# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Asp PF00026.23 AMD18500.1 - 2.6e-69 234.1 0.0 3.1e-69 233.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD18500.1 - 2.5e-07 31.1 0.3 9.8e-07 29.2 0.3 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 AMD18500.1 - 0.065 13.8 0.0 5.2 7.7 0.0 3.3 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease MRF_C2 PF13888.6 AMD18500.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Myelin gene regulatory factor C-terminal domain 2 Aldo_ket_red PF00248.21 AMD18501.1 - 4.2e-42 144.4 0.0 2.7e-40 138.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family FBPase PF00316.20 AMD18502.1 - 1.8e-81 272.1 0.7 2.6e-81 271.6 0.7 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Acyltransferase PF01553.21 AMD18503.1 - 6.5e-33 113.2 0.0 1.2e-32 112.3 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase TMEM72 PF16054.5 AMD18503.1 - 0.11 12.1 1.1 0.21 11.3 1.1 1.3 1 0 0 1 1 1 0 Transmembrane protein family 72 LapA_dom PF06305.11 AMD18503.1 - 0.16 11.8 1.4 0.19 11.5 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain PSY3 PF16836.5 AMD18504.1 - 1.9e-58 197.6 0.0 2.1e-58 197.4 0.0 1.0 1 0 0 1 1 1 1 Shu complex component Psy3, DNA-binding description La PF05383.17 AMD18505.1 - 9.8e-22 76.8 0.1 2.2e-21 75.6 0.1 1.7 1 0 0 1 1 1 1 La domain BRAP2 PF07576.12 AMD18505.1 - 0.099 12.9 0.4 0.22 11.8 0.2 1.7 1 1 0 1 1 1 0 BRCA1-associated protein 2 KRE9 PF05390.11 AMD18506.1 - 1.9e-44 150.6 3.6 1.9e-44 150.6 3.6 1.9 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 AMD18506.1 - 3.3e-14 53.4 0.1 8.6e-14 52.1 0.0 1.7 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Big_7 PF17957.1 AMD18506.1 - 0.071 13.9 1.2 0.11 13.3 0.1 2.1 2 1 0 2 2 2 0 Bacterial Ig domain NTP_transferase PF00483.23 AMD18507.1 - 2.4e-53 181.3 0.0 3e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 AMD18507.1 - 1.7e-10 41.5 0.0 2.1e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 AMD18507.1 - 4.3e-09 35.8 5.9 1.7e-06 27.5 1.2 3.4 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AMD18507.1 - 0.0025 17.5 5.0 0.11 12.3 1.2 3.2 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 AMD18507.1 - 0.0033 16.4 0.2 0.012 14.6 0.1 1.8 2 0 0 2 2 2 1 L-fucokinase DUF4954 PF16314.5 AMD18507.1 - 0.012 13.8 0.3 0.017 13.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Ank_4 PF13637.6 AMD18508.1 - 1.8e-13 50.7 0.0 2.4e-05 24.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AMD18508.1 - 4e-11 43.3 0.0 0.00066 20.2 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AMD18508.1 - 2.7e-09 37.1 0.1 0.0029 17.9 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD18508.1 - 2.1e-07 30.7 0.1 0.1 13.2 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 AMD18508.1 - 5.1e-07 29.9 0.1 0.049 14.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat KilA-N PF04383.13 AMD18508.1 - 1.3e-06 28.3 3.3 2.6e-06 27.2 0.2 2.9 2 1 0 2 2 2 1 KilA-N domain RBR PF17208.3 AMD18508.1 - 0.43 11.3 4.5 1.3 9.8 4.5 1.8 1 0 0 1 1 1 0 RNA binding Region Y_phosphatase3 PF13350.6 AMD18509.1 - 1.3e-54 185.6 0.0 1.9e-54 185.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Hydrolase_4 PF12146.8 AMD18509.1 - 8.9e-07 28.4 0.0 2.2e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AMD18509.1 - 0.00018 21.3 0.0 0.053 13.1 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AMD18509.1 - 0.0055 17.3 0.0 0.02 15.5 0.0 1.7 1 1 0 2 2 2 1 Alpha/beta hydrolase family Y_phosphatase2 PF03162.13 AMD18509.1 - 0.0091 15.6 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Coat_F PF07875.12 AMD18509.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Coat F domain Y_phosphatase PF00102.27 AMD18509.1 - 0.088 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Sugar_tr PF00083.24 AMD18510.1 - 2.6e-123 412.2 33.0 3e-123 412.0 33.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD18510.1 - 3.1e-20 72.4 39.6 3.6e-18 65.6 27.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MutS_V PF00488.21 AMD18511.1 - 1.7e-84 282.6 0.8 3.3e-84 281.6 0.8 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AMD18511.1 - 2.4e-33 116.0 1.2 2.4e-33 116.0 1.2 2.4 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 AMD18511.1 - 3.1e-18 65.9 3.6 3.8e-18 65.6 1.2 2.6 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 AMD18511.1 - 5.5e-18 65.6 0.1 5.5e-18 65.6 0.1 2.8 4 0 0 4 4 4 1 MutS domain II MutS_I PF01624.20 AMD18511.1 - 7.9e-10 39.0 0.1 2.6e-09 37.3 0.0 1.9 2 0 0 2 2 2 1 MutS domain I DUF3256 PF11644.8 AMD18511.1 - 0.17 11.3 1.7 0.44 10.0 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3256) DUF1079 PF06435.11 AMD18511.1 - 1 9.6 3.3 5.6 7.3 1.1 2.9 2 0 0 2 2 2 0 Repeat of unknown function (DUF1079) Spc7 PF08317.11 AMD18512.1 - 0.0035 16.3 27.2 0.0035 16.3 27.2 4.1 3 1 3 6 6 6 1 Spc7 kinetochore protein GPHR_N PF12537.8 AMD18512.1 - 3.3 7.8 5.2 4.1 7.6 0.7 3.2 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal Baculo_PEP_C PF04513.12 AMD18512.1 - 10 6.2 9.2 1.2 9.2 2.6 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus tRNA_m1G_MT PF01746.21 AMD18513.1 - 6.2e-33 114.2 1.1 7.4e-33 113.9 0.1 1.6 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase VSG_B PF13206.6 AMD18513.1 - 0.0007 19.0 4.1 0.0007 19.0 4.1 1.5 2 0 0 2 2 2 1 Trypanosomal VSG domain Rep_fac_C PF08542.11 AMD18514.1 - 2e-20 73.0 0.1 6.4e-20 71.4 0.0 1.9 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 AMD18514.1 - 7.1e-13 49.1 0.0 2.8e-12 47.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AMD18514.1 - 2.4e-12 46.9 0.0 1.2e-09 38.1 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA_14 PF13173.6 AMD18514.1 - 6.8e-07 29.4 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AMD18514.1 - 1.5e-06 28.7 0.0 0.00013 22.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AMD18514.1 - 9.6e-06 25.9 0.1 0.06 13.6 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_3 PF07726.11 AMD18514.1 - 2.4e-05 24.2 0.0 4.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AMD18514.1 - 6.3e-05 23.0 0.0 0.00015 21.8 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 AMD18514.1 - 9.5e-05 22.2 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 AMD18514.1 - 0.00019 21.2 0.0 0.00048 19.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 AMD18514.1 - 0.00034 20.1 0.0 0.003 17.0 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 AMD18514.1 - 0.003 17.8 0.0 0.0086 16.4 0.0 1.8 2 0 0 2 2 1 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 AMD18514.1 - 0.0039 17.0 0.2 0.0065 16.3 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit TniB PF05621.11 AMD18514.1 - 0.008 15.6 0.0 3.8 6.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial TniB protein AAA_19 PF13245.6 AMD18514.1 - 0.011 16.1 0.1 0.04 14.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 AMD18514.1 - 0.017 14.1 0.0 0.077 12.0 0.0 2.0 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 AMD18514.1 - 0.04 13.8 0.1 0.2 11.6 0.0 2.0 1 1 1 2 2 2 0 NTPase AAA_30 PF13604.6 AMD18514.1 - 0.068 12.9 0.0 0.23 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 AMD18514.1 - 0.08 12.7 0.1 0.47 10.2 0.0 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_11 PF13086.6 AMD18514.1 - 0.092 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AMD18514.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 AMD18514.1 - 0.14 12.1 0.2 0.75 9.7 0.1 2.1 2 1 0 2 2 1 0 NACHT domain Vps52 PF04129.12 AMD18515.1 - 2.4e-134 448.9 19.0 3.2e-134 448.5 19.0 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family DUF5482 PF17579.2 AMD18515.1 - 0.0061 16.4 0.2 0.017 15.0 0.2 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5482) Mer2 PF09074.10 AMD18515.1 - 0.093 12.5 3.5 0.25 11.1 3.0 2.0 1 1 0 1 1 1 0 Mer2 UvrD-helicase PF00580.21 AMD18516.1 - 4.5e-27 95.4 0.7 1.3e-16 61.1 0.3 2.7 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 AMD18516.1 - 1.4e-18 67.6 0.0 8.5e-18 65.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain UvrD_C PF13361.6 AMD18516.1 - 6e-13 48.9 1.6 6e-13 48.9 1.6 3.2 2 2 1 3 3 3 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 AMD18516.1 - 2.2e-05 24.2 0.0 4.1e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 AMD18516.1 - 0.0013 18.5 0.4 0.28 10.9 0.0 3.6 3 2 1 4 4 4 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 AMD18516.1 - 0.0015 18.3 0.0 0.0061 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AMD18516.1 - 0.0018 18.6 1.2 0.24 11.6 0.4 3.7 3 1 0 3 3 3 1 AAA domain T2SSE PF00437.20 AMD18516.1 - 0.013 14.6 0.1 0.029 13.4 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 AMD18516.1 - 0.051 12.8 3.9 0.075 12.3 1.6 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 AMD18516.1 - 0.069 12.9 0.8 0.2 11.4 0.0 2.2 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 AMD18516.1 - 0.071 12.8 5.6 25 4.5 5.3 3.3 2 2 0 2 2 2 0 AAA domain Helicase_RecD PF05127.14 AMD18516.1 - 0.082 12.8 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 Helicase DUF2972 PF11186.8 AMD18516.1 - 1.4 8.8 7.7 0.47 10.3 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2972) YL1 PF05764.13 AMD18517.1 - 1.1e-45 156.6 33.6 1.1e-45 156.6 33.6 2.5 2 1 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 AMD18517.1 - 3e-10 39.7 0.1 4.6e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Methyltransf_23 PF13489.6 AMD18518.1 - 2.7e-22 79.4 0.0 3.7e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD18518.1 - 7.4e-14 52.2 0.0 1.5e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD18518.1 - 4.6e-12 46.5 0.0 2.2e-11 44.4 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD18518.1 - 6.4e-12 46.0 0.0 1.1e-11 45.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD18518.1 - 6.1e-11 42.3 0.0 1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 AMD18518.1 - 1.6e-05 24.6 0.0 2.4e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) CMAS PF02353.20 AMD18518.1 - 6.4e-05 22.4 0.0 9.3e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 AMD18518.1 - 0.0006 19.2 0.0 0.00075 18.9 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 AMD18518.1 - 0.00066 19.2 0.0 0.00096 18.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 AMD18518.1 - 0.0035 16.9 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 AMD18518.1 - 0.0069 16.0 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 AMD18518.1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Spermine_synth PF01564.17 AMD18518.1 - 0.015 14.7 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Methyltransf_18 PF12847.7 AMD18518.1 - 0.018 15.0 0.1 0.029 14.3 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 AMD18518.1 - 0.081 12.0 0.0 0.2 10.7 0.0 1.8 2 0 0 2 2 2 0 DREV methyltransferase Snf7 PF03357.21 AMD18519.1 - 2.9e-40 137.7 20.8 3.5e-40 137.4 20.8 1.0 1 0 0 1 1 1 1 Snf7 Prefoldin PF02996.17 AMD18519.1 - 0.012 15.5 0.4 0.012 15.5 0.4 3.5 1 1 3 4 4 4 0 Prefoldin subunit 2OG-FeII_Oxy_2 PF13532.6 AMD18519.1 - 0.082 13.1 0.9 0.13 12.5 0.9 1.2 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Fib_alpha PF08702.10 AMD18519.1 - 0.47 10.6 18.9 2.3 8.4 11.0 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Not3 PF04065.15 AMD18519.1 - 0.48 9.8 16.7 3.1 7.2 16.7 1.9 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Fmp27_WPPW PF10359.9 AMD18519.1 - 0.5 9.2 13.4 1.7 7.4 13.4 1.8 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF1664 PF07889.12 AMD18519.1 - 0.5 10.4 17.3 0.22 11.6 4.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Peptidase_S46 PF10459.9 AMD18519.1 - 0.86 8.2 11.2 1 7.9 11.2 1.0 1 0 0 1 1 1 0 Peptidase S46 Spc7 PF08317.11 AMD18519.1 - 1.5 7.7 22.0 1 8.2 12.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 AMD18519.1 - 1.5 8.3 13.9 2.1 7.8 13.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prefoldin_2 PF01920.20 AMD18519.1 - 1.8 8.6 21.2 0.14 12.1 0.5 3.2 1 1 1 3 3 3 0 Prefoldin subunit Bcr-Abl_Oligo PF09036.10 AMD18519.1 - 2.1 8.4 5.3 12 6.0 0.1 2.9 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Nup88 PF10168.9 AMD18519.1 - 2.2 6.0 17.9 0.9 7.3 1.4 2.0 1 1 1 2 2 2 0 Nuclear pore component DUF4988 PF16378.5 AMD18519.1 - 2.8 7.6 9.2 2.3e+02 1.4 9.5 2.8 1 1 0 1 1 1 0 Domain of unknown function COG2 PF06148.11 AMD18519.1 - 3.4 7.7 12.5 11 6.1 6.7 3.0 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Sec2p PF06428.11 AMD18519.1 - 3.7 7.6 26.7 0.36 10.8 2.0 3.4 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p FliJ PF02050.16 AMD18519.1 - 4.4 7.5 20.7 1.1 9.4 8.5 2.6 1 1 1 2 2 2 0 Flagellar FliJ protein Seryl_tRNA_N PF02403.22 AMD18519.1 - 5.8 7.2 20.3 5.4 7.3 1.3 3.2 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Cep57_MT_bd PF06657.13 AMD18519.1 - 5.9 7.4 15.2 0.6 10.6 4.5 2.8 1 1 3 4 4 4 0 Centrosome microtubule-binding domain of Cep57 tRNA-synt_1b PF00579.25 AMD18520.1 - 3.2e-17 62.8 0.0 7.1e-12 45.2 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) DHBP_synthase PF00926.19 AMD18521.1 - 6.8e-78 260.6 0.0 7.7e-78 260.4 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase K_channel_TID PF07941.11 AMD18522.1 - 7.8 7.0 11.3 0.32 11.5 3.0 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain SecY PF00344.20 AMD18523.1 - 2.1e-63 214.4 9.0 2.6e-63 214.1 9.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AMD18523.1 - 2.4e-17 62.5 0.3 1e-16 60.5 0.3 2.2 1 0 0 1 1 1 1 Plug domain of Sec61p SdpI PF13630.6 AMD18523.1 - 0.092 12.9 0.2 0.092 12.9 0.2 2.6 3 0 0 3 3 3 0 SdpI/YhfL protein family Glyco_hydro_85 PF03644.13 AMD18524.1 - 1e-57 195.9 3.3 1e-57 195.9 3.3 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 85 Transp_cyt_pur PF02133.15 AMD18525.1 - 2.7e-140 468.0 42.2 3.1e-140 467.8 42.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin zf-C2H2_4 PF13894.6 AMD18526.1 - 1e-06 29.0 25.9 0.00036 21.1 0.9 5.0 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 AMD18526.1 - 0.00063 20.1 1.7 0.00063 20.1 1.7 5.3 4 1 0 4 4 4 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD18526.1 - 0.011 16.2 0.6 0.011 16.2 0.6 4.9 4 1 1 5 5 5 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AMD18526.1 - 0.034 14.4 0.1 0.034 14.4 0.1 4.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Zn-C2H2_12 PF18112.1 AMD18526.1 - 0.037 14.5 0.2 0.22 12.0 0.1 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_6 PF13912.6 AMD18526.1 - 0.043 13.8 14.3 0.062 13.3 1.2 3.8 3 1 0 3 3 3 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 AMD18526.1 - 0.34 11.1 5.1 49 4.1 0.1 3.5 3 0 0 3 3 3 0 Zinc ribbon domain zf-SNAP50_C PF12251.8 AMD18526.1 - 0.37 10.5 8.1 0.05 13.3 1.9 2.0 2 0 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal Rhodanese_C PF12368.8 AMD18526.1 - 0.7 10.3 4.3 14 6.2 0.5 2.6 2 1 0 2 2 2 0 Rhodanase C-terminal zf-Di19 PF05605.12 AMD18526.1 - 0.88 9.9 7.4 4.5 7.7 3.4 3.5 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 AMD18527.1 - 0.0026 17.7 8.8 0.007 16.4 8.8 1.8 1 0 0 1 1 1 1 BED zinc finger zf-IS66 PF13005.7 AMD18527.1 - 0.12 12.8 0.1 0.29 11.6 0.1 1.6 1 0 0 1 1 1 0 zinc-finger binding domain of transposase IS66 ELO PF01151.18 AMD18528.1 - 4e-60 203.4 25.1 5e-60 203.1 25.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CNH PF00780.22 AMD18529.1 - 5.3e-80 268.9 0.5 1.1e-79 267.9 0.1 1.7 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 AMD18529.1 - 3e-38 131.0 0.0 9.1e-38 129.4 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 AMD18529.1 - 3.5e-31 108.9 0.3 1.3e-30 107.0 0.3 2.0 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 AMD18529.1 - 5.3e-15 55.2 0.0 1.2e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) P21-Arc PF04062.14 AMD18530.1 - 8.2e-73 244.1 0.1 9.1e-73 244.0 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit HSP70 PF00012.20 AMD18531.1 - 8.9e-212 704.5 10.6 1e-211 704.3 10.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AMD18531.1 - 2e-17 63.0 6.6 9.5e-16 57.5 2.3 2.6 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AMD18531.1 - 5e-06 26.4 0.0 1.2e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 AMD18531.1 - 0.00044 19.8 0.0 0.055 13.0 0.0 2.9 1 1 1 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Scaffolding_pro PF11418.8 AMD18531.1 - 0.045 14.3 0.5 0.12 13.0 0.5 1.7 1 0 0 1 1 1 0 Phi29 scaffolding protein Nup54 PF13874.6 AMD18531.1 - 0.43 10.7 3.0 9.2 6.4 0.3 3.2 3 1 0 3 3 3 0 Nucleoporin complex subunit 54 FtsA PF14450.6 AMD18531.1 - 0.51 10.8 3.1 4.9 7.6 0.1 3.2 3 2 0 3 3 3 0 Cell division protein FtsA F-box PF00646.33 AMD18532.1 - 0.0025 17.7 2.3 0.013 15.3 2.3 2.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 AMD18532.1 - 0.0028 17.5 3.0 0.0097 15.8 3.0 2.0 1 0 0 1 1 1 1 F-box-like DUF4800 PF16057.5 AMD18532.1 - 0.045 13.0 0.3 0.1 11.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4800) IF4E PF01652.18 AMD18532.1 - 0.3 10.9 2.0 0.59 9.9 2.0 1.4 1 0 0 1 1 1 0 Eukaryotic initiation factor 4E Arrestin_C PF02752.22 AMD18533.1 - 1.1e-09 38.9 0.0 9.6e-09 35.8 0.0 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AMD18533.1 - 0.0006 19.9 0.0 0.0017 18.4 0.0 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain zf-C2H2 PF00096.26 AMD18534.1 - 2.5e-07 30.8 13.5 6.7e-05 23.1 2.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD18534.1 - 0.00015 22.0 4.7 0.00015 22.0 4.7 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD18534.1 - 0.00018 22.1 12.7 0.015 16.1 2.6 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AMD18534.1 - 0.054 13.8 4.9 1.7 9.1 1.2 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Ribosomal_S8 PF00410.19 AMD18535.1 - 1.1e-23 83.5 0.1 1.8e-23 82.9 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 MFS_1 PF07690.16 AMD18536.1 - 7.6e-16 58.0 29.9 2.5e-14 53.0 30.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glutaredoxin PF00462.24 AMD18537.1 - 7.6e-08 32.5 0.2 2e-07 31.1 0.0 1.9 2 1 0 2 2 2 1 Glutaredoxin Thioredoxin_9 PF14595.6 AMD18537.1 - 0.03 14.1 0.1 0.047 13.5 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin DUF953 PF06110.11 AMD18537.1 - 0.063 12.9 0.9 0.086 12.5 0.9 1.4 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_2 PF13098.6 AMD18537.1 - 0.14 12.6 0.0 0.18 12.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Spt4 PF06093.13 AMD18538.1 - 5.2e-29 100.2 0.4 6.1e-29 99.9 0.4 1.0 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger 60KD_IMP PF02096.20 AMD18539.1 - 1e-08 35.3 6.3 7.2e-08 32.5 3.2 2.1 2 0 0 2 2 2 2 60Kd inner membrane protein DUF2462 PF09495.10 AMD18540.1 - 2.3e-15 57.1 11.3 3.1e-15 56.7 11.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) GATase_5 PF13507.6 AMD18541.1 - 4.5e-101 337.3 0.1 6.6e-101 336.8 0.1 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 AMD18541.1 - 1.5e-42 145.3 0.4 1.8e-31 109.4 0.1 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 AMD18541.1 - 6e-26 90.7 0.0 1.2e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 AMD18541.1 - 7.4e-23 80.8 0.1 4.4e-22 78.4 0.0 2.4 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase linker domain FA_hydroxylase PF04116.13 AMD18542.1 - 2.4e-26 92.6 22.2 2.4e-26 92.6 22.2 2.0 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Septin PF00735.18 AMD18543.1 - 3.3e-96 321.9 0.2 3.3e-96 321.9 0.2 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 AMD18543.1 - 1.5e-06 28.3 0.0 3.8e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD18543.1 - 3.7e-05 23.7 0.5 0.00042 20.2 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 AMD18543.1 - 9.2e-05 21.9 0.4 0.0026 17.1 0.1 2.6 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 AMD18543.1 - 0.00024 21.2 0.2 0.16 12.0 0.1 3.1 1 1 1 2 2 2 1 Dynamin family FtsK_SpoIIIE PF01580.18 AMD18543.1 - 0.02 14.3 0.1 0.061 12.7 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_16 PF13191.6 AMD18543.1 - 0.022 15.1 0.0 0.043 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 AMD18543.1 - 0.04 13.4 0.1 0.08 12.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region GTP_EFTU PF00009.27 AMD18543.1 - 0.046 13.3 4.5 3.6 7.1 0.2 3.1 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain T2SSE PF00437.20 AMD18543.1 - 0.052 12.6 0.0 0.086 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 AMD18543.1 - 0.053 13.2 0.4 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 AMD18543.1 - 0.093 12.9 0.1 0.26 11.5 0.1 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 AMD18543.1 - 0.11 12.8 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AMD18543.1 - 0.18 11.8 0.7 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 AMD18543.1 - 4.7 7.2 7.3 1.1 9.3 0.1 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain EF-hand_7 PF13499.6 AMD18544.1 - 2.6e-08 34.2 0.4 0.00028 21.3 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AMD18544.1 - 0.00093 18.9 1.8 2.4 8.3 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 AMD18544.1 - 0.014 14.9 0.0 37 4.2 0.0 4.0 4 0 0 4 4 4 0 EF hand TRAPP PF04051.16 AMD18544.1 - 0.024 14.4 0.1 0.041 13.6 0.1 1.3 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component S10_plectin PF03501.15 AMD18545.1 - 1.2e-41 140.7 0.1 1.3e-41 140.5 0.1 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 AMD18545.1 - 0.072 12.8 0.1 0.098 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Mpv17_PMP22 PF04117.12 AMD18546.1 - 3.8e-18 65.5 0.5 8.3e-18 64.4 0.5 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family P5-ATPase PF12409.8 AMD18547.1 - 2.9e-35 121.1 1.5 2.9e-35 121.1 1.5 2.2 2 0 0 2 2 2 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 AMD18547.1 - 6.4e-31 107.3 0.0 1.4e-30 106.2 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AMD18547.1 - 4.9e-13 49.9 0.0 6.5e-05 23.3 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AMD18547.1 - 0.00034 20.6 0.0 0.00078 19.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AMD18547.1 - 0.0022 17.6 0.0 0.0052 16.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AMD18547.1 - 0.041 13.6 0.1 4.6 6.9 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase S1 PF00575.23 AMD18548.1 - 5.4e-60 199.7 25.3 1.8e-11 44.2 0.7 12.9 11 2 1 13 13 13 9 S1 RNA binding domain TPR_19 PF14559.6 AMD18548.1 - 0.00012 22.5 0.9 0.24 11.9 0.0 3.6 3 1 2 5 5 5 2 Tetratricopeptide repeat Suf PF05843.14 AMD18548.1 - 0.00028 21.0 1.9 0.00028 21.0 1.9 4.8 3 1 2 5 5 5 3 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 AMD18548.1 - 0.015 15.3 4.3 0.24 11.4 0.8 2.7 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 TPR_14 PF13428.6 AMD18548.1 - 0.02 15.7 0.8 27 5.9 0.6 3.8 2 2 2 4 4 4 0 Tetratricopeptide repeat RrnaAD PF00398.20 AMD18550.1 - 9e-46 156.1 0.1 1.2e-45 155.7 0.1 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TAFII55_N PF04658.13 AMD18551.1 - 7.4e-51 172.0 0.0 7.4e-51 172.0 0.0 3.2 3 1 0 3 3 3 1 TAFII55 protein conserved region SNF2_N PF00176.23 AMD18552.1 - 6.1e-70 235.7 0.3 6.1e-70 235.7 0.3 2.8 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD18552.1 - 8.5e-20 71.2 0.0 8.5e-20 71.2 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.6 AMD18552.1 - 7.3e-15 55.3 0.3 7.3e-15 55.3 0.3 4.1 4 1 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex Bromodomain PF00439.25 AMD18552.1 - 2.4e-13 49.9 0.2 1.1e-12 47.9 0.2 2.1 1 0 0 1 1 1 1 Bromodomain RNA_pol_Rpb2_45 PF10385.9 AMD18552.1 - 0.13 12.6 0.1 0.38 11.0 0.1 1.8 1 0 0 1 1 1 0 RNA polymerase beta subunit external 1 domain adh_short PF00106.25 AMD18553.1 - 5.5e-53 179.3 0.0 7e-53 179.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AMD18553.1 - 1.5e-38 132.6 0.0 2e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD18553.1 - 1.4e-13 51.1 0.0 1.9e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 AMD18553.1 - 2.7e-05 23.5 0.1 4.1e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 AMD18553.1 - 9.2e-05 21.9 0.0 0.0002 20.8 0.0 1.5 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 AMD18553.1 - 0.00068 19.2 0.1 0.002 17.7 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 AMD18553.1 - 0.023 14.5 0.1 0.056 13.2 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.6 AMD18553.1 - 0.024 14.5 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding QRPTase_C PF01729.19 AMD18553.1 - 0.065 13.0 0.4 0.3 10.8 0.2 2.0 1 1 1 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain ThiF PF00899.21 AMD18553.1 - 0.24 10.7 0.8 3.4 6.9 0.1 2.1 2 0 0 2 2 2 0 ThiF family Rhodanese PF00581.20 AMD18554.1 - 5.6e-14 52.6 0.0 6.6e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Imm2 PF14426.6 AMD18554.1 - 0.089 12.9 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Immunity protein Imm2 RRP36 PF06102.12 AMD18555.1 - 1e-35 123.1 31.4 1e-35 123.1 31.4 2.0 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 MRP_L53 PF10780.9 AMD18556.1 - 1.8e-16 60.1 0.2 2.5e-16 59.6 0.2 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Thioredoxin PF00085.20 AMD18557.1 - 2.3e-20 72.5 0.2 4.7e-20 71.5 0.2 1.6 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AMD18557.1 - 2.4e-07 31.2 0.1 5.7e-07 30.0 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 AMD18557.1 - 0.0024 17.3 0.1 0.0036 16.7 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 AMD18557.1 - 0.0041 17.3 0.1 0.0084 16.3 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 AMD18557.1 - 0.049 13.4 0.0 0.049 13.4 0.0 2.1 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 AMD18557.1 - 0.056 13.8 0.1 5.9 7.3 0.0 2.7 1 1 1 2 2 2 0 Thioredoxin-like PRESAN PF09687.10 AMD18557.1 - 0.33 11.5 0.1 0.33 11.5 0.1 2.6 3 0 0 3 3 3 0 Plasmodium RESA N-terminal AMMECR1 PF01871.17 AMD18558.1 - 4.7e-38 130.4 0.0 5.5e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 His_Phos_1 PF00300.22 AMD18559.1 - 3.5e-43 147.6 0.0 4.2e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF4142 PF13628.6 AMD18559.1 - 0.096 12.9 0.2 0.74 10.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) Mre11_DNA_bind PF04152.14 AMD18560.1 - 2.1e-47 161.6 0.1 2.1e-47 161.6 0.1 2.4 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 AMD18560.1 - 3.7e-13 50.5 0.3 8.4e-13 49.3 0.3 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AMD18560.1 - 0.0017 18.6 0.0 0.015 15.5 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain F_bP_aldolase PF01116.20 AMD18560.1 - 0.021 14.3 0.0 0.056 12.9 0.0 1.6 2 0 0 2 2 2 0 Fructose-bisphosphate aldolase class-II Phosducin PF02114.16 AMD18561.1 - 4e-15 55.5 0.9 5.3e-15 55.1 0.9 1.2 1 0 0 1 1 1 1 Phosducin rRNA_processing PF08524.11 AMD18561.1 - 0.04 13.9 0.6 0.04 13.9 0.6 1.9 2 0 0 2 2 2 0 rRNA processing Flavodoxin_2 PF02525.17 AMD18561.1 - 0.087 12.5 0.3 0.64 9.7 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin-like fold UCH PF00443.29 AMD18562.1 - 1.9e-53 181.6 0.1 2.3e-53 181.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD18562.1 - 5.1e-19 69.0 0.7 4.1e-18 66.0 0.7 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AMD18562.1 - 5.9e-11 42.5 7.2 5.9e-11 42.5 7.2 2.4 2 1 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein FSH1 PF03959.13 AMD18563.1 - 3.2e-57 193.6 0.0 3.6e-57 193.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 AMD18563.1 - 0.0025 17.7 0.0 0.015 15.1 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 AMD18564.1 - 2.2e-66 223.5 0.0 2.6e-66 223.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 AMD18564.1 - 0.0045 16.8 0.1 0.011 15.5 0.0 1.7 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 AMD18564.1 - 0.041 14.5 0.0 0.051 14.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family GHMP_kinases_N PF00288.26 AMD18566.1 - 3.2e-15 56.1 0.1 6.4e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AMD18566.1 - 1.9e-05 24.9 0.0 5e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal TRAPPC10 PF12584.8 AMD18568.1 - 1e-10 41.5 0.0 2.5e-10 40.3 0.0 1.6 1 1 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 DUF3760 PF12586.8 AMD18568.1 - 0.051 13.8 0.1 0.15 12.2 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) HEM4 PF02602.15 AMD18569.1 - 2.1e-47 161.4 0.0 2.4e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Med20 PF08612.11 AMD18569.1 - 0.0059 16.0 0.0 0.0096 15.3 0.0 1.3 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex GMP_synt_C PF00958.22 AMD18570.1 - 6e-45 151.2 0.0 1.2e-44 150.3 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 AMD18570.1 - 1.6e-41 142.2 0.0 3.1e-41 141.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 AMD18570.1 - 2.2e-07 30.2 0.0 2.5e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 AMD18570.1 - 1.8e-06 27.9 0.1 8.2e-06 25.7 0.1 2.1 1 1 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 AMD18570.1 - 0.0038 16.1 0.1 0.0086 14.9 0.0 1.6 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 AMD18570.1 - 0.023 14.2 0.0 0.36 10.3 0.0 2.1 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 AMD18570.1 - 0.027 14.5 0.0 0.046 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.19 AMD18570.1 - 0.036 13.4 0.1 0.064 12.5 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ThiI PF02568.14 AMD18570.1 - 0.081 12.5 0.0 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) RRM_1 PF00076.22 AMD18571.1 - 3.1e-11 42.9 0.0 6e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AMD18571.1 - 1.6e-08 34.4 0.0 2.7e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Pkinase PF00069.25 AMD18572.1 - 1.9e-41 142.2 1.0 2.5e-19 69.7 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18572.1 - 8.8e-10 38.3 1.7 1.8e-05 24.2 1.0 3.2 2 1 0 2 2 2 2 Protein tyrosine kinase Glyco_hydro_72 PF03198.14 AMD18573.1 - 1.4e-116 389.2 0.7 2.6e-116 388.3 0.7 1.3 1 0 0 1 1 1 1 Glucanosyltransferase DnaJ PF00226.31 AMD18574.1 - 6.6e-28 96.6 1.5 1e-27 96.0 1.5 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 AMD18574.1 - 9.6e-24 84.2 0.1 1.2e-23 83.8 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 AMD18574.1 - 4e-15 55.9 18.4 6.9e-15 55.2 18.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AMD18574.1 - 0.0011 18.8 11.2 0.086 12.8 1.9 2.4 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein A2L_zn_ribbon PF08792.10 AMD18574.1 - 1.5 8.7 9.8 6.8 6.5 0.7 3.4 2 1 1 3 3 3 0 A2L zinc ribbon domain zinc-ribbons_6 PF07191.12 AMD18574.1 - 3.2 7.8 10.4 8.7 6.4 10.4 1.7 1 1 0 1 1 1 0 zinc-ribbons HypA PF01155.19 AMD18574.1 - 6.9 6.7 12.7 9.7 6.3 1.6 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CAF20 PF17052.5 AMD18575.1 - 1.2e-42 145.8 2.5 2.5e-42 144.8 2.5 1.5 1 1 0 1 1 1 1 Cap associated factor Myb_DNA-binding PF00249.31 AMD18576.1 - 8.1e-22 77.1 9.2 1.3e-13 50.9 0.7 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD18576.1 - 4.7e-20 71.6 4.4 2.9e-13 49.8 2.5 3.4 2 1 1 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.8 AMD18576.1 - 1.5e-07 31.4 0.0 0.001 19.1 0.0 3.6 3 1 0 3 3 3 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_Cef PF11831.8 AMD18576.1 - 0.0012 18.4 0.0 0.0012 18.4 0.0 3.4 2 1 0 2 2 2 1 pre-mRNA splicing factor component MLTR_LBD PF17765.1 AMD18576.1 - 0.09 12.9 0.9 0.24 11.5 0.9 1.7 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain RPEL PF02755.15 AMD18576.1 - 1.2 9.0 4.9 4.1 7.2 0.4 2.7 2 0 0 2 2 2 0 RPEL repeat BRO1 PF03097.18 AMD18578.1 - 2e-88 296.8 5.1 3.7e-88 296.0 5.1 1.4 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 AMD18578.1 - 4.3e-16 59.1 20.0 5.4e-14 52.2 18.2 2.8 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV IPPT PF01715.17 AMD18579.1 - 4.6e-66 222.9 1.7 6.5e-66 222.4 1.7 1.1 1 0 0 1 1 1 1 IPP transferase AAA_33 PF13671.6 AMD18579.1 - 0.00037 20.7 0.0 0.0014 18.8 0.0 2.1 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 AMD18579.1 - 0.00055 20.5 0.0 0.0061 17.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain IPT PF01745.16 AMD18579.1 - 0.0011 18.5 0.6 0.0076 15.7 0.0 2.5 3 1 1 4 4 4 1 Isopentenyl transferase Zeta_toxin PF06414.12 AMD18579.1 - 0.0034 16.7 0.4 0.012 14.9 0.1 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 AMD18579.1 - 0.0073 16.6 0.1 0.27 11.5 0.1 2.9 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.22 AMD18579.1 - 0.023 15.1 0.0 0.077 13.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 AMD18579.1 - 0.051 13.1 0.1 0.099 12.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AMD18579.1 - 0.052 13.4 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase ParA PF10609.9 AMD18579.1 - 0.054 12.9 0.2 0.11 11.9 0.2 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase Hpr_kinase_C PF07475.12 AMD18579.1 - 0.089 12.3 0.1 0.37 10.3 0.0 2.0 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain CbiA PF01656.23 AMD18579.1 - 0.13 12.3 0.4 0.36 10.9 0.4 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Tubulin_3 PF14881.6 AMD18580.1 - 1.8e-21 76.6 0.0 6e-21 74.9 0.0 1.9 1 1 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 AMD18580.1 - 9.3e-13 48.5 0.1 4e-12 46.5 0.0 2.0 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 AMD18580.1 - 0.0028 17.9 0.0 0.0069 16.6 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain MFS_1 PF07690.16 AMD18581.1 - 9.3e-29 100.4 38.8 1.4e-28 99.8 33.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AMD18581.1 - 6.6e-06 25.3 2.1 6.6e-06 25.3 2.1 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter PP1c_bdg PF10488.9 AMD18581.1 - 0.026 14.0 0.9 0.035 13.6 0.9 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region N2227 PF07942.12 AMD18582.1 - 6.7e-64 215.7 0.4 9e-64 215.3 0.4 1.1 1 0 0 1 1 1 1 N2227-like protein WD40 PF00400.32 AMD18583.1 - 3e-24 84.8 8.4 1.2e-05 26.0 0.0 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.12 AMD18583.1 - 2.2e-22 79.3 0.1 4.6e-22 78.3 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 AMD18583.1 - 1.3e-08 34.0 5.4 0.00049 18.9 0.6 2.7 2 1 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 AMD18583.1 - 0.0042 16.5 0.0 0.03 13.6 0.0 2.4 1 1 1 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 AMD18583.1 - 0.05 13.9 0.1 0.6 10.5 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Mtc PF03820.17 AMD18584.1 - 9.7e-125 415.7 0.3 1.1e-124 415.6 0.3 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier SecD_SecF PF02355.16 AMD18584.1 - 0.045 13.1 0.3 0.077 12.4 0.3 1.3 1 0 0 1 1 1 0 Protein export membrane protein GHMP_kinases_N PF00288.26 AMD18585.1 - 2.5e-19 69.3 0.5 2.5e-19 69.3 0.5 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AMD18585.1 - 1.7e-07 31.5 0.1 5.5e-07 29.9 0.0 1.9 1 1 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 AMD18585.1 - 0.16 11.5 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature V_ATPase_I PF01496.19 AMD18586.1 - 1.1e-297 989.4 5.5 1.3e-297 989.3 5.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Snapin_Pallidin PF14712.6 AMD18586.1 - 0.47 10.9 3.3 0.32 11.5 0.3 2.2 2 0 0 2 2 2 0 Snapin/Pallidin WD40 PF00400.32 AMD18587.1 - 2e-19 69.5 14.2 1.3e-05 25.8 0.5 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 AMD18587.1 - 4.8e-05 22.2 0.9 0.058 12.0 0.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 AMD18587.1 - 0.039 14.3 0.0 56 4.1 0.0 3.9 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 AMD18588.1 - 2.5e-48 164.7 0.0 1.5e-47 162.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18588.1 - 1.2e-19 70.6 0.1 5.3e-19 68.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 AMD18588.1 - 0.021 14.8 0.0 0.38 10.6 0.0 2.4 1 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 AMD18588.1 - 0.074 12.3 0.0 0.25 10.6 0.0 1.8 1 1 1 2 2 2 0 Kinase-like DUF223 PF02721.14 AMD18588.1 - 0.2 12.0 2.5 0.24 11.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF223 TBCA PF02970.16 AMD18590.1 - 3.2e-24 85.1 9.6 3.8e-24 84.8 9.6 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A Cytochrom_C_2 PF01322.20 AMD18590.1 - 0.0054 17.6 0.7 0.0066 17.3 0.7 1.1 1 0 0 1 1 1 1 Cytochrome C' MA-Mit PF09245.10 AMD18590.1 - 0.0062 16.0 1.8 0.0071 15.9 1.8 1.2 1 1 0 1 1 1 1 Mycoplasma arthritidis-derived mitogen ZapD PF07072.11 AMD18590.1 - 0.0092 15.8 0.5 0.012 15.4 0.5 1.3 1 0 0 1 1 1 1 Cell division protein HMMR_N PF15905.5 AMD18590.1 - 0.063 12.7 8.9 0.079 12.4 8.9 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal FapA PF03961.13 AMD18590.1 - 0.082 11.5 6.3 0.089 11.4 6.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF5339 PF17274.2 AMD18590.1 - 1.2 10.1 7.8 2.3 9.1 0.7 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5339) CAP59_mtransfer PF11735.8 AMD18591.1 - 0.089 12.5 0.4 0.14 11.8 0.4 1.2 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 Na_Ca_ex PF01699.24 AMD18592.1 - 2.4e-19 69.8 45.3 1e-15 58.0 11.5 3.7 4 1 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 AMD18592.1 - 2.6e-13 50.4 5.6 2.6e-13 50.4 5.6 4.8 5 1 0 5 5 5 1 Inner membrane component domain Neurensin PF14927.6 AMD18592.1 - 0.00085 19.0 0.1 0.0039 16.9 0.1 2.2 1 0 0 1 1 1 1 Neurensin PepSY_TM PF03929.16 AMD18592.1 - 0.021 14.5 0.3 1.4 8.5 0.1 2.4 2 0 0 2 2 2 0 PepSY-associated TM region VanZ PF04892.12 AMD18592.1 - 0.33 11.6 0.1 0.33 11.6 0.1 4.1 3 2 1 4 4 4 0 VanZ like family CCB1 PF12046.8 AMD18592.1 - 5.6 6.3 5.8 8 5.8 0.0 3.4 3 1 0 3 3 3 0 Cofactor assembly of complex C subunit B IF4E PF01652.18 AMD18593.1 - 1.7e-52 177.4 0.1 2e-52 177.2 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Toprim_Crpt PF13342.6 AMD18593.1 - 0.06 13.3 0.3 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase Hydrolase_4 PF12146.8 AMD18594.1 - 6.4e-17 61.6 0.0 1.6e-08 34.1 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AMD18594.1 - 1.3e-11 44.6 0.0 1.2e-06 28.3 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 AMD18594.1 - 3.7e-05 23.3 0.0 0.00034 20.2 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 AMD18594.1 - 0.0015 19.1 0.0 0.0023 18.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 AMD18594.1 - 0.0031 17.2 0.0 0.0038 16.9 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 AMD18594.1 - 0.0036 17.2 0.0 0.9 9.4 0.0 2.2 1 1 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 AMD18594.1 - 0.083 12.4 0.0 4.7 6.7 0.1 2.3 1 1 0 2 2 2 0 Lipid-droplet associated hydrolase DUF1749 PF08538.10 AMD18594.1 - 0.14 11.2 0.0 0.3 10.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Peptidase_S15 PF02129.18 AMD18594.1 - 0.23 11.0 0.0 0.79 9.3 0.0 1.8 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Zn_ribbon_17 PF17120.5 AMD18595.1 - 1.6e-10 40.5 3.4 1.6e-10 40.5 3.4 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AMD18595.1 - 8.6e-10 39.1 5.4 0.0014 19.4 0.0 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat zf-rbx1 PF12678.7 AMD18595.1 - 0.001 19.3 8.7 0.0027 17.9 8.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AMD18595.1 - 0.0028 18.0 5.2 0.0028 18.0 5.2 1.9 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 AMD18595.1 - 0.16 12.0 6.5 0.37 10.9 6.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 AMD18595.1 - 2.9 7.9 9.6 0.46 10.4 4.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD18595.1 - 5.6 6.9 10.8 0.94 9.4 6.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 AMD18596.1 - 2.1e-28 98.0 15.7 4.8e-07 30.4 0.2 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD18596.1 - 7.7e-19 67.8 0.6 0.038 14.3 0.0 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD18596.1 - 4.2e-06 26.8 1.7 0.091 12.6 0.0 3.6 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AMD18596.1 - 0.00086 18.4 1.2 2.6 6.9 0.0 3.8 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 AMD18596.1 - 0.0013 17.1 0.2 0.11 10.8 0.0 2.4 1 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 AMD18596.1 - 0.0051 16.2 0.0 0.15 11.3 0.0 2.2 1 1 1 2 2 2 1 WD40-like domain 6PF2K PF01591.18 AMD18597.1 - 7.8e-51 172.5 1.8 1.3e-50 171.8 1.8 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 AMD18597.1 - 0.00015 22.0 0.0 0.00027 21.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD18597.1 - 0.0021 18.6 0.1 0.0079 16.7 0.0 2.0 1 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 AMD18597.1 - 0.0026 17.3 0.0 0.005 16.3 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 AMD18597.1 - 0.065 13.6 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Med7 PF05983.11 AMD18598.1 - 2.5e-63 213.6 2.2 2.9e-63 213.4 2.2 1.0 1 0 0 1 1 1 1 MED7 protein Med4 PF10018.9 AMD18598.1 - 3.1 7.5 6.8 0.53 9.9 3.2 1.5 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 zf-rbx1 PF12678.7 AMD18599.1 - 2.3e-23 82.2 13.4 3.9e-23 81.5 13.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AMD18599.1 - 8.8e-17 60.9 10.7 1.1e-16 60.6 10.7 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 AMD18599.1 - 4e-06 27.1 13.9 0.00016 21.9 13.9 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AMD18599.1 - 0.00028 20.7 3.7 0.00028 20.7 3.7 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD18599.1 - 0.0017 18.2 12.0 0.0079 16.1 12.0 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AMD18599.1 - 0.0023 17.7 0.9 0.0023 17.7 0.9 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-HC5HC2H PF13771.6 AMD18599.1 - 0.36 11.1 10.5 25 5.2 10.5 2.1 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_UBOX PF13445.6 AMD18599.1 - 0.73 9.9 8.9 3.3 7.8 8.9 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 AMD18599.1 - 1.7 8.9 10.1 7.7 6.8 10.3 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 AMD18599.1 - 4 7.1 14.5 0.52 10.0 4.6 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 AMD18599.1 - 6.2 6.9 11.4 30 4.7 11.4 2.1 1 1 0 1 1 1 0 zinc-RING finger domain PDT PF00800.18 AMD18600.1 - 3e-51 173.8 0.4 3.9e-51 173.5 0.4 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 AMD18600.1 - 0.0064 16.2 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 ACT domain 2HCT PF03390.15 AMD18600.1 - 0.16 10.6 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family ATP11 PF06644.11 AMD18601.1 - 7.2e-90 301.5 4.7 8.3e-90 301.3 4.7 1.0 1 0 0 1 1 1 1 ATP11 protein TPR_8 PF13181.6 AMD18602.1 - 2e-09 36.9 1.7 0.011 15.9 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 AMD18602.1 - 1.4e-07 31.7 0.8 1.7 9.6 0.1 5.7 5 1 1 6 6 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 AMD18602.1 - 1.9e-07 30.7 1.2 0.01 15.9 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 AMD18602.1 - 1.9e-06 28.3 0.1 0.038 14.5 0.0 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 AMD18602.1 - 3.1e-06 26.8 1.1 0.19 11.6 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD18602.1 - 4e-05 23.8 1.4 0.018 15.3 0.1 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 AMD18602.1 - 0.00017 21.7 1.8 0.017 15.4 0.0 4.3 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 AMD18602.1 - 0.00093 18.8 0.0 1.1 9.1 0.0 3.9 2 1 1 3 3 3 1 TPR repeat TPR_10 PF13374.6 AMD18602.1 - 0.0031 17.3 0.5 0.07 13.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 AMD18602.1 - 0.0076 16.9 0.2 0.19 12.4 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 AMD18602.1 - 0.038 14.1 1.9 0.41 10.8 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 AMD18602.1 - 0.069 12.4 0.0 0.51 9.5 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ChAPs PF09295.10 AMD18602.1 - 0.083 11.9 0.2 0.25 10.3 0.1 1.8 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.9 AMD18602.1 - 0.094 12.4 0.4 0.47 10.1 0.1 2.3 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_7 PF13176.6 AMD18602.1 - 0.28 11.3 2.1 12 6.1 0.0 4.3 5 1 0 5 5 5 0 Tetratricopeptide repeat RPA_C PF08784.11 AMD18603.1 - 1.2e-08 35.5 0.2 5.1e-08 33.5 0.0 2.1 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 AMD18603.1 - 4.2e-07 29.9 0.7 9.4e-07 28.7 0.7 1.6 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 AMD18603.1 - 0.0075 16.0 1.0 0.014 15.1 0.1 1.7 2 0 0 2 2 2 1 Cell division control protein 24, OB domain 3 Barwin PF00967.17 AMD18603.1 - 0.12 12.2 0.3 0.29 11.0 0.2 1.7 1 1 0 1 1 1 0 Barwin family Glyco_hydro_72 PF03198.14 AMD18604.1 - 7e-135 449.3 2.3 9.2e-135 448.9 2.3 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 AMD18604.1 - 0.0015 18.0 0.6 0.0074 15.7 0.6 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) zf-DNL PF05180.12 AMD18605.1 - 3.6e-31 106.9 1.4 6.1e-31 106.2 1.4 1.4 1 0 0 1 1 1 1 DNL zinc finger HypA PF01155.19 AMD18605.1 - 0.024 14.7 0.4 0.038 14.0 0.4 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-CSL PF05207.13 AMD18605.1 - 0.065 13.0 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 CSL zinc finger zinc_ribbon_4 PF13717.6 AMD18605.1 - 0.42 10.6 4.1 4.4 7.3 0.1 2.4 1 1 1 2 2 2 0 zinc-ribbon domain CorA PF01544.18 AMD18607.1 - 6.1e-39 134.1 0.8 2.1e-22 79.8 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein Kri1_C PF12936.7 AMD18608.1 - 2.4e-31 107.7 3.8 2.4e-31 107.7 3.8 4.4 4 1 1 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 AMD18608.1 - 1.7e-15 57.4 9.0 1.7e-15 57.4 9.0 5.9 4 2 1 5 5 5 1 KRI1-like family UPF0220 PF05255.11 AMD18609.1 - 1.5e-59 200.3 2.8 1.7e-59 200.1 2.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Phage_holin_5_2 PF16079.5 AMD18609.1 - 0.12 12.7 6.7 0.4 11.1 0.3 2.8 2 1 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V Pkinase PF00069.25 AMD18610.1 - 2.2e-58 197.7 0.0 2.6e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18610.1 - 2.6e-29 102.3 0.0 3.5e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD18610.1 - 3.6e-06 26.5 0.0 5.3e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD18610.1 - 0.002 18.1 0.0 0.0058 16.6 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 AMD18610.1 - 0.0022 17.4 0.1 0.0033 16.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AMD18610.1 - 0.061 12.9 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_S11 PF00411.19 AMD18611.1 - 0.013 15.9 0.0 0.02 15.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S11 Dicer_dimer PF03368.14 AMD18611.1 - 0.061 13.5 0.0 0.095 12.9 0.0 1.3 1 0 0 1 1 1 0 Dicer dimerisation domain Ribosomal_L23eN PF03939.13 AMD18612.1 - 3.5e-20 72.0 8.9 3.5e-20 72.0 8.9 1.9 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 AMD18612.1 - 6.6e-16 58.5 3.0 6.6e-16 58.5 3.0 2.8 2 2 0 2 2 2 1 Ribosomal protein L23 DUF3098 PF11297.8 AMD18613.1 - 0.0026 17.3 0.1 0.01 15.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3098) Transposase_28 PF04195.12 AMD18613.1 - 0.064 13.5 0.1 0.064 13.5 0.1 1.8 2 0 0 2 2 2 0 Putative gypsy type transposon DUF5336 PF17270.2 AMD18613.1 - 0.066 12.8 0.1 0.58 9.8 0.0 2.0 1 1 0 2 2 2 0 Family of unknown function (DUF5336) Ldh_1_C PF02866.18 AMD18614.1 - 3.7e-39 134.3 0.0 5.8e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 AMD18614.1 - 1.4e-35 122.4 0.1 2.9e-35 121.4 0.1 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain TRM13 PF05206.14 AMD18615.1 - 5.2e-77 258.9 0.3 1.7e-76 257.2 0.3 1.8 1 1 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 AMD18615.1 - 3.3e-13 49.2 3.0 3.3e-13 49.2 3.0 2.0 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 AMD18615.1 - 1.1e-09 38.0 1.9 1.1e-09 38.0 1.9 2.5 2 0 0 2 2 2 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.6 AMD18615.1 - 0.00028 20.9 2.2 0.0053 16.8 2.2 2.5 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 AMD18616.1 - 2.3e-09 37.3 0.0 4e-08 33.2 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 AMD18616.1 - 0.019 14.2 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase N6_N4_Mtase PF01555.18 AMD18616.1 - 0.13 11.9 0.1 14 5.3 0.0 2.3 2 0 0 2 2 2 0 DNA methylase RRM_1 PF00076.22 AMD18617.1 - 2.2e-34 117.1 0.1 5.8e-17 61.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD18617.1 - 1e-10 41.6 0.1 7.4e-05 22.8 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif TFIIA PF03153.13 AMD18617.1 - 6.3 6.7 34.9 8 6.3 17.1 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Nramp PF01566.18 AMD18618.1 - 4.9e-86 288.9 24.8 3.6e-50 170.9 4.2 2.5 3 0 0 3 3 3 2 Natural resistance-associated macrophage protein Ribosomal_S19e PF01090.19 AMD18619.1 - 7.4e-53 177.9 0.0 9.2e-53 177.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L18 PF17135.4 AMD18620.1 - 1.9e-82 275.2 3.9 2.2e-82 275.0 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 AMD18620.1 - 0.011 16.4 0.4 0.011 16.4 0.4 2.0 2 1 0 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A MFS_1 PF07690.16 AMD18621.1 - 1.5e-27 96.5 36.2 1.5e-27 96.5 36.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AMD18621.1 - 0.0001 21.3 4.0 0.0001 21.3 4.0 3.6 2 2 2 4 4 4 2 Sugar (and other) transporter Arm-DNA-bind_4 PF14657.6 AMD18621.1 - 0.045 13.5 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 Arm DNA-binding domain Redoxin PF08534.10 AMD18622.1 - 1.9e-26 92.6 0.0 2.2e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 AMD18622.1 - 9.2e-10 38.5 0.0 1.2e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family PH_BEACH PF14844.6 AMD18623.1 - 0.091 12.9 0.2 0.7 10.0 0.1 2.2 2 0 0 2 2 2 0 PH domain associated with Beige/BEACH GCR1_C PF12550.8 AMD18624.1 - 5.6e-23 81.1 0.1 1.2e-22 80.0 0.1 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Fib_alpha PF08702.10 AMD18624.1 - 0.054 13.7 2.1 0.15 12.2 2.1 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Yae1_N PF09811.9 AMD18625.1 - 0.058 13.1 3.4 0.13 12.0 3.4 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DUF1451 PF07295.11 AMD18625.1 - 0.78 9.8 3.4 0.47 10.5 0.6 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain TDA11 PF17084.5 AMD18626.1 - 1.3e-32 113.4 15.9 1.1e-31 110.3 13.0 2.5 1 1 1 2 2 2 1 Topoisomerase I damage affected protein 11 YscO-like PF16789.5 AMD18626.1 - 0.022 14.8 1.6 0.054 13.5 1.6 1.6 1 0 0 1 1 1 0 YscO-like protein DUF3597 PF12200.8 AMD18626.1 - 0.55 10.8 0.1 0.55 10.8 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3597) Kelch_5 PF13854.6 AMD18627.1 - 3.3e-27 94.0 7.2 8.5e-05 22.4 0.3 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 AMD18627.1 - 3.8e-27 94.0 1.0 1.5e-05 25.2 0.0 6.0 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 AMD18627.1 - 3.3e-26 91.0 5.1 0.00032 20.6 0.1 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 AMD18627.1 - 5.5e-22 77.3 6.9 0.0025 18.0 0.0 6.7 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.25 AMD18627.1 - 6.1e-16 57.7 0.4 7.8e-05 22.2 0.0 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 AMD18627.1 - 2.1e-12 46.5 7.0 0.15 12.1 0.1 6.9 7 0 0 7 7 7 6 Kelch motif TPR_MLP1_2 PF07926.12 AMD18627.1 - 0.00072 19.6 9.0 0.00072 19.6 9.0 5.1 4 1 2 6 6 6 1 TPR/MLP1/MLP2-like protein XhlA PF10779.9 AMD18627.1 - 2.9 8.2 5.8 16 5.8 0.9 3.4 3 0 0 3 3 3 0 Haemolysin XhlA REC104 PF17378.2 AMD18628.1 - 0.00044 20.1 0.1 0.0022 17.9 0.0 1.9 2 0 0 2 2 2 1 Meiotic recombination protein REC104 Usp PF00582.26 AMD18629.1 - 0.059 13.9 0.1 2.2 8.8 0.0 2.8 3 0 0 3 3 3 0 Universal stress protein family DUF1081 PF06448.11 AMD18629.1 - 0.3 11.5 1.9 1.5 9.2 0.2 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1081) ApoO PF09769.9 AMD18631.1 - 4.6e-30 104.2 0.0 7.6e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Apolipoprotein O RTT107_BRCT_6 PF16771.5 AMD18632.1 - 6.1e-36 123.0 0.2 4.7e-35 120.2 0.0 2.6 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 AMD18632.1 - 2e-26 92.2 4.4 5.8e-05 23.4 0.1 6.2 5 1 0 5 5 5 5 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 AMD18632.1 - 3.8e-25 87.7 0.1 3e-22 78.4 0.0 3.7 5 0 0 5 5 5 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 AMD18632.1 - 3e-20 71.9 3.2 4.4e-15 55.4 0.4 4.9 7 0 0 7 7 7 2 twin BRCT domain BRCT_2 PF16589.5 AMD18632.1 - 2.2e-15 56.9 0.8 0.0014 19.0 0.0 5.5 5 0 0 5 5 5 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 AMD18632.1 - 1.5e-05 25.2 5.6 0.045 14.0 0.0 4.5 5 0 0 5 5 5 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 AMD18632.1 - 0.00029 20.8 1.4 0.33 11.0 0.0 4.5 6 0 0 6 6 6 1 BRCA1 C Terminus (BRCT) domain Siah-Interact_N PF09032.11 AMD18632.1 - 0.075 13.4 2.2 0.26 11.6 2.2 2.0 1 0 0 1 1 1 0 Siah interacting protein, N terminal Cir_N PF10197.9 AMD18633.1 - 0.013 15.7 2.8 0.013 15.7 2.8 2.8 3 0 0 3 3 3 0 N-terminal domain of CBF1 interacting co-repressor CIR bZIP_Maf PF03131.17 AMD18633.1 - 0.58 10.7 11.2 0.24 11.9 7.6 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor Ank_2 PF12796.7 AMD18635.1 - 2e-37 127.6 7.3 1.6e-15 57.5 0.0 3.7 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AMD18635.1 - 5.9e-23 80.9 0.9 2.5e-09 37.5 0.1 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) SPX PF03105.19 AMD18635.1 - 2e-20 74.0 13.0 6.4e-11 42.8 1.4 3.3 1 1 2 3 3 3 3 SPX domain Ank_5 PF13857.6 AMD18635.1 - 2e-19 69.4 5.0 8.1e-05 22.8 0.0 6.0 1 1 5 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 AMD18635.1 - 1.7e-17 63.0 1.2 0.0029 18.0 0.1 6.6 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 AMD18635.1 - 2.7e-16 58.0 5.0 0.0084 16.5 0.0 7.4 8 0 0 8 8 8 4 Ankyrin repeat GDPD PF03009.17 AMD18635.1 - 0.0005 19.9 0.0 0.0018 18.0 0.0 2.0 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 AMD18636.1 - 1.5e-33 115.2 0.1 1e-11 45.2 0.0 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 AMD18636.1 - 4.7e-29 97.2 0.0 0.00014 22.0 0.0 6.8 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.6 AMD18636.1 - 1.6e-28 98.7 0.4 6.5e-09 36.2 0.0 4.7 3 2 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 AMD18636.1 - 6.3e-24 83.7 0.1 2.2e-05 24.7 0.0 5.9 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 AMD18636.1 - 8.7e-19 67.1 0.0 1.6e-05 25.1 0.0 5.9 7 0 0 7 7 7 4 Ankyrin repeat Band_7 PF01145.25 AMD18637.1 - 1.7e-21 77.0 0.6 2.9e-21 76.3 0.6 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Methyltransf_5 PF01795.19 AMD18637.1 - 0.012 15.2 0.6 0.018 14.6 0.6 1.3 1 0 0 1 1 1 0 MraW methylase family AIRS_C PF02769.22 AMD18637.1 - 0.042 14.0 0.6 0.1 12.7 0.5 1.8 2 1 0 2 2 2 0 AIR synthase related protein, C-terminal domain DOG1 PF14144.6 AMD18637.1 - 0.14 12.4 0.0 11 6.3 0.0 2.4 2 0 0 2 2 2 0 Seed dormancy control Spo12 PF05032.12 AMD18638.1 - 1.1e-18 66.8 4.1 1.1e-18 66.8 4.1 2.2 2 0 0 2 2 2 1 Spo12 family LUC7 PF03194.15 AMD18638.1 - 0.0085 15.8 1.5 0.024 14.3 0.1 1.9 1 1 1 2 2 2 1 LUC7 N_terminus SMI1_KNR4 PF09346.10 AMD18639.1 - 2.1e-32 112.3 0.0 9.3e-32 110.2 0.0 2.1 2 1 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) DIE2_ALG10 PF04922.12 AMD18640.1 - 2.6e-106 356.2 41.8 2.6e-106 356.2 41.8 1.4 2 0 0 2 2 2 1 DIE2/ALG10 family DUF4519 PF15012.6 AMD18640.1 - 3.3 7.9 10.5 0.24 11.6 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) Lectin_C PF00059.21 AMD18641.1 - 6.5e-05 23.6 2.6 0.0053 17.5 0.4 3.2 3 0 0 3 3 3 2 Lectin C-type domain Pex24p PF06398.11 AMD18642.1 - 2.4e-72 243.9 4.1 3.1e-72 243.6 4.1 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF639 PF04842.12 AMD18642.1 - 0.00037 20.0 1.0 0.00053 19.5 0.1 1.7 2 0 0 2 2 2 1 Plant protein of unknown function (DUF639) Reticulon PF02453.17 AMD18642.1 - 0.012 15.6 0.7 0.66 9.9 0.1 2.3 2 0 0 2 2 2 0 Reticulon PRT_C PF08372.10 AMD18642.1 - 0.49 10.1 3.3 1.3 8.7 0.4 2.2 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal WD40 PF00400.32 AMD18643.1 - 1.1e-09 38.8 8.4 0.063 14.2 0.1 6.4 8 0 0 8 8 8 3 WD domain, G-beta repeat WD40_like PF17005.5 AMD18643.1 - 0.0045 16.4 0.0 2.9 7.1 0.0 2.6 2 1 0 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 AMD18644.1 - 0.028 14.7 0.1 0.68 10.3 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain SKG6 PF08693.10 AMD18646.1 - 0.011 15.1 6.7 0.018 14.4 6.7 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ribosomal_S4 PF00163.19 AMD18647.1 - 4.4e-13 50.0 3.7 5.4e-13 49.7 3.3 1.4 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 AMD18647.1 - 1.7e-11 43.6 0.0 3.2e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain Ribosomal_L6 PF00347.23 AMD18648.1 - 6.9e-19 68.3 0.4 6.5e-09 36.3 0.2 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 DUF3868 PF12984.7 AMD18648.1 - 0.1 12.4 0.1 0.68 9.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3868) Ribosomal_L3 PF00297.22 AMD18649.1 - 1e-16 60.9 5.9 5e-16 58.6 2.4 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 CRM1_C PF08767.11 AMD18650.1 - 6.1e-132 439.6 3.5 6.1e-132 439.6 3.5 3.6 4 1 0 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 AMD18650.1 - 8.2e-38 129.8 7.2 8.2e-38 129.8 7.2 3.2 3 0 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 AMD18650.1 - 2e-30 104.2 1.4 7.1e-30 102.5 1.4 2.1 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 AMD18650.1 - 1.5e-29 101.9 1.4 6.7e-29 99.8 0.4 2.8 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 AMD18650.1 - 2.4e-16 58.9 1.2 2.4e-16 58.9 1.2 2.3 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 AMD18650.1 - 2.9e-15 56.0 1.4 2.5e-13 49.7 0.1 3.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3385 PF11865.8 AMD18650.1 - 0.013 15.4 5.0 0.13 12.1 0.0 4.3 4 1 0 4 4 4 0 Domain of unknown function (DUF3385) V-ATPase_H_C PF11698.8 AMD18650.1 - 0.029 14.5 1.6 1.2 9.3 0.2 3.6 2 0 0 2 2 2 0 V-ATPase subunit H PLN_propep PF16485.5 AMD18650.1 - 0.086 12.6 0.0 0.4 10.4 0.0 2.1 2 0 0 2 2 2 0 Protealysin propeptide DUF507 PF04368.13 AMD18650.1 - 0.17 11.8 6.7 4.2 7.3 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF507) Symplekin_C PF12295.8 AMD18650.1 - 0.32 11.1 0.0 0.32 11.1 0.0 4.1 5 1 0 5 5 5 0 Symplekin tight junction protein C terminal Ion_trans PF00520.31 AMD18651.1 - 4.3e-93 311.1 105.6 2.1e-32 112.3 13.0 5.0 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.32 AMD18651.1 - 0.00055 19.3 0.0 0.0051 16.3 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 AMD18651.1 - 0.026 14.5 0.0 0.11 12.5 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain Gpi1 PF05024.15 AMD18652.1 - 1.3e-59 201.4 18.3 2.7e-59 200.4 18.3 1.6 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) MRP-S33 PF08293.11 AMD18653.1 - 2.9e-33 113.9 0.1 3.6e-33 113.7 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ribosomal_S2 PF00318.20 AMD18654.1 - 5e-23 81.5 0.2 1.3e-12 47.4 0.0 2.3 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 AMD18654.1 - 4.8e-06 27.8 7.4 1.1e-05 26.7 7.4 1.6 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus AATase PF07247.12 AMD18655.1 - 4.7e-44 150.8 2.4 6.6e-43 147.0 2.4 2.2 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 AMD18655.1 - 3.2e-07 29.4 0.1 0.0025 16.6 0.1 2.1 2 0 0 2 2 2 2 Condensation domain zf-ZPR1 PF03367.13 AMD18656.1 - 8.4e-114 376.7 9.8 2.8e-57 193.0 0.7 2.4 3 0 0 3 3 3 2 ZPR1 zinc-finger domain HypA PF01155.19 AMD18656.1 - 0.0017 18.4 4.7 0.57 10.2 0.9 2.5 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2294 PF10057.9 AMD18656.1 - 0.016 15.3 0.3 0.075 13.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2294) Cytochrom_C_2 PF01322.20 AMD18656.1 - 0.15 13.0 1.9 11 7.0 0.1 3.2 3 0 0 3 3 3 0 Cytochrome C' CIAPIN1 PF05093.13 AMD18656.1 - 0.84 10.2 4.7 7.9 7.1 1.1 2.9 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis zinc_ribbon_2 PF13240.6 AMD18656.1 - 1.3 8.9 13.5 5.9 6.7 0.6 3.9 4 0 0 4 4 4 0 zinc-ribbon domain UPF0547 PF10571.9 AMD18656.1 - 2.3 8.4 6.9 7.9 6.7 0.5 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 OrfB_Zn_ribbon PF07282.11 AMD18656.1 - 3 7.8 7.7 21 5.1 0.5 3.4 2 1 1 3 3 3 0 Putative transposase DNA-binding domain MMR_HSR1_C PF08438.10 AMD18657.1 - 5.6e-33 113.9 0.0 2.1e-32 112.0 0.0 1.9 2 0 0 2 2 2 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 AMD18657.1 - 9.7e-21 74.0 0.0 2.3e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD18657.1 - 3.2e-08 33.3 0.1 2.7e-06 27.0 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AMD18657.1 - 0.00078 19.5 0.1 0.0035 17.4 0.0 2.0 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 AMD18657.1 - 0.0013 18.3 0.1 0.25 10.9 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 AMD18657.1 - 0.0043 16.9 0.4 1.7 8.3 0.1 2.3 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein RHD3 PF05879.12 AMD18657.1 - 0.032 12.4 0.2 1.3 7.1 0.1 2.1 2 0 0 2 2 2 0 Root hair defective 3 GTP-binding protein (RHD3) RsgA_GTPase PF03193.16 AMD18657.1 - 0.033 14.1 0.1 9.3 6.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Ploopntkinase3 PF18751.1 AMD18657.1 - 0.038 13.9 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 RNA_helicase PF00910.22 AMD18657.1 - 0.046 14.1 0.0 15 6.0 0.0 2.4 2 0 0 2 2 2 0 RNA helicase cobW PF02492.19 AMD18657.1 - 0.051 13.2 0.3 7.6 6.1 0.0 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 AMD18657.1 - 0.1 11.9 0.0 2.3 7.5 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.27 AMD18657.1 - 0.12 12.9 0.0 0.4 11.2 0.0 1.8 2 0 0 2 2 2 0 ABC transporter KTI12 PF08433.10 AMD18657.1 - 0.14 11.6 0.2 0.36 10.2 0.0 1.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AA_permease PF00324.21 AMD18658.1 - 1.1e-114 383.7 44.5 1.3e-114 383.4 44.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD18658.1 - 2.2e-28 99.3 44.3 2.2e-28 99.3 44.3 1.9 1 1 1 2 2 2 1 Amino acid permease DUF2207 PF09972.9 AMD18658.1 - 9.6 4.8 0.0 9.6 4.8 0.0 3.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) TPP_enzyme_N PF02776.18 AMD18659.1 - 6.5e-32 110.5 0.0 1.1e-31 109.8 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AMD18659.1 - 8e-28 96.9 0.0 7.3e-27 93.8 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AMD18659.1 - 4.5e-14 52.5 0.0 7.4e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 AMD18659.1 - 0.095 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit RRM_1 PF00076.22 AMD18660.1 - 0.0001 22.1 0.0 0.0002 21.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HEAT PF02985.22 AMD18661.1 - 1.6e-05 24.7 0.0 0.47 10.8 0.0 4.8 4 0 0 4 4 3 1 HEAT repeat DUF641 PF04859.12 AMD18661.1 - 5.9e-05 23.4 6.4 0.00023 21.5 6.4 1.9 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) APG6_N PF17675.1 AMD18661.1 - 8.9e-05 23.0 5.8 8.9e-05 23.0 5.8 2.3 2 0 0 2 2 1 1 Apg6 coiled-coil region HEAT_2 PF13646.6 AMD18661.1 - 0.00012 22.4 0.2 3.6 8.0 0.0 5.0 3 1 2 5 5 5 1 HEAT repeats DUF3385 PF11865.8 AMD18661.1 - 0.00019 21.4 0.0 0.85 9.5 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF3385) HAUS-augmin3 PF14932.6 AMD18661.1 - 0.00095 18.8 8.4 0.0028 17.3 8.4 1.8 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.12 AMD18661.1 - 0.00098 19.2 7.6 0.00098 19.2 7.6 3.7 5 0 0 5 5 3 1 TPR/MLP1/MLP2-like protein TEX13 PF15186.6 AMD18661.1 - 0.0013 18.5 3.9 0.0025 17.5 1.9 2.5 2 0 0 2 2 2 1 Testis-expressed sequence 13 protein family SIKE PF05769.11 AMD18661.1 - 0.0018 18.2 3.2 0.0053 16.7 3.2 1.8 1 0 0 1 1 1 1 SIKE family CEP63 PF17045.5 AMD18661.1 - 0.0028 17.6 5.5 0.0074 16.2 5.5 1.6 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa Adaptin_N PF01602.20 AMD18661.1 - 0.0037 15.9 0.5 0.074 11.6 0.0 2.9 2 1 1 3 3 3 1 Adaptin N terminal region Bacillus_HBL PF05791.11 AMD18661.1 - 0.0054 16.6 9.0 0.25 11.1 7.0 2.9 2 0 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) Leu_zip PF15294.6 AMD18661.1 - 0.0091 15.5 5.6 0.023 14.2 5.6 1.6 1 0 0 1 1 1 1 Leucine zipper KASH_CCD PF14662.6 AMD18661.1 - 0.011 15.6 8.5 0.04 13.7 8.5 1.9 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH UPF0242 PF06785.11 AMD18661.1 - 0.012 15.7 7.1 0.033 14.3 7.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Tti2 PF10521.9 AMD18661.1 - 0.013 15.1 2.4 0.073 12.6 0.0 3.1 4 0 0 4 4 3 0 Tti2 family Spc7 PF08317.11 AMD18661.1 - 0.015 14.2 8.8 0.033 13.1 8.8 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein ADIP PF11559.8 AMD18661.1 - 0.017 15.2 12.2 0.07 13.2 12.2 2.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Myosin_tail_1 PF01576.19 AMD18661.1 - 0.026 12.4 7.4 0.038 11.8 7.4 1.1 1 0 0 1 1 1 0 Myosin tail FAM76 PF16046.5 AMD18661.1 - 0.047 13.1 8.3 0.16 11.3 8.3 2.0 1 0 0 1 1 1 0 FAM76 protein Golgin_A5 PF09787.9 AMD18661.1 - 0.09 12.2 10.9 0.052 13.0 8.4 1.8 2 0 0 2 2 1 0 Golgin subfamily A member 5 DUF3450 PF11932.8 AMD18661.1 - 0.21 10.9 14.5 0.039 13.2 10.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF812 PF05667.11 AMD18661.1 - 0.25 10.2 11.3 0.19 10.6 9.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF812) JIP_LZII PF16471.5 AMD18661.1 - 0.33 11.1 11.2 0.33 11.2 7.8 2.6 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II ATG16 PF08614.11 AMD18661.1 - 0.42 10.8 22.7 0.059 13.6 18.0 2.0 2 1 0 2 2 1 0 Autophagy protein 16 (ATG16) PI3K_P85_iSH2 PF16454.5 AMD18661.1 - 0.44 10.1 12.0 0.05 13.2 4.6 3.1 3 0 0 3 3 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Tropomyosin_1 PF12718.7 AMD18661.1 - 0.65 10.2 13.7 0.073 13.2 7.8 2.5 3 0 0 3 3 1 0 Tropomyosin like FapA PF03961.13 AMD18661.1 - 0.66 8.5 3.8 1.4 7.4 3.8 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A HMMR_C PF15908.5 AMD18661.1 - 0.79 10.0 8.7 1.2 9.4 5.4 2.9 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal MPS2 PF17060.5 AMD18661.1 - 0.88 8.8 5.4 1.8 7.8 5.4 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 YabA PF06156.13 AMD18661.1 - 0.98 10.1 8.1 6.5 7.5 8.1 2.5 1 0 0 1 1 1 0 Initiation control protein YabA DUF1828 PF08861.10 AMD18661.1 - 1.2 9.4 4.1 37 4.7 1.9 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF1828 SOGA PF11365.8 AMD18661.1 - 1.9 9.6 10.0 11 7.2 8.4 2.6 2 0 0 2 2 2 0 Protein SOGA Macoilin PF09726.9 AMD18661.1 - 2 6.9 15.4 0.097 11.2 10.1 1.5 2 0 0 2 2 2 0 Macoilin family OmpH PF03938.14 AMD18661.1 - 2.5 8.4 12.2 4.9 7.5 8.8 3.0 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.8 AMD18661.1 - 4.4 7.4 14.7 13 5.9 8.9 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 AMD18661.1 - 5.4 7.1 7.8 16 5.6 3.9 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) PCRF PF03462.18 AMD18661.1 - 5.5 6.8 11.3 1.1 9.1 5.9 2.5 2 1 0 2 2 2 0 PCRF domain AAA_23 PF13476.6 AMD18661.1 - 7.1 7.1 9.9 0.18 12.2 2.6 2.1 3 0 0 3 3 1 0 AAA domain CENP-F_leu_zip PF10473.9 AMD18661.1 - 9 6.3 16.7 84 3.2 0.0 3.2 3 1 0 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 AMD18661.1 - 9.7 6.5 11.3 9.6 6.5 7.5 3.0 2 1 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain Thioredoxin PF00085.20 AMD18662.1 - 2.9e-30 104.3 0.2 3.3e-30 104.1 0.2 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AMD18662.1 - 8e-06 26.3 0.3 0.00013 22.4 0.3 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AMD18662.1 - 0.00017 21.9 0.0 0.00021 21.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 AMD18662.1 - 0.0004 20.2 0.0 0.00046 20.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 AMD18662.1 - 0.0023 17.8 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AMD18662.1 - 0.0028 17.4 0.1 0.0058 16.4 0.0 1.6 1 1 1 2 2 2 1 Redoxin OST3_OST6 PF04756.13 AMD18662.1 - 0.015 14.6 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Phosducin PF02114.16 AMD18662.1 - 0.065 12.2 0.0 0.066 12.1 0.0 1.0 1 0 0 1 1 1 0 Phosducin Thioredoxin_7 PF13899.6 AMD18662.1 - 0.077 13.2 0.1 0.12 12.6 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like Glutaredoxin PF00462.24 AMD18662.1 - 0.1 12.8 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin Hydrolase PF00702.26 AMD18663.1 - 5.4e-17 62.8 1.7 1.1e-16 61.8 1.7 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AMD18663.1 - 4.3e-10 40.3 0.0 7.4e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AMD18663.1 - 8.2e-08 32.3 1.3 7.4e-07 29.2 0.0 2.6 1 1 2 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AMD18663.1 - 3e-06 27.4 1.3 0.015 15.4 0.4 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase RSS_P20 PF11757.8 AMD18663.1 - 0.031 14.7 0.5 0.085 13.3 0.2 1.9 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain LUC7 PF03194.15 AMD18663.1 - 0.11 12.2 0.4 0.13 11.9 0.4 1.3 1 0 0 1 1 1 0 LUC7 N_terminus Nt_Gln_amidase PF09764.9 AMD18663.1 - 0.15 11.7 0.7 0.22 11.1 0.7 1.2 1 0 0 1 1 1 0 N-terminal glutamine amidase ETF PF01012.21 AMD18664.1 - 1.5e-38 132.5 6.4 2.1e-38 132.0 6.4 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain DUF5594 PF18057.1 AMD18664.1 - 0.07 13.0 0.2 0.13 12.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5594) Mvb12 PF09452.10 AMD18665.1 - 8.5e-28 96.6 1.8 9.4e-28 96.5 1.8 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 DUF3584 PF12128.8 AMD18665.1 - 0.069 10.7 0.2 0.08 10.5 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) 3-HAO PF06052.12 AMD18666.1 - 1.8e-64 216.0 0.1 2.1e-64 215.8 0.1 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 AMD18666.1 - 2.8e-06 26.9 0.2 5e-06 26.1 0.2 1.4 1 0 0 1 1 1 1 Cupin domain Nudix_N_2 PF14803.6 AMD18666.1 - 0.017 15.0 1.0 2.3 8.2 0.4 2.6 2 0 0 2 2 2 0 Nudix N-terminal Cupin_1 PF00190.22 AMD18666.1 - 0.024 14.3 0.1 0.033 13.8 0.1 1.2 1 0 0 1 1 1 0 Cupin zf-B_box PF00643.24 AMD18666.1 - 0.027 14.6 3.4 0.057 13.6 0.6 2.3 2 0 0 2 2 2 0 B-box zinc finger AraC_binding PF02311.19 AMD18666.1 - 0.03 14.2 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain FYVE PF01363.21 AMD18666.1 - 0.076 13.2 1.0 0.14 12.3 1.0 1.3 1 0 0 1 1 1 0 FYVE zinc finger Aldolase_II PF00596.21 AMD18667.1 - 3.9e-45 154.1 0.0 4.7e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain LSM PF01423.22 AMD18668.1 - 2e-12 46.6 0.0 3.2e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 LSM domain Mer2 PF09074.10 AMD18669.1 - 1.4e-26 93.5 6.5 2.2e-26 92.9 6.5 1.3 1 0 0 1 1 1 1 Mer2 IFT57 PF10498.9 AMD18669.1 - 0.0068 15.4 2.5 0.019 14.0 0.4 2.0 2 0 0 2 2 2 1 Intra-flagellar transport protein 57 ATP-synt_ab_C PF00306.27 AMD18669.1 - 0.068 13.5 0.5 7.2 7.0 0.1 2.4 1 1 1 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain Baculo_PEP_C PF04513.12 AMD18669.1 - 0.069 13.2 2.4 0.23 11.5 1.7 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SlyX PF04102.12 AMD18669.1 - 0.11 13.1 2.1 8 7.2 0.9 2.8 2 1 0 2 2 2 0 SlyX Occludin_ELL PF07303.13 AMD18669.1 - 0.11 13.2 2.3 0.49 11.2 0.3 2.2 2 0 0 2 2 2 0 Occludin homology domain NUC130_3NT PF08158.12 AMD18669.1 - 0.16 12.3 2.5 0.3 11.4 0.1 2.4 3 0 0 3 3 3 0 NUC130/3NT domain KxDL PF10241.9 AMD18669.1 - 0.37 11.1 6.2 0.35 11.2 1.1 2.9 2 2 1 3 3 3 0 Uncharacterized conserved protein CdvA PF18822.1 AMD18669.1 - 1.3 8.9 7.9 0.66 9.8 0.3 3.1 2 2 1 3 3 3 0 CdvA-like coiled-coil domain AAA_16 PF13191.6 AMD18670.1 - 0.0023 18.3 0.0 0.0051 17.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 AMD18670.1 - 0.0037 17.3 0.0 0.029 14.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 AMD18670.1 - 0.011 16.1 0.0 0.026 14.9 0.0 1.6 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.12 AMD18670.1 - 0.02 14.2 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 AMD18670.1 - 0.037 14.3 0.0 0.12 12.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 AMD18670.1 - 0.12 11.9 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain FTHFS PF01268.19 AMD18671.1 - 1.1e-249 829.3 0.2 1.6e-249 828.7 0.2 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 AMD18671.1 - 9.1e-62 207.1 1.4 1.4e-61 206.5 0.3 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AMD18671.1 - 3.4e-37 127.3 0.8 7.8e-37 126.1 0.8 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain CbiA PF01656.23 AMD18671.1 - 0.069 13.2 0.0 0.34 11.0 0.0 2.2 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Rotamase PF00639.21 AMD18672.1 - 9.8e-23 80.9 0.1 1.3e-22 80.5 0.1 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 AMD18672.1 - 6.6e-18 65.3 0.0 8.5e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 AMD18672.1 - 1e-10 41.5 1.3 1.6e-10 40.8 1.3 1.3 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 AMD18672.1 - 1.2e-06 29.4 0.0 1.8e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Glyco_hyd_101C PF17451.2 AMD18672.1 - 0.023 15.0 0.3 0.042 14.1 0.3 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain Rhodanese PF00581.20 AMD18673.1 - 4.7e-13 49.6 0.0 5.3e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain FAST_1 PF06743.15 AMD18673.1 - 0.068 13.1 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 CTP_transf_like PF01467.26 AMD18674.1 - 3.1e-32 111.7 0.4 6.1e-32 110.8 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase-like CTNNBL PF08216.11 AMD18674.1 - 0.049 13.8 0.3 0.13 12.5 0.3 1.6 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear Trefoil PF00088.18 AMD18674.1 - 0.16 11.9 0.1 0.3 11.0 0.1 1.4 1 0 0 1 1 1 0 Trefoil (P-type) domain ILVD_EDD PF00920.21 AMD18675.1 - 1.3e-208 693.9 0.1 1.5e-208 693.7 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family WD40 PF00400.32 AMD18676.1 - 1.1e-30 105.2 24.5 6.5e-05 23.6 0.0 10.7 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD18676.1 - 6.4e-10 39.2 10.9 1.1 9.7 0.2 8.7 6 4 3 9 9 9 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 AMD18676.1 - 8.6e-06 25.8 0.2 0.0033 17.5 0.0 4.6 5 1 0 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 AMD18676.1 - 9e-06 24.9 1.2 0.057 12.4 0.1 4.3 4 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PMT PF02366.18 AMD18677.1 - 1.1e-84 283.8 19.7 1.1e-84 283.8 19.7 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AMD18677.1 - 2.1e-53 180.9 17.3 2.1e-53 180.9 17.3 2.3 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AMD18677.1 - 1.9e-14 54.0 0.0 3.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 MIR domain Lipase_3 PF01764.25 AMD18678.1 - 4.2e-30 104.5 0.0 6.4e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 AMD18678.1 - 0.00055 19.3 0.0 0.00075 18.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 AMD18678.1 - 0.017 14.7 0.1 4.5 6.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) zf-DNL PF05180.12 AMD18678.1 - 0.11 12.5 0.7 0.28 11.1 0.3 1.8 2 0 0 2 2 2 0 DNL zinc finger Abhydrolase_6 PF12697.7 AMD18678.1 - 0.17 12.5 0.1 0.23 12.0 0.1 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 AMD18679.1 - 2.2e-28 98.9 0.0 3.5e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 AMD18679.1 - 0.014 14.7 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 AMD18679.1 - 0.11 12.1 0.0 12 5.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Thioesterase PF00975.20 AMD18679.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain TPR_19 PF14559.6 AMD18680.1 - 0.0005 20.5 0.4 0.15 12.6 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AMD18680.1 - 0.68 10.3 3.8 27 5.3 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat SUI1 PF01253.22 AMD18681.1 - 4.2e-20 72.0 0.9 4.2e-20 72.0 0.9 1.7 2 0 0 2 2 2 1 Translation initiation factor SUI1 Img2 PF05046.14 AMD18681.1 - 0.63 10.4 2.5 3.6 8.0 2.5 2.2 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) OmpH PF03938.14 AMD18681.1 - 1.2 9.4 11.3 1.8 8.9 11.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Calcipressin PF04847.12 AMD18682.1 - 3.4e-14 53.0 0.2 4.3e-14 52.7 0.2 1.1 1 0 0 1 1 1 1 Calcipressin COX5A PF02284.16 AMD18683.1 - 5.1e-38 129.2 0.6 6.6e-38 128.9 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DUF4286 PF14114.6 AMD18683.1 - 0.024 15.1 0.1 4.9 7.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4286) DUF488 PF04343.13 AMD18683.1 - 0.031 14.9 0.2 0.23 12.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF488 Elf1 PF05129.13 AMD18684.1 - 7.3e-30 102.8 1.8 9.4e-30 102.5 1.8 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like BrnA_antitoxin PF14384.6 AMD18684.1 - 0.059 13.9 0.1 16 6.1 0.0 2.6 2 0 0 2 2 2 0 BrnA antitoxin of type II toxin-antitoxin system CDC45 PF02724.14 AMD18684.1 - 0.13 10.5 3.0 0.13 10.5 3.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L37ae PF01780.19 AMD18684.1 - 0.26 11.4 1.1 0.51 10.5 1.1 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family Ribosomal_L1 PF00687.21 AMD18685.1 - 6.5e-39 133.8 4.5 8.3e-39 133.4 3.9 1.6 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family GCR1_C PF12550.8 AMD18686.1 - 1.5e-12 47.7 0.4 2.8e-12 46.8 0.4 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Androgen_recep PF02166.16 AMD18686.1 - 0.035 13.0 1.2 0.046 12.6 1.2 1.3 1 0 0 1 1 1 0 Androgen receptor Vezatin PF12632.7 AMD18686.1 - 0.039 13.3 0.9 0.064 12.6 0.9 1.3 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes SelP_N PF04592.14 AMD18686.1 - 0.051 13.0 8.6 0.095 12.1 8.6 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ALF PF03752.13 AMD18686.1 - 0.14 12.2 0.2 0.29 11.1 0.2 1.5 1 0 0 1 1 1 0 Short repeats of unknown function CPSF73-100_C PF11718.8 AMD18686.1 - 0.14 11.7 2.4 0.32 10.5 1.6 2.0 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term MatE PF01554.18 AMD18687.1 - 8.2e-65 217.4 40.6 1.5e-38 132.0 12.1 2.6 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 AMD18687.1 - 0.2 11.7 44.6 0.094 12.8 6.5 4.4 2 2 1 3 3 3 0 Polysaccharide biosynthesis C-terminal domain PIF1 PF05970.14 AMD18688.1 - 1.1e-52 179.5 0.0 7.8e-41 140.4 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 AMD18688.1 - 2.2e-21 76.5 0.0 3.9e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD18688.1 - 8.3e-08 32.7 0.0 2.6e-07 31.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 AMD18688.1 - 4.5e-06 24.9 0.6 4.1e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.6 AMD18688.1 - 5.2e-06 26.8 0.0 4e-05 23.9 0.0 2.5 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 AMD18688.1 - 3.6e-05 23.6 0.0 0.013 15.3 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.18 AMD18688.1 - 0.00077 18.9 0.1 0.0014 18.0 0.1 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.6 AMD18688.1 - 0.00091 19.7 0.1 0.0036 17.7 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 AMD18688.1 - 0.001 18.6 0.0 0.0024 17.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 AMD18688.1 - 0.0048 16.0 0.0 0.0096 15.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 AMD18688.1 - 0.01 15.1 0.0 0.071 12.3 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 AMD18688.1 - 0.015 15.8 0.0 0.031 14.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 AMD18688.1 - 0.016 15.0 0.3 0.075 12.9 0.3 2.1 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain TrwB_AAD_bind PF10412.9 AMD18688.1 - 0.031 13.2 0.0 0.049 12.5 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.12 AMD18688.1 - 0.053 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 AMD18688.1 - 0.062 13.3 0.0 0.49 10.4 0.0 2.4 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 AMD18688.1 - 0.069 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 AMD18688.1 - 0.09 12.0 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 AMD18688.1 - 0.1 13.0 0.0 0.5 10.8 0.0 2.2 2 1 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 AMD18688.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 AMD18688.1 - 0.14 12.0 0.1 1 9.2 0.1 2.1 1 1 0 1 1 1 0 Helicase ABC_tran PF00005.27 AMD18688.1 - 0.19 12.3 0.4 0.73 10.3 0.1 2.1 2 0 0 2 2 2 0 ABC transporter Pkinase PF00069.25 AMD18689.1 - 2e-62 211.0 0.0 2.7e-62 210.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18689.1 - 4.5e-31 108.1 0.0 7.3e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD18689.1 - 0.0043 16.1 0.1 0.011 14.7 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AMD18689.1 - 0.076 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 AMD18689.1 - 0.14 13.1 0.0 0.55 11.2 0.0 2.1 1 0 0 1 1 1 0 WD domain, G-beta repeat RolB_RolC PF02027.17 AMD18689.1 - 0.16 11.7 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 RolB/RolC glucosidase family RasGEF PF00617.19 AMD18691.1 - 4.4e-43 147.5 3.4 7.6e-41 140.2 1.2 2.5 2 0 0 2 2 2 2 RasGEF domain RasGEF_N PF00618.20 AMD18691.1 - 2.2e-12 47.1 1.3 6.4e-12 45.6 0.4 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif Sugarporin_N PF11471.8 AMD18691.1 - 0.12 12.3 0.8 0.33 10.9 0.8 1.7 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension LDB19 PF13002.7 AMD18692.1 - 9e-68 227.8 0.0 1.4e-67 227.2 0.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 AMD18692.1 - 0.027 14.5 0.0 0.073 13.1 0.0 1.7 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain DUF2981 PF11200.8 AMD18692.1 - 0.36 10.5 1.7 0.59 9.8 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) PMT PF02366.18 AMD18693.1 - 2.3e-94 315.6 14.3 2.3e-94 315.6 14.3 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AMD18693.1 - 1.9e-62 210.4 12.7 1.9e-62 210.4 12.7 2.5 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AMD18693.1 - 4e-24 85.5 0.8 6.4e-24 84.8 0.8 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 AMD18693.1 - 5.3e-06 26.7 8.2 5.3e-06 26.7 8.2 2.8 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Nucleoside_tran PF01733.18 AMD18694.1 - 2.5e-26 92.8 14.2 1.1e-25 90.7 14.2 2.0 1 1 0 1 1 1 1 Nucleoside transporter XPG_N PF00752.17 AMD18695.1 - 1.1e-35 122.1 0.0 2.5e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AMD18695.1 - 6.4e-28 97.0 0.2 1.6e-27 95.6 0.0 1.8 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 AMD18695.1 - 7.1e-05 23.3 2.3 0.00024 21.6 0.0 2.6 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 AMD18695.1 - 0.14 12.2 0.0 0.53 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif AP_endonuc_2 PF01261.24 AMD18697.1 - 1.5e-31 109.5 0.0 2.3e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Pkinase PF00069.25 AMD18698.1 - 5.9e-38 130.7 0.0 9.7e-38 130.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18698.1 - 3e-20 72.6 0.0 1.3e-19 70.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Aldose_epim PF01263.20 AMD18699.1 - 1.4e-46 159.2 0.3 1.7e-46 158.9 0.3 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase DUF3699 PF12480.8 AMD18700.1 - 0.095 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3699) Sporozoite_P67 PF05642.11 AMD18700.1 - 0.1 10.7 2.3 0.12 10.4 2.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-RING_2 PF13639.6 AMD18701.1 - 4.3e-06 27.0 9.9 9.3e-06 25.9 9.9 1.6 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 AMD18701.1 - 1.6e-05 25.0 5.5 3.7e-05 23.8 5.5 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 AMD18701.1 - 0.00039 20.6 9.1 0.00097 19.4 9.1 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AMD18701.1 - 0.0019 18.2 2.6 0.0041 17.1 2.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 AMD18701.1 - 0.11 12.6 8.2 0.22 11.7 8.2 1.5 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4 PF00097.25 AMD18701.1 - 0.85 9.5 12.1 1.2 9.1 10.9 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD18701.1 - 1.2 9.1 6.5 31 4.5 6.5 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 AMD18701.1 - 1.4 9.3 12.0 0.79 10.1 9.6 1.9 2 0 0 2 2 2 0 RING-like domain Zn_ribbon_17 PF17120.5 AMD18701.1 - 1.9 8.1 9.7 0.47 10.1 6.0 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 AMD18701.1 - 4.1 7.3 11.0 6.1 6.8 9.8 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Mannosyl_trans3 PF11051.8 AMD18702.1 - 0.0008 18.8 1.3 0.0019 17.6 1.3 1.7 1 1 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 AMD18702.1 - 0.0012 18.5 4.9 0.0033 17.0 1.5 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 8 3HCDH_N PF02737.18 AMD18702.1 - 0.0012 18.7 0.1 0.018 14.9 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RRM_1 PF00076.22 AMD18703.1 - 4.4e-28 96.9 0.5 4.9e-15 55.1 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AMD18703.1 - 1e-05 25.1 0.3 9.8e-05 21.9 0.0 2.1 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD18703.1 - 0.0036 17.4 0.1 0.073 13.2 0.0 2.3 2 1 0 2 2 2 1 RNA recognition motif SAM_decarbox PF01536.16 AMD18704.1 - 7.4e-124 413.3 4.5 8.9e-124 413.1 4.5 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase FAM199X PF15814.5 AMD18704.1 - 0.081 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein family FAM199X Recep_L_domain PF01030.24 AMD18706.1 - 5.2e-09 36.2 9.6 0.0016 18.5 0.4 4.7 1 1 4 5 5 5 4 Receptor L domain LRR_9 PF14580.6 AMD18706.1 - 0.022 14.3 0.4 0.022 14.3 0.4 2.1 2 0 0 2 2 2 0 Leucine-rich repeat YceI PF04264.13 AMD18706.1 - 0.038 14.5 1.1 0.43 11.1 0.0 2.3 2 0 0 2 2 2 0 YceI-like domain LRR_5 PF13306.6 AMD18706.1 - 0.09 12.7 2.6 0.47 10.4 0.6 2.6 2 2 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) Secretin_N_2 PF07655.13 AMD18706.1 - 1.3 9.6 16.0 1.1 9.8 10.5 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain LRR_8 PF13855.6 AMD18706.1 - 8.2 6.3 11.1 3.4 7.5 0.3 4.3 4 0 0 4 4 4 0 Leucine rich repeat GLTP PF08718.11 AMD18707.1 - 9.1e-41 139.6 0.1 2e-40 138.5 0.0 1.5 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) DUF2451 PF10474.9 AMD18707.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) PCI PF01399.27 AMD18708.1 - 1.5e-05 25.4 0.2 0.00024 21.6 0.0 2.8 2 0 0 2 2 2 1 PCI domain DUF2064 PF09837.9 AMD18708.1 - 0.05 13.4 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) AAA PF00004.29 AMD18709.1 - 1.4e-51 174.4 0.0 1.6e-38 132.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 AMD18709.1 - 3.8e-12 45.8 3.6 1.8e-11 43.7 0.5 3.0 3 0 0 3 3 3 1 Cell division protein 48 (CDC48), domain 2 AAA_lid_3 PF17862.1 AMD18709.1 - 5.2e-10 39.0 0.1 1.5e-09 37.5 0.1 1.9 1 1 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AMD18709.1 - 4.1e-09 37.0 0.1 0.002 18.5 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 AMD18709.1 - 8.6e-09 35.8 0.6 0.00045 20.5 0.1 3.3 2 2 0 3 3 2 2 AAA domain TIP49 PF06068.13 AMD18709.1 - 1.2e-07 31.3 0.4 0.0082 15.4 0.0 2.5 2 1 1 3 3 3 2 TIP49 P-loop domain Mg_chelatase PF01078.21 AMD18709.1 - 1.6e-06 27.6 0.2 0.0019 17.6 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 AMD18709.1 - 5.4e-06 26.2 0.1 0.068 12.9 0.1 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 AMD18709.1 - 7.1e-06 25.9 0.0 0.091 12.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AMD18709.1 - 8e-06 25.9 2.5 0.04 13.8 0.1 3.7 4 0 0 4 4 3 2 NACHT domain AAA_5 PF07728.14 AMD18709.1 - 9e-06 25.7 0.0 0.0037 17.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) PhoH PF02562.16 AMD18709.1 - 2.4e-05 23.9 0.0 0.029 13.8 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_33 PF13671.6 AMD18709.1 - 3.7e-05 23.9 0.0 0.39 10.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AMD18709.1 - 4e-05 23.4 0.0 0.25 11.1 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_2 PF07724.14 AMD18709.1 - 4.1e-05 23.7 0.0 0.0021 18.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 AMD18709.1 - 6.4e-05 23.3 0.0 0.12 12.8 0.0 3.1 2 0 0 2 2 2 1 RNA helicase TsaE PF02367.17 AMD18709.1 - 9e-05 22.5 0.0 0.55 10.2 0.0 3.0 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 AMD18709.1 - 0.00011 22.7 0.5 0.03 14.8 0.1 2.6 2 0 0 2 2 2 1 ABC transporter NB-ARC PF00931.22 AMD18709.1 - 0.0002 20.7 0.1 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_18 PF13238.6 AMD18709.1 - 0.00027 21.5 0.0 0.3 11.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain Sigma54_activat PF00158.26 AMD18709.1 - 0.0003 20.5 0.0 0.85 9.3 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain DUF2075 PF09848.9 AMD18709.1 - 0.00031 20.1 0.0 0.52 9.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 AMD18709.1 - 0.0005 19.8 0.0 0.8 9.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 AMD18709.1 - 0.00054 20.1 0.0 0.0033 17.5 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain ResIII PF04851.15 AMD18709.1 - 0.00069 19.7 0.0 0.68 9.9 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 AMD18709.1 - 0.00075 19.1 0.1 0.078 12.5 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_14 PF13173.6 AMD18709.1 - 0.0011 19.0 0.0 2.5 8.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 AMD18709.1 - 0.0025 18.4 1.6 3 8.3 0.4 2.7 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 AMD18709.1 - 0.0046 17.3 0.0 1 9.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain TniB PF05621.11 AMD18709.1 - 0.0052 16.2 0.1 3.9 6.8 0.1 3.1 2 1 0 2 2 2 1 Bacterial TniB protein ATPase PF06745.13 AMD18709.1 - 0.0069 15.7 0.8 0.3 10.4 0.1 2.8 3 0 0 3 3 3 1 KaiC Parvo_NS1 PF01057.17 AMD18709.1 - 0.0077 15.4 0.0 3.1 6.8 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 AMD18709.1 - 0.0079 16.0 0.0 0.52 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 AMD18709.1 - 0.0083 15.7 0.7 4.6 6.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 AMD18709.1 - 0.011 15.7 0.2 5.4 6.9 0.0 3.1 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 AMD18709.1 - 0.024 13.7 0.0 3 6.8 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Bac_DnaA PF00308.18 AMD18709.1 - 0.025 14.4 0.0 8.5 6.1 0.0 2.9 3 0 0 3 3 2 0 Bacterial dnaA protein DEAD PF00270.29 AMD18709.1 - 0.026 14.3 0.3 27 4.5 0.0 3.9 3 1 1 4 4 4 0 DEAD/DEAH box helicase AAA_28 PF13521.6 AMD18709.1 - 0.028 14.7 0.0 6.4 7.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 AMD18709.1 - 0.04 14.4 0.0 9.9 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 AMD18709.1 - 0.041 13.8 0.0 0.26 11.2 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IPT PF01745.16 AMD18709.1 - 0.061 12.7 0.2 0.48 9.8 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase AAA_29 PF13555.6 AMD18709.1 - 0.081 12.7 0.5 4.8 7.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Cytidylate_kin PF02224.18 AMD18709.1 - 0.085 12.6 0.2 4.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase Vps4_C PF09336.10 AMD18709.1 - 0.14 12.1 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Chordopox_L2 PF05803.12 AMD18710.1 - 0.17 11.7 0.1 0.42 10.5 0.1 1.6 1 0 0 1 1 1 0 Chordopoxvirus L2 protein Yos9_DD PF17880.1 AMD18711.1 - 2.1e-17 63.4 0.1 3.8e-17 62.6 0.1 1.4 1 0 0 1 1 1 1 Yos9 dimerzation domain NifT PF06988.11 AMD18711.1 - 0.15 11.9 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 NifT/FixU protein Bromodomain PF00439.25 AMD18712.1 - 3.8e-16 58.9 3.3 4.4e-16 58.7 1.1 2.3 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.13 AMD18712.1 - 1.1e-05 25.3 0.0 0.00013 21.9 0.0 2.6 3 0 0 3 3 3 1 Bromodomain associated UQ_con PF00179.26 AMD18713.1 - 3.2e-52 175.9 0.0 3.6e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 AMD18713.1 - 0.001 19.3 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 AMD18713.1 - 0.0046 16.7 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 AMD18713.1 - 0.018 14.9 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain CBF PF03914.17 AMD18714.1 - 7.2e-48 162.8 0.7 7.2e-48 162.8 0.7 3.0 3 0 0 3 3 3 1 CBF/Mak21 family Ribosomal_L19e PF01280.20 AMD18714.1 - 4.2 7.4 7.9 0.56 10.3 1.2 2.4 2 0 0 2 2 2 0 Ribosomal protein L19e TEA PF01285.18 AMD18715.1 - 6.4e-25 87.0 0.2 1.8e-24 85.6 0.2 1.9 1 0 0 1 1 1 1 TEA/ATTS domain SesA PF17107.5 AMD18715.1 - 0.73 10.0 4.7 0.78 9.9 0.4 2.4 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases FTHFS PF01268.19 AMD18716.1 - 8.1e-252 836.3 2.1 1e-251 836.0 2.1 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 AMD18716.1 - 3.8e-66 221.3 1.4 3.8e-66 221.3 1.4 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AMD18716.1 - 3.3e-36 124.1 0.2 7.8e-36 122.9 0.2 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain PBP-Tp47_a PF14889.6 AMD18716.1 - 0.058 13.0 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a Ribosomal_L19e PF01280.20 AMD18717.1 - 3.9e-56 189.1 11.2 3.9e-56 189.1 11.2 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e TilS PF09179.11 AMD18717.1 - 0.36 11.3 7.6 14 6.3 5.7 3.0 2 1 0 2 2 2 0 TilS substrate binding domain DUF2423 PF10338.9 AMD18718.1 - 5.4e-18 64.9 6.7 5.4e-18 64.9 6.7 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) DUF4632 PF15451.6 AMD18718.1 - 0.025 14.6 0.7 0.033 14.2 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) DUF444 PF04285.12 AMD18718.1 - 0.19 10.8 5.3 0.22 10.6 5.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF444) Apt1 PF10351.9 AMD18719.1 - 0.18 10.6 2.5 0.24 10.2 2.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM199X PF15814.5 AMD18719.1 - 3 6.8 15.1 0.099 11.7 9.1 1.5 2 0 0 2 2 2 0 Protein family FAM199X zinc_ribbon_15 PF17032.5 AMD18720.1 - 0.0017 19.0 0.5 0.0023 18.7 0.5 1.2 1 0 0 1 1 1 1 zinc-ribbon family Zn_Tnp_IS1595 PF12760.7 AMD18720.1 - 0.44 10.6 5.9 2.5 8.1 0.1 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Fungal_trans PF04082.18 AMD18721.1 - 1.4e-15 57.1 0.1 2.5e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD18721.1 - 6.7e-09 35.7 14.0 1.2e-08 34.9 14.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.27 AMD18722.1 - 4.2e-64 212.5 5.9 2.7e-23 81.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 AMD18722.1 - 0.0021 17.3 0.1 0.056 12.6 0.0 2.1 2 0 0 2 2 2 2 Fuseless CytB6-F_Fe-S PF08802.10 AMD18722.1 - 0.048 13.7 1.1 13 5.9 0.1 3.0 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Msap1 PF17077.5 AMD18723.1 - 1.7e-26 93.2 20.0 1.4e-24 86.9 15.0 3.1 2 1 0 2 2 2 2 Mitotic spindle associated protein SHE1 DUF5314 PF17241.2 AMD18723.1 - 0.18 11.4 0.2 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5314) KH_1 PF00013.29 AMD18724.1 - 1.3e-35 121.0 7.7 1.6e-14 53.5 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 AMD18724.1 - 7.2e-09 35.4 1.8 0.056 13.3 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 AMD18724.1 - 0.02 14.8 2.0 2.7 7.9 0.0 3.5 3 1 0 3 3 3 0 KH domain KH_5 PF13184.6 AMD18724.1 - 0.031 14.3 2.3 11 6.1 0.0 3.3 3 0 0 3 3 3 0 NusA-like KH domain GTP_cyclohydro2 PF00925.20 AMD18725.1 - 9.5e-57 191.1 0.0 1.7e-56 190.3 0.0 1.4 1 1 0 1 1 1 1 GTP cyclohydrolase II CLASP_N PF12348.8 AMD18727.1 - 9e-72 241.3 10.5 8.7e-68 228.3 2.9 2.6 2 0 0 2 2 2 2 CLASP N terminal RIH_assoc PF08454.11 AMD18727.1 - 0.22 11.4 2.4 7.2 6.5 0.1 3.2 2 0 0 2 2 2 0 RyR and IP3R Homology associated CCDC24 PF15669.5 AMD18727.1 - 0.23 11.3 5.1 0.25 11.2 0.1 2.9 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 24 family Pol_alpha_B_N PF08418.10 AMD18728.1 - 6.3e-59 199.9 0.3 9.5e-59 199.3 0.3 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 AMD18728.1 - 1e-43 149.2 0.4 1.5e-43 148.6 0.4 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Anoctamin PF04547.12 AMD18729.1 - 6.9e-41 140.5 25.6 4.7e-40 137.8 25.6 1.9 1 1 0 1 1 1 1 Calcium-activated chloride channel Ala_racemase_N PF01168.20 AMD18730.1 - 3.4e-24 85.7 0.0 4.3e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Adaptin_N PF01602.20 AMD18731.1 - 5.7e-67 226.5 12.4 7.4e-67 226.1 12.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 AMD18731.1 - 0.00086 19.5 0.0 0.0023 18.1 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 AMD18731.1 - 0.0025 18.1 0.0 0.008 16.5 0.0 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain DNA_pol3_delta2 PF13177.6 AMD18732.1 - 5.3e-11 42.6 1.5 2.9e-10 40.2 1.5 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 AMD18732.1 - 6.8e-05 23.3 0.3 0.00016 22.1 0.3 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 AMD18732.1 - 0.0086 16.4 0.1 0.2 12.0 0.1 2.4 2 0 0 2 2 2 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 AMD18732.1 - 0.029 14.1 0.1 0.057 13.2 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Ribosomal_L16 PF00252.18 AMD18733.1 - 8e-37 126.2 0.5 1e-36 125.9 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA-synt_2d PF01409.20 AMD18734.1 - 1.2e-44 152.7 0.3 7.8e-26 91.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 AMD18734.1 - 5.8e-26 90.7 0.1 1.8e-25 89.2 0.1 1.9 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Phage_connector PF05352.12 AMD18734.1 - 0.013 15.0 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Phage Connector (GP10) DUF3811 PF11656.8 AMD18734.1 - 0.062 13.7 0.1 0.17 12.3 0.1 1.7 1 0 0 1 1 1 0 YjbD family (DUF3811) FAD_binding_1 PF00667.20 AMD18735.1 - 1.4e-26 93.4 0.0 2.5e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 AMD18735.1 - 1.7e-19 70.4 0.0 4.8e-19 69.0 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 AMD18735.1 - 4.2e-14 53.1 0.0 8.3e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain IgGFc_binding PF17517.2 AMD18735.1 - 0.083 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 IgGFc binding protein ATG11 PF10377.9 AMD18736.1 - 7.9e-39 132.7 1.5 2.2e-38 131.2 0.0 2.6 2 0 0 2 2 2 1 Autophagy-related protein 11 REV1_C PF16727.5 AMD18736.1 - 0.04 14.3 0.0 0.26 11.7 0.0 2.4 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain HycH PF07450.11 AMD18736.1 - 1.3 9.5 5.6 1.6 9.1 0.2 3.7 3 0 0 3 3 3 0 Formate hydrogenlyase maturation protein HycH HALZ PF02183.18 AMD18736.1 - 2.4 8.4 9.7 0.84 9.9 2.0 3.8 2 1 1 3 3 3 0 Homeobox associated leucine zipper NYD-SP28_assoc PF14775.6 AMD18736.1 - 8 6.7 9.4 19 5.5 2.2 4.0 3 0 0 3 3 3 0 Sperm tail C-terminal domain Acetyltransf_1 PF00583.25 AMD18737.1 - 4.3e-16 59.2 0.0 5.5e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AMD18737.1 - 3e-11 43.6 0.0 4.1e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AMD18737.1 - 4.7e-11 42.7 0.0 6.7e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AMD18737.1 - 7.9e-08 32.2 0.1 1.2e-07 31.6 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 AMD18737.1 - 0.0011 18.6 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 AMD18737.1 - 0.0065 16.0 0.2 0.014 14.9 0.2 1.7 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_13 PF13880.6 AMD18737.1 - 0.016 15.2 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_9 PF13527.7 AMD18737.1 - 0.017 15.2 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 AMD18737.1 - 0.025 14.2 0.1 0.026 14.1 0.1 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Acetyltransf_3 PF13302.7 AMD18737.1 - 0.064 13.9 0.0 0.076 13.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AMD18737.1 - 0.074 13.2 0.0 0.076 13.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AMD18737.1 - 0.086 13.0 0.0 0.14 12.4 0.0 1.5 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase PCNA_N PF00705.18 AMD18738.1 - 4.8e-51 171.8 1.9 9.7e-51 170.8 1.1 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 AMD18738.1 - 3.7e-48 162.9 0.3 7.9e-47 158.6 0.1 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 AMD18738.1 - 6.5e-07 28.7 0.4 8.4e-06 25.0 0.4 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 AMD18738.1 - 0.00045 19.7 0.0 0.00055 19.5 0.0 1.1 1 0 0 1 1 1 1 Rad9 FOP_dimer PF09398.10 AMD18738.1 - 0.1 12.9 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 FOP N terminal dimerisation domain LmjF365940-deam PF14421.6 AMD18738.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases HMG_box PF00505.19 AMD18739.1 - 1.2e-26 92.9 1.8 1.2e-26 92.9 1.8 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AMD18739.1 - 1.6e-19 70.3 2.3 1.6e-19 70.3 2.3 1.4 2 0 0 2 2 2 1 HMG-box domain Ccdc124 PF06244.12 AMD18739.1 - 0.0006 20.4 0.1 0.0006 20.4 0.1 1.9 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box_5 PF14887.6 AMD18739.1 - 0.05 13.6 0.6 0.05 13.6 0.6 2.0 2 1 0 2 2 2 0 HMG (high mobility group) box 5 YABBY PF04690.13 AMD18739.1 - 0.068 13.7 0.6 0.068 13.7 0.6 1.5 1 1 1 2 2 2 0 YABBY protein CHDNT PF08073.12 AMD18739.1 - 0.071 13.1 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 CHDNT (NUC034) domain zf-Tim10_DDP PF02953.15 AMD18740.1 - 6.5e-15 54.5 0.4 9.3e-15 54.0 0.1 1.4 2 0 0 2 2 2 1 Tim10/DDP family zinc finger TTL PF03133.15 AMD18741.1 - 7.8e-72 241.9 4.1 1.2e-71 241.2 4.1 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 AMD18741.1 - 2.6e-17 63.2 0.0 5.2e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 AMD18741.1 - 2.2e-07 30.4 0.0 0.0023 17.2 0.0 2.2 2 0 0 2 2 2 2 YheC/D like ATP-grasp RXT2_N PF08595.11 AMD18742.1 - 1e-37 129.6 0.7 1e-37 129.6 0.7 2.6 3 0 0 3 3 3 1 RXT2-like, N-terminal Phlebovirus_NSM PF07246.11 AMD18742.1 - 0.0013 18.1 0.5 0.0026 17.2 0.5 1.4 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M YbfN PF13982.6 AMD18742.1 - 0.074 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 YbfN-like lipoprotein 4HBT_2 PF13279.6 AMD18743.1 - 3.9e-09 37.0 0.1 5.5e-09 36.6 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Pkinase PF00069.25 AMD18744.1 - 5.1e-62 209.6 0.0 6.5e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18744.1 - 1.8e-29 102.8 0.0 2.5e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD18744.1 - 0.002 17.1 0.1 0.0032 16.5 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AMD18744.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.25 AMD18745.1 - 2.7e-26 92.5 0.2 6.9e-26 91.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain HEAT PF02985.22 AMD18745.1 - 3.7e-12 45.4 3.2 0.24 11.7 0.0 5.9 5 0 0 5 5 5 3 HEAT repeat Pkinase_Tyr PF07714.17 AMD18745.1 - 9.3e-11 41.5 0.0 2e-10 40.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 AMD18745.1 - 8.5e-07 29.3 0.0 0.024 15.0 0.0 3.4 2 1 1 3 3 3 2 HEAT repeats WD40 PF00400.32 AMD18745.1 - 3.4e-05 24.5 1.3 8.2 7.5 0.0 5.0 5 0 0 5 5 4 2 WD domain, G-beta repeat Kinase-like PF14531.6 AMD18745.1 - 3.4e-05 23.3 0.0 6.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Cnd1 PF12717.7 AMD18745.1 - 5.7e-05 23.2 4.2 0.1 12.7 1.0 3.6 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 AMD18745.1 - 0.022 15.3 0.3 3.5 8.2 0.0 3.7 4 0 0 4 4 4 0 HEAT-like repeat APH PF01636.23 AMD18745.1 - 0.045 13.7 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RTP1_C1 PF10363.9 AMD18745.1 - 0.23 11.6 1.2 3.3 7.9 0.2 2.6 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.6 AMD18745.1 - 0.36 11.2 2.1 19 5.7 0.0 3.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Sec8_exocyst PF04048.14 AMD18746.1 - 3.3e-48 163.2 6.2 3.3e-47 159.9 2.9 3.2 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain DUF2451 PF10474.9 AMD18746.1 - 5.8e-13 49.2 2.0 2.7e-10 40.4 0.3 3.0 2 0 0 2 2 2 2 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 AMD18746.1 - 3.8e-05 23.1 2.2 0.00019 20.8 1.9 2.4 1 1 1 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Sec5 PF15469.6 AMD18746.1 - 0.00027 20.8 5.1 0.00027 20.8 5.1 3.8 3 1 0 3 3 3 1 Exocyst complex component Sec5 Apolipoprotein PF01442.18 AMD18746.1 - 0.0012 18.8 0.2 0.52 10.2 0.1 3.8 3 1 0 3 3 3 1 Apolipoprotein A1/A4/E domain COG2 PF06148.11 AMD18746.1 - 0.031 14.4 4.7 0.093 12.8 1.0 3.5 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ApoLp-III PF07464.11 AMD18746.1 - 0.81 9.8 11.9 0.68 10.0 1.0 4.8 5 1 0 5 5 5 0 Apolipophorin-III precursor (apoLp-III) BLOC1S3 PF15753.5 AMD18746.1 - 0.96 9.6 6.5 0.9 9.6 0.6 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF2730 PF10805.8 AMD18746.1 - 2 8.6 7.2 19 5.4 0.8 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF2730) DUF948 PF06103.11 AMD18746.1 - 5 7.5 6.9 6.8 7.0 1.4 3.9 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Phage_GP20 PF06810.11 AMD18746.1 - 5 6.9 9.5 0.55 10.0 0.6 3.7 3 1 1 4 4 4 0 Phage minor structural protein GP20 Mce4_CUP1 PF11887.8 AMD18746.1 - 5.3 6.4 7.4 3.3 7.1 0.8 3.0 2 1 1 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative KxDL PF10241.9 AMD18746.1 - 9.8 6.5 8.3 10 6.5 0.4 4.6 4 1 0 4 4 4 0 Uncharacterized conserved protein ERCC4 PF02732.15 AMD18747.1 - 1.3e-11 45.0 0.4 4e-11 43.4 0.4 1.9 1 0 0 1 1 1 1 ERCC4 domain ATP-synt_F PF01990.17 AMD18747.1 - 0.058 13.7 0.0 0.24 11.7 0.0 2.1 2 0 0 2 2 2 0 ATP synthase (F/14-kDa) subunit 5_3_exonuc PF01367.20 AMD18747.1 - 0.16 12.6 0.8 0.69 10.6 0.3 2.4 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold Fes1 PF08609.10 AMD18748.1 - 4e-22 78.9 0.5 4e-22 78.9 0.5 2.5 3 0 0 3 3 3 1 Nucleotide exchange factor Fes1 Rcd1 PF04078.13 AMD18748.1 - 0.011 15.1 0.3 1.6 7.9 0.0 2.3 1 1 1 2 2 2 0 Cell differentiation family, Rcd1-like FPL PF09758.9 AMD18748.1 - 0.042 13.9 7.0 5.1 7.1 0.3 3.5 2 1 2 4 4 4 0 Uncharacterised conserved protein HEAT_EZ PF13513.6 AMD18748.1 - 0.11 13.0 0.0 1.6 9.3 0.0 2.7 1 1 1 2 2 2 0 HEAT-like repeat Arm PF00514.23 AMD18748.1 - 0.28 11.3 1.6 13 6.0 0.0 4.1 5 1 0 5 5 5 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 AMD18748.1 - 0.44 10.6 3.5 0.34 11.0 0.1 2.3 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain UFD1 PF03152.14 AMD18749.1 - 1.6e-07 30.9 0.1 0.00097 18.7 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 AMD18749.1 - 7.1e-06 26.2 0.3 7.1e-06 26.2 0.3 3.0 5 0 0 5 5 5 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A zf_UBZ PF18439.1 AMD18749.1 - 0.019 14.6 11.4 1.3 8.6 0.1 4.5 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf_C2H2_13 PF18508.1 AMD18749.1 - 1.9 8.2 10.9 1 9.0 0.3 4.0 3 0 0 3 3 3 0 Zinc finger domain Exo84_C PF16528.5 AMD18750.1 - 1.6e-58 197.9 2.7 1.6e-58 197.9 2.7 2.3 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 AMD18750.1 - 5.6e-09 36.0 3.1 5.6e-09 36.0 3.1 2.5 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 AMD18750.1 - 0.0071 16.4 1.0 0.0071 16.4 1.0 2.7 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 L27 PF02828.16 AMD18750.1 - 0.0092 15.7 0.0 0.073 12.8 0.0 2.5 3 0 0 3 3 3 1 L27 domain PP1_inhibitor PF05361.12 AMD18750.1 - 0.32 11.0 3.7 0.6 10.1 0.2 3.1 4 0 0 4 4 4 0 PKC-activated protein phosphatase-1 inhibitor SKA2 PF16740.5 AMD18750.1 - 0.36 10.6 7.4 0.4 10.5 2.9 2.9 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 KELK PF15796.5 AMD18750.1 - 1.8 9.1 7.1 3.4 8.2 1.8 3.4 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase APG6_N PF17675.1 AMD18750.1 - 2.2 8.8 9.9 4.4 7.8 5.5 2.6 2 0 0 2 2 2 0 Apg6 coiled-coil region Occludin_ELL PF07303.13 AMD18750.1 - 2.8 8.7 11.2 4.2 8.1 0.7 4.0 4 0 0 4 4 4 0 Occludin homology domain FCH PF00611.23 AMD18750.1 - 4.3 7.7 6.1 1.4 9.2 1.7 2.6 3 0 0 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain WD40 PF00400.32 AMD18751.1 - 5.5e-23 80.8 6.3 0.0022 18.8 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD18751.1 - 6.8e-13 48.7 1.8 4.1e-06 27.0 0.0 4.9 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 AMD18751.1 - 2.4e-08 33.6 0.3 4.8e-08 32.7 0.3 1.5 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 AMD18751.1 - 1.7e-07 30.9 0.0 3.2e-05 23.4 0.0 2.6 1 1 2 3 3 3 2 WD40-like domain eIF2A PF08662.11 AMD18751.1 - 9.5e-06 25.6 3.3 0.00011 22.2 0.1 3.5 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 AMD18751.1 - 0.0019 16.6 0.1 0.85 7.9 0.0 2.3 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Tfb4 PF03850.14 AMD18752.1 - 1.3e-105 352.8 0.0 1.5e-105 352.6 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Ku_N PF03731.15 AMD18752.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain Rad50_zn_hook PF04423.14 AMD18752.1 - 0.14 12.0 2.0 0.28 11.1 0.4 2.4 3 0 0 3 3 3 0 Rad50 zinc hook motif Put_Phosphatase PF06888.12 AMD18753.1 - 0.029 13.8 0.2 0.033 13.6 0.2 1.2 1 0 0 1 1 1 0 Putative Phosphatase zf-C2H2 PF00096.26 AMD18753.1 - 0.3 11.6 5.5 3.4 8.3 0.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD18753.1 - 4 8.6 6.8 9.6 7.4 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger SIP1 PF04938.12 AMD18754.1 - 5.5e-11 42.6 3.6 9.6e-10 38.5 3.6 2.1 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Cactin_mid PF10312.9 AMD18754.1 - 0.25 11.1 1.6 5.6 6.6 1.6 2.7 1 1 0 1 1 1 0 Conserved mid region of cactin CM_2 PF01817.21 AMD18755.1 - 0.00023 21.5 0.1 0.0074 16.6 0.1 2.6 2 1 0 2 2 2 1 Chorismate mutase type II DnaJ PF00226.31 AMD18756.1 - 5.1e-15 55.3 0.2 1.1e-14 54.3 0.2 1.6 1 0 0 1 1 1 1 DnaJ domain DUF4248 PF14053.6 AMD18756.1 - 0.047 13.7 0.6 0.22 11.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) HofP PF10748.9 AMD18757.1 - 0.11 12.1 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 DNA utilization proteins HofP UPF0139 PF03669.13 AMD18757.1 - 0.12 12.3 1.8 0.26 11.2 1.8 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0139) Vac_ImportDeg PF09783.9 AMD18758.1 - 3.6e-59 199.2 0.4 4.4e-59 198.9 0.4 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein HMG_box PF00505.19 AMD18759.1 - 9e-14 51.6 6.8 5.1e-13 49.2 6.8 2.4 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AMD18759.1 - 3.5e-08 33.9 1.5 3.5e-08 33.9 1.5 2.3 2 0 0 2 2 2 1 HMG-box domain DUF4326 PF14216.6 AMD18759.1 - 0.19 12.5 4.0 0.55 11.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4326) Pho88 PF10032.9 AMD18760.1 - 4e-75 251.1 1.0 4.4e-75 250.9 1.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) ThiF PF00899.21 AMD18761.1 - 5.2e-58 196.3 0.0 6.9e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 AMD18761.1 - 0.026 14.6 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 AMD18761.1 - 0.16 12.2 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Fe-S_biosyn PF01521.20 AMD18762.1 - 2e-13 50.5 0.2 1.4e-11 44.6 0.2 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis YqzH PF14164.6 AMD18762.1 - 0.0012 18.8 0.1 0.0023 17.9 0.1 1.4 1 0 0 1 1 1 1 YqzH-like protein AIM3 PF17096.5 AMD18764.1 - 2e-19 70.3 0.6 2e-19 70.3 0.6 6.4 4 3 2 6 6 6 1 Altered inheritance of mitochondria protein 3 EF-hand_1 PF00036.32 AMD18765.1 - 2.5e-29 98.6 3.8 2.2e-08 33.0 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 AMD18765.1 - 2.6e-25 86.1 2.7 2.6e-08 33.1 0.0 4.3 3 1 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 AMD18765.1 - 1.5e-24 86.2 0.1 2.2e-12 47.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 AMD18765.1 - 2.2e-16 58.5 3.8 4.9e-07 29.0 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 AMD18765.1 - 6e-16 58.0 4.7 3.2e-06 26.9 0.0 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 AMD18765.1 - 1.4e-10 41.4 0.0 3.9e-07 30.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 AMD18765.1 - 2.7e-05 24.5 0.0 0.019 15.3 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 AMD18765.1 - 3.4e-05 24.1 0.0 0.3 11.4 0.0 2.3 1 1 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 AMD18765.1 - 0.00031 20.7 0.0 0.27 11.3 0.0 3.1 4 0 0 4 4 4 1 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.7 AMD18765.1 - 0.0094 15.9 0.1 0.026 14.5 0.1 1.7 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 AMD18765.1 - 0.013 15.7 0.6 1.4 9.1 0.1 2.7 1 1 2 3 3 3 0 Dockerin type I domain DUF853 PF05872.12 AMD18765.1 - 0.017 13.8 0.1 0.046 12.3 0.1 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF3349 PF11829.8 AMD18765.1 - 0.018 15.8 0.2 4.5 8.1 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) Caleosin PF05042.13 AMD18765.1 - 0.023 14.6 0.0 3.9 7.4 0.0 2.6 1 1 2 3 3 3 0 Caleosin related protein RNA_pol_Rpb4 PF03874.16 AMD18765.1 - 0.045 14.1 0.4 0.8 10.0 0.0 2.4 2 1 0 2 2 2 0 RNA polymerase Rpb4 Glycos_transf_1 PF00534.20 AMD18766.1 - 1.5e-10 40.9 0.0 2.4e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AMD18766.1 - 2.6e-06 27.9 0.0 5.2e-06 26.9 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AMD18766.1 - 0.0018 18.7 0.0 0.0029 18.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 AMD18766.1 - 0.0064 16.5 0.1 0.011 15.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Hist_deacetyl PF00850.19 AMD18767.1 - 5.8e-74 249.3 0.0 7.9e-74 248.9 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Spermine_synth PF01564.17 AMD18768.1 - 2.7e-71 238.9 0.1 4.4e-71 238.2 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 AMD18768.1 - 4.7e-26 90.4 0.1 8.2e-26 89.7 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 AMD18768.1 - 0.00024 21.7 0.0 0.0004 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD18768.1 - 0.0075 17.0 0.0 0.019 15.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain IF2_N PF04760.15 AMD18768.1 - 0.03 14.1 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Methyltransf_18 PF12847.7 AMD18768.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Med1 PF10744.9 AMD18769.1 - 4.1e-23 82.1 1.4 3.7e-22 79.0 0.4 2.1 1 1 0 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 NUDIX PF00293.28 AMD18770.1 - 9e-16 58.1 0.0 1.7e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain EnY2 PF10163.9 AMD18771.1 - 4.7e-24 84.6 1.3 5.4e-24 84.4 1.3 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 SinI PF08671.10 AMD18771.1 - 0.0085 15.9 0.4 0.044 13.6 0.3 2.2 2 0 0 2 2 2 1 Anti-repressor SinI TPR_1 PF00515.28 AMD18772.1 - 4.9e-52 171.7 13.8 2.5e-07 30.2 0.0 10.2 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 AMD18772.1 - 4.3e-45 148.2 18.8 0.00016 21.6 0.0 9.9 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_8 PF13181.6 AMD18772.1 - 4.2e-28 95.2 16.5 0.0055 16.8 0.0 10.4 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 AMD18772.1 - 1.7e-27 93.8 24.9 0.00056 20.1 0.1 11.8 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_11 PF13414.6 AMD18772.1 - 1.6e-24 85.3 18.9 5.1e-05 22.9 0.0 9.9 4 2 6 10 10 10 6 TPR repeat TPR_14 PF13428.6 AMD18772.1 - 2.6e-23 80.7 22.8 0.0022 18.7 0.0 10.0 4 3 6 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 AMD18772.1 - 2.8e-23 82.3 21.7 6.5e-05 23.5 0.7 6.7 4 3 3 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 AMD18772.1 - 2e-21 74.4 17.8 0.0021 18.0 0.2 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 AMD18772.1 - 4e-19 68.7 28.7 0.00034 20.8 0.2 8.1 3 2 3 7 7 7 6 Tetratricopeptide repeat TPR_9 PF13371.6 AMD18772.1 - 5.4e-19 68.1 21.5 4.4e-06 26.7 0.0 6.0 3 1 4 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 AMD18772.1 - 2.9e-18 66.1 18.0 0.0067 16.9 1.2 6.9 4 2 1 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 AMD18772.1 - 1e-17 63.5 17.0 0.59 10.9 0.0 9.9 9 0 0 9 9 9 6 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD18772.1 - 2.8e-11 43.5 10.2 0.00018 21.7 0.1 3.8 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 AMD18772.1 - 6e-10 38.8 12.9 0.0029 16.9 0.1 5.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 AMD18772.1 - 2.2e-06 27.3 16.5 0.073 13.0 0.5 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat SNAP PF14938.6 AMD18772.1 - 0.017 14.6 14.5 0.16 11.4 0.1 4.8 4 1 0 5 5 5 0 Soluble NSF attachment protein, SNAP AAA_16 PF13191.6 AMD18772.1 - 0.064 13.6 1.0 0.8 10.1 0.1 2.6 2 0 0 2 2 2 0 AAA ATPase domain Paf67 PF10255.9 AMD18772.1 - 0.21 10.5 3.7 0.36 9.8 1.6 2.3 2 1 0 2 2 2 0 RNA polymerase I-associated factor PAF67 ACOX PF01756.19 AMD18772.1 - 0.6 9.7 2.9 9.2 5.8 0.0 3.2 4 0 0 4 4 4 0 Acyl-CoA oxidase TPR_21 PF09976.9 AMD18772.1 - 1.9 8.2 0.0 1.9 8.2 0.0 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat-like domain SNF2_N PF00176.23 AMD18773.1 - 1.9e-54 184.7 0.2 4.5e-54 183.5 0.2 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD18773.1 - 5.4e-14 52.5 0.0 1.4e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD18773.1 - 2.1e-09 37.6 0.0 4e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 AMD18773.1 - 7.6e-08 32.1 9.6 7.6e-08 32.1 9.6 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 AMD18773.1 - 3.6e-07 30.1 0.0 7.9e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 AMD18773.1 - 0.0005 19.9 8.2 0.0005 19.9 8.2 2.4 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD18773.1 - 0.0019 18.0 7.5 0.0019 18.0 7.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AMD18773.1 - 0.0068 16.7 5.6 0.017 15.4 5.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AMD18773.1 - 0.007 16.7 8.9 0.007 16.7 8.9 2.3 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.6 AMD18773.1 - 0.015 15.2 7.8 0.039 13.8 7.8 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 AMD18773.1 - 0.015 15.3 5.0 0.015 15.3 5.0 1.9 2 0 0 2 2 1 0 RING-type zinc-finger MH2 PF03166.14 AMD18773.1 - 0.026 14.8 0.0 0.054 13.7 0.0 1.5 1 0 0 1 1 1 0 MH2 domain Zn_Tnp_IS91 PF14319.6 AMD18773.1 - 0.41 10.7 11.3 0.06 13.4 2.4 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain SR1P PF13790.6 AMD18773.1 - 1.2 9.4 5.4 2.3 8.4 0.1 2.9 2 0 0 2 2 2 0 SR1 protein zf-Nse PF11789.8 AMD18773.1 - 1.3 8.9 6.0 3.1 7.7 6.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 AMD18773.1 - 6 7.0 10.6 0.056 13.5 1.8 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger NAD_binding_4 PF07993.12 AMD18774.1 - 1.1e-72 244.3 0.0 1.6e-72 243.7 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 AMD18774.1 - 2.1e-64 217.7 0.0 3.1e-64 217.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 AMD18774.1 - 1e-13 51.4 0.0 2.7e-13 50.1 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 AMD18774.1 - 1.9e-12 47.2 0.0 3.2e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 AMD18774.1 - 1.2e-05 24.5 0.0 3.3e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 AMD18774.1 - 0.0028 16.8 0.1 0.0068 15.6 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 AMD18774.1 - 0.0038 16.7 0.0 0.0067 15.9 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Condensation PF00668.20 AMD18774.1 - 0.011 14.5 0.0 1.6 7.3 0.0 2.5 3 0 0 3 3 3 0 Condensation domain AMP-binding_C PF13193.6 AMD18774.1 - 0.014 16.4 0.0 0.052 14.5 0.0 2.1 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain Not3 PF04065.15 AMD18775.1 - 4.7e-64 216.0 30.8 2.6e-61 207.0 30.8 2.3 1 1 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 AMD18775.1 - 2.4e-39 134.4 0.2 8.7e-39 132.6 0.2 2.0 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family CCDC84 PF14968.6 AMD18775.1 - 0.041 13.5 8.1 0.24 11.0 0.8 2.1 1 1 1 2 2 2 0 Coiled coil protein 84 DUF5053 PF16476.5 AMD18775.1 - 0.085 12.5 1.3 0.56 9.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5053) CoA_transf_3 PF02515.17 AMD18775.1 - 0.28 10.2 1.6 0.72 8.9 0.2 1.9 1 1 1 2 2 2 0 CoA-transferase family III Erythro_esteras PF05139.14 AMD18775.1 - 0.53 10.0 2.5 0.59 9.9 0.5 1.8 1 1 1 2 2 2 0 Erythromycin esterase L31 PF09784.9 AMD18775.1 - 0.72 10.3 6.4 0.44 11.0 1.6 2.6 1 1 1 3 3 3 0 Mitochondrial ribosomal protein L31 DUF1168 PF06658.12 AMD18775.1 - 6.7 6.5 9.5 1.4 8.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) LMWPc PF01451.21 AMD18776.1 - 1.1e-45 155.5 0.0 1.2e-45 155.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Transketolase_N PF00456.21 AMD18777.1 - 2.8e-159 529.5 0.0 5.2e-159 528.6 0.0 1.4 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 AMD18777.1 - 1.6e-45 155.0 0.0 2.8e-45 154.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AMD18777.1 - 2e-13 50.3 0.0 4.1e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 AMD18777.1 - 0.00084 18.6 0.1 0.0063 15.8 0.1 2.0 2 1 1 3 3 3 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_N PF02776.18 AMD18777.1 - 0.013 15.2 0.0 3.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain E1_dh PF00676.20 AMD18777.1 - 0.029 13.3 0.0 0.068 12.1 0.0 1.5 2 0 0 2 2 2 0 Dehydrogenase E1 component ThiP_synth PF10120.9 AMD18777.1 - 0.1 12.2 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Thiamine-phosphate synthase Opy2 PF09463.10 AMD18778.1 - 2.8e-09 37.1 20.4 4e-09 36.6 20.4 1.2 1 0 0 1 1 1 1 Opy2 protein Syndecan PF01034.20 AMD18778.1 - 0.0066 16.3 0.5 0.048 13.6 0.2 2.2 2 0 0 2 2 2 1 Syndecan domain Orf78 PF06024.12 AMD18778.1 - 0.028 14.7 0.1 0.14 12.5 0.0 2.1 3 0 0 3 3 3 0 Orf78 (ac78) Phage_holin_2_1 PF04971.12 AMD18778.1 - 0.065 13.2 0.6 0.12 12.4 0.6 1.4 1 0 0 1 1 1 0 Bacteriophage P21 holin S Adeno_E3_CR2 PF02439.15 AMD18778.1 - 0.079 12.7 0.2 0.17 11.7 0.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SKG6 PF08693.10 AMD18778.1 - 0.39 10.2 4.5 0.85 9.1 4.5 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain BNIP2 PF12496.8 AMD18779.1 - 0.045 14.2 0.5 0.088 13.2 0.1 1.7 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CIMR PF00878.18 AMD18780.1 - 5.4e-12 46.0 0.6 4.5e-05 23.6 0.0 2.8 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.15 AMD18780.1 - 3.3e-06 26.4 0.0 4.8e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor PRKCSH_1 PF13015.6 AMD18780.1 - 0.00048 19.8 0.0 0.00081 19.1 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein GTP_EFTU PF00009.27 AMD18781.1 - 1.3e-54 184.7 0.1 1.9e-54 184.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AMD18781.1 - 3e-40 137.0 0.0 7.4e-40 135.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AMD18781.1 - 2.2e-14 53.6 2.1 2.2e-14 53.6 2.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AMD18781.1 - 0.0004 20.5 0.2 0.0095 16.0 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 AMD18781.1 - 0.025 14.5 1.3 0.025 14.5 1.3 2.4 3 0 0 3 3 3 0 Elongation factor Tu domain 4 RRM_1 PF00076.22 AMD18782.1 - 2.1e-12 46.7 1.2 1.5e-07 31.1 0.0 3.4 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 AMD18782.1 - 0.11 12.7 0.2 0.59 10.4 0.1 2.1 2 0 0 2 2 2 0 BRCA1-associated protein 2 Pex14_N PF04695.13 AMD18782.1 - 1.6 9.4 5.3 0.53 10.9 0.2 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Chorein_N PF12624.7 AMD18783.1 - 0.011 15.9 0.1 0.017 15.3 0.1 1.4 1 0 0 1 1 1 0 N-terminal region of Chorein or VPS13 HGTP_anticodon PF03129.20 AMD18784.1 - 5.1e-22 77.8 0.3 2.1e-21 75.9 0.1 2.2 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AMD18784.1 - 5.1e-09 36.4 0.0 4.7e-08 33.2 0.0 2.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DIM1 PF02966.16 AMD18785.1 - 1.7e-68 228.4 0.8 2e-68 228.3 0.8 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 AMD18785.1 - 0.086 12.8 0.1 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin DUF3192 PF11399.8 AMD18785.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) Tau95 PF09734.9 AMD18787.1 - 5.3e-31 108.3 1.0 9.7e-31 107.4 1.0 1.4 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 AMD18787.1 - 2.2e-19 69.9 0.0 5.3e-19 68.7 0.0 1.7 1 0 0 1 1 1 1 Tau95 Triple barrel domain PP2C PF00481.21 AMD18788.1 - 4.8e-63 213.2 0.0 1.4e-62 211.7 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C Glyco_transf_20 PF00982.21 AMD18789.1 - 2.8e-200 666.0 0.1 3.2e-200 665.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 AMD18789.1 - 0.0069 15.9 0.1 0.17 11.4 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 AMD18789.1 - 0.012 15.3 0.1 0.024 14.3 0.1 1.5 1 0 0 1 1 1 0 Starch synthase catalytic domain HMG_box_5 PF14887.6 AMD18790.1 - 0.032 14.2 0.0 0.085 12.8 0.0 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box 5 ATP-synt_ab PF00006.25 AMD18791.1 - 1.3e-66 224.3 0.0 1.8e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AMD18791.1 - 3.4e-15 56.3 0.5 7.2e-15 55.3 0.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Atg14 PF10186.9 AMD18792.1 - 4.7e-13 48.9 11.2 1.4e-11 44.1 11.2 2.6 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Yuri_gagarin PF15934.5 AMD18792.1 - 0.0055 16.6 2.5 0.0082 16.0 2.5 1.2 1 0 0 1 1 1 1 Yuri gagarin MORN_2 PF07661.13 AMD18793.1 - 0.0038 17.3 0.8 0.041 14.1 0.2 2.7 2 0 0 2 2 2 1 MORN repeat variant Ras PF00071.22 AMD18793.1 - 0.0066 16.1 0.0 2.2 7.9 0.0 2.7 3 0 0 3 3 3 2 Ras family AAA_28 PF13521.6 AMD18793.1 - 0.014 15.6 0.0 0.028 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 AMD18793.1 - 0.078 13.1 0.1 0.97 9.5 0.1 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase WD40 PF00400.32 AMD18794.1 - 1.2e-05 25.9 0.2 0.0022 18.8 0.1 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat PH PF00169.29 AMD18795.1 - 1.1e-12 48.4 2.8 2.6e-05 24.7 0.6 2.6 2 1 0 2 2 2 2 PH domain PH_11 PF15413.6 AMD18795.1 - 2.9e-05 24.5 1.3 0.014 15.8 0.3 2.8 2 1 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.6 AMD18795.1 - 0.031 14.6 0.0 9.4 6.6 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain FKBP_C PF00254.28 AMD18795.1 - 0.08 13.3 0.0 4.8 7.6 0.0 2.3 2 0 0 2 2 2 0 FKBP-type peptidyl-prolyl cis-trans isomerase SHE3 PF17078.5 AMD18796.1 - 2.9e-63 213.6 32.7 4e-63 213.2 32.7 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Yuri_gagarin PF15934.5 AMD18796.1 - 0.00025 21.0 11.7 0.00025 21.0 11.7 2.1 1 1 1 2 2 2 1 Yuri gagarin Spc7 PF08317.11 AMD18796.1 - 0.00095 18.1 17.1 0.00095 18.1 17.1 2.2 1 1 1 2 2 2 1 Spc7 kinetochore protein Tex_N PF09371.10 AMD18796.1 - 0.0032 17.2 1.0 0.0032 17.2 1.0 2.7 2 1 0 2 2 2 1 Tex-like protein N-terminal domain TMF_DNA_bd PF12329.8 AMD18796.1 - 0.0053 16.7 7.7 0.0053 16.7 7.7 3.8 2 2 1 3 3 3 1 TATA element modulatory factor 1 DNA binding PI_PP_I PF18363.1 AMD18796.1 - 0.0073 16.5 9.8 0.083 13.1 0.7 3.1 2 1 0 2 2 2 1 Phosphoinositide phosphatase insertion domain Rab5-bind PF09311.11 AMD18796.1 - 0.0098 15.3 7.8 0.0098 15.3 7.8 2.2 1 1 1 2 2 2 1 Rabaptin-like protein Csm1_N PF18504.1 AMD18796.1 - 0.011 16.1 1.8 0.011 16.1 1.8 4.3 1 1 2 4 4 4 0 Csm1 N-terminal domain Uds1 PF15456.6 AMD18796.1 - 0.037 14.2 18.9 0.78 9.9 2.8 2.6 2 0 0 2 2 2 0 Up-regulated During Septation CCDC144C PF14915.6 AMD18796.1 - 0.066 12.3 27.1 1.5 7.9 26.6 2.2 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region CENP-F_leu_zip PF10473.9 AMD18796.1 - 0.094 12.7 28.1 0.47 10.5 13.7 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cluap1 PF10234.9 AMD18796.1 - 0.1 12.0 25.9 0.079 12.4 22.0 2.4 1 1 1 2 2 2 0 Clusterin-associated protein-1 Jnk-SapK_ap_N PF09744.9 AMD18796.1 - 0.12 12.6 28.8 1.9 8.7 14.7 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 AMD18796.1 - 0.19 11.8 25.8 2 8.5 25.7 2.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 AMD18796.1 - 0.24 10.7 32.3 1 8.7 32.1 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Mod_r PF07200.13 AMD18796.1 - 0.27 11.3 26.5 0.55 10.3 7.0 3.0 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein SlyX PF04102.12 AMD18796.1 - 0.54 10.9 0.1 0.54 10.9 0.1 3.8 2 1 1 4 4 4 0 SlyX DUF724 PF05266.14 AMD18796.1 - 0.69 9.7 20.0 0.066 13.0 8.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ADIP PF11559.8 AMD18796.1 - 0.71 9.9 26.2 0.16 12.1 14.0 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Snapin_Pallidin PF14712.6 AMD18796.1 - 0.83 10.1 20.1 4.9 7.6 1.9 3.6 1 1 1 3 3 3 0 Snapin/Pallidin Peptidase_S46 PF10459.9 AMD18796.1 - 1.2 7.6 16.5 1.8 7.1 16.5 1.2 1 0 0 1 1 1 0 Peptidase S46 NPV_P10 PF05531.12 AMD18796.1 - 2 9.0 9.2 9.8 6.7 0.1 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein HrpB7 PF09486.10 AMD18796.1 - 2.2 8.6 8.2 0.99 9.8 4.5 2.2 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) IFT57 PF10498.9 AMD18796.1 - 2.8 6.8 25.0 0.014 14.4 9.7 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Fez1 PF06818.15 AMD18796.1 - 2.9 8.3 23.8 11 6.5 23.0 2.1 1 1 0 1 1 1 0 Fez1 DUF4164 PF13747.6 AMD18796.1 - 5 7.5 13.0 1.3 9.3 1.1 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) DUF745 PF05335.13 AMD18796.1 - 5.8 6.6 17.0 0.055 13.2 4.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DUF3552 PF12072.8 AMD18796.1 - 7.4 5.9 28.3 0.16 11.3 7.7 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF3552) COG5 PF10392.9 AMD18796.1 - 7.5 6.7 16.7 5 7.3 6.4 2.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 GCN5L1 PF06320.13 AMD18796.1 - 9 6.5 17.8 0.22 11.7 3.9 3.1 1 1 2 3 3 3 0 GCN5-like protein 1 (GCN5L1) SRP54 PF00448.22 AMD18797.1 - 6.9e-78 260.8 2.1 6.9e-78 260.8 2.1 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 AMD18797.1 - 1.7e-29 102.4 6.0 1.7e-29 102.4 6.0 4.0 3 1 1 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.19 AMD18797.1 - 1.2e-13 51.1 3.8 3.1e-13 49.7 3.8 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 AMD18797.1 - 2e-05 24.3 2.2 0.00017 21.2 1.3 2.8 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 AMD18797.1 - 0.00015 21.8 0.0 0.00059 19.9 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 AMD18797.1 - 0.00094 19.4 0.2 0.0049 17.0 0.0 2.3 3 0 0 3 3 2 1 AAA domain AAA_17 PF13207.6 AMD18797.1 - 0.0016 18.8 1.0 0.0076 16.7 0.1 2.6 2 1 0 2 2 2 1 AAA domain VirE PF05272.11 AMD18797.1 - 0.0082 15.9 0.1 0.024 14.4 0.1 1.8 1 0 0 1 1 1 1 Virulence-associated protein E SRPRB PF09439.10 AMD18797.1 - 0.0097 15.4 4.4 1.4 8.3 0.2 3.5 3 1 0 4 4 4 1 Signal recognition particle receptor beta subunit MobB PF03205.14 AMD18797.1 - 0.011 15.7 0.0 0.032 14.1 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.23 AMD18797.1 - 0.017 15.2 0.5 0.084 13.0 0.1 2.4 3 1 0 3 3 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 AMD18797.1 - 0.021 15.1 0.3 0.075 13.3 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AMD18797.1 - 0.022 15.1 0.0 0.046 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 AMD18797.1 - 0.024 14.4 0.1 0.078 12.8 0.1 1.9 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 AMD18797.1 - 0.025 14.4 0.6 2.7 7.7 0.0 2.9 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 AMD18797.1 - 0.034 14.7 0.0 0.13 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AMD18797.1 - 0.046 13.4 0.1 0.13 12.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 AMD18797.1 - 0.066 13.1 0.2 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase Zeta_toxin PF06414.12 AMD18797.1 - 0.067 12.5 0.0 0.15 11.3 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 AMD18797.1 - 0.089 12.5 2.0 0.16 11.7 0.1 2.5 3 0 0 3 3 3 0 AAA domain AAA_31 PF13614.6 AMD18797.1 - 0.12 12.3 3.2 0.24 11.3 0.3 2.7 2 1 0 2 2 2 0 AAA domain FAD_binding_4 PF01565.23 AMD18797.1 - 0.12 12.1 0.1 0.6 9.9 0.1 2.1 2 0 0 2 2 2 0 FAD binding domain ArsA_ATPase PF02374.15 AMD18797.1 - 0.71 9.0 10.4 0.44 9.7 0.1 4.0 4 0 0 4 4 4 0 Anion-transporting ATPase COMPASS-Shg1 PF05205.12 AMD18797.1 - 6.6 7.5 8.5 23 5.8 1.6 3.9 4 0 0 4 4 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 DUF1712 PF08217.11 AMD18798.1 - 3.4e-160 534.5 5.9 4e-160 534.2 5.9 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) AA_permease PF00324.21 AMD18800.1 - 4.5e-112 375.1 38.0 5.3e-112 374.8 38.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD18800.1 - 3.5e-21 75.5 40.0 4.8e-21 75.1 40.0 1.1 1 0 0 1 1 1 1 Amino acid permease DIL PF01843.19 AMD18801.1 - 5e-18 65.3 5.9 2.3e-16 60.0 5.2 3.1 3 1 0 3 3 3 1 DIL domain Ank_2 PF12796.7 AMD18801.1 - 0.00019 22.0 0.0 0.0006 20.3 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AMD18801.1 - 0.0014 18.9 0.4 0.076 13.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 AMD18801.1 - 0.003 18.1 0.1 0.59 10.8 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD18801.1 - 0.02 15.4 0.1 0.6 10.8 0.0 3.1 2 0 0 2 2 2 0 Ankyrin repeat PRMT5_TIM PF17285.2 AMD18802.1 - 6.3e-65 218.9 0.0 1.1e-64 218.1 0.0 1.5 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 AMD18802.1 - 2.5e-59 200.0 0.3 5e-59 199.0 0.0 1.6 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 AMD18802.1 - 1e-58 198.1 0.8 1.6e-58 197.5 0.8 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain DUF2718 PF10918.8 AMD18802.1 - 0.3 11.6 2.0 2.5 8.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2718) CKS PF01111.19 AMD18803.1 - 7.6e-34 115.8 0.2 1.3e-33 115.1 0.2 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit PI3_PI4_kinase PF00454.27 AMD18804.1 - 1.6e-52 178.8 0.3 4.2e-52 177.5 0.3 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 AMD18804.1 - 3.4e-24 84.7 0.1 2.3e-23 82.0 0.1 2.7 1 0 0 1 1 1 1 UME (NUC010) domain FATC PF02260.20 AMD18804.1 - 2.1e-14 53.0 0.4 6.4e-14 51.5 0.4 1.9 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 AMD18804.1 - 1e-08 34.8 0.7 1e-08 34.8 0.7 2.8 2 1 0 2 2 2 1 FAT domain MMM1 PF10296.9 AMD18805.1 - 3.7e-09 36.1 1.5 1.2e-08 34.4 0.3 2.3 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 AMD18805.1 - 0.013 16.0 0.8 0.43 11.1 0.2 3.1 2 0 0 2 2 2 0 PH domain DUF4974 PF16344.5 AMD18805.1 - 0.045 13.8 1.0 0.71 9.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4974) Cofilin_ADF PF00241.20 AMD18807.1 - 8.6e-28 96.6 0.0 5.3e-14 52.1 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Orthopox_A49R PF06489.11 AMD18807.1 - 0.065 13.5 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Orthopoxvirus A49R protein GIY-YIG PF01541.24 AMD18807.1 - 0.076 13.3 0.0 0.23 11.8 0.0 1.7 2 0 0 2 2 2 0 GIY-YIG catalytic domain zf-RING_2 PF13639.6 AMD18808.1 - 4.6e-08 33.3 14.7 7.1e-08 32.7 14.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AMD18808.1 - 4.6e-06 26.8 13.7 1.1e-05 25.6 13.7 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AMD18808.1 - 2.5e-05 24.0 12.7 4.1e-05 23.3 12.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AMD18808.1 - 5e-05 23.0 7.0 0.00011 21.8 7.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 AMD18808.1 - 0.00096 18.9 13.1 0.0017 18.1 13.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AMD18808.1 - 0.001 19.1 6.6 0.001 19.1 6.6 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 AMD18808.1 - 0.0011 18.8 10.5 0.0018 18.2 10.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AMD18808.1 - 0.0025 17.8 5.5 0.0025 17.8 5.5 1.9 1 1 1 2 2 2 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 AMD18808.1 - 0.0052 16.4 11.8 0.018 14.7 10.7 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 AMD18808.1 - 0.014 15.2 11.0 0.025 14.4 11.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 AMD18808.1 - 0.015 15.2 11.0 0.022 14.6 11.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Di19 PF05605.12 AMD18808.1 - 0.062 13.6 7.5 0.27 11.5 0.5 2.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_4 PF14447.6 AMD18808.1 - 0.58 10.1 13.8 8.7 6.3 13.7 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 AMD18808.1 - 1.5 9.1 9.5 3.9 7.7 9.6 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 AMD18808.1 - 2.7 8.2 5.7 19 5.5 5.7 2.1 1 1 0 1 1 1 0 Zinc-binding RING-finger PHF5 PF03660.14 AMD18809.1 - 8.9e-52 173.7 12.0 9.9e-52 173.5 12.0 1.0 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.7 AMD18809.1 - 2.1 8.4 17.5 1.3 9.2 10.9 2.8 1 1 2 3 3 3 0 Double zinc ribbon PolC_DP2 PF03833.13 AMD18809.1 - 2.3 6.0 10.9 2.5 5.9 10.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Sec7 PF01369.20 AMD18810.1 - 4.2e-25 88.5 2.4 7.5e-25 87.7 1.5 1.8 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 AMD18810.1 - 0.0014 19.0 0.0 0.0034 17.8 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AMD18810.1 - 0.0015 19.0 0.0 0.0062 17.0 0.0 2.1 1 1 0 1 1 1 1 PH domain PH_6 PF15406.6 AMD18810.1 - 0.043 14.1 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4149 PF13664.6 AMD18811.1 - 1.4e-17 63.8 2.0 1.4e-17 63.8 2.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) TraU PF06834.11 AMD18811.1 - 0.15 11.3 0.1 0.2 10.9 0.1 1.1 1 0 0 1 1 1 0 TraU protein MAS20 PF02064.15 AMD18812.1 - 3.5e-36 124.2 1.5 4.2e-36 123.9 1.5 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor Cas_Csy4 PF09618.10 AMD18812.1 - 0.064 13.4 0.1 0.089 12.9 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) PfkB PF00294.24 AMD18812.1 - 0.11 11.7 0.2 0.18 11.1 0.2 1.2 1 0 0 1 1 1 0 pfkB family carbohydrate kinase TSA PF03249.13 AMD18812.1 - 0.11 11.2 1.3 0.18 10.5 0.9 1.4 2 0 0 2 2 2 0 Type specific antigen SLX9 PF15341.6 AMD18813.1 - 4.7e-24 85.3 7.5 4.7e-24 85.3 7.5 1.7 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 DUF3818 PF12825.7 AMD18814.1 - 1.2e-94 317.1 1.3 1.2e-94 317.1 1.3 2.0 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 AMD18814.1 - 3.7e-36 124.0 1.6 3.7e-36 124.0 1.6 2.5 3 0 0 3 3 3 1 PX-associated PX PF00787.24 AMD18814.1 - 1.4e-11 44.3 0.9 7e-11 42.1 0.1 2.7 3 0 0 3 3 3 1 PX domain L51_S25_CI-B8 PF05047.16 AMD18815.1 - 1.4e-12 47.3 0.0 2.3e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF4034 PF13226.6 AMD18815.1 - 0.15 11.4 0.1 0.21 10.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4034) IF-2B PF01008.17 AMD18816.1 - 1.2e-103 346.2 0.1 1.2e-103 346.2 0.1 1.6 2 0 0 2 2 2 1 Initiation factor 2 subunit family LCD1 PF09798.9 AMD18816.1 - 0.00018 20.2 5.2 0.00038 19.1 5.2 1.5 1 0 0 1 1 1 1 DNA damage checkpoint protein Ndc1_Nup PF09531.10 AMD18816.1 - 9.5 4.8 9.2 17 3.9 9.2 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BCAS2 PF05700.11 AMD18818.1 - 0.0016 18.2 11.3 0.01 15.5 11.3 2.0 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Glu-tRNAGln PF02686.15 AMD18818.1 - 0.018 15.3 0.8 0.67 10.3 0.1 2.6 2 1 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit DUF1622 PF07784.11 AMD18818.1 - 0.24 11.4 0.5 3 7.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1622) Ribosomal_L5_C PF00673.21 AMD18819.1 - 9.1e-22 77.1 0.0 1.3e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AMD18819.1 - 1.9e-19 69.7 0.0 5e-19 68.4 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 AMD18819.1 - 0.007 16.1 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain Proteasome PF00227.26 AMD18820.1 - 1.4e-46 158.4 0.1 1.7e-46 158.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Forkhead PF00250.18 AMD18821.1 - 4.9e-25 87.6 0.1 1.2e-24 86.3 0.1 1.7 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 AMD18821.1 - 1.8e-11 44.2 0.2 4.3e-11 43.0 0.2 1.7 1 0 0 1 1 1 1 FHA domain U1snRNP70_N PF12220.8 AMD18821.1 - 1.1 9.9 0.0 1.1 9.9 0.0 4.3 5 0 0 5 5 5 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Ribosomal_L37 PF08561.10 AMD18821.1 - 2.8 8.5 10.8 1 9.9 5.8 2.8 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 COG4 PF08318.12 AMD18822.1 - 3.5e-82 276.2 0.8 7.5e-82 275.1 0.8 1.6 1 0 0 1 1 1 1 COG4 transport protein DUF2935 PF11155.8 AMD18822.1 - 0.37 11.1 8.8 0.52 10.6 1.4 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF2935) Tropomyosin_1 PF12718.7 AMD18822.1 - 0.76 9.9 6.9 1.8 8.7 6.9 1.6 1 0 0 1 1 1 0 Tropomyosin like Pil1 PF13805.6 AMD18823.1 - 1.5e-123 411.4 0.1 1.9e-123 411.2 0.1 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 Pkinase PF00069.25 AMD18824.1 - 3.9e-21 75.6 0.0 5.5e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18824.1 - 1.7e-07 30.8 0.0 2.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD18824.1 - 0.00054 19.4 0.0 0.0016 17.8 0.0 1.7 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 AMD18824.1 - 0.0091 15.9 0.0 0.089 12.7 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 AMD18824.1 - 0.057 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family zf_CCCH_4 PF18345.1 AMD18825.1 - 2.3e-15 56.1 36.3 6.5e-06 26.0 2.5 5.6 6 0 0 6 6 6 5 Zinc finger domain zf-CCCH PF00642.24 AMD18825.1 - 8.2e-14 51.1 28.6 0.00069 19.5 0.5 5.4 4 2 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 AMD18825.1 - 6.9e-12 46.0 22.2 0.0029 18.3 0.5 5.1 1 1 4 5 5 5 4 Torus domain zf-CCCH_3 PF15663.5 AMD18825.1 - 1.6e-06 28.3 14.9 3.1e-06 27.4 5.4 2.7 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 AMD18825.1 - 0.0061 16.3 5.8 0.029 14.2 1.3 5.3 5 3 0 5 5 5 3 CCCH-type zinc finger Nab2p_Zf1 PF18260.1 AMD18825.1 - 0.86 9.6 17.1 1.3 9.0 0.2 4.4 4 0 0 4 4 4 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 FUN14 PF04930.15 AMD18826.1 - 1.9e-09 37.8 0.6 3e-09 37.1 0.6 1.3 1 0 0 1 1 1 1 FUN14 family B56 PF01603.20 AMD18827.1 - 7.6e-172 571.9 8.7 1.1e-171 571.4 8.7 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DltD PF04914.12 AMD18827.1 - 1.4 8.2 4.9 7.7 5.8 0.8 2.1 2 0 0 2 2 2 0 DltD protein Spo7 PF03907.13 AMD18828.1 - 8.4e-70 234.7 8.2 1.2e-69 234.2 8.2 1.2 1 0 0 1 1 1 1 Spo7-like protein OPT PF03169.15 AMD18828.1 - 0.0021 16.8 0.1 0.0028 16.4 0.1 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MDM10 PF12519.8 AMD18829.1 - 3.3e-141 471.3 11.9 3.7e-141 471.2 11.9 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 TOC159_MAD PF11886.8 AMD18829.1 - 0.034 13.1 0.0 0.052 12.4 0.0 1.3 1 0 0 1 1 1 0 Translocase of chloroplast 159/132, membrane anchor domain SMC_N PF02463.19 AMD18831.1 - 1.6e-20 73.5 15.5 1.4e-19 70.4 15.5 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AMD18831.1 - 4.6e-15 56.7 30.2 4.6e-15 56.7 30.2 5.7 2 2 1 3 3 2 1 AAA domain AAA_29 PF13555.6 AMD18831.1 - 6.8e-05 22.5 0.0 0.00014 21.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 AMD18831.1 - 0.0094 15.8 0.1 0.0094 15.8 0.1 2.8 4 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 AMD18831.1 - 0.014 15.3 0.0 0.075 13.0 0.0 2.3 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 AMD18831.1 - 0.041 14.4 0.0 0.041 14.4 0.0 5.0 4 2 0 4 4 3 0 ABC transporter AAA_25 PF13481.6 AMD18831.1 - 0.064 12.8 0.0 0.28 10.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain Annexin_like PF18411.1 AMD18831.1 - 0.083 13.2 0.2 0.36 11.1 0.2 2.1 1 0 0 1 1 1 0 Annexin-like domain AAA_27 PF13514.6 AMD18831.1 - 0.095 12.3 9.3 0.095 12.3 0.0 4.0 3 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 AMD18831.1 - 0.14 11.4 5.4 1.3 8.3 0.0 3.6 2 1 0 3 3 3 0 FtsK/SpoIIIE family DASH_Dam1 PF08653.10 AMD18831.1 - 0.41 10.5 3.5 30 4.5 0.1 4.3 4 0 0 4 4 4 0 DASH complex subunit Dam1 AAA_13 PF13166.6 AMD18831.1 - 4.5 5.8 77.6 1.1 7.8 5.3 6.1 3 2 3 6 6 6 0 AAA domain tRNA-synt_1c PF00749.21 AMD18832.1 - 3.6e-106 354.6 0.0 5e-106 354.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DUF775 PF05603.12 AMD18833.1 - 7.2e-63 211.7 0.2 8.1e-63 211.6 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) DUF515 PF04415.12 AMD18833.1 - 0.056 11.8 0.0 0.077 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) SIL1 PF16782.5 AMD18834.1 - 1.8e-79 267.0 0.5 2.2e-79 266.7 0.5 1.1 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 Cys_Met_Meta_PP PF01053.20 AMD18835.1 - 6.8e-145 482.4 0.1 7.8e-145 482.2 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 AMD18835.1 - 1.3e-07 31.2 0.4 3.3e-07 29.8 0.3 1.6 1 1 1 2 2 2 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 AMD18835.1 - 3.2e-05 22.7 0.0 4.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_5 PF00266.19 AMD18835.1 - 0.0066 15.4 0.1 0.011 14.8 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AMD18835.1 - 0.079 12.2 0.1 0.24 10.7 0.1 1.8 1 1 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AMD18835.1 - 0.12 11.7 0.2 0.59 9.4 0.1 2.1 2 1 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Ribosomal_60s PF00428.19 AMD18836.1 - 2.7e-24 85.5 11.6 3.2e-24 85.3 11.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_S19 PF00203.21 AMD18837.1 - 5.9e-34 115.8 0.1 8.1e-34 115.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Sds3 PF08598.11 AMD18838.1 - 4.5e-49 167.4 0.2 4.5e-49 167.4 0.2 1.9 2 0 0 2 2 2 1 Sds3-like RRM_1 PF00076.22 AMD18839.1 - 1.9e-18 66.0 0.8 7.2e-16 57.8 0.1 3.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD18839.1 - 1.8e-05 24.7 1.6 0.0086 16.2 0.0 3.4 2 1 1 3 3 3 2 RNA recognition motif MRC1 PF09444.10 AMD18839.1 - 0.07 13.6 20.5 0.17 12.4 20.5 1.6 1 0 0 1 1 1 0 MRC1-like domain Spo7_2_N PF15407.6 AMD18839.1 - 0.11 12.1 0.0 0.5 10.0 0.0 2.1 2 0 0 2 2 2 0 Sporulation protein family 7 CDC45 PF02724.14 AMD18839.1 - 2.8 6.1 19.1 5 5.3 19.1 1.3 1 0 0 1 1 1 0 CDC45-like protein CDC27 PF09507.10 AMD18839.1 - 3.9 6.8 34.1 1.2 8.4 25.9 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 SNARE PF05739.19 AMD18840.1 - 0.018 15.0 0.1 0.051 13.6 0.1 1.8 1 0 0 1 1 1 0 SNARE domain Glyco_hyd_101C PF17451.2 AMD18841.1 - 0.076 13.3 0.1 0.12 12.7 0.1 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain HhH-GPD PF00730.25 AMD18842.1 - 4.6e-19 68.9 0.0 8.8e-19 68.0 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AMD18842.1 - 4.6e-05 23.1 0.1 0.00019 21.1 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif HEAT PF02985.22 AMD18843.1 - 2.7e-41 136.0 22.6 0.0047 17.1 0.1 13.2 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.6 AMD18843.1 - 5.4e-30 103.6 8.7 4.1e-09 36.7 0.0 7.7 4 3 1 6 6 6 6 HEAT repeats Vac14_Fab1_bd PF12755.7 AMD18843.1 - 3.5e-15 56.4 9.5 0.03 14.9 0.4 8.8 3 3 5 9 9 9 5 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 AMD18843.1 - 5.1e-12 46.0 11.9 0.37 11.3 0.2 8.7 7 1 3 10 10 10 4 HEAT-like repeat Cnd1 PF12717.7 AMD18843.1 - 4.5e-09 36.5 17.9 0.0058 16.7 1.2 6.6 1 1 6 7 7 7 4 non-SMC mitotic condensation complex subunit 1 Ecm29 PF13001.7 AMD18843.1 - 0.00033 19.5 6.8 0.0048 15.6 0.2 4.1 2 2 2 5 5 5 1 Proteasome stabiliser M11L PF11099.8 AMD18843.1 - 0.0027 18.0 6.3 0.16 12.2 0.1 3.6 2 1 2 4 4 4 2 Apoptosis regulator M11L like API5 PF05918.11 AMD18843.1 - 0.01 14.7 0.8 0.01 14.7 0.8 4.2 3 1 1 5 5 5 0 Apoptosis inhibitory protein 5 (API5) DUF1981 PF09324.10 AMD18843.1 - 0.012 15.4 0.1 13 5.7 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1981) Importin_rep_4 PF18808.1 AMD18843.1 - 0.096 13.0 1.3 23 5.4 0.1 4.2 4 1 0 4 4 4 0 Importin repeat DNA_alkylation PF08713.11 AMD18843.1 - 0.98 9.1 8.1 11 5.7 0.0 4.8 3 2 2 6 6 6 0 DNA alkylation repair enzyme Arm PF00514.23 AMD18843.1 - 1.2 9.3 10.6 2 8.6 0.1 5.5 6 1 1 7 7 7 0 Armadillo/beta-catenin-like repeat Pox_MCEL PF03291.16 AMD18844.1 - 0.023 13.8 0.1 0.036 13.2 0.1 1.2 1 0 0 1 1 1 0 mRNA capping enzyme Pkinase PF00069.25 AMD18845.1 - 1.3e-59 201.7 0.0 2.4e-59 200.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18845.1 - 4.2e-20 72.1 0.0 7.2e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD18845.1 - 4.8e-06 26.1 0.0 8.4e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AMD18845.1 - 0.00057 19.3 0.1 0.0011 18.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD18845.1 - 0.00067 19.6 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AMD18845.1 - 0.0076 15.1 0.0 0.016 14.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 AMD18845.1 - 0.03 13.9 0.0 0.065 12.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Ribonuc_2-5A PF06479.12 AMD18845.1 - 0.14 12.3 0.5 0.38 10.9 0.5 1.7 1 0 0 1 1 1 0 Ribonuclease 2-5A EI24 PF07264.11 AMD18847.1 - 3.3e-07 30.7 19.2 4.4e-07 30.3 19.2 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) GSH_synth_ATP PF03917.17 AMD18848.1 - 1.4e-126 422.3 0.0 1.6e-126 422.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 AMD18848.1 - 1.3e-31 109.1 0.1 2.5e-31 108.1 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Med15_fungi PF05397.12 AMD18849.1 - 4e-34 117.3 6.8 4e-34 117.3 6.8 10.8 5 3 3 8 8 8 1 Mediator complex subunit 15 SNF2_N PF00176.23 AMD18850.1 - 1.5e-58 198.2 0.4 1.5e-58 198.2 0.4 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD18850.1 - 1.2e-21 77.1 0.1 1.8e-17 63.7 0.1 2.9 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 AMD18850.1 - 1.7e-12 47.7 0.0 6.8e-12 45.7 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AMD18850.1 - 9e-08 32.1 0.0 2.6e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 AMD18850.1 - 0.0002 20.7 0.1 0.0002 20.7 0.1 2.0 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CUE PF02845.16 AMD18850.1 - 0.0032 17.1 0.0 0.0083 15.8 0.0 1.8 1 0 0 1 1 1 1 CUE domain Myc_N PF01056.18 AMD18850.1 - 3.5 7.4 17.4 1 9.2 9.4 2.7 2 0 0 2 2 2 0 Myc amino-terminal region RCC1 PF00415.18 AMD18851.1 - 3.9e-26 91.4 16.4 4.9e-09 36.7 0.1 7.0 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AMD18851.1 - 4e-18 64.7 24.2 5.5e-09 35.6 0.4 6.5 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Exo_endo_phos PF03372.23 AMD18852.1 - 6.1e-23 81.5 0.0 1e-22 80.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 AMD18852.1 - 2.7e-13 49.5 5.8 2.9e-08 33.4 1.0 3.1 1 1 2 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 AMD18852.1 - 6.2e-10 39.2 10.2 2.5e-06 27.7 2.5 3.3 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 AMD18852.1 - 0.0004 20.5 7.7 0.25 12.0 0.2 4.6 4 0 0 4 4 4 2 Leucine Rich Repeat GPCR_chapero_1 PF11904.8 AMD18852.1 - 0.018 14.5 0.0 0.055 12.9 0.0 1.8 1 1 0 1 1 1 0 GPCR-chaperone Sigma_1s PF02454.16 AMD18852.1 - 0.031 14.3 0.2 0.075 13.0 0.2 1.6 1 0 0 1 1 1 0 Sigma 1s protein RsmF_methylt_CI PF17126.5 AMD18852.1 - 0.075 13.1 0.1 1.2 9.3 0.0 2.8 3 0 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain DUF908 PF06012.12 AMD18852.1 - 0.34 10.3 8.7 0.52 9.7 8.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) LRR_6 PF13516.6 AMD18852.1 - 1.5 9.0 4.1 3.1 8.1 0.4 2.7 2 0 0 2 2 2 0 Leucine Rich repeat BAF1_ABF1 PF04684.13 AMD18853.1 - 9.1e-148 493.8 45.8 4.9e-78 263.6 3.2 4.2 1 1 3 4 4 4 4 BAF1 / ABF1 chromatin reorganising factor Ydc2-catalyt PF09159.10 AMD18853.1 - 0.017 14.9 1.3 0.043 13.5 1.3 1.7 1 0 0 1 1 1 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 DBD_Tnp_Mut PF03108.15 AMD18853.1 - 0.017 15.1 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 MuDR family transposase DUF2141 PF09912.9 AMD18853.1 - 0.061 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) MOR2-PAG1_N PF14222.6 AMD18853.1 - 0.095 11.6 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Cell morphogenesis N-terminal mRNA_stabil PF13929.6 AMD18854.1 - 8.4e-47 159.5 15.8 1.6e-46 158.6 13.9 1.9 2 0 0 2 2 2 1 mRNA stabilisation RsfS PF02410.15 AMD18854.1 - 8e-16 58.3 0.0 2.1e-15 57.0 0.0 1.8 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation FtsK_SpoIIIE PF01580.18 AMD18854.1 - 0.1 11.9 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family KTI12 PF08433.10 AMD18855.1 - 1.1e-93 313.6 0.1 1.3e-93 313.5 0.1 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 AMD18855.1 - 2.4e-05 24.5 0.0 4.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AMD18855.1 - 0.0001 22.6 0.5 0.0016 18.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.20 AMD18855.1 - 0.00018 21.4 0.0 0.00037 20.4 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 AMD18855.1 - 0.0051 17.4 0.3 0.013 16.0 0.1 1.9 2 2 0 2 2 2 1 AAA domain AAA PF00004.29 AMD18855.1 - 0.0057 17.1 0.2 0.027 14.9 0.1 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 AMD18855.1 - 0.0086 15.5 0.3 0.044 13.2 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Mg_chelatase PF01078.21 AMD18855.1 - 0.017 14.5 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 AMD18855.1 - 0.02 15.3 0.0 0.091 13.1 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 AMD18855.1 - 0.023 14.7 0.0 0.12 12.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 AMD18855.1 - 0.033 14.1 0.2 0.41 10.6 0.0 2.8 2 1 1 3 3 3 0 NACHT domain DUF2226 PF09987.9 AMD18855.1 - 0.036 13.4 0.2 0.075 12.4 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2226) AAA_17 PF13207.6 AMD18855.1 - 0.077 13.4 0.0 0.18 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AMD18855.1 - 0.1 12.5 0.4 0.29 11.1 0.0 1.9 2 1 0 2 2 2 0 NTPase SRP54 PF00448.22 AMD18855.1 - 0.1 12.2 0.1 0.22 11.1 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.19 AMD18855.