00159.18 CCM06489.1 - 0.025 14.7 0.0 0.11 12.6 0.0 2.2 2 0 0 2 2 2 0 Pancreatic hormone peptide HisKA_4TM PF16926.5 CCM06491.1 - 0.29 10.7 4.9 0.12 12.0 0.8 2.0 2 0 0 2 2 2 0 Archaeal 4TM region of histidine kinase AAA PF00004.29 CCM06492.1 - 1.1e-40 139.1 0.0 8.1e-14 52.2 0.0 5.2 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_12 PF13087.6 CCM06492.1 - 3.9e-38 131.1 0.0 1.2e-37 129.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCM06492.1 - 3.4e-29 102.4 29.6 3.5e-25 89.3 0.0 6.5 6 0 0 6 6 6 2 AAA domain AAA_19 PF13245.6 CCM06492.1 - 8.7e-19 68.3 0.0 1.6e-07 31.8 0.0 5.8 5 2 0 5 5 4 3 AAA domain AAA_lid_6 PF17866.1 CCM06492.1 - 4.8e-18 65.1 2.4 7.9e-08 32.4 0.0 4.5 4 0 0 4 4 3 3 AAA lid domain AAA_30 PF13604.6 CCM06492.1 - 1.6e-16 60.6 13.3 0.00056 19.7 0.0 6.2 6 0 0 6 6 5 5 AAA domain AAA_22 PF13401.6 CCM06492.1 - 1.6e-13 51.1 3.8 0.06 13.6 0.0 7.3 5 3 0 5 5 4 3 AAA domain AAA_5 PF07728.14 CCM06492.1 - 2.1e-13 50.4 4.0 0.0057 16.7 0.0 5.3 5 0 0 5 5 5 3 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 CCM06492.1 - 9.1e-13 48.5 0.4 0.021 14.6 0.0 5.3 5 0 0 5 5 5 3 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 CCM06492.1 - 2.1e-12 46.9 0.8 0.046 13.1 0.0 4.9 5 1 0 5 5 4 4 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CCM06492.1 - 3.4e-09 36.7 0.1 0.095 12.4 0.0 4.7 4 0 0 4 4 4 2 IstB-like ATP binding protein RuvB_N PF05496.12 CCM06492.1 - 1e-07 31.9 0.1 0.68 9.7 0.0 4.6 4 0 0 4 4 4 2 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CCM06492.1 - 1.7e-07 31.8 3.8 0.68 10.5 0.1 5.2 4 0 0 4 4 4 2 AAA domain AAA_24 PF13479.6 CCM06492.1 - 3.4e-07 30.2 7.9 0.096 12.4 0.0 5.3 5 1 0 5 5 5 2 AAA domain Sigma54_activat PF00158.26 CCM06492.1 - 6.3e-07 29.2 0.6 1.7 8.3 0.0 5.3 5 1 0 5 5 5 1 Sigma-54 interaction domain RNA_helicase PF00910.22 CCM06492.1 - 6.9e-07 29.6 0.1 4.2 7.8 0.0 4.5 4 0 0 4 4 4 0 RNA helicase DUF2075 PF09848.9 CCM06492.1 - 2.9e-06 26.8 3.0 0.11 11.7 0.0 5.7 5 1 1 6 6 6 1 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 CCM06492.1 - 3.2e-06 26.8 1.6 0.4 10.2 0.0 5.0 5 0 0 5 5 5 1 P-loop containing dynein motor region ResIII PF04851.15 CCM06492.1 - 1.1e-05 25.6 0.1 0.026 14.5 0.0 4.6 5 0 0 5 5 4 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 CCM06492.1 - 0.00013 22.4 26.6 0.082 13.3 0.0 7.2 7 0 0 7 7 6 1 AAA ATPase domain PhoH PF02562.16 CCM06492.1 - 0.00017 21.1 1.5 3 7.3 0.0 4.7 5 0 0 5 5 4 1 PhoH-like protein TsaE PF02367.17 CCM06492.1 - 0.00066 19.7 0.5 1.6 8.7 0.0 3.8 4 0 0 4 4 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CCM06492.1 - 0.0011 18.9 1.8 5.9 6.8 0.0 4.6 4 0 0 4 4 4 0 NACHT domain KTI12 PF08433.10 CCM06492.1 - 0.0012 18.4 0.3 13 5.1 0.0 3.8 3 0 0 3 3 3 0 Chromatin associated protein KTI12 6PF2K PF01591.18 CCM06492.1 - 0.0021 17.4 0.0 0.097 12.0 0.0 2.8 3 0 0 3 3 3 1 6-phosphofructo-2-kinase SRP54 PF00448.22 CCM06492.1 - 0.0021 17.7 1.4 1.1 8.9 0.0 3.9 4 0 0 4 4 4 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 CCM06492.1 - 0.0024 18.0 27.3 0.42 10.8 0.1 6.3 6 0 0 6 6 5 3 AAA domain TniB PF05621.11 CCM06492.1 - 0.0036 16.7 0.2 7.9 5.8 0.0 4.7 5 1 1 6 6 5 0 Bacterial TniB protein AAA_25 PF13481.6 CCM06492.1 - 0.0066 16.0 4.3 2.1 7.8 0.0 4.6 4 0 0 4 4 4 1 AAA domain NTPase_1 PF03266.15 CCM06492.1 - 0.009 15.9 3.9 5.5 6.9 0.1 3.9 4 0 0 4 4 3 0 NTPase Rad17 PF03215.15 CCM06492.1 - 0.01 15.8 0.1 16 5.3 0.0 3.8 4 0 0 4 4 4 0 Rad17 P-loop domain MCM PF00493.23 CCM06492.1 - 0.016 14.3 0.1 0.68 9.0 0.0 2.9 3 0 0 3 3 3 0 MCM P-loop domain ATPase PF06745.13 CCM06492.1 - 0.021 14.2 9.2 1.8 7.8 0.0 4.9 5 0 0 5 5 5 0 KaiC AAA_3 PF07726.11 CCM06492.1 - 0.023 14.6 0.3 40 4.1 0.0 4.1 5 0 0 5 5 4 0 ATPase family associated with various cellular activities (AAA) Aminotran_1_2 PF00155.21 CCM06492.1 - 0.073 12.2 0.0 0.33 10.1 0.0 2.1 3 0 0 3 3 2 0 Aminotransferase class I and II NB-ARC PF00931.22 CCM06492.1 - 0.099 11.8 0.5 9.3 5.3 0.0 3.7 4 0 0 4 4 3 0 NB-ARC domain Roc PF08477.13 CCM06492.1 - 0.23 11.7 1.6 1 9.6 0.0 2.7 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase CbiA PF01656.23 CCM06492.1 - 0.24 11.5 4.4 32 4.6 0.0 4.1 5 0 0 5 5 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_32 PF13654.6 CCM06492.1 - 0.26 10.1 0.0 0.26 10.1 0.0 3.5 4 0 0 4 4 2 0 AAA domain ADK PF00406.22 CCM06492.1 - 0.54 10.4 2.7 57 3.8 0.0 4.0 4 0 0 4 4 3 0 Adenylate kinase AAA_28 PF13521.6 CCM06492.1 - 3.4 7.9 32.2 0.31 11.3 0.1 5.9 6 1 0 6 6 4 0 AAA domain Vanabin-2 PF11437.8 CCM06492.1 - 4.5 7.5 14.4 9.9 6.4 14.4 1.5 1 0 0 1 1 1 0 Vanadium-binding protein 2 ABC_tran PF00005.27 CCM06492.1 - 8.1 7.0 10.8 29 5.2 0.0 5.1 6 0 0 6 6 4 0 ABC transporter Sugar_tr PF00083.24 CCM06493.1 - 9e-94 314.9 20.6 3.8e-84 283.2 10.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CCM06493.1 - 6.3e-18 64.8 20.1 6.3e-18 64.8 20.1 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CCM06493.1 - 3.6e-05 22.4 2.1 3.6e-05 22.4 2.1 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CSTF_C PF14304.6 CCM06497.1 - 0.13 11.9 0.4 0.13 11.9 0.4 1.7 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal PKcGMP_CC PF16808.5 CCM06497.1 - 5.8 6.9 9.2 9.7 6.1 9.2 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ETX_MTX2 PF03318.13 CCM06498.1 - 1.6e-11 44.4 1.6 2.6e-11 43.7 1.6 1.4 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 CCM06498.1 - 1e-05 25.0 0.7 1.4e-05 24.5 0.7 1.2 1 0 0 1 1 1 1 Aerolysin toxin Fascin PF06268.13 CCM06498.1 - 0.00031 20.9 0.0 0.00071 19.8 0.0 1.5 1 0 0 1 1 1 1 Fascin domain ETX_MTX2 PF03318.13 CCM06500.1 - 6.9e-09 35.8 4.1 1.1e-08 35.1 4.1 1.3 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Fascin PF06268.13 CCM06500.1 - 6.5e-05 23.1 0.0 0.00015 21.9 0.0 1.6 1 0 0 1 1 1 1 Fascin domain Aerolysin PF01117.20 CCM06500.1 - 0.0034 16.7 1.0 0.0051 16.1 1.0 1.2 1 0 0 1 1 1 1 Aerolysin toxin Aldedh PF00171.22 CCM06502.1 - 1.7e-171 570.8 0.1 1.9e-171 570.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCM06502.1 - 0.039 13.4 0.0 2.2 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) DUF1275 PF06912.11 CCM06503.1 - 1.4e-27 96.9 15.0 1.6e-27 96.7 15.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Citrate_bind PF16114.5 CCM06504.1 - 1.8e-89 298.0 0.3 6.6e-89 296.1 0.2 1.9 2 0 0 2 2 2 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 CCM06504.1 - 3.1e-18 66.0 0.0 1.2e-15 57.4 0.0 2.6 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 CCM06504.1 - 1.9e-15 57.0 0.0 3.9e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 CCM06504.1 - 2.1e-13 50.8 0.0 5.2e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.10 CCM06504.1 - 1.5e-08 34.5 0.0 2.7e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 CCM06504.1 - 4.7e-05 23.2 0.0 0.00018 21.3 0.0 2.0 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain zf-Di19 PF05605.12 CCM06506.1 - 0.029 14.6 5.9 0.87 9.9 0.2 3.1 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding p47_phox_C PF08944.11 CCM06506.1 - 0.073 12.5 1.2 0.2 11.1 0.1 2.1 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain NinF PF05810.12 CCM06506.1 - 0.68 9.8 3.5 5.9 6.8 0.1 2.5 2 0 0 2 2 2 0 NinF protein Zn_Tnp_IS1 PF03811.13 CCM06506.1 - 1.5 8.6 7.2 0.96 9.2 0.2 3.3 3 0 0 3 3 3 0 InsA N-terminal domain Thioredoxin PF00085.20 CCM06507.1 - 3e-24 85.0 0.0 3.9e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CCM06507.1 - 7.2e-06 26.4 0.1 5.1e-05 23.7 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CCM06507.1 - 2.6e-05 24.0 0.0 3.2e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CCM06507.1 - 5.3e-05 23.5 0.0 0.00069 19.9 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 CCM06507.1 - 0.0002 20.8 0.0 0.00022 20.7 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 CCM06507.1 - 0.00023 21.1 0.0 0.00053 19.9 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCM06507.1 - 0.0022 17.7 0.1 0.039 13.7 0.0 2.0 1 1 1 2 2 2 1 Redoxin Glutaredoxin PF00462.24 CCM06507.1 - 0.048 13.9 0.0 0.083 13.1 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin HyaE PF07449.11 CCM06507.1 - 0.06 13.3 0.0 0.089 12.8 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TraF PF13728.6 CCM06507.1 - 0.12 12.1 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein gag-asp_proteas PF13975.6 CCM06509.1 - 0.16 12.5 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Pkinase PF00069.25 CCM06511.1 - 3.3e-21 75.8 0.0 1.4e-20 73.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06511.1 - 0.00016 21.1 0.2 0.0047 16.2 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 CCM06511.1 - 0.011 15.1 0.1 0.016 14.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM06511.1 - 0.043 13.4 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 CCM06511.1 - 0.073 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family EHN PF06441.12 CCM06512.1 - 1.5e-32 112.2 0.6 1.3e-31 109.2 0.0 2.3 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCM06512.1 - 5e-15 55.9 0.0 7.1e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM06512.1 - 1.4e-05 25.8 11.3 3.6e-05 24.5 11.2 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Polysacc_synt_C PF14667.6 CCM06512.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain ABC_tran PF00005.27 CCM06514.1 - 9.9e-28 97.4 0.1 2e-27 96.4 0.1 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CCM06514.1 - 5.1e-05 22.8 0.6 0.027 13.9 0.1 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 CCM06514.1 - 0.027 14.6 0.1 0.057 13.5 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_16 PF13191.6 CCM06514.1 - 0.028 14.8 2.6 0.036 14.5 0.3 2.3 3 0 0 3 3 3 0 AAA ATPase domain MMR_HSR1 PF01926.23 CCM06514.1 - 0.041 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 CCM06514.1 - 0.043 13.6 0.2 7.2 6.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CCM06514.1 - 0.11 12.2 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fungal_trans PF04082.18 CCM06514.1 - 0.17 10.9 0.2 0.39 9.7 0.0 1.7 2 0 0 2 2 2 0 Fungal specific transcription factor domain DctQ PF04290.12 CCM06514.1 - 0.93 9.4 3.1 7.7 6.4 0.8 2.5 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component ANAPC4_WD40 PF12894.7 CCM06516.1 - 0.00098 19.4 0.0 1.3 9.4 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCM06516.1 - 0.015 16.2 0.1 5.9 7.9 0.1 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat SIL1 PF16782.5 CCM06516.1 - 0.21 10.8 0.1 0.33 10.1 0.1 1.2 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 Epimerase PF01370.21 CCM06517.1 - 4.9e-21 75.3 0.0 7e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM06517.1 - 1.4e-14 54.3 0.0 1e-13 51.4 0.0 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CCM06517.1 - 6.7e-08 31.9 0.0 8.9e-08 31.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CCM06517.1 - 4.1e-06 26.1 0.0 7.1e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 CCM06517.1 - 5.1e-06 26.1 0.0 9e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CCM06517.1 - 2.3e-05 23.7 0.0 0.0057 15.8 0.0 2.3 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CCM06517.1 - 0.00097 18.4 0.0 0.0026 17.0 0.0 1.7 1 1 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 CCM06517.1 - 0.01 15.7 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding KR PF08659.10 CCM06517.1 - 0.017 15.0 0.2 0.35 10.7 0.2 2.2 1 1 0 1 1 1 0 KR domain Fungal_trans PF04082.18 CCM06519.1 - 3.5e-06 26.3 0.3 6.4e-06 25.4 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CCM06519.1 - 6.9e-06 26.1 10.1 1.3e-05 25.2 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AMP-binding PF00501.28 CCM06520.1 - 1.2e-30 106.5 0.0 3.1e-29 101.8 0.0 2.0 2 0 0 2 2 2 2 AMP-binding enzyme betaPIX_CC PF16523.5 CCM06522.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 betaPIX coiled coil RVT_1 PF00078.27 CCM06525.1 - 1.8e-24 86.5 0.0 3.4e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4939 PF16297.5 CCM06525.1 - 0.0032 17.3 0.0 0.0072 16.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) RSN1_7TM PF02714.15 CCM06528.1 - 3.5e-79 266.0 24.2 6.2e-79 265.1 24.2 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CCM06528.1 - 6.8e-37 127.4 0.0 1.1e-36 126.7 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CCM06528.1 - 1.1e-31 109.7 1.6 1.1e-31 109.7 1.6 2.8 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport UQ_con PF00179.26 CCM06529.1 - 6.5e-43 145.7 0.0 8.3e-43 145.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CCM06529.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 UEV domain GATA PF00320.27 CCM06531.1 - 1e-08 34.6 5.7 1.7e-08 33.9 5.7 1.4 1 0 0 1 1 1 1 GATA zinc finger SUIM_assoc PF16619.5 CCM06531.1 - 0.9 9.7 13.1 0.074 13.1 6.6 2.7 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Thiolase_N PF00108.23 CCM06532.1 - 6.3e-77 258.4 2.6 6.3e-77 258.4 2.6 2.2 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CCM06532.1 - 7.3e-47 158.0 0.3 1.6e-46 157.0 0.3 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CCM06532.1 - 0.0027 17.3 5.3 0.012 15.2 1.9 2.9 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CCM06532.1 - 0.067 13.1 1.4 15 5.5 0.1 2.9 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III TMEM82 PF15816.5 CCM06534.1 - 0.0079 15.2 0.5 0.014 14.4 0.5 1.3 1 0 0 1 1 1 1 Transmembrane protein 82 Como_LCP PF02247.16 CCM06535.1 - 0.037 12.6 0.1 0.078 11.6 0.1 1.4 1 0 0 1 1 1 0 Large coat protein Pyr_redox_3 PF13738.6 CCM06537.1 - 2.7e-24 86.0 0.0 2.5e-21 76.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CCM06537.1 - 3.1e-20 72.1 0.5 1.1e-16 60.4 0.2 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CCM06537.1 - 1e-19 70.9 0.0 2.2e-10 40.3 0.0 3.1 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CCM06537.1 - 5.6e-12 45.5 0.1 1.2e-08 34.5 0.2 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CCM06537.1 - 5.7e-10 39.6 1.7 0.0018 18.8 0.1 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM06537.1 - 5.1e-08 32.9 1.6 0.016 14.8 0.2 3.2 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CCM06537.1 - 2.5e-05 24.4 0.4 0.00048 20.3 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CCM06537.1 - 5.4e-05 22.6 0.5 0.00042 19.7 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CCM06537.1 - 8e-05 22.7 1.1 1.1 9.3 0.1 3.4 2 1 1 3 3 3 2 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CCM06537.1 - 0.00024 20.5 0.1 0.63 9.3 0.0 3.1 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CCM06537.1 - 0.0021 16.8 0.2 0.096 11.4 0.1 2.8 3 0 0 3 3 3 1 HI0933-like protein 2-Hacid_dh_C PF02826.19 CCM06537.1 - 0.0046 16.3 0.0 0.036 13.4 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 CCM06537.1 - 0.0048 16.0 0.5 0.059 12.4 0.7 2.5 3 1 0 3 3 3 1 FAD binding domain IlvN PF07991.12 CCM06537.1 - 0.009 15.6 0.4 0.63 9.6 0.1 2.4 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lycopene_cycl PF05834.12 CCM06537.1 - 0.04 13.0 0.1 0.075 12.1 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein 3HCDH_N PF02737.18 CCM06537.1 - 0.05 13.5 0.9 0.78 9.6 0.2 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Abhydrolase_1 PF00561.20 CCM06538.1 - 1.1e-14 54.7 0.0 1.8e-14 54.0 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM06538.1 - 3.8e-10 40.7 0.1 4.8e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM06538.1 - 2.6e-09 36.7 0.0 7.9e-07 28.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Thioesterase PF00975.20 CCM06538.1 - 0.022 14.9 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain DUF4519 PF15012.6 CCM06539.1 - 2.7 8.2 6.0 3.7 7.8 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) TOM20_plant PF06552.12 CCM06540.1 - 0.0059 16.4 0.0 0.0066 16.2 0.0 1.1 1 0 0 1 1 1 1 Plant specific mitochondrial import receptor subunit TOM20 DUF3328 PF11807.8 CCM06541.1 - 1.8e-14 54.1 1.3 3.9e-14 52.9 1.4 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) WD40 PF00400.32 CCM06543.1 - 1.5e-120 389.6 69.4 1.5e-08 35.1 0.1 15.0 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06543.1 - 3.1e-26 91.5 15.0 0.58 10.5 0.0 12.4 1 1 11 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CCM06543.1 - 7.2e-22 77.2 5.4 1.5 9.4 0.0 13.7 13 1 1 14 14 14 2 PQQ-like domain WD40_like PF17005.5 CCM06543.1 - 4.7e-19 68.8 0.0 0.13 11.5 0.0 8.9 6 2 3 9 9 9 6 WD40-like domain Nup160 PF11715.8 CCM06543.1 - 6.3e-19 68.0 7.4 1.2 7.7 0.0 12.2 9 2 3 13 13 13 7 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CCM06543.1 - 1.6e-14 53.3 17.5 0.0022 16.6 0.5 6.3 3 2 3 6 6 6 6 Cytochrome D1 heme domain FeThRed_A PF02941.15 CCM06543.1 - 1.2e-08 35.0 11.5 8.4 6.6 0.0 10.1 8 2 2 10 10 10 1 Ferredoxin thioredoxin reductase variable alpha chain Peptidase_S9_N PF02897.15 CCM06543.1 - 7.9e-08 31.5 5.9 0.11 11.3 0.0 7.5 2 2 4 7 7 7 1 Prolyl oligopeptidase, N-terminal beta-propeller domain AAA_16 PF13191.6 CCM06543.1 - 1e-06 29.3 0.2 2.2e-06 28.1 0.2 1.6 1 0 0 1 1 1 1 AAA ATPase domain Nucleoporin_N PF08801.11 CCM06543.1 - 2.4e-06 26.6 34.2 0.083 11.6 0.1 11.8 3 2 10 14 14 14 2 Nup133 N terminal like Ge1_WD40 PF16529.5 CCM06543.1 - 2.6e-05 23.3 3.3 1.9 7.4 0.0 7.5 2 2 7 10 10 10 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 CCM06543.1 - 7.4e-05 22.4 16.2 0.007 16.0 6.4 4.0 1 1 2 3 3 3 3 PQQ-like domain NACHT PF05729.12 CCM06543.1 - 0.00012 22.1 0.0 0.00031 20.