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 AMD18855.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 AMD18856.1 - 6.5e-13 48.8 0.0 2e-12 47.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD18856.1 - 4e-09 36.6 0.6 9.3e-05 22.4 0.2 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 AMD18856.1 - 1.9e-05 24.2 0.0 3.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 AMD18856.1 - 0.019 15.5 0.0 0.04 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AIG1 PF04548.16 AMD18856.1 - 0.047 13.0 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 AMD18856.1 - 0.072 13.1 0.0 6.7 6.7 0.1 2.5 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 AMD18856.1 - 0.11 12.7 0.0 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Hap4_Hap_bind PF10297.9 AMD18857.1 - 2.6e-08 33.7 8.4 4.7e-08 32.9 8.4 1.5 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 AMD18857.1 - 0.1 12.7 3.2 0.17 12.0 3.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor DUF5320 PF17253.2 AMD18857.1 - 0.18 12.9 0.0 0.83 10.8 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Drc1-Sld2 PF11719.8 AMD18859.1 - 6.5e-44 151.2 23.1 2.8e-27 96.4 14.4 2.1 1 1 1 2 2 2 2 DNA replication and checkpoint protein MATalpha_HMGbox PF04769.12 AMD18859.1 - 0.093 12.0 0.3 0.16 11.2 0.3 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box SPT6_acidic PF14632.6 AMD18859.1 - 3.3 8.3 11.9 6.6 7.4 1.0 2.4 1 1 1 2 2 2 0 Acidic N-terminal SPT6 UTP15_C PF09384.10 AMD18860.1 - 2.1e-44 150.7 0.0 3.2e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 AMD18860.1 - 9.5e-16 57.9 4.0 0.0055 17.5 0.0 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD18860.1 - 0.00012 22.3 0.0 0.16 12.3 0.0 4.3 1 1 4 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain DUF5122 PF17164.4 AMD18860.1 - 0.22 11.9 1.6 0.5 10.7 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller ANAPC4_WD40 PF12894.7 AMD18861.1 - 3.2e-14 53.0 2.3 0.00046 20.4 0.1 7.5 3 3 3 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD18861.1 - 6.3e-12 45.8 19.4 1.3 10.0 0.0 10.1 11 0 0 11 11 11 4 WD domain, G-beta repeat WD40_like PF17005.5 AMD18861.1 - 5.7e-06 25.9 1.0 0.1 11.9 0.1 2.8 1 1 2 3 3 3 2 WD40-like domain eIF2A PF08662.11 AMD18861.1 - 5.9e-05 23.0 0.2 0.1 12.5 0.0 3.3 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 AMD18861.1 - 0.0006 19.5 1.5 0.009 15.6 1.4 2.8 1 1 0 1 1 1 1 PQQ-like domain DUF1580 PF07618.11 AMD18861.1 - 0.031 13.9 0.0 0.67 9.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1580) Meleagrin PF08189.11 AMD18861.1 - 0.072 12.8 0.5 0.17 11.6 0.5 1.6 1 0 0 1 1 1 0 Meleagrin/Cygnin family POTRA_2 PF08479.11 AMD18861.1 - 0.087 12.7 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 POTRA domain, ShlB-type PQQ PF01011.21 AMD18861.1 - 0.41 10.7 2.7 8.4 6.5 0.0 4.1 4 0 0 4 4 4 0 PQQ enzyme repeat CRC_subunit PF08624.10 AMD18862.1 - 2.7e-53 180.0 0.0 4.7e-53 179.2 0.0 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Nop14 PF04147.12 AMD18862.1 - 7 4.7 35.3 9.5 4.3 35.3 1.1 1 0 0 1 1 1 0 Nop14-like family Peptidase_M41 PF01434.18 AMD18863.1 - 6.1e-65 218.7 1.3 1.2e-64 217.7 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 AMD18863.1 - 1.9e-42 144.8 0.0 4.9e-42 143.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD18863.1 - 6e-13 48.4 0.2 2e-12 46.7 0.2 1.9 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 AMD18863.1 - 3.3e-09 37.1 0.3 3.3e-09 37.1 0.3 2.4 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 AMD18863.1 - 0.00014 21.8 0.1 0.001 19.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AMD18863.1 - 0.0011 18.7 0.0 0.0033 17.2 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AMD18863.1 - 0.002 18.5 1.8 0.18 12.2 0.2 3.0 2 1 1 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 AMD18863.1 - 0.0037 16.5 0.9 0.0059 15.8 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_17 PF13207.6 AMD18863.1 - 0.0046 17.4 1.9 0.017 15.5 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_2 PF07724.14 AMD18863.1 - 0.0047 17.1 0.5 0.019 15.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AMD18863.1 - 0.0079 16.5 0.3 0.49 10.7 0.2 3.1 1 1 1 2 2 2 1 AAA domain DUF883 PF05957.13 AMD18863.1 - 0.038 14.6 0.8 0.16 12.6 0.8 2.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) IstB_IS21 PF01695.17 AMD18863.1 - 0.073 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 AMD18863.1 - 0.11 12.8 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain THOC7 PF05615.13 AMD18863.1 - 0.92 9.8 9.3 0.29 11.4 4.7 2.5 2 0 0 2 2 2 0 Tho complex subunit 7 Allexi_40kDa PF05549.11 AMD18863.1 - 5.2 6.5 6.2 0.82 9.1 0.5 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein Macro_2 PF14519.6 AMD18864.1 - 4.3e-61 206.7 0.0 4.9e-61 206.5 0.0 1.0 1 0 0 1 1 1 1 Macro-like domain Aminotran_1_2 PF00155.21 AMD18865.1 - 7.1e-70 236.0 0.0 8.1e-70 235.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Baculo_8kDa PF06096.11 AMD18865.1 - 0.082 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Baculoviridae 8.2 KDa protein SIS PF01380.22 AMD18867.1 - 6.4e-62 207.2 0.3 8.8e-32 109.7 0.3 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 AMD18867.1 - 5.5e-16 59.0 0.0 1.2e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AMD18867.1 - 2.1e-10 40.6 0.0 4.2e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 AMD18867.1 - 4.4e-07 29.1 0.1 7.5e-07 28.3 0.1 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Peptidase_M18 PF02127.15 AMD18868.1 - 4.2e-140 467.4 0.0 5e-140 467.1 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 AMD18868.1 - 1.7e-06 27.3 0.1 0.023 13.7 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase OmpW PF03922.14 AMD18868.1 - 0.062 13.2 0.0 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 OmpW family RHH_6 PF16762.5 AMD18868.1 - 0.22 12.2 1.1 41 4.9 0.0 2.7 2 0 0 2 2 2 0 Ribbon-helix-helix domain Pkinase PF00069.25 AMD18869.1 - 1.6e-73 247.3 0.0 3.1e-73 246.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18869.1 - 4.4e-39 134.3 0.0 9.5e-39 133.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD18869.1 - 0.00033 20.1 0.0 0.00056 19.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AMD18869.1 - 0.0023 17.3 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AMD18869.1 - 0.0024 17.5 0.1 0.015 14.9 0.0 2.3 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 AMD18869.1 - 0.023 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ADH_zinc_N PF00107.26 AMD18870.1 - 1.8e-29 102.4 0.4 3.1e-29 101.6 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AMD18870.1 - 4.7e-29 100.5 0.3 8.1e-29 99.7 0.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AMD18870.1 - 3.1e-13 50.9 0.1 5.2e-13 50.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AMD18870.1 - 0.0014 18.1 0.4 0.0021 17.6 0.4 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus adh_short PF00106.25 AMD18870.1 - 0.077 12.4 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Utp11 PF03998.13 AMD18871.1 - 2e-65 221.1 27.3 2.3e-65 220.9 27.3 1.0 1 0 0 1 1 1 1 Utp11 protein Phage_GPO PF05929.11 AMD18871.1 - 5.7 6.5 10.8 0.12 11.9 3.2 1.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Ku PF02735.16 AMD18873.1 - 4.6e-38 131.0 0.2 1.2e-37 129.6 0.1 1.8 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 AMD18873.1 - 2e-06 27.8 0.1 3.1e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Atg29_N PF18388.1 AMD18873.1 - 0.012 15.4 0.2 0.025 14.4 0.2 1.5 1 0 0 1 1 1 0 Atg29 N-terminal domain PGM_PMM_I PF02878.16 AMD18874.1 - 2.9e-35 121.0 0.2 4.8e-35 120.3 0.2 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 AMD18874.1 - 5.4e-24 84.6 0.0 1.1e-23 83.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 AMD18874.1 - 8.2e-13 48.9 0.0 2.1e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 AMD18874.1 - 9.8e-05 22.5 0.0 0.00024 21.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Endopep_inhib PF16800.5 AMD18874.1 - 0.0088 16.0 3.6 0.34 10.9 0.1 2.6 2 0 0 2 2 2 2 IseA DL-endopeptidase inhibitor Fer4_12 PF13353.6 AMD18874.1 - 0.16 12.3 0.0 0.44 10.8 0.0 1.7 1 0 0 1 1 1 0 4Fe-4S single cluster domain Pkinase PF00069.25 AMD18875.1 - 1.5e-68 231.0 0.0 3.3e-68 229.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18875.1 - 1e-32 113.5 0.0 1.7e-32 112.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 AMD18875.1 - 1.1e-10 42.1 0.3 3.5e-10 40.4 0.3 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 AMD18875.1 - 4e-06 26.0 0.1 4e-06 26.0 0.1 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 AMD18875.1 - 0.0041 16.5 0.0 0.016 14.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 AMD18875.1 - 0.0052 16.4 0.1 1.2 8.7 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 AMD18875.1 - 0.016 14.5 0.3 0.034 13.5 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4169 PF13770.6 AMD18875.1 - 0.027 14.7 0.2 0.056 13.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) APH PF01636.23 AMD18875.1 - 0.051 13.5 0.1 0.094 12.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RRN3 PF05327.11 AMD18876.1 - 2e-178 594.4 11.9 2.4e-178 594.2 11.9 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 RecG_N PF17190.4 AMD18876.1 - 0.29 11.9 0.1 0.29 11.9 0.1 3.6 4 0 0 4 4 4 0 RecG N-terminal helical domain SPRY PF00622.28 AMD18877.1 - 2.4e-11 43.8 0.0 5.2e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 SPRY domain SRP9-21 PF05486.12 AMD18878.1 - 5.8e-20 71.5 0.8 5.8e-20 71.5 0.8 2.4 2 1 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) WD40 PF00400.32 AMD18879.1 - 1.9e-18 66.5 7.1 0.00046 20.9 0.2 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD18879.1 - 0.00042 20.5 0.0 10 6.5 0.0 4.5 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 AMD18879.1 - 0.00065 18.3 0.0 0.0048 15.5 0.0 2.3 2 1 0 2 2 2 1 Cytochrome D1 heme domain ArfGap PF01412.18 AMD18879.1 - 0.087 12.9 0.5 23 5.1 0.1 3.2 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Mito_carr PF00153.27 AMD18880.1 - 1.8e-59 197.7 3.2 2.1e-19 69.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltransf PF01255.19 AMD18881.1 - 7.2e-61 205.6 0.2 1.1e-60 205.0 0.2 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Vma12 PF11712.8 AMD18882.1 - 3.8e-30 104.8 0.0 7e-30 103.9 0.0 1.4 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase FliE PF02049.18 AMD18882.1 - 0.07 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE DUF2339 PF10101.9 AMD18882.1 - 0.091 11.3 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Chordopox_A13L PF05961.11 AMD18882.1 - 0.15 12.3 0.2 0.41 10.9 0.2 1.8 1 0 0 1 1 1 0 Chordopoxvirus A13L protein zf-MYND PF01753.18 AMD18883.1 - 1.3e-05 25.2 24.5 3.8e-05 23.7 24.5 1.8 1 1 0 1 1 1 1 MYND finger Abhydrolase_1 PF00561.20 AMD18884.1 - 6.1e-22 78.5 0.6 8.5e-22 78.0 0.6 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AMD18884.1 - 4.8e-18 66.6 0.4 7.6e-18 65.9 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD18884.1 - 9.7e-12 44.7 0.0 3.9e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 AMD18884.1 - 0.00051 19.8 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Ser_hydrolase PF06821.13 AMD18884.1 - 0.019 14.8 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase AMP-binding PF00501.28 AMD18885.1 - 3.6e-82 276.2 0.1 4.7e-82 275.8 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AMD18885.1 - 0.0066 17.4 0.1 0.041 14.9 0.1 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF3368 PF11848.8 AMD18885.1 - 0.23 11.3 0.7 21 5.0 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) Cauli_VI PF01693.16 AMD18886.1 - 3.3e-26 91.3 7.9 4.9e-14 52.4 0.1 2.9 3 0 0 3 3 3 2 Caulimovirus viroplasmin RNase_H PF00075.24 AMD18886.1 - 9.2e-26 90.7 0.1 2.7e-25 89.2 0.0 1.8 2 0 0 2 2 2 1 RNase H Cu_bind_like PF02298.17 AMD18886.1 - 0.032 14.2 2.1 0.033 14.2 0.4 1.9 2 0 0 2 2 2 0 Plastocyanin-like domain Membr_traf_MHD PF10540.9 AMD18887.1 - 9.6e-46 155.6 0.2 4.3e-45 153.5 0.1 2.2 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 AMD18887.1 - 7.5e-10 39.0 0.2 1.7e-09 37.9 0.2 1.6 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 AMD18887.1 - 1.1e-09 37.5 3.1 1.1e-08 34.2 1.4 2.7 3 0 0 3 3 3 1 Plant family of unknown function (DUF810) SWIB PF02201.18 AMD18888.1 - 2.8e-30 104.0 0.3 2.8e-30 104.0 0.3 2.1 3 0 0 3 3 3 1 SWIB/MDM2 domain DEK_C PF08766.11 AMD18888.1 - 1.2e-09 38.0 0.3 1.6e-08 34.3 0.4 2.6 2 0 0 2 2 2 1 DEK C terminal domain RRS1 PF04939.12 AMD18889.1 - 1.1e-56 191.2 3.7 1.3e-56 190.9 3.7 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) RhoGEF PF00621.20 AMD18890.1 - 6.4e-12 46.1 0.8 6.4e-12 46.1 0.8 3.4 2 2 1 3 3 3 1 RhoGEF domain DUF4793 PF16041.5 AMD18890.1 - 0.55 10.4 6.6 0.65 10.2 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4793) RB_B PF01857.20 AMD18890.1 - 5.5 7.0 9.1 6.2 6.9 2.5 3.9 3 1 0 3 3 3 0 Retinoblastoma-associated protein B domain VPS11_C PF12451.8 AMD18891.1 - 3.8e-09 36.6 0.1 3.8e-09 36.6 0.1 2.5 3 0 0 3 3 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 AMD18891.1 - 1.3e-06 28.4 4.9 5.2e-06 26.4 4.9 2.1 1 1 0 1 1 1 1 Zinc-finger zf-RING_5 PF14634.6 AMD18891.1 - 1e-05 25.4 5.9 2.5e-05 24.1 5.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AMD18891.1 - 3.7e-05 23.5 6.9 0.0001 22.0 6.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD18891.1 - 0.0001 22.2 5.9 0.0001 22.2 4.2 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 AMD18891.1 - 0.00023 21.4 5.6 0.00067 19.9 5.6 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 AMD18891.1 - 0.0012 18.9 4.2 0.0046 17.1 4.2 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 AMD18891.1 - 0.007 16.4 1.7 0.017 15.1 1.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 AMD18891.1 - 0.0072 16.6 3.8 0.023 15.0 3.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 AMD18891.1 - 0.0075 15.9 3.2 0.021 14.5 3.2 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type PHD PF00628.29 AMD18891.1 - 0.014 15.3 4.8 0.014 15.3 4.8 2.5 2 0 0 2 2 2 0 PHD-finger zf-C3HC4 PF00097.25 AMD18891.1 - 0.03 14.2 6.9 0.088 12.7 6.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 AMD18891.1 - 0.3 11.1 2.0 0.85 9.7 2.0 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_11 PF17123.5 AMD18891.1 - 0.38 10.6 6.1 1.2 8.9 6.1 2.0 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 AMD18891.1 - 0.44 10.4 4.8 1 9.2 4.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Ribosomal_L22e PF01776.17 AMD18891.1 - 0.52 10.7 6.1 0.28 11.6 0.7 2.9 3 0 0 3 3 2 0 Ribosomal L22e protein family CDRT4 PF15213.6 AMD18891.1 - 2.2 8.9 5.6 0.36 11.4 0.8 2.1 3 0 0 3 3 1 0 CMT1A duplicated region transcript 4 protein Pkinase PF00069.25 AMD18892.1 - 8.9e-66 221.9 1.4 5e-64 216.2 0.2 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18892.1 - 1e-47 162.6 0.1 8.4e-47 159.6 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 AMD18892.1 - 9.8e-35 118.9 0.1 2.7e-34 117.5 0.1 1.8 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 AMD18892.1 - 1.4e-11 44.3 2.3 1.4e-11 44.3 0.1 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 AMD18892.1 - 2.5e-08 34.2 0.0 9.2e-08 32.4 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 AMD18892.1 - 0.00016 21.1 0.0 0.0018 17.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AMD18892.1 - 0.00048 19.0 0.0 0.0009 18.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase SAM_4 PF18017.1 AMD18892.1 - 0.013 15.5 0.0 0.12 12.3 0.0 2.7 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) AFT PF08731.11 AMD18892.1 - 0.025 14.9 0.9 0.061 13.7 0.9 1.7 1 0 0 1 1 1 0 Transcription factor AFT VPS38 PF17649.1 AMD18894.1 - 2.5e-115 385.8 6.9 2.9e-115 385.6 6.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 38 Bunya_NS-S PF01104.17 AMD18894.1 - 0.012 15.4 0.0 0.04 13.7 0.0 1.9 1 0 0 1 1 1 0 Bunyavirus non-structural protein NS-s IRK_C PF17655.1 AMD18894.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel C-terminal domain Folliculin PF11704.8 AMD18895.1 - 1e-41 142.8 0.1 1.6e-41 142.3 0.1 1.3 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Adeno_E1B_19K PF01691.16 AMD18895.1 - 0.023 14.2 0.1 0.7 9.4 0.0 2.2 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen Lyase_1 PF00206.20 AMD18896.1 - 7.3e-25 88.0 0.0 1.2e-24 87.2 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 AMD18896.1 - 2.9e-18 66.2 0.1 1.3e-17 64.0 0.0 2.2 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.11 AMD18896.1 - 0.066 12.9 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) AsiA PF09010.10 AMD18896.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Anti-Sigma Factor A Bromodomain PF00439.25 AMD18897.1 - 2.7e-30 104.3 4.6 1.7e-16 60.0 0.3 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 AMD18897.1 - 4.1e-24 84.8 0.3 1.3e-23 83.1 0.3 1.9 1 0 0 1 1 1 1 BAH domain SIR2 PF02146.17 AMD18898.1 - 3e-36 125.0 0.0 2.6e-35 122.0 0.0 2.1 1 1 0 1 1 1 1 Sir2 family Zn-ribbon_8 PF09723.10 AMD18898.1 - 0.071 13.2 0.9 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 Zinc ribbon domain Glyco_transf_28 PF03033.20 AMD18898.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain AA_permease_2 PF13520.6 AMD18899.1 - 3e-83 280.0 40.8 3.7e-83 279.7 40.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AMD18899.1 - 4.1e-21 75.1 33.3 7.5e-21 74.3 33.3 1.3 1 0 0 1 1 1 1 Amino acid permease PAP_central PF04928.17 AMD18900.1 - 4.8e-110 366.4 0.0 9.9e-110 365.4 0.0 1.5 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 AMD18900.1 - 5.1e-53 179.2 4.1 9.6e-53 178.3 4.1 1.5 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 AMD18900.1 - 1.2e-13 51.1 0.0 3.5e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 AMD18900.1 - 0.012 15.6 0.0 0.054 13.6 0.0 2.1 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Peptidase_S49 PF01343.18 AMD18900.1 - 0.041 13.8 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 Peptidase family S49 Nrap_D2 PF17403.2 AMD18900.1 - 0.081 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Dynamin_M PF01031.20 AMD18901.1 - 4.6e-97 324.7 0.1 1.5e-96 323.0 0.0 1.9 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 AMD18901.1 - 4.5e-58 196.0 1.0 1.1e-57 194.7 0.1 2.1 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 AMD18901.1 - 4.7e-28 97.2 3.3 4.7e-28 97.2 3.3 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AMD18901.1 - 0.00017 21.6 0.3 0.00088 19.3 0.3 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase HTH_9 PF08221.11 AMD18901.1 - 0.059 13.5 0.5 0.59 10.3 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain APS_kinase PF01583.20 AMD18902.1 - 3.5e-70 234.9 0.0 4.2e-70 234.7 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_16 PF13191.6 AMD18902.1 - 0.0036 17.7 0.0 0.0039 17.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 AMD18902.1 - 0.0043 16.8 0.0 0.0064 16.2 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain KTI12 PF08433.10 AMD18902.1 - 0.0044 16.5 0.0 0.0055 16.2 0.0 1.2 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 AMD18902.1 - 0.0066 17.0 0.0 0.0095 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AMD18902.1 - 0.0073 16.5 0.0 0.016 15.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AMD18902.1 - 0.068 13.7 0.0 0.094 13.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter CPT PF07931.12 AMD18902.1 - 0.072 12.9 0.2 0.33 10.8 0.1 2.2 3 1 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein PRK PF00485.18 AMD18902.1 - 0.094 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.20 AMD18902.1 - 0.17 11.0 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit Snf7 PF03357.21 AMD18903.1 - 3.9e-29 101.4 19.3 4.7e-29 101.2 17.1 1.8 2 0 0 2 2 2 1 Snf7 Ist1 PF03398.14 AMD18903.1 - 3.9e-06 26.9 7.4 5.6e-06 26.4 7.4 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF3958 PF13125.6 AMD18903.1 - 0.42 10.8 9.5 0.29 11.4 4.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) DUF87 PF01935.17 AMD18903.1 - 0.76 9.8 7.2 0.64 10.1 0.2 2.1 1 1 0 2 2 2 0 Helicase HerA, central domain Occludin_ELL PF07303.13 AMD18903.1 - 10 6.9 10.2 8.1 7.2 3.2 3.0 1 1 1 2 2 2 0 Occludin homology domain Ribosomal_S6 PF01250.17 AMD18904.1 - 1.6e-25 89.2 0.1 2.1e-25 88.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 DUF1433 PF07252.11 AMD18904.1 - 0.068 13.4 0.0 0.19 12.0 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1433) PHB_depo_C PF06850.11 AMD18904.1 - 0.13 11.7 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 PHB de-polymerase C-terminus PAP2_3 PF14378.6 AMD18905.1 - 3.6e-27 95.3 11.5 3.6e-27 95.3 11.5 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 AMD18905.1 - 6.8e-11 42.1 6.8 6.8e-11 42.1 6.8 2.3 2 0 0 2 2 2 1 PAP2 superfamily Ribosomal_L14e PF01929.17 AMD18906.1 - 6.7e-32 109.8 0.5 1e-31 109.2 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 AMD18906.1 - 1.6e-05 24.7 0.1 3.1e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 KOW motif F-actin_cap_A PF01267.17 AMD18908.1 - 2.2e-70 237.1 0.4 2.5e-70 237.0 0.4 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit LPD29 PF18847.1 AMD18908.1 - 0.05 14.5 0.1 21 6.1 0.0 2.5 2 0 0 2 2 2 0 Large polyvalent protein associated domain 29 VHS PF00790.19 AMD18909.1 - 7.1e-32 110.2 3.1 1e-31 109.7 0.6 2.5 3 0 0 3 3 3 1 VHS domain SH3_1 PF00018.28 AMD18909.1 - 8.6e-15 54.1 0.0 1.7e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AMD18909.1 - 1.4e-13 50.4 0.1 6.1e-13 48.4 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 AMD18909.1 - 2.7e-13 49.4 0.2 8.5e-13 47.8 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain GAT PF03127.14 AMD18909.1 - 6e-08 32.9 2.0 1.3e-07 31.8 0.9 2.2 2 0 0 2 2 2 1 GAT domain Hrs_helical PF12210.8 AMD18909.1 - 0.92 10.1 8.2 1 9.9 0.2 2.9 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate TRAM_LAG1_CLN8 PF03798.16 AMD18910.1 - 6e-40 137.1 24.2 6e-40 137.1 24.2 2.5 2 1 1 3 3 3 1 TLC domain TRAM1 PF08390.11 AMD18910.1 - 6.7e-22 76.9 0.8 1.6e-21 75.7 0.8 1.7 1 0 0 1 1 1 1 TRAM1-like protein Ribosomal_S2 PF00318.20 AMD18911.1 - 3.1e-68 229.2 0.0 3.6e-67 225.7 0.0 2.2 1 1 0 1 1 1 1 Ribosomal protein S2 RL10P_insert PF17777.1 AMD18913.1 - 1.1e-17 63.8 0.0 1.8e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 AMD18913.1 - 2.3e-17 62.9 0.0 4.1e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 HECT PF00632.25 AMD18914.1 - 1.1e-71 241.8 0.0 2.6e-71 240.6 0.0 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF3361 PF11841.8 AMD18914.1 - 0.016 15.2 3.0 0.18 11.8 0.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) Attractin PF08037.11 AMD18914.1 - 0.26 11.3 1.2 0.65 10.0 1.2 1.6 1 0 0 1 1 1 0 Attractin family Pkinase PF00069.25 AMD18915.1 - 4.1e-73 246.0 0.0 6.4e-73 245.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18915.1 - 1.1e-46 159.2 0.0 1.9e-46 158.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 AMD18915.1 - 1.6e-23 82.8 0.1 4.3e-23 81.4 0.1 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 AMD18915.1 - 1.1e-05 24.9 0.0 1.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AMD18915.1 - 0.13 11.0 15.5 0.034 12.9 10.2 2.4 2 1 0 2 2 2 0 Fungal protein kinase CDC45 PF02724.14 AMD18915.1 - 0.27 9.5 7.5 0.48 8.7 7.5 1.3 1 0 0 1 1 1 0 CDC45-like protein APH PF01636.23 AMD18915.1 - 0.56 10.1 0.0 0.56 10.1 0.0 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family LtuB PF17455.2 AMD18915.1 - 0.73 10.5 0.0 0.73 10.5 0.0 2.2 2 0 0 2 2 2 0 Late transcription unit B DUF2828 PF11443.8 AMD18915.1 - 9.1 4.2 10.6 16 3.4 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CENP-C_C PF11699.8 AMD18916.1 - 2.5e-27 94.9 2.3 5.1e-27 93.9 2.3 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 AMD18916.1 - 8.5e-07 29.8 0.8 8.5e-07 29.8 0.8 2.8 2 1 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 AMD18916.1 - 0.00039 20.1 0.0 0.0008 19.1 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 AMD18916.1 - 0.043 13.4 3.5 0.55 9.8 0.8 2.5 2 0 0 2 2 2 0 Cupin CUE PF02845.16 AMD18917.1 - 8e-10 38.2 0.3 2.9e-06 26.9 0.0 2.5 2 0 0 2 2 2 2 CUE domain Smr PF01713.21 AMD18917.1 - 2.4e-05 24.6 0.0 9.6e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 Smr domain HNH PF01844.23 AMD18918.1 - 0.14 12.3 3.1 0.48 10.6 3.1 1.9 1 0 0 1 1 1 0 HNH endonuclease Aminotran_1_2 PF00155.21 AMD18919.1 - 1e-39 136.8 0.0 2e-39 135.8 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II TetR_C_14 PF17754.1 AMD18919.1 - 0.14 12.1 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 MftR C-terminal domain DnaJ_C PF01556.18 AMD18920.1 - 1.7e-31 109.3 0.0 2.3e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AMD18920.1 - 5.2e-25 87.3 2.0 8.4e-25 86.7 2.0 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AMD18920.1 - 3.2e-11 43.4 9.6 6.2e-11 42.5 9.6 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AMD18920.1 - 5.9e-05 23.0 11.5 0.0046 16.9 1.1 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein zinc_ribbon_6 PF14599.6 AMD18920.1 - 1.4 8.9 10.7 1.6 8.8 2.9 2.7 2 1 0 2 2 2 0 Zinc-ribbon HypA PF01155.19 AMD18920.1 - 1.7 8.7 8.1 16 5.6 0.2 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Securin PF04856.13 AMD18921.1 - 2.9e-21 76.5 17.4 8.2e-21 75.0 17.4 1.7 1 1 0 1 1 1 1 Securin sister-chromatid separation inhibitor GEP5 PF17053.5 AMD18922.1 - 4.2e-51 173.9 3.6 5e-51 173.7 3.6 1.0 1 0 0 1 1 1 1 Genetic interactor of prohibitin 5 Ribosomal_L34 PF00468.17 AMD18923.1 - 1.4e-18 66.6 7.0 1.4e-18 66.6 7.0 1.8 1 1 0 1 1 1 1 Ribosomal protein L34 Ribosomal_L1 PF00687.21 AMD18924.1 - 5.4e-29 101.4 0.2 7.7e-29 100.9 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family SUI1 PF01253.22 AMD18925.1 - 8.8e-19 67.8 0.1 3e-18 66.1 0.1 2.0 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 AMD18925.1 - 1.2e-11 45.1 3.2 1.3e-11 45.0 1.1 2.2 2 0 0 2 2 2 1 Pre-PUA-like domain SWIB PF02201.18 AMD18925.1 - 0.013 15.4 0.0 0.047 13.6 0.0 2.0 1 0 0 1 1 1 0 SWIB/MDM2 domain Kin17_mid PF10357.9 AMD18925.1 - 0.025 14.5 0.2 0.06 13.3 0.2 1.6 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein ANAPC4 PF12896.7 AMD18926.1 - 3.4e-25 88.8 6.2 5e-25 88.2 6.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 Sulfate_transp PF00916.20 AMD18927.1 - 4.8e-114 381.1 15.8 6.2e-114 380.7 15.8 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 AMD18927.1 - 0.00021 20.9 0.0 0.00047 19.8 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 AMD18927.1 - 0.066 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 STAS domain MFS_MOT1 PF16983.5 AMD18927.1 - 8.8 6.8 12.1 0.058 13.8 0.7 2.8 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily MFS_1 PF07690.16 AMD18928.1 - 3e-10 39.6 37.4 5.7e-09 35.4 32.6 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF1467 PF07330.12 AMD18928.1 - 2.8 7.9 5.8 3.2 7.7 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1467) TRM PF02005.16 AMD18930.1 - 4.9e-139 463.7 0.0 6.1e-139 463.4 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 AMD18930.1 - 0.0014 18.5 0.1 0.0026 17.5 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 AMD18930.1 - 0.061 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CBFD_NFYB_HMF PF00808.23 AMD18931.1 - 0.0001 22.5 0.2 0.00026 21.2 0.2 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Nyv1_N PF09426.10 AMD18932.1 - 1.6e-47 161.0 0.6 1.6e-47 161.0 0.6 1.4 2 0 0 2 2 2 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.21 AMD18932.1 - 1.4e-25 88.8 3.9 2.1e-25 88.3 3.9 1.3 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 AMD18932.1 - 0.04 14.0 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter FMO-like PF00743.19 AMD18933.1 - 7.7e-30 103.8 0.1 4.9e-18 64.8 0.3 3.2 1 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 AMD18933.1 - 2.4e-15 56.6 0.1 1.9e-09 37.2 0.0 3.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 AMD18933.1 - 3.3e-11 42.9 0.0 1.5e-08 34.2 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 AMD18933.1 - 4.8e-11 42.4 0.0 4.9e-10 39.1 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AMD18933.1 - 1.3e-08 35.0 0.0 8.5e-08 32.3 0.0 2.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 AMD18933.1 - 3.3e-05 24.0 0.0 0.00013 22.1 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 AMD18933.1 - 4.2e-05 24.0 0.0 0.015 15.9 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AMD18933.1 - 0.0062 15.8 0.0 0.11 11.8 0.0 2.2 2 0 0 2 2 2 1 Thi4 family F420_oxidored PF03807.17 AMD18933.1 - 0.036 14.6 0.1 1.7 9.3 0.0 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DAO PF01266.24 AMD18933.1 - 0.046 13.3 0.0 0.23 11.0 0.0 2.2 3 0 0 3 3 3 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 AMD18933.1 - 0.11 12.6 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 AMD18933.1 - 0.13 12.7 0.0 3 8.3 0.0 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain PHD PF00628.29 AMD18935.1 - 0.0051 16.7 2.1 0.0051 16.7 2.1 2.2 3 0 0 3 3 3 1 PHD-finger zf-CSL PF05207.13 AMD18935.1 - 0.011 15.5 2.2 0.032 13.9 2.2 1.8 1 0 0 1 1 1 0 CSL zinc finger Pkinase PF00069.25 AMD18936.1 - 2.2e-69 233.8 2.6 4.5e-64 216.4 0.1 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18936.1 - 1.9e-40 138.8 0.9 9.8e-39 133.2 0.1 2.3 1 1 1 2 2 2 1 Protein tyrosine kinase KA1 PF02149.19 AMD18936.1 - 8.1e-18 64.0 0.0 1.6e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 AMD18936.1 - 9.5e-07 28.4 0.0 1.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AMD18936.1 - 0.00012 21.5 0.1 0.00026 20.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AMD18936.1 - 0.00089 18.3 1.1 0.0028 16.7 0.1 2.3 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 AMD18936.1 - 0.0011 18.9 0.1 0.19 11.6 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AMD18936.1 - 0.0069 15.2 0.2 0.0069 15.2 0.2 2.5 2 1 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 AMD18936.1 - 0.05 13.2 0.8 0.15 11.6 0.8 1.7 1 1 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 AMD18936.1 - 0.34 10.4 1.7 1.1 8.8 1.7 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL HLH PF00010.26 AMD18937.1 - 0.11 12.5 0.4 0.28 11.2 0.4 1.8 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF2841 PF11001.8 AMD18938.1 - 1.9e-36 124.8 1.1 4.2e-36 123.7 1.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Fungal_trans PF04082.18 AMD18939.1 - 5.4e-37 127.3 0.9 1.1e-36 126.2 0.9 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD18939.1 - 2.5e-09 37.1 11.5 4.1e-09 36.4 11.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nuc_recep-AF1 PF11825.8 AMD18939.1 - 0.0041 17.2 3.5 0.0087 16.1 3.5 1.5 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 DUF4377 PF14302.6 AMD18939.1 - 0.066 13.3 0.1 25 5.0 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4377) DHHC PF01529.20 AMD18941.1 - 7.9e-24 84.3 15.6 7.9e-24 84.3 15.6 3.1 2 2 0 2 2 2 1 DHHC palmitoyltransferase EPSP_synthase PF00275.20 AMD18942.1 - 1.9e-134 448.5 0.0 2.5e-134 448.1 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 AMD18942.1 - 2.4e-101 338.3 0.0 3.8e-101 337.7 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 AMD18942.1 - 1.2e-56 192.6 0.0 9.5e-56 189.6 0.0 2.3 2 0 0 2 2 2 1 Type I 3-dehydroquinase SKI PF01202.22 AMD18942.1 - 3.2e-35 121.6 0.1 7.2e-34 117.2 0.0 2.4 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 AMD18942.1 - 2e-21 76.0 0.0 7.3e-21 74.2 0.0 2.1 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 AMD18942.1 - 4.2e-11 42.4 0.0 9.6e-11 41.3 0.0 1.7 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 AMD18942.1 - 4.5e-08 33.3 0.0 1.4e-07 31.6 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.6 AMD18942.1 - 4.2e-07 29.9 0.0 1.1e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase AAA_33 PF13671.6 AMD18942.1 - 0.0003 21.0 0.0 0.00098 19.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain Fe-ADH PF00465.19 AMD18942.1 - 0.016 14.1 0.2 0.22 10.3 0.1 2.3 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase AAA_14 PF13173.6 AMD18942.1 - 0.18 11.9 0.0 0.62 10.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain Zn_ribbon_17 PF17120.5 AMD18943.1 - 7.2e-19 67.2 13.9 1.5e-18 66.1 13.9 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AMD18943.1 - 8.4e-08 32.8 17.8 0.016 16.1 0.1 6.1 5 0 0 5 5 5 3 WD domain, G-beta repeat RWD PF05773.22 AMD18943.1 - 0.0033 17.7 0.1 0.018 15.4 0.0 2.2 2 0 0 2 2 2 1 RWD domain zf-RING_2 PF13639.6 AMD18943.1 - 0.0092 16.3 7.6 0.028 14.7 7.6 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AMD18943.1 - 0.25 11.7 13.6 0.096 13.0 10.3 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain C1_2 PF03107.16 AMD18943.1 - 0.69 10.3 7.2 1.9 8.9 7.2 1.8 1 0 0 1 1 1 0 C1 domain zf-C3HC4_2 PF13923.6 AMD18943.1 - 1.9 8.4 7.3 6.9 6.6 6.8 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) adh_short PF00106.25 AMD18944.1 - 0.0014 18.1 0.0 0.0034 16.9 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase CH PF00307.31 AMD18945.1 - 2.3e-78 259.5 0.0 2.5e-20 72.7 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 AMD18945.1 - 1e-05 25.8 0.2 4.7e-05 23.7 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 AMD18945.1 - 0.0011 18.3 1.9 1.2 8.8 0.1 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 AMD18945.1 - 0.079 12.9 1.7 0.71 10.0 0.1 3.0 2 1 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.6 AMD18945.1 - 0.12 12.3 0.1 7.3 6.5 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair ANAPC9 PF12856.7 AMD18946.1 - 1.1e-06 28.9 0.0 1.9e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 CDC45 PF02724.14 AMD18947.1 - 6.2e-192 639.3 0.0 1.1e-191 638.5 0.0 1.4 1 1 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 AMD18947.1 - 1.3 9.1 4.9 1.9 8.5 4.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF2933 PF11666.8 AMD18948.1 - 0.0068 16.4 1.0 0.01 15.8 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2933) tRNA_int_endo PF01974.17 AMD18949.1 - 5.3e-24 84.1 0.0 9.7e-24 83.3 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 AMD18949.1 - 0.036 13.7 0.1 0.4 10.4 0.1 2.3 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain AAA_5 PF07728.14 AMD18950.1 - 7.3e-128 421.2 0.5 3.2e-21 75.8 0.0 9.6 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 AMD18950.1 - 1.8e-51 172.7 1.8 5.7e-21 74.7 0.0 4.9 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 AMD18950.1 - 4.6e-32 110.3 0.2 1.7e-28 98.7 0.1 4.5 3 0 0 3 3 3 1 Midasin AAA lid domain AAA_3 PF07726.11 AMD18950.1 - 5.8e-31 107.1 0.0 1.2e-10 41.4 0.0 7.6 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 AMD18950.1 - 1.6e-30 106.0 11.9 4.8e-06 26.2 0.9 7.3 6 1 0 6 6 6 5 P-loop containing dynein motor region AAA PF00004.29 AMD18950.1 - 2.4e-30 105.7 1.8 4e-05 24.0 0.0 7.6 7 0 0 7 7 6 6 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AMD18950.1 - 3.2e-22 79.7 7.6 0.002 18.5 0.3 8.5 6 2 0 6 6 6 4 AAA ATPase domain Dynein_heavy PF03028.15 AMD18950.1 - 1.7e-20 73.3 0.0 0.00019 21.5 0.0 8.4 8 0 0 8 8 7 3 Dynein heavy chain region D6 P-loop domain AAA_18 PF13238.6 AMD18950.1 - 8.4e-19 68.4 3.6 0.025 15.1 0.0 8.4 7 0 0 7 7 6 3 AAA domain Sigma54_activat PF00158.26 AMD18950.1 - 3e-18 66.1 0.4 0.0084 15.8 0.1 6.6 6 0 0 6 6 6 4 Sigma-54 interaction domain AAA_22 PF13401.6 AMD18950.1 - 7e-18 65.2 1.1 0.011 15.9 0.0 7.4 6 0 0 6 6 6 4 AAA domain AAA_30 PF13604.6 AMD18950.1 - 1.8e-17 63.7 0.2 0.053 13.2 0.5 7.4 6 1 0 6 6 6 4 AAA domain AAA_14 PF13173.6 AMD18950.1 - 3.1e-17 62.8 0.1 0.04 13.9 0.0 7.4 7 0 0 7 7 6 4 AAA domain AAA_6 PF12774.7 AMD18950.1 - 7.9e-17 61.2 2.3 0.023 13.7 0.1 8.8 9 1 0 9 9 8 5 Hydrolytic ATP binding site of dynein motor region ABC_tran PF00005.27 AMD18950.1 - 1.3e-15 58.1 12.6 0.001 19.6 0.0 7.7 7 0 0 7 7 6 3 ABC transporter TsaE PF02367.17 AMD18950.1 - 6.7e-15 55.2 2.7 0.095 12.7 0.1 6.8 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 AMD18950.1 - 7.6e-15 55.2 3.0 0.0079 16.3 0.1 7.0 7 0 0 7 7 6 3 Sigma-54 interaction domain AAA_33 PF13671.6 AMD18950.1 - 1.1e-11 45.1 0.4 0.34 11.1 0.1 6.3 6 0 0 6 6 6 2 AAA domain RNA_helicase PF00910.22 AMD18950.1 - 1.3e-11 44.8 8.4 1.5 9.2 0.0 8.6 8 0 0 8 8 8 3 RNA helicase T2SSE PF00437.20 AMD18950.1 - 2e-11 43.5 6.4 0.043 12.9 0.0 6.3 6 0 0 6 6 6 3 Type II/IV secretion system protein RsgA_GTPase PF03193.16 AMD18950.1 - 2e-11 44.1 8.7 0.34 10.8 1.0 6.4 6 0 0 6 6 6 4 RsgA GTPase AAA_19 PF13245.6 AMD18950.1 - 9.3e-11 42.2 0.4 0.45 10.9 0.0 6.5 5 0 0 5 5 5 2 AAA domain Zeta_toxin PF06414.12 AMD18950.1 - 3.1e-10 39.7 6.2 0.6 9.4 0.0 7.9 8 0 0 8 8 7 2 Zeta toxin AAA_29 PF13555.6 AMD18950.1 - 6.7e-10 38.6 2.3 1.9 8.3 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 AMD18950.1 - 1.2e-09 37.9 3.0 4.9 6.5 0.0 8.3 8 1 0 9 9 9 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 AMD18950.1 - 1.2e-09 38.1 6.9 0.11 12.2 0.0 6.8 7 0 0 7 7 6 2 SRP54-type protein, GTPase domain AAA_25 PF13481.6 AMD18950.1 - 1.3e-09 37.9 1.3 0.87 9.1 0.0 6.0 6 0 0 6 6 5 1 AAA domain NACHT PF05729.12 AMD18950.1 - 1.8e-09 37.7 5.2 0.61 10.0 0.1 6.4 5 0 0 5 5 5 2 NACHT domain IstB_IS21 PF01695.17 AMD18950.1 - 6.2e-09 35.8 0.2 0.37 10.5 0.0 5.9 6 0 0 6 6 6 2 IstB-like ATP binding protein RuvB_N PF05496.12 AMD18950.1 - 6.7e-09 35.7 5.8 0.11 12.2 0.0 5.8 7 0 0 7 7 5 3 Holliday junction DNA helicase RuvB P-loop domain PduV-EutP PF10662.9 AMD18950.1 - 2.7e-08 33.6 5.4 0.052 13.3 0.0 5.6 6 0 0 6 6 5 3 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 AMD18950.1 - 3.2e-08 33.2 3.4 0.005 16.3 0.1 5.7 6 0 0 6 6 6 2 Bacterial TniB protein PhoH PF02562.16 AMD18950.1 - 4.6e-08 32.8 2.6 0.77 9.2 0.0 5.5 5 0 0 5 5 5 2 PhoH-like protein DUF815 PF05673.13 AMD18950.1 - 9.9e-08 31.4 1.3 0.16 11.1 0.1 5.2 5 0 0 5 5 5 1 Protein of unknown function (DUF815) Rad17 PF03215.15 AMD18950.1 - 2e-07 31.1 8.5 2.2 8.1 0.1 7.4 8 0 0 8 8 6 1 Rad17 P-loop domain Roc PF08477.13 AMD18950.1 - 2.6e-07 30.9 5.8 2.5 8.3 0.0 7.1 8 0 0 8 8 6 1 Ras of Complex, Roc, domain of DAPkinase KAP_NTPase PF07693.14 AMD18950.1 - 2.8e-07 30.1 0.5 2 7.6 0.0 5.1 5 0 0 5 5 4 2 KAP family P-loop domain MMR_HSR1 PF01926.23 AMD18950.1 - 8.7e-07 29.0 1.4 7.2 6.7 0.0 6.1 5 0 0 5 5 5 0 50S ribosome-binding GTPase MCM PF00493.23 AMD18950.1 - 3e-06 26.5 0.3 1.1 8.4 0.0 5.1 5 0 0 5 5 5 2 MCM P-loop domain AAA_28 PF13521.6 AMD18950.1 - 7.2e-06 26.3 15.8 1.1 9.5 0.0 7.7 8 0 0 8 8 7 1 AAA domain AAA_24 PF13479.6 AMD18950.1 - 9.7e-06 25.4 7.0 6.7 6.4 0.1 6.7 7 0 0 7 7 7 0 AAA domain ATP-synt_ab PF00006.25 AMD18950.1 - 3.8e-05 23.5 0.0 0.86 9.2 0.0 4.1 3 1 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain SRPRB PF09439.10 AMD18950.1 - 6.3e-05 22.5 2.7 9.3 5.6 0.1 6.4 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit VWA PF00092.28 AMD18950.1 - 0.00089 19.5 0.4 0.005 17.1 0.4 2.4 1 0 0 1 1 1 1 von Willebrand factor type A domain ATP_bind_1 PF03029.17 AMD18950.1 - 0.0017 18.2 11.5 7.1 6.3 0.3 6.3 6 0 0 6 6 6 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 AMD18950.1 - 0.0026 17.7 14.3 1.6 8.7 0.3 6.7 7 0 0 7 7 6 1 NTPase Thymidylate_kin PF02223.17 AMD18950.1 - 0.0061 16.3 0.1 1.1 8.9 0.0 3.9 3 0 0 3 3 3 1 Thymidylate kinase MobB PF03205.14 AMD18950.1 - 0.075 12.9 6.1 12 5.8 0.0 4.5 5 0 0 5 5 3 0 Molybdopterin guanine dinucleotide synthesis protein B CPT PF07931.12 AMD18950.1 - 0.076 12.9 0.9 30 4.4 0.0 5.4 5 1 0 5 5 5 0 Chloramphenicol phosphotransferase-like protein dNK PF01712.19 AMD18950.1 - 0.11 12.3 7.9 31 4.3 0.0 6.0 6 0 0 6 6 5 0 Deoxynucleoside kinase FeoB_N PF02421.18 AMD18950.1 - 0.22 11.0 3.6 35 3.9 0.0 4.8 4 0 0 4 4 4 0 Ferrous iron transport protein B F-box-like_2 PF13013.6 AMD18950.1 - 0.28 11.2 1.6 0.8 9.7 0.1 2.6 2 0 0 2 2 1 0 F-box-like domain ResIII PF04851.15 AMD18950.1 - 6.3 6.8 26.0 0.26 11.3 0.0 6.7 8 0 0 8 8 6 0 Type III restriction enzyme, res subunit RNase_T PF00929.24 AMD18951.1 - 0.0062 17.1 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 Exonuclease KIX_2 PF16987.5 AMD18951.1 - 0.018 15.0 0.5 0.29 11.1 0.1 2.4 2 0 0 2 2 2 0 KIX domain CHORD PF04968.12 AMD18951.1 - 0.91 10.3 8.5 0.27 12.0 3.7 2.3 2 0 0 2 2 2 0 CHORD FIN1 PF17300.2 AMD18952.1 - 4.4e-46 157.4 13.1 5.3e-46 157.1 13.1 1.0 1 0 0 1 1 1 1 Filaments in between nuclei protein-1 BTB_2 PF02214.22 AMD18953.1 - 1.8e-08 34.6 0.1 9.7e-05 22.6 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain Redoxin PF08534.10 AMD18954.1 - 2.1e-31 108.6 0.1 2.4e-31 108.4 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 AMD18954.1 - 2.3e-09 37.2 0.0 3e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Hydrolase PF00702.26 AMD18954.1 - 0.054 13.8 0.0 0.072 13.4 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Flocculin_t3 PF13928.6 AMD18955.1 - 6.4e-14 52.2 17.7 6.4e-14 52.2 17.7 2.2 2 0 0 2 2 2 1 Flocculin type 3 repeat Pkinase PF00069.25 AMD18956.1 - 1.2e-66 224.8 0.1 2.4e-66 223.8 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD18956.1 - 7.5e-32 110.6 0.0 1.5e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD18956.1 - 3.4e-06 26.3 1.3 4.1e-06 26.0 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 AMD18956.1 - 9.5e-05 21.8 0.2 0.00042 19.7 0.2 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD18956.1 - 0.00047 20.2 3.4 0.0016 18.5 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 AMD18956.1 - 0.019 14.6 0.3 0.059 13.0 0.0 1.9 2 0 0 2 2 2 0 RIO1 family FTA2 PF13095.6 AMD18956.1 - 0.052 13.2 5.6 0.077 12.6 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 AMD18956.1 - 0.057 12.7 4.1 0.17 11.2 0.0 3.0 4 0 0 4 4 4 0 Kinase-like ABC_membrane PF00664.23 AMD18957.1 - 3.6e-87 292.5 45.7 1.1e-49 169.5 18.1 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 AMD18957.1 - 1.8e-48 164.5 0.0 7.2e-28 97.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 AMD18957.1 - 1.9e-09 37.3 3.8 0.00089 18.8 0.1 4.1 2 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 AMD18957.1 - 4e-06 26.9 0.5 0.032 14.3 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 AMD18957.1 - 4.3e-05 23.2 0.1 0.18 11.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 AMD18957.1 - 0.00055 20.4 0.2 1.7 9.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain 60KD_IMP PF02096.20 AMD18957.1 - 0.0012 18.8 0.4 0.0012 18.8 0.4 3.9 3 2 0 4 4 4 1 60Kd inner membrane protein DUF87 PF01935.17 AMD18957.1 - 0.0018 18.4 5.4 0.16 12.0 0.0 3.0 3 0 0 3 3 2 2 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 AMD18957.1 - 0.0026 16.7 0.6 0.063 12.2 0.1 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 AMD18957.1 - 0.0031 17.6 0.2 0.17 11.9 0.0 2.6 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 AMD18957.1 - 0.0032 17.4 0.0 1.7 8.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 AMD18957.1 - 0.0047 16.8 0.4 1.9 8.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AMD18957.1 - 0.0048 16.7 0.3 0.52 10.0 0.0 2.9 3 1 0 3 3 3 1 AAA ATPase domain AAA_7 PF12775.7 AMD18957.1 - 0.0055 16.2 0.1 0.56 9.7 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_23 PF13476.6 AMD18957.1 - 0.0089 16.6 1.9 4.6 7.7 0.0 3.3 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 AMD18957.1 - 0.0097 15.7 0.5 3.8 7.2 0.0 3.0 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_22 PF13401.6 AMD18957.1 - 0.014 15.6 1.3 3.4 7.9 0.1 2.8 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 AMD18957.1 - 0.022 14.7 0.9 12 5.9 0.0 4.0 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 AMD18957.1 - 0.023 14.3 0.1 2.1 7.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 AMD18957.1 - 0.036 13.8 1.7 8.6 6.0 0.4 2.9 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 AMD18957.1 - 0.046 12.8 0.0 0.94 8.5 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 AMD18957.1 - 0.077 12.3 0.1 3.1 7.0 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin Roc PF08477.13 AMD18957.1 - 0.09 13.0 0.5 26 5.1 0.0 3.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 AMD18957.1 - 0.19 11.3 0.3 3.6 7.2 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NESP55 PF06390.12 AMD18957.1 - 2.4 7.7 5.3 0.47 10.0 1.7 1.6 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) ENTH PF01417.20 AMD18958.1 - 9.7e-31 106.4 0.3 1.6e-30 105.7 0.3 1.4 1 0 0 1 1 1 1 ENTH domain RWD PF05773.22 AMD18959.1 - 8.8e-21 74.3 0.3 1.8e-20 73.3 0.3 1.5 1 1 0 1 1 1 1 RWD domain DFRP_C PF16543.5 AMD18959.1 - 1.7e-05 25.2 2.2 3.6e-05 24.2 1.7 1.8 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 AMD18960.1 - 2.8e-20 71.7 18.1 3.5e-10 39.5 2.6 2.2 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AMD18960.1 - 2.2e-07 30.7 20.4 0.00021 21.2 3.2 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 AMD18960.1 - 0.011 15.6 16.9 0.062 13.1 8.6 2.3 2 0 0 2 2 2 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 AMD18960.1 - 0.012 16.1 13.8 0.037 14.5 1.3 2.3 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Mcp5_PH PF12814.7 AMD18961.1 - 3.6e-42 143.3 0.0 8.2e-42 142.2 0.0 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology DUF5615 PF18480.1 AMD18961.1 - 0.0022 17.7 0.1 7.7 6.3 0.0 5.5 4 0 0 4 4 4 1 Domain of unknown function (DUF5615) DUF4256 PF14066.6 AMD18961.1 - 0.016 14.9 13.9 2.5 7.8 0.1 8.8 7 2 1 8 8 8 0 Protein of unknown function (DUF4256) HTH_3 PF01381.22 AMD18961.1 - 0.026 14.6 2.8 35 4.5 0.0 7.3 8 1 1 9 9 9 0 Helix-turn-helix PH PF00169.29 AMD18961.1 - 0.034 14.6 0.0 0.15 12.6 0.0 2.2 1 0 0 1 1 1 0 PH domain DUF1829 PF08862.10 AMD18961.1 - 0.069 13.6 0.3 2.8 8.5 0.0 4.1 3 0 0 3 3 2 0 Domain of unknown function DUF1829 DUF2584 PF10763.9 AMD18961.1 - 0.1 12.8 1.0 1.1 9.5 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2584) HTH_37 PF13744.6 AMD18961.1 - 0.16 12.0 1.1 7.6 6.6 0.0 3.7 3 0 0 3 3 3 0 Helix-turn-helix domain MbeD_MobD PF04899.12 AMD18961.1 - 0.36 11.0 6.9 4.8 7.4 0.4 3.4 2 0 0 2 2 2 0 MbeD/MobD like DUF1664 PF07889.12 AMD18961.1 - 2.6 8.1 7.0 23 5.0 5.6 3.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) ZapB PF06005.12 AMD18961.1 - 3.1 8.3 38.8 0.0063 16.9 8.0 6.8 4 1 0 4 4 3 0 Cell division protein ZapB Slx4 PF09494.10 AMD18962.1 - 1.1e-10 41.3 0.0 3.4e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 Slx4 endonuclease ESP PF16590.5 AMD18962.1 - 0.13 12.5 4.9 0.085 13.1 1.6 2.4 2 0 0 2 2 2 0 Exocrine gland-secreting peptide FlpD PF02662.16 AMD18962.1 - 0.16 12.0 0.3 1.5 8.9 0.2 2.3 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit TMPIT PF07851.13 AMD18962.1 - 1.4 8.1 9.2 6.4 5.9 0.1 2.1 2 0 0 2 2 2 0 TMPIT-like protein SesA PF17107.5 AMD18962.1 - 1.5 9.0 8.4 2.6 8.2 2.1 3.8 3 1 0 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases IZUMO PF15005.6 AMD18962.1 - 3.5 8.1 7.1 2 8.9 3.6 2.3 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Occludin_ELL PF07303.13 AMD18962.1 - 4.3 8.1 8.1 12 6.7 4.6 2.6 2 0 0 2 2 2 0 Occludin homology domain 2-oxoacid_dh PF00198.23 AMD18963.1 - 1.6e-79 266.7 0.1 2.1e-79 266.3 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AMD18963.1 - 1.7e-15 56.6 0.4 3.1e-15 55.8 0.4 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 AMD18963.1 - 0.00011 22.8 0.2 0.007 17.1 0.1 2.5 1 1 1 2 2 2 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 AMD18963.1 - 0.00016 21.4 0.3 0.004 16.9 0.1 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 AMD18963.1 - 0.00017 21.5 0.1 0.00037 20.4 0.1 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein CARMIL_C PF16000.5 AMD18963.1 - 0.0017 18.1 3.3 0.0026 17.4 3.3 1.3 1 0 0 1 1 1 1 CARMIL C-terminus RnfC_N PF13375.6 AMD18963.1 - 0.0032 17.4 0.1 0.02 14.8 0.0 2.1 1 1 1 2 2 2 1 RnfC Barrel sandwich hybrid domain ATP-synt_ab_Xtn PF16886.5 AMD18963.1 - 0.11 12.4 0.1 0.31 10.9 0.1 1.7 1 0 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension Choline_kinase PF01633.20 AMD18964.1 - 4.9e-62 209.3 0.0 6.7e-62 208.8 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 AMD18964.1 - 1.2e-12 47.3 1.8 5.8e-12 45.1 0.1 2.9 4 0 0 4 4 4 1 Choline kinase N terminus APH PF01636.23 AMD18964.1 - 5.7e-07 29.7 0.0 0.00058 19.8 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family HVSL PF09749.9 AMD18965.1 - 1.3e-11 44.4 0.1 2.3e-11 43.6 0.1 1.3 1 1 0 1 1 1 1 Uncharacterised conserved protein DUF5315 PF17242.2 AMD18965.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 1 1 0 1 1 1 0 Disordered region of unknown function (DUF5315) zf-C2H2 PF00096.26 AMD18966.1 - 9e-09 35.3 14.6 0.0014 18.9 2.2 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD18966.1 - 9.6e-06 26.0 11.1 0.088 13.7 1.1 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AMD18966.1 - 0.019 15.4 0.2 0.019 15.4 0.2 3.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 AMD18966.1 - 0.022 14.7 5.5 0.93 9.6 0.0 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-TRAF PF02176.18 AMD18966.1 - 0.023 15.4 0.9 0.023 15.4 0.9 1.9 1 1 1 2 2 2 0 TRAF-type zinc finger zf-C2H2_8 PF15909.5 AMD18966.1 - 0.11 12.8 1.9 0.67 10.3 0.8 2.2 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 AMD18966.1 - 1.6 9.1 4.8 27 5.2 0.0 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AT_hook PF02178.19 AMD18966.1 - 2 8.5 6.8 7.9 6.7 6.8 2.0 1 0 0 1 1 1 0 AT hook motif zf_ZIC PF18366.1 AMD18966.1 - 9.3 6.4 7.0 61 3.8 0.1 4.2 3 1 0 4 4 4 0 Zic proteins zinc finger domain WD40 PF00400.32 AMD18967.1 - 7.8e-48 159.5 27.1 7.7e-07 29.7 0.1 11.3 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD18967.1 - 1.3e-16 60.6 6.7 0.029 14.6 0.0 9.1 2 2 6 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 AMD18967.1 - 1.2e-14 54.6 0.1 2.6e-14 53.4 0.1 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 AMD18967.1 - 4.5e-09 36.1 2.9 0.0082 15.5 0.1 4.0 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 AMD18967.1 - 3.5e-07 29.2 11.8 0.034 12.8 0.5 5.4 4 3 0 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 AMD18967.1 - 1.1e-05 25.5 5.4 1.7 8.5 0.0 5.7 2 2 3 6 6 6 2 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 AMD18967.1 - 0.0008 18.4 6.9 4.3 6.2 0.0 5.3 5 1 1 6 6 6 2 Partner and localizer of BRCA2 WD40 domain ELYS-bb PF16687.5 AMD18967.1 - 0.0027 16.4 0.0 0.039 12.6 0.0 2.3 2 0 0 2 2 2 1 beta-propeller of ELYS nucleoporin CDtoxinA PF03498.14 AMD18967.1 - 0.014 15.0 0.1 0.65 9.6 0.0 2.8 2 0 0 2 2 2 0 Cytolethal distending toxin A/C domain Hira PF07569.11 AMD18967.1 - 0.021 14.6 9.5 1.9 8.2 0.0 4.3 4 0 0 4 4 4 0 TUP1-like enhancer of split TFIID_20kDa PF03847.13 AMD18968.1 - 4e-32 110.5 0.6 4e-32 110.5 0.6 1.7 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.15 AMD18968.1 - 0.008 16.2 0.0 0.008 16.2 0.0 2.4 3 1 0 3 3 3 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 AMD18968.1 - 0.0098 16.3 0.0 0.0098 16.3 0.0 3.8 4 1 0 4 4 4 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AMD18968.1 - 0.058 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Fzo_mitofusin PF04799.13 AMD18968.1 - 0.18 11.3 2.4 0.49 9.9 2.4 1.7 1 0 0 1 1 1 0 fzo-like conserved region Cullin_binding PF03556.15 AMD18969.1 - 5.6e-30 104.2 5.2 5.6e-30 104.2 5.2 2.0 2 1 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 AMD18969.1 - 6.7e-10 38.6 0.1 1.9e-09 37.2 0.1 1.8 1 0 0 1 1 1 1 UBA-like domain Cullin PF00888.22 AMD18970.1 - 9.4e-12 44.3 1.8 1.7e-11 43.5 1.0 1.8 1 1 0 1 1 1 1 Cullin family Pro_isomerase PF00160.21 AMD18971.1 - 5.1e-49 166.6 0.0 5.7e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 AMD18971.1 - 0.049 13.7 0.1 0.53 10.4 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin domain Rgp1 PF08737.10 AMD18972.1 - 7.8e-78 262.5 5.2 1.5e-77 261.6 4.1 1.8 2 0 0 2 2 2 1 Rgp1 Arrestin_C PF02752.22 AMD18972.1 - 0.00067 20.1 2.1 1.1 9.7 0.5 3.8 4 1 0 4 4 4 2 Arrestin (or S-antigen), C-terminal domain Avl9 PF09794.9 AMD18973.1 - 9.3e-148 491.9 3.3 1.2e-147 491.6 3.3 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 AMD18973.1 - 5.3e-10 39.3 2.7 6.5e-09 35.8 2.7 2.4 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 AMD18973.1 - 1.8e-08 34.3 0.1 2.5e-05 24.2 0.0 2.7 2 0 0 2 2 2 2 Stabilization of polarity axis DENN PF02141.21 AMD18973.1 - 0.0044 17.0 1.7 1.3 8.9 0.6 2.7 2 1 1 3 3 3 2 DENN (AEX-3) domain Afi1 PF07792.12 AMD18973.1 - 0.0047 17.4 0.4 0.015 15.8 0.0 2.0 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking efThoc1 PF11957.8 AMD18974.1 - 1.1e-81 275.0 17.1 1.1e-81 275.0 17.1 1.5 2 0 0 2 2 2 1 THO complex subunit 1 transcription elongation factor HPS6 PF15702.5 AMD18974.1 - 0.072 11.1 0.1 0.17 9.8 0.0 1.5 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 6 protein Lactamase_B_6 PF16661.5 AMD18975.1 - 3.8e-71 238.5 0.0 6.5e-71 237.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 AMD18975.1 - 1.4e-24 87.1 0.6 3.2e-21 76.3 0.1 2.6 1 1 1 2 2 2 2 Cleavage and polyadenylation factor 2 C-terminal RMMBL PF07521.12 AMD18975.1 - 0.0045 16.9 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain SF1-HH PF16275.5 AMD18976.1 - 1.6e-40 137.9 3.2 3e-40 137.1 3.2 1.5 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 AMD18976.1 - 9.2e-07 28.6 0.0 2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 AMD18976.1 - 0.00043 20.2 10.3 0.0099 15.9 1.2 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 AMD18976.1 - 0.004 17.1 1.2 1.2 9.2 0.0 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 AMD18976.1 - 0.011 15.6 10.9 0.097 12.5 0.2 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 AMD18976.1 - 0.013 15.3 2.7 1.2 8.9 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 AMD18976.1 - 0.015 15.0 6.4 0.48 10.2 0.7 2.3 2 0 0 2 2 2 0 C2H2 zinc-finger UPF0167 PF03691.14 AMD18976.1 - 0.19 11.5 0.1 0.31 10.8 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) zf-CCHC_5 PF14787.6 AMD18976.1 - 0.33 10.7 0.1 0.33 10.7 0.1 2.7 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger Suf PF05843.14 AMD18977.1 - 5.4e-12 46.3 17.0 0.0098 15.9 0.3 6.3 3 2 1 4 4 4 4 Suppressor of forked protein (Suf) TPR_14 PF13428.6 AMD18977.1 - 1.2e-11 44.4 7.4 0.21 12.5 0.2 8.3 6 1 2 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 AMD18977.1 - 8.3e-09 35.8 0.2 0.056 13.9 0.0 4.5 4 1 2 6 6 6 4 Tetratricopeptide repeat HAT PF02184.16 AMD18977.1 - 2.1e-07 30.7 41.8 0.005 16.8 1.4 9.8 10 1 0 10 10 10 5 HAT (Half-A-TPR) repeat TPR_17 PF13431.6 AMD18977.1 - 9.7e-05 22.5 0.3 0.013 15.8 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat U3_assoc_6 PF08640.11 AMD18977.1 - 0.0012 18.9 13.9 0.022 14.8 1.6 5.4 4 1 1 5 5 5 1 U3 small nucleolar RNA-associated protein 6 TPR_15 PF13429.6 AMD18977.1 - 0.0019 17.5 5.4 0.042 13.1 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD18977.1 - 0.047 13.8 19.8 18 5.7 0.1 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 AMD18977.1 - 0.55 10.9 4.2 18 6.1 0.3 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat ubiquitin PF00240.23 AMD18978.1 - 1.5e-22 79.1 0.2 1.6e-22 79.0 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AMD18978.1 - 6.5e-14 51.5 0.0 7.1e-14 51.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 AMD18978.1 - 0.0013 18.6 0.0 0.0015 18.4 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 AMD18978.1 - 0.0068 16.8 0.0 0.017 15.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AMD18978.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like MTS PF05175.14 AMD18979.1 - 5.7e-06 26.0 0.0 1.1e-05 25.1 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 AMD18979.1 - 0.0016 18.2 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD18979.1 - 0.0058 16.5 0.0 0.024 14.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AMD18979.1 - 0.022 14.2 0.0 0.044 13.2 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 AMD18979.1 - 0.046 14.4 0.0 0.087 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 AMD18979.1 - 0.16 12.6 0.0 0.5 11.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Dopey_N PF04118.14 AMD18980.1 - 2.3e-110 368.5 4.5 2.3e-110 368.5 4.5 2.9 3 0 0 3 3 3 2 Dopey, N-terminal Mod_r PF07200.13 AMD18981.1 - 1.2e-17 64.3 13.9 1.8e-17 63.8 13.9 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein DUF1027 PF06265.11 AMD18981.1 - 0.0078 16.2 2.0 0.015 15.3 2.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1027) SOGA PF11365.8 AMD18981.1 - 0.021 15.9 2.3 0.021 15.9 2.3 1.8 2 1 0 2 2 2 0 Protein SOGA HIP1_clath_bdg PF16515.5 AMD18981.1 - 1.1 9.9 9.2 2.1 9.0 7.1 2.3 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 LMBR1 PF04791.16 AMD18981.1 - 2.7 6.8 4.1 3 6.6 0.2 1.8 1 1 0 1 1 1 0 LMBR1-like membrane protein SLATT_5 PF18160.1 AMD18981.1 - 3.2 7.0 7.7 11 5.3 7.7 1.9 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 WD40 PF00400.32 AMD18982.1 - 8.6e-16 58.1 11.6 0.0045 17.8 0.2 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat zf-RING_2 PF13639.6 AMD18983.1 - 1.2e-10 41.5 7.6 3.4e-09 36.9 2.9 2.3 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 AMD18983.1 - 5.1e-07 29.4 6.9 7e-07 29.0 2.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AMD18983.1 - 5.2e-07 29.9 5.3 1.1e-06 28.8 1.9 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 AMD18983.1 - 1.3e-06 28.2 0.7 1.3e-06 28.2 0.7 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 AMD18983.1 - 5.1e-06 26.3 4.9 8e-06 25.6 1.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD18983.1 - 3e-05 24.0 8.3 6.2e-05 22.9 1.8 2.8 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AMD18983.1 - 3.7e-05 23.5 4.0 8.6e-05 22.3 1.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AMD18983.1 - 0.00018 21.6 1.5 0.00018 21.6 1.5 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 AMD18983.1 - 0.0048 16.8 5.5 0.0052 16.7 1.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 AMD18983.1 - 0.0082 15.9 6.4 0.32 10.8 0.1 3.0 3 0 0 3 3 3 2 RING-like zinc finger zf-ANAPC11 PF12861.7 AMD18983.1 - 0.025 14.6 1.2 0.051 13.6 0.4 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 AMD18983.1 - 0.13 12.1 0.6 0.27 11.1 0.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 AMD18983.1 - 0.45 10.3 4.3 0.93 9.3 1.2 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 AMD18983.1 - 1.7 8.8 3.2 0.67 10.1 0.4 1.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 Asp PF00026.23 AMD18984.1 - 8.8e-73 245.5 0.1 1.1e-72 245.1 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD18984.1 - 3.6e-09 37.1 1.1 1.5e-08 35.1 1.1 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AMD18984.1 - 0.0019 18.8 0.1 5.8 7.6 0.0 3.5 3 0 0 3 3 3 1 Aspartyl protease TAXi_C PF14541.6 AMD18984.1 - 0.089 12.6 0.0 0.19 11.5 0.0 1.6 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Asp PF00026.23 AMD18985.1 - 1.8e-64 218.2 0.1 2.1e-64 217.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD18985.1 - 1.5e-12 48.1 0.0 2.3e-11 44.3 0.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 AMD18985.1 - 0.045 13.5 0.0 0.16 11.8 0.0 1.8 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 AMD18985.1 - 0.22 12.2 0.6 1.8 9.2 0.1 2.6 2 1 0 2 2 2 0 Aspartyl protease RNA_polI_A14 PF08203.11 AMD18986.1 - 6.1e-21 74.9 5.1 6.8e-21 74.8 0.0 2.2 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 Semialdhyde_dhC PF02774.18 AMD18987.1 - 4.3e-43 147.5 0.0 5.9e-43 147.1 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 AMD18987.1 - 1.1e-31 109.8 0.0 1.9e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 AMD18987.1 - 0.027 14.7 0.0 0.053 13.8 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DXP_reductoisom PF02670.16 AMD18987.1 - 0.13 12.9 0.0 0.34 11.6 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Methyltransf_16 PF10294.9 AMD18988.1 - 1.4e-06 28.1 0.9 0.0012 18.6 0.0 2.4 2 0 0 2 2 2 2 Lysine methyltransferase SAC3_GANP PF03399.16 AMD18989.1 - 1.2e-99 333.4 0.7 1.9e-99 332.8 0.7 1.3 1 0 0 1 1 1 1 SAC3/GANP family SAC3 PF12209.8 AMD18989.1 - 2.3e-17 62.9 1.4 2.3e-17 62.9 1.4 2.3 2 0 0 2 2 2 1 Leucine permease transcriptional regulator helical domain Na_H_Exchanger PF00999.21 AMD18990.1 - 4.6e-86 289.0 23.8 5.6e-86 288.7 23.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.10 AMD18990.1 - 2.7e-62 211.5 48.2 1.2e-59 202.8 48.2 2.0 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus CRM1_repeat_2 PF18784.1 AMD18990.1 - 0.11 12.2 0.1 0.63 9.7 0.0 2.1 2 0 0 2 2 2 0 CRM1 / Exportin repeat 2 TPR_11 PF13414.6 AMD18991.1 - 1.4e-07 31.0 1.7 0.018 14.7 0.5 4.4 4 0 0 4 4 4 2 TPR repeat TPR_2 PF07719.17 AMD18991.1 - 4.8e-07 29.4 3.2 0.35 11.1 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD18991.1 - 1e-05 25.6 3.5 0.12 12.7 0.1 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AMD18991.1 - 1.1e-05 25.2 9.4 0.42 10.9 0.2 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 AMD18991.1 - 1.7e-05 25.2 7.5 0.44 11.1 0.1 4.4 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 AMD18991.1 - 4.1e-05 23.3 1.0 12 6.2 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 AMD18991.1 - 0.00029 21.4 0.2 8.1 7.6 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 AMD18991.1 - 0.0014 18.1 0.1 1 8.6 0.0 2.3 2 0 0 2 2 2 2 MalT-like TPR region TPR_1 PF00515.28 AMD18991.1 - 0.013 15.3 10.7 7.7 6.5 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_15 PF13429.6 AMD18991.1 - 0.02 14.1 0.5 8.2 5.5 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 AMD18991.1 - 0.026 14.9 1.1 10 6.8 0.4 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 AMD18991.1 - 0.028 15.0 0.2 6.1 7.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat SH3_9 PF14604.6 AMD18992.1 - 1.7e-12 47.0 0.1 4.1e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AMD18992.1 - 4.2e-12 45.5 0.0 1.1e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AMD18992.1 - 2.6e-07 30.2 0.0 5.6e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Cwf_Cwc_15 PF04889.12 AMD18993.1 - 2.7e-16 60.1 27.9 1.4e-06 28.2 20.9 3.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.13 AMD18993.1 - 0.02 14.8 6.0 0.024 14.5 6.0 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region SLS PF14611.6 AMD18994.1 - 8.7e-40 136.9 6.5 1.4e-39 136.3 6.5 1.3 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Fur_reg_FbpB PF13040.6 AMD18994.1 - 0.09 12.3 0.1 0.4 10.3 0.1 2.1 1 0 0 1 1 1 0 Fur-regulated basic protein B Pro_dh PF01619.18 AMD18996.1 - 7.6e-61 206.2 0.0 9.6e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase Diphthami_syn_2 PF01902.17 AMD18997.1 - 2.2e-35 122.1 0.0 1.1e-34 119.8 0.0 2.1 2 1 0 2 2 2 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 AMD18997.1 - 3.8e-14 52.7 0.0 7.6e-10 38.9 0.0 2.6 2 1 0 2 2 2 2 Endoribonuclease L-PSP DUF3196 PF11428.8 AMD18997.1 - 0.06 12.9 0.5 0.1 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3196) Neprosin_AP PF14365.6 AMD18998.1 - 0.28 11.7 6.4 0.072 13.6 1.5 2.5 2 1 0 2 2 2 0 Neprosin activation peptide Sec1 PF00995.23 AMD18999.1 - 9.2e-84 282.7 2.8 1.1e-83 282.5 2.8 1.0 1 0 0 1 1 1 1 Sec1 family Glyco_hydro81C PF17652.1 AMD19000.1 - 2.3e-155 517.2 3.2 3.1e-155 516.7 3.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 AMD19000.1 - 6.4e-91 304.9 0.5 8.9e-91 304.4 0.2 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 N-terminal domain DUF4477 PF14780.6 AMD19001.1 - 0.0043 16.7 3.1 0.044 13.4 0.3 2.4 1 1 0 2 2 2 2 Domain of unknown function (DUF4477) WD40 PF00400.32 AMD19002.1 - 0.0065 17.3 1.8 61 4.7 0.0 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Lactonase PF10282.9 AMD19002.1 - 0.012 14.9 0.1 4 6.6 0.0 2.6 2 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Sec5 PF15469.6 AMD19004.1 - 3.7e-51 173.6 4.9 3.7e-51 173.6 4.9 2.1 2 0 0 2 2 2 1 Exocyst complex component Sec5 MRP-L46 PF11788.8 AMD19004.1 - 0.075 13.8 0.0 0.22 12.3 0.0 1.8 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 Jnk-SapK_ap_N PF09744.9 AMD19004.1 - 1 9.6 5.5 29 4.9 0.0 3.5 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 LSM PF01423.22 AMD19005.1 - 5.8e-17 61.1 0.1 6.8e-17 60.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain Tail_tube PF10618.9 AMD19005.1 - 0.0044 16.9 0.0 0.18 11.7 0.0 2.0 1 1 1 2 2 2 1 Phage tail tube protein SM-ATX PF14438.6 AMD19005.1 - 0.013 15.6 0.1 0.021 15.0 0.1 1.3 1 1 0 1 1 1 0 Ataxin 2 SM domain PTPS PF01242.19 AMD19005.1 - 0.071 13.1 0.2 0.09 12.7 0.2 1.1 1 0 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase Pep3_Vps18 PF05131.14 AMD19006.1 - 8.1e-35 119.8 0.1 5.2e-34 117.2 0.0 2.3 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 AMD19006.1 - 3.4e-08 33.5 0.8 3.4e-08 33.5 0.8 2.8 2 1 0 2 2 2 1 Region in Clathrin and VPS zf-RING_UBOX PF13445.6 AMD19006.1 - 1.5e-05 25.0 1.8 3.7e-05 23.6 1.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AMD19006.1 - 0.00012 21.8 2.3 0.00042 20.1 2.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AMD19006.1 - 0.00057 20.2 2.8 0.00057 20.2 2.8 2.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 AMD19006.1 - 0.00071 19.4 3.4 0.0028 17.5 3.4 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 AMD19006.1 - 0.0029 18.0 0.8 0.02 15.3 0.6 2.6 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Spo0A_C PF08769.11 AMD19006.1 - 0.0063 16.6 0.5 0.052 13.6 0.1 2.4 2 0 0 2 2 2 1 Sporulation initiation factor Spo0A C terminal DUF2294 PF10057.9 AMD19006.1 - 0.014 15.6 0.7 0.052 13.7 0.7 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) zf-RING_11 PF17123.5 AMD19006.1 - 0.016 15.0 7.2 0.049 13.4 7.2 1.9 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 AMD19006.1 - 0.036 13.7 0.5 0.036 13.7 0.5 2.3 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 AMD19006.1 - 0.065 13.3 1.9 0.16 12.0 1.9 1.7 1 0 0 1 1 1 0 Zinc-finger zf-RING_5 PF14634.6 AMD19006.1 - 0.37 10.8 14.5 0.14 12.1 10.0 2.5 2 1 0 2 2 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 AMD19006.1 - 0.63 10.4 4.5 2.5 8.5 4.5 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain TFIID_30kDa PF03540.13 AMD19007.1 - 9.1e-26 89.6 0.1 1.5e-25 88.8 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit CBFD_NFYB_HMF PF00808.23 AMD19007.1 - 0.092 13.0 0.1 1.2 9.4 0.0 2.5 2 1 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CDC37_N PF03234.14 AMD19008.1 - 3.3e-43 147.7 4.9 3.3e-43 147.7 4.9 3.7 4 1 1 5 5 5 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 AMD19008.1 - 1.7e-39 134.4 5.2 1.7e-39 134.4 5.2 2.1 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 AMD19008.1 - 9.5e-31 105.9 8.7 9.5e-31 105.9 8.7 3.3 4 0 0 4 4 4 1 Cdc37 C terminal domain HCMV_UL139 PF12507.8 AMD19008.1 - 0.024 15.0 1.6 0.058 13.8 0.2 2.2 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein GvpG PF05120.12 AMD19008.1 - 8.9 6.4 10.6 3.2 7.8 0.1 3.6 3 0 0 3 3 3 0 Gas vesicle protein G DUF2415 PF10313.9 AMD19009.1 - 1.5e-20 72.9 1.5 3e-20 71.9 1.5 1.6 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) Stb3 PF10330.9 AMD19010.1 - 3e-31 107.3 0.1 3e-31 107.3 0.1 1.9 2 0 0 2 2 2 1 Putative Sin3 binding protein TFIIA PF03153.13 AMD19010.1 - 7.2e-07 29.6 33.5 2e-05 24.8 28.5 2.4 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 AMD19010.1 - 0.4 10.6 22.7 0.023 14.7 15.8 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF3533 PF12051.8 AMD19010.1 - 1.4 7.8 6.6 2.4 7.0 6.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) TERB2 PF15101.6 AMD19010.1 - 2.3 8.3 17.3 0.94 9.5 14.0 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 V_ATPase_I PF01496.19 AMD19010.1 - 6.4 4.6 11.4 11 3.7 11.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YfhO PF09586.10 AMD19010.1 - 8.2 4.5 7.7 11 4.1 7.7 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Activator_LAG-3 PF11498.8 AMD19010.1 - 9.8 5.0 41.1 20 4.0 41.1 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Stm1_N PF09598.10 AMD19011.1 - 1.1e-09 39.0 5.6 1.1e-09 39.0 5.6 3.4 1 1 1 2 2 2 1 Stm1 HABP4_PAI-RBP1 PF04774.15 AMD19011.1 - 0.0049 17.7 6.4 0.0049 17.7 6.4 2.7 1 1 1 2 2 2 1 Hyaluronan / mRNA binding family CENP-U PF13097.6 AMD19011.1 - 8.8 6.2 16.7 2.3 8.2 1.5 2.2 2 0 0 2 2 2 0 CENP-A nucleosome associated complex (NAC) subunit NUDIX PF00293.28 AMD19012.1 - 1.3e-13 51.1 0.0 3.2e-13 49.8 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain DUF1075 PF06388.11 AMD19012.1 - 0.031 14.3 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) AMP-binding PF00501.28 AMD19013.1 - 3.1e-83 279.7 0.0 3.9e-83 279.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AMD19013.1 - 3.5e-25 88.8 0.2 7.6e-25 87.7 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AMD19013.1 - 3.4e-19 68.5 0.2 6.8e-19 67.5 0.2 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Sec7 PF01369.20 AMD19014.1 - 1.1e-66 224.0 0.1 4.2e-66 222.1 0.1 2.1 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 AMD19014.1 - 1.9e-41 141.6 2.1 1.9e-41 141.6 2.1 5.2 5 1 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 AMD19014.1 - 1.3e-28 98.6 0.8 1.3e-28 98.6 0.8 5.2 6 1 0 6 6 6 1 Domain of unknown function (DUF1981) DCB PF16213.5 AMD19014.1 - 2.4e-14 53.4 18.3 5.4e-13 49.0 2.5 5.1 5 1 0 5 5 5 2 Dimerisation and cyclophilin-binding domain of Mon2 GTP_EFTU PF00009.27 AMD19015.1 - 6.7e-46 156.3 0.0 1.7e-45 155.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AMD19015.1 - 1.4e-33 115.6 0.5 3.7e-33 114.2 0.5 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AMD19015.1 - 2.9e-06 27.6 2.6 3.6e-06 27.3 0.7 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AMD19015.1 - 0.0031 17.6 0.6 0.023 14.8 0.1 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase IPK PF03770.16 AMD19016.1 - 4.7e-50 170.2 0.1 6e-50 169.9 0.1 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase Zip PF02535.22 AMD19017.1 - 1.5e-70 238.1 8.6 1.5e-70 238.1 8.6 1.7 2 0 0 2 2 2 1 ZIP Zinc transporter HupE_UreJ PF04955.12 AMD19017.1 - 0.001 18.6 3.3 0.001 18.6 3.3 1.8 2 0 0 2 2 2 1 HupE / UreJ protein HMG_box PF00505.19 AMD19018.1 - 8.3e-12 45.4 3.1 8.3e-12 45.4 3.1 2.5 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AMD19018.1 - 7.8e-08 32.8 2.5 7.8e-08 32.8 2.5 2.4 2 1 0 2 2 2 1 HMG-box domain Transketolase_N PF00456.21 AMD19018.1 - 0.036 13.0 0.5 0.054 12.4 0.5 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain DUF3086 PF11285.8 AMD19018.1 - 6.3 5.8 9.3 0.045 12.9 0.3 1.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3086) MRP-S28 PF10213.9 AMD19019.1 - 9.8e-51 171.5 4.4 2.1e-50 170.4 4.4 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein PRK PF00485.18 AMD19019.1 - 0.89 9.3 4.1 0.74 9.5 0.6 2.4 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family Ada3 PF10198.9 AMD19020.1 - 4.2e-44 149.9 4.3 4.2e-44 149.9 4.3 2.1 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 Fib_alpha PF08702.10 AMD19020.1 - 2 8.6 8.6 1.5 9.0 1.7 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4404 PF14357.6 AMD19020.1 - 3 8.6 7.7 3.3 8.4 1.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF572 PF04502.13 AMD19020.1 - 3 7.4 23.9 0.6 9.7 8.8 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) Peptidase_M16 PF00675.20 AMD19021.1 - 2.4e-52 176.9 0.0 1e-51 174.8 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AMD19021.1 - 1e-36 126.7 0.0 3.7e-36 124.9 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain CybS PF05328.12 AMD19022.1 - 4.5e-48 162.3 0.0 5.4e-48 162.1 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit PXA PF02194.15 AMD19024.1 - 4.4e-11 43.1 3.3 8e-11 42.2 1.6 2.3 2 1 0 2 2 2 1 PXA domain Nexin_C PF08628.12 AMD19024.1 - 0.034 14.7 0.1 0.19 12.3 0.0 2.2 2 0 0 2 2 2 0 Sorting nexin C terminal PseudoU_synth_2 PF00849.22 AMD19025.1 - 1.9e-18 67.1 0.3 2.1e-13 50.6 0.0 2.2 1 1 1 2 2 2 2 RNA pseudouridylate synthase Nipped-B_C PF12830.7 AMD19026.1 - 1.3e-32 113.3 0.4 1.3e-32 113.3 0.4 2.9 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 AMD19026.1 - 8.8e-15 54.7 3.7 3.5e-14 52.8 1.0 3.1 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Opacity PF02462.15 AMD19026.1 - 0.066 13.3 0.0 0.2 11.8 0.0 1.8 2 0 0 2 2 2 0 Opacity family porin protein HEAT PF02985.22 AMD19026.1 - 0.64 10.4 3.5 19 5.9 0.0 4.4 5 0 0 5 5 5 0 HEAT repeat SAS4 PF15460.6 AMD19027.1 - 2.8e-24 85.1 5.6 2.8e-24 85.1 5.6 2.2 2 1 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 RICTOR_phospho PF14665.6 AMD19027.1 - 0.4 11.0 4.9 1.3 9.4 4.9 1.8 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, phosphorylation-site Metallophos PF00149.28 AMD19028.1 - 4.4e-12 46.9 1.0 7.1e-12 46.3 1.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Sec10 PF07393.11 AMD19029.1 - 5.7e-181 603.5 23.5 7.2e-181 603.2 23.5 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 Phosducin PF02114.16 AMD19030.1 - 7.3e-05 21.8 0.0 8.7e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 AMD19030.1 - 0.0022 18.0 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin ubiquitin PF00240.23 AMD19031.1 - 1.2e-34 117.9 0.5 2.9e-34 116.6 0.5 1.7 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 AMD19031.1 - 1.3e-22 79.7 1.3 1.3e-22 79.7 1.3 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 AMD19031.1 - 6.8e-16 57.9 0.6 6.8e-16 57.9 0.6 2.1 2 1 1 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AMD19031.1 - 2.4e-05 24.7 0.3 0.00013 22.4 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AMD19031.1 - 0.00098 19.2 0.5 0.0025 17.9 0.5 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 AMD19031.1 - 0.0049 17.2 0.6 0.011 16.0 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 AMD19031.1 - 0.0063 16.4 0.0 0.0096 15.8 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 AMD19031.1 - 0.013 16.1 0.4 0.019 15.5 0.4 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 AMD19031.1 - 0.018 15.1 1.1 5.3 7.2 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain PRELI PF04707.14 AMD19033.1 - 3.4e-54 182.9 0.4 4.7e-54 182.5 0.4 1.1 1 0 0 1 1 1 1 PRELI-like family DHHC PF01529.20 AMD19034.1 - 6.1e-29 100.8 18.6 6.1e-29 100.8 18.6 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase dCMP_cyt_deam_1 PF00383.23 AMD19036.1 - 5.9e-16 58.2 0.2 7.5e-16 57.9 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 AMD19036.1 - 7.6e-08 32.6 0.1 1.2e-07 31.9 0.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Peptidase_M24 PF00557.24 AMD19037.1 - 8e-53 179.2 0.1 1e-52 178.9 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 AMD19037.1 - 9.5e-17 61.0 7.6 9.5e-17 61.0 7.6 1.8 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding ATP-cone PF03477.16 AMD19037.1 - 0.016 15.7 0.2 0.8 10.3 0.1 2.3 2 0 0 2 2 2 0 ATP cone domain RGM_N PF06535.12 AMD19037.1 - 0.018 15.3 0.2 0.033 14.4 0.2 1.4 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) N-terminus DUF3222 PF11519.8 AMD19037.1 - 0.065 13.5 0.6 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3222) Pkinase PF00069.25 AMD19038.1 - 5.1e-64 216.2 0.0 7.6e-64 215.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19038.1 - 1.2e-36 126.4 0.0 1.8e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19038.1 - 2.1e-08 33.9 0.0 6.6e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 AMD19038.1 - 8.9e-06 24.9 4.6 0.00025 20.1 0.0 3.0 3 1 0 3 3 3 2 Haspin like kinase domain Kdo PF06293.14 AMD19038.1 - 0.022 14.1 0.0 0.098 12.0 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD19038.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SGT1 PF07093.11 AMD19039.1 - 4.7e-09 35.3 6.6 8.7e-09 34.4 0.0 2.2 2 0 0 2 2 2 1 SGT1 protein DUF3090 PF11290.8 AMD19039.1 - 0.16 11.8 1.8 0.39 10.5 1.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) Stress-antifung PF01657.17 AMD19039.1 - 1.5 9.5 3.5 18 6.0 0.5 2.8 2 1 1 3 3 3 0 Salt stress response/antifungal APG5 PF04106.12 AMD19040.1 - 2.7e-43 148.2 0.0 3.3e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 ACAS_N PF16177.5 AMD19040.1 - 0.6 10.1 5.0 23 5.0 0.0 3.4 3 0 0 3 3 3 0 Acetyl-coenzyme A synthetase N-terminus Methyltransf_12 PF08242.12 AMD19041.1 - 3e-16 59.9 0.1 3.3e-15 56.6 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD19041.1 - 4.7e-16 59.1 0.2 1.1e-15 57.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD19041.1 - 2.1e-12 47.6 0.0 4.9e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD19041.1 - 1.7e-09 38.2 0.0 4e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD19041.1 - 1.4e-07 31.4 0.0 2.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Nucleo_P87 PF07267.11 AMD19041.1 - 0.018 14.0 9.8 0.027 13.4 9.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NNMT_PNMT_TEMT PF01234.17 AMD19041.1 - 0.082 12.1 0.0 6.6 5.8 0.0 2.2 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 AMD19041.1 - 0.15 13.1 0.0 0.32 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain GAGA_bind PF06217.12 AMD19041.1 - 0.18 12.0 5.5 0.31 11.3 5.5 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family SLC12 PF03522.15 AMD19041.1 - 4.9 6.1 8.1 8 5.4 8.1 1.5 1 0 0 1 1 1 0 Solute carrier family 12 Mitofilin PF09731.9 AMD19041.1 - 6.4 5.5 19.8 8.4 5.1 19.8 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Hamartin PF04388.12 AMD19041.1 - 7 5.2 16.7 9.4 4.8 16.7 1.2 1 0 0 1 1 1 0 Hamartin protein Macoilin PF09726.9 AMD19041.1 - 7 5.1 13.7 10 4.5 13.7 1.3 1 0 0 1 1 1 0 Macoilin family ACPS PF01648.20 AMD19042.1 - 1.2e-13 51.1 0.0 1.7e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily ABC_membrane_2 PF06472.15 AMD19043.1 - 2.7e-82 276.2 9.9 2.7e-82 276.2 9.9 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 AMD19043.1 - 1.1e-13 51.9 0.0 2.7e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AMD19043.1 - 0.0072 15.8 0.1 0.39 10.1 0.0 2.2 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Nop53 PF07767.11 AMD19045.1 - 6.3e-94 315.6 43.3 7.3e-94 315.4 43.3 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) ResB PF05140.14 AMD19045.1 - 0.19 10.4 0.7 0.25 10.0 0.7 1.2 1 0 0 1 1 1 0 ResB-like family Oxysterol_BP PF01237.18 AMD19046.1 - 1.3e-58 198.7 3.0 6.1e-56 189.9 3.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein DHFR_1 PF00186.19 AMD19047.1 - 3.5e-28 98.3 0.0 4.5e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase PAC4 PF16093.5 AMD19048.1 - 0.00013 22.1 0.0 0.00019 21.5 0.0 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 CheX PF13690.6 AMD19048.1 - 0.019 15.2 0.0 0.033 14.4 0.0 1.4 1 1 0 1 1 1 0 Chemotaxis phosphatase CheX Pyr_redox_3 PF13738.6 AMD19049.1 - 5.5e-22 78.4 0.0 9.2e-20 71.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 AMD19049.1 - 6.1e-17 61.2 0.4 2e-11 43.1 0.1 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 AMD19049.1 - 5e-13 48.9 0.0 3.1e-11 43.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 AMD19049.1 - 4.3e-09 36.0 0.1 3.2e-06 26.5 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 AMD19049.1 - 1.5e-05 24.4 0.0 0.0001 21.7 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 AMD19049.1 - 0.00014 22.1 0.0 0.001 19.3 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 AMD19049.1 - 0.0016 17.9 0.0 0.0049 16.3 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 AMD19049.1 - 0.0018 18.8 0.4 0.56 10.8 0.1 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AMD19049.1 - 0.0028 16.8 0.1 0.0053 15.9 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 AMD19049.1 - 0.0055 17.1 0.0 5.6 7.5 0.0 2.7 2 1 0 2 2 2 2 Putative NAD(P)-binding Lycopene_cycl PF05834.12 AMD19049.1 - 0.039 13.0 0.0 0.065 12.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 AMD19049.1 - 0.063 12.9 0.1 1.3 8.5 0.0 2.7 3 0 0 3 3 3 0 FAD dependent oxidoreductase TrkA_N PF02254.18 AMD19049.1 - 0.14 12.4 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Ribosomal_L35Ae PF01247.18 AMD19050.1 - 1e-42 144.2 0.7 1.2e-42 144.0 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 AMD19050.1 - 8e-05 22.8 0.0 0.12 12.6 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Pkinase PF00069.25 AMD19051.1 - 5.8e-64 216.0 0.0 8.9e-64 215.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19051.1 - 6.4e-39 133.8 0.0 1e-38 133.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19051.1 - 5.3e-09 35.8 0.0 8.6e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD19051.1 - 0.02 14.8 0.5 0.046 13.6 0.6 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 AMD19051.1 - 0.039 13.3 1.4 0.12 11.7 1.4 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GrpE PF01025.19 AMD19052.1 - 3e-50 170.1 9.2 3.8e-50 169.8 9.2 1.1 1 0 0 1 1 1 1 GrpE DUF4349 PF14257.6 AMD19052.1 - 0.0026 17.2 2.7 0.0036 16.8 2.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) Uds1 PF15456.6 AMD19052.1 - 0.0064 16.6 3.8 0.012 15.8 3.8 1.4 1 0 0 1 1 1 1 Up-regulated During Septation TACC_C PF05010.14 AMD19052.1 - 0.054 13.3 15.1 0.4 10.4 0.6 2.1 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ATG16 PF08614.11 AMD19052.1 - 0.76 10.0 13.8 0.78 9.9 13.0 1.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF848 PF05852.11 AMD19052.1 - 1.9 8.6 11.4 17 5.5 8.3 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) OmpH PF03938.14 AMD19052.1 - 4 7.8 19.0 1 9.7 15.2 1.8 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Pkinase PF00069.25 AMD19053.1 - 3.3e-72 243.0 0.0 4.5e-72 242.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19053.1 - 3.7e-36 124.7 0.0 6.9e-36 123.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19053.1 - 1.2e-05 24.8 0.0 2.5e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AMD19053.1 - 6.5e-05 21.9 0.0 0.00011 21.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 AMD19053.1 - 0.00043 20.0 0.2 0.52 9.9 0.0 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 AMD19053.1 - 0.017 14.5 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 AMD19053.1 - 0.025 13.6 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 AMD19053.1 - 0.037 14.0 0.0 0.084 12.8 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Mss4 PF04421.13 AMD19054.1 - 0.042 14.0 0.3 15 5.8 0.0 2.4 2 0 0 2 2 2 0 Mss4 protein WD40 PF00400.32 AMD19054.1 - 0.11 13.4 7.5 1.1 10.3 0.0 4.3 6 0 0 6 6 6 0 WD domain, G-beta repeat PHD PF00628.29 AMD19055.1 - 5.6e-10 38.9 5.4 5.6e-10 38.9 5.4 2.1 2 0 0 2 2 2 1 PHD-finger YkyA PF10368.9 AMD19055.1 - 0.00068 19.4 1.4 0.00098 18.8 0.1 1.9 1 1 0 1 1 1 1 Putative cell-wall binding lipoprotein zf-ZPR1 PF03367.13 AMD19055.1 - 0.0063 16.4 0.6 0.014 15.3 0.1 1.9 1 1 1 2 2 2 1 ZPR1 zinc-finger domain WD40_alt PF14077.6 AMD19055.1 - 6.4 6.7 6.3 6.1 6.8 0.0 3.0 3 1 1 4 4 4 0 Alternative WD40 repeat motif DUF1691 PF07950.11 AMD19056.1 - 1.9e-19 70.3 6.0 1.6e-11 44.9 0.1 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1691) Gag_p12 PF01141.18 AMD19057.1 - 0.033 14.5 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 Gag polyprotein, inner coat protein p12 DUF4112 PF13430.6 AMD19058.1 - 1.8e-31 108.5 1.4 2.4e-31 108.1 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) PrgI PF12666.7 AMD19058.1 - 0.052 14.3 0.1 0.12 13.1 0.1 1.7 1 0 0 1 1 1 0 PrgI family protein AAA PF00004.29 AMD19059.1 - 1.7e-40 138.5 0.0 2.8e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD19059.1 - 7.4e-11 41.7 0.2 1.5e-10 40.7 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 AMD19059.1 - 7.7e-09 35.4 0.0 1.5e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AMD19059.1 - 8.2e-06 26.0 0.0 2e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 AMD19059.1 - 1.5e-05 24.3 0.0 2.5e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 AMD19059.1 - 2e-05 24.9 0.2 0.017 15.4 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 AMD19059.1 - 7.3e-05 22.8 0.3 0.00038 20.5 0.0 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AMD19059.1 - 0.00013 22.4 0.3 0.0022 18.4 0.0 2.4 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.12 AMD19059.1 - 0.00082 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AMD19059.1 - 0.0031 17.8 0.0 0.0077 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD19059.1 - 0.0087 16.6 0.4 0.028 15.0 0.0 2.1 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 AMD19059.1 - 0.011 15.8 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AMD19059.1 - 0.015 15.4 0.0 0.031 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 AMD19059.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 AMD19059.1 - 0.017 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 AMD19059.1 - 0.025 13.8 0.1 0.053 12.7 0.1 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain NTPase_1 PF03266.15 AMD19059.1 - 0.026 14.4 0.4 0.26 11.2 0.0 2.5 3 0 0 3 3 3 0 NTPase RNA_helicase PF00910.22 AMD19059.1 - 0.031 14.7 0.0 0.1 13.0 0.0 2.0 2 0 0 2 2 1 0 RNA helicase ATPase PF06745.13 AMD19059.1 - 0.035 13.4 0.1 0.49 9.7 0.1 2.3 1 1 0 2 2 2 0 KaiC AAA_25 PF13481.6 AMD19059.1 - 0.056 13.0 1.4 0.46 10.0 0.4 2.4 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 AMD19059.1 - 0.057 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 AMD19059.1 - 0.093 12.0 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 AMD19059.1 - 0.098 12.6 0.1 0.59 10.0 0.1 2.1 1 1 1 2 2 2 0 NACHT domain AAA_24 PF13479.6 AMD19059.1 - 0.13 11.9 1.0 0.27 10.9 0.3 2.0 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AMD19059.1 - 0.16 11.5 0.1 0.5 9.9 0.1 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region HLH PF00010.26 AMD19060.1 - 5.2e-15 55.1 0.0 9.8e-15 54.3 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ku_C PF03730.14 AMD19060.1 - 0.074 13.8 3.3 0.44 11.3 0.2 2.5 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm DUF592 PF04574.13 AMD19061.1 - 6e-65 217.7 0.4 1.5e-64 216.4 0.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF592) SIR2 PF02146.17 AMD19061.1 - 8.7e-64 214.7 0.0 1.5e-63 213.9 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 AMD19061.1 - 0.00075 19.2 0.1 0.052 13.3 0.0 2.7 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain SF3A2 PF16835.5 AMD19062.1 - 2.1e-22 79.3 0.0 3.9e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 AMD19062.1 - 1.3e-06 28.5 1.3 2.5e-06 27.7 1.3 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type OrsD PF12013.8 AMD19062.1 - 0.0046 17.4 0.1 0.0085 16.5 0.1 1.4 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_2 PF12756.7 AMD19062.1 - 0.036 14.4 0.1 0.059 13.7 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Nuf2 PF03800.14 AMD19063.1 - 3e-42 144.0 0.1 3e-42 144.0 0.1 2.7 2 1 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 AMD19063.1 - 2.6e-05 24.3 17.8 2.6e-05 24.3 17.8 3.5 3 1 1 4 4 4 1 Designed helical repeat protein 10 domain CENP-F_leu_zip PF10473.9 AMD19063.1 - 0.0085 16.1 25.0 0.0085 16.1 25.0 3.1 1 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 AMD19063.1 - 0.26 10.1 43.8 0.012 14.5 12.9 2.6 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF2935 PF11155.8 AMD19063.1 - 2.8 8.3 12.1 0.62 10.4 2.8 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) SlyX PF04102.12 AMD19063.1 - 4 8.1 29.6 0.34 11.6 5.4 4.9 4 1 2 6 6 6 0 SlyX PI_PP_I PF18363.1 AMD19063.1 - 6.7 7.0 11.8 0.96 9.7 0.2 3.0 2 1 1 3 3 3 0 Phosphoinositide phosphatase insertion domain CorA PF01544.18 AMD19065.1 - 0.032 13.5 0.6 0.081 12.2 0.6 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein IFRD PF05004.13 AMD19065.1 - 0.04 13.0 1.0 0.3 10.1 0.0 2.1 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) KIAA1430 PF13879.6 AMD19065.1 - 0.055 14.2 4.0 1.5 9.6 0.2 2.8 3 0 0 3 3 3 0 KIAA1430 homologue RecG_N PF17190.4 AMD19065.1 - 3.4 8.5 9.3 1.3 9.8 1.1 3.3 3 1 0 3 3 3 0 RecG N-terminal helical domain PAPS_reduct PF01507.19 AMD19066.1 - 3.4e-28 98.8 0.0 4.9e-27 95.1 0.0 2.1 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family CHCH PF06747.13 AMD19067.1 - 1.7e-06 28.0 0.4 2.3e-06 27.6 0.4 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 AMD19067.1 - 0.0027 17.7 0.6 0.0038 17.2 0.6 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 AMD19067.1 - 0.12 12.4 1.5 0.18 11.8 1.5 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Mannitol_dh_C PF08125.13 AMD19067.1 - 0.16 11.4 0.0 0.18 11.3 0.0 1.0 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain Sdh5 PF03937.16 AMD19068.1 - 9.5e-27 92.8 0.3 1.6e-26 92.1 0.3 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Spo7_2_N PF15407.6 AMD19068.1 - 0.12 12.0 0.4 4 7.1 0.0 2.6 2 0 0 2 2 2 0 Sporulation protein family 7 E1_DerP2_DerF2 PF02221.15 AMD19069.1 - 5.6e-26 91.6 0.0 6.6e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 ML domain Metallophos PF00149.28 AMD19070.1 - 9.6e-39 134.0 0.1 1.3e-38 133.6 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 AMD19070.1 - 0.09 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain STPPase_N PF16891.5 AMD19070.1 - 0.098 13.1 0.4 0.21 12.1 0.4 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain PCI PF01399.27 AMD19071.1 - 1.2e-12 48.3 1.4 7.9e-12 45.6 0.1 2.8 2 1 1 3 3 3 1 PCI domain DUF2300 PF10062.9 AMD19071.1 - 0.19 11.8 0.0 0.36 10.9 0.0 1.4 1 0 0 1 1 1 0 Predicted secreted protein (DUF2300) Smg4_UPF3 PF03467.15 AMD19072.1 - 5.9e-26 91.5 16.1 5.9e-26 91.5 16.1 3.0 2 1 0 2 2 2 1 Smg-4/UPF3 family FTO_NTD PF12933.7 AMD19072.1 - 1 8.6 5.7 0.095 11.9 0.9 1.8 2 0 0 2 2 2 0 FTO catalytic domain CENP-Q PF13094.6 AMD19073.1 - 0.0096 16.1 8.0 0.015 15.6 8.0 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit OmpH PF03938.14 AMD19073.1 - 0.066 13.6 6.6 0.77 10.1 8.0 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Antimicrobial_7 PF08102.11 AMD19073.1 - 0.14 12.4 0.6 0.35 11.1 0.1 1.9 2 0 0 2 2 2 0 Scorpion antimicrobial peptide DivIVA PF05103.13 AMD19073.1 - 0.54 10.3 6.9 0.32 11.1 1.4 2.5 1 1 2 3 3 3 0 DivIVA protein DivIC PF04977.15 AMD19073.1 - 0.78 9.6 14.8 1.3 8.9 2.7 4.2 3 1 1 4 4 4 0 Septum formation initiator YabA PF06156.13 AMD19073.1 - 0.87 10.3 14.0 3 8.5 5.0 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Tup_N PF08581.10 AMD19073.1 - 3 8.2 11.5 1.2 9.5 6.1 2.7 2 1 0 2 2 2 0 Tup N-terminal ZapB PF06005.12 AMD19073.1 - 6.2 7.4 19.7 2.1 8.9 8.2 3.4 2 1 1 3 3 3 0 Cell division protein ZapB HALZ PF02183.18 AMD19073.1 - 6.4 7.1 15.3 0.42 10.9 5.0 3.7 2 1 1 3 3 3 0 Homeobox associated leucine zipper APG6_N PF17675.1 AMD19073.1 - 9.3 6.8 17.3 4.3 7.9 12.7 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region LSM PF01423.22 AMD19074.1 - 3.4e-22 77.9 0.4 9.1e-22 76.5 0.4 1.7 1 1 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AMD19074.1 - 0.0079 16.3 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain DeoRC PF00455.22 AMD19074.1 - 0.029 14.3 0.2 0.032 14.1 0.2 1.2 1 0 0 1 1 1 0 DeoR C terminal sensor domain PRP38 PF03371.15 AMD19075.1 - 3.7e-41 140.9 4.0 4.4e-41 140.6 4.0 1.0 1 0 0 1 1 1 1 PRP38 family Mitoc_mL59 PF18126.1 AMD19076.1 - 5.1e-30 104.4 0.7 9.1e-30 103.6 0.7 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Condensin2nSMC PF12422.8 AMD19077.1 - 0.0062 16.7 0.1 0.025 14.8 0.1 2.1 1 0 0 1 1 1 1 Condensin II non structural maintenance of chromosomes subunit DER1 PF04511.15 AMD19078.1 - 0.0024 17.8 10.4 0.0035 17.3 10.4 1.2 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 AMD19078.1 - 0.24 11.4 6.9 8.1 6.4 6.9 2.2 1 1 0 1 1 1 0 Rhomboid family Prefoldin PF02996.17 AMD19079.1 - 1.6e-30 105.4 2.8 2.2e-30 105.0 2.8 1.2 1 0 0 1 1 1 1 Prefoldin subunit Pox_A_type_inc PF04508.12 AMD19079.1 - 0.03 14.2 0.1 0.082 12.8 0.1 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat SNAD4 PF18750.1 AMD19079.1 - 0.033 14.3 0.2 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_C PF05240.14 AMD19079.1 - 0.049 13.6 0.1 7.6 6.6 0.0 2.5 2 0 0 2 2 2 0 APOBEC-like C-terminal domain DZR PF12773.7 AMD19080.1 - 0.12 12.4 0.9 0.3 11.2 0.4 2.0 2 0 0 2 2 2 0 Double zinc ribbon Nup54_57_C PF18570.1 AMD19080.1 - 0.38 10.4 1.8 0.51 10.0 0.2 2.0 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain CYSTM PF12734.7 AMD19081.1 - 2.8e-05 24.3 46.9 0.0034 17.7 33.7 3.9 2 1 0 2 2 2 1 Cysteine-rich TM module stress tolerance EamA PF00892.20 AMD19082.1 - 1.6e-13 51.0 26.1 5.3e-08 33.1 7.1 2.5 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 AMD19082.1 - 5.9e-11 42.3 18.9 2.1e-10 40.4 18.9 1.8 1 1 0 1 1 1 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 AMD19082.1 - 4.7e-09 35.8 1.1 4.7e-09 35.8 1.1 2.0 2 1 0 2 2 2 1 Nucleotide-sugar transporter UAA PF08449.11 AMD19082.1 - 1.1e-07 31.3 21.8 1.5e-07 30.9 21.8 1.3 1 1 0 1 1 1 1 UAA transporter family SLC35F PF06027.12 AMD19082.1 - 0.00016 21.3 6.5 0.00016 21.3 6.5 2.1 1 1 0 2 2 2 1 Solute carrier family 35 TMEM234 PF10639.9 AMD19082.1 - 0.00021 21.3 12.9 0.0013 18.7 1.7 3.0 3 0 0 3 3 3 2 Putative transmembrane family 234 PUNUT PF16913.5 AMD19082.1 - 0.02 14.1 21.1 0.032 13.5 21.1 1.3 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport MpPF26 PF07666.11 AMD19082.1 - 0.34 11.0 11.6 1.2 9.2 3.0 3.3 2 1 1 3 3 3 0 M penetrans paralogue family 26 zf-C3HC4_2 PF13923.6 AMD19083.1 - 0.0015 18.4 0.7 0.0031 17.3 0.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD19083.1 - 0.004 17.2 0.1 0.0092 16.0 0.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AMD19083.1 - 0.005 16.7 0.2 0.012 15.4 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD19083.1 - 0.019 14.9 0.5 0.019 14.9 0.5 1.7 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 AMD19083.1 - 0.031 14.1 0.2 0.077 12.9 0.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 AMD19083.1 - 0.053 13.4 0.3 0.053 13.4 0.3 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FERM_M PF00373.18 AMD19083.1 - 0.06 13.7 1.0 2.8 8.4 0.0 2.8 2 1 0 2 2 2 0 FERM central domain Fer2_3 PF13085.6 AMD19083.1 - 0.071 13.1 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-RING_2 PF13639.6 AMD19083.1 - 0.11 12.8 0.5 0.11 12.8 0.5 1.8 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_4 PF15227.6 AMD19083.1 - 0.8 9.9 4.9 0.25 11.6 0.5 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Fibrillarin PF01269.17 AMD19084.1 - 1.6e-106 354.5 0.0 1.9e-106 354.2 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 AMD19084.1 - 2.5e-06 27.4 0.0 4.3e-06 26.6 0.0 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 AMD19084.1 - 0.011 15.8 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 AMD19084.1 - 0.057 13.2 0.0 0.093 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 AMD19084.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Steroid_dh PF02544.16 AMD19085.1 - 1.6e-32 112.5 9.0 3.4e-32 111.5 9.0 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 AMD19085.1 - 0.0015 18.1 1.2 0.0015 18.1 1.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.13 AMD19085.1 - 0.014 15.8 1.7 0.2 12.0 0.6 2.5 2 0 0 2 2 2 0 Phospholipid methyltransferase ICMT PF04140.14 AMD19085.1 - 0.027 14.9 3.3 0.11 12.9 0.3 2.3 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF5345 PF17280.2 AMD19085.1 - 1.6 8.8 3.6 28 4.8 2.8 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5345) Pkinase PF00069.25 AMD19086.1 - 6.3e-38 130.7 0.0 9.3e-20 71.1 0.0 3.6 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19086.1 - 5.5e-13 48.8 0.0 1.3e-07 31.2 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 AMD19086.1 - 0.049 12.9 0.0 5.8 6.1 0.0 2.3 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 AMD19086.1 - 0.065 12.8 0.0 0.27 10.8 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AMD19086.1 - 0.071 11.9 0.0 0.14 10.9 0.0 1.4 1 1 0 1 1 1 0 Fungal protein kinase APH PF01636.23 AMD19086.1 - 0.15 12.0 0.0 0.39 10.6 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family EMP24_GP25L PF01105.24 AMD19087.1 - 3.4e-30 105.3 3.0 3.4e-30 105.3 3.0 1.4 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD HEAT PF02985.22 AMD19088.1 - 1.6e-16 58.9 0.7 0.00034 20.6 0.0 7.9 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 AMD19088.1 - 4.6e-15 55.7 0.1 1.1e-09 38.6 0.0 5.3 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 AMD19088.1 - 3.2e-08 33.8 0.0 0.0011 19.3 0.0 5.4 4 2 2 6 6 6 2 HEAT repeats Cnd1 PF12717.7 AMD19088.1 - 2.2e-07 31.1 9.4 0.0067 16.5 0.1 4.1 3 1 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AMD19088.1 - 6e-05 23.6 0.4 1.5 9.4 0.0 4.8 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 AMD19088.1 - 0.00021 20.9 3.8 0.25 10.9 0.1 4.0 3 0 0 3 3 3 2 CLASP N terminal U3snoRNP10 PF12397.8 AMD19088.1 - 0.032 14.6 3.1 22 5.5 0.0 4.4 4 1 1 5 5 5 0 U3 small nucleolar RNA-associated protein 10 IBN_N PF03810.19 AMD19088.1 - 0.58 10.1 2.1 5.5 7.0 0.0 3.6 4 1 0 4 4 4 0 Importin-beta N-terminal domain SH3_1 PF00018.28 AMD19089.1 - 2.2e-08 33.6 0.3 7.6e-08 31.8 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 AMD19089.1 - 0.0069 16.2 0.1 0.02 14.7 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SAICAR_synt PF01259.18 AMD19090.1 - 5e-102 340.8 0.1 5.8e-102 340.6 0.1 1.0 1 0 0 1 1 1 1 SAICAR synthetase UPF0086 PF01868.16 AMD19090.1 - 0.12 12.3 0.1 0.35 10.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function UPF0086 Pkinase PF00069.25 AMD19091.1 - 7.2e-58 196.0 0.1 1e-56 192.2 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19091.1 - 4.6e-35 121.1 0.0 8.6e-23 80.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD19091.1 - 3.1e-05 22.9 0.0 5.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 AMD19092.1 - 1.2e-71 241.2 0.2 2.7e-71 240.1 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19092.1 - 6e-51 173.2 0.1 1.1e-50 172.3 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19092.1 - 6.1e-07 29.0 0.2 1.9e-05 24.2 0.0 2.3 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AMD19092.1 - 0.00052 18.9 0.0 0.0018 17.1 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 AMD19092.1 - 0.018 14.7 0.5 0.074 12.7 0.1 2.1 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 AMD19092.1 - 0.024 14.0 0.0 0.048 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 AMD19092.1 - 0.068 12.7 0.5 0.16 11.4 0.5 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Oxysterol_BP PF01237.18 AMD19093.1 - 1.1e-133 445.8 0.1 1.9e-133 444.9 0.1 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.6 AMD19093.1 - 4.4e-11 42.8 0.0 0.00015 22.0 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) PH PF00169.29 AMD19093.1 - 7.8e-11 42.4 0.4 2e-10 41.1 0.4 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 AMD19093.1 - 6.4e-09 36.0 0.2 1.7e-08 34.6 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Ank_2 PF12796.7 AMD19093.1 - 1.3e-08 35.3 0.0 0.00038 21.0 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 AMD19093.1 - 2.6e-08 33.5 0.0 0.0046 17.4 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 AMD19093.1 - 5.2e-08 33.3 0.0 0.00021 21.8 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 AMD19093.1 - 1.6e-05 25.1 0.0 0.00064 20.0 0.1 3.0 2 0 0 2 2 2 1 Ankyrin repeat PH_11 PF15413.6 AMD19093.1 - 0.00013 22.3 2.8 0.0006 20.2 0.7 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain Peptidase_M41 PF01434.18 AMD19093.1 - 0.29 10.9 1.6 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Peptidase family M41 FapA PF03961.13 AMD19093.1 - 0.38 9.3 5.2 0.67 8.5 5.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Phos_pyr_kin PF08543.12 AMD19094.1 - 3.2e-73 246.1 0.1 4.1e-73 245.8 0.1 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 AMD19094.1 - 1.6e-28 100.0 0.8 2.2e-28 99.5 0.3 1.5 2 0 0 2 2 2 1 TENA/THI-4/PQQC family PfkB PF00294.24 AMD19094.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 AMD19094.1 - 0.023 14.1 1.8 3.5 6.9 0.1 2.7 2 1 0 3 3 3 0 Hydroxyethylthiazole kinase family zf-C2H2 PF00096.26 AMD19095.1 - 0.0012 19.1 3.2 0.03 14.8 0.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD19095.1 - 0.4 11.6 6.6 4 8.5 0.1 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger His_Phos_1 PF00300.22 AMD19096.1 - 2.3e-29 102.5 0.0 5.6e-15 55.5 0.0 3.0 1 1 2 3 3 3 3 Histidine phosphatase superfamily (branch 1) Arginosuc_synth PF00764.19 AMD19097.1 - 4.1e-161 536.6 0.0 4.7e-161 536.4 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 AMD19097.1 - 1.1e-05 25.1 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AMD19097.1 - 0.00081 18.3 0.1 0.0015 17.4 0.1 1.4 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.21 AMD19097.1 - 0.012 15.3 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase NAD_Gly3P_dh_N PF01210.23 AMD19098.1 - 1.2e-49 168.3 0.0 2.3e-49 167.4 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 AMD19098.1 - 4.9e-40 137.1 0.1 9.6e-40 136.1 0.1 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 AMD19098.1 - 0.013 16.1 0.0 9.1 6.9 0.0 3.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF21 PF01595.20 AMD19099.1 - 2.1e-35 122.0 0.0 3.9e-35 121.1 0.0 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 AMD19099.1 - 0.0002 21.7 0.0 0.26 11.8 0.0 2.7 2 0 0 2 2 2 2 CBS domain Pkinase PF00069.25 AMD19100.1 - 6.2e-48 163.5 0.0 1.3e-47 162.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19100.1 - 1.6e-23 83.4 0.1 3.1e-23 82.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19100.1 - 8.8e-05 22.0 0.0 0.00017 21.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD19100.1 - 0.0026 17.7 0.0 0.012 15.6 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 AMD19100.1 - 0.013 15.2 0.0 0.55 9.8 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pribosyl_synth PF14572.6 AMD19101.1 - 8.5e-42 143.3 0.2 1.5e-41 142.5 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AMD19101.1 - 4.1e-37 126.7 0.6 1e-36 125.4 0.0 2.0 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AMD19101.1 - 6e-12 45.4 0.3 3.2e-11 43.0 0.3 2.0 1 1 0 1 1 1 1 Phosphoribosyl transferase domain RE_BsaWI PF18643.1 AMD19101.1 - 0.035 14.0 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 BsaWI restriction endonuclease type 2 Actin PF00022.19 AMD19102.1 - 9.8e-109 363.6 0.0 3.1e-108 362.0 0.0 1.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AMD19102.1 - 0.0019 17.0 0.0 0.0083 15.0 0.0 1.9 1 1 0 1 1 1 1 MreB/Mbl protein Actin_micro PF17003.5 AMD19102.1 - 0.15 11.2 0.1 0.93 8.6 0.0 1.9 2 0 0 2 2 2 0 Putative actin-like family Pkinase PF00069.25 AMD19103.1 - 1.2e-49 169.0 0.1 3.6e-49 167.5 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19103.1 - 3.3e-21 75.7 0.1 1.1e-20 74.0 0.0 1.9 2 1 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 AMD19103.1 - 1.9e-05 24.4 0.0 0.051 13.2 0.0 2.7 2 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AMD19103.1 - 0.00012 22.1 0.0 0.3 11.0 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 AMD19103.1 - 0.0017 18.0 0.4 0.0041 16.7 0.4 1.6 1 0 0 1 1 1 1 RIO1 family LSDAT_euk PF18139.1 AMD19103.1 - 0.1 11.9 0.1 0.21 10.9 0.1 1.4 1 0 0 1 1 1 0 SLOG in TRPM ASF1_hist_chap PF04729.13 AMD19105.1 - 1.4e-70 236.2 0.0 2.1e-70 235.6 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone BUD22 PF09073.10 AMD19105.1 - 2.2 7.5 42.0 2.6 7.3 42.0 1.1 1 0 0 1 1 1 0 BUD22 PA26 PF04636.13 AMD19105.1 - 2.3 7.1 5.3 2.9 6.7 5.3 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Mg_trans_NIPA PF05653.14 AMD19106.1 - 1.1e-11 44.4 17.2 7.1e-06 25.3 0.8 2.1 1 1 1 2 2 2 2 Magnesium transporter NIPA Multi_Drug_Res PF00893.19 AMD19106.1 - 0.26 12.0 6.0 0.073 13.7 2.1 2.2 2 0 0 2 2 2 0 Small Multidrug Resistance protein DUF4083 PF13314.6 AMD19106.1 - 4.3 7.4 10.4 16 5.5 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) His_Phos_1 PF00300.22 AMD19107.1 - 9.3e-35 120.1 0.1 1.2e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lectin_leg-like PF03388.13 AMD19108.1 - 8.5e-15 54.7 0.0 1.1e-07 31.5 0.0 2.2 2 0 0 2 2 2 2 Legume-like lectin family DUF1402 PF07182.11 AMD19108.1 - 0.029 13.5 0.1 0.048 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) Pho86 PF11124.8 AMD19109.1 - 3.1e-100 335.4 1.0 3.5e-100 335.2 1.0 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 PET10 PF17316.2 AMD19111.1 - 6.1e-46 157.0 6.0 1.3e-44 152.6 6.0 2.0 1 1 0 1 1 1 1 Petite colonies protein 10 DUF3676 PF12429.8 AMD19111.1 - 0.014 15.3 1.0 0.014 15.3 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3676) NAP PF00956.18 AMD19112.1 - 7.3e-88 294.3 7.6 7.3e-88 294.3 7.6 1.8 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) BUD22 PF09073.10 AMD19112.1 - 2.4 7.4 22.4 3.1 7.0 14.9 2.1 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 AMD19112.1 - 3.1 5.9 26.6 1.9 6.6 18.1 2.2 2 0 0 2 2 2 0 Nop14-like family Ribul_P_3_epim PF00834.19 AMD19113.1 - 4e-68 228.7 0.0 5.3e-68 228.3 0.0 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.24 AMD19113.1 - 0.025 14.1 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family ThiG PF05690.14 AMD19113.1 - 0.027 13.8 0.1 0.065 12.5 0.0 1.6 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG CUE PF02845.16 AMD19113.1 - 0.076 12.7 2.6 0.083 12.6 0.3 2.0 2 0 0 2 2 2 0 CUE domain QRPTase_C PF01729.19 AMD19113.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Alb1 PF09135.11 AMD19114.1 - 1.3e-15 58.1 7.4 1.3e-15 58.1 7.4 1.6 2 0 0 2 2 2 1 Alb1 HSP70 PF00012.20 AMD19114.1 - 0.071 11.3 1.1 0.09 10.9 1.1 1.1 1 0 0 1 1 1 0 Hsp70 protein DUF5564 PF17719.1 AMD19114.1 - 0.15 12.2 0.5 0.15 12.2 0.5 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5564) RGI1 PF10843.8 AMD19114.1 - 0.19 11.4 0.0 0.19 11.4 0.0 1.4 2 0 0 2 2 2 0 Respiratory growth induced protein 1 DUF5427 PF10310.9 AMD19115.1 - 2.9e-102 343.1 19.1 3.3e-102 342.8 19.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) ATP-grasp_4 PF13535.6 AMD19115.1 - 0.04 13.5 0.6 2.6 7.6 0.0 2.9 2 1 1 3 3 3 0 ATP-grasp domain Tir_receptor_C PF07489.11 AMD19115.1 - 4.2 7.3 9.3 8.3 6.3 9.3 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF4407 PF14362.6 AMD19115.1 - 6.7 6.0 10.0 11 5.2 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1687 PF07955.11 AMD19116.1 - 1.3e-20 74.2 0.0 1.8e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) LSM PF01423.22 AMD19117.1 - 2.9e-14 52.5 0.2 4.6e-14 51.9 0.2 1.3 1 0 0 1 1 1 1 LSM domain Acyl-CoA_dh_1 PF00441.24 AMD19118.1 - 9.4e-19 68.1 0.2 1.5e-18 67.5 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 AMD19118.1 - 4.4e-11 42.8 0.2 2.9e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 AMD19118.1 - 0.0012 19.4 0.0 0.0027 18.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 AMD19118.1 - 0.012 15.9 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain DUF3316 PF11777.8 AMD19118.1 - 0.024 14.7 0.0 0.069 13.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) GCD14 PF08704.10 AMD19119.1 - 3.8e-78 262.6 0.3 7.1e-77 258.4 0.3 2.1 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 AMD19119.1 - 9e-05 22.2 0.0 0.00032 20.5 0.0 2.0 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term ABC_tran_Xtn PF12848.7 AMD19119.1 - 5.5 7.1 9.3 0.093 12.8 1.1 2.2 2 1 0 2 2 2 0 ABC transporter zf-H2C2 PF09337.10 AMD19120.1 - 2.9e-15 56.2 1.9 5.6e-15 55.3 1.9 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 AMD19120.1 - 5.1e-12 45.7 0.4 1.1e-11 44.7 0.4 1.5 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 AMD19120.1 - 0.00014 22.1 0.0 0.00073 19.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Helicase_RecD PF05127.14 AMD19120.1 - 0.013 15.3 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 Helicase Acetyltransf_3 PF13302.7 AMD19120.1 - 0.042 14.5 0.1 0.15 12.8 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF5310 PF17237.2 AMD19121.1 - 7.6e-22 76.9 2.6 9.2e-22 76.7 2.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5310) Pkinase PF00069.25 AMD19122.1 - 6.1e-60 202.8 0.0 1.1e-59 202.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19122.1 - 3.5e-37 128.1 0.0 6.1e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19122.1 - 0.00039 19.8 0.0 0.00069 19.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 AMD19122.1 - 0.0036 16.4 0.0 0.0061 15.7 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 PG_binding_1 PF01471.18 AMD19122.1 - 0.039 14.2 0.1 0.18 12.0 0.0 2.1 2 0 0 2 2 2 0 Putative peptidoglycan binding domain TrkH PF02386.16 AMD19123.1 - 1.1e-153 512.4 6.3 1.1e-153 512.4 6.3 2.0 2 0 0 2 2 2 1 Cation transport protein HMG_box PF00505.19 AMD19124.1 - 8.4e-34 115.8 7.1 1.1e-18 67.4 0.5 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 AMD19124.1 - 2.5e-24 85.7 5.1 6.5e-12 45.9 0.4 2.2 1 1 1 2 2 2 2 HMG-box domain YABBY PF04690.13 AMD19124.1 - 3.3e-06 27.8 2.2 0.033 14.8 1.6 2.2 1 1 1 2 2 2 2 YABBY protein Protamine_like PF06382.11 AMD19124.1 - 3.7e-06 27.2 5.7 0.017 15.3 2.1 2.1 1 1 1 2 2 2 2 Protamine and protamine like CHDNT PF08073.12 AMD19124.1 - 1.3e-05 25.1 0.0 0.0012 18.8 0.0 2.3 2 0 0 2 2 2 1 CHDNT (NUC034) domain FAM195 PF14799.6 AMD19124.1 - 0.041 14.2 3.8 0.055 13.8 0.4 2.1 1 1 1 2 2 2 0 FAM195 family NUC PF18510.1 AMD19124.1 - 0.094 13.2 1.4 0.17 12.3 1.3 1.6 1 1 0 1 1 1 0 Nuclease domain GGACT PF06094.12 AMD19124.1 - 0.098 13.3 0.0 0.11 13.1 0.0 1.2 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like CRISPR_Cas6 PF10040.9 AMD19124.1 - 0.11 13.2 0.4 9.3 7.0 0.0 2.6 1 1 1 2 2 2 0 CRISPR-associated endoribonuclease Cas6 CPSase_L_D2 PF02786.17 AMD19125.1 - 1.6e-115 384.0 0.5 5.3e-84 280.9 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 AMD19125.1 - 1.8e-50 170.0 0.0 4.2e-50 168.9 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 AMD19125.1 - 3.6e-44 150.4 0.4 1.2e-43 148.6 0.1 2.1 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GATase PF00117.28 AMD19125.1 - 6.8e-43 146.6 0.0 1.6e-42 145.5 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 AMD19125.1 - 2.8e-39 134.2 0.1 8.2e-39 132.7 0.1 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 AMD19125.1 - 1.5e-29 103.1 0.1 1.8e-28 99.6 0.0 3.0 3 0 0 3 3 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 AMD19125.1 - 2.2e-21 75.8 0.0 2.6e-20 72.4 0.0 2.9 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.13 AMD19125.1 - 5.7e-18 65.2 2.2 1.7e-09 37.5 0.3 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AMD19125.1 - 1.9e-15 56.9 0.4 1.2e-07 31.5 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 AMD19125.1 - 3.3e-12 46.3 0.0 6.2e-07 29.2 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 AMD19125.1 - 3e-05 23.9 0.0 0.002 17.9 0.0 2.6 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 AMD19125.1 - 3.2e-05 24.0 0.7 0.19 11.8 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain TrkA_N PF02254.18 AMD19125.1 - 0.12 12.7 0.1 0.76 10.1 0.0 2.5 3 0 0 3 3 3 0 TrkA-N domain ATP-grasp_5 PF13549.6 AMD19125.1 - 0.13 11.7 0.2 13 5.2 0.1 2.4 2 0 0 2 2 2 0 ATP-grasp domain mIF3 PF14877.6 AMD19126.1 - 2.9e-48 163.9 2.5 2.9e-48 163.9 2.5 1.9 2 0 0 2 2 2 1 Mitochondrial translation initiation factor DUF4479 PF14794.6 AMD19126.1 - 0.031 14.1 0.4 0.086 12.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) Solute_trans_a PF03619.16 AMD19127.1 - 6.6e-73 245.5 16.7 8.4e-73 245.1 16.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Mito_carr PF00153.27 AMD19128.1 - 2.6e-60 200.4 1.1 5.3e-22 77.5 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein PAP2 PF01569.21 AMD19129.1 - 3.3e-16 59.3 2.2 7.3e-16 58.2 2.2 1.5 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 AMD19129.1 - 0.0064 16.6 0.1 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 Divergent PAP2 family Ndc1_Nup PF09531.10 AMD19129.1 - 0.069 11.8 0.1 0.16 10.6 0.1 1.7 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FUSC_2 PF13515.6 AMD19129.1 - 0.18 11.9 6.9 0.05 13.7 2.1 2.4 2 0 0 2 2 2 0 Fusaric acid resistance protein-like AAA_6 PF12774.7 AMD19130.1 - 5.8e-111 370.6 0.0 8e-110 366.8 0.0 2.9 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 AMD19130.1 - 5.8e-94 315.4 12.5 5.8e-94 315.4 12.5 5.6 7 0 0 7 7 6 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 AMD19130.1 - 3.6e-81 273.5 11.0 3.6e-81 273.5 11.0 3.2 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 AMD19130.1 - 4.4e-59 199.3 0.1 4.4e-59 199.3 0.1 3.5 2 0 0 2 2 1 1 ATP-binding dynein motor region AAA_8 PF12780.7 AMD19130.1 - 9.2e-46 156.3 0.6 6.4e-45 153.5 0.3 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 AMD19130.1 - 2.6e-43 147.6 0.5 2.4e-37 128.2 0.0 4.4 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 AMD19130.1 - 7e-29 100.9 6.8 1.6e-28 99.7 6.8 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 AMD19130.1 - 3.4e-24 85.4 0.0 5.5e-09 36.1 0.0 5.8 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 AMD19130.1 - 1.8e-22 79.9 0.1 8.8e-22 77.7 0.0 2.2 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 AMD19130.1 - 6.6e-15 55.3 0.1 4.7e-14 52.5 0.1 2.6 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 AMD19130.1 - 1.3e-13 51.5 0.0 0.015 15.7 0.0 5.1 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD19130.1 - 3.3e-13 50.1 2.6 0.00019 21.7 0.0 6.4 5 1 1 6 6 6 3 AAA domain AAA_18 PF13238.6 AMD19130.1 - 2.4e-10 41.0 0.1 0.099 13.2 0.0 5.4 4 0 0 4 4 4 3 AAA domain Dynein_AAA_lid PF17852.1 AMD19130.1 - 2.2e-08 34.3 0.1 1e-07 32.1 0.1 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_33 PF13671.6 AMD19130.1 - 8.2e-08 32.5 0.0 0.94 9.6 0.0 4.9 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.6 AMD19130.1 - 1.4e-07 32.0 0.3 1.3 9.4 0.0 5.3 4 0 0 4 4 4 3 AAA ATPase domain AAA_19 PF13245.6 AMD19130.1 - 3.3e-07 30.7 0.9 0.21 11.9 0.0 4.5 4 0 0 4 4 4 2 AAA domain AAA_lid_1 PF17857.1 AMD19130.1 - 1.1e-06 28.8 1.0 7.8e-06 26.0 0.1 3.1 3 0 0 3 3 2 1 AAA+ lid domain T2SSE PF00437.20 AMD19130.1 - 2.1e-06 27.0 12.1 0.012 14.7 0.0 4.9 6 0 0 6 6 5 2 Type II/IV secretion system protein AAA_14 PF13173.6 AMD19130.1 - 2.2e-06 27.7 3.9 0.27 11.3 0.0 6.3 6 0 0 6 6 6 1 AAA domain AAA_30 PF13604.6 AMD19130.1 - 0.00014 21.7 0.4 8.9 6.0 0.0 3.9 4 0 0 4 4 4 0 AAA domain Zeta_toxin PF06414.12 AMD19130.1 - 0.00039 19.8 0.0 0.086 12.1 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin AAA_25 PF13481.6 AMD19130.1 - 0.0011 18.6 0.2 0.28 10.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AMD19130.1 - 0.0017 18.1 5.9 1.7 8.4 0.0 4.5 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 AMD19130.1 - 0.0032 17.9 0.0 61 4.1 0.0 5.0 4 0 0 4 4 3 0 RNA helicase AAA_28 PF13521.6 AMD19130.1 - 0.0067 16.7 0.1 49 4.1 0.0 5.0 5 0 0 5 5 5 0 AAA domain AAA_29 PF13555.6 AMD19130.1 - 0.012 15.3 0.1 15 5.4 0.0 3.6 3 0 0 3 3 3 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 AMD19130.1 - 0.013 14.8 0.5 3.3 7.0 0.0 3.8 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 AMD19130.1 - 0.015 14.9 0.2 0.83 9.2 0.0 2.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 AMD19130.1 - 0.057 13.4 0.3 4.9 7.2 0.0 3.7 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CbiA PF01656.23 AMD19130.1 - 0.17 12.0 0.2 88 3.2 0.7 4.7 5 1 0 5 5 5 0 CobQ/CobB/MinD/ParA nucleotide binding domain RsgA_GTPase PF03193.16 AMD19130.1 - 0.27 11.1 5.2 8.9 6.2 0.0 4.5 5 0 0 5 5 4 0 RsgA GTPase ResIII PF04851.15 AMD19130.1 - 0.29 11.1 2.9 11 6.0 0.1 4.4 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit RNase_3_N PF18497.1 AMD19130.1 - 0.37 11.0 7.1 2 8.7 0.1 4.8 4 0 0 4 4 4 0 Ribonuclease III N-terminal domain ABC_tran PF00005.27 AMD19130.1 - 6.2 7.3 12.6 6.5 7.3 0.1 5.1 5 0 0 5 5 4 0 ABC transporter Ras PF00071.22 AMD19131.1 - 3e-45 153.7 0.0 3.8e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD19131.1 - 1.3e-23 83.4 0.0 1.6e-22 80.0 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD19131.1 - 1.1e-06 28.3 0.0 1.4e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD19131.1 - 0.014 14.8 0.0 0.092 12.1 0.0 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region tRNA_U5-meth_tr PF05958.11 AMD19132.1 - 2.1e-21 76.4 0.0 2.4e-20 72.8 0.0 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.20 AMD19132.1 - 1.1e-09 38.1 0.0 1.9e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 TRAM domain Methyltransf_31 PF13847.6 AMD19132.1 - 5.3e-08 32.8 0.0 1.6e-07 31.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD19132.1 - 3.5e-06 27.6 0.0 8.7e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 AMD19132.1 - 2.6e-05 23.8 0.0 5.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 AMD19132.1 - 3.4e-05 23.4 0.0 5.6e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 AMD19132.1 - 7e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 AMD19132.1 - 0.0024 17.4 0.0 0.005 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 AMD19132.1 - 0.024 14.0 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AMD19132.1 - 0.038 14.6 0.0 0.09 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 AMD19132.1 - 0.06 12.8 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Mak10 PF04112.13 AMD19133.1 - 1.7e-37 128.5 1.2 3.3e-37 127.6 1.2 1.5 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Ribosomal_L11_N PF03946.14 AMD19134.1 - 6.1e-22 77.2 0.4 1.9e-21 75.7 0.3 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AMD19134.1 - 5.9e-15 55.5 1.1 1.1e-14 54.6 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain ALS_ss_C PF10369.9 AMD19134.1 - 0.1 12.8 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Small subunit of acetolactate synthase ACBP PF00887.19 AMD19135.1 - 4.3e-18 65.3 0.0 1e-17 64.1 0.0 1.7 2 0 0 2 2 2 1 Acyl CoA binding protein IMS PF00817.20 AMD19136.1 - 1.8e-41 141.6 0.0 3.2e-41 140.8 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 AMD19136.1 - 3.7e-08 32.8 1.2 4.6e-08 32.5 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 AMD19136.1 - 0.018 15.5 0.1 0.046 14.1 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD19136.1 - 0.018 15.3 0.1 0.04 14.2 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding IMS_HHH PF11798.8 AMD19136.1 - 0.052 13.9 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 IMS family HHH motif MAP65_ASE1 PF03999.12 AMD19137.1 - 1.9e-87 294.4 44.6 1.9e-87 294.4 44.6 2.3 2 1 1 3 3 3 1 Microtubule associated protein (MAP65/ASE1 family) Med22 PF06179.12 AMD19137.1 - 0.01 16.0 1.2 0.096 12.9 1.2 2.8 1 0 0 1 1 1 0 Surfeit locus protein 5 subunit 22 of Mediator complex DUF5105 PF17118.5 AMD19137.1 - 0.4 10.4 6.3 0.16 11.8 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5105) Spore_III_AB PF09548.10 AMD19137.1 - 2.5 8.2 12.8 0.073 13.2 0.6 3.1 2 1 2 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) SGS PF05002.15 AMD19138.1 - 1.4e-27 95.6 0.2 5e-27 93.8 0.2 2.0 1 0 0 1 1 1 1 SGS domain CS PF04969.16 AMD19138.1 - 7.3e-10 39.7 0.7 1.5e-09 38.7 0.7 1.6 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 AMD19138.1 - 0.0029 17.6 5.3 1 9.7 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD19138.1 - 0.015 15.6 1.6 1.2 9.5 0.3 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 AMD19138.1 - 0.021 15.6 0.1 0.29 12.0 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 AMD19138.1 - 0.095 13.4 2.1 4.2 8.1 0.1 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 AMD19138.1 - 2.7 8.0 5.3 1.3 9.0 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat PIN_6 PF17146.4 AMD19139.1 - 3.4e-29 101.2 0.1 1.2e-28 99.4 0.0 2.0 2 0 0 2 2 2 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 AMD19139.1 - 1.3e-23 83.0 0.3 2.3e-23 82.1 0.3 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_9 PF14369.6 AMD19139.1 - 0.05 13.9 0.6 0.14 12.5 0.6 1.7 1 0 0 1 1 1 0 zinc-ribbon Prp31_C PF09785.9 AMD19139.1 - 0.13 13.2 7.4 2.4 9.1 2.7 2.8 3 0 0 3 3 3 0 Prp31 C terminal domain PIN_5 PF08745.11 AMD19139.1 - 0.17 11.3 4.3 8.1 5.8 0.0 3.2 3 1 1 4 4 4 0 PINc domain ribonuclease Flavoprotein PF02441.19 AMD19140.1 - 9.3e-51 171.7 0.1 1.4e-50 171.1 0.1 1.3 1 0 0 1 1 1 1 Flavoprotein RRN3 PF05327.11 AMD19140.1 - 0.0066 15.0 17.0 0.012 14.1 17.0 1.4 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 PPP4R2 PF09184.11 AMD19140.1 - 0.03 13.9 21.0 0.081 12.5 21.0 1.8 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 AMD19140.1 - 0.05 11.8 30.9 0.07 11.3 30.9 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 AMD19140.1 - 2.2 7.0 9.9 3.5 6.3 9.9 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop53 PF07767.11 AMD19140.1 - 3.5 6.9 19.8 6.1 6.1 19.8 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF5580 PF17743.1 AMD19140.1 - 5.1 5.5 7.3 0.57 8.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5580) Vfa1 PF08432.10 AMD19140.1 - 6.1 7.1 13.5 16 5.8 13.5 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 AMD19140.1 - 6.1 5.7 6.1 15 4.5 6.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Slu7 PF11708.8 AMD19140.1 - 8.3 6.1 20.4 14 5.3 20.4 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Cwf_Cwc_15 PF04889.12 AMD19140.1 - 9.7 5.8 40.2 21 4.7 40.2 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CIAPIN1 PF05093.13 AMD19141.1 - 8e-38 129.0 1.8 1.3e-37 128.3 1.8 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 AMD19141.1 - 6.5e-26 91.1 0.1 1.1e-25 90.4 0.1 1.4 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus zf-AN1 PF01428.16 AMD19142.1 - 4.6e-11 42.7 7.5 4.6e-11 42.7 7.5 1.4 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 AMD19142.1 - 0.042 14.2 6.9 0.068 13.5 6.9 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain HMG_CoA_synt_C PF08540.10 AMD19142.1 - 0.14 11.7 0.0 0.15 11.6 0.0 1.2 1 1 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal Hydrolase_6 PF13344.6 AMD19143.1 - 2.4e-23 82.1 0.0 8.2e-23 80.4 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AMD19143.1 - 8.1e-23 80.3 0.0 1.8e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AMD19143.1 - 0.00056 20.3 0.0 0.11 12.8 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AMD19143.1 - 0.00082 19.5 0.2 0.068 13.3 0.0 2.8 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase TP_methylase PF00590.20 AMD19144.1 - 1.4e-43 149.3 0.1 2.2e-43 148.7 0.1 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_M PF14824.6 AMD19144.1 - 5.7e-09 35.3 0.0 1.1e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central NAD_binding_7 PF13241.6 AMD19144.1 - 9.2e-07 29.3 0.0 2.2e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Nro1 PF12753.7 AMD19145.1 - 1e-145 485.9 11.0 1.1e-145 485.7 11.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 FAST_1 PF06743.15 AMD19145.1 - 0.0017 18.2 0.0 0.035 14.0 0.0 2.6 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 1 TPR_19 PF14559.6 AMD19145.1 - 0.0043 17.5 0.5 1.5 9.3 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat FCD PF07729.12 AMD19145.1 - 0.094 13.1 0.1 13 6.2 0.0 2.5 2 0 0 2 2 2 0 FCD domain TRAPP PF04051.16 AMD19146.1 - 5.5e-31 107.2 0.0 8.5e-31 106.6 0.0 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Dsl1_N PF11988.8 AMD19146.1 - 0.056 12.4 0.0 0.26 10.2 0.0 1.9 2 0 0 2 2 2 0 Retrograde transport protein Dsl1 N terminal DUF4541 PF15074.6 AMD19146.1 - 0.19 12.4 0.0 0.32 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4541) Methyltransf_28 PF02636.17 AMD19147.1 - 0.00012 21.9 0.1 0.00017 21.3 0.1 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase XRN_M PF17846.1 AMD19148.1 - 7.2e-128 427.3 0.1 1.2e-123 413.4 0.1 3.3 1 1 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 AMD19148.1 - 3.8e-99 331.0 0.2 5.4e-98 327.3 0.0 2.5 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus TraF PF13728.6 AMD19148.1 - 0.47 10.2 4.3 1.2 8.9 4.3 1.6 1 0 0 1 1 1 0 F plasmid transfer operon protein STD1 PF17235.2 AMD19149.1 - 5e-61 205.9 0.1 6.5e-61 205.6 0.1 1.1 1 0 0 1 1 1 1 STD1/MTH1 DEAD PF00270.29 AMD19150.1 - 1.4e-33 116.1 0.4 2.5e-33 115.3 0.1 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19150.1 - 4.9e-29 100.9 0.0 9.8e-29 99.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 AMD19150.1 - 0.0075 16.0 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Pmp3 PF01679.17 AMD19151.1 - 2e-16 59.9 11.3 2.2e-16 59.8 11.3 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator BTP PF05232.12 AMD19151.1 - 0.06 13.4 3.5 0.076 13.1 3.5 1.2 1 0 0 1 1 1 0 Chlorhexidine efflux transporter NapE PF06796.11 AMD19151.1 - 7.8 6.1 7.8 0.42 10.2 1.7 1.8 1 1 1 2 2 2 0 Periplasmic nitrate reductase protein NapE Tom6 PF17112.5 AMD19152.1 - 2.5e-26 90.9 0.8 2.8e-26 90.7 0.8 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal DUF4021 PF13213.6 AMD19152.1 - 0.7 9.9 1.9 1.1 9.3 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4021) CUE PF02845.16 AMD19155.1 - 4.8e-08 32.6 0.0 4.8e-08 32.6 0.0 1.9 2 0 0 2 2 2 1 CUE domain HAGH_C PF16123.5 AMD19156.1 - 5.2e-17 62.1 0.1 9.3e-17 61.3 0.1 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 AMD19156.1 - 1.1e-10 41.9 0.1 2.3e-07 31.0 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AMD19156.1 - 0.02 14.4 0.2 0.039 13.5 0.2 1.6 1 1 0 1 1 1 0 Beta-lactamase superfamily domain WD40 PF00400.32 AMD19157.1 - 0.00028 21.6 1.0 8.9 7.4 0.0 6.1 7 0 0 7 7 7 1 WD domain, G-beta repeat E1-E2_ATPase PF00122.20 AMD19158.1 - 2.1e-46 157.7 0.3 2.1e-46 157.7 0.3 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AMD19158.1 - 1.6e-26 93.9 0.0 4.1e-26 92.6 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 AMD19158.1 - 2.3e-14 53.5 4.2 1.8e-13 50.7 0.4 2.6 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 AMD19158.1 - 0.0049 16.6 0.1 0.044 13.5 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CK_II_beta PF01214.18 AMD19159.1 - 1.6e-71 239.9 0.0 1.9e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit RecG_N PF17190.4 AMD19159.1 - 0.13 13.0 1.0 0.29 11.9 0.4 1.8 2 0 0 2 2 2 0 RecG N-terminal helical domain Hira PF07569.11 AMD19160.1 - 1.9e-86 289.3 0.6 2.5e-84 282.4 0.1 3.2 3 0 0 3 3 3 1 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 AMD19160.1 - 0.0045 17.3 0.1 3.2 8.1 0.0 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Mcl1_mid PF12341.8 AMD19160.1 - 0.011 15.1 0.2 0.03 13.7 0.0 1.8 2 0 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region AGOG PF09171.10 AMD19160.1 - 2.4 7.4 5.6 8 5.7 5.6 1.8 1 1 0 1 1 1 0 N-glycosylase/DNA lyase tRNA-synt_1b PF00579.25 AMD19161.1 - 1e-76 258.1 0.2 1.3e-76 257.8 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) FAD_binding_6 PF00970.24 AMD19162.1 - 2.3e-06 27.9 0.0 0.0002 21.7 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_9 PF08021.11 AMD19162.1 - 0.17 12.1 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Tudor_3 PF18115.1 AMD19162.1 - 0.19 11.6 0.6 16 5.4 0.0 2.4 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain WD40 PF00400.32 AMD19163.1 - 1.9e-37 126.6 24.1 2.1e-07 31.5 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19163.1 - 4.5e-13 49.3 7.7 0.00016 21.9 0.0 5.7 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD19163.1 - 4.4e-05 23.4 0.3 0.036 14.0 0.0 3.4 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A YmzC PF14157.6 AMD19163.1 - 0.022 14.9 0.0 0.092 12.8 0.0 2.1 1 0 0 1 1 1 0 YmzC-like protein Coatomer_WDAD PF04053.14 AMD19163.1 - 0.035 13.1 3.5 0.072 12.1 0.7 2.5 3 1 1 4 4 4 0 Coatomer WD associated region IKI3 PF04762.12 AMD19163.1 - 0.043 11.8 1.6 1.6 6.7 0.7 2.2 2 0 0 2 2 2 0 IKI3 family Syntaxin_2 PF14523.6 AMD19164.1 - 1.4e-15 57.5 16.3 1.6e-15 57.3 7.2 2.7 2 1 1 3 3 3 2 Syntaxin-like protein SNARE PF05739.19 AMD19164.1 - 3.9e-14 52.4 0.6 1.2e-13 50.8 0.1 2.1 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 AMD19164.1 - 4.6e-05 23.2 12.2 7.2e-05 22.6 12.2 1.3 1 0 0 1 1 1 1 Syntaxin CK2S PF15011.6 AMD19164.1 - 0.028 14.3 4.8 0.76 9.6 2.3 2.2 2 0 0 2 2 2 0 Casein Kinase 2 substrate WXG100 PF06013.12 AMD19164.1 - 0.036 14.3 5.8 2.3 8.5 0.1 4.1 3 2 2 5 5 5 0 Proteins of 100 residues with WXG SIR2 PF02146.17 AMD19164.1 - 0.087 12.8 2.1 0.1 12.5 0.4 1.8 1 1 0 2 2 2 0 Sir2 family STAT_alpha PF01017.20 AMD19164.1 - 0.14 12.0 16.6 2.5 8.0 0.0 3.5 1 1 2 3 3 3 0 STAT protein, all-alpha domain DASH_Dad2 PF08654.10 AMD19164.1 - 1.2 9.5 10.4 2.8e+02 2.0 8.8 2.6 2 1 0 2 2 2 0 DASH complex subunit Dad2 Fib_alpha PF08702.10 AMD19164.1 - 8.1 6.6 14.8 2.2 8.5 6.3 2.5 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family OppC_N PF12911.7 AMD19165.1 - 0.11 12.5 0.9 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Prp18 PF02840.15 AMD19166.1 - 0.097 12.7 0.5 0.5 10.4 0.0 2.4 2 0 0 2 2 2 0 Prp18 domain SHS2_FTSA PF02491.20 AMD19166.1 - 0.19 12.1 0.5 0.45 10.9 0.1 1.8 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA Pkinase PF00069.25 AMD19167.1 - 2.4e-67 227.1 0.0 3.5e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19167.1 - 4.1e-52 177.0 0.0 5.9e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD19167.1 - 4.8e-09 35.5 0.0 3.7e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 AMD19167.1 - 0.00014 21.3 0.7 0.0017 17.7 0.0 2.5 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 AMD19167.1 - 0.00079 19.4 0.1 0.46 10.4 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AMD19167.1 - 0.012 14.6 1.4 0.32 9.9 1.4 2.4 1 1 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 AMD19167.1 - 0.21 11.2 0.2 0.68 9.5 0.0 1.8 1 1 1 2 2 2 0 RIO1 family Kdo PF06293.14 AMD19167.1 - 0.23 10.8 0.1 0.4 10.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FSA_C PF10479.9 AMD19167.1 - 1.7 6.7 8.3 4.3 5.4 8.3 1.6 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SBE2 PF17076.5 AMD19168.1 - 5.1e-164 547.7 27.3 7e-163 543.9 27.3 2.4 1 1 0 1 1 1 1 SBE2, cell-wall formation PQ-loop PF04193.14 AMD19169.1 - 7e-31 105.8 12.5 2.1e-15 56.2 2.8 2.6 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 AMD19169.1 - 1.9 8.6 10.8 0.52 10.4 0.7 3.5 3 1 0 3 3 3 0 Sugar efflux transporter for intercellular exchange PX PF00787.24 AMD19170.1 - 1.1e-16 60.8 0.0 1.4e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 PX domain Gal11_ABD1 PF18535.1 AMD19170.1 - 0.087 12.9 0.1 0.56 10.3 0.1 2.0 2 0 0 2 2 2 0 Gal11 activator-binding domain (ABD1) Pyr_redox_2 PF07992.14 AMD19171.1 - 1.5e-51 175.4 0.1 1.7e-51 175.2 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AMD19171.1 - 1.4e-19 70.5 0.1 3.7e-17 62.6 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AMD19171.1 - 2.3e-16 59.9 0.1 5.2e-15 55.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 AMD19171.1 - 9.8e-06 24.9 2.7 1.1 8.3 0.2 4.3 3 2 1 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 AMD19171.1 - 0.00012 22.4 0.0 0.11 13.0 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.6 AMD19171.1 - 0.00018 21.6 0.1 0.031 14.5 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 AMD19171.1 - 0.0052 15.9 3.7 1.9 7.5 0.3 3.3 3 1 1 4 4 4 2 FAD binding domain K_oxygenase PF13434.6 AMD19171.1 - 0.025 13.7 0.1 0.55 9.3 0.0 2.8 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 AMD19171.1 - 0.026 13.7 0.0 0.11 11.8 0.0 2.0 2 0 0 2 2 2 0 Thi4 family FAD_oxidored PF12831.7 AMD19171.1 - 0.038 13.3 0.2 5.7 6.2 0.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 AMD19171.1 - 0.081 13.0 0.2 3.7 7.6 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 AMD19171.1 - 0.081 12.2 0.0 6.1 6.0 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 AMD19171.1 - 0.11 12.2 0.1 0.62 9.7 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NAD_binding_9 PF13454.6 AMD19171.1 - 0.13 12.3 0.0 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Septin PF00735.18 AMD19172.1 - 6.8e-113 376.6 0.0 9.5e-113 376.1 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AMD19172.1 - 2e-05 24.6 0.0 4.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 AMD19172.1 - 0.0004 20.7 0.3 0.011 16.1 0.2 2.7 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 AMD19172.1 - 0.0028 17.6 5.3 0.0032 17.4 0.1 3.0 3 1 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 AMD19172.1 - 0.01 15.4 0.2 1.4 8.5 0.0 3.0 2 2 0 3 3 3 0 Elongation factor Tu GTP binding domain Roc PF08477.13 AMD19172.1 - 0.025 14.8 0.2 0.062 13.5 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 AMD19172.1 - 0.033 13.9 0.4 0.1 12.3 0.4 2.0 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 AMD19172.1 - 0.074 13.1 3.9 16 5.5 0.1 3.2 2 1 1 3 3 3 0 Dynamin family AAA_16 PF13191.6 AMD19172.1 - 0.087 13.2 0.1 0.39 11.1 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 AMD19172.1 - 0.12 12.8 0.0 0.38 11.1 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Glycos_transf_3 PF00591.21 AMD19173.1 - 3.3e-66 223.5 0.0 4.9e-66 222.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 AMD19173.1 - 2.5e-06 27.2 0.0 4.2e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain DUF3095 PF11294.8 AMD19173.1 - 0.024 13.7 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) Methyltransf_16 PF10294.9 AMD19174.1 - 2.6e-25 89.1 0.0 4.1e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 AMD19174.1 - 8.3e-08 32.2 0.0 1.4e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD19174.1 - 4.7e-07 29.8 0.0 8.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AMD19174.1 - 8.5e-05 22.3 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 AMD19174.1 - 0.00013 21.6 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 AMD19174.1 - 0.00022 21.9 0.0 0.00076 20.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD19174.1 - 0.00085 20.0 0.0 0.0016 19.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AMD19174.1 - 0.019 14.7 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TRM PF02005.16 AMD19174.1 - 0.047 12.8 0.0 0.068 12.3 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_11 PF08241.12 AMD19174.1 - 0.1 13.2 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Spc110_C PF18520.1 AMD19175.1 - 6e-25 86.6 2.6 3.1e-24 84.3 2.6 2.4 1 0 0 1 1 1 1 Spindle pole body component 110 C-terminal domain DHR10 PF18595.1 AMD19175.1 - 5.5e-05 23.2 13.2 5.5e-05 23.2 13.2 8.9 2 2 5 8 8 8 2 Designed helical repeat protein 10 domain CCDC144C PF14915.6 AMD19175.1 - 6.1e-05 22.3 27.5 6.1e-05 22.3 27.5 4.9 1 1 3 4 4 4 1 CCDC144C protein coiled-coil region Cnn_1N PF07989.11 AMD19175.1 - 0.0006 19.9 7.1 0.0006 19.9 7.1 10.6 5 1 5 10 10 10 1 Centrosomin N-terminal motif 1 GAS PF13851.6 AMD19175.1 - 0.0012 18.3 25.8 0.0012 18.3 25.8 7.2 2 1 4 6 6 5 1 Growth-arrest specific micro-tubule binding ADIP PF11559.8 AMD19175.1 - 0.012 15.7 10.9 0.012 15.7 10.9 7.3 1 1 4 7 7 7 0 Afadin- and alpha -actinin-Binding PACT_coil_coil PF10495.9 AMD19175.1 - 0.14 12.8 0.1 0.14 12.8 0.1 3.9 3 1 1 4 4 4 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein UvrC_HhH_N PF08459.11 AMD19175.1 - 0.14 12.0 4.6 1.1 9.2 0.1 3.9 3 0 0 3 3 3 0 UvrC Helix-hairpin-helix N-terminal UPF0147 PF03685.13 AMD19175.1 - 0.2 11.8 3.2 0.77 9.8 0.0 3.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0147) DUF5344 PF17279.2 AMD19175.1 - 2.7 8.6 36.4 0.093 13.3 1.0 6.7 3 2 3 6 6 6 0 Family of unknown function (DUF5344) DUF4407 PF14362.6 AMD19175.1 - 3.3 7.0 55.3 0.14 11.5 13.2 5.0 1 1 4 5 5 5 0 Domain of unknown function (DUF4407) PSI_PsaF PF02507.15 AMD19175.1 - 5 6.9 7.5 2 8.3 0.1 3.4 3 0 0 3 3 3 0 Photosystem I reaction centre subunit III TACC_C PF05010.14 AMD19175.1 - 8.8 6.1 92.8 2 8.2 21.3 6.2 2 1 2 5 5 5 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF5100 PF17029.5 AMD19176.1 - 0.044 13.6 0.8 0.044 13.6 0.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5100) DUF5617 PF18493.1 AMD19176.1 - 0.084 13.0 2.5 1.9 8.6 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5617) VHS PF00790.19 AMD19177.1 - 5.2e-45 152.8 0.1 1.5e-44 151.3 0.0 1.8 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 AMD19177.1 - 2.1e-21 76.3 0.1 2.1e-21 76.3 0.1 2.5 2 0 0 2 2 1 1 Adaptin C-terminal domain GAT PF03127.14 AMD19177.1 - 3.9e-19 68.7 3.0 2e-18 66.5 3.0 2.3 1 0 0 1 1 1 1 GAT domain GGA_N-GAT PF18308.1 AMD19177.1 - 6.9e-06 25.6 0.4 2e-05 24.1 0.4 1.9 1 0 0 1 1 1 1 GGA N-GAT domain Spt20 PF12090.8 AMD19177.1 - 0.00074 19.2 16.1 0.0016 18.1 16.1 1.6 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 AMD19177.1 - 0.0013 18.9 16.7 0.0013 18.9 16.7 1.8 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 AMD19177.1 - 0.0036 16.1 16.8 0.0048 15.6 16.8 1.2 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Dehydratase_SU PF02287.15 AMD19177.1 - 0.012 15.7 0.3 0.04 14.0 0.3 2.0 1 1 0 1 1 1 0 Dehydratase small subunit Presenilin PF01080.17 AMD19177.1 - 0.068 11.9 3.1 0.096 11.4 3.1 1.2 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 AMD19177.1 - 0.14 10.6 2.5 0.28 9.6 2.5 1.4 1 0 0 1 1 1 0 FHIPEP family TCRP1 PF14944.6 AMD19177.1 - 0.15 12.0 2.8 0.24 11.3 2.8 1.2 1 0 0 1 1 1 0 Tongue Cancer Chemotherapy Resistant Protein 1 TMEM51 PF15345.6 AMD19177.1 - 0.35 10.7 9.9 0.64 9.8 9.9 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4834 PF16118.5 AMD19177.1 - 2.9 8.9 9.4 7.5 7.6 9.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Zip PF02535.22 AMD19177.1 - 3.2 6.9 5.5 5 6.3 5.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter EPL1 PF10513.9 AMD19177.1 - 3.4 8.0 12.6 0.29 11.5 6.7 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like SPARC_Ca_bdg PF10591.9 AMD19177.1 - 4 7.8 9.0 1.2 9.5 4.7 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region MMR1 PF08505.10 AMD19177.1 - 5.7 7.1 15.6 0.29 11.4 9.9 1.7 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein HD-ZIP_N PF04618.12 AMD19177.1 - 6.8 7.3 6.6 44 4.6 3.1 2.9 3 0 0 3 3 2 0 HD-ZIP protein N terminus ALMT PF11744.8 AMD19177.1 - 8.6 5.1 7.2 0.39 9.5 1.5 1.5 2 0 0 2 2 2 0 Aluminium activated malate transporter HSA PF07529.13 AMD19178.1 - 2.7e-11 43.6 0.6 2.7e-11 43.6 0.6 2.8 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.6 AMD19178.1 - 1.7e-09 37.8 1.3 1.7e-09 37.8 1.3 2.8 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 AMD19178.1 - 0.00064 19.9 0.1 0.0021 18.2 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 AMD19178.1 - 0.042 14.2 0.5 0.23 11.9 0.5 2.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain BCIP PF13862.6 AMD19179.1 - 8.1e-47 159.7 1.9 1.2e-46 159.1 1.9 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein YL1 PF05764.13 AMD19179.1 - 3.7 7.6 12.5 0.57 10.3 0.6 2.1 2 0 0 2 2 2 0 YL1 nuclear protein EMP24_GP25L PF01105.24 AMD19181.1 - 1.6e-33 116.1 0.0 1.9e-33 115.9 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RIO1 PF01163.22 AMD19182.1 - 1.7e-42 145.2 0.8 2.7e-42 144.5 0.8 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 AMD19182.1 - 1.4e-30 105.4 0.1 4e-30 103.9 0.1 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 AMD19182.1 - 1.1e-07 32.0 0.0 0.016 15.2 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 AMD19182.1 - 0.00014 21.3 0.3 0.0021 17.4 0.3 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 AMD19182.1 - 0.0064 15.3 0.0 0.009 14.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 AMD19182.1 - 0.0092 15.4 0.6 0.018 14.4 0.6 1.5 1 1 0 1 1 1 1 Protein kinase domain DNA_pol_phi PF04931.13 AMD19182.1 - 5.9 4.9 10.4 8.2 4.4 10.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi PH_18 PF18469.1 AMD19183.1 - 4.1e-43 146.8 1.1 4.1e-43 146.8 1.1 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Rtt106 PF08512.12 AMD19183.1 - 3e-30 104.5 1.4 4.6e-30 103.9 0.4 1.9 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Rtt106_N PF18215.1 AMD19183.1 - 3.4e-08 33.1 0.0 8.8e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 Histone chaperone Rtt106 N-terminal domain SLC12 PF03522.15 AMD19183.1 - 0.016 14.3 5.8 0.023 13.8 5.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 POB3_N PF17292.2 AMD19183.1 - 0.036 14.5 0.1 0.085 13.3 0.1 1.6 1 0 0 1 1 1 0 POB3-like N-terminal PH domain PTPlike_phytase PF14566.6 AMD19183.1 - 0.19 11.8 2.8 19 5.4 0.0 2.7 2 0 0 2 2 2 0 Inositol hexakisphosphate Hid1 PF12722.7 AMD19183.1 - 8.5 4.4 13.4 13 3.7 13.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PNISR PF15996.5 AMD19183.1 - 8.6 6.6 21.2 14 5.9 21.2 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR ArfGap PF01412.18 AMD19184.1 - 9.6e-32 109.5 0.9 2.4e-31 108.2 0.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf ADD_DNMT3 PF17980.1 AMD19184.1 - 0.0092 16.0 0.8 6.1 6.9 0.5 2.3 2 0 0 2 2 2 2 Cysteine rich ADD domain in DNMT3 adh_short_C2 PF13561.6 AMD19185.1 - 3.2e-48 164.4 1.9 4.1e-48 164.0 1.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AMD19185.1 - 8.7e-36 123.2 1.4 1.1e-35 122.8 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AMD19185.1 - 2.4e-12 47.1 0.8 3.7e-12 46.5 0.8 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 AMD19185.1 - 0.082 13.2 0.9 0.16 12.2 0.9 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 AMD19185.1 - 0.14 11.5 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 AMD19185.1 - 0.14 11.5 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase SMK-1 PF04802.15 AMD19186.1 - 3.2e-53 180.4 8.0 3.2e-53 180.4 8.0 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 YjeF_N PF03853.15 AMD19187.1 - 2e-36 125.4 0.0 2.5e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus GOLGA2L5 PF15070.6 AMD19188.1 - 0.027 13.2 3.2 0.024 13.3 1.8 1.5 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 PKcGMP_CC PF16808.5 AMD19188.1 - 0.39 10.6 17.8 0.5 10.2 9.8 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Csm1_N PF18504.1 AMD19188.1 - 1.3 9.4 8.0 0.3 11.5 2.4 2.6 3 0 0 3 3 3 0 Csm1 N-terminal domain Septin PF00735.18 AMD19189.1 - 6.8e-76 255.2 4.7 7.2e-76 255.2 0.6 2.6 2 1 0 2 2 2 1 Septin AAA_33 PF13671.6 AMD19189.1 - 0.00022 21.4 0.2 0.0098 16.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 AMD19189.1 - 0.0017 17.9 0.3 0.011 15.2 0.0 2.2 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_24 PF13479.6 AMD19189.1 - 0.0042 16.8 0.0 0.012 15.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AMD19189.1 - 0.0086 16.2 0.0 1.1 9.3 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 AMD19189.1 - 0.0091 16.3 0.0 0.063 13.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 AMD19189.1 - 0.016 14.7 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 AMD19189.1 - 0.017 15.5 0.1 0.065 13.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 AMD19189.1 - 0.031 14.7 0.2 0.31 11.4 0.0 2.7 2 1 1 3 3 3 0 RNA helicase AIG1 PF04548.16 AMD19189.1 - 0.034 13.5 1.6 0.051 12.9 0.0 2.0 2 0 0 2 2 2 0 AIG1 family Sigma54_activat PF00158.26 AMD19189.1 - 0.048 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain MobB PF03205.14 AMD19189.1 - 0.059 13.3 0.1 2.9 7.8 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.18 AMD19189.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA PF00004.29 AMD19189.1 - 0.083 13.3 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AMD19189.1 - 0.097 12.7 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AMD19189.1 - 0.098 13.2 0.3 0.76 10.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AMD19189.1 - 0.12 12.3 2.2 0.17 11.7 0.0 2.3 3 0 0 3 3 2 0 RsgA GTPase LMBR1 PF04791.16 AMD19189.1 - 0.91 8.3 2.3 1.3 7.8 2.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF155 PF02582.14 AMD19190.1 - 4.4e-42 144.1 0.3 8.1e-42 143.3 0.3 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 RCC1_2 PF13540.6 AMD19190.1 - 0.13 12.1 0.1 0.42 10.5 0.0 1.8 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat FAD_binding_1 PF00667.20 AMD19191.1 - 1e-69 234.5 0.0 1.6e-69 233.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 AMD19191.1 - 8.5e-31 107.1 0.5 1.5e-30 106.3 0.5 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 AMD19191.1 - 1.3e-22 80.5 0.0 5.1e-22 78.6 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Spore_IV_A PF09547.10 AMD19191.1 - 5.5e-05 22.3 0.0 9.9e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Stage IV sporulation protein A (spore_IV_A) Flavodoxin_5 PF12724.7 AMD19191.1 - 0.0067 16.7 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin domain MAGE PF01454.19 AMD19192.1 - 7.7e-32 110.7 0.0 1.1e-31 110.2 0.0 1.2 1 0 0 1 1 1 1 MAGE family DUF836 PF05768.14 AMD19193.1 - 5e-15 55.7 0.6 6.3e-15 55.4 0.6 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 AMD19193.1 - 0.003 17.8 0.1 0.0049 17.1 0.1 1.5 1 1 0 1 1 1 1 Glutaredoxin DUF3069 PF11269.8 AMD19193.1 - 0.12 12.6 0.3 0.7 10.2 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3069) DELLA PF12041.8 AMD19194.1 - 0.027 14.3 3.2 0.16 11.9 0.2 3.2 3 0 0 3 3 3 0 Transcriptional regulator DELLA protein N terminal MCM_N PF14551.6 AMD19194.1 - 0.14 12.8 0.1 0.14 12.8 0.1 3.0 3 0 0 3 3 3 0 MCM N-terminal domain CALCOCO1 PF07888.11 AMD19194.1 - 0.7 8.7 67.4 0.17 10.7 22.8 3.4 1 1 3 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.8 AMD19194.1 - 0.85 9.7 68.8 0.87 9.7 8.1 6.9 4 1 2 6 6 6 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 AMD19194.1 - 0.9 10.0 69.9 0.71 10.3 6.4 5.4 1 1 5 6 6 6 0 Fez1 Golgin_A5 PF09787.9 AMD19194.1 - 1.6 8.1 77.0 0.21 11.0 13.5 4.7 1 1 2 4 4 4 0 Golgin subfamily A member 5 SlyX PF04102.12 AMD19194.1 - 6.1 7.5 52.2 0.095 13.3 1.5 8.1 7 3 1 8 8 8 0 SlyX PAP2 PF01569.21 AMD19195.1 - 4.1e-24 84.9 2.2 8.6e-24 83.8 2.2 1.5 1 0 0 1 1 1 1 PAP2 superfamily MFS_1 PF07690.16 AMD19195.1 - 0.0084 15.1 0.3 0.0084 15.1 0.3 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily HGTP_anticodon2 PF12745.7 AMD19196.1 - 2e-85 286.5 1.1 2e-85 286.5 1.1 3.0 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 AMD19196.1 - 2.5e-70 236.8 13.2 7.1e-42 143.6 0.2 4.5 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19196.1 - 3.2e-39 134.8 0.6 4.5e-21 75.3 0.0 3.7 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 AMD19196.1 - 1.9e-17 63.6 0.4 1.9e-17 63.6 0.4 2.7 3 0 0 3 3 3 1 RWD domain tRNA-synt_His PF13393.6 AMD19196.1 - 1.3e-15 57.5 0.0 2.9e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Histidyl-tRNA synthetase FTA2 PF13095.6 AMD19196.1 - 0.0054 16.4 1.3 0.54 9.8 0.1 3.3 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 AMD19196.1 - 0.027 13.8 0.0 0.083 12.2 0.0 1.8 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD19196.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Med20 PF08612.11 AMD19197.1 - 7.2e-49 166.2 0.3 7.9e-49 166.0 0.3 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex CTD_bind PF04818.13 AMD19198.1 - 2.4e-17 63.5 3.6 2.6e-17 63.4 1.0 2.4 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.8 AMD19198.1 - 0.021 14.8 0.4 0.13 12.3 0.1 2.2 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 Cons_hypoth95 PF03602.15 AMD19198.1 - 0.17 11.5 1.0 0.26 10.9 0.1 1.8 2 0 0 2 2 2 0 Conserved hypothetical protein 95 AATF-Che1 PF13339.6 AMD19198.1 - 1.5 9.5 10.3 1.7 9.3 7.8 2.2 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor DEAD PF00270.29 AMD19199.1 - 4.1e-24 85.3 0.0 9.1e-24 84.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 AMD19199.1 - 1.4e-19 70.7 0.2 5.9e-19 68.6 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 AMD19199.1 - 6e-13 49.1 0.0 2.4e-12 47.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD19199.1 - 1.2e-08 35.2 0.0 2.8e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 AMD19199.1 - 0.015 15.6 1.5 0.035 14.4 1.5 1.5 1 0 0 1 1 1 0 DNA replication factor CDT1 like FAM184 PF15665.5 AMD19199.1 - 0.19 11.5 1.3 0.35 10.6 1.3 1.3 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B SRP54 PF00448.22 AMD19200.1 - 2.6e-46 157.7 0.1 1.4e-43 148.8 0.1 2.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRX PF09201.10 AMD19200.1 - 1.4e-43 148.3 0.5 3.5e-43 147.0 0.5 1.7 1 0 0 1 1 1 1 SRX, signal recognition particle receptor alpha subunit SRP-alpha_N PF04086.13 AMD19200.1 - 4.5e-07 30.1 4.5 4.5e-07 30.1 4.5 2.2 2 0 0 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 AMD19200.1 - 6e-07 29.6 1.2 2.6e-06 27.6 1.2 2.2 1 1 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 AMD19200.1 - 0.00027 20.0 0.0 0.00094 18.2 0.0 2.0 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ArsA_ATPase PF02374.15 AMD19200.1 - 0.0018 17.5 0.0 0.16 11.1 0.0 2.4 2 0 0 2 2 2 1 Anion-transporting ATPase CbiA PF01656.23 AMD19200.1 - 0.0049 16.9 0.0 0.014 15.5 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AMD19200.1 - 0.015 15.2 3.0 0.028 14.3 0.0 2.9 3 1 0 3 3 3 0 AAA domain AAA_22 PF13401.6 AMD19200.1 - 0.017 15.4 0.0 0.24 11.7 0.0 2.8 2 1 1 3 3 3 0 AAA domain Fer4_NifH PF00142.18 AMD19200.1 - 0.031 13.7 0.0 0.064 12.7 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_30 PF13604.6 AMD19200.1 - 0.075 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AMD19200.1 - 0.1 12.2 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AMD19200.1 - 0.14 12.5 0.1 0.68 10.3 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 AMD19200.1 - 7.2 6.6 7.2 3 7.9 0.2 3.1 4 0 0 4 4 4 0 Helicase HerA, central domain Cyt-b5 PF00173.28 AMD19201.1 - 1e-13 51.2 0.0 2.1e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 AMD19201.1 - 3e-09 37.1 9.0 5.7e-09 36.2 9.0 1.4 1 0 0 1 1 1 1 Fatty acid desaturase zf-HIT PF04438.16 AMD19202.1 - 3.1e-06 26.9 16.5 5.4e-06 26.2 16.5 1.4 1 0 0 1 1 1 1 HIT zinc finger DUF4598 PF15370.6 AMD19202.1 - 0.011 16.3 0.7 0.011 16.3 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) PolC_DP2 PF03833.13 AMD19202.1 - 0.81 7.5 6.9 1.1 7.0 6.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Cwf_Cwc_15 PF04889.12 AMD19202.1 - 1.1 8.9 6.5 2.1 8.0 6.5 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AF-4 PF05110.13 AMD19202.1 - 3.3 5.7 14.5 5 5.1 14.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein V-ATPase_G PF03179.15 AMD19203.1 - 8.5e-31 106.6 14.2 9.5e-31 106.5 14.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ASL_C2 PF14698.6 AMD19203.1 - 0.0098 16.6 1.0 0.015 16.0 1.0 1.5 1 1 0 1 1 1 1 Argininosuccinate lyase C-terminal DUF3552 PF12072.8 AMD19203.1 - 0.077 12.4 16.4 0.22 10.9 16.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) ATP-synt_B PF00430.18 AMD19203.1 - 0.13 12.4 17.1 0.25 11.4 17.1 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) FlgN PF05130.12 AMD19203.1 - 0.17 12.4 10.2 0.19 12.2 10.2 1.0 1 0 0 1 1 1 0 FlgN protein Aldedh PF00171.22 AMD19204.1 - 4.8e-124 414.4 0.0 6e-124 414.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family AA_permease_C PF13906.6 AMD19204.1 - 0.69 10.0 3.0 2.3 8.4 1.2 2.2 2 0 0 2 2 2 0 C-terminus of AA_permease RRF PF01765.19 AMD19205.1 - 1.2e-38 132.7 5.2 1.8e-38 132.1 5.2 1.3 1 0 0 1 1 1 1 Ribosome recycling factor DNA_pol_phi PF04931.13 AMD19205.1 - 0.0019 16.4 1.5 0.0023 16.2 1.5 1.1 1 0 0 1 1 1 1 DNA polymerase phi Uds1 PF15456.6 AMD19205.1 - 0.038 14.2 0.6 0.038 14.2 0.6 2.0 2 1 0 2 2 2 0 Up-regulated During Septation Tryp_alpha_amyl PF00234.22 AMD19205.1 - 0.083 13.3 0.2 0.14 12.6 0.2 1.5 1 0 0 1 1 1 0 Protease inhibitor/seed storage/LTP family Fzo_mitofusin PF04799.13 AMD19205.1 - 0.17 11.4 3.9 0.29 10.7 2.3 1.9 2 0 0 2 2 2 0 fzo-like conserved region NPV_P10 PF05531.12 AMD19205.1 - 0.24 11.9 3.8 0.5 10.9 2.6 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TPP_enzyme_N PF02776.18 AMD19206.1 - 4.4e-32 111.1 0.0 7.7e-32 110.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AMD19206.1 - 1.2e-28 99.5 0.0 5.7e-28 97.4 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AMD19206.1 - 5.2e-13 49.1 0.0 9.2e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain RNB PF00773.19 AMD19207.1 - 1.7e-56 192.0 2.2 3.1e-56 191.1 2.2 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 AMD19207.1 - 1.1e-23 83.0 0.1 2.7e-23 81.8 0.1 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 AMD19207.1 - 1.9e-20 72.9 0.8 4.7e-20 71.7 0.0 2.2 2 0 0 2 2 2 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 AMD19207.1 - 2.3e-07 30.8 0.0 0.00016 21.7 0.0 3.0 2 0 0 2 2 2 2 Cold shock domain OB_RNB PF08206.11 AMD19207.1 - 0.0002 21.0 0.2 0.27 10.9 0.1 2.8 3 0 0 3 3 3 2 Ribonuclease B OB domain Rrp44_CSD1 PF17216.3 AMD19207.1 - 0.0018 18.0 0.2 0.0041 16.8 0.2 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 AMD19207.1 - 0.066 13.2 0.0 0.31 11.0 0.0 2.2 1 1 0 1 1 1 0 S1 domain Aldedh PF00171.22 AMD19208.1 - 2.5e-105 352.7 0.0 2.9e-105 352.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Brr6_like_C_C PF10104.9 AMD19209.1 - 2e-40 137.6 0.2 3.2e-40 137.0 0.2 1.3 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Rtt106_N PF18215.1 AMD19209.1 - 0.11 12.3 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain HDA2-3 PF11496.8 AMD19210.1 - 4.2e-64 216.5 0.5 4.2e-64 216.5 0.5 2.0 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 BLOC1_2 PF10046.9 AMD19210.1 - 0.88 9.9 13.3 0.83 10.0 1.4 3.7 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Enkurin PF13864.6 AMD19210.1 - 3.4 8.2 23.3 14 6.2 14.7 3.1 1 1 1 2 2 2 0 Calmodulin-binding Laminin_II PF06009.12 AMD19210.1 - 8.4 6.4 20.6 1.3 9.0 5.1 3.3 2 1 1 3 3 3 0 Laminin Domain II Mhr1 PF12829.7 AMD19211.1 - 5.6e-24 84.0 0.4 1.4e-23 82.8 0.4 1.7 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination FA_hydroxylase PF04116.13 AMD19212.1 - 5.8e-22 78.5 15.8 7e-22 78.2 11.5 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily OSCP PF00213.18 AMD19213.1 - 2e-43 148.5 5.0 2.3e-43 148.3 5.0 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit dCache_1 PF02743.18 AMD19213.1 - 0.051 13.4 0.5 0.07 12.9 0.5 1.2 1 0 0 1 1 1 0 Cache domain AATF-Che1 PF13339.6 AMD19214.1 - 7.1e-24 85.1 8.6 7.1e-24 85.1 8.6 3.3 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 AMD19214.1 - 9.7e-23 80.5 0.0 9.7e-23 80.5 0.0 3.2 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal EIF_2_alpha PF07541.12 AMD19214.1 - 0.031 14.3 0.3 0.14 12.3 0.3 2.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit BSP_II PF05432.11 AMD19214.1 - 9.8 5.8 36.9 8.2 6.0 34.8 1.9 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) MatE PF01554.18 AMD19215.1 - 7.7e-52 175.2 24.3 3.9e-28 98.1 9.3 2.6 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 AMD19215.1 - 2.3e-08 34.2 11.5 2.3e-08 34.2 11.5 4.5 3 1 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain DUF983 PF06170.12 AMD19215.1 - 6.5 7.2 9.3 9.1 6.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF983) Pih1_fungal_CS PF18482.1 AMD19216.1 - 2e-27 95.5 2.2 3.4e-27 94.8 2.2 1.4 1 0 0 1 1 1 1 Fungal Pih1 CS domain PIH1 PF08190.12 AMD19216.1 - 1.5e-21 76.6 0.2 2.6e-21 75.8 0.2 1.3 1 0 0 1 1 1 1 PIH1 N-terminal domain AA_kinase PF00696.28 AMD19217.1 - 2.4e-35 122.3 0.4 4e-35 121.5 0.4 1.4 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 AMD19217.1 - 4.6e-21 74.6 0.0 9.4e-21 73.6 0.0 1.6 1 0 0 1 1 1 1 PUA domain CPSF_A PF03178.15 AMD19218.1 - 2e-89 300.1 0.1 5.9e-89 298.6 0.0 1.9 2 0 0 2 2 2 1 CPSF A subunit region HPS3_N PF14761.6 AMD19218.1 - 0.018 14.6 0.2 1.6 8.2 0.0 3.0 3 0 0 3 3 3 0 Hermansky-Pudlak syndrome 3 G-7-MTase PF12803.7 AMD19218.1 - 0.072 12.2 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) PIG-F PF06699.11 AMD19219.1 - 4e-24 85.8 18.5 5.5e-23 82.1 18.5 2.0 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F TauE PF01925.19 AMD19219.1 - 0.0022 17.7 0.9 0.003 17.2 0.9 1.3 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE AIM24 PF01987.17 AMD19220.1 - 5.3e-13 49.2 0.1 7.4e-13 48.8 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Zn_clus PF00172.18 AMD19221.1 - 2.7e-08 33.8 8.5 5.3e-08 32.9 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rox3 PF08633.10 AMD19221.1 - 0.13 12.5 0.3 0.22 11.8 0.3 1.3 1 0 0 1 1 1 0 Rox3 mediator complex subunit Pro_isomerase PF00160.21 AMD19222.1 - 7.6e-46 156.3 0.1 9e-46 156.0 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med6 PF04934.14 AMD19223.1 - 1.2e-51 174.0 0.1 1.5e-51 173.7 0.1 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component CoA_trans PF01144.23 AMD19223.1 - 0.097 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase DUF4620 PF15399.6 AMD19223.1 - 0.28 11.5 1.8 0.53 10.7 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4620) IGR PF09597.10 AMD19224.1 - 5.2e-24 84.1 0.1 9.3e-24 83.3 0.1 1.4 1 0 0 1 1 1 1 IGR protein motif HIT PF01230.23 AMD19225.1 - 1.9e-24 86.2 0.1 3.3e-24 85.4 0.1 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AMD19225.1 - 0.001 19.6 0.4 0.0016 18.9 0.4 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding ABC_tran_CTD PF16326.5 AMD19225.1 - 0.017 15.3 0.4 0.027 14.7 0.4 1.2 1 0 0 1 1 1 0 ABC transporter C-terminal domain CwfJ_C_1 PF04677.15 AMD19225.1 - 0.053 13.4 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 F-box-like PF12937.7 AMD19226.1 - 0.28 11.1 6.0 0.057 13.3 1.6 2.2 2 0 0 2 2 2 0 F-box-like Med21 PF11221.8 AMD19228.1 - 5.8e-39 133.6 1.2 7.2e-39 133.3 1.2 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 AMD19228.1 - 0.022 14.8 0.5 0.13 12.4 0.0 2.4 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Spore_III_AB PF09548.10 AMD19228.1 - 0.099 12.7 0.2 0.15 12.1 0.2 1.4 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) RNase_P_p30 PF01876.16 AMD19231.1 - 1.9e-65 220.4 0.2 2.3e-65 220.1 0.2 1.1 1 0 0 1 1 1 1 RNase P subunit p30 NOA36 PF06524.12 AMD19232.1 - 2 7.7 15.8 5.1 6.3 15.8 1.7 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 AMD19232.1 - 9.5 4.2 18.6 18 3.3 18.6 1.5 1 0 0 1 1 1 0 DNA polymerase phi ApbA PF02558.16 AMD19233.1 - 1.4e-30 105.9 0.0 2.1e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 AMD19233.1 - 6.5e-25 87.7 0.1 1.1e-24 87.1 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal HSP70 PF00012.20 AMD19234.1 - 3.3e-79 266.7 4.0 1.7e-78 264.3 1.7 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 AMD19234.1 - 7.4e-12 44.7 0.0 1.3e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Pox_I6 PF04595.13 AMD19234.1 - 0.02 13.8 0.1 0.075 12.0 0.1 1.9 1 1 1 2 2 2 0 Poxvirus I6-like family BSD PF03909.17 AMD19235.1 - 7.6e-22 77.1 5.4 2e-11 43.7 0.6 3.1 3 0 0 3 3 3 2 BSD domain PH_TFIIH PF08567.11 AMD19235.1 - 6.7e-19 68.0 0.5 1.6e-18 66.8 0.1 1.9 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain GAT PF03127.14 AMD19235.1 - 0.69 10.3 0.0 0.69 10.3 0.0 4.2 5 0 0 5 5 5 0 GAT domain DEAD PF00270.29 AMD19236.1 - 8.9e-50 168.9 0.0 1.8e-49 167.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19236.1 - 2.6e-30 105.0 0.0 1.5e-29 102.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD19236.1 - 6.1e-07 29.6 0.0 2e-06 27.9 0.0 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 AMD19236.1 - 0.0057 17.0 0.0 0.04 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain SWI2_SNF2 PF18766.1 AMD19236.1 - 0.022 14.4 0.4 0.048 13.3 0.0 1.7 2 0 0 2 2 2 0 SWI2/SNF2 ATPase Brix PF04427.18 AMD19237.1 - 2.4e-51 174.6 1.0 4e-51 173.9 1.0 1.3 1 0 0 1 1 1 1 Brix domain Arcadin_1 PF18653.1 AMD19237.1 - 0.012 15.7 0.3 0.012 15.7 0.3 2.3 4 0 0 4 4 4 0 Arcadin 1 ATP-synt_E PF05680.12 AMD19237.1 - 0.38 11.1 9.0 1.6 9.1 9.0 2.2 1 0 0 1 1 1 0 ATP synthase E chain DUF4692 PF15763.5 AMD19237.1 - 1.1 9.7 4.9 2.6 8.5 4.9 1.6 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) FYVE PF01363.21 AMD19238.1 - 7e-18 64.5 12.5 7e-18 64.5 12.5 3.5 3 1 1 4 4 4 1 FYVE zinc finger zf-RING_2 PF13639.6 AMD19238.1 - 6.2e-07 29.7 3.9 6.2e-07 29.7 3.9 4.2 3 1 1 4 4 4 2 Ring finger domain zf-RING_UBOX PF13445.6 AMD19238.1 - 0.0012 18.9 2.1 0.0012 18.9 2.1 4.1 4 0 0 4 4 4 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 AMD19238.1 - 0.0081 16.2 3.9 0.013 15.5 1.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 AMD19238.1 - 0.011 15.4 9.8 0.011 15.4 9.8 2.9 3 0 0 3 3 3 0 RING-like zinc finger WG_beta_rep PF14903.6 AMD19239.1 - 0.087 13.1 0.3 0.85 10.0 0.1 2.4 2 0 0 2 2 2 0 WG containing repeat Ins_P5_2-kin PF06090.12 AMD19240.1 - 1.4e-12 47.7 0.1 2.1e-11 43.9 0.1 2.1 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DS PF01916.17 AMD19241.1 - 1.2e-128 428.4 0.2 1.4e-128 428.2 0.2 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Methyltransf_23 PF13489.6 AMD19242.1 - 1.3e-20 73.9 0.0 2e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD19242.1 - 7.1e-13 49.1 0.0 2.1e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD19242.1 - 7.8e-13 49.0 0.0 2.1e-12 47.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD19242.1 - 3.2e-12 46.5 0.0 7.5e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD19242.1 - 9.4e-11 42.2 0.0 3.2e-10 40.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AMD19242.1 - 1.9e-09 37.2 0.1 3.8e-09 36.2 0.1 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Bap31_Bap29_C PF18035.1 AMD19242.1 - 3.9 7.5 9.8 1.1 9.4 3.6 2.7 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain ECR1_N PF14382.6 AMD19243.1 - 1.2e-17 63.4 0.1 3e-17 62.1 0.1 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 AMD19243.1 - 2e-10 40.8 0.2 3.7e-10 40.0 0.2 1.5 1 0 0 1 1 1 1 KH domain Mu-transpos_C PF09299.11 AMD19243.1 - 0.022 14.7 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Mu transposase, C-terminal Met_10 PF02475.16 AMD19244.1 - 1.3e-66 224.2 0.0 1.9e-66 223.6 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 AMD19244.1 - 0.00037 19.8 1.8 0.0042 16.3 0.0 3.0 3 1 1 4 4 4 1 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.15 AMD19244.1 - 0.001 18.8 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Tenui_N PF05733.11 AMD19244.1 - 0.13 11.7 0.3 0.21 11.1 0.3 1.2 1 0 0 1 1 1 0 Tenuivirus/Phlebovirus nucleocapsid protein Cyclin_N PF00134.23 AMD19245.1 - 3.7e-07 29.9 1.6 5.2e-07 29.5 1.6 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AMD19245.1 - 0.0001 22.7 0.3 0.00013 22.4 0.3 1.2 1 0 0 1 1 1 1 Cyclin Sugar_tr PF00083.24 AMD19246.1 - 1.9e-165 551.1 28.4 2.2e-165 550.9 28.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD19246.1 - 5.5e-32 111.1 42.6 1.5e-26 93.2 18.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA-synt_1d PF00750.19 AMD19247.1 - 5.8e-121 403.7 9.0 7.7e-121 403.3 9.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 AMD19247.1 - 1.9e-29 102.2 0.3 8.7e-29 100.1 0.0 2.2 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 AMD19247.1 - 4.7e-07 30.3 0.0 1.7e-06 28.5 0.0 2.1 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain HTH_25 PF13413.6 AMD19247.1 - 0.16 11.8 0.8 8.4 6.3 0.0 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain DUF4393 PF14337.6 AMD19247.1 - 0.33 10.7 2.5 0.49 10.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4393) Sugar_tr PF00083.24 AMD19248.1 - 1.1e-164 548.6 26.6 1.3e-164 548.4 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD19248.1 - 1.3e-31 109.8 28.6 4.1e-26 91.8 19.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MSP1b PF03429.13 AMD19248.1 - 0.084 11.0 0.3 0.13 10.4 0.3 1.1 1 0 0 1 1 1 0 Major surface protein 1B Ni_hydr_CYTB PF01292.20 AMD19248.1 - 2 8.0 12.8 4.7 6.8 4.8 3.7 2 2 2 4 4 4 0 Prokaryotic cytochrome b561 DUF4293 PF14126.6 AMD19248.1 - 4 7.7 8.0 2.3 8.5 1.7 2.9 2 2 0 2 2 2 0 Domain of unknown function (DUF4293) Sugar_tr PF00083.24 AMD19249.1 - 4.7e-159 530.1 24.2 5.4e-159 529.9 24.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD19249.1 - 2.5e-31 108.9 30.4 8.9e-22 77.5 12.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 AMD19249.1 - 0.00025 19.6 2.1 0.00025 19.6 2.1 2.3 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Svf1 PF08622.10 AMD19250.1 - 8e-60 201.6 0.1 1.3e-59 200.9 0.1 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Svf1_C PF17187.4 AMD19250.1 - 3.9e-54 182.9 1.0 7.1e-53 178.8 0.3 2.2 2 0 0 2 2 2 2 Svf1-like C-terminal lipocalin-like domain Sod_Fe_C PF02777.18 AMD19251.1 - 5.9e-13 48.9 0.1 2.5e-10 40.5 0.1 2.4 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Pal1 PF08316.11 AMD19252.1 - 1.4e-48 165.1 1.3 1.4e-48 165.1 1.3 3.1 3 1 0 4 4 4 1 Pal1 cell morphology protein Sec23_trunk PF04811.15 AMD19253.1 - 3.4e-54 184.0 0.1 6.2e-54 183.1 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 AMD19253.1 - 1.9e-15 56.5 0.3 4e-15 55.5 0.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 AMD19253.1 - 2e-13 50.9 0.1 5e-13 49.6 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 AMD19253.1 - 1.3e-10 41.1 3.7 3.3e-10 39.9 3.7 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AMD19253.1 - 2.2e-05 24.3 0.2 0.00012 21.9 0.0 2.2 2 0 0 2 2 2 1 Gelsolin repeat VWA_2 PF13519.6 AMD19253.1 - 0.13 12.9 0.0 0.63 10.7 0.0 2.2 2 0 0 2 2 2 0 von Willebrand factor type A domain LIM PF00412.22 AMD19253.1 - 0.2 11.9 1.7 0.54 10.5 1.7 1.8 1 0 0 1 1 1 0 LIM domain Asp PF00026.23 AMD19254.1 - 6.2e-32 111.3 0.2 1e-31 110.6 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD19254.1 - 0.00099 19.4 2.0 0.021 15.1 0.3 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal CbiJ PF02571.14 AMD19254.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Precorrin-6x reductase CbiJ/CobK AA_permease PF00324.21 AMD19255.1 - 7.6e-131 437.0 32.1 9.1e-131 436.7 32.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD19255.1 - 7.6e-34 117.3 33.5 9.3e-34 117.0 33.5 1.1 1 0 0 1 1 1 1 Amino acid permease Copper-fist PF00649.18 AMD19255.1 - 0.045 13.2 0.6 0.12 11.9 0.6 1.7 1 1 0 1 1 1 0 Copper fist DNA binding domain EIF_2_alpha PF07541.12 AMD19256.1 - 9.9e-40 135.3 0.8 1.7e-39 134.5 0.4 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 AMD19256.1 - 1e-15 57.8 2.0 1e-15 57.8 2.0 1.6 2 0 0 2 2 2 1 S1 RNA binding domain SLIDE PF09111.10 AMD19256.1 - 0.022 14.8 1.2 0.061 13.4 0.0 2.3 3 0 0 3 3 3 0 SLIDE Memo PF01875.17 AMD19257.1 - 1.6e-87 293.1 0.0 2.1e-87 292.7 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein ATP-sulfurylase PF01747.17 AMD19258.1 - 5.7e-87 290.6 0.0 7.7e-87 290.2 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 AMD19258.1 - 1.2e-52 177.8 0.0 1.8e-52 177.2 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain CTP_transf_like PF01467.26 AMD19258.1 - 0.017 15.3 0.0 0.07 13.3 0.0 2.0 2 1 1 3 3 3 0 Cytidylyltransferase-like Biotin_lipoyl PF00364.22 AMD19259.1 - 4.4e-19 68.1 0.8 1.1e-18 66.8 0.8 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 AMD19259.1 - 4.2e-06 27.0 0.0 1e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain FGGY_N PF00370.21 AMD19260.1 - 7.6e-21 74.8 0.0 3.2e-13 49.8 0.0 2.5 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 AMD19260.1 - 1.4e-14 54.3 0.0 2.8e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Glycoprotein_B PF00606.18 AMD19260.1 - 0.087 12.3 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B ectodomain SPC12 PF06645.13 AMD19261.1 - 3.7e-24 84.6 0.8 4.2e-24 84.4 0.8 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF4600 PF15372.6 AMD19262.1 - 0.036 14.5 1.2 0.3 11.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) Candida_ALS_N PF11766.8 AMD19263.1 - 2.2e-51 174.5 1.3 2.9e-51 174.2 1.3 1.1 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding Big_8 PF17961.1 AMD19263.1 - 0.021 15.0 0.0 0.054 13.6 0.0 1.7 1 0 0 1 1 1 0 Bacterial Ig domain WHIM1 PF15612.6 AMD19264.1 - 0.00042 19.8 0.0 0.0024 17.4 0.0 2.4 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 PI-PLC-X PF00388.19 AMD19265.1 - 9.4e-19 67.4 0.0 2.4e-18 66.1 0.0 1.6 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain Ribosomal_L18A PF01775.17 AMD19265.1 - 0.012 15.8 0.2 0.021 14.9 0.2 1.4 1 0 0 1 1 1 0 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A ThuA PF06283.11 AMD19265.1 - 0.017 15.4 0.0 0.079 13.2 0.0 1.9 2 0 0 2 2 2 0 Trehalose utilisation Sld5 PF05916.11 AMD19266.1 - 5.6e-19 68.6 0.1 1e-18 67.8 0.1 1.4 1 0 0 1 1 1 1 GINS complex protein NAT PF04768.13 AMD19267.1 - 2.9e-46 157.2 0.1 6.8e-46 156.0 0.0 1.7 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase A_deaminase PF00962.22 AMD19268.1 - 2.9e-17 63.0 0.0 1.4e-07 31.2 0.0 2.9 2 1 0 2 2 2 2 Adenosine/AMP deaminase Myb_DNA-binding PF00249.31 AMD19269.1 - 7.8e-24 83.6 4.7 2.2e-14 53.3 0.2 2.5 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD19269.1 - 6.2e-20 71.2 2.4 5.3e-15 55.4 0.1 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 AMD19269.1 - 0.0025 17.8 0.0 0.0093 16.0 0.0 1.9 2 0 0 2 2 2 1 SLIDE Myb_DNA-bind_7 PF15963.5 AMD19269.1 - 0.1 12.5 0.0 2.9 7.8 0.0 2.3 1 1 1 2 2 2 0 Myb DNA-binding like Tim54 PF11711.8 AMD19270.1 - 2.4e-113 378.7 0.2 2e-77 260.5 0.2 2.0 1 1 1 2 2 2 2 Inner membrane protein import complex subunit Tim54 DUF5353 PF17304.2 AMD19270.1 - 0.2 11.4 0.8 21 4.9 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5353) Vps26 PF03643.15 AMD19271.1 - 6.1e-113 376.4 1.6 7.1e-113 376.2 1.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 AMD19271.1 - 1.6e-06 28.2 0.5 0.00046 20.3 0.3 3.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 AMD19271.1 - 0.025 15.0 0.3 0.23 11.9 0.2 2.3 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 AMD19271.1 - 0.033 13.4 1.2 8.3 5.5 0.0 2.8 2 1 0 3 3 3 0 Rgp1 DUF1947 PF09183.10 AMD19271.1 - 0.14 12.5 1.2 0.63 10.4 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1947) Pkinase PF00069.25 AMD19272.1 - 1.1e-38 133.2 0.0 1.5e-38 132.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19272.1 - 1.1e-20 74.0 0.0 1.4e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 AMD19272.1 - 5.9e-06 26.0 0.2 9e-06 25.4 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 AMD19272.1 - 0.00016 21.1 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD19272.1 - 0.0007 19.6 0.1 0.0018 18.2 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AMD19272.1 - 0.001 17.9 0.0 0.0015 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Tho1_MOS11_C PF18592.1 AMD19272.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Tho1/MOS11 C-terminal domain rRNA_proc-arch PF13234.6 AMD19274.1 - 5.7e-80 269.1 1.1 5.7e-80 269.1 1.1 1.8 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 AMD19274.1 - 6.2e-55 185.3 0.3 6.2e-55 185.3 0.3 1.9 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 AMD19274.1 - 1.3e-18 67.3 0.1 1.3e-17 64.1 0.0 2.7 3 1 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19274.1 - 3e-06 27.5 0.0 3.1e-05 24.3 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD19274.1 - 0.00075 19.5 0.7 0.012 15.6 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AMD19274.1 - 0.045 14.0 0.0 0.17 12.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain HSM3_N PF18795.1 AMD19275.1 - 2e-63 214.0 14.8 2e-63 214.0 14.8 1.5 2 0 0 2 2 2 1 DNA mismatch repair protein HSM3, N terminal domain HSM3_C PF18794.1 AMD19275.1 - 6.5e-54 182.2 4.0 1.7e-53 180.8 4.0 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, C terminal domain Snf7 PF03357.21 AMD19276.1 - 1.2e-15 57.6 16.4 1.9e-15 56.9 16.4 1.3 1 0 0 1 1 1 1 Snf7 DUF3450 PF11932.8 AMD19276.1 - 0.037 13.3 8.3 2.4 7.4 6.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Prefoldin_2 PF01920.20 AMD19276.1 - 0.12 12.4 13.6 6.4 6.8 10.1 3.0 2 1 0 2 2 2 0 Prefoldin subunit APG6_N PF17675.1 AMD19276.1 - 0.58 10.7 14.4 4 8.0 9.1 2.6 2 0 0 2 2 2 0 Apg6 coiled-coil region DivIC PF04977.15 AMD19276.1 - 1.4 8.7 15.3 0.65 9.8 0.3 3.5 2 1 1 3 3 3 0 Septum formation initiator Syntaxin_2 PF14523.6 AMD19276.1 - 2.8 8.4 15.9 3.8 7.9 5.5 3.3 1 1 0 2 2 2 0 Syntaxin-like protein SlyX PF04102.12 AMD19276.1 - 7.4 7.3 7.8 32 5.2 2.3 3.2 3 0 0 3 3 3 0 SlyX UBX PF00789.20 AMD19277.1 - 2.1e-18 66.3 0.0 4.2e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 UBX domain Pkinase PF00069.25 AMD19278.1 - 7.9e-59 199.2 0.0 1e-58 198.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19278.1 - 2.7e-34 118.6 0.0 4.2e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19278.1 - 1.8e-07 30.8 0.0 2.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AMD19278.1 - 7.2e-05 21.7 0.0 0.00011 21.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AMD19278.1 - 0.018 14.4 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD19278.1 - 0.14 12.0 0.1 0.31 10.9 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 AMD19278.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Rif1_N PF12231.8 AMD19279.1 - 1e-38 133.3 10.0 3.9e-38 131.4 10.0 2.1 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Ras PF00071.22 AMD19280.1 - 1.9e-39 134.8 0.3 9.8e-39 132.5 0.3 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 AMD19280.1 - 1.9e-32 112.0 0.5 2.6e-32 111.6 0.5 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD19280.1 - 2.7e-14 53.0 0.8 2.4e-13 49.9 0.8 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD19280.1 - 4.4e-07 30.0 0.1 6.2e-07 29.5 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AMD19280.1 - 1.3e-06 27.9 0.0 1.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AMD19280.1 - 0.00045 19.7 0.0 0.00085 18.8 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AMD19280.1 - 0.001 19.0 0.8 0.24 11.3 0.2 2.3 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 AMD19280.1 - 0.011 15.3 0.1 0.053 13.0 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain G-alpha PF00503.20 AMD19280.1 - 0.016 14.4 1.0 0.45 9.6 0.3 2.1 1 1 1 2 2 2 0 G-protein alpha subunit AAA_16 PF13191.6 AMD19280.1 - 0.025 15.0 0.0 0.047 14.1 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 AMD19280.1 - 0.035 13.4 0.1 0.055 12.7 0.1 1.2 1 0 0 1 1 1 0 Septin DUF503 PF04456.12 AMD19280.1 - 0.039 13.8 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF503) MMR_HSR1_Xtn PF16897.5 AMD19280.1 - 0.039 14.0 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TniB PF05621.11 AMD19280.1 - 0.048 13.1 0.0 0.085 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein SHMT PF00464.19 AMD19281.1 - 1e-202 673.0 0.0 1.5e-202 672.5 0.0 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 AMD19281.1 - 0.00082 18.6 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II zf-H2C2_2 PF13465.6 AMD19282.1 - 3.9e-29 99.7 36.3 2.5e-09 37.1 0.6 6.4 6 0 0 6 6 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 AMD19282.1 - 5.7e-24 83.2 50.8 1.3e-06 28.5 2.3 9.0 8 0 0 8 8 8 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD19282.1 - 5.6e-12 45.4 78.2 0.00016 22.2 1.5 9.6 10 0 0 10 10 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AMD19282.1 - 1e-08 35.2 38.4 0.0005 20.3 1.0 7.9 8 0 0 8 8 7 3 Zinc-finger double-stranded RNA-binding Zap1_zf2 PF18217.1 AMD19282.1 - 3.1e-08 33.4 2.1 3.1e-08 33.4 2.1 4.1 6 0 0 6 6 4 1 Zap1 zinc finger 2 zf-C2H2_8 PF15909.5 AMD19282.1 - 3.2e-08 33.8 18.6 3.1e-06 27.4 3.2 4.5 2 1 2 4 4 4 2 C2H2-type zinc ribbon zf-met PF12874.7 AMD19282.1 - 1.4e-07 31.6 33.4 0.055 13.9 0.8 7.2 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AMD19282.1 - 2e-05 24.4 40.1 0.0096 15.9 0.7 7.5 6 1 1 7 7 7 3 C2H2-type zinc finger zf-C2HC_2 PF13913.6 AMD19282.1 - 0.0026 17.6 21.6 0.51 10.3 0.2 5.8 6 0 0 6 6 6 2 zinc-finger of a C2HC-type FOXP-CC PF16159.5 AMD19282.1 - 0.005 17.4 1.4 0.11 13.1 0.1 7.4 5 2 3 8 8 7 4 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 AMD19282.1 - 0.023 14.5 1.0 0.023 14.5 1.0 6.5 8 0 0 8 8 7 0 zinc-finger C2H2-type NAD_binding_6 PF08030.12 AMD19282.1 - 0.026 14.6 2.1 0.5 10.5 0.2 2.8 2 1 0 2 2 2 0 Ferric reductase NAD binding domain zf-BED PF02892.15 AMD19282.1 - 0.23 11.5 20.6 0.74 9.9 1.8 4.3 1 1 3 4 4 4 0 BED zinc finger zf-CHCC PF10276.9 AMD19282.1 - 0.44 10.7 6.0 3.6 7.7 0.5 3.4 3 0 0 3 3 3 0 Zinc-finger domain zf-C2H2_9 PF16293.5 AMD19282.1 - 0.46 10.4 17.1 0.58 10.0 0.1 5.4 5 1 1 6 6 6 0 C2H2 type zinc-finger (1 copy) DUF3268 PF11672.8 AMD19282.1 - 1.7 9.0 12.1 2.5 8.4 6.1 2.8 2 0 0 2 2 2 0 zinc-finger-containing domain Pkinase PF00069.25 AMD19283.1 - 5.7e-31 107.8 0.0 2.5e-30 105.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19283.1 - 3e-19 69.3 0.0 2.5e-18 66.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 AMD19283.1 - 0.021 14.5 0.1 1.5 8.4 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AMD19283.1 - 0.03 13.1 0.0 0.052 12.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase zf-ribbon_3 PF13248.6 AMD19283.1 - 0.14 11.6 0.2 0.29 10.6 0.2 1.6 1 0 0 1 1 1 0 zinc-ribbon domain HbrB PF08539.11 AMD19284.1 - 3.9e-27 95.3 0.1 2.5e-26 92.7 0.1 2.2 1 1 0 1 1 1 1 HbrB-like DARPP-32 PF05395.12 AMD19284.1 - 0.019 15.2 0.2 0.039 14.2 0.2 1.5 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 CLN3 PF02487.17 AMD19285.1 - 1.3e-136 455.8 13.3 1.6e-136 455.5 13.3 1.0 1 0 0 1 1 1 1 CLN3 protein Aminotran_1_2 PF00155.21 AMD19286.1 - 5.9e-71 239.6 0.0 6.8e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AMD19286.1 - 0.056 12.0 0.1 0.11 11.0 0.1 1.5 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF1674 PF07896.12 AMD19287.1 - 4.2e-18 65.6 1.5 1.1e-17 64.2 1.5 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Nup88 PF10168.9 AMD19288.1 - 0.00076 17.4 0.0 0.00076 17.4 0.0 2.3 2 0 0 2 2 2 1 Nuclear pore component Nup54 PF13874.6 AMD19288.1 - 0.2 11.8 2.6 0.5 10.5 2.6 1.7 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Ribosomal_L37 PF08561.10 AMD19289.1 - 1.5e-21 77.1 5.5 4.7e-16 59.4 0.1 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 Phosphodiest PF01663.22 AMD19290.1 - 8.2e-14 51.9 1.3 3e-09 36.9 0.2 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 AMD19290.1 - 5.4e-05 22.7 0.0 9.6e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 AMD19290.1 - 0.049 13.0 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Sulfatase zf-C2H2_2 PF12756.7 AMD19291.1 - 6.3e-34 116.3 12.3 9.6e-34 115.7 1.2 3.2 4 0 0 4 4 4 2 C2H2 type zinc-finger (2 copies) End3 PF12761.7 AMD19291.1 - 0.014 15.6 7.8 0.014 15.6 7.8 1.7 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 zf-C2H2_jaz PF12171.8 AMD19291.1 - 0.27 11.6 1.8 0.76 10.1 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding adh_short PF00106.25 AMD19292.1 - 1.5e-19 70.2 0.0 2.7e-19 69.4 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AMD19292.1 - 7.7e-17 61.8 0.1 1e-16 61.4 0.1 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 AMD19292.1 - 2.9e-07 30.3 0.0 4.7e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 AMD19292.1 - 0.0078 15.4 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 AMD19292.1 - 0.0086 15.6 0.2 0.038 13.4 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 AMD19292.1 - 0.082 13.5 0.0 0.18 12.4 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Cyt_b-c1_8 PF10890.8 AMD19293.1 - 0.045 14.2 0.0 0.081 13.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 WRNPLPNID PF15017.6 AMD19293.1 - 0.091 13.7 0.2 0.13 13.2 0.2 1.3 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Mrpl_C PF18502.1 AMD19294.1 - 2.2e-28 98.8 0.2 4.8e-28 97.6 0.2 1.6 1 0 0 1 1 1 1 54S ribosomal protein L8 C-terminal domain Ribosomal_L17 PF01196.19 AMD19294.1 - 3.8e-27 95.0 1.6 3.5e-25 88.7 0.1 2.2 2 0 0 2 2 2 2 Ribosomal protein L17 HTH_39 PF14090.6 AMD19294.1 - 0.034 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain EF-G-binding_N PF07299.11 AMD19294.1 - 0.22 12.0 2.4 0.49 10.9 0.3 2.4 3 0 0 3 3 3 0 Elongation factor G-binding protein, N-terminal PALP PF00291.25 AMD19295.1 - 1.5e-62 211.7 0.0 1.7e-62 211.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DSPc PF00782.20 AMD19296.1 - 2.8e-27 95.1 0.1 8.7e-22 77.4 0.2 3.4 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AMD19296.1 - 5.7e-07 29.3 0.1 2.1e-05 24.2 0.1 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 AMD19296.1 - 0.0014 18.3 0.5 0.03 14.0 0.0 2.6 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 AMD19296.1 - 0.064 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF1764 PF08576.10 AMD19296.1 - 0.096 13.6 0.2 0.21 12.5 0.2 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Init_tRNA_PT PF04179.12 AMD19296.1 - 0.14 12.5 0.1 0.36 11.1 0.1 1.6 1 0 0 1 1 1 0 Rit1 DUSP-like domain CBFD_NFYB_HMF PF00808.23 AMD19297.1 - 0.00011 22.4 0.3 0.00011 22.4 0.3 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone BUD22 PF09073.10 AMD19297.1 - 0.0043 16.5 4.9 0.0047 16.3 4.9 1.0 1 0 0 1 1 1 1 BUD22 MPM1 PF17234.2 AMD19298.1 - 4.8e-54 183.2 1.8 6.9e-54 182.7 1.8 1.2 1 0 0 1 1 1 1 Mitochondrial peculiar membrane protein 1 Paf1 PF03985.13 AMD19299.1 - 2.1e-96 323.5 14.4 2.4e-96 323.4 14.4 1.0 1 0 0 1 1 1 1 Paf1 Chibby PF14645.6 AMD19299.1 - 0.079 13.4 0.9 0.27 11.7 0.2 2.2 2 0 0 2 2 2 0 Chibby family DUF445 PF04286.12 AMD19299.1 - 0.12 12.2 3.5 0.21 11.4 1.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF445) RapH_N PF18801.1 AMD19299.1 - 3.1 8.0 7.1 0.29 11.2 1.6 2.3 3 0 0 3 3 3 0 response regulator aspartate phosphatase H, N terminal DUF2951 PF11166.8 AMD19299.1 - 4 7.7 8.4 1.5 9.1 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2951) Esterase PF00756.20 AMD19300.1 - 1.8e-57 194.9 0.1 2.1e-57 194.7 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 AMD19300.1 - 0.0027 17.2 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 AMD19300.1 - 0.18 11.3 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase RCC1_2 PF13540.6 AMD19301.1 - 1.7e-17 62.7 10.2 8.9e-09 34.9 0.1 5.0 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 AMD19301.1 - 4.8e-13 49.5 1.9 0.00021 21.9 0.1 6.1 5 1 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 AMD19301.1 - 0.00027 20.8 0.0 0.0005 19.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like MTS PF05175.14 AMD19301.1 - 0.00053 19.6 0.0 0.039 13.5 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase small domain Peptidase_M20 PF01546.28 AMD19302.1 - 3.6e-24 85.6 0.0 6.6e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AMD19302.1 - 5.5e-11 42.3 0.0 9.4e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.32 AMD19302.1 - 5.9e-07 30.1 9.8 0.11 13.4 0.1 6.7 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19302.1 - 0.024 14.9 0.0 11 6.4 0.0 3.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD19303.1 - 2.3e-11 44.1 0.9 0.0019 19.0 0.0 5.0 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19303.1 - 3.2e-08 33.8 0.0 0.68 10.3 0.0 4.5 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 AMD19303.1 - 0.19 11.1 16.8 0.34 10.3 16.8 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 AMD19303.1 - 0.53 8.4 16.4 0.74 8.0 16.4 1.1 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 AMD19303.1 - 4.1 6.7 10.7 7.1 5.9 10.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MRP-L27 PF09809.9 AMD19304.1 - 7.7e-31 106.3 0.5 1.2e-30 105.6 0.5 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Cullin_Nedd8 PF10557.9 AMD19305.1 - 0.075 13.1 0.1 0.51 10.4 0.0 2.4 3 0 0 3 3 3 0 Cullin protein neddylation domain RhoGAP PF00620.27 AMD19306.1 - 4.5e-40 136.9 0.0 9.7e-40 135.9 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 AMD19306.1 - 0.00032 20.9 0.2 0.0011 19.2 0.2 2.0 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DNA_repr_REX1B PF14966.6 AMD19306.1 - 0.061 14.0 0.4 0.19 12.4 0.4 1.9 1 0 0 1 1 1 0 DNA repair REX1-B CHIPS PF11434.8 AMD19306.1 - 0.17 11.8 1.5 0.55 10.1 0.1 2.6 3 0 0 3 3 3 0 Chemotaxis-inhibiting protein CHIPS Methyltransf_PK PF05891.12 AMD19307.1 - 7.1e-89 297.0 0.0 8.1e-89 296.9 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 AMD19307.1 - 7.7e-09 36.1 0.0 5.3e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD19307.1 - 0.00019 21.3 0.0 0.00033 20.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD19307.1 - 0.00045 20.8 0.0 0.00093 19.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 AMD19307.1 - 0.0042 16.4 0.0 0.011 15.0 0.0 1.6 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 AMD19307.1 - 0.069 13.9 0.0 0.19 12.5 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain AIM5 PF17050.5 AMD19308.1 - 2e-06 28.5 0.6 2.8e-06 28.0 0.6 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 SecY PF00344.20 AMD19309.1 - 1e-37 130.1 16.5 1.4e-37 129.6 16.5 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AMD19309.1 - 7.7e-09 35.2 0.0 3.4e-08 33.2 0.0 2.3 1 0 0 1 1 1 1 Plug domain of Sec61p COMPASS-Shg1 PF05205.12 AMD19311.1 - 3.6e-19 69.3 4.5 4.6e-19 69.0 4.5 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 UPF0086 PF01868.16 AMD19312.1 - 4.5e-22 77.8 0.0 9.9e-22 76.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function UPF0086 BPL_LplA_LipB PF03099.19 AMD19313.1 - 1.3e-05 25.1 0.0 4.4e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Flocculin_t3 PF13928.6 AMD19315.1 - 2e-11 44.2 35.1 2.8e-07 30.9 17.7 6.4 6 1 0 6 6 6 2 Flocculin type 3 repeat DUF3179 PF11376.8 AMD19315.1 - 2.3 7.5 7.5 3.2 7.1 1.0 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3179) EI24 PF07264.11 AMD19316.1 - 0.00063 20.0 18.8 0.0017 18.6 18.6 1.8 1 1 1 2 2 2 1 Etoposide-induced protein 2.4 (EI24) CDC45 PF02724.14 AMD19316.1 - 0.1 10.8 8.1 0.12 10.6 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein FYDLN_acid PF09538.10 AMD19316.1 - 0.14 12.8 13.9 0.24 12.1 13.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Peptidase_M28 PF04389.17 AMD19317.1 - 2.4e-38 131.8 0.1 5e-38 130.8 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 AMD19317.1 - 3.6e-09 36.5 0.0 8.2e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M42 PF05343.14 AMD19317.1 - 0.00024 20.2 0.0 0.00054 19.1 0.0 1.5 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.28 AMD19317.1 - 0.00048 19.9 0.0 0.00098 18.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Mistic PF11458.8 AMD19317.1 - 0.0055 16.6 0.1 0.56 10.2 0.0 3.2 2 1 1 3 3 3 1 Membrane-integrating protein Mistic DnaJ PF00226.31 AMD19318.1 - 7.8e-19 67.6 6.1 7.8e-19 67.6 6.1 2.7 4 0 0 4 4 4 1 DnaJ domain TFIIA PF03153.13 AMD19318.1 - 0.01 15.9 10.7 0.016 15.2 10.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF356 PF04009.12 AMD19318.1 - 0.25 11.7 1.5 1.8 8.9 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF356) Spt20 PF12090.8 AMD19318.1 - 0.33 10.5 19.5 0.57 9.8 19.5 1.3 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 AMD19318.1 - 0.46 11.5 7.8 1.3 10.0 7.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4407 PF14362.6 AMD19318.1 - 1.5 8.1 8.3 2.6 7.3 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) baeRF_family5 PF18846.1 AMD19318.1 - 4.3 7.5 9.1 4.2 7.6 5.2 2.4 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 Hydrolase_3 PF08282.12 AMD19318.1 - 7.7 6.2 10.3 5.4 6.7 7.3 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Mem_trans PF03547.18 AMD19319.1 - 2.6e-59 200.6 10.1 2.8e-58 197.2 10.1 1.9 1 1 0 1 1 1 1 Membrane transport protein B12D PF06522.11 AMD19319.1 - 4.8 7.1 7.3 0.51 10.2 0.2 2.8 3 0 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit SMC_N PF02463.19 AMD19320.1 - 5.8e-52 176.3 48.2 2.3e-51 174.3 48.2 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AMD19320.1 - 1.9e-27 95.9 0.2 9.4e-27 93.6 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AMD19320.1 - 5.9e-16 59.1 6.5 1.4e-09 38.2 0.1 3.4 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AMD19320.1 - 8.3e-15 55.8 7.6 8.3e-15 55.8 7.6 7.8 3 3 4 7 7 7 1 AAA domain AAA_15 PF13175.6 AMD19320.1 - 2.8e-08 33.9 28.8 2.8e-08 33.9 28.8 4.5 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 AMD19320.1 - 0.079 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RyR PF02026.16 AMD19320.1 - 0.12 12.5 3.0 0.23 11.6 0.4 3.0 2 0 0 2 2 2 0 RyR domain FerA PF08165.11 AMD19320.1 - 0.17 11.8 8.9 0.92 9.5 0.8 4.2 3 0 0 3 3 3 0 FerA (NUC095) domain Cytokin_check_N PF10407.9 AMD19321.1 - 3e-31 107.2 3.3 8.2e-31 105.8 2.9 2.1 2 0 0 2 2 2 1 Cdc14 phosphatase binding protein N-terminus CAP PF00188.26 AMD19323.1 - 4.7e-17 63.0 0.1 7.8e-17 62.3 0.1 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Ndc1_Nup PF09531.10 AMD19323.1 - 3.1 6.4 6.5 3.9 6.0 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CAP PF00188.26 AMD19324.1 - 1.6e-20 74.2 3.6 2.4e-20 73.7 3.6 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family KH_1 PF00013.29 AMD19325.1 - 6.5e-72 237.3 25.4 1.3e-11 44.2 0.1 11.7 12 0 0 12 12 12 9 KH domain KH_2 PF07650.17 AMD19325.1 - 8.4e-06 25.5 12.1 0.0032 17.3 0.4 4.7 5 0 0 5 5 5 2 KH domain KH_4 PF13083.6 AMD19325.1 - 2.7e-05 24.0 0.2 0.92 9.4 0.0 4.7 4 0 0 4 4 4 2 KH domain KH_5 PF13184.6 AMD19325.1 - 0.02 14.9 3.8 10 6.3 0.1 4.7 4 0 0 4 4 4 0 NusA-like KH domain BMC PF00936.19 AMD19325.1 - 0.022 14.7 3.2 5.5 7.1 0.1 4.7 4 1 1 5 5 5 0 BMC domain Skp1 PF01466.19 AMD19325.1 - 0.078 13.1 0.2 14 5.9 0.0 2.8 2 0 0 2 2 2 0 Skp1 family, dimerisation domain DUF2067 PF09840.9 AMD19325.1 - 0.17 11.5 13.3 2.9 7.4 0.4 5.3 4 1 1 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2067) Arch_flagellin PF01917.16 AMD19325.1 - 0.19 11.9 4.8 0.22 11.7 2.4 2.3 2 0 0 2 2 2 0 Archaebacterial flagellin SLS PF14611.6 AMD19325.1 - 0.99 9.2 10.3 0.67 9.8 0.1 4.6 4 2 1 6 6 6 0 Mitochondrial inner-membrane-bound regulator YbbR PF07949.12 AMD19325.1 - 7.2 7.0 18.7 0.39 11.1 0.1 6.1 6 1 1 7 7 7 0 YbbR-like protein Ras PF00071.22 AMD19326.1 - 1.5e-53 180.7 0.2 1.8e-53 180.5 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD19326.1 - 7.8e-36 122.9 0.1 1.2e-35 122.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD19326.1 - 7.6e-14 51.5 0.1 1e-13 51.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD19326.1 - 1.2e-05 25.4 0.0 2.6e-05 24.3 0.0 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AMD19326.1 - 6.2e-05 22.5 0.1 8.9e-05 21.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AMD19326.1 - 0.0037 16.8 0.1 0.0071 15.9 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AMD19326.1 - 0.021 14.7 0.4 0.87 9.5 0.1 2.4 1 1 0 2 2 2 0 RsgA GTPase TniB PF05621.11 AMD19326.1 - 0.023 14.1 0.0 0.046 13.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 AMD19326.1 - 0.094 13.1 0.0 0.17 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Dicer_N PF17895.1 AMD19326.1 - 0.18 11.7 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Giardia Dicer N-terminal domain Mitofilin PF09731.9 AMD19327.1 - 5.9e-40 137.7 17.1 2e-35 122.8 16.1 2.1 2 0 0 2 2 2 2 Mitochondrial inner membrane protein Prp18 PF02840.15 AMD19327.1 - 0.6 10.2 8.7 5.1 7.1 7.0 2.7 1 1 1 2 2 2 0 Prp18 domain Actin PF00022.19 AMD19328.1 - 5e-96 321.8 0.0 3.3e-95 319.1 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AMD19328.1 - 0.012 14.5 0.0 0.29 9.9 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein IBR PF01485.21 AMD19329.1 - 4e-17 62.2 40.8 1.8e-09 37.6 5.8 3.7 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 AMD19329.1 - 0.0014 18.5 10.6 0.0014 18.5 10.6 5.2 4 1 1 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-RING_14 PF17978.1 AMD19329.1 - 0.015 15.7 5.2 0.015 15.7 5.2 3.3 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 AMD19329.1 - 0.02 14.9 8.2 0.02 14.9 8.2 4.0 4 0 0 4 4 4 0 RING-type zinc-finger zf-RING_2 PF13639.6 AMD19329.1 - 0.1 12.9 41.5 0.044 14.1 9.9 4.0 3 1 0 3 3 3 0 Ring finger domain zf-C3HC4_4 PF15227.6 AMD19329.1 - 0.91 9.7 39.9 0.25 11.5 10.5 4.4 2 1 0 3 3 3 0 zinc finger of C3HC4-type, RING EF-hand_4 PF12763.7 AMD19330.1 - 2.7e-05 24.1 0.1 6.1e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 AMD19330.1 - 0.058 13.9 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair Vps51 PF08700.11 AMD19331.1 - 2.5e-13 49.9 6.8 4.4e-13 49.1 2.6 2.1 2 0 0 2 2 2 1 Vps51/Vps67 HBS1_N PF08938.10 AMD19331.1 - 0.076 13.3 2.8 0.11 12.8 2.2 1.6 1 1 0 1 1 1 0 HBS1 N-terminus Arrestin_C PF02752.22 AMD19332.1 - 2.1e-16 60.6 0.0 1.4e-13 51.5 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AMD19332.1 - 2.8e-06 27.5 0.0 0.00045 20.3 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain TMEM252 PF15664.5 AMD19332.1 - 0.036 13.8 0.4 0.08 12.7 0.4 1.5 1 0 0 1 1 1 0 Transmembrane protein 252 family Exo70 PF03081.15 AMD19333.1 - 1.8e-83 280.7 4.8 1.8e-83 280.7 4.8 1.6 2 0 0 2 2 2 1 Exo70 exocyst complex subunit DUF5344 PF17279.2 AMD19333.1 - 0.0085 16.6 2.3 1.9 9.1 0.1 4.4 3 1 1 4 4 4 1 Family of unknown function (DUF5344) phiKZ_IP PF12699.7 AMD19333.1 - 0.016 14.4 6.8 0.74 8.9 0.2 3.2 3 0 0 3 3 3 0 phiKZ-like phage internal head proteins DUF573 PF04504.14 AMD19333.1 - 0.036 14.7 1.6 0.57 10.9 0.6 3.2 1 1 1 2 2 2 0 Protein of unknown function, DUF573 DUF5341 PF17276.2 AMD19333.1 - 0.17 12.1 0.1 0.38 10.9 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5341) HMA PF00403.26 AMD19333.1 - 0.3 11.6 1.9 0.39 11.2 0.4 2.0 2 0 0 2 2 2 0 Heavy-metal-associated domain Fib_alpha PF08702.10 AMD19333.1 - 6 7.0 8.3 10 6.3 0.1 3.7 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family RNA_lig_T4_1 PF09511.10 AMD19334.1 - 5e-81 271.7 0.1 1.7e-80 270.0 0.1 2.0 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.11 AMD19334.1 - 1.3e-72 243.4 0.6 2.7e-72 242.3 0.2 1.8 2 0 0 2 2 2 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 AMD19334.1 - 1.6e-54 185.0 1.4 2.6e-54 184.4 1.4 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain PRK PF00485.18 AMD19334.1 - 0.0078 16.0 1.0 0.018 14.8 0.0 2.1 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family OTCace PF00185.24 AMD19335.1 - 1.4e-48 164.9 1.3 2.6e-48 164.0 1.3 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 AMD19335.1 - 1e-42 145.6 0.7 3.3e-42 144.0 0.3 1.9 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RFX5_N PF18326.1 AMD19335.1 - 0.15 11.9 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 RFX5 N-terminal domain NTR2 PF15458.6 AMD19336.1 - 4.4e-21 75.7 24.3 6e-21 75.3 24.3 1.2 1 0 0 1 1 1 1 Nineteen complex-related protein 2 Zn_clus PF00172.18 AMD19337.1 - 1.5e-10 41.1 11.5 2.5e-10 40.3 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MYO10_CC PF16735.5 AMD19337.1 - 0.059 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Unconventional myosin-X coiled coil domain BRCT PF00533.26 AMD19338.1 - 6.3e-15 55.3 0.7 0.0021 18.4 0.0 4.5 4 0 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 AMD19338.1 - 2.1e-10 40.9 0.1 0.00063 20.1 0.0 3.5 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 AMD19338.1 - 2.5e-08 33.8 1.3 0.00076 19.4 0.0 3.6 3 0 0 3 3 3 2 twin BRCT domain BRCT_3 PF18428.1 AMD19338.1 - 0.0032 17.5 0.0 0.011 15.8 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain GWT1 PF06423.12 AMD19339.1 - 5.7e-36 123.9 10.7 1.2e-35 122.9 7.1 2.6 2 1 0 2 2 2 1 GWT1 DUF4818 PF16089.5 AMD19339.1 - 0.072 13.6 0.1 0.072 13.6 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4818) UvrD-helicase PF00580.21 AMD19340.1 - 6.5e-61 206.6 0.0 6.5e-61 206.6 0.0 2.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 AMD19340.1 - 5.8e-45 154.2 2.2 1e-21 77.7 0.0 2.7 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 AMD19340.1 - 1.6e-29 103.2 0.0 4.6e-29 101.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 AMD19340.1 - 3.1e-09 36.5 0.4 0.00034 20.4 0.0 2.6 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 AMD19340.1 - 0.00019 21.2 0.0 0.015 15.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 AMD19340.1 - 0.0039 16.8 0.5 0.04 13.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain Helicase_RecD PF05127.14 AMD19340.1 - 0.037 13.9 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 Helicase Viral_helicase1 PF01443.18 AMD19340.1 - 0.042 13.6 1.3 15 5.2 0.0 3.9 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase Pkinase PF00069.25 AMD19341.1 - 5.8e-67 225.8 0.0 9.1e-67 225.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19341.1 - 1.2e-44 152.5 0.0 2.1e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19341.1 - 6.6e-09 35.5 0.0 4.8e-06 26.1 0.0 2.6 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AMD19341.1 - 0.018 13.8 0.0 0.046 12.5 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 AMD19341.1 - 0.032 14.2 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SAM_2 PF07647.17 AMD19341.1 - 0.036 14.2 0.3 0.078 13.1 0.3 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Kdo PF06293.14 AMD19341.1 - 0.08 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L21p PF00829.21 AMD19342.1 - 1.4e-10 41.4 0.0 1.7e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein PTPLA PF04387.14 AMD19343.1 - 3.2e-47 160.3 6.3 3.2e-47 160.3 6.3 1.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA SAPS PF04499.15 AMD19344.1 - 5.4e-183 609.2 0.0 5.4e-183 609.2 0.0 3.7 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein ChAPs PF09295.10 AMD19345.1 - 2.4e-48 165.1 0.8 1.9e-41 142.4 0.0 2.4 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 AMD19345.1 - 1.8e-05 25.1 0.1 0.21 12.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD19345.1 - 2.9e-05 23.8 0.4 0.07 13.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 AMD19345.1 - 3e-05 23.9 0.0 0.012 15.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 AMD19345.1 - 8.4e-05 22.2 0.6 0.055 13.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 AMD19345.1 - 0.00012 22.2 0.0 0.58 10.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD19345.1 - 0.00018 21.7 0.4 0.75 10.1 0.2 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 AMD19345.1 - 0.0002 21.1 0.3 0.3 11.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 AMD19345.1 - 0.00047 20.3 0.1 0.049 14.0 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 AMD19345.1 - 0.0071 16.8 0.7 1.2 9.7 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 AMD19345.1 - 0.0077 16.5 0.0 1.8 8.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat PI3_PI4_kinase PF00454.27 AMD19346.1 - 2.2e-55 188.2 0.0 3.4e-55 187.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase GCS PF03074.16 AMD19347.1 - 6.4e-144 479.8 0.2 8.4e-144 479.4 0.2 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 AMD19347.1 - 0.012 15.0 0.1 0.021 14.2 0.1 1.3 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) GTP_EFTU PF00009.27 AMD19348.1 - 3.3e-60 203.0 0.0 5.9e-60 202.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 AMD19348.1 - 2.9e-27 94.6 0.0 7e-27 93.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 AMD19348.1 - 3.9e-13 49.2 0.1 7.3e-07 29.1 0.0 2.6 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AMD19348.1 - 2e-07 31.3 0.5 6.2e-07 29.7 0.5 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 AMD19348.1 - 3.8e-06 26.8 0.0 7.7e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 AMD19348.1 - 0.036 14.1 0.1 0.099 12.7 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 AMD19348.1 - 0.13 11.6 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit IF-2B PF01008.17 AMD19349.1 - 2.5e-73 246.7 0.0 2.8e-73 246.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Sin_N PF04801.13 AMD19350.1 - 6.8e-24 84.9 1.0 1.7e-23 83.6 1.0 1.6 1 1 0 1 1 1 1 Sin-like protein conserved region DEAD PF00270.29 AMD19351.1 - 8.6e-41 139.6 0.0 1.3e-40 139.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19351.1 - 5.8e-18 65.3 0.0 2.2e-17 63.4 0.0 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AMD19351.1 - 7.8e-17 61.3 0.4 2.5e-16 59.7 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AMD19351.1 - 0.00013 22.1 0.0 0.00027 21.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zn_clus PF00172.18 AMD19352.1 - 6.1e-07 29.5 11.0 1.1e-06 28.6 11.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 AMD19352.1 - 0.0001 22.3 0.0 0.00022 21.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold zf-C2HC5 PF06221.13 AMD19353.1 - 2.7e-23 81.7 5.7 4.7e-23 80.9 5.7 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type EF-hand_5 PF13202.6 AMD19353.1 - 0.28 10.7 1.9 0.72 9.5 0.5 2.4 2 1 0 2 2 2 0 EF hand zf-CCCH PF00642.24 AMD19354.1 - 0.013 15.4 4.0 0.013 15.4 4.0 4.6 4 1 1 5 5 5 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Toxin_7 PF05980.12 AMD19354.1 - 8.6 6.7 9.2 0.17 12.2 1.9 2.0 2 0 0 2 2 2 0 Toxin 7 Pam16 PF03656.13 AMD19355.1 - 2.8e-44 150.2 0.7 3.1e-44 150.0 0.7 1.0 1 0 0 1 1 1 1 Pam16 PHD PF00628.29 AMD19356.1 - 6e-10 38.9 6.9 1.4e-09 37.7 6.9 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 AMD19356.1 - 0.00015 21.2 2.0 0.00029 20.3 2.0 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 AMD19356.1 - 0.023 15.1 23.6 0.09 13.2 14.6 3.7 2 2 0 2 2 2 0 SET domain CDC45 PF02724.14 AMD19356.1 - 0.17 10.1 16.0 0.42 8.8 16.0 1.7 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 AMD19357.1 - 2.4e-51 174.6 0.1 2.5e-49 168.0 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19357.1 - 1.5e-26 93.2 0.2 1e-25 90.5 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 AMD19357.1 - 0.0091 15.4 0.2 0.017 14.5 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ThrE PF06738.12 AMD19358.1 - 1.7e-69 233.9 17.4 2.8e-65 220.0 5.4 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 AMD19358.1 - 4.2e-13 49.6 9.0 4.2e-13 49.6 9.0 2.3 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE BP28CT PF08146.12 AMD19359.1 - 1.3e-34 119.3 3.9 1.3e-34 119.3 3.9 2.9 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 AMD19359.1 - 3.1e-15 56.6 0.6 3.1e-15 56.6 0.6 5.8 6 2 1 7 7 7 1 U3 small nucleolar RNA-associated protein 10 CLASP_N PF12348.8 AMD19359.1 - 9.2e-07 28.6 4.3 0.091 12.3 1.5 4.0 3 0 0 3 3 3 2 CLASP N terminal HEAT_2 PF13646.6 AMD19359.1 - 9.2e-05 22.8 0.2 1.8 9.0 0.0 4.1 4 0 0 4 4 4 2 HEAT repeats Katanin_con80 PF13925.6 AMD19359.1 - 0.00041 20.4 2.0 0.0029 17.7 0.0 3.5 3 0 0 3 3 3 1 con80 domain of Katanin HEAT PF02985.22 AMD19359.1 - 0.0074 16.5 5.3 0.37 11.2 0.0 5.1 5 0 0 5 5 5 1 HEAT repeat DUF1957 PF09210.11 AMD19359.1 - 0.015 15.7 0.1 0.056 13.9 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1957) DUF3385 PF11865.8 AMD19359.1 - 0.037 13.9 17.3 4.2 7.2 0.1 6.1 5 2 1 6 6 6 0 Domain of unknown function (DUF3385) Vac14_Fab1_bd PF12755.7 AMD19359.1 - 0.074 13.7 4.5 8 7.1 0.0 4.7 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region Vps39_2 PF10367.9 AMD19359.1 - 1.7 9.2 4.9 8.4 6.9 0.7 3.8 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 UNC-50 PF05216.13 AMD19360.1 - 2e-83 279.3 21.8 2.4e-83 279.1 21.8 1.0 1 0 0 1 1 1 1 UNC-50 family PLDc PF00614.22 AMD19361.1 - 5.6e-16 58.0 0.7 1.7e-07 31.1 0.3 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 AMD19361.1 - 2.9e-12 46.6 0.0 7e-07 29.2 0.0 3.5 2 0 0 2 2 2 2 PLD-like domain PX PF00787.24 AMD19361.1 - 8.6e-07 28.9 4.9 0.0012 18.9 0.5 3.7 3 0 0 3 3 3 2 PX domain DUF2118 PF09891.9 AMD19361.1 - 0.042 13.8 0.1 0.76 9.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) DOPA_dioxygen PF08883.11 AMD19362.1 - 7.8e-22 77.5 0.0 9.3e-22 77.2 0.0 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family GATA PF00320.27 AMD19363.1 - 6e-13 48.2 6.0 1e-12 47.4 6.0 1.4 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 AMD19363.1 - 0.041 13.4 0.7 0.077 12.5 0.7 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Auto_anti-p27 PF06677.12 AMD19363.1 - 0.081 13.1 2.6 0.14 12.3 2.6 1.3 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Snf7 PF03357.21 AMD19364.1 - 1.1e-11 44.7 16.5 1.5e-11 44.2 16.5 1.2 1 0 0 1 1 1 1 Snf7 BORCS7 PF16088.5 AMD19364.1 - 0.015 15.5 0.6 0.015 15.5 0.6 2.4 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 DMSP_lyase PF16867.5 AMD19364.1 - 0.17 11.5 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase FliG_N PF14842.6 AMD19364.1 - 0.29 11.7 5.8 0.53 10.9 0.4 2.3 1 1 1 2 2 2 0 FliG N-terminal domain Baculo_PEP_C PF04513.12 AMD19364.1 - 0.63 10.1 5.9 0.27 11.3 1.6 2.3 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 AMD19364.1 - 0.88 9.9 8.7 0.5 10.7 0.7 2.8 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 AMD19364.1 - 1.2 9.6 7.9 4.1 7.9 1.9 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region Cpn60_TCP1 PF00118.24 AMD19365.1 - 2.8e-161 537.5 2.2 3.2e-161 537.3 2.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pyr_redox_2 PF07992.14 AMD19365.1 - 0.022 14.0 0.1 0.047 12.9 0.1 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PNTB_4TM PF12769.7 AMD19365.1 - 0.032 14.7 0.0 0.23 12.0 0.0 2.2 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch PIR PF00399.19 AMD19366.1 - 3.9e-05 23.1 7.4 3.9e-05 23.1 7.4 3.5 3 0 0 3 3 3 1 Yeast PIR protein repeat Mito_fiss_reg PF05308.11 AMD19366.1 - 1.5 8.8 5.9 1.8 8.6 5.9 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 AMD19366.1 - 2.8 7.3 7.7 3.5 7.0 7.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FKBP_C PF00254.28 AMD19367.1 - 1.1e-33 115.4 0.0 1.3e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Eaf7 PF07904.13 AMD19368.1 - 4e-35 120.4 1.2 4e-35 120.4 1.2 1.6 2 0 0 2 2 2 1 Chromatin modification-related protein EAF7 S4 PF01479.25 AMD19369.1 - 1.9e-11 43.5 0.0 3.4e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain CAP_N PF01213.19 AMD19370.1 - 1.2e-104 350.2 0.8 1.5e-104 349.9 0.8 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 AMD19370.1 - 4.1e-58 195.4 1.7 6e-58 194.9 1.7 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Caprin-1_dimer PF18293.1 AMD19370.1 - 0.17 12.4 0.0 2.8 8.4 0.0 2.4 2 0 0 2 2 2 0 Caprin-1 dimerization domain Mito_fiss_reg PF05308.11 AMD19370.1 - 0.2 11.7 3.0 0.34 11.0 3.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 AMD19370.1 - 4.8 7.2 5.7 9.5 6.3 5.7 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SCIMP PF15050.6 AMD19371.1 - 0.053 14.0 0.1 0.081 13.4 0.1 1.2 1 0 0 1 1 1 0 SCIMP protein RRM_1 PF00076.22 AMD19371.1 - 0.072 12.9 0.0 0.39 10.6 0.0 2.3 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SF3b10 PF07189.11 AMD19372.1 - 9.4e-28 96.2 0.3 1e-27 96.0 0.3 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) THOC2_N PF16134.5 AMD19373.1 - 2.7e-138 462.4 11.8 2.7e-138 462.4 11.8 2.3 3 0 0 3 3 3 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 AMD19373.1 - 2e-36 125.8 18.6 3.2e-24 85.7 5.9 4.4 3 1 1 4 4 4 2 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 AMD19373.1 - 6.8e-21 74.1 0.1 2.6e-20 72.3 0.1 2.1 1 0 0 1 1 1 1 Transcription- and export-related complex subunit C2 PF00168.30 AMD19374.1 - 2.6e-13 50.1 0.0 4.3e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain Med7 PF05983.11 AMD19374.1 - 0.18 11.9 3.2 0.26 11.4 2.9 1.4 1 1 0 1 1 1 0 MED7 protein RNA_pol_3_Rpc31 PF11705.8 AMD19375.1 - 2.3e-52 178.5 6.2 2.3e-52 178.5 6.2 1.3 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 CNDH2_C PF16858.5 AMD19375.1 - 0.066 13.1 3.4 0.084 12.7 3.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2076 PF09849.9 AMD19375.1 - 0.64 10.0 10.0 1.2 9.2 10.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Cwf_Cwc_15 PF04889.12 AMD19375.1 - 1.3 8.7 13.7 2.2 7.9 13.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PGA2 PF07543.12 AMD19376.1 - 2.6e-15 56.6 9.0 6.6e-07 29.4 0.1 2.0 1 1 1 2 2 2 2 Protein trafficking PGA2 ATP-synt_B PF00430.18 AMD19376.1 - 0.038 14.1 4.2 0.16 12.1 4.1 1.8 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) CAP_GLY PF01302.25 AMD19377.1 - 2.2e-20 72.4 0.3 3.8e-20 71.7 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 AMD19377.1 - 5.8e-10 39.5 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Gemin6 PF06372.12 AMD19377.1 - 0.036 13.6 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Gemin6 protein LSM PF01423.22 AMD19378.1 - 1.7e-19 69.3 0.6 2e-19 69.0 0.6 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AMD19378.1 - 0.16 12.1 0.1 0.33 11.1 0.0 1.6 2 0 0 2 2 2 0 Ataxin 2 SM domain UPRTase PF14681.6 AMD19379.1 - 3.8e-76 255.1 0.0 4.5e-76 254.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase CoA_binding_2 PF13380.6 AMD19379.1 - 0.011 16.2 0.0 0.017 15.6 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain Pribosyltran PF00156.27 AMD19379.1 - 0.027 14.0 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Actin PF00022.19 AMD19380.1 - 1.9e-119 399.0 0.0 9.4e-119 396.6 0.0 1.8 1 1 0 1 1 1 1 Actin DUF2009 PF09418.10 AMD19381.1 - 4.1e-203 675.5 0.2 4.9e-203 675.3 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 AMD19381.1 - 0.00064 19.8 5.4 0.0014 18.7 5.4 1.5 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 AMD19381.1 - 0.001 19.3 4.2 0.0023 18.1 4.2 1.5 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain IBR PF01485.21 AMD19381.1 - 0.015 15.5 2.1 0.038 14.2 2.1 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Inhibitor_I36 PF03995.13 AMD19381.1 - 0.057 13.3 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Peptidase inhibitor family I36 PH PF00169.29 AMD19382.1 - 0.058 13.9 0.0 0.56 10.8 0.0 2.4 2 0 0 2 2 2 0 PH domain PH_9 PF15410.6 AMD19382.1 - 0.13 12.6 0.0 0.52 10.7 0.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain BH3 PF15285.6 AMD19382.1 - 0.75 9.6 3.1 10 6.0 0.5 3.0 3 0 0 3 3 3 0 Beclin-1 BH3 domain, Bcl-2-interacting Pga1 PF10333.9 AMD19384.1 - 4.2e-51 173.3 0.0 5.1e-51 173.0 0.0 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Ub-Mut7C PF14451.6 AMD19384.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Mut7-C ubiquitin fn3 PF00041.21 AMD19384.1 - 0.076 13.4 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Fibronectin type III domain Endosulfine PF04667.17 AMD19385.1 - 1.8e-31 108.1 0.6 2.8e-31 107.5 0.6 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region INSIG PF07281.12 AMD19386.1 - 1.2e-15 57.8 12.8 3.3e-15 56.3 6.7 2.9 1 1 1 2 2 2 2 Insulin-induced protein (INSIG) Thia_YuaJ PF09515.10 AMD19386.1 - 0.023 14.7 5.9 2 8.4 0.0 2.4 1 1 0 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) MOZART2 PF12926.7 AMD19386.1 - 0.029 14.0 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated WLM PF08325.10 AMD19387.1 - 8.6e-55 185.8 0.9 4.8e-54 183.4 0.9 1.9 1 1 0 1 1 1 1 WLM domain zf-AN1 PF01428.16 AMD19389.1 - 4.1e-10 39.6 9.4 6.1e-10 39.1 9.4 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger zf-CRD PF17979.1 AMD19389.1 - 0.15 12.2 4.1 0.46 10.6 4.1 1.8 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions Pkinase PF00069.25 AMD19390.1 - 2e-23 83.1 0.0 2e-23 83.1 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19390.1 - 4.4e-12 45.8 0.0 9e-12 44.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD19390.1 - 1.6e-09 37.1 4.9 1.8e-09 36.9 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase TFIIA PF03153.13 AMD19390.1 - 0.79 9.7 56.7 0.42 10.5 16.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Prefoldin_2 PF01920.20 AMD19392.1 - 7.6e-19 67.6 14.9 9e-19 67.4 14.9 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF4988 PF16378.5 AMD19392.1 - 0.011 15.4 1.0 0.011 15.4 1.0 1.6 2 0 0 2 2 2 0 Domain of unknown function ABC_tran_CTD PF16326.5 AMD19392.1 - 0.03 14.5 5.2 0.03 14.5 5.2 2.6 1 1 1 3 3 3 0 ABC transporter C-terminal domain XhlA PF10779.9 AMD19392.1 - 0.058 13.6 2.8 0.058 13.6 2.8 2.2 2 1 1 3 3 3 0 Haemolysin XhlA DUF1415 PF07209.12 AMD19392.1 - 0.11 12.2 1.6 0.16 11.7 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1415) Med4 PF10018.9 AMD19392.1 - 5.7 6.6 9.3 0.19 11.4 2.5 1.8 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 SLAM PF06214.11 AMD19393.1 - 0.019 15.0 0.3 0.023 14.7 0.3 1.1 1 0 0 1 1 1 0 Signaling lymphocytic activation molecule (SLAM) protein Far-17a_AIG1 PF04750.14 AMD19394.1 - 4.1e-15 55.7 7.3 5e-15 55.4 7.3 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Pkinase PF00069.25 AMD19395.1 - 4e-62 210.0 0.3 1.1e-41 143.0 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19395.1 - 1.5e-26 93.3 3.5 1.9e-20 73.2 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD19395.1 - 5.7e-05 22.2 3.0 6.6e-05 22.0 0.1 2.1 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 AMD19395.1 - 0.0016 17.9 0.0 0.0062 15.9 0.0 2.0 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD19395.1 - 0.0064 16.4 2.2 0.7 9.8 0.1 3.0 3 1 1 4 4 4 2 Phosphotransferase enzyme family Kinase-like PF14531.6 AMD19395.1 - 0.031 13.6 0.2 0.14 11.4 0.0 2.1 2 1 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 AMD19395.1 - 0.034 13.2 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 AMD19395.1 - 0.048 12.4 0.0 0.088 11.6 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase DUF3404 PF11884.8 AMD19395.1 - 0.054 12.7 0.8 0.11 11.7 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) TFIIA PF03153.13 AMD19395.1 - 6.7 6.6 19.0 15 5.5 19.0 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_L44 PF00935.19 AMD19396.1 - 3.2e-35 120.4 11.6 4.8e-35 119.9 11.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Chs7 PF12271.8 AMD19397.1 - 9e-108 360.0 18.9 1e-107 359.8 18.9 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF3671 PF12420.8 AMD19397.1 - 7.7 6.6 7.5 3.3 7.8 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function GTP_EFTU PF00009.27 AMD19399.1 - 4.5e-58 196.0 0.0 7.4e-58 195.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AMD19399.1 - 1.7e-12 47.2 0.1 6.3e-12 45.4 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AMD19399.1 - 2.3e-10 40.7 0.0 5.9e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 AMD19399.1 - 4.2e-09 36.4 0.1 1.9e-08 34.2 0.0 2.1 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_IV PF03764.18 AMD19399.1 - 4.6e-06 26.4 0.0 1.9e-05 24.4 0.0 2.1 1 0 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 AMD19399.1 - 0.016 15.3 0.0 0.071 13.2 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF3911 PF13050.6 AMD19400.1 - 0.075 13.2 0.5 0.18 11.9 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3911) DNA_RNApol_7kD PF03604.13 AMD19402.1 - 4.4e-17 61.5 1.7 5.7e-17 61.1 1.7 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 AMD19402.1 - 0.0016 18.4 0.5 0.0021 18.0 0.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 AMD19402.1 - 0.0042 17.1 0.1 0.0042 17.1 0.1 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TFIIS_C PF01096.18 AMD19402.1 - 0.0059 16.4 0.8 2.4 8.1 0.1 2.3 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) zinc_ribbon_10 PF10058.9 AMD19402.1 - 0.011 15.5 0.4 0.31 10.8 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf_UBZ PF18439.1 AMD19402.1 - 0.011 15.3 0.7 4.2 7.0 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zinc-ribbons_6 PF07191.12 AMD19402.1 - 0.016 15.2 0.4 0.021 14.8 0.4 1.2 1 0 0 1 1 1 0 zinc-ribbons MCM_OB PF17207.3 AMD19402.1 - 0.02 14.7 0.3 0.024 14.5 0.3 1.1 1 0 0 1 1 1 0 MCM OB domain zinc-ribbon_6 PF10005.9 AMD19402.1 - 0.022 15.4 0.3 0.03 15.0 0.3 1.2 1 0 0 1 1 1 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 AMD19402.1 - 0.029 14.3 2.1 0.047 13.6 2.1 1.4 1 1 0 1 1 1 0 SprT-like zinc ribbon domain TF_Zn_Ribbon PF08271.12 AMD19402.1 - 0.03 13.8 0.1 4.6 6.8 0.0 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding DUF2318 PF10080.9 AMD19402.1 - 0.048 13.8 0.1 0.052 13.7 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Ribosomal_L40e PF01020.17 AMD19402.1 - 0.072 13.0 2.1 0.096 12.6 2.1 1.2 1 0 0 1 1 1 0 Ribosomal L40e family DUF951 PF06107.11 AMD19402.1 - 0.11 12.5 1.9 0.83 9.6 0.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) FYDLN_acid PF09538.10 AMD19402.1 - 0.14 12.8 0.2 0.15 12.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn-ribbon_8 PF09723.10 AMD19402.1 - 0.17 12.0 2.8 0.73 10.0 2.8 1.9 1 1 2 3 3 3 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 AMD19402.1 - 0.27 11.0 3.5 3.3 7.5 0.6 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain zinc_ribbon_4 PF13717.6 AMD19402.1 - 0.35 10.8 5.2 2.5 8.1 5.3 2.2 1 1 0 1 1 1 0 zinc-ribbon domain bZIP_1 PF00170.21 AMD19403.1 - 6.7e-08 32.5 3.2 1.6e-07 31.3 3.2 1.6 1 0 0 1 1 1 1 bZIP transcription factor Aft1_OSA PF11785.8 AMD19403.1 - 1.1e-06 28.9 1.3 3.3e-06 27.4 0.3 2.2 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_2 PF07716.15 AMD19403.1 - 0.0012 18.9 7.0 0.0047 17.0 7.0 1.9 1 1 0 1 1 1 1 Basic region leucine zipper Aft1_HRA PF11786.8 AMD19403.1 - 0.02 15.3 3.9 0.02 15.3 3.9 2.6 2 1 1 3 3 3 0 Aft1 HRA domain PP1_bind PF15276.6 AMD19403.1 - 0.066 13.5 0.0 0.33 11.3 0.0 2.3 1 0 0 1 1 1 0 Protein phosphatase 1 binding DUF2570 PF10828.8 AMD19403.1 - 3 7.7 4.8 0.93 9.3 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) FAA_hydrolase PF01557.18 AMD19404.1 - 1.5e-47 162.1 0.0 1.9e-47 161.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family dCMP_cyt_deam_1 PF00383.23 AMD19405.1 - 1.4e-26 92.3 2.6 2.1e-26 91.7 2.6 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AMD19405.1 - 7.9e-15 54.8 0.1 1.2e-14 54.3 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 AMD19405.1 - 0.052 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain APOBEC4_like PF18774.1 AMD19405.1 - 0.092 12.7 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Cytidylate_kin2 PF13189.6 AMD19405.1 - 0.094 12.8 0.1 0.91 9.6 0.1 2.1 1 1 1 2 2 2 0 Cytidylate kinase-like family SNAD4 PF18750.1 AMD19405.1 - 0.1 12.7 0.2 0.25 11.5 0.1 1.7 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 PS_Dcarbxylase PF02666.15 AMD19406.1 - 8.8e-67 224.5 0.0 1.4e-66 223.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase ANAPC1 PF12859.7 AMD19407.1 - 7.8e-10 39.4 0.0 4.4e-09 37.0 0.0 2.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 AMPK1_CBM PF16561.5 AMD19408.1 - 1.2e-12 47.9 0.1 2.3e-12 47.0 0.1 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase RRM_1 PF00076.22 AMD19409.1 - 1.6e-26 91.9 0.1 2.8e-16 59.1 0.0 3.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AMD19409.1 - 0.0017 18.3 0.0 0.01 15.8 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 AMD19409.1 - 0.011 15.8 0.0 0.68 10.1 0.0 2.9 2 2 0 2 2 2 0 RNA recognition motif Gag_p30 PF02093.16 AMD19409.1 - 0.033 13.7 0.1 0.059 12.9 0.1 1.3 1 0 0 1 1 1 0 Gag P30 core shell protein Ribosomal_L22 PF00237.19 AMD19411.1 - 6e-22 77.8 0.0 2e-21 76.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e SHR3_chaperone PF08229.11 AMD19412.1 - 2.8e-73 244.9 0.5 3.3e-73 244.7 0.5 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Ribosomal_S3_C PF00189.20 AMD19413.1 - 1.9e-23 82.7 0.1 9.9e-23 80.5 0.2 2.0 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 AMD19413.1 - 8.5e-12 44.7 0.0 4.3e-11 42.5 0.0 2.0 2 0 0 2 2 2 1 KH domain Ras PF00071.22 AMD19414.1 - 7.6e-47 158.9 0.0 9.6e-47 158.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD19414.1 - 1.1e-20 74.0 0.0 3.4e-20 72.5 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD19414.1 - 2.1e-07 30.6 0.0 3.6e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AMD19414.1 - 0.00026 20.6 0.0 0.00075 19.1 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AMD19414.1 - 0.016 15.3 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 AMD19414.1 - 0.19 12.1 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain adh_short PF00106.25 AMD19415.1 - 1.2e-09 37.9 0.0 4e-09 36.2 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 AMD19415.1 - 1.7e-06 27.7 0.0 2.7e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD19415.1 - 2.1e-06 27.8 0.0 3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Nucleoporin_N PF08801.11 AMD19416.1 - 0.0044 15.8 0.1 1.2 7.9 0.1 2.6 2 0 0 2 2 2 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 AMD19416.1 - 0.013 15.8 0.0 0.12 12.7 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain YkyA PF10368.9 AMD19416.1 - 0.025 14.3 5.2 0.43 10.2 4.3 2.3 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein bZIP_1 PF00170.21 AMD19416.1 - 0.027 14.6 2.4 0.056 13.6 2.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor HPS3_N PF14761.6 AMD19416.1 - 0.093 12.3 0.3 12 5.4 0.0 2.6 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 Bap31_Bap29_C PF18035.1 AMD19416.1 - 0.13 12.3 2.6 0.26 11.3 2.6 1.4 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain RRM_1 PF00076.22 AMD19417.1 - 8.8e-08 31.9 0.0 1.8e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 AMD19418.1 - 3.6e-46 157.7 0.0 5.8e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19418.1 - 1.4e-21 77.0 0.0 2.3e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 AMD19418.1 - 0.0017 18.0 0.1 0.0029 17.2 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 AMD19418.1 - 0.0026 16.8 0.1 0.0026 16.8 0.1 1.8 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 AMD19418.1 - 0.034 13.8 0.1 0.13 11.8 0.0 1.8 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 AMD19418.1 - 0.052 12.9 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 AMD19418.1 - 0.24 11.3 0.0 0.49 10.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L11_N PF03946.14 AMD19419.1 - 4.2e-27 93.8 0.5 6.9e-27 93.1 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AMD19419.1 - 7.1e-25 87.3 0.1 1.1e-24 86.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain UCH PF00443.29 AMD19420.1 - 4e-52 177.3 1.6 7.6e-52 176.4 1.6 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD19420.1 - 3.4e-16 59.8 8.0 8.8e-14 51.8 0.1 2.7 2 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase JAB PF01398.21 AMD19421.1 - 4.9e-28 97.5 1.1 4.9e-27 94.3 0.0 2.3 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 AMD19421.1 - 3.5e-06 26.8 0.0 1.1e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 AMD19421.1 - 9.4e-05 22.5 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) PRP1_N PF06424.12 AMD19421.1 - 0.28 11.6 4.9 0.48 10.8 4.9 1.4 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal CNDH2_M PF16869.5 AMD19421.1 - 0.3 11.8 3.3 0.65 10.7 3.3 1.6 1 0 0 1 1 1 0 PF16858 Tim17 PF02466.19 AMD19423.1 - 5.5e-37 126.5 4.8 6.7e-37 126.3 4.8 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_Omp PF13488.6 AMD19423.1 - 0.21 11.6 0.3 0.21 11.6 0.3 2.6 3 0 0 3 3 3 0 Glycine zipper Arm PF00514.23 AMD19425.1 - 5.9e-87 283.4 18.2 7.1e-14 51.3 0.2 8.6 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 AMD19425.1 - 3.4e-27 94.7 7.9 1.1e-26 93.1 7.6 2.0 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 AMD19425.1 - 2.1e-21 75.2 0.8 3.5e-20 71.3 2.7 2.1 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 AMD19425.1 - 7.8e-20 71.0 2.5 1.8e-05 25.1 0.0 6.9 5 2 3 8 8 8 4 HEAT-like repeat HEAT_2 PF13646.6 AMD19425.1 - 2.7e-15 56.5 0.1 0.00015 22.1 0.0 4.9 1 1 5 6 6 6 5 HEAT repeats HEAT PF02985.22 AMD19425.1 - 4.2e-14 51.4 0.0 0.018 15.2 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat RICTOR_V PF14668.6 AMD19425.1 - 1.3e-06 28.5 2.5 0.029 14.6 0.0 5.0 3 3 3 6 6 6 1 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.20 AMD19425.1 - 1.2e-05 24.1 0.7 0.0011 17.7 0.2 2.4 1 1 2 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.13 AMD19425.1 - 1.6e-05 24.5 1.9 2.5 7.5 0.1 4.3 2 1 1 4 4 4 3 Armadillo-like V-ATPase_H_C PF11698.8 AMD19425.1 - 2.3e-05 24.5 0.4 0.51 10.5 0.0 4.3 4 2 1 5 5 5 3 V-ATPase subunit H Atx10homo_assoc PF09759.9 AMD19425.1 - 0.0027 17.7 0.1 1.7 8.7 0.0 4.1 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain FAST_1 PF06743.15 AMD19425.1 - 0.026 14.5 0.8 2.1 8.4 0.0 3.3 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 EAGR_box PF16713.5 AMD19426.1 - 0.00035 20.2 0.5 35 4.2 0.0 5.5 6 0 0 6 6 6 1 Enriched in aromatic and glycine Residues box Gp_dh_N PF00044.24 AMD19426.1 - 0.095 13.0 1.3 18 5.7 0.0 3.8 2 2 2 4 4 4 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain FARP PF01581.16 AMD19426.1 - 0.11 13.1 3.6 76 4.5 0.1 5.4 6 0 0 6 6 6 0 FMRFamide related peptide family Nucleoporin_FG PF13634.6 AMD19426.1 - 1.3 9.9 15.5 1.4 9.8 9.8 2.1 1 1 1 2 2 2 0 Nucleoporin FG repeat region GATase_4 PF13230.6 AMD19427.1 - 5.1e-16 58.4 0.0 1.3e-13 50.5 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 AMD19427.1 - 6.6e-09 36.1 0.0 1.2e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Tyr_Deacylase PF02580.16 AMD19428.1 - 3.6e-49 167.0 0.0 4e-49 166.8 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Chitin_synth_1 PF01644.17 AMD19429.1 - 2.7e-70 235.6 0.1 4e-70 235.0 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 AMD19429.1 - 1.5e-24 85.7 0.0 4.3e-24 84.3 0.0 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 AMD19429.1 - 2.5e-18 66.0 10.6 5e-16 58.4 1.1 2.5 2 1 1 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 AMD19429.1 - 2e-07 31.1 6.6 1.2e-06 28.6 6.5 2.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 AMD19429.1 - 0.13 12.1 0.0 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 SHS2_FTSA PF02491.20 AMD19430.1 - 0.047 14.1 0.1 0.13 12.6 0.1 1.7 1 0 0 1 1 1 0 SHS2 domain inserted in FTSA CDC13_N PF16853.5 AMD19431.1 - 1.5e-50 171.6 0.3 2.7e-50 170.8 0.3 1.5 1 0 0 1 1 1 1 Cell division control protein 13 N-terminus Cdc13_OB4_dimer PF18233.1 AMD19431.1 - 1.3e-34 118.8 0.0 2.6e-34 117.8 0.0 1.5 1 0 0 1 1 1 1 Cdc13 OB4 dimerization domain POT1 PF02765.17 AMD19431.1 - 9.6e-06 25.5 0.1 2.7e-05 24.0 0.1 1.8 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Cdc13_OB2 PF18691.1 AMD19431.1 - 0.0044 17.1 0.2 0.068 13.2 0.0 2.5 2 0 0 2 2 2 1 Cell division control protein 13, OB2 domain SUR7 PF06687.12 AMD19432.1 - 4.7e-36 124.4 3.3 9.3e-36 123.4 3.3 1.5 1 0 0 1 1 1 1 SUR7/PalI family Rap1-DNA-bind PF09197.10 AMD19433.1 - 2.7e-47 159.8 4.2 1e-43 148.4 1.0 3.0 3 0 0 3 3 3 2 Rap1, DNA-binding Rap1_C PF11626.8 AMD19433.1 - 4.1e-24 84.5 0.0 1.7e-22 79.3 0.0 3.2 3 0 0 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.31 AMD19433.1 - 2.5e-14 53.2 4.0 9.6e-12 44.9 0.0 4.3 4 1 0 4 4 4 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.11 AMD19433.1 - 4e-08 33.3 1.7 9.1e-05 22.6 0.0 2.9 3 0 0 3 3 3 2 Rap1 Myb domain BRCT_2 PF16589.5 AMD19433.1 - 4.5e-07 30.2 0.0 2.4e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 AMD19433.1 - 0.0001 22.6 0.0 0.00037 20.8 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Myb_DNA-bind_6 PF13921.6 AMD19433.1 - 0.0043 17.3 0.6 0.3 11.4 0.0 3.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain SLIDE PF09111.10 AMD19433.1 - 0.03 14.3 0.7 0.19 11.8 0.0 2.7 3 0 0 3 3 3 0 SLIDE RskA PF10099.9 AMD19433.1 - 0.057 13.7 2.7 0.093 13.0 2.7 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Hpt PF01627.23 AMD19434.1 - 2.2e-10 40.7 0.0 2.6e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Hpt domain MgsA_C PF12002.8 AMD19435.1 - 2.3e-54 183.8 0.3 6.9e-54 182.3 0.2 1.8 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 AMD19435.1 - 1.8e-23 82.6 0.1 5.6e-23 81.1 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 AMD19435.1 - 5.2e-17 62.5 0.1 9.5e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AMD19435.1 - 3e-14 53.1 0.1 1.5e-13 50.8 0.0 2.2 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AMD19435.1 - 7.7e-08 32.9 0.1 5.3e-05 23.7 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 AMD19435.1 - 1.3e-07 31.8 0.0 2.7e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AMD19435.1 - 1.4e-07 31.6 0.1 3.3e-07 30.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AMD19435.1 - 1.5e-06 28.5 0.5 9.2e-05 22.7 0.5 2.7 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AMD19435.1 - 6.7e-05 22.4 0.1 0.037 13.4 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 AMD19435.1 - 9.8e-05 22.1 0.0 0.00033 20.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 AMD19435.1 - 0.00013 21.7 0.0 0.0018 18.0 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_19 PF13245.6 AMD19435.1 - 0.00028 21.2 0.3 0.34 11.2 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_3 PF07726.11 AMD19435.1 - 0.00029 20.7 0.1 0.00057 19.8 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 AMD19435.1 - 0.00091 19.1 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial dnaA protein AAA_2 PF07724.14 AMD19435.1 - 0.0012 19.0 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RNF220 PF15926.5 AMD19435.1 - 0.0015 18.2 0.5 0.0027 17.4 0.5 1.4 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 ResIII PF04851.15 AMD19435.1 - 0.0015 18.5 0.5 0.32 11.0 0.1 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF815 PF05673.13 AMD19435.1 - 0.0016 17.7 0.0 0.0027 16.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 AMD19435.1 - 0.0018 18.8 0.0 0.014 16.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 AMD19435.1 - 0.0022 18.1 0.2 0.013 15.7 0.1 2.3 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 AMD19435.1 - 0.003 17.1 0.1 0.0056 16.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 AMD19435.1 - 0.0034 17.9 0.0 0.012 16.1 0.0 2.0 2 0 0 2 2 1 1 ABC transporter IstB_IS21 PF01695.17 AMD19435.1 - 0.0042 16.8 0.0 0.0095 15.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 AMD19435.1 - 0.0048 17.3 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 AMD19435.1 - 0.0067 15.7 0.0 0.022 14.0 0.0 1.7 1 1 0 2 2 2 1 TIP49 P-loop domain TniB PF05621.11 AMD19435.1 - 0.01 15.2 0.1 0.41 10.0 0.0 2.5 1 1 1 2 2 2 0 Bacterial TniB protein DNA_pol3_delta2 PF13177.6 AMD19435.1 - 0.01 15.6 0.0 0.98 9.2 0.0 2.5 1 1 0 1 1 1 0 DNA polymerase III, delta subunit DHDPS PF00701.22 AMD19435.1 - 0.019 13.7 0.0 0.034 12.9 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Roc PF08477.13 AMD19435.1 - 0.022 15.0 0.1 0.07 13.4 0.0 1.9 2 0 0 2 2 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 AMD19435.1 - 0.026 14.2 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 AMD19435.1 - 0.03 14.1 0.0 0.064 13.0 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 AMD19435.1 - 0.032 14.1 0.0 0.083 12.8 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 AMD19435.1 - 0.036 14.0 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 AMD19435.1 - 0.068 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sgf11 PF08209.11 AMD19435.1 - 0.11 12.1 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) MMR_HSR1 PF01926.23 AMD19435.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Hydrolase_6 PF13344.6 AMD19436.1 - 4.7e-28 97.3 0.0 1.2e-27 95.9 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AMD19436.1 - 2e-13 50.2 0.0 3.9e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AMD19436.1 - 8.4e-13 49.1 0.0 5.6e-11 43.1 0.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AMD19436.1 - 8.6e-07 29.2 0.0 0.019 15.1 0.0 2.4 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Glyco_transf_22 PF03901.17 AMD19437.1 - 9.8e-94 314.9 24.9 1.3e-93 314.5 24.9 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CytB6-F_Fe-S PF08802.10 AMD19437.1 - 0.59 10.2 2.7 1.3 9.2 0.8 2.6 1 1 1 2 2 2 0 Cytochrome B6-F complex Fe-S subunit DUF2070 PF09843.9 AMD19437.1 - 2.1 6.5 17.6 0.053 11.8 9.8 2.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2070) Adenylsucc_synt PF00709.21 AMD19438.1 - 1.2e-176 587.8 0.0 1.3e-176 587.6 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase POP1 PF06978.11 AMD19439.1 - 9.4e-76 254.4 13.7 1.6e-75 253.6 13.7 1.4 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 AMD19439.1 - 2.4e-30 104.7 2.1 3.7e-30 104.1 1.2 1.8 2 0 0 2 2 2 1 POPLD (NUC188) domain ANT PF03374.14 AMD19439.1 - 0.012 15.9 0.0 4.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain DUF1389 PF07146.11 AMD19439.1 - 0.16 11.2 1.6 0.74 9.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1389) GDPD_2 PF13653.6 AMD19440.1 - 0.0066 16.9 0.2 0.016 15.7 0.2 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ssu72 PF04722.13 AMD19441.1 - 1.3e-84 282.5 0.0 1.4e-84 282.4 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein Peptidase_C54 PF03416.19 AMD19442.1 - 9e-84 281.2 0.0 1.2e-83 280.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 G-patch PF01585.23 AMD19443.1 - 1e-11 44.6 0.8 2.6e-11 43.2 0.8 1.8 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 AMD19443.1 - 9e-08 32.0 0.0 3.3e-07 30.2 0.0 2.0 1 0 0 1 1 1 1 R3H domain Vpu PF00558.19 AMD19443.1 - 0.21 11.4 0.0 0.21 11.4 0.0 2.9 3 0 0 3 3 3 0 Vpu protein SID PF11778.8 AMD19444.1 - 1.8e-54 183.5 5.4 1.4e-53 180.6 5.4 2.7 1 0 0 1 1 1 1 Septation initiation PKcGMP_CC PF16808.5 AMD19444.1 - 0.00042 20.1 39.3 0.37 10.7 4.2 9.3 7 1 1 8 8 8 2 Coiled-coil N-terminus of cGMP-dependent protein kinase Spc7 PF08317.11 AMD19444.1 - 0.0036 16.2 117.4 0.055 12.3 30.0 5.3 2 2 4 6 6 6 6 Spc7 kinetochore protein Fez1 PF06818.15 AMD19444.1 - 0.0083 16.6 103.6 0.52 10.7 25.9 6.5 1 1 4 5 5 4 1 Fez1 TPR_MLP1_2 PF07926.12 AMD19444.1 - 0.0092 16.0 21.9 0.0092 16.0 21.9 6.7 2 2 3 5 5 5 3 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 AMD19444.1 - 0.026 14.8 112.9 0.1 12.8 25.9 6.4 2 2 4 6 6 6 0 Autophagy protein 16 (ATG16) DUF5082 PF16888.5 AMD19444.1 - 0.029 14.6 0.8 0.029 14.6 0.8 8.5 2 1 8 10 10 7 0 Domain of unknown function (DUF5082) DUF3584 PF12128.8 AMD19444.1 - 0.14 9.6 99.0 0.086 10.4 29.6 3.5 2 1 1 4 4 4 0 Protein of unknown function (DUF3584) Myosin_tail_1 PF01576.19 AMD19444.1 - 1.3 6.7 109.8 0.31 8.8 24.0 4.6 1 1 2 3 3 3 0 Myosin tail HTH_Tnp_Tc3_1 PF11427.8 AMD19444.1 - 1.5 8.7 6.6 2.8 7.9 0.9 3.9 3 1 1 4 4 4 0 Tc3 transposase MscS_porin PF12795.7 AMD19444.1 - 2.2 7.8 106.4 0.66 9.5 19.6 5.3 2 2 2 5 5 5 0 Mechanosensitive ion channel porin domain AAA_13 PF13166.6 AMD19444.1 - 3 6.4 93.4 2.4 6.7 26.1 4.3 1 1 1 3 3 3 0 AAA domain DnaJ PF00226.31 AMD19445.1 - 5.3e-24 84.1 0.7 5.3e-24 84.1 0.7 2.7 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 AMD19445.1 - 1.9e-07 31.1 12.2 1.6e-06 28.2 5.1 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AMD19445.1 - 4e-05 23.9 8.0 0.03 14.6 4.0 2.8 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 AMD19445.1 - 0.00053 20.3 6.9 0.14 12.7 0.3 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD19445.1 - 0.0017 19.0 4.7 0.41 11.6 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AMD19445.1 - 0.0028 18.0 9.0 0.061 13.7 3.5 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type RPT PF13446.6 AMD19445.1 - 0.37 10.8 3.2 0.85 9.6 0.1 3.0 3 0 0 3 3 3 0 A repeated domain in UCH-protein GST_C PF00043.25 AMD19446.1 - 3.8e-22 78.3 0.0 7.3e-22 77.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AMD19446.1 - 7.6e-19 67.8 0.0 1.7e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 AMD19446.1 - 1.1e-10 41.8 0.0 2.1e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 AMD19446.1 - 5.7e-09 36.2 0.0 1.6e-08 34.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 AMD19446.1 - 0.00039 20.5 0.0 0.00081 19.5 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 AMD19446.1 - 0.049 13.7 0.0 0.086 12.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MFA1_2 PF17317.2 AMD19447.1 - 1.8e-14 53.2 0.7 2.3e-14 52.8 0.7 1.2 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 Elongin_A PF06881.11 AMD19448.1 - 3.5e-18 66.0 16.4 1e-16 61.4 1.0 2.5 2 1 1 3 3 3 2 RNA polymerase II transcription factor SIII (Elongin) subunit A EXOSC1 PF10447.9 AMD19449.1 - 2.5e-37 127.8 0.8 2.5e-37 127.8 0.8 1.7 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 PDZ_5 PF17817.1 AMD19450.1 - 0.02 15.2 0.0 0.073 13.4 0.0 2.0 1 0 0 1 1 1 0 PDZ domain Globin PF00042.22 AMD19451.1 - 2.3e-05 24.9 0.0 4.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Globin PHtD_u1 PF16645.5 AMD19451.1 - 0.15 12.5 4.0 0.69 10.4 4.0 2.1 1 0 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein Med16 PF11635.8 AMD19452.1 - 1.9e-199 664.3 6.2 2.2e-199 664.1 6.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 Peptidase_S8 PF00082.22 AMD19453.1 - 1.9e-34 119.3 2.9 3.4e-34 118.5 2.9 1.4 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 AMD19453.1 - 2.1e-25 88.6 0.9 4.5e-25 87.5 0.9 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF1180 PF06679.12 AMD19453.1 - 0.032 14.6 0.0 0.081 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Gram_pos_anchor PF00746.21 AMD19453.1 - 0.21 11.6 0.0 0.5 10.3 0.0 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif SR-25 PF10500.9 AMD19453.1 - 5.4 6.6 7.3 9.3 5.8 7.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_C1_2 PF03051.15 AMD19454.1 - 8.3e-158 525.7 1.2 9.5e-158 525.5 1.2 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 AMD19454.1 - 9e-08 32.5 0.1 0.0051 16.9 0.2 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Fe_hyd_lg_C PF02906.14 AMD19455.1 - 1.3e-66 224.7 0.0 1.8e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain G6PD_C PF02781.16 AMD19456.1 - 5.3e-108 360.6 0.0 7.2e-108 360.2 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 AMD19456.1 - 3.7e-60 203.6 0.0 1e-59 202.2 0.0 1.8 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain TetR_C_30 PF17939.1 AMD19456.1 - 0.11 12.8 0.0 1.2 9.3 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain NUC130_3NT PF08158.12 AMD19456.1 - 0.12 12.7 0.1 1.1 9.6 0.1 2.3 2 0 0 2 2 2 0 NUC130/3NT domain RhoGAP PF00620.27 AMD19457.1 - 9.2e-35 119.7 0.7 3.8e-34 117.7 0.1 2.4 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 AMD19457.1 - 2.8e-19 69.1 57.5 2.4e-08 34.1 6.3 4.6 4 0 0 4 4 4 4 LIM domain ATG2_CAD PF13329.6 AMD19458.1 - 8.6e-32 110.0 0.5 8.6e-32 110.0 0.5 3.0 3 0 0 3 3 3 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 AMD19458.1 - 3.6e-29 101.0 0.3 1.5e-28 99.0 0.2 2.1 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 AMD19458.1 - 0.032 14.0 0.0 0.27 11.0 0.0 2.6 2 0 0 2 2 2 0 Vacuolar-sorting-associated 13 protein C-terminal Asp PF00026.23 AMD19459.1 - 1.3e-69 235.1 0.5 1.5e-69 234.8 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD19459.1 - 1e-08 35.6 1.0 4.5e-08 33.5 1.0 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AMD19459.1 - 0.0097 16.5 0.1 12 6.7 0.0 2.9 3 0 0 3 3 3 2 Aspartyl protease Aldo_ket_red PF00248.21 AMD19460.1 - 8.5e-42 143.3 0.0 5.5e-40 137.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family AA_permease_2 PF13520.6 AMD19461.1 - 3.1e-76 256.9 48.2 3.7e-76 256.7 48.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AMD19461.1 - 6e-19 68.0 37.1 6e-19 68.0 37.1 1.9 1 1 0 2 2 2 2 Amino acid permease SUI1 PF01253.22 AMD19462.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AMD19462.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) MATalpha_HMGbox PF04769.12 AMD19463.1 - 5.2e-16 58.6 0.2 5.2e-16 58.6 0.2 1.6 2 0 0 2 2 2 1 Mating-type protein MAT alpha 1 HMG-box Homeobox_KN PF05920.11 AMD19464.1 - 1e-08 34.9 0.5 2.7e-08 33.6 0.5 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 AMD19464.1 - 3.1e-06 26.9 0.7 3.1e-06 26.9 0.7 2.4 3 0 0 3 3 3 1 Homeodomain Homez PF11569.8 AMD19464.1 - 0.00024 20.5 0.0 0.00056 19.3 0.0 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez GvpG PF05120.12 AMD19464.1 - 0.065 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Gas vesicle protein G UPF0154 PF03672.13 AMD19464.1 - 0.066 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) HTH_28 PF13518.6 AMD19464.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Sec10 PF07393.11 AMD19466.1 - 1.1e-24 86.9 0.2 1.3e-24 86.6 0.2 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 SRA PF18491.1 AMD19466.1 - 0.061 13.4 0.1 0.076 13.1 0.1 1.3 1 0 0 1 1 1 0 SET and RING associated domain CRISPR_Cas2 PF09827.9 AMD19466.1 - 0.11 12.7 0.8 16 5.7 0.1 2.3 2 0 0 2 2 2 0 CRISPR associated protein Cas2 PALP PF00291.25 AMD19467.1 - 7.6e-55 186.4 0.0 8.5e-55 186.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GIDA PF01134.22 AMD19467.1 - 0.0042 16.2 0.0 0.014 14.5 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 AMD19467.1 - 0.1 11.6 0.0 0.54 9.3 0.1 2.0 2 1 1 3 3 3 0 FAD binding domain Vac17 PF17321.2 AMD19468.1 - 1.2e-28 100.7 10.1 2.1e-28 100.0 10.1 1.3 1 1 0 1 1 1 1 Vacuole-related protein 17 SCPU PF05229.15 AMD19468.1 - 0.057 13.8 0.2 0.15 12.5 0.2 1.6 1 0 0 1 1 1 0 Spore Coat Protein U domain MRC1 PF09444.10 AMD19469.1 - 1.5e-36 126.1 12.9 1.5e-36 126.1 12.9 5.4 7 1 0 7 7 7 1 MRC1-like domain NfeD PF01957.18 AMD19469.1 - 0.19 12.1 0.1 2.3 8.6 0.0 2.5 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding KH_8 PF17903.1 AMD19470.1 - 1.7e-31 108.1 0.8 5.6e-31 106.5 0.1 2.2 2 0 0 2 2 2 1 Krr1 KH1 domain EMP24_GP25L PF01105.24 AMD19470.1 - 0.1 12.5 0.3 0.16 11.9 0.3 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF543 PF04418.12 AMD19472.1 - 4.7e-31 106.6 0.5 5.1e-31 106.5 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Peptidase_M3 PF01432.20 AMD19473.1 - 4.5e-133 444.9 0.6 4.5e-133 444.9 0.6 1.6 2 0 0 2 2 2 1 Peptidase family M3 FliX PF10768.9 AMD19473.1 - 0.044 14.3 0.2 0.099 13.2 0.2 1.5 1 0 0 1 1 1 0 Class II flagellar assembly regulator Tli4_N PF18443.1 AMD19473.1 - 0.35 11.2 1.9 2.7 8.3 0.3 2.5 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain ELP6 PF09807.9 AMD19474.1 - 0.093 12.1 1.4 0.31 10.4 0.2 2.0 2 0 0 2 2 2 0 Elongation complex protein 6 SEO_C PF14577.6 AMD19475.1 - 0.039 13.4 0.3 0.061 12.8 0.3 1.2 1 0 0 1 1 1 0 Sieve element occlusion C-terminus Voltage_CLC PF00654.20 AMD19476.1 - 6.9e-79 265.7 24.2 6.9e-79 265.7 24.2 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel DUF2737 PF10930.8 AMD19476.1 - 0.17 11.5 0.2 0.37 10.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) DUF3091 PF11291.8 AMD19477.1 - 0.036 14.2 0.1 0.089 13.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3091) Nicastrin PF05450.15 AMD19477.1 - 0.092 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Nicastrin DUF2830 PF11125.8 AMD19477.1 - 0.12 12.4 0.6 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2830) MT-A70 PF05063.14 AMD19478.1 - 1.5e-13 51.0 0.0 2.6e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 MT-A70 Spb1_C PF07780.12 AMD19479.1 - 6.1e-85 284.2 28.4 6.1e-85 284.2 28.4 2.8 3 0 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 AMD19479.1 - 2.6e-53 180.8 0.1 5e-53 179.8 0.1 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 AMD19479.1 - 4.9e-46 156.5 13.7 4.9e-46 156.5 13.7 5.8 5 1 1 6 6 6 1 Domain of unknown function (DUF3381) PIG-X PF08320.12 AMD19480.1 - 6.4e-35 121.0 0.0 1.2e-34 120.1 0.0 1.5 1 0 0 1 1 1 1 PIG-X / PBN1 UCR_14kD PF02271.16 AMD19482.1 - 5.8e-39 132.1 0.0 6.8e-39 131.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit She9_MDM33 PF05546.11 AMD19482.1 - 0.075 12.8 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 She9 / Mdm33 family ATP_transf PF09830.9 AMD19483.1 - 1.1e-17 64.0 0.0 1.9e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.23 AMD19483.1 - 4e-06 27.5 0.0 2.2e-05 25.1 0.0 2.3 1 1 1 2 2 2 1 HIT domain DUF4922 PF16269.5 AMD19483.1 - 0.0019 18.0 0.2 0.0052 16.6 0.2 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4922) DUF4931 PF16285.5 AMD19483.1 - 0.025 13.9 0.0 0.05 12.9 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4931) Fumble PF03630.14 AMD19484.1 - 1.4e-119 399.1 2.5 2e-118 395.4 2.5 1.9 1 1 0 1 1 1 1 Fumble Kre28 PF17097.5 AMD19485.1 - 2.1e-86 290.2 26.2 2.3e-86 290.0 26.2 1.0 1 0 0 1 1 1 1 Spindle pole body component GCV_H PF01597.19 AMD19485.1 - 0.037 13.9 1.3 0.15 12.0 1.1 2.0 2 0 0 2 2 2 0 Glycine cleavage H-protein KORA PF16509.5 AMD19485.1 - 0.073 13.4 1.1 1.3 9.4 0.2 2.4 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor COG2 PF06148.11 AMD19485.1 - 0.42 10.7 7.3 0.66 10.1 1.4 2.7 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DNA_pol3_a_NI PF14480.6 AMD19485.1 - 1.5 8.9 6.7 8 6.5 0.1 3.6 4 0 0 4 4 4 0 DNA polymerase III polC-type N-terminus I DUF1216 PF06746.11 AMD19485.1 - 3 7.9 8.8 0.35 10.9 3.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) Laminin_II PF06009.12 AMD19485.1 - 7.6 6.6 9.0 0.31 11.1 1.2 2.5 2 1 1 3 3 3 0 Laminin Domain II RPAP1_C PF08620.10 AMD19486.1 - 3.9e-28 97.3 0.0 7e-28 96.5 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 AMD19486.1 - 5.6e-16 58.0 1.5 5.6e-16 58.0 1.5 2.4 2 0 0 2 2 2 1 RPAP1-like, N-terminal Pmp3 PF01679.17 AMD19487.1 - 3e-11 43.3 4.0 3.5e-11 43.1 4.0 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Tic110 PF16940.5 AMD19488.1 - 9.3 4.6 7.7 8.9 4.7 7.7 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter ArfGap PF01412.18 AMD19489.1 - 4.5e-27 94.4 1.6 5.5e-27 94.2 0.2 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 AMD19489.1 - 1.2e-12 48.2 0.3 1.2e-12 48.2 0.3 3.1 3 1 1 4 4 4 1 PH domain BAR_3 PF16746.5 AMD19489.1 - 2.5e-08 33.9 0.4 4.7e-08 33.0 0.4 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH_9 PF15410.6 AMD19489.1 - 0.0031 17.9 0.3 0.0099 16.2 0.3 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 AMD19489.1 - 0.0079 16.0 0.1 0.018 14.8 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 AMD19489.1 - 0.029 14.8 4.3 0.39 11.2 4.3 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain PH_8 PF15409.6 AMD19489.1 - 0.034 14.4 0.3 0.084 13.2 0.3 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain Pkinase PF00069.25 AMD19490.1 - 1e-69 234.8 0.0 1.4e-69 234.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19490.1 - 1.3e-46 159.0 0.0 2e-46 158.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19490.1 - 1.1e-05 24.9 0.0 0.0043 16.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AMD19490.1 - 0.0048 15.7 0.0 0.0072 15.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 AMD19490.1 - 0.12 11.4 0.1 12 4.7 0.0 2.5 3 0 0 3 3 3 0 Haspin like kinase domain Recep_L_domain PF01030.24 AMD19491.1 - 7.2e-10 39.0 6.5 0.0005 20.2 0.1 4.1 2 1 3 5 5 5 4 Receptor L domain LRR_4 PF12799.7 AMD19491.1 - 0.0013 19.1 9.9 1.5 9.3 0.2 5.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Zn_clus PF00172.18 AMD19492.1 - 1.5e-05 25.0 11.6 3e-05 24.0 11.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EMC1_C PF07774.13 AMD19493.1 - 3e-66 223.1 1.7 1.2e-65 221.2 1.7 2.0 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 AMD19493.1 - 0.00028 20.5 0.1 0.05 13.2 0.0 3.2 3 1 0 3 3 3 1 PQQ-like domain PQQ PF01011.21 AMD19493.1 - 0.0037 17.1 0.1 0.036 14.0 0.0 2.6 2 0 0 2 2 2 1 PQQ enzyme repeat FAIM1 PF06905.13 AMD19493.1 - 0.084 12.6 0.5 0.41 10.3 0.0 2.3 2 0 0 2 2 2 0 Fas apoptotic inhibitory molecule (FAIM1) Mgr1 PF08602.10 AMD19494.1 - 3.5e-143 477.1 0.0 4e-143 476.9 0.0 1.0 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit Topo_Zn_Ribbon PF08272.11 AMD19494.1 - 0.059 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Topoisomerase I zinc-ribbon-like Thioredoxin PF00085.20 AMD19495.1 - 5.4e-58 193.4 0.2 3.9e-29 100.7 0.1 3.5 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 AMD19495.1 - 2e-24 86.6 6.9 7.6e-19 68.3 0.9 3.5 3 1 1 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.13 AMD19495.1 - 6.6e-11 42.1 0.3 7.2e-06 25.6 0.0 2.9 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 AMD19495.1 - 3e-09 37.3 0.4 0.00084 19.8 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 AMD19495.1 - 5.9e-08 32.8 0.1 0.0022 18.1 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 AMD19495.1 - 1.8e-06 27.9 0.1 0.00097 19.1 0.1 2.8 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 AMD19495.1 - 0.00029 21.1 0.1 0.64 10.4 0.0 3.7 3 2 0 3 3 3 1 Thioredoxin-like Redoxin PF08534.10 AMD19495.1 - 0.00033 20.4 0.1 0.28 10.9 0.0 2.6 2 0 0 2 2 2 2 Redoxin Thioredoxin_5 PF13743.6 AMD19495.1 - 0.0046 16.7 0.3 0.049 13.3 0.0 2.9 4 1 0 4 4 4 1 Thioredoxin Thioredoxin_4 PF13462.6 AMD19495.1 - 0.11 12.7 2.1 0.81 9.8 0.0 3.2 3 1 0 3 3 3 0 Thioredoxin GRASP55_65 PF04495.14 AMD19496.1 - 2.8e-36 124.9 0.0 7.9e-36 123.4 0.0 1.7 2 0 0 2 2 2 1 GRASP55/65 PDZ-like domain Hexokinase_2 PF03727.16 AMD19497.1 - 1e-73 247.8 0.0 1.4e-73 247.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 AMD19497.1 - 6.1e-73 245.0 0.1 1.4e-72 243.8 0.1 1.6 2 0 0 2 2 2 1 Hexokinase WD40 PF00400.32 AMD19498.1 - 8.7e-18 64.4 5.1 0.017 16.0 0.0 7.0 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19498.1 - 1.3e-06 28.6 0.0 1.1 9.6 0.0 4.7 3 3 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 AMD19498.1 - 0.035 13.4 0.3 0.3 10.3 0.0 2.1 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Nbas_N PF15492.6 AMD19498.1 - 0.041 13.2 0.0 0.51 9.6 0.0 2.4 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 AMD19498.1 - 0.081 12.9 0.7 27 4.8 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat RNase_P_p30 PF01876.16 AMD19498.1 - 0.1 12.1 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 RNase P subunit p30 ATG22 PF11700.8 AMD19499.1 - 3.7e-152 507.3 26.6 4.3e-152 507.1 26.6 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 AMD19499.1 - 1.3e-06 27.7 35.6 1.6e-06 27.3 7.1 3.1 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF1761 PF08570.10 AMD19499.1 - 0.13 12.6 14.3 0.33 11.2 0.1 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1761) La PF05383.17 AMD19500.1 - 1.3e-17 63.6 0.1 4.6e-17 61.8 0.0 2.0 2 0 0 2 2 2 1 La domain Med9 PF07544.13 AMD19501.1 - 0.033 14.3 5.0 0.54 10.4 0.3 3.1 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 TRCF PF03461.15 AMD19501.1 - 0.08 13.3 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 TRCF domain Glutaredoxin PF00462.24 AMD19502.1 - 1.8e-13 50.4 0.0 3.1e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 AMD19502.1 - 0.015 15.6 0.0 0.02 15.2 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Ribosomal_L33 PF00471.20 AMD19502.1 - 0.038 14.4 0.2 0.05 14.1 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L33 Thioredoxin_4 PF13462.6 AMD19502.1 - 0.083 13.0 0.2 1.3 9.2 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin GAT PF03127.14 AMD19503.1 - 0.00044 20.5 0.1 0.0015 18.8 0.1 1.9 1 1 0 1 1 1 1 GAT domain SelR PF01641.18 AMD19504.1 - 1.4e-48 163.9 1.5 1.6e-48 163.7 1.5 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 AMD19504.1 - 0.00041 20.5 0.4 0.00074 19.7 0.4 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_10 PF10058.9 AMD19504.1 - 0.0071 16.0 2.4 0.36 10.6 0.1 2.3 2 0 0 2 2 2 2 Predicted integral membrane zinc-ribbon metal-binding protein HECT_2 PF09814.9 AMD19504.1 - 0.084 11.7 2.6 0.83 8.4 0.4 2.0 1 1 0 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Tnp_zf-ribbon_2 PF13842.6 AMD19504.1 - 1.2 10.0 7.8 8.4 7.3 0.5 2.8 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon DUF3128 PF11326.8 AMD19505.1 - 1.6e-23 82.9 3.1 1.8e-23 82.7 3.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) CHCH PF06747.13 AMD19505.1 - 0.019 15.1 1.0 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 CHCH domain RA PF00788.23 AMD19506.1 - 5.5e-16 59.0 0.1 3.3e-15 56.5 0.1 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SAM_Ste50p PF09235.10 AMD19506.1 - 4.5e-14 52.5 2.2 6.5e-08 32.7 0.1 2.5 2 0 0 2 2 2 2 Ste50p, sterile alpha motif SAM_1 PF00536.30 AMD19506.1 - 0.021 15.3 0.2 1.9 9.0 0.1 2.6 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) MbeD_MobD PF04899.12 AMD19506.1 - 0.043 13.9 0.0 0.08 13.1 0.0 1.4 1 0 0 1 1 1 0 MbeD/MobD like Clr2 PF10383.9 AMD19506.1 - 0.058 14.2 0.3 0.12 13.1 0.3 1.7 1 1 0 1 1 1 0 Transcription-silencing protein Clr2 RRM_Rrp7 PF17799.1 AMD19507.1 - 4.1e-39 134.0 0.4 7.3e-39 133.2 0.4 1.4 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 AMD19507.1 - 1.1e-25 90.0 7.5 1.9e-25 89.3 7.5 1.4 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF5093 PF17011.5 AMD19507.1 - 0.013 15.8 0.0 0.013 15.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) 3-alpha PF03475.14 AMD19507.1 - 0.076 12.9 0.3 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 3-alpha domain FERM_N PF09379.10 AMD19507.1 - 0.087 12.8 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 FERM N-terminal domain FOXP-CC PF16159.5 AMD19507.1 - 0.14 12.8 6.4 2.7 8.7 0.0 3.2 3 0 0 3 3 3 0 FOXP coiled-coil domain Colicin-DNase PF12639.7 AMD19507.1 - 0.83 10.5 5.6 0.68 10.8 3.3 2.0 2 0 0 2 2 2 0 DNase/tRNase domain of colicin-like bacteriocin Complex1_LYR_2 PF13233.6 AMD19508.1 - 2e-18 66.9 0.5 2.6e-18 66.6 0.5 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 AMD19508.1 - 9.4e-10 38.4 0.1 2.2e-09 37.2 0.0 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) DUF4028 PF13220.6 AMD19508.1 - 0.074 12.8 0.8 0.15 11.9 0.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4028) Complex1_LYR_1 PF13232.6 AMD19508.1 - 0.1 13.2 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 Complex1_LYR-like Histidinol_dh PF00815.20 AMD19509.1 - 3e-159 530.4 2.9 4.7e-159 529.8 2.9 1.3 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 AMD19509.1 - 2.7e-25 88.0 0.1 7.1e-25 86.6 0.1 1.8 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 AMD19509.1 - 2.8e-13 50.1 0.2 7.5e-13 48.7 0.2 1.7 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MATH PF00917.26 AMD19509.1 - 0.03 14.5 0.0 0.061 13.5 0.0 1.4 1 0 0 1 1 1 0 MATH domain CAP_GLY PF01302.25 AMD19510.1 - 5.9e-13 48.6 2.2 6.6e-13 48.5 0.7 1.9 2 0 0 2 2 2 1 CAP-Gly domain GAS PF13851.6 AMD19510.1 - 2.5e-05 23.7 30.4 0.00067 19.1 20.6 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding CLIP1_ZNF PF16641.5 AMD19510.1 - 0.00018 21.3 0.8 0.00027 20.7 0.8 1.3 1 0 0 1 1 1 1 CLIP1 zinc knuckle PilJ PF13675.6 AMD19510.1 - 0.015 15.3 5.9 1.2 9.2 0.3 2.6 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Seryl_tRNA_N PF02403.22 AMD19510.1 - 0.036 14.3 1.6 0.036 14.3 1.6 3.5 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 AMD19510.1 - 1.2 9.2 28.0 5.9 7.0 21.5 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 AMD19510.1 - 1.2 9.5 24.7 1 9.8 23.1 1.5 1 1 0 1 1 1 0 Fez1 DUF4200 PF13863.6 AMD19510.1 - 3.3 8.1 33.6 10 6.5 9.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 AMD19510.1 - 5.2 7.6 35.2 2.6 8.6 22.9 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 AMD19510.1 - 7.4 4.4 14.0 10 3.9 14.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.11 AMD19510.1 - 7.4 6.6 34.7 0.28 11.3 2.1 2.8 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus TPR_2 PF07719.17 AMD19511.1 - 0.24 11.6 0.0 0.46 10.7 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Dak2 PF02734.17 AMD19511.1 - 1.8 8.4 8.8 0.11 12.4 0.6 2.0 1 1 1 2 2 2 0 DAK2 domain CAP PF00188.26 AMD19512.1 - 6.2e-18 65.8 0.0 8.4e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SH3_9 PF14604.6 AMD19513.1 - 1.2e-06 28.3 0.0 2.2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AMD19513.1 - 0.0029 17.2 0.0 0.0057 16.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SKG6 PF08693.10 AMD19513.1 - 0.024 14.0 1.0 0.044 13.2 1.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain SH3_2 PF07653.17 AMD19513.1 - 0.029 14.0 0.0 0.069 12.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain DUF347 PF03988.12 AMD19513.1 - 0.085 13.1 0.3 0.38 11.0 0.0 2.1 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) DUF485 PF04341.12 AMD19513.1 - 0.13 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 AA_permease PF00324.21 AMD19514.1 - 2.4e-130 435.4 33.0 2.7e-130 435.2 33.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD19514.1 - 1.4e-31 109.8 32.3 1.7e-31 109.5 32.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1640 PF07798.11 AMD19514.1 - 0.08 13.0 0.5 0.14 12.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Rad60-SLD PF11976.8 AMD19515.1 - 1.7e-18 66.2 0.1 2.2e-18 65.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 AMD19515.1 - 3.8e-11 42.6 0.0 4.5e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Pkinase PF00069.25 AMD19516.1 - 3.3e-72 243.0 0.0 8.5e-72 241.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19516.1 - 7.7e-36 123.7 0.0 1.5e-35 122.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 AMD19516.1 - 5.6e-30 103.5 0.6 1.1e-29 102.5 0.6 1.6 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 AMD19516.1 - 9.1e-06 25.2 0.0 4.2e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like TMEMspv1-c74-12 PF11044.8 AMD19516.1 - 0.53 10.3 2.5 4.4 7.4 0.0 2.7 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Cu-oxidase_2 PF07731.14 AMD19517.1 - 4.3e-36 123.7 6.7 3.9e-30 104.4 1.2 3.4 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 AMD19517.1 - 4.3e-25 88.7 0.3 4.1e-24 85.5 0.1 2.5 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 AMD19517.1 - 4.9e-24 84.6 0.7 4.9e-24 84.6 0.7 3.3 4 0 0 4 4 4 1 Multicopper oxidase PSP1 PF04468.12 AMD19518.1 - 7e-42 141.6 0.1 7e-42 141.6 0.1 1.9 2 0 0 2 2 2 1 PSP1 C-terminal conserved region PBP PF01161.20 AMD19519.1 - 1.3e-14 54.6 0.0 1.8e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PAP2 PF01569.21 AMD19520.1 - 1.3e-24 86.5 4.4 2.7e-24 85.5 4.4 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 AMD19520.1 - 8.6e-06 25.6 6.3 8.6e-06 25.6 6.3 2.2 3 1 0 3 3 3 1 PAP2 superfamily PAP2_C PF14360.6 AMD19520.1 - 0.0015 19.0 2.4 0.012 16.1 1.5 2.7 2 0 0 2 2 2 1 PAP2 superfamily C-terminal S-AdoMet_synt_C PF02773.16 AMD19521.1 - 4.9e-64 214.5 0.0 9.2e-64 213.6 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 AMD19521.1 - 1.7e-45 153.7 0.1 3.2e-45 152.9 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 AMD19521.1 - 9.3e-45 151.8 0.0 1.9e-44 150.8 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 AMD19521.1 - 0.029 13.1 0.1 0.13 11.0 0.1 1.9 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Vta1 PF04652.16 AMD19522.1 - 2.2e-28 99.0 1.0 3.7e-28 98.3 0.1 1.7 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 AMD19522.1 - 5.1e-14 51.7 0.3 5.1e-14 51.7 0.3 2.1 2 0 0 2 2 2 1 Vta1 C-terminal domain Swi6_N PF18530.1 AMD19523.1 - 5.4e-16 58.7 0.0 1.9e-15 56.9 0.0 1.9 1 0 0 1 1 1 1 Swi6 N-terminal domain Ank_5 PF13857.6 AMD19523.1 - 9.7e-13 48.1 0.3 1.3e-05 25.3 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD19523.1 - 2.3e-10 39.8 0.7 0.0006 20.1 0.1 3.7 3 0 0 3 3 2 2 Ankyrin repeat Ank_2 PF12796.7 AMD19523.1 - 7.7e-10 39.2 0.0 0.0026 18.3 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 AMD19523.1 - 2.1e-08 34.2 2.2 0.0022 18.4 0.2 3.4 3 0 0 3 3 2 2 Ankyrin repeat Ank_4 PF13637.6 AMD19523.1 - 8.5e-08 32.6 0.5 0.011 16.3 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Phage_GPO PF05929.11 AMD19523.1 - 0.12 11.9 5.0 0.057 13.0 0.9 2.1 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF724 PF05266.14 AMD19523.1 - 1.7 8.4 6.9 8 6.2 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) OmpH PF03938.14 AMD19523.1 - 2 8.8 9.7 2.3 8.5 4.8 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Tropomyosin_1 PF12718.7 AMD19523.1 - 4.6 7.4 16.5 4.7 7.4 8.3 2.6 2 0 0 2 2 2 0 Tropomyosin like FapA PF03961.13 AMD19523.1 - 5.6 5.5 8.0 6.8 5.2 3.0 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A Med9 PF07544.13 AMD19523.1 - 6.5 6.9 12.6 16 5.6 0.5 3.4 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Fez1 PF06818.15 AMD19523.1 - 7.6 6.9 13.7 28 5.1 13.7 1.9 1 1 0 1 1 1 0 Fez1 FHA PF00498.26 AMD19524.1 - 2e-05 24.9 0.0 5.5e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 FHA domain Phosphoprotein PF00922.17 AMD19524.1 - 0.16 11.6 3.5 0.19 11.3 0.6 2.1 2 0 0 2 2 2 0 Vesiculovirus phosphoprotein Ribosomal_L37e PF01907.19 AMD19525.1 - 5.3e-29 100.1 10.9 8.9e-29 99.4 10.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 AMD19525.1 - 0.0046 17.0 1.3 0.0068 16.4 1.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.18 AMD19525.1 - 0.015 15.4 0.5 0.018 15.1 0.5 1.3 1 0 0 1 1 1 0 SelR domain DUF1258 PF06869.12 AMD19525.1 - 0.018 14.6 0.6 0.018 14.6 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) GATA PF00320.27 AMD19525.1 - 0.17 11.5 5.3 0.74 9.5 1.1 2.4 1 1 1 2 2 2 0 GATA zinc finger Zn-ribbon_8 PF09723.10 AMD19525.1 - 0.18 11.9 2.0 0.34 11.0 2.0 1.5 1 1 0 1 1 1 0 Zinc ribbon domain DUF35_N PF12172.8 AMD19525.1 - 0.19 11.7 2.4 0.39 10.7 2.4 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HypA PF01155.19 AMD19525.1 - 0.2 11.7 1.0 0.27 11.3 1.0 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AMD19525.1 - 0.24 10.9 3.2 0.58 9.7 3.2 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AMD19525.1 - 0.38 10.5 4.7 6.6 6.6 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain LCD1 PF09798.9 AMD19526.1 - 2.9e-163 544.7 16.1 3.3e-163 544.5 16.1 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein OmpH PF03938.14 AMD19526.1 - 0.061 13.7 4.7 0.13 12.6 4.7 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1765 PF08578.10 AMD19526.1 - 1.3 9.5 7.7 4.3 7.8 4.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1765) FapA PF03961.13 AMD19526.1 - 2.9 6.4 5.5 4.6 5.7 5.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A EMG1 PF03587.14 AMD19527.1 - 1.7e-78 262.8 0.0 2e-78 262.5 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase RP854 PF17460.2 AMD19527.1 - 0.031 14.0 0.0 0.046 13.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein RP854 LapA_dom PF06305.11 AMD19528.1 - 0.0046 16.8 1.0 0.41 10.5 0.0 2.9 2 0 0 2 2 2 2 Lipopolysaccharide assembly protein A domain Arch_flagellin PF01917.16 AMD19528.1 - 0.61 10.3 4.8 0.31 11.2 1.1 2.4 2 0 0 2 2 2 0 Archaebacterial flagellin PH PF00169.29 AMD19529.1 - 4.5e-08 33.6 0.1 3.7e-06 27.4 0.0 2.5 2 0 0 2 2 2 2 PH domain ABC_membrane PF00664.23 AMD19530.1 - 1.3e-64 218.5 5.5 1.7e-64 218.2 5.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AMD19530.1 - 2.7e-32 112.2 0.0 8.6e-32 110.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 AMD19530.1 - 1.6e-08 34.3 0.3 2.3e-06 27.2 0.0 2.4 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 AMD19530.1 - 0.00031 20.5 0.0 0.34 10.6 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_16 PF13191.6 AMD19530.1 - 0.00032 21.1 0.0 0.0014 19.0 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 AMD19530.1 - 0.0013 19.1 0.2 0.029 14.8 0.2 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD19530.1 - 0.0015 18.8 0.3 0.015 15.6 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AMD19530.1 - 0.0068 16.4 0.0 0.23 11.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AMD19530.1 - 0.015 15.8 0.0 0.15 12.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AMD19530.1 - 0.022 14.6 0.0 0.068 13.1 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase ABC_ATPase PF09818.9 AMD19530.1 - 0.024 13.4 0.2 0.043 12.6 0.2 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_7 PF12775.7 AMD19530.1 - 0.025 14.1 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 AMD19530.1 - 0.031 14.0 0.0 0.074 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 AMD19530.1 - 0.07 13.3 0.1 0.28 11.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 AMD19530.1 - 0.088 12.6 0.2 2.1 8.1 0.2 2.4 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.6 AMD19530.1 - 0.098 12.4 0.1 0.26 11.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain ISP1_C PF18161.1 AMD19530.1 - 0.15 12.1 0.1 0.39 10.7 0.1 1.7 1 0 0 1 1 1 0 ISP1 C-terminal AAA_28 PF13521.6 AMD19530.1 - 0.16 12.2 0.0 0.48 10.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain Abhydrolase_1 PF00561.20 AMD19531.1 - 4.4e-49 167.4 0.1 7.1e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AMD19531.1 - 2.6e-05 24.9 1.9 5.2e-05 24.0 1.9 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD19531.1 - 0.0015 17.9 0.3 0.0081 15.5 0.1 2.2 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 AMD19531.1 - 0.0087 16.2 0.0 0.04 14.0 0.0 2.0 2 0 0 2 2 2 1 TAP-like protein Esterase PF00756.20 AMD19531.1 - 0.035 13.7 0.8 0.068 12.8 0.2 1.7 2 0 0 2 2 2 0 Putative esterase GRAM PF02893.20 AMD19532.1 - 3.4e-32 110.7 1.0 4e-22 78.3 0.0 2.9 3 0 0 3 3 3 2 GRAM domain Glyco_transf_28 PF03033.20 AMD19532.1 - 3.1e-29 101.8 0.0 9.1e-29 100.3 0.0 1.9 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 AMD19532.1 - 1.5e-09 37.2 0.0 3.7e-09 35.9 0.0 1.5 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH PF00169.29 AMD19532.1 - 2.5e-05 24.8 0.2 0.00018 22.0 0.1 2.4 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 AMD19532.1 - 0.015 15.7 0.6 0.11 12.9 0.6 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain Glyco_tran_28_C PF04101.16 AMD19532.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Exo_endo_phos PF03372.23 AMD19533.1 - 3.3e-13 49.7 0.4 4.6e-13 49.2 0.4 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TraG_N PF07916.11 AMD19533.1 - 1.7 7.4 6.3 2.3 7.0 6.3 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Spindle_Spc25 PF08234.12 AMD19534.1 - 2.7e-17 62.7 0.0 6.2e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 KASH_CCD PF14662.6 AMD19534.1 - 0.0037 17.1 17.7 0.006 16.4 17.7 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH PV-1 PF06637.11 AMD19534.1 - 0.0096 14.8 13.7 0.011 14.5 13.7 1.1 1 0 0 1 1 1 1 PV-1 protein (PLVAP) Atg14 PF10186.9 AMD19534.1 - 0.011 14.8 12.1 0.014 14.5 12.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 AMD19534.1 - 0.022 12.7 10.1 0.027 12.4 10.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 AMD19534.1 - 0.023 13.6 12.8 0.033 13.1 12.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 AMD19534.1 - 0.037 13.6 8.5 0.041 13.4 8.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 AMD19534.1 - 0.068 13.7 24.1 0.064 13.8 22.2 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region ADIP PF11559.8 AMD19534.1 - 0.095 12.8 17.4 0.19 11.8 17.4 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 AMD19534.1 - 0.14 12.3 19.7 0.25 11.6 19.7 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 YabA PF06156.13 AMD19534.1 - 0.18 12.4 13.0 0.074 13.7 9.8 1.9 1 1 1 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 AMD19534.1 - 2.8 7.2 8.6 4.5 6.5 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SYF2 PF08231.12 AMD19534.1 - 3.5 8.0 11.7 11 6.4 11.6 1.7 1 1 0 1 1 1 0 SYF2 splicing factor FapA PF03961.13 AMD19534.1 - 4.6 5.7 10.8 6.2 5.3 10.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_11 PF13086.6 AMD19534.1 - 5 6.8 9.4 7.4 6.3 9.4 1.2 1 0 0 1 1 1 0 AAA domain MerR-DNA-bind PF09278.11 AMD19534.1 - 5.4 7.6 13.3 0.8 10.3 5.3 2.9 1 1 1 2 2 2 0 MerR, DNA binding Per1 PF04080.13 AMD19535.1 - 2.3e-82 276.6 17.4 3e-82 276.2 17.4 1.1 1 0 0 1 1 1 1 Per1-like family DUF1230 PF06799.11 AMD19535.1 - 1.4 9.1 4.8 0.62 10.2 0.8 2.4 3 0 0 3 3 3 0 Conserved in the green lineage and diatoms 27 HCO3_cotransp PF00955.21 AMD19536.1 - 1.6e-80 271.4 14.3 1.6e-41 142.8 2.1 2.1 1 1 1 2 2 2 2 HCO3- transporter family Peptidase_M1 PF01433.20 AMD19538.1 - 1.4e-05 24.8 0.0 2.8e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 AMD19538.1 - 0.0035 17.5 1.1 1.1 9.4 0.0 2.7 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain HEAT_2 PF13646.6 AMD19538.1 - 0.024 15.0 0.0 2.3 8.7 0.0 2.4 2 0 0 2 2 2 0 HEAT repeats DUF4379 PF14311.6 AMD19538.1 - 0.04 14.3 2.1 0.13 12.7 2.1 1.8 1 0 0 1 1 1 0 Probable Zinc-ribbon domain Sad1_UNC PF07738.13 AMD19539.1 - 3.6e-30 104.7 0.0 8e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Cyclin_N PF00134.23 AMD19540.1 - 3.8e-38 130.1 0.8 2.5e-37 127.5 0.5 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain SAM_4 PF18017.1 AMD19540.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Cyclin_C PF02984.19 AMD19540.1 - 0.025 14.7 0.5 0.13 12.3 0.1 2.3 2 0 0 2 2 2 0 Cyclin, C-terminal domain zf-met PF12874.7 AMD19540.1 - 0.032 14.6 0.4 0.22 11.9 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PsiB PF06290.11 AMD19540.1 - 0.033 13.7 0.2 0.66 9.5 0.0 2.4 2 0 0 2 2 2 0 Plasmid SOS inhibition protein (PsiB) TIMELESS PF04821.14 AMD19541.1 - 3.3e-85 285.7 0.5 8.1e-85 284.4 0.5 1.7 1 0 0 1 1 1 1 Timeless protein Rogdi_lz PF10259.9 AMD19541.1 - 0.025 14.0 0.1 0.058 12.8 0.1 1.6 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein DUF1604 PF07713.13 AMD19541.1 - 3.4 7.5 4.7 18 5.2 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1604) Aa_trans PF01490.18 AMD19542.1 - 2.8e-76 256.9 35.5 3.2e-76 256.7 35.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Claudin_2 PF13903.6 AMD19542.1 - 9.6 5.9 12.0 4.1 7.1 0.9 3.2 1 1 2 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Sec2p PF06428.11 AMD19543.1 - 2.9e-26 91.2 15.1 2.9e-26 91.2 15.1 3.5 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p MPS2 PF17060.5 AMD19543.1 - 5.9e-05 22.5 14.6 9.9e-05 21.8 14.6 1.3 1 0 0 1 1 1 1 Monopolar spindle protein 2 Tropomyosin_1 PF12718.7 AMD19543.1 - 0.0004 20.5 19.4 0.0004 20.5 19.4 2.4 1 1 1 2 2 2 1 Tropomyosin like DUF745 PF05335.13 AMD19543.1 - 0.0037 17.0 18.5 0.0066 16.2 17.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF745) Laminin_II PF06009.12 AMD19543.1 - 0.0091 16.0 4.8 0.0091 16.0 4.8 3.0 1 1 2 3 3 3 1 Laminin Domain II DUF2959 PF11172.8 AMD19543.1 - 0.025 14.7 14.7 0.041 14.0 14.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) Serine_rich PF08824.10 AMD19543.1 - 0.098 12.7 12.8 0.11 12.5 10.1 2.3 1 1 1 2 2 2 0 Serine rich protein interaction domain Tubulin_C PF03953.17 AMD19543.1 - 0.1 12.8 0.2 0.24 11.6 0.2 1.5 1 0 0 1 1 1 0 Tubulin C-terminal domain Prominin PF05478.11 AMD19543.1 - 0.2 9.6 16.6 0.3 9.0 16.6 1.2 1 0 0 1 1 1 0 Prominin Sipho_Gp157 PF05565.11 AMD19543.1 - 0.25 11.4 14.8 0.55 10.2 14.8 1.6 1 0 0 1 1 1 0 Siphovirus Gp157 HMMR_N PF15905.5 AMD19543.1 - 0.52 9.7 31.1 0.95 8.9 31.1 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF3584 PF12128.8 AMD19543.1 - 0.79 7.2 23.4 1.2 6.6 23.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CorA PF01544.18 AMD19543.1 - 1.4 8.2 14.2 0.11 11.8 7.4 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein ATG16 PF08614.11 AMD19543.1 - 2 8.6 28.7 4.4 7.5 28.7 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Lebercilin PF15619.6 AMD19543.1 - 2.1 7.9 33.1 0.11 12.2 21.7 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Exonuc_VII_L PF02601.15 AMD19543.1 - 2.8 7.4 23.3 12 5.4 23.3 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit ApoO PF09769.9 AMD19543.1 - 3 7.8 7.5 12 5.9 1.1 2.5 1 1 1 2 2 2 0 Apolipoprotein O GAS PF13851.6 AMD19543.1 - 3.4 7.0 32.1 27 4.0 32.5 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FUSC PF04632.12 AMD19543.1 - 3.6 6.0 5.5 4.9 5.6 5.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family CREPT PF16566.5 AMD19543.1 - 4.8 7.3 24.3 2.4 8.3 11.1 2.4 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF5082 PF16888.5 AMD19543.1 - 5.6 7.3 20.9 33 4.8 0.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Macoilin PF09726.9 AMD19543.1 - 9.4 4.7 21.2 18 3.8 21.2 1.4 1 0 0 1 1 1 0 Macoilin family FH2 PF02181.23 AMD19544.1 - 1.2e-86 291.2 8.7 1.2e-86 291.2 8.7 3.1 4 0 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 AMD19544.1 - 4e-44 150.6 17.2 6.4e-44 149.9 0.0 4.6 4 0 0 4 4 4 2 Diaphanous FH3 Domain Drf_GBD PF06371.13 AMD19544.1 - 4.2e-29 101.5 0.4 4.2e-29 101.5 0.4 3.8 4 1 0 4 4 4 1 Diaphanous GTPase-binding Domain AA_permease PF00324.21 AMD19545.1 - 1.6e-139 465.6 43.5 2e-139 465.3 43.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD19545.1 - 3.2e-28 98.7 53.2 2.3e-27 95.9 53.2 1.9 1 1 0 1 1 1 1 Amino acid permease TMIE PF16038.5 AMD19545.1 - 1.8 8.5 3.8 0.64 9.9 0.1 2.1 2 0 0 2 2 2 0 TMIE protein AA_permease PF00324.21 AMD19546.1 - 2.2e-131 438.7 41.7 2.5e-131 438.6 41.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD19546.1 - 3.9e-33 114.9 45.7 4.8e-33 114.6 45.7 1.1 1 0 0 1 1 1 1 Amino acid permease Tmemb_55A PF09788.9 AMD19546.1 - 0.65 9.0 1.7 1.4 8.0 1.7 1.5 1 0 0 1 1 1 0 Transmembrane protein 55A PI3_PI4_kinase PF00454.27 AMD19547.1 - 1.5e-37 129.7 0.1 8.6e-37 127.3 0.1 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 AMD19547.1 - 1.8e-18 66.2 0.3 4.8e-18 64.9 0.3 1.8 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 AMD19547.1 - 9.3e-07 28.4 1.0 2.3e-06 27.1 1.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 AMD19547.1 - 0.027 13.8 0.0 0.063 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Tam41_Mmp37 PF09139.11 AMD19548.1 - 4.8e-90 302.3 12.4 3e-85 286.5 3.4 2.4 2 1 1 3 3 3 2 Phosphatidate cytidylyltransferase, mitochondrial Ist1 PF03398.14 AMD19549.1 - 8.9e-53 178.6 2.4 1.3e-52 178.0 2.4 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway WD40_4 PF16300.5 AMD19549.1 - 0.15 11.9 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Type of WD40 repeat TPR_19 PF14559.6 AMD19550.1 - 7.5e-15 55.2 4.6 0.00012 22.5 0.1 6.4 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 AMD19550.1 - 9e-11 41.0 14.0 1.6 9.0 0.1 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 AMD19550.1 - 1.8e-10 41.3 0.5 0.0032 18.1 0.1 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 AMD19550.1 - 2.9e-09 36.7 15.6 0.15 12.5 0.3 8.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD19550.1 - 6.1e-09 36.0 7.0 0.21 11.9 0.1 6.4 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 AMD19550.1 - 4.3e-08 33.3 3.9 0.75 10.6 0.0 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD19550.1 - 5.7e-06 26.5 10.6 0.34 11.1 0.3 4.8 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 AMD19550.1 - 6.4e-06 26.6 0.0 11 7.1 0.0 5.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 AMD19550.1 - 2.3e-05 24.6 4.3 0.61 10.5 0.2 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 AMD19550.1 - 2.8e-05 23.7 10.8 0.0075 15.9 0.7 5.3 5 0 0 5 5 5 1 TPR repeat TPR_8 PF13181.6 AMD19550.1 - 3.6e-05 23.6 17.3 0.013 15.7 0.1 8.5 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 AMD19550.1 - 4.1e-05 23.6 0.0 0.47 10.6 0.0 3.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 AMD19550.1 - 6.9e-05 22.5 24.4 2 8.4 0.0 8.6 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 AMD19550.1 - 0.00021 20.6 0.5 2.5 7.2 0.0 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPPII_N PF12583.8 AMD19550.1 - 0.021 15.4 0.9 11 6.6 0.1 2.7 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal Alkyl_sulf_dimr PF14863.6 AMD19550.1 - 0.2 12.1 3.9 0.68 10.4 0.1 2.8 3 0 0 3 3 2 0 Alkyl sulfatase dimerisation DUF3687 PF12459.8 AMD19550.1 - 0.25 10.9 1.5 1.1 8.8 0.1 2.6 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein Tau95_N PF17682.1 AMD19550.1 - 0.4 10.9 3.6 23 5.2 0.1 3.1 2 1 0 2 2 2 0 Tau95 Triple barrel domain TPR_10 PF13374.6 AMD19550.1 - 1.4 8.9 6.5 84 3.2 0.1 5.5 5 1 1 6 6 5 0 Tetratricopeptide repeat UFD1 PF03152.14 AMD19551.1 - 2.8e-69 232.0 0.0 3.5e-69 231.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Spa1_C PF18218.1 AMD19551.1 - 0.11 13.0 0.2 0.3 11.5 0.1 1.8 2 0 0 2 2 2 0 Lantibiotic immunity protein Spa1 C-terminal domain CRAL_TRIO PF00650.20 AMD19552.1 - 6.6e-40 136.4 0.1 1.1e-39 135.7 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AMD19552.1 - 1.5e-15 57.1 0.2 5.7e-15 55.2 0.2 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AMD19552.1 - 0.0022 18.1 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain UBA_4 PF14555.6 AMD19552.1 - 0.0039 17.0 0.1 0.012 15.4 0.0 1.8 2 0 0 2 2 2 1 UBA-like domain DUF1769 PF08588.10 AMD19552.1 - 0.017 15.3 0.1 0.045 14.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) DnaJ PF00226.31 AMD19553.1 - 2.8e-15 56.2 0.5 4.9e-15 55.4 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain YIF1 PF03878.15 AMD19554.1 - 3.8e-74 249.2 7.5 4.7e-74 248.9 7.5 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 AMD19554.1 - 9.3 5.9 12.3 0.038 13.7 3.2 1.7 2 0 0 2 2 2 0 Yip1 domain DUF1744 PF08490.12 AMD19555.1 - 1.1e-136 455.5 1.7 2e-136 454.7 1.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 AMD19555.1 - 3.5e-79 266.4 1.8 3.5e-78 263.1 0.3 2.6 2 1 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 AMD19555.1 - 3.6e-17 62.2 4.9 6.3e-14 51.5 1.0 3.5 3 1 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 AMD19555.1 - 3.3e-05 23.7 0.5 0.00023 20.9 0.5 2.4 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AMD19555.1 - 0.00086 19.3 0.1 0.0065 16.5 0.0 2.6 2 0 0 2 2 2 1 RNase_H superfamily zf-CHY PF05495.12 AMD19555.1 - 5.3 7.6 10.2 15 6.1 10.2 1.8 1 0 0 1 1 1 0 CHY zinc finger ORC5_C PF14630.6 AMD19556.1 - 4.5e-61 206.9 0.5 5.9e-61 206.5 0.5 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 AMD19556.1 - 2.6e-08 34.4 0.0 8.3e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 AMD19556.1 - 0.00082 19.4 0.9 0.026 14.6 0.9 2.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AMD19556.1 - 0.0014 18.9 0.0 0.0048 17.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 AMD19556.1 - 0.0025 17.8 0.3 0.012 15.6 0.0 2.1 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 AMD19556.1 - 0.0037 17.6 0.0 0.009 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain GYF PF02213.16 AMD19557.1 - 5e-09 35.7 4.4 1.3e-08 34.4 4.4 1.8 1 0 0 1 1 1 1 GYF domain S8_pro-domain PF16470.5 AMD19557.1 - 2.1 9.2 9.5 0.6 10.9 0.2 2.9 3 0 0 3 3 3 0 Peptidase S8 pro-domain DUF4604 PF15377.6 AMD19557.1 - 2.2 8.6 14.1 0.56 10.6 5.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Yae1_N PF09811.9 AMD19558.1 - 6.8e-12 44.9 3.3 9.6e-12 44.4 3.3 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal HMA PF00403.26 AMD19559.1 - 1.7e-10 41.2 0.4 2e-10 41.0 0.4 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Gp_dh_C PF02800.20 AMD19559.1 - 0.036 13.7 0.2 0.071 12.7 0.2 1.5 1 1 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Fer2_BFD PF04324.15 AMD19559.1 - 0.053 13.9 0.1 1.5 9.2 0.0 2.2 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain Dsl1_C PF11989.8 AMD19560.1 - 4.2e-74 248.5 6.1 4.2e-74 248.5 6.1 2.3 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal Dsl1_N PF11988.8 AMD19560.1 - 2.4e-70 237.3 16.3 2.4e-70 237.3 16.3 2.4 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 N terminal NfI_DNAbd_pre-N PF10524.9 AMD19560.1 - 0.14 12.0 0.2 0.34 10.8 0.2 1.6 1 0 0 1 1 1 0 Nuclear factor I protein pre-N-terminus PH PF00169.29 AMD19561.1 - 3.7e-12 46.7 0.3 1.5e-11 44.7 0.1 2.3 2 0 0 2 2 2 1 PH domain BAR_3 PF16746.5 AMD19561.1 - 3.1e-11 43.4 0.7 9.9e-11 41.8 0.7 1.9 1 0 0 1 1 1 1 BAR domain of APPL family VASt PF16016.5 AMD19561.1 - 2.8e-10 40.8 0.3 1.3e-09 38.7 0.2 2.2 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain BLOC1_2 PF10046.9 AMD19561.1 - 0.21 11.9 5.1 0.99 9.8 0.1 3.9 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-RING_9 PF13901.6 AMD19561.1 - 2.7 7.9 7.4 0.68 9.9 0.5 3.0 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon Palm_thioest PF02089.15 AMD19562.1 - 7.8e-07 29.2 0.0 2e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 AMD19562.1 - 1.3e-06 28.3 0.0 2.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 AMD19562.1 - 1.6e-06 27.8 0.0 3.6e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 Putative serine esterase (DUF676) DUF915 PF06028.11 AMD19562.1 - 7.4e-06 25.5 0.1 0.00016 21.1 0.1 2.6 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) LCAT PF02450.15 AMD19562.1 - 0.00026 20.3 0.0 0.00039 19.7 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.20 AMD19562.1 - 0.00086 19.0 0.0 0.0037 17.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AMD19562.1 - 0.038 14.6 0.0 0.049 14.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family RRM_1 PF00076.22 AMD19563.1 - 2.1e-14 53.1 0.1 6.4e-14 51.5 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.21 AMD19563.1 - 6.8e-14 52.4 0.0 9.9e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_5 PF13893.6 AMD19563.1 - 0.0093 15.6 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_3 PF01494.19 AMD19564.1 - 5.7e-20 71.8 0.1 5.4e-13 48.9 0.0 3.1 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 AMD19564.1 - 0.00022 20.4 0.1 0.00079 18.6 0.0 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 AMD19564.1 - 0.00063 19.1 0.0 0.0027 17.0 0.0 1.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 AMD19564.1 - 0.0012 17.7 0.1 0.025 13.4 0.1 2.2 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 AMD19564.1 - 0.0045 17.2 0.1 0.0098 16.1 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AMD19564.1 - 0.0061 16.2 0.1 0.011 15.3 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 AMD19564.1 - 0.0086 15.3 0.1 0.018 14.3 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 AMD19564.1 - 0.0092 15.3 0.0 0.033 13.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AMD19564.1 - 0.013 14.6 0.2 0.02 14.0 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain SE PF08491.10 AMD19564.1 - 0.041 12.9 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase NAD_binding_9 PF13454.6 AMD19564.1 - 0.085 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding HI0933_like PF03486.14 AMD19564.1 - 0.096 11.4 0.0 0.17 10.5 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Pterin_bind PF00809.22 AMD19565.1 - 3.8e-51 174.1 0.0 1.4e-50 172.2 0.0 1.9 1 1 0 1 1 1 1 Pterin binding enzyme FolB PF02152.18 AMD19565.1 - 3.7e-38 130.5 0.7 7.8e-20 71.5 0.9 2.6 2 0 0 2 2 2 2 Dihydroneopterin aldolase HPPK PF01288.20 AMD19565.1 - 3e-33 114.7 0.0 8.7e-33 113.2 0.0 1.8 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) zf-CCHC PF00098.23 AMD19566.1 - 9.8e-51 167.7 54.4 8.9e-09 35.0 1.7 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 AMD19566.1 - 2e-11 43.4 43.4 0.0061 16.3 0.4 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 AMD19566.1 - 3.1e-05 23.6 35.4 0.17 11.7 0.9 7.0 4 1 3 7 7 7 5 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 AMD19566.1 - 0.00094 19.1 43.1 2.7 8.0 0.9 7.1 2 2 4 6 6 6 5 Zinc knuckle zf-C2H2_10 PF16588.5 AMD19566.1 - 0.023 14.4 3.0 0.023 14.4 3.0 6.5 7 0 0 7 7 7 0 C2H2 zinc-finger Anti-TRAP PF15777.5 AMD19566.1 - 1.2 9.2 33.1 3.2 7.8 0.5 5.6 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein PRP21_like_P PF12230.8 AMD19567.1 - 1.3e-30 106.9 13.2 7e-20 71.8 4.7 2.4 1 1 1 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 AMD19567.1 - 6.5e-11 42.1 1.3 2e-09 37.3 0.1 2.5 2 0 0 2 2 2 2 Surp module Sec10 PF07393.11 AMD19568.1 - 2.3e-42 145.3 10.9 2e-41 142.2 10.9 2.3 1 1 0 1 1 1 1 Exocyst complex component Sec10 TMEM213 PF15192.6 AMD19568.1 - 0.11 12.4 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 TMEM213 family Homeobox_KN PF05920.11 AMD19570.1 - 1e-08 34.9 0.5 2.7e-08 33.6 0.5 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 AMD19570.1 - 3.1e-06 26.9 0.7 3.1e-06 26.9 0.7 2.4 3 0 0 3 3 3 1 Homeodomain Homez PF11569.8 AMD19570.1 - 0.00024 20.5 0.0 0.00056 19.3 0.0 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez GvpG PF05120.12 AMD19570.1 - 0.065 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Gas vesicle protein G UPF0154 PF03672.13 AMD19570.1 - 0.066 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) HTH_28 PF13518.6 AMD19570.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain MATalpha_HMGbox PF04769.12 AMD19571.1 - 5.2e-16 58.6 0.2 5.2e-16 58.6 0.2 1.6 2 0 0 2 2 2 1 Mating-type protein MAT alpha 1 HMG-box SUI1 PF01253.22 AMD19572.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AMD19572.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) tRNA-synt_1e PF01406.19 AMD19573.1 - 4.2e-140 466.3 0.9 7.4e-140 465.5 0.9 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 AMD19573.1 - 1.4e-08 33.9 1.5 3.2e-05 22.9 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AMD19573.1 - 8e-06 24.4 0.0 2.9e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 AMD19573.1 - 0.0053 15.7 2.0 0.0075 15.2 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1f PF01921.18 AMD19573.1 - 0.027 13.4 0.4 0.18 10.7 0.1 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (K) DUF501 PF04417.12 AMD19573.1 - 0.16 11.7 1.1 0.48 10.2 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF501) DnaJ PF00226.31 AMD19574.1 - 4.1e-18 65.3 0.1 6.4e-18 64.6 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 AMD19574.1 - 3.4e-17 61.9 3.1 5.7e-17 61.2 3.1 1.4 1 0 0 1 1 1 1 CSL zinc finger RNA_pol_I_A49 PF06870.12 AMD19575.1 - 1.6e-119 399.2 0.4 1.9e-119 399.0 0.4 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Zwint PF15556.6 AMD19575.1 - 0.034 13.7 0.5 0.12 11.8 0.0 2.1 2 1 1 3 3 3 0 ZW10 interactor DUF5361 PF17318.2 AMD19575.1 - 0.049 13.8 0.0 0.23 11.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5361) AAA_23 PF13476.6 AMD19576.1 - 2.2e-37 129.5 0.2 2.2e-37 129.5 0.2 8.3 2 1 3 5 5 3 1 AAA domain SMC_N PF02463.19 AMD19576.1 - 4.3e-17 62.3 17.6 6.6e-09 35.5 6.2 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain Rad50_zn_hook PF04423.14 AMD19576.1 - 2.9e-15 55.8 3.6 2.9e-15 55.8 3.6 7.2 7 0 0 7 7 6 1 Rad50 zinc hook motif AAA_15 PF13175.6 AMD19576.1 - 4.1e-08 33.3 7.4 4.1e-08 33.3 7.4 4.8 1 1 3 4 4 2 2 AAA ATPase domain AAA_21 PF13304.6 AMD19576.1 - 2.2e-07 31.0 1.3 0.00023 21.1 0.1 4.9 4 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 AMD19576.1 - 1.1e-05 25.5 0.0 3.2e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Laminin_II PF06009.12 AMD19576.1 - 2e-05 24.6 4.5 2e-05 24.6 4.5 10.2 4 2 7 13 13 13 4 Laminin Domain II AAA_13 PF13166.6 AMD19576.1 - 0.00045 19.0 120.9 0.0074 15.0 0.0 7.2 3 1 4 7 7 6 4 AAA domain Spc7 PF08317.11 AMD19576.1 - 0.0014 17.6 6.5 0.0014 17.6 6.5 8.9 1 1 5 9 9 8 3 Spc7 kinetochore protein ERM PF00769.19 AMD19576.1 - 0.0024 17.8 12.7 0.0024 17.8 12.7 6.4 1 1 3 5 5 3 1 Ezrin/radixin/moesin family AAA_29 PF13555.6 AMD19576.1 - 0.0042 16.8 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tropomyosin_1 PF12718.7 AMD19576.1 - 0.006 16.7 12.6 0.006 16.7 12.6 8.4 4 3 3 8 8 6 1 Tropomyosin like ABC_tran PF00005.27 AMD19576.1 - 0.018 15.6 0.0 0.018 15.6 0.0 7.9 4 3 0 5 5 3 0 ABC transporter AAA_16 PF13191.6 AMD19576.1 - 0.049 14.0 0.0 0.049 14.0 0.0 4.3 5 3 0 5 5 4 0 AAA ATPase domain ArAE_2 PF10334.9 AMD19576.1 - 0.11 12.4 0.1 0.11 12.4 0.1 4.2 4 1 0 4 4 4 0 Aromatic acid exporter family member 2 NPV_P10 PF05531.12 AMD19576.1 - 0.21 12.1 48.3 0.046 14.2 0.7 9.8 6 3 2 8 8 8 0 Nucleopolyhedrovirus P10 protein AAA_25 PF13481.6 AMD19576.1 - 0.27 10.8 2.4 4.3 6.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 AMD19576.1 - 3.9 7.8 10.7 0.83 9.9 0.0 4.7 4 1 0 4 4 4 0 AAA domain RRM_1 PF00076.22 AMD19577.1 - 1.9e-07 30.8 0.0 3.9e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 AMD19577.1 - 6.2e-05 23.7 0.0 0.00023 21.9 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_7 PF16367.5 AMD19577.1 - 0.0017 18.4 0.0 0.015 15.4 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif RNA_bind PF08675.11 AMD19577.1 - 0.02 14.9 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA binding domain CTK3 PF12243.8 AMD19577.1 - 0.027 14.5 0.1 0.06 13.3 0.1 1.5 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 Presenilin PF01080.17 AMD19577.1 - 3 6.5 9.1 4.5 5.9 9.1 1.2 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 AMD19577.1 - 3.6 5.7 19.1 0.005 15.2 6.2 1.9 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 AMD19577.1 - 9.1 6.3 6.8 16 5.5 6.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MRP-L46 PF11788.8 AMD19578.1 - 3.7e-36 124.5 0.1 6e-36 123.8 0.1 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 WD40 PF00400.32 AMD19579.1 - 1.9e-07 31.6 8.7 0.00059 20.6 0.4 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19579.1 - 5.6e-06 26.6 0.4 0.046 14.0 0.1 4.4 1 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SKA1 PF07160.12 AMD19579.1 - 0.0078 16.1 0.1 0.013 15.4 0.1 1.3 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 Hira PF07569.11 AMD19579.1 - 0.013 15.2 0.0 6.5 6.4 0.0 2.4 2 0 0 2 2 2 0 TUP1-like enhancer of split HSP20 PF00011.21 AMD19580.1 - 2.9e-20 72.3 0.1 3.6e-20 72.0 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AMD19580.1 - 4.6e-06 26.1 0.0 7.9e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA RTC4 PF14474.6 AMD19581.1 - 8.2e-32 109.9 0.1 1.7e-31 108.9 0.1 1.6 1 0 0 1 1 1 1 RTC4-like domain DUF2250 PF10007.9 AMD19581.1 - 0.37 10.9 2.3 4.8 7.4 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) DUF5341 PF17276.2 AMD19582.1 - 0.033 14.4 0.1 0.064 13.4 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5341) CRAL_TRIO_2 PF13716.6 AMD19583.1 - 1.5e-29 102.9 1.6 1.5e-29 102.9 1.6 1.8 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 AMD19583.1 - 1.8e-09 37.6 0.1 7e-09 35.7 0.1 1.9 1 1 0 1 1 1 1 RhoGAP domain RasGEF PF00617.19 AMD19584.1 - 4.6e-39 134.4 0.3 1.4e-38 132.9 0.3 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 AMD19584.1 - 9.5e-12 45.1 2.4 4.8e-11 42.8 0.4 3.2 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.28 AMD19584.1 - 0.00049 19.6 0.1 0.0012 18.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AMD19584.1 - 0.017 15.0 0.1 0.13 12.1 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain Nt_Gln_amidase PF09764.9 AMD19584.1 - 0.048 13.3 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 N-terminal glutamine amidase SPX PF03105.19 AMD19585.1 - 1.5e-47 163.3 14.8 8.6e-34 118.1 8.0 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 AMD19585.1 - 3.7e-25 88.9 50.3 5e-25 88.5 50.3 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AMD19585.1 - 2.2e-24 86.2 75.0 2.7e-22 79.3 47.7 2.1 1 1 1 2 2 2 2 Citrate transporter Muted PF14942.6 AMD19585.1 - 0.11 12.8 1.1 0.26 11.6 1.1 1.6 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF4635 PF15466.6 AMD19585.1 - 0.23 11.0 0.6 20 4.7 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) UCH PF00443.29 AMD19586.1 - 3.5e-77 259.4 3.1 6.3e-77 258.5 3.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD19586.1 - 1.1e-12 48.2 5.5 1.5e-05 24.7 1.1 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 AMD19586.1 - 2.8e-05 24.6 0.3 0.00018 22.0 0.3 2.5 1 0 0 1 1 1 1 DUSP domain ubiquitin PF00240.23 AMD19586.1 - 0.038 13.7 0.0 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family CW_binding_1 PF01473.20 AMD19586.1 - 0.23 11.9 2.5 0.76 10.2 2.5 2.0 1 0 0 1 1 1 0 Putative cell wall binding repeat PfkB PF00294.24 AMD19587.1 - 2.7e-46 158.3 1.0 1.2e-45 156.2 1.0 1.8 1 1 0 1 1 1 1 pfkB family carbohydrate kinase MafB19-deam PF14437.6 AMD19587.1 - 0.039 13.7 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 MafB19-like deaminase RNase_PH PF01138.21 AMD19588.1 - 3.7e-20 72.8 1.3 3.6e-18 66.3 1.1 2.9 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 ELO PF01151.18 AMD19589.1 - 3e-57 194.0 25.5 3.7e-57 193.7 25.5 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family TMEM237 PF15383.6 AMD19589.1 - 3 6.9 9.7 5.2 6.1 9.7 1.3 1 0 0 1 1 1 0 Transmembrane protein 237 Myb_DNA-binding PF00249.31 AMD19590.1 - 9.5e-16 57.7 0.0 3.9e-07 30.1 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD19590.1 - 7.3e-06 26.2 4.6 0.034 14.4 0.2 3.9 4 0 0 4 4 4 2 Myb-like DNA-binding domain Xan_ur_permease PF00860.20 AMD19591.1 - 2.2e-62 211.0 30.0 3.2e-62 210.5 30.0 1.2 1 0 0 1 1 1 1 Permease family Phage_holin_2_3 PF16080.5 AMD19591.1 - 4.8 7.0 6.1 10 6.0 0.1 3.8 3 0 0 3 3 3 0 Bacteriophage holin family HP1 WD40 PF00400.32 AMD19593.1 - 1.1e-08 35.5 13.2 0.0073 17.1 0.3 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.8 AMD19593.1 - 2.2e-05 23.4 0.1 0.00037 19.3 0.1 2.0 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PQQ_3 PF13570.6 AMD19593.1 - 0.00052 20.4 0.6 0.053 14.0 0.0 3.7 4 0 0 4 4 4 1 PQQ-like domain PQQ PF01011.21 AMD19593.1 - 0.0013 18.6 0.2 0.0059 16.5 0.2 2.2 1 0 0 1 1 1 1 PQQ enzyme repeat SMI1_KNR4 PF09346.10 AMD19593.1 - 0.0059 17.0 0.4 0.047 14.1 0.0 2.6 3 0 0 3 3 3 1 SMI1 / KNR4 family (SUKH-1) cpYpsA PF12694.7 AMD19593.1 - 0.081 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Circularly permutated YpsA SLOG family SUKH_6 PF14568.6 AMD19593.1 - 0.1 13.0 1.4 2.5 8.5 0.0 2.6 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall Kelch_5 PF13854.6 AMD19593.1 - 0.23 11.5 1.6 13 5.9 0.0 3.0 3 0 0 3 3 3 0 Kelch motif NMT_C PF02799.15 AMD19594.1 - 4.7e-76 255.0 0.5 8.6e-76 254.1 0.2 1.5 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 AMD19594.1 - 1.4e-73 246.0 0.1 3.1e-73 244.9 0.0 1.7 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 AMD19594.1 - 0.0033 17.5 0.0 0.022 14.8 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF1576 PF07613.11 AMD19594.1 - 0.051 13.1 0.0 6.8 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1576) DUF3492 PF11997.8 AMD19595.1 - 0.07 12.8 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Apt1 PF10351.9 AMD19595.1 - 0.48 9.2 9.3 0.67 8.7 9.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain EBP50_C PF09007.11 AMD19595.1 - 1.9 9.5 12.5 1.1 10.2 8.4 2.3 2 0 0 2 2 2 0 EBP50, C-terminal Zip PF02535.22 AMD19595.1 - 2.9 7.0 5.6 2.8 7.1 3.5 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter PRELI PF04707.14 AMD19596.1 - 1.3e-41 142.1 0.0 1.5e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family GATase_2 PF00310.21 AMD19597.1 - 2.7e-165 550.2 0.0 4.1e-165 549.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 AMD19597.1 - 1.5e-154 514.6 0.1 4.3e-154 513.1 0.0 1.8 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 AMD19597.1 - 1.5e-113 378.9 0.0 2.4e-110 368.4 0.0 2.4 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 AMD19597.1 - 2.4e-71 239.3 1.5 4.7e-71 238.3 1.5 1.5 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.6 AMD19597.1 - 5.7e-22 77.6 0.1 1e-21 76.8 0.1 1.4 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 AMD19597.1 - 1.5e-21 76.9 0.1 2.3e-20 73.0 0.1 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AMD19597.1 - 1.1e-08 35.2 0.0 2.9e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 AMD19597.1 - 4.3e-08 33.6 0.8 4.3e-06 27.2 0.0 3.4 3 1 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 AMD19597.1 - 3.9e-06 26.4 0.0 1.1e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 AMD19597.1 - 1.9e-05 23.6 1.1 3.9e-05 22.5 0.0 2.0 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_3 PF13738.6 AMD19597.1 - 2.9e-05 23.5 0.1 0.012 14.9 0.0 2.6 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AMD19597.1 - 0.00016 20.9 0.0 0.0003 20.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 AMD19597.1 - 0.00024 20.8 0.1 0.0007 19.3 0.1 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 AMD19597.1 - 0.00034 20.1 0.3 0.00076 18.9 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 AMD19597.1 - 0.0025 17.1 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 AMD19597.1 - 0.0042 16.4 0.0 0.014 14.6 0.0 1.9 2 0 0 2 2 2 1 Thi4 family NAD_Gly3P_dh_N PF01210.23 AMD19597.1 - 0.0092 16.0 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 AMD19597.1 - 0.01 14.9 2.4 0.045 12.8 0.0 2.8 3 0 0 3 3 3 0 Glucose inhibited division protein A FMN_dh PF01070.18 AMD19597.1 - 0.037 13.1 0.2 0.23 10.4 0.7 2.0 2 0 0 2 2 2 0 FMN-dependent dehydrogenase NAD_binding_7 PF13241.6 AMD19597.1 - 0.043 14.2 0.6 5.2 7.6 0.0 2.8 2 0 0 2 2 2 0 Putative NAD(P)-binding GATase_6 PF13522.6 AMD19597.1 - 0.059 13.6 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Glutamine amidotransferase domain 2-Hacid_dh_C PF02826.19 AMD19597.1 - 0.059 12.7 0.0 2.4 7.5 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 AMD19597.1 - 0.092 12.7 0.0 0.47 10.4 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 AMD19597.1 - 0.19 10.8 0.0 0.35 9.9 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein DUF3602 PF12223.8 AMD19598.1 - 2.5e-20 72.9 5.9 1.1e-09 38.8 0.0 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 AMD19598.1 - 0.0055 16.3 0.3 3.1 7.4 0.0 3.0 3 0 0 3 3 3 2 GTP1/OBG eIF3_subunit PF08597.10 AMD19599.1 - 5.4e-47 160.7 30.5 3.4e-46 158.1 30.5 1.8 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit TonB_N PF16031.5 AMD19599.1 - 0.89 10.1 10.5 0.094 13.2 5.5 1.9 2 0 0 2 2 2 0 TonB polyproline region R3H-assoc PF13902.6 AMD19599.1 - 4.9 7.6 8.5 0.2 12.1 1.1 2.3 3 0 0 3 3 3 0 R3H-associated N-terminal domain Peroxin-13_N PF04088.13 AMD19600.1 - 1e-47 162.1 2.4 1.4e-47 161.6 2.4 1.1 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 AMD19600.1 - 5e-09 35.6 0.0 8.8e-09 34.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AMD19600.1 - 4.7e-07 29.4 0.0 9.5e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 AMD19600.1 - 1.4e-06 28.0 0.0 2.4e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 AMD19600.1 - 0.00045 20.4 0.0 0.00086 19.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain MMR1 PF08505.10 AMD19601.1 - 2.3e-06 28.1 9.7 2.3e-06 28.1 9.7 3.3 2 1 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein MCC-bdg_PDZ PF10506.9 AMD19601.1 - 0.36 10.9 4.0 1.9 8.5 0.8 2.4 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Nop25 PF09805.9 AMD19601.1 - 0.38 11.2 4.2 1.1 9.8 4.2 1.8 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) PALP PF00291.25 AMD19602.1 - 1.3e-76 257.9 0.0 1.6e-76 257.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 AMD19602.1 - 1.2e-40 137.2 0.0 4.8e-23 80.7 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Propep_M14 PF02244.16 AMD19602.1 - 0.065 13.6 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Carboxypeptidase activation peptide tRNA-synt_2b PF00587.25 AMD19603.1 - 7.1e-34 117.3 0.0 1.2e-33 116.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Sec61_beta PF03911.16 AMD19604.1 - 1.4e-18 66.6 1.9 1.7e-18 66.4 1.9 1.1 1 0 0 1 1 1 1 Sec61beta family Cas_Csx9 PF09658.10 AMD19604.1 - 0.027 13.7 0.0 0.03 13.5 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csx9) S36_mt PF10937.8 AMD19605.1 - 2e-23 84.1 0.0 2.6e-23 83.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial PDEase_II PF02112.15 AMD19606.1 - 6.7e-63 212.8 0.9 4.6e-61 206.8 2.1 2.2 1 1 1 2 2 2 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 AMD19606.1 - 1.2e-05 25.0 0.0 3.2e-05 23.5 0.0 1.8 2 1 0 2 2 2 1 Beta-lactamase superfamily domain DUF5483 PF17581.2 AMD19606.1 - 0.087 11.7 0.6 0.12 11.3 0.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5483) Lactamase_B PF00753.27 AMD19606.1 - 0.12 12.4 1.6 0.26 11.3 1.6 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Proteasome PF00227.26 AMD19607.1 - 1.3e-24 86.7 0.1 1.6e-24 86.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Adap_comp_sub PF00928.21 AMD19608.1 - 3.2e-13 49.7 0.6 4.9e-13 49.1 0.6 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AMD19608.1 - 9.6e-06 25.6 0.5 2.3e-05 24.3 0.5 1.7 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribonuc_red_lgC PF02867.15 AMD19610.1 - 5.3e-178 592.8 0.0 6.4e-178 592.5 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AMD19610.1 - 2.3e-24 85.2 0.0 5.4e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AMD19610.1 - 0.0016 18.9 0.0 0.0045 17.5 0.0 1.8 1 0 0 1 1 1 1 ATP cone domain APG6 PF04111.12 AMD19611.1 - 8e-61 205.1 0.1 1.4e-60 204.3 0.1 1.4 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 AMD19611.1 - 4.1e-23 82.4 20.7 4.1e-23 82.4 20.7 2.4 2 1 1 3 3 3 1 Apg6 coiled-coil region NHR2 PF08788.11 AMD19611.1 - 0.0051 16.6 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 NHR2 domain like V_ATPase_I PF01496.19 AMD19611.1 - 0.13 10.2 7.1 0.2 9.6 7.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cytochrom_NNT PF03264.14 AMD19611.1 - 0.15 11.8 0.0 0.15 11.8 0.0 2.6 3 1 0 3 3 3 0 NapC/NirT cytochrome c family, N-terminal region ORC_WH_C PF18137.1 AMD19611.1 - 0.19 11.8 7.1 0.2 11.7 5.4 1.8 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal MMR_HSR1 PF01926.23 AMD19612.1 - 5.3e-10 39.4 0.0 2.1e-09 37.5 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD19612.1 - 0.00022 21.1 0.0 0.00059 19.8 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 AMD19612.1 - 0.0023 18.0 0.0 0.0092 16.0 0.0 1.7 1 1 0 1 1 1 1 Dynamin family GTP_EFTU PF00009.27 AMD19612.1 - 0.0029 17.1 0.0 0.15 11.6 0.0 2.6 1 1 2 3 3 3 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 AMD19612.1 - 0.0073 15.8 0.2 0.043 13.4 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B PhnJ PF06007.11 AMD19612.1 - 0.015 14.3 0.0 0.033 13.2 0.0 1.5 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnJ Noc2 PF03715.13 AMD19613.1 - 1.1e-123 412.3 4.0 1.1e-123 412.3 4.0 2.7 3 0 0 3 3 3 2 Noc2p family pKID PF02173.17 AMD19613.1 - 0.025 14.1 0.0 0.071 12.6 0.0 1.8 1 0 0 1 1 1 0 pKID domain Mei5 PF10376.9 AMD19614.1 - 7.9e-21 74.9 15.3 9.7e-21 74.6 15.3 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein DUF3479 PF11965.8 AMD19614.1 - 0.024 14.8 0.5 0.024 14.8 0.