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain PQQ PF01011.21 CCM06543.1 - 0.002 18.0 0.0 55 3.9 0.0 6.4 7 0 0 7 7 6 0 PQQ enzyme repeat bPH_4 PF06713.11 CCM06543.1 - 0.012 15.7 0.0 2.9 8.0 0.0 4.4 5 0 0 5 5 4 0 Bacterial PH domain AAA_22 PF13401.6 CCM06543.1 - 0.033 14.5 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CCM06543.1 - 0.039 13.1 0.0 0.075 12.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 CCM06543.1 - 0.05 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CCM06543.1 - 0.069 13.7 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Frtz PF11768.8 CCM06543.1 - 0.11 10.8 0.1 36 2.5 0.0 4.4 4 2 0 5 5 5 0 WD repeat-containing and planar cell polarity effector protein Fritz bacHORMA_2 PF18173.1 CCM06543.1 - 1.8 8.4 5.4 15 5.4 0.2 3.5 3 1 1 4 4 4 0 Bacterial HORMA domain 2 F-box PF00646.33 CCM06544.1 - 0.65 9.9 4.2 1.4 8.9 2.2 2.6 2 1 0 2 2 2 0 F-box domain Inhibitor_Mig-6 PF11555.8 CCM06545.1 - 0.47 10.6 2.4 0.35 11.0 0.5 1.7 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 FHA PF00498.26 CCM06547.1 - 1.2e-14 54.4 0.0 2e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 CCM06547.1 - 3.7e-11 42.5 9.1 7e-11 41.7 9.1 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 CCM06547.1 - 1.2e-08 35.1 10.1 2.2e-08 34.3 10.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CCM06547.1 - 7.2e-05 22.6 9.8 0.00012 21.8 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CCM06547.1 - 0.00012 22.3 7.2 0.00024 21.3 7.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CCM06547.1 - 0.00016 21.5 10.6 0.00027 20.7 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CCM06547.1 - 0.00029 20.8 2.0 0.00055 19.9 2.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 CCM06547.1 - 0.017 15.0 4.7 0.034 14.0 4.7 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.6 CCM06547.1 - 0.017 15.0 8.8 0.032 14.2 8.8 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CCM06547.1 - 0.02 15.0 1.8 0.05 13.8 1.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CCM06547.1 - 0.13 12.3 9.5 0.32 11.0 9.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CCM06547.1 - 0.48 10.1 4.9 0.81 9.4 4.9 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 CCM06547.1 - 0.56 10.1 6.4 1 9.2 6.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCM06547.1 - 3.3 7.7 8.6 6.9 6.6 8.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Ras PF00071.22 CCM06548.1 - 6.5e-34 116.9 0.2 7.7e-34 116.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCM06548.1 - 4.4e-25 88.2 0.2 8.3e-25 87.3 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCM06548.1 - 4.9e-08 32.6 0.1 6e-08 32.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM06548.1 - 1.7e-07 30.9 0.2 2.1e-07 30.5 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 CCM06548.1 - 0.014 14.2 0.4 1.3 7.8 0.0 2.1 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) TniB PF05621.11 CCM06548.1 - 0.02 14.3 0.0 1.4 8.2 0.0 2.3 2 1 0 2 2 2 0 Bacterial TniB protein G-alpha PF00503.20 CCM06548.1 - 0.047 12.8 2.3 0.14 11.3 0.1 2.3 2 1 1 3 3 3 0 G-protein alpha subunit polyprenyl_synt PF00348.17 CCM06549.1 - 3e-23 82.2 0.0 3.4e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase OPT PF03169.15 CCM06550.1 - 4.7e-78 263.4 16.1 5.1e-78 263.2 16.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Baculo_11_kDa PF06143.11 CCM06551.1 - 0.045 13.3 7.9 0.075 12.6 7.9 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family ODV-E18 PF10717.9 CCM06551.1 - 0.15 11.9 2.1 0.21 11.5 2.1 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 RhodobacterPufX PF11511.8 CCM06551.1 - 1.5 8.5 10.1 2.4 7.8 10.1 1.3 1 0 0 1 1 1 0 Intrinsic membrane protein PufX Shisa PF13908.6 CCM06551.1 - 2.9 8.1 6.8 3.9 7.7 6.8 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF3357 PF11837.8 CCM06551.1 - 3.3 8.2 5.3 5.5 7.5 5.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Orf78 PF06024.12 CCM06551.1 - 3.5 8.0 5.0 4.8 7.5 5.0 1.2 1 0 0 1 1 1 0 Orf78 (ac78) EphA2_TM PF14575.6 CCM06551.1 - 8.8 7.3 7.0 12 6.9 6.9 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Mucin PF01456.17 CCM06554.1 - 0.045 13.7 28.6 0.1 12.6 28.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Sporozoite_P67 PF05642.11 CCM06554.1 - 0.7 7.9 6.2 0.88 7.6 6.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FSA_C PF10479.9 CCM06554.1 - 2.1 6.4 11.4 2.9 5.9 11.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pex14_N PF04695.13 CCM06554.1 - 4.4 7.9 8.0 0.33 11.6 1.2 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region rve PF00665.26 CCM06557.1 - 5.8e-08 33.0 0.0 6.7e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 CCM06558.1 - 9.8e-15 54.7 0.0 1.6e-14 53.9 0.0 1.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Aldedh PF00171.22 CCM06559.1 - 6.7e-109 364.5 0.1 8.1e-109 364.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Crystall_3 PF08964.10 CCM06559.1 - 0.14 12.3 0.0 0.52 10.5 0.0 1.8 1 1 1 2 2 2 0 Beta/Gamma crystallin FtsK_gamma PF09397.10 CCM06562.1 - 0.071 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Ftsk gamma domain Glyco_hydro_3_C PF01915.22 CCM06563.1 - 6.1e-50 170.0 0.0 9.5e-50 169.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CCM06563.1 - 7.6e-19 67.6 0.2 1.5e-18 66.6 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 CCM06563.1 - 4.8e-12 45.9 0.0 7.8e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain polyprenyl_synt PF00348.17 CCM06564.1 - 3.3e-05 23.1 0.0 4.4e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase WD40 PF00400.32 CCM06569.1 - 3.3e-08 34.1 33.9 0.16 12.9 0.0 10.4 12 0 0 12 12 12 4 WD domain, G-beta repeat NACHT PF05729.12 CCM06569.1 - 3.1e-07 30.5 0.0 6.8e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 CCM06569.1 - 1.3e-06 28.6 2.1 3.3 8.1 0.0 5.7 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.6 CCM06569.1 - 0.00014 22.3 0.4 0.00044 20.7 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain APS_kinase PF01583.20 CCM06569.1 - 0.031 14.2 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA PF00004.29 CCM06569.1 - 0.033 14.6 0.0 0.15 12.5 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CCM06569.1 - 0.16 12.4 0.0 0.45 10.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Caveolin PF01146.17 CCM06569.1 - 0.16 11.9 0.0 0.51 10.3 0.0 1.8 1 0 0 1 1 1 0 Caveolin DUF5570 PF17731.1 CCM06569.1 - 0.23 11.6 1.3 0.89 9.7 0.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5570) CDC45 PF02724.14 CCM06569.1 - 4.2 5.5 15.0 6.4 4.9 15.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Ribonuc_2-5A PF06479.12 CCM06570.1 - 7.7e-44 148.9 0.4 1.3e-43 148.2 0.4 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 CCM06570.1 - 1.4e-38 132.8 0.0 5.2e-31 108.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06570.1 - 2.9e-18 66.1 0.0 2.6e-17 63.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCM06570.1 - 3.1e-05 23.0 0.0 0.00044 19.2 0.0 2.5 3 0 0 3 3 3 1 Fungal protein kinase PQQ PF01011.21 CCM06570.1 - 0.00073 19.4 0.0 0.0027 17.5 0.0 2.0 1 0 0 1 1 1 1 PQQ enzyme repeat Kdo PF06293.14 CCM06570.1 - 0.0068 15.8 0.1 0.011 15.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_2 PF13360.6 CCM06570.1 - 0.048 13.2 0.0 0.14 11.7 0.0 1.7 1 1 0 1 1 1 0 PQQ-like domain APH PF01636.23 CCM06570.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family His_biosynth PF00977.21 CCM06572.1 - 2.8e-06 27.0 0.1 4.3e-06 26.4 0.0 1.3 1 1 0 1 1 1 1 Histidine biosynthesis protein SSL_OB PF09199.10 CCM06573.1 - 0.079 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Staphylococcal superantigen-like OB-fold domain DUF1180 PF06679.12 CCM06574.1 - 0.17 12.3 6.3 0.12 12.8 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) SSP160 PF06933.11 CCM06574.1 - 2.6 6.2 9.0 3.2 5.8 9.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MGC-24 PF05283.11 CCM06574.1 - 5.7 7.4 7.1 0.98 9.9 2.6 1.9 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MFS_1 PF07690.16 CCM06575.1 - 2.8e-12 46.2 11.7 7.6e-12 44.8 11.3 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 CCM06575.1 - 0.19 11.2 7.2 0.12 11.8 2.5 2.6 2 1 0 2 2 2 0 Nodulin-like Peptidase_S10 PF00450.22 CCM06576.1 - 1.2e-55 189.7 0.0 1.5e-55 189.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.22 CCM06577.1 - 2.4e-50 172.2 4.2 3.2e-50 171.8 4.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase BTB PF00651.31 CCM06578.1 - 0.0001 22.5 0.0 0.00013 22.2 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Dimer_Tnp_hAT PF05699.14 CCM06579.1 - 0.004 16.9 0.1 0.0046 16.7 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Furin-like PF00757.20 CCM06581.1 - 0.034 14.0 3.2 0.063 13.2 3.2 1.4 1 0 0 1 1 1 0 Furin-like cysteine rich region Retrotran_gag_2 PF14223.6 CCM06582.1 - 0.00015 21.4 0.0 0.0002 21.0 0.0 1.2 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type RVT_2 PF07727.14 CCM06583.1 - 6.3e-77 258.5 0.0 9.2e-77 257.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCM06583.1 - 5.5e-22 78.2 0.0 1.6e-21 76.7 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CCM06583.1 - 9.2e-12 44.7 0.0 2.7e-11 43.2 0.0 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain rve_3 PF13683.6 CCM06583.1 - 0.00034 20.3 0.0 0.00079 19.2 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain eIF3g PF12353.8 CCM06583.1 - 0.0018 18.7 0.9 0.0036 17.7 0.9 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G Retrotran_gag_2 PF14223.6 CCM06583.1 - 0.0053 16.4 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type FAM195 PF14799.6 CCM06584.1 - 0.13 12.7 0.0 0.15 12.4 0.0 1.1 1 0 0 1 1 1 0 FAM195 family F-box-like PF12937.7 CCM06585.1 - 0.0014 18.5 0.1 0.0045 16.9 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM06585.1 - 0.0052 16.6 0.1 0.032 14.1 0.0 2.5 2 0 0 2 2 2 1 F-box domain DLIC PF05783.11 CCM06586.1 - 0.057 12.2 3.6 0.07 12.0 3.6 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) SAE2 PF08573.10 CCM06586.1 - 0.059 14.5 1.1 0.059 14.5 1.1 2.0 1 1 1 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF1115 PF06544.12 CCM06586.1 - 0.083 13.0 3.0 0.13 12.4 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) DUF4407 PF14362.6 CCM06586.1 - 1.2 8.4 8.3 1.4 8.2 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 CCM06586.1 - 3.1 7.5 11.8 4.1 7.1 11.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 CCM06586.1 - 4.3 6.9 7.2 6 6.4 7.2 1.2 1 0 0 1 1 1 0 Spt20 family Cupin_1 PF00190.22 CCM06587.1 - 2.9e-44 150.3 0.3 9.3e-22 77.3 0.1 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CCM06587.1 - 1.1e-29 102.0 0.5 4.6e-14 51.9 0.2 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CCM06587.1 - 9.1e-11 41.3 0.1 0.00025 20.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CCM06587.1 - 2e-07 31.0 0.3 5.7e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CCM06587.1 - 5.4e-06 26.4 0.0 9.4e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase 3-HAO PF06052.12 CCM06587.1 - 0.0055 16.4 0.0 0.082 12.6 0.0 2.1 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase DUF1971 PF09313.11 CCM06587.1 - 0.0067 16.4 0.0 1.6 8.8 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1971) Pirin_C PF05726.13 CCM06587.1 - 0.009 16.3 0.0 4.7 7.6 0.0 2.3 2 0 0 2 2 2 2 Pirin C-terminal cupin domain Cupin_4 PF08007.12 CCM06587.1 - 0.019 14.5 0.1 0.16 11.4 0.1 2.0 2 0 0 2 2 2 0 Cupin superfamily protein Ectoine_synth PF06339.12 CCM06587.1 - 0.035 14.3 0.0 4.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Ectoine synthase ARD PF03079.14 CCM06587.1 - 0.12 12.6 0.0 1.2 9.3 0.0 2.0 2 0 0 2 2 2 0 ARD/ARD' family cNMP_binding PF00027.29 CCM06587.1 - 0.15 12.1 0.1 1.1 9.4 0.0 2.4 3 0 0 3 3 3 0 Cyclic nucleotide-binding domain Meth_synt_2 PF01717.18 CCM06588.1 - 2.4e-14 53.3 0.0 4.5e-10 39.3 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CCM06588.1 - 0.0021 17.6 0.0 0.4 10.1 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain Ribosomal_L31 PF01197.18 CCM06589.1 - 0.15 12.3 0.2 0.33 11.2 0.2 1.5 1 1 0 1 1 1 0 Ribosomal protein L31 ApoO PF09769.9 CCM06590.1 - 7.2e-28 97.2 0.1 3.7e-27 94.9 0.0 2.0 2 0 0 2 2 2 1 Apolipoprotein O GST_N PF02798.20 CCM06590.1 - 2.2e-17 63.2 0.0 4.4e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCM06590.1 - 3.4e-14 53.0 0.0 7.9e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM06590.1 - 4.7e-11 42.8 0.0 9.3e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCM06590.1 - 5.2e-08 33.1 0.0 1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CCM06590.1 - 1.9e-05 24.6 0.0 4.6e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CCM06590.1 - 0.038 14.2 0.0 0.084 13.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-C2H2 PF00096.26 CCM06591.1 - 1.7e-10 40.7 16.5 0.001 19.4 3.1 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM06591.1 - 1.6e-07 31.6 14.5 0.0085 16.9 1.6 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CCM06591.1 - 1e-06 28.9 9.0 0.00037 20.8 0.3 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 CCM06591.1 - 7.9e-05 22.6 9.2 0.082 12.9 0.2 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CCM06591.1 - 0.012 15.8 1.9 27 5.2 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 CCM06591.1 - 0.016 15.5 4.8 0.049 13.9 3.5 2.4 2 1 1 3 3 3 0 C2H2-type zinc ribbon Fer4_9 PF13187.6 CCM06591.1 - 0.15 12.3 1.4 0.33 11.1 1.4 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain C1_1 PF00130.22 CCM06591.1 - 0.28 11.1 2.9 0.51 10.3 2.9 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_4 PF07975.12 CCM06591.1 - 0.44 10.8 3.3 1.2 9.5 3.3 1.8 1 0 0 1 1 1 0 TFIIH C1-like domain zf-C2HE PF16278.5 CCM06591.1 - 0.94 10.0 3.3 0.69 10.4 0.8 2.1 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Mut7-C PF01927.16 CCM06591.1 - 1.2 9.3 3.8 0.76 9.9 1.1 2.0 2 0 0 2 2 2 0 Mut7-C RNAse domain zf-LYAR PF08790.11 CCM06591.1 - 2 8.4 5.9 21 5.1 0.3 3.1 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Zn_ribbon_SprT PF17283.2 CCM06591.1 - 5.2 7.1 8.8 9.6 6.2 0.9 2.3 1 1 2 3 3 3 0 SprT-like zinc ribbon domain Pyr_redox_2 PF07992.14 CCM06592.1 - 4.4e-65 219.8 6.4 4.4e-65 219.8 6.4 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CCM06592.1 - 2.5e-42 143.6 0.3 2.5e-42 143.6 0.3 2.7 2 1 2 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CCM06592.1 - 2.3e-23 82.5 4.7 1.9e-19 70.0 1.8 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM06592.1 - 2.4e-11 43.5 3.4 3.9e-08 32.9 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CCM06592.1 - 7.1e-10 39.0 2.3 2.2e-05 24.6 0.1 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CCM06592.1 - 1e-09 38.0 6.4 9.1e-09 34.9 1.1 2.6 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 CCM06592.1 - 5e-09 36.0 0.1 5e-09 36.0 0.1 3.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM06592.1 - 5.6e-07 29.0 1.0 5.6e-07 29.0 1.0 4.1 3 1 1 4 4 4 1 FAD binding domain HI0933_like PF03486.14 CCM06592.1 - 1.3e-06 27.4 10.5 0.00084 18.2 0.1 4.1 4 0 0 4 4 4 2 HI0933-like protein AlaDh_PNT_C PF01262.21 CCM06592.1 - 7.9e-06 25.3 2.1 0.012 15.0 0.6 3.0 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 CCM06592.1 - 1.2e-05 24.7 1.6 0.018 14.2 0.1 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CCM06592.1 - 2e-05 23.9 3.1 0.0071 15.6 0.0 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 CCM06592.1 - 7.8e-05 22.1 10.1 0.05 12.8 0.1 3.4 3 0 0 3 3 3 3 FAD binding domain DAO PF01266.24 CCM06592.1 - 0.003 17.2 14.5 0.8 9.2 0.2 3.9 3 1 1 4 4 4 2 FAD dependent oxidoreductase THF_DHG_CYH_C PF02882.19 CCM06592.1 - 0.13 11.6 3.8 0.075 12.3 0.5 2.3 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GST_N PF02798.20 CCM06593.1 - 4.1e-20 71.9 0.8 3.8e-19 68.8 0.1 2.5 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCM06593.1 - 1.9e-14 53.8 0.0 3.2e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM06593.1 - 4.3e-14 52.5 0.2 8.1e-14 51.6 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCM06593.1 - 8e-13 48.5 0.0 1.7e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCM06593.1 - 2e-09 37.5 0.1 3.7e-09 36.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM06593.1 - 1.2e-06 28.5 0.1 2.6e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CCM06593.1 - 0.064 13.6 0.0 0.14 12.5 0.0 1.6 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein Atg8 PF02991.16 CCM06593.1 - 0.077 13.2 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like FAD_binding_3 PF01494.19 CCM06603.1 - 1.5e-09 37.6 0.0 2.9e-09 36.6 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CCM06603.1 - 4.9e-08 32.6 1.1 0.00061 19.1 0.3 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCM06603.1 - 1.4e-07 31.4 0.2 1e-06 28.6 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CCM06603.1 - 1.6e-07 30.8 0.4 6.9e-07 28.7 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CCM06603.1 - 9.2e-07 29.0 2.5 1.4e-06 28.5 1.2 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CCM06603.1 - 1.9e-05 25.1 1.5 0.012 16.1 0.4 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCM06603.1 - 5.2e-05 22.6 0.2 0.004 16.5 0.