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3479) Exonuc_VII_S PF02609.16 AMD19614.1 - 0.079 13.0 1.0 0.079 13.0 1.0 3.4 3 1 1 4 4 4 0 Exonuclease VII small subunit HTH_Tnp_Tc3_1 PF11427.8 AMD19614.1 - 0.2 11.5 0.5 14 5.6 0.1 2.6 2 0 0 2 2 2 0 Tc3 transposase SprA-related PF12118.8 AMD19614.1 - 3.3 6.8 7.5 6.7 5.7 7.5 1.4 1 0 0 1 1 1 0 SprA-related family DUF1168 PF06658.12 AMD19614.1 - 4.7 7.0 11.1 0.76 9.6 7.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) RNA_pol_Rpb2_6 PF00562.28 AMD19615.1 - 1.8e-125 419.1 0.2 1.8e-125 419.1 0.2 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AMD19615.1 - 3e-58 196.7 2.3 3.1e-58 196.6 1.2 1.6 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AMD19615.1 - 3e-41 141.2 4.6 9.3e-41 139.5 4.3 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 AMD19615.1 - 6.5e-33 113.0 0.1 2.2e-32 111.3 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 AMD19615.1 - 1e-26 93.0 0.2 3.9e-26 91.1 0.2 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 AMD19615.1 - 2.3e-18 66.1 0.0 5.9e-18 64.8 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 AMD19615.1 - 2.2e-11 44.1 0.2 9.4e-11 42.1 0.2 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Tfb2 PF03849.14 AMD19616.1 - 2e-139 464.5 0.2 2.8e-139 464.1 0.2 1.2 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 AMD19616.1 - 8.8e-23 80.5 0.9 1.8e-22 79.5 0.9 1.5 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 AMD19616.1 - 7.7e-06 26.1 0.0 1.6e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD19617.1 - 6.2e-49 166.1 0.0 1.5e-48 164.9 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19617.1 - 2.5e-31 108.3 0.0 6.3e-31 107.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD19617.1 - 0.0052 16.8 0.0 0.0098 15.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AMD19617.1 - 0.009 15.2 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 AMD19617.1 - 0.17 11.2 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Mit_ribos_Mrp51 PF11709.8 AMD19618.1 - 1.2e-56 192.9 2.1 9.9e-35 120.8 0.3 2.5 1 1 1 2 2 2 2 Mitochondrial ribosomal protein subunit IGPD PF00475.18 AMD19619.1 - 1.8e-61 206.7 0.4 3.1e-61 205.9 0.4 1.3 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase SpoU_methylase PF00588.19 AMD19620.1 - 2.7e-28 98.9 0.0 7e-28 97.6 0.0 1.7 2 0 0 2 2 2 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 AMD19620.1 - 5.6e-16 58.6 0.0 1.6e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding NUDIX PF00293.28 AMD19621.1 - 4.7e-30 104.3 0.0 7.8e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain FapA PF03961.13 AMD19622.1 - 2.4e-05 23.2 14.3 2.4e-05 23.2 14.3 3.9 2 1 2 4 4 4 1 Flagellar Assembly Protein A Baculo_PEP_C PF04513.12 AMD19622.1 - 0.058 13.4 18.9 1.4 9.0 3.7 4.7 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DELLA PF12041.8 AMD19622.1 - 1.9 8.4 11.6 2.2 8.2 0.1 4.1 3 1 2 5 5 5 0 Transcriptional regulator DELLA protein N terminal HsbA PF12296.8 AMD19622.1 - 2.8 8.4 8.5 6.3 7.3 0.5 3.8 2 1 2 4 4 4 0 Hydrophobic surface binding protein A IclR PF01614.18 AMD19622.1 - 3.2 7.6 7.4 1.4 8.7 0.2 3.0 2 0 0 2 2 2 0 Bacterial transcriptional regulator MtrG PF04210.13 AMD19622.1 - 5.6 6.9 12.8 2.1 8.3 0.9 4.4 3 2 1 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G Peptidase_C14 PF00656.22 AMD19623.1 - 9.7e-63 212.4 0.0 1.5e-62 211.8 0.0 1.3 1 0 0 1 1 1 1 Caspase domain Hist_deacetyl PF00850.19 AMD19624.1 - 1.5e-52 179.0 0.1 2.7e-52 178.2 0.1 1.4 1 0 0 1 1 1 1 Histone deacetylase domain LIAS_N PF16881.5 AMD19625.1 - 1.9e-22 79.7 0.2 8.4e-22 77.6 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 AMD19625.1 - 6e-14 52.8 0.0 1.1e-13 51.9 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Spore_GerAC PF05504.11 AMD19625.1 - 0.04 14.1 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal RhoGAP PF00620.27 AMD19626.1 - 5.5e-35 120.4 0.0 1.4e-34 119.2 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 AMD19626.1 - 6.9e-10 39.4 0.2 2.1e-09 37.9 0.2 1.9 1 0 0 1 1 1 1 PH domain PX PF00787.24 AMD19626.1 - 1.1e-05 25.4 0.0 2.8e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 PX domain DUF1708 PF08101.11 AMD19626.1 - 0.0023 17.1 0.1 0.007 15.6 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1708) Spc42p PF11544.8 AMD19626.1 - 0.065 13.2 0.1 0.22 11.6 0.1 1.9 1 0 0 1 1 1 0 Spindle pole body component Spc42p Fungal_TACC PF12709.7 AMD19627.1 - 4.3e-32 110.4 15.2 4.3e-32 110.4 15.2 9.5 5 2 5 11 11 11 2 Fungal Transforming acidic coiled-coil (TACC) proteins HAP1_N PF04849.13 AMD19627.1 - 0.00055 19.2 27.7 0.00055 19.2 27.7 6.1 2 2 2 4 4 4 1 HAP1 N-terminal conserved region ATG16 PF08614.11 AMD19627.1 - 0.0011 19.2 25.7 0.0011 19.2 25.7 5.3 1 1 2 4 4 4 1 Autophagy protein 16 (ATG16) ADIP PF11559.8 AMD19627.1 - 0.0019 18.3 13.3 0.0019 18.3 13.3 7.6 3 2 5 8 8 8 3 Afadin- and alpha -actinin-Binding SlyX PF04102.12 AMD19627.1 - 0.0076 16.8 73.1 0.29 11.8 5.1 9.7 2 2 7 10 10 10 3 SlyX MscS_porin PF12795.7 AMD19627.1 - 0.0095 15.5 19.4 0.0095 15.5 19.4 5.5 2 2 2 4 4 4 1 Mechanosensitive ion channel porin domain DUF4407 PF14362.6 AMD19627.1 - 0.013 14.9 77.8 0.057 12.8 21.6 5.3 1 1 4 5 5 5 0 Domain of unknown function (DUF4407) IGR PF09597.10 AMD19627.1 - 0.036 14.2 0.1 0.23 11.6 0.1 2.4 1 0 0 1 1 1 0 IGR protein motif KASH_CCD PF14662.6 AMD19627.1 - 0.11 12.3 107.4 0.057 13.2 19.5 6.9 2 2 5 7 7 7 0 Coiled-coil region of CCDC155 or KASH Pox_A_type_inc PF04508.12 AMD19627.1 - 0.24 11.3 11.5 17 5.5 0.0 6.1 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat Taxilin PF09728.9 AMD19627.1 - 0.42 9.7 97.5 2.9 7.0 58.0 3.5 1 1 1 2 2 2 0 Myosin-like coiled-coil protein FAM76 PF16046.5 AMD19627.1 - 1.4 8.2 80.3 0.039 13.3 16.2 4.7 1 1 3 4 4 4 0 FAM76 protein Filament PF00038.21 AMD19627.1 - 1.5 8.3 95.5 0.42 10.2 10.9 6.0 1 1 4 5 5 5 0 Intermediate filament protein MAD PF05557.13 AMD19627.1 - 1.8 6.8 98.8 1.4 7.2 44.8 3.2 1 1 2 3 3 3 0 Mitotic checkpoint protein Spc7 PF08317.11 AMD19627.1 - 2 7.2 107.9 1.5 7.7 26.5 5.5 1 1 3 5 5 5 0 Spc7 kinetochore protein Fez1 PF06818.15 AMD19627.1 - 2.4 8.6 93.9 0.62 10.5 22.8 5.2 1 1 3 4 4 3 0 Fez1 CENP-F_leu_zip PF10473.9 AMD19627.1 - 2.6 8.1 113.4 0.087 12.9 10.2 6.1 2 2 3 5 5 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CEP63 PF17045.5 AMD19627.1 - 5.2 6.9 94.1 1.3 8.8 17.8 4.1 1 1 3 4 4 4 0 Centrosomal protein of 63 kDa TFIIA PF03153.13 AMD19628.1 - 1.9e-51 176.4 20.7 8.8e-29 101.7 14.9 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Nanovirus_coat PF04660.12 AMD19628.1 - 0.073 13.1 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Nanovirus coat protein DUF1476 PF07345.11 AMD19628.1 - 0.13 12.6 3.0 0.26 11.7 0.1 2.2 2 0 0 2 2 2 0 ATPase inhibitor subunit zeta PEX11 PF05648.14 AMD19629.1 - 5.5e-07 29.3 3.9 1.1e-05 25.0 3.9 2.4 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) SKG6 PF08693.10 AMD19630.1 - 5.3e-06 25.7 1.6 5.3e-06 25.7 1.6 1.5 2 0 0 2 2 2 1 Transmembrane alpha-helix domain PMP1_2 PF08114.11 AMD19630.1 - 0.0029 17.3 0.2 0.0061 16.3 0.2 1.5 1 0 0 1 1 1 1 ATPase proteolipid family Alpha_GJ PF03229.13 AMD19630.1 - 0.0071 16.9 0.2 0.0098 16.4 0.2 1.2 1 0 0 1 1 1 1 Alphavirus glycoprotein J DUF3827 PF12877.7 AMD19630.1 - 0.25 9.7 0.0 0.3 9.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Arginase PF00491.21 AMD19631.1 - 2.4e-75 253.6 0.0 2.8e-75 253.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family MoCF_biosynth PF00994.24 AMD19631.1 - 0.099 12.3 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 Probable molybdopterin binding domain GDPD PF03009.17 AMD19633.1 - 1.4e-76 257.6 0.0 2.7e-76 256.7 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 AMD19633.1 - 6.6e-26 90.7 0.2 4.6e-12 46.4 0.0 4.6 3 1 3 6 6 6 4 Ankyrin repeats (3 copies) SPX PF03105.19 AMD19633.1 - 3.2e-21 76.7 26.3 1.2e-12 48.4 0.6 4.4 2 1 2 4 4 4 3 SPX domain Ank_4 PF13637.6 AMD19633.1 - 3e-20 72.3 0.0 8e-06 26.3 0.0 4.4 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD19633.1 - 2.7e-17 61.1 1.0 0.068 13.8 0.0 7.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 AMD19633.1 - 1.7e-12 47.3 0.0 0.1 13.0 0.0 5.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 AMD19633.1 - 3.5e-11 43.0 2.9 0.54 10.8 0.0 6.6 7 0 0 7 7 7 4 Ankyrin repeat TLC PF03219.14 AMD19633.1 - 0.13 10.9 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 TLC ATP/ADP transporter ABC1 PF03109.16 AMD19634.1 - 8.6e-19 67.9 0.0 2.3e-18 66.5 0.0 1.7 1 0 0 1 1 1 1 ABC1 family HEPN_Swt1 PF18731.1 AMD19634.1 - 0.11 12.8 0.0 9.3 6.6 0.0 2.8 2 0 0 2 2 2 0 Swt1-like HEPN Arf PF00025.21 AMD19635.1 - 2.1e-76 255.3 0.1 2.4e-76 255.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 AMD19635.1 - 1.4e-15 57.5 0.1 1.9e-15 57.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AMD19635.1 - 6.9e-11 42.0 0.0 7.9e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 AMD19635.1 - 1e-10 41.4 0.0 1.1e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AMD19635.1 - 7.6e-10 38.5 0.0 9.5e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 AMD19635.1 - 9.2e-10 38.2 0.3 4.6e-06 26.0 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 AMD19635.1 - 8.5e-05 22.6 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 AMD19635.1 - 0.00026 21.5 0.2 0.0011 19.5 0.2 1.8 1 1 0 1 1 1 1 ABC transporter GTP_EFTU PF00009.27 AMD19635.1 - 0.00033 20.2 0.1 0.003 17.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 AMD19635.1 - 0.0028 16.7 0.5 0.14 11.1 0.2 2.7 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 AMD19635.1 - 0.067 13.7 0.1 0.11 13.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AMD19635.1 - 0.14 12.0 0.1 8.6 6.2 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 AMD19635.1 - 0.14 11.7 0.6 8.9 5.9 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 AMD19635.1 - 0.15 11.7 0.5 0.67 9.5 0.1 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PDH PF02153.17 AMD19637.1 - 7e-09 35.1 0.0 9.1e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase ApbA PF02558.16 AMD19637.1 - 5.2e-06 26.2 0.0 1.3e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 AMD19637.1 - 1.1e-05 25.6 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 AMD19637.1 - 5.3e-05 22.6 0.0 0.00011 21.6 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AMD19637.1 - 6.6e-05 23.4 0.0 0.00016 22.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 AMD19637.1 - 0.003 17.8 0.0 0.01 16.1 0.0 1.9 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.18 AMD19637.1 - 0.0053 16.7 0.0 0.01 15.7 0.0 1.5 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AMD19637.1 - 0.0061 16.6 0.0 0.017 15.2 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 AMD19637.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 AMD19637.1 - 0.025 14.1 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ureidogly_lyase PF04115.12 AMD19638.1 - 7.3e-29 100.9 0.0 8.8e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 Ureidoglycolate lyase DUF3545 PF12065.8 AMD19639.1 - 0.077 13.0 0.4 2.5 8.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3545) Rpp20 PF12328.8 AMD19640.1 - 4.1e-28 98.0 8.7 2.2e-26 92.5 8.7 2.0 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 AMD19640.1 - 4.7e-10 39.1 0.4 7.8e-10 38.4 0.4 1.4 1 0 0 1 1 1 1 Alba BAAT_C PF08840.11 AMD19640.1 - 0.061 13.2 0.0 0.074 13.0 0.0 1.1 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Pex24p PF06398.11 AMD19641.1 - 3.7e-36 124.9 20.0 4.4e-36 124.6 20.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin AGP PF06376.12 AMD19641.1 - 0.069 13.0 0.4 0.14 12.0 0.4 1.5 1 0 0 1 1 1 0 Arabinogalactan peptide Oxidored-like PF09791.9 AMD19642.1 - 1.2e-22 79.3 2.1 2.3e-22 78.4 2.1 1.5 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal HSP70 PF00012.20 AMD19643.1 - 5.8e-182 606.0 6.1 5.8e-182 606.0 6.1 2.1 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 AMD19643.1 - 5.3e-10 38.6 0.2 1.1e-09 37.6 0.2 1.4 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 AMD19643.1 - 0.011 16.2 0.1 0.011 16.2 0.1 3.4 3 2 0 3 3 3 0 Cell division protein FtsA NPL4 PF05021.15 AMD19644.1 - 2.2e-133 444.4 0.1 2.8e-133 444.0 0.1 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 AMD19644.1 - 2.7e-67 225.4 0.5 4.6e-67 224.7 0.5 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 AMD19644.1 - 1.7e-07 31.6 0.0 5e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.9 AMD19645.1 - 4.5e-68 228.4 3.6 5.2e-68 228.2 3.6 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 MKLP1_Arf_bdg PF16540.5 AMD19645.1 - 0.11 12.6 0.2 17 5.5 0.0 2.1 2 0 0 2 2 2 0 Arf6-interacting domain of mitotic kinesin-like protein 1 GYF PF02213.16 AMD19646.1 - 1.2e-11 44.0 0.6 3.3e-11 42.7 0.6 1.8 1 0 0 1 1 1 1 GYF domain UMP1 PF05348.11 AMD19647.1 - 2.7e-36 124.4 0.1 3.1e-36 124.2 0.1 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 IIGP PF05049.13 AMD19647.1 - 0.13 11.3 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) WD40 PF00400.32 AMD19648.1 - 1.1e-26 92.5 11.1 1.1e-05 26.1 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19648.1 - 1.1e-18 67.3 0.1 4.8e-06 26.8 0.0 5.3 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD19648.1 - 5.8e-05 21.9 0.4 0.11 11.1 0.0 3.5 2 1 2 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 AMD19648.1 - 0.00023 21.1 0.0 0.014 15.3 0.0 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 AMD19648.1 - 0.0012 18.0 0.0 0.0049 16.0 0.0 1.7 2 0 0 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 AMD19648.1 - 0.022 13.3 0.0 0.13 10.8 0.0 2.1 1 1 0 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 AMD19648.1 - 0.023 13.7 0.1 4.7 6.1 0.0 3.1 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DPPIV_N PF00930.21 AMD19648.1 - 0.14 10.9 0.2 1.6 7.4 0.0 2.2 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region tRNA-synt_2 PF00152.20 AMD19649.1 - 2.5e-100 335.6 0.0 3.4e-100 335.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AMD19649.1 - 5.3e-09 35.9 0.1 1.1e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 AMD19649.1 - 0.0084 16.1 0.2 0.02 14.9 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 AMD19649.1 - 0.091 12.2 0.2 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Pantoate_transf PF02548.15 AMD19650.1 - 6.9e-96 320.6 0.1 8.1e-96 320.4 0.1 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 AMD19650.1 - 0.00087 18.8 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Lactamase_B_2 PF12706.7 AMD19651.1 - 1.2e-29 103.3 0.1 1.9e-29 102.6 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AMD19651.1 - 1e-10 41.8 0.0 1.9e-10 40.9 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain MnmE_helical PF12631.7 AMD19653.1 - 1.4e-39 136.4 0.8 1.8e-39 136.0 0.8 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 AMD19653.1 - 9.8e-32 109.7 0.0 2.3e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 AMD19653.1 - 2e-22 79.4 0.1 4.5e-22 78.3 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD19653.1 - 8.7e-12 44.8 0.1 1.7e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AMD19653.1 - 7.6e-10 38.9 0.5 9.8e-06 25.6 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 AMD19653.1 - 2.5e-07 30.3 1.3 1.9e-06 27.4 1.3 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AMD19653.1 - 7.4e-07 28.9 0.1 9.3e-06 25.3 0.1 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AMD19653.1 - 3.2e-06 27.3 1.0 0.012 15.6 0.1 2.4 1 1 1 2 2 2 2 Dynamin family Ras PF00071.22 AMD19653.1 - 0.00021 20.9 0.7 0.0013 18.4 0.1 2.3 2 1 0 2 2 2 1 Ras family Septin PF00735.18 AMD19653.1 - 0.00046 19.6 1.5 0.0026 17.1 1.0 2.1 1 1 0 2 2 2 1 Septin Roc PF08477.13 AMD19653.1 - 0.0028 17.9 0.0 0.017 15.4 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 AMD19653.1 - 0.01 16.3 0.0 0.035 14.5 0.0 1.9 1 1 1 2 2 2 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 AMD19653.1 - 0.031 14.3 0.1 0.097 12.7 0.1 1.8 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TIR_2 PF13676.6 AMD19653.1 - 0.051 14.2 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 TIR domain CofC PF01983.16 AMD19653.1 - 0.054 12.7 2.8 0.1 11.7 0.2 2.4 3 0 0 3 3 3 0 Guanylyl transferase CofC like G-alpha PF00503.20 AMD19653.1 - 0.065 12.4 1.7 1.4 8.0 0.1 2.3 2 0 0 2 2 2 0 G-protein alpha subunit cobW PF02492.19 AMD19653.1 - 0.13 11.8 2.1 0.78 9.3 0.8 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain BLI1 PF17324.2 AMD19654.1 - 6.5e-24 84.7 6.7 7.5e-24 84.5 6.7 1.0 1 0 0 1 1 1 1 BLOC-1 interactor 1 Adaptin_binding PF10199.9 AMD19654.1 - 0.011 16.3 2.4 0.013 16.1 2.4 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 CENP-Q PF13094.6 AMD19654.1 - 0.037 14.2 7.2 0.033 14.4 6.2 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit BLOC1_2 PF10046.9 AMD19654.1 - 0.056 13.7 4.1 0.15 12.4 4.0 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2347 PF09804.9 AMD19655.1 - 1.5e-72 244.6 0.0 1.9e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 AMD19655.1 - 7.8e-08 32.6 2.7 0.0074 16.4 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4484) SPA PF08616.10 AMD19655.1 - 0.016 15.1 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 Stabilization of polarity axis Glyco_hydro_76 PF03663.14 AMD19656.1 - 8.4e-150 499.3 10.3 9.5e-150 499.2 10.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AMD19656.1 - 0.22 10.6 9.8 0.2 10.7 0.1 2.8 1 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 AMD19657.1 - 1.1e-150 502.2 14.1 1.3e-150 502.1 14.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AMD19657.1 - 0.46 9.5 9.0 0.32 10.0 0.3 2.7 1 1 0 3 3 3 0 Glycosyl Hydrolase Family 88 UQ_con PF00179.26 AMD19658.1 - 3.8e-48 162.7 0.0 4.3e-48 162.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 AMD19658.1 - 0.27 11.5 2.4 0.57 10.5 0.8 2.2 2 1 0 2 2 2 0 RWD domain Copper-fist PF00649.18 AMD19659.1 - 5.6e-20 70.5 2.9 5.6e-20 70.5 2.9 2.2 2 0 0 2 2 2 1 Copper fist DNA binding domain Amino_oxidase PF01593.24 AMD19660.1 - 3.4e-55 188.1 0.0 4.6e-55 187.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AMD19660.1 - 1.9e-10 40.8 0.0 4.2e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 AMD19660.1 - 6.2e-05 22.3 0.9 0.00075 18.7 0.9 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 AMD19660.1 - 9.9e-05 21.7 2.9 0.0043 16.4 0.5 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AMD19660.1 - 0.00023 20.5 0.3 0.00042 19.7 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 AMD19660.1 - 0.0022 17.3 0.2 0.029 13.6 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AMD19660.1 - 0.0067 16.4 0.4 5.5 7.0 0.0 2.6 2 1 0 2 2 2 2 FAD-NAD(P)-binding PepSY_like PF11396.8 AMD19660.1 - 0.01 16.4 0.6 0.55 10.8 0.1 2.5 2 0 0 2 2 2 0 Putative beta-lactamase-inhibitor-like, PepSY-like DAO PF01266.24 AMD19660.1 - 0.011 15.3 0.0 0.078 12.6 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 AMD19660.1 - 0.016 14.2 0.4 0.027 13.5 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 AMD19660.1 - 0.017 14.4 0.1 0.029 13.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 AMD19660.1 - 0.026 13.3 1.0 0.048 12.4 0.4 1.7 2 0 0 2 2 2 0 HI0933-like protein Rota_NSP4 PF01452.16 AMD19660.1 - 0.033 13.9 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 Rotavirus non structural protein Shikimate_DH PF01488.20 AMD19660.1 - 0.049 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 AMD19660.1 - 0.2 11.9 0.1 0.46 10.8 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 AMD19660.1 - 0.23 12.0 2.8 0.44 11.2 0.7 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DNA_primase_lrg PF04104.14 AMD19661.1 - 1.1e-82 277.4 0.1 1.5e-82 277.0 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Ribosomal_L29 PF00831.23 AMD19661.1 - 0.056 13.4 0.3 0.21 11.6 0.3 2.0 1 0 0 1 1 1 0 Ribosomal L29 protein KilA-N PF04383.13 AMD19662.1 - 0.0014 18.5 0.0 0.0014 18.5 0.0 3.8 3 2 0 3 3 3 1 KilA-N domain Caldesmon PF02029.15 AMD19662.1 - 3.3 6.4 56.8 1.9 7.2 0.3 3.1 3 0 0 3 3 3 0 Caldesmon Spc42p PF11544.8 AMD19663.1 - 1e-25 89.5 2.2 1e-25 89.5 2.2 3.9 4 0 0 4 4 4 2 Spindle pole body component Spc42p GHL13 PF14883.6 AMD19663.1 - 0.0034 16.5 0.8 0.0048 16.0 0.8 1.3 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase family 13 PhoU PF01895.19 AMD19663.1 - 0.0043 17.5 2.9 2.3 8.7 0.1 3.2 3 0 0 3 3 3 1 PhoU domain BBL5 PF07289.11 AMD19663.1 - 0.021 13.9 3.7 0.04 13.0 3.7 1.3 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein DUF812 PF05667.11 AMD19663.1 - 0.31 9.9 18.5 3.3 6.5 18.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF812) BUD22 PF09073.10 AMD19664.1 - 1.8e-71 241.8 34.7 2.4e-71 241.4 34.7 1.2 1 0 0 1 1 1 1 BUD22 FTR1 PF03239.14 AMD19665.1 - 9.9e-05 21.7 3.5 0.00024 20.4 3.5 1.6 1 0 0 1 1 1 1 Iron permease FTR1 family CLU PF13236.6 AMD19666.1 - 5.4e-57 193.2 0.1 1.3e-56 191.9 0.1 1.7 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 AMD19666.1 - 6.2e-36 124.1 0.0 4.9e-35 121.1 0.0 2.6 2 1 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 AMD19666.1 - 1.3e-15 57.5 1.0 1.3e-15 57.5 1.0 3.0 3 0 0 3 3 3 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 AMD19666.1 - 7e-10 38.5 1.1 2.2e-05 24.2 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD19666.1 - 4e-09 36.6 3.7 1.2e-05 25.5 0.3 3.8 4 1 1 5 5 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 AMD19666.1 - 0.0013 18.5 0.9 0.3 11.0 1.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 AMD19666.1 - 0.0056 16.7 5.3 0.027 14.6 0.7 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat AAA_9 PF12781.7 AMD19666.1 - 0.022 13.9 0.7 0.06 12.5 0.7 1.8 1 0 0 1 1 1 0 ATP-binding dynein motor region Rad60-SLD PF11976.8 AMD19666.1 - 0.028 14.3 0.3 0.11 12.4 0.3 2.1 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like TPR_7 PF13176.6 AMD19666.1 - 0.089 12.9 2.2 1.7 8.8 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 AMD19666.1 - 0.12 13.1 1.6 0.72 10.6 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 AMD19666.1 - 0.17 12.7 2.3 0.49 11.4 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Pur_ac_phosph_N PF16656.5 AMD19667.1 - 0.059 13.9 0.1 0.15 12.7 0.1 1.7 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain DnaJ_C PF01556.18 AMD19668.1 - 1.7e-29 102.9 0.0 2.4e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AMD19668.1 - 2e-21 75.9 0.6 4e-21 74.9 0.6 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AMD19668.1 - 2.4e-10 40.6 19.0 2.4e-10 40.6 19.0 1.8 2 0 0 2 2 1 1 DnaJ central domain RR_TM4-6 PF06459.12 AMD19668.1 - 0.042 13.7 11.3 0.072 12.9 11.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 AMD19668.1 - 0.13 12.1 15.5 0.24 11.2 15.5 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nop14 PF04147.12 AMD19668.1 - 0.29 9.3 26.3 0.41 8.8 26.3 1.1 1 0 0 1 1 1 0 Nop14-like family DARPP-32 PF05395.12 AMD19668.1 - 0.65 10.2 17.3 1.3 9.2 17.3 1.5 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 RNA_pol_Rpc4 PF05132.14 AMD19668.1 - 1.1 9.7 7.0 0.71 10.3 3.7 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 BUD22 PF09073.10 AMD19668.1 - 1.7 7.9 22.3 3.2 7.0 22.3 1.3 1 0 0 1 1 1 0 BUD22 RNA_pol_3_Rpc31 PF11705.8 AMD19668.1 - 2.7 8.2 29.3 5.8 7.1 29.3 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 VIR_N PF15912.5 AMD19668.1 - 3 7.4 14.1 4.8 6.7 14.1 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal DUF913 PF06025.12 AMD19668.1 - 3.3 6.6 6.2 4.8 6.0 6.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) LAP1C PF05609.12 AMD19668.1 - 3.7 6.5 11.1 6 5.8 11.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) NPR3 PF03666.13 AMD19668.1 - 4 6.1 11.0 6.7 5.4 11.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 AMD19668.1 - 7.3 4.7 23.7 12 4.1 23.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 AMD19668.1 - 8.4 5.5 10.3 15 4.7 10.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter MDM1 PF15501.6 AMD19668.1 - 9.7 5.2 18.5 17 4.4 18.5 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 CSN5_C PF18323.1 AMD19669.1 - 0.00034 21.5 9.4 0.092 13.7 1.1 3.0 3 1 0 3 3 2 2 Cop9 signalosome subunit 5 C-terminal domain DUF842 PF05811.13 AMD19669.1 - 0.00074 19.2 0.8 0.19 11.4 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic protein of unknown function (DUF842) DUF2508 PF10704.9 AMD19669.1 - 0.0019 18.3 0.2 0.0051 17.0 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2508) TPR_21 PF09976.9 AMD19669.1 - 0.0041 16.9 4.3 0.0071 16.1 4.3 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain DUF883 PF05957.13 AMD19669.1 - 0.0062 17.1 17.2 0.053 14.1 0.6 4.6 3 1 1 5 5 4 1 Bacterial protein of unknown function (DUF883) ApoO PF09769.9 AMD19669.1 - 0.0066 16.4 4.9 0.017 15.1 0.1 2.9 3 0 0 3 3 3 1 Apolipoprotein O ApoLp-III PF07464.11 AMD19669.1 - 0.013 15.6 8.5 0.03 14.4 1.7 2.8 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) TarH PF02203.15 AMD19669.1 - 0.014 15.4 0.5 2.2 8.2 0.3 2.5 2 0 0 2 2 2 0 Tar ligand binding domain homologue Chlorosome_CsmC PF11098.8 AMD19669.1 - 0.024 14.6 2.1 0.057 13.4 0.5 2.2 1 1 0 1 1 1 0 Chlorosome envelope protein C Prominin PF05478.11 AMD19669.1 - 0.03 12.3 2.6 0.9 7.4 0.1 2.0 2 0 0 2 2 2 0 Prominin MscS_porin PF12795.7 AMD19669.1 - 0.035 13.6 2.0 0.051 13.1 0.1 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Spc7 PF08317.11 AMD19669.1 - 0.056 12.3 4.3 0.11 11.3 0.6 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Apolipoprotein PF01442.18 AMD19669.1 - 0.091 12.6 15.8 0.029 14.3 9.4 2.6 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain mit_SMPDase PF14724.6 AMD19669.1 - 0.12 10.3 0.7 0.22 9.4 0.7 1.3 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase Y_phosphatase3 PF13350.6 AMD19669.1 - 0.28 11.1 3.0 0.55 10.2 0.5 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family YfdX PF10938.8 AMD19669.1 - 0.41 10.6 4.6 2.3 8.1 0.0 2.6 3 0 0 3 3 2 0 YfdX protein FAM184 PF15665.5 AMD19669.1 - 0.42 10.4 7.6 2.8 7.7 0.3 2.5 3 0 0 3 3 2 0 Family with sequence similarity 184, A and B Baculo_PEP_C PF04513.12 AMD19669.1 - 0.44 10.6 2.7 9.5 6.3 0.3 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus OmpH PF03938.14 AMD19669.1 - 0.55 10.6 9.7 2.4 8.5 0.1 2.6 3 0 0 3 3 2 0 Outer membrane protein (OmpH-like) Syntaxin_2 PF14523.6 AMD19669.1 - 0.96 9.9 9.3 0.19 12.1 0.5 3.1 2 1 1 3 3 3 0 Syntaxin-like protein YtxH PF12732.7 AMD19669.1 - 1.1 9.9 23.5 57 4.4 13.5 5.4 3 1 0 3 3 3 0 YtxH-like protein DUF2564 PF10819.8 AMD19669.1 - 1.2 9.5 10.9 0.2 12.0 2.0 3.7 3 2 0 4 4 4 0 Protein of unknown function (DUF2564) Exonuc_VII_L PF02601.15 AMD19669.1 - 2 7.9 7.7 11 5.4 7.7 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF1798 PF08807.10 AMD19669.1 - 3.6 7.8 5.2 20 5.3 0.2 3.0 2 1 0 3 3 3 0 Bacterial domain of unknown function (DUF1798) DUF1640 PF07798.11 AMD19669.1 - 6 6.9 6.6 15 5.6 0.2 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1640) DUF2959 PF11172.8 AMD19669.1 - 6.6 6.8 9.5 1 9.5 0.6 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF2959) RRF PF01765.19 AMD19669.1 - 7.3 6.5 8.7 4 7.4 0.3 2.8 3 0 0 3 3 2 0 Ribosome recycling factor Helicase_IV_N PF12462.8 AMD19669.1 - 9 6.2 6.9 7.1 6.5 0.3 2.9 3 0 0 3 3 3 0 DNA helicase IV / RNA helicase N terminal DUF1752 PF08550.10 AMD19670.1 - 1.8e-11 43.6 0.4 5.1e-11 42.2 0.1 2.0 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) Brix PF04427.18 AMD19671.1 - 5.9e-31 108.1 0.1 7.7e-31 107.7 0.1 1.1 1 0 0 1 1 1 1 Brix domain DUF4128 PF13554.6 AMD19671.1 - 0.032 14.3 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function Exog_C PF18026.1 AMD19671.1 - 0.061 13.4 0.1 0.52 10.4 0.0 2.6 3 0 0 3 3 3 0 Endo/exonuclease (EXOG) C-terminal domain PrmC_N PF17827.1 AMD19671.1 - 0.085 13.5 1.7 0.56 10.8 1.3 2.3 2 0 0 2 2 2 0 PrmC N-terminal domain tRNA-synt_2 PF00152.20 AMD19672.1 - 2e-61 207.8 0.0 2.7e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 AMD19672.1 - 1.3e-07 31.4 0.1 6.7e-05 22.5 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 AMD19672.1 - 2e-06 27.7 0.0 4.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 AMD19672.1 - 0.072 13.3 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RNase_HII PF01351.18 AMD19673.1 - 1.3e-63 214.4 0.0 1.6e-63 214.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII 2-oxoacid_dh PF00198.23 AMD19674.1 - 6e-71 238.6 0.2 7.8e-71 238.2 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AMD19674.1 - 8.3e-18 64.0 0.1 2.4e-17 62.5 0.1 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 AMD19674.1 - 1e-13 51.4 0.5 9e-13 48.3 0.2 2.5 2 0 0 2 2 2 1 e3 binding domain Ribosomal_60s PF00428.19 AMD19674.1 - 5.7 7.6 15.5 53 4.5 0.1 3.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Tom7 PF08038.12 AMD19675.1 - 4.6e-18 64.6 0.0 6.2e-18 64.2 0.0 1.2 1 0 0 1 1 1 1 TOM7 family Mito_carr PF00153.27 AMD19676.1 - 2.5e-53 178.0 9.3 9.9e-21 73.5 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF5516 PF17637.2 AMD19676.1 - 0.065 13.0 0.1 0.2 11.5 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5516) Ribosomal_L13 PF00572.18 AMD19677.1 - 2.4e-12 47.2 1.4 1e-10 41.9 0.1 2.5 2 1 0 2 2 2 1 Ribosomal protein L13 CSM2 PF16834.5 AMD19678.1 - 2e-38 132.1 0.0 5.2e-38 130.7 0.0 1.6 1 1 0 1 1 1 1 Shu complex component Csm2, DNA-binding Forkhead PF00250.18 AMD19679.1 - 1.2e-34 118.4 1.3 7.2e-34 115.9 0.1 2.7 3 0 0 3 3 3 1 Forkhead domain FHA PF00498.26 AMD19679.1 - 4.9e-11 42.8 0.0 1.7e-10 41.1 0.0 2.0 1 0 0 1 1 1 1 FHA domain Linker_histone PF00538.19 AMD19679.1 - 0.0029 17.9 0.0 0.0079 16.5 0.0 1.7 1 0 0 1 1 1 1 linker histone H1 and H5 family Fungal_trans PF04082.18 AMD19680.1 - 2e-28 99.2 0.1 3.5e-28 98.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD19680.1 - 2.6e-10 40.2 12.8 5e-10 39.3 12.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TTc_toxin_rep PF18807.1 AMD19681.1 - 0.061 13.1 0.2 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 Tripartite Tc toxins repeat SUN PF03856.13 AMD19682.1 - 8e-94 313.7 8.3 9.5e-94 313.4 8.3 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) SPX PF03105.19 AMD19682.1 - 0.86 9.5 6.2 1.1 9.1 6.2 1.2 1 0 0 1 1 1 0 SPX domain PRCC PF10253.9 AMD19682.1 - 1 10.1 7.8 1.5 9.5 7.8 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting adh_short PF00106.25 AMD19683.1 - 1.3e-45 155.3 0.1 1.7e-45 154.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AMD19683.1 - 4.1e-30 105.1 0.0 5.2e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD19683.1 - 4.7e-09 36.4 0.0 7.3e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AMD19683.1 - 9.9e-07 28.5 0.1 5e-06 26.1 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 AMD19683.1 - 0.0012 18.8 0.0 0.061 13.3 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase RmlD_sub_bind PF04321.17 AMD19683.1 - 0.0059 15.7 0.1 0.0093 15.1 0.1 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain F420_oxidored PF03807.17 AMD19683.1 - 0.0098 16.5 0.1 0.018 15.6 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.15 AMD19683.1 - 0.024 14.5 0.1 0.038 13.8 0.1 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Glyco_transf_4 PF13439.6 AMD19683.1 - 0.13 12.2 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 GDP_Man_Dehyd PF16363.5 AMD19683.1 - 0.14 11.5 0.0 1.2 8.5 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Transket_pyr PF02779.24 AMD19684.1 - 2.9e-61 206.3 0.0 4.6e-61 205.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 AMD19684.1 - 1.8e-53 181.5 0.0 2.5e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 AMD19684.1 - 2.5e-48 163.6 0.0 4.1e-48 162.9 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 AMD19684.1 - 4e-18 64.7 0.6 9.3e-18 63.5 0.6 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus Ribosomal_L6 PF00347.23 AMD19685.1 - 2.1e-29 102.0 10.0 1.1e-14 54.8 3.1 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 LRR_6 PF13516.6 AMD19685.1 - 0.13 12.4 1.7 0.68 10.1 0.1 2.9 3 0 0 3 3 3 0 Leucine Rich repeat SLS PF14611.6 AMD19685.1 - 0.13 12.0 0.1 0.22 11.3 0.1 1.6 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator SNF2_N PF00176.23 AMD19686.1 - 2.7e-75 253.3 0.6 9.4e-75 251.5 0.6 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD19686.1 - 5e-23 81.6 0.9 1.1e-18 67.6 0.0 4.0 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 AMD19686.1 - 8.6e-18 64.2 0.2 2.4e-17 62.8 0.2 1.8 1 0 0 1 1 1 1 Bromodomain ResIII PF04851.15 AMD19686.1 - 7.7e-10 39.0 0.0 7.7e-10 39.0 0.0 3.5 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit SnAC PF14619.6 AMD19686.1 - 2.2e-09 37.8 0.6 2.2e-09 37.8 0.6 4.1 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.13 AMD19686.1 - 3.2e-09 37.0 12.9 3.2e-09 37.0 12.9 3.5 3 0 0 3 3 3 1 HSA RRT14 PF17075.5 AMD19687.1 - 9.1e-50 169.5 21.8 1.1e-49 169.3 21.8 1.0 1 0 0 1 1 1 1 Regular of rDNA transcription protein 14 CsgA PF17334.2 AMD19687.1 - 0.045 14.5 1.1 0.045 14.5 1.1 1.8 1 1 0 1 1 1 0 Minor curli fiber component A DUF262 PF03235.14 AMD19687.1 - 7.3 6.7 13.1 10 6.2 12.8 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF262 MMS19_C PF12460.8 AMD19688.1 - 1.6e-82 277.9 18.9 1.6e-82 277.9 18.9 2.8 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 AMD19688.1 - 2.7e-81 273.0 3.9 1.2e-78 264.3 0.1 3.7 3 0 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 AMD19688.1 - 0.005 17.2 0.2 15 6.0 0.0 4.6 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.22 AMD19688.1 - 0.0069 16.5 0.8 1.5 9.3 0.1 4.9 6 0 0 6 6 6 1 HEAT repeat RTP1_C1 PF10363.9 AMD19688.1 - 0.0077 16.4 4.9 0.23 11.7 0.1 4.1 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 AMD19688.1 - 0.047 13.6 21.0 0.91 9.4 1.2 4.6 5 0 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_EZ PF13513.6 AMD19688.1 - 0.19 12.2 1.3 3.1 8.4 0.1 3.6 4 0 0 4 4 4 0 HEAT-like repeat Telomere_reg-2 PF10193.9 AMD19688.1 - 1.3 9.5 6.8 13 6.3 0.6 4.0 3 1 0 3 3 3 0 Telomere length regulation protein Vac14_Fab1_bd PF12755.7 AMD19688.1 - 3 8.5 7.4 11 6.7 0.1 4.7 4 1 0 5 5 5 0 Vacuolar 14 Fab1-binding region MOR2-PAG1_N PF14222.6 AMD19689.1 - 1.9e-171 571.8 8.3 4.6e-171 570.5 8.3 1.7 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 AMD19689.1 - 2e-86 290.0 2.8 7.2e-86 288.2 2.0 2.5 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 AMD19689.1 - 5.2e-27 94.0 17.7 2e-14 52.3 0.7 4.2 4 0 0 4 4 4 4 Cell morphogenesis central region ApoO PF09769.9 AMD19690.1 - 0.00025 21.0 1.8 0.06 13.3 0.1 3.2 2 1 0 3 3 3 3 Apolipoprotein O Aa_trans PF01490.18 AMD19691.1 - 8.7e-88 294.8 33.5 1e-87 294.5 33.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UPF0242 PF06785.11 AMD19691.1 - 3.3 7.8 6.6 4.4 7.4 0.7 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DNA_pol_B PF00136.21 AMD19692.1 - 7.4e-120 400.7 2.8 7.4e-120 400.7 2.8 1.5 2 0 0 2 2 2 1 DNA polymerase family B zf-DNA_Pol PF08996.10 AMD19692.1 - 6.7e-64 215.0 1.0 1.4e-63 214.0 1.0 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 AMD19692.1 - 5.4e-41 140.8 0.0 1e-40 139.9 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 AMD19692.1 - 2.8e-16 59.4 8.4 2.8e-16 59.4 8.4 2.1 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal zinc_ribbon_4 PF13717.6 AMD19692.1 - 0.19 11.7 2.4 11 6.1 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain SNARE PF05739.19 AMD19693.1 - 2.1e-10 40.4 1.7 2.1e-10 40.4 1.7 1.8 2 0 0 2 2 1 1 SNARE domain Synaptobrevin PF00957.21 AMD19693.1 - 1.7e-05 24.5 1.3 3.1e-05 23.7 1.3 1.5 1 0 0 1 1 1 1 Synaptobrevin Prominin PF05478.11 AMD19693.1 - 0.00089 17.4 1.9 0.001 17.1 1.9 1.1 1 0 0 1 1 1 1 Prominin Syntaxin_2 PF14523.6 AMD19693.1 - 0.001 19.4 19.4 0.22 11.9 5.1 3.9 2 2 0 2 2 2 2 Syntaxin-like protein DUF5345 PF17280.2 AMD19693.1 - 0.008 16.1 0.3 0.033 14.2 0.0 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5345) Occludin_ELL PF07303.13 AMD19693.1 - 0.01 16.6 4.2 0.027 15.2 0.5 2.6 2 1 0 2 2 2 0 Occludin homology domain Rx_N PF18052.1 AMD19693.1 - 0.012 15.8 0.3 0.051 13.8 0.1 2.2 1 1 1 2 2 2 0 Rx N-terminal domain Baculo_PEP_C PF04513.12 AMD19693.1 - 0.019 15.0 3.5 0.019 15.0 3.5 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus S6PP_C PF08472.10 AMD19693.1 - 0.035 14.0 0.2 0.09 12.6 0.1 1.7 2 0 0 2 2 2 0 Sucrose-6-phosphate phosphohydrolase C-terminal Tup_N PF08581.10 AMD19693.1 - 0.039 14.3 3.0 0.1 12.9 0.8 2.7 2 1 0 2 2 2 0 Tup N-terminal DUF4988 PF16378.5 AMD19693.1 - 0.051 13.2 0.5 0.12 12.0 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function Talin_middle PF09141.10 AMD19693.1 - 0.056 13.5 1.2 0.31 11.1 0.4 2.1 2 0 0 2 2 2 0 Talin, middle domain DUF1385 PF07136.11 AMD19693.1 - 0.077 12.3 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) Vac7 PF12751.7 AMD19693.1 - 0.095 12.1 1.8 0.62 9.4 0.1 2.0 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 Spc7 PF08317.11 AMD19693.1 - 0.15 10.9 10.4 0.02 13.8 5.4 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF3450 PF11932.8 AMD19693.1 - 0.16 11.3 9.0 0.32 10.3 9.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DHR10 PF18595.1 AMD19693.1 - 0.16 12.0 8.1 6.1 6.9 4.5 2.8 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain MCU PF04678.13 AMD19693.1 - 0.35 11.0 3.0 0.71 9.9 2.9 1.6 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF1664 PF07889.12 AMD19693.1 - 1.2 9.2 6.4 0.66 10.0 3.4 2.1 2 1 0 2 2 1 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 AMD19693.1 - 2.6 8.6 11.2 0.77 10.3 7.6 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 bZIP_2 PF07716.15 AMD19694.1 - 0.00022 21.2 3.3 0.00063 19.8 3.3 1.8 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 AMD19694.1 - 0.059 13.5 6.0 0.18 11.9 6.0 1.9 1 0 0 1 1 1 0 bZIP transcription factor RGS PF00615.19 AMD19695.1 - 2.6e-13 50.3 0.3 4.5e-13 49.5 0.3 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain HMGL-like PF00682.19 AMD19696.1 - 3.1e-85 285.9 0.0 4.2e-85 285.5 0.0 1.1 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 AMD19696.1 - 5.9e-25 87.7 1.0 1.8e-24 86.1 0.1 2.2 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain Syja_N PF02383.18 AMD19697.1 - 9.5e-77 258.4 0.1 1.8e-76 257.5 0.1 1.5 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 AMD19697.1 - 9e-14 51.6 0.0 1.5e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YEATS PF03366.16 AMD19699.1 - 4.6e-35 119.5 0.8 7.2e-35 118.8 0.8 1.3 1 0 0 1 1 1 1 YEATS family TFIIIC_sub6 PF10419.9 AMD19700.1 - 3.6e-22 78.0 0.1 6.2e-22 77.3 0.1 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain His_Phos_1 PF00300.22 AMD19700.1 - 2.9e-19 69.5 0.0 4.8e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Maf PF02545.14 AMD19701.1 - 9.3e-38 129.7 0.0 1.1e-37 129.4 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein RRM_1 PF00076.22 AMD19702.1 - 2.2e-17 62.6 0.2 6.4e-17 61.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 AMD19702.1 - 0.048 13.6 0.7 0.15 12.0 0.1 2.1 2 1 0 2 2 2 0 RL domain Cyt-b5 PF00173.28 AMD19703.1 - 2.1e-25 88.6 0.1 2.7e-25 88.3 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cnd1 PF12717.7 AMD19704.1 - 0.013 15.6 1.1 3.4 7.7 0.1 2.9 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 CK1gamma_C PF12605.8 AMD19704.1 - 0.44 11.7 4.0 0.29 12.4 0.9 2.1 1 1 1 2 2 2 0 Casein kinase 1 gamma C terminal DEAD PF00270.29 AMD19705.1 - 4.4e-49 166.6 0.0 1.4e-48 165.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19705.1 - 5.7e-33 113.6 0.0 1.4e-31 109.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD19705.1 - 0.00033 20.7 0.0 0.00068 19.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF5335 PF17269.2 AMD19705.1 - 0.013 15.4 0.1 0.028 14.3 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5335) UTP25 PF06862.12 AMD19705.1 - 0.031 13.1 0.0 0.39 9.4 0.0 2.3 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 AMD19705.1 - 0.053 13.9 0.0 7.7 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain ERCC3_RAD25_C PF16203.5 AMD19705.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase RNA_pol_L_2 PF13656.6 AMD19706.1 - 1.9e-34 117.3 0.1 2.5e-34 116.9 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 AMD19706.1 - 1.5e-14 53.1 0.0 2.2e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-C2H2 PF00096.26 AMD19707.1 - 7.2e-23 79.7 30.2 1.3e-06 28.5 0.4 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD19707.1 - 1.3e-22 79.2 28.3 4.7e-09 36.3 0.8 4.5 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD19707.1 - 4e-14 52.1 26.2 0.00038 21.0 0.2 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AMD19707.1 - 0.0014 18.5 28.0 0.016 15.2 0.6 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 AMD19707.1 - 0.04 14.2 10.6 0.15 12.4 0.6 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 AMD19707.1 - 0.048 14.1 15.4 9 6.8 0.1 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DZR PF12773.7 AMD19707.1 - 0.53 10.3 6.6 3.5 7.7 6.7 2.1 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_2 PF12756.7 AMD19707.1 - 2.2 8.7 16.7 18 5.8 2.9 3.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) TRAPP PF04051.16 AMD19708.1 - 3.9e-34 117.5 0.0 5.6e-34 117.0 0.0 1.3 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component SH3_9 PF14604.6 AMD19709.1 - 1.3e-22 79.4 0.2 3.2e-12 46.1 0.0 2.9 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 AMD19709.1 - 4.5e-22 77.4 0.1 2.1e-12 46.4 0.1 2.9 3 0 0 3 3 3 2 SH3 domain FCH PF00611.23 AMD19709.1 - 1.4e-18 66.9 0.1 6.8e-18 64.7 0.0 2.3 1 1 1 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 AMD19709.1 - 3.1e-12 46.0 0.4 1.6e-09 37.3 0.1 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 AMD19709.1 - 0.0014 18.8 1.5 0.012 15.9 0.1 2.8 3 0 0 3 3 3 1 Bacterial SH3 domain SH3_10 PF17902.1 AMD19709.1 - 0.062 13.4 0.0 0.66 10.1 0.0 2.4 2 0 0 2 2 2 0 SH3 domain AATF-Che1 PF13339.6 AMD19709.1 - 1.2 9.8 14.8 19 5.9 0.3 3.0 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Baculo_PEP_C PF04513.12 AMD19709.1 - 5 7.2 6.2 2.9 7.9 0.5 2.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus KxDL PF10241.9 AMD19709.1 - 5.7 7.3 9.9 1.6 9.0 0.2 3.9 3 2 0 3 3 3 0 Uncharacterized conserved protein DUF2417 PF10329.9 AMD19710.1 - 3e-54 184.0 7.1 4.3e-54 183.4 7.1 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.20 AMD19710.1 - 1.1e-11 44.9 0.0 6.8e-11 42.3 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AMD19710.1 - 8.9e-07 29.7 0.0 1.6e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family LptF_LptG PF03739.14 AMD19710.1 - 0.22 10.3 6.9 0.24 10.2 0.0 2.7 2 1 0 3 3 3 0 Lipopolysaccharide export system permease LptF/LptG CrgA PF06781.12 AMD19710.1 - 0.65 10.1 3.8 0.5 10.5 1.1 2.3 1 1 1 2 2 2 0 Cell division protein CrgA FHA PF00498.26 AMD19711.1 - 2.1e-15 56.8 0.0 4.4e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 AMD19711.1 - 6.1e-11 41.9 10.9 1.1e-10 41.0 10.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 AMD19711.1 - 5.8e-07 29.7 14.0 9.7e-07 29.0 14.0 1.4 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 AMD19711.1 - 5.5e-05 23.4 0.0 0.00016 21.9 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.6 AMD19711.1 - 0.0037 17.2 12.0 0.0061 16.5 12.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 AMD19711.1 - 0.0043 17.3 9.9 0.0097 16.2 9.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AMD19711.1 - 0.0047 16.8 14.0 0.0082 16.0 14.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AMD19711.1 - 0.0078 16.2 6.5 0.016 15.3 6.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 AMD19711.1 - 0.061 13.2 13.6 0.11 12.4 13.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Sec_GG PF07549.14 AMD19711.1 - 0.089 12.3 0.2 0.15 11.5 0.2 1.4 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-RING_UBOX PF13445.6 AMD19711.1 - 0.36 10.9 12.2 0.72 9.9 12.2 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Malate_synthase PF01274.22 AMD19712.1 - 1.6e-205 683.4 0.0 1.9e-205 683.1 0.0 1.0 1 0 0 1 1 1 1 Malate synthase NMT1 PF09084.11 AMD19713.1 - 5.9e-16 59.1 0.0 8.8e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 AMD19713.1 - 4.9e-08 33.0 0.0 6.9e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 AMD19713.1 - 1e-06 28.3 0.0 2.2e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysR_substrate PF03466.20 AMD19713.1 - 0.00016 21.1 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain DCP2 PF05026.13 AMD19714.1 - 1.2e-25 89.6 0.5 3.7e-25 88.1 0.5 1.9 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 AMD19714.1 - 4.3e-11 43.0 0.0 1e-10 41.7 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain L27 PF02828.16 AMD19714.1 - 0.064 13.0 2.3 7.5 6.4 0.1 3.3 3 0 0 3 3 3 0 L27 domain DHHA2 PF02833.14 AMD19714.1 - 0.068 13.4 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 DHHA2 domain CTU2 PF10288.9 AMD19715.1 - 2.6e-23 82.4 2.3 2.6e-23 82.4 2.3 2.1 2 0 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 MTCP1 PF08991.10 AMD19716.1 - 1e-05 25.6 3.6 1.6e-05 25.0 3.6 1.3 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 AMD19716.1 - 5.4e-05 23.2 7.1 7.9e-05 22.7 7.1 1.3 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 AMD19716.1 - 0.049 13.9 3.4 0.074 13.4 3.4 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 TPR_2 PF07719.17 AMD19717.1 - 2.8e-26 89.5 40.7 3.5e-05 23.6 0.0 11.8 10 2 2 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 AMD19717.1 - 1.1e-23 82.0 37.6 4.1e-06 26.4 0.1 10.8 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 AMD19717.1 - 1.3e-21 76.9 7.9 0.0019 18.8 0.9 6.7 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 AMD19717.1 - 1.5e-18 67.1 21.1 4.8e-05 23.8 2.4 7.6 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 AMD19717.1 - 1.1e-16 60.0 15.4 0.0081 16.9 0.3 9.4 5 2 5 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 AMD19717.1 - 1.9e-14 52.6 29.6 0.023 14.9 0.0 10.7 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_11 PF13414.6 AMD19717.1 - 9.5e-14 50.8 18.3 0.0019 17.9 0.0 8.3 6 2 2 8 8 8 3 TPR repeat TPR_17 PF13431.6 AMD19717.1 - 3.3e-12 45.9 12.6 0.0002 21.5 0.0 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD19717.1 - 2.8e-11 43.5 18.9 0.0078 16.5 0.6 8.1 6 3 2 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD19717.1 - 3.9e-08 33.4 17.6 0.003 17.7 0.4 5.4 4 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 AMD19717.1 - 2.8e-06 27.4 1.2 0.42 10.8 0.0 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 AMD19717.1 - 6.4e-06 25.8 1.2 1.5 8.4 0.2 4.3 3 1 2 5 5 5 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_MalT PF17874.1 AMD19717.1 - 4.6e-05 23.0 2.9 0.012 15.1 1.2 3.6 1 1 2 3 3 3 1 MalT-like TPR region TPR_15 PF13429.6 AMD19717.1 - 0.00051 19.3 10.6 0.57 9.3 0.0 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 AMD19717.1 - 0.00071 19.9 10.7 0.28 11.5 1.7 5.0 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 AMD19717.1 - 0.0011 19.5 19.7 20 6.1 0.4 8.9 9 0 0 9 9 8 0 Tetratricopeptide repeat PknG_TPR PF16918.5 AMD19717.1 - 0.0036 16.1 0.9 0.5 9.0 0.0 2.5 1 1 1 2 2 2 1 Protein kinase G tetratricopeptide repeat TPR_7 PF13176.6 AMD19717.1 - 0.0064 16.4 16.4 1.5 9.0 0.2 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat SPO22 PF08631.10 AMD19717.1 - 0.45 9.9 4.7 0.54 9.7 0.3 2.8 4 0 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like TPR_21 PF09976.9 AMD19717.1 - 0.87 9.3 18.1 0.79 9.4 0.1 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat-like domain PTS_IIA PF02255.16 AMD19717.1 - 0.89 9.6 11.9 1.6 8.9 0.6 5.0 4 2 1 5 5 5 0 PTS system, Lactose/Cellobiose specific IIA subunit TOM20_plant PF06552.12 AMD19717.1 - 1.1 9.0 19.1 8.4 6.1 0.3 5.6 3 1 3 6 6 6 0 Plant specific mitochondrial import receptor subunit TOM20 PPR_2 PF13041.6 AMD19717.1 - 4.4 7.6 5.6 32 4.8 0.1 4.1 4 0 0 4 4 3 0 PPR repeat family ANAPC5 PF12862.7 AMD19717.1 - 5.6 7.1 7.5 8.2 6.6 0.4 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 Exonuc_VII_S PF02609.16 AMD19717.1 - 5.9 7.0 14.1 0.22 11.6 0.7 4.6 5 0 0 5 5 4 0 Exonuclease VII small subunit TPR_3 PF07720.12 AMD19717.1 - 7.8 6.6 12.7 0.15 12.0 2.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat Ribosomal_L35p PF01632.19 AMD19719.1 - 3.2e-12 46.8 6.0 3.9e-12 46.5 6.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 PDZ_1 PF12812.7 AMD19720.1 - 4e-54 180.6 0.1 1.2e-36 124.6 0.0 3.4 4 0 0 4 4 4 2 PDZ-like domain Trypsin_2 PF13365.6 AMD19720.1 - 2.1e-23 83.9 0.0 4.3e-21 76.4 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ PF00595.24 AMD19720.1 - 4.5e-12 46.1 0.4 2.1e-06 28.0 0.1 3.8 4 0 0 4 4 4 2 PDZ domain PDZ_6 PF17820.1 AMD19720.1 - 5.4e-12 45.4 0.4 1.2e-05 25.0 0.1 4.3 4 0 0 4 4 4 2 PDZ domain PDZ_2 PF13180.6 AMD19720.1 - 2.3e-11 43.9 1.1 2.1e-05 24.7 0.0 4.2 4 0 0 4 4 4 2 PDZ domain Tricorn_PDZ PF14685.6 AMD19720.1 - 0.00011 22.1 0.5 1.1 9.2 0.1 4.1 4 0 0 4 4 4 1 Tricorn protease PDZ domain Trypsin PF00089.26 AMD19720.1 - 0.004 17.0 0.0 0.011 15.6 0.0 1.7 1 1 0 1 1 1 1 Trypsin DUF31 PF01732.16 AMD19720.1 - 0.024 14.2 0.3 0.037 13.6 0.3 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S46 PF10459.9 AMD19720.1 - 0.036 12.7 0.7 0.52 8.9 0.0 2.1 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S7 PF00949.21 AMD19720.1 - 0.17 11.7 0.2 0.38 10.6 0.2 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease ORC6 PF05460.13 AMD19721.1 - 8.4e-95 318.1 0.2 1e-94 317.8 0.2 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) BES1_N PF05687.13 AMD19721.1 - 0.14 12.6 0.3 0.14 12.6 0.3 2.5 3 0 0 3 3 3 0 BES1/BZR1 plant transcription factor, N-terminal N-SET PF11764.8 AMD19722.1 - 3.4e-50 170.5 0.6 3.4e-50 170.5 0.6 3.0 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.28 AMD19722.1 - 1.4e-17 64.6 5.9 5.1e-17 62.8 0.1 3.4 2 2 0 3 3 3 1 SET domain SET_assoc PF11767.8 AMD19722.1 - 7.2e-17 60.8 0.1 2.6e-16 59.0 0.1 2.0 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated DUF2977 PF11192.8 AMD19722.1 - 0.053 13.6 0.2 0.19 11.9 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2977) MutS_V PF00488.21 AMD19723.1 - 7.1e-67 225.1 0.0 1.3e-66 224.3 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AMD19723.1 - 1.7e-33 116.5 3.7 4.3e-33 115.2 3.7 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 AMD19723.1 - 2.7e-27 95.2 0.0 6e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 AMD19723.1 - 4.4e-12 46.5 0.0 1.2e-11 45.0 0.0 1.8 1 0 0 1 1 1 1 MutS domain II AAA_23 PF13476.6 AMD19723.1 - 6.3 7.2 10.7 0.97 9.9 0.1 3.5 3 1 0 3 3 3 0 AAA domain Gar1 PF04410.14 AMD19724.1 - 3.1e-42 143.9 0.3 6.4e-42 142.9 0.3 1.5 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region GCP_C_terminal PF04130.13 AMD19725.1 - 1.1e-36 126.9 7.3 2e-36 126.1 4.6 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 AMD19725.1 - 1.3e-30 107.1 4.7 1.5e-30 106.9 1.7 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal CotJB PF12652.7 AMD19725.1 - 1.4 9.2 4.4 8.8 6.6 0.1 3.3 4 0 0 4 4 4 0 CotJB protein N1221 PF07923.13 AMD19726.1 - 2.5e-64 217.2 3.9 2.5e-64 217.2 3.9 1.9 2 0 0 2 2 2 1 N1221-like protein DUF3402 PF11882.8 AMD19726.1 - 8.6e-53 180.1 14.9 1.8e-29 103.2 6.6 3.7 2 1 1 3 3 3 2 Domain of unknown function (DUF3402) Vac_Fusion PF02346.16 AMD19726.1 - 0.092 12.4 0.3 1 9.0 0.1 2.8 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 AD PF09793.9 AMD19727.1 - 3.1e-24 84.9 0.3 6.3e-24 83.9 0.1 1.6 2 0 0 2 2 2 1 Anticodon-binding domain NAGLU PF05089.12 AMD19727.1 - 0.097 11.6 0.0 0.26 10.2 0.0 1.6 2 0 0 2 2 2 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain DSPc PF00782.20 AMD19728.1 - 3e-10 40.0 0.0 5.9e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AMD19728.1 - 0.037 14.0 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 AMD19728.1 - 0.042 13.4 0.0 0.095 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 AMD19728.1 - 0.062 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate AAA_18 PF13238.6 AMD19729.1 - 0.00034 21.1 0.0 0.0017 18.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 AMD19729.1 - 0.00083 19.1 0.1 0.0027 17.5 0.1 1.7 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 AMD19729.1 - 0.0081 16.5 0.0 0.011 16.2 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 AMD19729.1 - 0.012 15.7 0.0 0.045 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AMD19729.1 - 0.037 14.3 0.0 0.084 13.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain DUF927 PF06048.11 AMD19729.1 - 0.091 12.3 0.0 0.34 10.4 0.0 1.8 3 0 0 3 3 3 0 Domain of unknown function (DUF927) Cytidylate_kin PF02224.18 AMD19729.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase FeS_assembly_P PF01883.19 AMD19730.1 - 2.3e-08 34.1 0.0 5.2e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein CDP-OH_P_transf PF01066.21 AMD19731.1 - 7.7e-16 58.6 0.1 7.7e-16 58.6 0.1 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Tom22 PF04281.13 AMD19732.1 - 4.7e-46 156.0 0.0 5.3e-46 155.9 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 GNAT_acetyltr_2 PF13718.6 AMD19733.1 - 3.5e-98 327.5 2.2 6.2e-98 326.7 0.0 2.3 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 AMD19733.1 - 4.4e-86 288.4 4.6 4.4e-86 288.4 4.6 1.9 3 0 0 3 3 3 1 Possible tRNA binding domain Helicase_RecD PF05127.14 AMD19733.1 - 2.8e-65 219.5 0.0 1.4e-64 217.2 0.0 2.2 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 AMD19733.1 - 1.1e-34 118.3 0.0 3.3e-34 116.7 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 AMD19733.1 - 0.0062 16.3 0.0 0.26 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 AMD19733.1 - 0.035 14.4 0.0 0.24 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AMD19733.1 - 0.039 14.2 0.0 1.5 9.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain NDT80_PhoG PF05224.12 AMD19734.1 - 5.4e-68 228.9 0.6 1.4e-67 227.5 0.6 1.7 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family HIM1 PF08732.10 AMD19735.1 - 5.4e-56 188.7 0.0 8.6e-56 188.1 0.0 1.3 1 0 0 1 1 1 1 HIM1 CENP-O PF09496.10 AMD19736.1 - 3.9e-12 46.6 0.1 1.2e-11 45.1 0.1 1.8 1 1 0 1 1 1 1 Cenp-O kinetochore centromere component Cnn_1N PF07989.11 AMD19736.1 - 0.29 11.3 5.2 5.2 7.3 1.0 3.2 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 Scs3p PF10261.9 AMD19737.1 - 4.7e-19 68.9 21.6 4.5e-13 49.3 8.2 2.5 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 AMD19737.1 - 2.1e-05 24.3 1.4 5e-05 23.1 1.4 1.6 1 0 0 1 1 1 1 PAP2 superfamily SQHop_cyclase_C PF13243.6 AMD19738.1 - 6.3e-45 153.7 0.0 2.1e-44 151.9 0.0 1.7 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 AMD19738.1 - 6.9e-33 114.0 0.0 1.3e-27 96.7 0.0 3.2 2 1 1 3 3 3 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 AMD19738.1 - 5e-27 93.3 0.4 7.8e-08 31.9 0.2 4.4 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 AMD19738.1 - 0.00039 19.8 0.1 0.015 14.6 0.0 2.7 2 1 1 3 3 3 1 Pectic acid lyase TED_complement PF07678.14 AMD19738.1 - 0.0053 15.8 0.1 0.017 14.2 0.1 1.7 2 0 0 2 2 2 1 A-macroglobulin TED domain Ubiq-assoc PF09145.10 AMD19739.1 - 1.5e-13 50.5 0.9 3.1e-13 49.5 0.9 1.5 1 0 0 1 1 1 1 Ubiquitin-associated DnaJ PF00226.31 AMD19739.1 - 0.0036 17.4 0.0 0.01 15.9 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 AMD19739.1 - 0.043 13.9 0.2 27 5.2 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF357 PF04010.13 AMD19739.1 - 0.17 12.0 0.1 16 5.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF357) DUF4834 PF16118.5 AMD19740.1 - 0.0022 18.9 0.4 0.0035 18.3 0.4 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) Ctr PF04145.15 AMD19740.1 - 0.08 13.6 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Ctr copper transporter family Nop10p PF04135.12 AMD19741.1 - 3.5e-23 81.4 0.6 3.9e-23 81.2 0.6 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family DASH_Dad4 PF08650.10 AMD19742.1 - 9.3e-34 115.2 5.3 1e-33 115.1 5.3 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 NPV_P10 PF05531.12 AMD19742.1 - 0.0031 17.9 0.5 0.0035 17.8 0.5 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein DUF3251 PF11622.8 AMD19742.1 - 0.018 14.7 0.1 0.022 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) DUF1758 PF05585.12 AMD19742.1 - 0.068 12.9 0.1 0.072 12.9 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase (DUF1758) DivIC PF04977.15 AMD19742.1 - 0.068 12.9 1.2 0.089 12.6 1.2 1.3 1 0 0 1 1 1 0 Septum formation initiator PhaP_Bmeg PF09602.10 AMD19742.1 - 0.078 12.9 0.2 0.084 12.8 0.2 1.0 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) FAM117 PF15388.6 AMD19742.1 - 0.17 11.3 0.6 0.18 11.2 0.6 1.1 1 0 0 1 1 1 0 Protein Family FAM117 Oxysterol_BP PF01237.18 AMD19743.1 - 1.5e-101 340.0 0.1 1.5e-101 340.0 0.1 2.7 3 1 0 3 3 3 1 Oxysterol-binding protein PH_8 PF15409.6 AMD19743.1 - 3.2e-32 110.6 0.9 8.1e-32 109.4 0.9 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AMD19743.1 - 8.7e-05 23.0 0.8 0.0003 21.3 0.8 2.0 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 AMD19743.1 - 0.0007 19.7 0.7 0.0014 18.7 0.7 1.5 1 0 0 1 1 1 1 PH domain Moulting_cycle PF04870.16 AMD19743.1 - 0.12 11.6 1.8 0.72 9.1 0.0 2.2 2 0 0 2 2 2 0 Moulting cycle PH_11 PF15413.6 AMD19743.1 - 0.13 12.7 10.1 0.53 10.7 7.1 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain Asparaginase PF00710.20 AMD19744.1 - 2.3e-55 187.1 0.0 3.9e-55 186.4 0.0 1.4 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 AMD19744.1 - 4.5e-17 62.3 0.0 8.9e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ribosomal_L19 PF01245.20 AMD19744.1 - 0.046 13.6 0.0 2.9 7.8 0.0 2.7 3 0 0 3 3 3 0 Ribosomal protein L19 Tipalpha PF16753.5 AMD19744.1 - 0.19 11.5 0.2 1.9 8.3 0.0 2.4 3 0 0 3 3 3 0 TNF-alpha-Inducing protein of Helicobacter CN_hydrolase PF00795.22 AMD19745.1 - 9.8e-44 149.6 0.0 1.3e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 AMD19745.1 - 2.1e-24 86.0 0.0 6.6e-24 84.4 0.0 1.7 1 1 0 1 1 1 1 NAD synthase Abhydrolase_6 PF12697.7 AMD19746.1 - 9e-23 82.0 0.0 1.2e-22 81.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AMD19746.1 - 9.8e-12 45.0 0.1 5.3e-11 42.6 0.0 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AMD19746.1 - 1.2e-08 34.5 0.1 2.2e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 AMD19746.1 - 0.0012 19.1 0.1 0.01 16.0 0.1 2.2 1 1 0 1 1 1 1 Thioesterase domain LIDHydrolase PF10230.9 AMD19746.1 - 0.0039 16.8 0.0 0.0056 16.3 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 AMD19746.1 - 0.0042 17.0 0.0 0.0076 16.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase2 PF12740.7 AMD19746.1 - 0.0063 15.4 0.2 0.012 14.5 0.2 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme DUF676 PF05057.14 AMD19746.1 - 0.011 15.2 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Spike_torovirin PF17072.5 AMD19746.1 - 0.016 12.4 0.0 0.023 11.9 0.0 1.1 1 0 0 1 1 1 0 Torovirinae spike glycoprotein DUF2974 PF11187.8 AMD19746.1 - 0.018 14.6 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 AMD19746.1 - 0.019 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Cutinase PF01083.22 AMD19746.1 - 0.041 13.8 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 Cutinase Abhydrolase_3 PF07859.13 AMD19746.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 AMD19746.1 - 0.08 12.8 0.0 0.71 9.7 0.1 2.0 2 0 0 2 2 2 0 Serine hydrolase BAAT_C PF08840.11 AMD19746.1 - 0.12 12.3 0.0 7.4 6.4 0.0 2.2 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_M1 PF01433.20 AMD19747.1 - 4.6e-69 232.3 0.2 8.3e-69 231.5 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 AMD19747.1 - 5.6e-52 177.2 0.0 1.1e-51 176.3 0.0 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 AMD19747.1 - 2e-50 171.6 1.8 1.2e-49 169.0 0.9 2.1 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain PBP PF01161.20 AMD19748.1 - 1.1e-06 29.0 0.0 2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ATP-synt_E PF05680.12 AMD19749.1 - 8.5e-22 77.3 0.1 9.3e-22 77.2 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain SpoIIE PF07228.12 AMD19750.1 - 9.5e-32 110.5 0.0 1.3e-31 110.1 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 AMD19750.1 - 6.4e-05 22.7 0.1 0.15 11.7 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 AMD19750.1 - 0.00015 21.5 0.0 0.00026 20.7 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3898 PF13037.6 AMD19750.1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3898) MIF4G PF02854.19 AMD19751.1 - 5e-35 121.1 28.5 3.7e-21 75.8 0.1 4.0 4 1 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 AMD19751.1 - 1.5e-23 84.0 2.3 1.5e-23 84.0 2.3 2.5 2 0 0 2 2 2 1 Up-frameshift suppressor 2 PAF PF15715.5 AMD19751.1 - 8.2 7.0 10.7 1.2 9.7 5.6 2.2 2 0 0 2 2 2 0 PCNA-associated factor histone like domain FYVE PF01363.21 AMD19752.1 - 1.2e-18 67.0 24.6 3.8e-16 59.0 5.6 2.8 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 AMD19752.1 - 6.7e-14 51.3 1.1 1.3e-13 50.4 1.1 1.5 1 0 0 1 1 1 1 Rabenosyn Rab binding domain ABC_tran_CTD PF16326.5 AMD19752.1 - 0.0062 16.8 4.7 0.037 14.3 0.3 3.3 3 0 0 3 3 3 1 ABC transporter C-terminal domain EutA PF06277.11 AMD19752.1 - 0.031 13.1 4.0 0.56 9.0 0.9 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation protein EutA zf-ribbon_3 PF13248.6 AMD19752.1 - 0.04 13.3 5.0 0.98 8.9 2.0 3.4 2 1 0 2 2 2 0 zinc-ribbon domain zf-Di19 PF05605.12 AMD19752.1 - 0.088 13.1 3.5 0.56 10.6 0.0 2.9 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Csm1_N PF18504.1 AMD19752.1 - 0.11 12.9 0.5 0.11 12.9 0.5 2.3 2 1 0 2 2 2 0 Csm1 N-terminal domain Siva PF05458.12 AMD19752.1 - 0.16 11.7 11.0 1 9.0 0.9 2.9 3 0 0 3 3 3 0 Cd27 binding protein (Siva) zf-met PF12874.7 AMD19752.1 - 1.2 9.6 0.0 1.2 9.6 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 AMD19752.1 - 2.9 8.5 0.0 2.9 8.5 0.0 5.2 5 1 1 6 6 5 0 Zinc finger, C2H2 type TMF_DNA_bd PF12329.8 AMD19752.1 - 3.6 7.6 5.8 0.43 10.6 0.2 2.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding ABA_GPCR PF12430.8 AMD19753.1 - 1.7e-57 194.1 5.9 1.7e-57 194.1 5.9 2.4 2 1 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 AMD19753.1 - 9.9e-11 41.6 4.9 4.9e-10 39.3 4.9 2.3 1 1 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal DUF2427 PF10348.9 AMD19753.1 - 0.17 11.7 4.9 0.52 10.1 4.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF2427) WD40 PF00400.32 AMD19754.1 - 4.3e-12 46.3 11.3 0.34 11.9 0.0 9.0 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19754.1 - 1.2e-05 25.5 10.5 0.69 10.2 0.2 6.9 3 3 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Cnd3 PF12719.7 AMD19755.1 - 6.5e-96 321.0 8.4 2.9e-94 315.5 4.5 3.3 3 1 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 AMD19755.1 - 1.7e-09 37.1 0.5 1.2 9.6 0.0 5.9 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 AMD19755.1 - 7.3e-09 35.9 0.0 6.3e-05 23.3 0.0 4.1 3 1 2 5 5 5 2 HEAT repeats Cnd1 PF12717.7 AMD19755.1 - 3.5e-07 30.4 4.2 0.00048 20.2 0.1 4.3 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 AMD19755.1 - 8.1e-06 26.2 0.3 0.42 11.2 0.0 5.0 4 1 1 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 AMD19755.1 - 0.021 15.4 0.1 0.31 11.7 0.1 3.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Pkinase PF00069.25 AMD19756.1 - 1.7e-42 145.6 0.0 9.3e-40 136.6 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.12 AMD19756.1 - 6.5e-42 142.7 0.0 2.2e-41 141.0 0.0 2.0 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 AMD19756.1 - 6.8e-25 87.8 0.0 6.7e-22 78.0 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD19756.1 - 1e-05 24.5 0.4 1.8e-05 23.8 0.4 1.3 1 0 0 1 1 1 1 Fungal protein kinase PQQ_2 PF13360.6 AMD19756.1 - 0.00066 19.3 0.0 13 5.2 0.0 2.2 1 1 0 1 1 1 1 PQQ-like domain Kdo PF06293.14 AMD19756.1 - 0.0012 18.2 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ PF01011.21 AMD19756.1 - 0.066 13.2 2.8 8.6 6.5 0.0 3.7 4 0 0 4 4 4 0 PQQ enzyme repeat Swi5 PF07061.11 AMD19757.1 - 4.4e-21 74.8 0.9 5.2e-21 74.5 0.9 1.1 1 0 0 1 1 1 1 Swi5 Y1_Tnp PF01797.16 AMD19757.1 - 0.067 13.3 0.3 0.11 12.6 0.3 1.4 1 1 0 1 1 1 0 Transposase IS200 like VASt PF16016.5 AMD19758.1 - 3e-72 242.1 0.2 3.5e-35 121.7 0.0 2.6 2 0 0 2 2 2 2 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 AMD19758.1 - 8.9e-22 77.1 0.1 2e-21 76.0 0.1 1.7 1 0 0 1 1 1 1 GRAM domain Skp1 PF01466.19 AMD19759.1 - 4.2e-24 84.4 0.3 4.2e-24 84.4 0.3 2.4 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 AMD19759.1 - 2e-14 53.5 0.2 1.9e-06 27.9 0.1 2.4 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain Peroxin-3 PF04882.12 AMD19760.1 - 3.8e-87 293.3 11.7 3.5e-69 234.0 2.6 2.0 1 1 1 2 2 2 2 Peroxin-3 Ctr PF04145.15 AMD19760.1 - 6.3 7.4 7.3 2.3 8.8 2.9 2.4 2 2 0 2 2 2 0 Ctr copper transporter family Sas10_Utp3 PF04000.15 AMD19761.1 - 1.5e-06 28.7 4.7 1.5e-06 28.7 4.7 2.2 2 1 0 2 2 2 1 Sas10/Utp3/C1D family TLE_N PF03920.15 AMD19761.1 - 1.5 8.9 10.3 1.8 8.7 0.3 3.1 1 1 1 3 3 3 0 Groucho/TLE N-terminal Q-rich domain Rpp20 PF12328.8 AMD19761.1 - 3.5 7.6 9.1 0.26 11.2 2.4 2.3 2 1 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Thioredoxin_7 PF13899.6 AMD19762.1 - 2.3e-23 82.2 0.1 4.1e-23 81.4 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 AMD19762.1 - 3.7e-17 62.3 0.1 8.9e-17 61.1 0.1 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 AMD19762.1 - 3.9e-13 49.0 0.0 6.9e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Thioredox_DsbH PF03190.15 AMD19762.1 - 0.0077 16.2 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_2 PF13098.6 AMD19762.1 - 0.0099 16.3 0.0 0.031 14.7 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like domain Peptidase_C13 PF01650.18 AMD19763.1 - 1.4e-45 155.8 1.3 2.1e-45 155.3 1.3 1.2 1 0 0 1 1 1 1 Peptidase C13 family Pkinase PF00069.25 AMD19764.1 - 3e-47 161.2 1.4 1.3e-42 146.0 0.4 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19764.1 - 8.1e-25 87.6 0.2 9.5e-24 84.1 0.1 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD19764.1 - 5.8e-08 32.4 0.0 9.9e-08 31.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AMD19764.1 - 0.038 12.8 0.0 0.087 11.6 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase CDV3 PF15359.6 AMD19764.1 - 0.047 14.2 7.5 1.5 9.3 0.1 3.8 2 1 2 4 4 4 0 Carnitine deficiency-associated protein 3 Kdo PF06293.14 AMD19764.1 - 0.048 13.0 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 AMD19764.1 - 0.059 13.0 0.5 1.1 8.8 0.5 2.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ResIII PF04851.15 AMD19765.1 - 7.3e-24 84.7 0.1 1.7e-23 83.5 0.1 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AMD19765.1 - 8.4e-15 55.1 0.9 3.9e-13 49.7 0.1 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD19765.1 - 1e-14 54.7 0.2 1e-14 54.7 0.2 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 AMD19765.1 - 2.3e-07 30.7 0.4 4.9e-07 29.7 0.4 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 AMD19765.1 - 5.8e-06 26.6 0.5 7.1e-05 23.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 AMD19765.1 - 7.4e-05 22.1 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF1877 PF08974.10 AMD19765.1 - 0.062 13.4 1.9 0.13 12.3 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) Flavi_DEAD PF07652.14 AMD19765.1 - 0.081 12.9 1.0 0.3 11.0 0.1 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain Sec3_C PF09763.9 AMD19765.1 - 0.18 10.2 4.5 0.4 9.0 4.5 1.5 1 0 0 1 1 1 0 Exocyst complex component Sec3 SAM35 PF10806.8 AMD19766.1 - 1.3e-32 112.7 0.3 2.2e-32 112.0 0.3 1.4 1 0 0 1 1 1 1 SAM35, subunit of SAM coomplex STE PF02200.16 AMD19767.1 - 8e-60 200.1 1.6 1.2e-59 199.5 1.6 1.3 1 0 0 1 1 1 1 STE like transcription factor RXT2_N PF08595.11 AMD19767.1 - 1.7 8.7 10.9 0.38 10.8 2.0 2.8 2 0 0 2 2 2 0 RXT2-like, N-terminal Tcf25 PF04910.14 AMD19768.1 - 3.4e-70 236.9 1.1 5.1e-70 236.3 1.1 1.3 1 0 0 1 1 1 1 Transcriptional repressor TCF25 ANAPC3 PF12895.7 AMD19768.1 - 0.058 13.6 0.3 2 8.7 0.1 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Ipi1_N PF12333.8 AMD19769.1 - 3.9e-23 82.0 2.2 9.4e-23 80.8 1.0 2.3 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation Dsl1_C PF11989.8 AMD19769.1 - 0.015 15.0 0.7 0.04 13.6 0.3 1.9 2 1 0 2 2 2 0 Retrograde transport protein Dsl1 C terminal CTD_bind PF04818.13 AMD19769.1 - 0.029 15.2 0.1 0.13 13.1 0.1 2.1 1 0 0 1 1 1 0 RNA polymerase II-binding domain. RRM_1 PF00076.22 AMD19770.1 - 1e-44 150.2 0.1 4.2e-17 61.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD19770.1 - 2e-05 24.6 0.1 0.046 13.8 0.0 3.7 3 0 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 AMD19770.1 - 0.0065 16.5 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 AMD19770.1 - 0.0084 16.1 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 AMD19770.1 - 0.013 15.3 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif API5 PF05918.11 AMD19770.1 - 0.36 9.6 8.9 0.55 9.0 8.9 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) eIF-3_zeta PF05091.12 AMD19770.1 - 0.43 9.5 4.6 0.62 9.0 4.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) zf-C2H2 PF00096.26 AMD19771.1 - 1e-08 35.2 11.0 0.00024 21.4 2.4 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD19771.1 - 6.4e-06 26.6 8.4 0.0075 17.0 1.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AMD19771.1 - 0.00022 21.5 1.1 0.00022 21.5 1.1 2.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.7 AMD19771.1 - 0.0043 17.4 2.4 0.22 12.0 0.4 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD19771.1 - 0.046 14.0 2.3 0.55 10.6 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 AMD19771.1 - 0.092 13.4 0.0 0.44 11.2 0.0 2.1 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 AMD19771.1 - 8.3 6.3 7.2 0.52 10.1 0.7 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain SNF2_N PF00176.23 AMD19772.1 - 1.8e-66 224.3 0.2 3.3e-66 223.4 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD19772.1 - 1e-18 67.7 0.0 1.1e-17 64.4 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 AMD19772.1 - 9.9e-16 57.8 10.5 4.9e-15 55.6 10.5 2.3 1 0 0 1 1 1 1 HSA ResIII PF04851.15 AMD19772.1 - 2.4e-12 47.2 0.0 1.1e-11 45.1 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AMD19772.1 - 2.5e-06 27.4 0.0 1.1e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase RhoGEF PF00621.20 AMD19773.1 - 2.7e-10 40.8 0.1 4.8e-10 40.0 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain Brix PF04427.18 AMD19774.1 - 2.2e-27 96.5 0.8 3.8e-27 95.7 0.8 1.4 1 0 0 1 1 1 1 Brix domain 7TM_transglut PF14402.6 AMD19774.1 - 0.044 13.3 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase DUF5356 PF17309.2 AMD19774.1 - 0.072 13.1 2.4 0.14 12.2 2.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5356) DUF359 PF04019.12 AMD19774.1 - 0.21 11.2 1.9 0.41 10.3 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF359) Xpo1 PF08389.12 AMD19775.1 - 0.041 13.9 5.5 3.8 7.6 0.2 3.7 3 0 0 3 3 3 0 Exportin 1-like protein MMR_HSR1 PF01926.23 AMD19776.1 - 1.2e-17 64.0 0.0 1e-16 61.0 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD19776.1 - 2.5e-07 30.8 0.0 1.6e-05 24.9 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 AMD19776.1 - 5.1e-07 29.4 0.0 5e-06 26.2 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AMD19776.1 - 1.2e-05 24.8 0.1 5.8e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 AMD19776.1 - 1.7e-05 25.0 0.1 0.13 12.3 0.0 2.8 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 AMD19776.1 - 0.00035 20.2 0.1 0.00062 19.3 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 AMD19776.1 - 0.0075 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Septin FAS_meander PF17951.1 AMD19776.1 - 0.039 13.8 0.1 0.071 12.9 0.1 1.3 1 0 0 1 1 1 0 Fatty acid synthase meander beta sheet domain Ploopntkinase3 PF18751.1 AMD19776.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Gar1 PF04410.14 AMD19777.1 - 4.9e-39 133.6 0.0 6e-39 133.3 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Ribosomal_S15 PF00312.22 AMD19778.1 - 7.6e-29 99.8 0.4 7.6e-29 99.8 0.4 2.5 3 0 0 3 3 3 1 Ribosomal protein S15 DUF4093 PF13331.6 AMD19778.1 - 0.074 13.5 0.2 0.22 12.0 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) Tli4_N PF18443.1 AMD19778.1 - 0.65 10.4 4.4 0.67 10.3 0.8 2.3 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain Abhydrolase_1 PF00561.20 AMD19779.1 - 7.5e-39 133.9 0.0 1.2e-38 133.2 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 AMD19779.1 - 0.0079 15.9 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 AMD19779.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 ING PF12998.7 AMD19780.1 - 8.5e-18 64.8 4.5 1.6e-17 64.0 4.5 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 AMD19780.1 - 1.1e-06 28.4 9.0 1.9e-06 27.7 9.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 AMD19780.1 - 0.0027 17.9 3.0 0.0071 16.6 3.0 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain FAST_2 PF08368.12 AMD19780.1 - 0.079 13.8 0.1 0.2 12.5 0.1 1.7 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 Phage_min_cap2 PF06152.11 AMD19780.1 - 0.52 9.2 4.6 0.4 9.5 0.9 2.2 2 0 0 2 2 2 0 Phage minor capsid protein 2 NifU_N PF01592.16 AMD19781.1 - 5.8e-58 194.6 0.0 7e-58 194.3 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 AMD19781.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 TSCPD domain RNA_pol_Rpb8 PF03870.15 AMD19782.1 - 1.4e-44 151.6 0.0 1.6e-44 151.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 AMD19782.1 - 0.0057 16.7 0.2 1.3 9.1 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G DUF5045 PF16464.5 AMD19782.1 - 0.023 15.0 0.2 0.7 10.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5045) DUF2407_C PF13373.6 AMD19783.1 - 2.2e-37 128.4 1.3 3.5e-37 127.7 0.6 1.7 2 0 0 2 2 2 1 DUF2407 C-terminal domain DUF2407 PF10302.9 AMD19783.1 - 1.3e-15 57.8 1.8 2.3e-13 50.6 1.8 2.3 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Deltameth_res PF16020.5 AMD19783.1 - 0.027 14.4 0.0 0.064 13.1 0.0 1.6 1 0 0 1 1 1 0 Deltamethrin resistance TMEM65 PF10507.9 AMD19783.1 - 0.031 14.2 0.7 0.17 11.8 0.1 2.2 2 0 0 2 2 2 0 Transmembrane protein 65 Mito_carr PF00153.27 AMD19784.1 - 6.3e-64 211.9 0.1 8.9e-24 83.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein AAA_lid_7 PF17867.1 AMD19785.1 - 0.0052 17.0 0.0 0.045 14.0 0.0 2.4 2 1 1 3 3 3 1 Midasin AAA lid domain Acyl_transf_1 PF00698.21 AMD19785.1 - 0.0058 16.2 0.0 0.012 15.2 0.0 1.5 1 1 0 1 1 1 1 Acyl transferase domain Zn_clus PF00172.18 AMD19786.1 - 0.00011 22.2 12.8 0.00024 21.1 12.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CtaG_Cox11 PF04442.14 AMD19787.1 - 4.7e-61 205.2 0.1 7e-61 204.7 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Ribosomal_L5e PF17144.4 AMD19788.1 - 2.2e-82 274.9 0.7 3.1e-82 274.4 0.0 1.6 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 AMD19788.1 - 4e-33 114.2 3.7 4e-33 114.2 3.7 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.6 AMD19788.1 - 0.011 15.9 0.3 0.86 9.9 0.0 2.8 3 0 0 3 3 3 0 Threonine synthase N terminus Ribosomal_L18p PF00861.22 AMD19788.1 - 0.027 14.8 0.6 0.076 13.4 0.0 1.9 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast SPT6_acidic PF14632.6 AMD19788.1 - 2.3 8.8 5.6 6.7 7.4 5.6 1.8 1 1 0 1 1 1 0 Acidic N-terminal SPT6 DPPIV_N PF00930.21 AMD19789.1 - 9.3e-87 291.1 6.0 1.4e-86 290.5 6.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 AMD19789.1 - 1.3e-45 155.5 0.3 2.7e-45 154.4 0.3 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family PAF-AH_p_II PF03403.13 AMD19789.1 - 0.0037 15.8 0.0 0.091 11.3 0.0 2.2 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II AXE1 PF05448.12 AMD19789.1 - 0.058 12.0 0.0 4.1 6.0 0.1 2.3 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 AMD19789.1 - 0.08 13.5 0.0 0.27 11.8 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family ARID PF01388.21 AMD19790.1 - 5.6e-14 52.6 0.0 5.6e-14 52.6 0.0 3.1 3 0 0 3 3 3 1 ARID/BRIGHT DNA binding domain Caldesmon PF02029.15 AMD19790.1 - 0.092 11.5 47.8 0.17 10.7 47.8 1.3 1 0 0 1 1 1 0 Caldesmon Glyco_transf_34 PF05637.12 AMD19791.1 - 1.7e-72 244.0 0.0 2e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family TPR_1 PF00515.28 AMD19792.1 - 2.2e-20 71.5 2.1 3.9e-07 29.6 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 AMD19792.1 - 3e-20 70.6 2.9 4.6e-06 26.3 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 AMD19792.1 - 8.4e-16 57.3 0.8 4.9e-05 23.8 0.2 4.9 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 AMD19792.1 - 2.4e-15 55.9 0.9 6.4e-06 25.8 0.1 5.0 3 1 2 5 5 5 3 TPR repeat TPR_17 PF13431.6 AMD19792.1 - 8.1e-13 47.8 0.8 0.035 14.5 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 AMD19792.1 - 1.3e-12 48.1 0.1 6e-06 26.8 0.6 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 AMD19792.1 - 1.7e-12 47.7 0.9 0.0017 18.9 0.1 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 AMD19792.1 - 2.1e-10 40.6 0.1 5.8e-05 23.1 0.1 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 AMD19792.1 - 2.3e-10 39.9 1.9 0.014 15.6 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 AMD19792.1 - 2.4e-07 31.0 1.0 0.04 14.2 0.0 4.2 3 2 1 4 4 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 AMD19792.1 - 6.4e-06 26.4 4.0 0.028 14.7 0.1 4.0 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 AMD19792.1 - 0.00016 21.5 0.0 0.96 9.6 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 AMD19792.1 - 0.0017 18.9 0.4 34 5.4 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 AMD19792.1 - 0.0019 17.5 0.1 0.034 13.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 AMD19792.1 - 0.0062 16.4 3.3 0.44 10.5 0.3 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD19792.1 - 0.022 15.0 1.2 0.084 13.1 0.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 AMD19792.1 - 0.18 11.9 1.8 7.6 6.7 0.0 3.3 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 AMD19792.1 - 1.4 9.1 4.7 1.8 8.7 0.2 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DEAD PF00270.29 AMD19793.1 - 1.1e-46 158.7 0.0 3.2e-45 154.0 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19793.1 - 3.6e-30 104.6 0.1 2.6e-29 101.8 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD19793.1 - 0.00059 19.9 0.0 0.0014 18.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Torus PF16131.5 AMD19794.1 - 1.1e-33 116.2 0.8 2.8e-33 114.9 0.0 2.0 2 0 0 2 2 2 1 Torus domain RRM_1 PF00076.22 AMD19794.1 - 5.1e-06 26.2 0.2 1.1e-05 25.1 0.2 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AMD19794.1 - 0.075 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PAP_RNA-bind PF04926.15 AMD19794.1 - 0.11 12.1 1.4 0.28 10.8 1.4 1.8 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain RRM_occluded PF16842.5 AMD19794.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif zf_CCCH_4 PF18345.1 AMD19794.1 - 1.3 9.2 9.5 0.32 11.1 6.3 1.7 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_4 PF18044.1 AMD19794.1 - 2.5 8.0 8.0 5.3 7.0 8.0 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger Pyrophosphatase PF00719.19 AMD19795.1 - 2.3e-57 193.3 0.1 3e-57 192.9 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase PRAI PF00697.22 AMD19796.1 - 1.4e-58 197.9 0.0 1.6e-58 197.7 0.0 1.0 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Z1 PF10593.9 AMD19796.1 - 0.037 13.5 0.0 0.048 13.2 0.0 1.1 1 0 0 1 1 1 0 Z1 domain Histone PF00125.24 AMD19797.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 AMD19797.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 AMD19797.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 AMD19797.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 AMD19797.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 AMD19797.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 AMD19798.1 - 2.6e-09 37.2 0.1 3.2e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 AMD19798.1 - 2.8e-05 24.5 0.1 3.2e-05 24.3 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AMD19798.1 - 4.6e-05 23.5 0.2 6.8e-05 23.0 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 AMD19798.1 - 8.8e-05 22.7 0.1 0.00016 21.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 AMD19798.1 - 0.0002 21.6 0.1 0.00027 21.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 AMD19798.1 - 0.0039 17.3 0.0 0.0046 17.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 AMD19798.1 - 0.0073 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 AMD19798.1 - 0.044 14.3 0.1 0.075 13.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A Tcp11 PF05794.13 AMD19799.1 - 4.2e-138 461.2 0.4 4.2e-138 461.2 0.4 1.7 2 0 0 2 2 2 1 T-complex protein 11 MRP-S24 PF14955.6 AMD19799.1 - 0.16 11.9 0.3 1.6 8.7 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S24 Sel1 PF08238.12 AMD19800.1 - 2.6e-06 27.9 7.0 7.9e-06 26.4 0.3 3.1 3 0 0 3 3 3 2 Sel1 repeat Maf1 PF09174.10 AMD19801.1 - 1.7e-42 145.5 5.7 1.1e-39 136.4 5.7 2.6 1 1 0 1 1 1 1 Maf1 regulator Rad51 PF08423.11 AMD19802.1 - 7.2e-48 163.1 0.0 1.2e-41 142.6 0.0 2.3 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 AMD19802.1 - 2.5e-08 33.7 0.0 5.1e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 AMD19802.1 - 1.3e-05 24.7 0.2 3.9e-05 23.1 0.2 1.8 1 1 0 1 1 1 1 KaiC CobU PF02283.16 AMD19802.1 - 0.00048 19.7 0.2 0.0056 16.3 0.2 2.3 1 1 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase RecA PF00154.21 AMD19802.1 - 0.0014 18.1 0.3 0.0059 16.1 0.3 2.0 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_24 PF13479.6 AMD19802.1 - 0.0058 16.4 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain FliD_N PF02465.18 AMD19802.1 - 0.11 13.2 7.0 1.4 9.7 4.9 2.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Aldedh PF00171.22 AMD19803.1 - 8e-163 542.2 0.2 9.1e-163 542.0 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 AMD19803.1 - 0.0016 17.9 0.1 0.0088 15.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) Nab2 PF11517.8 AMD19804.1 - 1e-42 144.5 1.1 1.9e-42 143.7 1.1 1.4 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.6 AMD19804.1 - 1e-19 70.2 63.4 1.7e-05 25.1 3.7 6.5 6 0 0 6 6 6 6 RNA-binding, Nab2-type zinc finger Nab2p_Zf1 PF18260.1 AMD19804.1 - 5.1e-16 58.2 8.2 5.1e-16 58.2 8.2 2.8 2 0 0 2 2 2 1 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 DUF2508 PF10704.9 AMD19804.1 - 0.13 12.4 0.1 0.37 11.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) Imm19 PF15563.6 AMD19804.1 - 0.18 11.3 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 19 DUF5542 PF17696.1 AMD19804.1 - 2.4 8.3 4.0 5.7 7.1 4.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5542) Ribosomal_S5 PF00333.20 AMD19805.1 - 2.7e-26 91.3 3.3 1.4e-25 89.0 1.9 2.4 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 AMD19805.1 - 2.7e-22 78.0 0.0 4.8e-22 77.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain SICA_alpha PF12887.7 AMD19806.1 - 0.0083 16.0 0.8 0.012 15.6 0.8 1.2 1 0 0 1 1 1 1 SICA extracellular alpha domain DUF4248 PF14053.6 AMD19806.1 - 0.12 12.4 0.2 0.37 10.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) DUF883 PF05957.13 AMD19806.1 - 0.48 11.1 2.9 2.8 8.6 2.3 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Mon1 PF03164.14 AMD19807.1 - 6.6e-131 437.1 0.4 9.2e-131 436.6 0.4 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Cas_Cmr5 PF09701.10 AMD19807.1 - 0.052 13.8 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cmr5) CPV_Polyhedrin PF17515.2 AMD19807.1 - 0.074 12.4 0.2 0.18 11.1 0.1 1.6 2 0 0 2 2 2 0 Cypovirus polyhedrin GATA PF00320.27 AMD19808.1 - 1.6e-10 40.4 4.1 2.7e-10 39.7 4.1 1.4 1 0 0 1 1 1 1 GATA zinc finger Zn_peptidase_2 PF04298.12 AMD19808.1 - 0.056 12.8 0.1 0.18 11.2 0.0 1.9 2 1 0 2 2 2 0 Putative neutral zinc metallopeptidase DNA_pol3_alpha PF07733.12 AMD19808.1 - 0.089 12.4 0.3 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial DNA polymerase III alpha NTPase domain Glyco_hydro_31 PF01055.26 AMD19809.1 - 3.5e-128 428.5 0.4 5.6e-128 427.9 0.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 AMD19809.1 - 2.2e-19 69.5 0.2 1.5e-18 66.9 0.0 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 AMD19809.1 - 2.5e-07 30.9 0.5 2.5e-06 27.7 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF5110) GIY-YIG PF01541.24 AMD19810.1 - 2.1e-11 44.0 0.0 4e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain DZR PF12773.7 AMD19810.1 - 0.053 13.6 1.5 0.48 10.5 1.5 2.2 1 1 0 1 1 1 0 Double zinc ribbon MTHFR PF02219.17 AMD19811.1 - 7.3e-117 389.8 0.0 9.9e-117 389.3 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Tyr-DNA_phospho PF06087.12 AMD19812.1 - 3.3e-82 276.6 0.0 3.8e-82 276.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 AMD19812.1 - 0.015 15.2 0.0 0.25 11.2 0.0 2.5 2 0 0 2 2 2 0 PLD-like domain AMP-binding PF00501.28 AMD19813.1 - 3e-77 260.0 0.0 8.9e-77 258.4 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 AMD19813.1 - 1.3e-17 64.5 0.1 3.1e-17 63.3 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF281 PF03436.13 AMD19813.1 - 0.068 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF281) RTX_C PF08339.10 AMD19813.1 - 0.11 12.5 0.1 1.1 9.3 0.0 2.5 2 1 0 2 2 2 0 RTX C-terminal domain Transket_pyr PF02779.24 AMD19814.1 - 1.1e-47 162.0 0.1 2.2e-47 161.0 0.1 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AMD19814.1 - 2e-37 127.9 0.0 4.2e-37 126.8 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain Acatn PF13000.7 AMD19815.1 - 4.6e-248 824.2 12.1 5.2e-248 824.0 12.1 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Scs3p PF10261.9 AMD19816.1 - 1.2e-60 205.1 13.4 1.5e-60 204.7 13.4 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Med31 PF05669.12 AMD19817.1 - 1.8e-24 85.5 1.7 2.3e-24 85.2 1.7 1.2 1 0 0 1 1 1 1 SOH1 CPSase_L_D2 PF02786.17 AMD19818.1 - 7.5e-83 277.2 0.4 1.3e-82 276.4 0.4 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 AMD19818.1 - 2e-67 226.8 0.0 3.3e-67 226.1 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 AMD19818.1 - 2.4e-39 134.3 0.0 5.1e-39 133.2 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AMD19818.1 - 8.1e-31 106.3 0.0 3.1e-30 104.5 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 AMD19818.1 - 1.2e-23 84.1 0.0 2.6e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 AMD19818.1 - 1.3e-19 69.8 10.2 2.1e-19 69.1 4.6 3.1 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 AMD19818.1 - 1.4e-08 34.6 0.0 2.8e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AMD19818.1 - 1.9e-07 30.8 0.8 4.4e-07 29.6 0.1 1.9 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 AMD19818.1 - 1.5e-06 28.0 5.8 0.013 15.3 0.3 3.4 3 1 1 4 4 4 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 AMD19818.1 - 3e-06 27.4 0.0 8.2e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 AMD19818.1 - 0.00063 19.4 0.2 0.0017 18.0 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain HlyD_D23 PF16576.5 AMD19818.1 - 0.00095 18.4 2.8 0.23 10.6 0.2 2.8 2 1 1 3 3 3 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 AMD19818.1 - 0.01 15.1 0.0 0.03 13.6 0.0 1.7 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.6 AMD19818.1 - 0.031 14.0 0.5 0.14 11.9 0.1 2.2 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon RnfC_N PF13375.6 AMD19818.1 - 0.081 12.9 2.3 0.22 11.5 0.9 2.5 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.6 AMD19818.1 - 0.16 12.6 6.4 10 6.9 0.0 4.0 4 0 0 4 4 4 0 HlyD family secretion protein DASH_Duo1 PF08651.10 AMD19819.1 - 1.7e-22 79.0 0.6 1.7e-22 79.0 0.6 1.8 2 0 0 2 2 2 1 DASH complex subunit Duo1 DHC_N2 PF08393.13 AMD19819.1 - 0.045 12.8 1.4 0.12 11.4 1.2 1.7 1 1 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 APG12 PF04110.13 AMD19820.1 - 5.5e-26 90.8 0.1 9e-26 90.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 zf-C3Hc3H PF13891.6 AMD19820.1 - 0.04 14.3 0.5 0.084 13.3 0.5 1.5 1 0 0 1 1 1 0 Potential DNA-binding domain Kinetochor_Ybp2 PF08568.10 AMD19821.1 - 5.9e-108 362.0 14.6 6.8e-108 361.8 14.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin HUN PF08729.10 AMD19822.1 - 3.2e-08 33.4 0.0 9.5e-08 31.9 0.0 1.9 1 0 0 1 1 1 1 HPC2 and ubinuclein domain TFIIA PF03153.13 AMD19822.1 - 0.043 13.8 23.2 0.061 13.3 23.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BCDHK_Adom3 PF10436.9 AMD19823.1 - 5.4e-25 88.1 1.1 8.8e-25 87.4 0.7 1.5 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AMD19823.1 - 4.3e-06 27.2 0.0 0.073 13.6 0.0 2.3 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FAST_1 PF06743.15 AMD19823.1 - 0.025 14.5 0.4 0.084 12.8 0.4 1.9 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 UQ_con PF00179.26 AMD19824.1 - 6.3e-51 171.7 0.1 7.2e-51 171.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AMD19824.1 - 0.011 15.5 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 AMD19824.1 - 0.029 14.7 0.1 0.061 13.6 0.1 1.7 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 AMD19824.1 - 0.056 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 UEV domain Leuk-A4-hydro_C PF09127.11 AMD19824.1 - 0.056 13.5 0.1 0.8 9.8 0.1 2.1 1 1 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal CBS PF00571.28 AMD19826.1 - 1.3e-21 76.8 1.8 3.7e-06 27.3 0.0 5.3 5 0 0 5 5 5 5 CBS domain Miga PF10265.9 AMD19826.1 - 0.011 14.7 1.7 0.017 14.1 1.7 1.2 1 0 0 1 1 1 0 Mitoguardin ASCH PF04266.14 AMD19826.1 - 0.15 12.7 0.0 6.8 7.3 0.0 2.6 2 0 0 2 2 2 0 ASCH domain DUF4808 PF16066.5 AMD19826.1 - 0.38 11.3 3.6 0.95 10.0 1.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4808) FA_desaturase PF00487.24 AMD19827.1 - 9.1e-20 71.6 26.3 9.1e-20 71.6 26.3 1.8 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 AMD19827.1 - 5.7e-15 55.2 0.0 1.9e-14 53.6 0.0 2.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_7 PF13241.6 AMD19828.1 - 6e-26 90.9 0.0 1e-25 90.2 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 AMD19828.1 - 4e-11 42.4 0.5 7.4e-11 41.5 0.5 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 AMD19828.1 - 2.1e-08 33.4 0.0 3.7e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central ThiF PF00899.21 AMD19828.1 - 0.019 14.3 0.3 0.046 13.1 0.3 1.6 1 0 0 1 1 1 0 ThiF family Shikimate_DH PF01488.20 AMD19828.1 - 0.088 12.9 0.0 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 AMD19828.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1706 PF08020.11 AMD19828.1 - 0.13 12.2 0.0 0.58 10.0 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1706) Vps62 PF06101.11 AMD19829.1 - 2.4e-05 22.8 2.2 9.7e-05 20.9 2.2 1.9 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 NDC10_II PF16787.5 AMD19830.1 - 5.2e-62 209.7 4.1 1.9e-60 204.6 4.1 2.7 1 1 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 AMD19830.1 - 3.7e-20 72.0 3.3 5.8e-20 71.4 0.2 2.8 3 0 0 3 3 3 1 Transcriptional activator of glycolytic enzymes Interferon PF00143.19 AMD19830.1 - 0.054 13.7 3.6 0.18 12.0 3.6 1.9 1 1 0 1 1 1 0 Interferon alpha/beta domain NCA2 PF08637.10 AMD19831.1 - 2.8e-89 299.1 1.7 4.2e-89 298.5 1.7 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 NS3 PF17530.2 AMD19831.1 - 0.098 12.2 0.1 0.22 11.1 0.1 1.5 1 0 0 1 1 1 0 Non-structural protein NS3 SH3_1 PF00018.28 AMD19832.1 - 5.9e-16 57.8 0.0 8.9e-16 57.2 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AMD19832.1 - 4.4e-11 42.4 0.0 7.8e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AMD19832.1 - 5.2e-10 38.9 0.0 7.9e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Pex14_N PF04695.13 AMD19832.1 - 0.022 15.4 12.5 4.1 8.0 9.8 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tmemb_170 PF10190.9 AMD19833.1 - 1.1e-18 67.6 11.7 1.4e-18 67.2 11.7 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF1129 PF06570.11 AMD19833.1 - 0.12 11.9 0.4 0.14 11.6 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Proteasome PF00227.26 AMD19834.1 - 2.7e-58 196.6 0.2 3.3e-58 196.3 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AMD19834.1 - 4.8e-12 45.3 0.9 8.1e-12 44.6 0.2 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RuvA_C PF07499.13 AMD19834.1 - 0.11 13.0 2.7 0.5 10.9 0.1 3.1 4 0 0 4 4 4 0 RuvA, C-terminal domain FF PF01846.19 AMD19835.1 - 2.5e-09 37.2 7.2 3.4e-08 33.5 0.3 3.7 3 1 1 4 4 4 2 FF domain WW PF00397.26 AMD19835.1 - 2.7e-09 36.9 2.2 6.5e-09 35.7 2.2 1.7 1 0 0 1 1 1 1 WW domain SDA1 PF05285.12 AMD19835.1 - 0.14 11.6 9.5 0.19 11.2 9.5 1.1 1 0 0 1 1 1 0 SDA1 PBD PF00786.28 AMD19835.1 - 0.26 11.7 1.7 0.47 10.8 0.0 2.4 3 0 0 3 3 3 0 P21-Rho-binding domain Pet20 PF08692.10 AMD19837.1 - 2.8e-05 24.8 0.0 3.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial protein Pet20 UQ_con PF00179.26 AMD19838.1 - 8.2e-38 129.2 0.1 9.1e-38 129.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 AMD19838.1 - 0.02 14.8 0.9 0.028 14.3 0.9 1.5 1 1 0 1 1 1 0 UEV domain Band_7 PF01145.25 AMD19839.1 - 5.7e-23 81.8 3.3 9.6e-23 81.1 3.3 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family Choline_kinase PF01633.20 AMD19839.1 - 0.079 12.5 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase MARVEL PF01284.23 AMD19840.1 - 5.5e-26 91.3 13.7 6.8e-26 91.0 13.7 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.12 AMD19840.1 - 0.033 14.0 6.0 0.16 11.7 6.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF588) SNN_transmemb PF09049.10 AMD19840.1 - 0.63 10.0 4.4 7.3 6.6 0.1 2.4 2 0 0 2 2 2 0 Stannin transmembrane DDE_Tnp_1 PF01609.21 AMD19841.1 - 0.13 11.9 3.0 0.42 10.2 2.7 2.1 1 1 0 1 1 1 0 Transposase DDE domain BAR_2 PF10455.9 AMD19842.1 - 1.4e-90 303.4 11.9 1.4e-90 303.4 11.9 1.3 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 AMD19842.1 - 0.00028 20.6 22.1 0.0032 17.2 12.7 3.5 2 2 1 3 3 3 2 BAR domain DUF4446 PF14584.6 AMD19842.1 - 0.015 15.3 1.0 0.015 15.3 1.0 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) Herpes_UL6 PF01763.16 AMD19842.1 - 0.062 11.8 10.4 0.0054 15.3 3.0 2.2 2 0 0 2 2 2 0 Herpesvirus UL6 like P4Ha_N PF08336.11 AMD19842.1 - 0.5 10.4 5.9 1.4 9.0 0.9 3.1 2 1 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region HIP1_clath_bdg PF16515.5 AMD19842.1 - 1.9 9.1 12.2 4.4 8.0 1.6 3.0 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TINF2_N PF14973.6 AMD19842.1 - 2.3 8.6 8.9 10 6.5 1.6 2.9 2 1 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus NOA36 PF06524.12 AMD19842.1 - 7.7 5.7 11.9 0.15 11.3 3.1 2.1 2 0 0 2 2 2 0 NOA36 protein SYF2 PF08231.12 AMD19843.1 - 3.8e-09 37.2 10.7 3.8e-09 37.2 10.7 2.2 1 1 1 2 2 2 1 SYF2 splicing factor Utp8 PF10395.9 AMD19844.1 - 2.7e-203 677.3 25.1 3.6e-203 676.9 25.1 1.1 1 0 0 1 1 1 1 Utp8 family DUF573 PF04504.14 AMD19844.1 - 0.00011 22.7 3.7 0.0064 17.1 0.5 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF573 LIDHydrolase PF10230.9 AMD19845.1 - 2.8e-66 223.8 0.2 3.3e-66 223.6 0.2 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 AMD19845.1 - 0.0042 17.0 0.0 0.07 13.0 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase Peptidase_S9 PF00326.21 AMD19845.1 - 0.024 14.1 0.0 0.061 12.8 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family PUF PF00806.19 AMD19845.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat PGAP1 PF07819.13 AMD19845.1 - 0.33 10.6 5.9 0.81 9.4 3.8 2.6 2 1 0 2 2 2 0 PGAP1-like protein TANGO2 PF05742.12 AMD19846.1 - 4.6e-59 200.5 0.0 5.3e-59 200.3 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Sulfate_transp PF00916.20 AMD19847.1 - 1.1e-68 231.7 15.9 1.7e-68 231.1 15.9 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 AMD19847.1 - 1.4e-12 47.3 0.5 2.5e-12 46.5 0.5 1.4 1 0 0 1 1 1 1 STAS domain cNMP_binding PF00027.29 AMD19847.1 - 0.068 13.3 0.0 0.19 11.8 0.0 1.8 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain DUF4044 PF13253.6 AMD19847.1 - 0.97 9.0 2.9 0.94 9.0 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) Pkinase PF00069.25 AMD19848.1 - 4.2e-50 170.6 0.0 1e-41 143.1 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19848.1 - 5.5e-22 78.3 0.0 1.5e-18 67.1 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD19848.1 - 1.9e-06 26.9 0.0 3.3e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AMD19848.1 - 0.056 12.7 0.2 0.53 9.6 0.0 2.4 2 1 0 2 2 2 0 Kinase-like DEAD PF00270.29 AMD19849.1 - 3.9e-47 160.3 1.7 4.3e-47 160.1 0.1 1.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD19849.1 - 3.1e-25 88.7 0.0 6.2e-24 84.5 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AMD19849.1 - 3.8e-17 62.3 0.3 6.8e-17 61.5 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AMD19849.1 - 4.5e-06 26.8 0.1 8.3e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AMD19849.1 - 9.1e-05 21.8 0.0 0.00029 20.1 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 AMD19849.1 - 0.0017 17.7 0.0 0.0029 16.9 0.0 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain SAM_LFY PF01698.16 AMD19849.1 - 0.11 12.4 0.0 0.42 10.6 0.0 2.0 1 0 0 1 1 1 0 Floricaula / Leafy protein SAM domain AAA_30 PF13604.6 AMD19849.1 - 0.15 11.7 0.1 1 9.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AMD19849.1 - 0.2 11.9 1.3 0.97 9.7 1.3 2.3 1 1 0 1 1 1 0 AAA domain tRNA-synt_1g PF09334.11 AMD19850.1 - 3.8e-154 513.2 0.1 5e-154 512.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.10 AMD19850.1 - 7.2e-38 129.9 0.2 1.3e-37 129.0 0.2 1.5 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1 PF00133.22 AMD19850.1 - 4.5e-10 38.4 0.4 0.00038 18.8 0.0 3.0 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AMD19850.1 - 0.075 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Kdo PF06293.14 AMD19851.1 - 4.4e-08 32.7 0.0 6.6e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD19851.1 - 9.7e-05 22.4 0.0 0.0046 16.9 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 AMD19851.1 - 0.0052 16.2 0.0 0.0064 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD19851.1 - 0.047 13.0 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase DUF1679 PF07914.11 AMD19851.1 - 0.16 10.8 0.0 0.3 9.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Aminotran_4 PF01063.19 AMD19852.1 - 2.3e-16 60.4 0.0 7.3e-16 58.7 0.0 1.7 1 1 0 1 1 1 1 Amino-transferase class IV Erv26 PF04148.13 AMD19853.1 - 4.2e-77 258.6 6.4 5e-77 258.4 6.4 1.1 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF996 PF06195.13 AMD19853.1 - 0.0078 16.5 1.2 0.0078 16.5 1.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF996) PhoR PF11808.8 AMD19853.1 - 5.8 7.4 10.4 0.79 10.2 0.6 2.9 2 1 1 3 3 3 0 Phosphate regulon sensor protein PhoR RhoGAP PF00620.27 AMD19854.1 - 0.085 12.7 0.0 0.37 10.6 0.0 2.1 1 1 0 1 1 1 0 RhoGAP domain DUF1798 PF08807.10 AMD19854.1 - 1.4 9.1 7.6 0.2 11.8 1.8 2.3 2 0 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) 6PGD PF00393.19 AMD19855.1 - 8.6e-124 412.6 0.0 1.1e-123 412.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 AMD19855.1 - 2e-51 174.3 0.0 3e-51 173.7 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 AMD19855.1 - 0.0019 18.7 0.2 0.0036 17.9 0.2 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 AMD19855.1 - 0.015 14.6 0.1 0.037 13.4 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 AMD19855.1 - 0.062 13.5 0.0 0.3 11.3 0.0 2.1 3 0 0 3 3 3 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Mito_carr PF00153.27 AMD19857.1 - 6.3e-60 199.1 2.7 3.1e-23 81.5 0.1 3.5 2 1 1 3 3 3 3 Mitochondrial carrier protein XPG_N PF00752.17 AMD19859.1 - 4.7e-34 116.9 0.0 1.1e-33 115.8 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AMD19859.1 - 8e-26 90.2 0.0 2.5e-25 88.7 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 AMD19859.1 - 3.6e-06 26.6 0.1 1.5e-05 24.6 0.1 2.0 1 1 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 AMD19859.1 - 3e-05 24.5 0.0 0.00012 22.6 0.0 2.0 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 AMD19859.1 - 0.03 14.6 0.0 0.07 13.5 0.0 1.6 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family Fasciclin PF02469.22 AMD19860.1 - 1.6e-07 31.6 0.0 3.4e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Fasciclin domain HLH PF00010.26 AMD19861.1 - 9.3e-19 67.1 1.0 9.3e-19 67.1 1.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF2247 PF10004.9 AMD19861.1 - 0.046 13.5 1.2 0.1 12.3 1.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) XPG_N PF00752.17 AMD19862.1 - 7.4e-24 84.2 0.0 1.9e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AMD19862.1 - 2.3e-21 75.9 0.0 5.6e-21 74.7 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 AMD19862.1 - 0.013 16.1 0.0 0.036 14.6 0.0 1.8 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 AMD19862.1 - 0.038 14.1 0.0 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix motif XPG_I_2 PF12813.7 AMD19862.1 - 0.075 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 XPG domain containing TPR_8 PF13181.6 AMD19862.1 - 0.15 12.3 0.0 1.3 9.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Ank_2 PF12796.7 AMD19863.1 - 5.9e-38 129.3 2.6 7.1e-15 55.4 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AMD19863.1 - 3.4e-27 94.5 2.1 1.8e-08 34.8 0.0 5.0 2 2 3 5 5 5 4 Ankyrin repeats (many copies) DHHC PF01529.20 AMD19863.1 - 3.1e-25 88.8 3.9 3.1e-25 88.8 3.9 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_5 PF13857.6 AMD19863.1 - 2.5e-24 85.0 0.1 3.5e-09 36.7 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD19863.1 - 5.6e-23 78.5 0.1 0.00018 21.7 0.0 6.9 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 AMD19863.1 - 3.4e-22 77.9 0.9 5.6e-05 23.4 0.0 6.5 5 1 1 6 6 6 4 Ankyrin repeat UNC45-central PF11701.8 AMD19864.1 - 2.1e-22 79.7 0.5 2.1e-22 79.7 0.5 2.9 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central Cnd1 PF12717.7 AMD19864.1 - 1.8 8.6 6.2 10 6.1 0.2 4.0 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Pex2_Pex12 PF04757.14 AMD19865.1 - 1.3e-31 109.9 5.8 1.7e-31 109.6 5.8 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 AMD19865.1 - 9e-08 32.3 19.0 1.4e-07 31.7 19.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 AMD19865.1 - 7.5e-07 28.9 19.6 1.1e-06 28.4 19.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD19865.1 - 3e-05 23.8 17.0 4.9e-05 23.1 17.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD19865.1 - 8e-05 22.4 18.2 0.00013 21.8 18.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AMD19865.1 - 0.00013 22.2 14.0 0.00024 21.3 14.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 AMD19865.1 - 0.00016 21.4 19.0 0.00025 20.8 19.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 AMD19865.1 - 0.0055 16.7 11.5 0.0055 16.7 11.5 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 AMD19865.1 - 0.0082 16.1 14.7 0.024 14.6 14.9 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 AMD19865.1 - 0.021 15.0 17.7 0.039 14.1 17.7 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 AMD19865.1 - 0.041 13.9 10.2 0.068 13.2 10.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 AMD19866.1 - 5.3e-07 29.4 7.0 5.3e-07 29.4 7.0 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD19866.1 - 0.0011 18.8 8.2 0.0011 18.8 8.2 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) GLTSCR1 PF15249.6 AMD19866.1 - 0.28 11.6 3.8 2.1 8.9 0.0 2.9 3 0 0 3 3 3 0 Conserved region of unknown function on GLTSCR protein zf-RING_5 PF14634.6 AMD19866.1 - 0.74 9.8 22.7 0.039 13.9 9.3 3.4 3 0 0 3 3 3 0 zinc-RING finger domain PGP_phosphatase PF09419.10 AMD19867.1 - 5.9e-68 227.7 0.0 6.7e-68 227.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 AMD19867.1 - 4.1e-06 26.8 0.0 7e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like PhoR PF11808.8 AMD19868.1 - 1.8 9.0 0.0 1.8 9.0 0.0 2.8 2 1 1 3 3 3 0 Phosphate regulon sensor protein PhoR FAT PF02259.23 AMD19869.1 - 2.7e-72 243.9 7.9 2.6e-71 240.7 8.9 2.2 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 AMD19869.1 - 1.5e-49 169.1 1.4 4.3e-49 167.6 1.4 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 AMD19869.1 - 0.00065 19.5 0.0 0.0019 17.9 0.0 1.9 1 0 0 1 1 1 1 FATC domain PXA PF02194.15 AMD19869.1 - 0.63 10.0 7.4 1.4 8.9 0.1 4.5 4 0 0 4 4 4 0 PXA domain EMP24_GP25L PF01105.24 AMD19870.1 - 1.6e-40 139.0 0.1 1.8e-40 138.8 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Metallophos PF00149.28 AMD19871.1 - 3.1e-40 138.9 0.0 4e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AMD19871.1 - 4.2e-22 78.3 1.3 6.7e-22 77.7 0.4 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Yip1 PF04893.17 AMD19872.1 - 6.1e-09 35.8 9.5 8.5e-09 35.4 9.5 1.2 1 0 0 1 1 1 1 Yip1 domain DUF2070 PF09843.9 AMD19872.1 - 3 6.0 11.1 3.9 5.6 11.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Kelch_4 PF13418.6 AMD19873.1 - 1.2e-17 63.6 6.1 0.00044 20.2 0.0 5.7 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 AMD19873.1 - 1.9e-17 62.9 3.4 1.3e-07 31.7 0.0 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 AMD19873.1 - 3.3e-11 42.6 6.3 0.0016 17.9 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 AMD19873.1 - 3e-07 30.5 0.8 0.61 10.4 0.0 5.6 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 AMD19873.1 - 0.00035 20.4 2.0 0.087 12.8 0.0 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 AMD19873.1 - 0.0016 18.4 2.9 2.1 8.4 0.0 4.3 4 0 0 4 4 4 2 Kelch motif HEAT_EZ PF13513.6 AMD19874.1 - 1.6e-32 111.5 20.0 0.0003 21.2 0.0 17.6 16 3 3 19 19 18 6 HEAT-like repeat HEAT PF02985.22 AMD19874.1 - 1.6e-29 99.4 18.5 0.001 19.1 0.0 20.2 24 0 0 24 24 22 5 HEAT repeat HEAT_2 PF13646.6 AMD19874.1 - 1.3e-26 92.8 21.4 2.3e-05 24.7 0.4 12.9 12 2 3 15 15 13 6 HEAT repeats Gcn1_N PF12074.8 AMD19874.1 - 1.5e-20 73.8 1.8 9.3e-11 41.6 0.2 4.3 4 0 0 4 4 4 2 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Vac14_Fab1_bd PF12755.7 AMD19874.1 - 1.7e-15 57.4 0.1 0.01 16.4 0.0 10.4 8 2 1 10 10 10 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 AMD19874.1 - 6.5e-10 39.3 27.0 0.16 12.0 0.0 12.3 10 4 3 14 14 14 3 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 AMD19874.1 - 7.6e-08 32.4 13.0 2 8.3 0.0 10.1 8 2 1 9 9 9 2 Domain of unknown function (DUF3385) ParcG PF10274.9 AMD19874.1 - 0.00026 21.1 3.3 12 6.0 0.0 6.3 6 1 0 6 6 6 1 Parkin co-regulated protein RTP1_C1 PF10363.9 AMD19874.1 - 0.0045 17.2 10.9 53 4.0 0.2 8.7 9 0 0 9 9 9 0 Required for nuclear transport of RNA pol II C-terminus 1 ADSL_C PF10397.9 AMD19874.1 - 0.057 14.0 0.2 17 6.0 0.0 4.5 4 0 0 4 4 4 0 Adenylosuccinate lyase C-terminus NUC173 PF08161.12 AMD19874.1 - 0.061 13.0 5.3 7.7 6.1 0.0 6.1 7 0 0 7 7 7 0 NUC173 domain WASH-7_C PF14746.6 AMD19874.1 - 1.8 8.2 6.4 2 8.1 4.5 2.1 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal DUF1736 PF08409.11 AMD19875.1 - 0.16 12.0 4.1 0.14 12.2 3.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1736) DUF2678 PF10856.8 AMD19875.1 - 0.35 10.8 3.0 1.5 8.8 2.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2678) Hist_deacetyl PF00850.19 AMD19876.1 - 2.3e-82 276.9 0.0 3e-82 276.6 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain MT-A70 PF05063.14 AMD19877.1 - 1.2e-55 188.1 0.2 2.6e-55 187.0 0.2 1.6 1 0 0 1 1 1 1 MT-A70 ATP_synt_H PF05493.13 AMD19879.1 - 9.8e-21 74.0 3.8 1.2e-20 73.7 3.8 1.1 1 0 0 1 1 1 1 ATP synthase subunit H MFS_2 PF13347.6 AMD19879.1 - 0.007 15.0 0.6 0.0074 14.9 0.6 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein 7TM-7TMR_HD PF07698.11 AMD19879.1 - 0.016 15.0 2.3 0.018 14.8 2.3 1.0 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase Halogen_Hydrol PF10112.9 AMD19879.1 - 0.077 13.0 0.4 0.077 13.0 0.4 1.0 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Na_H_antiport_1 PF06965.12 AMD19879.1 - 0.37 9.6 4.4 0.42 9.4 4.4 1.0 1 0 0 1 1 1 0 Na+/H+ antiporter 1 UEV PF05743.13 AMD19880.1 - 4e-23 81.6 0.0 9.7e-23 80.3 0.0 1.7 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 AMD19880.1 - 2.4e-22 78.6 1.3 4e-21 74.7 0.3 2.4 2 0 0 2 2 2 1 Vps23 core domain DUF3573 PF12097.8 AMD19880.1 - 0.07 12.0 0.4 0.093 11.5 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DKCLD PF08068.12 AMD19881.1 - 4.6e-32 109.9 0.4 4.5e-31 106.7 0.5 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 AMD19881.1 - 3e-22 78.5 1.1 4.5e-22 77.9 0.3 1.8 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 AMD19881.1 - 7.2e-21 75.1 5.3 2.8e-19 70.0 0.0 3.8 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 AMD19881.1 - 8.6e-21 73.7 1.1 2.1e-20 72.4 1.1 1.7 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 AMD19881.1 - 0.0044 17.3 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 UPF0113 PUA domain GAGA_bind PF06217.12 AMD19881.1 - 0.05 13.9 19.7 0.069 13.4 19.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 AMD19881.1 - 6.7 6.4 35.3 10 5.9 35.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DnaJ_C PF01556.18 AMD19882.1 - 4.7e-37 127.3 0.0 6.2e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AMD19882.1 - 5.7e-23 80.8 0.2 8.9e-23 80.2 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain ABC_tran PF00005.27 AMD19883.1 - 3.9e-47 160.2 0.1 3.7e-22 79.3 0.0 3.1 2 1 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 AMD19883.1 - 3e-19 68.8 8.1 3e-19 68.8 8.1 3.2 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 AMD19883.1 - 2.1e-16 60.6 13.1 0.00019 21.4 2.4 5.1 3 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AMD19883.1 - 2.8e-12 46.6 0.0 1.8e-05 24.3 0.0 3.8 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 AMD19883.1 - 1.7e-07 31.6 0.2 0.024 14.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 AMD19883.1 - 2.1e-07 31.5 0.1 0.01 16.3 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 AMD19883.1 - 3.4e-07 30.6 0.4 0.059 13.6 0.0 3.4 3 1 0 3 3 2 2 AAA domain NACHT PF05729.12 AMD19883.1 - 9.5e-07 28.9 0.0 0.008 16.1 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_23 PF13476.6 AMD19883.1 - 1.6e-06 28.8 28.1 0.029 14.9 0.0 5.3 5 0 0 5 5 5 2 AAA domain AAA_29 PF13555.6 AMD19883.1 - 2.1e-06 27.3 0.0 0.11 12.2 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.6 AMD19883.1 - 2.8e-06 27.9 6.1 0.0067 17.0 0.0 3.5 4 1 0 4 4 2 2 AAA domain MMR_HSR1 PF01926.23 AMD19883.1 - 4.1e-06 26.9 1.0 0.054 13.6 0.2 3.5 2 2 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD19883.1 - 4.8e-06 26.6 0.6 0.12 12.3 0.1 3.1 2 1 1 3 3 3 2 RsgA GTPase AAA PF00004.29 AMD19883.1 - 5.8e-06 26.8 0.1 0.027 14.9 0.0 4.1 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 AMD19883.1 - 7.6e-06 26.0 0.0 0.2 11.7 0.0 3.3 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 AMD19883.1 - 9.5e-06 25.5 0.0 0.025 14.3 0.0 3.6 4 0 0 4 4 3 1 AAA domain AAA_33 PF13671.6 AMD19883.1 - 1.9e-05 24.9 0.6 0.065 13.4 0.0 3.4 3 1 0 3 3 2 1 AAA domain ATP-synt_ab PF00006.25 AMD19883.1 - 6.3e-05 22.7 0.0 0.027 14.1 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.22 AMD19883.1 - 0.00011 22.5 0.5 0.29 11.5 0.0 3.5 4 0 0 4 4 2 1 RNA helicase PduV-EutP PF10662.9 AMD19883.1 - 0.00031 20.5 0.0 0.17 11.6 0.0 2.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 AMD19883.1 - 0.00057 20.1 0.0 0.77 10.0 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 AMD19883.1 - 0.0006 19.6 0.0 1.1 8.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain NTPase_1 PF03266.15 AMD19883.1 - 0.00066 19.6 0.0 0.3 11.0 0.0 2.9 2 0 0 2 2 2 1 NTPase MeaB PF03308.16 AMD19883.1 - 0.0014 17.7 0.5 0.58 9.1 0.0 3.1 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 AMD19883.1 - 0.0014 17.8 0.9 0.82 8.8 0.0 2.9 2 1 0 2 2 2 1 NB-ARC domain MobB PF03205.14 AMD19883.1 - 0.0018 18.2 0.0 0.09 12.7 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.12 AMD19883.1 - 0.0018 17.6 0.0 0.32 10.2 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin AAA_15 PF13175.6 AMD19883.1 - 0.0022 17.7 30.3 0.01 15.5 0.0 4.2 3 1 1 4 4 2 2 AAA ATPase domain AAA_7 PF12775.7 AMD19883.1 - 0.0025 17.4 0.0 0.46 10.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region cobW PF02492.19 AMD19883.1 - 0.0034 17.0 0.4 2.7 7.6 0.0 3.0 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 AMD19883.1 - 0.0035 17.3 0.1 1.7 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF2813 PF11398.8 AMD19883.1 - 0.0036 16.6 6.4 0.21 10.8 0.0 3.8 3 1 1 4 4 4 1 Protein of unknown function (DUF2813) AAA_25 PF13481.6 AMD19883.1 - 0.0041 16.7 0.0 1.1 8.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain Ras PF00071.22 AMD19883.1 - 0.0067 16.0 1.0 6.5 6.3 0.0 3.4 3 0 0 3 3 3 0 Ras family TsaE PF02367.17 AMD19883.1 - 0.0071 16.3 0.0 0.28 11.2 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 AMD19883.1 - 0.0085 16.0 0.0 0.3 11.0 0.0 2.7 2 0 0 2 2 2 1 Rad17 P-loop domain Pox_A32 PF04665.12 AMD19883.1 - 0.0097 15.4 0.0 0.35 10.3 0.0 2.6 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_27 PF13514.6 AMD19883.1 - 0.012 15.3 0.1 5.4 6.5 0.0 3.2 3 0 0 3 3 3 0 AAA domain Seryl_tRNA_N PF02403.22 AMD19883.1 - 0.013 15.8 6.7 0.013 15.8 6.7 4.2 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF1043 PF06295.12 AMD19883.1 - 0.013 15.5 1.7 0.013 15.5 1.7 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) DUF815 PF05673.13 AMD19883.1 - 0.014 14.6 0.6 3.5 6.7 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF815) SRP54 PF00448.22 AMD19883.1 - 0.016 14.9 0.3 0.99 9.0 0.0 3.1 4 0 0 4 4 2 0 SRP54-type protein, GTPase domain FeoB_N PF02421.18 AMD19883.1 - 0.021 14.4 0.0 3.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B TrwB_AAD_bind PF10412.9 AMD19883.1 - 0.025 13.5 0.1 0.15 10.9 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Septin PF00735.18 AMD19883.1 - 0.025 13.9 4.2 3.6 6.8 0.4 3.3 3 1 0 3 3 3 0 Septin Viral_helicase1 PF01443.18 AMD19883.1 - 0.029 14.1 0.0 0.94 9.2 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase SbcCD_C PF13558.6 AMD19883.1 - 0.037 14.3 0.1 20 5.5 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_19 PF13245.6 AMD19883.1 - 0.046 14.1 0.2 0.43 10.9 0.0 2.6 3 0 0 3 3 2 0 AAA domain TniB PF05621.11 AMD19883.1 - 0.054 12.9 0.0 8.6 5.7 0.0 3.5 4 0 0 4 4 4 0 Bacterial TniB protein T2SSE PF00437.20 AMD19883.1 - 0.059 12.4 0.0 0.5 9.4 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_17 PF13207.6 AMD19883.1 - 0.15 12.5 4.3 8.4 6.8 0.0 4.1 3 1 1 4 4 3 0 AAA domain Dynamin_N PF00350.23 AMD19883.1 - 0.26 11.3 11.1 0.087 12.9 0.7 3.7 3 1 1 4 4 3 0 Dynamin family ATPase_2 PF01637.18 AMD19883.1 - 0.52 10.2 13.1 0.91 9.4 0.0 3.7 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea DUF87 PF01935.17 AMD19883.1 - 0.72 9.9 0.0 0.72 9.9 0.0 4.8 4 2 1 5 5 4 0 Helicase HerA, central domain Guanylate_kin PF00625.21 AMD19883.1 - 1 9.0 9.4 7.6 6.2 0.0 4.1 4 0 0 4 4 4 0 Guanylate kinase dNK PF01712.19 AMD19883.1 - 1.4 8.8 8.7 6 6.7 0.0 3.9 4 0 0 4 4 3 0 Deoxynucleoside kinase RNB PF00773.19 AMD19884.1 - 1.7e-98 330.0 0.1 2.5e-98 329.4 0.1 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 AMD19884.1 - 4e-65 218.0 0.2 1e-64 216.7 0.2 1.8 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 AMD19884.1 - 1.5e-27 95.4 1.1 4.1e-27 94.0 1.1 1.8 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 AMD19884.1 - 3.6e-18 65.4 0.0 9.3e-18 64.0 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 AMD19884.1 - 6.6e-15 55.5 0.3 1.7e-14 54.2 0.3 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 AMD19884.1 - 1.6e-05 25.0 0.0 0.0054 16.9 0.0 3.2 2 0 0 2 2 2 1 Cold shock domain RMI1_C PF16099.5 AMD19884.1 - 0.12 12.2 0.0 1.5 8.6 0.0 2.6 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold AA_permease PF00324.21 AMD19885.1 - 1e-125 420.1 42.6 1.3e-125 419.8 42.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD19885.1 - 4.4e-32 111.5 42.3 5.3e-32 111.2 42.3 1.1 1 0 0 1 1 1 1 Amino acid permease UCH PF00443.29 AMD19886.1 - 4.7e-50 170.5 0.9 5.8e-50 170.2 0.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD19886.1 - 3.9e-11 43.1 5.7 2.3e-09 37.3 5.7 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 AMD19886.1 - 3.7e-05 23.4 0.0 0.00017 21.2 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin family DUF2267 PF10025.9 AMD19886.1 - 0.0013 19.0 0.5 0.12 12.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2267) DUF1690 PF07956.11 AMD19887.1 - 8e-36 123.5 9.7 9e-36 123.3 9.7 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Tox-REase-2 PF15646.6 AMD19887.1 - 0.033 14.4 1.9 0.038 14.2 0.5 1.7 1 1 1 2 2 2 0 Restriction endonuclease fold toxin 2 Peptidase_C101 PF16218.5 AMD19887.1 - 0.15 11.3 4.3 0.19 11.0 4.3 1.1 1 0 0 1 1 1 0 Peptidase family C101 FlaC_arch PF05377.11 AMD19888.1 - 0.039 14.3 0.2 0.039 14.3 0.2 3.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) GPS2_interact PF15784.5 AMD19888.1 - 0.21 12.1 0.3 0.21 12.1 0.3 2.6 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain APG6_N PF17675.1 AMD19888.1 - 3.1 8.3 15.7 1.2 9.6 0.9 3.4 3 1 0 3 3 3 0 Apg6 coiled-coil region KxDL PF10241.9 AMD19888.1 - 4.5 7.6 7.3 5.9 7.2 0.2 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF4140 PF13600.6 AMD19888.1 - 4.8 7.7 7.0 0.69 10.4 0.8 2.8 3 1 1 4 4 4 0 N-terminal domain of unknown function (DUF4140) Prefoldin_2 PF01920.20 AMD19888.1 - 7.2 6.6 9.7 2.4 8.1 0.2 3.7 3 1 0 3 3 3 0 Prefoldin subunit SEN1_N PF12726.7 AMD19889.1 - 8.4e-183 609.5 6.0 8.4e-183 609.5 6.0 1.6 2 0 0 2 2 2 1 SEN1 N terminal AAA_11 PF13086.6 AMD19889.1 - 1.7e-70 237.8 1.3 1.7e-70 237.8 1.3 2.7 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 AMD19889.1 - 1.7e-63 213.8 0.1 8.6e-63 211.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AMD19889.1 - 3.6e-09 36.6 0.0 0.00015 21.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 AMD19889.1 - 1.1e-08 35.5 0.0 1.1e-07 32.2 0.0 2.6 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 AMD19889.1 - 1.8e-05 24.6 0.0 0.8 9.4 0.0 3.8 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase CCDC32 PF14989.6 AMD19889.1 - 0.012 15.6 0.2 0.034 14.1 0.2 1.8 1 0 0 1 1 1 0 Coiled-coil domain containing 32 UvrD_C_2 PF13538.6 AMD19889.1 - 0.033 14.0 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain T2SSE PF00437.20 AMD19889.1 - 0.046 12.8 0.1 0.084 11.9 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF1899 PF08953.11 AMD19890.1 - 3.6e-32 110.0 0.4 8.5e-32 108.8 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 AMD19890.1 - 3.2e-20 71.7 0.1 3.2e-20 71.7 0.1 2.8 3 0 0 3 3 3 1 Type of WD40 repeat WD40 PF00400.32 AMD19890.1 - 6e-18 64.9 4.8 0.00034 21.3 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 AMD19890.1 - 6.4e-07 28.4 0.4 0.0053 15.5 0.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 AMD19890.1 - 2.5e-05 24.5 0.0 0.27 11.5 0.0 4.3 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AMD19890.1 - 0.0083 15.1 0.0 2.3 7.1 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AMD19890.1 - 0.059 13.2 0.4 4.4 7.1 0.0 2.9 4 0 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A zf-RING_UBOX PF13445.6 AMD19891.1 - 3.3e-08 33.4 1.8 3.3e-08 33.4 1.8 1.9 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AMD19891.1 - 2.4e-07 30.5 3.1 9.3e-07 28.6 3.1 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AMD19891.1 - 4e-06 27.1 5.5 1.3e-05 25.4 5.5 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 AMD19891.1 - 4.9e-05 23.4 4.0 4.9e-05 23.4 4.0 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 AMD19891.1 - 0.00015 21.6 2.9 0.00015 21.6 2.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD19891.1 - 0.00069 19.4 8.2 0.012 15.4 8.2 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD19891.1 - 0.0032 17.4 7.8 0.011 15.7 7.8 1.9 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 AMD19891.1 - 0.012 15.4 9.5 2.5 8.0 5.8 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 FYVE PF01363.21 AMD19891.1 - 0.52 10.5 2.7 1.8 8.8 2.7 2.0 1 1 0 1 1 1 0 FYVE zinc finger zf-C3HC4_5 PF17121.5 AMD19891.1 - 0.65 9.9 3.3 0.67 9.9 0.6 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TniQ PF06527.11 AMD19891.1 - 0.83 10.4 3.3 11 6.7 0.1 3.1 3 0 0 3 3 3 0 TniQ zf-rbx1 PF12678.7 AMD19891.1 - 2.9 8.2 6.5 19 5.6 6.5 2.4 1 1 0 1 1 1 0 RING-H2 zinc finger domain SPC25 PF06703.11 AMD19892.1 - 6.6e-32 110.5 0.5 7.5e-32 110.4 0.5 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) adh_short PF00106.25 AMD19893.1 - 5.4e-28 97.8 0.0 7.9e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AMD19893.1 - 8.5e-18 64.8 0.0 1.2e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD19893.1 - 1.5e-07 31.5 0.0 2.6e-06 27.4 0.0 2.1 1 1 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 AMD19893.1 - 0.048 12.8 0.1 5.2 6.2 0.1 2.3 1 1 1 2 2 2 0 Male sterility protein CNH PF00780.22 AMD19894.1 - 1.8e-19 70.4 0.1 1.6e-18 67.3 0.1 2.1 1 1 0 1 1 1 1 CNH domain RhoGEF PF00621.20 AMD19894.1 - 8.6e-10 39.1 0.0 2.9e-09 37.4 0.0 1.9 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 AMD19894.1 - 4.7e-07 30.0 0.1 1.2e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AMD19894.1 - 0.084 13.4 0.5 1.2 9.6 0.0 3.1 3 0 0 3 3 3 0 PH domain Synaptobrevin PF00957.21 AMD19895.1 - 3.2e-15 55.7 0.7 5e-15 55.1 0.7 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 AMD19895.1 - 1.2e-10 41.3 0.0 2.2e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain CHCH PF06747.13 AMD19896.1 - 2.9e-08 33.6 2.6 5.1e-08 32.9 2.6 1.4 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 AMD19896.1 - 0.019 15.4 2.4 0.035 14.5 2.4 1.5 1 0 0 1 1 1 0 GCK domain G-patch PF01585.23 AMD19897.1 - 2.3e-14 53.0 6.3 2.2e-13 49.9 2.8 2.3 2 0 0 2 2 2 2 G-patch domain G-patch_2 PF12656.7 AMD19897.1 - 7e-08 32.5 0.3 1.5e-07 31.4 0.3 1.5 1 0 0 1 1 1 1 G-patch domain SCVP PF17619.2 AMD19897.1 - 0.034 15.0 0.0 0.099 13.5 0.0 1.7 1 0 0 1 1 1 0 Secreted clade V proteins APG17 PF04108.12 AMD19898.1 - 6.3e-84 282.4 17.3 7.2e-84 282.2 17.3 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 HNOB PF07700.15 AMD19898.1 - 0.00079 19.4 0.5 0.0041 17.1 0.0 2.3 2 0 0 2 2 2 1 Haem-NO-binding Herpes_UL36 PF03586.13 AMD19898.1 - 0.026 13.8 1.2 0.39 10.0 0.1 2.2 1 1 0 2 2 2 0 Herpesvirus UL36 tegument protein TMF_TATA_bd PF12325.8 AMD19898.1 - 0.28 11.4 18.4 0.81 9.9 4.2 3.9 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding SpecificRecomb PF10136.9 AMD19898.1 - 0.37 9.0 1.9 0.64 8.3 1.9 1.4 1 1 0 1 1 1 0 Site-specific recombinase RhoGEF PF00621.20 AMD19898.1 - 1.5 9.0 15.9 1.4 9.1 8.0 3.2 2 1 1 3 3 3 0 RhoGEF domain Phage_int_SAM_2 PF12834.7 AMD19898.1 - 3 8.6 6.1 1.3 9.7 0.1 3.1 3 1 0 3 3 3 0 Phage integrase, N-terminal DUF2203 PF09969.9 AMD19898.1 - 3.2 8.5 11.9 15 6.3 0.5 4.1 2 2 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.13 AMD19898.1 - 3.9 6.6 14.8 2.5 7.3 0.7 3.3 2 2 1 3 3 3 0 TMPIT-like protein tRNA-synt_2b PF00587.25 AMD19899.1 - 3e-44 151.1 0.0 4.9e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AMD19899.1 - 2.7e-17 62.7 0.1 5.7e-17 61.7 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain LRR_4 PF12799.7 AMD19900.1 - 3.2e-36 122.8 63.9 2.1e-09 37.5 2.0 7.1 4 1 6 10 10 10 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AMD19900.1 - 3.8e-29 100.2 34.6 7.9e-08 32.0 0.3 6.8 6 1 1 7 7 7 5 Leucine rich repeat LRR_9 PF14580.6 AMD19900.1 - 6e-18 64.9 19.8 4.7e-08 32.7 3.7 4.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 AMD19900.1 - 1.3e-08 34.2 18.9 0.039 14.0 0.1 8.6 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 AMD19900.1 - 2e-08 33.6 33.5 0.035 14.6 0.1 10.8 10 2 0 10 10 10 3 Leucine Rich Repeat Poty_PP PF08440.10 AMD19900.1 - 0.1 11.7 4.0 1.4 7.9 0.2 2.3 2 0 0 2 2 2 0 Potyviridae polyprotein LRR_5 PF13306.6 AMD19900.1 - 0.12 12.3 7.1 0.18 11.8 0.9 2.6 1 1 2 3 3 3 0 BspA type Leucine rich repeat region (6 copies) LRR_2 PF07723.13 AMD19900.1 - 0.54 11.0 8.9 42 5.0 0.4 5.2 6 0 0 6 6 6 0 Leucine Rich Repeat PP-binding PF00550.25 AMD19901.1 - 2e-11 44.1 0.5 3e-11 43.5 0.5 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 AMD19901.1 - 1.4e-05 25.2 0.7 1.9e-05 24.8 0.7 1.3 1 0 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.12 AMD19901.1 - 0.18 12.3 0.4 0.29 11.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) DHR-2 PF06920.13 AMD19902.1 - 3.3e-45 154.7 2.8 6.3e-45 153.8 1.6 2.1 2 1 0 2 2 2 1 Dock homology region 2 DOCK_N PF16172.5 AMD19902.1 - 4.3e-10 39.1 0.0 1.6e-09 37.1 0.0 1.9 1 1 0 1 1 1 1 DOCK N-terminus CinA PF02464.17 AMD19903.1 - 1.1e-30 106.2 0.0 1.3e-30 106.0 0.0 1.0 1 0 0 1 1 1 1 Competence-damaged protein DUF5333 PF17267.2 AMD19903.1 - 0.072 13.3 0.0 4.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5333) Proteasom_Rpn13 PF04683.13 AMD19904.1 - 2.2e-22 79.4 0.0 3.4e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 AMD19904.1 - 3.6e-06 27.1 0.0 4.9e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 UCH-binding domain SGT1 PF07093.11 AMD19904.1 - 0.086 11.3 0.2 0.094 11.1 0.2 1.1 1 0 0 1 1 1 0 SGT1 protein Amidohydro_1 PF01979.20 AMD19905.1 - 5.3e-08 32.5 0.0 8.1e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 AMD19905.1 - 4.8e-05 23.3 0.4 0.00019 21.3 0.0 1.9 2 1 1 3 3 3 1 Amidohydrolase Diphthamide_syn PF01866.17 AMD19906.1 - 5.5e-67 226.4 0.3 7.8e-67 225.9 0.3 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein CRAL_TRIO PF00650.20 AMD19907.1 - 2.3e-45 154.2 0.1 4.5e-45 153.2 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AMD19907.1 - 2.5e-12 46.8 2.8 2.8e-12 46.6 0.6 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AMD19907.1 - 2.9e-06 27.5 0.0 6.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain IF2_N PF04760.15 AMD19907.1 - 0.2 11.5 0.3 1.1 9.1 0.0 2.4 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region tRNA-synt_1 PF00133.22 AMD19909.1 - 1.7e-52 178.5 0.4 3.9e-31 108.0 2.7 6.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 AMD19909.1 - 5.6e-42 143.4 0.0 1.1e-41 142.4 0.0 1.5 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 AMD19909.1 - 1.5e-27 96.4 0.6 1.5e-19 70.0 0.0 4.8 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AMD19909.1 - 2.7e-08 33.9 0.0 5.8e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AMD19909.1 - 0.00018 21.0 0.0 0.04 13.3 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain DNA_ligase_ZBD PF03119.16 AMD19909.1 - 0.0095 15.9 0.1 0.037 14.1 0.0 2.1 2 0 0 2 2 2 1 NAD-dependent DNA ligase C4 zinc finger domain tRNA-synt_1d PF00750.19 AMD19909.1 - 0.012 14.6 0.0 0.027 13.4 0.0 1.5 2 0 0 2 2 2 0 tRNA synthetases class I (R) tRNA-synt_1c PF00749.21 AMD19909.1 - 0.07 12.0 0.2 4.2 6.2 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Zn-ribbon_8 PF09723.10 AMD19909.1 - 0.078 13.1 0.7 0.38 10.9 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 AMD19909.1 - 1 8.9 2.8 1 8.8 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain SMC_N PF02463.19 AMD19910.1 - 1.3e-28 99.9 3.2 5e-15 55.5 0.4 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AMD19910.1 - 5e-17 63.1 6.8 5e-17 63.1 6.8 5.1 2 2 2 4 4 2 1 AAA domain AAA_21 PF13304.6 AMD19910.1 - 1.4e-08 34.9 5.2 2.8e-05 24.1 0.4 3.1 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AMD19910.1 - 2.9e-08 33.9 39.7 2.9e-08 33.9 39.7 4.2 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 AMD19910.1 - 0.00026 20.7 0.0 0.00053 19.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain CENP-F_leu_zip PF10473.9 AMD19910.1 - 0.00038 20.5 3.9 0.00038 20.5 3.9 5.6 4 2 1 6 6 5 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 AMD19910.1 - 0.0032 17.7 10.3 0.0032 17.7 10.3 5.7 2 2 3 5 5 5 2 Autophagy protein 16 (ATG16) AAA_27 PF13514.6 AMD19910.1 - 0.016 14.8 0.0 0.016 14.8 0.0 4.2 4 1 1 5 5 5 0 AAA domain AAA_13 PF13166.6 AMD19910.1 - 0.052 12.2 67.6 0.062 11.9 22.0 5.1 3 2 1 4 4 4 0 AAA domain DUF948 PF06103.11 AMD19910.1 - 0.061 13.6 24.7 0.83 9.9 0.1 6.9 6 2 1 7 7 7 0 Bacterial protein of unknown function (DUF948) ABC_tran PF00005.27 AMD19910.1 - 0.2 12.1 0.1 0.2 12.1 0.1 5.5 3 2 0 3 3 2 0 ABC transporter MAD PF05557.13 AMD19910.1 - 1.1 7.5 73.2 0.062 11.7 14.8 3.1 2 1 0 2 2 2 0 Mitotic checkpoint protein Syntaxin-6_N PF09177.11 AMD19910.1 - 1.8 9.2 50.4 0.022 15.3 3.0 6.9 3 2 2 5 5 3 0 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.12 AMD19910.1 - 7.1 6.7 15.6 5.2 7.1 1.5 4.1 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 AMD19910.1 - 8.3 5.2 82.2 0.14 11.0 6.1 5.9 2 2 4 6 6 6 0 Spc7 kinetochore protein Uso1_p115_head PF04869.14 AMD19911.1 - 2.2e-86 289.8 5.5 2.7e-86 289.5 1.4 2.7 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 AMD19911.1 - 1.6e-05 25.3 22.4 1.6e-05 25.3 22.4 8.9 1 1 7 8 8 6 1 Uso1 / p115 like vesicle tethering protein, C terminal region Arm_vescicular PF18770.1 AMD19911.1 - 4.2e-05 23.4 0.0 0.00011 22.1 0.0 1.8 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor Spc7 PF08317.11 AMD19911.1 - 0.00029 19.8 21.3 0.00029 19.8 21.3 7.2 1 1 6 7 7 7 2 Spc7 kinetochore protein DUF4201 PF13870.6 AMD19911.1 - 0.00044 20.0 16.8 0.00044 20.0 16.8 8.0 2 1 3 6 6 6 3 Domain of unknown function (DUF4201) GAS PF13851.6 AMD19911.1 - 0.0015 17.9 151.5 0.0066 15.8 13.4 8.7 2 1 7 9 9 9 5 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 AMD19911.1 - 0.005 17.4 17.3 0.005 17.4 17.3 9.3 2 1 7 9 9 8 2 Apg6 coiled-coil region Synapsin PF02078.16 AMD19911.1 - 0.06 13.6 0.8 0.22 11.8 0.4 2.2 2 0 0 2 2 2 0 Synapsin, N-terminal domain FUSC PF04632.12 AMD19911.1 - 0.13 10.8 7.4 0.52 8.8 1.1 3.2 2 1 1 3 3 3 0 Fusaric acid resistance protein family ATG16 PF08614.11 AMD19911.1 - 0.2 11.9 131.2 0.25 11.6 28.7 6.7 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 AMD19911.1 - 0.61 10.1 154.4 0.037 14.1 24.1 8.5 2 2 7 9 9 9 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 T7SS_ESX_EspC PF10824.8 AMD19911.1 - 1.1 9.8 3.4 6.8 7.2 0.8 3.4 3 0 0 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm KASH_CCD PF14662.6 AMD19911.1 - 1.2 8.9 141.9 0.017 15.0 37.0 6.8 1 1 4 6 6 6 0 Coiled-coil region of CCDC155 or KASH TPR_MLP1_2 PF07926.12 AMD19911.1 - 2.2 8.4 147.2 0.048 13.7 17.1 9.4 3 2 3 8 8 8 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 AMD19911.1 - 8.8 3.7 114.8 0.16 9.5 42.1 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Rad52_Rad22 PF04098.15 AMD19912.1 - 5.1e-38 130.4 0.1 6e-38 130.2 0.1 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein FlgT_N PF16548.5 AMD19912.1 - 0.16 12.6 0.1 0.25 11.9 0.1 1.3 1 0 0 1 1 1 0 Flagellar assembly protein T, N-terminal domain IKI3 PF04762.12 AMD19913.1 - 0 1059.3 0.1 0 1059.0 0.1 1.1 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 AMD19913.1 - 0.00051 20.3 0.1 0.8 10.0 0.0 4.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 AMD19913.1 - 0.018 14.9 0.6 30 4.5 0.1 3.6 2 1 1 3 3 3 0 Region in Clathrin and VPS SWC7 PF17330.2 AMD19914.1 - 1.9e-33 114.4 0.7 2.5e-33 114.0 0.7 1.1 1 0 0 1 1 1 1 SWR1 chromatin-remodelling complex, sub-unit Swc7 Vac14_Fig4_bd PF11916.8 AMD19915.1 - 1.8e-64 216.7 4.3 1.8e-64 216.7 4.3 2.2 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 AMD19915.1 - 5.7e-48 161.5 3.1 1.1e-38 131.7 0.2 4.3 4 0 0 4 4 4 3 Vacuolar 14 Fab1-binding region HEAT PF02985.22 AMD19915.1 - 2.2e-14 52.3 3.2 0.00057 19.9 0.0 7.2 6 1 1 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 AMD19915.1 - 2.6e-08 34.2 2.0 0.023 15.2 0.0 6.3 5 1 1 6 6 6 1 HEAT-like repeat HEAT_2 PF13646.6 AMD19915.1 - 2e-07 31.3 0.4 0.15 12.4 0.0 5.9 5 1 1 6 6 6 1 HEAT repeats MMS19_C PF12460.8 AMD19915.1 - 2.2e-07 30.3 10.4 0.0063 15.7 1.5 4.4 4 0 0 4 4 4 3 RNAPII transcription regulator C-terminal Tti2 PF10521.9 AMD19915.1 - 2.8e-06 27.1 4.8 0.34 10.4 0.2 4.8 4 1 1 5 5 5 2 Tti2 family CLASP_N PF12348.8 AMD19915.1 - 2.4e-05 24.0 3.5 0.28 10.7 0.1 4.2 3 2 1 4 4 4 2 CLASP N terminal Adaptin_N PF01602.20 AMD19915.1 - 6.3e-05 21.7 11.1 0.00011 20.9 1.3 3.7 2 2 1 3 3 3 1 Adaptin N terminal region Cnd1 PF12717.7 AMD19915.1 - 0.00065 19.8 10.2 0.16 12.0 0.9 4.4 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 AMD19915.1 - 0.00078 19.6 4.4 0.4 10.9 0.2 4.4 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 AMD19915.1 - 0.0012 18.8 3.5 2.5 8.3 0.0 4.6 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Dopey_N PF04118.14 AMD19915.1 - 0.0036 16.5 5.9 0.0098 15.0 0.2 2.8 3 0 0 3 3 3 1 Dopey, N-terminal TAF6_C PF07571.13 AMD19915.1 - 0.005 17.1 2.0 0.077 13.3 0.1 3.2 3 0 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain RasGEF_N_2 PF14663.6 AMD19915.1 - 0.0064 16.9 8.3 0.022 15.1 0.4 4.1 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF3361 PF11841.8 AMD19915.1 - 0.0083 16.1 5.0 2.7 7.9 0.1 3.6 2 2 1 3 3 3 2 Domain of unknown function (DUF3361) TPR_22 PF18833.1 AMD19915.1 - 0.19 11.9 0.8 1.5 9.0 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat FeoB_Cyto PF17910.1 AMD19915.1 - 1 9.9 3.8 1.4 9.5 0.8 2.6 2 0 0 2 2 2 0 FeoB cytosolic helical domain zf-C2H2_2 PF12756.7 AMD19916.1 - 4.3e-31 107.2 3.9 4.6e-28 97.5 1.2 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 AMD19916.1 - 0.12 12.5 2.0 14 5.9 0.4 2.6 2 0 0 2 2 2 0 Zinc ribbon domain CCG PF02754.16 AMD19916.1 - 0.24 11.6 1.5 8.5 6.7 0.0 3.0 3 0 0 3 3 3 0 Cysteine-rich domain zf-C2H2_4 PF13894.6 AMD19916.1 - 1.7 9.7 16.8 2.7 9.1 0.4 4.1 4 1 1 5 5 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AMD19916.1 - 2.8 8.4 13.5 0.37 11.1 0.8 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding RIBIOP_C PF04950.12 AMD19917.1 - 3.8e-100 335.1 0.0 6.3e-100 334.4 0.0 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 AMD19917.1 - 1.3e-21 76.4 0.0 3.9e-21 74.9 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Ribosomal_S14 PF00253.21 AMD19918.1 - 7.7e-17 60.8 2.0 8.5e-17 60.7 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Prim_Zn_Ribbon PF08273.12 AMD19918.1 - 0.086 13.1 2.0 3 8.2 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Peptidase_M16_M PF16187.5 AMD19919.1 - 1.7e-80 270.3 1.5 3.8e-80 269.2 1.5 1.6 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 AMD19919.1 - 3.2e-36 124.6 0.3 2.3e-35 121.8 0.2 2.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AMD19919.1 - 1.3e-25 90.4 1.4 1.2e-20 74.3 0.0 3.0 3 1 0 3 3 3 2 Peptidase M16 inactive domain UQ_con PF00179.26 AMD19922.1 - 1.1e-43 148.2 0.1 1.3e-43 148.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AMD19922.1 - 2.4e-05 24.1 0.0 2.7e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 AMD19922.1 - 0.42 10.9 1.9 0.65 10.3 1.9 1.7 1 1 0 1 1 1 0 RWD domain Pex19 PF04614.12 AMD19923.1 - 9.4e-57 192.6 13.2 1.6e-56 191.8 13.2 1.4 1 0 0 1 1 1 1 Pex19 protein family Cytochrom_B562 PF07361.11 AMD19923.1 - 0.0097 16.5 3.8 0.031 14.9 1.1 2.7 2 1 0 2 2 2 1 Cytochrome b562 Penicillinase_R PF03965.16 AMD19923.1 - 0.033 14.5 0.5 0.063 13.6 0.5 1.6 1 0 0 1 1 1 0 Penicillinase repressor XPC-binding PF09280.11 AMD19923.1 - 0.49 10.2 4.6 4.8 7.0 0.2 3.2 3 0 0 3 3 3 0 XPC-binding domain GET2 PF08690.10 AMD19923.1 - 1.5 8.4 18.0 0.34 10.6 7.3 2.3 1 1 1 2 2 2 0 GET complex subunit GET2 CFEM PF05730.11 AMD19924.1 - 4.2e-08 33.2 8.8 6.5e-08 32.6 8.8 1.3 1 0 0 1 1 1 1 CFEM domain Arrestin_N PF00339.29 AMD19925.1 - 3e-07 30.6 0.0 2.1e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain ATP-synt_10 PF05176.14 AMD19926.1 - 1e-75 254.3 0.0 1.2e-75 254.1 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein A2M_BRD PF07703.14 AMD19926.1 - 0.057 13.8 0.0 0.093 13.1 0.0 1.5 1 0 0 1 1 1 0 Alpha-2-macroglobulin bait region domain Iso_dh PF00180.20 AMD19927.1 - 4.8e-69 233.1 0.0 5.6e-69 232.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase REGB_T4 PF10715.9 AMD19927.1 - 0.0088 16.3 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 T4-page Endoribonuclease RegB DHFR_2 PF06442.11 AMD19927.1 - 0.049 13.5 0.0 6 6.8 0.0 2.4 2 0 0 2 2 2 0 R67 dihydrofolate reductase COX7C PF02935.16 AMD19928.1 - 2.1e-22 79.1 5.0 2.5e-22 78.9 5.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc COX6C PF02937.15 AMD19929.1 - 0.00057 20.0 0.0 0.0006 19.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Sec1 PF00995.23 AMD19930.1 - 1.2e-77 262.6 13.8 1.5e-77 262.2 13.8 1.1 1 0 0 1 1 1 1 Sec1 family AAA PF00004.29 AMD19931.1 - 7.9e-88 291.7 0.0 1.8e-42 144.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD19931.1 - 3e-17 62.1 2.5 4.2e-09 36.1 0.1 2.6 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AMD19931.1 - 4e-13 49.4 0.0 7.3e-06 25.8 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AMD19931.1 - 2.1e-11 44.5 0.8 3.8e-05 24.1 0.0 4.2 3 2 0 3 3 2 2 AAA ATPase domain AAA_5 PF07728.14 AMD19931.1 - 4.8e-11 42.8 0.4 0.00029 20.9 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 AMD19931.1 - 3e-09 37.2 0.0 0.00064 19.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AMD19931.1 - 3.8e-09 36.9 4.0 0.0006 20.1 0.2 4.3 2 2 1 3 3 3 2 AAA domain AAA_25 PF13481.6 AMD19931.1 - 4.2e-07 29.7 2.6 1.4 8.4 0.0 4.3 3 1 1 4 4 4 2 AAA domain AAA_33 PF13671.6 AMD19931.1 - 4.7e-07 30.1 0.0 0.0036 17.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 AMD19931.1 - 1e-06 28.8 0.0 3.4e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_14 PF13173.6 AMD19931.1 - 2.9e-06 27.3 0.0 0.019 15.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 AMD19931.1 - 4.8e-06 26.6 0.0 0.069 13.1 0.0 2.8 2 1 1 3 3 3 2 Rad17 P-loop domain RNA_helicase PF00910.22 AMD19931.1 - 8.7e-06 26.1 0.0 0.076 13.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.13 AMD19931.1 - 1e-05 24.9 0.0 0.037 13.2 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 AMD19931.1 - 4.5e-05 22.9 0.3 0.12 11.8 0.0 2.8 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 AMD19931.1 - 0.00014 21.8 0.0 0.055 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AMD19931.1 - 0.00015 22.0 0.0 0.75 10.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AMD19931.1 - 0.00042 20.3 0.5 0.095 12.6 0.0 3.8 4 0 0 4 4 4 1 NACHT domain AAA_7 PF12775.7 AMD19931.1 - 0.00084 18.9 0.0 0.38 10.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 AMD19931.1 - 0.00085 19.9 0.0 0.015 15.8 0.0 2.4 2 0 0 2 2 2 1 ABC transporter TsaE PF02367.17 AMD19931.1 - 0.0012 18.9 0.0 0.26 11.3 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 AMD19931.1 - 0.0015 18.3 0.0 0.68 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 AMD19931.1 - 0.0019 18.1 0.0 0.82 9.5 0.0 2.9 3 1 0 3 3 2 1 Bacterial dnaA protein AAA_3 PF07726.11 AMD19931.1 - 0.0024 17.7 0.0 2.4 8.0 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 AMD19931.1 - 0.0025 18.4 0.0 0.85 10.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 AMD19931.1 - 0.0026 17.2 0.1 5.6 6.3 0.0 3.6 4 1 1 5 5 3 0 Bacterial TniB protein IstB_IS21 PF01695.17 AMD19931.1 - 0.0032 17.2 0.0 2.7 7.7 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein DUF815 PF05673.13 AMD19931.1 - 0.0035 16.5 0.0 0.29 10.2 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 AMD19931.1 - 0.005 16.8 0.1 5.7 6.8 0.0 3.5 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 AMD19931.1 - 0.0089 16.2 0.0 0.26 11.4 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 AMD19931.1 - 0.012 15.9 0.3 0.39 11.1 0.1 2.7 3 1 0 3 3 2 0 AAA domain AFG1_ATPase PF03969.16 AMD19931.1 - 0.013 14.5 0.0 0.093 11.6 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase Sigma54_activat PF00158.26 AMD19931.1 - 0.015 15.0 0.0 6.1 6.5 0.0 3.6 4 0 0 4 4 3 0 Sigma-54 interaction domain AAA_30 PF13604.6 AMD19931.1 - 0.02 14.6 0.0 0.26 11.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 AMD19931.1 - 0.05 12.9 0.0 2.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Viral_helicase1 PF01443.18 AMD19931.1 - 0.052 13.3 0.0 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase SRPRB PF09439.10 AMD19931.1 - 0.071 12.5 0.0 0.43 10.0 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit ATPase PF06745.13 AMD19931.1 - 0.081 12.3 1.3 13 5.0 0.0 3.7 4 1 1 5 5 4 0 KaiC NTPase_1 PF03266.15 AMD19931.1 - 0.085 12.8 0.1 4.1 7.3 0.0 3.0 3 1 1 4 4 2 0 NTPase Vps4_C PF09336.10 AMD19931.1 - 0.12 12.4 0.0 4.9 7.2 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain DSHCT PF08148.12 AMD19933.1 - 1.2e-47 161.7 0.2 2.7e-47 160.5 0.2 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 AMD19933.1 - 1e-34 119.3 0.1 3.1e-34 117.7 0.1 1.8 2 0 0 2 2 2 1 Ski2 N-terminal region DEAD PF00270.29 AMD19933.1 - 8.4e-20 71.3 0.1 3.2e-19 69.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 AMD19933.1 - 5.4e-14 52.8 4.0 5.4e-14 52.8 4.0 1.8 2 0 0 2 2 2 1 rRNA-processing arch domain Helicase_C PF00271.31 AMD19933.1 - 1.9e-08 34.6 0.1 1.9e-07 31.4 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD19933.1 - 7e-06 26.2 0.3 2.3e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3516 PF12029.8 AMD19933.1 - 0.036 13.2 0.1 0.11 11.5 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3516) Bromodomain PF00439.25 AMD19934.1 - 4.5e-40 135.6 1.6 5.6e-19 68.0 0.3 2.6 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 AMD19934.1 - 9.7e-21 73.7 0.1 3.9e-20 71.8 0.1 2.2 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRCC36_C PF18110.1 AMD19934.1 - 0.16 12.2 0.8 0.49 10.6 0.8 1.8 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain Holin_BhlA PF10960.8 AMD19934.1 - 1.5 8.9 3.6 12 5.9 0.7 2.6 2 0 0 2 2 2 0 BhlA holin family Bap31 PF05529.12 AMD19935.1 - 2.4e-35 121.3 8.2 3e-35 121.0 8.2 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region ADIP PF11559.8 AMD19935.1 - 0.014 15.4 0.1 0.018 15.1 0.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding XLF PF09302.11 AMD19935.1 - 0.074 13.2 0.5 0.12 12.5 0.5 1.4 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Dus PF01207.17 AMD19936.1 - 3.5e-47 161.0 0.0 2.2e-45 155.1 0.0 2.2 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 AMD19936.1 - 3.2e-05 23.6 4.9 0.00029 20.6 0.1 2.9 2 0 0 2 2 2 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 AMD19936.1 - 0.01 15.8 0.2 0.01 15.8 0.2 2.6 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH PF00642.24 AMD19936.1 - 0.016 15.1 0.1 0.016 15.1 0.1 3.1 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 AMD19936.1 - 0.089 13.3 3.1 0.12 12.8 0.1 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 AMD19936.1 - 1.2 9.9 11.0 2.9 8.6 3.1 2.8 1 1 1 2 2 2 0 Torus domain zf-C2H2_jaz PF12171.8 AMD19937.1 - 0.00042 20.5 0.7 1.3 9.4 0.1 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding DUF3246 PF11596.8 AMD19937.1 - 0.0066 15.9 2.5 0.0066 15.9 2.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3246) zf-C2H2_aberr PF17017.5 AMD19937.1 - 0.014 15.6 0.5 0.014 15.6 0.5 2.8 3 0 0 3 3 3 0 Aberrant zinc-finger zf-C2H2 PF00096.26 AMD19937.1 - 0.029 14.8 1.4 0.029 14.8 1.4 4.2 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD19937.1 - 0.05 14.5 0.6 0.05 14.5 0.6 5.1 5 0 0 5 5 5 0 C2H2-type zinc finger PBP1_TM PF14812.6 AMD19937.1 - 0.28 11.6 6.4 0.85 10.0 6.4 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C2H2_6 PF13912.6 AMD19937.1 - 5.9 7.0 10.1 3.3 7.8 1.8 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Seipin PF06775.14 AMD19938.1 - 0.0031 17.6 0.2 0.08 13.0 0.0 2.3 2 0 0 2 2 2 2 Putative adipose-regulatory protein (Seipin) DUF1765 PF08578.10 AMD19939.1 - 1.5e-19 70.7 4.6 1.5e-19 70.7 4.6 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) BRE1 PF08647.11 AMD19940.1 - 5e-27 93.8 17.7 5e-27 93.8 17.7 7.0 5 2 1 6 6 6 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 AMD19940.1 - 2.9e-07 30.2 10.8 5.6e-07 29.3 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AMD19940.1 - 1.9e-06 27.6 9.7 3.5e-06 26.8 9.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 AMD19940.1 - 2e-06 27.5 11.9 4e-06 26.6 11.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD19940.1 - 1.9e-05 24.5 13.1 4e-05 23.4 13.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD19940.1 - 2.3e-05 24.3 12.8 5.1e-05 23.1 12.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AMD19940.1 - 0.00053 20.3 11.7 0.0011 19.2 11.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C2H2 PF00096.26 AMD19940.1 - 0.0046 17.3 0.1 0.0046 17.3 0.1 3.0 4 0 0 4 4 2 1 Zinc finger, C2H2 type ZapB PF06005.12 AMD19940.1 - 0.0082 16.6 1.4 0.0082 16.6 1.4 7.9 4 1 3 7 7 6 1 Cell division protein ZapB zf-RING_UBOX PF13445.6 AMD19940.1 - 0.013 15.5 10.0 0.029 14.4 10.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C2H2_jaz PF12171.8 AMD19940.1 - 0.024 14.9 1.6 0.63 10.4 0.0 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding SlyX PF04102.12 AMD19940.1 - 0.03 14.9 0.2 0.53 10.9 0.0 7.6 5 2 3 8 8 7 0 SlyX HTH_25 PF13413.6 AMD19940.1 - 0.094 12.6 0.6 11 5.9 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain zf-C2H2_4 PF13894.6 AMD19940.1 - 0.48 11.4 0.1 0.48 11.4 0.1 3.2 3 0 0 3 3 2 0 C2H2-type zinc finger zf-RING_4 PF14570.6 AMD19940.1 - 1 9.2 10.0 2.2 8.2 10.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 AMD19940.1 - 1.2 9.3 9.6 3.3 7.9 9.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Ecl1 PF12855.7 AMD19940.1 - 2.7 9.1 6.1 2.5 9.2 0.1 3.0 2 1 0 2 2 2 0 ECL1/2/3 zinc binding proteins DUF2935 PF11155.8 AMD19940.1 - 8.8 6.7 18.6 8.7 6.7 3.3 4.5 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) Dus PF01207.17 AMD19941.1 - 2.6e-77 260.0 0.0 3.2e-77 259.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 AMD19941.1 - 0.12 11.6 0.0 2.8 7.1 0.0 2.1 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase Ribosomal_L31e PF01198.19 AMD19942.1 - 1.6e-40 137.2 1.8 2e-40 136.9 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Rxt3 PF08642.10 AMD19943.1 - 2.6e-24 86.4 0.0 8.1e-24 84.8 0.0 1.8 1 1 0 1 1 1 1 Histone deacetylation protein Rxt3 DUF4050 PF13259.6 AMD19944.1 - 1.6e-10 41.6 0.6 1.6e-10 41.6 0.6 3.0 1 1 2 3 3 3 2 Protein of unknown function (DUF4050) GCN5L1 PF06320.13 AMD19945.1 - 0.00026 21.1 0.7 0.00044 20.4 0.7 1.5 1 1 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Vps39_1 PF10366.9 AMD19946.1 - 1.2e-29 102.8 3.4 2.6e-29 101.7 0.1 3.1 2 1 1 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 AMD19946.1 - 6.4e-16 58.8 0.2 2e-15 57.2 0.2 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 AMD19946.1 - 2.2e-07 30.8 10.0 0.0003 20.7 0.1 3.7 3 1 0 3 3 3 2 Region in Clathrin and VPS Utp21 PF04192.12 AMD19947.1 - 5.5e-76 255.1 0.8 8.5e-76 254.5 0.8 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 AMD19947.1 - 2.6e-16 59.7 13.0 7.4e-08 32.9 0.4 7.8 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD19947.1 - 3.3e-12 46.5 0.0 0.012 15.9 0.0 6.2 4 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain CPSF_A PF03178.15 AMD19947.1 - 3.8e-05 23.2 0.1 0.17 11.1 0.0 3.2 4 0 0 4 4 4 2 CPSF A subunit region eIF2A PF08662.11 AMD19947.1 - 0.0032 17.4 0.2 0.45 10.4 0.0 3.5 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_3 PF13570.6 AMD19947.1 - 0.11 13.0 1.2 48 4.6 0.1 3.9 3 0 0 3 3 3 0 PQQ-like domain His_Phos_2 PF00328.22 AMD19948.1 - 2.5e-136 455.0 0.1 3.6e-136 454.5 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 AMD19948.1 - 4.2e-37 126.2 0.1 1.1e-36 124.9 0.1 1.7 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 AMD19948.1 - 2.6e-08 33.7 0.0 5.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain SYCE1 PF15233.6 AMD19948.1 - 0.025 14.6 2.9 0.078 13.0 2.9 1.8 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 Pribosyl_synth PF14572.6 AMD19949.1 - 1.2e-40 139.5 1.2 2.4e-32 112.4 0.2 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AMD19949.1 - 3.8e-39 133.2 0.0 1e-38 131.9 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AMD19949.1 - 1.2e-08 34.7 0.1 0.0053 16.3 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl transferase domain SRR1 PF07985.12 AMD19950.1 - 5.3e-21 74.4 0.1 1.1e-20 73.4 0.1 1.6 1 0 0 1 1 1 1 SRR1 DUF1729 PF08354.10 AMD19951.1 - 5.5e-160 532.1 0.0 8e-160 531.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 AMD19951.1 - 6.3e-98 328.2 0.0 2.3e-97 326.3 0.0 2.0 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 AMD19951.1 - 9.4e-41 139.0 0.0 1.9e-40 138.1 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain MaoC_dehydratas PF01575.19 AMD19951.1 - 9.9e-36 122.0 0.0 1.7e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 AMD19951.1 - 1.5e-34 119.8 0.0 4.2e-34 118.3 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 AMD19951.1 - 9.6e-30 103.2 0.0 2.2e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 AMD19951.1 - 2.3e-13 50.4 0.0 6.7e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.15 AMD19951.1 - 0.0025 17.3 0.5 0.048 13.0 0.1 2.9 2 1 0 2 2 2 1 Nitronate monooxygenase Voldacs PF03517.13 AMD19952.1 - 3e-17 63.0 0.1 4.6e-17 62.4 0.1 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Orn_Arg_deC_N PF02784.16 AMD19953.1 - 1.8e-77 260.1 0.0 2.5e-77 259.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 AMD19953.1 - 5.1e-19 68.3 0.0 7.6e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Mo25 PF08569.11 AMD19954.1 - 2.8e-112 375.3 6.8 3.2e-112 375.1 6.8 1.0 1 0 0 1 1 1 1 Mo25-like Vps36_ESCRT-II PF11605.8 AMD19955.1 - 2.7e-31 107.6 0.4 7.8e-31 106.1 0.4 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 EAP30 PF04157.16 AMD19955.1 - 8.7e-19 67.7 0.6 2.5e-17 63.0 0.6 2.2 1 1 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 AMD19955.1 - 5.4e-15 54.5 2.8 5.4e-15 54.5 2.8 2.6 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 AMD19955.1 - 3e-05 24.0 3.2 0.0019 18.2 0.1 3.0 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 AMD19955.1 - 0.0073 15.6 9.1 0.21 10.9 1.7 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others PH_TFIIH PF08567.11 AMD19955.1 - 0.017 15.5 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain bPH_3 PF14470.6 AMD19955.1 - 0.047 14.1 0.1 0.14 12.6 0.1 1.8 1 0 0 1 1 1 0 Bacterial PH domain Ima1_N PF09779.9 AMD19955.1 - 0.36 11.7 2.7 0.84 10.5 2.7 1.6 1 0 0 1 1 1 0 Ima1 N-terminal domain CTU2 PF10288.9 AMD19955.1 - 0.42 10.9 3.1 1.8 8.8 1.3 2.5 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 DZR PF12773.7 AMD19955.1 - 0.46 10.5 5.8 0.33 11.0 0.9 2.2 1 1 1 2 2 2 0 Double zinc ribbon RecR PF02132.15 AMD19955.1 - 2.4 7.8 6.9 27 4.4 1.9 3.5 3 0 0 3 3 3 0 RecR protein ABC_membrane_2 PF06472.15 AMD19956.1 - 1.2e-61 208.5 6.2 1.3e-40 139.5 0.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.27 AMD19956.1 - 1.1e-17 64.8 0.0 2.6e-17 63.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AMD19956.1 - 4.3e-05 23.5 0.3 0.00026 20.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AMD19956.1 - 0.0051 17.3 5.4 0.088 13.3 3.8 3.2 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 AMD19956.1 - 0.007 16.3 0.2 0.023 14.6 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_29 PF13555.6 AMD19956.1 - 0.03 14.1 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 AMD19956.1 - 0.04 13.4 0.1 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AMD19956.1 - 0.084 12.6 0.9 0.31 10.7 0.0 2.0 1 1 0 2 2 2 0 AAA ATPase domain Phage_holin_2_1 PF04971.12 AMD19956.1 - 0.1 12.6 0.6 9.1 6.4 0.1 2.5 2 0 0 2 2 2 0 Bacteriophage P21 holin S AAA_5 PF07728.14 AMD19956.1 - 0.11 12.5 0.7 1.7 8.7 0.1 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AMD19956.1 - 0.13 11.7 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SUR7 PF06687.12 AMD19957.1 - 1.9e-17 63.6 7.5 2.2e-16 60.2 7.5 2.1 1 1 0 1 1 1 1 SUR7/PalI family Mtr2 PF10429.9 AMD19958.1 - 2.5e-65 219.4 0.2 3e-65 219.2 0.2 1.0 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 GATA PF00320.27 AMD19959.1 - 3.5e-07 29.7 11.3 3.5e-07 29.7 11.3 3.3 4 0 0 4 4 4 1 GATA zinc finger zf-CCHC PF00098.23 AMD19960.1 - 1.4e-06 28.1 14.9 0.00014 21.8 2.0 5.3 5 1 0 5 5 5 3 Zinc knuckle zf-C2H2_10 PF16588.5 AMD19960.1 - 0.026 14.2 7.4 0.026 14.2 7.4 4.7 4 1 1 5 5 5 0 C2H2 zinc-finger tRNA-synt_2b PF00587.25 AMD19961.1 - 2.1e-35 122.3 0.0 4.1e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AMD19961.1 - 1.1e-19 70.4 0.5 2.8e-19 69.1 0.5 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 AMD19961.1 - 2.7e-13 49.8 0.0 5.8e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 AMD19961.1 - 5.2e-12 45.6 0.0 5e-11 42.5 0.0 2.2 2 0 0 2 2 2 1 TGS domain DUF1689 PF07954.11 AMD19962.1 - 2.5e-47 160.9 1.3 3.9e-47 160.3 0.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1689) Coatomer_E PF04733.14 AMD19963.1 - 2.5e-12 46.8 3.4 1.2e-11 44.6 3.4 1.9 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 AMD19963.1 - 0.00033 21.1 5.0 0.019 15.4 0.4 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat GET2 PF08690.10 AMD19964.1 - 4.9e-73 246.5 0.0 5.9e-73 246.2 0.0 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 DHO_dh PF01180.21 AMD19965.1 - 4e-97 325.0 0.1 4.9e-97 324.7 0.1 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 AMD19965.1 - 1.1e-05 24.7 0.0 0.019 14.0 0.3 2.7 2 1 0 2 2 2 2 FMN-dependent dehydrogenase BING4CT PF08149.11 AMD19966.1 - 2.6e-38 129.7 0.0 7e-35 118.7 0.0 3.5 3 0 0 3 3 3 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 AMD19966.1 - 6.2e-07 29.6 0.0 0.69 10.3 0.0 4.7 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD19966.1 - 5.1e-06 27.1 0.3 0.0098 16.7 0.0 4.7 5 1 0 5 5 5 1 WD domain, G-beta repeat PQQ_2 PF13360.6 AMD19966.1 - 0.01 15.5 0.0 0.035 13.7 0.0 1.8 1 1 0 1 1 1 0 PQQ-like domain RPN2_C PF18004.1 AMD19967.1 - 9.7e-50 168.6 5.7 1.5e-49 168.0 5.7 1.3 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 AMD19967.1 - 9.2e-38 126.8 19.9 1.7e-06 28.2 0.3 8.9 8 0 0 8 8 8 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 AMD19967.1 - 3.1e-19 69.1 0.3 2.1e-14 53.7 0.0 4.3 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 AMD19967.1 - 5.7e-09 35.5 0.2 1.6 9.2 0.0 5.7 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 AMD19967.1 - 0.003 18.0 6.3 0.24 12.0 0.0 4.7 4 1 1 5 5 5 2 HEAT-like repeat RICTOR_V PF14668.6 AMD19967.1 - 0.13 12.5 0.0 0.77 10.0 0.0 2.5 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 Cnd1 PF12717.7 AMD19967.1 - 0.25 11.4 4.6 20 5.2 0.0 3.9 2 2 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 2-Hacid_dh_C PF02826.19 AMD19968.1 - 1.3e-55 187.5 0.0 2.3e-55 186.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AMD19968.1 - 3.7e-39 133.5 0.1 4.9e-39 133.1 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 AMD19968.1 - 6.4e-05 23.2 0.1 0.00015 21.9 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 AMD19968.1 - 0.00011 22.4 0.1 0.00021 21.4 0.1 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.25 AMD19968.1 - 0.0065 16.2 0.0 0.02 14.6 0.0 1.9 1 0 0 1 1 1 1 ACT domain Acetyltransf_1 PF00583.25 AMD19968.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family EF-hand_1 PF00036.32 AMD19969.1 - 2.7e-23 79.7 12.6 1e-05 24.7 0.4 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AMD19969.1 - 2.9e-21 75.7 8.9 3.8e-13 49.7 2.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AMD19969.1 - 1.9e-19 67.9 7.7 0.00023 20.9 0.4 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 AMD19969.1 - 5.8e-15 54.0 14.3 0.0021 17.4 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 AMD19969.1 - 5.4e-12 45.4 15.4 0.0006 19.6 1.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 AMD19969.1 - 4.6e-07 29.7 7.3 0.0096 15.9 0.2 3.7 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 AMD19969.1 - 3.2e-06 27.4 0.1 0.12 12.8 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 AMD19969.1 - 0.013 15.9 0.1 8.8 6.7 0.0 2.6 2 1 1 3 3 3 0 EF-hand domain CDC73_C PF05179.14 AMD19970.1 - 5.8e-51 172.3 2.0 1.1e-50 171.4 2.0 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal MinE PF03776.14 AMD19970.1 - 0.031 14.3 0.0 7 6.7 0.0 3.2 2 1 1 3 3 3 0 Septum formation topological specificity factor MinE CDC73_N PF16050.5 AMD19970.1 - 0.042 13.2 0.1 0.21 10.9 0.1 2.0 1 1 1 2 2 2 0 Paf1 complex subunit CDC73 N-terminal Helicase_C PF00271.31 AMD19971.1 - 5.8e-16 58.8 2.2 3e-14 53.3 0.3 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AMD19971.1 - 6.6e-15 55.2 0.0 1.8e-14 53.9 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 AMD19971.1 - 1.1e-11 44.8 0.5 2.9e-11 43.5 0.5 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RWD PF05773.22 AMD19971.1 - 7.5e-10 39.1 0.6 2.5e-09 37.4 0.6 2.0 1 0 0 1 1 1 1 RWD domain HA2 PF04408.23 AMD19971.1 - 3.5e-06 27.3 0.6 1.2e-05 25.6 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) AAA_19 PF13245.6 AMD19971.1 - 9.9e-05 22.7 0.1 0.00021 21.6 0.1 1.6 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 AMD19971.1 - 0.00054 19.5 0.2 0.0021 17.5 0.0 2.0 3 0 0 3 3 3 1 PhoH-like protein AAA_29 PF13555.6 AMD19971.1 - 0.00093 18.9 0.0 0.0021 17.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SSE PF00437.20 AMD19971.1 - 0.0028 16.8 0.0 0.0055 15.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 AMD19971.1 - 0.0037 17.0 0.0 0.0076 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 AMD19971.1 - 0.0054 16.1 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 KaiC UBA PF00627.31 AMD19971.1 - 0.019 14.9 0.8 0.83 9.6 0.1 2.5 2 0 0 2 2 2 0 UBA/TS-N domain DUF494 PF04361.13 AMD19971.1 - 0.02 14.8 0.0 0.061 13.2 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF494) AAA_22 PF13401.6 AMD19971.1 - 0.025 14.9 0.3 0.096 13.0 0.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AMD19971.1 - 0.03 13.9 0.0 0.064 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Zot PF05707.12 AMD19971.1 - 0.045 13.4 0.1 0.17 11.5 0.1 2.0 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_23 PF13476.6 AMD19971.1 - 0.17 12.4 0.1 0.17 12.4 0.1 3.6 4 1 0 4 4 3 0 AAA domain Y_phosphatase PF00102.27 AMD19972.1 - 1.3e-51 175.4 0.0 2.4e-51 174.6 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 AMD19972.1 - 1.1e-07 32.3 0.0 5.4e-07 30.1 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 AMD19972.1 - 0.005 16.7 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AMD19972.1 - 0.039 13.9 0.1 0.093 12.7 0.1 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family Yos1 PF08571.10 AMD19973.1 - 1.1e-32 112.1 1.5 1.2e-32 112.0 1.5 1.0 1 0 0 1 1 1 1 Yos1-like Ribosomal_S24e PF01282.19 AMD19974.1 - 2e-34 117.4 0.1 3.3e-34 116.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e Aldedh PF00171.22 AMD19975.1 - 5.3e-180 598.9 0.0 6e-180 598.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Tctex-1 PF03645.13 AMD19976.1 - 1.9e-06 28.0 0.0 2.5e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 Tctex-1 family Sec6 PF06046.13 AMD19977.1 - 4.3e-159 530.6 16.4 5.7e-159 530.2 16.4 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 DUF4477 PF14780.6 AMD19977.1 - 0.15 11.7 1.3 0.38 10.3 1.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) TBCC_N PF16752.5 AMD19977.1 - 0.42 11.1 6.2 0.13 12.7 2.0 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Laminin_II PF06009.12 AMD19977.1 - 1.9 8.5 10.7 0.033 14.2 1.4 2.9 4 0 0 4 4 4 0 Laminin Domain II LCCL PF03815.19 AMD19978.1 - 1.6e-12 47.4 0.3 2.7e-12 46.6 0.3 1.4 1 0 0 1 1 1 1 LCCL domain DUF1069 PF06370.11 AMD19978.1 - 0.007 16.0 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1069) DUF3262 PF11660.8 AMD19978.1 - 0.93 9.9 4.5 7.1 7.1 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) Ribonuc_red_lgC PF02867.15 AMD19979.1 - 4.1e-186 619.6 0.0 5.4e-186 619.2 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AMD19979.1 - 1.1e-23 83.0 0.1 3.9e-23 81.3 0.1 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AMD19979.1 - 1.5e-17 63.9 0.4 7.2e-16 58.5 0.0 3.3 4 0 0 4 4 4 1 ATP cone domain Fis1_TPR_C PF14853.6 AMD19980.1 - 1.4e-21 76.3 0.7 2.3e-21 75.6 0.7 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 AMD19980.1 - 1.6e-16 59.6 0.1 3.3e-16 58.7 0.1 1.5 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat DUF4287 PF14117.6 AMD19980.1 - 0.051 13.7 0.0 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4287) OSCP PF00213.18 AMD19980.1 - 0.075 13.2 0.3 5.3 7.1 0.2 2.2 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit Methyltransf_31 PF13847.6 AMD19981.1 - 8.7e-29 100.3 0.0 1.4e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD19981.1 - 1e-10 42.1 0.0 1.9e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD19981.1 - 1.3e-09 38.7 0.0 2.2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD19981.1 - 4.8e-09 36.7 0.0 9.2e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 AMD19981.1 - 2.5e-08 34.1 0.0 3.5e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD19981.1 - 6e-06 26.2 0.0 1.3e-05 25.1 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 AMD19981.1 - 6.5e-06 25.8 0.0 1.4e-05 24.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain PCMT PF01135.19 AMD19981.1 - 2.7e-05 24.0 0.0 4.6e-05 23.3 0.0 1.3 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 AMD19981.1 - 3.6e-05 23.2 0.1 4.7e-05 22.8 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TPMT PF05724.11 AMD19981.1 - 6.6e-05 22.7 0.0 0.00014 21.7 0.0 1.5 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_18 PF12847.7 AMD19981.1 - 7.3e-05 22.7 0.0 0.00031 20.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 AMD19981.1 - 0.00022 20.7 0.0 0.00071 19.1 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase AdoMet_MTase PF07757.13 AMD19981.1 - 0.0019 18.5 0.0 0.003 17.9 0.0 1.5 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase DOT1 PF08123.13 AMD19981.1 - 0.0026 17.3 0.0 0.0044 16.6 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 MetW PF07021.12 AMD19981.1 - 0.009 15.6 0.0 0.015 14.9 0.0 1.6 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 AMD19981.1 - 0.01 15.2 0.0 0.015 14.6 0.0 1.3 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family TehB PF03848.14 AMD19981.1 - 0.015 14.7 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB PrmA PF06325.13 AMD19981.1 - 0.029 13.7 0.0 0.048 13.1 0.0 1.5 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ran_BP1 PF00638.18 AMD19982.1 - 1.6e-31 109.1 0.0 2.8e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain P16-Arc PF04699.14 AMD19983.1 - 9.1e-43 146.3 0.0 1e-42 146.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Sigma70_r4 PF04545.16 AMD19983.1 - 0.068 12.7 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 NAT PF04768.13 AMD19984.1 - 1e-41 142.4 0.1 2.8e-41 141.0 0.0 1.8 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 AMD19984.1 - 3e-28 98.7 0.0 1.5e-27 96.4 0.0 2.3 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 AMD19984.1 - 3.8e-26 92.2 0.0 1.1e-25 90.7 0.0 1.7 2 0 0 2 2 2 1 Amino acid kinase family Semialdhyde_dhC PF02774.18 AMD19984.1 - 2.5e-07 30.9 0.0 1.6e-06 28.3 0.0 2.4 3 0 0 3 3 3 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 AMD19984.1 - 0.038 14.1 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus U1snRNP70_N PF12220.8 AMD19985.1 - 1e-20 74.2 4.4 1e-20 74.2 4.4 1.9 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 AMD19985.1 - 2.7e-15 55.9 0.0 6e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD19985.1 - 0.00026 21.1 0.0 0.00051 20.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif zf-RING_4 PF14570.6 AMD19986.1 - 2.5e-20 72.0 13.2 4.8e-20 71.1 13.2 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 AMD19986.1 - 9.5e-09 35.0 0.1 2.4e-08 33.7 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 AMD19986.1 - 4.2e-07 29.7 8.2 4.2e-07 29.7 8.2 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 AMD19986.1 - 3.5e-06 27.0 3.9 3.5e-06 27.0 3.9 2.0 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) SET_assoc PF11767.8 AMD19986.1 - 0.00025 20.6 0.2 0.0058 16.2 0.0 2.6 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated zf-RING_2 PF13639.6 AMD19986.1 - 0.00049 20.4 9.9 0.0012 19.2 9.9 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 AMD19986.1 - 0.001 18.9 7.7 0.04 13.8 8.5 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 Rtf2 PF04641.12 AMD19986.1 - 0.0011 18.4 3.2 0.0011 18.4 3.2 3.0 3 0 0 3 3 3 1 Rtf2 RING-finger zf-C3HC4 PF00097.25 AMD19986.1 - 0.0031 17.3 11.3 0.0071 16.2 11.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD19986.1 - 0.27 11.3 9.5 0.79 9.8 9.5 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 AMD19986.1 - 0.52 10.3 10.2 1.2 9.1 10.2 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AMD19986.1 - 0.69 9.8 10.3 1.6 8.7 10.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AMD19986.1 - 3.9 7.7 10.1 20 5.4 10.1 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING RGI1 PF10843.8 AMD19987.1 - 1.7e-34 119.2 11.2 3.6e-34 118.1 11.2 1.5 1 1 0 1 1 1 1 Respiratory growth induced protein 1 ICL PF00463.21 AMD19988.1 - 3.9e-261 867.1 0.1 4.4e-261 866.9 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 AMD19988.1 - 5.9e-10 39.0 0.0 1.1e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Vhr1 PF04001.13 AMD19989.1 - 2.6e-45 152.6 1.8 5.9e-45 151.5 1.8 1.6 1 0 0 1 1 1 1 Transcription factor Vhr1 Tho1_MOS11_C PF18592.1 AMD19991.1 - 4.4e-23 80.8 1.2 6.9e-23 80.2 1.2 1.3 1 0 0 1 1 1 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 AMD19991.1 - 2e-13 49.7 0.6 4.8e-13 48.5 0.2 1.9 2 0 0 2 2 2 1 SAP domain HAD_2 PF13419.6 AMD19992.1 - 1.6e-13 51.2 0.0 2.2e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AMD19992.1 - 5.1e-10 40.0 0.0 1.2e-07 32.2 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AMD19992.1 - 0.0064 16.5 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like ketoacyl-synt PF00109.26 AMD19993.1 - 4.1e-51 174.0 0.0 6.8e-51 173.3 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 AMD19993.1 - 4.8e-29 100.8 0.3 7.5e-29 100.1 0.3 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Steroid_dh PF02544.16 AMD19994.1 - 2.4e-14 53.6 3.5 2.4e-14 53.6 3.5 2.0 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Transp_cyt_pur PF02133.15 AMD19995.1 - 9.7e-48 163.0 44.0 1.2e-47 162.8 44.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Cyclin PF08613.11 AMD19996.1 - 4.1e-46 157.3 0.1 4.1e-46 157.3 0.1 1.6 2 0 0 2 2 2 1 Cyclin PET117 PF15786.5 AMD19997.1 - 2.6e-26 91.6 9.0 1.4e-25 89.4 9.0 1.8 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial IgaA PF07095.11 AMD19997.1 - 0.1 10.6 0.2 0.11 10.5 0.2 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA Ribonuc_L-PSP PF01042.21 AMD19998.1 - 3.1e-43 146.7 0.2 3.5e-43 146.5 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP GIT1_C PF12205.8 AMD19998.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Ribosomal_L34e PF01199.18 AMD19999.1 - 3.7e-42 142.5 3.6 3.7e-42 142.5 3.6 1.8 2 0 0 2 2 2 1 Ribosomal protein L34e FhuF_C PF11575.8 AMD19999.1 - 0.33 10.9 3.1 11 6.1 0.2 2.4 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain PhoLip_ATPase_C PF16212.5 AMD20000.1 - 3.2e-53 181.0 13.7 3.2e-53 181.0 13.7 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AMD20000.1 - 5.2e-18 64.5 4.2 1.5e-17 63.1 4.2 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 AMD20000.1 - 1.3e-11 44.4 0.0 1.3e-11 44.4 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 AMD20000.1 - 5.3e-11 42.4 0.0 1.2e-07 31.8 0.0 2.6 2 0 0 2 2 2 2 Cation transport ATPase (P-type) Hydrolase PF00702.26 AMD20000.1 - 4.9e-10 40.1 0.4 2.4e-06 28.0 0.4 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AMD20000.1 - 0.005 16.6 0.0 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Prot_ATP_ID_OB PF16450.5 AMD20000.1 - 0.082 12.9 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain EXS PF03124.14 AMD20001.1 - 5.5e-83 279.0 30.1 8e-83 278.5 30.1 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 AMD20001.1 - 2.1e-36 126.7 0.9 2e-22 80.7 0.0 2.3 1 1 1 2 2 2 2 SPX domain DUF443 PF04276.12 AMD20001.1 - 5.9 6.7 13.0 0.049 13.4 4.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF443) HisG PF01634.18 AMD20002.1 - 4.4e-52 176.3 0.1 6.2e-52 175.8 0.1 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 AMD20002.1 - 1.2e-24 86.2 0.0 2.5e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 AMD20002.1 - 0.0025 17.8 0.1 0.0033 17.4 0.1 1.2 1 0 0 1 1 1 1 NMT1/THI5 like WD40 PF00400.32 AMD20003.1 - 5.4e-38 128.3 29.6 2.3e-06 28.2 0.7 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 AMD20003.1 - 2.2e-13 49.9 0.8 4.8e-13 48.8 0.8 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AMD20003.1 - 2.4e-08 33.7 0.2 7.4e-08 32.1 0.1 1.9 2 0 0 2 2 2 1 F-box domain Nup160 PF11715.8 AMD20003.1 - 3.7e-08 32.5 13.2 0.018 13.7 0.1 5.7 2 2 4 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 AMD20003.1 - 2.2e-07 31.1 2.4 3.9 7.8 0.0 5.8 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 AMD20003.1 - 0.0004 20.4 0.0 0.56 10.3 0.0 4.0 2 1 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region F-box_4 PF15966.5 AMD20003.1 - 0.0069 16.3 0.1 0.03 14.2 0.0 2.2 2 0 0 2 2 2 1 F-box CBM_21 PF03370.13 AMD20004.1 - 6.6e-22 77.8 0.0 1.7e-21 76.5 0.0 1.7 1 1 1 2 2 2 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 AMD20004.1 - 3.5e-11 43.5 0.0 1.1e-10 42.0 0.0 1.8 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) nec1 PF10379.9 AMD20004.1 - 0.056 12.9 0.1 0.09 12.3 0.1 1.3 1 0 0 1 1 1 0 Virulence protein nec1 ArfGap PF01412.18 AMD20005.1 - 5.3e-35 120.0 0.5 1.6e-34 118.4 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf LRRFIP PF09738.9 AMD20005.1 - 0.29 10.6 2.8 0.45 9.9 2.8 1.2 1 0 0 1 1 1 0 LRRFIP family Cyt-b5 PF00173.28 AMD20006.1 - 2.8e-20 72.2 0.0 6.1e-20 71.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AA_kinase PF00696.28 AMD20007.1 - 2.3e-40 138.7 0.3 4.9e-40 137.6 0.1 1.7 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 AMD20007.1 - 8.6e-10 38.2 0.3 9.4e-05 22.1 0.2 2.6 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 AMD20007.1 - 5.2e-09 35.8 2.5 1.2e-06 28.1 0.5 2.7 2 0 0 2 2 2 2 ACT domain FAD_binding_6 PF00970.24 AMD20008.1 - 4.6e-30 103.9 0.0 7.2e-30 103.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 AMD20008.1 - 5.2e-29 101.1 0.0 9.1e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 AMD20008.1 - 2.4e-06 27.8 0.0 0.0012 19.0 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain PHD PF00628.29 AMD20009.1 - 2.8e-07 30.3 5.1 5.4e-07 29.4 5.1 1.5 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.6 AMD20009.1 - 9.7e-07 28.7 0.0 9.1e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain JHD PF17811.1 AMD20009.1 - 0.002 18.6 0.8 0.0061 17.1 0.1 2.1 3 0 0 3 3 2 1 Jumonji helical domain JmjC PF02373.22 AMD20009.1 - 0.0052 17.2 0.0 0.052 14.0 0.0 2.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-CW PF07496.15 AMD20009.1 - 0.016 15.2 2.8 0.13 12.3 0.9 2.6 2 0 0 2 2 2 0 CW-type Zinc Finger Cupin_2 PF07883.11 AMD20009.1 - 0.023 14.4 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 AMD20009.1 - 0.034 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_4 PF08007.12 AMD20009.1 - 0.068 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Cupin superfamily protein zf-HC5HC2H_2 PF13832.6 AMD20009.1 - 0.075 13.2 3.4 0.13 12.4 3.4 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain C1_1 PF00130.22 AMD20009.1 - 0.19 11.6 3.3 0.39 10.6 3.3 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H PF13771.6 AMD20009.1 - 0.21 11.9 5.5 0.085 13.1 2.9 1.7 2 0 0 2 2 2 0 PHD-like zinc-binding domain Peptidase_C48 PF02902.19 AMD20010.1 - 1.9e-34 119.4 2.5 1.9e-34 119.4 2.5 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain RINGv PF12906.7 AMD20011.1 - 8.2e-15 54.7 7.0 1.4e-14 53.9 7.0 1.4 1 0 0 1 1 1 1 RING-variant domain Sugar_tr PF00083.24 AMD20012.1 - 5.1e-94 315.7 27.5 8.8e-72 242.4 16.2 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 AMD20012.1 - 7.5e-24 84.3 29.8 9.5e-23 80.7 22.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 AMD20012.1 - 0.012 16.1 1.0 0.031 14.8 1.0 1.6 1 0 0 1 1 1 0 Phage holin family 2 DUF2373 PF10180.9 AMD20013.1 - 4.8e-23 80.8 0.0 7.3e-23 80.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) HAD PF12710.7 AMD20014.1 - 0.073 13.5 0.1 0.15 12.4 0.1 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DNA_pol_lambd_f PF10391.9 AMD20015.1 - 6.2e-12 45.1 1.5 4.3e-11 42.5 0.9 2.5 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 AMD20015.1 - 6.6e-12 45.6 0.0 3.6e-11 43.3 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 AMD20015.1 - 4.7e-11 42.9 0.0 9.3e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_B_thumb PF14791.6 AMD20015.1 - 3.2e-10 40.0 0.0 7.8e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb BRCT_2 PF16589.5 AMD20015.1 - 0.00096 19.5 0.0 0.0024 18.3 0.0 1.7 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PGK PF00162.19 AMD20016.1 - 5.9e-150 499.4 0.5 6.7e-150 499.2 0.5 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase TTKRSYEDQ PF10212.9 AMD20016.1 - 0.17 10.9 0.0 0.24 10.4 0.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein TIP120 PF08623.10 AMD20017.1 - 0.11 12.2 0.0 0.32 10.7 0.0 1.8 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) TauD PF02668.16 AMD20018.1 - 4e-35 121.9 0.2 5.8e-35 121.4 0.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 AMD20018.1 - 5.2e-07 30.2 0.5 2.2e-06 28.2 0.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 AMD20018.1 - 0.00076 18.7 0.1 0.17 11.0 0.0 2.1 2 0 0 2 2 2 2 CsiD GTP_EFTU PF00009.27 AMD20019.1 - 2.2e-30 105.7 5.4 8.9e-29 100.4 5.4 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 AMD20019.1 - 7.2e-27 93.6 2.2 1.7e-26 92.4 2.2 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 AMD20019.1 - 6.9e-09 35.8 1.6 9.3e-08 32.1 0.3 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD20019.1 - 0.00094 19.1 2.1 0.019 14.9 0.9 2.6 1 1 1 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 AMD20019.1 - 0.011 15.4 4.5 0.022 14.5 1.9 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 AMD20019.1 - 0.016 15.3 0.1 0.46 10.5 0.1 2.7 1 1 0 1 1 1 0 Dynamin family Roc PF08477.13 AMD20019.1 - 0.023 14.9 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 AMD20019.1 - 0.054 12.9 0.1 0.1 12.0 0.1 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PDCD2_C PF04194.13 AMD20020.1 - 3.3e-42 144.5 0.0 4.1e-39 134.4 0.0 2.5 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain DUF1462 PF07315.11 AMD20020.1 - 0.13 12.6 0.0 0.35 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) WD40 PF00400.32 AMD20021.1 - 6.9e-41 137.5 17.6 3.7e-10 40.2 0.1 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20021.1 - 1.9e-12 47.3 3.6 0.01 16.2 0.1 5.1 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD20021.1 - 2.1e-10 39.9 10.7 0.0024 16.6 0.2 4.9 1 1 3 4 4 4 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AMD20021.1 - 1.5e-07 30.7 1.2 0.089 11.7 0.0 4.6 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 AMD20021.1 - 2.1e-05 23.5 1.3 0.0035 16.2 0.1 3.5 1 1 2 4 4 4 2 Nup133 N terminal like Frtz PF11768.8 AMD20021.1 - 5.1e-05 21.8 0.0 0.00025 19.5 0.0 1.9 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 AMD20021.1 - 0.00083 19.1 2.3 3.2 7.4 0.1 4.5 2 1 2 4 4 4 2 TUP1-like enhancer of split PALB2_WD40 PF16756.5 AMD20021.1 - 0.0054 15.7 3.2 0.008 15.1 0.1 2.6 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 AMD20021.1 - 0.047 13.0 0.0 1.1 8.5 0.0 2.3 1 1 2 3 3 3 0 WD40-like domain RFX_DNA_binding PF02257.15 AMD20022.1 - 2e-29 102.0 0.0 7.1e-29 100.3 0.0 2.0 2 0 0 2 2 2 1 RFX DNA-binding domain Pyrophosphatase PF00719.19 AMD20022.1 - 0.00042 20.2 4.2 0.0033 17.2 0.1 2.9 2 1 1 3 3 3 1 Inorganic pyrophosphatase Pox_D5 PF03288.16 AMD20022.1 - 0.0007 20.0 0.1 0.029 14.8 0.0 2.6 2 0 0 2 2 2 1 Poxvirus D5 protein-like Ribosomal_L30 PF00327.20 AMD20023.1 - 2.7e-09 36.8 0.7 6.6e-09 35.5 0.7 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Iso_dh PF00180.20 AMD20024.1 - 1.1e-123 412.8 0.0 1.3e-123 412.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aminotran_5 PF00266.19 AMD20025.1 - 1.8e-98 329.9 0.0 2.2e-98 329.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 AMD20025.1 - 1.9e-09 37.3 0.1 4.5e-09 36.1 0.1 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 AMD20025.1 - 6.5e-08 32.2 0.0 7.8e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 AMD20025.1 - 7.5e-05 21.6 0.1 0.00011 21.1 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 AMD20025.1 - 0.0012 17.5 0.2 0.0017 17.0 0.2 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Styelin PF17562.2 AMD20025.1 - 0.0093 16.3 0.5 2.8 8.3 0.1 2.6 2 0 0 2 2 2 2 Styelin 4_1_CTD PF05902.13 AMD20025.1 - 0.42 10.7 2.6 0.45 10.6 0.7 1.9 2 0 0 2 2 2 0 4.1 protein C-terminal domain (CTD) Mito_carr PF00153.27 AMD20026.1 - 9.3e-51 169.7 4.2 3.7e-18 65.2 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein COG5 PF10392.9 AMD20026.1 - 0.023 14.9 0.4 0.035 14.3 0.4 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Dcc1 PF09724.9 AMD20027.1 - 8.4e-71 239.0 0.0 9.8e-71 238.8 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 DUF3507 PF12015.8 AMD20028.1 - 2e-58 197.1 0.0 5e-58 195.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) RRM_1 PF00076.22 AMD20029.1 - 1.5e-51 172.1 0.0 2.9e-18 65.4 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 AMD20029.1 - 3.6e-05 23.6 0.0 0.042 13.6 0.0 2.9 3 0 0 3 3 3 2 Rrp7 RRM-like N-terminal domain RRM_9 PF18444.1 AMD20029.1 - 0.0045 16.8 0.0 0.3 11.0 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif DUF1325 PF07039.11 AMD20030.1 - 3.2e-38 130.8 0.0 6.2e-38 129.9 0.0 1.5 2 0 0 2 2 2 1 SGF29 tudor-like domain Agenet PF05641.12 AMD20030.1 - 1.3e-05 25.6 0.0 0.014 15.9 0.0 2.3 2 0 0 2 2 2 2 Agenet domain Tudor_3 PF18115.1 AMD20030.1 - 5.1e-05 23.0 0.0 0.00013 21.8 0.0 1.7 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 AMD20030.1 - 0.014 15.4 0.0 0.034 14.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) MHC_II_alpha PF00993.20 AMD20030.1 - 0.058 13.1 0.6 1.1 9.0 0.2 2.2 2 0 0 2 2 2 0 Class II histocompatibility antigen, alpha domain Epimerase_2 PF02350.19 AMD20030.1 - 0.089 11.6 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Ribosomal_L27_C PF18471.1 AMD20031.1 - 6.2e-67 225.5 14.4 7.9e-67 225.2 14.4 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain Ribosomal_L27 PF01016.19 AMD20031.1 - 6.9e-32 109.3 0.1 1.1e-31 108.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein DDE_Tnp_IS66 PF03050.14 AMD20031.1 - 0.0085 15.6 0.2 0.016 14.7 0.2 1.5 1 0 0 1 1 1 1 Transposase IS66 family ALS_ss_C PF10369.9 AMD20032.1 - 1.1e-16 60.8 0.1 7e-16 58.2 0.0 2.2 2 1 1 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.25 AMD20032.1 - 7.2e-12 44.9 0.2 1.5e-11 43.8 0.2 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 AMD20032.1 - 7.2e-08 32.2 0.0 1.4e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 ACT domain Limkain-b1 PF11608.8 AMD20032.1 - 0.011 15.7 0.0 0.041 14.0 0.0 1.9 2 0 0 2 2 2 0 Limkain b1 ACT_4 PF13291.6 AMD20032.1 - 0.023 15.3 0.1 0.05 14.2 0.1 1.5 1 0 0 1 1 1 0 ACT domain Iso_dh PF00180.20 AMD20033.1 - 2.1e-73 247.5 0.0 2.4e-73 247.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HAD PF12710.7 AMD20034.1 - 1e-26 94.5 0.0 1.3e-26 94.2 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 AMD20034.1 - 1.1e-09 38.1 0.0 1.5e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 AMD20034.1 - 2.1e-07 30.7 0.0 4.8e-06 26.3 0.0 2.1 1 1 1 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.26 AMD20034.1 - 0.00011 22.5 0.0 0.016 15.5 0.0 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase UPF0052 PF01933.18 AMD20035.1 - 2e-59 201.3 0.0 2.4e-59 201.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 EF-hand_7 PF13499.6 AMD20036.1 - 5.7e-07 29.9 1.1 1.4e-06 28.6 1.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 AMD20036.1 - 8.9e-06 25.2 1.6 0.015 15.2 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 AMD20036.1 - 4.7e-05 22.6 4.2 0.0064 16.0 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 AMD20036.1 - 0.00099 18.9 3.3 0.54 10.1 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair PLA2_B PF01735.18 AMD20038.1 - 3.3e-93 312.7 6.4 1.3e-80 271.2 0.3 2.1 2 0 0 2 2 2 2 Lysophospholipase catalytic domain ABC_tran PF00005.27 AMD20039.1 - 2.6e-45 154.3 0.1 4e-23 82.4 0.0 4.6 3 2 0 3 3 3 2 ABC transporter 4HB PF17947.1 AMD20039.1 - 3.6e-29 100.7 0.6 1.4e-28 98.7 0.1 2.4 2 0 0 2 2 1 1 Four helical bundle domain AAA_21 PF13304.6 AMD20039.1 - 6e-18 65.7 0.2 0.0026 17.6 0.0 4.5 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AMD20039.1 - 2.9e-17 62.9 0.0 1.1e-06 28.3 0.0 4.0 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AMD20039.1 - 3.2e-11 44.1 3.9 0.00036 21.1 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 AMD20039.1 - 7.6e-09 35.2 0.0 0.0066 16.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 AMD20039.1 - 3.8e-08 33.7 0.1 0.0073 16.6 0.0 4.2 4 1 0 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 AMD20039.1 - 5.7e-08 32.8 0.0 0.0021 18.0 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 AMD20039.1 - 1.8e-07 31.6 0.1 0.0087 16.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 AMD20039.1 - 3.1e-07 30.5 0.2 0.0026 17.8 0.0 3.0 3 0 0 3 3 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 AMD20039.1 - 3.6e-07 30.4 0.0 1.7e-05 24.9 0.0 3.0 3 0 0 3 3 2 1 Dynamin family AAA PF00004.29 AMD20039.1 - 2.6e-06 27.9 0.1 0.78 10.2 0.0 4.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 AMD20039.1 - 1.2e-05 25.6 0.0 0.12 12.8 0.0 2.9 2 0 0 2 2 2 2 RNA helicase CLASP_N PF12348.8 AMD20039.1 - 3.2e-05 23.6 0.9 0.0027 17.3 0.4 2.7 1 1 1 2 2 2 1 CLASP N terminal AAA_33 PF13671.6 AMD20039.1 - 4.7e-05 23.6 0.0 0.6 10.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 AMD20039.1 - 5.7e-05 23.6 0.0 0.22 11.9 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_15 PF13175.6 AMD20039.1 - 6.2e-05 22.9 4.0 0.27 10.9 0.0 3.9 5 0 0 5 5 4 2 AAA ATPase domain AAA_18 PF13238.6 AMD20039.1 - 7e-05 23.4 0.0 0.93 10.0 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_27 PF13514.6 AMD20039.1 - 9.4e-05 22.1 0.0 0.075 12.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 AMD20039.1 - 0.00017 20.7 0.1 0.35 9.8 0.0 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB HEAT_2 PF13646.6 AMD20039.1 - 0.00017 21.9 0.0 0.027 14.9 0.0 2.9 1 1 1 2 2 2 1 HEAT repeats Rad17 PF03215.15 AMD20039.1 - 0.00024 21.1 0.0 0.6 10.0 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_30 PF13604.6 AMD20039.1 - 0.00041 20.1 0.1 0.97 9.1 0.0 3.4 4 0 0 4 4 3 1 AAA domain HEAT_EZ PF13513.6 AMD20039.1 - 0.00077 19.9 2.1 0.077 13.5 0.0 4.4 4 1 1 5 5 4 1 HEAT-like repeat SbcCD_C PF13558.6 AMD20039.1 - 0.00085 19.5 0.1 0.78 10.0 0.0 3.8 3 1 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 AMD20039.1 - 0.0015 18.6 0.0 2.5 8.1 0.0 3.2 3 0 0 3 3 2 1 AAA domain ATPase_2 PF01637.18 AMD20039.1 - 0.0015 18.4 0.1 2.1 8.2 0.0 3.2 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 AMD20039.1 - 0.0017 18.1 0.0 0.28 10.9 0.0 3.2 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 AMD20039.1 - 0.002 17.9 0.1 1.3 8.7 0.0 3.6 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 AMD20039.1 - 0.0028 17.3 0.2 1.5 8.4 0.0 3.1 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 AMD20039.1 - 0.0036 17.3 0.0 2 8.3 0.0 2.9 3 0 0 3 3 2 1 NACHT domain Vac14_Fab1_bd PF12755.7 AMD20039.1 - 0.0057 17.2 0.4 0.99 10.0 0.0 3.3 3 1 1 4 4 2 1 Vacuolar 14 Fab1-binding region UME PF08064.13 AMD20039.1 - 0.0073 16.2 0.5 0.053 13.4 0.9 2.2 2 0 0 2 2 1 1 UME (NUC010) domain ParcG PF10274.9 AMD20039.1 - 0.0088 16.2 0.5 3.1 7.9 0.0 2.6 2 0 0 2 2 2 0 Parkin co-regulated protein CLP1_P PF16575.5 AMD20039.1 - 0.0096 15.7 0.2 1.6 8.5 0.0 3.2 3 0 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Roc PF08477.13 AMD20039.1 - 0.013 15.7 0.0 8.7 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 AMD20039.1 - 0.017 14.5 0.3 2.6 7.4 0.0 3.4 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Ploopntkinase3 PF18751.1 AMD20039.1 - 0.018 15.0 0.0 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 IstB_IS21 PF01695.17 AMD20039.1 - 0.018 14.7 0.1 10 5.8 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding protein NTPase_1 PF03266.15 AMD20039.1 - 0.026 14.5 0.3 14 5.6 0.0 3.1 3 0 0 3 3 2 0 NTPase ATP_bind_1 PF03029.17 AMD20039.1 - 0.027 14.2 1.2 7.6 6.2 0.0 3.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF3437 PF11919.8 AMD20039.1 - 0.028 14.3 2.0 0.076 12.9 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3437) Cytidylate_kin PF02224.18 AMD20039.1 - 0.034 13.9 0.0 9.9 5.8 0.1 2.5 2 0 0 2 2 2 0 Cytidylate kinase AAA_17 PF13207.6 AMD20039.1 - 0.035 14.5 1.4 7.2 7.0 0.3 3.8 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 AMD20039.1 - 0.035 13.2 0.1 0.62 9.1 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 AMD20039.1 - 0.043 13.3 0.0 3.7 7.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 AMD20039.1 - 0.049 13.6 0.1 3.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Adeno_IVa2 PF02456.15 AMD20039.1 - 0.051 12.4 0.1 5 5.8 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein Zeta_toxin PF06414.12 AMD20039.1 - 0.062 12.6 1.0 13 5.0 0.0 3.2 4 0 0 4 4 3 0 Zeta toxin Septin PF00735.18 AMD20039.1 - 0.067 12.5 0.0 2.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Septin CRM1_C PF08767.11 AMD20039.1 - 0.067 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 CRM1 C terminal G-alpha PF00503.20 AMD20039.1 - 0.073 12.2 0.0 6.6 5.8 0.0 2.5 2 0 0 2 2 2 0 G-protein alpha subunit MukB PF04310.12 AMD20039.1 - 0.076 12.8 0.1 8.5 6.1 0.0 2.6 2 0 0 2 2 2 0 MukB N-terminal MutS_V PF00488.21 AMD20039.1 - 0.1 12.6 0.1 6.4 6.8 0.1 2.5 2 0 0 2 2 2 0 MutS domain V AAA_PrkA PF08298.11 AMD20039.1 - 0.12 11.3 0.0 9 5.1 0.0 2.3 2 0 0 2 2 2 0 PrkA AAA domain AAA_13 PF13166.6 AMD20039.1 - 0.24 10.0 10.0 1.5 7.4 0.0 4.3 5 0 0 5 5 5 0 AAA domain DUF87 PF01935.17 AMD20039.1 - 0.34 11.0 8.8 0.42 10.7 0.0 4.2 5 1 0 5 5 3 0 Helicase HerA, central domain HEAT PF02985.22 AMD20039.1 - 1.3 9.4 3.1 1.7e+02 2.9 0.0 4.7 5 0 0 5 5 3 0 HEAT repeat Pkinase PF00069.25 AMD20040.1 - 2e-57 194.6 0.0 3.1e-57 193.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20040.1 - 5.8e-23 81.5 0.0 2.5e-22 79.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20040.1 - 9.7e-05 21.8 0.1 0.34 10.2 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 AMD20040.1 - 0.00045 19.6 0.0 0.00078 18.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 AMD20040.1 - 0.029 14.0 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 NOA36 PF06524.12 AMD20040.1 - 9.1 5.5 6.3 16 4.7 6.3 1.4 1 0 0 1 1 1 0 NOA36 protein SNF2_N PF00176.23 AMD20041.1 - 3.1e-47 161.0 0.4 5.4e-47 160.2 0.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 AMD20041.1 - 2.9e-10 39.8 8.3 6.8e-10 38.6 8.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AMD20041.1 - 1e-09 38.6 8.7 3.8e-09 36.7 8.7 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AMD20041.1 - 2.6e-09 36.8 9.0 6.7e-09 35.5 9.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD20041.1 - 6.3e-09 35.6 7.1 1.3e-08 34.5 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AMD20041.1 - 1.1e-06 28.8 5.7 4e-06 27.0 5.7 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 AMD20041.1 - 1.5e-05 25.3 0.7 7.1e-05 23.1 0.1 2.6 2 0 0 2 2 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 AMD20041.1 - 7.5e-05 22.7 7.7 0.00019 21.4 7.7 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 AMD20041.1 - 8e-05 22.4 8.2 0.00016 21.5 8.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 AMD20041.1 - 0.00022 21.1 7.7 0.00052 19.9 7.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 AMD20041.1 - 0.00079 19.5 9.7 0.0023 18.0 9.7 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 AMD20041.1 - 0.0011 19.0 2.9 0.0011 19.0 2.9 2.4 3 0 0 3 3 2 1 zinc RING finger of MSL2 zf-RING_11 PF17123.5 AMD20041.1 - 0.18 11.5 6.5 0.52 10.1 6.5 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 AMD20041.1 - 0.19 11.8 2.4 0.51 10.4 2.4 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 AMD20041.1 - 4.5 7.0 6.9 18 5.1 6.9 2.0 1 0 0 1 1 1 0 P-11 zinc finger LisH PF08513.11 AMD20042.1 - 3.8e-08 33.0 1.7 6.9e-08 32.2 1.7 1.5 1 0 0 1 1 1 1 LisH LNS2 PF08235.13 AMD20043.1 - 3.2e-97 324.5 0.0 6.1e-97 323.5 0.0 1.5 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 AMD20043.1 - 7.4e-43 144.7 0.0 1.9e-42 143.4 0.0 1.8 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 AMD20043.1 - 0.027 14.1 0.0 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_6 PF13344.6 AMD20043.1 - 0.15 12.2 0.0 0.4 10.8 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Mito_carr PF00153.27 AMD20044.1 - 1.2e-66 220.7 2.9 6.1e-25 87.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PT-VENN PF04829.13 AMD20044.1 - 0.34 11.0 3.7 17 5.6 0.2 2.9 3 0 0 3 3 3 0 Pre-toxin domain with VENN motif Peptidase_M22 PF00814.25 AMD20045.1 - 4e-70 236.6 0.0 5.1e-70 236.3 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family COMPASS-Shg1 PF05205.12 AMD20045.1 - 0.079 13.7 0.1 3.8 8.3 0.0 2.4 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 Nse4_C PF08743.10 AMD20046.1 - 5.7e-30 103.4 0.1 1.7e-29 101.9 0.1 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 AMD20046.1 - 6.5e-15 55.0 0.2 8.7e-14 51.4 0.1 2.3 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE JUPITER PF17054.5 AMD20046.1 - 0.048 13.1 0.5 0.071 12.6 0.5 1.2 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Mlh1_C PF16413.5 AMD20047.1 - 4.8e-85 285.2 0.3 8.5e-85 284.4 0.3 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 AMD20047.1 - 2e-29 101.7 1.9 2.1e-29 101.6 0.2 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 AMD20047.1 - 7.1e-13 48.6 0.2 2.1e-12 47.0 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AMD20047.1 - 3.9e-06 27.3 0.1 1.2e-05 25.7 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cep3 PF16846.5 AMD20048.1 - 1.2e-180 601.4 12.6 1.5e-180 601.1 12.6 1.1 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Zn_clus PF00172.18 AMD20048.1 - 2.6e-07 30.6 11.3 5.8e-07 29.5 11.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.22 AMD20049.1 - 6.5e-160 532.6 0.0 7.3e-160 532.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Homeodomain PF00046.29 AMD20050.1 - 6.8e-20 70.7 2.7 1.3e-19 69.8 2.7 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AMD20050.1 - 0.00065 19.6 0.9 0.0016 18.3 0.9 1.7 1 0 0 1 1 1 1 Homeobox KN domain L_protein_N PF15518.6 AMD20050.1 - 0.025 14.4 0.2 0.064 13.1 0.2 1.7 1 0 0 1 1 1 0 L protein N-terminus SPRY PF00622.28 AMD20051.1 - 2.3e-12 47.1 0.1 4.8e-12 46.1 0.1 1.6 1 0 0 1 1 1 1 SPRY domain HECT PF00632.25 AMD20052.1 - 1.6e-83 280.8 1.1 2.5e-83 280.1 1.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 AMD20052.1 - 0.0061 16.3 0.6 0.014 15.1 0.6 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Glyco_transf_22 PF03901.17 AMD20053.1 - 1.7e-93 314.1 35.0 2.3e-93 313.7 35.0 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family TPR_16 PF13432.6 AMD20054.1 - 9.8e-06 26.1 3.2 0.0003 21.4 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD20054.1 - 0.012 15.7 9.3 5.7 7.3 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 AMD20054.1 - 0.014 15.6 13.3 3.8 8.0 0.1 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20054.1 - 0.11 13.0 2.0 0.86 10.2 0.0 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 AMD20054.1 - 0.4 11.0 7.4 7.4 6.9 0.2 4.3 2 1 3 5 5 5 0 Tetratricopeptide repeat Sel1 PF08238.12 AMD20054.1 - 2.1 9.2 8.7 28 5.6 2.6 4.1 4 1 0 4 4 4 0 Sel1 repeat Pkinase PF00069.25 AMD20055.1 - 2e-69 233.9 0.0 2.3e-69 233.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20055.1 - 8e-31 107.3 0.0 1e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20055.1 - 0.001 18.5 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD20055.1 - 0.012 15.5 0.1 0.035 14.0 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 AMD20055.1 - 0.072 12.1 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 AMD20055.1 - 0.19 10.5 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PCRF PF03462.18 AMD20056.1 - 1e-53 182.1 0.0 1e-53 182.1 0.0 2.2 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 AMD20056.1 - 1.1e-38 131.8 3.6 1.1e-38 131.8 3.6 2.0 3 0 0 3 3 3 1 RF-1 domain Mating_N PF12731.7 AMD20056.1 - 0.082 13.0 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Mating-type protein beta 1 DUF676 PF05057.14 AMD20057.1 - 4e-56 190.0 0.0 6.4e-56 189.3 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AMD20057.1 - 6.8e-05 22.8 0.0 0.00015 21.7 0.0 1.5 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 AMD20057.1 - 0.0016 18.3 0.0 0.0037 17.1 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 AMD20057.1 - 0.0062 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 AMD20057.1 - 0.033 13.4 0.0 0.073 12.2 0.0 1.5 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF432 PF04254.13 AMD20057.1 - 0.07 13.3 0.1 0.26 11.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF432) RINT1_TIP1 PF04437.13 AMD20058.1 - 4.3e-73 246.9 23.2 6.3e-73 246.4 23.2 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family FlaC_arch PF05377.11 AMD20058.1 - 0.23 11.9 3.8 9.2 6.8 0.4 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) LidA_Long_CC PF18641.1 AMD20058.1 - 0.84 9.7 5.1 2.7 8.0 1.2 2.8 3 0 0 3 3 3 0 LidA long coiled-coil domain COG2 PF06148.11 AMD20058.1 - 0.97 9.5 7.2 1.6 8.8 2.7 3.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 AMD20058.1 - 1.3 9.3 5.4 0.49 10.7 0.3 2.9 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF390 PF04094.14 AMD20058.1 - 3 6.0 3.1 4.4 5.5 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF390) DUF4061 PF13270.6 AMD20058.1 - 9.2 6.7 8.3 6.5 7.2 0.1 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4061) Chorismate_synt PF01264.21 AMD20059.1 - 9.5e-140 464.9 0.0 1.1e-139 464.8 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase SH3_1 PF00018.28 AMD20060.1 - 2.4e-06 27.0 0.1 7.5e-06 25.5 0.1 1.9 2 0 0 2 2 2 1 SH3 domain Transglut_core PF01841.19 AMD20060.1 - 0.015 15.7 0.0 0.038 14.4 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily Nup84_Nup100 PF04121.13 AMD20061.1 - 1.2e-178 595.6 15.6 1.4e-178 595.4 15.6 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 DUF4393 PF14337.6 AMD20061.1 - 0.045 13.5 0.7 0.12 12.2 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4393) TNFR_16_TM PF18422.1 AMD20061.1 - 0.047 13.7 0.3 8.3 6.5 0.0 3.1 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain Ribosomal_L6 PF00347.23 AMD20062.1 - 3e-32 111.1 11.1 5.3e-17 62.3 3.6 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Iwr1 PF08574.10 AMD20063.1 - 1.8e-14 54.5 10.8 1.8e-14 54.5 10.8 3.7 3 2 0 3 3 3 1 Transcription factor Iwr1 adh_short PF00106.25 AMD20064.1 - 3.2e-40 137.7 0.0 2.1e-38 131.8 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AMD20064.1 - 6.1e-22 78.3 0.0 3.6e-20 72.5 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD20064.1 - 3.1e-09 37.0 0.2 1.5e-05 25.0 0.0 2.1 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 AMD20064.1 - 0.00036 20.1 0.0 0.00051 19.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 AMD20064.1 - 0.019 14.0 0.1 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family AXE1 PF05448.12 AMD20064.1 - 0.19 10.4 0.0 0.31 9.7 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) PX PF00787.24 AMD20065.1 - 4.8e-21 74.9 0.1 1.9e-20 72.9 0.0 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 AMD20065.1 - 0.014 15.0 11.2 0.017 14.6 1.5 2.3 2 0 0 2 2 2 0 Vps5 C terminal like TFIIE_alpha PF02002.17 AMD20065.1 - 0.21 11.5 2.6 15 5.5 0.0 3.3 2 1 1 3 3 3 0 TFIIE alpha subunit SpoU_methylase PF00588.19 AMD20066.1 - 1.8e-25 89.7 0.0 4.9e-25 88.4 0.0 1.8 1 0 0 1 1 1 1 SpoU rRNA Methylase family RNase_PH PF01138.21 AMD20067.1 - 2.9e-07 31.0 0.0 5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AMD20067.1 - 3.3e-05 23.8 0.2 6.4e-05 22.9 0.2 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 EMP24_GP25L PF01105.24 AMD20068.1 - 1.1e-06 28.8 0.0 1.4e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SNARE PF05739.19 AMD20069.1 - 0.053 13.5 0.0 0.096 12.7 0.0 1.4 1 0 0 1 1 1 0 SNARE domain SNF2_N PF00176.23 AMD20070.1 - 2.3e-66 223.9 0.4 2.3e-66 223.9 0.4 2.3 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 AMD20070.1 - 1.6e-48 164.5 20.9 1.6e-48 164.5 20.9 5.0 6 0 0 6 6 6 1 DNA-binding domain Helicase_C PF00271.31 AMD20070.1 - 1.9e-18 66.8 0.3 1.2e-17 64.3 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD20070.1 - 2.9e-06 27.4 0.0 2.9e-06 27.4 0.0 3.7 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AMD20070.1 - 0.0015 18.3 0.0 0.0067 16.2 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Fe_hyd_lg_C PF02906.14 AMD20070.1 - 0.02 14.6 0.8 0.064 12.9 0.8 1.9 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain Med5 PF08689.10 AMD20071.1 - 0 1227.5 41.6 0 1227.2 41.6 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 SpoVG PF04026.12 AMD20071.1 - 0.087 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 SpoVG Pex14_N PF04695.13 AMD20072.1 - 2.1e-28 99.9 6.1 2.1e-28 99.9 6.1 3.6 3 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region COR PF16095.5 AMD20072.1 - 0.0035 17.2 0.1 0.012 15.5 0.0 1.9 2 1 0 2 2 2 1 C-terminal of Roc, COR, domain Myosin_tail_1 PF01576.19 AMD20072.1 - 0.0038 15.1 13.1 0.0067 14.3 13.1 1.3 1 0 0 1 1 1 1 Myosin tail DUF1043 PF06295.12 AMD20072.1 - 0.0053 16.8 10.8 0.0053 16.8 10.8 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF1043) MCPsignal PF00015.21 AMD20072.1 - 0.012 15.4 1.3 0.027 14.3 0.2 1.9 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Ead_Ea22 PF13935.6 AMD20072.1 - 0.018 15.7 9.5 0.044 14.5 9.5 1.7 1 1 0 1 1 1 0 Ead/Ea22-like protein Helo_like_N PF17111.5 AMD20072.1 - 0.061 12.7 5.6 0.5 9.7 0.2 2.4 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins DUF4407 PF14362.6 AMD20072.1 - 0.1 11.9 4.4 0.18 11.1 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nup88 PF10168.9 AMD20072.1 - 0.12 10.1 10.5 0.22 9.3 10.5 1.3 1 0 0 1 1 1 0 Nuclear pore component DUF948 PF06103.11 AMD20072.1 - 0.13 12.5 5.8 0.74 10.1 1.4 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Noelin-1 PF12308.8 AMD20072.1 - 0.25 11.4 5.6 0.12 12.4 2.6 2.0 2 1 0 2 2 2 0 Neurogenesis glycoprotein GTP-bdg_M PF16360.5 AMD20072.1 - 0.3 11.7 7.4 0.54 10.9 0.8 3.2 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region MbeD_MobD PF04899.12 AMD20072.1 - 0.35 11.0 6.4 0.15 12.2 2.7 2.3 2 1 1 3 3 3 0 MbeD/MobD like DUF1664 PF07889.12 AMD20072.1 - 0.38 10.8 9.9 0.66 10.0 6.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 AMD20072.1 - 0.63 8.9 21.4 0.039 12.8 15.3 2.0 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF5082 PF16888.5 AMD20072.1 - 1.6 9.0 11.2 0.22 11.8 6.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Seryl_tRNA_N PF02403.22 AMD20072.1 - 2.8 8.2 19.3 0.47 10.7 12.0 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Laminin_II PF06009.12 AMD20072.1 - 3.4 7.7 15.1 0.28 11.2 9.3 2.2 3 0 0 3 3 3 0 Laminin Domain II LXG PF04740.12 AMD20072.1 - 8.6 6.0 17.0 1.4 8.6 4.8 3.2 3 1 1 4 4 4 0 LXG domain of WXG superfamily NPV_P10 PF05531.12 AMD20072.1 - 9.1 6.8 9.0 7.5 7.1 3.4 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ACPS PF01648.20 AMD20073.1 - 6e-12 45.7 0.0 1.8e-11 44.2 0.0 1.8 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily BPL_N PF09825.9 AMD20074.1 - 2.2e-111 372.6 0.0 2.6e-111 372.3 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 AMD20074.1 - 2.1e-18 66.5 0.0 6e-18 65.0 0.0 1.8 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 AMD20074.1 - 8.4e-11 41.6 0.0 1.7e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain RNA_pol_Rpb1_1 PF04997.12 AMD20075.1 - 1e-114 383.1 0.0 2.1e-114 382.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 AMD20075.1 - 5.6e-108 360.4 0.3 8.5e-108 359.8 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AMD20075.1 - 2e-78 262.3 0.0 5.5e-78 260.9 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 AMD20075.1 - 5.9e-62 208.9 0.4 5.9e-62 208.9 0.4 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 AMD20075.1 - 2.5e-48 163.5 3.5 5.8e-48 162.3 3.5 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 AMD20075.1 - 3e-48 163.7 0.0 1.8e-47 161.2 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 AMD20075.1 - 1.5e-35 121.4 0.1 3.8e-35 120.1 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 AMD20075.1 - 6.9e-13 48.2 296.6 0.069 13.5 11.6 14.2 11 1 0 14 14 14 13 RNA polymerase Rpb1 C-terminal repeat Pro_isomerase PF00160.21 AMD20076.1 - 1.1e-46 159.0 0.1 1.8e-46 158.3 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 AMD20076.1 - 6.3e-08 32.1 2.4 1.4e-05 24.7 0.3 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD20076.1 - 1.8e-07 30.7 4.3 0.00016 21.5 0.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 AMD20076.1 - 0.005 17.0 0.9 0.0099 16.0 0.9 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 AMD20076.1 - 0.0055 16.8 0.2 0.0055 16.8 0.2 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 AMD20076.1 - 0.041 14.5 4.2 0.063 13.9 0.2 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 AMD20076.1 - 0.09 12.9 2.0 0.17 12.0 0.1 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 AMD20076.1 - 0.11 13.2 2.7 0.16 12.6 1.6 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Scm3 PF10384.9 AMD20077.1 - 1.4e-19 69.5 0.5 1.4e-19 69.5 0.5 2.1 2 0 0 2 2 2 1 Centromere protein Scm3 DUF4637 PF15470.6 AMD20077.1 - 3.6 7.3 11.7 0.95 9.2 8.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) TRAP_alpha PF03896.16 AMD20077.1 - 8.1 5.6 7.7 12 5.0 7.7 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CHCH PF06747.13 AMD20078.1 - 0.0041 17.2 2.1 0.0084 16.2 2.1 1.6 1 0 0 1 1 1 1 CHCH domain Sec31 PF11549.8 AMD20079.1 - 3.8e-22 77.9 1.7 1.8e-21 75.8 1.7 2.3 1 0 0 1 1 1 1 Protein transport protein SEC31 ANAPC4_WD40 PF12894.7 AMD20079.1 - 2.6e-09 37.3 0.9 0.074 13.4 0.1 3.8 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD20079.1 - 6e-09 36.4 6.8 0.0041 17.9 0.3 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat SRA1 PF07304.11 AMD20079.1 - 7.6e-09 35.5 0.0 7.6e-09 35.5 0.0 3.7 4 1 1 5 5 5 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 AMD20079.1 - 2.9e-07 30.5 2.0 8.9e-07 28.8 1.3 2.1 2 1 0 2 2 2 1 Sec23-binding domain of Sec16 Prp18 PF02840.15 AMD20079.1 - 0.0023 18.0 0.1 0.0085 16.2 0.1 2.0 1 1 0 1 1 1 1 Prp18 domain Trp_dioxygenase PF03301.13 AMD20079.1 - 0.039 13.3 0.1 0.093 12.0 0.1 1.5 1 0 0 1 1 1 0 Tryptophan 2,3-dioxygenase MmlI PF09448.10 AMD20079.1 - 0.19 12.2 0.0 0.42 11.1 0.0 1.5 1 0 0 1 1 1 0 Methylmuconolactone methyl-isomerase Clathrin PF00637.20 AMD20079.1 - 0.55 10.1 6.6 5.1 7.0 0.1 3.5 4 0 0 4 4 4 0 Region in Clathrin and VPS DUF5099 PF17025.5 AMD20080.1 - 0.024 15.1 0.0 0.047 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5099) Arf PF00025.21 AMD20081.1 - 2.4e-30 105.3 0.0 2.9e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD20081.1 - 0.0017 18.4 0.0 0.039 14.0 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 AMD20081.1 - 0.0038 17.4 0.0 0.0088 16.3 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AMD20081.1 - 0.01 15.4 0.0 0.031 13.9 0.0 1.7 1 1 0 1 1 1 0 Ras family SRPRB PF09439.10 AMD20081.1 - 0.015 14.7 0.0 1.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 AMD20081.1 - 0.023 15.2 0.1 0.13 12.8 0.1 2.1 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 AMD20081.1 - 0.17 11.0 0.1 0.29 10.2 0.1 1.3 1 1 0 1 1 1 0 G-protein alpha subunit MutS_V PF00488.21 AMD20081.1 - 0.24 11.4 0.0 0.36 10.8 0.0 1.2 1 0 0 1 1 1 0 MutS domain V Arf PF00025.21 AMD20082.1 - 2.2e-79 265.0 0.0 2.5e-79 264.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 AMD20082.1 - 8.3e-15 54.7 0.0 1e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AMD20082.1 - 2.4e-14 53.6 0.0 3.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AMD20082.1 - 8.8e-14 51.4 0.0 9.5e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 AMD20082.1 - 2.4e-13 50.0 1.2 1.3e-09 37.7 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 AMD20082.1 - 8.1e-11 41.7 0.0 1e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AMD20082.1 - 1.1e-05 25.5 0.0 1.7e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 AMD20082.1 - 0.0077 15.9 0.5 0.015 14.9 0.2 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 AMD20082.1 - 0.017 15.0 0.1 2.8 7.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 AMD20082.1 - 0.021 14.4 0.5 5 6.7 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 AMD20082.1 - 0.041 14.1 0.3 0.065 13.4 0.3 1.6 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 AMD20082.1 - 0.056 12.7 1.4 0.41 9.9 1.4 2.0 1 1 0 1 1 1 0 6-phosphofructo-2-kinase NACHT PF05729.12 AMD20082.1 - 0.1 12.5 0.6 8.5 6.3 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 AMD20082.1 - 0.14 12.7 0.1 0.31 11.6 0.1 1.7 1 1 0 1 1 1 0 ABC transporter Thymidylate_kin PF02223.17 AMD20082.1 - 0.15 11.8 0.8 0.97 9.1 0.3 2.0 2 0 0 2 2 2 0 Thymidylate kinase AAA_18 PF13238.6 AMD20082.1 - 0.15 12.6 0.1 0.23 12.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain Ribosomal_L29 PF00831.23 AMD20083.1 - 1.2e-16 60.4 2.6 1.2e-16 60.4 2.6 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein Phage_sheath_1C PF17482.2 AMD20083.1 - 0.029 14.4 0.2 0.045 13.7 0.2 1.3 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain AA_permease_N PF08403.10 AMD20083.1 - 0.13 11.8 0.1 0.23 11.0 0.1 1.4 1 0 0 1 1 1 0 Amino acid permease N-terminal IL2 PF00715.17 AMD20083.1 - 0.67 9.9 3.5 1.5 8.8 1.4 1.9 1 1 1 2 2 2 0 Interleukin 2 FlxA PF14282.6 AMD20083.1 - 2.8 8.0 9.4 0.53 10.3 5.1 1.8 1 1 1 2 2 2 0 FlxA-like protein Ufd2P_core PF10408.9 AMD20084.1 - 3.2e-197 657.0 13.6 3.2e-197 657.0 13.6 1.5 2 0 0 2 2 2 1 Ubiquitin elongating factor core U-box PF04564.15 AMD20084.1 - 2.1e-29 101.5 1.5 5.6e-29 100.1 1.5 1.8 1 0 0 1 1 1 1 U-box domain Rho_GDI PF02115.17 AMD20085.1 - 1.2e-60 204.7 1.7 1.3e-60 204.5 1.7 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor MucBP_2 PF17965.1 AMD20085.1 - 0.17 12.5 0.7 16 6.2 0.0 3.0 3 0 0 3 3 3 0 Mucin binding domain Metallophos PF00149.28 AMD20086.1 - 1.6e-33 116.9 0.3 2.8e-33 116.2 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ATP-synt_ab PF00006.25 AMD20088.1 - 5.5e-113 375.9 0.0 8.5e-113 375.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Hom_end_hint PF05203.16 AMD20088.1 - 1.5e-71 241.0 0.0 2.6e-71 240.2 0.0 1.4 1 0 0 1 1 1 1 Hom_end-associated Hint ATP-synt_ab_Xtn PF16886.5 AMD20088.1 - 2.9e-45 153.0 0.0 5.9e-45 152.0 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 AMD20088.1 - 1e-15 58.0 3.2 2.6e-15 56.7 3.2 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Hom_end PF05204.14 AMD20088.1 - 1.4e-10 41.3 0.1 2.1e-09 37.5 0.0 2.4 2 0 0 2 2 2 1 Homing endonuclease Hint PF01079.20 AMD20088.1 - 0.00062 19.3 0.0 0.0015 18.1 0.0 1.6 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.6 AMD20088.1 - 0.0012 19.1 0.0 0.0032 17.8 0.0 1.8 1 0 0 1 1 1 1 Hint domain Cas_St_Csn2 PF16813.5 AMD20088.1 - 0.063 12.4 0.2 0.11 11.5 0.2 1.3 1 0 0 1 1 1 0 CRISPR-associated protein Csn2 subfamily St Ribosomal_L41 PF05162.13 AMD20089.1 - 1.3e-11 44.3 26.2 1.4e-11 44.3 26.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L41 Mit_KHE1 PF10173.9 AMD20090.1 - 3.1e-53 180.7 4.0 3.1e-53 180.7 4.0 1.6 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related DPPIV_rep PF18811.1 AMD20090.1 - 0.11 12.5 0.4 0.32 11.0 0.0 1.9 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) low complexity region MARVEL PF01284.23 AMD20091.1 - 0.0061 16.6 2.5 0.0099 15.9 2.5 1.3 1 0 0 1 1 1 1 Membrane-associating domain Cwf_Cwc_15 PF04889.12 AMD20091.1 - 0.012 15.4 2.7 0.019 14.7 2.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3671 PF12420.8 AMD20091.1 - 0.15 12.1 1.5 0.5 10.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function Vma12 PF11712.8 AMD20091.1 - 0.18 11.9 0.4 0.42 10.7 0.0 1.9 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Androgen_recep PF02166.16 AMD20091.1 - 0.56 9.0 2.0 0.84 8.4 2.0 1.2 1 0 0 1 1 1 0 Androgen receptor PBP1_TM PF14812.6 AMD20091.1 - 2.8 8.4 6.0 12 6.3 2.0 3.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Use1 PF09753.9 AMD20091.1 - 9.7 5.8 9.2 0.12 12.0 1.5 1.8 2 0 0 2 2 2 0 Membrane fusion protein Use1 Cullin PF00888.22 AMD20092.1 - 1.4e-147 493.0 14.9 1.8e-147 492.7 14.9 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 AMD20092.1 - 3.3e-23 81.5 0.9 1.4e-22 79.5 0.9 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain Penicillinase_R PF03965.16 AMD20092.1 - 0.041 14.2 0.1 0.42 11.0 0.0 2.7 2 0 0 2 2 2 0 Penicillinase repressor DUF2087 PF09860.9 AMD20092.1 - 0.1 12.8 0.5 3.6 7.8 0.1 3.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) HMGL-like PF00682.19 AMD20093.1 - 1.7e-83 280.2 0.1 2.6e-83 279.6 0.1 1.3 1 0 0 1 1 1 1 HMGL-like IATP PF04568.12 AMD20094.1 - 1.4e-14 54.2 1.3 1.4e-14 54.2 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Trimer_CC PF08954.11 AMD20094.1 - 0.0047 16.4 8.0 0.01 15.4 8.0 1.5 1 0 0 1 1 1 1 Trimerisation motif Fib_alpha PF08702.10 AMD20094.1 - 0.0084 16.3 1.6 0.0086 16.3 1.6 1.1 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF4140 PF13600.6 AMD20094.1 - 0.044 14.2 0.6 0.044 14.2 0.6 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) PspB PF06667.12 AMD20094.1 - 0.82 9.8 5.1 0.99 9.5 5.1 1.1 1 0 0 1 1 1 0 Phage shock protein B XhlA PF10779.9 AMD20094.1 - 2.1 8.6 5.1 2 8.7 4.4 1.4 1 1 0 1 1 1 0 Haemolysin XhlA Ribosomal_60s PF00428.19 AMD20095.1 - 1e-23 83.7 9.3 1.2e-23 83.5 9.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Myc-LZ PF02344.15 AMD20096.1 - 0.0063 16.6 0.2 0.043 13.9 0.0 2.3 2 0 0 2 2 2 1 Myc leucine zipper domain Na_Ca_ex PF01699.24 AMD20098.1 - 9.9e-46 155.4 41.0 7.8e-25 87.6 11.6 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Cyclin_N PF00134.23 AMD20099.1 - 1e-16 60.8 0.0 1.5e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AMD20099.1 - 4.5e-08 33.6 0.0 7.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin AAA PF00004.29 AMD20100.1 - 3e-98 325.4 0.0 2.8e-48 163.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD20100.1 - 4.1e-25 87.3 5.8 3.1e-13 49.3 0.4 2.9 2 1 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AMD20100.1 - 3.4e-17 62.4 0.7 7.9e-17 61.2 0.2 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 AMD20100.1 - 7.5e-14 51.8 0.0 1.3e-05 25.0 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AMD20100.1 - 1.9e-13 50.9 0.0 5.6e-07 29.8 0.0 2.9 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AMD20100.1 - 4e-13 50.1 0.2 0.00012 22.5 0.0 5.0 3 2 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 AMD20100.1 - 1.6e-11 44.6 0.0 1.3e-05 25.4 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 AMD20100.1 - 2.7e-11 43.6 1.5 1e-05 25.6 0.1 3.8 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 AMD20100.1 - 6.6e-10 38.6 0.1 3.6e-09 36.3 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 AMD20100.1 - 2.4e-09 36.9 0.2 0.0018 17.5 0.0 2.7 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_22 PF13401.6 AMD20100.1 - 8.5e-09 35.8 0.9 0.071 13.4 0.0 4.2 2 2 2 4 4 4 2 AAA domain AAA_14 PF13173.6 AMD20100.1 - 1e-07 32.0 0.0 0.021 14.9 0.0 3.7 4 0 0 4 4 4 2 AAA domain RNA_helicase PF00910.22 AMD20100.1 - 2.5e-07 31.0 0.0 0.012 16.0 0.0 3.1 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.21 AMD20100.1 - 4e-07 29.6 0.4 0.032 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Vps4_C PF09336.10 AMD20100.1 - 4.1e-07 29.9 1.8 3e-05 23.9 0.1 3.1 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 AMD20100.1 - 8.3e-07 28.9 0.0 0.031 14.0 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase PF06745.13 AMD20100.1 - 2.4e-06 27.1 1.5 0.31 10.4 0.0 3.8 2 1 0 3 3 3 2 KaiC AAA_7 PF12775.7 AMD20100.1 - 4.6e-06 26.3 0.1 0.059 12.9 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 AMD20100.1 - 5.3e-06 27.0 0.0 0.22 12.1 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 AMD20100.1 - 5.5e-06 26.2 0.0 0.079 12.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 AMD20100.1 - 8.2e-06 25.5 4.3 0.04 13.5 0.2 4.2 2 2 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 AMD20100.1 - 1.5e-05 24.8 0.1 0.18 11.5 0.0 3.5 3 1 0 3 3 2 2 Sigma-54 interaction domain ABC_tran PF00005.27 AMD20100.1 - 1.6e-05 25.4 0.1 0.027 15.0 0.0 3.6 3 1 0 3 3 2 1 ABC transporter PhoH PF02562.16 AMD20100.1 - 2.5e-05 23.8 0.2 0.16 11.4 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_28 PF13521.6 AMD20100.1 - 3.1e-05 24.3 0.1 0.57 10.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain Parvo_NS1 PF01057.17 AMD20100.1 - 3.8e-05 22.9 0.1 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 AMD20100.1 - 6e-05 23.0 0.0 0.12 12.2 0.0 2.9 3 0 0 3 3 2 1 Bacterial dnaA protein AAA_11 PF13086.6 AMD20100.1 - 7.9e-05 22.6 0.9 0.75 9.5 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.6 AMD20100.1 - 9.2e-05 22.9 0.1 0.57 10.6 0.0 3.4 3 0 0 3 3 2 2 AAA domain DUF815 PF05673.13 AMD20100.1 - 0.00013 21.3 0.0 0.15 11.2 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_3 PF07726.11 AMD20100.1 - 0.00017 21.5 0.0 0.8 9.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 AMD20100.1 - 0.00031 20.8 0.0 0.66 10.0 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 AMD20100.1 - 0.00034 20.6 0.0 0.092 12.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 AMD20100.1 - 0.00065 19.0 0.0 1 8.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 AMD20100.1 - 0.0013 18.4 0.3 2.5 7.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AMD20100.1 - 0.0019 18.1 0.2 2.2 8.1 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.6 AMD20100.1 - 0.0023 18.3 0.8 3 8.2 0.0 3.2 2 1 1 3 3 2 1 AAA domain ATPase_2 PF01637.18 AMD20100.1 - 0.0041 17.1 2.0 20 5.0 0.0 3.7 3 1 1 4 4 3 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 AMD20100.1 - 0.0075 15.6 0.1 2 7.6 0.1 2.7 2 0 0 2 2 2 1 Zeta toxin Sigma54_activ_2 PF14532.6 AMD20100.1 - 0.013 15.6 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 AMD20100.1 - 0.017 14.5 0.1 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase NB-ARC PF00931.22 AMD20100.1 - 0.029 13.5 0.1 4.9 6.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Zot PF05707.12 AMD20100.1 - 0.038 13.6 0.0 2.8 7.5 0.0 3.2 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) KAP_NTPase PF07693.14 AMD20100.1 - 0.041 13.1 0.3 1.9 7.6 0.0 2.8 2 2 0 2 2 2 0 KAP family P-loop domain NTPase_1 PF03266.15 AMD20100.1 - 0.07 13.0 1.4 8.2 6.3 0.0 3.8 4 0 0 4 4 3 0 NTPase AAA_6 PF12774.7 AMD20100.1 - 0.11 11.4 0.4 5.6 5.8 0.0 2.5 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region Viral_helicase1 PF01443.18 AMD20100.1 - 0.15 11.8 0.0 19 4.9 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase HIT PF01230.23 AMD20101.1 - 8.2e-24 84.2 0.0 1.1e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AMD20101.1 - 1.3e-09 38.5 0.3 2.4e-09 37.7 0.0 1.5 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding AA_permease PF00324.21 AMD20102.1 - 1.4e-119 399.8 35.4 1.8e-119 399.5 35.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD20102.1 - 8.9e-25 87.4 38.5 1.1e-24 87.1 38.5 1.0 1 0 0 1 1 1 1 Amino acid permease FAD-oxidase_C PF02913.19 AMD20103.1 - 3.3e-59 200.5 0.0 4.3e-59 200.2 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 AMD20103.1 - 9.5e-36 122.6 0.4 2.4e-35 121.3 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain UPF0029 PF01205.19 AMD20104.1 - 2.8e-30 104.8 0.0 3.5e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Pmp3 PF01679.17 AMD20106.1 - 3e-19 69.0 8.2 4e-19 68.6 8.2 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator P3A PF08727.11 AMD20106.1 - 0.075 12.4 0.3 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 Poliovirus 3A protein like MAM33 PF02330.16 AMD20107.1 - 1.5e-56 191.7 4.9 1.8e-56 191.5 4.9 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein HHH_2 PF12826.7 AMD20107.1 - 0.13 12.3 0.2 0.5 10.5 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif PPR_2 PF13041.6 AMD20108.1 - 9.4e-10 38.5 7.6 8.5e-09 35.5 0.1 4.2 3 1 1 4 4 4 2 PPR repeat family PCI PF01399.27 AMD20109.1 - 0.033 14.7 3.2 0.049 14.2 0.5 2.5 2 1 0 2 2 2 0 PCI domain US30 PF17624.2 AMD20109.1 - 0.19 10.7 0.1 0.33 10.0 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function CSN8_PSD8_EIF3K PF10075.9 AMD20109.1 - 0.64 10.0 4.7 0.23 11.4 0.7 2.2 3 0 0 3 3 3 0 CSN8/PSMD8/EIF3K family Peptidase_M24 PF00557.24 AMD20110.1 - 2.7e-52 177.5 0.0 3.7e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 AMD20110.1 - 3.2e-36 123.8 0.0 6.9e-36 122.7 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NAD_binding_8 PF13450.6 AMD20110.1 - 0.022 15.0 0.1 0.084 13.1 0.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HORMA PF02301.18 AMD20111.1 - 2.2e-61 207.1 0.1 4e-61 206.3 0.1 1.4 1 0 0 1 1 1 1 HORMA domain PHD_2 PF13831.6 AMD20111.1 - 0.1 12.2 4.8 0.24 11.0 4.8 1.6 1 0 0 1 1 1 0 PHD-finger PHD PF00628.29 AMD20111.1 - 2.2 8.2 10.9 5 7.1 10.9 1.6 1 0 0 1 1 1 0 PHD-finger Cnd1 PF12717.7 AMD20112.1 - 4.9e-51 173.0 17.1 8.2e-46 156.0 0.4 5.6 7 1 1 8 8 8 3 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 AMD20112.1 - 1.6e-40 138.7 4.0 6.5e-40 136.7 0.4 2.9 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_2 PF13646.6 AMD20112.1 - 2.8e-13 50.0 0.1 0.00021 21.6 0.0 4.5 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 AMD20112.1 - 8.4e-13 47.4 4.3 0.097 13.0 0.0 6.9 7 0 0 7 7 7 4 HEAT repeat Cnd3 PF12719.7 AMD20112.1 - 3.8e-08 32.9 6.2 1.1e-05 24.8 1.2 4.0 3 1 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 AMD20112.1 - 4.1e-07 30.4 1.4 0.49 10.9 0.0 5.6 5 0 0 5 5 5 1 HEAT-like repeat RTP1_C1 PF10363.9 AMD20112.1 - 0.0032 17.6 5.6 0.48 10.6 0.0 4.9 4 1 1 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 FemAB_like PF04339.12 AMD20112.1 - 0.12 11.4 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition Ferrochelatase PF00762.19 AMD20113.1 - 1.1e-96 323.7 0.0 1.3e-96 323.4 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase MBOAT PF03062.19 AMD20114.1 - 3.8e-47 161.3 8.8 1.1e-46 159.8 8.7 1.8 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF1925 PF09094.11 AMD20114.1 - 0.18 12.1 1.3 0.3 11.4 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1925) Med4 PF10018.9 AMD20115.1 - 1e-33 116.7 2.4 2e-33 115.7 2.4 1.5 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 DsrC PF04358.13 AMD20115.1 - 0.059 13.9 0.1 0.1 13.1 0.1 1.4 1 0 0 1 1 1 0 DsrC like protein DUF4187 PF13821.6 AMD20116.1 - 9.2e-19 67.0 3.2 9.2e-19 67.0 3.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.23 AMD20116.1 - 1.1e-05 25.2 0.8 2.2e-05 24.3 0.8 1.4 1 0 0 1 1 1 1 G-patch domain DcpS PF05652.12 AMD20117.1 - 6.7e-34 116.9 0.1 1e-33 116.3 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 AMD20117.1 - 1.4e-33 115.7 0.0 2.7e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 AMD20117.1 - 0.012 16.3 0.1 0.044 14.5 0.0 1.9 2 0 0 2 2 2 0 HIT domain Longin PF13774.6 AMD20118.1 - 5.3e-20 71.3 0.1 7.8e-20 70.7 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 AMD20118.1 - 2.4e-14 52.9 0.0 4.6e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin PP_kinase_C_1 PF17941.1 AMD20118.1 - 0.058 12.9 0.0 0.096 12.2 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 1 NUDIX PF00293.28 AMD20119.1 - 2.1e-19 69.9 0.2 2.7e-19 69.5 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain DUF410 PF04190.13 AMD20120.1 - 1.8e-67 227.9 0.1 2.3e-67 227.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF410) SNAP PF14938.6 AMD20120.1 - 0.0075 15.7 0.4 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP RHD3 PF05879.12 AMD20121.1 - 7.9e-228 758.3 26.4 1e-227 758.0 26.4 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 AMD20121.1 - 2.3e-05 24.4 0.4 9.6e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AMD20121.1 - 6.1e-05 23.1 5.2 6.1e-05 23.1 0.0 3.0 3 0 0 3 3 3 1 Dynamin family Septin PF00735.18 AMD20121.1 - 0.00029 20.2 0.1 0.001 18.4 0.1 1.9 1 0 0 1 1 1 1 Septin Roc PF08477.13 AMD20121.1 - 0.011 15.9 0.2 0.052 13.8 0.2 2.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 AMD20121.1 - 0.018 15.3 0.0 0.048 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain WcbI PF18588.1 AMD20121.1 - 0.018 14.7 0.6 0.047 13.3 0.3 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis enzyme WcbI AAA_14 PF13173.6 AMD20121.1 - 0.19 11.8 2.6 0.9 9.6 0.0 3.3 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 AMD20121.1 - 0.27 11.8 2.2 0.76 10.3 0.0 2.6 3 0 0 3 3 3 0 ABC transporter XLF PF09302.11 AMD20122.1 - 0.025 14.7 0.0 0.056 13.6 0.0 1.6 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component PCIF1_WW PF12237.8 AMD20122.1 - 0.16 11.6 0.2 0.34 10.5 0.0 1.6 2 0 0 2 2 2 0 Phosphorylated CTD interacting factor 1 WW domain PIN_4 PF13638.6 AMD20123.1 - 1.1e-32 113.1 0.2 2.8e-32 111.7 0.1 1.8 2 0 0 2 2 2 1 PIN domain PIN_9 PF18477.1 AMD20123.1 - 0.047 14.0 0.0 0.36 11.2 0.0 2.4 1 1 0 1 1 1 0 PIN like domain Ribosomal_S28e PF01200.18 AMD20124.1 - 2.7e-32 110.5 1.8 3e-32 110.4 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Red1 PF07964.11 AMD20125.1 - 3.9e-159 531.3 29.0 4.9e-159 531.0 29.0 1.1 1 0 0 1 1 1 1 Rec10 / Red1 tRNA-synt_1c PF00749.21 AMD20126.1 - 1.4e-114 382.2 0.0 2.1e-114 381.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 AMD20126.1 - 1.5e-53 181.2 1.5 2.5e-53 180.4 1.5 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 AMD20126.1 - 6.9e-34 117.2 0.0 5.1e-32 111.1 0.0 2.4 1 1 1 2 2 2 2 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 AMD20126.1 - 1.4e-13 51.6 0.8 5.3e-13 49.7 0.8 2.0 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TMA7 PF09072.10 AMD20127.1 - 1.8e-24 86.3 18.2 2e-24 86.2 18.2 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Ras PF00071.22 AMD20128.1 - 3.7e-54 182.7 2.0 4.3e-54 182.5 2.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD20128.1 - 4.5e-36 123.7 0.1 8e-36 122.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD20128.1 - 7.4e-17 61.4 0.9 1.1e-16 60.8 0.9 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD20128.1 - 6.6e-06 26.2 0.0 1.3e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AMD20128.1 - 1.9e-05 24.3 0.3 0.00031 20.3 0.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 AMD20128.1 - 5.9e-05 22.5 0.4 7.6e-05 22.2 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AMD20128.1 - 0.00069 19.1 0.0 0.0013 18.2 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AMD20128.1 - 0.0015 18.4 0.6 1.7 8.6 0.2 2.3 2 1 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 AMD20128.1 - 0.081 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DAGK_cat PF00781.24 AMD20129.1 - 1.6e-25 89.2 0.0 2.4e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain ATG22 PF11700.8 AMD20130.1 - 5.5e-114 381.4 22.4 6.5e-114 381.2 22.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like OapA_N PF08525.11 AMD20130.1 - 0.19 11.7 0.1 0.19 11.7 0.1 2.6 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif Cpn60_TCP1 PF00118.24 AMD20131.1 - 9.1e-85 285.1 10.9 8.6e-84 281.9 10.9 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cnn_1N PF07989.11 AMD20131.1 - 0.22 11.7 1.9 0.76 10.0 0.0 2.8 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 RNA_pol_I_TF PF04090.12 AMD20132.1 - 1.1e-60 204.6 1.7 1.1e-60 204.6 1.7 1.8 2 0 0 2 2 2 1 RNA polymerase I specific initiation factor DAG1 PF05454.11 AMD20132.1 - 0.13 11.6 0.6 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) zf-RING_2 PF13639.6 AMD20133.1 - 1.5e-11 44.5 6.3 3.6e-11 43.2 6.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 AMD20133.1 - 1.6e-07 31.1 3.3 2.8e-07 30.3 3.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD20133.1 - 2e-07 30.8 3.3 3.7e-07 30.0 3.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 AMD20133.1 - 2.7e-07 30.8 5.8 2.7e-07 30.8 5.8 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 AMD20133.1 - 3e-06 27.2 3.7 6.2e-06 26.1 3.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AMD20133.1 - 4.1e-06 26.5 6.1 9.5e-06 25.4 6.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD20133.1 - 5.3e-05 23.0 10.1 0.00026 20.7 10.1 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AMD20133.1 - 7.1e-05 22.6 4.1 0.00016 21.5 4.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Pox_A_type_inc PF04508.12 AMD20133.1 - 0.0019 18.0 5.1 0.0044 16.8 5.1 1.6 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat Zn_ribbon_17 PF17120.5 AMD20133.1 - 0.002 17.7 0.2 0.002 17.7 0.2 1.6 2 0 0 2 2 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 AMD20133.1 - 0.0061 16.3 2.0 0.0061 16.3 2.0 2.5 2 1 0 2 2 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 AMD20133.1 - 0.055 13.5 3.8 0.19 11.8 3.8 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 AMD20133.1 - 0.11 12.7 3.2 0.65 10.2 3.2 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain CTU2 PF10288.9 AMD20133.1 - 0.12 12.6 5.6 1.7 8.9 5.6 2.3 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 TSC22 PF01166.18 AMD20133.1 - 0.13 12.6 3.2 0.48 10.8 1.8 2.5 1 1 1 2 2 2 0 TSC-22/dip/bun family zf-RING-like PF08746.11 AMD20133.1 - 0.34 11.2 1.2 0.86 10.0 1.2 1.7 1 0 0 1 1 1 0 RING-like domain HalX PF08663.10 AMD20133.1 - 0.43 10.9 4.5 0.083 13.2 0.8 1.8 2 0 0 2 2 1 0 HalX domain zf-C2HC5 PF06221.13 AMD20133.1 - 0.47 10.5 2.7 2.2 8.3 2.7 2.0 1 1 1 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-C3HC4_4 PF15227.6 AMD20133.1 - 0.49 10.6 4.8 0.12 12.6 1.0 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.14 AMD20133.1 - 1.3 8.7 6.0 0.4 10.4 2.1 2.1 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_4 PF14570.6 AMD20133.1 - 1.4 8.8 4.1 3.2 7.6 4.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 AMD20133.1 - 2.3 8.4 5.2 9.9 6.4 5.3 2.0 1 1 0 1 1 1 0 RING-variant domain DASH_Spc19 PF08287.11 AMD20133.1 - 2.6 7.9 8.5 0.09 12.7 1.5 1.9 2 0 0 2 2 2 0 Spc19 Uds1 PF15456.6 AMD20133.1 - 3.4 7.9 6.8 0.35 11.1 2.1 1.7 2 0 0 2 2 1 0 Up-regulated During Septation OPA3 PF07047.12 AMD20134.1 - 1.1e-41 141.5 2.2 1.3e-41 141.2 2.2 1.0 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DUF3967 PF13152.6 AMD20134.1 - 0.011 15.4 1.6 0.011 15.4 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3967) Histone PF00125.24 AMD20135.1 - 1.2e-16 61.3 0.0 1.4e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 AMD20135.1 - 5.1e-14 51.7 0.3 8.3e-14 51.0 0.3 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 AMD20135.1 - 9.6e-05 22.6 0.0 0.00013 22.2 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF4 PF05236.14 AMD20136.1 - 5.1e-53 180.6 4.5 1.3e-52 179.3 4.5 1.7 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Endonuc-BglII PF09195.11 AMD20136.1 - 0.085 12.7 0.0 0.34 10.7 0.0 2.0 1 1 1 2 2 2 0 Restriction endonuclease BglII RTC PF01137.21 AMD20137.1 - 4.7e-46 156.8 0.0 5.5e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 AMD20137.1 - 4.1e-28 97.9 0.0 7.9e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain PX PF00787.24 AMD20138.1 - 7.8e-21 74.2 0.1 2.1e-20 72.8 0.1 1.7 1 0 0 1 1 1 1 PX domain Latarcin PF10279.9 AMD20138.1 - 0.026 14.9 5.1 2.1 8.8 0.9 2.8 2 1 0 2 2 2 0 Latarcin precursor DUF919 PF06034.11 AMD20138.1 - 0.95 9.3 5.2 0.36 10.7 0.3 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) MMM1 PF10296.9 AMD20139.1 - 8e-09 35.0 0.1 1.1e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 EF-hand_2 PF09068.11 AMD20139.1 - 0.13 12.5 0.0 10 6.3 0.0 2.2 2 0 0 2 2 2 0 EF hand Polyketide_cyc PF03364.20 AMD20140.1 - 9.4e-16 58.2 0.0 1.3e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 AMD20140.1 - 0.0029 17.9 0.0 0.0036 17.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SAP PF02037.27 AMD20141.1 - 3.2e-11 42.7 0.3 5.9e-11 41.9 0.3 1.5 1 0 0 1 1 1 1 SAP domain Telomere_Sde2_2 PF13297.6 AMD20141.1 - 0.072 12.8 0.2 0.16 11.6 0.2 1.6 1 0 0 1 1 1 0 Telomere stability C-terminal CHCH PF06747.13 AMD20142.1 - 4.1e-05 23.6 4.1 6.3e-05 23.0 4.1 1.3 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.9 AMD20142.1 - 5.8e-05 23.3 7.5 8.4e-05 22.7 7.5 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CX9C PF16860.5 AMD20142.1 - 0.002 18.1 3.2 0.0033 17.4 3.2 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, MTCP1 PF08991.10 AMD20142.1 - 0.14 12.4 2.8 0.24 11.6 2.8 1.3 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type PRR18 PF15671.5 AMD20142.1 - 1.2 9.0 12.7 1.5 8.6 12.7 1.1 1 0 0 1 1 1 0 Proline-rich protein family 18 Topoisom_I_N PF02919.15 AMD20144.1 - 4e-96 320.6 0.3 4e-96 320.6 0.3 3.0 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 AMD20144.1 - 8.9e-95 316.3 1.1 8.9e-95 316.3 1.1 2.2 2 1 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 AMD20144.1 - 4.1e-31 106.7 0.5 1.4e-30 105.0 0.5 2.0 1 0 0 1 1 1 1 C-terminal topoisomerase domain Pkinase PF00069.25 AMD20145.1 - 1.8e-74 250.4 0.0 3e-74 249.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20145.1 - 6.2e-39 133.8 0.0 9.4e-39 133.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 AMD20145.1 - 3.1e-28 97.8 0.5 2.9e-14 53.0 0.0 3.0 3 0 0 3 3 3 2 POLO box duplicated region Kinase-like PF14531.6 AMD20145.1 - 1.4e-10 41.0 0.0 6.8e-10 38.7 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 AMD20145.1 - 0.00098 18.5 0.1 0.0026 17.1 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_3 PF08239.11 AMD20145.1 - 0.0047 17.2 0.1 0.0084 16.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 AMD20145.1 - 0.032 13.2 0.1 0.073 12.0 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain RNA_pol_L_2 PF13656.6 AMD20146.1 - 6.8e-27 93.1 0.1 9.6e-27 92.6 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 AMD20146.1 - 1.5e-09 37.1 0.0 2.4e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Thymidylate_kin PF02223.17 AMD20146.1 - 0.044 13.5 0.0 0.051 13.2 0.0 1.1 1 0 0 1 1 1 0 Thymidylate kinase Sin3a_C PF16879.5 AMD20147.1 - 2.9e-78 263.5 9.2 1.4e-77 261.3 8.3 2.7 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.21 AMD20147.1 - 1.5e-47 159.5 11.1 3.3e-18 65.6 2.2 4.1 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 AMD20147.1 - 6.1e-43 144.9 0.6 2.3e-42 143.0 0.1 2.4 2 0 0 2 2 2 1 Sin3 family co-repressor PRD PF00874.20 AMD20147.1 - 0.066 13.5 1.1 1.4 9.3 0.3 3.4 2 0 0 2 2 2 0 PRD domain MAM PF00629.23 AMD20147.1 - 0.8 9.6 3.5 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 MAM domain, meprin/A5/mu Dna2 PF08696.11 AMD20147.1 - 1.1 9.1 8.0 3.5 7.4 0.3 3.9 4 1 0 4 4 4 0 DNA replication factor Dna2 DHHC PF01529.20 AMD20148.1 - 2e-29 102.4 11.0 2e-29 102.4 11.0 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase HlyIII PF03006.20 AMD20149.1 - 2.9e-52 177.6 20.9 3.5e-52 177.3 20.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related DNA_pol_A_exo1 PF01612.20 AMD20150.1 - 3.9e-45 153.7 0.4 6.8e-45 152.9 0.4 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 AMD20150.1 - 6.6e-18 65.2 6.3 1.6e-17 63.9 1.8 3.1 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 AMD20150.1 - 2.1e-10 40.4 0.0 9.1e-10 38.4 0.0 2.1 2 0 0 2 2 2 1 HRDC domain DUF1690 PF07956.11 AMD20150.1 - 0.021 15.2 0.1 0.099 13.1 0.1 2.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF4363 PF14276.6 AMD20150.1 - 0.084 13.0 6.2 0.051 13.7 1.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) ApoLp-III PF07464.11 AMD20150.1 - 0.11 12.6 3.2 0.56 10.3 0.7 2.7 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Cnd1 PF12717.7 AMD20150.1 - 0.3 11.1 2.8 0.27 11.2 0.5 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Baculo_PEP_C PF04513.12 AMD20150.1 - 0.44 10.6 13.9 2.4 8.2 7.3 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SOBP PF15279.6 AMD20150.1 - 0.49 10.9 12.0 0.033 14.8 2.0 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein Cyclin PF08613.11 AMD20151.1 - 1.7e-36 126.0 0.9 1.7e-36 126.0 0.9 2.2 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 AMD20151.1 - 0.00018 21.3 0.6 0.00032 20.4 0.0 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Ras PF00071.22 AMD20152.1 - 1.2e-57 194.0 0.2 1.4e-57 193.8 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD20152.1 - 5.9e-34 116.9 0.1 1.1e-33 116.0 0.1 1.4 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD20152.1 - 4.1e-15 55.7 0.0 4.7e-15 55.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD20152.1 - 6.1e-08 32.3 0.1 7.4e-08 32.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AMD20152.1 - 1.6e-06 27.8 0.3 8.7e-05 22.1 0.3 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AMD20152.1 - 2.1e-06 27.8 0.0 4.2e-06 26.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 AMD20152.1 - 7.5e-05 22.2 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AMD20152.1 - 0.00016 21.6 0.1 0.031 14.2 0.0 2.4 1 1 1 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 AMD20152.1 - 0.0029 17.4 0.3 0.053 13.3 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 AMD20152.1 - 0.0032 17.8 0.0 0.0064 16.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 AMD20152.1 - 0.0069 16.0 0.0 0.02 14.5 0.0 1.7 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 AMD20152.1 - 0.0072 16.3 0.1 0.026 14.4 0.0 1.9 2 0 0 2 2 2 1 NTPase AAA_16 PF13191.6 AMD20152.1 - 0.011 16.2 0.0 0.016 15.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 AMD20152.1 - 0.014 15.2 0.2 0.076 12.8 0.1 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 AMD20152.1 - 0.014 14.8 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 AMD20152.1 - 0.021 14.7 0.0 0.047 13.6 0.0 1.6 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 AMD20152.1 - 0.026 14.2 0.1 0.089 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AMD20152.1 - 0.03 13.9 0.1 0.044 13.3 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 AMD20152.1 - 0.032 13.5 0.1 0.35 10.1 0.0 2.1 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 AMD20152.1 - 0.091 12.9 0.0 0.13 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AMD20152.1 - 0.12 11.5 0.1 0.55 9.4 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 AMD20152.1 - 0.17 11.8 0.0 0.49 10.4 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Alg6_Alg8 PF03155.15 AMD20153.1 - 8.8e-142 473.5 30.3 1.1e-141 473.2 30.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family TPR_1 PF00515.28 AMD20154.1 - 2.3e-20 71.5 9.9 7.8e-08 31.8 0.6 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat SGTA_dimer PF16546.5 AMD20154.1 - 4.7e-19 67.9 4.9 1.2e-18 66.6 4.9 1.8 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_2 PF07719.17 AMD20154.1 - 4.1e-18 64.0 10.3 6.2e-07 29.1 0.1 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 AMD20154.1 - 2.4e-14 52.7 10.4 2.5e-05 23.9 1.0 3.4 1 1 2 3 3 3 3 TPR repeat TPR_12 PF13424.6 AMD20154.1 - 5.3e-09 36.3 1.3 0.0039 17.5 0.1 2.8 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 AMD20154.1 - 1.8e-08 34.9 0.7 4.8e-07 30.3 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 AMD20154.1 - 2.1e-08 34.0 1.6 0.00035 20.8 0.2 3.2 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 AMD20154.1 - 8e-07 28.8 19.4 0.0003 20.8 1.7 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20154.1 - 9.8e-07 29.2 2.1 0.00049 20.6 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 AMD20154.1 - 1.3e-06 28.7 0.1 0.85 10.6 0.0 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 AMD20154.1 - 2.9e-06 26.9 4.0 0.0055 16.5 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 AMD20154.1 - 3.6e-05 24.1 2.8 0.045 14.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat STI1 PF17830.1 AMD20154.1 - 4.5e-05 23.3 12.3 0.00024 21.0 8.4 3.0 3 0 0 3 3 2 1 STI1 domain TPR_7 PF13176.6 AMD20154.1 - 0.00092 19.1 1.3 4.1 7.7 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 AMD20154.1 - 0.002 18.6 0.9 0.023 15.1 0.1 2.2 1 1 0 2 2 2 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 AMD20154.1 - 0.0023 18.0 4.0 0.16 12.0 0.1 3.5 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 AMD20154.1 - 0.0038 17.4 0.0 0.42 10.8 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD20154.1 - 0.0047 17.1 2.9 0.02 15.1 2.9 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Soc PF16855.5 AMD20154.1 - 0.013 16.0 0.7 0.05 14.1 0.7 1.9 2 0 0 2 2 2 0 Small outer capsid protein TPR_20 PF14561.6 AMD20154.1 - 0.024 15.0 2.7 1.8 9.0 0.0 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 AMD20154.1 - 0.16 12.0 6.7 0.39 10.7 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Prosystemin PF07376.11 AMD20154.1 - 0.51 9.8 10.0 0.057 12.9 1.4 2.2 2 0 0 2 2 2 0 Prosystemin SMG1 PF15785.5 AMD20154.1 - 0.68 8.2 3.5 0.28 9.5 0.4 1.7 2 0 0 2 2 2 0 Serine/threonine-protein kinase smg-1 MIT PF04212.18 AMD20154.1 - 1.9 8.6 14.9 3.7 7.7 0.3 4.4 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain VPS9 PF02204.18 AMD20155.1 - 3.3e-19 69.0 0.1 1.3e-18 67.1 0.1 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 AMD20155.1 - 3.4e-05 24.0 1.2 0.001 19.4 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 AMD20155.1 - 0.00055 20.5 1.6 3 8.5 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Antigen_Bd37 PF11641.8 AMD20155.1 - 0.012 15.2 0.2 0.72 9.3 0.1 2.7 2 0 0 2 2 2 0 Glycosylphosphatidylinositol-anchored merozoite surface protein Ribo_biogen_C PF04034.13 AMD20156.1 - 8.9e-52 174.1 0.0 1.4e-51 173.5 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 AMD20156.1 - 9.4e-16 57.3 0.2 1.6e-15 56.6 0.2 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI ANXA2R PF15721.5 AMD20156.1 - 0.0086 16.6 0.2 0.013 16.0 0.2 1.2 1 0 0 1 1 1 1 Annexin-2 receptor ERM PF00769.19 AMD20156.1 - 0.029 14.2 10.0 0.045 13.5 10.0 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family EF-G-binding_N PF07299.11 AMD20156.1 - 0.052 14.1 0.2 0.1 13.1 0.2 1.4 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal DNA_ligase_A_M PF01068.21 AMD20157.1 - 3.3e-46 157.5 0.0 1.8e-45 155.1 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 AMD20157.1 - 8.8e-24 84.8 0.0 1.5e-23 84.0 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 AMD20157.1 - 2.1e-12 47.3 0.0 6.3e-06 26.5 0.0 2.8 2 1 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 AMD20157.1 - 6.3e-09 36.4 0.0 1.7e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 RNA ligase BRCT PF00533.26 AMD20157.1 - 0.0071 16.7 0.0 0.08 13.3 0.0 2.8 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.19 AMD20157.1 - 0.062 13.1 0.3 2.8 7.7 0.0 3.1 2 1 0 2 2 2 0 mRNA capping enzyme, catalytic domain NPR2 PF06218.11 AMD20158.1 - 3.3e-133 444.7 7.7 5.3e-133 444.0 7.7 1.3 1 0 0 1 1 1 1 Nitrogen permease regulator 2 Dsl1_C PF11989.8 AMD20158.1 - 0.053 13.2 1.9 0.36 10.5 0.2 2.3 2 0 0 2 2 2 0 Retrograde transport protein Dsl1 C terminal Kinesin PF00225.23 AMD20159.1 - 6.7e-97 324.4 5.5 6.7e-97 324.4 5.5 3.4 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 AMD20159.1 - 1.5e-20 73.6 0.0 1.5e-20 73.6 0.0 3.4 4 0 0 4 4 4 1 Microtubule binding ATG16 PF08614.11 AMD20159.1 - 0.00037 20.8 12.3 0.00037 20.8 12.3 2.8 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) Rx_N PF18052.1 AMD20159.1 - 0.29 11.4 7.6 1.3 9.4 4.7 3.2 2 0 0 2 2 2 0 Rx N-terminal domain DUF3450 PF11932.8 AMD20159.1 - 0.72 9.1 13.7 1.3 8.2 9.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 AMD20159.1 - 1.7 8.7 22.3 3 7.9 1.7 4.4 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein Fcf1 PF04900.12 AMD20160.1 - 4.7e-35 119.9 2.4 8.2e-35 119.2 2.4 1.4 1 0 0 1 1 1 1 Fcf1 Fungal_trans_2 PF11951.8 AMD20161.1 - 5.8e-12 45.1 1.5 8.4e-12 44.6 1.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD20161.1 - 5e-08 32.9 13.3 1e-07 32.0 13.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF917 PF06032.12 AMD20162.1 - 4.6e-100 334.9 0.0 7.5e-100 334.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 AMD20162.1 - 7.7e-33 113.7 2.4 3e-31 108.5 0.0 3.3 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 AMD20162.1 - 4.7e-28 98.3 5.9 6e-27 94.7 2.6 3.1 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase MutL PF13941.6 AMD20162.1 - 0.013 14.2 0.5 0.47 9.0 0.1 2.2 2 0 0 2 2 2 0 MutL protein BcrAD_BadFG PF01869.20 AMD20162.1 - 0.076 12.5 1.0 2.4 7.6 0.3 2.9 3 1 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family DUF1512 PF07431.12 AMD20162.1 - 0.091 11.7 2.6 0.28 10.1 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) RrnaAD PF00398.20 AMD20163.1 - 2.3e-70 236.7 0.0 2.7e-70 236.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 AMD20163.1 - 1.9e-07 31.7 0.0 1.2e-06 29.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD20163.1 - 4.4e-05 24.1 0.0 0.00022 21.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 AMD20163.1 - 8.3e-05 22.4 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 AMD20163.1 - 0.0014 18.0 0.0 0.0062 15.9 0.0 1.8 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 AMD20163.1 - 0.0021 18.8 0.0 0.011 16.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 AMD20163.1 - 0.0081 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 AMD20163.1 - 0.0083 15.4 0.0 0.021 14.2 0.0 1.5 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_23 PF13489.6 AMD20163.1 - 0.021 14.7 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 AMD20163.1 - 0.024 14.4 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_28 PF02636.17 AMD20163.1 - 0.034 13.8 0.2 0.13 11.9 0.0 2.0 2 1 1 3 3 3 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 AMD20163.1 - 0.063 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PRMT5 PF05185.16 AMD20163.1 - 0.078 12.8 0.1 0.45 10.3 0.0 2.0 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase Sipho_Gp157 PF05565.11 AMD20164.1 - 0.0042 17.1 0.9 0.007 16.4 0.9 1.3 1 0 0 1 1 1 1 Siphovirus Gp157 PI-PLC-X PF00388.19 AMD20165.1 - 8.5e-50 168.1 0.0 1.7e-49 167.1 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 AMD20165.1 - 9.6e-38 129.1 0.3 2.6e-37 127.7 0.3 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 AMD20165.1 - 6.7e-06 26.5 0.6 1.6e-05 25.3 0.6 1.7 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.32 AMD20165.1 - 0.00092 18.6 0.5 0.0066 15.9 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 AMD20165.1 - 0.0039 17.6 1.1 0.037 14.5 0.3 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_10 PF14788.6 AMD20165.1 - 0.013 15.3 0.6 0.013 15.3 0.6 2.3 2 0 0 2 2 2 0 EF hand C2 PF00168.30 AMD20165.1 - 0.017 15.4 0.0 0.052 13.8 0.0 1.8 2 0 0 2 2 2 0 C2 domain EF-hand_6 PF13405.6 AMD20165.1 - 0.64 10.1 3.6 0.67 10.0 0.2 2.8 3 0 0 3 3 3 0 EF-hand domain KAR9 PF08580.10 AMD20166.1 - 2.6e-68 231.2 13.5 3.6e-68 230.7 13.5 1.1 1 0 0 1 1 1 1 Yeast cortical protein KAR9 DUF1539 PF07560.11 AMD20166.1 - 0.001 19.2 5.3 0.0031 17.6 1.5 3.1 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1539) Octopine_DH PF02317.17 AMD20166.1 - 0.052 13.6 0.0 0.18 11.9 0.0 2.0 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain GldM_N PF12081.8 AMD20166.1 - 0.53 10.4 4.1 0.36 10.9 0.9 2.3 2 0 0 2 2 2 0 GldM N-terminal domain ATP-synt_Eps PF04627.13 AMD20167.1 - 1.5e-16 60.1 1.2 1.8e-16 59.8 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain DNA_pol_phi PF04931.13 AMD20168.1 - 4.3e-194 646.8 46.6 1.8e-193 644.7 46.6 1.8 1 1 0 1 1 1 1 DNA polymerase phi UME PF08064.13 AMD20168.1 - 0.037 13.9 5.1 0.79 9.7 0.4 3.9 3 2 1 5 5 5 0 UME (NUC010) domain Herpes_LMP1 PF05297.11 AMD20168.1 - 0.22 10.7 4.3 0.34 10.1 4.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Serglycin PF04360.12 AMD20168.1 - 0.28 11.1 2.2 0.6 10.0 2.2 1.5 1 0 0 1 1 1 0 Serglycin BUD22 PF09073.10 AMD20168.1 - 1.3 8.3 14.8 1.1 8.5 12.3 2.2 2 0 0 2 2 2 0 BUD22 AF-4 PF05110.13 AMD20168.1 - 5.7 4.9 11.2 8.7 4.3 11.2 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CAF1C_H4-bd PF12265.8 AMD20170.1 - 8.9e-23 80.3 2.3 1.5e-22 79.6 0.6 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AMD20170.1 - 3.1e-15 56.3 2.4 0.00081 20.2 0.3 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20170.1 - 0.00096 19.4 0.2 0.34 11.2 0.0 3.9 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Kelch_4 PF13418.6 AMD20171.1 - 1.1e-32 111.8 5.8 7.5e-07 29.1 0.1 6.8 5 2 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 AMD20171.1 - 7e-28 96.3 3.8 2e-08 34.3 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain DUF4110 PF13422.6 AMD20171.1 - 8.9e-26 89.8 0.2 8.9e-26 89.8 0.2 3.4 4 1 1 5 5 5 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.6 AMD20171.1 - 5e-16 58.3 11.7 0.00037 20.7 0.1 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 AMD20171.1 - 2.8e-15 55.6 12.2 0.0056 16.6 0.0 6.7 6 1 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 AMD20171.1 - 3.6e-13 48.9 9.2 0.00013 21.5 0.1 6.4 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 AMD20171.1 - 9.6e-11 41.4 10.5 0.018 15.0 0.2 6.5 6 1 0 6 6 6 3 Kelch motif PGM_PMM_I PF02878.16 AMD20172.1 - 1.9e-16 60.1 0.0 1.2e-08 34.8 0.0 2.6 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 AMD20172.1 - 2.4e-10 40.4 0.1 5.9e-10 39.2 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 AMD20172.1 - 0.00097 19.7 0.1 0.042 14.5 0.1 3.0 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II CinA_KH PF18146.1 AMD20172.1 - 0.0025 17.9 0.5 0.01 15.9 0.1 2.2 2 0 0 2 2 2 1 Damage-inducible protein CinA KH domain EZH2_WD-Binding PF11616.8 AMD20172.1 - 0.19 11.9 0.4 14 5.9 0.1 2.7 2 0 0 2 2 2 0 WD repeat binding protein EZH2 Mitochondr_Som1 PF11093.8 AMD20173.1 - 1.4e-13 50.6 3.7 1.1e-12 47.7 3.7 1.9 1 1 0 1 1 1 1 Mitochondrial export protein Som1 Lyase_1 PF00206.20 AMD20174.1 - 1.3e-115 386.1 0.0 1.7e-115 385.7 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 AMD20174.1 - 8.2e-26 90.2 0.0 2.6e-25 88.6 0.0 1.9 2 0 0 2 2 2 1 Fumarase C C-terminus Peptidase_S8 PF00082.22 AMD20175.1 - 4.6e-32 111.5 11.7 2e-31 109.4 11.7 1.9 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 AMD20175.1 - 7.8e-10 39.3 0.1 1.7e-09 38.2 0.1 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 SUI1 PF01253.22 AMD20176.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AMD20176.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Homeodomain PF00046.29 AMD20177.1 - 1.5e-15 56.8 2.0 1.8e-15 56.5 2.0 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AMD20177.1 - 6.7e-06 25.9 0.3 6.7e-06 25.9 0.3 2.0 2 1 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 AMD20177.1 - 0.033 14.1 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT CRC_subunit PF08624.10 AMD20180.1 - 1.5e-39 135.5 0.1 2.8e-39 134.6 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Lectin_leg-like PF03388.13 AMD20181.1 - 7.2e-37 126.9 0.1 1.1e-36 126.3 0.1 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 AMD20181.1 - 0.00082 19.5 0.2 0.0014 18.6 0.2 1.4 1 0 0 1 1 1 1 Bacterial lectin DUF615 PF04751.14 AMD20181.1 - 0.082 12.9 0.9 0.14 12.1 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Phage_G PF02306.15 AMD20181.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Major spike protein (G protein) TMF_DNA_bd PF12329.8 AMD20181.1 - 1.1 9.4 5.0 0.58 10.2 0.3 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Rdx PF10262.9 AMD20182.1 - 1.3e-24 86.1 0.0 1.8e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Rdx family DEP PF00610.21 AMD20183.1 - 1.2e-12 47.7 0.2 2.7e-12 46.6 0.2 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.27 AMD20183.1 - 1.2e-08 34.9 0.4 1.2e-08 34.9 0.4 2.4 3 0 0 3 3 3 1 RhoGAP domain FCH PF00611.23 AMD20183.1 - 1.4e-08 34.9 2.9 1.2e-07 31.9 0.0 3.2 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF2951 PF11166.8 AMD20183.1 - 0.018 15.3 4.2 0.085 13.1 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Phage_tail_3 PF08813.11 AMD20184.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Phage tail tube protein, TTP V-SNARE_C PF12352.8 AMD20185.1 - 2e-06 28.0 4.3 2e-06 28.0 4.3 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 AMD20185.1 - 0.0008 19.3 0.5 0.0008 19.3 0.5 1.8 2 0 0 2 2 2 1 Sec20 FlgN PF05130.12 AMD20185.1 - 0.044 14.3 2.8 0.86 10.1 0.2 2.2 2 0 0 2 2 2 0 FlgN protein SOAR PF16533.5 AMD20185.1 - 0.075 13.0 1.5 1 9.4 0.1 2.4 2 1 0 2 2 2 0 STIM1 Orai1-activating region Syntaxin-6_N PF09177.11 AMD20185.1 - 0.24 12.0 3.7 2.5 8.7 3.7 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Spc7 PF08317.11 AMD20185.1 - 0.31 9.9 6.9 0.32 9.8 1.6 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 AMD20185.1 - 0.56 10.7 5.5 11 6.5 0.9 2.3 2 0 0 2 2 2 0 Snapin/Pallidin KxDL PF10241.9 AMD20185.1 - 2.3 8.6 6.1 2.2 8.6 0.8 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein RCC1 PF00415.18 AMD20186.1 - 6.2e-22 78.0 6.4 7.8e-07 29.6 0.0 6.5 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AMD20186.1 - 6e-20 70.5 11.4 9.1e-12 44.5 0.2 4.8 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat DUF1640 PF07798.11 AMD20187.1 - 3.9e-50 170.3 8.7 4.5e-50 170.1 8.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Fib_alpha PF08702.10 AMD20187.1 - 0.0079 16.4 9.2 0.037 14.2 3.3 2.1 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family Phage_Mu_Gam PF07352.12 AMD20187.1 - 0.12 12.3 7.2 1.3 8.9 0.7 2.4 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein IMD PF08397.11 AMD20187.1 - 0.13 11.6 5.8 0.17 11.3 5.8 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain Fungal_TACC PF12709.7 AMD20187.1 - 0.14 12.6 9.0 1.5 9.3 0.7 2.8 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins OspE PF02471.17 AMD20187.1 - 0.15 12.3 1.0 0.47 10.7 0.2 2.2 2 1 0 2 2 2 0 Borrelia outer surface protein E Arg_decarbox_C PF17944.1 AMD20187.1 - 0.17 12.5 1.8 8.4 7.0 0.0 3.6 3 1 1 4 4 4 0 Arginine decarboxylase C-terminal helical extension Spc7 PF08317.11 AMD20187.1 - 0.23 10.3 12.2 0.37 9.6 12.2 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 AMD20187.1 - 0.25 10.7 5.9 0.37 10.1 5.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COG2 PF06148.11 AMD20187.1 - 0.26 11.4 7.4 0.24 11.5 2.2 2.5 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF2756 PF10956.8 AMD20187.1 - 0.48 11.0 5.3 1.4 9.5 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2756) FlaC_arch PF05377.11 AMD20187.1 - 0.6 10.5 4.1 4.7 7.7 0.3 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Sulfatase_C PF14707.6 AMD20187.1 - 0.62 10.8 2.3 24 5.7 1.8 2.8 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase Uso1_p115_C PF04871.13 AMD20187.1 - 0.91 9.9 9.1 0.4 11.1 3.9 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region NPV_P10 PF05531.12 AMD20187.1 - 1.1 9.8 6.4 6.4 7.3 0.5 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 AMD20187.1 - 1.2 9.2 7.4 12 5.9 7.3 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TolA_bind_tri PF16331.5 AMD20187.1 - 1.3 9.1 10.3 3.8 7.7 2.8 2.6 2 1 0 2 2 2 0 TolA binding protein trimerisation DUF4200 PF13863.6 AMD20187.1 - 1.7 9.1 12.1 5.7 7.4 11.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4349 PF14257.6 AMD20187.1 - 1.8 8.0 9.3 16 4.8 9.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4349) DUF5339 PF17274.2 AMD20187.1 - 3.2 8.7 6.2 17 6.3 1.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5339) XhlA PF10779.9 AMD20187.1 - 5 7.4 9.8 0.4 10.9 1.8 2.8 2 2 0 2 2 2 0 Haemolysin XhlA Atg14 PF10186.9 AMD20187.1 - 7.2 5.6 12.0 13 4.8 11.9 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PMM PF03332.13 AMD20188.1 - 2e-112 374.3 0.7 2.3e-112 374.1 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 AMD20188.1 - 7.1e-07 29.2 0.0 2.6e-06 27.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AMD20188.1 - 0.00066 19.3 0.0 0.35 10.4 0.0 2.0 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 AMD20188.1 - 0.066 13.5 0.2 0.23 11.7 0.2 1.9 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DDE_Tnp_4 PF13359.6 AMD20188.1 - 0.14 11.9 0.3 1.4 8.6 0.2 2.4 2 1 0 2 2 2 0 DDE superfamily endonuclease RHH_1 PF01402.21 AMD20188.1 - 0.19 11.7 0.5 3.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family Ribosomal_L16 PF00252.18 AMD20189.1 - 1.9e-41 141.1 0.1 2.4e-41 140.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e zf-C2H2_jaz PF12171.8 AMD20190.1 - 5e-10 39.4 5.5 5.8e-10 39.2 3.1 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AMD20190.1 - 0.0011 19.3 0.5 0.0026 18.0 0.1 1.8 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 AMD20190.1 - 0.012 16.0 3.1 0.075 13.4 2.5 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-U1 PF06220.12 AMD20190.1 - 0.092 12.5 1.6 0.19 11.5 1.6 1.5 1 0 0 1 1 1 0 U1 zinc finger zf-C2HE PF16278.5 AMD20190.1 - 0.37 11.3 6.7 4.5 7.8 2.1 3.1 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger OTU PF02338.19 AMD20191.1 - 5.2e-08 33.4 0.0 9.4e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease BIR PF00653.21 AMD20191.1 - 0.12 13.0 0.0 0.49 11.1 0.0 1.9 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain USP8_dimer PF08969.11 AMD20192.1 - 2.5e-09 37.3 0.4 5.8e-09 36.2 0.4 1.7 1 1 0 1 1 1 1 USP8 dimerisation domain DUF3584 PF12128.8 AMD20192.1 - 0.038 11.5 0.1 0.042 11.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) VASt PF16016.5 AMD20193.1 - 1.1e-35 123.3 1.2 2e-35 122.4 0.2 2.1 3 0 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 AMD20193.1 - 8.6e-25 86.8 0.2 2.2e-24 85.5 0.2 1.7 1 0 0 1 1 1 1 GRAM domain EssA PF10661.9 AMD20193.1 - 0.058 13.2 0.2 0.16 11.8 0.2 1.7 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA Med14 PF08638.11 AMD20194.1 - 1e-53 181.6 1.2 1.4e-53 181.2 0.1 1.8 2 0 0 2 2 2 1 Mediator complex subunit MED14 ADH_N PF08240.12 AMD20195.1 - 3.2e-29 101.0 0.8 1.6e-28 98.7 0.0 2.3 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AMD20195.1 - 2.6e-27 95.3 0.1 5.1e-27 94.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AMD20195.1 - 1e-11 44.7 0.2 2.1e-11 43.7 0.2 1.5 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 AMD20195.1 - 8.1e-05 23.7 0.0 0.00027 22.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 AMD20195.1 - 0.0026 17.1 0.8 0.0046 16.3 0.8 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 AMD20195.1 - 0.037 13.2 0.3 0.43 9.8 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PALP PF00291.25 AMD20195.1 - 0.076 12.4 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme 2-Hacid_dh_C PF02826.19 AMD20195.1 - 0.12 11.8 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 AMD20195.1 - 0.13 12.8 1.0 1.7 9.2 0.5 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Cu-oxidase_2 PF07731.14 AMD20196.1 - 2.8e-45 153.4 5.6 1.6e-37 128.3 0.1 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AMD20196.1 - 1e-38 132.0 6.2 3.9e-38 130.1 1.2 3.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 AMD20196.1 - 1.3e-38 132.7 6.4 7.6e-33 113.9 1.1 3.4 3 0 0 3 3 3 3 Multicopper oxidase GTP_EFTU PF00009.27 AMD20197.1 - 7.5e-63 211.6 0.6 2.1e-62 210.1 0.2 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AMD20197.1 - 3.1e-34 117.4 0.1 6.6e-34 116.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 AMD20197.1 - 6.4e-32 109.5 0.0 1.6e-31 108.2 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 AMD20197.1 - 3e-23 81.6 0.0 1.6e-22 79.3 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AMD20197.1 - 5.9e-12 45.8 0.8 1.8e-11 44.3 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 AMD20197.1 - 1.4e-06 28.1 0.0 3.5e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 AMD20197.1 - 0.019 15.1 0.0 0.059 13.5 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase AvrPtoB_bdg PF16847.5 AMD20197.1 - 0.045 14.2 0.0 0.73 10.4 0.0 2.5 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain rRNA_processing PF08524.11 AMD20198.1 - 1.4e-30 106.3 40.7 2.1e-30 105.7 40.7 1.2 1 1 0 1 1 1 1 rRNA processing Suf PF05843.14 AMD20198.1 - 0.22 11.4 9.5 0.27 11.2 9.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) hDGE_amylase PF14701.6 AMD20198.1 - 1.2 8.2 8.1 1.3 8.1 8.1 1.0 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain PPR_2 PF13041.6 AMD20199.1 - 9.8e-09 35.3 9.0 0.4 10.9 0.0 7.2 3 1 3 7 7 7 4 PPR repeat family PPR PF01535.20 AMD20199.1 - 2.1e-06 27.6 18.5 2.6 8.5 0.0 8.0 7 0 0 7 7 7 3 PPR repeat PPR_long PF17177.4 AMD20199.1 - 2.3e-06 27.1 0.7 0.00013 21.4 0.1 2.7 1 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 AMD20199.1 - 0.012 15.7 6.4 0.14 12.2 0.4 3.8 4 1 1 5 5 5 0 Pentatricopeptide repeat domain SPC22 PF04573.12 AMD20200.1 - 1.2e-54 184.3 1.9 1.4e-54 184.1 1.9 1.0 1 0 0 1 1 1 1 Signal peptidase subunit Sugar_tr PF00083.24 AMD20201.1 - 3.9e-67 227.1 37.6 5.3e-67 226.6 37.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD20201.1 - 1.4e-16 60.4 42.2 2.8e-16 59.4 23.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Actin PF00022.19 AMD20202.1 - 6e-150 499.4 0.0 1.9e-149 497.7 0.0 1.6 1 1 0 1 1 1 1 Actin TMEM208_SND2 PF05620.11 AMD20203.1 - 1e-36 126.3 3.7 1.2e-36 126.1 3.7 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Wzy_C_2 PF11846.8 AMD20203.1 - 0.34 10.8 0.0 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Ras PF00071.22 AMD20204.1 - 4.3e-63 211.7 0.5 5.1e-63 211.5 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD20204.1 - 1.3e-36 125.4 0.2 2.2e-36 124.7 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD20204.1 - 3.8e-18 65.5 0.2 5e-18 65.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD20204.1 - 4e-06 26.4 0.2 5.9e-06 25.8 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AMD20204.1 - 0.0001 21.9 0.5 0.00038 20.0 0.2 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AMD20204.1 - 0.00016 21.8 0.1 0.00024 21.1 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 AMD20204.1 - 0.00021 20.7 0.2 0.00028 20.4 0.2 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AMD20204.1 - 0.00056 19.9 0.3 0.13 12.1 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase AAA PF00004.29 AMD20204.1 - 0.0097 16.3 0.0 0.21 12.0 0.0 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AMD20204.1 - 0.026 14.9 0.0 0.036 14.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 AMD20204.1 - 0.026 13.8 0.1 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 Septin AAA_29 PF13555.6 AMD20204.1 - 0.043 13.6 0.4 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain CENP-M PF11111.8 AMD20204.1 - 0.066 12.4 0.0 0.093 11.9 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_22 PF13401.6 AMD20204.1 - 0.073 13.4 0.0 0.11 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AMD20204.1 - 0.09 13.3 0.1 0.15 12.6 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 AMD20204.1 - 0.091 12.8 0.0 0.15 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 AMD20204.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein UPF0121 PF03661.13 AMD20205.1 - 1.4e-14 54.1 18.9 2e-14 53.6 18.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Tubulin PF00091.25 AMD20206.1 - 5.2e-68 229.1 0.0 8.8e-68 228.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AMD20206.1 - 5.7e-43 146.1 0.0 1e-42 145.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 AMD20206.1 - 0.0021 17.7 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 AMD20206.1 - 0.0048 16.1 0.0 0.0095 15.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 AMD20206.1 - 0.014 15.7 0.0 0.037 14.3 0.0 1.8 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain RNA_pol PF00940.19 AMD20207.1 - 6.6e-173 575.3 0.0 1.2e-172 574.5 0.0 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 AMD20207.1 - 2.1e-103 346.2 0.4 3.1e-103 345.7 0.4 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal DrrA_P4M PF14860.6 AMD20207.1 - 0.019 14.8 1.1 0.062 13.1 1.1 1.9 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain DUF4441 PF14536.6 AMD20207.1 - 5.2 7.3 8.4 0.88 9.8 1.4 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) Mob1_phocein PF03637.17 AMD20208.1 - 3.8e-63 212.5 0.7 5.2e-63 212.1 0.7 1.2 1 0 0 1 1 1 1 Mob1/phocein family NCOA_u2 PF16665.5 AMD20208.1 - 0.061 13.6 1.6 0.098 13.0 1.6 1.2 1 0 0 1 1 1 0 Unstructured region on nuclear receptor coactivator protein Methyltransf_34 PF11312.8 AMD20209.1 - 1.2e-87 294.1 0.4 1.5e-87 293.7 0.4 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Ribosomal_L22e PF01776.17 AMD20210.1 - 7.3e-40 135.7 1.1 7.3e-40 135.7 1.1 1.3 2 0 0 2 2 2 1 Ribosomal L22e protein family DUF726 PF05277.12 AMD20211.1 - 1.5e-128 428.5 1.3 3e-128 427.6 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF726) tRNA_synthFbeta PF17759.1 AMD20212.1 - 3.5e-39 134.5 0.0 5.8e-39 133.8 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 AMD20212.1 - 2.1e-30 105.7 0.0 3.4e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain PhetRS_B1 PF18262.1 AMD20212.1 - 1.4e-29 102.2 1.9 2.6e-29 101.3 0.5 2.2 2 1 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 AMD20212.1 - 1e-20 73.8 0.0 7.1e-18 64.7 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain tRNA-synt_2d PF01409.20 AMD20212.1 - 0.027 13.9 0.0 0.31 10.5 0.0 2.2 1 1 0 1 1 1 0 tRNA synthetases class II core domain (F) Pkinase PF00069.25 AMD20213.1 - 3.1e-58 197.2 9.3 2e-37 129.0 0.7 3.1 3 0 0 3 3 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20213.1 - 6e-25 88.0 4.8 8e-21 74.5 0.1 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Response_reg PF00072.24 AMD20213.1 - 1.3e-06 28.5 0.0 3.9e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain Kdo PF06293.14 AMD20213.1 - 1.3e-05 24.7 0.0 3.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AMD20213.1 - 9.9e-05 21.8 5.8 0.0076 15.6 0.0 3.0 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 AMD20213.1 - 0.00021 21.3 0.1 0.065 13.1 0.2 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 AMD20213.1 - 0.0043 16.7 1.2 0.025 14.2 0.1 2.3 1 1 1 2 2 2 1 RIO1 family PAS_9 PF13426.7 AMD20213.1 - 0.011 16.0 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 0 PAS domain PAS PF00989.25 AMD20213.1 - 0.02 14.9 0.0 0.02 14.9 0.0 2.4 2 0 0 2 2 2 0 PAS fold Seadorna_VP7 PF07387.11 AMD20213.1 - 0.022 13.8 0.1 0.042 12.9 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 PAS_4 PF08448.10 AMD20213.1 - 0.068 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 PAS fold RR_TM4-6 PF06459.12 AMD20213.1 - 0.44 10.3 5.3 1.2 8.8 5.3 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 AMD20213.1 - 1 8.2 11.1 2 7.3 11.1 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 AMD20213.1 - 1.5 8.7 46.1 0.29 11.1 25.5 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 AMD20213.1 - 3.8 7.0 36.3 0.18 11.4 29.2 2.3 2 0 0 2 2 2 0 Spt20 family Tim54 PF11711.8 AMD20213.1 - 5.6 5.7 8.8 11 4.7 8.8 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNase_T PF00929.24 AMD20214.1 - 1.5e-35 123.2 0.1 1.8e-35 122.9 0.1 1.1 1 0 0 1 1 1 1 Exonuclease DUF4286 PF14114.6 AMD20214.1 - 0.046 14.2 0.6 17 6.0 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4286) bZIP_2 PF07716.15 AMD20215.1 - 0.00012 22.1 7.3 0.00012 22.1 7.3 1.8 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 AMD20215.1 - 0.00014 21.9 7.0 0.00023 21.2 7.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor SHMT PF00464.19 AMD20216.1 - 7.1e-207 686.7 0.0 8.3e-207 686.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 AMD20216.1 - 9.2e-06 25.1 0.0 1.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AMD20216.1 - 4.9e-05 22.5 0.0 7.2e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AMD20216.1 - 0.002 17.5 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AMD20216.1 - 0.031 13.6 0.2 0.16 11.3 0.2 1.9 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 AMD20216.1 - 0.13 10.8 0.0 0.21 10.1 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Glyco_hydro_47 PF01532.20 AMD20217.1 - 3.1e-86 290.1 0.1 3.8e-86 289.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Pkinase PF00069.25 AMD20219.1 - 8.7e-37 126.9 0.0 3.9e-36 124.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20219.1 - 2.2e-22 79.6 0.0 3e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AMD20219.1 - 8.6e-06 25.8 0.0 1.9e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 AMD20219.1 - 8.5e-05 22.0 0.1 0.0002 20.8 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AMD20219.1 - 0.0012 18.5 0.2 0.023 14.3 0.1 2.1 1 1 0 2 2 2 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 AMD20219.1 - 0.0026 16.6 0.1 0.0032 16.3 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 AMD20219.1 - 0.012 14.6 0.4 0.018 14.0 0.4 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 AMD20219.1 - 0.015 14.9 0.1 0.026 14.1 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Laminin_N PF00055.17 AMD20219.1 - 0.097 12.3 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Laminin N-terminal (Domain VI) ABC_tran PF00005.27 AMD20220.1 - 1.2e-17 64.7 0.0 7.1e-17 62.2 0.0 2.0 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AMD20220.1 - 1.1e-10 41.8 0.9 2.3e-05 24.4 0.2 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AMD20220.1 - 7.3e-06 25.6 0.4 0.00015 21.2 0.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 AMD20220.1 - 0.0014 18.5 0.0 0.0022 17.9 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 AMD20220.1 - 0.0017 18.0 0.1 0.0033 17.1 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Sigma54_activat PF00158.26 AMD20220.1 - 0.0024 17.6 0.1 0.47 10.2 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_23 PF13476.6 AMD20220.1 - 0.0049 17.4 0.0 0.0076 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AMD20220.1 - 0.011 15.5 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 AMD20220.1 - 0.02 14.2 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 AMD20220.1 - 0.027 14.2 0.4 2.2 8.0 0.0 2.1 1 1 1 2 2 2 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 AMD20220.1 - 0.027 14.5 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 AMD20220.1 - 0.036 14.3 0.5 0.18 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AMD20220.1 - 0.046 14.1 0.0 0.068 13.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 AMD20220.1 - 0.049 13.8 0.0 0.077 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 AMD20220.1 - 0.056 12.8 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Rad17 PF03215.15 AMD20220.1 - 0.062 13.2 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain DUF3584 PF12128.8 AMD20220.1 - 0.083 10.4 0.0 0.11 10.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_18 PF13238.6 AMD20220.1 - 0.09 13.3 0.4 0.13 12.8 0.4 1.5 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 AMD20220.1 - 0.16 12.0 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Dynamin family WD40 PF00400.32 AMD20221.1 - 4e-09 37.0 3.8 0.6 11.1 0.2 7.1 8 0 0 8 8 8 2 WD domain, G-beta repeat Frtz PF11768.8 AMD20221.1 - 0.12 10.7 0.0 2.4 6.4 0.0 2.3 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz M60-like_N PF17291.2 AMD20222.1 - 0.059 13.3 0.0 0.097 12.6 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of M60-like peptidases Cation_efflux PF01545.21 AMD20223.1 - 2.7e-56 190.5 2.4 3.5e-56 190.1 2.4 1.1 1 0 0 1 1 1 1 Cation efflux family SPX PF03105.19 AMD20223.1 - 0.031 14.2 0.7 0.045 13.7 0.7 1.1 1 0 0 1 1 1 0 SPX domain COX6B PF02297.17 AMD20224.1 - 6e-23 80.9 6.2 8.3e-23 80.4 6.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Prolamin_like PF05617.11 AMD20224.1 - 0.041 14.1 2.2 0.058 13.6 2.2 1.2 1 0 0 1 1 1 0 Prolamin-like RabGAP-TBC PF00566.18 AMD20225.1 - 1.1e-13 51.4 1.6 2e-13 50.5 1.6 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_L18A PF01775.17 AMD20227.1 - 1.2e-53 180.4 0.6 1.6e-53 180.0 0.6 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A CTP_transf_1 PF01148.20 AMD20228.1 - 0.00054 19.8 6.0 0.00086 19.1 6.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase family Nop PF01798.18 AMD20229.1 - 9.2e-82 273.9 0.3 9.2e-82 273.9 0.3 2.4 3 0 0 3 3 3 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 AMD20229.1 - 2e-20 72.9 3.0 2e-20 72.9 3.0 2.7 2 1 0 2 2 2 1 NOP5NT (NUC127) domain DUF4604 PF15377.6 AMD20229.1 - 0.064 13.7 49.2 0.14 12.6 49.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) SART-1 PF03343.13 AMD20230.1 - 2.2e-51 175.2 55.5 5.6e-50 170.6 55.5 2.9 1 1 0 1 1 1 1 SART-1 family TPT PF03151.16 AMD20231.1 - 2.8e-35 122.1 24.2 2.5e-19 69.7 7.5 3.0 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 AMD20231.1 - 2.5e-06 27.7 31.2 0.0073 16.5 9.0 3.8 3 1 0 3 3 3 2 EamA-like transporter family TMEM100 PF16311.5 AMD20231.1 - 0.67 9.6 2.3 4.2 7.0 0.3 2.5 2 0 0 2 2 2 0 Transmembrane protein 100 Mito_carr PF00153.27 AMD20232.1 - 9.9e-29 99.1 4.8 2.2e-12 46.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2034 PF10356.9 AMD20233.1 - 2.4e-51 173.8 0.0 2.9e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 AMD20233.1 - 0.0021 18.1 0.0 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 Restriction endonuclease Mrr_cat_2 PF13156.6 AMD20233.1 - 0.12 12.2 0.2 0.46 10.4 0.1 1.8 2 0 0 2 2 2 0 Restriction endonuclease T6PP_N PF18572.1 AMD20234.1 - 0.017 14.9 0.8 0.024 14.5 0.8 1.2 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain TRAF_BIRC3_bd PF16673.5 AMD20234.1 - 0.088 12.6 2.5 0.11 12.2 2.5 1.2 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DUF382 PF04037.13 AMD20235.1 - 6.5e-50 168.5 0.0 1.3e-49 167.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 AMD20235.1 - 7.4e-18 64.2 1.5 1.4e-17 63.2 1.5 1.5 1 0 0 1 1 1 1 PSP RNase_3_N PF18497.1 AMD20236.1 - 4e-38 129.9 0.5 8e-38 128.9 0.5 1.5 1 0 0 1 1 1 1 Ribonuclease III N-terminal domain Ribonuclease_3 PF00636.26 AMD20236.1 - 6.4e-16 58.9 0.0 1.8e-15 57.4 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 AMD20236.1 - 1.2e-12 48.1 0.0 2.2e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 AMD20236.1 - 0.0018 19.0 0.0 0.0061 17.2 0.0 2.0 2 0 0 2 2 2 1 Double-stranded RNA binding motif SNF2_N PF00176.23 AMD20237.1 - 5e-75 252.4 0.3 9.1e-75 251.5 0.3 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 AMD20237.1 - 1.4e-36 125.0 2.1 1.4e-36 125.0 2.1 3.2 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 AMD20237.1 - 4.8e-32 111.0 0.7 4.8e-32 111.0 0.7 2.5 2 0 0 2 2 2 1 HAND Helicase_C PF00271.31 AMD20237.1 - 7.3e-19 68.2 0.1 3.5e-18 65.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD20237.1 - 4.4e-13 49.6 0.4 4e-12 46.5 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AMD20237.1 - 2.6e-05 24.1 0.0 0.00012 21.9 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 AMD20237.1 - 4.3e-05 23.3 0.0 0.00014 21.6 0.0 1.9 2 0 0 2 2 2 1 SWI2/SNF2 ATPase Myb_DNA-binding PF00249.31 AMD20237.1 - 6.1e-05 23.1 0.0 0.0021 18.2 0.0 3.3 3 0 0 3 3 2 1 Myb-like DNA-binding domain HDA2-3 PF11496.8 AMD20237.1 - 0.0017 17.6 2.1 0.0028 16.9 0.0 2.5 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 DEAD_2 PF06733.15 AMD20237.1 - 0.0063 16.2 0.7 0.019 14.6 0.0 2.1 2 0 0 2 2 2 1 DEAD_2 ERCC3_RAD25_C PF16203.5 AMD20237.1 - 0.0089 15.3 0.4 0.019 14.2 0.4 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 AMD20237.1 - 0.043 13.8 0.1 0.24 11.4 0.1 2.3 1 0 0 1 1 1 0 AAA domain DUF4116 PF13475.6 AMD20237.1 - 0.071 12.9 0.1 0.32 10.8 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) RCC1 PF00415.18 AMD20238.1 - 2.1e-11 44.2 0.5 1.6e-05 25.4 0.0 4.0 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AMD20238.1 - 4.1e-06 26.4 13.8 2.4e-05 24.0 1.6 3.7 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 AMD20238.1 - 0.0017 18.5 0.0 0.0057 16.9 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain Ank_4 PF13637.6 AMD20238.1 - 0.0099 16.4 0.3 0.049 14.2 0.0 2.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Mtd_N PF18454.1 AMD20238.1 - 0.068 13.2 0.1 0.22 11.6 0.1 1.9 1 0 0 1 1 1 0 Major tropism determinant N-terminal domain PRP3 PF08572.10 AMD20238.1 - 0.21 11.3 2.0 0.49 10.1 2.0 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) Draxin PF15550.6 AMD20238.1 - 5.2 6.8 6.0 0.37 10.6 1.0 1.5 2 0 0 2 2 2 0 Draxin RGS PF00615.19 AMD20240.1 - 0.026 14.8 0.9 0.23 11.7 0.0 2.5 1 1 1 2 2 2 0 Regulator of G protein signaling domain Glyco_hydro_76 PF03663.14 AMD20241.1 - 7.7e-142 473.1 2.4 9e-142 472.9 2.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AMD20241.1 - 0.023 13.8 4.9 2.2 7.2 0.0 3.0 2 1 0 2 2 2 0 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 AMD20242.1 - 1.9e-140 468.5 2.8 2.3e-140 468.3 2.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AMD20242.1 - 0.00018 20.7 4.5 0.24 10.4 0.1 3.1 2 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 Glyco_hydro_47 PF01532.20 AMD20242.1 - 0.069 12.0 0.1 1.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 47 ChAPs PF09295.10 AMD20243.1 - 3.6e-164 546.5 0.5 5.1e-164 546.0 0.5 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) HrpB1_HrpK PF09613.10 AMD20243.1 - 0.03 13.9 0.1 0.064 12.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_8 PF13181.6 AMD20243.1 - 0.11 12.7 0.0 12 6.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 AMD20243.1 - 0.81 10.0 2.5 6.2 7.2 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TFIID-31kDa PF02291.15 AMD20244.1 - 7.4e-49 164.9 0.0 9e-49 164.6 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit MBF1 PF08523.10 AMD20245.1 - 7.8e-21 74.3 0.3 1.6e-20 73.4 0.3 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 AMD20245.1 - 8.2e-15 54.6 0.2 1.6e-14 53.7 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 AMD20245.1 - 4.8e-06 26.8 0.0 1.1e-05 25.6 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 AMD20245.1 - 0.0008 19.4 0.2 0.0013 18.7 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain LRR_6 PF13516.6 AMD20246.1 - 2.5e-07 30.2 11.5 0.56 10.4 0.2 7.6 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 AMD20246.1 - 2.6e-07 30.2 0.7 42 5.3 0.0 7.3 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_4 PF12799.7 AMD20246.1 - 1.4e-06 28.5 17.5 0.52 10.8 0.7 6.8 4 2 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AMD20246.1 - 0.0014 18.4 14.1 3.3 7.5 0.0 6.0 4 2 1 5 5 5 3 Leucine rich repeat Bombinin PF05298.11 AMD20246.1 - 0.072 12.8 0.7 0.15 11.7 0.7 1.5 1 0 0 1 1 1 0 Bombinin Acyltransferase PF01553.21 AMD20247.1 - 7.6e-05 22.3 0.0 0.00024 20.8 0.0 1.8 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 AMD20247.1 - 0.035 14.2 0.1 0.089 12.9 0.1 1.6 1 0 0 1 1 1 0 Acyltransferase C-terminus RGS-like PF09128.11 AMD20247.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain CybS PF05328.12 AMD20248.1 - 1.8e-51 173.3 0.0 2.1e-51 173.1 0.0 1.0 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Sdh_cyt PF01127.22 AMD20248.1 - 0.084 12.9 2.4 0.87 9.6 2.4 2.0 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit STE2 PF02116.15 AMD20249.1 - 3.5e-79 266.0 19.9 4.2e-79 265.8 19.9 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR DUF347 PF03988.12 AMD20249.1 - 0.94 9.7 0.1 0.94 9.7 0.1 3.4 4 0 0 4 4 4 0 Repeat of Unknown Function (DUF347) PGAP1 PF07819.13 AMD20250.1 - 4.6e-96 321.0 0.1 7.4e-96 320.3 0.1 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 AMD20250.1 - 0.00027 20.9 0.0 0.00065 19.6 0.0 1.7 2 0 0 2 2 2 1 Palmitoyl protein thioesterase Abhydrolase_5 PF12695.7 AMD20250.1 - 0.016 15.0 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 AMD20250.1 - 0.02 15.5 0.0 0.034 14.7 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD20250.1 - 0.027 13.7 0.0 0.045 13.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF915 PF06028.11 AMD20250.1 - 0.032 13.6 0.1 0.19 11.0 0.1 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.20 AMD20250.1 - 0.043 13.4 0.0 0.098 12.3 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF676 PF05057.14 AMD20250.1 - 0.049 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Esterase PF00756.20 AMD20250.1 - 0.058 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.25 AMD20250.1 - 0.061 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) LCAT PF02450.15 AMD20250.1 - 0.11 11.6 1.0 0.16 11.1 0.1 1.5 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase DUF2974 PF11187.8 AMD20250.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) EPL1 PF10513.9 AMD20251.1 - 1.5e-22 80.6 2.9 1.5e-22 80.6 2.9 3.4 3 0 0 3 3 3 1 Enhancer of polycomb-like DUF3835 PF12927.7 AMD20252.1 - 4.7e-18 65.8 0.1 4.7e-18 65.8 0.1 6.4 8 1 1 9 9 9 2 Domain of unknown function (DUF3835) Prefoldin PF02996.17 AMD20252.1 - 1.4e-09 37.9 1.3 1.4e-09 37.9 1.3 2.9 3 0 0 3 3 3 1 Prefoldin subunit GCR1_C PF12550.8 AMD20253.1 - 1.9e-12 47.3 3.6 2.7e-11 43.6 3.6 2.4 1 1 0 1 1 1 1 Transcriptional activator of glycolytic enzymes EBP PF05241.12 AMD20253.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Emopamil binding protein Endosulfine PF04667.17 AMD20253.1 - 0.081 13.1 0.3 0.32 11.2 0.3 2.0 1 0 0 1 1 1 0 cAMP-regulated phosphoprotein/endosulfine conserved region Nop14 PF04147.12 AMD20254.1 - 5.4e-05 21.6 30.7 5.4e-05 21.6 30.7 2.1 2 0 0 2 2 2 1 Nop14-like family Drc1-Sld2 PF11719.8 AMD20254.1 - 0.66 9.5 31.0 0.019 14.5 17.2 2.4 2 0 0 2 2 2 0 DNA replication and checkpoint protein BUD22 PF09073.10 AMD20254.1 - 5.4 6.2 47.9 0.21 10.9 31.5 2.1 2 0 0 2 2 2 0 BUD22 tRNA-synt_2d PF01409.20 AMD20255.1 - 5.3e-91 304.4 0.0 7.6e-91 303.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 AMD20255.1 - 4.5e-13 49.3 0.6 2.6e-12 46.8 0.1 2.6 3 0 0 3 3 3 1 PheRS DNA binding domain 3 PheRS_DBD2 PF18554.1 AMD20255.1 - 3.6e-10 39.6 1.8 1.3e-09 37.9 1.8 2.1 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA_synthFbeta PF17759.1 AMD20255.1 - 1.6e-08 34.3 0.0 2.4e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 AMD20255.1 - 1.7e-05 24.1 0.1 0.0006 19.0 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 AMD20255.1 - 5.7e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) UDPG_MGDP_dh_N PF03721.14 AMD20255.1 - 0.048 13.2 0.1 0.083 12.4 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PaaX PF07848.12 AMD20255.1 - 0.064 13.5 0.0 3.2 8.1 0.0 2.8 3 0 0 3 3 3 0 PaaX-like protein Fcf2 PF08698.11 AMD20257.1 - 1.8e-35 121.2 0.5 3.7e-35 120.2 0.5 1.5 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing GATA PF00320.27 AMD20258.1 - 6.4e-15 54.5 6.6 1.3e-14 53.5 6.6 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 AMD20258.1 - 1.1e-08 34.7 0.6 2.7e-08 33.5 0.1 2.0 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) Mito_fiss_reg PF05308.11 AMD20258.1 - 0.011 15.9 5.5 0.017 15.2 5.5 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 AMD20258.1 - 0.015 15.4 8.1 0.029 14.4 6.4 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 AMD20258.1 - 0.023 14.2 8.3 0.036 13.6 8.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TMEM171 PF15471.6 AMD20258.1 - 0.087 11.8 2.4 0.13 11.2 2.4 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 VIR_N PF15912.5 AMD20258.1 - 0.14 11.7 2.5 0.21 11.1 2.5 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal TF_Zn_Ribbon PF08271.12 AMD20258.1 - 0.18 11.3 2.1 0.39 10.3 2.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Pyr_redox_2 PF07992.14 AMD20259.1 - 7.4e-70 235.5 5.2 1e-69 235.0 5.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AMD20259.1 - 2.9e-43 146.6 0.1 8.8e-43 145.1 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AMD20259.1 - 6.5e-21 74.7 9.5 1e-18 67.6 0.8 3.4 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AMD20259.1 - 4.3e-12 46.1 1.6 2e-05 24.7 0.2 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 AMD20259.1 - 7.7e-12 45.0 4.7 1.3e-10 41.0 1.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 AMD20259.1 - 3.1e-11 43.1 6.1 1.4e-07 31.1 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AMD20259.1 - 6.7e-11 42.2 5.7 2e-10 40.6 0.3 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AMD20259.1 - 4.7e-08 32.1 8.0 8.8e-05 21.4 0.1 4.1 3 1 1 4 4 4 2 HI0933-like protein FAD_binding_2 PF00890.24 AMD20259.1 - 2.5e-07 30.1 1.5 2.5e-07 30.1 1.5 2.5 2 1 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 AMD20259.1 - 2.7e-07 30.1 1.6 0.006 15.9 0.1 2.9 2 1 1 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 AMD20259.1 - 1.6e-06 27.6 10.0 0.0085 15.4 0.9 3.7 2 1 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 AMD20259.1 - 5.1e-06 25.9 1.6 0.0019 17.5 0.0 2.5 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 AMD20259.1 - 4.6e-05 23.2 16.1 0.29 10.7 1.6 4.2 3 1 1 4 4 4 3 FAD dependent oxidoreductase K_oxygenase PF13434.6 AMD20259.1 - 9.8e-05 21.6 0.9 0.88 8.6 0.1 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) THF_DHG_CYH_C PF02882.19 AMD20259.1 - 0.011 15.1 0.1 0.048 13.0 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Lycopene_cycl PF05834.12 AMD20259.1 - 0.041 12.9 4.0 0.78 8.7 0.9 2.4 2 1 0 2 2 2 0 Lycopene cyclase protein XdhC_C PF13478.6 AMD20259.1 - 0.13 12.7 0.0 8.1 7.0 0.0 2.5 2 0 0 2 2 2 0 XdhC Rossmann domain Trp_halogenase PF04820.14 AMD20259.1 - 0.28 10.0 4.7 0.98 8.2 0.4 2.3 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.6 AMD20259.1 - 0.31 11.5 3.1 3 8.3 0.3 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 AMD20259.1 - 0.91 9.4 6.3 0.1 12.5 0.4 2.5 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LSM PF01423.22 AMD20260.1 - 1.5e-17 63.1 0.0 1.6e-17 62.9 0.0 1.0 1 0 0 1 1 1 1 LSM domain Mannitol_dh_C PF08125.13 AMD20260.1 - 0.16 11.4 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain Acetyltransf_1 PF00583.25 AMD20261.1 - 1.1e-11 44.9 0.1 1.5e-11 44.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AMD20261.1 - 7.4e-07 29.5 0.0 1e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AMD20261.1 - 2.8e-05 24.0 0.0 3.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2781 PF10914.8 AMD20263.1 - 7.8e-37 126.9 12.3 8.8e-37 126.8 12.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DnaJ_C PF01556.18 AMD20264.1 - 1.5e-24 86.8 0.0 2.5e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AMD20264.1 - 2.8e-24 85.0 2.2 5.2e-24 84.1 2.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AMD20264.1 - 2.2e-10 40.7 22.0 3.5e-10 40.1 22.0 1.3 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 AMD20264.1 - 0.42 10.6 10.6 0.36 10.9 1.9 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Apolipoprotein PF01442.18 AMD20265.1 - 2e-08 34.3 25.8 7.9e-05 22.6 26.1 2.8 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 AMD20265.1 - 3.4e-07 30.8 30.8 0.002 18.7 6.0 4.1 1 1 3 4 4 4 4 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 AMD20265.1 - 1.4e-06 28.8 32.4 0.011 16.2 4.3 4.3 1 1 3 4 4 4 4 YtxH-like protein Synuclein PF01387.17 AMD20265.1 - 7e-05 23.0 18.7 7.2e-05 23.0 6.6 2.7 1 1 1 2 2 2 1 Synuclein ApoLp-III PF07464.11 AMD20265.1 - 0.0011 19.1 18.1 0.037 14.1 10.2 3.0 1 1 2 3 3 3 3 Apolipophorin-III precursor (apoLp-III) ApoO PF09769.9 AMD20265.1 - 0.024 14.6 12.0 3.4 7.6 0.5 3.7 1 1 2 3 3 3 0 Apolipoprotein O Prominin PF05478.11 AMD20265.1 - 0.033 12.2 5.1 0.026 12.5 1.2 1.9 1 1 1 2 2 2 0 Prominin DUF4456 PF14644.6 AMD20265.1 - 0.044 13.5 6.7 0.12 12.0 3.0 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4456) Phasin PF05597.11 AMD20265.1 - 0.16 12.0 24.0 0.12 12.4 3.5 3.8 1 1 3 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Tape_meas_lam_C PF09718.10 AMD20265.1 - 1.1 9.4 12.7 8.5 6.6 0.2 4.3 2 1 2 4 4 4 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) PIN_8 PF18476.1 AMD20265.1 - 1.9 8.3 14.9 1.2 8.9 11.7 2.0 1 1 1 2 2 2 0 PIN like domain Exonuc_VII_L PF02601.15 AMD20265.1 - 2.5 7.6 16.0 7.4 6.0 16.0 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit CREPT PF16566.5 AMD20265.1 - 2.8 8.1 11.2 1 9.5 2.0 2.2 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour SNARE PF05739.19 AMD20265.1 - 3.2 7.8 7.6 85 3.3 0.1 4.3 3 2 1 4 4 4 0 SNARE domain ParE_toxin PF05016.15 AMD20265.1 - 5.2 7.7 8.9 33 5.2 0.5 3.5 1 1 3 4 4 4 0 ParE toxin of type II toxin-antitoxin system, parDE EspB PF05802.11 AMD20265.1 - 7.7 6.4 28.4 13 5.7 4.9 2.9 1 1 1 2 2 2 0 Enterobacterial EspB protein HABP4_PAI-RBP1 PF04774.15 AMD20266.1 - 0.00092 20.0 0.1 0.0012 19.7 0.1 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family HTH_17 PF12728.7 AMD20266.1 - 0.14 12.3 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Gly_transf_sug PF04488.15 AMD20267.1 - 7.3e-20 71.4 0.0 1.4e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TMEM190 PF15431.6 AMD20267.1 - 0.25 11.5 2.3 1.7 8.8 0.1 2.7 3 0 0 3 3 3 0 Transmembrane protein 190 CTP_transf_like PF01467.26 AMD20268.1 - 3.4e-26 92.2 0.0 6.3e-21 75.1 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like Prp18 PF02840.15 AMD20269.1 - 7.8e-33 113.5 0.0 1.6e-32 112.5 0.0 1.5 1 1 0 1 1 1 1 Prp18 domain TFIIF_beta_N PF17683.1 AMD20270.1 - 7.3e-37 127.1 3.9 2e-36 125.7 3.9 1.8 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 AMD20270.1 - 6.5e-27 93.5 1.5 1.2e-26 92.7 1.5 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 AMD20270.1 - 0.0082 16.9 0.2 0.0082 16.9 0.2 2.3 1 1 1 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain UPF0242 PF06785.11 AMD20270.1 - 6.5 6.8 15.3 0.95 9.5 10.8 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Ribosomal_L38e PF01781.18 AMD20271.1 - 8e-26 89.9 0.9 8.9e-26 89.8 0.9 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Pex24p PF06398.11 AMD20272.1 - 1.5e-98 330.1 7.1 2.1e-98 329.7 7.1 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin zf-CCCH PF00642.24 AMD20273.1 - 6.8e-10 38.6 3.2 6.8e-10 38.6 3.2 1.8 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 AMD20273.1 - 4.2e-07 29.7 8.1 7.4e-07 28.9 8.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 AMD20273.1 - 1.8e-06 27.8 5.6 3.9e-06 26.7 5.6 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-RING_UBOX PF13445.6 AMD20273.1 - 5.7e-06 26.3 5.4 5.7e-06 26.3 5.4 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AMD20273.1 - 5.7e-06 26.1 10.6 5.7e-06 26.1 10.6 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD20273.1 - 1e-05 25.4 12.3 1.9e-05 24.5 12.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 AMD20273.1 - 4.9e-05 23.1 12.7 8.8e-05 22.3 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AMD20273.1 - 0.00021 21.1 7.9 0.00039 20.2 7.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 AMD20273.1 - 0.00029 21.1 9.9 0.0006 20.1 9.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-CCCH_4 PF18044.1 AMD20273.1 - 0.0003 20.5 1.8 0.0003 20.5 1.8 1.8 2 0 0 2 2 1 1 CCCH-type zinc finger zf-RING_10 PF16685.5 AMD20273.1 - 0.00082 19.5 6.7 0.00082 19.5 6.7 1.8 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 AMD20273.1 - 0.016 15.3 9.5 0.035 14.3 9.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.6 AMD20273.1 - 0.047 14.2 2.9 0.11 13.0 2.9 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-RING_6 PF14835.6 AMD20273.1 - 0.11 12.4 3.0 0.23 11.3 3.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.14 AMD20273.1 - 0.53 10.0 5.1 1 9.1 5.1 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-Sec23_Sec24 PF04810.15 AMD20273.1 - 2 8.6 8.0 2.3 8.3 5.0 2.2 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger C1_2 PF03107.16 AMD20273.1 - 2.2 8.7 11.3 13 6.2 0.3 2.6 1 1 1 2 2 2 0 C1 domain DUF4379 PF14311.6 AMD20273.1 - 8.5 6.8 8.5 7.2 7.1 4.2 2.9 3 0 0 3 3 3 0 Probable Zinc-ribbon domain Cullin PF00888.22 AMD20274.1 - 9.5e-140 467.1 15.3 9.5e-140 467.1 15.3 1.5 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 AMD20274.1 - 3.5e-15 55.8 1.7 1.4e-14 53.8 1.7 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain SPACA9 PF15120.6 AMD20274.1 - 0.015 15.0 0.1 0.045 13.5 0.1 1.8 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 PCI PF01399.27 AMD20274.1 - 0.072 13.6 3.1 0.49 10.9 0.0 3.6 4 0 0 4 4 4 0 PCI domain SANT_DAMP1_like PF16282.5 AMD20275.1 - 4.3e-26 90.9 4.0 4.3e-26 90.9 4.0 2.5 3 0 0 3 3 3 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 AMD20275.1 - 0.00013 22.0 1.2 0.00013 22.0 1.2 2.7 3 0 0 3 3 3 2 DNA methyltransferase 1-associated protein 1 (DMAP1) TusA PF01206.17 AMD20275.1 - 0.015 15.1 0.2 0.34 10.8 0.0 2.5 2 0 0 2 2 2 0 Sulfurtransferase TusA Myb_DNA-bind_6 PF13921.6 AMD20275.1 - 2.2 8.6 6.8 0.38 11.0 1.3 2.7 3 0 0 3 3 3 0 Myb-like DNA-binding domain Ubie_methyltran PF01209.18 AMD20276.1 - 6.1e-95 317.0 0.0 7e-95 316.8 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 AMD20276.1 - 8.9e-13 48.8 0.0 2.4e-12 47.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD20276.1 - 1.1e-10 41.9 0.0 2.2e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD20276.1 - 1.4e-10 41.2 0.0 2.2e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD20276.1 - 1.7e-09 38.3 0.0 3.4e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD20276.1 - 4e-05 23.5 0.0 5.9e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.17 AMD20276.1 - 0.019 14.6 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 AMD20276.1 - 0.045 13.7 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N PF00107.26 AMD20276.1 - 0.075 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_8 PF05148.15 AMD20276.1 - 0.14 11.9 0.0 0.52 10.1 0.0 1.9 1 1 1 2 2 2 0 Hypothetical methyltransferase Bul1_N PF04425.12 AMD20277.1 - 7.9e-153 509.4 0.0 7.9e-153 509.4 0.0 1.7 2 0 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.12 AMD20277.1 - 7.4e-97 324.0 9.5 7.4e-97 324.0 9.5 2.2 2 0 0 2 2 2 1 Bul1 C terminus CTK3_C PF12350.8 AMD20278.1 - 2.2e-15 56.5 4.6 4.4e-15 55.6 4.6 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.8 AMD20278.1 - 1e-05 25.5 0.0 4.7e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 CTD kinase subunit gamma CTK3 ubiquitin PF00240.23 AMD20280.1 - 2.1e-22 78.6 0.1 3.6e-22 77.9 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AMD20280.1 - 5.1e-13 48.7 0.0 8.1e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AMD20280.1 - 1.7e-06 28.4 0.0 3.4e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AMD20280.1 - 2.1e-05 24.6 0.1 5.1e-05 23.4 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 AMD20280.1 - 2.5e-05 24.0 0.1 7.7e-05 22.5 0.1 1.9 1 0 0 1 1 1 1 UBA/TS-N domain TBK1_ULD PF18396.1 AMD20280.1 - 0.0015 18.5 0.0 0.0025 17.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 AMD20280.1 - 0.0021 18.6 0.0 0.0036 17.8 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain GerD PF17898.1 AMD20280.1 - 0.0095 15.9 4.1 0.017 15.0 4.1 1.4 1 0 0 1 1 1 1 Spore germination GerD central core domain UN_NPL4 PF11543.8 AMD20280.1 - 0.017 15.6 0.1 0.027 15.0 0.1 1.3 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 HOIP-UBA PF16678.5 AMD20280.1 - 0.018 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair Ubiquitin_4 PF18036.1 AMD20280.1 - 0.041 13.9 0.1 3.4 7.8 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain Ubiquitin_5 PF18037.1 AMD20280.1 - 0.044 14.1 0.1 0.072 13.5 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain STI1 PF17830.1 AMD20280.1 - 1.6 8.7 14.1 1.1 9.2 3.1 2.8 1 1 1 2 2 2 0 STI1 domain TAF8_C PF10406.9 AMD20281.1 - 4.3e-17 62.4 0.2 4.3e-17 62.4 0.2 2.8 4 0 0 4 4 4 1 Transcription factor TFIID complex subunit 8 C-term SPR1 PF15356.6 AMD20281.1 - 0.39 11.2 11.7 0.85 10.2 11.7 1.5 1 0 0 1 1 1 0 Psoriasis susceptibility locus 2 NIF PF03031.18 AMD20282.1 - 3.9e-22 78.7 0.0 1.4e-21 76.9 0.0 2.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 AMD20282.1 - 3.3e-12 46.6 0.1 9.6e-12 45.1 0.1 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AMD20282.1 - 1.2e-06 28.3 0.0 2.5e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain Biotin_lipoyl_2 PF13533.6 AMD20282.1 - 8.3e-05 22.3 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like BRCT_2 PF16589.5 AMD20282.1 - 0.0085 16.5 0.0 0.021 15.2 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF4946 PF16304.5 AMD20282.1 - 0.057 13.1 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4946) HlyD_3 PF13437.6 AMD20282.1 - 0.097 13.4 0.0 11 6.8 0.0 2.6 2 0 0 2 2 2 0 HlyD family secretion protein PGM_PMM_I PF02878.16 AMD20283.1 - 3.6e-36 123.9 0.0 7.7e-36 122.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 AMD20283.1 - 2.4e-22 79.5 0.0 5.3e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 AMD20283.1 - 6e-14 52.2 0.0 9.9e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 AMD20283.1 - 2.7e-08 33.9 0.0 7.4e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Anp1 PF03452.14 AMD20284.1 - 5.1e-115 383.4 0.0 6.9e-115 383.0 0.0 1.2 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 AMD20284.1 - 0.0063 16.3 0.0 0.036 13.9 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 Asp PF00026.23 AMD20285.1 - 3e-42 145.2 0.4 3.7e-42 144.9 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 AMD20285.1 - 2.9e-10 40.2 0.2 2.4e-06 27.4 0.0 2.3 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal TAXi_N PF14543.6 AMD20285.1 - 0.0035 17.6 0.0 0.24 11.6 0.0 2.6 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Nab6_mRNP_bdg PF10567.9 AMD20286.1 - 2.4e-64 217.8 13.1 2.4e-64 217.8 13.1 3.8 4 2 0 4 4 4 1 RNA-recognition motif RRM PF10378.9 AMD20286.1 - 3.8e-18 64.9 9.4 3.8e-18 64.9 9.4 4.8 3 1 0 3 3 3 1 Putative RRM domain RRM_1 PF00076.22 AMD20286.1 - 0.0028 17.4 0.0 0.63 9.9 0.0 2.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAT1 PF09770.9 AMD20286.1 - 0.41 8.9 18.1 0.72 8.1 18.1 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tim54 PF11711.8 AMD20286.1 - 4.8 5.9 11.7 0.16 10.7 5.3 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Fungal_trans PF04082.18 AMD20287.1 - 1.7e-42 145.3 0.7 3.5e-42 144.3 0.7 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD20287.1 - 1.9e-10 40.7 13.0 3.3e-10 39.9 13.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PIG-L PF02585.17 AMD20288.1 - 3.7e-21 76.1 0.0 5.4e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.7 AMD20289.1 - 4.3e-29 100.7 0.8 1.1e-26 92.9 0.2 2.6 1 1 1 2 2 2 2 Mitochondrial ATPase expression NLE PF08154.12 AMD20289.1 - 0.13 12.8 0.2 0.37 11.3 0.2 1.8 1 0 0 1 1 1 0 NLE (NUC135) domain Exo_endo_phos PF03372.23 AMD20290.1 - 8.2e-27 94.2 0.0 1.1e-26 93.9 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ku PF02735.16 AMD20291.1 - 1e-22 80.8 0.0 1.9e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 AMD20291.1 - 4.2e-12 46.3 0.1 1.1e-11 44.9 0.1 1.8 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 AMD20291.1 - 0.041 14.6 0.6 0.16 12.7 0.6 2.0 1 1 0 1 1 1 0 Ku70/Ku80 C-terminal arm Rit1_C PF17184.4 AMD20292.1 - 1.1e-89 300.5 0.0 2.2e-89 299.5 0.0 1.4 2 0 0 2 2 2 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 AMD20292.1 - 1.6e-28 99.2 0.9 4.6e-28 97.7 0.3 2.2 3 0 0 3 3 3 1 Rit1 DUSP-like domain Ribosomal_L30 PF00327.20 AMD20293.1 - 9.1e-13 47.9 0.2 1.2e-12 47.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e RNB PF00773.19 AMD20295.1 - 2.4e-62 211.2 0.3 4e-62 210.4 0.3 1.4 1 0 0 1 1 1 1 RNB domain Pyr_redox_2 PF07992.14 AMD20296.1 - 6e-48 163.6 0.0 7.3e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AMD20296.1 - 4.7e-13 49.5 0.1 2.2e-09 37.7 0.2 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AMD20296.1 - 2.5e-06 26.9 1.5 0.41 9.8 0.1 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Mesothelin PF06060.12 AMD20296.1 - 0.1 10.8 0.0 0.21 9.7 0.0 1.4 2 0 0 2 2 2 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Gtr1_RagA PF04670.12 AMD20297.1 - 7.2e-94 313.5 0.6 7.2e-94 313.5 0.6 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 AMD20297.1 - 7.3e-08 32.7 0.0 1.9e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AMD20297.1 - 8.3e-08 32.0 0.1 1.4e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 Ras family Arf PF00025.21 AMD20297.1 - 1.3e-07 31.3 0.5 3.7e-07 29.8 0.1 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD20297.1 - 1.4e-07 31.6 0.0 4.3e-07 30.0 0.0 1.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 AMD20297.1 - 0.0075 16.8 0.1 0.016 15.7 0.1 1.8 1 1 0 1 1 1 1 ABC transporter SopD PF11047.8 AMD20297.1 - 0.016 14.4 0.7 0.03 13.5 0.7 1.4 1 0 0 1 1 1 0 Salmonella outer protein D RsgA_GTPase PF03193.16 AMD20297.1 - 0.02 14.8 2.1 0.33 10.9 0.1 2.7 3 0 0 3 3 3 0 RsgA GTPase AIG1 PF04548.16 AMD20297.1 - 0.031 13.6 0.7 0.35 10.2 0.1 2.2 1 1 1 2 2 2 0 AIG1 family DUF815 PF05673.13 AMD20297.1 - 0.032 13.4 0.0 0.08 12.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) PqqD PF05402.12 AMD20297.1 - 0.064 13.6 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) AAA_29 PF13555.6 AMD20297.1 - 0.14 12.0 0.2 0.3 10.9 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pept_tRNA_hydro PF01195.19 AMD20298.1 - 3.9e-31 108.3 0.0 4.6e-31 108.1 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase SQS_PSY PF00494.19 AMD20299.1 - 6.5e-41 140.6 0.0 7.9e-41 140.3 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase MitMem_reg PF13012.6 AMD20299.1 - 0.36 11.3 1.5 2.6 8.5 0.0 2.7 3 0 0 3 3 3 0 Maintenance of mitochondrial structure and function Ku PF02735.16 AMD20300.1 - 1.8e-31 109.5 0.0 3.3e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 AMD20300.1 - 4.2e-24 85.5 0.0 8.3e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 AMD20300.1 - 0.005 17.5 0.1 0.015 16.0 0.0 1.9 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm VWA PF00092.28 AMD20300.1 - 0.022 15.0 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Sugar_tr PF00083.24 AMD20301.1 - 5.8e-44 150.7 20.0 7e-44 150.4 20.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD20301.1 - 1e-21 77.3 11.8 1.8e-12 46.9 11.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ost4 PF10215.9 AMD20301.1 - 0.8 9.6 9.5 1.4 8.8 0.6 3.3 3 0 0 3 3 3 0 Oligosaccaryltransferase Tubulin PF00091.25 AMD20302.1 - 2.1e-67 227.2 0.0 2.9e-67 226.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AMD20302.1 - 1.4e-49 167.4 0.0 2.2e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain ALO PF04030.14 AMD20303.1 - 2.5e-102 342.2 0.6 5.5e-102 341.0 0.2 1.7 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 AMD20303.1 - 5.7e-27 94.2 0.0 8.1e-27 93.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_6 PF00970.24 AMD20304.1 - 2.3e-29 101.7 0.0 3.4e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 AMD20304.1 - 5.9e-29 100.9 0.0 8.5e-29 100.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 AMD20304.1 - 2.5e-07 30.9 0.0 4.3e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 AMD20304.1 - 0.022 15.0 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain F-box-like PF12937.7 AMD20305.1 - 1.9e-10 40.5 0.0 3.5e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AMD20305.1 - 2.3e-06 27.3 0.0 4.