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CCM06603.1 - 6.2e-05 21.9 0.8 0.0053 15.5 0.3 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 CCM06603.1 - 0.00016 21.2 1.6 0.00028 20.4 1.6 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CCM06603.1 - 0.00082 18.8 0.2 0.091 12.0 0.2 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 CCM06603.1 - 0.0025 17.0 0.5 0.41 9.7 0.2 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Thi4 PF01946.17 CCM06603.1 - 0.0027 17.0 0.0 0.0047 16.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 CCM06603.1 - 0.0093 15.1 0.1 0.014 14.5 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 CCM06603.1 - 0.022 13.6 1.9 0.04 12.8 0.7 1.8 2 0 0 2 2 2 0 Tryptophan halogenase ThuA PF06283.11 CCM06604.1 - 7.9e-58 196.1 0.0 9e-58 195.9 0.0 1.0 1 0 0 1 1 1 1 Trehalose utilisation MINDY_DUB PF04424.13 CCM06605.1 - 7.7e-28 96.9 0.0 1.5e-27 95.9 0.0 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase LRR_6 PF13516.6 CCM06606.1 - 0.0024 17.8 0.1 6.5 7.1 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.7 CCM06606.1 - 0.012 16.0 0.7 0.16 12.4 0.2 2.6 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCM06606.1 - 0.022 14.5 0.8 0.13 12.0 0.3 2.3 2 0 0 2 2 2 0 Leucine rich repeat DUF2207 PF09972.9 CCM06607.1 - 0.086 11.6 0.0 0.092 11.5 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MFS_1 PF07690.16 CCM06609.1 - 4e-18 65.5 35.5 1.1e-15 57.4 16.4 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CCM06609.1 - 0.59 8.9 18.5 0.023 13.5 11.7 1.9 2 0 0 2 2 2 0 Sugar (and other) transporter DUF2370 PF10176.9 CCM06609.1 - 0.65 9.6 1.8 1.2 8.7 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Pkinase_fungal PF17667.1 CCM06612.1 - 6.9e-48 163.4 0.0 1e-47 162.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06612.1 - 0.00033 20.1 0.0 0.00058 19.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain p450 PF00067.22 CCM06613.1 - 5.7e-77 259.4 0.0 6.3e-77 259.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ICMT PF04140.14 CCM06614.1 - 8.5e-11 42.1 0.0 2.2e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CCM06614.1 - 2.4e-09 37.5 0.1 8.1e-09 35.8 0.0 1.8 1 1 1 2 2 2 1 Phospholipid methyltransferase adh_short PF00106.25 CCM06616.1 - 3.2e-06 26.7 0.0 0.0028 17.1 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase Rib_5-P_isom_A PF06026.14 CCM06617.1 - 3.1e-61 206.0 0.0 3.9e-61 205.6 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Tfb5 PF06331.12 CCM06618.1 - 5.5e-16 58.3 1.2 1e-14 54.3 0.6 2.0 2 0 0 2 2 2 2 Transcription factor TFIIH complex subunit Tfb5 MFS_1 PF07690.16 CCM06621.1 - 5.5e-47 160.4 33.4 3.6e-31 108.4 13.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCM06621.1 - 8.9e-09 34.2 0.6 0.00084 17.7 0.8 3.0 2 2 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 CCM06621.1 - 0.00017 20.6 19.4 0.11 11.3 2.8 3.4 2 2 1 3 3 3 3 MFS_1 like family DUF3487 PF11990.8 CCM06621.1 - 0.47 10.3 0.0 0.47 10.3 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3487) UbiA PF01040.18 CCM06623.1 - 1.1e-42 146.0 10.1 1.6e-42 145.6 10.1 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Peroxin-13_N PF04088.13 CCM06625.1 - 8.1e-43 146.2 0.0 1.2e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 CCM06625.1 - 2.9e-10 39.6 1.7 0.00079 19.0 2.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 CCM06625.1 - 6.5e-09 35.4 0.0 1.1e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCM06625.1 - 8.4e-08 32.0 0.1 1.7e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Keratin_2_head PF16208.5 CCM06625.1 - 0.076 13.2 18.6 0.15 12.2 18.6 1.5 1 0 0 1 1 1 0 Keratin type II head Gln-synt_C PF00120.24 CCM06626.1 - 1.4e-66 224.9 0.1 1.9e-66 224.4 0.1 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N_2 PF16952.5 CCM06626.1 - 0.059 13.2 0.0 0.69 9.8 0.0 2.6 2 1 0 2 2 2 0 Glutamine synthetase N-terminal domain Pmp3 PF01679.17 CCM06627.1 - 3.5e-23 81.5 10.0 4.6e-23 81.2 10.0 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Pkinase_fungal PF17667.1 CCM06628.1 - 3.7e-24 85.3 0.0 1.2e-23 83.6 0.0 1.7 1 1 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06628.1 - 0.00071 19.0 0.0 0.001 18.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CCM06628.1 - 0.0012 18.9 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family PTPRCAP PF15713.5 CCM06628.1 - 0.1 12.9 4.6 0.16 12.2 4.6 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Kdo PF06293.14 CCM06628.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDC45 PF02724.14 CCM06628.1 - 0.33 9.2 2.0 0.4 8.9 2.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 CCM06628.1 - 0.47 8.6 10.5 0.59 8.3 10.5 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 CCM06628.1 - 0.99 8.8 12.3 1.3 8.4 12.3 1.1 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 CCM06628.1 - 7.8 4.9 7.7 11 4.4 7.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Y_phosphatase PF00102.27 CCM06630.1 - 1.3e-49 168.9 0.0 1.4e-41 142.6 0.0 3.8 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Rhodanese PF00581.20 CCM06630.1 - 7.5e-08 32.9 0.0 3.9e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase3 PF13350.6 CCM06630.1 - 0.025 14.6 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Chromo PF00385.24 CCM06632.1 - 5e-08 32.7 0.0 1.5e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pex26 PF07163.12 CCM06633.1 - 0.029 13.7 0.0 0.029 13.7 0.0 1.8 2 0 0 2 2 2 0 Pex26 protein Fungal_trans_2 PF11951.8 CCM06634.1 - 1.5e-16 60.2 0.0 1.7e-16 60.1 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADSL_C PF10397.9 CCM06634.1 - 0.05 14.1 0.1 0.34 11.5 0.1 2.0 1 1 0 1 1 1 0 Adenylosuccinate lyase C-terminus V-SNARE_C PF12352.8 CCM06634.1 - 0.14 12.4 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus MitMem_reg PF13012.6 CCM06634.1 - 0.17 12.3 0.0 0.23 11.9 0.0 1.4 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function Zn_clus PF00172.18 CCM06635.1 - 2.5e-06 27.5 8.0 4.4e-06 26.7 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HPP PF04982.13 CCM06638.1 - 2.9e-41 140.5 7.5 2.9e-41 140.5 7.5 1.4 2 0 0 2 2 2 1 HPP family Lysis_col PF02402.16 CCM06638.1 - 0.21 11.3 1.5 0.44 10.3 1.5 1.5 1 0 0 1 1 1 0 Lysis protein Asp PF00026.23 CCM06639.1 - 1.2e-23 84.1 2.2 2.2e-20 73.3 2.2 2.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CCM06639.1 - 0.00033 21.2 0.8 0.0019 18.8 0.3 2.5 2 0 0 2 2 2 1 Aspartyl protease TAXi_N PF14543.6 CCM06639.1 - 0.0069 16.6 0.4 2.8 8.1 0.0 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 CCM06639.1 - 0.0074 16.8 0.1 0.25 11.9 0.0 2.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp PF00026.23 CCM06640.1 - 4.9e-05 22.9 0.2 5.5e-05 22.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Peroxidase_2 PF01328.17 CCM06641.1 - 1.8e-46 159.0 0.0 2.4e-46 158.6 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 YL1 PF05764.13 CCM06643.1 - 5.1 7.1 23.9 9.4 6.3 23.9 1.3 1 0 0 1 1 1 0 YL1 nuclear protein ETX_MTX2 PF03318.13 CCM06644.1 - 5e-10 39.5 4.0 7.5e-10 39.0 4.0 1.3 1 1 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 CCM06644.1 - 2.6e-05 23.6 1.1 3.3e-05 23.3 1.1 1.2 1 0 0 1 1 1 1 Aerolysin toxin Pkinase_fungal PF17667.1 CCM06645.1 - 3.2e-05 22.9 0.0 3.9e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase DUF4114 PF13448.6 CCM06647.1 - 0.12 13.2 0.0 0.19 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4114) PA-IIL PF07472.11 CCM06648.1 - 0.0066 16.7 0.3 0.22 11.9 0.0 2.1 2 0 0 2 2 2 1 Fucose-binding lectin II (PA-IIL) Glyco_hydro_65C PF03633.15 CCM06648.1 - 0.095 12.6 0.2 0.25 11.3 0.0 1.8 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, C-terminal domain WD40 PF00400.32 CCM06649.1 - 2.3e-10 40.9 0.2 2.3e-10 40.9 0.2 2.9 2 1 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06649.1 - 0.014 15.7 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 CCM06651.1 - 6.1e-07 29.2 5.1 1.1e-06 28.4 5.1 1.4 1 0 0 1 1 1 1 F-box-like ATG16 PF08614.11 CCM06651.1 - 0.024 14.9 1.7 0.032 14.5 1.7 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TRAF_BIRC3_bd PF16673.5 CCM06651.1 - 0.14 12.0 4.5 0.23 11.3 0.3 2.1 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain F-box PF00646.33 CCM06651.1 - 0.3 11.0 3.6 0.87 9.5 3.6 1.8 1 1 0 1 1 1 0 F-box domain DUF4140 PF13600.6 CCM06651.1 - 3.2 8.3 5.1 33 5.0 5.1 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) F-box-like PF12937.7 CCM06652.1 - 1.7e-10 40.6 1.0 4.2e-10 39.4 1.0 1.7 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 CCM06652.1 - 0.49 10.2 3.3 1.5 8.7 0.0 3.5 4 0 0 4 4 4 0 Leucine rich repeat RRN3 PF05327.11 CCM06652.1 - 2.9 6.3 9.9 11 4.4 7.6 2.3 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 SH3_1 PF00018.28 CCM06653.1 - 0.006 16.2 0.2 0.0099 15.5 0.2 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CCM06653.1 - 0.037 13.9 0.1 0.057 13.3 0.1 1.3 1 0 0 1 1 1 0 Variant SH3 domain Mito_carr PF00153.27 CCM06654.1 - 3e-16 59.1 0.0 3.2e-16 59.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Mito_carr PF00153.27 CCM06655.1 - 6.3e-22 77.3 0.3 6.7e-22 77.2 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein Glyco_hydro_72 PF03198.14 CCM06656.1 - 1e-96 324.0 0.3 2.4e-52 178.1 0.4 2.1 2 0 0 2 2 2 2 Glucanosyltransferase X8 PF07983.13 CCM06656.1 - 4.3e-17 62.6 2.2 1e-16 61.4 2.2 1.6 1 0 0 1 1 1 1 X8 domain Flavin_Reduct PF01613.18 CCM06658.1 - 1.3e-21 77.2 0.0 1.9e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Trimer_CC PF08954.11 CCM06659.1 - 0.013 15.0 0.5 0.062 12.9 0.1 2.3 1 1 1 2 2 2 0 Trimerisation motif DmpG_comm PF07836.11 CCM06659.1 - 0.052 13.1 0.0 0.16 11.5 0.0 1.8 1 0 0 1 1 1 0 DmpG-like communication domain MACPF PF01823.19 CCM06659.1 - 0.077 13.1 3.5 0.091 12.8 0.1 2.3 2 1 0 2 2 2 0 MAC/Perforin domain DUF3228 PF11539.8 CCM06659.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3228) CHDCT2 PF08074.11 CCM06659.1 - 0.14 12.4 0.6 0.37 11.0 0.1 1.9 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain Acetyltransf_9 PF13527.7 CCM06660.1 - 0.0063 16.6 0.1 0.015 15.4 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCM06660.1 - 0.19 12.2 0.0 0.39 11.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RVT_1 PF00078.27 CCM06661.1 - 0.0028 17.2 0.0 0.019 14.5 0.0 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCM06663.1 - 1.2e-30 105.5 0.0 2e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCM06663.1 - 1.6e-28 99.0 0.0 2.7e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCM06663.1 - 3.1e-21 75.9 0.2 6.7e-21 74.8 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PyrI PF01948.18 CCM06664.1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain Mtd_N PF18454.1 CCM06664.1 - 0.15 12.1 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Major tropism determinant N-terminal domain NACHT PF05729.12 CCM06665.1 - 4e-05 23.6 0.2 0.0002 21.3 0.2 2.1 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CCM06665.1 - 7.2e-05 23.2 0.1 0.0002 21.8 0.1 1.8 1 0 0 1 1 1 1 AAA ATPase domain BLYB PF05289.11 CCM06665.1 - 0.0023 18.1 0.7 0.013 15.7 0.6 2.1 2 0 0 2 2 2 1 Borrelia hemolysin accessory protein NB-ARC PF00931.22 CCM06665.1 - 0.012 14.8 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Fanconi_A PF03511.14 CCM06665.1 - 0.047 13.6 1.7 0.068 13.1 0.0 2.2 3 0 0 3 3 3 0 Fanconi anaemia group A protein PMSR PF01625.21 CCM06666.1 - 2.2e-58 196.8 0.2 2.7e-58 196.5 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase p450 PF00067.22 CCM06667.1 - 3.1e-54 184.5 0.0 3.9e-54 184.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RVT_1 PF00078.27 CCM06668.1 - 6.7e-24 84.6 0.2 1.1e-23 83.9 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_7 PF12775.7 CCM06668.1 - 0.087 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Aldedh PF00171.22 CCM06669.1 - 1.4e-08 33.7 0.1 1.5e-08 33.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family adh_short PF00106.25 CCM06670.1 - 2.6e-24 85.8 0.0 4.2e-21 75.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06670.1 - 8.3e-14 51.7 0.0 2.7e-13 50.0 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06670.1 - 6.9e-09 35.9 0.1 1.3e-08 35.0 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CCM06670.1 - 1.1e-05 25.0 0.0 2e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CCM06670.1 - 0.028 13.8 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CCM06670.1 - 0.056 12.6 0.1 0.18 11.0 0.1 1.9 1 1 0 1 1 1 0 Male sterility protein Sulfatase_C PF14707.6 CCM06671.1 - 0.0058 17.4 0.0 0.0077 17.0 0.0 1.1 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Caleosin PF05042.13 CCM06671.1 - 0.0074 16.2 0.0 0.0082 16.1 0.0 1.2 1 0 0 1 1 1 1 Caleosin related protein FOXP-CC PF16159.5 CCM06673.1 - 2.9e-05 24.6 5.7 0.021 15.4 0.3 3.4 1 1 2 3 3 3 3 FOXP coiled-coil domain zf-C2H2_12 PF18658.1 CCM06673.1 - 1.1 8.9 0.0 1.1 8.9 0.0 3.1 2 1 2 4 4 4 0 Zinc-finger C2H2-type CHORD PF04968.12 CCM06673.1 - 1.2 9.9 6.4 35 5.2 0.1 2.6 2 1 0 2 2 2 0 CHORD Nop10p PF04135.12 CCM06675.1 - 0.068 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family MFS_1 PF07690.16 CCM06676.1 - 1.9e-26 92.8 7.7 2.3e-26 92.6 7.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PUCC PF03209.15 CCM06676.1 - 0.15 11.1 8.9 0.27 10.2 8.9 1.4 1 1 0 1 1 1 0 PUCC protein DUF4282 PF14110.6 CCM06676.1 - 2.9 8.7 9.9 2.1 9.1 7.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) LYRIC PF15686.5 CCM06677.1 - 0.0069 16.0 0.1 0.011 15.4 0.1 1.2 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family Bax1-I PF01027.20 CCM06677.1 - 0.11 12.3 6.5 0.15 11.9 6.5 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 p450 PF00067.22 CCM06679.1 - 4.6e-34 117.9 0.0 5.9e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 B12-binding PF02310.19 CCM06679.1 - 0.18 11.8 0.0 23 5.0 0.0 2.4 2 0 0 2 2 2 0 B12 binding domain p450 PF00067.22 CCM06680.1 - 2.4e-49 168.4 0.0 6.3e-49 167.0 0.0 1.5 2 0 0 2 2 2 1 Cytochrome P450 DUF3435 PF11917.8 CCM06682.1 - 3.1e-33 115.3 0.9 5.7e-32 111.2 0.9 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3435) DUF4543 PF15076.6 CCM06682.1 - 0.19 11.9 2.1 5 7.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4543) AIP3 PF03915.13 CCM06684.1 - 4e-90 302.9 10.5 4.5e-90 302.7 10.5 1.0 1 0 0 1 1 1 1 Actin interacting protein 3 ISG65-75 PF11727.8 CCM06684.1 - 0.002 17.4 0.3 0.0033 16.7 0.3 1.5 1 0 0 1 1 1 1 Invariant surface glycoprotein ApoO PF09769.9 CCM06684.1 - 0.043 13.8 1.3 0.19 11.7 0.1 2.2 1 1 0 2 2 2 0 Apolipoprotein O DUF2399 PF09664.10 CCM06684.1 - 0.068 13.1 0.2 0.36 10.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2399) DUF1664 PF07889.12 CCM06684.1 - 0.087 12.9 5.6 0.29 11.2 5.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Muted PF14942.6 CCM06684.1 - 0.11 12.9 10.8 0.1 12.9 5.3 2.4 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein V_ATPase_I PF01496.19 CCM06684.1 - 0.17 9.8 1.8 0.24 9.3 1.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WXG100 PF06013.12 CCM06684.1 - 0.18 12.0 4.5 2.8 8.2 0.3 2.9 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Med28 PF11594.8 CCM06684.1 - 0.23 11.5 6.1 0.18 11.9 1.7 2.6 2 1 1 3 3 3 0 Mediator complex subunit 28 EMP24_GP25L PF01105.24 CCM06684.1 - 0.24 11.3 4.5 1.2 9.0 4.4 2.3 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Syntaxin-6_N PF09177.11 CCM06684.1 - 0.28 11.7 7.3 1.5 9.5 2.7 2.9 2 1 1 3 3 3 0 Syntaxin 6, N-terminal SR-25 PF10500.9 CCM06684.1 - 0.66 9.5 7.4 3.5 7.2 1.0 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein BEX PF04538.12 CCM06684.1 - 0.95 10.1 5.6 0.55 10.8 0.3 2.4 2 1 0 2 2 2 0 Brain expressed X-linked like family NPV_P10 PF05531.12 CCM06684.1 - 1.2 9.7 6.2 11 6.5 5.3 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein ZapB PF06005.12 CCM06684.1 - 6.6 7.3 18.7 31 5.1 9.7 3.3 2 1 0 2 2 2 0 Cell division protein ZapB Inhibitor_I66 PF16850.5 CCM06685.1 - 5e-07 29.7 0.1 9.7e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I66 RicinB_lectin_2 PF14200.6 CCM06685.1 - 7e-05 23.5 0.3 0.0019 18.9 0.1 2.6 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like DUF3712 PF12505.8 CCM06685.1 - 7.3e-05 23.0 0.0 0.00031 21.0 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3712) Pkinase PF00069.25 CCM06689.1 - 1.2e-26 93.6 0.0 2.1e-25 89.6 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06689.1 - 4e-10 39.4 0.0 0.00014 21.2 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase RIO1 PF01163.22 CCM06689.1 - 0.014 15.0 0.1 0.028 14.0 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Tir_receptor_C PF07489.11 CCM06690.1 - 0.012 15.6 0.1 0.015 15.3 0.1 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus p450 PF00067.22 CCM06692.1 - 5e-11 42.0 0.1 5e-11 42.