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 AMD20305.1 - 0.015 15.2 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 F-box FAM131 PF15010.6 AMD20305.1 - 0.023 14.6 0.9 0.048 13.6 0.9 1.5 1 0 0 1 1 1 0 Putative cell signalling CPBP PF02517.16 AMD20307.1 - 2.2e-15 56.8 3.4 2.2e-15 56.8 3.4 2.3 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease Zds_C PF08632.10 AMD20308.1 - 6.8e-30 102.6 1.7 1.4e-29 101.6 1.7 1.6 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF1892 PF08987.10 AMD20309.1 - 1.4e-44 150.7 1.3 1.8e-44 150.4 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) Cyt-b5 PF00173.28 AMD20310.1 - 5.5e-14 52.1 0.3 7.1e-13 48.5 0.0 2.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 AMD20310.1 - 2.8e-13 50.4 19.2 2.8e-13 50.4 19.2 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 AMD20310.1 - 0.00085 19.5 0.3 0.0022 18.2 0.3 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region DUF4071 PF13281.6 AMD20310.1 - 0.032 13.3 0.5 0.046 12.8 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4071) TMEM189_B_dmain PF10520.9 AMD20310.1 - 4.4 7.4 10.2 16 5.5 3.2 2.7 2 1 1 3 3 3 0 B domain of TMEM189, localisation domain CPDase PF07823.11 AMD20311.1 - 7.2e-75 251.1 0.7 8.2e-75 250.9 0.7 1.0 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 AMD20311.1 - 0.0025 17.7 0.7 0.98 9.3 0.1 2.2 1 1 0 2 2 2 2 2'-5' RNA ligase superfamily DUF3051 PF11252.8 AMD20311.1 - 0.098 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) Cnl2_NKP2 PF09447.10 AMD20311.1 - 0.1 12.8 0.1 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 Cnl2/NKP2 family protein TFIIB PF00382.19 AMD20312.1 - 3.9e-55 183.8 1.6 6.2e-28 96.7 0.1 2.8 3 0 0 3 3 3 2 Transcription factor TFIIB repeat BRF1 PF07741.13 AMD20312.1 - 5.2e-31 107.0 0.5 5.2e-31 107.0 0.5 3.3 2 1 1 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 AMD20312.1 - 8.7e-13 47.6 3.2 1.6e-12 46.7 3.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 AMD20312.1 - 0.00016 21.4 0.3 0.48 10.2 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Zn-ribbon_8 PF09723.10 AMD20312.1 - 0.18 11.9 2.0 0.46 10.6 2.0 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Vps36-NZF-N PF16988.5 AMD20312.1 - 1.3 8.4 3.7 4.2 6.9 0.1 2.8 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain SDA1 PF05285.12 AMD20313.1 - 4.5e-86 289.4 44.0 2.2e-45 155.6 11.7 3.1 2 1 1 3 3 3 3 SDA1 NUC130_3NT PF08158.12 AMD20313.1 - 2.3e-21 75.9 0.2 6.5e-21 74.4 0.2 1.9 1 0 0 1 1 1 1 NUC130/3NT domain ATP-grasp_2 PF08442.10 AMD20314.1 - 1.3e-71 240.4 0.5 2e-71 239.7 0.5 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 AMD20314.1 - 2.3e-26 92.4 0.3 9.2e-26 90.5 0.1 2.2 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 AMD20314.1 - 8.3e-06 25.4 0.3 1.4e-05 24.6 0.3 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 AMD20314.1 - 0.0056 16.5 0.1 0.017 14.9 0.1 1.7 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF1678 PF07913.11 AMD20314.1 - 0.095 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1678) MPC PF03650.13 AMD20315.1 - 2.8e-48 162.6 0.1 3.3e-48 162.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers ANTH PF07651.16 AMD20317.1 - 1.6e-58 197.9 0.2 1.6e-58 197.9 0.2 1.5 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.20 AMD20317.1 - 1.1e-06 28.7 0.0 5e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 ENTH domain PFK PF00365.20 AMD20318.1 - 1.2e-183 608.8 3.1 9.2e-105 350.0 0.6 2.2 2 0 0 2 2 2 2 Phosphofructokinase Pfk_N PF18468.1 AMD20318.1 - 1.7e-26 92.5 0.4 3.9e-26 91.3 0.1 1.9 2 0 0 2 2 2 1 Phosphofructokinase N-terminal domain yeast DAGK_cat PF00781.24 AMD20318.1 - 0.012 15.3 0.1 0.11 12.1 0.1 2.5 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain NTP_transf_2 PF01909.23 AMD20319.1 - 2.3e-18 66.3 0.1 1.8e-17 63.4 0.0 2.6 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 AMD20319.1 - 2.9e-14 53.0 1.1 4.8e-14 52.3 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase DUF3835 PF12927.7 AMD20319.1 - 8.6 7.3 8.3 1.8 9.5 0.9 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3835) RF-1 PF00472.20 AMD20320.1 - 4e-19 68.7 2.3 6.3e-19 68.0 2.3 1.2 1 0 0 1 1 1 1 RF-1 domain Pkinase PF00069.25 AMD20321.1 - 3.7e-66 223.2 0.4 8.5e-65 218.7 0.4 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20321.1 - 1.4e-50 172.0 0.3 2e-50 171.5 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 AMD20321.1 - 5.7e-23 81.0 0.1 1.4e-22 79.8 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 AMD20321.1 - 2.8e-07 30.2 0.1 6.4e-07 29.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like PH PF00169.29 AMD20321.1 - 5.2e-07 30.1 1.0 1.1e-06 29.0 1.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 AMD20321.1 - 1.5e-05 23.9 0.0 3.2e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 AMD20321.1 - 0.014 14.5 0.1 0.023 13.7 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 AMD20321.1 - 0.015 15.2 0.0 0.052 13.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family DCB PF16213.5 AMD20322.1 - 5.2e-49 166.3 1.4 5.2e-49 166.3 1.4 4.4 3 1 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 AMD20322.1 - 1.4e-34 119.2 7.0 1.4e-34 119.2 7.0 6.2 6 3 1 7 7 7 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 AMD20322.1 - 6.6e-14 51.0 1.6 1.8e-07 29.8 0.1 3.1 2 1 0 3 3 3 2 C-terminal region of Mon2 protein HMw1_D2 PF18254.1 AMD20322.1 - 0.12 12.7 0.1 2.4 8.6 0.0 2.9 2 0 0 2 2 2 0 HMW1 domain 2 DUF45 PF01863.17 AMD20323.1 - 0.038 14.0 0.2 0.071 13.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 PalH PF08733.10 AMD20324.1 - 3.1e-62 210.5 12.8 4.2e-62 210.1 12.8 1.1 1 0 0 1 1 1 1 PalH/RIM21 RabGAP-TBC PF00566.18 AMD20325.1 - 8.7e-45 153.0 0.2 3.5e-44 151.0 0.1 2.0 2 1 0 2 2 2 1 Rab-GTPase-TBC domain Get5_bdg PF16843.5 AMD20326.1 - 3.6e-15 55.2 0.0 7.2e-15 54.2 0.0 1.5 1 0 0 1 1 1 1 Binding domain to Get4 on Get5, Golgi to ER traffic protein Get5_C PF18514.1 AMD20326.1 - 4.1e-10 39.2 1.0 1.2e-08 34.5 0.1 2.5 2 0 0 2 2 2 1 Get5 C-terminal domain ubiquitin PF00240.23 AMD20326.1 - 0.00049 19.8 0.1 0.00078 19.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 AMD20326.1 - 0.042 14.4 0.2 0.074 13.6 0.1 1.5 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Erf4 PF10256.9 AMD20327.1 - 6.1e-32 110.2 0.0 8.4e-32 109.7 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family RcbX PF02341.15 AMD20327.1 - 0.22 11.8 0.4 17 5.7 0.1 2.2 1 1 0 2 2 2 0 RbcX protein TruB_N PF01509.18 AMD20328.1 - 9.7e-43 146.1 0.2 5.3e-39 134.0 0.0 2.7 2 1 1 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 AMD20328.1 - 5.3e-05 23.3 0.0 0.0002 21.4 0.0 2.0 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain Mid1 PF12929.7 AMD20329.1 - 2.8e-114 382.6 4.4 3.3e-114 382.4 4.4 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 AMD20329.1 - 0.00087 19.9 4.4 0.03 14.9 4.4 2.6 1 1 0 1 1 1 1 Fz domain AAA PF00004.29 AMD20330.1 - 1.9e-18 67.2 0.0 3.2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AMD20330.1 - 5.5e-16 58.8 0.0 1.3e-12 47.8 0.2 2.4 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 AMD20330.1 - 1.4e-12 47.9 1.1 3.2e-12 46.7 0.1 2.2 3 0 0 3 3 1 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 AMD20330.1 - 1.4e-07 31.7 0.1 4.9e-07 30.0 0.1 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 AMD20330.1 - 1.4e-06 28.8 0.1 3.4e-06 27.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 AMD20330.1 - 2.4e-06 27.6 0.0 6.1e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain DUF815 PF05673.13 AMD20330.1 - 4.8e-06 25.9 0.0 7.7e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 AMD20330.1 - 5.8e-06 26.6 0.6 0.14 12.4 0.0 2.7 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.12 AMD20330.1 - 7.6e-06 25.8 0.0 1.8e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 AMD20330.1 - 1.3e-05 25.0 0.1 0.00021 21.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AMD20330.1 - 4.3e-05 23.3 0.0 7.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 AMD20330.1 - 5.6e-05 23.2 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AMD20330.1 - 0.00029 20.8 0.0 0.0012 18.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 AMD20330.1 - 0.00034 20.5 0.1 0.0009 19.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AMD20330.1 - 0.00048 20.0 0.0 0.00094 19.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 AMD20330.1 - 0.00048 20.2 0.0 0.16 11.9 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DNA_pol3_delta PF06144.13 AMD20330.1 - 0.00064 19.6 0.2 0.0012 18.7 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_7 PF12775.7 AMD20330.1 - 0.00073 19.1 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region DEAD PF00270.29 AMD20330.1 - 0.00091 19.0 0.4 0.0079 16.0 0.1 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase Mg_chelatase PF01078.21 AMD20330.1 - 0.0012 18.3 0.0 0.0084 15.5 0.0 2.0 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AMD20330.1 - 0.002 18.6 0.1 0.0063 17.1 0.1 1.9 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 AMD20330.1 - 0.0045 17.3 0.6 0.28 11.5 0.1 2.5 2 1 1 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 AMD20330.1 - 0.0052 16.5 0.0 0.011 15.5 0.0 1.7 1 1 0 1 1 1 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 AMD20330.1 - 0.0061 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 AMD20330.1 - 0.0088 16.3 0.0 0.02 15.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 AMD20330.1 - 0.011 16.2 0.0 0.022 15.1 0.0 1.6 1 1 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 AMD20330.1 - 0.03 14.2 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Methyltransf_31 PF13847.6 AMD20330.1 - 0.031 14.1 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TniB PF05621.11 AMD20330.1 - 0.033 13.6 0.0 0.68 9.3 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 AMD20330.1 - 0.041 13.4 0.0 1 8.9 0.0 2.2 1 1 1 2 2 2 0 AAA domain SRP54 PF00448.22 AMD20330.1 - 0.054 13.1 0.0 0.13 11.9 0.0 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain SNF2_N PF00176.23 AMD20330.1 - 0.068 11.9 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_33 PF13671.6 AMD20330.1 - 0.073 13.2 0.1 0.18 12.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain Cyclin_N PF00134.23 AMD20331.1 - 5.1e-20 71.5 0.0 8.2e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AMD20331.1 - 5e-08 33.5 1.1 8.3e-08 32.8 0.0 1.8 2 0 0 2 2 2 1 Cyclin RR_TM4-6 PF06459.12 AMD20332.1 - 0.039 13.8 14.9 0.042 13.7 14.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DHHW PF14286.6 AMD20332.1 - 3.2 7.0 6.4 3.3 6.9 6.4 1.0 1 0 0 1 1 1 0 DHHW protein Rcd1 PF04078.13 AMD20333.1 - 2.2e-115 384.4 3.7 2.8e-115 384.1 3.7 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like TFIIA PF03153.13 AMD20333.1 - 7.4 6.4 10.2 11 5.9 10.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Adaptin_N PF01602.20 AMD20334.1 - 2.1e-105 353.3 12.6 3e-105 352.7 12.6 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 AMD20334.1 - 5.4e-48 163.0 0.8 1.1e-47 161.9 0.8 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 AMD20334.1 - 9.2e-25 87.0 1.0 2e-24 86.0 0.4 1.9 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 AMD20334.1 - 7.3e-11 42.3 0.0 0.0031 17.9 0.0 4.4 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 AMD20334.1 - 0.0017 18.4 1.9 52 4.5 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat Cnd1 PF12717.7 AMD20334.1 - 0.0059 16.7 10.6 0.25 11.4 0.9 4.8 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 EPO_TPO PF00758.18 AMD20334.1 - 0.0077 16.3 1.3 0.22 11.6 0.1 3.1 3 0 0 3 3 3 1 Erythropoietin/thrombopoietin DUF2780 PF11075.8 AMD20334.1 - 0.012 15.8 0.1 0.032 14.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function VcgC/VcgE (DUF2780) Pkinase PF00069.25 AMD20335.1 - 5.6e-48 163.6 0.0 9.5e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20335.1 - 7e-29 100.9 0.0 1.1e-28 100.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20335.1 - 0.089 12.1 0.0 1 8.6 0.0 2.2 1 1 1 2 2 2 0 Kinase-like APH PF01636.23 AMD20335.1 - 0.19 11.6 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mannosyl_trans3 PF11051.8 AMD20336.1 - 1.5e-78 263.9 0.0 2.3e-78 263.3 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative muHD PF10291.9 AMD20337.1 - 2.9e-65 220.3 0.0 4.8e-65 219.6 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Arfaptin PF06456.13 AMD20337.1 - 0.34 10.5 3.5 0.18 11.3 0.6 1.9 2 0 0 2 2 2 0 Arfaptin-like domain SSB PF00436.25 AMD20339.1 - 1e-18 67.3 0.0 1.2e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Gon7 PF08738.10 AMD20340.1 - 1.7e-38 131.0 0.1 1.9e-38 130.8 0.1 1.0 1 0 0 1 1 1 1 Gon7 family MutS_IV PF05190.18 AMD20340.1 - 0.044 14.1 0.1 0.1 13.0 0.1 1.5 1 0 0 1 1 1 0 MutS family domain IV MFS_1 PF07690.16 AMD20341.1 - 9e-29 100.5 21.6 9e-29 100.5 21.6 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 AMD20341.1 - 8.9e-06 25.2 0.7 8.9e-06 25.2 0.7 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Baculo_p74 PF04583.12 AMD20341.1 - 0.14 11.7 1.3 0.32 10.5 1.3 1.7 1 1 0 1 1 1 0 Baculoviridae p74 conserved region DUF3792 PF12670.7 AMD20341.1 - 1.8 8.8 11.9 0.25 11.5 4.2 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3792) Glyco_transf_34 PF05637.12 AMD20342.1 - 2.5e-47 161.6 0.1 3.3e-47 161.2 0.1 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family ATP12 PF07542.11 AMD20344.1 - 4e-35 120.7 0.0 7.3e-35 119.9 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.20 AMD20345.1 - 6.6e-16 58.2 4.2 7.4e-16 58.0 4.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit Eaf7 PF07904.13 AMD20345.1 - 0.041 14.3 0.6 0.053 13.9 0.6 1.2 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 ATG27 PF09451.10 AMD20346.1 - 1.6e-40 139.7 0.2 1.8e-40 139.5 0.2 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 FixP_N PF14715.6 AMD20346.1 - 4.9 7.0 7.2 9.7 6.0 7.2 1.4 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Ribosomal_L22 PF00237.19 AMD20347.1 - 8.9e-38 128.7 0.2 8.9e-38 128.7 0.2 1.4 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e CRT10 PF08728.10 AMD20347.1 - 0.12 10.5 0.3 0.13 10.4 0.3 1.0 1 0 0 1 1 1 0 CRT10 CASP_C PF08172.12 AMD20348.1 - 1.5e-61 207.9 8.6 1.5e-61 207.9 8.6 3.5 2 1 0 3 3 3 1 CASP C terminal GIT_CC PF16559.5 AMD20348.1 - 0.02 14.7 3.3 0.02 14.7 3.3 6.3 8 0 0 8 8 8 0 GIT coiled-coil Rho guanine nucleotide exchange factor NPV_P10 PF05531.12 AMD20348.1 - 0.057 13.9 0.5 0.057 13.9 0.5 3.7 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Mobilization_B PF17511.2 AMD20348.1 - 0.64 10.4 6.5 0.17 12.2 1.9 2.4 3 0 0 3 3 3 0 Mobilization protein B WD40_alt PF14077.6 AMD20348.1 - 1.7 8.6 8.9 15 5.5 0.1 5.1 5 0 0 5 5 5 0 Alternative WD40 repeat motif ADIP PF11559.8 AMD20348.1 - 4.7 7.3 58.9 0.052 13.6 0.8 6.9 4 2 3 7 7 7 0 Afadin- and alpha -actinin-Binding SWIRM PF04433.17 AMD20349.1 - 5.8e-28 97.1 0.2 1.3e-27 95.9 0.2 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 AMD20349.1 - 1.3e-22 79.6 5.2 1.3e-22 79.6 5.2 2.0 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 AMD20349.1 - 5.9e-12 45.6 0.0 1.4e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD20349.1 - 4.9e-09 36.3 0.0 1.4e-08 34.9 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 AMD20349.1 - 0.18 11.7 0.0 0.18 11.7 0.0 3.6 4 1 0 4 4 4 0 Myb DNA-binding like YgaB PF14182.6 AMD20349.1 - 1 9.8 11.4 0.95 9.9 2.4 2.8 2 0 0 2 2 2 0 YgaB-like protein KRE9 PF05390.11 AMD20350.1 - 2.3e-19 70.0 7.7 4.3e-19 69.1 7.7 1.4 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 Rep_fac-A_3 PF08661.11 AMD20351.1 - 5.9e-27 94.1 0.0 6.6e-27 93.9 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Phage-Gp8 PF09215.10 AMD20351.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage T4, Gp8 STE3 PF02076.15 AMD20353.1 - 7.5e-80 268.2 11.9 1.1e-79 267.7 11.9 1.2 1 0 0 1 1 1 1 Pheromone A receptor DUF2401 PF10287.9 AMD20354.1 - 1e-66 224.8 0.0 1.6e-66 224.2 0.0 1.3 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 AMD20354.1 - 1.3e-18 67.2 0.0 3.2e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) TFIIF_alpha PF05793.12 AMD20354.1 - 0.0023 16.6 34.7 0.0033 16.1 34.7 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 AMD20354.1 - 0.011 15.1 34.0 0.016 14.7 34.0 1.1 1 0 0 1 1 1 0 SDA1 Merozoite_SPAM PF07133.11 AMD20354.1 - 0.52 10.3 39.3 0.77 9.7 39.3 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) BUD22 PF09073.10 AMD20354.1 - 0.59 9.4 33.2 0.82 8.9 33.2 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 AMD20354.1 - 5.3 5.1 37.7 7.3 4.7 37.7 1.1 1 0 0 1 1 1 0 Nop14-like family LAP1C PF05609.12 AMD20354.1 - 6.7 5.7 12.7 9.2 5.2 12.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SAPS PF04499.15 AMD20354.1 - 7.7 5.2 13.0 10 4.8 13.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Baculo_11_kDa PF06143.11 AMD20355.1 - 0.0079 15.7 0.2 0.014 14.9 0.2 1.5 1 0 0 1 1 1 1 Baculovirus 11 kDa family CrgA PF06781.12 AMD20355.1 - 0.65 10.1 3.0 1.2 9.2 0.2 2.2 2 1 0 2 2 2 0 Cell division protein CrgA SRI PF08236.11 AMD20356.1 - 1.8e-22 79.3 9.3 1.8e-22 79.3 9.3 2.3 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 AMD20356.1 - 1.4e-19 71.1 0.3 1.4e-19 71.1 0.3 4.2 3 1 1 4 4 4 1 SET domain WW_1 PF18507.1 AMD20356.1 - 2.6e-17 62.2 0.7 5.6e-17 61.1 0.7 1.6 1 0 0 1 1 1 1 WW domain AWS PF17907.1 AMD20356.1 - 5.7e-16 58.3 10.8 5.7e-16 58.3 10.8 3.2 3 0 0 3 3 3 1 AWS domain Longin_2 PF18639.1 AMD20357.1 - 3.8e-54 183.0 0.2 9.6e-54 181.7 0.0 1.8 2 0 0 2 2 2 1 Yeast longin domain Zip PF02535.22 AMD20358.1 - 1.8e-17 63.6 13.2 1.5e-16 60.6 13.2 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter H_PPase PF03030.16 AMD20358.1 - 0.0013 17.4 0.9 0.0013 17.4 0.9 1.6 2 0 0 2 2 2 1 Inorganic H+ pyrophosphatase DUF1218 PF06749.12 AMD20358.1 - 0.015 15.8 2.4 0.037 14.5 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) AA_permease PF00324.21 AMD20359.1 - 1.6e-49 168.8 42.9 2.2e-49 168.4 42.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD20359.1 - 5.3e-34 117.8 42.9 6.4e-34 117.5 42.9 1.0 1 0 0 1 1 1 1 Amino acid permease GTP_EFTU PF00009.27 AMD20360.1 - 2.7e-35 121.7 0.0 4e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AMD20360.1 - 9.9e-16 57.6 0.0 2e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 AMD20360.1 - 4.4e-15 55.5 0.0 9.8e-15 54.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFTUD2 PF16004.5 AMD20360.1 - 3.2e-07 31.0 3.5 0.00013 22.5 0.7 2.4 1 1 1 2 2 2 2 116 kDa U5 small nuclear ribonucleoprotein component N-terminus GTP_EFTU_D2 PF03144.25 AMD20360.1 - 8.9e-07 29.2 0.0 2.1e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 AMD20360.1 - 3.1e-05 24.0 0.0 7.2e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II RsgA_GTPase PF03193.16 AMD20360.1 - 0.053 13.4 0.0 0.86 9.5 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase Roc PF08477.13 AMD20360.1 - 0.13 12.5 0.0 6.6 7.0 0.0 2.4 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Virul_Fac PF10139.9 AMD20360.1 - 0.24 9.6 0.0 0.36 9.0 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor Ebp2 PF05890.12 AMD20361.1 - 1.5e-87 293.6 29.7 1.5e-87 293.6 29.7 2.6 1 1 2 3 3 3 1 Eukaryotic rRNA processing protein EBP2 polyprenyl_synt PF00348.17 AMD20362.1 - 5.7e-92 307.4 0.0 6.9e-92 307.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase UcrQ PF02939.16 AMD20363.1 - 1.1e-33 115.0 1.1 1.2e-33 114.8 1.1 1.0 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 AMD20363.1 - 0.002 18.5 0.1 0.0027 18.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 Pkinase PF00069.25 AMD20364.1 - 1e-34 120.1 0.0 4.4e-21 75.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20364.1 - 6.5e-20 71.5 0.0 5.4e-16 58.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AMD20364.1 - 0.0025 17.2 0.0 1.2 8.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like YrbL-PhoP_reg PF10707.9 AMD20364.1 - 0.044 13.3 0.1 0.16 11.4 0.0 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Ribosomal_L14 PF00238.19 AMD20365.1 - 2.6e-40 137.3 1.9 3e-40 137.1 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Mitoc_L55 PF09776.9 AMD20365.1 - 0.17 11.6 0.1 0.24 11.2 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 Pkinase PF00069.25 AMD20366.1 - 2.2e-42 145.2 0.0 5.2e-42 144.0 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20366.1 - 4.3e-18 65.5 0.1 1e-17 64.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20366.1 - 0.041 13.2 0.0 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 AMD20366.1 - 0.079 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4477 PF14780.6 AMD20366.1 - 0.083 12.5 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) Ral PF11058.8 AMD20366.1 - 0.11 12.1 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 Antirestriction protein Ral Kdo PF06293.14 AMD20366.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LrgB PF04172.16 AMD20367.1 - 1.3e-41 142.5 7.1 1.3e-41 142.5 7.1 2.5 2 1 0 2 2 2 1 LrgB-like family LrgA PF03788.14 AMD20367.1 - 0.00093 19.1 3.2 0.00093 19.1 3.2 2.6 2 0 0 2 2 2 1 LrgA family L51_S25_CI-B8 PF05047.16 AMD20368.1 - 3.8e-15 55.5 0.6 7.3e-15 54.6 0.6 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MFS_1 PF07690.16 AMD20369.1 - 2.4e-15 56.3 20.7 2.4e-15 56.3 20.7 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TNFR_16_TM PF18422.1 AMD20369.1 - 0.16 12.0 0.2 0.16 12.0 0.2 2.7 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain FA_desaturase PF00487.24 AMD20369.1 - 4.1 7.2 6.6 3.9 7.2 0.7 2.8 2 1 1 3 3 3 0 Fatty acid desaturase PigN PF04987.14 AMD20370.1 - 5.1e-129 431.1 39.4 7.9e-129 430.5 39.4 1.3 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 AMD20370.1 - 2.4e-13 50.4 1.0 1.3e-10 41.4 0.1 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 AMD20370.1 - 6.9e-11 42.1 0.1 1.1e-10 41.4 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 AMD20370.1 - 0.00012 21.5 0.0 0.00021 20.8 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Cas_DxTHG PF09455.10 AMD20370.1 - 0.015 14.9 2.0 0.016 14.8 0.4 1.7 2 0 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family DnaJ PF00226.31 AMD20371.1 - 2.2e-19 69.3 0.6 5.7e-19 68.0 0.6 1.8 1 0 0 1 1 1 1 DnaJ domain Tom37 PF10568.9 AMD20371.1 - 0.2 12.0 1.5 22 5.4 0.0 2.6 3 0 0 3 3 3 0 Outer mitochondrial membrane transport complex protein CENP-F_leu_zip PF10473.9 AMD20371.1 - 0.91 9.5 5.8 0.57 10.2 1.0 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PIR PF00399.19 AMD20374.1 - 2e-21 75.0 34.6 5.7e-06 25.7 1.9 5.9 5 0 0 5 5 5 5 Yeast PIR protein repeat PIR PF00399.19 AMD20375.1 - 5.7e-05 22.6 14.3 0.00084 18.8 0.6 3.6 3 0 0 3 3 3 2 Yeast PIR protein repeat ATP-synt_ab PF00006.25 AMD20376.1 - 5.3e-62 209.3 0.0 8.3e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AMD20376.1 - 1.6e-22 79.8 2.4 1.6e-22 79.8 2.4 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 AMD20376.1 - 0.0045 16.4 0.2 0.0075 15.6 0.2 1.3 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 AMD20376.1 - 0.0049 16.1 0.7 0.077 12.2 0.1 2.1 2 0 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 AMD20376.1 - 0.037 13.9 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 AMD20376.1 - 0.037 13.9 0.1 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 NACHT domain T3SS_ATPase_C PF18269.1 AMD20376.1 - 0.046 13.6 0.7 0.29 11.0 0.7 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA PF00004.29 AMD20376.1 - 0.071 13.5 0.1 0.77 10.2 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 AMD20376.1 - 0.095 13.0 0.7 0.47 10.8 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AMD20376.1 - 0.099 13.0 0.8 0.29 11.5 0.2 2.1 2 1 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 AMD20376.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Pox_A32 PF04665.12 AMD20376.1 - 0.23 10.9 0.1 0.5 9.8 0.1 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein GCV_T PF01571.21 AMD20377.1 - 0.074 12.4 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 Aminomethyltransferase folate-binding domain Ribosomal_S7 PF00177.21 AMD20378.1 - 3.9e-37 127.2 2.1 5.4e-37 126.7 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e MFS_1 PF07690.16 AMD20379.1 - 3.2e-26 92.1 24.6 6.3e-20 71.4 18.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 AMD20379.1 - 8.5e-10 37.7 29.8 4.2e-06 25.6 6.4 3.0 1 1 2 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.7 AMD20379.1 - 3.4e-07 29.4 23.8 2.7e-05 23.2 7.6 2.2 1 1 1 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 AMD20379.1 - 0.00057 18.9 20.3 0.0017 17.3 20.2 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter Zn_clus PF00172.18 AMD20380.1 - 8.6e-07 29.0 10.6 2.2e-06 27.7 10.6 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF753 PF05444.12 AMD20380.1 - 1.2 9.1 16.4 0.073 13.1 10.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF753) eIF2_C PF09173.11 AMD20381.1 - 1e-34 118.6 0.3 2.7e-34 117.3 0.3 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 AMD20381.1 - 2.8e-23 82.5 0.3 2.5e-22 79.4 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 AMD20381.1 - 2.7e-12 46.9 0.4 1e-11 45.0 0.4 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AMD20381.1 - 0.003 17.6 0.0 0.0064 16.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD20381.1 - 0.0065 16.4 0.1 0.082 12.8 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 AMD20381.1 - 0.047 13.7 0.1 0.13 12.3 0.1 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RGS PF00615.19 AMD20382.1 - 1.1e-17 64.4 0.8 1.8e-10 41.1 0.1 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.21 AMD20382.1 - 2.5e-11 43.5 0.1 3.7e-08 33.3 0.0 2.9 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase PF00069.25 AMD20383.1 - 8.3e-74 248.3 0.0 1e-73 247.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20383.1 - 8.5e-31 107.2 0.0 1.2e-29 103.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD20383.1 - 3.2e-07 29.7 0.0 4.8e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain ORC4_C PF14629.6 AMD20384.1 - 1.5e-33 116.1 4.1 1.5e-33 116.1 4.1 1.5 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 AMD20384.1 - 0.0001 22.7 0.7 0.00027 21.3 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 AMD20384.1 - 0.01 16.2 0.1 0.028 14.8 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD20384.1 - 0.015 15.6 0.1 0.047 14.0 0.1 1.9 1 0 0 1 1 1 0 AAA domain FTHFS PF01268.19 AMD20384.1 - 0.03 12.5 0.1 0.054 11.7 0.1 1.3 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase FliG_C PF01706.16 AMD20384.1 - 0.037 14.2 0.9 0.18 12.0 0.1 2.6 2 1 1 3 3 3 0 FliG C-terminal domain RRM_1 PF00076.22 AMD20385.1 - 5.7e-05 22.9 0.0 0.00015 21.5 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Herpes_UL7 PF01677.16 AMD20385.1 - 0.0048 16.6 0.0 0.0081 15.9 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus UL7 like Pentapeptide PF00805.22 AMD20385.1 - 2.3 8.0 7.7 36 4.1 0.1 4.7 7 0 0 7 7 7 0 Pentapeptide repeats (8 copies) Fmp27 PF10344.9 AMD20386.1 - 5.1e-98 329.3 13.5 7.7e-98 328.7 13.5 1.3 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 AMD20386.1 - 6.4e-94 315.5 1.9 1.1e-93 314.7 1.9 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.9 AMD20386.1 - 4.5e-81 273.1 13.6 2.6e-79 267.3 13.6 2.3 1 1 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 AMD20386.1 - 2.8e-54 183.4 0.0 6e-54 182.4 0.0 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 AMD20386.1 - 4.3e-53 179.4 0.8 2.4e-52 176.9 0.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 AMD20386.1 - 2.5e-29 102.0 0.1 4.2e-28 98.1 0.0 3.2 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Ras PF00071.22 AMD20388.1 - 4e-52 176.1 0.0 4.8e-52 175.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD20388.1 - 1.5e-20 73.6 0.0 2.2e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD20388.1 - 4.3e-08 32.8 0.0 6.4e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 AMD20389.1 - 2.5e-55 186.5 0.0 2.9e-55 186.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD20389.1 - 3.4e-21 75.7 0.0 5.2e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD20389.1 - 9.3e-07 28.5 0.0 1.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AMD20389.1 - 6.7e-05 22.5 0.0 0.00018 21.1 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 AMD20389.1 - 0.089 12.1 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 AMD20389.1 - 0.11 12.4 0.0 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Ribosomal_S14 PF00253.21 AMD20390.1 - 1.9e-21 75.5 0.3 4e-21 74.5 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DNA_pol_E_B PF04042.16 AMD20391.1 - 3.3e-52 176.9 0.4 5e-52 176.3 0.4 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Imm10 PF15588.6 AMD20391.1 - 0.033 14.3 0.2 0.078 13.1 0.2 1.6 1 0 0 1 1 1 0 Immunity protein 10 DNA_pol_D_N PF18018.1 AMD20391.1 - 0.13 12.3 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain Prenyltrans PF00432.21 AMD20392.1 - 1.3e-61 203.9 6.1 4.6e-12 45.4 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 AMD20392.1 - 3.1e-06 26.5 0.0 0.0002 20.6 0.0 3.2 1 1 4 5 5 5 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 AMD20392.1 - 0.00018 20.7 0.0 2.5 7.1 0.0 4.1 1 1 4 5 5 5 3 Squalene-hopene cyclase N-terminal domain TED_complement PF07678.14 AMD20392.1 - 0.0059 15.7 0.0 0.11 11.5 0.0 2.8 3 1 1 4 4 4 1 A-macroglobulin TED domain WD40 PF00400.32 AMD20393.1 - 1.4e-41 139.7 15.6 1.9e-09 38.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20393.1 - 4.3e-17 62.2 0.5 0.0055 17.0 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD20393.1 - 1.6e-07 31.4 0.0 0.023 14.6 0.0 3.8 1 1 4 5 5 5 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 AMD20393.1 - 0.00045 19.6 0.0 0.0019 17.6 0.0 1.9 2 0 0 2 2 2 1 WD40-like domain Cytochrom_D1 PF02239.16 AMD20393.1 - 0.0012 17.5 0.2 0.039 12.5 0.0 2.4 2 1 0 2 2 2 1 Cytochrome D1 heme domain Nbas_N PF15492.6 AMD20393.1 - 0.0029 17.0 0.1 1.6 8.0 0.0 3.1 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 AMD20393.1 - 0.0032 16.5 0.1 0.18 10.7 0.0 3.4 2 1 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Pox_RNA_Pol_19 PF05320.12 AMD20393.1 - 0.014 15.4 0.2 0.026 14.5 0.2 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit HDA2-3 PF11496.8 AMD20394.1 - 5.5e-94 314.6 2.0 5.5e-94 314.6 2.0 2.2 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 CALCOCO1 PF07888.11 AMD20394.1 - 0.0021 17.0 25.7 0.0033 16.3 25.7 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like MscS_porin PF12795.7 AMD20394.1 - 0.0044 16.6 28.9 0.45 10.0 17.6 3.0 1 1 1 2 2 2 2 Mechanosensitive ion channel porin domain DUF4201 PF13870.6 AMD20394.1 - 0.0067 16.2 4.2 0.0067 16.2 4.2 3.1 3 1 1 4 4 4 1 Domain of unknown function (DUF4201) CEP63 PF17045.5 AMD20394.1 - 0.021 14.7 22.2 0.02 14.8 10.6 2.3 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa Spc7 PF08317.11 AMD20394.1 - 0.048 12.6 31.1 0.053 12.4 17.8 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein IFT57 PF10498.9 AMD20394.1 - 0.23 10.4 24.3 0.096 11.6 10.9 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 FAM76 PF16046.5 AMD20394.1 - 0.25 10.7 14.0 0.49 9.7 14.0 1.5 1 0 0 1 1 1 0 FAM76 protein Sec8_exocyst PF04048.14 AMD20394.1 - 0.48 10.3 15.9 0.49 10.3 3.4 3.6 1 1 3 4 4 4 0 Sec8 exocyst complex component specific domain Fez1 PF06818.15 AMD20394.1 - 0.8 10.1 30.3 4.1 7.8 25.6 2.6 2 1 0 2 2 2 0 Fez1 Phage_GPO PF05929.11 AMD20394.1 - 1.9 8.0 15.1 0.64 9.6 8.4 2.2 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3813 PF12758.7 AMD20394.1 - 2.5 8.5 8.5 0.2 12.0 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) CHD5 PF04420.14 AMD20394.1 - 3.7 7.4 5.8 10 6.0 5.8 1.8 1 0 0 1 1 1 0 CHD5-like protein Cluap1 PF10234.9 AMD20394.1 - 7.6 5.9 21.7 45 3.3 21.6 2.2 1 1 1 2 2 2 0 Clusterin-associated protein-1 FUSC PF04632.12 AMD20394.1 - 8.2 4.8 6.4 12 4.3 6.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family ThiF PF00899.21 AMD20395.1 - 7.6e-26 91.0 0.0 9.1e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Sec23_trunk PF04811.15 AMD20396.1 - 4.1e-72 242.7 0.0 5.5e-72 242.2 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 AMD20396.1 - 2.8e-28 98.5 0.0 5.5e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 AMD20396.1 - 2e-27 95.0 0.2 5.4e-27 93.6 0.2 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AMD20396.1 - 3.4e-14 52.6 3.2 7.4e-14 51.5 3.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AMD20396.1 - 3.5e-11 42.8 0.0 6.8e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 AMD20396.1 - 0.053 12.9 0.1 0.13 11.7 0.1 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-MIZ PF02891.20 AMD20396.1 - 0.09 12.5 0.9 0.2 11.4 0.9 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Tagatose_6_P_K PF08013.11 AMD20396.1 - 0.094 11.4 0.1 0.18 10.5 0.1 1.3 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase MHC_I PF00129.18 AMD20396.1 - 0.18 11.3 0.0 0.61 9.6 0.0 1.8 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 PIG-U PF06728.13 AMD20397.1 - 1.3e-100 337.1 42.8 1.8e-100 336.7 42.8 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U DUF2645 PF10840.8 AMD20397.1 - 0.018 15.7 1.0 0.018 15.7 1.0 4.1 4 1 0 4 4 4 0 Protein of unknown function (DUF2645) LSM PF01423.22 AMD20398.1 - 7.5e-19 67.2 0.3 8.7e-19 67.0 0.3 1.1 1 0 0 1 1 1 1 LSM domain Glycos_transf_2 PF00535.26 AMD20399.1 - 2.7e-29 102.2 0.0 3.7e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AMD20399.1 - 2.8e-07 30.7 0.0 4.6e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 AMD20399.1 - 0.0027 17.2 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 hDGE_amylase PF14701.6 AMD20400.1 - 2.6e-161 537.6 0.1 3.4e-161 537.2 0.1 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 AMD20400.1 - 5.2e-115 384.4 0.0 7.1e-115 384.0 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 AMD20400.1 - 4.4e-63 213.3 0.0 9.9e-63 212.1 0.0 1.6 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 AMD20400.1 - 1.1e-17 63.9 0.6 3.3e-17 62.4 0.1 2.1 2 0 0 2 2 2 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 AMD20400.1 - 9.7e-06 25.4 0.8 9e-05 22.2 0.0 2.4 3 0 0 3 3 3 1 Alpha amylase, catalytic domain ATG13 PF10033.9 AMD20401.1 - 7.8e-69 232.0 0.2 1.7e-68 230.9 0.2 1.6 1 0 0 1 1 1 1 Autophagy-related protein 13 OPT PF03169.15 AMD20402.1 - 1.1e-159 533.0 50.8 1.2e-159 532.8 50.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PWWP PF00855.17 AMD20405.1 - 2.6e-16 59.8 0.9 1.2e-15 57.7 0.1 2.2 2 0 0 2 2 2 1 PWWP domain CAML PF14963.6 AMD20405.1 - 0.0033 17.6 4.0 0.0044 17.2 4.0 1.2 1 0 0 1 1 1 1 Calcium signal-modulating cyclophilin ligand Sec10 PF07393.11 AMD20405.1 - 0.0061 15.0 2.8 0.0085 14.6 2.8 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec10 AAR2 PF05282.11 AMD20405.1 - 0.06 12.8 4.0 0.039 13.4 1.7 1.7 2 0 0 2 2 2 0 AAR2 protein DUF4674 PF15719.5 AMD20405.1 - 0.29 11.1 7.3 0.52 10.3 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Putative_PNPOx PF01243.20 AMD20406.1 - 7.8e-14 51.6 0.0 1.6e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.6 AMD20406.1 - 0.00017 21.6 0.2 0.00034 20.6 0.2 1.4 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Nrap_D2 PF17403.2 AMD20406.1 - 0.024 14.4 0.6 4.1 7.2 0.0 2.1 1 1 1 2 2 2 0 Nrap protein PAP/OAS-like domain AAA PF00004.29 AMD20407.1 - 1.8e-43 148.1 0.0 3.9e-43 147.0 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 AMD20407.1 - 4.7e-29 100.2 0.7 1.9e-28 98.2 0.2 2.3 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 AMD20407.1 - 2.8e-22 78.5 4.4 6.9e-22 77.3 4.4 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 AMD20407.1 - 6.9e-08 32.2 0.0 2.7e-07 30.3 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AMD20407.1 - 1.6e-06 28.6 0.4 0.00013 22.4 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AMD20407.1 - 8.2e-06 25.7 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AMD20407.1 - 8.7e-06 26.1 0.0 0.00091 19.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AMD20407.1 - 2.2e-05 24.5 0.0 8.9e-05 22.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 AMD20407.1 - 5.4e-05 23.0 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 AMD20407.1 - 5.6e-05 22.5 0.0 0.0001 21.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 AMD20407.1 - 0.0001 22.4 0.0 0.00034 20.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.13 AMD20407.1 - 0.00013 21.3 0.0 0.0005 19.3 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 AMD20407.1 - 0.00017 21.9 0.4 0.009 16.4 0.0 3.1 4 0 0 4 4 2 1 RNA helicase AAA_18 PF13238.6 AMD20407.1 - 0.00085 19.9 0.0 0.0022 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 AMD20407.1 - 0.0011 19.1 0.1 0.0042 17.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 AMD20407.1 - 0.0019 18.3 0.0 0.0053 16.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 AMD20407.1 - 0.0034 17.1 0.0 0.0085 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 AMD20407.1 - 0.0052 16.4 0.1 0.24 11.0 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AMD20407.1 - 0.01 16.3 0.0 0.034 14.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain ATPase PF06745.13 AMD20407.1 - 0.015 14.6 0.0 5.4 6.3 0.0 2.3 1 1 1 2 2 2 0 KaiC Torsin PF06309.11 AMD20407.1 - 0.023 14.8 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 Torsin AAA_7 PF12775.7 AMD20407.1 - 0.027 14.0 0.0 0.078 12.5 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AMD20407.1 - 0.029 13.8 0.0 0.082 12.3 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Use1 PF09753.9 AMD20407.1 - 0.049 13.3 1.1 0.097 12.4 1.1 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 Zeta_toxin PF06414.12 AMD20407.1 - 0.076 12.3 0.2 1.1 8.5 0.1 2.5 1 1 2 3 3 3 0 Zeta toxin PhoH PF02562.16 AMD20407.1 - 0.076 12.5 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 AMD20407.1 - 0.08 12.8 0.1 2.5 7.9 0.0 2.5 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 AMD20407.1 - 0.088 12.5 0.0 0.27 10.9 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 AMD20407.1 - 0.097 11.8 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.12 AMD20407.1 - 0.12 12.2 0.4 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NACHT PF05729.12 AMD20407.1 - 0.13 12.2 0.0 0.75 9.7 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Sigma54_activ_2 PF14532.6 AMD20407.1 - 0.14 12.3 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain NBP1 PF08537.10 AMD20408.1 - 3.6e-100 335.7 26.1 4.1e-100 335.5 26.1 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 Snurportin1 PF11538.8 AMD20408.1 - 1.6 9.0 6.8 0.15 12.2 0.7 2.5 2 0 0 2 2 2 0 Snurportin1 Peptidase_S10 PF00450.22 AMD20409.1 - 2.1e-105 353.6 0.0 2.6e-105 353.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase PAPS_reduct PF01507.19 AMD20410.1 - 5.3e-34 117.7 0.0 7e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family MerR PF00376.23 AMD20410.1 - 0.092 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 MerR family regulatory protein Med10 PF09748.9 AMD20411.1 - 1.8e-38 131.2 0.2 2.1e-38 131.0 0.2 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex ANAPC4_WD40 PF12894.7 AMD20412.1 - 3.5e-05 24.0 0.6 0.24 11.7 0.0 4.5 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD20412.1 - 0.00041 21.1 0.7 4 8.5 0.1 5.5 6 0 0 6 6 6 1 WD domain, G-beta repeat BUD22 PF09073.10 AMD20412.1 - 3.3 7.0 18.8 6.3 6.0 0.0 2.1 2 0 0 2 2 2 0 BUD22 OPT PF03169.15 AMD20413.1 - 5.1e-173 577.0 59.2 5.8e-173 576.8 59.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein SNAP PF14938.6 AMD20414.1 - 5.1e-102 341.1 15.2 5.8e-102 340.9 15.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 AMD20414.1 - 0.0049 16.9 9.9 7.5 6.9 0.3 6.1 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 AMD20414.1 - 0.0075 16.8 7.4 3.5 8.5 0.1 5.7 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20414.1 - 0.013 16.0 13.9 0.43 11.1 0.8 3.9 2 2 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD20414.1 - 0.033 14.4 9.6 0.2 11.9 1.2 3.8 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 AMD20414.1 - 0.043 14.1 11.0 0.17 12.2 0.1 4.0 1 1 3 4 4 4 0 Tetratricopeptide repeat FerI PF08151.12 AMD20414.1 - 0.087 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 FerI (NUC094) domain FRB_dom PF08771.11 AMD20414.1 - 0.12 12.8 1.1 0.24 11.8 0.0 2.0 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain NSF PF02071.20 AMD20414.1 - 0.3 12.0 12.6 10 7.4 0.1 6.7 8 0 0 8 8 8 0 Aromatic-di-Alanine (AdAR) repeat NAD_binding_6 PF08030.12 AMD20415.1 - 1.4e-20 74.0 0.0 2.8e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 AMD20415.1 - 2.8e-20 72.4 0.1 5.3e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 AMD20415.1 - 2.6e-17 63.1 17.1 2.6e-17 63.1 17.1 2.8 3 0 0 3 3 3 1 Ferric reductase like transmembrane component CENP-B_dimeris PF09026.10 AMD20415.1 - 0.12 12.7 3.7 0.29 11.5 3.7 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Yippee-Mis18 PF03226.14 AMD20416.1 - 3.2e-14 53.0 5.1 3.8e-14 52.8 5.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly NOB1_Zn_bind PF08772.11 AMD20416.1 - 0.61 10.3 6.6 0.12 12.5 1.3 2.1 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Myotub-related PF06602.14 AMD20417.1 - 1.5e-141 471.4 2.5 2.2e-141 470.9 2.5 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 AMD20417.1 - 0.0026 17.6 0.0 0.0069 16.3 0.0 1.7 1 0 0 1 1 1 1 GRAM domain Y_phosphatase PF00102.27 AMD20417.1 - 0.017 14.7 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase HTH_29 PF13551.6 AMD20417.1 - 0.062 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix DSPc PF00782.20 AMD20417.1 - 0.086 12.6 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AMD20417.1 - 0.094 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Proteasom_PSMB PF10508.9 AMD20418.1 - 0.0072 14.9 0.0 0.012 14.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit CMD PF02627.20 AMD20418.1 - 0.0091 16.0 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Nnf1 PF03980.14 AMD20419.1 - 1.7e-27 95.9 1.9 3.2e-27 95.1 1.4 1.7 1 1 0 1 1 1 1 Nnf1 FapA PF03961.13 AMD20419.1 - 0.0017 17.0 3.8 0.0025 16.5 3.8 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF1640 PF07798.11 AMD20419.1 - 0.018 15.1 0.6 0.033 14.3 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Baculo_PEP_C PF04513.12 AMD20419.1 - 0.045 13.8 2.9 0.047 13.7 1.4 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CLZ PF16526.5 AMD20419.1 - 0.048 14.0 1.1 0.048 14.0 1.1 2.4 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels RasGAP_C PF03836.15 AMD20419.1 - 0.082 13.1 2.8 0.74 10.0 2.8 2.3 1 1 0 1 1 1 0 RasGAP C-terminus Trimer_CC PF08954.11 AMD20419.1 - 0.09 12.4 0.4 0.09 12.4 0.4 2.0 2 0 0 2 2 2 0 Trimerisation motif TcdB_N PF12918.7 AMD20419.1 - 0.1 12.9 6.4 4 7.8 0.1 3.1 2 1 0 2 2 2 0 TcdB toxin N-terminal helical domain Mt_ATP-synt_D PF05873.12 AMD20419.1 - 0.18 11.7 1.1 0.4 10.5 0.1 2.0 2 1 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF1664 PF07889.12 AMD20419.1 - 0.25 11.4 1.6 0.36 10.9 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin PF02996.17 AMD20419.1 - 1.2 9.0 7.1 0.2 11.6 1.6 2.4 3 0 0 3 3 3 0 Prefoldin subunit MbeB_N PF04837.12 AMD20419.1 - 1.2 9.5 5.6 0.82 10.0 0.6 2.7 3 0 0 3 3 2 0 MbeB-like, N-term conserved region DUF4404 PF14357.6 AMD20419.1 - 2.4 8.9 6.8 0.81 10.4 2.8 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) bZIP_1 PF00170.21 AMD20419.1 - 2.7 8.1 14.2 0.18 11.9 6.8 2.7 3 0 0 3 3 3 0 bZIP transcription factor FlaC_arch PF05377.11 AMD20419.1 - 3.3 8.2 8.7 0.32 11.4 1.8 2.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) EF-hand_4 PF12763.7 AMD20420.1 - 2.4e-30 104.5 0.0 6.8e-10 38.8 0.0 3.8 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 AMD20420.1 - 8.1e-09 35.2 0.1 1.5e-08 34.4 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_7 PF13499.6 AMD20420.1 - 5.3e-08 33.2 0.3 1.6 9.2 0.0 5.1 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_1 PF00036.32 AMD20420.1 - 1.2e-07 30.8 0.2 0.03 13.9 0.0 4.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 AMD20420.1 - 4.3e-07 29.3 5.1 0.05 13.6 0.0 5.5 5 0 0 5 5 5 1 EF-hand domain UBA_4 PF14555.6 AMD20420.1 - 0.0048 16.7 0.9 0.012 15.4 0.9 1.7 1 0 0 1 1 1 1 UBA-like domain EF-hand_8 PF13833.6 AMD20420.1 - 0.021 14.6 0.1 9.2 6.2 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_5 PF13202.6 AMD20420.1 - 0.29 10.7 2.6 10 5.8 0.0 3.9 4 0 0 4 4 4 0 EF hand LPP PF04728.13 AMD20420.1 - 0.87 10.0 5.3 0.22 11.9 0.7 2.5 2 0 0 2 2 2 0 Lipoprotein leucine-zipper VanZ PF04892.12 AMD20421.1 - 1.3e-06 29.1 0.2 2.2e-06 28.4 0.2 1.4 1 1 0 1 1 1 1 VanZ like family Ribosomal_S7 PF00177.21 AMD20422.1 - 2e-34 118.4 0.4 3.9e-34 117.4 0.2 1.5 1 1 1 2 2 2 1 Ribosomal protein S7p/S5e PPP4R2 PF09184.11 AMD20423.1 - 1.4e-47 162.7 3.2 1.4e-47 162.7 3.2 2.1 1 1 1 2 2 2 1 PPP4R2 Nop14 PF04147.12 AMD20423.1 - 3.3 5.8 16.7 3.8 5.6 16.7 1.2 1 0 0 1 1 1 0 Nop14-like family Peptidase_M16_C PF05193.21 AMD20424.1 - 1.1e-20 74.4 0.0 2.3e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AMD20424.1 - 4.9e-20 72.0 0.6 9.4e-20 71.1 0.6 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) HOOK PF05622.12 AMD20424.1 - 0.024 12.8 0.1 0.035 12.3 0.1 1.1 1 0 0 1 1 1 0 HOOK protein MKT1_C PF12246.8 AMD20425.1 - 0.062 12.5 0.0 0.098 11.9 0.0 1.3 1 1 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication Peptidase_M20 PF01546.28 AMD20426.1 - 7.2e-25 87.9 0.0 1.2e-24 87.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AMD20426.1 - 2.6e-11 43.4 0.0 4.6e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 AMD20426.1 - 0.048 13.3 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Proteasome PF00227.26 AMD20427.1 - 2.1e-37 128.4 0.1 2e-36 125.3 0.1 1.9 1 1 0 1 1 1 1 Proteasome subunit Phage_Coat_B PF05356.11 AMD20427.1 - 0.02 14.8 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Phage Coat protein B ER_lumen_recept PF00810.18 AMD20428.1 - 4.3e-47 160.6 13.9 4.3e-47 160.6 13.9 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor Sdh_cyt PF01127.22 AMD20428.1 - 0.022 14.8 2.6 0.026 14.5 0.7 2.1 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit LRR_2 PF07723.13 AMD20428.1 - 0.18 12.5 0.2 0.46 11.2 0.2 1.8 1 0 0 1 1 1 0 Leucine Rich Repeat DUF441 PF04284.13 AMD20428.1 - 0.65 10.0 5.4 0.17 11.9 1.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF441) Sod_Cu PF00080.20 AMD20430.1 - 2.6e-49 167.0 2.9 3.1e-49 166.8 2.9 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CTP_synth_N PF06418.14 AMD20431.1 - 1.3e-121 405.0 0.1 1.8e-121 404.5 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 AMD20431.1 - 1.9e-58 197.4 0.0 3e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AMD20431.1 - 0.005 16.6 0.2 0.038 13.7 0.1 2.3 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 AMD20431.1 - 0.081 13.0 0.0 0.17 12.0 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ESCRT-II PF05871.12 AMD20433.1 - 2.4e-38 131.6 0.1 3.7e-38 130.9 0.1 1.3 2 0 0 2 2 2 1 ESCRT-II complex subunit Sod_Fe_C PF02777.18 AMD20434.1 - 2.9e-17 62.7 2.6 2.8e-15 56.4 2.6 2.3 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Peptidase_C12 PF01088.21 AMD20435.1 - 9.8e-51 172.5 0.0 1.4e-50 172.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 AMD20435.1 - 0.00043 20.1 2.5 0.00086 19.2 2.5 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases SAC3_GANP PF03399.16 AMD20436.1 - 4.5e-21 75.5 11.5 5.7e-19 68.6 11.5 2.3 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 AMD20436.1 - 0.011 15.7 4.0 0.023 14.7 4.0 1.5 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family Peptidase_C12 PF01088.21 AMD20437.1 - 5.8e-46 156.9 0.0 7.1e-46 156.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 PX PF00787.24 AMD20438.1 - 0.00018 21.5 0.0 0.00036 20.5 0.0 1.4 1 0 0 1 1 1 1 PX domain Aldo_ket_red PF00248.21 AMD20439.1 - 4.5e-47 160.7 0.1 3.8e-34 118.2 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Mito_carr PF00153.27 AMD20441.1 - 1.6e-66 220.3 2.0 3.2e-23 81.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ysc84 PF04366.12 AMD20441.1 - 0.042 13.6 0.4 0.073 12.8 0.4 1.5 1 0 0 1 1 1 0 Las17-binding protein actin regulator Ribosomal_L37ae PF01780.19 AMD20442.1 - 7.4e-40 134.9 9.0 8.3e-40 134.8 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Rep_fac-A_C PF08646.10 AMD20442.1 - 0.0064 16.3 0.3 0.0073 16.1 0.3 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain zf-RING_13 PF17977.1 AMD20442.1 - 0.008 16.3 3.0 0.011 15.8 3.0 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain C1_2 PF03107.16 AMD20442.1 - 0.025 14.9 2.5 2.3 8.6 0.1 2.1 1 1 1 2 2 2 0 C1 domain Zn_Tnp_IS1595 PF12760.7 AMD20442.1 - 0.032 14.2 2.8 0.058 13.4 2.8 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF2175 PF09943.9 AMD20442.1 - 0.1 12.9 0.4 6.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-H2C2_2 PF13465.6 AMD20442.1 - 0.1 13.0 0.8 2.2 8.8 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-C4_ClpX PF06689.13 AMD20442.1 - 0.15 12.0 2.4 0.24 11.3 0.2 2.2 2 0 0 2 2 2 0 ClpX C4-type zinc finger CarbpepA_inh PF02977.15 AMD20442.1 - 0.21 11.4 3.7 1.9 8.4 3.7 2.1 1 1 0 1 1 1 0 Carboxypeptidase A inhibitor Beta-TrCP_D PF12125.8 AMD20443.1 - 0.02 14.7 0.0 0.05 13.5 0.0 1.6 1 0 0 1 1 1 0 D domain of beta-TrCP Fip1 PF05182.13 AMD20444.1 - 1.3e-22 79.0 0.4 2.2e-22 78.3 0.4 1.4 1 0 0 1 1 1 1 Fip1 motif TFIIF_alpha PF05793.12 AMD20444.1 - 0.1 11.2 11.4 0.18 10.4 11.4 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FSA_C PF10479.9 AMD20444.1 - 0.18 9.9 7.1 0.26 9.4 7.1 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ecl1 PF12855.7 AMD20444.1 - 2.6 9.2 8.0 4.5 8.4 8.0 1.3 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins PH PF00169.29 AMD20445.1 - 0.00055 20.4 2.8 0.0014 19.1 0.1 3.1 4 0 0 4 4 4 1 PH domain PUF PF00806.19 AMD20446.1 - 2.2e-29 99.5 1.6 0.00013 21.5 0.0 6.8 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat RRM_1 PF00076.22 AMD20446.1 - 0.00011 22.0 0.0 0.00026 20.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MAM1 PF10434.9 AMD20447.1 - 9.3e-53 179.5 10.4 1.8e-52 178.6 10.4 1.3 1 0 0 1 1 1 1 Monopolin complex protein MAM1 Pfg27 PF09216.10 AMD20447.1 - 0.0075 16.1 1.0 0.017 14.9 1.0 1.5 1 0 0 1 1 1 1 Pfg27 GatB_N PF02934.15 AMD20448.1 - 1.7e-94 316.3 0.1 2.3e-94 315.8 0.1 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AMD20448.1 - 9.5e-26 90.5 0.1 1.9e-25 89.5 0.1 1.4 1 0 0 1 1 1 1 GatB domain DUF5349 PF17298.2 AMD20449.1 - 3.6e-28 99.4 49.7 9.4e-27 94.7 49.7 2.1 1 1 0 1 1 1 1 Family of unknown function (DUF5349) WD40 PF00400.32 AMD20450.1 - 4.8e-20 71.5 6.8 4e-05 24.3 0.4 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20450.1 - 5.2e-08 33.1 0.0 0.03 14.6 0.0 4.4 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD20450.1 - 9.3e-05 21.3 0.3 0.056 12.1 0.1 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AMD20450.1 - 0.0057 15.6 0.2 0.019 14.0 0.1 2.0 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 AMD20450.1 - 0.0095 14.3 0.0 0.33 9.2 0.0 2.0 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz LisH PF08513.11 AMD20451.1 - 6.9e-07 29.0 0.4 1.3e-06 28.1 0.4 1.5 1 0 0 1 1 1 1 LisH ALG3 PF05208.13 AMD20452.1 - 3.3e-128 428.1 26.1 4e-128 427.8 26.1 1.0 1 0 0 1 1 1 1 ALG3 protein HEAT_EZ PF13513.6 AMD20453.1 - 2e-18 66.5 0.0 0.00077 19.9 0.0 7.6 8 0 0 8 8 8 4 HEAT-like repeat IBN_N PF03810.19 AMD20453.1 - 2.8e-11 43.1 4.1 5.4e-09 35.8 0.0 3.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.22 AMD20453.1 - 2.5e-10 39.7 1.5 1.1 9.7 0.0 7.3 8 0 0 8 8 7 3 HEAT repeat HEAT_2 PF13646.6 AMD20453.1 - 2.9e-10 40.4 0.1 0.051 14.0 0.0 5.8 5 0 0 5 5 5 3 HEAT repeats Cnd1 PF12717.7 AMD20453.1 - 6.2e-07 29.6 7.5 0.017 15.2 0.4 5.6 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 AMD20453.1 - 6.6e-07 29.4 0.3 7.4 6.5 0.0 6.0 5 2 1 6 6 6 2 Domain of unknown function (DUF3385) CLASP_N PF12348.8 AMD20453.1 - 2.6e-06 27.2 0.1 2.6 7.6 0.0 4.3 4 0 0 4 4 4 3 CLASP N terminal Vac14_Fab1_bd PF12755.7 AMD20453.1 - 3e-05 24.5 6.5 1.9 9.1 0.0 6.5 7 1 1 8 8 8 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 AMD20453.1 - 0.00098 18.9 1.2 1.1 9.0 0.3 4.3 3 1 0 4 4 4 1 rRNA processing/ribosome biogenesis Tti2 PF10521.9 AMD20453.1 - 0.032 13.8 0.6 0.51 9.8 0.0 3.0 2 1 1 3 3 3 0 Tti2 family LRR_RI_capping PF18779.1 AMD20453.1 - 0.039 13.6 0.1 0.14 11.9 0.1 1.9 1 0 0 1 1 1 0 Capping Ribonuclease inhibitor Leucine Rich Repeat PAD_M PF08527.10 AMD20453.1 - 0.062 13.0 0.3 0.27 10.9 0.1 2.0 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain KilA-N PF04383.13 AMD20454.1 - 1.5e-07 31.2 0.6 1.2e-06 28.4 0.6 2.5 1 1 0 1 1 1 1 KilA-N domain Ank_4 PF13637.6 AMD20454.1 - 1.7e-07 31.7 4.6 0.0095 16.5 0.2 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AMD20454.1 - 4.5e-07 30.4 1.7 0.017 15.7 0.3 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AMD20454.1 - 0.00036 20.8 1.7 0.025 14.9 0.1 3.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD20454.1 - 0.0011 19.2 2.7 1.7 9.5 0.1 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 AMD20454.1 - 0.0037 17.7 2.1 2 9.0 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat LSM PF01423.22 AMD20455.1 - 7e-17 60.9 0.1 1e-16 60.4 0.1 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AMD20455.1 - 0.00033 20.7 0.0 0.00052 20.1 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain EMP70 PF02990.16 AMD20456.1 - 3.4e-86 290.0 12.6 5e-86 289.4 12.6 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 TPR_2 PF07719.17 AMD20457.1 - 5.7e-45 147.8 12.1 1.7e-07 30.8 0.1 10.4 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.28 AMD20457.1 - 1.5e-37 125.9 20.3 4.3e-08 32.6 0.1 9.5 9 0 0 9 9 9 6 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD20457.1 - 5.9e-36 122.6 25.7 1.5e-22 79.6 4.3 4.7 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AMD20457.1 - 1.7e-32 108.9 12.7 7e-05 22.7 0.4 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.6 AMD20457.1 - 2.3e-25 88.0 14.2 1.4e-05 24.7 0.1 7.8 3 1 5 8 8 8 5 TPR repeat TPR_14 PF13428.6 AMD20457.1 - 3.5e-22 77.2 1.1 0.0034 18.1 0.0 8.8 4 3 4 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 AMD20457.1 - 4.4e-21 75.3 0.4 4.4e-05 24.0 0.0 5.9 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 AMD20457.1 - 6.3e-21 74.5 13.1 0.00018 21.7 0.4 8.4 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20457.1 - 1.8e-18 66.8 4.9 5.2e-05 23.7 0.0 5.9 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 AMD20457.1 - 1.9e-16 59.2 31.4 7.2e-05 22.9 0.4 9.1 10 0 0 10 10 8 5 Tetratricopeptide repeat TPR_6 PF13174.6 AMD20457.1 - 4.6e-14 52.0 18.5 0.077 13.7 0.0 9.7 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_7 PF13176.6 AMD20457.1 - 1.2e-12 46.9 9.2 0.82 9.8 0.1 8.7 8 2 1 9 9 9 3 Tetratricopeptide repeat TPR_15 PF13429.6 AMD20457.1 - 2.4e-11 43.4 3.7 0.00048 19.4 0.0 5.0 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 AMD20457.1 - 2.3e-06 27.6 0.1 0.038 14.1 0.0 4.2 3 2 2 5 5 5 1 Tetratricopeptide repeat DUF3856 PF12968.7 AMD20457.1 - 9.5e-05 22.5 0.6 0.66 10.0 0.1 5.3 4 1 1 5 5 4 1 Domain of Unknown Function (DUF3856) TPR_10 PF13374.6 AMD20457.1 - 0.00015 21.5 6.2 13 5.8 0.0 8.1 10 1 0 10 10 9 0 Tetratricopeptide repeat TPR_4 PF07721.14 AMD20457.1 - 0.00022 21.5 0.3 4.6 8.2 0.0 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 AMD20457.1 - 0.001 19.4 0.3 19 5.6 0.0 4.9 3 2 2 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.17 AMD20457.1 - 0.0011 19.4 0.0 0.71 10.3 0.0 2.8 2 1 1 3 3 2 1 Bacterial transcriptional activator domain TPR_3 PF07720.12 AMD20457.1 - 0.0025 17.8 14.3 0.3 11.1 2.2 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.9 AMD20457.1 - 0.012 15.3 0.2 1.2 8.8 0.2 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain HrpB1_HrpK PF09613.10 AMD20457.1 - 0.036 13.7 0.0 45 3.7 0.0 3.7 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) SRP_TPR_like PF17004.5 AMD20457.1 - 0.098 12.7 10.5 0.16 12.0 0.0 4.0 4 1 0 4 4 4 0 Putative TPR-like repeat IlvGEDA_leader PF08046.11 AMD20457.1 - 0.34 10.4 0.9 0.67 9.4 0.9 1.5 1 0 0 1 1 1 0 IlvGEDA operon leader peptide Fis1_TPR_C PF14853.6 AMD20457.1 - 0.38 10.9 17.0 3 8.0 0.7 6.3 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 AMD20457.1 - 2.2 8.7 8.1 28 5.3 0.0 4.6 5 0 0 5 5 4 0 PPR repeat TFIIA PF03153.13 AMD20457.1 - 3.9 7.4 11.8 5.3 6.9 11.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NST1 PF13945.6 AMD20457.1 - 5.4 7.1 15.4 11 6.1 15.4 1.6 1 0 0 1 1 1 0 Salt tolerance down-regulator PH PF00169.29 AMD20458.1 - 3.4e-17 62.9 0.1 1.9e-16 60.4 0.0 2.3 2 0 0 2 2 2 1 PH domain SH3_1 PF00018.28 AMD20458.1 - 4.2e-13 48.7 0.2 9.7e-13 47.5 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 AMD20458.1 - 5.7e-13 48.8 0.0 9.9e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 AMD20458.1 - 4.8e-09 35.9 0.1 9.5e-09 35.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 AMD20458.1 - 6.5e-08 32.9 0.0 1.2e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 AMD20458.1 - 0.002 18.3 0.0 0.1 12.9 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 AMD20458.1 - 0.011 16.1 0.4 0.27 11.7 0.4 2.9 1 1 0 1 1 1 0 Pleckstrin homology domain SH3_2 PF07653.17 AMD20458.1 - 0.012 15.3 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain BORCS8 PF10167.9 AMD20458.1 - 0.087 12.8 0.9 0.36 10.8 0.1 2.5 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 8 Mut7-C PF01927.16 AMD20458.1 - 0.19 11.8 0.0 22 5.2 0.0 2.5 2 0 0 2 2 2 0 Mut7-C RNAse domain NT-C2 PF10358.9 AMD20459.1 - 1.3e-40 138.5 0.0 2e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins zf-C3HC4 PF00097.25 AMD20461.1 - 8e-11 41.6 4.3 1.3e-10 40.9 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD20461.1 - 1.2e-09 37.9 4.2 2.1e-09 37.1 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD20461.1 - 6.8e-09 35.6 3.7 1.3e-08 34.7 3.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AMD20461.1 - 9.3e-08 31.9 5.3 1.6e-07 31.1 5.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AMD20461.1 - 4.2e-07 30.2 5.6 7.3e-07 29.4 5.6 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 AMD20461.1 - 4.8e-06 26.3 4.0 1.6e-05 24.7 4.2 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 AMD20461.1 - 6.8e-06 25.8 6.8 1.9e-05 24.4 7.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AMD20461.1 - 0.0027 17.7 1.7 0.0041 17.1 1.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 AMD20461.1 - 0.0063 16.6 6.5 0.0063 16.6 6.5 2.0 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 AMD20461.1 - 0.014 15.2 4.7 0.43 10.4 0.4 3.4 3 1 0 3 3 3 0 RING-like zinc finger FBP_C PF16571.5 AMD20461.1 - 0.02 14.4 1.0 0.044 13.3 0.4 1.9 1 1 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger zf-RING_4 PF14570.6 AMD20461.1 - 0.04 13.7 5.3 0.14 12.0 5.3 1.9 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 AMD20461.1 - 0.14 12.5 3.6 0.39 11.0 3.6 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-Di19 PF05605.12 AMD20461.1 - 0.48 10.8 4.9 1.1 9.6 0.2 2.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ribosomal_L14 PF00238.19 AMD20462.1 - 2.6e-33 114.7 0.0 3.1e-33 114.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e PI3_PI4_kinase PF00454.27 AMD20463.1 - 4.6e-55 187.1 0.0 9.1e-55 186.2 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 AMD20463.1 - 4e-27 95.2 3.8 4e-27 95.2 3.8 4.1 5 0 0 5 5 5 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 AMD20463.1 - 1.8e-11 43.7 0.1 6.2e-11 41.9 0.0 2.1 2 0 0 2 2 2 1 FATC domain SpoVIF PF14069.6 AMD20463.1 - 0.1 12.4 0.2 1 9.2 0.2 2.9 1 0 0 1 1 1 0 Stage VI sporulation protein F SH3_9 PF14604.6 AMD20464.1 - 6.6e-10 38.7 0.0 1.1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AMD20464.1 - 1.2e-09 37.6 0.1 2.6e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AMD20464.1 - 1.1e-07 31.5 0.0 2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain 7TMR-DISM_7TM PF07695.11 AMD20464.1 - 0.0023 17.8 7.1 0.0032 17.4 7.1 1.1 1 0 0 1 1 1 1 7TM diverse intracellular signalling DUF2070 PF09843.9 AMD20464.1 - 5.2 5.2 8.0 7.1 4.8 8.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Aa_trans PF01490.18 AMD20465.1 - 2.1e-101 339.6 25.7 2.7e-101 339.3 25.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ribosomal_S21 PF01165.20 AMD20466.1 - 3.8e-12 45.7 2.7 6e-12 45.1 2.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 Peptidase_M24 PF00557.24 AMD20467.1 - 1.1e-51 175.5 0.3 1.4e-51 175.2 0.3 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Motile_Sperm PF00635.26 AMD20468.1 - 3.6e-26 91.2 0.3 9.1e-26 89.9 0.1 1.7 1 1 1 2 2 2 1 MSP (Major sperm protein) domain TMEM131_like PF12371.8 AMD20468.1 - 0.00033 20.8 0.1 0.00061 20.0 0.1 1.4 1 0 0 1 1 1 1 Transmembrane protein 131-like ASH PF15780.5 AMD20468.1 - 0.067 13.4 1.1 0.11 12.7 0.1 1.7 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF4693 PF15764.5 AMD20468.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4693) Ribosomal_L32e PF01655.18 AMD20469.1 - 1.8e-47 160.2 1.9 2.1e-47 160.0 1.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Rox3 PF08633.10 AMD20470.1 - 1.3e-38 133.4 0.4 1.9e-38 132.8 0.4 1.2 1 0 0 1 1 1 1 Rox3 mediator complex subunit ArfGap PF01412.18 AMD20471.1 - 3e-34 117.6 0.6 6.1e-34 116.6 0.2 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf GATase PF00117.28 AMD20471.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase class-I 4HBT PF03061.22 AMD20472.1 - 1.1e-05 25.7 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily FAD_binding_3 PF01494.19 AMD20473.1 - 2.9e-18 66.3 0.0 5e-18 65.5 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 AMD20473.1 - 3e-07 30.3 0.0 0.00051 19.7 0.0 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 AMD20473.1 - 2.3e-05 23.7 0.0 3.8e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 AMD20473.1 - 5.8e-05 23.3 0.0 0.00013 22.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 AMD20473.1 - 0.00015 22.3 0.0 0.00061 20.3 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 AMD20473.1 - 0.00028 20.0 0.3 0.0012 17.9 0.1 1.9 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.14 AMD20473.1 - 0.00075 18.8 0.0 0.001 18.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AMD20473.1 - 0.00096 18.3 0.0 0.0056 15.8 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 AMD20473.1 - 0.0042 17.0 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 AMD20473.1 - 0.0057 16.3 0.0 0.0092 15.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 AMD20473.1 - 0.013 14.9 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AMD20473.1 - 0.015 14.0 0.0 0.023 13.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 AMD20473.1 - 0.056 12.3 0.0 2.9 6.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.23 AMD20473.1 - 0.062 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF1495 PF07381.11 AMD20473.1 - 0.1 12.5 0.0 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Winged helix DNA-binding domain (DUF1495) NAD_binding_2 PF03446.15 AMD20473.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase FAD_oxidored PF12831.7 AMD20473.1 - 0.19 11.0 0.0 0.45 9.8 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Cnd2 PF05786.14 AMD20474.1 - 3.1e-131 439.5 33.9 4.9e-129 432.3 33.9 2.7 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 AMD20474.1 - 0.00027 21.1 0.0 0.0012 19.1 0.0 2.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Nuc_rec_co-act PF08815.10 AMD20474.1 - 0.0037 17.1 0.2 0.12 12.2 0.2 2.6 2 0 0 2 2 2 1 Nuclear receptor coactivator Peptidase_M41 PF01434.18 AMD20475.1 - 1.1e-59 201.5 0.1 2.1e-59 200.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AMD20475.1 - 3.7e-41 140.6 0.0 7.5e-41 139.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD20475.1 - 9e-08 31.8 0.0 2.7e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AMD20475.1 - 7.9e-06 26.4 1.0 0.0001 22.7 0.4 2.7 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 AMD20475.1 - 0.00016 22.0 0.4 0.14 12.4 0.1 3.1 2 1 0 3 3 3 1 AAA domain TIP49 PF06068.13 AMD20475.1 - 0.00058 19.2 0.0 0.0012 18.2 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 AMD20475.1 - 0.0014 18.7 0.1 0.0063 16.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AMD20475.1 - 0.0016 18.2 0.0 0.0063 16.3 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 AMD20475.1 - 0.0077 16.4 0.0 0.17 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AMD20475.1 - 0.02 14.6 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 AMD20475.1 - 0.028 14.6 0.0 0.12 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) CHAT PF12770.7 AMD20475.1 - 0.05 13.0 0.0 0.18 11.2 0.0 1.9 3 0 0 3 3 3 0 CHAT domain Mg_chelatase PF01078.21 AMD20475.1 - 0.052 12.9 0.1 0.11 11.8 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AMD20475.1 - 0.06 13.9 0.1 0.35 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AMD20475.1 - 0.076 12.6 0.8 1.1 8.8 0.3 2.4 1 1 0 2 2 2 0 AAA domain TsaE PF02367.17 AMD20475.1 - 0.094 12.7 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cyclin_C_2 PF16899.5 AMD20476.1 - 2.1e-30 105.2 0.5 7.5e-28 97.0 0.0 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 AMD20476.1 - 2.3e-09 37.1 0.6 4.5e-09 36.1 0.6 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.19 AMD20476.1 - 0.00016 21.6 0.0 0.00029 20.8 0.0 1.5 1 0 0 1 1 1 1 Transcription factor TFIIB repeat ATP-synt_ab PF00006.25 AMD20477.1 - 9e-73 244.4 0.1 1.6e-72 243.6 0.0 1.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 AMD20477.1 - 1.6e-46 157.7 1.9 2.7e-46 157.0 1.9 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 AMD20477.1 - 4.6e-16 59.1 2.5 1.5e-15 57.5 2.5 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4392 PF14336.6 AMD20477.1 - 0.017 14.6 0.0 5.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4392) HTH_IclR PF09339.10 AMD20477.1 - 0.07 12.9 0.0 0.25 11.2 0.0 1.9 1 0 0 1 1 1 0 IclR helix-turn-helix domain Glyco_hydro_65m PF03632.15 AMD20478.1 - 7.5e-32 110.6 4.0 2.3e-29 102.5 1.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.15 AMD20478.1 - 4.2e-18 65.8 0.0 8.4e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.15 AMD20478.1 - 0.00021 21.1 0.0 0.00048 20.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain TB2_DP1_HVA22 PF03134.19 AMD20479.1 - 8e-28 96.2 7.8 1.2e-27 95.6 7.8 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Adaptin_N PF01602.20 AMD20480.1 - 4.2e-105 352.3 14.2 5.4e-105 351.9 14.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 AMD20480.1 - 4.4e-08 33.4 0.1 1.1e-07 32.1 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT PF02985.22 AMD20480.1 - 0.07 13.4 0.5 28 5.3 0.1 3.8 3 0 0 3 3 3 0 HEAT repeat Arrestin_C PF02752.22 AMD20481.1 - 7.6e-10 39.4 0.6 1.6e-08 35.1 0.6 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Got1 PF04178.12 AMD20482.1 - 2.3e-32 111.7 16.9 3.3e-32 111.2 16.9 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2207 PF09972.9 AMD20482.1 - 0.81 8.4 7.1 6.8 5.3 7.1 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) HLH PF00010.26 AMD20483.1 - 2e-12 46.9 0.9 4.4e-12 45.8 0.9 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Cyclin_N PF00134.23 AMD20484.1 - 1.5e-41 141.1 0.0 2.7e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AMD20484.1 - 2.2e-34 118.1 0.2 6e-34 116.7 0.1 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain Sas10 PF09368.10 AMD20485.1 - 4.2e-29 100.8 12.4 4.2e-29 100.8 12.4 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 AMD20485.1 - 3.5e-06 27.5 2.8 1.2e-05 25.8 0.0 3.2 1 1 1 2 2 2 1 Sas10/Utp3/C1D family RNA_pol_Rpc4 PF05132.14 AMD20486.1 - 2.4e-28 99.5 0.6 2.4e-28 99.5 0.6 3.4 3 1 0 3 3 3 1 RNA polymerase III RPC4 TraC PF07820.12 AMD20486.1 - 0.021 15.1 0.2 0.049 14.0 0.2 1.6 1 0 0 1 1 1 0 TraC-like protein APG9 PF04109.16 AMD20487.1 - 2.4e-190 633.6 16.6 2.9e-190 633.4 16.6 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Nop14 PF04147.12 AMD20488.1 - 3.8e-184 614.4 53.5 3.7e-105 353.1 15.5 2.2 1 1 1 2 2 2 2 Nop14-like family PCI PF01399.27 AMD20489.1 - 4.4e-22 78.6 3.5 2.2e-21 76.4 0.0 2.8 2 1 0 2 2 2 1 PCI domain RPN5_C PF18098.1 AMD20489.1 - 7.6e-15 54.7 5.7 1.5e-14 53.8 4.4 2.2 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN5 C-terminal domain TPR_MalT PF17874.1 AMD20489.1 - 0.0033 16.8 1.1 0.018 14.5 0.0 2.5 3 0 0 3 3 3 1 MalT-like TPR region DUF4864 PF16156.5 AMD20489.1 - 0.019 15.6 0.3 0.8 10.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4864) TPR_20 PF14561.6 AMD20489.1 - 0.025 14.9 1.6 0.15 12.4 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat NPV_P10 PF05531.12 AMD20489.1 - 1.2 9.6 6.8 0.23 12.0 0.3 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CCDC85 PF10226.9 AMD20490.1 - 0.0088 15.7 2.3 0.0088 15.7 2.3 2.0 2 0 0 2 2 2 1 CCDC85 family DUF2536 PF10750.9 AMD20490.1 - 0.34 10.8 5.1 0.15 11.9 0.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2536) PilJ PF13675.6 AMD20490.1 - 0.47 10.5 4.5 0.16 12.0 1.4 1.9 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term MetOD2 PF18548.1 AMD20490.1 - 0.63 10.2 8.2 0.85 9.8 1.1 2.7 2 1 1 3 3 3 0 Metanogen output domain 2 GIT_CC PF16559.5 AMD20490.1 - 2.3 8.2 10.2 0.18 11.7 1.7 3.0 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 AMD20490.1 - 2.8 8.6 11.7 0.6 10.8 5.0 2.5 2 1 1 3 3 3 0 Initiation control protein YabA Uso1_p115_C PF04871.13 AMD20490.1 - 3.4 8.0 11.7 2.5 8.5 5.6 2.5 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2013 PF09431.10 AMD20491.1 - 4.2e-38 130.6 11.6 4.2e-38 130.6 11.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Ovate PF04844.13 AMD20491.1 - 0.2 11.7 2.3 0.46 10.5 0.1 2.7 2 0 0 2 2 2 0 Transcriptional repressor, ovate Tubulin PF00091.25 AMD20492.1 - 7.4e-68 228.6 0.0 1.1e-67 228.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AMD20492.1 - 4.4e-31 107.7 0.0 1.3e-30 106.2 0.0 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 AMD20492.1 - 1.7e-06 28.4 0.0 5.5e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 AMD20492.1 - 0.023 13.9 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Coatomer_WDAD PF04053.14 AMD20493.1 - 5.1e-132 441.1 4.6 7.5e-132 440.5 4.6 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 AMD20493.1 - 1.3e-81 274.4 0.0 1.9e-81 273.9 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 AMD20493.1 - 5.1e-37 125.2 21.5 1.9e-07 31.7 0.1 8.1 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20493.1 - 1.4e-11 44.5 0.2 3.8e-05 23.9 0.0 5.6 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD20493.1 - 8.1e-05 22.6 0.9 0.74 9.7 0.0 3.7 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 AMD20493.1 - 0.03 13.0 7.8 2.5 6.6 0.0 4.3 3 1 2 5 5 5 0 Nucleoporin Nup120/160 Herpes_MCP PF03122.14 AMD20493.1 - 0.046 11.2 0.0 0.22 9.0 0.0 1.8 2 0 0 2 2 2 0 Herpes virus major capsid protein ENTH PF01417.20 AMD20493.1 - 0.096 12.7 1.0 1.1 9.3 0.1 2.7 2 0 0 2 2 2 0 ENTH domain SH3_10 PF17902.1 AMD20493.1 - 0.18 11.9 0.1 0.46 10.6 0.1 1.6 1 0 0 1 1 1 0 SH3 domain TPR_2 PF07719.17 AMD20493.1 - 6.5 7.1 6.8 3.5 8.0 0.0 3.8 4 1 1 5 5 5 0 Tetratricopeptide repeat Glyco_hydro_16 PF00722.21 AMD20494.1 - 4.3e-47 159.9 0.2 6.1e-47 159.4 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 WAP PF00095.21 AMD20494.1 - 0.027 14.8 4.1 0.048 14.1 4.1 1.3 1 0 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' DUF2243 PF10002.9 AMD20494.1 - 0.16 12.1 0.4 0.32 11.1 0.4 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2243) Chitin_bind_1 PF00187.19 AMD20494.1 - 3.7 8.1 11.1 6.6 7.3 11.1 1.3 1 0 0 1 1 1 0 Chitin recognition protein ApbA_C PF08546.11 AMD20495.1 - 6.2e-27 94.3 0.0 1e-26 93.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 AMD20495.1 - 9.7e-21 74.0 0.0 1.9e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DAO PF01266.24 AMD20495.1 - 0.0077 15.8 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 AMD20495.1 - 0.014 16.0 0.1 0.061 13.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AMD20495.1 - 0.026 14.7 0.2 0.054 13.7 0.2 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF2092 PF09865.9 AMD20495.1 - 0.032 13.6 0.0 0.087 12.2 0.0 1.7 2 0 0 2 2 2 0 Predicted periplasmic protein (DUF2092) NAD_binding_7 PF13241.6 AMD20495.1 - 0.074 13.5 0.0 0.23 11.9 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding LisH_2 PF16045.5 AMD20495.1 - 0.075 12.1 0.1 0.15 11.1 0.1 1.5 1 0 0 1 1 1 0 LisH Glu_dehyd_C PF16912.5 AMD20495.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.5 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Ferric_reduct PF01794.19 AMD20496.1 - 4.5e-25 88.2 9.1 1.4e-24 86.6 9.1 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AMD20496.1 - 2.3e-21 75.9 0.1 5.2e-21 74.8 0.1 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 AMD20496.1 - 2.9e-09 37.3 0.0 5.1e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF4405 PF14358.6 AMD20496.1 - 0.0019 18.7 5.9 0.26 11.8 1.1 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4405) D123 PF07065.14 AMD20497.1 - 3.6e-110 367.9 2.6 4.4e-110 367.6 2.6 1.1 1 0 0 1 1 1 1 D123 R2K_3 PF14243.6 AMD20497.1 - 0.04 13.9 0.0 0.068 13.2 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 AMD20497.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Cpn60_TCP1 PF00118.24 AMD20498.1 - 2.6e-145 484.8 12.3 3e-145 484.6 12.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CDP-OH_P_transf PF01066.21 AMD20499.1 - 1.6e-15 57.6 1.1 1.6e-15 57.6 1.1 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Mito_carr PF00153.27 AMD20500.1 - 6.1e-48 160.7 5.0 3e-17 62.3 0.1 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Prenyltrans PF00432.21 AMD20501.1 - 4e-33 112.8 6.2 2e-07 30.6 0.0 5.0 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat DUF5616 PF18481.1 AMD20501.1 - 0.0071 16.7 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5616) Glyco_hydro_38N PF01074.22 AMD20502.1 - 5.5e-80 268.8 0.4 9.4e-80 268.1 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 AMD20502.1 - 3e-51 174.5 0.6 5.2e-51 173.7 0.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 AMD20502.1 - 2.7e-26 91.5 0.0 9.2e-26 89.8 0.0 1.9 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 AMD20502.1 - 1.4e-06 28.3 0.1 8.2e-06 25.8 0.0 2.4 2 1 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain HMG_CoA_synt_C PF08540.10 AMD20502.1 - 0.018 14.6 1.0 0.75 9.4 0.1 2.5 2 0 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal Inhibitor_I9 PF05922.16 AMD20503.1 - 0.014 16.0 0.1 0.24 12.1 0.1 2.3 1 1 0 1 1 1 0 Peptidase inhibitor I9 Frataxin_Cyay PF01491.16 AMD20504.1 - 1.1e-36 125.2 0.1 1.5e-36 124.8 0.1 1.1 1 0 0 1 1 1 1 Frataxin-like domain CPSase_sm_chain PF00988.22 AMD20504.1 - 0.023 14.5 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain UCH PF00443.29 AMD20504.1 - 0.066 12.7 0.2 0.098 12.1 0.2 1.3 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase SAC3_GANP PF03399.16 AMD20504.1 - 0.085 12.2 0.1 0.12 11.7 0.1 1.1 1 0 0 1 1 1 0 SAC3/GANP family TTRAP PF14203.6 AMD20504.1 - 0.1 12.6 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein HCMV_UL139 PF12507.8 AMD20505.1 - 0.13 12.7 1.5 0.17 12.3 1.5 1.1 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein UCH PF00443.29 AMD20506.1 - 2e-43 148.8 0.0 4.4e-43 147.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD20506.1 - 9e-06 25.5 5.3 0.27 10.8 5.1 3.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RRM_1 PF00076.22 AMD20507.1 - 2.7e-52 174.5 1.9 1.2e-18 66.7 0.4 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AMD20507.1 - 2.2e-07 30.6 0.0 0.0017 18.2 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 AMD20507.1 - 0.0001 22.3 0.6 0.18 11.9 0.1 3.8 3 1 1 4 4 4 1 RNA recognition motif RRM_5 PF13893.6 AMD20507.1 - 0.00047 19.8 0.1 0.03 13.9 0.1 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 AMD20507.1 - 0.0037 17.5 0.1 6.2 7.0 0.0 3.0 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter DUF4152 PF13680.6 AMD20507.1 - 0.066 12.6 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4152) Nup35_RRM_2 PF14605.6 AMD20507.1 - 0.068 13.2 0.2 1.3 9.1 0.1 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 AMD20507.1 - 0.13 12.3 0.3 21 5.2 0.1 2.5 2 0 0 2 2 2 0 RNA binding motif RRM_8 PF11835.8 AMD20507.1 - 0.17 12.1 0.0 0.51 10.6 0.0 1.7 2 0 0 2 2 2 0 RRM-like domain DFP PF04127.15 AMD20508.1 - 1.9e-17 63.7 0.0 1.8e-09 37.7 0.0 2.5 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Bac_surface_Ag PF01103.23 AMD20509.1 - 2.5e-46 158.7 6.4 3.4e-46 158.3 6.4 1.2 1 0 0 1 1 1 1 Surface antigen zf-C2H2 PF00096.26 AMD20510.1 - 5.1e-14 51.8 12.7 9.3e-07 29.0 2.3 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD20510.1 - 2.2e-12 46.8 10.2 6.6e-07 29.5 0.4 4.0 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD20510.1 - 2.5e-08 34.1 11.4 0.0012 19.5 1.3 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 AMD20510.1 - 8.3e-07 29.2 3.9 5.9e-05 23.3 0.4 3.0 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD20510.1 - 4.6e-06 26.8 6.2 0.0034 17.6 0.5 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AMD20510.1 - 8.4e-06 25.7 7.4 0.0038 17.2 0.2 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger Zn_ribbon_recom PF13408.6 AMD20510.1 - 0.0022 18.4 2.1 0.0022 18.4 2.1 2.0 2 0 0 2 2 1 1 Recombinase zinc beta ribbon domain FYVE PF01363.21 AMD20510.1 - 0.12 12.5 4.2 0.24 11.6 4.2 1.5 1 0 0 1 1 1 0 FYVE zinc finger Zn-ribbon_8 PF09723.10 AMD20510.1 - 0.33 11.1 1.0 0.88 9.7 1.0 1.8 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 AMD20510.1 - 0.36 10.6 3.2 36 4.2 0.2 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-BED PF02892.15 AMD20510.1 - 0.56 10.3 3.6 15 5.7 1.7 3.0 2 1 0 2 2 2 0 BED zinc finger zf-H2C2_5 PF13909.6 AMD20510.1 - 0.77 9.6 4.1 2.3 8.1 3.6 2.1 2 0 0 2 2 2 0 C2H2-type zinc-finger domain C1_2 PF03107.16 AMD20510.1 - 0.93 9.9 3.7 7.2 7.0 0.3 2.6 1 1 1 2 2 2 0 C1 domain zf-C2HE PF16278.5 AMD20510.1 - 1.5 9.3 4.1 1.3e+02 3.1 4.0 3.2 2 1 0 2 2 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.16 AMD20510.1 - 1.8 8.8 5.3 4.7 7.5 1.3 2.4 2 0 0 2 2 2 0 AN1-like Zinc finger SR-25 PF10500.9 AMD20510.1 - 3.5 7.2 11.3 6.7 6.2 11.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sds3 PF08598.11 AMD20511.1 - 1.5e-70 237.6 6.3 1.9e-70 237.3 6.3 1.1 1 0 0 1 1 1 1 Sds3-like EF-1_beta_acid PF10587.9 AMD20511.1 - 0.34 11.4 0.1 0.34 11.4 0.1 3.3 4 0 0 4 4 4 0 Eukaryotic elongation factor 1 beta central acidic region CENP-T_C PF15511.6 AMD20512.1 - 2.6e-09 37.2 0.1 3.2e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 AMD20512.1 - 2.8e-05 24.5 0.1 3.2e-05 24.3 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AMD20512.1 - 4.6e-05 23.5 0.2 6.8e-05 23.0 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 AMD20512.1 - 8.8e-05 22.7 0.1 0.00016 21.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 AMD20512.1 - 0.0002 21.6 0.1 0.00027 21.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 AMD20512.1 - 0.0039 17.3 0.0 0.0046 17.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 AMD20512.1 - 0.0073 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 AMD20512.1 - 0.044 14.3 0.1 0.075 13.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 AMD20513.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 AMD20513.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 AMD20513.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 AMD20513.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 AMD20513.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 AMD20513.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Aim19 PF10315.9 AMD20514.1 - 4.3e-38 130.2 2.7 5e-38 130.0 2.7 1.0 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Y_phosphatase2 PF03162.13 AMD20515.1 - 2.6e-63 212.5 0.1 3.3e-63 212.1 0.1 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AMD20515.1 - 4.5e-06 26.8 0.0 5.6e-06 26.5 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AMD20515.1 - 0.0013 18.5 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AMD20515.1 - 0.0058 16.2 0.0 0.0081 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Aa_trans PF01490.18 AMD20516.1 - 4.1e-100 335.4 12.7 4.9e-100 335.1 12.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TRAM_LAG1_CLN8 PF03798.16 AMD20517.1 - 1.3e-40 139.3 24.1 1.3e-40 139.3 24.1 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 AMD20517.1 - 2.2e-14 52.8 0.8 2.2e-14 52.8 0.8 2.5 2 0 0 2 2 2 1 TRAM1-like protein Cyclin_N PF00134.23 AMD20518.1 - 2.6e-17 62.7 0.5 3.1e-16 59.3 0.2 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 AMD20518.1 - 1e-05 25.8 0.1 3.1e-05 24.3 0.1 1.9 1 1 0 1 1 1 1 Cyclin C-terminal domain Cyclin_C PF02984.19 AMD20518.1 - 0.00016 21.8 0.4 0.066 13.3 0.0 2.2 2 0 0 2 2 2 2 Cyclin, C-terminal domain ICE2 PF08426.10 AMD20519.1 - 1.1e-144 482.6 31.1 1.3e-144 482.3 31.1 1.0 1 0 0 1 1 1 1 ICE2 UTP25 PF06862.12 AMD20520.1 - 2.1e-195 650.0 15.0 3.1e-195 649.5 15.0 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 AMD20520.1 - 1.3e-06 28.3 0.1 0.015 15.1 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase DUF2151 PF10221.9 AMD20520.1 - 0.41 9.2 10.4 2.3 6.7 11.3 1.8 2 0 0 2 2 2 0 Cell cycle and development regulator DUF5523 PF17661.1 AMD20520.1 - 1.6 8.4 21.2 3.7 7.2 21.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF1242 PF06842.12 AMD20521.1 - 2.3e-13 49.7 0.1 3.2e-13 49.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) MRP-S25 PF13741.6 AMD20522.1 - 4.2e-88 294.8 1.0 4.9e-88 294.6 1.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 AMD20522.1 - 1.4e-05 25.3 1.4 0.055 13.7 0.1 2.5 1 1 0 2 2 2 2 Mitochondrial ribosomal protein S23 R3H PF01424.22 AMD20523.1 - 1.8e-18 66.3 0.3 3.5e-18 65.3 0.3 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 AMD20523.1 - 1.9e-06 27.8 33.8 6.3e-05 22.9 14.2 11.7 11 1 0 11 11 11 4 NF-X1 type zinc finger Iso_dh PF00180.20 AMD20524.1 - 1.8e-103 346.3 0.1 2.1e-103 346.1 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.12 AMD20524.1 - 0.092 12.1 0.1 0.23 10.9 0.0 1.6 2 0 0 2 2 2 0 Pyridoxal phosphate biosynthetic protein PdxA Methyltr_RsmB-F PF01189.17 AMD20525.1 - 1.5e-18 67.1 0.0 5.9e-11 42.4 0.0 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Arb2 PF09757.9 AMD20526.1 - 4.7e-92 307.8 0.0 6.3e-92 307.4 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 AMD20526.1 - 2.7e-89 299.7 0.0 5e-89 298.8 0.0 1.4 2 0 0 2 2 2 1 Histone deacetylase domain Pkinase PF00069.25 AMD20527.1 - 5.1e-39 134.2 0.0 7.2e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20527.1 - 5.7e-26 91.4 0.0 7.7e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20527.1 - 0.0002 20.8 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD20527.1 - 0.012 15.6 0.0 1.7 8.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AMD20527.1 - 0.026 13.5 0.0 0.054 12.4 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Dabb PF07876.12 AMD20527.1 - 0.083 13.5 0.0 0.25 12.0 0.0 1.7 2 0 0 2 2 2 0 Stress responsive A/B Barrel Domain WD40 PF00400.32 AMD20528.1 - 1.8e-08 34.9 3.6 0.0005 20.8 0.3 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20528.1 - 2.1e-05 24.7 0.0 1.1 9.6 0.0 3.7 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 AMD20528.1 - 0.023 13.5 0.0 0.095 11.4 0.0 1.9 1 1 1 2 2 2 0 Nup133 N terminal like Ge1_WD40 PF16529.5 AMD20528.1 - 0.067 12.1 0.0 0.26 10.2 0.0 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_NNT PF03264.14 AMD20528.1 - 0.078 12.7 1.1 0.13 12.0 1.1 1.2 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region Myb_DNA-bind_7 PF15963.5 AMD20529.1 - 9.1e-27 92.8 0.2 9.1e-27 92.8 0.2 2.9 3 1 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 AMD20529.1 - 4.9e-09 36.2 0.0 1.1e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD20529.1 - 0.037 14.3 0.1 0.037 14.3 0.1 2.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain Mt_ATP-synt_D PF05873.12 AMD20529.1 - 0.28 11.0 7.4 0.049 13.5 0.8 2.5 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) PulA_N1 PF17999.1 AMD20529.1 - 0.54 11.0 3.2 12 6.7 0.1 3.1 2 1 0 2 2 2 0 Pullulanase N1-terminal domain CotJB PF12652.7 AMD20529.1 - 1.4 9.2 5.8 0.41 10.9 0.3 2.5 2 0 0 2 2 2 0 CotJB protein PIG-H PF10181.9 AMD20530.1 - 6.1e-22 77.3 0.8 9.9e-22 76.6 0.8 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DUF2431 PF10354.9 AMD20531.1 - 2.4e-48 164.6 0.5 4.2e-48 163.8 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) Prenylcys_lyase PF07156.14 AMD20531.1 - 0.039 13.1 0.0 0.06 12.5 0.0 1.2 1 0 0 1 1 1 0 Prenylcysteine lyase CLTH PF10607.9 AMD20532.1 - 1.4e-29 102.9 0.6 1.4e-29 102.9 0.6 2.1 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Herpes_U30 PF04523.13 AMD20532.1 - 0.027 12.4 0.3 0.04 11.8 0.3 1.1 1 0 0 1 1 1 0 Herpes virus tegument protein U30 U-box PF04564.15 AMD20532.1 - 0.034 14.3 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 U-box domain Pilin_PilX PF11530.8 AMD20532.1 - 0.076 12.9 0.2 0.22 11.4 0.1 1.8 2 0 0 2 2 2 0 Minor type IV pilin, PilX Iso_dh PF00180.20 AMD20533.1 - 2.9e-82 276.6 0.0 3.6e-82 276.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pim PF16765.5 AMD20533.1 - 0.02 15.0 0.1 2.3 8.4 0.0 2.4 2 0 0 2 2 2 0 Pesticin immunity protein Complex1_LYR_2 PF13233.6 AMD20534.1 - 6.2e-17 62.1 8.8 6e-16 59.0 8.8 2.1 1 1 0 1 1 1 1 Complex1_LYR-like Speriolin_N PF15058.6 AMD20534.1 - 0.19 11.8 1.5 1.1 9.4 1.5 1.9 1 1 0 1 1 1 0 Speriolin N terminus MRP-L28 PF09812.9 AMD20534.1 - 0.51 10.5 8.1 0.25 11.5 0.3 2.1 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L28 DUF4337 PF14235.6 AMD20534.1 - 6.8 6.8 7.5 5.2 7.2 1.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Glyco_hydro_15 PF00723.21 AMD20535.1 - 6.5e-52 176.8 0.0 1.1e-51 176.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Pro_CA PF00484.19 AMD20536.1 - 4.6e-41 140.7 0.0 5.6e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Helicase_IV_N PF12462.8 AMD20536.1 - 0.072 13.0 0.3 0.11 12.5 0.3 1.2 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Pkinase PF00069.25 AMD20538.1 - 1.1e-55 188.8 0.2 1.7e-55 188.3 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20538.1 - 4.3e-35 121.2 0.0 6.4e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AMD20538.1 - 7.4e-17 61.5 0.0 2.1e-16 60.0 0.0 1.8 1 0 0 1 1 1 1 FHA domain Pkinase_fungal PF17667.1 AMD20538.1 - 2.1e-09 36.7 0.0 8.4e-09 34.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 AMD20538.1 - 0.0003 20.2 0.0 0.00047 19.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AMD20538.1 - 0.00048 19.5 0.0 0.00077 18.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Yop-YscD_cpl PF16697.5 AMD20538.1 - 0.0053 17.1 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Haspin_kinase PF12330.8 AMD20538.1 - 0.034 13.1 1.3 0.039 12.9 0.1 1.7 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 AMD20538.1 - 0.04 13.8 0.0 0.13 12.1 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family TFB6 PF17110.5 AMD20539.1 - 9.1e-31 106.9 0.0 1.8e-27 96.2 0.0 2.4 1 1 1 2 2 2 2 Subunit 11 of the general transcription factor TFIIH SOG2 PF10428.9 AMD20540.1 - 9e-112 374.9 24.3 9e-112 374.9 24.3 2.9 2 1 0 2 2 2 1 RAM signalling pathway protein LRR_8 PF13855.6 AMD20540.1 - 3.4e-13 49.2 9.7 5e-08 32.6 1.5 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 AMD20540.1 - 2.8e-12 46.6 12.7 2.6e-07 30.8 1.1 4.0 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 AMD20540.1 - 0.0021 18.3 4.1 8.6 7.3 0.1 5.0 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_9 PF14580.6 AMD20540.1 - 0.022 14.3 3.5 0.034 13.7 0.6 2.6 2 1 0 2 2 2 0 Leucine-rich repeat LRR_5 PF13306.6 AMD20540.1 - 0.025 14.5 0.2 0.14 12.1 0.1 2.2 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 AMD20540.1 - 1 9.6 11.7 1.7 8.9 0.0 4.4 5 0 0 5 5 5 0 Leucine Rich repeat Cyto_heme_lyase PF01265.17 AMD20541.1 - 1.1e-95 320.6 5.9 4.2e-95 318.7 5.9 1.7 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase Cyclin_N PF00134.23 AMD20543.1 - 1.2e-31 109.1 0.6 2.2e-31 108.3 0.6 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cupin_8 PF13621.6 AMD20544.1 - 1.1e-38 133.5 0.0 5.8e-37 127.8 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 AMD20544.1 - 0.02 15.3 0.1 0.048 14.1 0.1 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_4 PF08007.12 AMD20544.1 - 0.045 13.2 0.3 8.5 5.7 0.0 2.9 3 1 0 3 3 3 0 Cupin superfamily protein ETF_QO PF05187.13 AMD20546.1 - 2e-44 150.0 0.4 3.2e-44 149.3 0.4 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 AMD20546.1 - 6e-11 42.5 0.6 6.6e-06 25.9 0.4 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AMD20546.1 - 5.8e-08 32.2 1.2 0.0016 17.6 0.8 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 AMD20546.1 - 1.5e-06 28.3 0.1 4e-06 26.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AMD20546.1 - 1.5e-06 27.7 0.1 0.00023 20.5 0.1 2.2 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AMD20546.1 - 3.5e-05 23.2 0.0 7e-05 22.2 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 AMD20546.1 - 9.5e-05 21.3 0.5 0.0014 17.4 0.3 2.0 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 AMD20546.1 - 0.00014 21.2 0.0 0.017 14.4 0.1 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 AMD20546.1 - 0.00024 21.6 0.5 0.071 13.7 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AMD20546.1 - 0.00037 19.9 0.4 0.00069 19.0 0.4 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AMD20546.1 - 0.0041 17.1 0.4 0.0092 16.0 0.4 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 AMD20546.1 - 0.019 14.0 0.2 0.029 13.4 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 AMD20546.1 - 0.021 13.7 0.6 0.61 8.9 0.3 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Fer4_7 PF12838.7 AMD20546.1 - 0.036 14.7 0.7 0.11 13.2 0.7 1.8 1 0 0 1 1 1 0 4Fe-4S dicluster domain FAD_oxidored PF12831.7 AMD20546.1 - 0.038 13.3 0.9 0.066 12.6 0.9 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 AMD20546.1 - 0.11 11.7 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fer4_2 PF12797.7 AMD20546.1 - 5.9 7.2 6.5 0.3 11.3 0.5 2.1 2 0 0 2 2 1 0 4Fe-4S binding domain CDC24 PF06395.11 AMD20547.1 - 2.3e-35 120.7 1.4 4.7e-35 119.7 0.6 2.1 2 0 0 2 2 2 1 CDC24 Calponin RhoGEF PF00621.20 AMD20547.1 - 2e-33 116.2 4.5 7.5e-33 114.3 4.5 2.0 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 AMD20547.1 - 2.4e-31 108.6 0.1 6.1e-31 107.2 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 AMD20547.1 - 1.2e-06 28.4 0.4 4e-06 26.7 0.4 2.0 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 AMD20547.1 - 0.047 14.2 1.8 0.52 10.8 1.8 2.8 1 1 0 1 1 1 0 PH domain COPIIcoated_ERV PF07970.12 AMD20548.1 - 3.8e-74 249.3 0.0 5e-74 248.9 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 AMD20548.1 - 9.3e-26 90.0 0.0 2.9e-25 88.4 0.1 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PX PF00787.24 AMD20549.1 - 1.5e-21 76.5 0.0 1.9e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 PX domain Histone PF00125.24 AMD20550.1 - 3.5e-26 92.1 0.3 3.8e-26 92.0 0.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AMD20550.1 - 2.5e-22 78.9 1.6 2.5e-22 78.9 1.6 1.4 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAFII28 PF04719.14 AMD20550.1 - 0.0038 17.3 0.3 0.0054 16.8 0.3 1.2 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CENP-X PF09415.10 AMD20550.1 - 0.0092 16.3 0.1 0.017 15.4 0.1 1.5 1 0 0 1 1 1 1 CENP-S associating Centromere protein X DUF3791 PF12668.7 AMD20550.1 - 0.014 15.5 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) Peptidase_Mx PF15887.5 AMD20550.1 - 0.02 14.3 0.1 0.045 13.1 0.0 1.6 2 0 0 2 2 2 0 Putative zinc-binding metallo-peptidase ISP3_C PF18045.1 AMD20550.1 - 0.041 13.7 0.2 1.7 8.6 0.0 2.1 1 1 1 2 2 2 0 ISP3 C-terminal CENP-W PF15510.6 AMD20550.1 - 0.081 13.1 0.1 0.11 12.7 0.1 1.1 1 0 0 1 1 1 0 CENP-W protein TAF PF02969.17 AMD20550.1 - 0.097 12.9 0.2 0.17 12.1 0.2 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) DUF3453 PF11935.8 AMD20551.1 - 1.5e-48 165.5 0.1 2.3e-48 164.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) K_channel_TID PF07941.11 AMD20551.1 - 0.003 18.0 0.6 0.003 18.0 0.6 3.1 2 1 0 2 2 2 1 Potassium channel Kv1.4 tandem inactivation domain DUF5315 PF17242.2 AMD20551.1 - 0.04 13.7 0.4 0.49 10.2 0.1 2.5 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) SAM_1 PF00536.30 AMD20552.1 - 8.1e-06 26.2 0.5 2.4e-05 24.7 0.0 2.0 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 AMD20552.1 - 8.1e-05 22.7 0.0 0.00017 21.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Rod-binding PF10135.9 AMD20552.1 - 0.084 13.5 0.6 0.32 11.6 0.6 2.1 1 0 0 1 1 1 0 Rod binding protein BAG PF02179.16 AMD20552.1 - 0.22 12.0 0.0 8.6 6.9 0.0 2.3 2 0 0 2 2 2 0 BAG domain PDEase_I PF00233.19 AMD20553.1 - 3.5e-48 164.4 0.1 7.4e-48 163.3 0.0 1.6 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GCV_H PF01597.19 AMD20554.1 - 3.8e-43 146.3 0.1 4.6e-43 146.0 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein BolA PF01722.18 AMD20555.1 - 6.9e-26 90.3 1.7 8.4e-26 90.1 1.7 1.1 1 0 0 1 1 1 1 BolA-like protein BolA PF01722.18 AMD20556.1 - 2.5e-13 50.1 0.0 7.1e-13 48.6 0.0 1.7 1 1 0 1 1 1 1 BolA-like protein Cmyb_C PF09316.10 AMD20556.1 - 0.051 13.2 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 C-myb, C-terminal NUC153 PF08159.12 AMD20556.1 - 0.069 13.0 0.6 0.096 12.5 0.0 1.6 2 0 0 2 2 2 0 NUC153 domain eIF2A PF08662.11 AMD20557.1 - 1.5e-25 90.2 1.3 2.3e-21 76.6 1.5 4.2 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 AMD20557.1 - 6e-10 38.8 0.3 1.6e-09 37.4 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-F_leu_zip PF10473.9 AMD20558.1 - 0.0046 17.0 3.2 0.0046 17.0 3.2 6.9 3 2 5 8 8 8 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF641 PF04859.12 AMD20558.1 - 0.48 10.8 40.3 0.12 12.7 1.7 6.4 3 2 3 6 6 6 0 Plant protein of unknown function (DUF641) DUF948 PF06103.11 AMD20558.1 - 1.2 9.5 20.1 0.68 10.2 0.8 4.7 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Filament PF00038.21 AMD20558.1 - 2.2 7.8 65.9 0.37 10.3 0.2 5.3 3 2 2 5 5 5 0 Intermediate filament protein Proteasome PF00227.26 AMD20559.1 - 1.1e-51 175.0 0.1 3.8e-51 173.3 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 AMD20559.1 - 5.8e-12 45.1 0.0 5.8e-12 45.1 0.0 1.9 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature EF_assoc_1 PF08355.12 AMD20560.1 - 1.7e-27 94.8 0.7 3.2e-27 93.9 0.7 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 AMD20560.1 - 4.9e-26 91.3 0.0 3.1e-13 49.6 0.0 2.5 2 0 0 2 2 2 2 Ras family EF_assoc_2 PF08356.12 AMD20560.1 - 1.3e-24 86.0 0.0 4.4e-24 84.3 0.0 1.9 2 0 0 2 2 1 1 EF hand associated Roc PF08477.13 AMD20560.1 - 9.4e-16 58.1 0.0 5.1e-07 29.9 0.0 3.3 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_1 PF00036.32 AMD20560.1 - 1.7e-11 42.8 4.5 0.00014 21.2 0.3 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 AMD20560.1 - 6.8e-10 38.1 4.2 0.00024 20.8 0.1 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 AMD20560.1 - 1.3e-07 32.0 0.8 0.032 14.7 0.2 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 AMD20560.1 - 1.5e-06 27.4 1.4 0.0011 18.4 0.3 2.7 2 0 0 2 2 2 2 EF hand Dynamin_N PF00350.23 AMD20560.1 - 3.3e-06 27.3 0.1 0.021 14.9 0.0 2.5 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 AMD20560.1 - 2.1e-05 24.5 0.0 0.029 14.4 0.0 2.9 2 1 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AMD20560.1 - 0.00014 21.5 0.0 1.3 8.5 0.0 3.3 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AMD20560.1 - 0.00017 21.5 0.5 0.044 13.7 0.0 3.5 3 1 1 4 4 4 1 RsgA GTPase AAA_16 PF13191.6 AMD20560.1 - 0.0011 19.4 0.0 2.1 8.7 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain ABC_tran PF00005.27 AMD20560.1 - 0.0014 19.2 0.0 0.076 13.5 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 AMD20560.1 - 0.0022 17.7 0.0 0.73 9.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 AMD20560.1 - 0.0036 17.6 0.0 1.9 8.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 AMD20560.1 - 0.02 14.7 0.1 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Septin PF00735.18 AMD20560.1 - 0.034 13.4 0.0 0.91 8.7 0.0 2.5 3 0 0 3 3 3 0 Septin RNA_helicase PF00910.22 AMD20560.1 - 0.04 14.3 0.0 3.2 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase EF-hand_10 PF14788.6 AMD20560.1 - 0.048 13.5 0.2 2.8 7.9 0.0 2.6 2 0 0 2 2 2 0 EF hand AAA_23 PF13476.6 AMD20560.1 - 0.072 13.6 0.1 0.42 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Toprim PF01751.22 AMD20560.1 - 0.083 13.1 0.0 1.3 9.3 0.0 2.9 3 1 0 3 3 3 0 Toprim domain G-alpha PF00503.20 AMD20560.1 - 0.092 11.9 0.0 0.86 8.7 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_15 PF13175.6 AMD20560.1 - 0.1 12.3 0.9 0.77 9.4 0.1 2.6 2 1 0 3 3 3 0 AAA ATPase domain AAA_24 PF13479.6 AMD20560.1 - 0.17 11.6 0.0 1.9 8.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain SPARC_Ca_bdg PF10591.9 AMD20560.1 - 0.18 12.2 3.8 44 4.4 0.2 3.6 4 0 0 4 4 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 AMD20560.1 - 0.54 10.1 3.2 11 6.0 0.1 3.2 3 0 0 3 3 3 0 EF-hand domain pair Zn_clus PF00172.18 AMD20561.1 - 6.3e-11 42.2 13.6 1.4e-10 41.1 13.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BLI1 PF17324.2 AMD20561.1 - 1.1 9.9 4.4 1.3 9.7 1.0 2.5 2 0 0 2 2 2 0 BLOC-1 interactor 1 Zn_clus PF00172.18 AMD20562.1 - 3e-08 33.6 10.4 6e-08 32.7 10.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 AMD20563.1 - 2.2e-10 40.5 6.6 4.6e-10 39.5 6.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRP PF06011.12 AMD20564.1 - 3.5e-152 507.1 27.8 4.3e-152 506.8 27.8 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 AMD20564.1 - 6.1e-35 120.6 2.9 1.1e-34 119.8 2.9 1.4 1 0 0 1 1 1 1 ML-like domain AMP-binding PF00501.28 AMD20565.1 - 1.3e-89 300.7 0.1 1.6e-89 300.5 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AMD20565.1 - 5e-21 75.5 0.0 1.4e-20 74.0 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AMD20565.1 - 3.2e-16 59.0 0.2 7.2e-16 57.8 0.2 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus MHC_II_beta PF00969.19 AMD20565.1 - 0.027 14.6 0.0 0.062 13.4 0.0 1.6 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain CH PF00307.31 AMD20566.1 - 2.8e-14 53.2 0.0 4.1e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Peroxin-22 PF12827.7 AMD20567.1 - 4.6e-20 71.6 0.0 6.2e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family Rad1 PF02144.16 AMD20568.1 - 2.5e-61 207.2 1.8 2.5e-61 207.2 1.8 1.6 2 0 0 2 2 2 1 Repair protein Rad1/Rec1/Rad17 Ribosomal_L7Ae PF01248.26 AMD20569.1 - 1.2e-19 69.9 0.1 1.6e-19 69.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family GDI PF00996.18 AMD20570.1 - 7.8e-44 149.9 0.0 3.8e-43 147.6 0.0 1.8 1 1 0 1 1 1 1 GDP dissociation inhibitor DUF1749 PF08538.10 AMD20570.1 - 0.02 14.0 0.4 0.042 12.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Kelch_4 PF13418.6 AMD20571.1 - 3.5e-09 36.5 1.8 0.00026 20.9 0.1 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.6 AMD20571.1 - 6.5e-07 29.5 0.0 0.064 13.6 0.0 4.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 AMD20571.1 - 1e-06 28.8 2.5 0.015 15.6 0.1 4.3 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 AMD20571.1 - 2e-05 24.4 0.5 11 6.1 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 AMD20571.1 - 2.3e-05 23.9 0.3 0.018 14.6 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 AMD20571.1 - 2.6e-05 24.0 1.4 0.11 12.5 0.4 3.3 3 0 0 3 3 3 2 Kelch motif LRR_4 PF12799.7 AMD20573.1 - 4.4e-11 42.8 46.3 0.00033 21.0 0.3 7.8 5 1 5 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AMD20573.1 - 6.5e-06 25.8 39.4 0.0015 18.2 4.5 7.0 3 2 4 7 7 7 4 Leucine rich repeat LRR_6 PF13516.6 AMD20573.1 - 5e-05 23.0 30.2 0.21 11.7 0.1 8.1 9 0 0 9 9 9 4 Leucine Rich repeat LRR_9 PF14580.6 AMD20573.1 - 0.41 10.1 11.7 0.75 9.3 0.1 3.7 2 1 1 3 3 3 0 Leucine-rich repeat FNIP PF05725.12 AMD20573.1 - 3.3 7.9 11.5 14 6.0 1.9 4.0 4 0 0 4 4 4 0 FNIP Repeat TrbI PF03743.14 AMD20574.1 - 0.0018 18.1 0.0 0.0033 17.3 0.0 1.3 1 1 0 1 1 1 1 Bacterial conjugation TrbI-like protein Alb1 PF09135.11 AMD20575.1 - 6.5e-25 88.0 11.0 6.5e-25 88.0 11.0 1.7 2 0 0 2 2 2 1 Alb1 BRCT PF00533.26 AMD20575.1 - 0.0073 16.7 0.2 0.015 15.6 0.2 1.7 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PKI PF02827.16 AMD20575.1 - 2 8.7 7.4 2.9 8.2 0.7 2.5 2 1 0 2 2 2 0 cAMP-dependent protein kinase inhibitor SNO PF01174.19 AMD20576.1 - 7.2e-69 231.4 0.0 8.2e-69 231.2 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 AMD20576.1 - 3.1e-09 36.7 0.0 7.3e-09 35.5 0.0 1.6 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 AMD20576.1 - 2.3e-05 24.2 0.0 2.9e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ThiJ_like PF17124.5 AMD20576.1 - 0.0092 15.7 0.0 0.017 14.8 0.0 1.5 1 1 1 2 2 2 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 AMD20576.1 - 0.017 14.9 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family SOR_SNZ PF01680.17 AMD20577.1 - 4.2e-104 346.8 4.1 5.6e-104 346.4 4.1 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 AMD20577.1 - 8.2e-09 35.1 1.9 5e-07 29.3 0.0 2.6 2 1 0 2 2 2 1 Thiazole biosynthesis protein ThiG TetR_C_27 PF17935.1 AMD20577.1 - 0.0073 16.4 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain His_biosynth PF00977.21 AMD20577.1 - 0.0081 15.6 0.3 0.14 11.6 0.0 2.5 2 1 1 3 3 3 1 Histidine biosynthesis protein NanE PF04131.14 AMD20577.1 - 0.0082 15.4 0.4 0.074 12.2 0.0 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 AMD20577.1 - 0.0099 15.1 0.0 0.047 12.8 0.0 2.0 3 0 0 3 3 3 1 Indole-3-glycerol phosphate synthase Dus PF01207.17 AMD20577.1 - 0.013 14.6 0.2 1.9 7.5 0.0 2.6 2 1 1 3 3 3 0 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 AMD20577.1 - 0.018 14.3 0.2 0.17 11.2 0.1 2.3 2 0 0 2 2 2 0 Thiamine monophosphate synthase NMO PF03060.15 AMD20577.1 - 0.022 14.1 0.9 0.13 11.6 0.1 2.1 2 0 0 2 2 2 0 Nitronate monooxygenase FMN_dh PF01070.18 AMD20577.1 - 0.08 12.0 0.0 0.18 10.8 0.0 1.6 1 1 0 1 1 1 0 FMN-dependent dehydrogenase Sigma70_r3 PF04539.16 AMD20577.1 - 0.1 12.7 0.9 18 5.5 0.1 2.4 2 0 0 2 2 2 0 Sigma-70 region 3 RRM_1 PF00076.22 AMD20578.1 - 0.0001 22.0 0.0 0.016 15.1 0.0 2.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tau95 PF09734.9 AMD20578.1 - 6.9 7.5 7.8 1.5 9.6 1.7 2.3 2 0 0 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain NGP1NT PF08153.12 AMD20579.1 - 2.9e-50 169.8 0.1 4.8e-50 169.1 0.1 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 AMD20579.1 - 1.1e-17 64.2 0.0 1.4e-13 50.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD20579.1 - 1.3e-05 24.8 0.0 5.4e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AMD20579.1 - 0.0017 18.3 0.0 0.0042 17.0 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 AMD20579.1 - 0.0022 17.5 0.1 0.26 10.7 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AMD20579.1 - 0.0069 15.9 0.0 0.6 9.6 0.0 3.0 2 1 0 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AMD20579.1 - 0.007 16.4 4.1 0.81 9.7 0.0 3.6 3 1 1 4 4 4 1 Dynamin family SusD-like_3 PF14322.6 AMD20579.1 - 0.042 14.2 0.0 0.073 13.4 0.0 1.3 1 0 0 1 1 1 0 Starch-binding associating with outer membrane CAF1 PF04857.20 AMD20580.1 - 1.7e-12 47.1 0.1 1.7e-08 34.0 0.0 2.3 2 0 0 2 2 2 2 CAF1 family ribonuclease OKR_DC_1_C PF03711.15 AMD20580.1 - 0.094 13.0 0.1 0.26 11.6 0.1 1.7 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, C-terminal domain NTF2 PF02136.20 AMD20581.1 - 1.1e-20 74.3 2.0 2e-20 73.6 0.2 2.1 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 AMD20581.1 - 0.0014 18.4 0.0 0.004 16.9 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Y_phosphatase2 PF03162.13 AMD20582.1 - 4.8e-34 117.3 2.3 4.1e-32 111.0 2.3 2.3 1 1 0 1 1 1 1 Tyrosine phosphatase family Sacchrp_dh_C PF16653.5 AMD20583.1 - 6.7e-82 275.6 0.0 9e-82 275.1 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 AMD20583.1 - 7.2e-24 84.5 0.4 1.3e-23 83.7 0.4 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 AMD20583.1 - 4.3e-09 36.5 0.2 9.7e-09 35.4 0.1 1.6 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 AMD20583.1 - 5.3e-07 29.7 0.1 8.7e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 AMD20583.1 - 2.6e-05 24.7 0.5 7.4e-05 23.3 0.3 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 AMD20583.1 - 6.4e-05 23.2 0.8 0.00011 22.5 0.8 1.4 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.19 AMD20583.1 - 0.00048 19.2 0.1 0.00072 18.7 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_3 PF03447.16 AMD20583.1 - 0.0057 17.3 0.2 0.0096 16.6 0.2 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Epimerase PF01370.21 AMD20583.1 - 0.0096 15.4 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2325 PF10087.9 AMD20583.1 - 0.049 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) Semialdhyde_dh PF01118.24 AMD20583.1 - 0.099 13.1 0.1 0.28 11.6 0.1 1.8 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 AMD20583.1 - 0.14 11.4 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mso1_Sec1_bdg PF14475.6 AMD20584.1 - 1.5e-18 66.1 0.2 4.2e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 Sec1-binding region of Mso1 Not1 PF04054.15 AMD20585.1 - 1.9e-132 441.6 2.4 1.9e-132 441.6 2.4 3.6 3 0 0 3 3 2 1 CCR4-Not complex component, Not1 CNOT1_HEAT_N PF16419.5 AMD20585.1 - 6.2e-86 287.8 7.1 6.2e-86 287.8 7.1 2.9 2 0 0 2 2 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_CAF1_bind PF16415.5 AMD20585.1 - 1.6e-85 286.1 2.4 1.6e-85 286.1 2.4 2.6 2 0 0 2 2 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 AMD20585.1 - 1.6e-43 148.2 6.1 1.6e-43 148.2 6.1 4.0 2 1 0 2 2 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 AMD20585.1 - 1.4e-39 135.3 0.2 1.4e-39 135.3 0.2 4.8 3 1 0 3 3 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 AMD20585.1 - 1.8e-13 50.8 0.1 1.8e-13 50.8 0.1 6.3 4 1 0 4 4 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat Presenilin PF01080.17 AMD20585.1 - 2.5e-06 26.5 29.7 6.3e-06 25.2 29.7 1.6 1 0 0 1 1 1 1 Presenilin Band_3_cyto PF07565.13 AMD20585.1 - 0.0029 17.5 22.8 0.0029 17.5 22.8 2.4 2 0 0 2 2 2 1 Band 3 cytoplasmic domain PAT1 PF09770.9 AMD20585.1 - 0.29 9.4 70.1 0.0037 15.6 55.3 2.2 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 BAF1_ABF1 PF04684.13 AMD20585.1 - 0.32 10.0 29.4 0.57 9.2 29.4 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor POR PF01558.18 AMD20585.1 - 0.33 11.0 1.1 2 8.5 0.2 2.3 2 0 0 2 2 2 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Ndc1_Nup PF09531.10 AMD20585.1 - 0.42 9.3 33.0 0.094 11.4 24.2 2.4 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Pkinase_fungal PF17667.1 AMD20585.1 - 0.58 8.9 14.5 1.4 7.6 14.5 1.6 1 0 0 1 1 1 0 Fungal protein kinase Asp-B-Hydro_N PF05279.11 AMD20585.1 - 0.93 9.5 24.8 1.9 8.5 24.8 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TT_ORF1 PF02956.14 AMD20585.1 - 4.9 5.7 26.2 10 4.7 26.2 1.4 1 0 0 1 1 1 0 TT viral orf 1 DUF572 PF04502.13 AMD20585.1 - 5.9 6.4 30.0 16 5.0 30.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF572) CDC50 PF03381.15 AMD20586.1 - 8.5e-92 307.6 0.1 1e-91 307.4 0.1 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family UQ_con PF00179.26 AMD20587.1 - 2.6e-42 143.8 0.0 3.3e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 AMD20587.1 - 1.7e-27 94.9 2.7 2.8e-27 94.3 2.7 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Calsarcin PF05556.11 AMD20587.1 - 0.014 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) HTH_37 PF13744.6 AMD20587.1 - 0.058 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1421 PF07223.11 AMD20587.1 - 0.11 12.3 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 UBA-like domain (DUF1421) GGA_N-GAT PF18308.1 AMD20587.1 - 0.29 10.8 2.2 3.1 7.5 0.3 2.5 2 0 0 2 2 2 0 GGA N-GAT domain MutS_V PF00488.21 AMD20588.1 - 1.3e-65 221.0 0.0 3.3e-65 219.7 0.0 1.8 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AMD20588.1 - 6.1e-37 127.7 3.4 6.9e-37 127.5 1.5 2.2 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 AMD20588.1 - 3.8e-28 98.0 0.1 8.1e-28 96.9 0.1 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 AMD20588.1 - 2.7e-08 34.2 0.3 3.5e-07 30.6 0.0 2.7 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 AMD20588.1 - 1.4e-06 28.5 0.3 1.4e-06 28.5 0.3 2.4 2 0 0 2 2 2 1 MutS family domain IV Glyco_hydro_72 PF03198.14 AMD20588.1 - 0.088 12.0 2.1 0.26 10.5 0.3 2.2 2 0 0 2 2 2 0 Glucanosyltransferase AAA_27 PF13514.6 AMD20588.1 - 0.091 12.3 0.1 0.58 9.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.6 AMD20588.1 - 0.17 11.9 1.6 1.5 8.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain FerA PF08165.11 AMD20588.1 - 6.1 6.9 6.3 1.4 8.9 0.5 2.8 3 0 0 3 3 3 0 FerA (NUC095) domain KELK PF15796.5 AMD20588.1 - 7.9 7.0 10.5 0.47 10.9 0.2 3.3 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase PF00069.25 AMD20589.1 - 6.6e-77 258.4 0.0 9.5e-77 257.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20589.1 - 9.1e-32 110.3 0.0 4.3e-30 104.9 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20589.1 - 3.7e-07 29.8 0.1 0.00012 21.5 0.0 2.4 1 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AMD20589.1 - 0.00095 18.0 0.0 0.0028 16.5 0.0 1.7 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AMD20589.1 - 0.05 12.9 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Trm112p PF03966.16 AMD20590.1 - 7.3e-19 68.1 0.1 9.3e-19 67.8 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein Thiolase_N PF00108.23 AMD20591.1 - 3.5e-91 305.2 3.6 4.3e-91 304.9 3.6 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AMD20591.1 - 8.7e-45 151.3 0.4 8.7e-45 151.3 0.4 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AMD20591.1 - 1.1e-06 28.4 4.1 3.9e-06 26.7 4.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thymosin PF01290.20 AMD20591.1 - 0.22 11.3 0.1 0.42 10.4 0.1 1.4 1 0 0 1 1 1 0 Thymosin beta-4 family SKI PF01202.22 AMD20592.1 - 7.2e-12 45.7 0.0 8.3e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 AMD20592.1 - 1e-09 38.7 0.0 1.3e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 AMD20592.1 - 8.9e-09 35.4 0.0 1.1e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 AMD20592.1 - 4.7e-07 30.4 0.0 5e-06 27.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AMD20592.1 - 3.3e-06 27.6 0.0 5.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 AMD20592.1 - 1.3e-05 25.1 0.1 2.3e-05 24.3 0.1 1.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Cytidylate_kin2 PF13189.6 AMD20592.1 - 4.6e-05 23.6 0.0 0.0024 18.0 0.0 2.2 2 0 0 2 2 2 1 Cytidylate kinase-like family Cytidylate_kin PF02224.18 AMD20592.1 - 0.00021 21.1 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 Cytidylate kinase Thymidylate_kin PF02223.17 AMD20592.1 - 0.00048 19.9 0.0 0.23 11.1 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase PRK PF00485.18 AMD20592.1 - 0.00093 19.0 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family dNK PF01712.19 AMD20592.1 - 0.002 18.0 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 1 Deoxynucleoside kinase AAA_16 PF13191.6 AMD20592.1 - 0.0033 17.8 0.0 0.0065 16.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 AMD20592.1 - 0.0034 16.7 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 AMD20592.1 - 0.0042 17.4 0.0 0.01 16.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AMD20592.1 - 0.0076 16.2 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 AMD20592.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 AMD20592.1 - 0.02 14.9 0.0 4.8 7.2 0.0 2.2 1 1 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 AMD20592.1 - 0.025 14.5 0.0 0.32 10.9 0.0 2.1 2 1 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_25 PF13481.6 AMD20592.1 - 0.041 13.4 1.0 0.13 11.8 0.4 2.0 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 AMD20592.1 - 0.044 14.0 0.0 0.098 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 AMD20592.1 - 0.044 14.3 0.0 0.073 13.6 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Ploopntkinase1 PF18748.1 AMD20592.1 - 0.072 12.6 0.0 6 6.3 0.0 2.2 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 NACHT PF05729.12 AMD20592.1 - 0.076 12.9 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 AMD20592.1 - 0.081 12.1 0.0 0.25 10.5 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 AMD20592.1 - 0.089 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 AMD20592.1 - 0.091 13.2 0.0 0.12 12.8 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 AMD20592.1 - 0.094 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CoaE PF01121.20 AMD20592.1 - 0.098 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase CbiA PF01656.23 AMD20592.1 - 0.1 12.6 0.1 0.1 12.6 0.1 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 AMD20592.1 - 0.11 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 AMD20592.1 - 0.13 12.7 0.0 0.3 11.5 0.0 1.6 2 0 0 2 2 1 0 RNA helicase AAA_24 PF13479.6 AMD20592.1 - 0.16 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 AMD20593.1 - 3.7e-46 157.6 0.1 8.7e-41 140.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20593.1 - 7.6e-20 71.3 0.1 1.4e-18 67.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20593.1 - 5.6e-05 22.6 0.0 8.8e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD20593.1 - 0.00052 20.0 0.1 0.00079 19.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 AMD20593.1 - 0.019 13.9 0.4 0.033 13.2 0.4 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FTA2 PF13095.6 AMD20593.1 - 0.059 13.0 0.1 9 5.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YukC PF10140.9 AMD20593.1 - 0.16 10.8 0.0 0.16 10.8 0.0 1.5 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC p450 PF00067.22 AMD20594.1 - 6.5e-98 328.5 0.0 7.5e-98 328.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_25 PF13649.6 AMD20595.1 - 0.15 12.8 0.0 0.49 11.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Sod_Fe_C PF02777.18 AMD20596.1 - 2e-34 117.8 0.4 3.9e-34 116.9 0.4 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 AMD20596.1 - 1.7e-25 89.3 2.6 3.6e-25 88.2 2.6 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Phos_pyr_kin PF08543.12 AMD20597.1 - 4.3e-11 42.7 0.0 5.6e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 AMD20597.1 - 3.7e-05 23.2 0.0 5.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CDC27 PF09507.10 AMD20598.1 - 0.0002 20.9 42.1 0.0043 16.5 39.4 2.8 2 1 0 2 2 2 2 DNA polymerase subunit Cdc27 CST-I PF06002.12 AMD20598.1 - 0.044 13.5 0.9 0.057 13.2 0.0 1.6 2 0 0 2 2 2 0 Alpha-2,3-sialyltransferase (CST-I) ATP-synt_C PF00137.21 AMD20599.1 - 1.6e-34 118.0 31.6 2.2e-22 79.1 13.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Tetraspanin PF00335.20 AMD20599.1 - 3.8 7.2 7.9 7 6.3 7.9 1.4 1 0 0 1 1 1 0 Tetraspanin family DUF2970 PF11174.8 AMD20599.1 - 4.3 7.3 10.4 0.87 9.5 1.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Nucleopor_Nup85 PF07575.13 AMD20600.1 - 2.2e-180 601.0 16.2 2.6e-180 600.8 16.2 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin Urb2 PF10441.9 AMD20601.1 - 1.1e-53 182.2 1.0 3.5e-53 180.6 1.0 2.0 1 0 0 1 1 1 1 Urb2/Npa2 family Voltage_CLC PF00654.20 AMD20602.1 - 6.2e-79 265.8 22.8 6.2e-79 265.8 22.8 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 AMD20602.1 - 1.1e-13 51.4 0.0 5e-07 30.1 0.0 2.5 2 0 0 2 2 2 2 CBS domain Ribosomal_L7Ae PF01248.26 AMD20603.1 - 7.9e-27 92.8 0.1 9.5e-27 92.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 AMD20603.1 - 0.0031 17.4 0.0 0.0043 16.9 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 AMD20603.1 - 0.0043 17.1 0.0 0.0045 17.0 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Pico_P2B PF01552.17 AMD20603.1 - 0.053 13.7 0.1 0.11 12.7 0.0 1.5 1 1 1 2 2 2 0 Picornavirus 2B protein HECT PF00632.25 AMD20606.1 - 1.9e-82 277.2 2.2 1.9e-82 277.2 2.2 2.2 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Tuberin PF03542.16 AMD20606.1 - 0.017 14.3 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 Tuberin UCR_TM PF02921.14 AMD20607.1 - 2e-11 44.2 1.8 4.7e-11 43.0 1.8 1.7 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 AMD20607.1 - 2.8e-11 43.2 0.0 4.9e-11 42.4 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Transp_cyt_pur PF02133.15 AMD20607.1 - 0.12 11.1 0.2 0.15 10.8 0.2 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2235 PF09994.9 AMD20608.1 - 1e-79 267.9 0.0 1.4e-79 267.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SNF2_N PF00176.23 AMD20609.1 - 1e-73 248.1 0.1 1.9e-73 247.2 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD20609.1 - 4.4e-21 75.3 1.7 1.4e-20 73.7 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD20609.1 - 4.8e-07 29.9 0.0 4.8e-07 29.9 0.0 3.3 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit HeLo PF14479.6 AMD20609.1 - 0.0074 16.1 2.1 0.0074 16.1 2.1 2.3 2 1 0 2 2 2 1 Prion-inhibition and propagation BLOC1_2 PF10046.9 AMD20609.1 - 0.058 13.7 5.7 0.049 13.9 2.0 2.8 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Snapin_Pallidin PF14712.6 AMD20609.1 - 0.16 12.4 10.4 0.041 14.3 4.7 2.6 1 1 1 2 2 2 0 Snapin/Pallidin Csm1_N PF18504.1 AMD20609.1 - 1.7 9.1 7.2 1.9 8.9 1.1 3.1 1 1 1 2 2 2 0 Csm1 N-terminal domain Pet191_N PF10203.9 AMD20610.1 - 3.8e-24 84.8 4.3 5.3e-24 84.3 4.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 AMD20610.1 - 0.25 11.4 3.3 7.1 6.7 0.1 2.6 2 1 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 AMD20610.1 - 0.31 11.2 2.9 0.72 10.1 0.4 2.5 2 0 0 2 2 2 0 CHCH domain CX9C PF16860.5 AMD20610.1 - 1 9.4 7.2 7.3 6.7 0.5 3.1 2 1 1 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Rav1p_C PF12234.8 AMD20611.1 - 3.1e-232 772.6 7.9 3.6e-232 772.3 4.7 2.1 2 0 0 2 2 2 2 RAVE protein 1 C terminal Pro_isomerase PF00160.21 AMD20612.1 - 5.7e-41 140.4 0.1 8.4e-41 139.9 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 AMD20612.1 - 6e-09 35.3 6.7 1.6e-07 30.8 0.3 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 AMD20612.1 - 2.8e-08 33.3 5.2 2.9e-06 27.0 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 AMD20612.1 - 8.2e-06 25.6 6.7 0.0001 22.2 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 AMD20612.1 - 0.00076 19.7 0.0 0.0036 17.6 0.0 2.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 AMD20612.1 - 0.03 15.0 0.0 0.052 14.2 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AMD20612.1 - 1.8 8.7 3.8 3.4 7.8 0.1 3.2 4 1 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Sec7 PF01369.20 AMD20613.1 - 1.9e-67 226.5 0.3 4.2e-67 225.4 0.3 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 AMD20613.1 - 2.9e-16 59.8 0.4 2.9e-16 59.8 0.4 4.3 4 2 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 AMD20613.1 - 1.2e-06 28.3 16.9 1.3e-06 28.2 2.2 3.7 4 0 0 4 4 4 2 Dimerisation and cyclophilin-binding domain of Mon2 Mito_carr PF00153.27 AMD20614.1 - 5.9e-14 51.8 1.5 6.4e-09 35.6 0.1 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein OMPdecase PF00215.24 AMD20615.1 - 3.5e-75 252.5 0.0 4e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family zf-Tim10_DDP PF02953.15 AMD20616.1 - 4.9e-20 70.9 5.3 4.9e-20 70.9 5.3 1.4 1 1 0 1 1 1 1 Tim10/DDP family zinc finger Phasin_2 PF09361.10 AMD20616.1 - 0.01 16.1 0.1 0.18 12.1 0.0 2.1 1 1 1 2 2 2 0 Phasin protein Hormone_recep PF00104.30 AMD20616.1 - 0.04 13.5 2.7 0.042 13.4 2.7 1.1 1 0 0 1 1 1 0 Ligand-binding domain of nuclear hormone receptor Tam41_Mmp37 PF09139.11 AMD20616.1 - 0.076 12.4 0.4 0.081 12.3 0.4 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial TPP_enzyme_N PF02776.18 AMD20618.1 - 1.6e-38 132.1 0.0 2.6e-38 131.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AMD20618.1 - 1.2e-23 83.4 0.0 2.6e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AMD20618.1 - 1.8e-22 79.8 0.0 5.6e-22 78.2 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 AMD20618.1 - 0.0062 15.8 0.2 0.01 15.0 0.2 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase tRNA-synt_2 PF00152.20 AMD20619.1 - 1.8e-75 253.9 0.0 2.4e-75 253.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AMD20619.1 - 1.9e-08 34.2 0.0 3.7e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AMD20619.1 - 0.0026 17.3 0.1 0.56 9.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 AMD20619.1 - 0.017 15.1 0.0 0.11 12.5 0.0 2.3 2 1 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) DUF2982 PF11201.8 AMD20619.1 - 0.038 13.6 0.1 0.075 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2982) zf-Nse PF11789.8 AMD20620.1 - 1.2e-18 66.7 0.3 2.8e-18 65.5 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 AMD20620.1 - 4.6e-09 36.1 1.3 1.3e-08 34.7 1.3 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AMD20620.1 - 2.6e-05 23.9 0.4 6.8e-05 22.6 0.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 AMD20620.1 - 0.0001 21.7 0.5 0.005 16.2 0.0 2.1 2 0 0 2 2 2 1 Rtf2 RING-finger U-box PF04564.15 AMD20620.1 - 0.00022 21.3 0.1 0.00063 19.9 0.1 1.8 2 0 0 2 2 2 1 U-box domain zf-RING_2 PF13639.6 AMD20620.1 - 0.00047 20.4 0.6 0.001 19.3 0.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-MIZ PF02891.20 AMD20620.1 - 0.0049 16.6 1.2 0.008 15.9 0.6 1.8 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-C3HC4 PF00097.25 AMD20620.1 - 0.013 15.3 0.1 0.031 14.1 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AMD20620.1 - 0.043 14.1 0.2 0.14 12.5 0.1 1.9 2 0 0 2 2 2 0 RING-H2 zinc finger domain TACC_C PF05010.14 AMD20621.1 - 0.0074 16.1 1.9 0.86 9.4 0.8 2.2 2 0 0 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DNA_pol_phi PF04931.13 AMD20622.1 - 0.55 8.3 4.1 0.7 7.9 4.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 AMD20622.1 - 1.2 7.4 2.8 1.6 7.0 2.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Phosphodiest PF01663.22 AMD20623.1 - 2.6e-77 260.8 2.1 3.2e-77 260.5 2.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 AMD20623.1 - 0.00011 21.7 0.2 0.00025 20.6 0.2 1.5 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.17 AMD20623.1 - 0.0068 15.1 0.0 0.015 13.9 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF229) Rhodanese PF00581.20 AMD20623.1 - 0.042 14.4 0.2 0.71 10.4 0.1 2.3 1 1 1 2 2 2 0 Rhodanese-like domain PglZ PF08665.12 AMD20623.1 - 0.18 11.9 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 PglZ domain YjeF_N PF03853.15 AMD20624.1 - 5.2e-28 98.1 0.1 9.2e-28 97.3 0.1 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 AMD20624.1 - 1.5e-08 35.5 1.3 4.2e-08 34.0 1.3 1.8 1 0 0 1 1 1 1 FDF domain Arm PF00514.23 AMD20625.1 - 1e-70 231.8 30.4 1.4e-11 44.0 0.0 11.3 11 1 0 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 AMD20625.1 - 2e-21 76.0 11.8 0.00013 22.4 0.3 7.5 6 1 1 7 7 7 6 HEAT-like repeat HEAT_2 PF13646.6 AMD20625.1 - 6e-16 58.6 5.0 0.0072 16.7 0.0 6.4 3 2 3 6 6 6 4 HEAT repeats HEAT PF02985.22 AMD20625.1 - 2.8e-14 52.0 13.8 0.04 14.2 0.1 9.1 8 0 0 8 8 8 4 HEAT repeat Adaptin_N PF01602.20 AMD20625.1 - 2.7e-11 42.7 14.1 1.4e-08 33.8 3.7 2.3 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 AMD20625.1 - 6e-10 39.0 10.1 1.5e-08 34.5 2.9 2.7 1 1 1 2 2 2 2 Armadillo-like KAP PF05804.12 AMD20625.1 - 2.1e-08 32.8 1.4 7.5e-08 31.0 1.4 2.0 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 AMD20625.1 - 7.2e-06 25.5 7.2 0.00065 19.1 1.0 3.6 1 1 1 2 2 2 1 V-ATPase subunit H Cnd1 PF12717.7 AMD20625.1 - 1.3e-05 25.3 13.3 0.056 13.5 0.3 5.4 1 1 3 6 6 6 3 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 AMD20625.1 - 1.8e-05 24.7 15.0 0.0027 17.7 0.3 4.9 2 2 3 5 5 5 1 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 AMD20625.1 - 3.3e-05 24.0 6.0 0.0075 16.4 0.1 5.0 2 2 3 6 6 6 1 V-ATPase subunit H Tti2 PF10521.9 AMD20625.1 - 0.00047 19.8 0.0 0.16 11.5 0.0 3.3 3 0 0 3 3 3 1 Tti2 family Vac14_Fab1_bd PF12755.7 AMD20625.1 - 0.00091 19.8 0.4 2.4 8.8 0.0 3.6 2 1 0 3 3 3 2 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 AMD20625.1 - 0.059 13.6 4.5 29 4.9 0.0 5.5 4 2 3 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 LSM PF01423.22 AMD20626.1 - 3e-10 39.6 0.1 3.9e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AMD20626.1 - 0.011 15.9 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain UQ_con PF00179.26 AMD20628.1 - 4e-39 133.5 0.1 5.8e-39 132.9 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme F-protein PF00469.20 AMD20628.1 - 0.053 13.1 2.2 0.074 12.6 2.2 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Alpha-amylase_C PF02806.18 AMD20629.1 - 5.8e-24 84.4 0.1 1.7e-23 82.9 0.1 1.9 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 AMD20629.1 - 7.6e-15 55.0 0.1 3e-14 53.1 0.1 2.1 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 AMD20629.1 - 3.8e-13 49.7 0.2 2.9e-12 46.8 0.1 2.2 1 1 1 2 2 2 1 Alpha amylase, catalytic domain ANAPC_CDC26 PF10471.9 AMD20630.1 - 5e-13 49.7 2.5 5e-13 49.7 2.5 1.5 1 1 1 2 2 2 2 Anaphase-promoting complex APC subunit CDC26 MMgT PF10270.9 AMD20631.1 - 3.2e-26 91.6 0.1 4.6e-26 91.1 0.1 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter STAG PF08514.11 AMD20632.1 - 7e-28 96.8 0.9 3e-27 94.8 0.9 2.2 1 0 0 1 1 1 1 STAG domain Cnd1 PF12717.7 AMD20632.1 - 0.00017 21.7 1.5 0.18 11.8 0.0 3.8 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 AMD20632.1 - 0.00097 19.2 2.9 0.055 13.8 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 AMD20632.1 - 0.034 14.5 0.0 1.2 9.6 0.0 3.3 3 1 0 3 3 3 0 HEAT repeats DUF4745 PF15923.5 AMD20632.1 - 0.11 12.5 6.1 18 5.3 0.1 4.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4745) AMPK1_CBM PF16561.5 AMD20633.1 - 0.00037 20.7 1.0 0.001 19.3 1.0 1.7 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Plasmodium_HRP PF05403.11 AMD20633.1 - 0.14 12.0 0.8 0.66 9.7 0.5 2.0 2 0 0 2 2 2 0 Plasmodium histidine-rich protein (HRPII/III) RimM PF01782.18 AMD20633.1 - 0.97 9.7 5.4 13 6.1 0.4 3.3 2 1 1 3 3 3 0 RimM N-terminal domain MFS_1 PF07690.16 AMD20634.1 - 3.9e-32 111.5 26.2 3.9e-32 111.5 26.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AMD20634.1 - 5.8e-07 28.7 35.8 3.9e-06 26.0 13.8 2.2 1 1 0 2 2 2 2 Sugar (and other) transporter Zip PF02535.22 AMD20635.1 - 2.2e-32 112.6 11.8 4.1e-30 105.1 2.3 2.3 3 0 0 3 3 3 2 ZIP Zinc transporter Rick_17kDa_Anti PF05433.15 AMD20635.1 - 0.12 12.3 0.6 0.44 10.4 0.6 2.0 1 0 0 1 1 1 0 Glycine zipper 2TM domain CN_hydrolase PF00795.22 AMD20635.1 - 0.17 11.2 0.1 1.4 8.2 0.1 2.0 2 0 0 2 2 2 0 Carbon-nitrogen hydrolase SWIRM PF04433.17 AMD20636.1 - 2.2e-29 101.6 0.5 8.4e-29 99.8 0.5 2.1 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 AMD20636.1 - 8.4e-11 41.5 2.8 1.4e-10 40.8 2.8 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM-assoc_1 PF16495.5 AMD20636.1 - 2.7e-10 40.1 1.8 2.7e-10 40.1 1.8 2.7 3 0 0 3 3 3 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 AMD20636.1 - 4.3e-09 36.4 0.1 1e-08 35.2 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD20636.1 - 2.8e-06 27.5 0.4 1.4e-05 25.2 0.1 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-UBR PF02207.20 AMD20636.1 - 0.013 15.6 1.7 0.026 14.7 1.7 1.4 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-CCHC_2 PF13696.6 AMD20636.1 - 0.037 13.9 3.5 0.68 9.8 0.2 2.3 2 0 0 2 2 2 0 Zinc knuckle Elf1 PF05129.13 AMD20636.1 - 0.099 12.7 0.3 0.24 11.5 0.3 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like SNF2_N PF00176.23 AMD20637.1 - 6.5e-64 215.9 0.1 1.7e-63 214.5 0.1 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD20637.1 - 1.2e-21 77.2 0.0 1.6e-20 73.5 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD20637.1 - 8e-09 35.7 0.0 4.5e-08 33.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AMD20637.1 - 0.00021 21.1 0.0 0.00047 20.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase cNMP_binding PF00027.29 AMD20638.1 - 1.5e-42 143.5 0.2 1.8e-20 72.8 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 AMD20638.1 - 1.7e-08 34.0 3.3 1.8e-08 33.9 1.3 2.1 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.11 AMD20638.1 - 1.7 8.4 3.4 12 5.7 0.1 2.4 2 0 0 2 2 2 0 Cupin domain Erg28 PF03694.13 AMD20639.1 - 9.8e-46 154.7 0.6 1.2e-45 154.4 0.6 1.1 1 0 0 1 1 1 1 Erg28 like protein DUF308 PF03729.13 AMD20639.1 - 0.011 16.1 0.4 0.036 14.4 0.1 2.0 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) F_actin_cap_B PF01115.17 AMD20640.1 - 5.5e-85 284.8 0.2 6.4e-85 284.6 0.2 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Pkinase PF00069.25 AMD20641.1 - 1.5e-61 208.1 8.0 1.1e-54 185.6 1.1 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20641.1 - 2.6e-20 72.8 3.6 4.7e-16 58.9 0.2 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 AMD20641.1 - 5.3e-07 29.8 0.1 1.4e-05 25.2 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AMD20641.1 - 0.0058 15.5 0.2 0.017 14.0 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AMD20641.1 - 0.01 15.2 0.3 0.021 14.2 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AMD20641.1 - 0.034 13.7 1.0 0.065 12.8 0.1 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase BRICHOS PF04089.14 AMD20642.1 - 0.12 12.7 0.3 0.41 10.9 0.3 2.0 1 1 0 1 1 1 0 BRICHOS domain bZIP_1 PF00170.21 AMD20643.1 - 3.1e-14 52.8 7.9 5e-14 52.1 7.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 AMD20643.1 - 1.4e-07 31.5 11.5 3.2e-07 30.3 11.5 1.5 1 0 0 1 1 1 1 Basic region leucine zipper SAPIS-gp6 PF16722.5 AMD20643.1 - 0.036 14.5 4.8 0.088 13.2 4.8 1.7 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus bZIP_Maf PF03131.17 AMD20643.1 - 0.085 13.4 5.2 0.19 12.3 5.2 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor Rubredoxin PF00301.20 AMD20644.1 - 0.037 14.0 0.5 0.1 12.6 0.5 1.7 1 0 0 1 1 1 0 Rubredoxin Not3 PF04065.15 AMD20646.1 - 2.6e-81 272.4 23.7 2.6e-81 272.4 23.7 2.0 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 AMD20646.1 - 1.8e-21 76.6 2.0 7.4e-21 74.6 2.0 2.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Syntaxin_2 PF14523.6 AMD20646.1 - 0.0035 17.7 3.0 0.0035 17.7 3.0 3.4 3 0 0 3 3 3 1 Syntaxin-like protein Ribosomal_S18 PF01084.20 AMD20646.1 - 0.24 11.6 0.6 0.64 10.3 0.6 1.7 1 0 0 1 1 1 0 Ribosomal protein S18 DUF1192 PF06698.11 AMD20646.1 - 0.38 10.8 6.6 0.49 10.5 1.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) MerR-DNA-bind PF09278.11 AMD20646.1 - 0.57 10.8 4.6 0.58 10.7 0.7 2.7 2 0 0 2 2 2 0 MerR, DNA binding Baculo_F PF12259.8 AMD20646.1 - 1.4 7.3 7.4 1.5 7.2 2.3 2.3 1 1 1 2 2 2 0 Baculovirus F protein AAA PF00004.29 AMD20647.1 - 1e-38 132.7 0.0 3e-38 131.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD20647.1 - 8.3e-08 31.9 0.0 2e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 AMD20647.1 - 1.5e-07 31.3 0.0 1.6e-06 28.0 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.6 AMD20647.1 - 1.3e-05 25.5 0.4 0.00045 20.5 0.1 3.1 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 AMD20647.1 - 0.00012 21.8 0.0 0.00028 20.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 AMD20647.1 - 0.00025 20.4 0.1 0.0033 16.7 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_2 PF07724.14 AMD20647.1 - 0.00052 20.2 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AMD20647.1 - 0.00054 20.0 0.1 0.0025 17.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AMD20647.1 - 0.00088 19.7 0.2 0.0075 16.7 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 AMD20647.1 - 0.0022 18.0 0.0 0.13 12.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 AMD20647.1 - 0.0047 16.3 0.1 0.01 15.2 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 AMD20647.1 - 0.0088 16.6 0.0 0.034 14.7 0.0 2.0 1 0 0 1 1 1 1 ABC transporter IstB_IS21 PF01695.17 AMD20647.1 - 0.0094 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 AMD20647.1 - 0.013 14.7 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 AMD20647.1 - 0.016 15.0 0.1 0.075 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AMD20647.1 - 0.022 14.3 0.0 0.33 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AMD20647.1 - 0.025 14.5 0.2 0.39 10.6 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 AMD20647.1 - 0.033 14.4 0.0 0.085 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AMD20647.1 - 0.055 14.0 0.1 0.24 11.9 0.0 2.3 3 0 0 3 3 1 0 AAA domain TniB PF05621.11 AMD20647.1 - 0.079 12.4 0.0 4.7 6.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 AMD20647.1 - 0.1 12.1 0.0 0.32 10.5 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region Chromo PF00385.24 AMD20647.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain AAA_24 PF13479.6 AMD20647.1 - 0.15 11.8 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 AMD20647.1 - 0.15 11.5 0.0 0.42 10.0 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein Metallophos PF00149.28 AMD20648.1 - 4.9e-05 23.9 5.7 0.00014 22.4 5.7 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DnaJ-X PF14308.6 AMD20649.1 - 2.5e-56 190.4 12.5 5e-56 189.5 7.2 2.4 1 1 1 2 2 2 2 X-domain of DnaJ-containing DnaJ PF00226.31 AMD20649.1 - 1e-24 86.4 2.4 1e-24 86.4 2.4 2.7 3 0 0 3 3 3 1 DnaJ domain DUF3939 PF13075.6 AMD20649.1 - 0.08 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) HSCB_C PF07743.13 AMD20649.1 - 0.17 12.4 5.0 0.52 10.8 5.0 1.9 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain Apq12 PF12716.7 AMD20650.1 - 0.22 11.5 9.7 0.42 10.6 9.7 1.5 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis Complex1_LYR PF05347.15 AMD20651.1 - 1.6e-11 44.1 5.8 2e-11 43.7 5.8 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 AMD20651.1 - 0.0035 18.0 5.7 0.004 17.9 5.7 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Bap31_Bap29_C PF18035.1 AMD20651.1 - 0.018 15.0 0.9 0.032 14.2 0.9 1.4 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain ArsC PF03960.15 AMD20651.1 - 0.064 13.3 0.5 0.083 12.9 0.5 1.2 1 0 0 1 1 1 0 ArsC family Ofd1_CTDD PF10637.9 AMD20652.1 - 6.4e-91 304.2 0.5 5.6e-90 301.1 0.6 2.0 2 0 0 2 2 2 1 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 AMD20652.1 - 6.4e-27 94.1 0.1 2.6e-26 92.1 0.1 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 AMD20652.1 - 3.7e-14 53.4 0.2 1.1e-13 51.9 0.1 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 AMD20652.1 - 0.013 15.9 0.1 0.11 13.0 0.0 2.3 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily BAR_2 PF10455.9 AMD20653.1 - 1.2e-72 244.5 13.3 1.2e-72 244.5 13.3 1.8 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 AMD20653.1 - 9.8e-13 48.3 11.3 9.8e-13 48.3 11.3 2.4 1 1 1 2 2 2 1 BAR domain ATP-synt_ab PF00006.25 AMD20653.1 - 0.043 13.5 0.7 0.81 9.3 0.0 2.4 1 1 1 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DASH_Dad2 PF08654.10 AMD20653.1 - 0.081 13.4 7.6 1 9.8 0.2 3.5 2 1 1 3 3 3 0 DASH complex subunit Dad2 HtaA PF04213.13 AMD20653.1 - 0.14 12.7 1.5 0.57 10.7 0.1 2.4 2 1 0 2 2 2 0 Htaa UPF0223 PF05256.12 AMD20653.1 - 0.21 12.0 5.6 2.1 8.7 0.4 2.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) Tox-REase-5 PF15648.6 AMD20653.1 - 0.38 11.3 3.3 0.54 10.8 0.0 2.6 3 1 0 3 3 3 0 Restriction endonuclease fold toxin 5 Macscav_rec PF03523.13 AMD20653.1 - 0.41 10.6 3.6 5.6 6.9 0.3 3.6 2 1 1 3 3 3 0 Macrophage scavenger receptor DUF3106 PF11304.8 AMD20653.1 - 0.9 10.0 10.4 0.62 10.6 1.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3106) TACC_C PF05010.14 AMD20653.1 - 1.3 8.8 17.0 0.024 14.5 4.7 2.5 1 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Draxin PF15550.6 AMD20653.1 - 2.3 8.0 7.6 0.14 12.0 1.9 1.7 2 1 0 2 2 2 0 Draxin BCDHK_Adom3 PF10436.9 AMD20654.1 - 2.8e-19 69.5 0.7 4.7e-19 68.8 0.7 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AMD20654.1 - 1.8e-13 51.0 0.0 3.8e-13 49.9 0.0 1.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AMD20654.1 - 0.0014 18.4 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S18 PF01084.20 AMD20655.1 - 7.4e-22 77.3 0.0 2.1e-21 75.9 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S18 Tim44 PF04280.15 AMD20656.1 - 1.4e-34 119.3 0.0 3.6e-34 118.0 0.0 1.8 1 0 0 1 1 1 1 Tim44-like domain DUF5132 PF17195.4 AMD20656.1 - 0.01 15.9 0.0 8.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) DUF3496 PF12001.8 AMD20656.1 - 0.094 13.1 0.6 1.1 9.7 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3496) TMEM240 PF15207.6 AMD20657.1 - 0.088 12.5 0.0 0.088 12.5 0.0 1.1 1 0 0 1 1 1 0 TMEM240 family RNA_pol_A_bac PF01000.26 AMD20658.1 - 4.6e-32 110.7 0.3 1.7e-31 108.9 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AMD20658.1 - 2.3e-18 65.4 0.0 3.1e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Big_3_3 PF13750.6 AMD20658.1 - 0.047 13.3 0.1 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Tat PF00539.18 AMD20658.1 - 0.061 13.5 0.3 0.13 12.4 0.3 1.5 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) His_biosynth PF00977.21 AMD20659.1 - 2.4e-28 99.2 0.1 3e-28 98.9 0.1 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF4602 PF15375.6 AMD20660.1 - 4.1e-06 27.2 16.3 0.00017 22.0 4.6 3.1 2 2 1 3 3 3 2 Domain of unknown function (DUF4602) HLH PF00010.26 AMD20661.1 - 1.2e-12 47.5 1.3 4.9e-12 45.6 1.6 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain UCR_hinge PF02320.16 AMD20662.1 - 1.5e-25 89.1 5.0 2.6e-25 88.4 5.0 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein RPN2_C PF18004.1 AMD20662.1 - 0.0044 16.9 0.4 0.0058 16.6 0.4 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 AMD20662.1 - 0.014 13.7 11.0 0.016 13.5 11.0 1.0 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 AMD20662.1 - 0.025 12.7 19.0 0.025 12.7 19.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 AMD20662.1 - 0.041 13.6 14.7 0.048 13.4 14.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.13 AMD20662.1 - 0.053 13.4 11.0 0.065 13.1 11.0 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region GCIP PF13324.6 AMD20662.1 - 0.072 12.7 8.7 0.11 12.1 8.7 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RRN3 PF05327.11 AMD20662.1 - 0.15 10.6 11.0 0.15 10.5 11.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop53 PF07767.11 AMD20662.1 - 0.67 9.3 8.1 0.73 9.2 8.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Sporozoite_P67 PF05642.11 AMD20662.1 - 0.82 7.7 7.7 0.86 7.6 7.7 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 AMD20662.1 - 1.5 7.0 10.7 1.5 7.0 10.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.16 AMD20662.1 - 2.1 7.5 7.4 2.1 7.5 7.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Utp14 PF04615.13 AMD20662.1 - 2.2 6.7 9.2 2.3 6.7 9.2 1.0 1 0 0 1 1 1 0 Utp14 protein CNDH2_C PF16858.5 AMD20662.1 - 2.3 8.0 8.4 2.6 7.9 8.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SDA1 PF05285.12 AMD20662.1 - 4.6 6.6 14.1 4.9 6.5 14.1 1.1 1 0 0 1 1 1 0 SDA1 Ribosomal_L29e PF01779.17 AMD20663.1 - 1.3e-22 79.8 11.3 2e-22 79.2 11.3 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family RRM_1 PF00076.22 AMD20664.1 - 4.6e-18 64.8 0.0 4e-10 39.4 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AMD20664.1 - 6.5e-09 35.5 0.0 0.0021 17.9 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif PepSY_TM PF03929.16 AMD20664.1 - 5.1 6.7 12.9 7.1 6.2 4.8 2.4 2 0 0 2 2 2 0 PepSY-associated TM region Ribosomal_L2_C PF03947.18 AMD20665.1 - 2.3e-44 150.6 4.7 4.1e-44 149.8 4.7 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AMD20665.1 - 2.7e-14 52.9 0.1 7e-14 51.6 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain SMC_N PF02463.19 AMD20666.1 - 4.9e-69 232.1 13.9 1.3e-36 126.1 4.2 3.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AMD20666.1 - 1.7e-18 67.0 0.9 4.9e-18 65.5 0.0 2.3 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 AMD20666.1 - 2e-16 61.1 1.8 2e-16 61.1 1.8 6.7 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.6 AMD20666.1 - 3e-10 40.4 7.3 3.3e-05 23.9 0.2 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AMD20666.1 - 5.2e-05 22.9 0.1 0.00014 21.5 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain GAS PF13851.6 AMD20666.1 - 0.0035 16.7 15.0 0.0035 16.7 15.0 8.0 3 2 3 7 7 7 3 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 AMD20666.1 - 0.007 16.0 18.6 0.007 16.0 18.6 7.6 3 2 3 6 6 6 2 Ciliary protein causing Leber congenital amaurosis disease MscS_porin PF12795.7 AMD20666.1 - 0.0072 15.9 12.6 0.0072 15.9 12.6 5.7 3 2 3 6 6 6 3 Mechanosensitive ion channel porin domain Raco_middle PF17651.1 AMD20666.1 - 6.6 6.4 8.3 0.64 9.7 0.1 3.1 3 0 0 3 3 3 0 RACo middle region FAD_binding_1 PF00667.20 AMD20667.1 - 1.7e-64 217.4 0.0 3e-64 216.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 AMD20667.1 - 5e-09 36.8 0.0 1.5e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR PF01558.18 AMD20667.1 - 0.0027 17.8 0.0 0.015 15.4 0.0 2.2 2 0 0 2 2 2 1 Pyruvate ferredoxin/flavodoxin oxidoreductase FAD_binding_6 PF00970.24 AMD20667.1 - 0.087 13.2 0.0 2.7 8.4 0.0 2.5 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain NUC PF18510.1 AMD20667.1 - 0.72 10.3 4.2 0.37 11.2 0.1 2.6 3 1 0 3 3 3 0 Nuclease domain RTP1_C1 PF10363.9 AMD20668.1 - 0.055 13.6 1.8 0.15 12.3 0.3 2.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 BAG PF02179.16 AMD20669.1 - 2e-14 53.8 1.4 3.7e-14 52.9 1.1 1.6 2 0 0 2 2 2 1 BAG domain DUF4891 PF16232.5 AMD20669.1 - 0.012 16.1 0.3 0.3 11.6 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4891) DUF4279 PF14106.6 AMD20669.1 - 0.048 13.9 0.1 0.091 13.0 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4279) Asp PF00026.23 AMD20670.1 - 1.6e-64 218.3 0.0 1.9e-64 218.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD20670.1 - 6e-09 36.4 0.5 3.8e-07 30.5 0.0 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 AMD20670.1 - 0.0087 16.6 0.7 5.3 7.7 0.1 4.1 3 1 0 3 3 3 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AMD20670.1 - 0.012 16.2 0.5 0.78 10.4 0.2 3.3 2 1 0 2 2 2 0 Aspartyl protease Lum_binding PF00677.17 AMD20671.1 - 1.6e-44 149.8 2.9 1.7e-21 76.0 0.9 2.2 2 0 0 2 2 2 2 Lumazine binding domain AgrD PF05931.11 AMD20671.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 Staphylococcal AgrD protein ANAPC4_WD40 PF12894.7 AMD20672.1 - 6.4e-08 32.8 3.7 0.0013 19.0 0.1 4.5 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Sortase PF04203.13 AMD20672.1 - 0.003 17.3 0.1 0.0065 16.3 0.1 1.5 1 0 0 1 1 1 1 Sortase domain WD40 PF00400.32 AMD20672.1 - 0.0075 17.1 10.4 0.28 12.1 0.5 5.6 6 1 0 6 6 6 1 WD domain, G-beta repeat HPS3_N PF14761.6 AMD20672.1 - 0.15 11.6 0.0 0.94 9.0 0.0 2.2 2 1 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Cut8 PF08559.10 AMD20673.1 - 3.5e-60 203.6 0.3 4.1e-60 203.4 0.3 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein DUF929 PF06053.11 AMD20674.1 - 0.096 12.0 0.0 0.11 11.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF929) SPATA24 PF15175.6 AMD20675.1 - 0.063 13.2 1.1 0.12 12.2 1.1 1.5 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 Nrf1_DNA-bind PF10491.9 AMD20675.1 - 0.091 12.5 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Sedlin_N PF04628.13 AMD20676.1 - 2.6e-48 163.4 0.0 3.2e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 AMD20676.1 - 9.8e-06 25.5 0.1 1.3e-05 25.2 0.1 1.6 1 1 0 1 1 1 1 Sybindin-like family MIS13 PF08202.11 AMD20677.1 - 4e-70 236.5 3.3 7.5e-70 235.6 3.3 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family Med22 PF06179.12 AMD20678.1 - 5.6e-19 68.3 2.4 6.4e-19 68.1 2.4 1.0 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Polysacc_deac_1 PF01522.21 AMD20678.1 - 0.12 12.3 0.8 0.42 10.5 0.3 1.8 1 1 0 2 2 2 0 Polysaccharide deacetylase DUF4611 PF15387.6 AMD20678.1 - 0.17 12.2 2.4 0.17 12.1 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) dUTPase PF00692.19 AMD20679.1 - 4.5e-46 155.7 0.0 5.3e-46 155.5 0.0 1.1 1 0 0 1 1 1 1 dUTPase Ntox30 PF15532.6 AMD20679.1 - 0.15 12.5 0.0 0.47 10.9 0.0 1.9 2 0 0 2 2 2 0 Bacterial toxin 30 Peptidase_M16 PF00675.20 AMD20680.1 - 2.6e-30 105.4 0.1 6.3e-30 104.1 0.1 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 AMD20680.1 - 8.6e-22 77.7 0.1 2.2e-21 76.4 0.1 1.8 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 AMD20680.1 - 1.2e-07 31.9 0.1 0.00046 20.3 0.0 3.5 4 1 0 4 4 4 2 Peptidase M16 inactive domain CID_GANP PF16766.5 AMD20680.1 - 0.057 13.6 0.7 0.34 11.2 0.0 2.5 2 0 0 2 2 2 0 Binding region of GANP to ENY2 Rrp15p PF07890.12 AMD20681.1 - 2.3e-32 112.1 12.9 2.3e-32 112.1 12.9 2.7 2 1 0 2 2 2 1 Rrp15p Caldesmon PF02029.15 AMD20681.1 - 0.18 10.6 43.3 0.23 10.2 43.3 1.0 1 0 0 1 1 1 0 Caldesmon Kinesin PF00225.23 AMD20682.1 - 7.8e-101 337.3 2.2 7.8e-101 337.3 2.2 2.9 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 AMD20682.1 - 8.6e-54 181.5 0.0 8.6e-54 181.5 0.0 2.6 3 0 0 3 3 3 1 Microtubule binding PhoH PF02562.16 AMD20682.1 - 0.023 14.1 2.8 4.4 6.7 0.0 3.4 3 0 0 3 3 3 0 PhoH-like protein Ribonucleas_3_2 PF11469.8 AMD20682.1 - 0.079 13.4 0.1 0.3 11.5 0.1 2.0 1 0 0 1 1 1 0 Ribonuclease III Acyltransferase PF01553.21 AMD20683.1 - 1.2e-14 54.1 0.0 2.1e-14 53.3 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 AMD20684.1 - 0.0031 17.1 0.0 0.012 15.3 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase DUF5355 PF17306.2 AMD20685.1 - 7.2e-54 183.0 0.0 5.3e-53 180.2 0.0 1.9 1 1 0 1 1 1 1 Family of unknown function (DUF5355) Ammonium_transp PF00909.21 AMD20686.1 - 7.9e-115 383.7 19.7 9.1e-115 383.5 19.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family VanZ PF04892.12 AMD20686.1 - 0.092 13.4 0.5 0.092 13.4 0.5 2.3 1 1 1 2 2 2 0 VanZ like family YuiB PF14068.6 AMD20686.1 - 1.6 9.3 5.6 0.61 10.7 1.0 2.7 2 1 1 3 3 3 0 Putative membrane protein Metallophos PF00149.28 AMD20687.1 - 1.7e-32 113.6 0.3 2.5e-32 113.1 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 AMD20687.1 - 9.5e-16 57.9 0.2 2.6e-15 56.5 0.0 1.8 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 AMD20687.1 - 7.6e-13 47.7 0.4 0.00035 20.2 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD20687.1 - 7.9e-12 44.3 0.8 0.005 16.9 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 AMD20687.1 - 3.3e-09 36.3 0.1 0.0008 19.1 0.1 2.6 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 AMD20687.1 - 3.3e-07 30.2 0.0 0.0082 16.5 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 AMD20687.1 - 0.00014 21.8 0.7 5 7.6 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 AMD20687.1 - 0.0013 18.9 2.5 0.0061 16.7 0.2 3.0 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 AMD20687.1 - 0.0026 18.4 2.9 0.011 16.4 0.2 2.5 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 AMD20687.1 - 0.037 14.3 0.6 0.67 10.3 0.1 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20687.1 - 0.18 12.3 2.1 0.97 10.0 0.2 2.4 1 1 2 3 3 3 0 Tetratricopeptide repeat PH PF00169.29 AMD20688.1 - 0.0011 19.4 0.0 0.0031 18.0 0.0 1.8 1 0 0 1 1 1 1 PH domain Flavin_Reduct PF01613.18 AMD20689.1 - 7.2e-23 81.3 0.0 3.2e-22 79.2 0.0 1.8 1 1 0 1 1 1 1 Flavin reductase like domain RRG8 PF17068.5 AMD20690.1 - 1.2e-68 231.6 3.1 1.3e-68 231.4 3.1 1.0 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial Peptidase_C50 PF03568.17 AMD20691.1 - 1.2e-123 413.2 0.3 6e-123 410.9 0.0 2.2 2 0 0 2 2 2 1 Peptidase family C50 Telomere_reg-2 PF10193.9 AMD20692.1 - 1e-21 77.4 0.5 3.3e-21 75.8 0.5 2.0 1 0 0 1 1 1 1 Telomere length regulation protein RcsC PF09456.10 AMD20692.1 - 0.036 14.1 0.0 0.099 12.6 0.0 1.7 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) RTTN_N PF14726.6 AMD20692.1 - 0.043 14.6 1.0 0.26 12.1 0.1 2.8 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning RabGAP-TBC PF00566.18 AMD20693.1 - 8e-51 172.7 0.4 2.5e-50 171.1 0.4 1.9 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 AMD20693.1 - 1.9e-16 59.9 1.9 3.1e-16 59.3 0.5 2.2 2 0 0 2 2 2 1 GRAM domain EF-hand_6 PF13405.6 AMD20693.1 - 2.8e-05 23.7 0.6 0.089 12.8 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 AMD20693.1 - 0.0052 17.2 1.1 0.051 14.0 1.1 2.8 2 1 0 2 2 2 1 EF-hand domain pair Vps36_ESCRT-II PF11605.8 AMD20693.1 - 0.014 15.6 0.3 0.059 13.6 0.0 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 PH_TFIIH PF08567.11 AMD20693.1 - 0.016 15.5 0.0 0.079 13.3 0.0 2.2 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain EF-hand_1 PF00036.32 AMD20693.1 - 0.38 10.4 6.4 0.44 10.2 0.1 3.3 3 0 0 3 3 3 0 EF hand Rhomboid PF01694.22 AMD20694.1 - 1.2e-30 106.5 19.1 2.2e-30 105.6 19.1 1.4 1 0 0 1 1 1 1 Rhomboid family SCAI PF12070.8 AMD20694.1 - 0.056 12.3 0.5 0.77 8.6 0.2 2.0 2 0 0 2 2 2 0 Protein SCAI Gly-zipper_Omp PF13488.6 AMD20694.1 - 2.5 8.2 4.4 0.41 10.7 0.4 1.8 2 0 0 2 2 2 0 Glycine zipper Glu-tRNAGln PF02686.15 AMD20695.1 - 0.0096 16.2 0.3 0.027 14.8 0.3 2.0 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Pescadillo_N PF06732.11 AMD20696.1 - 3.1e-118 394.3 1.8 3.1e-118 394.3 1.8 2.2 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 AMD20696.1 - 1.6e-09 38.0 0.0 4.2e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain CDC45 PF02724.14 AMD20696.1 - 0.0024 16.3 11.6 0.0024 16.3 11.6 2.2 2 0 0 2 2 2 1 CDC45-like protein Med18 PF09637.10 AMD20697.1 - 1.1e-60 205.6 0.0 1.2e-60 205.4 0.0 1.0 1 0 0 1 1 1 1 Med18 protein VMA21 PF09446.10 AMD20698.1 - 5.2e-12 45.7 15.1 3.3e-11 43.1 15.1 1.9 1 1 0 1 1 1 1 VMA21-like domain ATP-synt_S1 PF05827.12 AMD20699.1 - 0.0052 16.6 0.0 0.0099 15.