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 COesterase PF00135.28 CCM06693.1 - 5.3e-46 157.6 0.0 6e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CCM06693.1 - 0.0017 18.3 0.2 0.0029 17.5 0.2 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CCM06694.1 - 1.1e-09 37.8 0.1 5e-09 35.6 0.1 1.8 1 1 0 1 1 1 1 Carboxylesterase family Flavokinase PF01687.17 CCM06695.1 - 4.6e-22 78.4 0.0 6e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Fungal_lectin PF07938.12 CCM06696.1 - 0.00012 21.5 0.1 0.00013 21.5 0.1 1.1 1 0 0 1 1 1 1 Fungal fucose-specific lectin Glyco_hydro_76 PF03663.14 CCM06696.1 - 0.044 13.3 0.1 0.044 13.3 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 76 ABC_tran PF00005.27 CCM06697.1 - 1.7e-29 103.1 0.0 3.3e-29 102.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CCM06697.1 - 9.4e-24 84.5 13.0 1.4e-23 84.0 13.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CCM06697.1 - 1.3e-05 24.8 2.1 0.0037 16.7 0.4 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 CCM06697.1 - 0.013 15.6 0.1 0.038 14.1 0.1 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 CCM06697.1 - 0.018 15.1 0.0 0.066 13.3 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CCM06697.1 - 0.035 14.5 0.2 0.076 13.4 0.2 1.6 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 CCM06697.1 - 0.035 13.8 0.3 1 9.1 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 CCM06697.1 - 0.062 12.9 0.1 0.29 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCM06697.1 - 0.077 12.7 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 CCM06697.1 - 0.1 12.4 1.2 4.7 6.9 0.3 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Ost5 PF05251.12 CCM06697.1 - 0.73 10.1 4.9 3.4 8.0 0.5 2.8 2 1 0 2 2 2 0 Oligosaccharyltransferase subunit 5 AAA_23 PF13476.6 CCM06697.1 - 3.4 8.1 4.7 2.1 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Esterase_phd PF10503.9 CCM06698.1 - 0.11 12.0 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase DUF3435 PF11917.8 CCM06699.1 - 4.9e-15 55.4 0.5 6.8e-12 45.0 0.0 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF3435) CPSase_C PF18302.1 CCM06699.1 - 0.99 10.0 2.5 2 9.1 0.5 2.6 2 0 0 2 2 2 0 Carbamoyl phosphate synthetase C-terminal domain Pkinase_fungal PF17667.1 CCM06704.1 - 2.1e-15 56.4 0.0 3.4e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase ATG16 PF08614.11 CCM06704.1 - 0.044 14.0 0.4 0.059 13.6 0.4 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF5601 PF18151.1 CCM06704.1 - 0.078 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) E1_4HB PF16191.5 CCM06704.1 - 0.15 12.3 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle FOXP-CC PF16159.5 CCM06705.1 - 7.1e-06 26.6 5.5 0.031 14.9 0.1 3.2 2 1 1 3 3 3 2 FOXP coiled-coil domain PLL PF18587.1 CCM06705.1 - 0.0062 16.7 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 PTX/LNS-Like (PLL) domain zf-C2H2 PF00096.26 CCM06705.1 - 0.0064 16.9 0.1 0.0064 16.9 0.1 3.5 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM06705.1 - 0.11 13.4 0.1 0.11 13.4 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Ribosomal_L17 PF01196.19 CCM06706.1 - 0.014 16.3 8.8 21 6.1 0.3 5.1 1 1 3 4 4 4 0 Ribosomal protein L17 Anophelin PF10731.9 CCM06706.1 - 3.7 7.5 12.9 23 4.9 0.2 4.6 1 1 2 3 3 3 0 Thrombin inhibitor from mosquito DUF3328 PF11807.8 CCM06707.1 - 5.6e-52 176.7 0.1 7.3e-52 176.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) HSF_DNA-bind PF00447.17 CCM06712.1 - 2.9e-18 66.3 0.0 5.3e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding DUF1152 PF06626.12 CCM06713.1 - 0.049 12.8 0.0 0.086 12.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1152) His_biosynth PF00977.21 CCM06713.1 - 0.091 12.2 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 Histidine biosynthesis protein Pkinase_fungal PF17667.1 CCM06714.1 - 5.4e-22 78.1 0.0 7.1e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06714.1 - 2.1e-11 43.7 0.0 3.3e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06714.1 - 2.9e-08 33.3 0.0 4.5e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM06714.1 - 0.0009 19.2 0.2 0.0097 15.8 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM06714.1 - 0.0083 15.7 0.1 0.035 13.7 0.0 2.0 3 0 0 3 3 3 1 Choline/ethanolamine kinase RIO1 PF01163.22 CCM06714.1 - 0.027 14.1 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 CCM06714.1 - 0.03 13.7 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family COQ7 PF03232.13 CCM06716.1 - 3.3e-65 219.0 1.0 3e-53 180.1 0.4 2.1 1 1 1 2 2 2 2 Ubiquinone biosynthesis protein COQ7 NDUF_B4 PF07225.12 CCM06717.1 - 4e-05 23.5 0.1 4.5e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) DUF423 PF04241.15 CCM06717.1 - 0.046 13.9 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF423) G-patch PF01585.23 CCM06718.1 - 8.1e-14 51.2 1.8 1.4e-13 50.5 1.8 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CCM06718.1 - 1.5e-06 28.1 1.8 4.9e-06 26.5 1.8 1.9 1 0 0 1 1 1 1 G-patch domain zf-C2H2_jaz PF12171.8 CCM06718.1 - 6.3e-05 23.1 0.4 0.00013 22.1 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 CCM06718.1 - 0.0098 15.6 0.7 0.015 15.0 0.7 1.3 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 CCM06718.1 - 0.042 14.2 0.1 0.077 13.3 0.1 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCM06718.1 - 0.089 13.3 0.4 0.089 13.3 0.4 1.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM06718.1 - 0.1 13.5 0.2 0.25 12.3 0.2 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met PF12874.7 CCM06718.1 - 0.12 12.8 0.5 0.21 12.0 0.5 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type RED_N PF07808.13 CCM06718.1 - 0.15 11.7 9.1 0.022 14.4 4.0 2.0 2 0 0 2 2 2 0 RED-like protein N-terminal region Aldedh PF00171.22 CCM06719.1 - 5.7e-180 598.7 1.0 6.4e-180 598.6 1.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CCM06719.1 - 0.038 13.5 0.0 5 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) DUF5133 PF17196.4 CCM06719.1 - 0.19 11.9 0.7 0.65 10.2 0.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF5133) p450 PF00067.22 CCM06720.1 - 3.9e-48 164.3 0.0 4.3e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4867 PF16161.5 CCM06720.1 - 0.14 11.6 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4867) WD40 PF00400.32 CCM06722.1 - 4.3e-17 62.2 3.9 8.4e-06 26.4 0.0 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06722.1 - 5.4e-05 23.4 0.0 4.1 7.8 0.0 4.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CCM06722.1 - 0.075 12.0 0.0 0.72 8.8 0.0 2.4 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Sugar_tr PF00083.24 CCM06723.1 - 1.4e-32 113.1 26.6 9.4e-32 110.4 26.6 2.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM06723.1 - 3.9e-30 105.0 31.5 7.9e-30 104.0 31.5 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily B12D PF06522.11 CCM06725.1 - 0.52 10.1 3.1 2 8.2 2.3 2.3 1 1 1 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit GFO_IDH_MocA PF01408.22 CCM06726.1 - 2.4e-22 80.0 0.0 4.7e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CCM06726.1 - 0.00048 20.1 0.0 0.027 14.5 0.0 3.0 2 1 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.24 CCM06726.1 - 0.037 14.5 0.0 0.34 11.4 0.0 2.2 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain SspH PF08141.12 CCM06726.1 - 0.079 13.1 0.2 10 6.4 0.0 2.4 2 0 0 2 2 2 0 Small acid-soluble spore protein H family Methyltransf_25 PF13649.6 CCM06727.1 - 0.00024 21.8 0.0 0.019 15.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain DapH_N PF08503.10 CCM06727.1 - 0.23 11.7 0.1 0.37 11.1 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal DUF5127 PF17168.4 CCM06728.1 - 4.9e-41 141.0 3.7 6.6e-41 140.6 3.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 CCM06728.1 - 3.8e-10 39.2 0.2 6.8e-10 38.4 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) Glyco_hydr_116N PF12215.8 CCM06728.1 - 0.0026 17.3 0.2 0.0035 16.9 0.2 1.2 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Caudo_TAP PF02413.17 CCM06728.1 - 0.17 12.0 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK CFEM PF05730.11 CCM06730.1 - 2.3e-10 40.4 15.1 3.6e-10 39.8 15.1 1.3 1 0 0 1 1 1 1 CFEM domain MGC-24 PF05283.11 CCM06730.1 - 0.11 13.0 13.8 0.15 12.5 13.8 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin ORC6 PF05460.13 CCM06732.1 - 8.9 5.5 13.9 16 4.7 13.9 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Copper-fist PF00649.18 CCM06733.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Copper fist DNA binding domain DUF4939 PF16297.5 CCM06734.1 - 0.0035 17.2 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Trypan_PARP PF05887.11 CCM06734.1 - 1.1 9.2 11.7 1.5 8.8 11.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3493 PF11998.8 CCM06740.1 - 0.061 13.5 0.3 0.15 12.2 0.3 1.6 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 FtsX PF02687.21 CCM06740.1 - 5.7 7.5 13.7 4 8.0 4.7 2.1 2 0 0 2 2 2 0 FtsX-like permease family ABC_membrane PF00664.23 CCM06744.1 - 1e-11 45.0 10.6 1.4e-09 38.0 0.0 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_2 PF07724.14 CCM06747.1 - 1.2e-50 172.0 0.0 6.2e-47 159.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CCM06747.1 - 2.3e-33 114.2 6.9 1.8e-32 111.4 1.1 3.7 3 0 0 3 3 3 1 AAA lid domain ClpB_D2-small PF10431.9 CCM06747.1 - 2.2e-23 82.1 2.0 3.8e-23 81.3 0.3 2.4 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CCM06747.1 - 2.1e-22 80.0 0.0 1.6e-11 44.8 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CCM06747.1 - 2.1e-15 56.9 0.2 1.6e-07 31.4 0.0 3.9 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 CCM06747.1 - 1.3e-14 54.1 6.5 1.6e-11 44.1 0.5 4.1 4 0 0 4 4 3 1 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 CCM06747.1 - 1.2e-09 38.8 8.4 2.3e-05 24.8 0.0 5.6 5 2 0 6 6 6 2 AAA ATPase domain AAA_22 PF13401.6 CCM06747.1 - 1.2e-08 35.3 0.0 0.0061 16.8 0.0 4.0 2 1 1 3 3 3 2 AAA domain Sigma54_activat PF00158.26 CCM06747.1 - 2.8e-08 33.6 0.0 5e-05 23.1 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.21 CCM06747.1 - 5.5e-06 25.9 0.0 0.012 15.0 0.0 2.8 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CCM06747.1 - 7.4e-06 25.8 0.0 0.0092 15.7 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein TIP49 PF06068.13 CCM06747.1 - 4e-05 23.0 0.5 0.31 10.2 0.0 3.1 2 1 1 3 3 3 2 TIP49 P-loop domain TniB PF05621.11 CCM06747.1 - 5.6e-05 22.6 0.0 0.081 12.3 0.0 3.5 3 1 0 3 3 2 1 Bacterial TniB protein AAA_18 PF13238.6 CCM06747.1 - 0.00011 22.7 0.0 0.27 11.8 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CCM06747.1 - 0.00021 21.1 0.0 0.027 14.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CCM06747.1 - 0.00023 21.5 0.1 1.4 9.4 0.0 2.8 3 0 0 3 3 2 2 RNA helicase AAA_33 PF13671.6 CCM06747.1 - 0.00068 19.8 0.0 0.23 11.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CCM06747.1 - 0.0022 17.3 0.0 0.33 10.2 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 CCM06747.1 - 0.0035 17.3 0.0 0.98 9.3 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 CCM06747.1 - 0.0049 16.4 0.0 2.6 7.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Laminin_II PF06009.12 CCM06747.1 - 0.0067 16.4 2.5 0.016 15.2 0.7 2.4 2 0 0 2 2 2 1 Laminin Domain II ABC_tran PF00005.27 CCM06747.1 - 0.018 15.6 0.6 3.7 8.1 0.0 3.2 3 0 0 3 3 3 0 ABC transporter Torsin PF06309.11 CCM06747.1 - 0.042 14.0 0.0 0.49 10.5 0.0 2.4 3 0 0 3 3 2 0 Torsin AAA_29 PF13555.6 CCM06747.1 - 0.059 13.1 0.0 11 5.8 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF815 PF05673.13 CCM06747.1 - 0.087 12.0 0.1 8.2 5.5 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF815) Spc7 PF08317.11 CCM06747.1 - 0.094 11.6 7.4 0.19 10.6 7.4 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein TsaE PF02367.17 CCM06747.1 - 0.097 12.7 0.0 6.8 6.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 CCM06747.1 - 0.1 12.5 0.0 10 6.0 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase Roc PF08477.13 CCM06747.1 - 0.14 12.4 0.0 11 6.3 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PV-1 PF06637.11 CCM06747.1 - 0.34 9.7 10.4 0.57 8.9 10.4 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Exonuc_VII_L PF02601.15 CCM06747.1 - 0.46 10.0 4.3 1 8.9 4.3 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit ABC_tran_CTD PF16326.5 CCM06747.1 - 0.54 10.5 18.8 2.9 8.2 4.5 4.2 3 1 1 4 4 3 0 ABC transporter C-terminal domain 5_nucleotid PF05761.14 CCM06747.1 - 1.7 7.5 3.5 2.9 6.7 3.5 1.3 1 0 0 1 1 1 0 5' nucleotidase family AAA_23 PF13476.6 CCM06747.1 - 9.1 6.7 14.0 22 5.5 0.0 3.7 3 1 0 3 3 2 0 AAA domain zf-CHCC PF10276.9 CCM06748.1 - 5.6e-12 45.5 1.0 8.5e-12 44.9 1.0 1.3 1 0 0 1 1 1 1 Zinc-finger domain Pkinase PF00069.25 CCM06749.1 - 8.1e-52 176.2 0.0 5.5e-51 173.5 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06749.1 - 8.3e-24 84.3 0.0 1.4e-23 83.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LsmAD PF06741.13 CCM06749.1 - 2.3 8.8 3.9 5.7 7.6 3.9 1.5 1 0 0 1 1 1 0 LsmAD domain Helicase_C PF00271.31 CCM06752.1 - 2.9e-10 40.5 0.0 6.8e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Mfa1 PF17445.2 CCM06752.1 - 0.05 13.6 0.9 0.16 12.0 0.9 1.8 1 0 0 1 1 1 0 Mating factor A1 FoP_duplication PF13865.6 CCM06752.1 - 1.9 9.1 10.7 1.7 9.3 6.6 2.6 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 PspA_IM30 PF04012.12 CCM06753.1 - 5.7e-05 22.8 0.0 6.3e-05 22.7 0.0 1.0 1 0 0 1 1 1 1 PspA/IM30 family Baculo_PEP_C PF04513.12 CCM06753.1 - 0.0013 18.8 2.1 0.0017 18.4 2.1 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 CCM06753.1 - 0.011 15.7 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HTH_11 PF08279.12 CCM06753.1 - 0.021 14.7 1.7 5.9 6.9 0.1 3.2 1 1 1 3 3 3 0 HTH domain Fib_alpha PF08702.10 CCM06753.1 - 0.027 14.7 0.0 0.036 14.3 0.0 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 CCM06753.1 - 0.028 14.8 0.2 0.57 10.6 0.2 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.8 CCM06753.1 - 0.031 14.4 0.5 4.2 7.5 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF3755 PF12579.8 CCM06753.1 - 0.036 13.7 0.5 10 5.8 0.1 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3755) SKA2 PF16740.5 CCM06753.1 - 0.04 13.7 0.1 6.3 6.6 0.0 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Spc7 PF08317.11 CCM06753.1 - 0.051 12.5 0.0 0.058 12.3 0.0 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein WEMBL PF05701.11 CCM06753.1 - 0.076 11.7 0.0 0.08 11.6 0.0 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DUF5082 PF16888.5 CCM06753.1 - 0.099 12.9 0.2 0.22 11.8 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) ADIP PF11559.8 CCM06753.1 - 0.12 12.4 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 CCM06753.1 - 0.16 12.0 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ribosomal_L29 PF00831.23 CCM06753.1 - 0.59 10.1 5.2 4.2 7.4 0.2 2.9 1 1 2 3 3 3 0 Ribosomal L29 protein NUMOD3 PF07460.11 CCM06754.1 - 0.0079 16.4 1.4 93 3.4 0.1 4.0 4 0 0 4 4 4 0 NUMOD3 motif (2 copies) DUF5126 PF17166.4 CCM06754.1 - 0.24 11.3 4.5 6.3 6.7 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5126) Pyridoxal_deC PF00282.19 CCM06759.1 - 2.3e-18 66.1 0.0 8.4e-13 47.8 0.0 3.1 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain Pkinase_fungal PF17667.1 CCM06760.1 - 1.5e-20 73.4 0.2 2.6e-20 72.6 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06760.1 - 1.8e-11 43.9 0.1 2.9e-11 43.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM06760.1 - 1.7e-08 34.1 0.0 2.4e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCM06760.1 - 0.0026 17.7 0.1 0.0055 16.7 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CCM06760.1 - 0.016 14.8 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 CCM06760.1 - 0.022 14.1 0.0 0.046 13.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CCM06760.1 - 0.051 13.2 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family F-box PF00646.33 CCM06761.1 - 5e-05 23.1 1.7 8.9e-05 22.3 0.2 2.3 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CCM06761.1 - 0.028 14.3 0.2 0.098 12.6 0.2 1.9 1 0 0 1 1 1 0 F-box-like Prenyltransf PF01255.19 CCM06762.1 - 6.7e-73 244.9 0.0 8.6e-73 244.6 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase zf-CCHC PF00098.23 CCM06767.1 - 1.2e-05 25.1 2.9 1.2e-05 25.1 2.9 1.8 2 0 0 2 2 2 1 Zinc knuckle eIF3g PF12353.8 CCM06767.1 - 0.00085 19.7 1.3 0.0017 18.7 1.3 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_2 PF13696.6 CCM06767.1 - 0.00085 19.1 5.3 0.0015 18.3 5.3 1.4 1 0 0 1 1 1 1 Zinc knuckle DUF4722 PF15849.5 CCM06767.1 - 0.13 12.0 0.8 0.2 11.4 0.