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) CT_C_D PF02682.16 AMD20699.1 - 0.055 13.2 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D IF-2B PF01008.17 AMD20700.1 - 3.7e-76 256.0 0.0 4.4e-76 255.8 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Cyclin_N PF00134.23 AMD20701.1 - 6.6e-39 132.6 0.2 2.3e-38 130.8 0.1 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AMD20701.1 - 1.2e-32 112.5 1.4 4.8e-32 110.5 0.0 2.4 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 AMD20702.1 - 1.1e-39 135.1 0.7 1.1e-39 135.1 0.7 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AMD20702.1 - 9.4e-16 58.0 0.2 2.9e-15 56.4 0.2 1.8 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF4769 PF15992.5 AMD20703.1 - 0.036 13.9 0.6 0.064 13.0 0.3 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4769) DUF2057 PF09829.9 AMD20703.1 - 3.7 7.7 13.6 0.1 12.7 7.4 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) WD40 PF00400.32 AMD20704.1 - 2.6e-15 56.5 0.5 7.5e-05 23.4 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat WD40_like PF17005.5 AMD20704.1 - 0.021 14.2 0.0 0.53 9.6 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain ANAPC4_WD40 PF12894.7 AMD20704.1 - 0.054 13.8 0.0 1.1 9.7 0.0 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Mcl1_mid PF12341.8 AMD20705.1 - 1.5e-83 280.6 0.0 1.4e-82 277.4 0.0 2.2 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 AMD20705.1 - 0.00013 22.2 0.0 0.0098 16.2 0.0 3.4 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AMD20705.1 - 0.0057 16.0 0.1 1.7 7.9 0.1 2.6 2 0 0 2 2 2 2 WD40-like domain PQQ_2 PF13360.6 AMD20705.1 - 0.019 14.5 0.0 1.1 8.8 0.0 2.7 2 1 1 3 3 3 0 PQQ-like domain COG2 PF06148.11 AMD20706.1 - 3.8e-06 27.0 9.0 6.9e-06 26.2 8.1 1.9 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Spectrin PF00435.21 AMD20706.1 - 2.4e-05 24.8 3.8 7.6e-05 23.2 1.6 2.4 1 1 1 2 2 2 1 Spectrin repeat Phage_min_cap2 PF06152.11 AMD20706.1 - 0.005 15.8 0.4 0.0083 15.1 0.4 1.3 1 0 0 1 1 1 1 Phage minor capsid protein 2 P22_AR_C PF10548.9 AMD20706.1 - 0.039 14.1 0.5 0.75 10.0 0.0 3.0 3 1 0 3 3 3 0 P22AR C-terminal domain FadA PF09403.10 AMD20706.1 - 0.058 13.9 1.5 0.65 10.5 0.0 2.5 2 1 0 2 2 2 0 Adhesion protein FadA Casc1_N PF15927.5 AMD20706.1 - 0.061 13.0 5.9 0.026 14.2 1.7 2.1 1 1 1 2 2 2 0 Cancer susceptibility candidate 1 N-terminus PhaP_Bmeg PF09602.10 AMD20706.1 - 0.15 12.0 9.7 0.38 10.7 4.1 3.0 1 1 1 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Plasmid_RAQPRD PF09686.10 AMD20706.1 - 0.24 11.6 2.1 0.56 10.4 0.2 2.5 3 1 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Nup54 PF13874.6 AMD20707.1 - 5.2e-35 120.6 3.0 5.2e-35 120.6 3.0 3.1 3 1 0 3 3 3 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 AMD20707.1 - 3.7e-20 72.6 148.5 2.1e-10 41.3 33.4 5.5 1 1 4 5 5 5 4 Nucleoporin FG repeat region TFIIA PF03153.13 AMD20707.1 - 8.6 6.2 35.9 7.2 6.5 34.0 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tom5 PF10642.9 AMD20708.1 - 2.1e-18 66.1 0.1 2.3e-18 65.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Med26 PF08711.11 AMD20709.1 - 4e-12 46.0 1.7 2e-11 43.7 0.1 2.6 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Ribosom_S12_S23 PF00164.25 AMD20710.1 - 1.2e-51 173.1 0.4 1.5e-51 172.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 LisH PF08513.11 AMD20711.1 - 0.014 15.4 0.0 0.03 14.3 0.0 1.6 1 0 0 1 1 1 0 LisH LisH_2 PF16045.5 AMD20711.1 - 0.1 11.6 0.1 0.6 9.2 0.1 2.3 3 0 0 3 3 3 0 LisH Acetyltransf_1 PF00583.25 AMD20713.1 - 4e-10 39.9 0.0 5.2e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 AMD20713.1 - 8.1e-06 25.7 0.0 1.3e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 AMD20713.1 - 1.8e-05 24.7 0.0 2.5e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AMD20713.1 - 5.7e-05 23.5 0.0 8.3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AMD20713.1 - 0.00063 19.9 0.0 0.00087 19.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain JAB PF01398.21 AMD20713.1 - 0.0016 18.4 0.0 0.0034 17.3 0.0 1.5 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF1196 PF06709.11 AMD20713.1 - 0.13 12.5 0.0 0.35 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1196) LSM14 PF12701.7 AMD20714.1 - 1.2e-25 89.4 0.0 2.4e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 AMD20714.1 - 4.8e-05 24.2 12.1 4.8e-05 24.2 12.1 3.3 1 1 1 2 2 2 1 FDF domain SM-ATX PF14438.6 AMD20714.1 - 7.2e-05 22.8 0.0 0.00024 21.2 0.0 1.9 1 0 0 1 1 1 1 Ataxin 2 SM domain TFIIA PF03153.13 AMD20714.1 - 0.00022 21.4 29.9 0.00027 21.0 29.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 AMD20714.1 - 0.019 13.7 34.8 0.028 13.1 34.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal LSM PF01423.22 AMD20714.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 LSM domain PepSY_TM PF03929.16 AMD20714.1 - 1.6 8.3 4.7 2 8.0 4.7 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Spem1 PF15670.5 AMD20714.1 - 3.7 7.1 21.8 0.7 9.4 18.3 1.6 2 0 0 2 2 2 0 Spermatid maturation protein 1 Connexin PF00029.19 AMD20714.1 - 9.3 5.9 10.5 18 5.0 10.5 1.6 1 0 0 1 1 1 0 Connexin Mito_carr PF00153.27 AMD20715.1 - 1.7e-53 178.5 2.3 8.8e-17 60.8 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 AMD20716.1 - 1.1e-70 233.4 5.7 2.5e-16 59.2 0.1 6.3 5 1 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AMD20716.1 - 2.7e-07 30.3 0.0 0.034 14.0 0.0 4.2 5 0 0 5 5 5 2 Occluded RNA-recognition motif RRM_5 PF13893.6 AMD20716.1 - 2.2e-05 24.1 0.0 0.00053 19.6 0.1 2.9 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AMD20716.1 - 0.0011 18.9 0.0 3.6 7.7 0.0 4.6 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif CwfJ_C_1 PF04677.15 AMD20717.1 - 6.1e-33 113.3 1.5 1.2e-32 112.4 1.5 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 AMD20717.1 - 5.3e-15 56.1 0.4 1.3e-14 54.9 0.2 1.7 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Pkinase PF00069.25 AMD20718.1 - 1e-55 189.0 0.0 5.9e-55 186.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20718.1 - 2.1e-28 99.3 0.2 5.2e-19 68.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD20718.1 - 3.5e-05 22.9 0.4 6.7e-05 22.0 0.4 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AMD20718.1 - 0.0012 18.3 0.0 0.0097 15.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 AMD20718.1 - 0.0037 17.9 0.5 0.0099 16.6 0.5 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.14 AMD20718.1 - 0.0069 15.8 0.3 0.046 13.1 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD20718.1 - 0.051 13.5 0.1 0.16 11.9 0.1 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family Nop PF01798.18 AMD20719.1 - 1.5e-52 178.3 0.2 2.3e-52 177.8 0.2 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 AMD20719.1 - 3.5e-22 79.6 1.8 6.7e-22 78.7 1.8 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain RNA_pol_A_bac PF01000.26 AMD20720.1 - 4.7e-29 101.0 0.0 1.1e-28 99.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AMD20720.1 - 5.4e-21 73.8 0.0 7.3e-21 73.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Prot_ATP_OB_N PF17758.1 AMD20720.1 - 0.22 11.2 0.1 0.41 10.3 0.1 1.4 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain DUF1746 PF08508.10 AMD20721.1 - 2.2e-07 31.2 0.1 4.7e-06 26.9 0.1 2.5 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1746) Nrap_D5 PF17406.2 AMD20722.1 - 1.5e-51 174.4 0.0 3.1e-51 173.4 0.0 1.6 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D4 PF17405.2 AMD20722.1 - 3.9e-49 166.9 0.1 6.4e-49 166.2 0.1 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D2 PF17403.2 AMD20722.1 - 1.9e-47 160.8 1.2 3e-46 157.0 0.4 2.4 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap PF03813.14 AMD20722.1 - 3.2e-45 153.9 1.4 8.8e-45 152.5 1.4 1.8 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 AMD20722.1 - 2.9e-39 134.7 0.0 6.1e-39 133.7 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 AMD20722.1 - 6.3e-28 97.7 0.2 1.4e-27 96.5 0.2 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 IFP_35_N PF07334.13 AMD20722.1 - 0.09 12.9 0.1 0.27 11.3 0.1 1.8 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Glyco_hydro_72 PF03198.14 AMD20723.1 - 1.2e-142 474.8 6.9 1.5e-142 474.5 6.9 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 AMD20723.1 - 0.0089 15.5 0.1 0.028 13.9 0.1 1.7 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) bZIP_1 PF00170.21 AMD20724.1 - 6e-05 23.1 12.3 7.8e-05 22.7 11.0 1.9 1 1 1 2 2 2 1 bZIP transcription factor Hap4_Hap_bind PF10297.9 AMD20724.1 - 0.00011 22.2 7.0 0.00018 21.5 7.0 1.3 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_Maf PF03131.17 AMD20724.1 - 0.0027 18.2 4.7 0.0061 17.1 4.7 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 AMD20724.1 - 0.052 13.6 19.2 0.092 12.8 13.9 2.5 1 1 1 2 2 2 0 Basic region leucine zipper RNase_HII PF01351.18 AMD20724.1 - 0.17 11.7 1.7 0.24 11.2 1.7 1.2 1 0 0 1 1 1 0 Ribonuclease HII HAUS6_N PF14661.6 AMD20724.1 - 0.23 11.0 3.4 0.28 10.7 3.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus KIAA1430 PF13879.6 AMD20724.1 - 3.4 8.5 13.4 3.6 8.4 2.3 2.6 1 1 1 2 2 2 0 KIAA1430 homologue WSC PF01822.19 AMD20725.1 - 2e-11 43.9 12.7 5.5e-11 42.5 12.7 1.7 1 0 0 1 1 1 1 WSC domain MadL PF03817.13 AMD20725.1 - 0.0072 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Malonate transporter MadL subunit TMEM51 PF15345.6 AMD20725.1 - 0.0081 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 51 DUF5305 PF17231.2 AMD20725.1 - 0.018 14.5 0.1 0.026 14.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Herpes_gE PF02480.16 AMD20725.1 - 0.049 12.4 0.0 0.06 12.1 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E TMEM154 PF15102.6 AMD20725.1 - 0.06 13.3 1.1 0.1 12.5 0.2 1.8 1 1 1 2 2 2 0 TMEM154 protein family Podoplanin PF05808.11 AMD20725.1 - 0.19 11.8 4.8 0.47 10.6 4.8 1.6 1 1 0 1 1 1 0 Podoplanin VPDSG-CTERM PF18205.1 AMD20725.1 - 1.8 8.5 5.5 3.5 7.5 5.5 1.5 1 0 0 1 1 1 0 VPDSG-CTERM motif DUF2408 PF10303.9 AMD20726.1 - 1.6e-46 158.2 16.9 8.5e-33 113.8 0.5 4.9 2 2 2 4 4 4 3 Protein of unknown function (DUF2408) NPV_P10 PF05531.12 AMD20726.1 - 0.0019 18.7 5.6 1.5 9.3 0.6 4.3 2 1 2 4 4 4 2 Nucleopolyhedrovirus P10 protein NapD PF03927.13 AMD20726.1 - 0.02 14.9 0.3 0.12 12.5 0.1 2.3 2 0 0 2 2 2 0 NapD protein AATF-Che1 PF13339.6 AMD20726.1 - 0.55 10.9 10.1 0.15 12.8 1.2 3.8 2 2 1 3 3 3 0 Apoptosis antagonizing transcription factor UPF0449 PF15136.6 AMD20726.1 - 0.57 10.7 5.4 0.18 12.3 0.4 2.7 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 FAA_hydro_N_2 PF18288.1 AMD20726.1 - 0.68 10.4 2.7 66 4.0 0.0 3.9 4 0 0 4 4 4 0 Fumarylacetoacetase N-terminal domain 2 DUF2205 PF10224.9 AMD20726.1 - 3.9 7.5 6.0 1.3 9.1 2.1 2.3 2 0 0 2 2 2 0 Short coiled-coil protein AhpC-TSA PF00578.21 AMD20727.1 - 8.5e-26 90.3 0.0 1.3e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AMD20727.1 - 8.4e-16 58.0 0.0 1.4e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 AMD20727.1 - 0.024 14.8 0.0 0.038 14.1 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme DUF1644 PF07800.12 AMD20727.1 - 0.035 14.2 0.4 0.052 13.6 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) Rota_NS26 PF01525.16 AMD20727.1 - 0.041 13.9 3.1 3.7 7.5 0.5 2.4 2 0 0 2 2 2 0 Rotavirus NS26 cwf18 PF08315.12 AMD20727.1 - 0.45 11.2 5.5 0.8 10.4 5.5 1.4 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor Adap_comp_sub PF00928.21 AMD20728.1 - 1.1e-87 293.8 0.0 1.4e-87 293.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AMD20728.1 - 1.7e-05 24.7 0.6 3.2e-05 23.9 0.6 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HBB PF06777.11 AMD20728.1 - 0.061 13.0 0.1 0.096 12.4 0.1 1.2 1 0 0 1 1 1 0 Helical and beta-bridge domain TPP1 PF10341.9 AMD20729.1 - 4.5e-21 74.9 0.0 8.2e-21 74.1 0.0 1.4 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Urm1 PF09138.11 AMD20730.1 - 1.4e-35 121.5 0.7 1.5e-35 121.4 0.7 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 AMD20730.1 - 0.00022 21.8 0.0 0.00027 21.5 0.0 1.2 1 0 0 1 1 1 1 ThiS family DUF507 PF04368.13 AMD20730.1 - 0.046 13.7 0.2 0.055 13.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF507) SWIB PF02201.18 AMD20730.1 - 0.15 12.0 0.1 0.28 11.1 0.1 1.4 1 1 0 1 1 1 0 SWIB/MDM2 domain Nas2_N PF18265.1 AMD20731.1 - 6.3e-21 74.1 0.8 1.2e-20 73.2 0.8 1.5 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 AMD20731.1 - 3e-09 36.6 0.3 5.1e-09 35.8 0.3 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 AMD20731.1 - 3.5e-08 33.7 0.1 5.1e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 AMD20731.1 - 8.7e-06 26.0 0.0 1.8e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 AMD20731.1 - 3.7e-05 24.1 0.0 5.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Septin PF00735.18 AMD20731.1 - 0.053 12.8 0.1 0.092 12.0 0.0 1.4 2 0 0 2 2 2 0 Septin bZIP_2 PF07716.15 AMD20732.1 - 1.6e-12 47.3 7.8 1.6e-12 47.3 7.8 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 AMD20732.1 - 2.7e-10 40.2 8.9 5.1e-10 39.3 8.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 AMD20732.1 - 0.0018 18.8 3.0 0.0039 17.7 3.0 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor GIT_CC PF16559.5 AMD20732.1 - 0.02 14.7 1.1 0.046 13.6 1.1 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor HMMR_N PF15905.5 AMD20732.1 - 0.022 14.2 2.8 0.029 13.8 2.8 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal ZapB PF06005.12 AMD20732.1 - 0.15 12.5 5.6 0.1 13.1 3.6 1.7 2 0 0 2 2 2 0 Cell division protein ZapB HALZ PF02183.18 AMD20732.1 - 0.57 10.5 6.3 0.15 12.3 2.3 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper Gti1_Pac2 PF09729.9 AMD20733.1 - 1.5e-54 184.9 8.9 1.3e-53 181.8 0.3 3.4 2 1 0 2 2 2 1 Gti1/Pac2 family PAT1 PF09770.9 AMD20733.1 - 3.9 5.6 15.2 4.7 5.4 15.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Mito_carr PF00153.27 AMD20734.1 - 6.8e-72 237.5 5.5 2e-24 85.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Thioredoxin PF00085.20 AMD20735.1 - 1.1e-24 86.3 0.3 1.3e-20 73.3 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 AMD20735.1 - 5e-05 23.3 5.4 0.0013 18.7 0.5 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_4 PF13462.6 AMD20735.1 - 0.021 15.0 0.1 0.052 13.7 0.1 1.7 1 0 0 1 1 1 0 Thioredoxin Use1 PF09753.9 AMD20736.1 - 8.9e-05 22.3 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Sec20 PF03908.13 AMD20736.1 - 0.0022 17.9 2.7 0.016 15.1 0.3 2.1 1 1 1 2 2 2 2 Sec20 Synaptobrevin PF00957.21 AMD20736.1 - 0.018 14.8 3.7 0.031 14.0 3.7 1.4 1 1 0 1 1 1 0 Synaptobrevin MttA_Hcf106 PF02416.16 AMD20736.1 - 4.8 6.6 5.9 0.89 8.9 1.4 2.1 3 0 0 3 3 3 0 mttA/Hcf106 family ParA PF10609.9 AMD20737.1 - 9e-94 313.5 0.0 1e-93 313.3 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 AMD20737.1 - 2.9e-09 37.1 0.0 1.1e-08 35.1 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 AMD20737.1 - 4.4e-06 26.2 0.0 1.3e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 AMD20737.1 - 8e-06 25.2 0.3 3.2e-05 23.3 0.2 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.6 AMD20737.1 - 1.3e-05 25.2 0.6 0.00011 22.1 0.6 2.2 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 AMD20737.1 - 0.0005 19.6 0.1 0.93 8.9 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 AMD20737.1 - 0.0012 18.4 0.0 0.0022 17.5 0.0 1.4 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 AMD20737.1 - 0.03 13.3 0.1 0.049 12.6 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_26 PF13500.6 AMD20737.1 - 0.086 12.6 0.3 0.45 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AMD20737.1 - 0.15 11.6 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain dCache_2 PF08269.11 AMD20738.1 - 0.017 14.3 3.2 0.027 13.7 3.2 1.2 1 0 0 1 1 1 0 Cache domain TMPIT PF07851.13 AMD20738.1 - 0.021 14.1 2.7 0.03 13.6 2.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein IP_trans PF02121.18 AMD20738.1 - 0.048 13.2 0.8 0.073 12.6 0.8 1.3 1 0 0 1 1 1 0 Phosphatidylinositol transfer protein NPV_P10 PF05531.12 AMD20738.1 - 0.11 13.0 3.8 2.5 8.6 3.8 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Tup_N PF08581.10 AMD20738.1 - 0.13 12.6 4.2 0.29 11.5 2.6 2.4 2 1 0 2 2 2 0 Tup N-terminal Baculo_PEP_C PF04513.12 AMD20738.1 - 0.2 11.7 6.1 0.33 11.0 6.1 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nup54 PF13874.6 AMD20738.1 - 0.32 11.1 6.1 0.13 12.4 3.0 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 LMBR1 PF04791.16 AMD20738.1 - 0.32 9.8 0.5 0.37 9.7 0.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein XhlA PF10779.9 AMD20738.1 - 0.34 11.2 3.9 0.72 10.1 3.9 1.6 1 0 0 1 1 1 0 Haemolysin XhlA Fzo_mitofusin PF04799.13 AMD20738.1 - 0.63 9.6 4.3 1 8.9 4.3 1.3 1 0 0 1 1 1 0 fzo-like conserved region ISG65-75 PF11727.8 AMD20738.1 - 0.89 8.7 5.2 1.2 8.4 5.2 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Prefoldin_2 PF01920.20 AMD20739.1 - 1.2e-21 76.6 5.0 1.3e-21 76.5 5.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF2383 PF09537.10 AMD20739.1 - 0.031 14.6 0.1 0.18 12.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) DDOST_48kD PF03345.14 AMD20740.1 - 2.2e-122 408.9 0.4 2.7e-122 408.6 0.4 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Tropomyosin_1 PF12718.7 AMD20741.1 - 0.0014 18.8 2.5 0.0016 18.6 2.5 1.1 1 0 0 1 1 1 1 Tropomyosin like DUF4349 PF14257.6 AMD20741.1 - 0.0018 17.7 1.0 0.0022 17.5 1.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) CotH PF08757.11 AMD20741.1 - 0.016 14.8 0.3 0.016 14.7 0.3 1.0 1 0 0 1 1 1 0 CotH kinase protein Apolipoprotein PF01442.18 AMD20741.1 - 0.02 14.8 0.3 0.022 14.7 0.3 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain YvrJ PF12841.7 AMD20741.1 - 0.041 13.4 0.3 0.068 12.7 0.3 1.3 1 0 0 1 1 1 0 YvrJ protein family UPF0449 PF15136.6 AMD20741.1 - 0.053 14.0 0.7 0.055 13.9 0.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Fzo_mitofusin PF04799.13 AMD20741.1 - 0.15 11.6 0.4 0.14 11.6 0.4 1.0 1 0 0 1 1 1 0 fzo-like conserved region Syja_N PF02383.18 AMD20742.1 - 1.9e-46 158.9 0.7 3.1e-46 158.2 0.7 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 AMD20742.1 - 5.2e-09 36.0 0.0 8e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3455 PF11937.8 AMD20742.1 - 0.093 13.1 0.1 1.5 9.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3455) Wzt_C PF14524.6 AMD20743.1 - 0.00043 20.3 0.6 0.00068 19.7 0.6 1.2 1 0 0 1 1 1 1 Wzt C-terminal domain KdpC PF02669.15 AMD20743.1 - 0.07 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Nop16 PF09420.10 AMD20744.1 - 3.1e-64 216.9 9.1 3.6e-64 216.7 9.1 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 PMI_typeI PF01238.21 AMD20745.1 - 1.1e-146 488.8 0.0 1.3e-146 488.6 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 AMD20745.1 - 6.1e-06 26.2 0.0 0.0043 16.9 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_2 PF07883.11 AMD20745.1 - 0.13 12.0 0.0 5.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Cupin domain Hexapep PF00132.24 AMD20746.1 - 0.00016 21.3 16.6 0.0046 16.6 3.1 5.1 4 1 1 5 5 5 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 AMD20746.1 - 0.76 8.6 5.3 0.27 10.1 1.8 1.7 1 1 1 2 2 2 0 L-fucokinase Hexapep_2 PF14602.6 AMD20746.1 - 5.1 6.9 15.1 15 5.5 9.1 3.7 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase GDA1_CD39 PF01150.17 AMD20747.1 - 8e-131 436.6 2.2 1.3e-130 435.9 2.2 1.2 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF2149 PF09919.9 AMD20747.1 - 0.064 13.5 0.4 0.2 11.9 0.4 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) TFIIB PF00382.19 AMD20748.1 - 2.1e-50 168.6 4.2 5e-26 90.5 1.3 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AMD20748.1 - 4.1e-13 48.6 0.8 7e-13 47.9 0.8 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.6 AMD20748.1 - 0.035 13.5 1.0 1.5 8.3 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Poxvirus PF06227.12 AMD20748.1 - 0.076 12.8 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 dsDNA Poxvirus GN3L_Grn1 PF08701.11 AMD20749.1 - 1.1e-22 79.9 17.7 1.1e-22 79.9 17.7 2.1 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 AMD20749.1 - 1.9e-20 73.1 0.1 3.1e-14 53.0 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD20749.1 - 4.2e-09 36.1 0.0 1e-07 31.6 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AMD20749.1 - 2.3e-06 27.6 0.1 6.3e-05 22.9 0.1 2.3 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 AMD20749.1 - 9.8e-05 22.5 6.8 0.091 12.8 0.0 3.7 2 2 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 AMD20749.1 - 0.00039 20.0 0.5 0.08 12.5 0.2 3.0 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 AMD20749.1 - 0.0061 16.2 0.0 0.97 9.0 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 AMD20749.1 - 0.01 16.4 0.5 0.075 13.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 AMD20749.1 - 0.027 14.7 0.0 5 7.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 AMD20749.1 - 0.029 13.4 0.0 0.029 13.4 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 AMD20749.1 - 0.11 12.8 0.8 4.3 7.7 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain LRR_4 PF12799.7 AMD20750.1 - 1.2e-15 57.4 38.7 2.2e-06 27.9 3.1 7.0 3 2 5 8 8 8 6 Leucine Rich repeats (2 copies) CAP_GLY PF01302.25 AMD20750.1 - 3.6e-14 52.5 0.2 6.5e-14 51.7 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_8 PF13855.6 AMD20750.1 - 2.8e-11 43.0 29.3 1.3e-06 28.1 6.4 6.1 2 1 5 7 7 7 5 Leucine rich repeat LRR_9 PF14580.6 AMD20750.1 - 2.3e-05 24.0 2.5 2.3e-05 24.0 2.5 2.5 1 1 1 2 2 2 1 Leucine-rich repeat LysM PF01476.20 AMD20750.1 - 0.00037 20.5 1.9 0.0018 18.3 0.0 3.3 3 0 0 3 3 3 1 LysM domain LRR_6 PF13516.6 AMD20750.1 - 0.0033 17.3 28.2 1.3 9.2 0.2 8.1 8 0 0 8 8 8 2 Leucine Rich repeat LRR_1 PF00560.33 AMD20750.1 - 2.2 9.1 27.2 4 8.4 0.4 8.0 6 2 0 6 6 6 0 Leucine Rich Repeat Pre-PUA PF17832.1 AMD20751.1 - 1.8e-25 89.4 2.0 2.9e-25 88.8 2.0 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 AMD20751.1 - 2.5e-21 75.4 0.1 4.9e-21 74.5 0.0 1.5 2 0 0 2 2 2 1 PUA domain DUF1947 PF09183.10 AMD20751.1 - 0.0019 18.4 0.2 0.0046 17.2 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1947) ResIII PF04851.15 AMD20752.1 - 2.5e-21 76.4 0.4 2.9e-20 73.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AMD20752.1 - 2.3e-19 69.8 0.4 1.5e-18 67.2 0.2 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD20752.1 - 2.3e-18 66.6 0.0 8.9e-18 64.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AMD20752.1 - 0.00051 20.3 0.0 0.034 14.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain SWI2_SNF2 PF18766.1 AMD20752.1 - 0.0017 18.1 0.0 0.0051 16.5 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase PhoH PF02562.16 AMD20752.1 - 0.016 14.7 0.0 0.036 13.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Sec3_C PF09763.9 AMD20753.1 - 1.6e-151 506.1 20.2 1.6e-151 506.1 20.2 1.9 2 0 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 AMD20753.1 - 1.3e-22 79.7 0.1 4.4e-22 78.0 0.1 2.0 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 AMD20753.1 - 7.7e-07 28.2 0.3 1.6e-06 27.2 0.3 1.4 1 0 0 1 1 1 1 Vps52 / Sac2 family BCNT PF07572.12 AMD20753.1 - 0.0066 16.5 1.7 5.6 7.1 0.1 3.9 4 0 0 4 4 4 2 Bucentaur or craniofacial development DUF745 PF05335.13 AMD20753.1 - 0.81 9.4 2.8 0.78 9.4 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) NTF2 PF02136.20 AMD20754.1 - 3.4e-35 121.2 0.5 3.8e-35 121.1 0.5 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 AMD20754.1 - 0.00065 19.0 0.2 0.0016 17.7 0.2 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) DUF4440 PF14534.6 AMD20754.1 - 0.081 13.3 0.0 0.097 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Aim21 PF11489.8 AMD20755.1 - 1.1e-13 51.1 41.8 3.9e-13 49.2 34.5 3.3 2 1 1 3 3 3 2 Altered inheritance of mitochondria protein 21 DnaJ-X PF14308.6 AMD20756.1 - 3.5e-73 245.5 1.1 3.5e-73 245.5 1.1 2.6 2 1 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 AMD20756.1 - 1e-23 83.2 1.5 3.3e-23 81.6 1.5 2.0 1 0 0 1 1 1 1 DnaJ domain CytochromB561_N PF09786.9 AMD20756.1 - 0.021 13.8 6.4 0.031 13.3 6.4 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal Ndc1_Nup PF09531.10 AMD20756.1 - 0.15 10.7 4.7 0.19 10.4 4.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDK2AP PF09806.9 AMD20756.1 - 0.18 11.8 6.4 0.31 11.1 6.4 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Hid1 PF12722.7 AMD20756.1 - 1.3 7.1 11.1 1.9 6.5 11.1 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 AMD20756.1 - 1.3 7.7 11.9 2.2 7.0 11.9 1.3 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 AMD20756.1 - 2.8 7.5 24.2 2.3 7.8 21.8 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Membralin PF09746.9 AMD20756.1 - 10 5.1 11.7 15 4.5 11.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein RraA-like PF03737.15 AMD20757.1 - 1.8e-30 106.1 0.0 2.2e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA RRM_1 PF00076.22 AMD20758.1 - 2.7e-15 55.9 0.0 4.2e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AraC_binding PF02311.19 AMD20758.1 - 0.13 12.2 0.9 0.69 9.8 0.1 2.0 2 0 0 2 2 2 0 AraC-like ligand binding domain EF-hand_4 PF12763.7 AMD20759.1 - 4.1e-26 90.9 0.0 6.4e-13 48.6 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.11 AMD20759.1 - 1.5e-10 41.3 132.3 1e-05 25.8 31.3 10.6 5 3 6 11 11 11 6 Domain of unknown function (DUF1720) EF-hand_6 PF13405.6 AMD20759.1 - 2.4e-08 33.3 0.1 0.064 13.2 0.0 4.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 AMD20759.1 - 8.6e-08 31.2 0.0 0.00098 18.5 0.0 3.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 AMD20759.1 - 6.5e-07 29.7 0.0 0.0027 18.1 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 AMD20759.1 - 0.082 12.8 0.0 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair E3_binding PF02817.17 AMD20759.1 - 0.11 12.8 0.0 0.34 11.3 0.0 1.8 1 0 0 1 1 1 0 e3 binding domain EF-hand_5 PF13202.6 AMD20759.1 - 0.15 11.6 0.0 0.4 10.3 0.0 1.7 1 0 0 1 1 1 0 EF hand SRP1_TIP1 PF00660.17 AMD20760.1 - 1.2e-24 86.2 0.0 1.8e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family ARD PF03079.14 AMD20761.1 - 8.3e-41 139.8 0.4 9.5e-41 139.6 0.4 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 AMD20761.1 - 5e-08 32.6 0.1 9.1e-08 31.7 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 AMD20761.1 - 0.0038 17.1 0.0 0.0064 16.4 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 AMD20761.1 - 0.039 13.5 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Cupin PQ-loop PF04193.14 AMD20762.1 - 7.2e-11 41.7 18.2 1e-09 38.0 3.7 4.1 3 1 1 4 4 4 3 PQ loop repeat COX2-transmemb PF09125.10 AMD20762.1 - 0.62 9.9 2.9 2.4 8.0 0.1 2.8 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane TauD PF02668.16 AMD20763.1 - 4e-43 148.1 0.0 5.8e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 AMD20763.1 - 0.00022 21.8 0.0 0.00053 20.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 AMD20763.1 - 0.091 11.9 0.0 0.26 10.4 0.0 1.7 2 0 0 2 2 2 0 CsiD TP6A_N PF04406.14 AMD20764.1 - 1.4e-14 53.8 0.2 3.2e-14 52.7 0.1 1.7 2 0 0 2 2 2 1 Type IIB DNA topoisomerase EMP24_GP25L PF01105.24 AMD20765.1 - 4.1e-36 124.6 0.0 4.8e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RPN7 PF10602.9 AMD20766.1 - 9.4e-55 185.0 4.4 1.9e-54 184.0 4.4 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 AMD20766.1 - 2.6e-16 60.0 1.0 9.2e-16 58.3 0.2 2.2 2 0 0 2 2 2 1 PCI domain TPR_12 PF13424.6 AMD20766.1 - 0.019 15.3 0.5 0.12 12.7 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 AMD20766.1 - 0.019 14.9 0.3 0.04 13.9 0.1 1.8 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family TPR_8 PF13181.6 AMD20766.1 - 0.021 15.0 0.1 0.12 12.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Interferon PF00143.19 AMD20766.1 - 0.026 14.7 0.5 0.061 13.5 0.5 1.6 1 0 0 1 1 1 0 Interferon alpha/beta domain TPR_7 PF13176.6 AMD20766.1 - 0.048 13.7 0.0 2.8 8.2 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1955 PF09205.10 AMD20766.1 - 0.091 12.5 0.2 0.24 11.1 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) Jnk-SapK_ap_N PF09744.9 AMD20767.1 - 0.19 12.0 19.6 0.036 14.3 4.2 2.3 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 AMD20767.1 - 0.37 10.8 10.1 0.55 10.3 3.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 AMD20767.1 - 1.4 8.9 12.6 1.2 9.1 6.1 3.0 1 1 1 3 3 3 0 Laminin Domain II DUF4164 PF13747.6 AMD20767.1 - 2.7 8.4 13.9 20 5.5 0.8 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF948 PF06103.11 AMD20767.1 - 3.4 8.0 12.7 2.2 8.6 2.5 3.6 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Cluap1 PF10234.9 AMD20767.1 - 4.5 6.6 20.8 0.16 11.4 10.2 2.5 2 1 1 3 3 3 0 Clusterin-associated protein-1 Fzo_mitofusin PF04799.13 AMD20767.1 - 5.1 6.6 16.5 14 5.2 2.5 3.5 3 0 0 3 3 3 0 fzo-like conserved region DivIC PF04977.15 AMD20767.1 - 6.7 6.6 18.6 12 5.8 0.4 4.8 4 1 1 5 5 5 0 Septum formation initiator ATG16 PF08614.11 AMD20767.1 - 6.9 6.8 22.9 3.2 7.9 6.5 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) cwf21 PF08312.12 AMD20769.1 - 2.5e-13 49.9 5.3 4.4e-13 49.1 5.3 1.4 1 0 0 1 1 1 1 cwf21 domain Trans_reg_C PF00486.28 AMD20769.1 - 0.0032 17.5 1.4 0.15 12.1 0.9 2.5 1 1 1 2 2 2 2 Transcriptional regulatory protein, C terminal OrfB_Zn_ribbon PF07282.11 AMD20770.1 - 5.8e-16 58.2 1.7 1.2e-15 57.2 1.7 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain HTH_OrfB_IS605 PF12323.8 AMD20770.1 - 2.1e-07 30.3 0.2 5.6e-07 28.9 0.2 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain OrfB_IS605 PF01385.19 AMD20770.1 - 1.8e-05 24.9 1.9 2.8e-05 24.3 0.4 2.1 2 0 0 2 2 2 1 Probable transposase ODC_AZ PF02100.17 AMD20771.1 - 0.0022 17.9 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme MIP PF00230.20 AMD20772.1 - 1.2e-40 139.6 21.6 1.9e-40 139.0 21.6 1.3 1 0 0 1 1 1 1 Major intrinsic protein PhoLip_ATPase_C PF16212.5 AMD20772.1 - 1.2 8.8 6.3 0.11 12.2 1.0 1.8 1 1 1 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal Glyco_transf_15 PF01793.16 AMD20773.1 - 8.3e-134 445.9 12.9 1e-133 445.6 12.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TPR_2 PF07719.17 AMD20774.1 - 2.2e-13 49.2 1.9 0.0036 17.3 0.0 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 AMD20774.1 - 1.6e-12 46.7 5.0 0.00018 21.2 0.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD20774.1 - 9.2e-07 29.0 1.4 2.1e-06 27.9 0.5 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 AMD20774.1 - 5.6e-06 26.0 0.8 0.42 10.3 0.0 3.5 2 1 1 3 3 3 3 TPR repeat TPR_8 PF13181.6 AMD20774.1 - 6.6e-06 25.9 7.0 0.066 13.5 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20774.1 - 1.8e-05 25.2 0.7 0.0075 16.8 0.1 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 AMD20774.1 - 0.00013 22.0 2.4 0.13 12.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD20774.1 - 0.00018 21.8 0.1 1.2 9.5 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 AMD20774.1 - 0.00038 21.0 0.0 0.11 13.2 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat DUF3808 PF10300.9 AMD20774.1 - 0.00088 18.1 1.2 0.0012 17.7 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_14 PF13428.6 AMD20774.1 - 0.00098 19.8 0.1 1.4 9.9 0.0 4.4 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 AMD20774.1 - 0.0035 17.9 0.7 2.6 8.9 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AMD20774.1 - 0.14 12.2 4.3 11 6.1 0.1 3.4 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat INCENP_ARK-bind PF03941.15 AMD20775.1 - 5.6e-16 58.2 0.2 5.6e-16 58.2 0.2 2.3 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region zf_CCCH_4 PF18345.1 AMD20777.1 - 1.6e-11 43.9 17.5 6.3e-06 26.1 3.2 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 AMD20777.1 - 5.2e-10 39.0 11.9 9.6e-05 22.2 2.3 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 AMD20777.1 - 6.1e-09 36.6 8.5 0.00023 21.8 2.6 2.3 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 AMD20777.1 - 2.4e-08 33.6 12.3 0.00014 21.6 4.1 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 AMD20777.1 - 0.00026 21.2 2.6 0.00075 19.7 2.7 1.7 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 AMD20777.1 - 0.0033 17.8 14.2 0.26 11.8 4.2 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger LRR_6 PF13516.6 AMD20778.1 - 3.6e-05 23.5 3.7 0.15 12.2 0.0 3.9 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 AMD20778.1 - 0.0033 17.8 4.3 1.1 9.7 0.0 3.4 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) Lge1 PF11488.8 AMD20779.1 - 3.2e-18 65.6 2.4 3.2e-18 65.6 2.4 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein LGE1 Menin PF05053.13 AMD20779.1 - 0.91 7.8 5.5 1.2 7.4 5.5 1.1 1 0 0 1 1 1 0 Menin adh_short PF00106.25 AMD20780.1 - 9.3e-37 126.4 0.0 1.3e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AMD20780.1 - 1.7e-21 76.9 0.0 2.2e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD20780.1 - 2.5e-08 34.0 0.0 8.9e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 AMD20780.1 - 0.061 12.4 0.0 0.086 12.0 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Dus PF01207.17 AMD20780.1 - 0.15 11.1 0.0 9.7 5.2 0.0 2.2 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Pkinase PF00069.25 AMD20781.1 - 1e-73 248.0 0.0 1.2e-73 247.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20781.1 - 4.1e-34 118.0 0.0 5.2e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20781.1 - 6.2e-06 25.7 0.0 1.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AMD20781.1 - 0.00062 18.8 0.1 0.004 16.1 0.1 2.0 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AMD20781.1 - 0.0036 17.3 0.3 0.062 13.2 0.1 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 AMD20781.1 - 0.013 14.9 0.4 0.049 13.0 0.1 2.0 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 AMD20781.1 - 0.081 12.0 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF2401 PF10287.9 AMD20782.1 - 4.8e-88 294.6 0.5 7.3e-88 294.0 0.5 1.3 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 AMD20782.1 - 8.3e-25 87.0 0.1 1.7e-24 86.0 0.1 1.6 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) RR_TM4-6 PF06459.12 AMD20782.1 - 1.8 8.3 5.7 3.2 7.5 5.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RAMP4 PF06624.12 AMD20783.1 - 3.3e-13 49.5 0.0 3.7e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Exo5 PF09810.9 AMD20784.1 - 4e-49 168.0 0.0 5.3e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 AMD20784.1 - 0.002 18.1 0.2 0.33 10.8 0.0 3.0 3 0 0 3 3 3 1 PD-(D/E)XK nuclease superfamily DUF3164 PF11363.8 AMD20784.1 - 0.056 13.0 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) Glutaredoxin PF00462.24 AMD20785.1 - 6.4e-17 61.5 0.0 1e-16 60.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin AMP-binding PF00501.28 AMD20786.1 - 3.6e-81 272.9 0.0 4.6e-81 272.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FTR1 PF03239.14 AMD20787.1 - 2.4e-94 316.0 9.1 2.9e-94 315.7 9.1 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family DUF3149 PF11346.8 AMD20787.1 - 0.11 12.1 0.4 0.11 12.1 0.4 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3149) S_2TMBeta PF18153.1 AMD20787.1 - 1.5 8.6 4.2 0.51 10.1 0.6 2.1 2 0 0 2 2 2 0 SMODS-associating 2TM, beta-strand rich effector domain Tmemb_14 PF03647.13 AMD20787.1 - 5.9 7.7 13.3 0.87 10.4 1.4 2.9 3 0 0 3 3 3 0 Transmembrane proteins 14C DUF3180 PF11377.8 AMD20787.1 - 9.8 6.3 8.7 1.4 9.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) CorA PF01544.18 AMD20788.1 - 0.0045 16.3 7.6 0.012 15.0 7.4 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Glyco_transf_15 PF01793.16 AMD20789.1 - 4.8e-125 417.1 11.0 6.1e-125 416.8 11.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Abhydrolase_1 PF00561.20 AMD20790.1 - 1.6e-10 41.1 0.2 1.1e-09 38.3 0.0 2.6 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AMD20790.1 - 9.3e-10 39.5 0.0 1.3e-09 39.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD20790.1 - 2.6e-09 36.7 0.0 5.1e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 AMD20790.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase NIF PF03031.18 AMD20791.1 - 2.3e-40 137.9 0.0 4e-40 137.1 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PigN PF04987.14 AMD20791.1 - 0.27 10.0 0.0 0.4 9.5 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Pro_isomerase PF00160.21 AMD20792.1 - 2.6e-07 31.0 0.0 1.2e-05 25.7 0.0 2.3 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SspH PF08141.12 AMD20792.1 - 0.12 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Small acid-soluble spore protein H family VPS28 PF03997.12 AMD20793.1 - 1.1e-72 243.7 5.3 1.3e-72 243.5 5.3 1.0 1 0 0 1 1 1 1 VPS28 protein EntA_Immun PF08951.10 AMD20793.1 - 0.023 15.0 1.0 0.023 15.0 1.0 2.3 3 0 0 3 3 3 0 Enterocin A Immunity Spectrin_like PF18373.1 AMD20793.1 - 0.03 14.4 0.6 5.3 7.2 0.1 2.6 2 0 0 2 2 2 0 Spectrin like domain Phage_TAC_3 PF06896.11 AMD20793.1 - 0.041 14.5 1.8 0.27 11.8 0.2 2.5 1 1 1 2 2 2 0 Phage tail assembly chaperone proteins, TAC DUF1759 PF03564.15 AMD20793.1 - 0.048 13.6 1.6 6.8 6.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) Thioredoxin_8 PF13905.6 AMD20793.1 - 0.095 13.0 0.2 2.8 8.3 0.2 2.5 1 1 0 1 1 1 0 Thioredoxin-like Arrestin_C PF02752.22 AMD20794.1 - 0.0012 19.3 6.0 0.042 14.3 0.4 2.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain MCM PF00493.23 AMD20795.1 - 2e-104 347.6 0.0 5.5e-104 346.2 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 AMD20795.1 - 2.6e-33 114.5 1.2 4.7e-33 113.7 1.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AMD20795.1 - 7.4e-23 80.8 0.8 2e-22 79.4 0.8 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AMD20795.1 - 3.1e-13 50.2 1.6 1e-12 48.5 1.6 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AMD20795.1 - 1.2e-07 31.4 0.1 4.3e-05 23.0 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AMD20795.1 - 5e-07 29.8 0.0 1.9e-06 28.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 AMD20795.1 - 0.0041 17.7 0.4 0.018 15.6 0.2 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 AMD20795.1 - 0.0066 16.3 0.1 0.016 15.1 0.1 1.6 1 0 0 1 1 1 1 AAA lid domain zf-HYPF PF07503.12 AMD20795.1 - 0.014 15.2 0.3 0.014 15.2 0.3 1.8 2 0 0 2 2 2 0 HypF finger AAA_3 PF07726.11 AMD20795.1 - 0.017 15.0 0.0 0.055 13.3 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF1732 PF08340.11 AMD20795.1 - 0.09 12.8 0.3 0.25 11.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) AAA_16 PF13191.6 AMD20795.1 - 0.22 11.9 0.7 3.9 7.8 0.0 3.0 2 2 0 3 3 3 0 AAA ATPase domain COX7C PF02935.16 AMD20796.1 - 0.0017 18.5 0.5 0.0024 18.1 0.5 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIIc DER1 PF04511.15 AMD20798.1 - 4.3e-06 26.8 9.5 4.9e-06 26.6 9.5 1.0 1 0 0 1 1 1 1 Der1-like family polyprenyl_synt PF00348.17 AMD20799.1 - 1.4e-58 198.0 0.0 1.6e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase VPS9 PF02204.18 AMD20800.1 - 2e-16 60.1 1.0 4.4e-16 59.0 1.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain BEN PF10523.9 AMD20800.1 - 0.18 12.1 0.8 1.4 9.2 0.1 2.3 2 0 0 2 2 2 0 BEN domain SH3_1 PF00018.28 AMD20802.1 - 3.2e-22 77.9 0.0 8.6e-11 41.3 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 AMD20802.1 - 1.2e-14 53.9 1.6 4.3e-10 39.3 0.1 2.7 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.24 AMD20802.1 - 3.5e-14 52.7 0.0 7.5e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 AMD20802.1 - 5.9e-06 25.9 0.0 3.9e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain PB1 PF00564.24 AMD20802.1 - 0.058 13.3 0.0 0.18 11.8 0.0 1.9 1 0 0 1 1 1 0 PB1 domain UCH PF00443.29 AMD20803.1 - 4.5e-36 124.7 5.6 5.9e-34 117.7 3.5 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase AAA PF00004.29 AMD20804.1 - 6.5e-39 133.4 0.0 2e-38 131.8 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD20804.1 - 4.1e-10 39.3 0.0 1.1e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 AMD20804.1 - 1.3e-05 25.0 0.0 2.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 AMD20804.1 - 1.8e-05 24.7 0.0 5.4e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 AMD20804.1 - 0.00015 21.1 0.0 0.00029 20.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 AMD20804.1 - 0.00017 21.9 0.2 0.0073 16.6 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 AMD20804.1 - 0.00058 20.0 0.0 0.0029 17.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AMD20804.1 - 0.0011 19.4 0.1 0.0065 16.9 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 AMD20804.1 - 0.0027 17.5 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 AMD20804.1 - 0.0032 18.0 1.4 0.0083 16.7 0.1 2.5 2 1 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 AMD20804.1 - 0.0038 16.6 0.1 0.0087 15.5 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AMD20804.1 - 0.0039 17.2 0.0 0.016 15.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TniB PF05621.11 AMD20804.1 - 0.0059 16.0 0.0 1.6 8.1 0.0 2.6 1 1 1 2 2 2 1 Bacterial TniB protein FAM70 PF14967.6 AMD20804.1 - 0.007 15.9 1.0 0.012 15.1 1.0 1.3 1 0 0 1 1 1 1 FAM70 protein AAA_24 PF13479.6 AMD20804.1 - 0.016 15.0 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AMD20804.1 - 0.025 14.2 0.0 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AMD20804.1 - 0.026 14.7 0.0 0.062 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 AMD20804.1 - 0.033 13.4 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 AMD20804.1 - 0.034 13.7 0.0 0.079 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 AMD20804.1 - 0.054 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 AMD20804.1 - 0.058 13.3 3.7 8.7 6.2 0.0 3.8 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 AMD20804.1 - 0.095 13.1 0.0 0.27 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain Chromo PF00385.24 AMD20804.1 - 0.1 12.5 1.3 0.17 11.8 0.1 2.0 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain Sigma54_activat PF00158.26 AMD20804.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain GCR1_C PF12550.8 AMD20805.1 - 9.9e-26 89.9 2.2 2.4e-25 88.6 2.2 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes NDC10_II PF16787.5 AMD20805.1 - 6.7e-07 28.7 2.1 0.001 18.2 0.1 2.3 1 1 1 2 2 2 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 DUF5082 PF16888.5 AMD20805.1 - 0.46 10.8 4.2 0.18 12.1 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) WD40 PF00400.32 AMD20806.1 - 4.2e-55 182.5 18.4 2.1e-10 41.0 0.1 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 AMD20806.1 - 6.3e-43 146.1 1.2 9.9e-43 145.5 1.2 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 AMD20806.1 - 2.1e-17 63.2 0.1 0.06 13.6 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AMD20806.1 - 1.5e-08 34.3 0.0 0.0023 17.3 0.0 4.0 2 1 2 4 4 4 2 WD40-like domain LisH PF08513.11 AMD20806.1 - 1.1e-06 28.4 0.1 2.2e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 AMD20806.1 - 3e-05 23.1 0.0 0.39 9.6 0.0 3.4 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 AMD20806.1 - 0.0035 16.1 0.7 1.4 7.5 0.1 2.8 2 2 0 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 AMD20806.1 - 0.017 15.0 0.0 0.36 10.7 0.0 2.7 1 1 2 3 3 3 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 AMD20806.1 - 0.1 12.6 0.1 20 5.3 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat GPI2 PF06432.11 AMD20807.1 - 3.6e-52 177.6 25.6 7.4e-52 176.5 25.6 1.5 1 1 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase STI1 PF17830.1 AMD20807.1 - 0.16 11.9 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 STI1 domain UPF0060 PF02694.15 AMD20807.1 - 1.3 9.3 8.0 0.28 11.4 0.3 2.6 1 1 1 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family DUF5315 PF17242.2 AMD20808.1 - 8e-21 73.7 0.2 1.1e-20 73.3 0.2 1.2 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) Mad3_BUB1_I_2 PF17014.5 AMD20808.1 - 0.093 12.9 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein PGI PF00342.19 AMD20809.1 - 1.2e-246 819.0 5.4 1.4e-246 818.8 5.4 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase SAP30_Sin3_bdg PF13867.6 AMD20809.1 - 0.068 13.5 0.2 24 5.4 0.0 2.9 3 0 0 3 3 3 0 Sin3 binding region of histone deacetylase complex subunit SAP30 CAF1C_H4-bd PF12265.8 AMD20810.1 - 1.5e-16 60.4 1.2 5.2e-16 58.7 1.2 2.0 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AMD20810.1 - 1.2e-08 35.5 15.7 0.018 15.9 0.1 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Yopt PF09467.10 AMD20810.1 - 0.17 12.0 0.1 0.41 10.7 0.1 1.7 1 0 0 1 1 1 0 Hypothetical protein Yopt Mt_ATP-synt_B PF05405.14 AMD20811.1 - 3e-51 173.3 9.5 3.5e-51 173.0 9.5 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Cas_Csd1 PF09709.10 AMD20811.1 - 0.019 13.7 0.3 0.021 13.5 0.3 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csd1) Rep_trans PF02486.19 AMD20811.1 - 0.02 14.6 1.3 0.034 13.9 1.3 1.3 1 1 0 1 1 1 0 Replication initiation factor DUF5623 PF18536.1 AMD20811.1 - 0.14 12.5 0.7 0.51 10.6 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5623) Fib_alpha PF08702.10 AMD20811.1 - 0.8 9.9 6.7 1.9 8.7 6.4 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 AMD20811.1 - 3.2 7.6 7.1 0.89 9.4 0.9 2.6 2 1 0 2 2 2 0 Septum formation initiator Med8 PF10232.9 AMD20812.1 - 1.3e-16 60.9 0.8 1.7e-16 60.5 0.8 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 G10 PF01125.17 AMD20812.1 - 0.038 13.8 0.1 0.098 12.4 0.1 1.6 2 0 0 2 2 2 0 G10 protein DASH_Hsk3 PF08227.11 AMD20812.1 - 0.36 11.2 2.8 1.8 9.0 1.3 2.4 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like Mito_carr PF00153.27 AMD20813.1 - 1.4e-76 252.5 0.6 2.9e-26 91.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 AMD20813.1 - 0.0032 17.6 0.0 0.47 10.7 0.0 3.1 3 0 0 3 3 3 1 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Ribosomal_L21e PF01157.18 AMD20814.1 - 3.1e-48 161.8 5.0 3.1e-48 161.8 5.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 AMD20814.1 - 0.006 16.2 0.0 0.0073 15.9 0.0 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 SIMPL PF04402.14 AMD20814.1 - 0.044 14.2 0.2 0.058 13.9 0.2 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF541) S4 PF01479.25 AMD20815.1 - 3.4e-11 42.7 0.3 3.4e-11 42.7 0.3 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 AMD20815.1 - 6.3e-05 23.8 0.2 9.2e-05 23.3 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain DUF3535 PF12054.8 AMD20816.1 - 7.6e-118 394.5 10.0 1.2e-116 390.5 1.2 5.0 6 0 0 6 6 6 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 AMD20816.1 - 1.5e-67 227.8 0.0 2.6e-67 227.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD20816.1 - 2.1e-18 66.7 0.1 1e-17 64.5 0.0 2.3 3 0 0 3 3 2 1 Helicase conserved C-terminal domain HEAT PF02985.22 AMD20816.1 - 9.7e-14 50.3 0.5 0.5 10.8 0.0 8.4 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 AMD20816.1 - 8.7e-05 22.8 2.7 1.3 9.4 0.0 6.2 5 2 1 6 6 6 1 HEAT repeats HEAT_EZ PF13513.6 AMD20816.1 - 0.00012 22.5 7.1 1.2 9.7 0.0 7.3 9 0 0 9 9 9 1 HEAT-like repeat ResIII PF04851.15 AMD20816.1 - 0.00037 20.5 0.0 0.0017 18.4 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TAF6_C PF07571.13 AMD20816.1 - 0.0032 17.8 0.5 0.9 9.9 0.0 4.5 5 0 0 5 5 4 1 TAF6 C-terminal HEAT repeat domain ERCC3_RAD25_C PF16203.5 AMD20816.1 - 0.0047 16.2 0.0 0.013 14.8 0.0 1.7 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HEPN PF05168.14 AMD20816.1 - 0.19 11.9 2.5 1.4 9.1 0.3 3.2 3 0 0 3 3 3 0 HEPN domain U3snoRNP10 PF12397.8 AMD20816.1 - 0.33 11.3 4.6 0.29 11.5 0.2 3.2 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 10 TAFH PF07531.14 AMD20816.1 - 0.53 10.4 3.7 15 5.7 0.1 4.0 4 0 0 4 4 4 0 NHR1 homology to TAF cwf18 PF08315.12 AMD20817.1 - 1.9e-07 31.8 0.3 2.1e-07 31.7 0.3 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Asp-B-Hydro_N PF05279.11 AMD20817.1 - 0.056 13.5 0.1 0.062 13.4 0.1 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region UPF0016 PF01169.19 AMD20818.1 - 1.5e-42 143.8 23.0 1.6e-21 76.4 8.9 2.4 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 LysE PF01810.18 AMD20818.1 - 0.01 15.3 11.1 0.11 12.0 1.4 2.4 2 0 0 2 2 2 0 LysE type translocator DUF4131 PF13567.6 AMD20818.1 - 0.074 12.7 1.9 3.2 7.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) AAA PF00004.29 AMD20819.1 - 2e-31 109.2 0.0 4.5e-31 108.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD20819.1 - 1.4e-08 35.1 0.1 4.8e-08 33.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.6 AMD20819.1 - 3.6e-07 30.3 0.0 7.9e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AMD20819.1 - 6.5e-06 26.6 0.1 2.5e-05 24.7 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AMD20819.1 - 2.2e-05 25.0 0.0 0.00012 22.6 0.0 2.4 3 0 0 3 3 1 1 AAA domain AAA_24 PF13479.6 AMD20819.1 - 5.6e-05 22.9 0.0 0.00017 21.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AMD20819.1 - 0.00011 22.0 0.0 0.00019 21.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD20819.1 - 0.00031 21.1 0.6 0.0041 17.4 0.6 2.4 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 AMD20819.1 - 0.0004 20.4 0.0 0.0019 18.2 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain RNA_helicase PF00910.22 AMD20819.1 - 0.00044 20.6 0.0 0.0029 18.0 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 AMD20819.1 - 0.00061 20.0 0.0 0.0021 18.2 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_7 PF12775.7 AMD20819.1 - 0.00074 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 AMD20819.1 - 0.00076 18.6 0.0 0.0018 17.4 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein RuvB_N PF05496.12 AMD20819.1 - 0.00086 19.1 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 AMD20819.1 - 0.00099 19.1 0.3 0.0073 16.2 0.2 2.3 1 1 1 2 2 2 1 NACHT domain AAA_14 PF13173.6 AMD20819.1 - 0.0012 18.9 0.1 0.0039 17.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 AMD20819.1 - 0.0019 17.9 0.0 0.0036 17.0 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 AMD20819.1 - 0.0024 17.9 0.2 0.024 14.6 0.1 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) cobW PF02492.19 AMD20819.1 - 0.003 17.2 1.4 0.56 9.8 0.0 2.8 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 AMD20819.1 - 0.0038 17.7 0.2 0.011 16.2 0.0 1.9 2 1 1 3 3 1 1 ABC transporter AAA_25 PF13481.6 AMD20819.1 - 0.0077 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 AMD20819.1 - 0.0078 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Cytidylate_kin PF02224.18 AMD20819.1 - 0.0096 15.7 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Cytidylate kinase TsaE PF02367.17 AMD20819.1 - 0.012 15.6 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 AMD20819.1 - 0.013 15.2 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 AMD20819.1 - 0.015 15.3 0.1 0.2 11.5 0.1 2.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 AMD20819.1 - 0.015 15.8 2.5 0.019 15.5 0.1 2.4 1 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 AMD20819.1 - 0.016 14.6 0.1 0.11 11.8 0.1 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 AMD20819.1 - 0.019 14.9 0.1 0.04 13.8 0.1 1.5 1 0 0 1 1 1 0 NTPase AAA_6 PF12774.7 AMD20819.1 - 0.026 13.5 0.0 0.051 12.5 0.0 1.5 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_28 PF13521.6 AMD20819.1 - 0.027 14.7 0.3 0.063 13.5 0.1 1.7 2 0 0 2 2 1 0 AAA domain Viral_helicase1 PF01443.18 AMD20819.1 - 0.028 14.2 0.0 0.07 12.9 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 AMD20819.1 - 0.032 13.6 0.1 0.095 12.0 0.0 1.7 2 0 0 2 2 2 0 KaiC AAA_17 PF13207.6 AMD20819.1 - 0.044 14.2 0.1 0.11 12.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 AMD20819.1 - 0.049 13.8 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain ResIII PF04851.15 AMD20819.1 - 0.084 12.9 0.1 0.59 10.1 0.0 2.1 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit P53_TAD PF08563.11 AMD20819.1 - 0.15 11.6 0.2 0.15 11.6 0.2 1.8 2 0 0 2 2 1 0 P53 transactivation motif tRNA_int_end_N2 PF12928.7 AMD20820.1 - 3.2e-17 62.5 0.0 6.1e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Casein_kappa PF00997.18 AMD20820.1 - 0.38 10.8 1.5 0.71 10.0 1.5 1.3 1 0 0 1 1 1 0 Kappa casein BRO1 PF03097.18 AMD20821.1 - 5.4e-85 285.5 4.8 5.4e-85 285.5 4.8 2.1 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 AMD20821.1 - 1.6e-23 83.5 10.1 3.7e-23 82.3 9.6 1.9 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV ABC2_membrane_3 PF12698.7 AMD20821.1 - 0.001 18.2 1.3 0.001 18.2 1.3 2.0 2 0 0 2 2 2 1 ABC-2 family transporter protein MBA1 PF07961.11 AMD20822.1 - 4.1e-93 310.8 1.7 5e-93 310.5 1.7 1.1 1 0 0 1 1 1 1 MBA1-like protein Sec16_C PF12931.7 AMD20823.1 - 4.6e-66 223.5 0.0 1e-65 222.4 0.0 1.6 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 AMD20823.1 - 1.2e-06 29.1 0.0 1.2e-06 29.1 0.0 3.5 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region Radical_SAM_C PF16199.5 AMD20824.1 - 1.9e-32 111.1 0.0 3.7e-32 110.2 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 AMD20824.1 - 5e-19 69.3 0.5 2.8e-18 66.9 0.1 2.3 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 AMD20824.1 - 1.4e-09 38.2 0.1 2.5e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AMD20824.1 - 1.8e-06 27.9 0.0 4.9e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AMD20824.1 - 0.02 15.3 0.1 0.043 14.2 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ceramidase PF05875.12 AMD20825.1 - 4.3e-89 298.4 16.4 5e-89 298.2 16.4 1.0 1 0 0 1 1 1 1 Ceramidase SLATT_4 PF18186.1 AMD20825.1 - 0.019 14.6 0.5 0.03 13.9 0.5 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 DUF3792 PF12670.7 AMD20825.1 - 0.031 14.4 0.8 0.031 14.4 0.8 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3792) KbaA PF14089.6 AMD20825.1 - 0.034 14.0 7.5 0.1 12.4 1.4 2.6 2 1 0 2 2 2 0 KinB-signalling pathway activation in sporulation Halogen_Hydrol PF10112.9 AMD20825.1 - 1.3 9.0 3.4 7.8 6.5 0.4 2.5 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein ECF_trnsprt PF12822.7 AMD20825.1 - 8 6.5 14.4 1e+03 -0.4 14.5 2.7 1 1 0 1 1 1 0 ECF transporter, substrate-specific component MerC PF03203.14 AMD20825.1 - 8.7 6.8 12.7 25 5.4 0.5 2.7 1 1 1 2 2 2 0 MerC mercury resistance protein SRF-TF PF00319.18 AMD20826.1 - 2.4e-20 71.7 1.4 6.6e-20 70.3 0.1 2.2 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Utp14 PF04615.13 AMD20826.1 - 0.029 13.0 18.7 0.048 12.2 18.7 1.4 1 0 0 1 1 1 0 Utp14 protein Ribosomal_S6e PF01092.19 AMD20827.1 - 2.5e-57 192.2 0.4 2.5e-57 192.2 0.4 1.6 2 1 0 2 2 2 1 Ribosomal protein S6e Caps_synth_GfcC PF06251.11 AMD20827.1 - 0.18 11.4 1.8 0.27 10.8 1.8 1.2 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Pyr_redox_2 PF07992.14 AMD20828.1 - 1.5e-61 208.2 0.8 2.3e-61 207.6 0.8 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AMD20828.1 - 1.8e-34 118.3 0.2 1.1e-33 115.7 0.1 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AMD20828.1 - 9e-19 67.8 2.8 1.1e-17 64.3 0.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AMD20828.1 - 2.8e-14 53.1 2.5 1.1e-13 51.1 2.5 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AMD20828.1 - 1.3e-08 34.0 1.5 0.0038 16.0 0.0 3.1 3 0 0 3 3 3 3 HI0933-like protein FAD_oxidored PF12831.7 AMD20828.1 - 0.00013 21.5 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 AMD20828.1 - 0.0014 18.0 0.1 0.9 8.8 0.1 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 AMD20828.1 - 0.0021 17.2 3.7 0.0039 16.3 2.4 2.2 2 1 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 AMD20828.1 - 0.0024 17.0 5.3 0.038 13.1 1.6 2.8 3 0 0 3 3 3 1 FAD binding domain K_oxygenase PF13434.6 AMD20828.1 - 0.0025 17.0 0.0 0.027 13.6 0.0 2.1 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) 2-Hacid_dh_C PF02826.19 AMD20828.1 - 0.0055 16.1 0.9 0.28 10.5 0.0 2.9 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 AMD20828.1 - 0.031 14.2 0.0 0.031 14.2 0.0 2.2 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 AMD20828.1 - 0.089 12.0 1.8 7.5 5.7 0.4 2.3 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 AMD20828.1 - 0.32 10.5 6.8 6.8 6.2 0.0 3.0 2 1 0 3 3 3 0 FAD dependent oxidoreductase MFS_1 PF07690.16 AMD20829.1 - 6.9e-44 150.2 32.3 2.9e-43 148.1 21.5 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AMD20829.1 - 2.3e-17 63.0 22.8 2.1e-16 59.9 1.6 3.5 3 1 0 3 3 3 3 Sugar (and other) transporter MFS_4 PF06779.14 AMD20829.1 - 7.4e-05 22.2 5.3 0.00017 21.0 5.3 1.5 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB NOG1_N PF17835.1 AMD20830.1 - 4.9e-51 172.9 2.8 2.2e-50 170.8 0.1 2.6 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 AMD20830.1 - 1.8e-26 91.9 1.9 4.4e-26 90.6 0.6 2.4 1 1 1 2 2 2 1 NOGCT (NUC087) domain NOG1 PF06858.14 AMD20830.1 - 5.1e-25 87.0 0.3 1.6e-24 85.5 0.3 1.9 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 AMD20830.1 - 1.3e-16 60.6 0.0 4.5e-16 59.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD20830.1 - 7.2e-09 35.4 0.1 1.7e-08 34.2 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AMD20830.1 - 0.00019 21.4 0.4 0.49 10.3 0.1 3.1 3 0 0 3 3 3 2 RsgA GTPase Gtr1_RagA PF04670.12 AMD20830.1 - 0.0055 16.1 0.2 0.0098 15.3 0.2 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 AMD20830.1 - 0.012 15.6 2.0 3.4 7.7 0.0 3.1 2 1 1 3 3 3 0 Dynamin family AAA_16 PF13191.6 AMD20830.1 - 0.055 13.8 0.0 0.56 10.6 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 AMD20830.1 - 0.058 13.6 0.0 0.2 11.9 0.0 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Sec62 PF03839.16 AMD20831.1 - 8.4e-76 254.3 0.4 1e-75 254.0 0.4 1.0 1 0 0 1 1 1 1 Translocation protein Sec62 TNFR_16_TM PF18422.1 AMD20831.1 - 0.017 15.0 0.7 0.055 13.4 0.7 1.9 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF2628 PF10947.8 AMD20831.1 - 8.2 6.9 9.0 15 6.0 9.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Dynamin_N PF00350.23 AMD20832.1 - 3.9e-18 66.1 0.2 3.9e-18 66.1 0.2 1.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 AMD20832.1 - 8.3e-11 42.0 0.1 5.2e-10 39.4 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AMD20832.1 - 1.1e-09 38.2 0.9 2.4e-06 27.2 0.7 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain cobW PF02492.19 AMD20832.1 - 0.00036 20.1 4.5 0.014 15.0 0.6 3.1 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 AMD20832.1 - 0.00087 19.0 0.8 0.81 9.4 0.3 3.0 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 AMD20832.1 - 0.009 16.6 0.2 0.19 12.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain TniB PF05621.11 AMD20832.1 - 0.011 15.2 0.1 0.067 12.6 0.0 2.3 3 0 0 3 3 3 0 Bacterial TniB protein FeoB_N PF02421.18 AMD20832.1 - 0.047 13.2 1.2 7.8 6.0 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B TsaE PF02367.17 AMD20832.1 - 0.049 13.6 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 AMD20832.1 - 0.055 13.4 8.0 1.1 9.2 0.0 3.7 3 1 1 4 4 4 0 RsgA GTPase AAA_16 PF13191.6 AMD20832.1 - 0.1 13.0 0.0 0.34 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain Abhydrolase_1 PF00561.20 AMD20833.1 - 4.7e-15 55.9 0.0 1.5e-14 54.2 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AMD20833.1 - 5.1e-08 32.5 0.0 1.5e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Rad4 PF03835.15 AMD20834.1 - 2.4e-13 50.0 1.3 7.7e-13 48.4 1.0 2.0 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 AMD20834.1 - 1.1e-09 38.7 0.2 2.1e-09 37.8 0.2 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Zn_ribbon_SprT PF17283.2 AMD20834.1 - 0.002 18.0 1.9 0.0048 16.8 1.9 1.6 1 0 0 1 1 1 1 SprT-like zinc ribbon domain zf-B_box PF00643.24 AMD20834.1 - 0.085 13.0 5.9 0.41 10.8 1.0 3.0 3 0 0 3 3 3 0 B-box zinc finger PAW PF04721.17 AMD20834.1 - 0.087 12.6 0.7 0.18 11.5 0.7 1.6 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW Ogr_Delta PF04606.12 AMD20834.1 - 0.19 11.7 3.4 0.5 10.4 3.4 1.7 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger PIG-Y PF15159.6 AMD20835.1 - 0.00094 20.1 11.0 0.0014 19.5 11.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF5079 PF16882.5 AMD20835.1 - 0.03 14.2 0.2 0.031 14.2 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5079) tRNA-synt_1b PF00579.25 AMD20836.1 - 2.1e-73 247.2 0.0 2.6e-73 246.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 AMD20836.1 - 0.0034 17.2 0.4 0.049 13.4 0.4 2.3 1 1 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain Romo1 PF10247.9 AMD20837.1 - 1.3e-28 99.1 9.9 1.6e-28 98.8 9.9 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 DUF2700 PF10912.8 AMD20837.1 - 0.15 12.1 0.2 0.39 10.8 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2700) ERM PF00769.19 AMD20838.1 - 0.26 11.1 7.3 0.38 10.5 7.3 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family CHIP_TPR_N PF18391.1 AMD20838.1 - 0.49 11.2 5.5 0.19 12.5 1.6 2.1 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain Nucleoporin_N PF08801.11 AMD20839.1 - 1.5e-05 23.9 1.1 0.14 10.8 0.0 3.6 1 1 3 4 4 4 3 Nup133 N terminal like WD40 PF00400.32 AMD20839.1 - 1.9e-05 25.3 0.4 0.038 14.9 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20839.1 - 0.00034 20.9 0.1 1.6 9.1 0.0 3.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 AMD20839.1 - 0.0048 16.2 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller PAXNEB PF05625.11 AMD20840.1 - 2.2e-88 296.9 0.5 2.6e-88 296.7 0.5 1.1 1 0 0 1 1 1 1 PAXNEB protein Lipoprotein_3 PF00938.17 AMD20840.1 - 0.18 12.0 0.2 1.2 9.4 0.0 2.3 3 0 0 3 3 3 0 Lipoprotein dsrm PF00035.26 AMD20841.1 - 8e-08 32.9 0.0 1.6e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 AMD20841.1 - 0.0023 18.5 0.0 0.0056 17.3 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease III domain FAM86 PF14904.6 AMD20842.1 - 0.024 14.7 0.1 0.52 10.4 0.0 2.3 1 1 1 2 2 2 0 Family of unknown function OrfB_IS605 PF01385.19 AMD20842.1 - 0.032 14.4 0.0 0.056 13.7 0.0 1.3 1 0 0 1 1 1 0 Probable transposase Pex2_Pex12 PF04757.14 AMD20843.1 - 1.5e-31 109.7 6.6 1.8e-31 109.5 6.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 AMD20843.1 - 3.3e-06 26.9 0.6 5.6e-06 26.1 0.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD20843.1 - 0.01 15.7 0.8 0.019 14.8 0.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD20843.1 - 0.06 13.2 0.7 0.11 12.4 0.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AMD20843.1 - 0.14 12.5 1.0 0.29 11.5 1.0 1.5 1 0 0 1 1 1 0 Ring finger domain Zn_Tnp_IS1595 PF12760.7 AMD20843.1 - 0.16 12.0 0.9 0.66 10.0 0.4 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-C3HC4_4 PF15227.6 AMD20843.1 - 0.62 10.3 4.5 1.3 9.3 4.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING F_bP_aldolase PF01116.20 AMD20844.1 - 2e-89 299.8 0.0 2.3e-89 299.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Cas_GSU0053 PF09617.10 AMD20844.1 - 0.17 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) DUF89 PF01937.19 AMD20845.1 - 2.3e-103 345.8 0.2 2.6e-103 345.7 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DWNN PF08783.11 AMD20846.1 - 1.3e-29 102.3 0.3 1.3e-29 102.3 0.3 1.8 2 0 0 2 2 2 1 DWNN domain zf-CCHC_2 PF13696.6 AMD20846.1 - 8e-08 32.0 8.4 3.6e-07 29.9 7.0 2.2 2 0 0 2 2 2 1 Zinc knuckle U-box PF04564.15 AMD20846.1 - 1.5e-05 25.1 0.0 0.00021 21.4 0.0 2.4 2 0 0 2 2 2 1 U-box domain zf-CCHC PF00098.23 AMD20846.1 - 0.00095 19.1 3.3 0.0017 18.3 3.3 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-Nse PF11789.8 AMD20846.1 - 0.0058 16.4 0.2 0.015 15.1 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Rubredoxin PF00301.20 AMD20846.1 - 0.02 14.9 3.3 0.45 10.6 0.0 3.0 3 0 0 3 3 3 0 Rubredoxin zf-CCHC_3 PF13917.6 AMD20846.1 - 0.021 14.8 0.1 0.037 14.0 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 AMD20846.1 - 0.11 12.3 0.5 0.28 10.9 0.5 1.7 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger TFIIA_gamma_C PF02751.14 AMD20847.1 - 8.4e-24 83.5 2.1 1.3e-23 82.9 2.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 AMD20847.1 - 2.6e-23 81.7 0.4 3.6e-23 81.3 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TAP42 PF04177.12 AMD20848.1 - 1.1e-82 277.8 13.5 1.2e-82 277.6 13.5 1.0 1 0 0 1 1 1 1 TAP42-like family Nucleoporin2 PF04096.14 AMD20848.1 - 0.029 14.5 0.2 0.057 13.5 0.2 1.5 1 0 0 1 1 1 0 Nucleoporin autopeptidase Nup160 PF11715.8 AMD20849.1 - 1.2e-17 63.8 0.2 4.5e-17 61.9 0.1 1.8 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Striatin PF08232.12 AMD20850.1 - 1.9e-20 74.1 4.4 1e-19 71.6 1.0 2.4 1 1 1 2 2 2 1 Striatin family GIT1_C PF12205.8 AMD20850.1 - 0.079 13.1 0.3 0.16 12.1 0.3 1.5 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Mto2_bdg PF12808.7 AMD20850.1 - 0.095 13.0 1.6 0.2 12.0 1.6 1.5 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Herpes_BLRF2 PF05812.12 AMD20850.1 - 0.17 12.0 0.6 1.6 8.9 0.3 2.4 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein TCTP PF00838.17 AMD20851.1 - 3.8e-74 248.5 1.6 4.2e-74 248.4 1.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein adh_short PF00106.25 AMD20852.1 - 8.1e-30 103.7 0.8 3e-22 79.0 0.7 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AMD20852.1 - 4.9e-15 55.7 0.1 2.8e-14 53.2 0.1 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ThrE_2 PF12821.7 AMD20852.1 - 0.014 15.5 0.3 0.025 14.7 0.3 1.4 1 0 0 1 1 1 0 Threonine/Serine exporter, ThrE KR PF08659.10 AMD20852.1 - 0.12 12.3 0.1 0.55 10.1 0.0 1.9 2 0 0 2 2 2 0 KR domain CUE PF02845.16 AMD20853.1 - 0.064 13.0 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 CUE domain Herpes_UL49_2 PF04823.12 AMD20853.1 - 5.9 7.1 10.2 1.4 9.0 1.5 3.4 2 0 0 2 2 2 0 Herpesvirus UL49 tegument protein UPF0203 PF05254.12 AMD20854.1 - 3.5e-28 97.6 4.8 4.1e-28 97.4 4.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 AMD20854.1 - 1.6e-05 25.0 4.0 1.6e-05 25.0 3.3 1.4 1 1 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 AMD20854.1 - 0.0011 19.0 1.9 0.044 13.8 0.1 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 AMD20854.1 - 0.078 12.7 4.1 3.8 7.3 0.6 2.1 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DASH_Ask1 PF08655.10 AMD20855.1 - 5e-29 100.0 0.3 1.3e-28 98.6 0.3 1.8 2 0 0 2 2 2 1 DASH complex subunit Ask1 Frag1 PF10277.9 AMD20856.1 - 2.4e-76 256.1 23.6 2.8e-76 255.9 23.6 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Eisosome1 PF12757.7 AMD20857.1 - 1.9e-29 102.4 3.3 1.9e-29 102.4 3.3 4.5 2 1 0 2 2 2 1 Eisosome protein 1 Serine_rich PF08824.10 AMD20857.1 - 1.7 8.7 14.7 0.43 10.6 9.7 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain FCH PF00611.23 AMD20858.1 - 9.8e-11 41.8 0.0 9.8e-11 41.8 0.0 3.2 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 AMD20858.1 - 1.8e-08 34.1 0.1 3.3e-08 33.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AMD20858.1 - 1.2e-07 31.3 0.1 2.2e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AMD20858.1 - 2.2e-06 27.3 0.0 4.6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Histone PF00125.24 AMD20859.1 - 2.9e-37 127.9 1.6 2.9e-37 127.9 1.6 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AMD20859.1 - 0.0025 17.9 0.7 0.0052 16.9 0.1 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 AMD20859.1 - 0.0087 16.4 0.1 0.018 15.4 0.1 1.5 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 AMD20859.1 - 0.12 12.6 0.1 2.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Actin PF00022.19 AMD20860.1 - 4.4e-22 78.3 0.4 2.7e-19 69.1 0.0 2.8 2 1 0 2 2 2 2 Actin SBF_like PF13593.6 AMD20861.1 - 4.5e-102 341.6 13.6 5.2e-102 341.3 13.6 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 AMD20861.1 - 1.6e-12 47.5 7.2 1.6e-12 47.5 7.2 1.9 1 1 1 2 2 2 1 Sodium Bile acid symporter family EVC2_like PF12297.8 AMD20861.1 - 4.3 5.9 3.9 2.9 6.5 0.3 2.0 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein Peptidase_S24 PF00717.23 AMD20862.1 - 2.1e-07 30.8 0.0 4.3e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 AMD20862.1 - 1e-05 25.3 0.0 0.00037 20.3 0.0 2.2 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Rhodanese PF00581.20 AMD20863.1 - 3.2e-08 34.0 0.0 7.6e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 AMD20864.1 - 1.9e-31 109.4 0.0 6e-28 97.9 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20864.1 - 1.7e-16 60.3 0.0 2.3e-12 46.8 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Kinase-like PF14531.6 AMD20864.1 - 0.00045 19.6 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 AMD20864.1 - 0.0032 17.4 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-C2H2 PF00096.26 AMD20865.1 - 4.7e-13 48.8 13.2 3.2e-06 27.3 3.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD20865.1 - 3.8e-09 36.6 12.3 0.0001 22.8 1.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AMD20865.1 - 7.8e-07 29.3 19.3 1.4e-05 25.3 3.3 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AMD20865.1 - 1.6e-05 25.0 13.4 0.0011 19.2 2.2 2.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 AMD20865.1 - 1.8e-05 24.7 5.2 0.044 13.8 1.0 2.7 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.6 AMD20865.1 - 0.00012 22.0 12.1 0.00036 20.5 3.3 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2HE PF16278.5 AMD20865.1 - 0.0031 17.9 8.4 0.38 11.2 1.0 2.7 1 1 1 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 AMD20865.1 - 0.11 12.9 5.0 1.2 9.7 0.7 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 AMD20865.1 - 0.14 12.5 3.9 0.28 11.5 3.9 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 AMD20865.1 - 0.17 12.6 1.2 1 10.1 1.2 2.3 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 AMD20865.1 - 0.21 11.9 6.3 0.68 10.3 0.6 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-AN1 PF01428.16 AMD20865.1 - 0.35 11.1 2.3 21 5.4 0.1 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger zf-C2H2_11 PF16622.5 AMD20865.1 - 0.4 10.5 4.3 1.5 8.6 0.3 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf_C2H2_ZHX PF18387.1 AMD20865.1 - 0.83 9.3 4.6 8.7 6.1 0.4 2.6 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_5 PF13909.6 AMD20865.1 - 1.1 9.0 20.5 0.14 11.9 3.2 3.4 2 1 0 2 2 2 0 C2H2-type zinc-finger domain Actin_micro PF17003.5 AMD20865.1 - 2.6 7.2 5.2 28 3.7 5.2 2.2 1 1 0 1 1 1 0 Putative actin-like family HNH PF01844.23 AMD20865.1 - 3.4 7.9 6.7 4.4 7.5 0.9 2.5 2 0 0 2 2 2 0 HNH endonuclease PyrI_C PF02748.15 AMD20865.1 - 8.4 6.4 6.1 1.2 9.1 0.3 2.4 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Seryl_tRNA_N PF02403.22 AMD20866.1 - 0.054 13.7 2.1 0.075 13.3 2.1 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HMA PF00403.26 AMD20867.1 - 2.9e-12 46.9 0.2 1.5e-11 44.6 0.1 2.0 2 0 0 2 2 2 1 Heavy-metal-associated domain Sod_Cu PF00080.20 AMD20867.1 - 0.0037 17.4 0.0 0.0067 16.6 0.0 1.4 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CorA PF01544.18 AMD20868.1 - 1.7e-39 135.9 4.0 6.9e-23 81.4 0.8 3.4 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein PC4 PF02229.16 AMD20869.1 - 3e-23 81.2 0.0 7.2e-23 80.0 0.0 1.7 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) NusB PF01029.18 AMD20869.1 - 0.13 12.5 0.5 15 5.9 0.0 2.3 2 0 0 2 2 2 0 NusB family Aldo_ket_red PF00248.21 AMD20870.1 - 6.1e-46 156.9 0.0 7.4e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Bap31 PF05529.12 AMD20871.1 - 4.6e-25 88.0 1.2 8.1e-25 87.2 1.2 1.4 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region ADIP PF11559.8 AMD20871.1 - 6.8e-05 23.0 1.9 8.6e-05 22.7 1.9 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Bap31_Bap29_C PF18035.1 AMD20871.1 - 0.0086 16.1 12.5 0.017 15.1 12.5 1.5 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 AMD20871.1 - 0.33 10.8 5.0 0.65 9.8 5.0 1.5 1 0 0 1 1 1 0 Septum formation initiator UPF0242 PF06785.11 AMD20871.1 - 1.1 9.3 7.1 0.082 13.0 2.3 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus NDK PF00334.19 AMD20872.1 - 6e-54 181.7 0.0 6.9e-54 181.5 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PWWP PF00855.17 AMD20873.1 - 1.2e-19 70.5 0.2 3.5e-19 69.0 0.2 1.9 1 0 0 1 1 1 1 PWWP domain InPase PF18823.1 AMD20873.1 - 0.1 12.3 2.1 0.4 10.4 1.5 2.2 1 1 1 2 2 2 0 Inorganic Pyrophosphatase DUF3246 PF11596.8 AMD20873.1 - 1.3 8.5 4.2 2.5 7.5 4.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3246) SRF-TF PF00319.18 AMD20874.1 - 7.5e-21 73.4 0.1 1.1e-20 72.8 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) TFIIE-A_C PF11521.8 AMD20874.1 - 0.0071 16.6 1.7 0.0071 16.6 1.7 2.3 2 0 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha CENP-B_dimeris PF09026.10 AMD20874.1 - 0.19 12.2 5.3 0.39 11.1 5.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Metal_resist PF13801.6 AMD20874.1 - 0.3 11.3 5.3 1.1 9.5 5.3 1.9 1 1 0 1 1 1 0 Heavy-metal resistance MPP6 PF10175.9 AMD20874.1 - 3.1 8.3 6.3 5.1 7.6 6.3 1.3 1 1 0 1 1 1 0 M-phase phosphoprotein 6 Nucleoporin_FG PF13634.6 AMD20875.1 - 4e-55 184.6 367.4 1.6e-13 51.3 38.7 13.2 4 2 9 13 13 13 11 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 AMD20875.1 - 3e-34 118.3 0.0 5.1e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Sorting_nexin PF03700.13 AMD20876.1 - 0.047 14.3 4.0 0.18 12.4 0.6 2.0 1 1 1 2 2 2 0 Sorting nexin, N-terminal domain Cwf_Cwc_15 PF04889.12 AMD20876.1 - 1.3 8.7 5.1 1.5 8.5 5.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Swi3 PF07962.12 AMD20877.1 - 4.1e-27 94.0 0.7 8e-27 93.1 0.7 1.5 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 BOP1NT PF08145.12 AMD20878.1 - 8.8e-104 347.0 7.9 1.3e-103 346.4 7.9 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 AMD20878.1 - 9e-25 86.5 5.9 4.8e-10 39.9 0.5 6.4 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20878.1 - 1.1e-08 35.2 1.0 0.0045 17.2 0.0 5.2 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain GAF_2 PF13185.6 AMD20879.1 - 9.1e-12 45.4 0.0 1.2e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 AMD20879.1 - 1.1e-06 29.4 0.0 1.5e-06 28.8 0.0 1.3 1 1 0 1 1 1 1 GAF domain PG_binding_1 PF01471.18 AMD20881.1 - 5.1e-05 23.4 0.0 0.00083 19.5 0.0 2.5 2 0 0 2 2 2 1 Putative peptidoglycan binding domain COG5 PF10392.9 AMD20881.1 - 0.0099 16.1 0.5 0.021 15.0 0.5 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Lectin_N PF03954.14 AMD20881.1 - 0.02 14.6 2.9 0.1 12.3 0.8 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain THP2 PF09432.10 AMD20881.1 - 0.036 14.1 0.5 0.1 12.7 0.5 1.7 1 0 0 1 1 1 0 Tho complex subunit THP2 TolA_bind_tri PF16331.5 AMD20881.1 - 0.036 14.1 1.5 0.07 13.2 0.9 1.7 1 1 0 1 1 1 0 TolA binding protein trimerisation DUF1664 PF07889.12 AMD20881.1 - 0.041 13.9 0.7 0.097 12.7 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2203 PF09969.9 AMD20881.1 - 0.17 12.6 0.5 0.5 11.1 0.5 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) V_ATPase_I PF01496.19 AMD20882.1 - 1e-298 992.9 6.3 1.2e-298 992.7 6.3 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family HSP70 PF00012.20 AMD20883.1 - 6.4e-46 156.7 0.6 1e-45 156.1 0.0 1.6 1 1 0 1 1 1 1 Hsp70 protein DUF3945 PF13101.6 AMD20883.1 - 0.29 10.9 1.7 6.6 6.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) RRM_1 PF00076.22 AMD20884.1 - 0.015 15.1 0.0 0.046 13.5 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RabGAP-TBC PF00566.18 AMD20885.1 - 1.8e-32 112.8 0.0 2.4e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Cu-oxidase_2 PF07731.14 AMD20886.1 - 3.4e-46 156.4 6.4 2e-40 137.7 0.3 2.7 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AMD20886.1 - 3.6e-42 143.1 2.5 2.2e-40 137.4 0.3 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 AMD20886.1 - 4e-33 114.8 0.6 1.7e-30 106.2 0.3 3.3 3 0 0 3 3 3 2 Multicopper oxidase DNA_pol3_alpha PF07733.12 AMD20887.1 - 0.0028 17.3 0.0 0.006 16.2 0.0 1.6 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha NTPase domain PRA-PH PF01503.17 AMD20887.1 - 0.13 12.8 0.1 0.3 11.6 0.1 1.7 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase His_Phos_2 PF00328.22 AMD20887.1 - 5.6 6.2 7.6 20 4.4 3.4 2.7 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 2) DUF4448 PF14610.6 AMD20888.1 - 2.8e-51 174.0 1.1 4.2e-51 173.4 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF4271 PF14093.6 AMD20888.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) Sen15 PF09631.10 AMD20889.1 - 7.2e-24 84.0 0.1 8.2e-24 83.8 0.1 1.0 1 0 0 1 1 1 1 Sen15 protein Tom37_C PF11801.8 AMD20890.1 - 4.9e-43 146.6 0.7 6.7e-43 146.2 0.7 1.2 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.9 AMD20890.1 - 5.2e-29 101.1 0.6 5.2e-29 101.1 0.6 1.9 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 AMD20890.1 - 0.0014 19.3 0.1 0.05 14.4 0.0 2.9 3 0 0 3 3 3 1 Glutathione S-transferase N-terminal domain Suf PF05843.14 AMD20891.1 - 4.1e-59 201.0 24.9 4.2e-50 171.4 4.9 5.6 4 2 1 6 6 6 3 Suppressor of forked protein (Suf) DUF2795 PF11387.8 AMD20891.1 - 0.025 14.8 0.1 0.12 12.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) TPR_14 PF13428.6 AMD20891.1 - 0.03 15.1 0.3 1.2 10.1 0.0 3.6 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20891.1 - 0.041 14.4 0.1 0.21 12.1 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat FGGY_C PF02782.16 AMD20891.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain ArgJ PF01960.18 AMD20892.1 - 5.8e-134 446.5 3.2 6.5e-134 446.4 3.2 1.0 1 0 0 1 1 1 1 ArgJ family VirC2 PF07181.11 AMD20892.1 - 0.17 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 VirC2 protein Sugar_tr PF00083.24 AMD20893.1 - 7.5e-118 394.2 17.3 8.7e-118 394.0 17.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD20893.1 - 7.7e-24 84.3 24.9 1.9e-17 63.2 7.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OppC_N PF12911.7 AMD20893.1 - 0.012 15.5 0.2 0.057 13.4 0.2 2.1 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C HA2 PF04408.23 AMD20894.1 - 1.9e-20 73.1 0.0 3.9e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AMD20894.1 - 6.8e-11 42.5 0.0 1.5e-10 41.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD20894.1 - 6e-09 35.9 0.3 1.1e-08 35.1 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 AMD20894.1 - 9.1e-09 35.6 0.0 2.4e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 AMD20894.1 - 4.2e-05 23.8 0.4 0.00011 22.5 0.4 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD20894.1 - 0.0012 19.2 0.3 0.0021 18.4 0.3 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AMD20894.1 - 0.0017 18.1 0.1 0.003 17.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 AMD20894.1 - 0.0024 17.5 0.0 0.0061 16.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 AMD20894.1 - 0.0051 16.5 0.6 0.021 14.5 0.6 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_29 PF13555.6 AMD20894.1 - 0.008 15.9 0.0 0.024 14.4 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AMD20894.1 - 0.013 15.4 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Flavi_DEAD PF07652.14 AMD20894.1 - 0.016 15.2 0.2 0.18 11.8 0.1 2.2 2 0 0 2 2 2 0 Flavivirus DEAD domain ABC_tran PF00005.27 AMD20894.1 - 0.048 14.2 0.8 0.19 12.2 0.6 1.8 1 1 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 AMD20894.1 - 0.095 12.2 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Helicase_RecD PF05127.14 AMD20894.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Helicase AAA_23 PF13476.6 AMD20894.1 - 0.21 12.1 0.0 0.49 10.9 0.0 1.5 2 0 0 2 2 1 0 AAA domain SUR7 PF06687.12 AMD20895.1 - 6.4e-17 61.9 18.7 8.5e-17 61.5 18.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2198 PF09964.9 AMD20895.1 - 0.17 12.0 8.4 6.4 6.9 5.2 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) AEP1 PF17049.5 AMD20896.1 - 4.3e-66 223.6 9.1 1.6e-64 218.4 9.1 2.1 1 1 0 1 1 1 1 ATPase expression protein 1 SOP4 PF17081.5 AMD20896.1 - 0.069 12.7 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Suppressor of PMA 1-7 protein Tht1 PF04163.12 AMD20897.1 - 1.1e-36 126.8 16.5 2.6e-34 118.9 16.5 2.3 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Apolipoprotein PF01442.18 AMD20897.1 - 2.7e-08 33.9 5.2 5.4e-06 26.4 3.0 2.4 1 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain NPV_P10 PF05531.12 AMD20897.1 - 0.00078 19.9 13.1 0.047 14.2 2.1 3.2 3 0 0 3 3 2 2 Nucleopolyhedrovirus P10 protein DUF1548 PF07579.11 AMD20897.1 - 0.0057 17.0 3.4 0.021 15.2 1.5 2.4 1 1 1 2 2 2 1 Domain of Unknown Function (DUF1548) DUF3552 PF12072.8 AMD20897.1 - 0.0069 15.8 3.5 1.8 8.0 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) PhaP_Bmeg PF09602.10 AMD20897.1 - 0.007 16.3 7.7 0.43 10.5 3.4 2.4 2 0 0 2 2 2 2 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) AAA_13 PF13166.6 AMD20897.1 - 0.0088 14.7 8.5 0.16 10.6 4.7 2.1 2 0 0 2 2 2 2 AAA domain Baculo_PEP_C PF04513.12 AMD20897.1 - 0.01 15.9 17.9 0.067 13.2 3.8 3.4 2 1 1 4 4 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 AMD20897.1 - 0.019 15.2 2.6 0.019 15.2 2.6 3.8 3 1 0 3 3 2 0 Bacterial protein of unknown function (DUF948) COG2 PF06148.11 AMD20897.1 - 0.023 14.8 11.8 1.7 8.7 5.8 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 WASH_WAHD PF11945.8 AMD20897.1 - 0.028 13.9 0.2 0.028 13.9 0.2 2.4 2 0 0 2 2 2 0 WAHD domain of WASH complex DUF2960 PF11173.8 AMD20897.1 - 0.035 14.5 0.8 0.091 13.2 0.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2960) s48_45 PF07422.13 AMD20897.1 - 0.048 14.2 0.5 0.048 14.2 0.5 1.9 2 0 0 2 2 1 0 Sexual stage antigen s48/45 domain ARL2_Bind_BART PF11527.8 AMD20897.1 - 0.058 13.5 10.8 0.28 11.3 3.1 3.0 2 1 1 3 3 3 0 The ARF-like 2 binding protein BART TipAS PF07739.13 AMD20897.1 - 0.063 13.8 1.3 0.22 12.1 1.3 2.0 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain Exonuc_VII_L PF02601.15 AMD20897.1 - 0.14 11.7 4.7 1.8 8.0 4.7 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit PIN_8 PF18476.1 AMD20897.1 - 0.17 11.8 4.7 0.52 10.1 3.3 2.2 2 0 0 2 2 2 0 PIN like domain ApoLp-III PF07464.11 AMD20897.1 - 0.17 12.0 13.2 2.7 8.1 0.6 2.8 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Syntaxin_2 PF14523.6 AMD20897.1 - 0.19 12.1 9.5 45 4.5 3.4 4.1 3 1 0 3 3 3 0 Syntaxin-like protein Nup54 PF13874.6 AMD20897.1 - 0.26 11.4 3.8 1.2 9.2 1.6 2.7 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 CLZ PF16526.5 AMD20897.1 - 0.34 11.3 4.6 6.9 7.1 0.1 3.5 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CdvA PF18822.1 AMD20897.1 - 0.46 10.3 8.9 5.5 6.8 0.0 3.3 2 2 1 3 3 3 0 CdvA-like coiled-coil domain CorA PF01544.18 AMD20897.1 - 0.5 9.6 13.5 1.8 7.8 1.7 2.6 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein YtxH PF12732.7 AMD20897.1 - 0.63 10.6 8.0 4e+02 1.6 8.0 3.7 1 1 0 1 1 1 0 YtxH-like protein DUF4665 PF15679.5 AMD20897.1 - 0.67 10.6 7.4 4.8 7.9 0.5 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4665) MnmE_helical PF12631.7 AMD20897.1 - 0.77 9.9 11.6 3.2 7.9 2.4 3.4 2 1 1 4 4 3 0 MnmE helical domain CENP-F_leu_zip PF10473.9 AMD20897.1 - 0.78 9.8 7.9 18 5.3 4.4 2.7 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 AMD20897.1 - 0.93 9.5 12.7 2.4 8.2 1.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 AMD20897.1 - 0.98 9.9 5.5 12 6.4 0.7 3.2 2 2 0 2 2 2 0 Snapin/Pallidin HSCB_C PF07743.13 AMD20897.1 - 1.1 9.8 9.7 51 4.5 0.1 3.6 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain Fzo_mitofusin PF04799.13 AMD20897.1 - 1.6 8.3 5.9 5 6.7 2.0 2.5 2 0 0 2 2 2 0 fzo-like conserved region Syntaxin-6_N PF09177.11 AMD20897.1 - 2.2 8.9 10.5 7 7.3 3.6 3.4 1 1 0 2 2 2 0 Syntaxin 6, N-terminal ING PF12998.7 AMD20897.1 - 2.3 8.9 7.9 2.4 8.8 0.1 2.9 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Swi5 PF07061.11 AMD20897.1 - 2.6 8.2 6.9 2.2 8.4 0.5 3.3 2 1 1 3 3 3 0 Swi5 DUF16 PF01519.16 AMD20897.1 - 3.5 8.2 11.1 3.7 8.1 2.3 3.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 Med2 PF11214.8 AMD20897.1 - 4.7 7.4 11.8 0.073 13.2 0.6 3.2 3 1 0 3 3 3 0 Mediator complex subunit 2 Fib_alpha PF08702.10 AMD20897.1 - 5.7 7.1 15.0 3.7 7.7 0.7 3.1 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Endonuclease_NS PF01223.23 AMD20898.1 - 4.4e-67 226.2 0.0 5.2e-67 226.0 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Kinesin PF00225.23 AMD20899.1 - 2.4e-97 325.9 1.2 2.4e-97 325.9 1.2 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 AMD20899.1 - 5e-27 94.7 0.0 1.8e-26 92.9 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding Cnn_1N PF07989.11 AMD20899.1 - 0.02 15.0 11.4 0.02 15.0 11.4 3.3 3 1 0 3 3 3 0 Centrosomin N-terminal motif 1 DUF3287 PF11690.8 AMD20899.1 - 0.13 12.0 5.8 0.99 9.1 0.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3287) DUF1706 PF08020.11 AMD20899.1 - 0.18 11.7 2.8 0.36 10.7 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1706) ADIP PF11559.8 AMD20899.1 - 6.4 6.9 33.6 2.6 8.1 8.2 2.6 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding GOLGA2L5 PF15070.6 AMD20899.1 - 7.1 5.2 28.0 21 3.6 27.9 1.6 1 1 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 V-ATPase_C PF03223.15 AMD20900.1 - 1.2e-122 409.9 3.1 1.4e-122 409.7 3.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C EF1G PF00647.19 AMD20901.1 - 1.1e-45 154.0 0.2 2.3e-45 153.0 0.2 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 AMD20901.1 - 1.3e-10 41.4 0.0 1.3e-10 41.4 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AMD20901.1 - 4.7e-08 33.3 0.5 4.3e-07 30.2 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 AMD20901.1 - 0.0002 21.7 0.0 0.00058 20.2 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 AMD20901.1 - 0.068 13.4 0.0 0.068 13.4 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 AMD20901.1 - 0.068 13.2 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SURF6 PF04935.12 AMD20902.1 - 2.4e-45 154.8 43.4 2.4e-45 154.8 43.4 2.2 2 0 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.6 AMD20902.1 - 7.9e-11 42.4 1.9 7.9e-11 42.4 1.9 6.1 4 2 0 4 4 4 1 60S ribosome biogenesis protein Rrp14 EMC3_TMCO1 PF01956.16 AMD20902.1 - 3.7 7.3 0.0 3.7 7.3 0.0 3.6 3 2 0 4 4 4 0 Integral membrane protein EMC3/TMCO1-like PPR_long PF17177.4 AMD20903.1 - 0.00054 19.4 1.0 0.038 13.3 0.2 2.6 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP UBX PF00789.20 AMD20904.1 - 5.3e-10 39.4 0.5 1.2e-09 38.3 0.0 1.9 2 0 0 2 2 2 1 UBX domain TUG-UBL1 PF11470.8 AMD20904.1 - 1.3e-09 38.1 0.0 8.2e-09 35.6 0.0 2.3 2 0 0 2 2 2 1 TUG ubiquitin-like domain Ank_2 PF12796.7 AMD20905.1 - 2e-23 82.8 0.8 1.8e-09 38.1 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AMD20905.1 - 1.1e-21 76.9 12.5 7.4e-09 36.0 0.3 4.7 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 AMD20905.1 - 2e-15 56.4 6.7 0.0021 18.5 0.1 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 AMD20905.1 - 1.6e-13 49.5 5.3 0.0019 18.5 0.1 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 AMD20905.1 - 1e-10 41.6 1.1 8.5e-05 22.8 0.0 4.0 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ldh_1_C PF02866.18 AMD20906.1 - 5.3e-50 169.6 0.0 1.4e-49 168.2 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 AMD20906.1 - 6.8e-42 142.9 0.0 9.5e-42 142.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 AMD20906.1 - 0.00011 21.4 0.0 0.00014 21.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ParBc PF02195.18 AMD20907.1 - 4.1e-13 49.4 0.0 4.8e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain G-alpha PF00503.20 AMD20908.1 - 3.4e-110 368.6 0.0 4.2e-110 368.3 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 AMD20908.1 - 8.1e-15 54.7 1.2 1.4e-09 37.7 0.0 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD20908.1 - 0.0046 16.4 1.3 0.15 11.4 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MmgE_PrpD PF03972.14 AMD20908.1 - 0.0069 15.0 0.0 0.017 13.7 0.0 1.5 2 0 0 2 2 2 1 MmgE/PrpD family GTP_EFTU PF00009.27 AMD20908.1 - 0.087 12.4 0.0 0.93 9.0 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Roc PF08477.13 AMD20908.1 - 0.13 12.4 0.2 3.4 7.9 0.1 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Cyto_heme_lyase PF01265.17 AMD20909.1 - 3.6e-43 148.2 3.1 1.8e-41 142.6 3.1 2.1 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase zf-Tim10_DDP PF02953.15 AMD20910.1 - 3.1e-20 71.6 1.9 3.9e-20 71.3 1.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Flavoprotein PF02441.19 AMD20911.1 - 2e-54 183.6 0.0 2.9e-54 183.1 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein CKAP2_C PF15297.6 AMD20911.1 - 0.22 10.6 2.1 0.29 10.2 2.1 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Merozoite_SPAM PF07133.11 AMD20911.1 - 4 7.4 22.9 6.5 6.7 22.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SDA1 PF05285.12 AMD20911.1 - 5.7 6.3 22.1 8.5 5.7 22.1 1.1 1 0 0 1 1 1 0 SDA1 Ydc2-catalyt PF09159.10 AMD20913.1 - 3.1e-42 145.2 0.6 4.3e-42 144.8 0.6 1.2 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.13 AMD20913.1 - 0.016 15.4 0.3 0.54 10.4 0.1 2.8 2 1 0 2 2 2 0 Poxvirus A22 protein Crystallin PF00525.18 AMD20913.1 - 0.019 15.1 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 Alpha crystallin A chain, N terminal NAD_binding_10 PF13460.6 AMD20914.1 - 2.7e-41 141.5 0.0 3.1e-41 141.3 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 AMD20914.1 - 7e-11 42.1 0.1 3.3e-10 39.9 0.1 1.8 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 AMD20914.1 - 3.5e-08 33.2 0.0 7.3e-08 32.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 AMD20914.1 - 1.1e-05 24.6 0.1 1.9e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 AMD20914.1 - 0.0001 22.7 0.2 0.00021 21.7 0.2 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 AMD20914.1 - 0.00054 19.1 0.0 0.00091 18.4 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain DapB_N PF01113.20 AMD20914.1 - 0.00056 20.0 0.4 0.0011 19.1 0.4 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 AMD20914.1 - 0.0016 18.5 0.5 0.0036 17.4 0.5 1.6 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 AMD20914.1 - 0.0018 17.5 0.0 0.37 9.9 0.0 2.8 1 1 0 2 2 2 1 Male sterility protein Shikimate_DH PF01488.20 AMD20914.1 - 0.0052 16.9 0.1 0.011 15.8 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 AMD20914.1 - 0.054 12.6 0.1 0.63 9.1 0.1 2.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Peptidase_S24 PF00717.23 AMD20915.1 - 1.6e-08 34.3 0.1 2.8e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like FF PF01846.19 AMD20916.1 - 5.5e-35 119.3 16.8 3.1e-12 46.5 0.3 5.3 5 0 0 5 5 5 4 FF domain WW PF00397.26 AMD20916.1 - 1.3e-19 70.0 17.9 9.6e-12 44.8 1.1 3.4 3 0 0 3 3 3 2 WW domain Glyco_hyd_101C PF17451.2 AMD20916.1 - 0.00011 22.5 4.9 0.01 16.1 0.4 2.9 1 1 1 2 2 2 2 Glycosyl hydrolase 101 beta sandwich domain RhoGAP-FF1 PF16512.5 AMD20916.1 - 0.019 15.6 12.7 0.041 14.5 3.7 3.6 4 0 0 4 4 4 0 p190-A and -B Rho GAPs FF domain ARPC4 PF05856.12 AMD20917.1 - 1.8e-70 235.9 6.7 2e-70 235.7 6.7 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Fungal_trans PF04082.18 AMD20918.1 - 4.7e-21 75.0 0.5 9.5e-21 74.0 0.5 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD20918.1 - 3.4e-06 27.1 7.7 7.4e-06 26.0 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5321 PF17254.2 AMD20919.1 - 9.5e-07 28.4 3.3 2.1e-06 27.3 1.6 2.1 1 1 1 2 2 2 1 Family of unknown function (DUF5321) DUF4974 PF16344.5 AMD20919.1 - 0.0044 17.0 0.2 0.27 11.2 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4974) SLATT_6 PF18169.1 AMD20919.1 - 0.098 12.2 1.8 0.29 10.7 0.2 2.0 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 COX16 PF14138.6 AMD20919.1 - 0.22 12.0 1.9 0.26 11.8 0.2 2.2 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Npa1 PF11707.8 AMD20920.1 - 2.4e-94 316.5 1.6 2.4e-94 316.5 1.6 1.8 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 AMD20920.1 - 1e-45 155.8 2.9 1e-45 155.8 2.9 2.5 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 Fungal_trans PF04082.18 AMD20921.1 - 1.2e-16 60.6 0.2 1.8e-16 60.0 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD20921.1 - 3e-09 36.8 6.7 7.9e-09 35.5 6.7 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sipho_Gp157 PF05565.11 AMD20921.1 - 0.002 18.1 0.2 0.0046 17.0 0.2 1.5 1 0 0 1 1 1 1 Siphovirus Gp157 Mt_ATP-synt_D PF05873.12 AMD20922.1 - 8.8e-17 61.4 5.6 1.2e-16 61.0 5.6 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Dor1 PF04124.12 AMD20922.1 - 0.002 16.9 2.8 0.0024 16.6 2.8 1.1 1 0 0 1 1 1 1 Dor1-like family DUF4201 PF13870.6 AMD20922.1 - 0.004 16.9 2.0 0.018 14.7 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Luteo_P1-P2 PF08467.10 AMD20922.1 - 0.0049 16.2 0.1 0.0065 15.8 0.1 1.2 1 0 0 1 1 1 1 Luteovirus RNA polymerase P1-P2/replicase Spc7 PF08317.11 AMD20922.1 - 0.098 11.5 6.2 0.028 13.3 3.1 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 AMD20922.1 - 0.17 11.9 2.4 1.5 8.8 2.4 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2408 PF10303.9 AMD20922.1 - 0.2 12.2 4.0 0.79 10.3 3.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) IZUMO PF15005.6 AMD20922.1 - 0.2 12.2 0.9 0.24 11.9 0.2 1.5 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated LTXXQ PF07813.12 AMD20922.1 - 0.2 12.4 4.7 2.3 9.0 1.0 2.1 2 0 0 2 2 2 0 LTXXQ motif family protein DUF5339 PF17274.2 AMD20922.1 - 0.43 11.5 0.1 0.43 11.5 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5339) DUF16 PF01519.16 AMD20922.1 - 0.72 10.4 4.2 1.8 9.1 4.2 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 AAA_12 PF13087.6 AMD20923.1 - 4.7e-59 199.4 0.1 9.6e-59 198.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AMD20923.1 - 1e-55 189.3 0.4 2.6e-55 188.0 0.4 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD20923.1 - 7.2e-13 49.1 0.0 3.8e-12 46.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AMD20923.1 - 2.2e-11 43.9 0.0 6.8e-10 39.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 AMD20923.1 - 9.4e-07 28.8 0.1 0.54 10.0 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 AMD20923.1 - 9.8e-07 28.6 0.2 0.0011 18.6 0.1 2.4 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain DEAD PF00270.29 AMD20923.1 - 1.5e-05 24.8 0.5 0.00037 20.3 0.5 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 AMD20923.1 - 1.8e-05 24.8 0.0 8.9e-05 22.6 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 AMD20923.1 - 0.00022 20.8 0.0 0.012 15.0 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein Helicase_RecD PF05127.14 AMD20923.1 - 0.00053 19.9 0.0 0.0069 16.3 0.0 2.7 3 0 0 3 3 3 1 Helicase T2SSE PF00437.20 AMD20923.1 - 0.0014 17.8 0.0 0.0028 16.7 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 AMD20923.1 - 0.0024 18.2 0.1 0.0091 16.3 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 AMD20923.1 - 0.0037 17.7 1.2 0.25 11.8 0.0 3.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 AMD20923.1 - 0.021 13.8 0.0 0.043 12.7 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Rad17 PF03215.15 AMD20923.1 - 0.026 14.5 1.2 5.5 6.9 0.0 2.9 2 1 1 3 3 2 0 Rad17 P-loop domain AAA_16 PF13191.6 AMD20923.1 - 0.037 14.4 0.0 0.099 13.0 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 AMD20923.1 - 0.038 14.0 0.2 4.3 7.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 AMD20923.1 - 0.064 13.0 0.0 0.24 11.1 0.0 2.0 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 AMD20923.1 - 0.083 12.9 0.0 0.29 11.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AMD20923.1 - 0.085 13.4 0.1 1.2 9.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain Flavi_DEAD PF07652.14 AMD20923.1 - 0.091 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_33 PF13671.6 AMD20923.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AMD20923.1 - 0.46 11.0 9.3 2.3 8.7 0.0 3.6 3 1 1 4 4 4 0 AAA domain AAA_24 PF13479.6 AMD20923.1 - 0.52 10.0 5.8 0.55 9.9 1.8 3.0 2 1 0 2 2 2 0 AAA domain UvrD_C PF13361.6 AMD20923.1 - 3.2 7.0 10.9 4.4e+02 0.0 10.4 3.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain WD40 PF00400.32 AMD20924.1 - 1.8e-13 50.7 0.3 0.002 18.9 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20924.1 - 6.4e-07 29.6 0.0 0.46 10.8 0.0 4.3 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 AMD20924.1 - 0.002 16.7 0.0 0.1 11.1 0.0 2.4 2 1 0 2 2 2 2 Cytochrome D1 heme domain Lactonase PF10282.9 AMD20924.1 - 0.1 11.8 0.0 4.2 6.5 0.0 2.8 2 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Frtz PF11768.8 AMD20924.1 - 0.19 10.0 0.0 0.8 8.0 0.0 1.8 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF1748 PF08520.10 AMD20925.1 - 4.4e-24 84.2 0.1 5.4e-24 83.9 0.1 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) IRK_C PF17655.1 AMD20925.1 - 0.15 11.7 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Inward rectifier potassium channel C-terminal domain Apc15p PF05841.11 AMD20926.1 - 6.5e-17 62.5 1.2 2.4e-16 60.7 0.0 2.2 1 1 1 2 2 2 1 Apc15p protein DUF4667 PF15700.5 AMD20926.1 - 0.0087 16.2 2.9 0.01 16.0 2.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) DSPc PF00782.20 AMD20927.1 - 1.6e-25 89.5 2.2 1.6e-24 86.2 0.7 2.6 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AMD20927.1 - 0.0013 18.3 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase HECT_2 PF09814.9 AMD20927.1 - 0.0042 16.0 1.9 0.03 13.2 0.1 2.1 2 0 0 2 2 2 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Elf1 PF05129.13 AMD20927.1 - 0.016 15.2 0.4 1.9 8.6 0.0 2.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Yippee-Mis18 PF03226.14 AMD20927.1 - 0.026 14.8 1.5 0.13 12.4 1.5 2.2 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PTPlike_phytase PF14566.6 AMD20927.1 - 0.07 13.2 0.0 0.77 9.9 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate RIG-I_C-RD PF11648.8 AMD20927.1 - 0.097 12.9 1.1 2 8.6 0.0 2.4 2 0 0 2 2 2 0 C-terminal domain of RIG-I zinc_ribbon_4 PF13717.6 AMD20927.1 - 0.2 11.6 2.5 4.7 7.2 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 AMD20927.1 - 0.61 10.0 0.1 0.61 10.0 0.1 2.8 3 0 0 3 3 3 0 SprT-like zinc ribbon domain PPTA PF01239.22 AMD20928.1 - 4.3e-34 115.2 19.9 2.8e-08 33.2 0.4 5.8 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat LHH PF14411.6 AMD20928.1 - 2.8e-05 24.2 0.3 7e-05 22.9 0.3 1.7 1 0 0 1 1 1 1 A nuclease of the HNH/ENDO VII superfamily with conserved LHH Ank_2 PF12796.7 AMD20929.1 - 4.2e-10 40.1 0.1 1.2e-09 38.6 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) TIG PF01833.24 AMD20929.1 - 3.7e-09 36.5 0.2 9.9e-08 32.0 0.2 2.5 2 0 0 2 2 2 1 IPT/TIG domain Ank_4 PF13637.6 AMD20929.1 - 1.4e-08 35.1 0.2 5.1e-08 33.3 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 AMD20929.1 - 1.8e-08 34.5 0.3 0.00068 20.0 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 AMD20929.1 - 5.3e-07 29.5 0.1 0.0011 19.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 AMD20929.1 - 1.3e-05 25.3 0.0 0.0067 16.7 0.0 2.8 1 1 0 2 2 2 1 Ankyrin repeats (many copies) P53 PF00870.18 AMD20929.1 - 0.00011 22.0 0.7 0.00022 21.1 0.7 1.4 1 0 0 1 1 1 1 P53 DNA-binding domain RHD_dimer PF16179.5 AMD20929.1 - 0.0051 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain WD40 PF00400.32 AMD20930.1 - 3.3e-22 78.3 4.8 4.9e-07 30.3 0.3 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD20930.1 - 3e-09 37.0 1.1 0.099 13.0 0.2 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD20930.1 - 1.4e-05 24.0 2.0 0.085 11.5 0.0 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 AMD20930.1 - 4.2e-05 22.5 3.7 0.33 9.6 0.1 4.2 2 2 2 4 4 4 3 Nup133 N terminal like BBS2_Mid PF14783.6 AMD20930.1 - 0.019 15.0 1.8 8.8 6.4 0.0 3.9 5 0 0 5 5 5 0 Ciliary BBSome complex subunit 2, middle region SpmSyn_N PF17950.1 AMD20930.1 - 0.11 12.8 0.0 5.6 7.2 0.0 2.6 2 0 0 2 2 2 0 S-adenosylmethionine decarboxylase N -terminal AlaDh_PNT_N PF05222.15 AMD20931.1 - 4.3e-29 101.5 0.0 6.7e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 AMD20931.1 - 0.00032 20.1 0.0 0.00068 19.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TPR_1 PF00515.28 AMD20932.1 - 1.1e-37 126.3 11.6 3.1e-06 26.8 0.0 10.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 AMD20932.1 - 1.6e-34 115.2 7.3 0.00038 20.4 0.0 10.1 10 0 0 10 10 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD20932.1 - 1.7e-31 108.3 14.3 1.9e-25 88.9 0.1 5.0 4 2 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AMD20932.1 - 2.4e-23 80.3 7.6 0.0077 16.4 0.0 9.0 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 AMD20932.1 - 7.7e-22 77.4 5.9 4.1e-07 30.2 0.0 8.8 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 AMD20932.1 - 4.7e-18 65.5 0.4 0.0008 19.9 0.0 7.3 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 AMD20932.1 - 2.6e-16 58.7 7.2 0.0051 17.1 0.0 9.1 9 1 1 10 10 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 AMD20932.1 - 6.1e-15 54.6 1.1 0.073 12.8 0.0 7.4 5 2 2 7 7 7 4 TPR repeat TPR_7 PF13176.6 AMD20932.1 - 9.2e-14 50.4 1.7 0.0038 17.2 0.0 7.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 AMD20932.1 - 1.1e-12 47.6 0.1 0.2 12.6 0.0 7.4 4 2 4 8 8 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 AMD20932.1 - 8.5e-12 44.5 1.4 0.023 14.5 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 AMD20932.1 - 1.2e-11 45.1 0.0 0.033 14.8 0.0 5.6 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 AMD20932.1 - 2e-09 37.5 12.3 1.2 10.0 0.2 8.6 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 AMD20932.1 - 4.5e-06 26.1 0.1 0.56 9.4 0.0 4.9 2 2 2 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 AMD20932.1 - 2e-05 24.5 4.2 0.37 10.9 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 AMD20932.1 - 2.3e-05 24.4 0.1 0.14 12.3 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AMD20932.1 - 0.0001 22.3 7.3 5 7.3 0.0 5.8 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat SRP_TPR_like PF17004.5 AMD20932.1 - 0.00014 21.9 5.1 0.31 11.1 0.1 4.4 2 1 2 4 4 4 2 Putative TPR-like repeat ChAPs PF09295.10 AMD20932.1 - 0.0002 20.5 0.9 0.092 11.7 0.1 3.5 2 1 2 4 4 4 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_MalT PF17874.1 AMD20932.1 - 0.00071 19.0 1.6 1.5 8.2 0.0 4.0 5 0 0 5 5 5 1 MalT-like TPR region DUF3808 PF10300.9 AMD20932.1 - 0.013 14.3 2.1 2.3 6.8 0.1 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3808) TPR_20 PF14561.6 AMD20932.1 - 0.023 15.0 0.1 4.3 7.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 AMD20932.1 - 0.052 13.3 1.0 8.6 6.0 0.0 4.1 2 2 2 4 4 4 0 Tetratricopeptide repeat-like domain Sel1 PF08238.12 AMD20932.1 - 0.66 10.7 3.7 32 5.4 0.0 3.9 3 0 0 3 3 2 0 Sel1 repeat ADK PF00406.22 AMD20933.1 - 9.7e-45 152.4 0.0 1.3e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AMD20933.1 - 2.6e-37 128.3 0.4 4.1e-37 127.6 0.1 1.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AMD20933.1 - 1.2e-10 42.0 0.0 1.9e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AMD20933.1 - 1.3e-07 31.9 0.0 2.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AMD20933.1 - 1.4e-05 24.4 0.0 2.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.17 AMD20933.1 - 9.5e-05 22.1 0.3 0.25 11.0 0.1 2.2 2 0 0 2 2 2 2 Thymidylate kinase AAA_19 PF13245.6 AMD20933.1 - 0.12 12.7 0.1 0.25 11.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 AMD20933.1 - 0.13 12.1 0.1 0.61 9.9 0.0 2.0 2 0 0 2 2 2 0 Deoxynucleoside kinase adh_short PF00106.25 AMD20934.1 - 1.5e-43 148.5 0.2 1.8e-43 148.3 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AMD20934.1 - 1.5e-29 103.2 0.1 1.9e-29 102.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD20934.1 - 7.8e-11 42.2 0.1 1.2e-10 41.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AMD20934.1 - 0.011 15.2 0.0 0.046 13.2 0.0 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Pan3_PK PF18101.1 AMD20935.1 - 1.3e-53 180.7 0.2 1.9e-53 180.2 0.2 1.2 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 AMD20935.1 - 2.8e-06 26.9 0.1 6.3e-06 25.7 0.1 1.5 1 1 1 2 2 2 1 Protein kinase domain DUF1386 PF07138.11 AMD20935.1 - 0.19 10.9 5.1 1.1 8.4 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1386) DUF5341 PF17276.2 AMD20936.1 - 2.4e-05 24.6 0.0 2.5e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5341) AA_permease_2 PF13520.6 AMD20937.1 - 3.1e-76 256.9 48.2 3.7e-76 256.7 48.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AMD20937.1 - 6e-19 68.0 37.1 6e-19 68.0 37.1 1.9 1 1 0 2 2 2 2 Amino acid permease SUI1 PF01253.22 AMD20938.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AMD20938.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Homeodomain PF00046.29 AMD20939.1 - 1.5e-15 56.8 2.0 1.8e-15 56.5 2.0 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AMD20939.1 - 6.7e-06 25.9 0.3 6.7e-06 25.9 0.3 2.0 2 1 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 AMD20939.1 - 0.033 14.1 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT WD40 PF00400.32 AMD20942.1 - 0.027 15.3 0.2 3.5 8.7 0.0 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat SLD5_C PF16922.5 AMD20943.1 - 2.8e-18 65.8 0.1 5.4e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 AMD20943.1 - 2.2e-08 34.5 1.2 8.6e-08 32.6 1.2 1.9 1 1 0 1 1 1 1 GINS complex protein Peptidase_M16_C PF05193.21 AMD20944.1 - 1e-19 71.2 0.2 1.6e-18 67.4 0.0 3.0 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AMD20944.1 - 5e-11 42.8 0.0 2e-10 40.8 0.0 2.0 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) ACP_PD PF04336.12 AMD20944.1 - 0.027 14.9 0.4 0.16 12.4 0.2 2.4 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase DUF1949 PF09186.11 AMD20944.1 - 0.078 12.9 0.0 16 5.5 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1949) Pkinase PF00069.25 AMD20945.1 - 1.3e-63 214.9 0.1 2.3e-63 214.0 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD20945.1 - 1.2e-32 113.2 0.0 2.2e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD20945.1 - 6.2e-09 35.6 0.0 1.1e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AMD20945.1 - 6.1e-07 29.0 0.1 1.5e-06 27.7 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AMD20945.1 - 4.3e-05 22.6 1.0 4.3e-05 22.6 1.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 AMD20945.1 - 0.00013 21.7 0.4 0.05 13.2 0.0 2.5 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AMD20945.1 - 0.00014 20.8 0.1 0.00014 20.8 0.1 3.0 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 AMD20945.1 - 0.033 14.1 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 AMD20945.1 - 0.15 11.7 0.9 0.31 10.6 0.1 1.9 2 0 0 2 2 2 0 RIO1 family DUF1493 PF07377.12 AMD20946.1 - 0.01 16.3 0.4 0.074 13.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1493) HlyIII PF03006.20 AMD20947.1 - 9.3e-55 185.8 23.3 1.1e-54 185.5 23.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related ODC_AZ PF02100.17 AMD20947.1 - 0.13 12.2 0.0 2 8.4 0.0 2.2 2 0 0 2 2 2 0 Ornithine decarboxylase antizyme PTS_2-RNA PF01885.16 AMD20949.1 - 2.3e-52 177.7 2.9 3.4e-52 177.1 2.9 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family La PF05383.17 AMD20949.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 La domain CNH PF00780.22 AMD20951.1 - 0.00027 20.6 0.7 0.0017 18.0 0.7 2.3 1 1 0 1 1 1 1 CNH domain CPL PF08144.11 AMD20952.1 - 1.4e-49 168.1 2.9 1.1e-43 149.0 0.0 5.6 5 1 0 5 5 5 2 CPL (NUC119) domain PUF PF00806.19 AMD20952.1 - 4e-07 29.4 3.7 0.27 11.0 0.0 5.8 6 0 0 6 6 6 3 Pumilio-family RNA binding repeat YL1 PF05764.13 AMD20952.1 - 0.012 15.7 11.2 0.031 14.4 11.2 1.7 1 0 0 1 1 1 0 YL1 nuclear protein HNOB PF07700.15 AMD20952.1 - 0.073 13.0 0.0 0.46 10.4 0.0 2.4 2 0 0 2 2 2 0 Haem-NO-binding SAC3 PF12209.8 AMD20952.1 - 0.078 13.2 5.1 5.6 7.2 0.0 4.5 3 2 1 4 4 4 0 Leucine permease transcriptional regulator helical domain RRN3 PF05327.11 AMD20952.1 - 0.65 8.5 7.8 1.8 7.0 7.8 1.8 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cwf_Cwc_15 PF04889.12 AMD20952.1 - 3.7 7.2 19.9 10 5.8 19.9 1.7 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 AMD20952.1 - 6.9 6.0 22.8 13 5.1 22.8 1.4 1 0 0 1 1 1 0 SDA1 Sugar_tr PF00083.24 AMD20953.1 - 4.2e-126 421.4 28.3 5.1e-126 421.2 28.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD20953.1 - 2.3e-32 112.3 34.5 2.3e-30 105.7 25.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 AMD20953.1 - 4.2e-07 28.8 4.8 7.1e-07 28.0 4.8 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 AMD20953.1 - 0.00051 18.6 1.2 0.00051 18.6 1.2 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector Sec20 PF03908.13 AMD20954.1 - 3.6e-22 78.1 2.1 1e-21 76.6 2.1 1.8 1 0 0 1 1 1 1 Sec20 Synaptobrevin PF00957.21 AMD20954.1 - 0.22 11.3 2.0 0.21 11.4 0.6 1.8 2 0 0 2 2 2 0 Synaptobrevin Utp12 PF04003.12 AMD20955.1 - 0.00048 20.4 1.1 0.0011 19.3 1.1 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family DUF678 PF05077.12 AMD20955.1 - 0.015 15.4 1.5 11 6.3 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF678) DUF866 PF05907.13 AMD20955.1 - 0.029 14.3 0.6 0.26 11.2 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF866) Pribosyltran PF00156.27 AMD20956.1 - 2.7e-10 40.0 0.0 3.7e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain vWA-TerF-like PF10138.9 AMD20956.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.6 1 1 0 1 1 1 0 vWA found in TerF C terminus Chitin_synth_1 PF01644.17 AMD20956.1 - 0.1 12.6 0.2 15 5.5 0.0 2.1 2 0 0 2 2 2 0 Chitin synthase TMF_TATA_bd PF12325.8 AMD20957.1 - 4.8e-26 91.2 19.4 4.8e-26 91.2 19.4 6.0 2 1 4 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 AMD20957.1 - 7.5e-11 41.9 14.4 7.5e-11 41.9 14.4 8.7 2 2 6 9 9 8 2 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 AMD20957.1 - 0.00054 18.9 27.1 0.00054 18.9 27.1 3.6 3 1 0 4 4 4 1 Spc7 kinetochore protein DUF812 PF05667.11 AMD20957.1 - 0.0015 17.5 25.1 0.0015 17.5 25.1 3.7 1 1 2 3 3 3 2 Protein of unknown function (DUF812) Tropomyosin PF00261.20 AMD20957.1 - 0.0061 15.9 16.1 0.0061 15.9 16.1 3.9 2 1 2 4 4 3 1 Tropomyosin DUF1664 PF07889.12 AMD20957.1 - 0.023 14.7 39.0 0.38 10.8 6.9 6.0 4 3 2 6 6 6 0 Protein of unknown function (DUF1664) DUF3584 PF12128.8 AMD20957.1 - 0.078 10.5 58.0 0.025 12.1 40.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) HSBP1 PF06825.12 AMD20957.1 - 0.29 11.0 7.6 3.9 7.4 0.4 3.9 3 0 0 3 3 3 0 Heat shock factor binding protein 1 IFT57 PF10498.9 AMD20957.1 - 0.54 9.2 60.7 0.053 12.5 15.5 4.9 2 2 1 4 4 4 0 Intra-flagellar transport protein 57 DUF745 PF05335.13 AMD20957.1 - 1.1 8.9 37.6 0.13 12.0 9.7 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF745) DUF948 PF06103.11 AMD20957.1 - 1.3 9.4 18.8 1.3 9.3 1.0 4.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) TACC_C PF05010.14 AMD20957.1 - 6.1 6.6 64.9 1.1 9.0 24.9 3.2 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal RIX1 PF08167.12 AMD20958.1 - 1.7e-48 164.9 2.1 1.7e-48 164.9 2.1 1.9 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis ACP53EA PF06313.11 AMD20958.1 - 0.073 13.3 0.1 0.22 11.7 0.1 1.8 1 0 0 1 1 1 0 Drosophila ACP53EA protein DUF1512 PF07431.12 AMD20959.1 - 0.019 14.0 0.3 0.027 13.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) Phage_GP20 PF06810.11 AMD20959.1 - 0.41 10.4 6.7 0.34 10.7 0.5 2.6 2 1 1 3 3 3 0 Phage minor structural protein GP20 7TMR-HDED PF07697.11 AMD20959.1 - 0.58 10.2 5.2 0.32 11.1 1.9 1.5 1 1 1 2 2 2 0 7TM-HD extracellular zf-Tim10_DDP PF02953.15 AMD20960.1 - 7.3e-20 70.4 2.4 9.4e-20 70.0 2.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Tti2 PF10521.9 AMD20961.1 - 3.7e-52 177.6 1.4 4.6e-52 177.3 1.4 1.1 1 0 0 1 1 1 1 Tti2 family DUF4513 PF14983.6 AMD20961.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4513) Chalcone_2 PF16035.5 AMD20962.1 - 1.1e-61 208.2 0.0 1.4e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 AMD20962.1 - 0.024 14.8 0.2 0.11 12.6 0.2 2.0 1 1 1 2 2 2 0 Chalcone isomerase-like NIR_SIR PF01077.22 AMD20963.1 - 4.1e-50 169.4 0.0 5.1e-47 159.3 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 AMD20963.1 - 4.1e-26 90.6 0.1 1.2e-12 47.5 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 AMD20963.1 - 4.5e-26 91.8 0.0 9.4e-26 90.7 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin VWA_2 PF13519.6 AMD20964.1 - 2.2e-19 70.1 0.2 1.6e-18 67.3 0.0 2.3 3 1 1 4 4 4 1 von Willebrand factor type A domain Ssl1 PF04056.14 AMD20964.1 - 3.1e-05 23.9 0.1 4.5e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 AMD20964.1 - 0.00039 20.7 0.6 0.00056 20.2 0.6 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain IML1 PF12257.8 AMD20965.1 - 1.3e-100 336.2 0.1 1.9e-100 335.7 0.1 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 AMD20965.1 - 1.2e-23 83.0 0.2 2.8e-23 81.8 0.2 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Homoserine_dh PF00742.19 AMD20966.1 - 5.4e-51 173.0 0.0 6.9e-51 172.6 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 AMD20966.1 - 6.8e-20 71.9 0.0 1.2e-19 71.1 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AMD20966.1 - 0.0012 19.4 0.0 0.0032 18.0 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 AMD20966.1 - 0.0045 17.4 0.0 0.014 15.8 0.0 1.8 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 AMD20966.1 - 0.12 12.6 0.0 1.4 9.2 0.0 2.5 3 0 0 3 3 3 0 TrkA-N domain Lum_binding PF00677.17 AMD20967.1 - 0.04 13.9 0.0 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 Lumazine binding domain HECT_2 PF09814.9 AMD20968.1 - 4.3e-66 223.3 0.1 4.9e-66 223.1 0.1 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DHHA2 PF02833.14 AMD20969.1 - 3.5e-22 79.1 0.1 5.7e-22 78.5 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 AMD20969.1 - 7.8e-09 35.7 0.0 1.4e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 DHH family DUF4743 PF15916.5 AMD20970.1 - 6.7e-11 42.2 0.0 1.1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 AMD20970.1 - 2.1e-07 31.1 0.0 1.3e-06 28.5 0.0 2.0 2 0 0 2 2 2 1 NUDIX domain PMT PF02366.18 AMD20971.1 - 5.3e-82 275.1 20.8 5.3e-82 275.1 20.8 1.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AMD20971.1 - 7.4e-56 188.9 9.3 7.4e-56 188.9 9.3 3.7 3 1 0 3 3 3 2 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AMD20971.1 - 4.4e-27 95.1 0.4 2.8e-26 92.5 0.2 2.0 2 0 0 2 2 2 1 MIR domain Abhydrolase_9_N PF15420.6 AMD20971.1 - 0.059 13.4 0.4 0.23 11.5 0.1 2.0 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Mgm101p PF06420.12 AMD20972.1 - 6.5e-85 282.9 0.0 8.4e-85 282.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 tRNA-synt_2b PF00587.25 AMD20974.1 - 9.2e-34 117.0 0.3 1.8e-33 116.0 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AMD20974.1 - 2.3e-23 82.5 10.9 2.3e-23 82.5 10.9 2.0 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 AMD20974.1 - 0.025 13.2 4.7 0.038 12.6 4.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A CENP-H PF05837.12 AMD20974.1 - 0.56 10.6 6.9 0.21 12.0 4.3 1.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) NTS_2 PF15448.6 AMD20975.1 - 0.28 11.6 4.5 0.54 10.7 0.2 2.9 3 0 0 3 3 3 0 N-terminal segments of P. falciparum erythrocyte membrane protein Ribosomal_S17_N PF16205.5 AMD20976.1 - 4.9e-32 110.1 0.7 8.4e-32 109.4 0.7 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 AMD20976.1 - 3.3e-28 97.6 1.7 7.4e-28 96.5 1.7 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 Imm39 PF15568.6 AMD20976.1 - 0.079 13.1 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 39 Myb_DNA-binding PF00249.31 AMD20977.1 - 4.2e-21 74.9 23.8 2.1e-11 43.8 1.0 5.7 4 2 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD20977.1 - 1.3e-18 67.0 16.0 3e-14 53.0 2.0 4.1 3 1 1 4 4 4 2 Myb-like DNA-binding domain DUF1376 PF07120.11 AMD20977.1 - 0.044 14.1 0.4 0.18 12.1 0.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1376) Rap1_C PF11626.8 AMD20977.1 - 0.41 10.8 2.3 0.43 10.7 0.2 2.2 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MADF_DNA_bdg PF10545.9 AMD20977.1 - 0.51 10.7 11.7 14 6.1 0.4 4.4 2 2 2 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 AMD20977.1 - 1.9 9.0 14.0 0.79 10.1 1.2 4.6 4 1 1 5 5 5 0 Myb/SANT-like DNA-binding domain Vps54 PF07928.12 AMD20978.1 - 0.0012 19.2 1.1 0.0012 19.2 1.1 3.8 3 1 0 3 3 3 1 Vps54-like protein PP1_inhibitor PF05361.12 AMD20978.1 - 0.012 15.6 0.9 0.043 13.8 0.0 2.4 2 0 0 2 2 2 0 PKC-activated protein phosphatase-1 inhibitor AbiJ_NTD4 PF18863.1 AMD20978.1 - 1.1 9.7 5.4 0.9 10.0 0.2 2.7 2 1 0 2 2 2 0 AbiJ N-terminal domain 4 CENP-R PF06729.12 AMD20978.1 - 2.7 7.9 8.0 0.35 10.8 2.7 2.1 2 0 0 2 2 2 0 Kinetochore component, CENP-R Pex2_Pex12 PF04757.14 AMD20979.1 - 3.7e-18 65.9 10.6 1.1e-17 64.4 10.6 1.7 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region DUF2593 PF10767.9 AMD20979.1 - 0.03 14.4 0.3 0.051 13.6 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2593) zinc_ribbon_2 PF13240.6 AMD20979.1 - 0.11 12.3 0.0 0.11 12.3 0.0 2.3 3 0 0 3 3 3 0 zinc-ribbon domain DUF1752 PF08550.10 AMD20980.1 - 7.3e-12 44.9 2.2 7.3e-12 44.9 2.2 2.5 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) DUF5428 PF17493.2 AMD20980.1 - 0.46 10.9 0.0 0.46 10.9 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5428) WD40 PF00400.32 AMD20981.1 - 3.3e-08 34.1 3.9 0.034 15.0 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat CX9C PF16860.5 AMD20982.1 - 3.3e-26 91.0 15.5 1.1e-16 60.6 6.6 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 AMD20982.1 - 1.6e-07 31.2 15.2 0.0006 19.9 4.1 2.4 2 0 0 2 2 2 2 CHCH domain COX6B PF02297.17 AMD20982.1 - 6.6e-05 23.1 10.7 0.008 16.4 1.5 2.1 1 1 1 2 2 2 2 Cytochrome oxidase c subunit VIb Cmc1 PF08583.10 AMD20982.1 - 0.00052 20.0 13.4 0.058 13.4 1.9 3.0 1 1 2 3 3 3 3 Cytochrome c oxidase biogenesis protein Cmc1 like UPF0203 PF05254.12 AMD20982.1 - 0.0023 18.1 9.2 0.024 14.9 2.4 3.5 1 1 2 3 3 3 1 Uncharacterised protein family (UPF0203) DB PF01682.19 AMD20982.1 - 0.0055 17.0 12.5 0.1 12.9 12.5 2.2 1 1 0 1 1 1 1 DB module NDUF_B7 PF05676.13 AMD20982.1 - 0.054 13.2 8.2 0.68 9.7 0.2 2.9 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GCK PF07802.11 AMD20982.1 - 0.11 13.0 9.7 0.72 10.3 1.3 2.2 1 1 1 2 2 2 0 GCK domain ALMT PF11744.8 AMD20982.1 - 0.24 10.2 1.4 0.8 8.5 1.3 1.7 1 1 1 2 2 2 0 Aluminium activated malate transporter MTCP1 PF08991.10 AMD20982.1 - 0.31 11.3 11.5 0.79 10.0 1.9 2.5 1 1 1 2 2 2 0 Mature-T-Cell Proliferation I type SGL PF08450.12 AMD20983.1 - 4.8e-60 203.2 0.0 6e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 AMD20983.1 - 1.4e-05 25.2 0.4 0.15 12.3 0.0 3.9 4 0 0 4 4 4 2 Arylesterase TPR_14 PF13428.6 AMD20985.1 - 4.9e-28 95.4 4.4 3.7e-05 24.2 0.0 9.7 8 1 1 9 9 9 6 Tetratricopeptide repeat PRP1_N PF06424.12 AMD20985.1 - 3e-26 92.6 7.9 5.4e-16 59.3 2.0 2.7 1 1 1 2 2 2 2 PRP1 splicing factor, N-terminal TPR_19 PF14559.6 AMD20985.1 - 1.2e-15 57.8 3.1 4.3e-05 23.9 0.0 7.1 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 AMD20985.1 - 5.2e-09 35.5 0.1 0.02 15.0 0.0 6.9 6 0 0 6 6 6 1 Tetratricopeptide repeat Suf PF05843.14 AMD20985.1 - 1.2e-06 28.7 4.2 0.062 13.3 0.2 4.5 3 2 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_17 PF13431.6 AMD20985.1 - 3.6e-06 27.0 1.0 10 6.7 0.0 6.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_15 PF13429.6 AMD20985.1 - 3.6e-06 26.4 19.4 0.039 13.2 0.1 5.8 3 1 4 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 AMD20985.1 - 5.2e-06 26.8 0.1 0.66 10.7 0.1 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 AMD20985.1 - 6.8e-06 26.6 0.0 1.8 9.3 0.0 5.5 5 1 2 7 7 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 AMD20985.1 - 2.1e-05 24.1 0.0 0.097 12.4 0.0 4.8 5 0 0 5 5 5 1 TPR repeat TPR_8 PF13181.6 AMD20985.1 - 5.4e-05 23.1 0.1 0.2 12.0 0.2 4.6 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD20985.1 - 0.00028 21.1 3.6 0.4 10.9 0.5 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 AMD20985.1 - 0.00037 20.7 1.8 2.9 8.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 AMD20985.1 - 0.00042 20.4 0.8 4.4 7.5 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 AMD20985.1 - 0.0066 16.2 0.0 0.076 12.9 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat AAA_31 PF13614.6 AMD20985.1 - 0.31 10.9 2.1 2.1 8.2 0.1 2.7 3 0 0 3 3 3 0 AAA domain FAT PF02259.23 AMD20985.1 - 0.83 8.8 20.9 0.016 14.4 4.1 3.8 2 2 1 3 3 3 0 FAT domain CRAL_TRIO_N PF03765.15 AMD20985.1 - 1.3 9.2 5.9 60 3.9 0.0 4.4 4 0 0 4 4 4 0 CRAL/TRIO, N-terminal domain Cellulase PF00150.18 AMD20986.1 - 4.2e-08 33.0 0.9 4.2e-08 33.0 0.9 1.6 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DAHP_synth_1 PF00793.20 AMD20987.1 - 7.5e-100 333.3 0.0 9.3e-100 333.0 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Wtap PF17098.5 AMD20988.1 - 2.8e-08 33.9 17.1 2.8e-08 33.9 17.1 1.8 2 0 0 2 2 2 1 WTAP/Mum2p family SelP_N PF04592.14 AMD20988.1 - 0.41 10.0 12.2 1.3 8.4 12.2 1.8 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Aminotran_1_2 PF00155.21 AMD20989.1 - 3.2e-74 250.3 0.0 3.9e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AMD20989.1 - 2.5e-06 26.3 0.0 4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 AMD20989.1 - 2.5e-05 23.7 0.2 6.2e-05 22.4 0.2 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 AMD20989.1 - 0.0004 19.4 0.1 0.0011 18.0 0.1 1.6 2 0 0 2 2 2 1 Aminotransferase class-V HEPN_AbiU2 PF18734.1 AMD20989.1 - 0.011 15.2 0.2 0.028 13.9 0.2 1.6 1 0 0 1 1 1 0 AbiU2 Preseq_ALAS PF09029.10 AMD20989.1 - 0.03 14.8 0.1 0.072 13.6 0.1 1.6 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence Reticulon PF02453.17 AMD20990.1 - 6.3e-33 114.0 0.5 9.1e-33 113.4 0.5 1.2 1 0 0 1 1 1 1 Reticulon Aconitase PF00330.20 AMD20991.1 - 5e-111 371.9 0.0 5.5e-110 368.5 0.0 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AMD20991.1 - 3.9e-29 101.6 0.0 7e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain VitD-bind_III PF09164.10 AMD20991.1 - 0.15 12.0 0.1 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Vitamin D binding protein, domain III Porphobil_deam PF01379.20 AMD20992.1 - 2.9e-75 252.3 0.0 3.8e-75 251.9 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 AMD20992.1 - 7.4e-21 74.3 0.3 1.3e-20 73.6 0.3 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Phage_int_SAM_3 PF14659.6 AMD20993.1 - 0.83 10.0 9.4 1.9 8.8 0.2 3.5 4 0 0 4 4 4 0 Phage integrase, N-terminal SAM-like domain Flavokinase PF01687.17 AMD20994.1 - 5.2e-30 104.0 0.0 6.9e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase GLE1 PF07817.13 AMD20995.1 - 1.5e-82 276.6 0.0 1.5e-82 276.6 0.0 1.7 2 0 0 2 2 2 1 GLE1-like protein Caldesmon PF02029.15 AMD20995.1 - 0.0028 16.5 22.1 0.0036 16.1 22.1 1.1 1 0 0 1 1 1 1 Caldesmon Activator_LAG-3 PF11498.8 AMD20995.1 - 0.0046 16.0 12.6 0.0068 15.4 12.6 1.3 1 0 0 1 1 1 1 Transcriptional activator LAG-3 GST_N_4 PF17172.4 AMD20995.1 - 0.017 15.9 0.0 0.057 14.2 0.0 1.9 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Asp-B-Hydro_N PF05279.11 AMD20995.1 - 0.16 12.0 19.1 0.24 11.4 19.1 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CDC45 PF02724.14 AMD20995.1 - 0.42 8.8 15.6 0.59 8.4 15.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.6 AMD20995.1 - 0.91 8.8 16.7 1.5 8.1 16.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDHD PF02862.17 AMD20995.1 - 1.3 9.2 5.7 2.1 8.4 5.7 1.5 1 0 0 1 1 1 0 DDHD domain DUF3772 PF12607.8 AMD20995.1 - 2.5 7.9 6.8 6.8 6.5 6.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Hid1 PF12722.7 AMD20995.1 - 2.6 6.0 13.0 4 5.4 13.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 AMD20995.1 - 4.1 6.1 14.0 5.6 5.6 14.0 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 AMD20995.1 - 4.9 7.1 9.5 7.5 6.5 9.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Endostatin PF06482.11 AMD20995.1 - 9.4 5.6 9.6 14 5.0 9.6 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Ribosomal_L5_C PF00673.21 AMD20996.1 - 2e-26 92.0 0.0 3.3e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AMD20996.1 - 1.1e-10 41.6 0.0 2.2e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 Adaptin_N PF01602.20 AMD20997.1 - 2.1e-103 346.7 16.8 2.1e-103 346.7 16.8 1.5 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 AMD20997.1 - 2.2e-53 179.6 0.0 6e-53 178.2 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 AMD20997.1 - 6.1e-50 168.8 1.0 1.5e-49 167.5 0.0 2.2 2 0 0 2 2 2 1 Coatomer beta C-terminal region Cnd1 PF12717.7 AMD20997.1 - 2.7e-08 34.0 12.5 6.6e-07 29.5 0.3 3.8 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD20997.1 - 3.2e-07 30.7 2.2 1.4 9.4 0.0 4.9 1 1 2 4 4 4 2 HEAT repeats DUF5578 PF17741.1 AMD20997.1 - 0.0043 16.5 9.4 0.0067 15.9 1.8 2.9 2 1 1 3 3 3 2 Family of unknown function (DUF5578) Alpha_adaptinC2 PF02883.20 AMD20997.1 - 0.0072 16.6 0.0 0.026 14.8 0.0 1.9 2 0 0 2 2 2 1 Adaptin C-terminal domain HAUS6_N PF14661.6 AMD20997.1 - 0.013 15.1 0.3 0.12 11.9 0.1 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus AP4E_app_platf PF14807.6 AMD20997.1 - 0.014 15.7 0.2 0.087 13.2 0.0 2.5 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform Vac14_Fab1_bd PF12755.7 AMD20997.1 - 0.078 13.6 0.1 0.43 11.2 0.1 2.3 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region HEPN_AbiV PF18728.1 AMD20999.1 - 0.0022 18.2 0.3 0.0047 17.1 0.3 1.5 1 0 0 1 1 1 1 AbiV Ribosomal_L7Ae PF01248.26 AMD21000.1 - 8.2e-28 96.0 0.5 1.2e-27 95.5 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF374 PF04028.13 AMD21000.1 - 0.13 11.9 0.1 0.66 9.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF374) UPF0147 PF03685.13 AMD21000.1 - 0.17 11.9 0.0 0.36 10.9 0.0 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0147) MKT1_C PF12246.8 AMD21001.1 - 8.6e-57 192.1 0.3 1.1e-55 188.5 0.4 2.1 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 AMD21001.1 - 1.3e-27 96.0 0.1 5.7e-27 93.9 0.1 2.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 AMD21001.1 - 6e-18 65.2 0.0 2.3e-17 63.3 0.0 2.0 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 AMD21001.1 - 0.0045 17.3 0.0 0.03 14.7 0.0 2.4 2 1 0 2 2 2 1 XPG I-region OST3_OST6 PF04756.13 AMD21002.1 - 1.1e-81 274.4 4.2 1.4e-81 274.1 4.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 AMD21002.1 - 0.00062 20.0 1.0 0.33 11.3 0.0 3.8 4 0 0 4 4 4 1 Thioredoxin-like Thioredoxin PF00085.20 AMD21002.1 - 0.019 14.9 0.0 0.086 12.8 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin DUF4064 PF13273.6 AMD21002.1 - 2.1 8.7 7.2 4.9 7.5 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Snapin_Pallidin PF14712.6 AMD21003.1 - 3.5e-05 24.2 1.3 4.3e-05 23.9 1.3 1.1 1 0 0 1 1 1 1 Snapin/Pallidin YscO PF07321.12 AMD21003.1 - 0.012 15.6 4.7 0.15 12.0 4.7 2.0 1 1 0 1 1 1 0 Type III secretion protein YscO NPV_P10 PF05531.12 AMD21003.1 - 0.03 14.8 0.7 0.18 12.3 0.7 2.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein C2 PF00168.30 AMD21004.1 - 1.2e-57 192.6 0.3 1e-21 77.1 0.0 4.7 4 0 0 4 4 4 4 C2 domain DNA_topoisoIV PF00521.20 AMD21005.1 - 1.1e-122 410.1 0.1 1.1e-122 410.1 0.1 2.1 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 AMD21005.1 - 9.6e-47 158.4 0.6 9.6e-47 158.4 0.6 2.9 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 AMD21005.1 - 2.5e-24 85.7 5.7 6.6e-24 84.3 5.7 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 AMD21005.1 - 1.3e-12 48.3 0.0 3e-12 47.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 AMD21005.1 - 5.4e-08 33.0 0.1 2.8e-07 30.7 0.0 2.3 2 0 0 2 2 2 1 Toprim domain BRCT PF00533.26 AMD21005.1 - 1.6 9.1 4.9 15 6.1 0.3 3.4 2 1 1 3 3 3 0 BRCA1 C Terminus (BRCT) domain Mito_carr PF00153.27 AMD21006.1 - 5.9e-45 151.1 7.7 4.9e-18 64.8 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NMT1 PF09084.11 AMD21007.1 - 2.7e-79 266.1 0.0 3.4e-79 265.8 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 AMD21007.1 - 1.6e-05 24.7 0.0 0.059 13.1 0.0 2.5 3 0 0 3 3 3 2 NMT1-like family RHH_5 PF07878.11 AMD21007.1 - 0.025 14.5 0.0 0.42 10.5 0.0 2.5 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 MHB PF16525.5 AMD21007.1 - 0.029 14.6 0.0 0.079 13.2 0.0 1.7 1 0 0 1 1 1 0 Haemophore, haem-binding Phosphonate-bd PF12974.7 AMD21007.1 - 0.17 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Cu-oxidase_2 PF07731.14 AMD21008.1 - 2.6e-37 127.6 2.8 2e-33 115.0 0.0 3.4 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AMD21008.1 - 2.2e-36 124.5 0.6 4.4e-35 120.3 0.3 2.9 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 AMD21008.1 - 9e-30 103.9 0.4 3.3e-29 102.0 0.0 2.1 2 1 0 2 2 2 1 Multicopper oxidase Monooxygenase_B PF04744.12 AMD21008.1 - 0.18 10.6 0.0 0.45 9.3 0.0 1.6 2 0 0 2 2 2 0 Monooxygenase subunit B protein Phosphoesterase PF04185.14 AMD21009.1 - 1.6e-39 136.1 1.0 4.4e-39 134.7 1.0 1.7 1 1 0 1 1 1 1 Phosphoesterase family SET PF00856.28 AMD21010.1 - 1.3e-11 45.2 0.0 2.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 SET domain HTH_Tnp_Tc5 PF03221.16 AMD21011.1 - 4.4e-14 52.3 0.7 1.2e-13 50.8 0.7 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF4817 PF16087.5 AMD21011.1 - 0.0061 16.3 0.2 0.014 15.2 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain (DUF4817) AvrM-A PF18241.1 AMD21011.1 - 0.018 15.5 2.2 0.034 14.6 2.2 1.5 1 0 0 1 1 1 0 Flax-rust effector AvrM-A MICSWaP PF17018.5 AMD21011.1 - 0.029 13.9 0.1 0.048 13.2 0.1 1.3 1 0 0 1 1 1 0 Spore wall protein Cofilin_ADF PF00241.20 AMD21012.1 - 7.3e-41 138.8 0.2 8.2e-41 138.6 0.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dynamitin PF04912.14 AMD21013.1 - 0.039 13.3 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Dynamitin CorA PF01544.18 AMD21013.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein ABC_tran PF00005.27 AMD21014.1 - 2.1e-58 196.7 0.2 5.2e-34 117.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 AMD21014.1 - 3.1e-54 184.5 44.5 5.2e-35 121.4 5.9 4.8 4 1 1 5 5 4 4 ABC transporter transmembrane region AAA_23 PF13476.6 AMD21014.1 - 4.9e-09 37.0 3.1 0.00029 21.4 0.7 2.6 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 AMD21014.1 - 3.3e-08 33.7 0.2 0.013 15.3 0.0 3.6 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AMD21014.1 - 1.9e-07 30.7 0.5 0.0014 18.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 AMD21014.1 - 2.1e-07 30.6 8.9 0.0005 19.6 1.8 4.4 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AMD21014.1 - 7.9e-06 25.8 4.5 0.037 13.7 0.9 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 AMD21014.1 - 4.7e-05 23.4 2.0 0.095 12.6 0.0 3.1 3 0 0 3 3 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AMD21014.1 - 7.2e-05 22.8 0.1 0.029 14.5 0.1 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 AMD21014.1 - 9.3e-05 22.3 0.1 3.5 7.4 0.0 3.5 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein DUF87 PF01935.17 AMD21014.1 - 0.0014 18.8 1.6 0.88 9.6 0.0 3.3 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_16 PF13191.6 AMD21014.1 - 0.0014 19.0 0.0 1.7 9.0 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 AMD21014.1 - 0.002 17.6 0.4 0.89 9.0 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 AMD21014.1 - 0.0022 18.3 0.7 3.7 7.8 0.1 3.0 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 AMD21014.1 - 0.0031 16.6 0.2 0.55 9.3 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 AMD21014.1 - 0.011 15.2 0.0 4 6.7 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 AMD21014.1 - 0.014 15.2 0.4 0.72 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 AMD21014.1 - 0.021 14.5 0.6 5.6 6.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain ArAE_1 PF06081.11 AMD21014.1 - 0.034 14.3 4.8 0.14 12.3 4.8 2.0 1 0 0 1 1 1 0 Aromatic acid exporter family member 1 Zeta_toxin PF06414.12 AMD21014.1 - 0.1 11.9 0.0 4.5 6.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 AMD21014.1 - 0.11 13.0 0.3 17 5.8 0.0 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 AMD21014.1 - 0.12 12.5 0.0 5.4 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 AMD21014.1 - 0.13 12.4 1.3 31 4.8 0.1 3.2 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 AMD21014.1 - 0.81 9.3 3.7 3.4 7.2 0.6 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RRM_1 PF00076.22 AMD21015.1 - 3.5e-18 65.2 3.9 5.3e-11 42.2 0.4 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) T2SSM PF04612.12 AMD21015.1 - 0.013 15.5 0.5 0.023 14.7 0.5 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Hydin_ADK PF17213.3 AMD21015.1 - 0.029 14.6 0.2 0.14 12.4 0.0 2.0 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain RRM_7 PF16367.5 AMD21015.1 - 0.072 13.2 0.1 1.2 9.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif RRM_Rrp7 PF17799.1 AMD21015.1 - 0.23 11.3 2.0 1.5 8.6 0.0 2.8 3 1 0 3 3 3 0 Rrp7 RRM-like N-terminal domain Ribosomal_L7Ae PF01248.26 AMD21016.1 - 7.8e-23 80.0 0.3 1.3e-22 79.3 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FGGY_C PF02782.16 AMD21017.1 - 2.6e-73 246.0 0.4 5.9e-72 241.5 0.2 2.1 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 AMD21017.1 - 1.7e-47 162.0 0.1 4.9e-40 137.6 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 AMD21017.1 - 0.059 12.8 0.1 0.57 9.6 0.0 2.5 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family MIP PF00230.20 AMD21018.1 - 1.7e-59 201.3 10.5 2.4e-59 200.8 10.5 1.1 1 0 0 1 1 1 1 Major intrinsic protein V-SNARE_C PF12352.8 AMD21019.1 - 1.8e-15 57.0 3.7 1.8e-15 57.0 3.7 2.6 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Spc7 PF08317.11 AMD21019.1 - 0.0098 14.8 7.1 0.013 14.4 7.1 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein SGIII PF15467.6 AMD21019.1 - 0.066 12.5 7.6 0.39 9.9 7.6 1.9 1 1 0 1 1 1 0 Secretogranin-3 APG6_N PF17675.1 AMD21019.1 - 0.067 13.7 14.6 0.068 13.7 6.8 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region OmpH PF03938.14 AMD21019.1 - 0.24 11.7 4.9 0.2 12.0 3.6 1.5 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 AMD21019.1 - 1.7 8.2 14.6 4.4 6.8 14.6 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF724 PF05266.14 AMD21019.1 - 1.8 8.3 8.3 0.78 9.5 4.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FliT PF05400.13 AMD21019.1 - 4.3 8.2 9.5 1.6 9.6 4.8 2.5 1 1 2 3 3 3 0 Flagellar protein FliT Syntaxin-6_N PF09177.11 AMD21019.1 - 4.8 7.8 12.9 0.45 11.1 3.2 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Autophagy_act_C PF03987.15 AMD21020.1 - 7.7e-05 23.2 1.5 0.00017 22.1 1.5 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Fer2_3 PF13085.6 AMD21021.1 - 4.7e-34 116.7 0.1 8.1e-34 115.9 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 AMD21021.1 - 5.2e-10 39.7 8.9 5.2e-10 39.7 8.9 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 AMD21021.1 - 9e-08 32.5 9.8 9e-08 32.5 9.8 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 AMD21021.1 - 1.9e-07 31.0 5.2 1.9e-07 31.0 5.2 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 AMD21021.1 - 0.011 15.6 1.1 0.011 15.6 1.1 2.5 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain SF3a60_bindingd PF12108.8 AMD21021.1 - 0.035 14.0 0.3 0.063 13.2 0.3 1.4 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain Fer4_18 PF13746.6 AMD21021.1 - 0.27 11.4 5.4 1.1 9.4 1.2 2.4 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 AMD21021.1 - 0.28 11.4 15.0 0.097 12.8 9.6 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 AMD21021.1 - 2.8 8.6 18.7 0.12 13.0 10.5 2.8 2 2 1 3 3 3 0 4Fe-4S dicluster domain SHR-BD PF06650.12 AMD21022.1 - 4.3e-95 318.2 6.3 1.1e-90 303.8 0.0 4.7 5 0 0 5 5 5 3 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 AMD21022.1 - 6.8e-80 267.9 5.2 8e-79 264.4 0.1 4.5 5 0 0 5 5 5 1 Repeating coiled region of VPS13 VPS13_C PF16909.5 AMD21022.1 - 5.2e-76 254.4 6.4 2.5e-69 232.6 0.7 2.9 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 AMD21022.1 - 3.6e-68 229.9 12.0 3.9e-68 229.8 3.6 3.8 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 AMD21022.1 - 7.3e-37 126.0 0.2 3.8e-36 123.7 0.0 2.5 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 AMD21022.1 - 0.037 14.4 0.1 0.089 13.1 0.1 1.6 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain Ecm29 PF13001.7 AMD21023.1 - 3.8e-136 454.7 5.9 3.8e-136 454.7 5.9 3.6 4 0 0 4 4 4 1 Proteasome stabiliser HEAT PF02985.22 AMD21023.1 - 4.5e-10 38.9 1.2 1.5 9.3 0.0 7.3 6 0 0 6 6 6 3 HEAT repeat CLASP_N PF12348.8 AMD21023.1 - 0.00047 19.8 0.0 0.9 9.1 0.0 3.8 2 1 0 2 2 2 2 CLASP N terminal Vac14_Fab1_bd PF12755.7 AMD21023.1 - 0.0034 17.9 0.0 0.29 11.8 0.0 4.2 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region PAP2 PF01569.21 AMD21023.1 - 0.083 12.7 0.0 1.4 8.7 0.0 2.4 2 0 0 2 2 2 0 PAP2 superfamily ubiquitin PF00240.23 AMD21024.1 - 6.1e-102 333.5 13.3 2e-33 114.0 0.6 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 AMD21024.1 - 1.5e-48 162.5 13.8 1.2e-15 57.1 0.7 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AMD21024.1 - 8.7e-18 64.6 6.0 0.00027 21.3 0.1 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain Ubiquitin_5 PF18037.1 AMD21024.1 - 1.7e-12 47.5 2.3 0.016 15.5 0.1 3.1 1 1 1 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 AMD21024.1 - 1.9e-12 46.9 1.7 0.017 15.0 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 AMD21024.1 - 4.7e-11 42.8 1.2 0.076 13.1 0.0 3.9 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 AMD21024.1 - 8.6e-10 39.1 0.5 0.19 12.3 0.0 3.2 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 AMD21024.1 - 1.1e-08 35.1 0.4 0.17 11.7 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 AMD21024.1 - 2.8e-06 27.3 16.0 11 6.1 0.2 6.0 6 0 0 6 6 6 0 Ubiquitin-like domain DUF3861 PF12977.7 AMD21024.1 - 9.4e-05 22.5 1.0 8.3 6.7 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 AMD21024.1 - 0.00016 21.4 2.1 7.1 6.6 0.0 3.3 3 0 0 3 3 3 0 ACT domain DUF2870 PF11069.8 AMD21024.1 - 0.00025 21.3 0.0 18 5.8 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 AMD21024.1 - 0.0006 19.2 0.1 1.2 8.5 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase Big_7 PF17957.1 AMD21024.1 - 0.0012 19.5 0.1 35 5.3 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig domain YcgR_2 PF12945.7 AMD21024.1 - 0.0033 17.5 2.9 20 5.4 0.1 3.3 3 0 0 3 3 3 0 Flagellar protein YcgR DUF969 PF06149.12 AMD21024.1 - 0.0066 15.9 0.0 15 4.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) UDP-g_GGTase PF06427.11 AMD21024.1 - 0.0075 16.4 3.0 4.6 7.4 0.0 3.1 4 0 0 4 4 3 2 UDP-glucose:Glycoprotein Glucosyltransferase DUF493 PF04359.14 AMD21024.1 - 0.033 14.8 0.0 98 3.6 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF493) Raf1_HTH PF18579.1 AMD21024.1 - 0.033 13.9 0.0 73 3.2 0.0 3.2 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain ACT_4 PF13291.6 AMD21024.1 - 0.035 14.7 0.3 98 3.6 0.0 3.3 3 0 0 3 3 3 0 ACT domain ORF11CD3 PF10549.9 AMD21024.1 - 0.093 12.9 0.0 64 3.8 0.0 3.4 3 0 0 3 3 3 0 ORF11CD3 domain ProRS-C_2 PF09181.10 AMD21024.1 - 0.13 12.4 2.6 74 3.6 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 AMD21024.1 - 0.14 12.3 18.4 4.6 7.5 1.4 3.3 3 0 0 3 3 3 0 Tash protein PEST motif Myosin_N PF02736.19 AMD21024.1 - 0.29 11.0 3.4 78 3.2 0.0 4.3 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain DMA PF03474.14 AMD21024.1 - 0.58 9.8 2.2 93 2.7 0.1 3.2 3 0 0 3 3 3 0 DMRTA motif Plexin_cytopl PF08337.12 AMD21024.1 - 0.76 8.4 10.9 9 4.8 0.4 3.9 2 1 0 4 4 4 0 Plexin cytoplasmic RasGAP domain PI3K_p85B PF02192.16 AMD21024.1 - 0.93 9.3 5.0 69 3.3 0.1 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain FlgD_ig PF13860.6 AMD21024.1 - 3.1 7.7 4.9 1.2e+02 2.6 0.1 3.3 3 0 0 3 3 3 0 FlgD Ig-like domain ENTH PF01417.20 AMD21025.1 - 1.9e-28 99.0 4.1 2.5e-28 98.6 4.1 1.2 1 0 0 1 1 1 1 ENTH domain DUF1539 PF07560.11 AMD21025.1 - 1.3 9.1 5.8 6.1 7.0 4.5 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) Prp19 PF08606.11 AMD21026.1 - 2.2e-30 104.5 0.5 3.8e-30 103.7 0.5 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.15 AMD21026.1 - 0.0019 18.3 0.1 0.0051 17.0 0.1 1.7 1 0 0 1 1 1 1 U-box domain ATG16 PF08614.11 AMD21026.1 - 0.025 14.8 0.6 0.049 13.9 0.6 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4221 PF13970.6 AMD21026.1 - 0.035 13.7 0.9 0.16 11.5 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4221) Cys_Met_Meta_PP PF01053.20 AMD21027.1 - 2e-114 382.1 0.0 2.3e-114 381.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Glyco_hydro_31 PF01055.26 AMD21027.1 - 0.098 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 Zn_clus PF00172.18 AMD21028.1 - 4.8e-08 33.0 9.2 4.8e-08 33.0 9.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 AMD21028.1 - 0.00034 19.7 1.1 0.00034 19.7 1.1 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 AMD21029.1 - 1.8e-13 50.1 11.0 6.2e-07 29.5 1.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD21029.1 - 9.2e-10 38.5 8.8 0.00015 22.3 0.4 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AMD21029.1 - 4.2e-09 36.5 4.1 0.00086 19.5 0.3 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 AMD21029.1 - 5.1e-08 33.0 17.1 2.8e-07 30.6 2.2 3.9 4 0 0 4 4 4 1 Zinc-finger double domain zf-met PF12874.7 AMD21029.1 - 9.7e-06 25.8 4.4 0.028 14.8 0.8 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AMD21029.1 - 2.9e-05 23.9 6.9 0.001 19.0 0.3 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 AMD21029.1 - 0.00093 19.4 1.7 0.0016 18.7 1.7 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 AMD21029.1 - 0.0021 18.5 3.5 0.14 12.7 0.2 2.6 1 1 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 AMD21029.1 - 0.0049 16.9 7.3 0.081 13.0 0.6 2.5 1 1 1 2 2 2 2 BED zinc finger zf-H2C2_5 PF13909.6 AMD21029.1 - 0.0087 15.8 4.7 0.73 9.7 0.9 2.5 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-CHCC PF10276.9 AMD21029.1 - 0.014 15.4 2.9 0.24 11.5 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger domain Actin_micro PF17003.5 AMD21029.1 - 0.022 14.0 2.3 0.099 11.8 1.6 2.2 2 1 0 2 2 2 0 Putative actin-like family zf-C2H2_3rep PF18868.1 AMD21029.1 - 0.084 13.5 1.6 9.6 6.9 0.1 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 AMD21029.1 - 0.094 13.1 4.1 7.1 7.0 0.3 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 AMD21029.1 - 0.097 12.6 8.0 2.7 8.0 0.3 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type PyrI_C PF02748.15 AMD21029.1 - 0.17 11.8 1.8 3.7 7.5 0.2 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF629 PF04780.12 AMD21029.1 - 0.54 8.7 4.6 2.8 6.4 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) HNH PF01844.23 AMD21029.1 - 1.2 9.4 4.5 8.2 6.7 0.4 2.7 2 0 0 2 2 2 0 HNH endonuclease zf-C2H2_11 PF16622.5 AMD21029.1 - 1.3 8.9 4.0 16 5.4 0.0 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Mnd1 PF03962.15 AMD21030.1 - 1.3e-26 92.6 0.9 3.4e-26 91.3 0.9 1.8 1 0 0 1 1 1 1 Mnd1 HTH domain LZ3wCH PF18517.1 AMD21030.1 - 0.0041 17.2 0.1 0.012 15.7 0.1 1.9 1 0 0 1 1 1 1 Leucine zipper with capping helix domain Alpha-2-MRAP_N PF06400.11 AMD21030.1 - 0.03 14.3 2.4 0.03 14.3 2.4 2.3 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, N-terminal domain EzrA PF06160.12 AMD21030.1 - 0.039 12.1 12.6 0.11 10.6 6.6 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 AMD21030.1 - 0.039 13.3 1.6 0.063 12.6 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nsp1_C PF05064.13 AMD21030.1 - 0.046 13.5 5.2 0.068 13.0 1.8 2.3 1 1 0 2 2 2 0 Nsp1-like C-terminal region CDPS PF16715.5 AMD21030.1 - 0.13 11.9 1.1 0.26 10.9 1.1 1.5 1 0 0 1 1 1 0 Cyclodipeptide synthase BLOC1_2 PF10046.9 AMD21030.1 - 0.13 12.6 7.1 0.52 10.6 5.1 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N PF02403.22 AMD21030.1 - 0.24 11.6 8.8 1.6 9.0 1.7 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3037 PF11236.8 AMD21030.1 - 0.33 11.4 3.5 2.8 8.4 1.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) DUF5339 PF17274.2 AMD21030.1 - 0.44 11.4 4.5 8.2 7.4 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5339) Exonuc_VII_L PF02601.15 AMD21030.1 - 0.75 9.3 6.9 0.74 9.3 6.1 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit CENP-F_leu_zip PF10473.9 AMD21030.1 - 1.1 9.3 14.3 0.6 10.1 10.9 2.2 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_23 PF13476.6 AMD21030.1 - 1.2 9.6 12.1 56 4.2 12.1 2.1 1 1 0 1 1 1 0 AAA domain ADIP PF11559.8 AMD21030.1 - 1.4 9.0 12.9 2.1 8.4 6.0 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.12 AMD21030.1 - 1.4 9.5 4.6 5 7.7 0.9 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 AMD21030.1 - 2 8.8 6.4 12 6.3 1.0 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF3578 PF12102.8 AMD21030.1 - 2.3 7.8 6.8 0.13 11.8 0.4 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3578) Syntaxin-6_N PF09177.11 AMD21030.1 - 2.9 8.5 10.3 5 7.7 5.8 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF16 PF01519.16 AMD21030.1 - 6 7.4 12.2 3 8.4 1.6 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 ArfGap PF01412.18 AMD21031.1 - 7.9e-30 103.3 0.3 7.9e-30 103.3 0.3 2.6 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf UBA PF00627.31 AMD21031.1 - 0.12 12.3 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 0 UBA/TS-N domain DUF3543 PF12063.8 AMD21032.1 - 1.8e-74 250.3 3.2 3.5e-74 249.4 3.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 AMD21032.1 - 6.4e-58 196.2 0.0 1.2e-57 195.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21032.1 - 6.9e-45 153.4 0.0 1.2e-44 152.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase MHC_I_C PF06623.11 AMD21032.1 - 0.13 12.2 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 MHC_I C-terminus Pkinase PF00069.25 AMD21033.1 - 4e-53 180.4 0.0 8.1e-53 179.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21033.1 - 6.5e-26 91.2 0.1 1.2e-24 87.0 0.1 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD21033.1 - 0.0015 17.4 0.0 0.0032 16.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AMD21033.1 - 0.0016 17.8 0.0 0.022 14.1 0.0 2.2 1 1 0 1 1 1 1 Kinase-like Vfa1 PF08432.10 AMD21034.1 - 1.5e-37 129.6 7.8 1.9e-37 129.4 7.8 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 FdhE PF04216.12 AMD21034.1 - 0.041 13.8 1.6 1.3 8.8 0.3 2.1 1 1 1 2 2 2 0 Protein involved in formate dehydrogenase formation Sas10_Utp3 PF04000.15 AMD21035.1 - 3e-10 40.6 0.1 3e-10 40.6 0.1 2.1 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Peptidase_S8 PF00082.22 AMD21035.1 - 0.0079 15.5 0.7 0.011 15.0 0.7 1.2 1 0 0 1 1 1 1 Subtilase family Imm5 PF14423.6 AMD21035.1 - 0.071 13.3 0.1 0.071 13.3 0.1 1.7 2 0 0 2 2 2 0 Immunity protein Imm5 Alanine_zipper PF11839.8 AMD21035.1 - 0.12 12.8 0.5 0.12 12.8 0.5 3.1 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Ribosomal_S8e PF01201.22 AMD21036.1 - 3.3e-46 156.8 0.1 5.9e-46 156.0 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein S8e PUF PF00806.19 AMD21037.1 - 1.6e-54 178.6 34.1 7.8e-08 31.6 0.1 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat TF_AP-2 PF03299.14 AMD21037.1 - 2.4 8.1 9.3 7.8 6.4 9.3 1.9 1 0 0 1 1 1 0 Transcription factor AP-2 HECT PF00632.25 AMD21038.1 - 2e-94 316.5 0.0 2.6e-94 316.2 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 AMD21038.1 - 3.6e-34 116.5 23.8 2.8e-12 46.5 1.9 4.1 4 0 0 4 4 4 3 WW domain C2 PF00168.30 AMD21038.1 - 3.8e-18 65.7 0.1 1.2e-17 64.1 0.1 1.9 1 0 0 1 1 1 1 C2 domain Abhydrolase_6 PF12697.7 AMD21039.1 - 2.2e-10 41.5 0.0 3.6e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AMD21039.1 - 0.00062 19.5 0.3 0.0011 18.7 0.3 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AMD21039.1 - 0.0033 16.7 0.0 0.0081 15.5 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 AMD21039.1 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Whi5 PF08528.11 AMD21040.1 - 6.4e-11 41.6 0.6 1.3e-10 40.7 0.6 1.5 1 0 0 1 1 1 1 Whi5 like LIM PF00412.22 AMD21041.1 - 7.1e-15 55.0 24.5 2.8e-09 37.1 7.0 2.3 2 0 0 2 2 2 2 LIM domain DUF3336 PF11815.8 AMD21042.1 - 4.5e-33 113.9 9.4 1e-32 112.8 9.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 AMD21042.1 - 8.8e-25 88.1 0.0 1.7e-24 87.2 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase TPR_1 PF00515.28 AMD21043.1 - 1.1e-05 25.0 10.4 0.021 14.7 0.5 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD21043.1 - 1.7e-05 24.5 5.0 0.36 11.1 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat F-box PF00646.33 AMD21043.1 - 0.00088 19.1 1.1 0.0045 16.8 1.1 2.2 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 AMD21043.1 - 0.0014 18.5 0.5 0.0066 16.3 0.5 2.3 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 AMD21043.1 - 0.0052 16.5 5.0 1.4 8.8 0.8 5.3 3 1 1 4 4 4 1 Leucine rich repeat TPR_8 PF13181.6 AMD21043.1 - 0.043 14.0 2.5 0.53 10.6 0.3 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 AMD21043.1 - 0.05 13.9 0.4 3.8 7.9 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 AMD21043.1 - 0.12 12.4 4.4 2.3 8.4 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 AMD21043.1 - 0.13 12.4 0.6 29 4.8 0.0 2.8 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain LRR_4 PF12799.7 AMD21043.1 - 0.67 10.5 25.1 4.6 7.8 0.1 7.2 4 2 3 7 7 7 0 Leucine Rich repeats (2 copies) Zip PF02535.22 AMD21044.1 - 8.3e-31 107.4 14.8 1.3e-16 60.7 8.2 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter U3_snoRNA_assoc PF08297.11 AMD21045.1 - 1.5e-15 57.6 6.3 1.5e-15 57.6 6.3 3.0 2 1 0 2 2 2 1 U3 snoRNA associated Orf78 PF06024.12 AMD21045.1 - 0.18 12.1 0.1 0.18 12.1 0.1 2.7 2 1 0 2 2 2 0 Orf78 (ac78) SNARE_assoc PF09335.11 AMD21047.1 - 8.2e-14 52.1 11.3 7.3e-13 49.1 6.9 2.9 2 1 1 3 3 3 1 SNARE associated Golgi protein SeqA_N PF17206.3 AMD21047.1 - 0.06 12.7 0.1 0.13 11.6 0.1 1.5 1 0 0 1 1 1 0 SeqA protein N-terminal domain DUF4229 PF14012.6 AMD21047.1 - 1.6 8.9 5.8 6.7 6.9 5.