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4722) zf-CCHC_5 PF14787.6 CCM06767.1 - 0.4 10.4 3.0 2.2 8.1 3.2 2.0 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger MIS13 PF08202.11 CCM06771.1 - 2.8e-28 99.1 5.5 2.8e-28 99.1 5.5 2.0 2 0 0 2 2 2 1 Mis12-Mtw1 protein family Cytochrom_C PF00034.21 CCM06772.1 - 5.9e-10 40.2 0.0 8.2e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CCM06772.1 - 5.3e-08 33.1 1.5 3.8e-07 30.3 1.5 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CCM06772.1 - 0.00059 19.5 0.9 0.0028 17.4 0.9 2.1 1 1 0 1 1 1 1 Cytochrome c-550 domain AAA_16 PF13191.6 CCM06773.1 - 0.092 13.1 0.0 0.69 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain RHSP PF07999.11 CCM06773.1 - 0.15 10.8 0.1 2.6 6.8 0.0 2.0 2 0 0 2 2 2 0 Retrotransposon hot spot protein Mid2 PF04478.12 CCM06774.1 - 0.009 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor ABC1 PF03109.16 CCM06775.1 - 6.2e-27 94.1 0.1 1.2e-26 93.2 0.1 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CCM06775.1 - 0.016 15.1 0.5 0.16 11.9 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family adh_short PF00106.25 CCM06776.1 - 5e-54 182.7 1.1 6.3e-54 182.4 1.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06776.1 - 1.3e-49 168.9 0.7 1.5e-49 168.7 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06776.1 - 7.8e-09 35.7 2.7 1.4e-08 34.9 2.7 1.3 1 1 0 1 1 1 1 KR domain DUF3024 PF11225.8 CCM06777.1 - 0.0037 17.5 7.7 63 3.9 0.0 5.7 3 2 3 6 6 6 0 Protein of unknown function (DUF3024) DUF3461 PF11944.8 CCM06777.1 - 0.073 13.2 6.3 0.39 10.8 0.9 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3461) Ribosomal_L17 PF01196.19 CCM06777.1 - 2.3 9.2 8.5 22 6.0 2.9 2.9 1 1 1 2 2 2 0 Ribosomal protein L17 DUF3328 PF11807.8 CCM06778.1 - 1.5e-28 100.1 0.5 1.7e-28 99.9 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) UDPGT PF00201.18 CCM06778.1 - 0.23 10.2 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase DUF3328 PF11807.8 CCM06779.1 - 4.8e-11 42.9 0.0 5.2e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Auxin_BP PF02041.16 CCM06780.1 - 0.17 11.5 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Auxin binding protein DUF4939 PF16297.5 CCM06781.1 - 0.00039 20.3 0.0 0.00092 19.1 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) RVT_2 PF07727.14 CCM06782.1 - 8.9e-29 100.8 0.0 1.2e-28 100.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CCM06782.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 GAG-pre-integrase domain rve PF00665.26 CCM06782.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Neurensin PF14927.6 CCM06783.1 - 0.21 11.3 4.5 9.2 6.0 4.5 2.2 1 1 0 1 1 1 0 Neurensin DUF975 PF06161.11 CCM06783.1 - 0.9 9.3 7.7 4.6 7.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF975) Orf78 PF06024.12 CCM06783.1 - 8.5 6.7 10.8 3.6 7.9 0.1 2.3 1 1 1 2 2 2 0 Orf78 (ac78) Pkinase_fungal PF17667.1 CCM06785.1 - 9.3e-23 80.6 0.0 5.1e-22 78.2 0.0 1.9 1 1 0 1 1 1 1 Fungal protein kinase zf-C2H2 PF00096.26 CCM06787.1 - 3e-20 71.5 17.8 6.5e-06 26.3 1.3 6.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CCM06787.1 - 1.3e-12 47.5 24.6 4.6e-06 26.8 0.3 6.0 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CCM06787.1 - 1.6e-09 37.8 31.1 0.00032 21.3 1.1 6.8 7 0 0 7 7 5 5 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CCM06787.1 - 2.5e-08 34.1 12.5 0.0015 18.8 0.1 4.3 4 0 0 4 4 4 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 CCM06787.1 - 3.9e-08 33.8 18.2 0.04 14.6 0.1 6.0 3 1 3 6 6 6 4 FOXP coiled-coil domain zf_ZIC PF18366.1 CCM06787.1 - 3.4e-07 30.3 11.1 0.0002 21.4 0.9 4.8 6 0 0 6 6 6 2 Zic proteins zinc finger domain zf-C2H2_6 PF13912.6 CCM06787.1 - 9.2e-06 25.5 12.8 0.16 12.0 1.1 5.6 5 0 0 5 5 5 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCM06787.1 - 7.4e-05 22.4 1.0 7.4e-05 22.4 1.0 3.1 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.6 CCM06787.1 - 0.0056 16.5 6.9 2.5 8.1 0.1 4.3 4 0 0 4 4 4 2 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 CCM06787.1 - 0.0069 16.7 9.5 0.0079 16.5 0.3 3.8 4 0 0 4 4 3 1 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 CCM06787.1 - 0.047 14.1 1.2 0.14 12.6 1.2 1.8 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger DUF629 PF04780.12 CCM06787.1 - 0.18 10.3 3.5 6.8 5.1 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF629) zf-met PF12874.7 CCM06787.1 - 0.67 10.4 3.6 4.3 7.9 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 CCM06787.1 - 2.7 7.8 7.9 0.82 9.5 0.3 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf_Hakai PF18408.1 CCM06787.1 - 4.8 7.0 6.5 5.3 6.8 0.0 3.6 4 0 0 4 4 4 0 C2H2 Hakai zinc finger domain CoxIIa PF08113.11 CCM06789.1 - 0.96 9.3 4.0 4.6 7.1 1.0 2.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IIa family RTA1 PF04479.13 CCM06794.1 - 1.9e-53 181.2 0.5 1.9e-53 181.2 0.5 1.6 2 0 0 2 2 2 1 RTA1 like protein DUF1772 PF08592.11 CCM06794.1 - 7.7 6.8 9.8 7 7.0 1.5 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) Bunya_G2 PF03563.13 CCM06795.1 - 0.028 13.7 0.8 0.033 13.4 0.8 1.0 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 RVT_1 PF00078.27 CCM06796.1 - 9.4e-15 54.7 0.0 1.2e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Bd3614-deam PF14439.6 CCM06797.1 - 0.067 13.3 0.2 0.077 13.1 0.2 1.1 1 0 0 1 1 1 0 Bd3614-like deaminase Helicase_C PF00271.31 CCM06798.1 - 1.2e-07 32.1 0.0 8.1e-07 29.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CCM06798.1 - 1.9e-06 26.9 0.0 3.6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 CCM06798.1 - 0.015 15.3 0.0 0.069 13.2 0.0 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit C_Hendra PF16821.5 CCM06798.1 - 0.05 13.5 0.5 0.52 10.2 0.0 2.3 2 0 0 2 2 2 0 C protein from hendra and measles viruses CdiI_3 PF18616.1 CCM06800.1 - 0.013 15.4 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 CDI immunity proteins OPT PF03169.15 CCM06802.1 - 5.3e-121 405.2 21.4 6.4e-121 404.9 21.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Aldo_ket_red PF00248.21 CCM06803.1 - 2.5e-67 227.2 0.0 2.8e-67 227.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TcpF PF06340.11 CCM06803.1 - 0.08 11.8 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F F-box-like PF12937.7 CCM06804.1 - 0.0022 17.9 0.4 0.0067 16.3 0.4 1.9 1 0 0 1 1 1 1 F-box-like HpcH_HpaI PF03328.14 CCM06807.1 - 3.7e-24 85.1 0.0 8.3e-18 64.3 0.0 2.1 2 0 0 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family PK PF00224.21 CCM06807.1 - 0.0097 14.8 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain HET PF06985.11 CCM06808.1 - 2.2e-27 96.2 0.0 4.2e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DcpS_C PF11969.8 CCM06810.1 - 2e-26 92.7 0.1 3.2e-26 92.0 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 CCM06810.1 - 1.9e-24 86.5 0.0 3.2e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal Peroxidase_2 PF01328.17 CCM06811.1 - 4.2e-49 167.6 0.0 7.3e-49 166.8 0.0 1.4 1 0 0 1 1 1 1 Peroxidase, family 2 DUF29 PF01724.16 CCM06813.1 - 0.16 12.2 1.9 8.1 6.7 1.4 2.4 1 1 1 2 2 2 0 Domain of unknown function DUF29 RT_RNaseH_2 PF17919.1 CCM06814.1 - 1.8e-10 40.7 0.0 2.6e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCM06814.1 - 7.2e-07 29.5 0.0 1.1e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DDE_Tnp_IS1595 PF12762.7 CCM06814.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 2 0 0 2 2 2 0 ISXO2-like transposase domain MFS_1 PF07690.16 CCM06822.1 - 2e-26 92.8 27.1 1.1e-19 70.6 20.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Wzy_C PF04932.15 CCM06822.1 - 0.00028 20.5 2.0 0.086 12.5 0.4 2.6 2 0 0 2 2 2 2 O-Antigen ligase FPN1 PF06963.12 CCM06822.1 - 0.013 14.0 0.0 2.8 6.4 0.0 2.2 2 0 0 2 2 2 0 Ferroportin1 (FPN1) LPD18 PF18832.1 CCM06822.1 - 0.17 12.0 0.1 24 5.1 0.0 2.5 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 18 DUF4939 PF16297.5 CCM06823.1 - 0.00022 21.0 0.0 0.00035 20.4 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.17 CCM06823.1 - 0.062 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Retrotransposon gag protein RVT_2 PF07727.14 CCM06824.1 - 2.8e-38 131.9 0.0 3.7e-38 131.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CCM06824.1 - 6.8e-15 55.3 0.0 2.1e-14 53.8 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.6 CCM06824.1 - 3.1e-10 39.8 0.0 8e-10 38.4 0.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_2 PF14223.6 CCM06824.1 - 2.9e-08 33.5 0.0 1.1e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type rve_3 PF13683.6 CCM06824.1 - 0.017 14.9 0.0 0.09 12.6 0.0 2.1 2 0 0 2 2 2 0 Integrase core domain DUF4939 PF16297.5 CCM06825.1 - 4.4e-05 23.3 0.0 7.6e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.17 CCM06825.1 - 0.074 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon gag protein DUF2393 PF09624.10 CCM06826.1 - 0.021 14.8 2.8 0.021 14.8 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2393) Choline_transpo PF04515.12 CCM06826.1 - 0.39 9.9 11.6 0.12 11.5 6.7 1.9 1 1 1 2 2 2 0 Plasma-membrane choline transporter DUF1189 PF06691.11 CCM06826.1 - 2.5 7.6 14.5 0.94 9.0 5.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) DIOX_N PF14226.6 CCM06830.1 - 8.6e-15 55.5 0.1 2.2e-14 54.2 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCM06830.1 - 2.3e-13 50.5 0.0 4.3e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3328 PF11807.8 CCM06831.1 - 2.8e-36 125.4 3.7 3.1e-36 125.2 3.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Flavokinase PF01687.17 CCM06832.1 - 9.9e-24 83.8 0.0 1.3e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Fungal_lectin PF07938.12 CCM06833.1 - 5.8e-07 29.2 0.3 1.2e-06 28.2 0.3 1.4 1 1 0 1 1 1 1 Fungal fucose-specific lectin AMP-binding PF00501.28 CCM06837.1 - 1.8e-27 96.0 0.0 8.1e-27 93.9 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme DUF3328 PF11807.8 CCM06839.1 - 7.7e-10 38.9 0.0 1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF29 PF01724.16 CCM06840.1 - 0.029 14.6 1.6 4.8 7.4 1.1 2.4 1 1 1 2 2 2 0 Domain of unknown function DUF29 RsbRD_N PF14361.6 CCM06840.1 - 0.39 11.4 3.8 0.41 11.4 0.1 2.7 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain Cwf_Cwc_15 PF04889.12 CCM06840.1 - 3.9 7.1 13.5 8 6.1 13.5 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pes-10 PF07149.11 CCM06840.1 - 5 6.1 8.1 7.7 5.5 8.1 1.3 1 0 0 1 1 1 0 Pes-10 CTP_transf_1 PF01148.20 CCM06842.1 - 0.078 12.7 6.5 0.083 12.6 6.5 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family TraL PF07178.11 CCM06842.1 - 0.085 13.3 4.8 0.8 10.2 0.8 2.0 1 1 1 2 2 2 0 TraL protein Spo7 PF03907.13 CCM06842.1 - 0.43 10.0 2.8 0.54 9.7 2.8 1.3 1 0 0 1 1 1 0 Spo7-like protein ATP-synt_8 PF00895.20 CCM06842.1 - 1.2 9.6 9.5 0.42 11.1 2.7 2.3 2 1 0 2 2 2 0 ATP synthase protein 8 DUF2418 PF10332.9 CCM06842.1 - 1.4 9.5 4.5 1.4 9.4 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) Ndc1_Nup PF09531.10 CCM06842.1 - 2.9 6.5 8.8 3.1 6.4 8.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DHHC PF01529.20 CCM06842.1 - 3.5 7.7 6.3 5 7.2 6.3 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF3328 PF11807.8 CCM06845.1 - 2.2e-36 125.7 3.9 2.6e-36 125.4 3.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) AMNp_N PF10423.9 CCM06845.1 - 0.06 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus MFS_1 PF07690.16 CCM06847.1 - 2.8e-46 158.1 36.8 5.2e-30 104.6 14.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCM06847.1 - 1.3e-09 37.0 2.4 0.0029 16.0 1.8 3.6 2 2 2 4 4 4 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 CCM06847.1 - 0.0004 19.4 21.2 0.039 12.8 1.5 3.5 2 2 1 3 3 3 3 MFS_1 like family DUF3487 PF11990.8 CCM06847.1 - 0.51 10.2 0.0 0.51 10.2 0.0 3.4 4 1 1 5 5 5 0 Protein of unknown function (DUF3487) p450 PF00067.22 CCM06848.1 - 9.5e-46 156.5 0.0 1.1e-45 156.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 CCM06853.1 - 2.3e-83 280.5 25.4 2.9e-83 280.2 25.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM06853.1 - 1.6e-32 112.8 41.3 6.2e-24 84.6 27.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily F-box-like PF12937.7 CCM06855.1 - 1.3e-06 28.2 0.1 4.4e-06 26.5 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM06855.1 - 0.54 10.2 3.4 13 5.8 0.1 3.1 3 0 0 3 3 3 0 F-box domain LRR_4 PF12799.7 CCM06855.1 - 5 7.7 6.1 8.9 6.9 1.1 3.3 2 2 0 2 2 2 0 Leucine Rich repeats (2 copies) zf-C2H2 PF00096.26 CCM06857.1 - 0.0022 18.4 0.1 0.33 11.5 0.0 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCM06857.1 - 0.0038 18.0 0.3 1.5 9.8 0.0 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CCM06857.1 - 0.051 13.4 1.2 1.8 8.4 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 CCM06858.1 - 0.25 12.3 1.8 5.2 8.2 0.2 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCM06858.1 - 0.35 11.4 6.4 0.8 10.3 0.1 3.3 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 CCM06858.1 - 0.63 9.9 4.0 7.7 6.4 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain adh_short PF00106.25 CCM06864.1 - 4.1e-12 46.0 0.0 1.1e-10 41.3 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CCM06864.1 - 1.9e-08 34.1 0.1 3.9e-08 33.1 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CCM06864.1 - 3.8e-08 33.4 0.0 5.7e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 KR domain p450 PF00067.22 CCM06866.1 - 4.2e-41 141.2 0.0 4.9e-28 98.1 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Mcl1_mid PF12341.8 CCM06867.1 - 1.2e-87 294.0 0.0 3.9e-87 292.4 0.0 1.9 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 CCM06867.1 - 3.9e-15 56.0 10.9 8.2e-06 26.5 0.4 6.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06867.1 - 5.9e-11 42.5 0.1 0.01 16.1 0.0 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain AA_kinase PF00696.28 CCM06867.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Amino acid kinase family Frtz PF11768.8 CCM06867.1 - 0.26 9.5 0.0 0.39 9.0 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Pap_E4 PF02711.14 CCM06867.1 - 2.1 9.3 4.0 0.74 10.8 0.3 2.2 2 0 0 2 2 2 0 E4 protein RrnaAD PF00398.20 CCM06868.1 - 2.4e-22 79.3 0.0 3.5e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF747 PF05346.11 CCM06869.1 - 1.2e-79 268.1 0.3 1.6e-79 267.7 0.3 1.4 1 1 0 1 1 1 1 Eukaryotic membrane protein family SMC_N PF02463.19 CCM06869.1 - 3.8e-43 147.5 1.7 5.7e-43 146.9 1.7 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CCM06869.1 - 1.4e-23 83.4 0.0 5e-23 81.6 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CCM06869.1 - 1.2e-06 28.5 1.4 1.2e-06 28.5 1.4 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system GPS2_interact PF15784.5 CCM06869.1 - 0.11 12.9 0.0 0.11 12.9 0.0 5.4 5 1 0 5 5 5 0 G-protein pathway suppressor 2-interacting domain DUF4239 PF14023.6 CCM06869.1 - 0.69 9.6 0.0 0.69 9.6 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4239) ICAP-1_inte_bdg PF10480.9 CCM06870.1 - 1.2 9.1 8.5 2.1 8.3 8.5 1.3 1 0 0 1 1 1 0 Beta-1 integrin binding protein DUF5546 PF17700.1 CCM06872.1 - 0.085 13.2 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5546) DUF3328 PF11807.8 CCM06873.1 - 0.34 10.7 0.8 0.34 10.7 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Internalin_N PF12354.8 CCM06873.1 - 3.1 7.9 6.2 0.69 10.0 0.6 2.2 1 1 1 2 2 2 0 Bacterial adhesion/invasion protein N terminal CTP_transf_like PF01467.26 CCM06878.1 - 3.1e-08 33.9 0.0 7.8e-08 32.6 0.0 1.7 1 1 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 CCM06878.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 FAD synthetase p450 PF00067.22 CCM06879.1 - 3.1e-68 230.6 0.0 3.9e-68 230.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase_fungal PF17667.1 CCM06880.1 - 5e-28 98.0 0.0 6.7e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 CCM06880.1 - 0.0012 18.3 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain p450 PF00067.22 CCM06881.1 - 6.6e-57 193.3 0.0 7.1e-57 193.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Wx5_PLAF3D7 PF09688.10 CCM06885.1 - 0.073 13.1 1.1 0.088 12.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) baeRF_family10 PF18854.1 CCM06885.1 - 0.094 13.0 0.3 0.094 13.0 0.3 1.6 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 Acetyltransf_9 PF13527.7 CCM06885.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Amidoligase_2 PF12224.8 CCM06886.1 - 0.022 14.4 0.0 0.025 14.2 0.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme UvrA_inter PF17760.1 CCM06886.1 - 0.11 12.5 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 UvrA interaction domain Mito_fiss_reg PF05308.11 CCM06886.1 - 0.16 12.0 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator RVT_1 PF00078.27 CCM06890.1 - 1.1e-23 84.0 0.0 1.4e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ABC2_membrane_3 PF12698.7 CCM06891.1 - 0.053 12.6 3.5 0.075 12.1 3.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein SUR7 PF06687.12 CCM06891.1 - 0.15 11.7 3.2 0.2 11.2 3.2 1.1 1 0 0 1 1 1 0 SUR7/PalI family BRF1 PF07741.13 CCM06895.1 - 0.046 14.1 0.0 0.069 13.5 0.0 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain DnaB PF00772.21 CCM06896.1 - 0.029 14.4 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain WD40 PF00400.32 CCM06898.1 - 2.5e-106 344.6 57.7 1.9e-08 34.8 0.1 14.2 13 1 1 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06898.1 - 9e-21 74.0 23.0 0.41 11.0 0.3 12.1 1 1 11 13 13 13 7 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 CCM06898.1 - 7e-14 51.4 27.5 0.0058 15.4 0.3 9.2 1 1 9 10 10 10 6 Nup133 N terminal like CHAP PF05257.16 CCM06898.1 - 4.7e-12 46.3 27.9 0.17 12.5 0.0 11.3 2 2 8 12 12 12 3 CHAP domain PD40 PF07676.12 CCM06898.1 - 1.7e-11 43.7 0.5 21 5.2 0.0 11.5 14 0 0 14 14 14 0 WD40-like Beta Propeller Repeat PQQ_3 PF13570.6 CCM06898.1 - 1.3e-09 38.2 5.5 4.2 8.0 0.0 10.4 11 2 2 13 13 12 1 PQQ-like domain Nup160 PF11715.8 CCM06898.1 - 2.6e-09 36.3 19.7 4.6 5.8 0.0 10.8 9 3 3 12 12 12 5 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CCM06898.1 - 6.4e-07 28.2 13.2 0.22 10.0 0.3 6.1 3 2 3 7 7 7 4 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 CCM06898.1 - 4.2e-06 26.0 7.8 19 4.1 0.0 9.4 2 2 7 11 11 11 0 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 CCM06898.1 - 0.00021 20.5 1.6 2.1 7.3 0.0 4.7 2 1 2 5 5 5 2 VID27 C-terminal WD40-like domain DUF2375 PF09558.10 CCM06898.1 - 0.0035 17.3 0.4 56 3.9 0.0 6.4 8 1 1 9 9 8 0 Protein of unknown function (DUF2375) WD40_like PF17005.5 CCM06898.1 - 0.0097 15.3 0.0 22 4.2 0.0 4.8 4 2 1 5 5 5 0 WD40-like domain CXCXC PF03128.14 CCM06898.1 - 0.04 14.4 2.2 17 6.1 0.1 4.4 3 0 0 3 3 3 0 CXCXC repeat SoxZ PF08770.11 CCM06898.1 - 0.13 12.0 0.0 48 3.8 0.0 4.2 4 1 0 4 4 4 0 Sulphur oxidation protein SoxZ Frtz PF11768.8 CCM06898.1 - 0.16 10.3 0.0 34 2.6 0.0 4.3 6 1 0 6 6 6 0 WD repeat-containing and planar cell polarity effector protein Fritz FG-GAP_2 PF14312.6 CCM06898.1 - 4 7.8 38.4 41 4.5 0.0 11.6 13 0 0 13 13 13 0 FG-GAP repeat RVT_1 PF00078.27 CCM06899.1 - 1.1e-18 67.6 0.0 1.3e-18 67.3 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCM06900.1 - 2.1e-09 37.2 0.1 7.5e-09 35.5 0.0 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 CCM06900.1 - 0.00082 19.0 0.3 0.0016 18.0 0.3 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family EFP_N PF08207.12 CCM06900.1 - 0.01 15.8 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Peptidase_M15_4 PF13539.6 CCM06900.1 - 0.068 13.7 0.4 0.26 11.8 0.2 2.2 2 1 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase zf-CCHC PF00098.23 CCM06901.1 - 1.8 8.7 6.3 1.7 8.9 0.7 2.5 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.7 CCM06901.1 - 9.9 6.3 15.2 21 5.2 15.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon DUF4939 PF16297.5 CCM06904.1 - 0.0014 18.4 0.0 0.0021 17.9 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) RVT_1 PF00078.27 CCM06905.1 - 1.2e-06 28.2 0.1 2.7e-06 27.1 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCM06906.1 - 2.2e-18 66.6 0.0 2.5e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NPA PF16469.5 CCM06908.1 - 0.01 16.4 3.1 0.031 14.9 3.1 1.7 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 TssO PF17561.2 CCM06908.1 - 0.045 13.9 1.7 0.06 13.4 1.7 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO Fib_alpha PF08702.10 CCM06908.1 - 0.14 12.3 2.3 0.17 12.1 2.3 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family RRM_1 PF00076.22 CCM06911.1 - 1.9e-07 30.8 0.0 4.1e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CCM06911.1 - 3.6e-05 23.7 0.0 9.3e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 CCM06911.1 - 0.004 17.1 0.0 0.0069 16.4 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CCM06911.1 - 0.007 16.2 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.22 CCM06912.1 - 4.9e-10 39.1 0.0 8.7e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CCM06912.1 - 2.3e-05 24.3 0.0 4.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CCM06912.1 - 2.9e-05 23.8 0.0 5.9e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 CCM06912.1 - 5.3e-05 23.2 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif EHN PF06441.12 CCM06913.1 - 6.1e-66 219.6 5.3 1.8e-32 111.9 0.0 3.8 4 0 0 4 4 4 2 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CCM06913.1 - 2.6e-28 99.4 0.4 6.5e-13 48.9 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM06913.1 - 8.9e-11 42.8 10.3 2.8e-05 24.9 3.1 3.3 2 1 0 2 2 2 2 Alpha/beta hydrolase family CG-1 PF03859.16 CCM06913.1 - 0.015 15.0 0.3 7.4 6.4 0.0 2.4 2 0 0 2 2 2 0 CG-1 domain DUF5640 PF18692.1 CCM06913.1 - 0.038 14.0 0.1 4.7 7.3 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5640) cobW PF02492.19 CCM06915.1 - 7.8e-31 107.0 0.0 9.9e-31 106.7 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CCM06915.1 - 0.0012 17.9 0.1 0.081 11.9 0.0 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 CCM06915.1 - 0.012 15.6 0.0 0.03 14.4 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 CCM06915.1 - 0.083 13.4 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 CCM06915.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 CCM06915.1 - 0.15 12.4 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CCM06915.1 - 0.17 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 CCM06915.1 - 0.18 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein TIP49 PF06068.13 CCM06915.1 - 0.21 10.8 0.0 0.29 10.3 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain Methyltransf_11 PF08241.12 CCM06916.1 - 1e-17 64.5 0.0 2.7e-17 63.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM06916.1 - 1.3e-17 64.3 0.1 3.5e-17 62.9 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CCM06916.1 - 9.1e-17 61.3 0.0 1.4e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CCM06916.1 - 4.7e-15 55.8 0.0 6.3e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM06916.1 - 6e-13 49.4 0.0 9.7e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CCM06916.1 - 9.2e-11 41.5 0.1 1.1e-08 34.7 0.1 2.9 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CCM06916.1 - 4.4e-09 36.4 0.1 9.8e-09 35.3 0.1 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 CCM06916.1 - 7.1e-08 31.7 0.0 9.4e-08 31.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 CCM06916.1 - 2.4e-07 30.4 0.0 4.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain GCD14 PF08704.10 CCM06916.1 - 0.00024 20.9 0.0 0.00035 20.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 CCM06916.1 - 0.00027 20.7 0.0 0.00042 20.0 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F DREV PF05219.12 CCM06916.1 - 0.0003 20.0 0.0 0.0004 19.6 0.0 1.4 1 1 0 1 1 1 1 DREV methyltransferase ADH_zinc_N PF00107.26 CCM06916.1 - 0.0006 19.8 0.2 0.0014 18.6 0.2 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase PrmA PF06325.13 CCM06916.1 - 0.00075 19.0 0.4 0.0058 16.1 0.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 CCM06916.1 - 0.00094 18.6 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 CCM06916.1 - 0.0017 18.0 0.0 0.0024 17.5 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW DUF938 PF06080.12 CCM06916.1 - 0.014 15.2 0.0 0.042 13.6 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF938) Fibrillarin PF01269.17 CCM06916.1 - 0.028 13.6 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin Methyltransf_32 PF13679.6 CCM06916.1 - 0.031 14.3 0.1 0.031 14.3 0.1 2.3 3 0 0 3 3 3 0 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CCM06916.1 - 0.089 13.8 0.0 0.25 12.4 0.0 1.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase CheR PF01739.18 CCM06916.1 - 0.11 11.9 0.0 0.39 10.2 0.0 1.9 3 0 0 3 3 3 0 CheR methyltransferase, SAM binding domain FtsJ PF01728.19 CCM06916.1 - 0.2 11.8 0.4 1.6 8.8 0.0 2.5 2 1 2 4 4 4 0 FtsJ-like methyltransferase ABC2_membrane_3 PF12698.7 CCM06917.1 - 0.053 12.6 7.7 0.071 12.2 7.7 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4212 PF13937.6 CCM06917.1 - 0.13 12.7 4.5 6.3 7.2 3.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) DUF2207 PF09972.9 CCM06917.1 - 0.41 9.4 2.1 0.56 8.9 2.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Prok-RING_1 PF14446.6 CCM06919.1 - 1 9.3 5.4 2.1 8.4 5.4 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 RVT_1 PF00078.27 CCM06920.1 - 2.3e-27 96.0 0.0 4e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCM06920.1 - 4.5e-09 36.2 0.1 9.6e-09 35.1 0.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase EFP_N PF08207.12 CCM06920.1 - 0.01 15.9 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Exo_endo_phos PF03372.23 CCM06920.1 - 0.014 15.0 0.4 0.029 13.9 0.4 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF4939 PF16297.5 CCM06921.1 - 0.00046 20.0 1.0 0.00058 19.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4939) Zn_ribbon_17 PF17120.5 CCM06923.1 - 0.087 12.5 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type VirB3 PF05101.13 CCM06923.1 - 0.51 10.6 5.9 4.6 7.5 0.9 2.3 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein Pex2_Pex12 PF04757.14 CCM06923.1 - 0.51 9.9 6.3 0.66 9.5 6.3 1.1 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region RVT_1 PF00078.27 CCM06924.1 - 0.0007 19.2 0.0 0.00079 19.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chromo PF00385.24 CCM06925.1 - 1.5e-10 40.8 0.2 4.2e-10 39.4 0.0 1.8 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain SUR7 PF06687.12 CCM06926.1 - 0.011 15.4 0.4 0.019 14.6 0.4 1.3 1 1 0 1 1 1 0 SUR7/PalI family ABC2_membrane_3 PF12698.7 CCM06926.1 - 0.19 10.8 3.3 0.26 10.4 3.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Herpes_UL73 PF03554.13 CCM06926.1 - 0.32 11.0 1.5 0.75 9.8 1.5 1.6 1 0 0 1 1 1 0 UL73 viral envelope glycoprotein VirB3 PF05101.13 CCM06926.1 - 1.1 9.6 5.1 9.9 6.5 1.0 2.2 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein LapA_dom PF06305.11 CCM06926.1 - 8 6.4 7.6 0.66 9.8 0.2 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain WD40 PF00400.32 CCM06928.1 - 7.7e-37 124.7 13.3 1.7e-08 34.9 0.2 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCM06928.1 - 1.4e-07 31.7 3.2 0.39 11.1 0.1 4.3 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain CHAP PF05257.16 CCM06928.1 - 7.7e-06 26.4 1.6 4.8 7.8 0.0 4.3 2 2 2 4 4 4 2 CHAP domain BBS2_Mid PF14783.6 CCM06928.1 - 9.1e-06 25.7 0.6 6.2 6.9 0.0 4.1 3 1 1 4 4 4 3 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 CCM06928.1 - 1.1e-05 24.4 5.3 0.18 10.5 0.1 3.3 1 1 2 3 3 3 3 Nup133 N terminal like Nup160 PF11715.8 CCM06928.1 - 0.00041 19.1 9.3 0.15 10.7 0.1 3.8 2 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 CCM06928.1 - 0.021 14.1 0.0 0.52 9.6 0.0 2.5 2 1 1 3 3 3 0 WD40-like domain Ge1_WD40 PF16529.5 CCM06928.1 - 0.063 12.2 0.1 3.8 6.4 0.0 2.5 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FAM72 PF14976.6 CCM06930.1 - 2.7e-12 47.1 1.4 1.5e-10 41.4 0.9 2.2 2 0 0 2 2 2 2 FAM72 protein Yippee-Mis18 PF03226.14 CCM06930.1 - 0.55 10.5 7.2 5.5 7.2 7.1 2.0 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Metallophos PF00149.28 CCM06931.1 - 3.1e-13 50.7 0.2 4.9e-13 50.0 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase p450 PF00067.22 CCM06932.1 - 3.2e-46 158.0 0.1 6.9e-46 156.9 0.1 1.5 2 0 0 2 2 2 1 Cytochrome P450 SUR7 PF06687.12 CCM06935.1 - 0.014 15.1 4.4 0.024 14.3 4.4 1.4 1 0 0 1 1 1 0 SUR7/PalI family DUF1189 PF06691.11 CCM06935.1 - 0.24 10.9 8.0 0.39 10.2 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) YwiC PF14256.6 CCM06935.1 - 0.61 10.4 9.2 1.3 9.4 9.2 1.6 1 1 0 1 1 1 0 YwiC-like protein Tetraspanin PF00335.20 CCM06935.1 - 1.2 8.7 4.0 1.9 8.2 4.0 1.2 1 0 0 1 1 1 0 Tetraspanin family DoxX_2 PF13564.6 CCM06935.1 - 2.1 8.5 12.6 0.25 11.5 2.2 2.4 1 1 1 2 2 2 0 DoxX-like family PhoR PF11808.8 CCM06935.1 - 5.8 7.4 9.3 16 6.0 0.4 2.5 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR SOG2 PF10428.9 CCM06938.1 - 0.017 14.3 1.6 0.02 14.1 1.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein LapA_dom PF06305.11 CCM06938.1 - 0.094 12.5 0.5 0.094 12.5 0.5 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain PhoR PF11808.8 CCM06938.1 - 0.9 10.0 4.4 11 6.5 0.2 2.3 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR VirB8 PF04335.13 CCM06938.1 - 3.2 7.5 4.5 14 5.5 0.3 2.2 2 0 0 2 2 2 0 VirB8 protein DUF4939 PF16297.5 CCM06941.1 - 0.00088 19.1 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) YabA PF06156.13 CCM06941.1 - 0.02 15.5 2.0 0.026 15.2 0.6 1.9 2 0 0 2 2 2 0 Initiation control protein YabA CENP-H PF05837.12 CCM06941.1 - 0.046 14.1 1.6 0.12 12.8 1.6 1.8 1 0 0 1 1 1 0 Centromere protein H (CENP-H) BBP1_C PF15272.6 CCM06941.1 - 1.1 9.1 6.2 0.25 11.1 2.3 1.8 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal APG6_N PF17675.1 CCM06941.1 - 8.7 6.9 11.8 4 8.0 0.3 2.6 3 0 0 3 3 3 0 Apg6 coiled-coil region KaiB PF07689.12 CCM06946.1 - 0.039 13.7 0.1 0.073 12.8 0.1 1.4 1 0 0 1 1 1 0 KaiB domain DUF4939 PF16297.5 CCM06947.1 - 3e-05 23.8 0.1 3.5e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) DnaG_DnaB_bind PF08278.11 CCM06947.1 - 0.033 14.8 0.5 2.5 8.7 0.1 2.1 1 1 0 2 2 2 0 DNA primase DnaG DnaB-binding gag-asp_proteas PF13975.6 CCM06951.1 - 2.2e-08 34.5 0.0 4.2e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CCM06951.1 - 4.1e-07 30.5 0.0 7.3e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 CCM06951.1 - 0.00036 20.3 0.2 0.00055 19.7 0.2 1.2 1 0 0 1 1 1 1 Aspartyl protease Drf_GBD PF06371.13 CCM06951.1 - 0.013 15.1 0.7 0.022 14.3 0.7 1.3 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain DUF4588 PF15251.6 CCM06953.1 - 0.004 17.0 1.8 0.0093 15.8 1.8 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) HTH_Tnp_Tc5 PF03221.16 CCM06954.1 - 2.8e-10 40.1 0.1 6.4e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF4939 PF16297.5 CCM06955.1 - 0.00036 20.4 0.0 0.0006 19.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) F-box-like PF12937.7 CCM06959.1 - 0.00053 19.8 0.0 0.0014 18.4 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CCM06959.1 - 0.02 14.8 0.5 0.38 10.7 0.1 3.2 2 1 0 2 2 2 0 F-box domain VirB3 PF05101.13 CCM06962.1 - 5 7.4 9.0 1 9.6 0.3 2.2 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein RVT_1 PF00078.27 CCM06964.1 - 0.015 14.8 0.0 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DRMBL PF07522.14 CCM06966.1 - 2.3e-30 105.0 0.1 6.1e-30 103.7 0.0 1.7 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 CCM06966.1 - 5.9e-06 25.9 0.0 1.7e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Peptidase_S10 PF00450.22 CCM06968.1 - 1e-07 31.7 0.0 1.4e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase RIIa PF02197.17 CCM06968.1 - 0.032 13.9 0.1 0.055 13.2 0.1 1.3 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit Peptidase_S10 PF00450.22 CCM06969.1 - 1.3e-45 156.6 2.5 7.1e-45 154.2 2.9 1.9 3 0 0 3 3 3 1 Serine carboxypeptidase Herpes_UL69 PF05459.12 CCM06970.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus transcriptional regulator family ABC2_membrane_3 PF12698.7 CCM06971.1 - 0.89 8.6 6.1 1.3 8.1 6.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein CoA_binding_3 PF13727.6 CCM06971.1 - 1.3 9.0 5.2 9.2 6.2 2.7 2.1 2 0 0 2 2 2 0 CoA-binding domain DHHC PF01529.20 CCM06971.1 - 4.6 7.4 5.5 8.8 6.4 5.3 1.6 1 1 1 2 2 2 0 DHHC palmitoyltransferase LapA_dom PF06305.11 CCM06971.1 - 4.6 7.1 7.7 0.4 10.5 0.3 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RVT_1 PF00078.27 CCM06980.1 - 1.6e-23 83.4 0.1 2.1e-23 83.0 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4939 PF16297.5 CCM06981.1 - 0.019 14.9 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) Pkinase_fungal PF17667.1 CCM06984.1 - 3.9e-16 58.8 0.0 6.8e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase YIF1 PF03878.15 CCM06985.1 - 2.9e-79 265.9 0.0 4e-79 265.5 0.0 1.1 1 0 0 1 1 1 1 YIF1 Ribosomal_L38e PF01781.18 CCM06985.1 - 5e-30 103.4 0.6 7.4e-30 102.9 0.6 1.3 1 0 0 1 1 1 1 Ribosomal L38e protein family Yip1 PF04893.17 CCM06985.1 - 4.6e-06 26.5 0.6 7.1e-06 25.9 0.6 1.2 1 0 0 1 1 1 1 Yip1 domain Phage_holin_2_1 PF04971.12 CCM06985.1 - 0.0088 16.0 1.1 0.019 15.0 1.1 1.5 1 0 0 1 1 1 1 Bacteriophage P21 holin S CMAS PF02353.20 CCM06986.1 - 8.8e-64 215.4 0.0 1.2e-63 215.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CCM06986.1 - 2e-11 44.0 0.0 3.7e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCM06986.1 - 1.2e-09 38.7 0.0 6.1e-09 36.5 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCM06986.1 - 2.1e-09 37.9 0.0 2.6e-08 34.4 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCM06986.1 - 3.5e-06 27.7 0.0 9e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 CCM06986.1 - 0.001 18.6 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 CCM06986.1 - 0.025 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 CCM06986.1 - 0.028 14.2 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CCM06986.1 - 0.033 14.0 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain RCC1 PF00415.18 CCM06989.1 - 4.7e-34 116.8 7.4 9.6e-08 32.5 1.5 6.6 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCM06989.1 - 1.9e-07 30.7 29.8 0.0081 15.9 1.1 6.2 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat Nucleoporin_FG PF13634.6 CCM06990.1 - 0.00013 22.8 6.9 0.00023 21.9 6.9 1.4 1 0 0 1 1 1 1 Nucleoporin FG repeat region HMG_CoA_synt_C PF08540.10 CCM06991.1 - 4.9e-89 298.7 0.1 7e-89 298.1 0.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 CCM06991.1 - 3.7e-84 280.9 0.5 7.4e-84 279.9 0.2 1.7 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III_C PF08541.10 CCM06991.1 - 0.0028 17.8 0.0 0.12 12.6 0.0 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal F-box-like PF12937.7 CCM06992.1 - 2.7e-09 36.7 1.9 5.6e-09 35.7 0.7 2.3 2 0 0 2 2 2 1 F-box-like BTB PF00651.31 CCM06993.1 - 1.8e-11 44.2 1.0 3.6e-07 30.4 0.0 3.1 3 0 0 3 3 3 2 BTB/POZ domain Skp1_POZ PF03931.15 CCM06993.1 - 0.24 11.6 0.4 22 5.3 0.1 2.3 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Carb_kinase PF01256.17 CCM06994.1 - 5.6e-50 170.1 0.0 8.3e-50 169.5 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 CCM06994.1 - 0.0084 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DDE_3 PF13358.6 CCM06997.1 - 1.4e-07 31.4 0.0 2e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease TMEM132D_C PF15706.5 CCM07002.1 - 0.0061 16.3 0.4 1.1 9.1 0.0 2.1 2 0 0 2 2 2 2 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF1218 PF06749.12 CCM07002.1 - 0.11 13.0 6.7 3.1 8.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) DUF2244 PF10003.9 CCM07002.1 - 0.13 12.0 6.7 0.83 9.3 0.5 2.1 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) PhoR PF11808.8 CCM07002.1 - 0.35 11.3 5.8 4.2 7.8 0.2 2.3 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR DUF2182 PF09948.9 CCM07002.1 - 0.42 10.5 4.9 6.7 6.5 0.2 2.1 2 0 0 2 2 2 0 Predicted metal-binding integral membrane protein (DUF2182) 2TM PF13239.6 CCM07002.1 - 0.65 10.4 12.8 0.33 11.3 1.6 2.1 2 0 0 2 2 2 0 2TM domain TraE PF05309.11 CCM07002.1 - 0.65 9.4 5.2 2.4 7.5 0.4 2.0 2 0 0 2 2 2 0 TraE protein Sid-5 PF17204.3 CCM07002.1 - 0.68 10.1 6.6 2.8 8.2 1.2 2.1 2 0 0 2 2 2 0 Sid-5 family Pox_EPC_I2-L1 PF12575.8 CCM07002.1 - 3.3 8.0 12.8 1.7 8.9 1.6 2.3 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DotU PF09850.9 CCM07002.1 - 4.3 7.0 6.9 1 9.0 0.1 2.2 2 0 0 2 2 2 0 Type VI secretion system protein DotU DUF2418 PF10332.9 CCM07002.1 - 5.4 7.6 9.6 5.3 7.6 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) BatA PF07584.11 CCM07002.1 - 9.4 6.7 16.5 8.1 6.9 2.1 2.6 2 1 0 2 2 2 0 Aerotolerance regulator N-terminal DUF4939 PF16297.5 CCM07006.1 - 0.00026 20.8 0.0 0.00052 19.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Retrotrans_gag PF03732.17 CCM07006.1 - 0.21 11.9 0.0 0.35 11.2 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon gag protein DUF4449 PF14613.6 CCM07009.1 - 5.5e-33 114.4 0.1 5.5e-33 114.4 0.1 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF4449) dCache_2 PF08269.11 CCM07009.1 - 0.083 12.1 1.2 0.15 11.2 1.2 1.3 1 0 0 1 1 1 0 Cache domain Abhydrolase_3 PF07859.13 CCM07010.1 - 7e-24 84.9 0.0 9.7e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCM07010.1 - 4.1e-09 35.8 0.0 6.4e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 CCM07010.1 - 0.00026 21.7 0.5 0.00049 20.8 0.1 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family zf-CCHC PF00098.23 CCM07016.1 - 1e-06 28.5 1.5 1.9e-06 27.7 1.5 1.5 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 CCM07016.1 - 0.00013 22.4 0.9 0.00022 21.6 0.9 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_4 PF14392.6 CCM07016.1 - 0.009 15.7 0.4 0.016 14.9 0.4 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 CCM07016.1 - 0.012 15.3 3.7 0.04 13.6 2.6 2.1 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 CCM07016.1 - 0.024 14.5 3.9 0.042 13.7 3.9 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.6 CCM07016.1 - 0.042 13.8 0.8 0.072 13.1 0.8 1.4 1 0 0 1 1 1 0 Zinc knuckle Ndc1_Nup PF09531.10 CCM07016.1 - 0.062 12.0 1.3 0.075 11.7 1.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Chromo PF00385.24 CCM07020.1 - 1.7e-09 37.4 0.3 5e-09 35.9 0.1 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF4939 PF16297.5 CCM07021.1 - 0.00088 19.1 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) PRP3 PF08572.10 CCM07028.1 - 0.0022 17.8 0.1 0.0024 17.7 0.1 1.0 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DCR PF14047.6 CCM07031.1 - 0.1 12.8 0.2 0.23 11.7 0.2 1.5 1 0 0 1 1 1 0 Dppa2/4 conserved region zf-CCHC PF00098.23 CCM07032.1 - 2.6e-05 24.1 3.1 4.7e-05 23.3 3.1 1.4 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 CCM07032.1 - 0.00053 20.4 0.4 0.0013 19.2 0.4 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_2 PF13696.6 CCM07032.1 - 0.0078 16.0 6.8 0.013 15.3 6.8 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 CCM07032.1 - 0.068 12.9 0.8 0.15 11.8 0.8 1.6 1 0 0 1 1 1 0 Zinc knuckle MMR_HSR1 PF01926.23 CCM07034.1 - 6.3e-05 23.0 0.1 9e-05 22.5 0.1 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CCM07034.1 - 0.00082 18.9 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CCM07034.1 - 0.0035 17.3 0.0 0.0047 16.8 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase Roc PF08477.13 CCM07034.1 - 0.01 16.0 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 CCM07034.1 - 0.019 14.4 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 CCM07034.1 - 0.048 14.2 0.1 0.062 13.8 0.1 1.2 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 CCM07034.1 - 0.052 12.7 0.0 0.08 12.1 0.0 1.3 1 1 0 1 1 1 0 NB-ARC domain G-alpha PF00503.20 CCM07034.1 - 0.074 12.2 0.0 0.074 12.2 0.0 1.2 1 1 0 1 1 1 0 G-protein alpha subunit Septin PF00735.18 CCM07034.1 - 0.083 12.2 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 CCM07034.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 CCM07034.1 - 0.11 12.1 0.0 0.21 11.3 0.0 1.3 1 1 0 1 1 1 0 AAA domain ADH_N_2 PF16884.5 CCM07036.1 - 1.1e-18 67.1 0.0 4.4e-18 65.1 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CCM07036.1 - 1.9e-17 63.5 0.4 7.7e-17 61.5 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CCM07036.1 - 6.7e-06 27.2 0.0 5.8e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 CCM07036.1 - 8e-06 25.8 0.1 0.0006 19.7 0.0 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF2855) TrkA_N PF02254.18 CCM07036.1 - 0.0014 18.9 0.0 0.0024 18.1 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain ETX_MTX2 PF03318.13 CCM07037.1 - 8.1e-12 45.4 4.4 1.3e-11 44.8 3.4 1.6 1 1 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 CCM07037.1 - 7.6e-06 25.4 0.6 9.7e-06 25.0 0.6 1.2 1 0 0 1 1 1 1 Aerolysin toxin Fascin PF06268.13 CCM07037.1 - 0.0036 17.5 0.0 0.0089 16.2 0.0 1.6 1 0 0 1 1 1 1 Fascin domain AIG1 PF04548.16 CCM07038.1 - 2.9e-09 36.6 0.2 1.1e-08 34.6 0.1 2.1 1 1 1 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 CCM07038.1 - 8.8e-07 29.0 1.7 1e-05 25.5 0.3 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 CCM07038.1 - 0.00011 21.6 0.2 0.00011 21.6 0.2 2.1 2 0 0 2 2 2 1 Septin AAA_15 PF13175.6 CCM07038.1 - 0.00017 21.5 0.0 0.0018 18.1 0.0 2.7 1 1 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CCM07038.1 - 0.0009 18.7 0.0 0.0023 17.3 0.0 1.7 1 0 0 1 1 1 1 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 CCM07038.1 - 0.0012 18.8 0.2 0.0043 17.0 0.2 1.9 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CCM07038.1 - 0.0012 19.2 0.2 0.0035 17.8 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CCM07038.1 - 0.0032 17.7 1.7 0.015 15.6 0.0 2.8 2 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 CCM07038.1 - 0.0044 17.0 0.1 0.0096 15.9 0.1 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) T2SSE PF00437.20 CCM07038.1 - 0.0047 16.0 1.0 0.011 14.8 0.2 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 CCM07038.1 - 0.0088 16.6 0.1 0.0088 16.6 0.1 2.9 4 1 0 4 4 3 1 ABC transporter UPF0122 PF04297.14 CCM07038.1 - 0.012 15.9 1.1 0.012 15.9 1.1 3.1 2 1 1 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like AAA PF00004.29 CCM07038.1 - 0.019 15.4 0.9 0.071 13.5 0.0 2.5 2 1 1 3 3 2 0 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.27 CCM07038.1 - 0.023 14.3 4.1 0.051 13.1 0.2 2.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Zeta_toxin PF06414.12 CCM07038.1 - 0.024 13.9 0.3 0.11 11.8 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 CCM07038.1 - 0.027 14.2 0.0 0.071 12.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_29 PF13555.6 CCM07038.1 - 0.028 14.2 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 CCM07038.1 - 0.029 14.1 0.8 0.073 12.8 0.1 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CCM07038.1 - 0.075 12.9 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 NACHT domain RasGAP_C PF03836.15 CCM07038.1 - 0.22 11.6 7.7 0.059 13.5 2.5 2.5 2 1 0 2 2 2 0 RasGAP C-terminus ResIII PF04851.15 CCM07038.1 - 0.24 11.4 0.0 0.24 11.4 0.0 2.8 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CCM07038.1 - 0.27 11.5 3.8 0.44 10.9 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCM07038.1 - 0.31 11.6 1.9 0.69 10.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 CCM07038.1 - 0.4 11.2 23.0 8.5e+02 0.3 23.0 3.2 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CCM07038.1 - 0.87 9.1 6.7 0.075 12.5 0.4 2.3 2 1 1 3 3 3 0 P-loop containing dynein motor region Thymidylate_kin PF02223.17 CCM07038.1 - 4.8 6.8 8.0 0.37 10.5 0.1 2.9 4 0 0 4 4 3 0 Thymidylate kinase CM2 PF03021.14 CCM07043.1 - 0.069 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Influenza C virus M2 protein p450 PF00067.22 CCM07044.1 - 4.8e-51 173.9 0.0 5.1e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CCM07045.1 - 6.9e-57 193.2 0.0 7.9e-57 193.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_2 PF00891.18 CCM07046.1 - 9.7e-21 74.0 0.0 4.6e-20 71.8 0.0 1.8 2 0 0 2 2 2 1 O-methyltransferase domain MarR_2 PF12802.7 CCM07046.1 - 0.0002 21.1 0.1 0.0011 18.8 0.0 2.1 2 0 0 2 2 2 1 MarR family RPA_C PF08784.11 CCM07046.1 - 0.0012 19.4 0.0 0.0023 18.5 0.0 1.5 1 0 0 1 1 1 1 Replication protein A C terminal Methyltransf_25 PF13649.6 CCM07046.1 - 0.0053 17.4 0.0 0.031 15.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain DprA_WH PF17782.1 CCM07046.1 - 0.0064 16.6 0.0 0.017 15.2 0.0 1.7 1 0 0 1 1 1 1 DprA winged helix domain MTS PF05175.14 CCM07046.1 - 0.008 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain HTH_IclR PF09339.10 CCM07046.1 - 0.027 14.3 0.0 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_28 PF13518.6 CCM07046.1 - 0.033 14.3 0.0 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain MarR PF01047.22 CCM07046.1 - 0.045 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 MarR family LIP PF03583.14 CCM07046.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Secretory lipase Dimerisation PF08100.11 CCM07046.1 - 0.095 12.7 0.0 0.32 11.1 0.0 2.0 1 0 0 1 1 1 0 Dimerisation domain Methyltransf_16 PF10294.9 CCM07046.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Rrf2 PF02082.20 CCM07046.1 - 0.14 12.6 0.0 1 9.7 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulator TraG-D_C PF12696.7 CCM07050.1 - 0.16 12.0 0.6 2.6 8.1 0.0 2.1 1 1 1 2 2 2 0 TraM recognition site of TraD and TraG Fungal_trans PF04082.18 CCM07053.1 - 8.3e-12 44.7 0.0 1.2e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain cobW PF02492.19 CCM07054.1 - 3.1e-40 137.6 0.0 4.4e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain DnaJ PF00226.31 CCM07054.1 - 3.4e-14 52.7 0.0 8.5e-14 51.4 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain MobB PF03205.14 CCM07054.1 - 0.025 14.5 0.0 0.06 13.3 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 CCM07054.1 - 0.065 13.6 0.0 0.47 10.8 0.0 2.3 1 1 0 1 1 1 0 AAA ATPase domain CobW_C PF07683.14 CCM07054.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain DUF572 PF04502.13 CCM07055.1 - 7.3e-66 223.1 0.5 8.9e-66 222.8 0.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Bestrophin PF01062.21 CCM07055.1 - 0.099 12.0 1.2 0.15 11.4 1.2 1.2 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel Ribosomal_S10 PF00338.22 CCM07056.1 - 5.9e-28 97.0 0.4 7.1e-28 96.7 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Exo_endo_phos PF03372.23 CCM07057.1 - 0.0062 16.1 0.0 0.02 14.4 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Voldacs PF03517.13 CCM07058.1 - 4.7e-26 91.6 0.2 6.8e-26 91.0 0.2 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling SH3_1 PF00018.28 CCM07059.1 - 7.3e-13 47.9 0.2 1.1e-12 47.4 0.2 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CCM07059.1 - 1.2e-10 40.9 0.0 1.9e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CCM07059.1 - 9.6e-10 38.2 0.1 1.4e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Variant SH3 domain RVT_1 PF00078.27 CCM07062.1 - 3e-27 95.6 0.0 4.9e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4035 PF13227.6 CCM07067.1 - 0.17 11.7 0.1 0.22 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4035) Sigma_reg_N PF13800.6 CCM07071.1 - 1.5 9.2 5.0 7.6 6.9 1.8 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF4939 PF16297.5 CCM07072.1 - 0.00054 19.8 0.5 0.00076 19.3 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4939) zf-CCCH PF00642.24 CCM07076.1 - 1.8e-09 37.3 25.3 0.00019 21.3 2.2 4.5 3 1 1 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 CCM07076.1 - 0.62 10.3 13.2 1.9 8.8 3.1 3.3 1 1 2 3 3 3 0 Zinc-finger containing family Cnd2 PF05786.14 CCM07077.1 - 4.7e-178 594.3 7.1 2.5e-177 592.0 7.1 1.8 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 CCM07077.1 - 0.03 14.5 0.0 0.088 13.0 0.0 1.8 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Dermcidin PF15291.6 CCM07077.1 - 0.27 11.8 2.6 1.5 9.4 0.3 2.6 2 0 0 2 2 2 0 Dermcidin, antibiotic peptide EF-hand_7 PF13499.6 CCM07078.1 - 0.17 12.4 1.2 0.63 10.5 1.4 1.9 2 0 0 2 2 2 0 EF-hand domain pair Sugar_tr PF00083.24 CCM07079.1 - 5.2e-126 421.1 24.1 6e-126 420.9 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CCM07079.1 - 2e-16 59.9 43.5 2.2e-16 59.8 39.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_A14 PF05767.12 CCM07079.1 - 0.1 12.7 0.4 0.74 10.0 0.1 2.6 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 Ecl1 PF12855.7 CCM07081.1 - 0.00088 20.5 10.8 0.00088 20.5 10.8 3.3 1 1 2 3 3 3 1 ECL1/2/3 zinc binding proteins RVT_1 PF00078.27 CCM07082.1 - 8.1e-26 90.9 0.0 1.5e-25 90.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCM07084.1 - 0.0003 20.4 0.0 0.11 12.1 0.0 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCM07085.1 - 2e-08 34.2 0.0 3.7e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CCM07085.1 - 0.00073 19.8 0.0 0.0017 18.6 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Nop10p PF04135.12 CCM07085.1 - 0.052 13.6 0.2 0.15 12.1 0.2 1.7 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family NUDIX PF00293.28 CCM07088.1 - 3e-07 30.5 0.0 5.7e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain GST_N PF02798.20 CCM07089.1 - 1.2e-18 67.2 0.1 2.9e-18 66.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CCM07089.1 - 2.3e-14 53.5 0.0 4.1e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CCM07089.1 - 2.3e-13 50.1 0.0 4.1e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CCM07089.1 - 3.6e-13 49.6 0.0 2.2e-12 47.1 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CCM07089.1 - 5e-09 36.2 0.0 1e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CCM07089.1 - 0.00028 20.8 0.0 0.00052 20.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Lyase_8_C PF02884.17 CCM07089.1 - 0.045 14.2 0.0 0.08 13.4 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide lyase family 8, C-terminal beta-sandwich domain GST_C_5 PF16865.5 CCM07089.1 - 0.12 12.9 0.0 11 6.7 0.0 2.2 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain Abhydrolase_1 PF00561.20 CCM07091.1 - 2.4e-13 50.3 0.2 3.2e-13 49.9 0.2 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CCM07091.1 - 1.9e-11 45.0 2.2 1.9e-11 45.0 2.2 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM07091.1 - 7.7e-11 41.7 0.1 1.1e-10 41.3 0.1 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 CCM07091.1 - 0.0014 18.2 0.2 0.04 13.5 0.2 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Lipase_2 PF01674.18 CCM07091.1 - 0.25 10.8 0.0 0.36 10.3 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 2) p450 PF00067.22 CCM07093.1 - 2.7e-28 99.0 0.0 3.3e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Herpes_UL47 PF03362.13 CCM07093.1 - 0.15 10.8 0.2 0.23 10.2 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL47 protein Pex24p PF06398.11 CCM07095.1 - 6.5e-07 28.7 4.0 8.7e-07 28.3 4.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin HSCB_C PF07743.13 CCM07096.1 - 1.5e-15 57.4 3.7 2.5e-15 56.7 2.7 1.8 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 CCM07096.1 - 1e-05 25.5 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain FCD PF07729.12 CCM07096.1 - 0.011 16.2 4.0 0.013 16.0 1.3 2.0 2 0 0 2 2 2 0 FCD domain HA2 PF04408.23 CCM07097.1 - 1.6e-17 63.8 0.0 4e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CCM07097.1 - 3.3e-14 53.2 0.0 1.3e-13 51.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain dsrm PF00035.26 CCM07097.1 - 1.5e-11 44.8 0.0 1.3e-05 25.8 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif DEAD PF00270.29 CCM07097.1 - 9.7e-06 25.5 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 CCM07097.1 - 0.00021 21.6 0.0 0.00054 20.3 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_19 PF13245.6 CCM07097.1 - 0.017 15.5 0.0 0.034 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AGTRAP PF06396.11 CCM07098.1 - 0.01 15.6 0.8 0.025 14.4 0.8 1.7 1 1 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) TAL_FSA PF00923.19 CCM07099.1 - 2.7e-34 118.9 1.3 3.5e-34 118.5 1.3 1.2 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Flot PF15975.5 CCM07099.1 - 0.028 14.6 2.0 1.8 8.7 0.8 2.6 2 0 0 2 2 2 0 Flotillin DNA_pol_B PF00136.21 CCM07100.1 - 4.4e-103 345.4 0.0 5.4e-103 345.2 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.6 CCM07100.1 - 7.6e-15 55.1 2.6 1.6e-14 54.1 2.6 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo1 PF03104.19 CCM07100.1 - 8.1e-13 48.2 0.0 1.4e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 CCM07100.1 - 0.06 12.2 0.0 0.097 11.5 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral SDA1 PF05285.12 CCM07106.1 - 0.97 8.8 16.0 1.1 8.6 16.0 1.0 1 0 0 1 1 1 0 SDA1 DUF4939 PF16297.5 CCM07110.1 - 0.00036 20.4 0.0 0.00066 19.5 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4939) RhaA PF06134.11 CCM07110.1 - 0.018 14.2 0.0 0.019 14.1 0.0 1.1 1 0 0 1 1 1 0 L-rhamnose isomerase (RhaA) RVT_1 PF00078.27 CCM07112.1 - 1e-17 64.4 0.1 1.3e-17 64.0 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Chromo PF00385.24 CCM07113.1 - 2.5e-06 27.3 1.2 4.2e-06 26.6 0.0 2.0 3 0 0 3 3 3 1 Chromo (CHRromatin Organisation MOdifier) domain Virulence_fact PF13769.6 CCM07116.1 - 0.028 14.6 1.4 6.5 7.1 0.0 2.2 1 1 1 2 2 2 0 Virulence factor Ribosomal_S13_N PF08069.12 CCM07117.1 - 2.9 8.0 6.2 2.1 8.5 0.1 2.7 3 0 0 3 3 3 0 Ribosomal S13/S15 N-terminal domain RVT_1 PF00078.27 CCM07119.1 - 5e-13 49.1 0.0 1.8e-09 37.5 0.0 2.3 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 CCM07120.1 - 1.3e-20 73.2 1.7 3.9e-20 71.7 0.2 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CCM07120.1 - 0.0087 16.3 0.2 0.021 15.0 0.2 1.7 1 0 0 1 1 1 1 H2C2 zinc finger IL28A PF15177.6 CCM07120.1 - 0.074 12.9 0.2 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Interleukin-28A SPT_ssu-like PF11779.8 CCM07121.1 - 4.3 7.0 9.7 6.2 6.5 0.2 2.4 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like fn3_6 PF17766.1 CCM07122.1 - 0.15 12.3 0.0 0.19 11.9 0.0 1.1 1 0 0 1 1 1 0 Fibronectin type-III domain ATG7_N PF16420.5 CCM07128.1 - 2.5e-92 309.7 0.0 3.8e-92 309.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 CCM07128.1 - 6.5e-46 156.7 0.0 1.4e-45 155.6 0.0 1.5 2 0 0 2 2 2 1 ThiF family Shikimate_DH PF01488.20 CCM07128.1 - 0.18 11.9 0.0 0.71 9.9 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Chromo PF00385.24 CCM07132.1 - 1e-08 34.9 1.1 8e-08 32.1 0.0 2.7 3 0 0 3 3 3 1 Chromo (CHRromatin Organisation MOdifier) domain rve PF00665.26 CCM07132.1 - 0.0043 17.2 0.0 0.0092 16.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain eIF3g PF12353.8 CCM07133.1 - 0.0022 18.4 2.0 0.0052 17.2 2.0 1.7 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.23 CCM07133.1 - 0.056 13.5 1.1 0.056 13.5 1.1 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 CCM07133.1 - 0.12 12.1 3.1 0.53 10.0 2.8 2.1 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Ndc1_Nup PF09531.10 CCM07133.1 - 0.19 10.4 4.9 0.26 9.9 4.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Wx5_PLAF3D7 PF09688.10 CCM07133.1 - 0.24 11.4 1.0 0.3 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) Cpn10 PF00166.21 CCM07136.1 - 7.7e-26 90.0 0.0 1.6e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit zf-MYND PF01753.18 CCM07136.1 - 9.8e-08 32.0 12.8 1.7e-07 31.2 12.8 1.4 1 0 0 1 1 1 1 MYND finger Pho88 PF10032.9 CCM07137.1 - 1e-74 249.7 0.8 1.2e-74 249.6 0.8 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) DUF4939 PF16297.5 CCM07139.1 - 0.00027 20.8 0.0 0.00047 20.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Phi-29_GP3 PF05435.11 CCM07139.1 - 0.05 13.1 0.1 0.067 12.7 0.1 1.3 1 0 0 1 1 1 0 Phi-29 DNA terminal protein GP3 Retrotrans_gag PF03732.17 CCM07139.1 - 0.079 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Retrotransposon gag protein AMNp_N PF10423.9 CCM07140.1 - 0.0094 15.6 1.2 3.4 7.3 0.1 2.4 2 0 0 2 2 2 2 Bacterial AMP nucleoside phosphorylase N-terminus Gmad1 PF10647.9 CCM07140.1 - 0.89 9.3 5.2 8.3 6.1 0.0 3.2 4 0 0 4 4 4 0 Lipoprotein LpqB beta-propeller domain Ibs_toxin PF13956.6 CCM07142.1 - 0.094 12.7 2.3 0.094 12.7 2.3 1.6 2 0 0 2 2 2 0 Toxin Ibs, type I toxin-antitoxin system DUF4064 PF13273.6 CCM07153.1 - 0.0054 17.0 0.3 0.011 16.0 0.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF4064) VirB3 PF05101.13 CCM07153.1 - 0.008 16.4 4.7 0.39 11.0 2.3 2.1 2 0 0 2 2 2 2 Type IV secretory pathway, VirB3-like protein SUR7 PF06687.12 CCM07153.1 - 0.01 15.5 3.5 0.013 15.1 3.5 1.1 1 0 0 1 1 1 0 SUR7/PalI family DUF2207 PF09972.9 CCM07153.1 - 0.18 10.5 0.9 0.23 10.2 0.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PhoR PF11808.8 CCM07153.1 - 0.97 9.9 10.5 2.4 8.6 3.0 2.1 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR LapA_dom PF06305.11 CCM07153.1 - 1.9 8.3 7.3 2 8.3 0.3 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RVT_1 PF00078.27 CCM07154.1 - 4.1e-05 23.2 0.2 9.5e-05 22.0 0.0 1.7 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4939 PF16297.5 CCM07154.1 - 0.00024 20.9 0.0 0.00051 19.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) RE_ApaLI PF09499.10 CCM07155.1 - 0.062 13.0 0.0 0.078 12.7 0.0 1.1 1 0 0 1 1 1 0 ApaLI-like restriction endonuclease MPC PF03650.13 CCM07158.1 - 0.02 15.0 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial pyruvate carriers FA_desaturase PF00487.24 CCM07159.1 - 2.5e-13 50.5 35.1 3.1e-12 46.9 35.1 2.3 1 1 1 2 2 2 1 Fatty acid desaturase DUF3474 PF11960.8 CCM07159.1 - 4.6e-06 26.9 0.0 7.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) RVT_1 PF00078.27 CCM07168.1 - 3e-05 23.6 0.0 4.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SeqA_N PF17206.3 CCM07169.1 - 0.25 10.7 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 SeqA protein N-terminal domain ADH_N PF08240.12 CCM07171.1 - 5e-11 42.4 0.0 6.8e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Fe-ADH PF00465.19 CCM07177.1 - 2.1e-55 188.0 1.3 2.5e-55 187.8 1.3 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CCM07177.1 - 2.3e-30 106.1 0.2 3e-30 105.8 0.2 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 CCM07177.1 - 0.0018 17.5 1.1 0.039 13.1 1.1 2.6 1 1 0 1 1 1 1 3-dehydroquinate synthase Pkinase PF00069.25 CCM07178.1 - 3.8e-61 206.8 0.0 2.5e-60 204.1 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCM07178.1 - 9.6e-28 97.2 0.0 6.4e-15 55.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 CCM07178.1 - 4.8e-05 23.1 0.1 0.25 11.0 0.0 3.3 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 PX PF00787.24 CCM07178.1 - 0.0009 19.2 0.0 0.0065 16.4 0.0 2.3 1 1 0 1 1 1 1 PX domain Pkinase_C PF00433.24 CCM07178.1 - 0.0015 19.2 7.2 0.0015 19.2 7.2 3.9 3 1 0 3 3 3 1 Protein kinase C terminal domain Kdo PF06293.14 CCM07178.1 - 0.0045 16.4 0.0 0.0094 15.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCM07178.1 - 0.015 15.2 0.4 4.1 7.2 0.0 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 CCM07178.1 - 0.024 14.0 0.0 2.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 CCM07178.1 - 0.024 13.4 0.0 0.13 11.0 0.0 2.3 1 1 0 1 1 1 0 Fungal protein kinase VASt PF16016.5 CCM07179.1 - 1.9e-38 132.3 0.1 3.8e-38 131.3 0.1 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 CCM07179.1 - 4.7e-22 78.0 0.0 8.2e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Asp PF00026.23 CCM07181.1 - 4.7e-45 154.4 7.2 1.3e-43 149.7 7.2 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CCM07181.1 - 3.8e-07 30.5 3.0 6.2e-05 23.3 0.1 3.1 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CCM07181.1 - 0.063 13.9 2.8 0.3 11.7 0.2 2.8 3 0 0 3 3 3 0 Aspartyl protease TAXi_C PF14541.6 CCM07181.1 - 0.14 11.9 0.0 0.44 10.3 0.0 1.8 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Methyltransf_2 PF00891.18 CCM07183.1 - 4.6e-08 32.6 0.0 0.0092 15.3 0.0 3.2 2 1 0 3 3 3 3 O-methyltransferase domain Auxin_BP PF02041.16 CCM07185.1 - 0.039 13.6 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 Auxin binding protein Fic_N PF13784.6 CCM07187.1 - 0.12 12.5 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 Fic/DOC family N-terminal p450 PF00067.22 CCM07188.1 - 1.2e-17 63.8 0.0 1.5e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DBR1 PF05011.13 CCM07188.1 - 0.066 13.6 0.1 0.17 12.3 0.0 1.7 1 1 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain p450 PF00067.22 CCM07189.1 - 5.3e-48 163.9 0.0 2.1e-25 89.4 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 p450 PF00067.22 CCM07190.1 - 1.7e-69 234.7 0.0 2.9e-69 234.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 PMP1_2 PF08114.11 CCM07190.1 - 0.027 14.2 0.1 0.074 12.8 0.1 1.7 1 0 0 1 1 1 0 ATPase proteolipid family p450 PF00067.22 CCM07191.1 - 7.7e-78 262.3 0.0 1.7e-77 261.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 G-alpha PF00503.20 CCM07192.1 - 2.9e-115 385.2 1.9 3.4e-115 385.0 1.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CCM07192.1 - 1.6e-14 53.8 0.1 1.1e-08 34.7 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CCM07192.1 - 0.00097 18.6 0.1 0.54 9.6 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CCM07192.1 - 0.027 14.7 0.1 0.83 9.9 0.1 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CCM07192.1 - 0.087 12.6 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Chromo PF00385.24 CCM07196.1 - 3.4e-08 33.3 1.8 3.7e-08 33.2 0.8 1.6 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain dUTPase PF00692.19 CCM07196.1 - 0.012 15.4 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 dUTPase RsmF_methylt_CI PF17126.5 CCM07197.1 - 0.039 14.0 0.0 0.053 13.6 0.0 1.4 1 1 0 1 1 1 0 RsmF rRNA methyltransferase first C-terminal domain RHH_8 PF17723.1 CCM07197.1 - 0.081 13.1 0.0 0.096 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribbon-Helix-Helix transcriptional regulator family DUF4939 PF16297.5 CCM07201.1 - 0.00019 21.3 0.0 0.00038 20.3 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) 2TM PF13239.6 CCM07204.1 - 0.22 11.9 2.2 0.33 11.3 2.2 1.2 1 0 0 1 1 1 0 2TM domain Chromo PF00385.24 CCM07205.1 - 1.7e-10 40.7 0.0 4.3e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DNA_pol3_delta PF06144.13 CCM07205.1 - 0.038 13.8 0.1 0.056 13.2 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit DUF4939 PF16297.5 CCM07206.1 - 9.4e-05 22.3 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) PNMA PF14893.6 CCM07206.1 - 0.013 14.9 0.6 0.018 14.5 0.6 1.1 1 0 0 1 1 1 0 PNMA Retrotrans_gag PF03732.17 CCM07206.1 - 0.027 14.7 2.0 0.05 13.9 0.1 2.3 1 1 1 2 2 2 0 Retrotransposon gag protein Bacillus_HBL PF05791.11 CCM07206.1 - 0.04 13.7 0.1 0.056 13.3 0.1 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Wx5_PLAF3D7 PF09688.10 CCM07206.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) Acetyltransf_9 PF13527.7 CCM07206.1 - 0.11 12.6 0.6 0.66 10.1 0.2 2.1 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain DUF3328 PF11807.8 CCM07211.1 - 0.029 14.1 0.8 0.042 13.6 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Tetraspanin PF00335.20 CCM07211.1 - 0.075 12.7 0.0 0.075 12.7 0.0 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF2393 PF09624.10 CCM07212.1 - 0.1 12.6 1.0 0.13 12.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) DUF4939 PF16297.5 CCM07215.1 - 0.00024 20.9 0.0 0.00041 20.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) TMEM156 PF15106.6 CCM07221.1 - 0.32 10.4 1.7 0.3 10.5 1.7 1.0 1 0 0 1 1 1 0 TMEM156 protein family DUF4501 PF14946.6 CCM07221.1 - 0.57 10.2 2.4 0.53 10.4 2.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) 2OG-FeII_Oxy_2 PF13532.6 CCM07222.1 - 9.7e-37 127.1 0.0 1.9e-34 119.6 0.0 2.2 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily ATP12 PF07542.11 CCM07223.1 - 4.5e-42 143.2 1.1 4.5e-42 143.2 0.1 1.5 2 0 0 2 2 2 1 ATP12 chaperone protein RsfS PF02410.15 CCM07223.1 - 0.0091 16.4 0.0 0.024 15.1 0.0 1.7 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation SHR3_chaperone PF08229.11 CCM07224.1 - 2.6e-38 130.9 0.0 3.6e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 ER membrane protein SH3 RolB_RolC PF02027.17 CCM07224.1 - 0.15 11.7 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 RolB/RolC glucosidase family DUF4094 PF13334.6 CCM07224.1 - 0.22 12.0 0.1 0.82 10.1 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) RVT_1 PF00078.27 CCM07227.1 - 4.5e-06 26.3 0.0 7.6e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCM07230.1 - 5.6e-11 42.4 0.0 1.1e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCM07230.1 - 2.9e-07 30.2 0.0 4.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CCM07230.1 - 0.031 14.6 0.0 0.083 13.2 0.0 1.8 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CCM07233.1 - 3.8e-06 26.6 0.0 6.3e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 CCM07233.1 - 0.0095 16.0 0.1 0.016 15.2 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase ADH_N PF08240.12 CCM07239.1 - 1.3e-21 76.5 0.6 2.5e-21 75.6 0.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CCM07239.1 - 6.5e-15 55.3 0.1 1.3e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Abhydrolase_6 PF12697.7 CCM07239.1 - 1.3e-09 39.0 6.5 1.3e-09 39.0 6.5 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CCM07239.1 - 5.2e-08 32.5 0.1 0.0025 17.1 0.1 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 CCM07239.1 - 5.5e-05 23.2 0.0 0.00016 21.7 0.0 1.7 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 CCM07239.1 - 9.8e-05 22.1 0.1 0.024 14.3 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold AlaDh_PNT_C PF01262.21 CCM07239.1 - 0.0043 16.4 0.6 0.0075 15.6 0.6 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CCM07239.1 - 0.062 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF374 PF04028.13 CCM07239.1 - 0.13 11.9 0.1 0.28 10.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF374) ELFV_dehydrog PF00208.21 CCM07239.1 - 0.14 11.8 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_10 PF13460.6 CCM07239.1 - 0.19 11.6 0.5 1.3 8.8 0.1 2.0 2 0 0 2 2 2 0 NAD(P)H-binding SpoIIIAC PF06686.11 CCM07239.1 - 0.24 11.6 0.7 3.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family AAA_22 PF13401.6 CCM07240.1 - 0.0042 17.4 0.0 4.5 7.5 0.0 3.4 3 0 0 3 3 3 3 AAA domain RVT_1 PF00078.27 CCM07244.1 - 1.5e-23 83.5 0.2 3.9e-20 72.3 0.1 2.1 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) AMP-binding PF00501.28 CCM07254.1 - 1e-33 116.6 0.0 1.3e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CCM07254.1 - 0.00026 21.9 0.1 0.00058 20.8 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Tri3 PF07428.11 CCM07255.1 - 0.011 14.7 0.2 0.64 8.9 0.0 2.8 3 0 0 3 3 3 0 15-O-acetyltransferase Tri3 Sybindin PF04099.12 CCM07256.1 - 0.08 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Sybindin-like family Abhydrolase_3 PF07859.13 CCM07257.1 - 9.9e-23 81.1 0.0 1.4e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CCM07257.1 - 4e-07 29.2 0.0 6.6e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase DUF2974 PF11187.8 CCM07257.1 - 0.05 13.2 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Peptidase_S9 PF00326.21 CCM07257.1 - 0.09 12.2 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family RVT_1 PF00078.27 CCM07259.1 - 8.6e-23 81.0 0.2 1e-22 80.8 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_7 PF12775.7 CCM07259.1 - 0.12 11.8 0.2 0.2 11.2 0.1 1.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Yip1 PF04893.17 CCM07260.1 - 0.0051 16.5 7.3 0.0063 16.3 7.3 1.1 1 0 0 1 1 1 1 Yip1 domain Neurensin PF14927.6 CCM07260.1 - 0.24 11.1 4.1 0.3 10.8 4.1 1.1 1 0 0 1 1 1 0 Neurensin Choline_transpo PF04515.12 CCM07260.1 - 0.33 10.1 11.4 0.72 9.0 11.4 1.6 1 1 0 1 1 1 0 Plasma-membrane choline transporter p450 PF00067.22 CCM07264.1 - 3e-32 112.0 0.0 3.5e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SUR7 PF06687.12 CCM07268.1 - 0.13 11.9 6.5 0.15 11.7 6.5 1.1 1 0 0 1 1 1 0 SUR7/PalI family # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Fibroporia_radiculosa-ASM31352v1/GCA_000313525.1_ASM31352v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Fibroporia_radiculosa-ASM31352v1/GCA_000313525.1_ASM31352v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Fibroporia_radiculosa-ASM31352v1/GCA_000313525.1_ASM31352v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Fibroporia_radiculosa-ASM31352v1/GCA_000313525.1_ASM31352v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 20:01:46 2019 # [ok]