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4229) YrhC PF14143.6 AMD21047.1 - 2.3 8.4 5.3 0.49 10.5 0.2 2.5 3 0 0 3 3 3 0 YrhC-like protein Kin17_mid PF10357.9 AMD21048.1 - 6.4e-45 152.1 7.2 9.4e-45 151.6 7.2 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 AMD21048.1 - 1e-05 25.6 0.9 3.3e-05 24.0 0.9 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AMD21048.1 - 0.0025 18.2 1.4 0.0025 18.2 1.4 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 AMD21048.1 - 0.009 16.3 0.9 0.009 16.3 0.9 2.5 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) TFIID_NTD2 PF04494.15 AMD21048.1 - 0.017 15.3 0.8 0.017 15.3 0.8 1.8 2 0 0 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain RL PF17797.1 AMD21048.1 - 0.09 12.7 0.3 0.21 11.6 0.3 1.6 1 0 0 1 1 1 0 RL domain zf-C2H2_4 PF13894.6 AMD21048.1 - 1 10.4 4.0 1.8 9.6 0.8 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger AKAP95 PF04988.12 AMD21048.1 - 1.4 9.2 8.8 0.3 11.3 5.3 1.7 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) Peptidase_M48 PF01435.18 AMD21049.1 - 9.8e-24 84.2 0.1 8e-23 81.2 0.1 1.9 1 1 0 1 1 1 1 Peptidase family M48 HA2 PF04408.23 AMD21050.1 - 3.7e-22 78.6 0.4 1.7e-21 76.5 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AMD21050.1 - 1.5e-14 54.1 0.0 3.4e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AMD21050.1 - 2.9e-14 53.4 0.1 9.4e-14 51.7 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD21050.1 - 6.7e-08 32.5 0.0 1.5e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AMD21050.1 - 7.8e-05 23.0 0.0 0.00026 21.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 AMD21050.1 - 0.012 15.7 0.0 6.9 6.6 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 AMD21050.1 - 0.015 15.0 1.4 4 7.1 0.0 2.8 2 1 1 3 3 3 0 IstB-like ATP binding protein AAA_19 PF13245.6 AMD21050.1 - 0.016 15.5 0.0 0.067 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 AMD21050.1 - 0.026 14.2 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 AMD21050.1 - 0.029 14.3 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain ATPase PF06745.13 AMD21050.1 - 0.038 13.3 0.1 0.099 12.0 0.1 1.6 1 0 0 1 1 1 0 KaiC T2SSE PF00437.20 AMD21050.1 - 0.042 12.9 0.0 0.088 11.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 AMD21050.1 - 0.085 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MRP-L20 PF12824.7 AMD21051.1 - 2.9e-46 157.6 3.2 3.6e-46 157.3 3.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_3 PF01381.22 AMD21051.1 - 0.017 15.2 0.1 0.39 10.8 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix GTP_EFTU PF00009.27 AMD21053.1 - 5e-41 140.4 0.0 7.9e-41 139.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 AMD21053.1 - 1.9e-11 44.1 5.4 5.4e-11 42.6 5.4 1.7 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 AMD21053.1 - 5.8e-07 29.8 0.0 1.3e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 AMD21053.1 - 1.9e-05 24.7 0.0 0.0002 21.4 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 AMD21053.1 - 6.8e-05 23.2 0.0 0.00016 22.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Arf PF00025.21 AMD21053.1 - 0.0093 15.4 0.2 3.5 7.1 0.0 2.6 3 0 0 3 3 3 2 ADP-ribosylation factor family FeoB_N PF02421.18 AMD21053.1 - 0.11 12.0 0.1 1.4 8.5 0.1 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B tRNA-synt_2c PF01411.19 AMD21054.1 - 1.3e-224 746.8 0.4 5.3e-224 744.8 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 AMD21054.1 - 2.2e-19 69.3 0.1 6.3e-19 67.8 0.1 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 AMD21054.1 - 8.8e-14 52.1 3.6 1.9e-13 51.0 3.6 1.6 1 0 0 1 1 1 1 DHHA1 domain RPW8 PF05659.11 AMD21054.1 - 0.083 12.6 0.7 0.87 9.3 0.0 2.7 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DNase_II PF03265.15 AMD21054.1 - 0.13 11.5 0.2 3.9 6.7 0.0 2.6 3 0 0 3 3 3 0 Deoxyribonuclease II Glyco_transf_24 PF18404.1 AMD21055.1 - 3e-32 112.1 2.3 5.8e-32 111.2 2.3 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 AMD21055.1 - 1.5e-15 57.8 0.1 1.6e-13 51.2 0.0 3.0 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 AMD21055.1 - 1.7e-07 31.3 0.0 3.3e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain CUE PF02845.16 AMD21055.1 - 0.00077 19.1 0.5 0.026 14.2 0.0 3.5 4 0 0 4 4 4 1 CUE domain ThiS-like PF14453.6 AMD21055.1 - 0.005 16.9 0.4 2 8.5 0.1 2.9 2 0 0 2 2 2 2 ThiS-like ubiquitin MOR2-PAG1_N PF14222.6 AMD21055.1 - 0.048 12.6 0.0 0.085 11.8 0.0 1.3 1 0 0 1 1 1 0 Cell morphogenesis N-terminal DUF1647 PF07801.11 AMD21055.1 - 2.4 7.9 6.0 10 5.8 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1647) Fungal_trans PF04082.18 AMD21056.1 - 4.7e-19 68.4 0.3 8.4e-18 64.3 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD21056.1 - 2.4e-07 30.7 11.3 4.2e-07 30.0 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2054 PF10218.9 AMD21056.1 - 0.46 10.6 7.4 0.77 9.8 7.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2054) SWIRM PF04433.17 AMD21057.1 - 2.3e-09 37.5 0.0 4.3e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain Mis12 PF05859.12 AMD21058.1 - 1.6e-38 131.8 0.4 2.9e-38 131.0 0.4 1.4 1 0 0 1 1 1 1 Mis12 protein RAMPs PF03787.15 AMD21058.1 - 0.21 11.6 0.3 0.25 11.4 0.2 1.4 1 1 0 1 1 1 0 RAMP superfamily PK PF00224.21 AMD21059.1 - 6.8e-169 561.3 0.5 8.6e-169 560.9 0.5 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 AMD21059.1 - 4.8e-33 113.9 0.1 1.4e-32 112.4 0.1 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 AMD21059.1 - 2.4e-06 26.8 0.4 8.2e-06 25.1 0.2 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMS PF00817.20 AMD21060.1 - 1.5e-34 119.1 0.0 3.4e-34 118.0 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family BRCT_2 PF16589.5 AMD21060.1 - 1.4e-14 54.2 0.0 2.9e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain IMS_C PF11799.8 AMD21060.1 - 7.4e-12 46.0 0.0 1.9e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT PF00533.26 AMD21060.1 - 2.3e-08 34.3 0.0 7.2e-08 32.7 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 AMD21060.1 - 2.3e-06 27.8 0.0 4.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 AMD21060.1 - 0.0006 19.7 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain mCpol PF18182.1 AMD21060.1 - 0.00088 19.6 0.0 0.0027 18.0 0.0 1.8 1 0 0 1 1 1 1 minimal CRISPR polymerase domain REV1_C PF16727.5 AMD21060.1 - 0.0073 16.7 0.0 0.033 14.6 0.0 2.1 2 0 0 2 2 2 1 DNA repair protein REV1 C-terminal domain IMS_HHH PF11798.8 AMD21060.1 - 0.012 15.9 0.0 0.042 14.2 0.0 2.0 2 0 0 2 2 2 0 IMS family HHH motif RTT107_BRCT_5 PF16770.5 AMD21060.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain HLH PF00010.26 AMD21061.1 - 8.1e-19 67.3 0.1 1.9e-18 66.1 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PMSI1 PF15322.6 AMD21061.1 - 0.038 13.4 2.6 0.051 13.0 2.6 1.3 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative CDC45 PF02724.14 AMD21061.1 - 0.78 8.0 13.6 1.1 7.5 13.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 AMD21061.1 - 1 7.6 7.5 1.4 7.2 7.5 1.2 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 AMD21061.1 - 3.7 6.2 7.7 4.7 5.9 7.7 1.1 1 0 0 1 1 1 0 Presenilin MMR_HSR1_Xtn PF16897.5 AMD21063.1 - 3e-38 130.1 0.0 6.5e-38 129.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 AMD21063.1 - 5.4e-22 77.6 0.0 9.9e-22 76.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 AMD21063.1 - 1.3e-19 70.4 0.0 2.9e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD21063.1 - 6.9e-09 35.4 0.0 1.8e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 AMD21063.1 - 0.0096 14.9 0.1 0.025 13.6 0.2 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 AMD21063.1 - 0.015 15.4 0.3 6.4 6.8 0.3 2.4 1 1 1 2 2 2 0 Dynamin family AAA_22 PF13401.6 AMD21063.1 - 0.067 13.5 0.1 13 6.1 0.0 2.7 3 0 0 3 3 3 0 AAA domain Arf PF00025.21 AMD21063.1 - 0.087 12.3 0.1 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family TAXi_C PF14541.6 AMD21063.1 - 0.15 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal RsgA_GTPase PF03193.16 AMD21063.1 - 0.2 11.6 0.6 4.1 7.3 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase GTP_EFTU PF00009.27 AMD21064.1 - 4.6e-34 117.7 0.0 4.6e-34 117.7 0.0 2.7 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 AMD21064.1 - 7.9e-21 74.2 0.0 2.9e-20 72.4 0.0 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 AMD21064.1 - 1.4e-13 51.1 0.7 5.7e-09 36.2 0.0 3.2 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AMD21064.1 - 2e-06 27.9 3.8 7.1e-06 26.1 0.0 3.6 4 1 1 5 5 5 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 AMD21064.1 - 1.8e-05 24.6 0.2 6.1e-05 22.8 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu domain 4 RNA_pol_Rpb1_5 PF04998.17 AMD21065.1 - 1.8e-96 322.7 2.5 2e-96 322.5 0.3 2.2 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AMD21065.1 - 1.2e-69 233.8 0.2 2.8e-69 232.6 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AMD21065.1 - 4.1e-40 137.3 0.7 7.6e-38 129.9 0.0 3.2 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 AMD21065.1 - 6.4e-26 91.4 0.8 6.4e-26 91.4 0.8 3.3 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 AMD21065.1 - 2.3e-23 82.2 0.3 2.1e-22 79.1 0.0 2.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 CSRNP_N PF16019.5 AMD21065.1 - 0.41 10.5 3.4 1.3 8.9 3.4 1.8 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Isy1 PF06246.12 AMD21065.1 - 0.66 9.5 17.7 1.6 8.2 0.1 3.6 3 0 0 3 3 3 0 Isy1-like splicing family Fungal_trans PF04082.18 AMD21066.1 - 5.9e-13 48.4 0.2 1e-12 47.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD21066.1 - 9.6e-05 22.4 8.7 0.0002 21.4 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD-oxidase_C PF02913.19 AMD21066.1 - 0.2 11.3 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain RPA43_OB PF17875.1 AMD21067.1 - 1.1e-26 93.9 0.6 2e-26 93.0 0.1 1.8 2 0 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 AMD21067.1 - 5.2e-11 42.7 0.0 9.7e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Toxin_5 PF05294.13 AMD21068.1 - 0.16 12.4 0.5 0.37 11.3 0.5 1.6 1 0 0 1 1 1 0 Scorpion short toxin COG6 PF06419.11 AMD21069.1 - 6.7e-140 467.3 22.2 1e-139 466.6 22.2 1.3 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DDE_Tnp_IS66_C PF13817.6 AMD21069.1 - 0.12 12.6 0.1 30 5.0 0.0 3.0 2 0 0 2 2 2 0 IS66 C-terminal element Ribosomal_S30AE PF02482.19 AMD21069.1 - 0.18 12.6 0.2 1 10.2 0.0 2.4 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Diphthamide_syn PF01866.17 AMD21070.1 - 2.7e-114 381.7 0.1 3.7e-114 381.3 0.1 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein SHQ1 PF04925.15 AMD21071.1 - 3e-69 232.1 0.6 4.6e-69 231.5 0.6 1.3 1 0 0 1 1 1 1 SHQ1 protein DUF2722 PF10846.8 AMD21072.1 - 1.1e-21 77.3 11.1 2.5e-15 56.4 5.2 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF2722) PRA1 PF03208.19 AMD21073.1 - 4.7e-39 133.3 2.3 5.6e-39 133.0 2.3 1.0 1 0 0 1 1 1 1 PRA1 family protein DUF2207 PF09972.9 AMD21073.1 - 1.1 7.9 6.6 3.6 6.3 6.6 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) 2TM PF13239.6 AMD21073.1 - 1.9 8.8 5.2 18 5.7 1.2 2.2 2 0 0 2 2 2 0 2TM domain Peptidase_M1 PF01433.20 AMD21074.1 - 6.9e-43 146.7 1.5 1.1e-42 146.1 1.5 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 AMD21074.1 - 1.2e-29 102.6 0.3 4.1e-29 100.9 0.3 2.0 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 AMD21074.1 - 3e-21 76.5 0.0 5.1e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_MA_2 PF13485.6 AMD21074.1 - 0.063 12.9 0.7 0.14 11.8 0.2 1.7 2 0 0 2 2 2 0 Peptidase MA superfamily PH PF00169.29 AMD21075.1 - 2.6e-10 40.7 0.7 6.8e-10 39.4 0.7 1.8 1 0 0 1 1 1 1 PH domain OmpH PF03938.14 AMD21075.1 - 2.8 8.3 8.3 0.16 12.3 2.8 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ALG11_N PF15924.5 AMD21076.1 - 7.7e-80 267.9 1.6 1.1e-79 267.3 1.6 1.3 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 AMD21076.1 - 4.8e-16 58.8 0.0 1.3e-15 57.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AMD21076.1 - 2.6e-07 31.1 0.0 7.9e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AMD21076.1 - 0.0012 18.9 0.1 0.0029 17.6 0.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Mob1_phocein PF03637.17 AMD21077.1 - 2.7e-65 219.5 0.4 3.6e-65 219.1 0.4 1.1 1 0 0 1 1 1 1 Mob1/phocein family GFO_IDH_MocA PF01408.22 AMD21078.1 - 7.5e-20 71.9 0.4 1.9e-19 70.7 0.1 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 AMD21078.1 - 3.6e-07 30.2 0.0 6.9e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DUF4097 PF13349.6 AMD21078.1 - 0.043 13.1 0.6 0.061 12.7 0.6 1.2 1 0 0 1 1 1 0 Putative adhesin DCP1 PF06058.13 AMD21079.1 - 1.3e-25 89.6 0.0 5.1e-25 87.7 0.0 1.9 1 1 0 1 1 1 1 Dcp1-like decapping family DUF2185 PF09951.9 AMD21079.1 - 0.092 12.6 0.2 0.52 10.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2185) Spt20 PF12090.8 AMD21080.1 - 4.7e-69 232.6 11.3 4.7e-69 232.6 11.3 3.5 3 0 0 3 3 3 2 Spt20 family DUF4179 PF13786.6 AMD21080.1 - 2.1 8.9 8.2 1.9 9.0 0.6 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) PEX11 PF05648.14 AMD21081.1 - 1.2e-62 211.3 2.3 1.4e-62 211.1 2.3 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sld5 PF05916.11 AMD21082.1 - 8.4e-18 64.8 0.0 1.1e-17 64.5 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein TPR_2 PF07719.17 AMD21083.1 - 1.4e-23 81.0 36.9 5.7e-05 22.9 0.2 12.6 16 0 0 16 16 13 6 Tetratricopeptide repeat TPR_12 PF13424.6 AMD21083.1 - 1e-22 80.2 6.1 5.7e-05 23.3 0.0 9.0 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 AMD21083.1 - 1.7e-21 75.1 32.4 9.3e-05 22.1 0.0 11.5 13 0 0 13 13 11 6 Tetratricopeptide repeat TPR_16 PF13432.6 AMD21083.1 - 7.7e-19 68.1 0.0 3e-05 24.6 0.0 7.1 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 AMD21083.1 - 1.2e-16 61.0 25.3 0.0042 17.6 0.1 11.5 10 2 2 12 12 11 4 Tetratricopeptide repeat TPR_14 PF13428.6 AMD21083.1 - 1.5e-13 50.3 17.3 0.0023 18.6 0.0 11.6 12 3 4 16 16 11 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD21083.1 - 2.3e-10 40.6 15.3 0.00012 22.2 0.3 6.7 6 1 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 AMD21083.1 - 2.5e-08 33.5 23.6 0.0015 18.1 1.2 9.1 10 0 0 10 10 9 3 TPR repeat TPR_7 PF13176.6 AMD21083.1 - 1.6e-06 27.8 7.1 0.6 10.3 0.0 7.6 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 AMD21083.1 - 2.1e-06 27.7 13.0 15 6.2 0.0 10.1 11 0 0 11 11 10 0 Tetratricopeptide repeat TPR_8 PF13181.6 AMD21083.1 - 4.3e-06 26.5 43.0 0.078 13.2 0.0 11.9 15 0 0 15 15 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 AMD21083.1 - 8.4e-06 26.1 24.5 0.35 11.6 0.0 10.3 13 0 0 13 13 9 3 Tetratricopeptide repeat TPR_10 PF13374.6 AMD21083.1 - 1.9e-05 24.4 11.9 0.81 9.7 0.2 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 AMD21083.1 - 0.0005 20.2 3.3 0.048 13.8 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat PPR PF01535.20 AMD21083.1 - 0.0045 17.1 3.3 2 8.8 0.1 5.5 5 0 0 5 5 5 1 PPR repeat TPR_3 PF07720.12 AMD21083.1 - 0.018 15.0 10.2 1.8 8.6 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat RRM_1 PF00076.22 AMD21084.1 - 0.0001 22.0 0.2 0.00026 20.7 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DMRL_synthase PF00885.19 AMD21085.1 - 5.7e-55 185.0 0.5 7.1e-55 184.7 0.5 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Peptidase_C15 PF01470.17 AMD21085.1 - 0.11 12.7 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Pyroglutamyl peptidase Hist_deacetyl PF00850.19 AMD21086.1 - 5.7e-83 278.9 0.1 9.6e-83 278.2 0.0 1.4 2 0 0 2 2 2 1 Histone deacetylase domain AAA PF00004.29 AMD21087.1 - 5.9e-57 191.8 0.0 1.2e-43 148.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD21087.1 - 4.6e-08 32.7 0.3 0.0065 16.3 0.2 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 AMD21087.1 - 9.4e-07 29.4 0.0 0.03 14.7 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain Parvo_NS1 PF01057.17 AMD21087.1 - 0.00011 21.4 0.0 0.00022 20.4 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 RuvB_N PF05496.12 AMD21087.1 - 0.00041 20.1 0.0 0.0021 17.8 0.0 2.2 3 0 0 3 3 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 AMD21087.1 - 0.00063 20.1 0.0 0.027 14.9 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 AMD21087.1 - 0.0046 17.1 0.0 0.024 14.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 AMD21087.1 - 0.0052 17.0 0.0 0.68 10.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AMD21087.1 - 0.0056 17.0 0.0 0.058 13.7 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_7 PF12775.7 AMD21087.1 - 0.0066 16.0 0.0 0.028 13.9 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 AMD21087.1 - 0.0099 16.4 0.0 0.11 13.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 AMD21087.1 - 0.016 15.2 0.0 0.61 10.1 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 AMD21087.1 - 0.018 14.4 0.0 0.067 12.6 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 AMD21087.1 - 0.019 14.2 0.0 0.039 13.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 AMD21087.1 - 0.02 14.6 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PPV_E1_C PF00519.17 AMD21087.1 - 0.02 13.7 0.0 0.044 12.6 0.0 1.4 1 0 0 1 1 1 0 Papillomavirus helicase AAA_5 PF07728.14 AMD21087.1 - 0.02 14.9 0.0 0.087 12.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Imm6 PF14434.6 AMD21087.1 - 0.026 14.5 0.3 0.23 11.4 0.0 2.4 2 1 1 3 3 3 0 Immunity protein Imm6 ATPase PF06745.13 AMD21087.1 - 0.041 13.2 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_14 PF13173.6 AMD21087.1 - 0.05 13.6 0.0 1.4 9.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_3 PF07726.11 AMD21087.1 - 0.065 13.1 0.0 1.8 8.4 0.0 3.0 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 AMD21087.1 - 0.12 12.3 0.1 30 4.5 0.0 3.0 4 0 0 4 4 2 0 NACHT domain AAA_25 PF13481.6 AMD21087.1 - 0.15 11.6 0.0 1 8.9 0.0 2.2 1 1 1 2 2 2 0 AAA domain DUF1287 PF06940.11 AMD21087.1 - 0.17 11.5 0.2 0.38 10.4 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) CbiA PF01656.23 AMD21087.1 - 0.19 11.8 0.1 47 4.0 0.0 3.2 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain DnaJ PF00226.31 AMD21088.1 - 0.0016 18.5 0.1 0.0037 17.3 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Pesticin PF16754.5 AMD21088.1 - 0.023 14.7 0.1 1.2 9.1 0.0 2.2 1 1 1 2 2 2 0 Bacterial toxin homologue of phage lysozyme, C-term Pam16 PF03656.13 AMD21088.1 - 0.03 14.3 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 Pam16 DHHC PF01529.20 AMD21090.1 - 2e-34 118.6 10.7 2e-34 118.6 10.7 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase FtsX PF02687.21 AMD21090.1 - 4 8.0 9.9 0.099 13.1 1.7 2.3 2 1 0 2 2 2 0 FtsX-like permease family KH_6 PF15985.5 AMD21091.1 - 3.6e-12 46.4 0.0 6.2e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 AMD21091.1 - 9.4e-07 28.7 0.0 2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain E1_UFD PF09358.10 AMD21091.1 - 0.02 15.6 0.0 0.043 14.5 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin fold domain ECR1_N PF14382.6 AMD21091.1 - 0.095 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Exosome complex exonuclease RRP4 N-terminal region Syja_N PF02383.18 AMD21092.1 - 5.7e-79 265.7 1.9 8.1e-79 265.2 0.1 2.2 2 0 0 2 2 2 1 SacI homology domain DUF3533 PF12051.8 AMD21093.1 - 1.6e-109 366.3 5.7 1.9e-109 366.1 5.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) CDC50 PF03381.15 AMD21094.1 - 1.4e-85 287.2 0.8 1.8e-85 286.9 0.8 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family MARVEL PF01284.23 AMD21094.1 - 0.26 11.3 2.3 4.9 7.2 0.2 2.2 2 0 0 2 2 2 0 Membrane-associating domain KRE1 PF17056.5 AMD21095.1 - 2.5e-08 33.5 2.9 2.5e-08 33.5 2.9 2.1 2 1 0 2 2 2 1 Killer toxin-resistance protein 1 Keratin_B2_2 PF13885.6 AMD21095.1 - 0.0012 18.8 11.5 0.052 13.5 1.1 3.4 1 1 2 3 3 3 3 Keratin, high sulfur B2 protein ATP_bind_1 PF03029.17 AMD21096.1 - 6.6e-78 261.8 0.0 8.5e-78 261.5 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 AMD21096.1 - 0.0065 16.5 0.0 0.086 12.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase HUN PF08729.10 AMD21096.1 - 0.0078 16.2 0.1 0.019 15.0 0.1 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain AAA_22 PF13401.6 AMD21096.1 - 0.019 15.2 0.0 0.068 13.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 AMD21096.1 - 0.031 14.7 1.0 0.15 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 AMD21096.1 - 0.069 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 AMD21096.1 - 0.081 13.3 0.0 2.3 8.6 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AMD21096.1 - 0.17 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AMD21096.1 - 0.23 12.0 1.6 0.96 10.0 0.2 2.3 2 0 0 2 2 2 0 AAA domain MitMem_reg PF13012.6 AMD21097.1 - 9.8e-34 116.1 0.3 9.8e-34 116.1 0.3 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 AMD21097.1 - 1.4e-31 109.0 0.0 2.6e-31 108.0 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UbiA PF01040.18 AMD21098.1 - 4.4e-47 160.5 12.9 4.4e-47 160.5 12.9 1.5 1 1 0 1 1 1 1 UbiA prenyltransferase family Hexapep PF00132.24 AMD21099.1 - 5.2e-07 29.2 6.5 0.00019 21.0 3.9 3.5 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 AMD21099.1 - 3.4e-06 27.5 0.0 5.8e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 AMD21099.1 - 0.00068 19.3 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 AMD21099.1 - 0.00098 18.2 4.9 0.0014 17.7 2.4 2.3 2 1 1 3 3 3 1 L-fucokinase DUF4954 PF16314.5 AMD21099.1 - 0.0029 15.8 1.5 0.0029 15.8 1.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 AMD21099.1 - 0.014 15.1 10.8 0.22 11.3 2.4 3.3 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase E1-E2_ATPase PF00122.20 AMD21100.1 - 1.1e-35 122.8 27.1 8.4e-31 106.9 0.1 4.1 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 AMD21100.1 - 1.3e-26 93.5 6.1 1.3e-26 93.5 6.1 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 AMD21100.1 - 1.6e-20 74.3 0.0 7.3e-16 59.1 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AMD21100.1 - 1.5e-18 66.6 0.0 3.2e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AMD21100.1 - 2e-12 46.6 0.8 4.1e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AMD21100.1 - 0.00092 19.0 0.1 0.011 15.5 0.4 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Amidohydro_2 PF04909.14 AMD21100.1 - 0.17 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase Aminotran_5 PF00266.19 AMD21101.1 - 4.4e-13 48.9 0.0 6.3e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Zn_clus PF00172.18 AMD21102.1 - 3.9e-10 39.7 7.5 6.4e-10 39.0 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EST1_DNA_bind PF10373.9 AMD21103.1 - 2.4e-50 171.6 1.0 4.2e-50 170.8 0.0 1.8 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 AMD21103.1 - 9.9e-21 74.8 1.0 9.9e-21 74.8 1.0 3.0 3 1 0 3 3 3 1 Telomerase activating protein Est1 Topoisom_bac PF01131.20 AMD21104.1 - 1.4e-108 363.6 0.9 1.7e-108 363.3 0.9 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 AMD21104.1 - 3e-20 72.3 0.0 9.2e-20 70.8 0.0 1.9 1 0 0 1 1 1 1 Toprim domain ZIP4_domain PF18292.1 AMD21104.1 - 0.11 12.4 0.6 0.24 11.3 0.6 1.5 1 0 0 1 1 1 0 Zinc transporter ZIP4 domain Cation_efflux PF01545.21 AMD21105.1 - 5.2e-41 140.6 15.1 5.2e-41 140.6 15.1 2.8 2 1 0 3 3 3 1 Cation efflux family Coq4 PF05019.13 AMD21106.1 - 2.6e-89 298.3 0.0 3.2e-89 298.0 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF569 PF04601.13 AMD21106.1 - 0.0093 15.7 0.0 0.039 13.6 0.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF569) GreA_GreB_N PF03449.15 AMD21106.1 - 0.096 12.9 0.3 0.25 11.5 0.3 1.7 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Rogdi_lz PF10259.9 AMD21107.1 - 4.4e-57 193.6 4.5 5.4e-57 193.3 4.5 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein MIEAP PF16026.5 AMD21107.1 - 0.17 12.1 1.0 0.29 11.3 1.0 1.4 1 0 0 1 1 1 0 Mitochondria-eating protein PCRF PF03462.18 AMD21107.1 - 0.2 11.5 1.1 0.45 10.4 0.1 2.0 2 1 0 2 2 2 0 PCRF domain Orthopox_F14 PF06076.12 AMD21107.1 - 0.45 10.8 3.4 11 6.4 0.0 3.2 3 0 0 3 3 3 0 Orthopoxvirus F14 protein DASH_Spc19 PF08287.11 AMD21108.1 - 1.1e-34 119.5 11.2 1.6e-34 119.1 11.2 1.2 1 0 0 1 1 1 1 Spc19 GTP-bdg_M PF16360.5 AMD21108.1 - 0.0091 16.6 8.7 0.013 16.1 1.0 2.8 1 1 1 2 2 2 1 GTP-binding GTPase Middle Region DUF4407 PF14362.6 AMD21108.1 - 0.022 14.1 1.3 0.024 14.0 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMV_coat PF00721.21 AMD21108.1 - 0.073 12.9 0.1 0.098 12.5 0.1 1.2 1 0 0 1 1 1 0 Virus coat protein (TMV like) DUF4515 PF14988.6 AMD21108.1 - 0.13 12.0 10.0 0.71 9.7 10.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4515) PHM7_cyt PF14703.6 AMD21108.1 - 0.14 12.4 1.0 0.17 12.1 1.0 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF4140 PF13600.6 AMD21108.1 - 0.24 11.8 5.5 3.3 8.2 0.4 2.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Exonuc_VII_L PF02601.15 AMD21108.1 - 0.77 9.3 4.4 0.85 9.1 4.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Prefoldin_2 PF01920.20 AMD21108.1 - 1 9.4 10.3 0.76 9.8 0.9 2.5 3 0 0 3 3 3 0 Prefoldin subunit DASH_Dad2 PF08654.10 AMD21108.1 - 1.7 9.1 8.7 1.1 9.7 2.8 2.5 3 0 0 3 3 3 0 DASH complex subunit Dad2 APG6_N PF17675.1 AMD21108.1 - 4.5 7.8 15.3 9.2 6.8 12.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region FHA PF00498.26 AMD21109.1 - 5.3e-19 68.3 0.9 1.6e-17 63.6 0.1 3.0 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 AMD21109.1 - 3.2e-05 24.2 0.0 8.8e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF4407 PF14362.6 AMD21109.1 - 0.034 13.5 3.1 0.051 12.9 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC84 PF14968.6 AMD21109.1 - 1 8.9 8.2 1.5 8.3 8.2 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 YlqD PF11068.8 AMD21109.1 - 1.1 9.7 11.4 2.4 8.6 11.4 1.6 1 0 0 1 1 1 0 YlqD protein Nup54_57_C PF18570.1 AMD21109.1 - 1.7 8.3 5.3 7.2 6.3 3.3 2.4 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain LRS4 PF10422.9 AMD21109.1 - 5 6.6 15.8 10 5.6 15.8 1.5 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 BPL_LplA_LipB PF03099.19 AMD21110.1 - 3.8e-20 72.1 0.1 7.5e-20 71.2 0.1 1.5 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family SET PF00856.28 AMD21111.1 - 0.00042 20.7 0.0 0.00084 19.8 0.0 1.6 1 1 0 1 1 1 1 SET domain BNR_4 PF15892.5 AMD21111.1 - 0.026 13.9 0.2 0.04 13.3 0.2 1.2 1 0 0 1 1 1 0 BNR repeat-containing family member Synapsin PF02078.16 AMD21111.1 - 0.034 14.4 0.1 0.085 13.1 0.1 1.6 1 0 0 1 1 1 0 Synapsin, N-terminal domain TetR_C_4 PF08359.11 AMD21111.1 - 0.045 13.9 0.6 9.2 6.4 0.0 2.6 3 0 0 3 3 3 0 YsiA-like protein, C-terminal region ApbA_C PF08546.11 AMD21112.1 - 5.3e-16 58.9 0.0 9.8e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 AMD21112.1 - 0.0024 17.5 0.0 0.014 15.0 0.0 2.1 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA CoaE PF01121.20 AMD21113.1 - 5.3e-58 195.6 0.0 7.6e-58 195.1 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 AMD21113.1 - 0.00069 20.2 0.1 0.012 16.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain ALC PF17527.2 AMD21113.1 - 0.01 15.5 0.4 0.02 14.5 0.4 1.4 1 0 0 1 1 1 0 Phage ALC protein AAA_33 PF13671.6 AMD21113.1 - 0.01 16.0 0.0 0.029 14.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 AMD21113.1 - 0.018 15.5 0.1 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 AMD21113.1 - 0.022 14.5 0.1 0.047 13.4 0.0 1.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Cytidylate_kin2 PF13189.6 AMD21113.1 - 0.049 13.8 0.0 0.33 11.0 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_28 PF13521.6 AMD21113.1 - 0.099 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 AMD21113.1 - 0.12 12.5 0.0 0.43 10.7 0.0 1.8 2 0 0 2 2 2 0 Shikimate kinase P4Ha_N PF08336.11 AMD21114.1 - 0.052 13.6 1.3 0.12 12.4 1.3 1.6 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TetR_C_27 PF17935.1 AMD21114.1 - 0.14 12.3 1.1 8.6 6.5 0.1 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DEAD PF00270.29 AMD21115.1 - 2.3e-41 141.5 0.7 5.1e-41 140.3 0.2 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21115.1 - 4e-23 81.9 0.0 1.5e-22 80.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD21115.1 - 1.9e-06 28.0 0.0 6e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 AMD21115.1 - 0.056 13.2 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain FadA PF09403.10 AMD21115.1 - 4.2 7.9 6.3 1 9.9 0.1 3.1 5 0 0 5 5 5 0 Adhesion protein FadA PI3Ka PF00613.20 AMD21116.1 - 5.8e-65 218.2 3.1 9.7e-65 217.4 3.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 AMD21116.1 - 2.1e-49 168.6 0.0 1.1e-32 113.8 0.0 2.7 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 AMD21116.1 - 1.9e-24 86.1 1.0 2.9e-24 85.6 0.2 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 Closter_coat PF01785.17 AMD21116.1 - 0.022 14.0 0.1 0.059 12.6 0.1 1.7 1 0 0 1 1 1 0 Closterovirus coat protein RSN1_7TM PF02714.15 AMD21117.1 - 3.3e-82 275.9 23.1 3.3e-82 275.9 23.1 2.1 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AMD21117.1 - 2.2e-37 128.2 2.7 2.2e-37 128.2 2.7 2.5 2 1 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AMD21117.1 - 1.9e-31 109.7 0.0 4e-31 108.6 0.0 1.6 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF3810 PF12725.7 AMD21117.1 - 0.53 9.6 5.9 2.5 7.4 2.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) YMF19 PF02326.15 AMD21117.1 - 4.9 8.0 7.8 27 5.6 0.5 3.9 3 1 1 4 4 4 0 Plant ATP synthase F0 Arv1 PF04161.13 AMD21118.1 - 1.1e-60 205.5 10.3 1.5e-60 205.0 10.3 1.2 1 0 0 1 1 1 1 Arv1-like family zf-C3H2C3 PF17122.5 AMD21118.1 - 9.3 6.4 9.6 0.93 9.6 4.7 1.9 2 0 0 2 2 2 0 Zinc-finger zf_CCCH_4 PF18345.1 AMD21119.1 - 1.6e-06 27.9 8.1 3.4e-06 26.9 8.1 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 AMD21119.1 - 4.9e-06 26.3 3.9 8e-06 25.6 3.9 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 AMD21119.1 - 4.4e-05 23.2 2.8 8e-05 22.3 2.8 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 AMD21119.1 - 0.0011 19.7 0.4 0.0028 18.4 0.4 1.7 1 0 0 1 1 1 1 Torus domain Chlamy_scaf PF09675.10 AMD21119.1 - 0.054 13.9 0.3 0.16 12.3 0.1 1.9 2 0 0 2 2 2 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) zf-CCCH_2 PF14608.6 AMD21119.1 - 0.65 10.6 5.8 1.3 9.6 5.8 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 AMD21119.1 - 1.1 9.6 4.4 0.32 11.2 1.3 1.7 2 0 0 2 2 2 0 Zinc-finger containing family ATP_bind_1 PF03029.17 AMD21120.1 - 1.3e-85 287.1 0.0 1.5e-85 286.9 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 AMD21120.1 - 0.0025 17.4 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AMD21120.1 - 0.015 15.2 0.6 0.27 11.1 0.1 2.4 2 1 0 2 2 2 0 RsgA GTPase AAA_10 PF12846.7 AMD21120.1 - 0.02 13.8 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain MeaB PF03308.16 AMD21120.1 - 0.026 13.5 0.1 0.046 12.7 0.0 1.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 AMD21120.1 - 0.032 14.0 0.0 0.16 11.7 0.0 2.1 1 1 1 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 AMD21120.1 - 0.046 13.8 0.0 0.22 11.6 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 AMD21120.1 - 0.06 13.7 0.0 0.26 11.7 0.0 2.1 3 0 0 3 3 2 0 RNA helicase AAA_7 PF12775.7 AMD21120.1 - 0.089 12.3 0.0 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_19 PF13245.6 AMD21120.1 - 0.099 13.0 0.0 0.39 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AMD21120.1 - 0.1 13.0 0.0 0.13 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 AMD21120.1 - 0.11 13.1 0.0 0.23 12.0 0.0 1.6 2 0 0 2 2 2 0 ABC transporter AAA_18 PF13238.6 AMD21120.1 - 0.12 12.9 0.1 0.36 11.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 AMD21120.1 - 0.15 11.7 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 AMD21120.1 - 0.15 11.2 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain SIR2 PF02146.17 AMD21121.1 - 7.5e-32 110.7 0.0 1.3e-31 109.9 0.0 1.3 1 0 0 1 1 1 1 Sir2 family Zn-ribbon_8 PF09723.10 AMD21121.1 - 0.24 11.6 5.3 0.53 10.5 5.3 1.6 1 0 0 1 1 1 0 Zinc ribbon domain His_Me_b4a2 PF18275.1 AMD21121.1 - 1.1 9.4 4.7 2.6 8.2 4.7 1.6 1 0 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain TIP49 PF06068.13 AMD21122.1 - 1.2e-169 564.0 0.4 1.5e-169 563.8 0.4 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 AMD21122.1 - 1.1e-22 79.9 0.3 3.1e-22 78.5 0.2 1.9 2 0 0 2 2 1 1 TIP49 AAA-lid domain AAA PF00004.29 AMD21122.1 - 1e-08 35.6 0.9 6.5e-05 23.4 0.1 2.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AMD21122.1 - 1.1e-06 28.5 0.3 0.00053 19.8 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AMD21122.1 - 0.0014 18.8 0.1 0.0036 17.6 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD21122.1 - 0.0019 18.5 0.8 2.8 8.3 0.2 2.6 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 AMD21122.1 - 0.012 14.9 0.0 0.029 13.7 0.0 1.6 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_16 PF13191.6 AMD21122.1 - 0.018 15.4 0.1 0.11 12.9 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 AMD21122.1 - 0.025 13.9 0.1 3.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI CPT PF07931.12 AMD21122.1 - 0.037 13.9 0.0 0.098 12.5 0.0 1.8 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 AMD21122.1 - 0.042 13.1 0.1 0.13 11.5 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 AMD21122.1 - 0.055 13.2 0.0 7.4 6.2 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.14 AMD21122.1 - 0.12 12.3 0.3 2 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) UBA_2 PF08587.11 AMD21122.1 - 0.13 12.4 2.4 2.4 8.3 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin associated domain (UBA) Parvo_NS1 PF01057.17 AMD21122.1 - 0.16 11.0 0.0 0.4 9.7 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.17 AMD21122.1 - 0.2 11.4 0.5 2 8.1 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Sec1 PF00995.23 AMD21123.1 - 8.1e-120 401.7 9.7 9.4e-120 401.5 9.7 1.0 1 0 0 1 1 1 1 Sec1 family Cpn60_TCP1 PF00118.24 AMD21124.1 - 1.4e-160 535.2 1.9 1.6e-160 535.0 1.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mur_ligase_M PF08245.12 AMD21125.1 - 1.2e-11 45.0 0.6 4.8e-08 33.2 0.0 3.1 2 1 1 3 3 3 2 Mur ligase middle domain Mur_ligase_C PF02875.21 AMD21125.1 - 0.00046 20.4 0.0 0.001 19.3 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain RRM_1 PF00076.22 AMD21126.1 - 0.038 13.8 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TruD PF01142.18 AMD21127.1 - 6.8e-75 252.4 0.5 9.4e-68 228.9 0.0 3.1 1 1 1 2 2 2 2 tRNA pseudouridine synthase D (TruD) YhzD PF14120.6 AMD21127.1 - 0.0019 18.3 0.1 0.015 15.4 0.1 2.4 2 0 0 2 2 2 1 YhzD-like protein Post_transc_reg PF13797.6 AMD21127.1 - 0.016 15.1 0.1 0.26 11.2 0.0 2.8 2 1 1 3 3 3 0 Post-transcriptional regulator WD40 PF00400.32 AMD21128.1 - 9.5e-33 111.7 11.4 1e-06 29.4 0.5 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Nucleoporin_N PF08801.11 AMD21128.1 - 4.4e-06 25.7 3.6 2 7.1 0.1 5.2 1 1 4 5 5 5 4 Nup133 N terminal like ANAPC4_WD40 PF12894.7 AMD21128.1 - 1.6e-05 25.1 0.3 3 8.2 0.0 5.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD21128.1 - 0.01 14.5 2.6 13 4.3 0.1 3.9 1 1 2 4 4 4 0 Nucleoporin Nup120/160 MOZ_SAS PF01853.18 AMD21129.1 - 4e-82 274.2 0.3 5.7e-82 273.7 0.3 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.8 AMD21129.1 - 6.9e-22 77.1 0.0 1.5e-21 76.0 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-MYST PF17772.1 AMD21129.1 - 8.8e-21 73.3 0.3 2.8e-20 71.7 0.3 1.9 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 AMD21129.1 - 0.0073 16.7 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AMD21129.1 - 0.016 15.4 0.0 0.067 13.4 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family PTPA PF03095.15 AMD21130.1 - 4.9e-114 380.8 0.5 5.6e-114 380.7 0.5 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DAGAT PF03982.13 AMD21131.1 - 1.5e-81 273.6 2.9 8.1e-74 248.2 0.1 2.1 1 1 1 2 2 2 2 Diacylglycerol acyltransferase Pkinase PF00069.25 AMD21132.1 - 9e-79 264.6 0.0 1.3e-78 264.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21132.1 - 4.1e-37 127.9 0.0 6.8e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AMD21132.1 - 1.4e-24 86.2 2.0 1.2e-13 51.2 0.1 3.2 3 0 0 3 3 3 2 FHA domain Yop-YscD_cpl PF16697.5 AMD21132.1 - 6.4e-10 39.2 0.1 7.5e-08 32.6 0.0 2.7 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 AMD21132.1 - 5e-09 35.9 0.0 9.9e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD21132.1 - 7.4e-06 26.1 0.0 0.016 15.2 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 AMD21132.1 - 4.7e-05 22.9 0.0 8.4e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FHA_2 PF17913.1 AMD21132.1 - 0.00014 22.0 1.3 3.5 7.9 0.0 3.8 3 0 0 3 3 3 2 FHA domain RIO1 PF01163.22 AMD21132.1 - 0.0028 17.3 0.2 0.0065 16.1 0.0 1.6 2 0 0 2 2 2 1 RIO1 family Asp PF00026.23 AMD21133.1 - 2.2e-96 323.0 0.0 2.7e-96 322.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD21133.1 - 4.6e-13 49.8 0.3 7e-09 36.2 0.0 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 AMD21133.1 - 3.9e-06 26.7 0.0 0.00015 21.6 0.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 AMD21133.1 - 0.0017 18.9 0.0 0.036 14.7 0.0 2.8 3 1 0 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 AMD21133.1 - 0.19 12.3 0.0 2.6 8.6 0.0 2.8 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease Kinesin PF00225.23 AMD21134.1 - 5.1e-104 347.8 1.2 9.7e-104 346.9 1.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AMD21134.1 - 9.5e-29 100.3 0.6 2.6e-28 98.8 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Spc29 PF17082.5 AMD21134.1 - 0.0083 16.0 6.4 0.44 10.4 2.9 2.4 2 0 0 2 2 2 2 Spindle Pole Component 29 Raco_middle PF17651.1 AMD21134.1 - 0.086 12.5 2.5 0.15 11.7 1.1 2.0 2 0 0 2 2 2 0 RACo middle region PKcGMP_CC PF16808.5 AMD21134.1 - 0.65 9.9 10.8 1.4 8.8 0.4 3.2 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Mannosyl_trans3 PF11051.8 AMD21135.1 - 0.066 12.6 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Methyltransf_15 PF09445.10 AMD21136.1 - 1.6e-63 213.2 0.0 2e-63 212.9 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 AMD21136.1 - 6.2e-06 26.8 0.0 1.6e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MethyltransfD12 PF02086.15 AMD21136.1 - 7.6e-05 22.5 0.1 7.6e-05 22.5 0.1 1.6 2 0 0 2 2 2 1 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_31 PF13847.6 AMD21136.1 - 0.0001 22.1 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 AMD21136.1 - 0.00022 21.0 0.7 0.067 12.9 0.1 2.3 1 1 1 2 2 2 2 DNA methylase UPF0020 PF01170.18 AMD21136.1 - 0.00077 19.2 0.1 0.0028 17.4 0.1 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 tRNA_U5-meth_tr PF05958.11 AMD21136.1 - 0.007 15.4 0.1 0.01 14.9 0.1 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase CMAS PF02353.20 AMD21136.1 - 0.012 15.0 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 AMD21136.1 - 0.029 14.2 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 AMD21136.1 - 0.036 13.6 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.12 AMD21136.1 - 0.038 14.6 0.0 0.13 12.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 AMD21136.1 - 0.041 13.5 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Met_10 PF02475.16 AMD21136.1 - 0.048 13.4 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein N6_Mtase PF02384.16 AMD21136.1 - 0.054 12.8 0.0 0.13 11.5 0.0 1.6 1 1 0 1 1 1 0 N-6 DNA Methylase Abhydrolase_1 PF00561.20 AMD21138.1 - 7.7e-15 55.2 0.0 2.1e-14 53.8 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AMD21138.1 - 1.5e-12 47.3 0.0 3.2e-12 46.2 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1749 PF08538.10 AMD21138.1 - 0.0051 15.9 0.0 0.0085 15.2 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) DUF900 PF05990.12 AMD21138.1 - 0.061 12.8 0.0 0.18 11.3 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Transpos_assoc PF13963.6 AMD21139.1 - 0.088 13.1 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Transposase-associated domain tRNA-synt_1 PF00133.22 AMD21140.1 - 8.7e-43 146.5 0.0 3.7e-33 114.7 0.0 2.5 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AMD21140.1 - 2.1e-16 59.7 0.0 2.3e-09 36.5 0.0 3.4 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AMD21140.1 - 1.7e-12 47.5 0.0 4.1e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AMD21140.1 - 7.5e-07 28.8 0.6 1.4e-06 27.9 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain adh_short PF00106.25 AMD21141.1 - 2.3e-22 79.4 0.1 1.1e-17 64.1 0.1 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AMD21141.1 - 4.6e-11 42.7 0.0 9.3e-09 35.2 0.0 2.7 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD21141.1 - 0.0016 18.4 0.0 0.0033 17.4 0.0 1.6 1 1 0 1 1 1 1 KR domain DUF913 PF06025.12 AMD21142.1 - 0.00077 18.5 2.2 0.0012 17.9 0.9 1.9 2 1 0 2 2 2 1 Domain of Unknown Function (DUF913) RPN2_C PF18004.1 AMD21142.1 - 0.0036 17.2 8.4 0.0063 16.4 8.4 1.3 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain SDA1 PF05285.12 AMD21142.1 - 0.0058 16.1 8.2 0.0077 15.7 8.2 1.2 1 0 0 1 1 1 1 SDA1 CobT PF06213.12 AMD21142.1 - 0.023 14.1 10.2 0.037 13.4 10.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sigma70_ner PF04546.13 AMD21142.1 - 0.034 14.0 12.7 0.077 12.9 12.7 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region BUD22 PF09073.10 AMD21142.1 - 0.061 12.7 8.4 0.084 12.2 8.4 1.2 1 0 0 1 1 1 0 BUD22 Cucumopine_C PF18631.1 AMD21142.1 - 0.21 11.6 0.9 9.9 6.1 0.1 2.7 2 0 0 2 2 2 0 Cucumopine synthase C-terminal helical bundle domain NARP1 PF12569.8 AMD21142.1 - 0.21 10.4 7.6 0.49 9.2 7.6 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DNA_pol_phi PF04931.13 AMD21142.1 - 0.5 8.4 30.9 0.28 9.3 24.4 2.4 2 1 0 2 2 2 0 DNA polymerase phi CPSF100_C PF13299.6 AMD21142.1 - 0.56 10.4 3.6 1.1 9.5 3.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RXT2_N PF08595.11 AMD21142.1 - 0.89 9.6 9.9 0.96 9.5 8.2 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal TFB6 PF17110.5 AMD21142.1 - 1.2 8.8 11.0 4 7.2 9.3 2.4 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF4611 PF15387.6 AMD21142.1 - 2.4 8.5 15.2 14 6.0 13.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nop14 PF04147.12 AMD21142.1 - 2.7 6.1 21.1 1 7.5 18.5 1.5 2 0 0 2 2 2 0 Nop14-like family FAM176 PF14851.6 AMD21142.1 - 3.8 7.2 10.5 7.8 6.1 10.5 1.5 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 AMD21142.1 - 4.2 5.5 14.1 6.4 4.9 14.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid_p PF12226.8 AMD21142.1 - 5.2 6.1 16.2 8 5.5 16.2 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TRAP_alpha PF03896.16 AMD21142.1 - 5.3 6.2 9.3 8.5 5.5 9.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Merozoite_SPAM PF07133.11 AMD21142.1 - 5.4 7.0 29.9 13 5.7 29.9 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) STIMATE PF12400.8 AMD21143.1 - 3.2e-39 134.3 6.9 5.1e-39 133.7 6.9 1.3 1 0 0 1 1 1 1 STIMATE family STIMATE PF12400.8 AMD21144.1 - 2.3e-43 147.7 9.3 3.8e-43 147.0 8.7 1.6 2 0 0 2 2 2 1 STIMATE family DUF4271 PF14093.6 AMD21144.1 - 0.0015 18.5 3.0 0.0042 17.0 2.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4271) DUF2208 PF09973.9 AMD21144.1 - 6.8 6.2 6.4 18 4.8 5.6 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2208) HATPase_c PF02518.26 AMD21146.1 - 5.1e-09 36.6 0.1 1.2e-08 35.4 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AMD21146.1 - 6.1e-09 35.8 0.0 1.2e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 AMD21146.1 - 8.2e-08 32.1 0.0 5.4e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 AMD21146.1 - 0.001 18.7 0.0 0.0054 16.4 0.0 2.3 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain ANAPC5 PF12862.7 AMD21147.1 - 5.7e-18 64.8 3.5 7.2e-18 64.5 0.1 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 Clp1 PF06807.14 AMD21148.1 - 7e-29 100.6 0.0 1.1e-28 99.9 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 AMD21148.1 - 2.4e-28 99.2 0.0 3.6e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 AMD21148.1 - 5.8e-25 87.3 0.0 1.1e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_16 PF13191.6 AMD21148.1 - 0.00069 20.0 0.0 0.0012 19.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 AMD21148.1 - 0.0022 17.8 0.0 0.0033 17.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AMD21148.1 - 0.0084 16.6 0.1 0.018 15.5 0.1 1.5 1 0 0 1 1 1 1 ABC transporter PduV-EutP PF10662.9 AMD21148.1 - 0.047 13.4 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 AMD21148.1 - 0.051 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 AMD21148.1 - 0.061 12.8 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 AMD21148.1 - 0.11 12.7 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 AMD21148.1 - 0.12 12.2 0.0 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein Rhodanese PF00581.20 AMD21149.1 - 3.5e-16 59.6 0.0 4.4e-09 36.8 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Atg29_N PF18388.1 AMD21150.1 - 2.7e-15 55.9 0.7 4.2e-15 55.3 0.7 1.3 1 0 0 1 1 1 1 Atg29 N-terminal domain Myb_DNA-bind_6 PF13921.6 AMD21150.1 - 0.0015 18.8 0.9 0.0027 17.9 0.9 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain GAIN_A PF18619.1 AMD21150.1 - 0.044 14.0 0.2 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A DUF3939 PF13075.6 AMD21150.1 - 0.085 12.9 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) DNA_pol_B PF00136.21 AMD21151.1 - 3.5e-99 332.6 0.0 5.5e-99 331.9 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AMD21151.1 - 1.1e-15 57.7 0.1 3.6e-07 29.6 0.1 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 AMD21151.1 - 6.4e-09 36.1 8.0 1.3e-08 35.1 8.0 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DZR PF12773.7 AMD21151.1 - 0.37 10.9 2.8 0.83 9.7 2.8 1.5 1 0 0 1 1 1 0 Double zinc ribbon Tma16 PF11176.8 AMD21152.1 - 1.9e-49 167.3 3.5 2.3e-49 167.1 3.5 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 FlxA PF14282.6 AMD21153.1 - 1.3 9.0 9.5 1.2 9.2 0.8 2.9 2 1 1 3 3 3 0 FlxA-like protein Acetyltransf_1 PF00583.25 AMD21154.1 - 1.2e-10 41.7 0.0 1.5e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AMD21154.1 - 2.6e-09 37.4 0.0 3.5e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AMD21154.1 - 1.1e-08 35.0 0.0 1.5e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AMD21154.1 - 0.002 18.0 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 AMD21154.1 - 0.01 15.4 0.2 0.011 15.3 0.2 1.2 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_4 PF13420.7 AMD21154.1 - 0.028 14.6 0.0 0.043 13.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Slx4 PF09494.10 AMD21154.1 - 0.12 12.4 0.0 1.5 8.8 0.1 2.3 1 1 1 2 2 2 0 Slx4 endonuclease DnaJ PF00226.31 AMD21155.1 - 5.2e-14 52.1 0.9 1.3e-13 50.9 0.9 1.7 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 AMD21155.1 - 0.001 18.3 0.0 0.0019 17.4 0.0 1.4 1 0 0 1 1 1 1 Sec63 Brl domain RRM_9 PF18444.1 AMD21156.1 - 2.6e-29 100.8 0.2 6.4e-29 99.6 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif TAP_C PF03943.13 AMD21156.1 - 1.2e-12 47.3 1.1 2.9e-12 46.0 0.1 2.3 2 0 0 2 2 2 1 TAP C-terminal domain LRR_9 PF14580.6 AMD21156.1 - 2.3e-08 33.7 1.1 6.2e-08 32.3 1.1 1.7 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 AMD21156.1 - 6.8e-06 26.3 15.9 0.00047 20.5 5.9 3.1 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) HATPase_c_5 PF14501.6 AMD21156.1 - 0.082 12.8 0.8 0.26 11.2 0.0 2.2 3 0 0 3 3 3 0 GHKL domain LRR_8 PF13855.6 AMD21156.1 - 0.34 10.7 8.2 0.067 13.0 3.1 2.5 2 0 0 2 2 2 0 Leucine rich repeat Cyt-b5 PF00173.28 AMD21158.1 - 3.4e-14 52.7 0.0 4.7e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFR_dimer PF04253.15 AMD21159.1 - 2.4e-29 101.9 0.0 5.5e-29 100.7 0.0 1.7 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PIGA PF08288.12 AMD21160.1 - 1.2e-45 154.0 2.8 4.8e-45 152.1 2.8 2.1 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 AMD21160.1 - 5.2e-31 107.9 4.0 1.9e-30 106.1 0.9 2.2 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 AMD21160.1 - 8.1e-26 90.6 0.0 1.3e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AMD21160.1 - 9.8e-22 77.8 0.1 2.3e-21 76.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AMD21160.1 - 7.2e-13 49.3 0.0 7.7e-12 45.9 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 AMD21160.1 - 0.0095 16.3 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 AMD21160.1 - 0.031 14.3 0.5 0.11 12.5 0.5 1.8 2 0 0 2 2 2 0 Glycosyl transferase 4-like Glyco_transf_5 PF08323.11 AMD21160.1 - 0.069 12.8 0.1 0.3 10.8 0.1 2.0 1 1 1 2 2 2 0 Starch synthase catalytic domain Amido_AtzD_TrzD PF09663.10 AMD21160.1 - 0.089 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) CAP_GLY PF01302.25 AMD21161.1 - 2.3e-20 72.4 1.3 3.9e-20 71.6 1.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain EF-hand_1 PF00036.32 AMD21162.1 - 8.7e-28 93.8 17.2 1.5e-08 33.6 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AMD21162.1 - 3.7e-27 94.6 13.2 1.3e-15 57.6 1.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AMD21162.1 - 1.1e-21 74.8 14.1 9.8e-08 31.3 0.3 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 AMD21162.1 - 1.3e-19 69.8 15.3 1.9e-10 40.4 0.7 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 AMD21162.1 - 3.6e-13 48.4 12.2 3e-05 23.3 0.1 4.3 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.7 AMD21162.1 - 4.2e-09 36.3 4.6 1.6e-05 24.8 0.4 2.4 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 AMD21162.1 - 1.2e-07 31.9 1.8 0.00012 22.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 AMD21162.1 - 0.00066 20.0 0.9 0.13 12.6 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 AMD21162.1 - 0.0024 18.2 1.1 0.28 11.5 0.1 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region SUB1_ProdP9 PF18213.1 AMD21162.1 - 0.018 14.9 0.3 0.036 13.9 0.3 1.5 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 Caleosin PF05042.13 AMD21162.1 - 0.024 14.6 1.3 1.9 8.4 0.1 3.2 1 1 3 4 4 4 0 Caleosin related protein MgtE_N PF03448.17 AMD21162.1 - 0.035 14.7 1.8 0.11 13.1 0.1 2.4 3 0 0 3 3 3 0 MgtE intracellular N domain DUF1296 PF06972.11 AMD21162.1 - 0.057 13.6 0.5 2.6 8.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) PhetRS_B1 PF18262.1 AMD21162.1 - 0.12 12.7 0.5 0.12 12.7 0.5 2.1 2 1 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain Dockerin_1 PF00404.18 AMD21162.1 - 0.52 10.5 5.7 3.4 7.9 0.1 2.7 3 0 0 3 3 3 0 Dockerin type I domain FG-GAP PF01839.23 AMD21162.1 - 1.9 8.7 4.2 4 7.7 0.1 2.5 2 0 0 2 2 2 0 FG-GAP repeat AAA PF00004.29 AMD21164.1 - 1.2e-42 145.5 0.0 2.2e-42 144.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD21164.1 - 3.7e-09 36.2 0.2 7.8e-09 35.2 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AMD21164.1 - 1.7e-07 31.8 0.1 8.2e-05 23.0 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 AMD21164.1 - 9.7e-07 28.9 0.1 2.9e-05 24.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_ID_OB PF16450.5 AMD21164.1 - 4.1e-06 26.6 0.3 4.1e-06 26.6 0.3 2.1 3 0 0 3 3 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AMD21164.1 - 3.3e-05 24.1 0.0 9.8e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AMD21164.1 - 6.9e-05 22.6 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 AMD21164.1 - 0.00017 21.6 0.0 0.0003 20.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 AMD21164.1 - 0.0018 18.6 0.2 0.033 14.5 0.1 2.4 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 AMD21164.1 - 0.0022 18.4 0.0 0.0048 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 AMD21164.1 - 0.0023 17.2 0.0 0.0045 16.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 AMD21164.1 - 0.0049 16.3 0.1 0.011 15.2 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AMD21164.1 - 0.0074 16.8 0.0 0.028 15.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AMD21164.1 - 0.0086 16.2 0.0 0.023 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AMD21164.1 - 0.013 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 AMD21164.1 - 0.014 15.1 0.1 0.036 13.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain Fib_alpha PF08702.10 AMD21164.1 - 0.016 15.4 1.0 0.04 14.1 1.0 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family AAA_28 PF13521.6 AMD21164.1 - 0.017 15.4 0.2 0.064 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 AMD21164.1 - 0.041 13.2 1.4 0.11 11.8 0.0 2.4 3 0 0 3 3 3 0 KaiC AAA_11 PF13086.6 AMD21164.1 - 0.052 13.3 2.6 0.97 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 AMD21164.1 - 0.057 13.5 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AMD21164.1 - 0.068 12.7 0.0 0.16 11.5 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 AMD21164.1 - 0.07 12.6 0.3 0.14 11.6 0.3 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 AMD21164.1 - 0.075 12.6 0.8 0.18 11.4 0.1 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 AMD21164.1 - 0.079 12.0 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 AMD21164.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AMD21164.1 - 0.12 12.1 0.2 0.61 9.8 0.0 2.2 2 1 0 2 2 2 0 Sigma-54 interaction domain DUF4798 PF16055.5 AMD21164.1 - 0.15 12.3 1.7 0.29 11.4 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) NACHT PF05729.12 AMD21164.1 - 0.15 12.0 0.1 0.49 10.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 AMD21164.1 - 0.47 10.9 6.4 8.1 6.9 2.4 2.5 2 1 0 2 2 2 0 AAA domain DUF1079 PF06435.11 AMD21164.1 - 4.5 7.6 6.4 0.39 11.0 1.1 2.1 2 0 0 2 2 1 0 Repeat of unknown function (DUF1079) Anp1 PF03452.14 AMD21165.1 - 9.3e-115 382.6 0.0 1.2e-114 382.2 0.0 1.1 1 0 0 1 1 1 1 Anp1 GldH_lipo PF14109.6 AMD21165.1 - 0.049 14.4 0.0 0.094 13.5 0.0 1.4 1 0 0 1 1 1 0 GldH lipoprotein UBA PF00627.31 AMD21166.1 - 2.8e-26 91.0 4.4 3.7e-14 52.3 0.7 2.5 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 AMD21166.1 - 1.6e-15 56.6 0.6 2.8e-15 55.8 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.11 AMD21166.1 - 1.9e-11 43.5 0.5 3.3e-11 42.7 0.5 1.4 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.8 AMD21166.1 - 8.4e-07 28.7 0.8 1.7e-06 27.7 0.8 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like CUE PF02845.16 AMD21166.1 - 0.00012 21.7 0.7 4.3 7.1 0.0 5.1 4 2 2 6 6 6 2 CUE domain DUF2407 PF10302.9 AMD21166.1 - 0.00013 22.4 0.0 0.00035 21.1 0.0 1.8 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 AMD21166.1 - 0.0002 21.4 0.1 0.00042 20.4 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 AMD21166.1 - 0.0011 19.2 0.5 0.002 18.5 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain DUF1421 PF07223.11 AMD21166.1 - 0.14 12.0 0.1 21 5.1 0.0 2.4 2 0 0 2 2 2 0 UBA-like domain (DUF1421) Cytochrom_C PF00034.21 AMD21167.1 - 1.2e-08 36.0 0.2 2e-08 35.3 0.2 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 AMD21167.1 - 8.3e-08 32.5 2.1 1.1e-06 28.8 2.1 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III zf-LSD1 PF06943.12 AMD21167.1 - 0.099 12.5 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 LSD1 zinc finger NAD_kinase PF01513.21 AMD21168.1 - 5.6e-87 291.6 0.0 7.3e-87 291.3 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 AMD21168.1 - 0.015 14.9 0.0 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF4100 PF13352.6 AMD21168.1 - 0.082 12.7 3.2 0.2 11.4 3.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) GDA1_CD39 PF01150.17 AMD21169.1 - 3.4e-119 398.3 0.0 4.1e-119 398.0 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Isy1 PF06246.12 AMD21170.1 - 6.6e-58 196.3 13.4 1.6e-56 191.7 13.4 2.0 1 1 0 1 1 1 1 Isy1-like splicing family fn3 PF00041.21 AMD21171.1 - 0.0028 18.0 0.0 0.015 15.6 0.0 2.3 1 1 0 1 1 1 1 Fibronectin type III domain DUF1664 PF07889.12 AMD21171.1 - 0.029 14.4 12.4 0.21 11.6 5.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 AMD21171.1 - 0.83 9.6 19.1 4 7.5 12.0 3.4 2 1 1 3 3 3 0 Prefoldin subunit DUF4559 PF15112.6 AMD21171.1 - 1.1 8.8 13.2 2 8.0 13.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Baculo_PEP_C PF04513.12 AMD21171.1 - 1.5 8.9 11.4 1.4 9.0 5.6 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 AMD21171.1 - 1.9 7.8 7.1 3.3 7.0 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3782 PF12644.7 AMD21171.1 - 2.1 8.5 4.4 1.2 9.4 0.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3782) Seryl_tRNA_N PF02403.22 AMD21171.1 - 3.6 7.9 18.2 11 6.3 12.2 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BST2 PF16716.5 AMD21171.1 - 5.3 7.7 12.3 61 4.3 7.8 3.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Snapin_Pallidin PF14712.6 AMD21171.1 - 6.3 7.3 18.5 3.3 8.2 1.2 3.0 1 1 1 2 2 2 0 Snapin/Pallidin DUF2115 PF09888.9 AMD21171.1 - 8.5 6.9 8.1 3.1 8.3 4.5 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) DUF4200 PF13863.6 AMD21171.1 - 9.1 6.7 17.6 5.1 7.5 14.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) LMBR1 PF04791.16 AMD21171.1 - 9.6 5.0 10.2 22 3.8 10.2 1.6 1 0 0 1 1 1 0 LMBR1-like membrane protein YL1_C PF08265.11 AMD21172.1 - 7.2e-14 51.3 0.6 3.3e-12 45.9 0.1 2.5 3 0 0 3 3 3 2 YL1 nuclear protein C-terminal domain Beta_elim_lyase PF01212.21 AMD21173.1 - 1.5e-79 267.4 0.0 1.9e-79 267.0 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Sedlin_N PF04628.13 AMD21174.1 - 1.9e-09 37.7 0.0 2.3e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF676 PF05057.14 AMD21175.1 - 7.6e-42 143.3 0.1 1.2e-41 142.6 0.1 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AMD21175.1 - 6.4e-08 32.7 0.4 2e-07 31.1 0.0 1.8 2 0 0 2 2 2 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 AMD21175.1 - 0.0002 22.0 0.0 0.00029 21.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD21175.1 - 0.00083 18.7 0.1 0.016 14.5 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 AMD21175.1 - 0.0023 17.7 0.1 0.0041 16.9 0.1 1.3 1 0 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 AMD21175.1 - 0.024 14.0 0.1 1 8.6 0.0 2.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Lipase_2 PF01674.18 AMD21175.1 - 0.027 14.0 0.1 0.061 12.8 0.1 1.6 1 0 0 1 1 1 0 Lipase (class 2) Pox_F16 PF04708.12 AMD21175.1 - 0.045 13.2 0.1 0.1 12.0 0.0 1.6 2 0 0 2 2 2 0 Poxvirus F16 protein Lipase_3 PF01764.25 AMD21175.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_1 PF00561.20 AMD21175.1 - 0.25 11.0 1.0 1.1 8.9 0.1 2.4 3 0 0 3 3 3 0 alpha/beta hydrolase fold Zn_clus PF00172.18 AMD21176.1 - 7.6e-07 29.2 12.9 1.3e-06 28.4 12.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ctr PF04145.15 AMD21177.1 - 7.5e-20 72.1 12.8 1e-12 48.9 6.7 2.1 1 1 1 2 2 2 2 Ctr copper transporter family Enolase_C PF00113.22 AMD21178.1 - 2.3e-151 503.1 0.0 3.1e-151 502.7 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 AMD21178.1 - 1.5e-59 199.9 0.2 2.6e-59 199.1 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 AMD21178.1 - 7.9e-06 25.6 0.1 1.5e-05 24.7 0.1 1.5 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 AMD21178.1 - 0.028 13.6 0.9 0.061 12.5 0.1 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus GCP_N_terminal PF17681.1 AMD21179.1 - 1.4e-44 153.0 0.4 8.4e-44 150.4 0.1 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 AMD21179.1 - 2.5e-22 79.7 2.3 5.5e-22 78.6 2.3 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF1819 PF08849.11 AMD21179.1 - 0.07 12.9 0.5 0.18 11.6 0.1 1.8 2 0 0 2 2 2 0 Putative inner membrane protein (DUF1819) Proteasome PF00227.26 AMD21180.1 - 8.5e-53 178.7 0.0 1.1e-52 178.3 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AMD21180.1 - 2.9e-12 46.0 0.0 5.3e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Bromodomain PF00439.25 AMD21181.1 - 8.8e-26 89.8 1.8 2e-25 88.6 1.8 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 AMD21181.1 - 7.9e-09 35.8 0.0 1.7e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AMD21181.1 - 4.7e-06 26.6 0.1 9.8e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AMD21181.1 - 0.00053 20.4 0.1 0.00098 19.5 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DNA_pol_phi PF04931.13 AMD21181.1 - 0.31 9.1 25.1 0.4 8.7 25.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi PNISR PF15996.5 AMD21181.1 - 0.71 10.1 9.8 0.99 9.6 9.8 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR RRN3 PF05327.11 AMD21181.1 - 3.5 6.1 16.4 5.4 5.4 16.4 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 AMD21181.1 - 3.7 5.6 25.5 5.1 5.2 25.5 1.1 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 AMD21181.1 - 4.6 4.9 10.5 6.2 4.5 10.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 AMD21181.1 - 4.9 5.3 17.9 6.6 4.9 17.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 AMD21181.1 - 8.6 6.6 14.8 15 5.8 14.8 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2457 PF10446.9 AMD21181.1 - 8.6 5.4 25.3 12 4.9 25.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) ThiF PF00899.21 AMD21182.1 - 8.5e-45 153.0 0.0 1.3e-44 152.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 AMD21182.1 - 4.7e-42 144.7 4.2 3.7e-31 108.9 1.8 2.2 2 0 0 2 2 2 2 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus 2-Hacid_dh_C PF02826.19 AMD21182.1 - 0.0041 16.5 0.0 0.17 11.2 0.0 2.7 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AMD21182.1 - 0.005 16.9 0.0 0.014 15.4 0.0 1.7 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase NMD3 PF04981.13 AMD21183.1 - 1.5e-82 276.7 2.2 2.8e-82 275.9 2.2 1.4 1 0 0 1 1 1 1 NMD3 family HypA PF01155.19 AMD21183.1 - 0.054 13.5 5.3 2.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA IpaC_SipC PF09599.10 AMD21183.1 - 0.12 11.9 0.4 0.2 11.2 0.4 1.3 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) DZR PF12773.7 AMD21183.1 - 2.3 8.3 6.1 39 4.4 6.1 2.6 1 1 0 1 1 1 0 Double zinc ribbon NOP19 PF10863.8 AMD21184.1 - 1.3e-51 174.1 9.0 1.9e-51 173.7 9.0 1.1 1 0 0 1 1 1 1 Nucleolar protein 19 DEAD PF00270.29 AMD21185.1 - 3e-44 150.9 0.1 3.6e-43 147.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21185.1 - 2.7e-32 111.4 0.1 1.2e-31 109.3 0.1 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD21185.1 - 0.00031 20.8 0.0 0.002 18.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AMD21185.1 - 0.013 14.8 0.0 0.024 13.9 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase GTP1_OBG PF01018.22 AMD21186.1 - 2.7e-37 127.7 1.4 9.2e-28 96.8 1.7 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 AMD21186.1 - 2e-22 79.4 0.1 3.5e-22 78.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD21186.1 - 1.4e-11 44.2 0.1 2.5e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 AMD21186.1 - 5.8e-11 42.2 0.1 1.5e-10 40.8 0.1 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 AMD21186.1 - 0.0046 16.6 0.0 0.0093 15.6 0.0 1.6 1 1 0 1 1 1 1 Ras family MeaB PF03308.16 AMD21186.1 - 0.0067 15.4 0.0 0.74 8.7 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 AMD21186.1 - 0.032 13.8 0.3 0.85 9.1 0.1 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AMD21186.1 - 0.041 13.9 0.2 4.4 7.3 0.1 2.4 1 1 1 2 2 2 0 Dynamin family SRPRB PF09439.10 AMD21186.1 - 0.042 13.3 0.0 0.11 11.9 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AIG1 PF04548.16 AMD21186.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 AIG1 family THP2 PF09432.10 AMD21187.1 - 2.1e-39 134.5 1.0 2.1e-39 134.5 1.0 2.0 2 0 0 2 2 2 1 Tho complex subunit THP2 Focal_AT PF03623.13 AMD21187.1 - 0.052 13.5 0.5 6.3 6.8 0.1 2.7 3 0 0 3 3 3 0 Focal adhesion targeting region ANAPC8 PF04049.13 AMD21188.1 - 4.7e-37 127.2 4.7 9e-37 126.2 4.7 1.4 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 AMD21188.1 - 7.4e-28 95.2 15.8 4.3e-05 23.1 0.1 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 AMD21188.1 - 8.1e-23 78.7 19.1 0.00015 21.7 0.0 7.9 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 AMD21188.1 - 3.7e-20 70.4 21.2 0.00031 20.6 0.0 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 AMD21188.1 - 1.2e-15 56.8 1.9 0.0049 17.6 0.0 5.6 5 1 1 6 6 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 AMD21188.1 - 6.7e-13 48.1 3.8 1.8e-07 30.7 0.0 5.3 3 3 3 6 6 6 2 TPR repeat TPR_16 PF13432.6 AMD21188.1 - 7.2e-09 36.2 4.6 5.2e-06 27.0 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 AMD21188.1 - 3.1e-08 33.8 11.2 0.034 14.4 0.1 5.6 3 1 3 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD21188.1 - 8.2e-08 32.4 22.0 0.015 15.5 1.8 5.4 4 1 1 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 AMD21188.1 - 1.3e-07 32.1 4.1 0.0029 18.1 0.3 5.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 AMD21188.1 - 1.3e-07 31.5 13.8 0.0096 16.2 0.1 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 AMD21188.1 - 4.6e-07 29.4 3.6 0.094 12.8 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat ChAPs PF09295.10 AMD21188.1 - 6.1e-07 28.8 0.2 1.9e-06 27.2 0.1 1.8 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_9 PF13371.6 AMD21188.1 - 1.6e-05 24.9 0.4 0.47 10.6 0.6 3.7 2 1 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 AMD21188.1 - 2.4e-05 24.8 1.0 0.00032 21.2 0.6 2.7 2 1 1 3 3 3 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 AMD21188.1 - 4.5e-05 22.8 4.4 0.0004 19.7 0.5 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 AMD21188.1 - 0.00012 22.5 12.6 5.7 7.8 0.0 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat Sel1 PF08238.12 AMD21188.1 - 0.00086 19.9 5.7 20 6.1 0.4 5.0 5 0 0 5 5 5 0 Sel1 repeat HTH_Tnp_Mu_2 PF09039.11 AMD21188.1 - 0.12 12.5 0.1 0.34 11.0 0.1 1.8 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain PROCN PF08083.11 AMD21189.1 - 1.1e-221 735.7 12.0 1.8e-221 735.1 12.0 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 AMD21189.1 - 3.9e-120 399.7 0.9 6.7e-120 398.9 0.9 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 AMD21189.1 - 1.1e-83 278.9 1.2 1.1e-83 278.9 1.2 1.9 2 0 0 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 AMD21189.1 - 3.5e-80 267.3 2.2 7.9e-80 266.1 2.2 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 AMD21189.1 - 1e-69 232.8 0.0 2.4e-69 231.6 0.0 1.7 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 AMD21189.1 - 3.8e-46 156.0 0.0 8.3e-46 154.9 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 AMD21189.1 - 1.1e-44 150.7 0.1 2.8e-44 149.4 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 zf-C3H1 PF10650.9 AMD21190.1 - 0.0072 16.0 0.1 0.014 15.1 0.1 1.5 1 0 0 1 1 1 1 Putative zinc-finger domain CRT10 PF08728.10 AMD21191.1 - 1.2e-168 562.5 4.8 3e-168 561.2 4.8 1.6 1 1 0 1 1 1 1 CRT10 MFS_1 PF07690.16 AMD21192.1 - 5.8e-37 127.4 27.3 8.2e-37 126.9 27.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Raptor_N PF14538.6 AMD21193.1 - 5.8e-68 227.5 0.0 1.2e-67 226.4 0.0 1.6 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 AMD21193.1 - 0.00023 21.2 1.9 0.085 13.2 0.0 4.7 5 0 0 5 5 5 1 HEAT repeat BBS2_Mid PF14783.6 AMD21193.1 - 0.00042 20.3 2.0 0.0092 16.0 0.1 3.6 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 AMD21193.1 - 0.00092 20.0 8.5 5.9 7.9 0.0 6.4 7 0 0 7 7 7 1 WD domain, G-beta repeat Cnd1 PF12717.7 AMD21193.1 - 0.0073 16.4 0.1 0.23 11.5 0.1 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD21193.1 - 0.024 15.0 0.0 0.25 11.7 0.0 2.6 3 0 0 3 3 3 0 HEAT repeats Elong_Iki1 PF10483.9 AMD21194.1 - 1.2e-71 241.6 2.9 1.4e-71 241.4 2.9 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Gpi16 PF04113.14 AMD21195.1 - 2.1e-187 624.0 0.0 2.6e-187 623.7 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component HEAT PF02985.22 AMD21196.1 - 9e-14 50.4 9.2 0.024 14.9 0.0 9.4 11 0 0 11 11 9 3 HEAT repeat HEAT_EZ PF13513.6 AMD21196.1 - 1e-11 45.0 0.0 0.53 10.9 0.0 7.6 8 0 0 8 8 7 2 HEAT-like repeat HEAT_2 PF13646.6 AMD21196.1 - 4.7e-10 39.7 0.4 0.74 10.2 0.0 7.5 4 3 4 8 8 8 1 HEAT repeats Cnd1 PF12717.7 AMD21196.1 - 4.4e-08 33.3 1.1 0.39 10.8 0.0 6.3 5 2 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AMD21196.1 - 6.4e-08 33.1 0.0 0.0091 16.6 0.0 4.5 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 AMD21196.1 - 0.00028 20.6 0.1 1 8.9 0.0 3.1 2 0 0 2 2 2 2 NUC173 domain MMS19_C PF12460.8 AMD21196.1 - 0.00092 18.4 0.2 2.2 7.3 0.5 3.7 3 1 0 3 3 3 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 AMD21196.1 - 0.0026 17.4 0.3 7.4 6.1 0.0 3.9 3 2 0 3 3 3 2 CLASP N terminal Adaptin_N PF01602.20 AMD21196.1 - 0.0068 15.0 1.1 1.1 7.7 1.1 3.2 1 1 0 1 1 1 1 Adaptin N terminal region DUF3385 PF11865.8 AMD21196.1 - 0.012 15.5 9.0 0.4 10.6 0.1 4.9 5 1 0 5 5 5 0 Domain of unknown function (DUF3385) DUF4042 PF13251.6 AMD21196.1 - 0.021 14.6 0.2 14 5.3 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4042) Dopey_N PF04118.14 AMD21196.1 - 0.048 12.8 0.4 24 3.9 0.0 4.6 4 2 2 7 7 7 0 Dopey, N-terminal VHS PF00790.19 AMD21196.1 - 0.055 13.3 0.1 15 5.4 0.0 3.4 3 0 0 3 3 3 0 VHS domain UME PF08064.13 AMD21196.1 - 0.089 12.7 0.2 10 6.1 0.0 3.8 5 1 0 5 5 5 0 UME (NUC010) domain Adaptin_N PF01602.20 AMD21197.1 - 1.4e-96 324.2 10.1 1.7e-96 323.9 10.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AMD21197.1 - 5.6e-15 55.8 11.0 6.8e-13 49.0 0.5 4.7 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD21197.1 - 4.6e-10 39.7 0.8 2.8e-07 30.8 0.1 4.5 4 1 0 4 4 4 1 HEAT repeats HEAT PF02985.22 AMD21197.1 - 5.4e-07 29.3 3.5 0.011 16.0 0.0 5.9 6 0 0 6 6 6 1 HEAT repeat Cohesin_HEAT PF12765.7 AMD21197.1 - 0.00022 21.5 0.3 0.42 11.0 0.0 3.2 2 0 0 2 2 2 2 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.6 AMD21197.1 - 0.0022 18.5 1.9 7.4 7.2 0.0 4.1 4 1 0 4 4 4 2 HEAT-like repeat RasGEF_N_2 PF14663.6 AMD21197.1 - 0.032 14.6 1.6 12 6.3 0.0 4.2 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain NOA36 PF06524.12 AMD21197.1 - 4.1 6.6 11.4 5.8 6.1 11.4 1.2 1 0 0 1 1 1 0 NOA36 protein Ssl1 PF04056.14 AMD21198.1 - 7.4e-87 290.2 0.0 1.1e-86 289.6 0.0 1.3 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 AMD21198.1 - 1.4e-25 89.3 12.4 1.4e-25 89.3 12.4 2.7 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 AMD21198.1 - 9.1e-17 61.7 0.0 2e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 AMD21198.1 - 2.5e-07 31.1 0.0 5.8e-07 29.9 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain DNA_pol_phi PF04931.13 AMD21198.1 - 0.14 10.3 3.5 0.19 9.8 3.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 AMD21198.1 - 0.33 11.3 10.1 0.86 10.0 10.1 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 AMD21198.1 - 3.3 5.7 4.7 4.8 5.1 4.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DZR PF12773.7 AMD21198.1 - 5.9 7.0 25.2 0.81 9.8 6.9 3.3 2 1 0 2 2 2 0 Double zinc ribbon Glyco_hydro_92 PF07971.12 AMD21199.1 - 2.4e-106 356.4 5.1 3.5e-106 355.9 5.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 AMD21199.1 - 3.7e-39 135.1 0.9 6.2e-39 134.3 0.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Bac_rhamnosid6H PF17389.2 AMD21199.1 - 0.036 13.3 0.3 0.058 12.7 0.3 1.2 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain CMS1 PF14617.6 AMD21200.1 - 2.1e-10 40.3 17.6 3.1e-05 23.5 9.8 3.0 1 1 0 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit TINF2_N PF14973.6 AMD21200.1 - 0.7 10.2 5.2 3.1 8.1 1.0 2.3 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus Adaptin_N PF01602.20 AMD21201.1 - 1.2e-51 175.9 14.7 1.5e-51 175.6 14.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AMD21201.1 - 4.2e-06 26.9 8.8 0.00018 21.6 0.3 4.1 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD21201.1 - 3.2e-05 24.2 0.1 2 8.8 0.0 3.7 2 1 0 3 3 3 2 HEAT repeats S_100 PF01023.19 AMD21201.1 - 0.031 14.0 0.0 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain Response_reg PF00072.24 AMD21202.1 - 1.2e-19 70.5 0.0 7.9e-13 48.6 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain PIN_12 PF16289.5 AMD21202.1 - 0.14 12.6 0.1 0.14 12.6 0.1 1.7 2 0 0 2 2 2 0 PIN domain AMIN PF11741.8 AMD21202.1 - 0.18 11.9 0.6 0.62 10.2 0.1 2.1 2 0 0 2 2 2 0 AMIN domain SMC_Nse1 PF07574.13 AMD21203.1 - 2.7e-45 154.7 0.1 3.4e-45 154.3 0.1 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 AMD21203.1 - 5.7e-11 42.6 8.5 1.1e-10 41.6 8.5 1.5 1 0 0 1 1 1 1 RING-like domain LOH1CR12 PF10158.9 AMD21203.1 - 0.087 12.8 0.6 1.6 8.7 0.0 2.5 3 0 0 3 3 3 0 Tumour suppressor protein Pam16 PF03656.13 AMD21204.1 - 0.00057 19.9 0.0 0.00074 19.5 0.0 1.2 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 AMD21204.1 - 0.0019 18.3 0.1 0.0054 16.8 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain Ribosomal_L24e PF01246.20 AMD21205.1 - 3.7e-33 113.6 3.8 9.1e-33 112.3 3.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e Ribosomal_L28e PF01778.17 AMD21207.1 - 2.1e-39 134.8 2.8 2.1e-39 134.8 2.8 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 AMD21207.1 - 1e-29 103.1 15.0 1e-29 103.1 15.0 2.8 3 1 0 3 3 3 1 Mak16 protein C-terminal region BUD22 PF09073.10 AMD21207.1 - 4.3e-05 23.0 18.8 5.4e-05 22.7 18.8 1.1 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 AMD21207.1 - 0.04 13.7 0.6 0.066 12.9 0.6 1.5 1 0 0 1 1 1 0 Conserved carboxylase domain Ribosomal_L24e PF01246.20 AMD21207.1 - 0.15 12.3 0.1 0.15 12.3 0.1 2.0 2 0 0 2 2 2 0 Ribosomal protein L24e MFMR_assoc PF16596.5 AMD21207.1 - 0.4 11.2 5.0 0.66 10.4 5.0 1.3 1 0 0 1 1 1 0 Disordered region downstream of MFMR CDC45 PF02724.14 AMD21207.1 - 4.5 5.4 23.4 7.3 4.7 23.4 1.3 1 0 0 1 1 1 0 CDC45-like protein PhoLip_ATPase_C PF16212.5 AMD21208.1 - 1.9e-84 283.3 27.7 1.9e-84 283.3 27.7 2.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AMD21208.1 - 6.7e-25 86.6 4.3 2.3e-24 84.9 4.3 2.0 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 AMD21208.1 - 4e-11 43.6 2.3 7.8e-06 26.3 0.6 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AMD21208.1 - 4.1e-09 36.4 0.0 1.1e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 AMD21208.1 - 1.7e-06 27.7 0.2 4.8e-06 26.2 0.2 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AMD21208.1 - 0.00048 19.9 1.0 0.017 14.9 0.9 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DNA_III_psi PF03603.13 AMD21208.1 - 0.078 13.2 0.2 0.18 12.0 0.2 1.6 1 0 0 1 1 1 0 DNA polymerase III psi subunit HAD_2 PF13419.6 AMD21208.1 - 0.15 12.1 0.3 0.48 10.5 0.3 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Aldedh PF00171.22 AMD21209.1 - 7.8e-11 41.1 1.0 7.5e-08 31.3 0.3 2.4 2 1 0 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.17 AMD21209.1 - 0.0039 16.4 0.0 0.0066 15.6 0.0 1.3 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Saw1 PF11561.8 AMD21210.1 - 7.1e-70 235.3 1.0 9.3e-70 234.9 1.0 1.1 1 0 0 1 1 1 1 Single strand annealing-weakened 1 Hph PF13694.6 AMD21211.1 - 0.0019 18.5 0.5 0.0052 17.1 0.4 1.8 1 1 1 2 2 2 1 Sec63/Sec62 complex-interacting family Halogen_Hydrol PF10112.9 AMD21211.1 - 0.003 17.6 1.6 0.81 9.7 0.0 2.3 2 0 0 2 2 2 2 5-bromo-4-chloroindolyl phosphate hydrolysis protein COG5 PF10392.9 AMD21211.1 - 0.0066 16.6 1.7 0.013 15.7 1.7 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Spc29 PF17082.5 AMD21211.1 - 0.06 13.2 0.3 0.13 12.0 0.3 1.5 1 0 0 1 1 1 0 Spindle Pole Component 29 NPV_P10 PF05531.12 AMD21211.1 - 0.09 13.2 1.8 2.1 8.9 0.1 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 AMD21211.1 - 0.13 12.4 4.7 0.36 11.0 4.7 1.7 1 0 0 1 1 1 0 Tropomyosin like DUF16 PF01519.16 AMD21211.1 - 0.29 11.7 3.7 0.76 10.3 3.7 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 TMPIT PF07851.13 AMD21211.1 - 0.4 9.9 2.5 0.53 9.5 1.8 1.4 1 1 0 1 1 1 0 TMPIT-like protein CCDC-167 PF15188.6 AMD21211.1 - 0.44 10.9 4.5 2.9 8.3 1.6 3.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF2730 PF10805.8 AMD21211.1 - 0.53 10.4 3.7 14 5.9 0.1 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF2730) Sec2p PF06428.11 AMD21211.1 - 1.3 9.0 7.0 6.1 6.9 3.2 2.5 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p UPF0242 PF06785.11 AMD21211.1 - 3.2 7.8 10.3 2.3 8.3 6.7 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Syntaxin-6_N PF09177.11 AMD21211.1 - 4.4 7.9 5.9 1.9 9.1 2.5 2.2 2 1 0 2 2 2 0 Syntaxin 6, N-terminal FliJ PF02050.16 AMD21211.1 - 5.5 7.2 10.0 1.7 8.9 6.5 2.0 2 1 0 2 2 2 0 Flagellar FliJ protein Myosin_head PF00063.21 AMD21212.1 - 8.9e-281 933.0 9.5 1.5e-280 932.2 9.5 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 AMD21212.1 - 1.4e-24 86.3 1.4 1.4e-24 86.3 1.4 2.9 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 AMD21212.1 - 0.0015 18.1 15.2 1.8 8.6 0.0 5.8 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_22 PF13401.6 AMD21212.1 - 0.002 18.4 4.4 0.0048 17.2 0.0 3.3 3 1 0 3 3 3 1 AAA domain Myosin_N PF02736.19 AMD21212.1 - 0.0044 16.8 0.1 0.013 15.3 0.1 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 AMD21212.1 - 0.015 15.7 0.6 0.12 12.8 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain Saccharop_dh_N PF04455.12 AMD21212.1 - 0.033 14.6 0.5 1.1 9.7 0.1 3.0 2 0 0 2 2 2 0 LOR/SDH bifunctional enzyme conserved region HSF_DNA-bind PF00447.17 AMD21212.1 - 0.072 13.7 1.0 0.41 11.3 1.0 2.3 1 0 0 1 1 1 0 HSF-type DNA-binding LPP PF04728.13 AMD21212.1 - 0.46 10.9 6.6 0.56 10.6 0.1 4.1 3 0 0 3 3 3 0 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 AMD21212.1 - 0.99 9.4 27.1 5.3 7.1 5.1 3.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 AMD21212.1 - 1.4 9.1 27.6 11 6.1 14.6 3.8 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 AMD21212.1 - 1.4 7.7 30.0 1.2 7.9 9.4 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein Phlebovirus_NSM PF07246.11 AMD21212.1 - 1.5 8.2 11.9 0.5 9.7 8.1 2.2 2 1 0 2 2 2 0 Phlebovirus nonstructural protein NS-M HIP1_clath_bdg PF16515.5 AMD21212.1 - 4.6 7.9 31.4 0.24 12.1 12.5 3.8 2 1 1 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1192 PF06698.11 AMD21212.1 - 4.7 7.3 6.8 2.2 8.4 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) APG6_N PF17675.1 AMD21212.1 - 5.5 7.5 36.4 0.17 12.4 15.5 3.4 2 1 1 3 3 2 0 Apg6 coiled-coil region Fez1 PF06818.15 AMD21212.1 - 6.8 7.1 25.7 0.013 15.9 7.5 2.9 1 1 1 2 2 1 0 Fez1 Synaptobrevin PF00957.21 AMD21213.1 - 1.1e-31 108.4 1.9 1.3e-31 108.2 1.9 1.0 1 0 0 1 1 1 1 Synaptobrevin DUF3671 PF12420.8 AMD21213.1 - 0.017 15.2 0.2 0.021 14.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2040 PF09745.9 AMD21215.1 - 2.7e-08 33.9 9.1 2.7e-08 33.9 9.1 2.2 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) bZIP_2 PF07716.15 AMD21215.1 - 1.9 8.6 7.4 9.5 6.4 0.6 3.1 2 0 0 2 2 2 0 Basic region leucine zipper DNApol_Exo PF18136.1 AMD21216.1 - 4.5e-96 321.3 0.4 8.9e-96 320.3 0.0 1.7 2 0 0 2 2 2 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 AMD21216.1 - 3.6e-54 184.3 0.0 9.6e-54 182.9 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 AMD21216.1 - 0.063 13.0 0.4 0.19 11.4 0.4 1.8 1 1 0 1 1 1 0 3'-5' exonuclease vATP-synt_E PF01991.18 AMD21217.1 - 1.5e-58 197.5 17.0 1.8e-58 197.3 17.0 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit CorA PF01544.18 AMD21218.1 - 5.7e-08 32.4 2.1 1e-07 31.6 2.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SOAR PF16533.5 AMD21219.1 - 0.015 15.3 0.4 0.14 12.2 0.3 2.5 2 0 0 2 2 2 0 STIM1 Orai1-activating region RhoGAP-FF1 PF16512.5 AMD21219.1 - 0.026 15.2 0.5 0.064 13.9 0.5 1.7 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain RPAP3_C PF13877.6 AMD21219.1 - 0.13 12.8 3.9 1 10.0 0.3 3.1 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 SKIP_SNW PF02731.15 AMD21220.1 - 1.1e-54 184.5 4.1 1.1e-54 184.5 4.1 2.3 3 0 0 3 3 3 1 SKIP/SNW domain Antiterm PF03589.13 AMD21220.1 - 0.23 11.8 1.2 1.6 9.2 0.3 2.4 2 0 0 2 2 2 0 Antitermination protein DDE_Tnp_1_6 PF13751.6 AMD21220.1 - 3.3 7.9 7.7 42 4.4 5.7 2.4 2 0 0 2 2 2 0 Transposase DDE domain RNase_P_Rpp14 PF01900.19 AMD21221.1 - 3.7e-32 110.6 0.1 4.6e-32 110.3 0.1 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Swm2 PF17083.5 AMD21221.1 - 0.056 13.4 0.2 3.9 7.5 0.1 2.3 1 1 1 2 2 2 0 Nucleolar protein Swm2 Syntaxin-18_N PF10496.9 AMD21222.1 - 2.8e-18 65.9 1.3 2.8e-18 65.9 1.3 2.5 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 AMD21222.1 - 0.00074 19.5 0.1 0.0024 17.8 0.1 1.9 1 0 0 1 1 1 1 SNARE domain SecE PF00584.20 AMD21222.1 - 1 9.3 3.5 2.4 8.2 1.3 2.4 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex PID PF00640.23 AMD21222.1 - 1.7 8.7 11.4 0.25 11.3 2.1 2.8 1 1 1 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Y2_Tnp PF04986.13 AMD21222.1 - 3.1 7.8 10.4 0.34 10.9 1.0 2.5 2 1 0 2 2 2 0 Putative transposase L31 PF09784.9 AMD21222.1 - 4.2 7.9 11.6 9.4 6.7 3.5 3.2 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 Thymidylat_synt PF00303.19 AMD21223.1 - 7.6e-116 385.9 0.0 8.5e-116 385.8 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Shugoshin_N PF07558.11 AMD21224.1 - 1.2e-15 57.0 7.3 4.2e-15 55.3 7.3 2.0 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 AMD21224.1 - 5.4e-11 42.1 3.9 5.4e-11 42.1 3.9 2.4 2 0 0 2 2 2 1 Shugoshin C terminus Hemocyanin_M PF00372.19 AMD21224.1 - 0.02 14.1 0.5 1.7 7.8 0.3 2.5 2 0 0 2 2 2 0 Hemocyanin, copper containing domain TSC22 PF01166.18 AMD21224.1 - 0.06 13.7 3.9 0.066 13.5 1.0 2.7 2 1 0 2 2 2 0 TSC-22/dip/bun family DASH_Dad2 PF08654.10 AMD21225.1 - 1.1e-30 106.0 0.9 1.3e-30 105.7 0.9 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 Rogdi_lz PF10259.9 AMD21225.1 - 1.9e-05 24.3 1.4 2.1e-05 24.1 1.4 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein DASH_Duo1 PF08651.10 AMD21225.1 - 0.018 14.8 2.6 0.027 14.2 2.6 1.3 1 0 0 1 1 1 0 DASH complex subunit Duo1 Ran-binding PF05508.11 AMD21225.1 - 0.019 14.0 1.6 0.022 13.7 1.6 1.1 1 0 0 1 1 1 0 RanGTP-binding protein DUF2130 PF09903.9 AMD21225.1 - 0.027 13.7 2.2 0.032 13.5 2.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) DUF3452 PF11934.8 AMD21225.1 - 0.028 14.0 0.2 0.031 13.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) DUF1664 PF07889.12 AMD21225.1 - 0.052 13.6 1.1 0.067 13.2 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Lipoprotein_2 PF00921.17 AMD21225.1 - 0.077 12.5 0.0 0.088 12.4 0.0 1.0 1 0 0 1 1 1 0 Borrelia lipoprotein BORCS7 PF16088.5 AMD21225.1 - 0.62 10.4 6.3 4.3 7.7 1.9 2.2 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 7 Nucleoporin_N PF08801.11 AMD21226.1 - 6.1e-57 193.3 4.2 9.4e-57 192.7 4.2 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 AMD21226.1 - 1.9e-30 106.2 6.0 3.5e-30 105.3 6.0 1.4 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Brix PF04427.18 AMD21227.1 - 6.3e-36 124.3 0.4 9.3e-36 123.7 0.4 1.3 1 0 0 1 1 1 1 Brix domain THF_DHG_CYH PF00763.23 AMD21228.1 - 4.7e-25 88.1 0.2 2.4e-24 85.8 0.0 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 AMD21228.1 - 6.7e-18 64.5 0.0 5.8e-11 42.0 0.0 2.6 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FTP PF07504.13 AMD21228.1 - 0.0035 17.1 0.6 0.0082 16.0 0.6 1.6 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif DpaA_N PF16924.5 AMD21228.1 - 0.03 14.4 0.0 0.75 9.9 0.0 3.0 2 1 0 2 2 2 0 Dipicolinate synthase subunit A N-terminal domain RabGAP-TBC PF00566.18 AMD21229.1 - 5.7e-52 176.5 1.7 5.7e-52 176.5 1.7 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Lactamase_B_4 PF13691.6 AMD21230.1 - 7.2e-24 83.2 0.0 1.6e-23 82.1 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 AMD21230.1 - 2.6e-08 33.6 0.0 0.00048 19.7 0.0 2.5 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Vps5 PF09325.10 AMD21231.1 - 4e-79 265.5 9.7 6.6e-79 264.8 9.7 1.4 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 AMD21231.1 - 1.3e-23 83.1 0.2 5.3e-23 81.1 0.0 2.1 2 0 0 2 2 2 1 PX domain BAR_3_WASP_bdg PF10456.9 AMD21231.1 - 0.0081 15.7 1.7 0.028 13.9 1.8 2.0 2 1 0 2 2 2 1 WASP-binding domain of Sorting nexin protein FlaC_arch PF05377.11 AMD21231.1 - 5.8 7.4 11.1 0.84 10.1 0.4 3.3 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Alg6_Alg8 PF03155.15 AMD21232.1 - 2.5e-164 547.8 35.9 2.9e-164 547.6 35.9 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Cytochrom_C1 PF02167.15 AMD21234.1 - 1.6e-94 315.7 0.0 2e-94 315.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 AMD21234.1 - 0.00071 19.8 0.0 0.0013 19.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 AMD21234.1 - 0.0049 18.0 0.1 0.015 16.4 0.1 1.8 2 1 0 2 2 2 1 Cytochrome c Actin PF00022.19 AMD21235.1 - 7.3e-52 176.3 0.0 4.2e-36 124.4 0.0 2.6 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 AMD21235.1 - 2.6e-06 26.5 0.0 0.0065 15.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein NuA4 PF09340.10 AMD21236.1 - 2.6e-20 72.1 0.3 3.4e-20 71.7 0.3 1.2 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Malate_synthase PF01274.22 AMD21236.1 - 0.033 12.5 0.1 0.033 12.5 0.1 1.0 1 0 0 1 1 1 0 Malate synthase DUF668 PF05003.12 AMD21236.1 - 0.1 13.1 0.2 0.13 12.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF668) DUF5340 PF17275.2 AMD21236.1 - 0.45 10.7 4.3 0.7 10.1 4.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5340) DUF2811 PF10929.8 AMD21236.1 - 0.54 10.6 3.1 6.7 7.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2811) AIM24 PF01987.17 AMD21237.1 - 1.2e-25 90.5 0.0 1.5e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 tRNA-synt_His PF13393.6 AMD21238.1 - 7.9e-38 130.5 0.1 6.2e-37 127.5 0.1 2.0 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 AMD21238.1 - 5.8e-14 52.0 0.0 1.1e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 AMD21238.1 - 0.0051 16.3 0.1 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs IDO PF01231.18 AMD21239.1 - 4e-148 493.8 0.0 4.9e-148 493.5 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Clathrin_propel PF01394.20 AMD21239.1 - 0.061 13.7 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Clathrin propeller repeat Cid2 PF09774.9 AMD21240.1 - 6.2e-29 101.5 2.6 8.3e-29 101.1 2.6 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 HHH_2 PF12826.7 AMD21240.1 - 0.06 13.4 0.0 1.2 9.3 0.0 2.3 1 1 0 1 1 1 0 Helix-hairpin-helix motif Ribos_L4_asso_C PF14374.6 AMD21240.1 - 0.076 13.1 0.2 0.076 13.1 0.2 2.1 3 0 0 3 3 3 0 60S ribosomal protein L4 C-terminal domain Lgl_C PF08596.10 AMD21241.1 - 3.3e-111 371.8 0.5 7e-111 370.7 0.3 1.6 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 AMD21241.1 - 1.3e-08 35.0 0.5 0.012 15.9 0.0 5.4 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD21241.1 - 0.0017 19.1 0.8 45 5.2 0.0 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Pkinase PF00069.25 AMD21242.1 - 2.7e-60 204.0 0.0 6.2e-60 202.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21242.1 - 1.8e-35 122.5 0.0 3.5e-35 121.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 AMD21242.1 - 4.2e-21 74.8 16.3 7.3e-13 48.4 5.8 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 AMD21242.1 - 5.1e-19 67.9 35.1 8.7e-11 41.5 14.3 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 AMD21242.1 - 1.1e-10 42.0 1.6 2.7e-10 40.8 0.5 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Pkinase_fungal PF17667.1 AMD21242.1 - 0.0054 15.6 0.0 0.013 14.3 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AMD21242.1 - 0.0084 15.5 0.0 0.09 12.1 0.0 2.2 1 1 1 2 2 2 1 Kinase-like C2 PF00168.30 AMD21242.1 - 0.012 15.9 0.1 0.032 14.5 0.1 1.8 1 0 0 1 1 1 0 C2 domain zinc_ribbon_16 PF17034.5 AMD21243.1 - 7.8e-27 94.0 8.4 1.9e-26 92.7 8.5 1.8 1 1 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 AMD21243.1 - 7e-05 22.4 8.8 7e-05 22.4 8.8 2.6 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AMD21243.1 - 0.011 16.5 0.1 8.5 7.4 0.0 4.0 3 0 0 3 3 3 0 WD domain, G-beta repeat zf-RING_2 PF13639.6 AMD21243.1 - 9.2 6.7 10.9 3.7 8.0 3.4 3.2 3 0 0 3 3 3 0 Ring finger domain zf-HC5HC2H_2 PF13832.6 AMD21244.1 - 2.8e-31 107.9 6.4 2.8e-31 107.9 6.4 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 AMD21244.1 - 3.7e-28 97.6 4.5 3.7e-28 97.6 4.5 3.5 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 AMD21244.1 - 1.8e-14 52.9 3.1 1.8e-14 52.9 3.1 2.7 2 0 0 2 2 2 1 PHD-finger EPL1 PF10513.9 AMD21244.1 - 3.7e-14 53.4 3.1 3.7e-14 53.4 3.1 2.0 2 1 0 2 2 2 1 Enhancer of polycomb-like PHD PF00628.29 AMD21244.1 - 6.7e-12 45.1 19.4 5.5e-11 42.2 4.3 2.6 2 0 0 2 2 2 2 PHD-finger Bromodomain PF00439.25 AMD21244.1 - 0.0096 16.0 0.1 0.028 14.5 0.1 1.7 1 0 0 1 1 1 1 Bromodomain Prok-RING_1 PF14446.6 AMD21244.1 - 0.071 13.1 16.3 0.03 14.2 4.7 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.22 AMD21244.1 - 0.076 12.9 0.1 0.076 12.9 0.1 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 AMD21244.1 - 0.15 12.4 17.6 0.73 10.2 8.9 2.6 2 0 0 2 2 2 0 RING-like domain C1_2 PF03107.16 AMD21244.1 - 5.1 7.5 22.7 0.16 12.3 2.6 2.9 3 0 0 3 3 3 0 C1 domain WD40 PF00400.32 AMD21245.1 - 4.1e-10 40.1 0.8 0.0076 17.1 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21245.1 - 0.04 14.2 0.0 5.8 7.3 0.0 3.3 3 1 2 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DUF870 PF05912.11 AMD21245.1 - 0.06 13.4 0.1 0.15 12.0 0.1 1.7 1 1 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF870) Pkinase PF00069.25 AMD21247.1 - 1.5e-67 227.8 0.0 2.1e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21247.1 - 3.7e-40 137.8 0.0 5.6e-40 137.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD21247.1 - 2e-05 23.7 0.4 2e-05 23.7 0.4 2.1 2 1 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 AMD21247.1 - 6.3e-05 21.9 0.0 0.00012 21.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AMD21247.1 - 0.0013 18.2 0.0 0.0024 17.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 AMD21247.1 - 0.014 14.5 0.0 0.026 13.6 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Lipl32 PF12103.8 AMD21247.1 - 0.023 14.4 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order DEAD PF00270.29 AMD21248.1 - 4.5e-44 150.3 0.0 8.6e-44 149.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21248.1 - 1.8e-29 102.3 0.2 1.8e-28 99.1 0.2 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Arcadin_1 PF18653.1 AMD21248.1 - 0.26 11.4 1.8 1.3 9.1 0.0 2.8 3 1 1 4 4 4 0 Arcadin 1 PNP_UDP_1 PF01048.20 AMD21249.1 - 7.1e-38 130.2 0.0 8.5e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily WD40 PF00400.32 AMD21250.1 - 1.7e-18 66.6 18.3 0.0002 22.1 0.5 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21250.1 - 5.7e-06 26.5 3.0 0.23 11.8 0.4 4.5 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 AMD21250.1 - 0.012 15.6 2.0 0.059 13.3 0.4 2.4 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Kelch_6 PF13964.6 AMD21250.1 - 0.08 13.3 1.3 2.7 8.4 0.0 3.1 3 1 0 3 3 3 0 Kelch motif BCS1_N PF08740.11 AMD21252.1 - 1.8e-47 161.7 0.3 2.7e-47 161.2 0.3 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 AMD21252.1 - 1.8e-22 80.2 0.0 1.2e-21 77.5 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AMD21252.1 - 0.0014 19.1 0.0 0.0054 17.1 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AMD21252.1 - 0.002 17.9 0.0 0.0037 17.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 AMD21252.1 - 0.0021 17.6 0.0 0.0091 15.5 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 AMD21252.1 - 0.0037 17.3 0.0 0.012 15.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AMD21252.1 - 0.008 16.7 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 AMD21252.1 - 0.011 15.0 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 AMD21252.1 - 0.016 14.9 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 AMD21252.1 - 0.021 14.6 0.0 0.047 13.4 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 AMD21252.1 - 0.026 14.7 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 AMD21252.1 - 0.029 14.2 0.2 1.9 8.2 0.1 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 AMD21252.1 - 0.029 14.6 0.0 0.074 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AMD21252.1 - 0.035 13.7 0.0 0.4 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AMD21252.1 - 0.042 14.2 0.0 0.097 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 AMD21252.1 - 0.044 14.3 0.0 0.082 13.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Rad17 PF03215.15 AMD21252.1 - 0.046 13.6 0.0 0.23 11.4 0.0 2.0 1 1 1 2 2 2 0 Rad17 P-loop domain ATPase PF06745.13 AMD21252.1 - 0.057 12.8 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_14 PF13173.6 AMD21252.1 - 0.065 13.3 0.0 0.16 12.0 0.0 1.7 2 0 0 2 2 1 0 AAA domain Gram_pos_anchor PF00746.21 AMD21252.1 - 0.067 13.1 0.4 0.17 11.8 0.4 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif AAA_21 PF13304.6 AMD21252.1 - 0.079 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TIP49 PF06068.13 AMD21252.1 - 0.12 11.6 0.0 0.43 9.7 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain NACHT PF05729.12 AMD21252.1 - 0.12 12.2 0.0 0.33 10.8 0.0 1.7 2 0 0 2 2 1 0 NACHT domain AAA_11 PF13086.6 AMD21252.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AMD21252.1 - 0.13 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 AMD21252.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Polyoma_lg_T_C PF06431.11 AMD21252.1 - 0.19 10.5 0.0 0.27 10.1 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus AAA_17 PF13207.6 AMD21252.1 - 0.19 12.1 0.0 0.35 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Lipase_GDSL_2 PF13472.6 AMD21253.1 - 1.2e-24 87.7 0.0 1.4e-24 87.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 AMD21253.1 - 4.7e-11 43.0 0.0 1.7e-10 41.2 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ZnuA PF01297.17 AMD21253.1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Pyr_redox_2 PF07992.14 AMD21254.1 - 9.8e-07 28.3 0.0 0.00039 19.7 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AMD21254.1 - 0.0037 17.4 0.0 0.0091 16.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AMD21254.1 - 0.014 15.4 0.0 0.048 13.6 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Shikimate_DH PF01488.20 AMD21254.1 - 0.16 12.0 0.0 10 6.2 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase F1F0-ATPsyn_F PF10791.9 AMD21255.1 - 1.4e-39 134.4 0.2 1.6e-39 134.2 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 AMD21255.1 - 0.0083 16.5 0.0 0.0093 16.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f LSM PF01423.22 AMD21256.1 - 4.7e-18 64.6 0.0 5.4e-18 64.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AMD21256.1 - 0.00011 22.2 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 AMD21256.1 - 0.00096 19.2 0.1 0.0012 18.9 0.1 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain RhoGAP PF00620.27 AMD21257.1 - 3.1e-41 140.7 3.8 5.2e-41 140.0 1.5 2.3 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 AMD21257.1 - 9.3e-12 45.0 27.8 5.3e-06 26.6 8.2 2.5 2 0 0 2 2 2 2 LIM domain Golgin_A5 PF09787.9 AMD21257.1 - 0.021 14.3 7.5 0.074 12.5 7.5 1.9 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 AMD21257.1 - 0.19 11.0 0.5 0.42 9.9 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 AMD21257.1 - 0.22 11.6 5.2 1.7 8.7 4.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 AMD21257.1 - 0.31 11.6 9.0 0.4 11.2 5.6 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region HALZ PF02183.18 AMD21257.1 - 0.36 11.1 5.3 6.4 7.1 2.1 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper JIP_LZII PF16471.5 AMD21257.1 - 0.8 9.9 7.4 2.7 8.2 7.4 2.0 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Complex1_LYR PF05347.15 AMD21258.1 - 7e-12 45.2 1.2 8.2e-12 45.0 1.2 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Glyco_transf_21 PF13506.6 AMD21259.1 - 6e-18 64.9 0.0 1.2e-14 54.1 0.0 2.5 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 AMD21259.1 - 3.8e-12 46.6 0.0 1.7e-11 44.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 AMD21259.1 - 0.00099 19.0 0.0 0.0022 17.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 AIRC PF00731.20 AMD21260.1 - 1.1e-63 213.2 5.4 2.1e-62 209.1 2.9 2.3 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.22 AMD21260.1 - 2.3e-59 199.8 0.0 3.6e-59 199.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 AMD21260.1 - 7.4e-19 67.2 0.1 1.4e-18 66.3 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain AlaDh_PNT_C PF01262.21 AMD21260.1 - 0.0028 17.0 0.2 0.008 15.5 0.2 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 AMD21260.1 - 0.0043 16.4 0.1 0.009 15.4 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Dala_Dala_lig_C PF07478.13 AMD21260.1 - 0.023 14.3 0.0 0.14 11.6 0.0 2.2 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus FleQ PF06490.11 AMD21260.1 - 0.024 15.0 0.0 0.28 11.6 0.0 2.7 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ TrkA_N PF02254.18 AMD21260.1 - 0.045 14.0 0.1 0.27 11.5 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain SPA PF08616.10 AMD21261.1 - 4.9e-28 97.4 0.1 1.1e-27 96.2 0.1 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 AMD21261.1 - 2.1e-26 93.0 0.0 5.1e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 AMD21261.1 - 4.7e-06 25.5 2.1 0.03 13.0 0.0 2.7 3 0 0 3 3 3 2 Transport protein Avl9 RRM_1 PF00076.22 AMD21262.1 - 2.3e-12 46.5 0.0 4.3e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 AMD21262.1 - 0.018 15.6 3.9 0.018 15.6 3.9 2.7 2 1 1 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 Mito_carr PF00153.27 AMD21264.1 - 6e-59 196.0 0.7 1.8e-20 72.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_60s PF00428.19 AMD21265.1 - 8.5e-25 87.2 9.5 1e-24 86.9 9.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3482 PF11981.8 AMD21265.1 - 0.062 12.7 0.8 0.085 12.2 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Peptidase_M22 PF00814.25 AMD21266.1 - 6.4e-85 285.1 0.0 7.7e-85 284.9 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 AMD21266.1 - 0.056 13.1 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus DASH_Spc34 PF08657.10 AMD21267.1 - 1.4e-85 287.2 3.1 1.6e-85 287.0 3.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 HALZ PF02183.18 AMD21267.1 - 0.075 13.3 0.4 0.075 13.3 0.4 3.4 3 0 0 3 3 3 0 Homeobox associated leucine zipper PRKG1_interact PF15898.5 AMD21267.1 - 0.28 12.1 3.8 0.69 10.8 3.8 1.7 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain WD40 PF00400.32 AMD21268.1 - 4.5e-32 109.6 9.1 5.9e-07 30.1 0.8 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21268.1 - 2.3e-11 43.8 0.0 0.035 14.4 0.0 5.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD21268.1 - 2.2e-08 33.2 4.2 0.0026 16.5 0.0 4.8 1 1 4 5 5 5 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 AMD21268.1 - 1.7e-06 28.0 0.3 0.00014 21.9 0.0 3.5 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Mdv1 PF11542.8 AMD21268.1 - 0.00034 20.5 0.0 0.00075 19.4 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial division protein 1 Caf4 PF11615.8 AMD21268.1 - 0.00075 19.4 0.2 0.49 10.4 0.1 2.6 1 1 1 2 2 2 2 CCR4-associated factor 4 WD40_like PF17005.5 AMD21268.1 - 0.0014 18.1 0.1 0.021 14.1 0.0 2.5 2 1 0 2 2 2 1 WD40-like domain LIN37 PF15306.6 AMD21268.1 - 0.058 13.6 3.8 0.04 14.1 1.2 1.9 2 0 0 2 2 2 0 LIN37 DUF16 PF01519.16 AMD21268.1 - 0.93 10.0 3.9 4.7 7.8 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 Nefa_Nip30_N PF10187.9 AMD21269.1 - 4.9e-05 23.6 13.3 4.9e-05 23.6 13.3 1.7 1 1 1 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 FmdA_AmdA PF03069.15 AMD21269.1 - 0.00045 19.2 0.2 0.00058 18.8 0.2 1.1 1 0 0 1 1 1 1 Acetamidase/Formamidase family BPL_N PF09825.9 AMD21269.1 - 0.43 9.6 5.8 0.47 9.5 5.8 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Fcf1 PF04900.12 AMD21270.1 - 2.5e-34 117.6 0.3 6.6e-34 116.3 0.2 1.6 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 AMD21270.1 - 1.8e-13 50.8 0.1 5.4e-13 49.3 0.0 1.7 2 0 0 2 2 2 1 PIN like domain Imm-NTF2 PF15655.6 AMD21270.1 - 0.08 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 NTF2 fold immunity protein DUF5394 PF17372.2 AMD21270.1 - 0.11 12.0 0.4 0.16 11.5 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5394) PP2C PF00481.21 AMD21271.1 - 5.7e-68 229.3 0.2 8.8e-68 228.7 0.2 1.3 1 1 0 1 1 1 1 Protein phosphatase 2C Med2 PF11214.8 AMD21272.1 - 5.6e-34 116.3 4.1 1.3e-33 115.1 4.1 1.6 1 0 0 1 1 1 1 Mediator complex subunit 2 Med29 PF11568.8 AMD21272.1 - 0.02 15.1 1.4 0.043 14.0 1.4 1.5 1 0 0 1 1 1 0 Mediator complex subunit 29 ATP-synt_DE_N PF02823.16 AMD21273.1 - 1.8e-14 53.4 0.0 2.5e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Rad21_Rec8_N PF04825.13 AMD21274.1 - 2.7e-21 75.8 0.0 5.6e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 AMD21274.1 - 5.4e-10 38.4 0.0 1e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein DRIM PF07539.12 AMD21275.1 - 2e-154 515.3 3.5 2e-154 515.3 3.5 4.7 3 2 1 5 5 5 1 Down-regulated in metastasis RIX1 PF08167.12 AMD21275.1 - 0.02 14.6 0.0 0.02 14.6 0.0 5.0 6 0 0 6 6 6 0 rRNA processing/ribosome biogenesis HEAT PF02985.22 AMD21275.1 - 0.034 14.4 6.5 14 6.2 0.0 7.3 8 0 0 8 8 8 0 HEAT repeat DUF4042 PF13251.6 AMD21275.1 - 0.88 9.2 4.5 2.4 7.8 0.0 4.1 6 0 0 6 6 6 0 Domain of unknown function (DUF4042) HMG_box PF00505.19 AMD21276.1 - 9e-17 61.3 2.4 1.6e-16 60.5 2.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AMD21276.1 - 3e-13 50.2 1.2 5.3e-13 49.4 1.2 1.4 1 0 0 1 1 1 1 HMG-box domain DUF155 PF02582.14 AMD21277.1 - 4.9e-56 189.6 1.0 7.4e-56 189.0 1.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 AMD21277.1 - 0.03 14.8 0.1 0.085 13.3 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Histone_H2A_C PF16211.5 AMD21278.1 - 4.5e-21 74.3 1.2 7.4e-21 73.6 1.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 AMD21278.1 - 1.1e-17 64.6 0.0 1.4e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AMD21278.1 - 2.8e-06 27.5 0.0 5.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AMD21279.1 - 1.3e-20 74.1 2.8 1.7e-20 73.7 2.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AMD21279.1 - 1.7e-06 28.2 0.1 3.6e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 AMD21279.1 - 0.0016 18.9 0.0 0.0028 18.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 AMD21279.1 - 0.025 14.8 0.0 0.036 14.3 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 AMD21279.1 - 0.027 14.5 0.2 0.032 14.3 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein Trehalase PF01204.18 AMD21280.1 - 2.2e-183 610.8 0.1 2.5e-183 610.6 0.1 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 AMD21280.1 - 1.1e-16 60.2 0.7 2e-16 59.4 0.7 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Ran_BP1 PF00638.18 AMD21281.1 - 3.9e-54 182.1 3.0 5.5e-54 181.6 3.0 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 AMD21281.1 - 1.6e-05 24.8 1.3 0.00021 21.2 1.3 2.1 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 AMD21281.1 - 0.039 14.2 0.2 0.096 13.0 0.2 1.7 1 1 0 1 1 1 0 VID27 PH-like domain Prenyltransf PF01255.19 AMD21282.1 - 9.9e-71 237.8 0.0 1.2e-70 237.6 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase polyprenyl_synt PF00348.17 AMD21283.1 - 3.7e-69 232.6 0.0 4.7e-68 229.0 0.0 2.3 1 1 0 1 1 1 1 Polyprenyl synthetase Mannosyl_trans2 PF04188.13 AMD21284.1 - 1.4e-64 219.1 44.2 6.2e-62 210.3 44.2 2.2 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) DUF1980 PF09323.10 AMD21284.1 - 2.4 8.0 6.1 1.4 8.8 1.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) RCR PF12273.8 AMD21285.1 - 9.2e-27 94.1 1.2 1.2e-26 93.7 1.2 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Git3 PF11710.8 AMD21285.1 - 0.045 13.5 0.0 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 HA2 PF04408.23 AMD21286.1 - 6.3e-22 77.9 0.0 1.4e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AMD21286.1 - 9.6e-22 77.1 0.0 2.7e-21 75.7 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AMD21286.1 - 2.4e-12 47.2 0.0 8e-12 45.5 0.0 1.9 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD21286.1 - 4.5e-09 36.3 0.1 7.8e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AMD21286.1 - 2e-07 31.4 0.1 6.6e-07 29.7 0.1 1.9 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 AMD21286.1 - 0.00094 19.2 1.1 0.0014 18.6 0.1 1.8 2 0 0 2 2 2 1 Flavivirus DEAD domain SRP54 PF00448.22 AMD21286.1 - 0.0013 18.4 0.0 0.0036 17.0 0.0 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 AMD21286.1 - 0.0014 18.9 0.1 0.0026 18.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AMD21286.1 - 0.0024 17.6 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AMD21286.1 - 0.0039 17.7 0.1 0.021 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 AMD21286.1 - 0.0058 16.7 0.0 1.7 8.6 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 AMD21286.1 - 0.05 12.7 0.0 0.1 11.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 AMD21286.1 - 0.064 13.0 0.0 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF2075 PF09848.9 AMD21286.1 - 0.067 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 AMD21286.1 - 0.099 12.1 0.0 0.3 10.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC1 PF03109.16 AMD21287.1 - 1.3e-32 112.5 0.0 3.7e-32 111.0 0.0 1.8 2 0 0 2 2 2 1 ABC1 family Rad52_Rad22 PF04098.15 AMD21287.1 - 0.063 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Rad52/22 family double-strand break repair protein Mtp PF03821.16 AMD21288.1 - 0.049 13.2 0.2 0.059 13.0 0.2 1.3 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter WD40 PF00400.32 AMD21289.1 - 6e-13 49.0 19.8 6.2e-05 23.7 0.2 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21289.1 - 3.3e-12 46.6 8.8 0.0011 19.2 0.7 5.1 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AMD21289.1 - 2.9e-07 29.8 0.1 3.8e-05 22.8 0.0 2.9 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AMD21289.1 - 0.034 13.5 0.9 2.1 7.6 0.0 2.6 2 1 0 2 2 2 0 WD40-like domain CBS PF00571.28 AMD21290.1 - 2e-24 85.8 5.5 1.4e-10 41.5 0.2 4.2 4 0 0 4 4 4 4 CBS domain dCache_1 PF02743.18 AMD21290.1 - 0.051 13.4 0.1 0.18 11.6 0.1 1.7 1 1 0 1 1 1 0 Cache domain HTH_9 PF08221.11 AMD21290.1 - 0.41 10.8 1.9 3.8 7.7 0.1 2.9 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain OPT PF03169.15 AMD21291.1 - 1.8e-150 502.6 19.4 2e-150 502.4 19.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein BCNT PF07572.12 AMD21292.1 - 2.8e-24 85.0 0.2 2.8e-24 85.0 0.2 2.0 2 0 0 2 2 2 1 Bucentaur or craniofacial development DTW PF03942.15 AMD21292.1 - 0.041 13.6 0.0 0.072 12.8 0.0 1.4 1 1 0 1 1 1 0 DTW domain KH_1 PF00013.29 AMD21293.1 - 8e-35 118.5 6.5 5.4e-11 42.2 1.8 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 AMD21293.1 - 8.8e-11 41.5 5.4 0.0048 16.7 0.5 3.5 3 0 0 3 3 3 3 KH domain MOEP19 PF16005.5 AMD21293.1 - 1.5e-06 28.1 0.1 0.05 13.6 0.0 3.2 3 0 0 3 3 3 3 KH-like RNA-binding domain KH_5 PF13184.6 AMD21293.1 - 0.00032 20.7 3.6 1.6 8.8 0.2 3.7 3 0 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 AMD21293.1 - 0.00048 19.9 1.1 1.2 9.1 0.1 3.0 2 1 1 3 3 3 2 KH domain SLD3 PF08639.10 AMD21294.1 - 3.3e-30 105.4 19.4 1.4e-21 76.9 14.3 2.8 1 1 1 2 2 2 2 DNA replication regulator SLD3 Sld3_N PF18523.1 AMD21294.1 - 3.1e-21 75.6 0.1 9e-21 74.2 0.1 1.9 1 0 0 1 1 1 1 Sld3 N-terminal domain TAF6_C PF07571.13 AMD21295.1 - 2.2e-29 101.6 0.0 4.9e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 AMD21295.1 - 3.2e-27 94.5 0.4 8.4e-27 93.1 0.4 1.7 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 AMD21295.1 - 0.0023 18.0 0.1 0.0065 16.5 0.1 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 AMD21295.1 - 0.01 16.2 2.4 0.041 14.3 0.3 2.3 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 CLASP_N PF12348.8 AMD21295.1 - 0.016 14.8 0.4 0.37 10.3 0.1 2.3 2 0 0 2 2 2 0 CLASP N terminal Sec7_N PF12783.7 AMD21295.1 - 0.044 13.7 7.1 2.6 8.0 0.1 3.3 1 1 2 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF348 PF03990.14 AMD21295.1 - 0.088 12.6 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain TAF4 PF05236.14 AMD21295.1 - 0.092 12.5 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CENP-S PF15630.6 AMD21295.1 - 0.22 11.9 1.7 2.4 8.6 0.1 3.0 3 0 0 3 3 3 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 AMD21295.1 - 0.46 10.8 3.2 0.8 10.0 0.1 2.8 4 0 0 4 4 4 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DASH_Dad3 PF08656.10 AMD21296.1 - 6.8e-23 80.5 2.3 7.4e-23 80.4 2.3 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 PKHD_C PF18331.1 AMD21296.1 - 0.016 15.3 0.2 0.027 14.5 0.2 1.5 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain NRN1 PF15056.6 AMD21296.1 - 0.096 12.8 0.0 0.21 11.7 0.0 1.5 1 1 0 1 1 1 0 Neuritin protein family WD40 PF00400.32 AMD21297.1 - 2.6e-10 40.7 5.2 0.0014 19.4 0.2 5.6 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21297.1 - 1.1e-08 35.3 0.7 0.011 16.0 0.0 5.0 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD21297.1 - 0.02 14.8 0.0 0.33 10.8 0.0 2.5 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A CUE PF02845.16 AMD21299.1 - 1.7e-08 34.0 0.1 4.4e-08 32.7 0.1 1.7 1 0 0 1 1 1 1 CUE domain AA_permease PF00324.21 AMD21300.1 - 8.6e-49 166.4 38.2 8.6e-49 166.4 38.2 1.4 2 0 0 2 2 2 1 Amino acid permease SLC12 PF03522.15 AMD21300.1 - 4.1e-17 62.3 2.7 4.1e-08 32.7 0.1 3.1 3 0 0 3 3 3 3 Solute carrier family 12 Pox_MCEL PF03291.16 AMD21301.1 - 1.5e-98 330.0 0.1 2e-98 329.6 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 AMD21301.1 - 1.2e-10 41.9 0.0 2.5e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD21301.1 - 8.1e-08 32.9 0.2 3e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD21301.1 - 2.4e-07 30.7 0.0 5.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD21301.1 - 2.3e-06 28.2 0.1 6.2e-06 26.8 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD21301.1 - 3.5e-06 26.9 0.5 6.7e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 AMD21301.1 - 0.026 13.8 0.0 0.092 12.0 0.0 1.8 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase NNMT_PNMT_TEMT PF01234.17 AMD21301.1 - 0.037 13.2 0.0 0.088 12.0 0.0 1.6 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family PCMT PF01135.19 AMD21301.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 AMD21301.1 - 0.17 11.5 0.0 0.34 10.5 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DEAD PF00270.29 AMD21302.1 - 2.7e-45 154.3 0.0 1e-44 152.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21302.1 - 4.5e-21 75.3 0.0 2.6e-20 72.8 0.0 2.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TTRAP PF14203.6 AMD21302.1 - 0.027 14.4 1.3 0.08 12.9 0.1 2.4 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein DUF5600 PF18150.1 AMD21302.1 - 0.15 12.6 1.6 0.7 10.5 1.6 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5600) PPR_3 PF13812.6 AMD21303.1 - 0.0086 16.1 0.1 0.2 11.8 0.0 2.5 2 0 0 2 2 2 1 Pentatricopeptide repeat domain Sulfotransfer_4 PF17784.1 AMD21303.1 - 0.12 12.2 0.1 1.3 8.8 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase domain EF-hand_6 PF13405.6 AMD21304.1 - 4.5e-11 41.7 1.3 0.00014 21.5 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 AMD21304.1 - 8.6e-11 42.1 1.4 7.9e-08 32.6 0.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 AMD21304.1 - 1.8e-09 37.8 0.1 0.0014 19.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 AMD21304.1 - 3.3e-09 35.7 3.3 0.00099 18.5 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 AMD21304.1 - 4.4e-07 29.7 0.6 5.1e-06 26.2 0.3 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_14 PF17959.1 AMD21304.1 - 0.00033 20.9 0.1 0.79 10.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 AMD21304.1 - 0.0026 18.6 0.0 0.0039 18.0 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain FDX-ACB PF03147.14 AMD21304.1 - 0.14 12.6 0.1 0.43 11.0 0.1 1.8 1 1 0 1 1 1 0 Ferredoxin-fold anticodon binding domain PAS PF00989.25 AMD21305.1 - 1.3e-12 47.7 0.0 2.8e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 AMD21305.1 - 1.2e-06 28.5 9.8 1.2e-06 28.5 9.8 2.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_4 PF08448.10 AMD21305.1 - 0.1 12.9 0.0 0.36 11.1 0.0 2.0 2 0 0 2 2 2 0 PAS fold PAS_3 PF08447.12 AMD21305.1 - 0.15 12.4 0.0 0.5 10.7 0.0 1.9 1 0 0 1 1 1 0 PAS fold tRNA_bind PF01588.20 AMD21306.1 - 1.3e-27 95.8 0.0 2.2e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain Sugar_tr PF00083.24 AMD21307.1 - 1.3e-94 317.6 19.9 1.6e-94 317.4 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD21307.1 - 4.9e-28 98.1 25.4 4.9e-28 98.1 25.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SUR7 PF06687.12 AMD21307.1 - 0.36 10.4 0.0 0.36 10.4 0.0 3.5 3 1 1 4 4 4 0 SUR7/PalI family Ribosomal_L27A PF00828.19 AMD21308.1 - 4.1e-22 79.2 0.0 6.7e-22 78.5 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A HD_3 PF13023.6 AMD21309.1 - 9.3e-39 133.0 0.5 1.1e-38 132.7 0.5 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 AMD21309.1 - 8.6e-10 38.7 0.3 1.1e-09 38.3 0.3 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 AMD21309.1 - 7.4e-06 26.2 0.1 1.5e-05 25.2 0.1 1.5 1 1 0 1 1 1 1 HD domain WASH-7_C PF14746.6 AMD21309.1 - 0.024 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Glycos_transf_4 PF00953.21 AMD21310.1 - 3.6e-31 108.3 10.7 3.6e-31 108.3 10.7 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 4 WD40 PF00400.32 AMD21311.1 - 3.6e-21 75.1 13.9 4.5e-05 24.1 1.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21311.1 - 7.8e-12 45.3 0.6 0.024 14.9 0.1 3.4 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain YmzC PF14157.6 AMD21311.1 - 0.0026 17.8 0.0 0.17 12.0 0.0 2.6 2 0 0 2 2 2 1 YmzC-like protein Rav1p_C PF12234.8 AMD21311.1 - 0.034 12.6 0.0 0.048 12.1 0.0 1.1 1 0 0 1 1 1 0 RAVE protein 1 C terminal GSHPx PF00255.19 AMD21312.1 - 2.3e-47 159.1 0.1 3.1e-47 158.6 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 AMD21312.1 - 4.1e-05 23.5 0.1 0.0001 22.2 0.1 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AMD21312.1 - 0.00015 21.5 0.0 0.00022 20.9 0.0 1.6 1 1 0 1 1 1 1 Redoxin SNF2_N PF00176.23 AMD21313.1 - 3.7e-76 256.1 0.1 8.4e-76 254.9 0.1 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 AMD21313.1 - 1e-38 131.9 2.0 1e-38 131.9 2.0 3.5 5 0 0 5 5 5 1 SLIDE HAND PF09110.11 AMD21313.1 - 1.2e-28 100.1 0.6 1.2e-28 100.1 0.6 4.4 5 0 0 5 5 4 1 HAND Helicase_C PF00271.31 AMD21313.1 - 4.3e-20 72.1 0.0 1.6e-19 70.2 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD21313.1 - 8.8e-12 45.4 0.1 1.1e-10 41.8 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AMD21313.1 - 2.7e-10 39.9 0.3 7e-10 38.5 0.3 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 AMD21313.1 - 4.9e-05 23.2 0.0 0.00012 21.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 AMD21313.1 - 8.5e-05 22.7 0.1 0.26 11.5 0.1 3.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain ERCC3_RAD25_C PF16203.5 AMD21313.1 - 0.00063 19.0 0.1 0.00063 19.0 0.1 2.2 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase DEAD_2 PF06733.15 AMD21313.1 - 0.011 15.4 0.1 0.028 14.0 0.1 1.7 1 0 0 1 1 1 0 DEAD_2 AAA_14 PF13173.6 AMD21313.1 - 0.014 15.5 0.5 0.13 12.3 0.1 2.7 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 AMD21314.1 - 5.6e-07 30.2 2.2 0.2 12.6 0.5 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat MMR_HSR1 PF01926.23 AMD21315.1 - 6.6e-16 58.4 0.1 4.2e-14 52.6 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD21315.1 - 7.4e-08 32.1 0.1 1.1e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AMD21315.1 - 6.3e-06 26.2 0.4 0.017 15.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 AMD21315.1 - 0.1 13.1 0.3 1.2 9.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 AMD21315.1 - 0.2 10.6 0.1 0.56 9.1 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 AMD21315.1 - 1.4 8.9 6.7 0.54 10.3 0.7 3.0 3 1 0 3 3 3 0 Dynamin family Use1 PF09753.9 AMD21316.1 - 2e-12 47.4 3.4 3.2e-12 46.7 3.4 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 AAA_15 PF13175.6 AMD21316.1 - 0.66 9.6 8.0 0.78 9.4 8.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Bystin PF05291.11 AMD21317.1 - 4e-123 410.4 0.1 5.9e-123 409.8 0.1 1.2 1 0 0 1 1 1 1 Bystin FGE-sulfatase PF03781.16 AMD21317.1 - 0.11 12.0 0.2 0.19 11.3 0.2 1.3 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 RCC1 PF00415.18 AMD21318.1 - 5.2e-70 231.9 0.3 1.2e-10 41.9 0.2 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AMD21318.1 - 7.9e-43 143.4 24.3 3.4e-10 39.5 0.0 7.3 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat His_biosynth PF00977.21 AMD21319.1 - 1.9e-44 151.8 0.5 9.5e-44 149.6 0.5 2.1 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 AMD21319.1 - 2e-18 66.9 0.0 3.7e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 AMD21319.1 - 4.6e-09 36.2 0.0 9e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 AMD21319.1 - 6.8e-07 29.3 0.0 0.0051 16.7 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family Peptidase_S51 PF03575.17 AMD21319.1 - 0.0075 15.9 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S51 Peptidase_C26 PF07722.13 AMD21319.1 - 0.034 13.9 0.1 0.41 10.4 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 BtpA PF03437.15 AMD21319.1 - 0.074 12.5 0.1 1.2 8.5 0.0 2.4 2 1 1 3 3 3 0 BtpA family ThiG PF05690.14 AMD21319.1 - 0.1 11.9 0.2 0.25 10.6 0.0 1.7 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG NMO PF03060.15 AMD21319.1 - 0.1 11.9 0.1 7.1 5.9 0.0 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase DAHP_synth_1 PF00793.20 AMD21320.1 - 3.6e-107 357.3 0.0 4.3e-107 357.1 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Arrestin_N PF00339.29 AMD21321.1 - 0.023 14.7 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Homeobox_KN PF05920.11 AMD21322.1 - 7.3e-19 67.4 1.1 1.4e-18 66.5 1.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 AMD21322.1 - 2.4e-06 27.3 0.4 5.8e-06 26.1 0.4 1.7 1 0 0 1 1 1 1 Homeodomain RasGEF_N PF00618.20 AMD21322.1 - 0.032 14.5 0.3 0.076 13.3 0.0 1.7 2 0 0 2 2 2 0 RasGEF N-terminal motif RRM_1 PF00076.22 AMD21323.1 - 1.6e-15 56.7 0.0 2.4e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelP_N PF04592.14 AMD21323.1 - 2.1 7.7 11.4 3.2 7.1 11.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Metallophos PF00149.28 AMD21324.1 - 6.7e-37 128.0 0.0 1.1e-36 127.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AMD21324.1 - 2.3e-16 59.9 0.5 5.5e-16 58.7 0.0 1.9 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain PHD PF00628.29 AMD21325.1 - 1.1e-09 38.0 6.6 2e-09 37.2 6.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 AMD21325.1 - 0.34 10.5 5.2 0.55 9.8 5.2 1.4 1 0 0 1 1 1 0 PHD-finger Sec1 PF00995.23 AMD21326.1 - 2.8e-112 376.8 11.1 3.3e-112 376.6 11.1 1.0 1 0 0 1 1 1 1 Sec1 family CHASE9 PF17153.4 AMD21326.1 - 0.082 13.1 0.2 0.34 11.1 0.1 2.1 1 1 1 2 2 2 0 Periplasmic sensor domain, extracellular TCO89 PF10452.9 AMD21327.1 - 2e-99 334.2 43.3 1.3e-73 249.0 23.9 2.2 1 1 1 2 2 2 2 TORC1 subunit TCO89 UCH_1 PF13423.6 AMD21328.1 - 2.2e-73 247.6 5.5 3.4e-73 247.0 5.5 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 AMD21328.1 - 5.6e-22 79.0 0.0 1.4e-21 77.8 0.0 1.7 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 AMD21328.1 - 2.4e-08 33.8 2.3 2.4e-08 33.8 2.3 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 AMD21329.1 - 2.3e-19 69.4 13.1 5.3e-07 30.2 0.0 9.7 9 0 0 9 9 9 5 WD domain, G-beta repeat Ribosomal_L36 PF00444.18 AMD21330.1 - 4e-20 71.7 6.9 5e-20 71.4 6.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.17 AMD21330.1 - 0.012 15.4 1.2 0.016 15.0 1.2 1.2 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family DUF3398 PF11878.8 AMD21330.1 - 0.15 12.5 0.0 0.16 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) Spc7 PF08317.11 AMD21331.1 - 2.1e-62 210.8 8.3 3.4e-62 210.1 8.3 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein LRS4 PF10422.9 AMD21331.1 - 0.012 15.3 4.6 0.039 13.5 4.6 2.0 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DivIC PF04977.15 AMD21331.1 - 0.034 13.9 0.7 0.034 13.9 0.7 2.9 3 0 0 3 3 3 0 Septum formation initiator Tup_N PF08581.10 AMD21331.1 - 0.28 11.5 12.6 0.74 10.2 4.2 3.2 2 0 0 2 2 2 0 Tup N-terminal BLOC1_2 PF10046.9 AMD21331.1 - 0.31 11.4 15.6 0.31 11.4 0.8 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 AMD21331.1 - 0.4 10.7 8.1 0.15 12.1 3.8 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4200 PF13863.6 AMD21331.1 - 0.45 10.9 12.7 0.35 11.3 8.4 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) TPR_MLP1_2 PF07926.12 AMD21331.1 - 3.1 7.9 10.3 0.13 12.3 2.5 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 AMD21331.1 - 8.4 6.5 11.7 0.42 10.6 1.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Nucleoporin2 PF04096.14 AMD21332.1 - 5e-46 156.5 0.0 4e-45 153.6 0.0 2.4 2 0 0 2 2 2 1 Nucleoporin autopeptidase Nup96 PF12110.8 AMD21332.1 - 3e-36 125.0 1.1 2.1e-35 122.2 1.1 2.0 1 1 0 1 1 1 1 Nuclear protein 96 Nucleoporin_FG PF13634.6 AMD21332.1 - 4.1e-09 37.2 88.2 5.1e-07 30.4 37.7 3.9 1 1 3 4 4 4 4 Nucleoporin FG repeat region ParA PF10609.9 AMD21333.1 - 7.1e-95 317.1 0.0 8.8e-95 316.8 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 AMD21333.1 - 3e-08 33.8 0.0 1.3e-07 31.7 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AMD21333.1 - 3.8e-07 30.2 0.2 3e-06 27.3 0.2 2.0 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 AMD21333.1 - 1.6e-06 27.6 0.0 3.3e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.15 AMD21333.1 - 2.1e-06 27.1 0.6 0.00015 21.1 0.1 2.9 1 1 1 3 3 3 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 AMD21333.1 - 0.012 15.1 0.1 0.037 13.5 0.1 1.9 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ RsgA_GTPase PF03193.16 AMD21333.1 - 0.013 15.4 0.1 0.053 13.4 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Fer4_NifH PF00142.18 AMD21333.1 - 0.075 12.5 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Rad17 PF03215.15 AMD21333.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_26 PF13500.6 AMD21333.1 - 0.13 12.1 0.0 2.9 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AMD21333.1 - 0.19 11.3 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain XRCC4 PF06632.12 AMD21334.1 - 0.015 14.2 0.7 0.015 14.2 0.7 1.9 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 RRM_1 PF00076.22 AMD21335.1 - 2.8e-26 91.1 4.0 3.1e-06 26.9 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AMD21335.1 - 1.5e-10 40.8 0.1 0.038 13.8 0.0 4.4 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM_5 PF13893.6 AMD21335.1 - 6.8e-05 22.5 0.1 0.088 12.4 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AMD21335.1 - 0.014 15.4 0.4 1.8 8.7 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.6 AMD21335.1 - 0.14 12.2 0.0 14 5.8 0.1 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif MF_alpha_N PF05436.11 AMD21336.1 - 7.6e-13 48.2 0.1 1.4e-12 47.3 0.1 1.4 1 1 0 1 1 1 1 Mating factor alpha precursor N-terminus PMT_4TMC PF16192.5 AMD21336.1 - 0.27 10.8 12.6 8.3 5.9 0.2 4.0 1 1 3 4 4 4 0 C-terminal four TMM region of protein-O-mannosyltransferase IBV_3B PF03622.13 AMD21336.1 - 5.5 7.2 11.2 56 4.0 0.2 4.0 1 1 3 4 4 4 0 IBV 3B protein NAD_kinase PF01513.21 AMD21337.1 - 2.6e-53 181.1 0.0 3.5e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 AMD21337.1 - 0.018 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain UQ_con PF00179.26 AMD21338.1 - 7.2e-17 61.3 0.0 7.7e-17 61.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 AMD21338.1 - 0.11 12.8 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 RWD domain MAD PF05557.13 AMD21339.1 - 6.4e-28 97.5 83.9 8.4e-28 97.1 83.9 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein SNase PF00565.17 AMD21340.1 - 1.4e-23 83.4 0.0 2.2e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue MBOAT PF03062.19 AMD21341.1 - 3.2e-66 224.1 19.9 3.2e-66 224.1 19.9 1.7 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Pkinase PF00069.25 AMD21342.1 - 1.2e-19 70.7 0.0 3.3e-19 69.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21342.1 - 9.1e-11 41.5 0.0 2.9e-10 39.9 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase ParcG PF10274.9 AMD21342.1 - 0.058 13.5 0.9 0.13 12.4 0.2 1.8 2 0 0 2 2 2 0 Parkin co-regulated protein COA2 PF17051.5 AMD21343.1 - 8.8e-15 54.5 0.0 9.2e-15 54.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 RRM_1 PF00076.22 AMD21344.1 - 5.5e-10 38.9 0.2 1.2e-09 37.9 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AMD21344.1 - 3.9e-05 23.2 0.0 0.00026 20.6 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LMBR1 PF04791.16 AMD21344.1 - 7.1 5.4 5.4 11 4.8 5.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein MINDY_DUB PF04424.13 AMD21345.1 - 1.3e-31 109.0 0.3 2.7e-31 108.0 0.0 1.7 2 0 0 2 2 2 1 MINDY deubiquitinase IMD PF08397.11 AMD21345.1 - 0.27 10.6 6.6 0.48 9.8 5.0 2.0 2 0 0 2 2 2 0 IRSp53/MIM homology domain FHA PF00498.26 AMD21346.1 - 2e-05 24.8 0.2 4.1e-05 23.8 0.2 1.4 1 0 0 1 1 1 1 FHA domain TMPIT PF07851.13 AMD21347.1 - 0.018 14.3 0.3 0.021 14.1 0.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein NUFIP1 PF10453.9 AMD21348.1 - 9.6e-18 63.8 1.9 2.6e-17 62.4 1.9 1.8 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) MPC PF03650.13 AMD21349.1 - 9.9e-41 138.3 0.1 1.2e-40 138.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Rad9 PF04139.13 AMD21350.1 - 1e-13 51.3 3.3 1.3e-12 47.7 3.3 2.1 1 1 0 1 1 1 1 Rad9 MetallophosC PF16370.5 AMD21350.1 - 0.096 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase Adaptin_N PF01602.20 AMD21351.1 - 1.9e-114 383.1 17.2 2.7e-114 382.6 17.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AMD21351.1 - 3.5e-10 40.1 11.6 5e-09 36.4 0.7 3.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD21351.1 - 1.2e-05 25.6 0.1 0.5 10.8 0.0 4.9 4 1 1 5 5 5 2 HEAT repeats Cnd3 PF12719.7 AMD21351.1 - 0.00012 21.4 4.8 0.16 11.1 0.1 3.7 1 1 2 3 3 3 2 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 AMD21351.1 - 0.0011 19.0 2.6 17 6.0 0.0 5.9 7 0 0 7 7 7 1 HEAT repeat AP3D1 PF06375.11 AMD21351.1 - 0.0067 16.7 1.2 0.0067 16.7 1.2 3.1 1 1 1 3 3 3 1 AP-3 complex subunit delta-1 DBD_HTH PF18430.1 AMD21351.1 - 0.034 13.9 0.1 0.13 12.1 0.1 2.0 1 0 0 1 1 1 0 Putative DNA-binding domain RasGEF_N_2 PF14663.6 AMD21351.1 - 0.069 13.6 0.8 5.3 7.5 0.1 3.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain KxDL PF10241.9 AMD21352.1 - 3.7e-20 72.0 0.0 6.6e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein TLD PF07534.16 AMD21353.1 - 1.8e-28 99.5 0.0 1.3e-27 96.8 0.0 1.9 1 1 0 1 1 1 1 TLD FA_desaturase PF00487.24 AMD21354.1 - 1.1e-31 110.7 21.4 1.6e-31 110.1 21.4 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 AMD21354.1 - 4.9e-10 39.4 0.0 1.3e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DEAD PF00270.29 AMD21355.1 - 2.8e-54 183.6 0.1 4.4e-53 179.6 0.0 2.7 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21355.1 - 3.7e-35 120.6 0.8 7e-31 106.9 0.1 3.4 2 1 1 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 AMD21355.1 - 2.6e-08 34.0 0.0 2.6e-08 34.0 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 AMD21355.1 - 0.0074 15.1 0.2 0.0074 15.1 0.2 3.6 3 2 1 4 4 4 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 AMD21355.1 - 0.0078 15.6 0.0 0.0078 15.6 0.0 3.6 2 1 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Ndc1_Nup PF09531.10 AMD21355.1 - 2.4 6.7 8.0 3.3 6.3 8.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AAA_22 PF13401.6 AMD21355.1 - 3.4 7.9 5.1 1.6 9.0 1.0 2.5 2 1 0 2 2 2 0 AAA domain Presenilin PF01080.17 AMD21355.1 - 5.1 5.7 20.6 7.6 5.2 20.6 1.2 1 0 0 1 1 1 0 Presenilin AA_permease_2 PF13520.6 AMD21356.1 - 1.7e-51 175.4 53.8 2e-51 175.2 53.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AMD21356.1 - 2.8e-20 72.4 46.2 3.8e-20 72.0 46.2 1.0 1 0 0 1 1 1 1 Amino acid permease DUF3875 PF12991.7 AMD21356.1 - 0.18 11.8 0.7 39 4.3 0.1 3.2 4 0 0 4 4 4 0 Domain of unknown function, B. Theta Gene description (DUF3875) Ribosomal_L30_N PF08079.12 AMD21357.1 - 4.9e-19 68.3 18.7 1e-18 67.3 18.7 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 AMD21357.1 - 3.3e-18 65.3 2.1 7.7e-18 64.1 2.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L37 PF08561.10 AMD21357.1 - 0.93 10.0 7.1 1.6 9.2 7.1 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 DUF3391 PF11871.8 AMD21357.1 - 9.1 6.8 8.2 13 6.3 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) MPS2 PF17060.5 AMD21358.1 - 1.2e-41 143.3 8.7 3.4e-25 89.1 3.9 2.2 1 1 1 2 2 2 2 Monopolar spindle protein 2 HIG_1_N PF04588.13 AMD21358.1 - 0.043 14.0 0.1 0.074 13.3 0.1 1.3 1 0 0 1 1 1 0 Hypoxia induced protein conserved region ADIP PF11559.8 AMD21358.1 - 0.05 13.7 1.0 0.12 12.5 1.0 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding EF-hand_7 PF13499.6 AMD21358.1 - 0.076 13.5 0.1 0.21 12.0 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair DUF5601 PF18151.1 AMD21358.1 - 0.085 13.2 2.0 0.62 10.4 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5601) DUF777 PF05606.11 AMD21358.1 - 0.13 12.1 3.3 6.2 6.6 0.3 2.4 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF777) GPHH PF16905.5 AMD21358.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated RNase_J_C PF17770.1 AMD21358.1 - 0.49 11.5 3.3 2.3 9.3 0.0 3.2 4 0 0 4 4 4 0 Ribonuclease J C-terminal domain DivIC PF04977.15 AMD21358.1 - 1.1 9.1 7.2 0.56 10.0 0.5 2.7 3 0 0 3 3 3 0 Septum formation initiator DUF148 PF02520.17 AMD21358.1 - 3.3 7.9 8.8 3.5 7.8 0.4 3.1 2 2 0 2 2 2 0 Domain of unknown function DUF148 HSF_DNA-bind PF00447.17 AMD21359.1 - 1.6e-32 112.0 2.6 3.8e-32 110.8 2.6 1.7 1 0 0 1 1 1 1 HSF-type DNA-binding PAC2 PF09754.9 AMD21359.1 - 0.081 12.9 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 PAC2 family eIF2A PF08662.11 AMD21360.1 - 3e-05 24.0 0.0 5.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A AFT PF08731.11 AMD21361.1 - 4.1e-45 152.7 3.1 4.1e-45 152.7 3.1 2.3 3 0 0 3 3 3 1 Transcription factor AFT DBD_Tnp_Mut PF03108.15 AMD21361.1 - 0.1 12.6 1.0 17 5.4 0.0 2.5 2 0 0 2 2 2 0 MuDR family transposase RNA_POL_M_15KD PF02150.16 AMD21362.1 - 8.1e-16 57.6 3.4 8.1e-16 57.6 3.4 2.7 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 AMD21362.1 - 6e-14 51.6 14.4 1.2e-13 50.7 1.4 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DUF2387 PF09526.10 AMD21362.1 - 0.0069 16.5 4.0 1.6 9.0 0.4 2.4 2 1 0 2 2 2 2 Probable metal-binding protein (DUF2387) zinc_ribbon_10 PF10058.9 AMD21362.1 - 0.022 14.5 4.5 0.3 10.9 0.1 2.5 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 AMD21362.1 - 0.14 12.2 7.1 1.1 9.3 0.5 2.6 2 1 0 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 AMD21362.1 - 0.78 9.8 11.2 1.8 8.6 2.5 2.4 2 1 0 2 2 2 0 Transposase zinc-ribbon domain HypA PF01155.19 AMD21362.1 - 1.2 9.2 6.2 1.9 8.5 3.2 2.6 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 AMD21362.1 - 2.8 8.4 6.9 1 9.8 0.3 2.6 2 1 0 2 2 2 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 AMD21362.1 - 3.9 7.7 12.4 2.5 8.3 0.1 3.6 3 1 1 4 4 4 0 Zinc ribbon domain Ribosomal_L12 PF00542.19 AMD21363.1 - 3.5e-22 78.5 6.0 3.5e-22 78.5 6.0 2.9 3 0 0 3 3 3 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 AMD21363.1 - 3.3e-13 49.1 2.9 3.1e-12 46.0 0.1 2.8 2 1 1 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain DUF2267 PF10025.9 AMD21363.1 - 0.012 15.9 0.1 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) Bac_DNA_binding PF00216.21 AMD21363.1 - 0.04 14.1 5.1 0.25 11.5 0.7 2.5 1 1 1 2 2 2 0 Bacterial DNA-binding protein Pkinase PF00069.25 AMD21364.1 - 1.8e-71 240.6 0.0 2.2e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21364.1 - 1.9e-39 135.5 0.0 2.3e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD21364.1 - 1e-05 25.0 0.2 2.9e-05 23.5 0.0 1.7 2 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 AMD21364.1 - 0.014 15.0 0.1 0.68 9.5 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 AMD21364.1 - 0.042 12.8 0.3 0.068 12.1 0.3 1.4 1 1 0 1 1 1 0 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 AMD21364.1 - 0.06 12.9 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 AMD21364.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 AMD21364.1 - 0.12 11.9 0.1 0.39 10.3 0.1 1.9 1 1 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 AMD21364.1 - 0.15 11.1 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.25 AMD21365.1 - 6.5e-23 81.4 1.8 7.6e-23 81.2 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21365.1 - 1.9e-14 53.6 0.1 6.8e-14 51.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD21365.1 - 4.9e-08 32.2 0.1 4.9e-08 32.2 0.1 2.8 2 1 1 3 3 3 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 AMD21365.1 - 0.058 12.4 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Flocculin PF00624.18 AMD21366.1 - 3.8e-182 590.3 659.0 5.5e-11 42.5 20.9 24.3 24 0 0 24 24 24 24 Flocculin repeat GLEYA PF10528.9 AMD21366.1 - 1.7e-22 79.6 2.6 1.7e-22 79.6 2.6 6.1 4 2 6 11 11 11 1 GLEYA domain PA14 PF07691.12 AMD21366.1 - 5.2e-12 45.8 0.1 9.9e-11 41.6 0.0 3.3 2 0 0 2 2 2 1 PA14 domain 7TMR-HDED PF07697.11 AMD21366.1 - 0.21 11.7 8.3 2.7 8.1 0.2 3.5 3 0 0 3 3 3 0 7TM-HD extracellular PnpCD_PnpD_N PF18191.1 AMD21366.1 - 5.2 6.6 22.3 10 5.7 0.2 7.2 2 1 9 12 12 12 0 Hydroquinone 1,2-dioxygenase large subunit N-terminal GDPD PF03009.17 AMD21367.1 - 2e-28 99.9 0.5 3.8e-21 76.0 0.1 2.1 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 AMD21367.1 - 0.029 14.8 0.2 0.16 12.4 0.1 2.2 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family SBP_bac_1 PF01547.25 AMD21367.1 - 0.068 13.1 0.1 3.4 7.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein SCA7 PF08313.12 AMD21368.1 - 7.3e-30 102.7 1.0 2.5e-29 101.0 1.0 1.9 1 0 0 1 1 1 1 SCA7, zinc-binding domain zf_C2H2_13 PF18508.1 AMD21368.1 - 2.2e-12 46.4 0.4 4.9e-12 45.2 0.4 1.6 1 0 0 1 1 1 1 Zinc finger domain Glycos_transf_1 PF00534.20 AMD21369.1 - 5e-29 101.0 0.1 2e-28 99.1 0.0 2.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AMD21369.1 - 1.9e-14 54.1 0.0 2.8e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 AMD21369.1 - 2.4e-09 37.7 0.0 2e-08 34.7 0.0 2.4 2 1 0 2 2 2 1 Glycosyl transferases group 1 ALG11_N PF15924.5 AMD21369.1 - 0.0074 16.4 1.7 2.9 7.9 0.3 3.3 1 1 2 3 3 3 2 ALG11 mannosyltransferase N-terminus Glyco_trans_4_4 PF13579.6 AMD21369.1 - 0.0087 16.5 0.0 0.015 15.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_5 PF16994.5 AMD21369.1 - 0.017 14.7 0.0 0.086 12.4 0.0 2.0 2 0 0 2 2 2 0 Glycosyl-transferase family 4 IncD PF17628.2 AMD21369.1 - 0.1 12.4 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Inclusion membrane protein D Wyosine_form PF08608.12 AMD21370.1 - 9.1e-22 77.2 0.0 2.1e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 AMD21370.1 - 3.6e-21 76.3 0.0 1.2e-20 74.6 0.0 2.0 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 AMD21370.1 - 7.2e-15 55.5 0.0 1.8e-14 54.1 0.0 1.7 1 1 0 1 1 1 1 Flavodoxin SET PF00856.28 AMD21371.1 - 3.3e-08 34.1 0.0 9.7e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 SET domain BCA_ABC_TP_C PF12399.8 AMD21371.1 - 0.0045 16.9 0.2 0.0096 15.8 0.2 1.6 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AstE_AspA PF04952.14 AMD21371.1 - 0.054 12.6 0.0 0.088 11.9 0.0 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Pkinase PF00069.25 AMD21372.1 - 7.5e-71 238.6 0.0 1.1e-70 238.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21372.1 - 1.7e-44 152.0 0.0 2.3e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1461 PF07314.11 AMD21372.1 - 0.002 18.1 0.3 0.0032 17.4 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1461) Kinase-like PF14531.6 AMD21372.1 - 0.0022 17.4 0.0 0.0034 16.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 AMD21372.1 - 0.0063 16.1 0.4 0.029 14.0 0.1 2.1 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 AMD21372.1 - 0.042 13.2 0.0 0.12 11.7 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 AMD21372.1 - 0.067 11.9 0.2 0.085 11.6 0.2 1.4 1 1 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 AMD21372.1 - 0.09 12.4 0.1 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DEAD PF00270.29 AMD21373.1 - 1.1e-33 116.5 0.2 3.4e-33 114.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21373.1 - 5.9e-20 71.7 1.7 3.2e-19 69.3 0.3 2.8 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD21373.1 - 1.1e-11 45.1 0.3 1.5e-10 41.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 AMD21373.1 - 6.7e-06 25.0 0.2 1.1e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4830 PF16112.5 AMD21373.1 - 0.091 13.2 0.0 0.54 10.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4830) SRP72 PF08492.12 AMD21374.1 - 2.7e-14 53.3 3.8 2.7e-14 53.3 3.8 2.0 2 0 0 2 2 1 1 SRP72 RNA-binding domain TPR_2 PF07719.17 AMD21374.1 - 9.1e-06 25.4 1.1 1.7 9.0 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 AMD21374.1 - 0.00025 21.6 1.6 10 7.3 0.3 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 AMD21374.1 - 0.00025 21.5 0.5 4.6 8.1 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 AMD21374.1 - 0.00038 20.9 5.9 1.1 9.8 1.1 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD21374.1 - 0.0088 16.3 6.9 1.4 9.3 0.6 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 AMD21374.1 - 0.049 13.6 9.2 3.5 7.7 3.8 4.1 3 1 0 3 3 3 0 Putative TPR-like repeat TPR_8 PF13181.6 AMD21374.1 - 0.055 13.7 3.3 31 5.1 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 AMD21374.1 - 0.065 13.3 2.9 4 7.7 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC5 PF12862.7 AMD21374.1 - 0.094 12.8 1.8 0.34 11.0 0.8 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_4 PF07721.14 AMD21374.1 - 0.21 12.3 0.3 0.51 11.1 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2225 PF09986.9 AMD21374.1 - 0.7 9.6 6.3 0.47 10.2 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) UPF0113_N PF17833.1 AMD21375.1 - 5.8e-29 100.5 0.1 8.7e-29 99.9 0.1 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 AMD21375.1 - 8.5e-26 90.0 0.0 1.7e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain PseudoU_synth_1 PF01416.20 AMD21376.1 - 1.8e-12 47.7 0.0 5.2e-11 43.0 0.0 2.6 2 0 0 2 2 2 1 tRNA pseudouridine synthase DUF2344 PF10105.9 AMD21376.1 - 0.036 13.9 0.0 0.44 10.4 0.0 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) DAP3 PF10236.9 AMD21377.1 - 1.2e-71 241.5 0.4 1.6e-71 241.0 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 AMD21377.1 - 6.9e-08 33.1 0.0 1.4e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 AMD21377.1 - 0.00029 20.8 0.0 0.00096 19.1 0.0 1.9 2 0 0 2 2 2 1 NTPase AAA_22 PF13401.6 AMD21377.1 - 0.0013 19.0 0.2 0.012 15.9 0.0 2.6 2 1 0 2 2 1 1 AAA domain AAA_7 PF12775.7 AMD21377.1 - 0.0031 17.0 0.0 0.0067 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region MeaB PF03308.16 AMD21377.1 - 0.005 15.9 0.9 0.0065 15.5 0.1 1.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 AMD21377.1 - 0.0055 16.6 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_29 PF13555.6 AMD21377.1 - 0.0075 16.0 0.0 0.023 14.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AMD21377.1 - 0.0079 16.1 0.1 0.023 14.6 0.1 1.8 1 1 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 AMD21377.1 - 0.023 14.4 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AMD21377.1 - 0.032 13.4 0.0 0.062 12.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain IstB_IS21 PF01695.17 AMD21377.1 - 0.035 13.8 0.0 0.095 12.4 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 AMD21377.1 - 0.048 14.2 0.0 0.26 11.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 AMD21377.1 - 0.048 13.4 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Alpha-amylase PF00128.24 AMD21377.1 - 0.081 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Alpha amylase, catalytic domain AAA_25 PF13481.6 AMD21377.1 - 0.12 12.0 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain mRNA_cap_enzyme PF01331.19 AMD21378.1 - 2.8e-59 200.2 0.0 4.8e-59 199.5 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 AMD21378.1 - 4.2e-32 111.0 0.2 7.9e-32 110.1 0.2 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 AMD21378.1 - 4.1e-07 29.8 0.0 4.1e-05 23.3 0.0 2.5 1 1 0 1 1 1 1 ATP dependent DNA ligase domain BAH PF01426.18 AMD21379.1 - 2.5e-17 62.8 0.6 8.3e-17 61.2 0.2 2.1 2 0 0 2 2 2 1 BAH domain zf-HC5HC2H_2 PF13832.6 AMD21379.1 - 5.7e-14 52.2 1.0 5.7e-14 52.2 1.0 5.3 5 1 0 5 5 5 2 PHD-zinc-finger like domain PHD PF00628.29 AMD21379.1 - 2.2e-13 49.9 56.9 6.3e-07 29.2 9.7 5.7 5 1 1 6 6 6 3 PHD-finger zf-HC5HC2H PF13771.6 AMD21379.1 - 5.3e-09 36.2 1.3 5.3e-09 36.2 1.3 5.5 5 1 1 6 6 6 2 PHD-like zinc-binding domain PHD_2 PF13831.6 AMD21379.1 - 5.7e-08 32.2 23.3 1.2e-06 27.9 5.7 4.7 4 0 0 4 4 4 3 PHD-finger Myb_DNA-binding PF00249.31 AMD21379.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain EELM2 PF15863.5 AMD21379.1 - 0.031 14.4 1.4 9.3 6.3 0.0 3.7 3 1 1 4 4 4 0 Extended EGL-27 and MTA1 homology domain LRR_9 PF14580.6 AMD21380.1 - 2e-12 47.0 0.8 2e-12 47.0 0.8 1.8 2 1 1 3 3 3 1 Leucine-rich repeat LRR_4 PF12799.7 AMD21380.1 - 0.0012 19.2 14.8 0.025 15.0 4.8 3.8 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AMD21380.1 - 0.12 12.2 10.3 0.64 9.8 5.0 3.1 2 1 0 2 2 2 0 Leucine rich repeat LRR_6 PF13516.6 AMD21380.1 - 8.4 6.7 9.8 29 5.1 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat HK PF02110.15 AMD21381.1 - 1.9e-82 276.4 1.0 2.7e-82 275.9 1.0 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 AMD21381.1 - 3.2e-60 202.5 0.0 5.3e-60 201.8 0.0 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 AMD21381.1 - 0.047 13.1 0.4 0.41 10.0 0.4 2.1 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase Ubiq_cyt_C_chap PF03981.12 AMD21382.1 - 5.1e-41 140.1 0.2 7.4e-41 139.5 0.2 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone WAC_Acf1_DNA_bd PF10537.9 AMD21383.1 - 1.4e-34 118.6 1.4 1.4e-34 118.6 1.4 2.4 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.17 AMD21383.1 - 3.3e-10 40.1 3.3 2.4e-08 34.1 0.4 2.9 2 0 0 2 2 2 2 DDT domain WSD PF15613.6 AMD21383.1 - 7.8e-10 39.1 2.5 5.3e-09 36.5 0.1 3.6 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif WHIM1 PF15612.6 AMD21383.1 - 0.022 14.3 0.0 0.055 13.0 0.0 1.7 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 RIBIOP_C PF04950.12 AMD21384.1 - 7.4e-87 291.5 0.1 7.4e-87 291.5 0.1 2.6 2 1 1 3 3 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 AMD21384.1 - 1.6e-27 95.4 0.0 7.6e-27 93.2 0.0 2.3 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_16 PF13191.6 AMD21384.1 - 1.3e-06 28.9 0.1 7.2e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 AMD21384.1 - 3.4e-06 27.3 0.0 1.7e-05 25.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 AMD21384.1 - 1e-05 25.2 0.0 0.0039 16.8 0.0 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 AMD21384.1 - 1.7e-05 25.2 0.1 5.9e-05 23.5 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD21384.1 - 1.9e-05 24.9 0.1 8.7e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AMD21384.1 - 0.0014 18.7 0.5 0.012 15.7 0.1 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 AMD21384.1 - 0.0017 18.3 0.0 0.0038 17.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_28 PF13521.6 AMD21384.1 - 0.004 17.4 0.0 0.015 15.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AMD21384.1 - 0.005 16.7 0.0 0.005 16.7 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_5 PF07728.14 AMD21384.1 - 0.0054 16.7 0.1 0.018 15.1 0.1 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 AMD21384.1 - 0.0056 17.2 0.8 0.026 15.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_30 PF13604.6 AMD21384.1 - 0.0061 16.3 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD21384.1 - 0.007 16.9 0.0 0.007 16.9 0.0 3.3 4 0 0 4 4 2 1 AAA domain AAA_19 PF13245.6 AMD21384.1 - 0.0083 16.5 0.2 0.02 15.3 0.2 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 AMD21384.1 - 0.014 15.7 0.0 0.04 14.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 AMD21384.1 - 0.021 14.4 0.0 0.061 12.8 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 AMD21384.1 - 0.024 14.5 0.3 0.049 13.5 0.3 1.5 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 AMD21384.1 - 0.026 13.7 0.0 0.058 12.6 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain MobB PF03205.14 AMD21384.1 - 0.033 14.1 0.2 0.12 12.2 0.1 2.0 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 AMD21384.1 - 0.039 13.5 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 AMD21384.1 - 0.063 12.9 0.1 0.063 12.9 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 AMD21385.1 - 6.6e-66 221.1 0.0 7.5e-66 220.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 AMD21385.1 - 1.7e-08 34.1 0.3 2.2e-05 23.8 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 AMD21385.1 - 5.6e-08 32.5 0.0 6.6e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 AMD21385.1 - 3.7e-07 29.7 0.0 4.8e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AMD21385.1 - 1.3e-06 28.6 0.0 4.1e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AMD21385.1 - 9.4e-06 25.7 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AMD21385.1 - 0.00014 21.3 0.0 0.00015 21.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AMD21385.1 - 0.0085 15.6 0.0 0.12 11.9 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 AMD21385.1 - 0.14 11.9 0.0 0.46 10.2 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Cyclin PF08613.11 AMD21386.1 - 1.2e-11 45.2 0.2 2.3e-11 44.3 0.2 1.4 1 0 0 1 1 1 1 Cyclin Ribosomal_L1 PF00687.21 AMD21387.1 - 1.9e-42 145.3 0.6 2.3e-42 145.0 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family FtsJ PF01728.19 AMD21388.1 - 3.2e-53 180.5 0.0 4.1e-53 180.1 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 AMD21388.1 - 1.8e-05 24.6 0.0 0.0073 16.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 AMD21388.1 - 0.00076 19.4 0.0 0.008 16.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD21388.1 - 0.12 13.1 0.0 0.6 10.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Coatomer_WDAD PF04053.14 AMD21389.1 - 2.6e-163 544.2 0.1 4.3e-162 540.2 0.0 2.0 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 AMD21389.1 - 4.9e-36 122.1 4.0 3.2e-06 27.8 0.0 8.4 8 1 1 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21389.1 - 7.6e-08 32.6 0.0 0.22 11.9 0.0 6.5 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 AMD21389.1 - 7.9e-05 22.7 0.3 0.38 10.8 0.0 4.7 1 1 4 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 AMD21389.1 - 0.00016 20.5 4.7 0.096 11.3 0.0 3.7 3 1 2 5 5 5 2 Nucleoporin Nup120/160 MetallophosC PF16370.5 AMD21389.1 - 0.018 15.3 0.0 0.17 12.1 0.0 2.7 3 1 1 4 4 4 0 C terminal of Calcineurin-like phosphoesterase PQQ PF01011.21 AMD21389.1 - 0.14 12.1 3.7 4 7.5 0.3 3.6 4 0 0 4 4 4 0 PQQ enzyme repeat TPR_2 PF07719.17 AMD21389.1 - 0.14 12.3 0.1 0.14 12.3 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 AMD21389.1 - 0.62 10.0 2.9 0.82 9.6 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TRP PF06011.12 AMD21391.1 - 4.9e-146 486.8 36.4 5.8e-146 486.5 36.4 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 AMD21391.1 - 5.2e-39 133.8 0.2 8.6e-39 133.1 0.2 1.4 1 0 0 1 1 1 1 ML-like domain ECSCR PF15820.5 AMD21391.1 - 0.037 13.8 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator UPF0061 PF02696.14 AMD21393.1 - 9.7e-141 469.7 0.0 1.2e-140 469.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family GCR1_C PF12550.8 AMD21394.1 - 1.2e-23 83.2 2.0 2.3e-23 82.3 2.0 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Peptidase_M17 PF00883.21 AMD21394.1 - 8.7e-05 21.9 0.1 0.052 12.8 0.0 2.3 2 0 0 2 2 2 2 Cytosol aminopeptidase family, catalytic domain Imm7 PF15585.6 AMD21394.1 - 0.078 13.3 0.1 0.18 12.1 0.1 1.6 1 0 0 1 1 1 0 Immunity protein 7 SlyX PF04102.12 AMD21394.1 - 0.14 12.8 2.1 0.31 11.7 2.1 1.6 1 0 0 1 1 1 0 SlyX JmjC PF02373.22 AMD21396.1 - 4.5e-17 62.5 0.0 8.7e-08 32.6 0.0 3.0 2 0 0 2 2 2 2 JmjC domain, hydroxylase ARID PF01388.21 AMD21396.1 - 4.9e-15 56.0 0.3 1.2e-13 51.6 0.0 3.2 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain PLU-1 PF08429.11 AMD21396.1 - 1.8e-13 50.4 0.1 3.9e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 PLU-1-like protein PHD PF00628.29 AMD21396.1 - 7.3e-07 29.0 5.5 1.6e-06 27.9 5.5 1.6 1 0 0 1 1 1 1 PHD-finger Glyco_transf_10 PF00852.19 AMD21396.1 - 0.032 13.9 0.2 0.23 11.2 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase family 10 (fucosyltransferase) C-term PHD_4 PF16866.5 AMD21396.1 - 2 8.5 7.5 0.96 9.6 4.0 2.4 2 0 0 2 2 2 0 PHD-finger Cation_efflux PF01545.21 AMD21397.1 - 2.1e-45 154.9 11.9 2.7e-45 154.6 11.9 1.1 1 0 0 1 1 1 1 Cation efflux family Polysacc_synt_4 PF04669.13 AMD21398.1 - 1.2e-18 67.3 0.8 2.3e-16 59.9 0.8 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis NitrOD1 PF18549.1 AMD21398.1 - 0.059 13.3 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Nitrosopumilus output domain 1 YcbB PF08664.10 AMD21398.1 - 0.082 13.0 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 YcbB domain MoCF_biosynth PF00994.24 AMD21399.1 - 2.1e-33 115.0 0.0 3.4e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain PhetRS_B1 PF18262.1 AMD21399.1 - 0.0078 16.4 0.0 0.022 15.0 0.0 1.8 1 0 0 1 1 1 1 Phe-tRNA synthetase beta subunit B1 domain ABC_tran PF00005.27 AMD21400.1 - 6.4e-46 156.3 0.0 5.9e-25 88.4 0.0 4.2 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AMD21400.1 - 7.2e-13 49.0 2.0 0.0044 16.9 0.8 4.6 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AMD21400.1 - 3.8e-12 46.1 0.0 0.0034 16.9 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 AMD21400.1 - 1.2e-09 37.9 3.5 2.5e-09 36.9 3.5 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 AMD21400.1 - 2.3e-07 31.5 1.3 0.012 16.1 0.0 3.0 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 AMD21400.1 - 5.5e-07 29.7 0.1 0.0073 16.4 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 AMD21400.1 - 1.4e-06 27.9 0.4 0.028 14.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AMD21400.1 - 6.3e-06 26.2 0.0 0.091 12.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 AMD21400.1 - 6.3e-05 23.3 0.3 0.36 11.1 0.2 3.2 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 AMD21400.1 - 0.00022 21.5 0.0 0.13 12.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AMD21400.1 - 0.00072 19.5 0.4 0.2 11.5 0.0 2.6 2 0 0 2 2 2 1 NACHT domain MeaB PF03308.16 AMD21400.1 - 0.00079 18.5 0.1 1 8.3 0.0 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 AMD21400.1 - 0.0029 17.4 3.7 0.55 9.9 0.3 3.3 2 2 1 3 3 3 2 AAA ATPase domain DUF87 PF01935.17 AMD21400.1 - 0.003 17.7 5.3 0.4 10.7 0.1 4.3 4 0 0 4 4 4 1 Helicase HerA, central domain Dynamin_N PF00350.23 AMD21400.1 - 0.0058 16.7 0.2 0.98 9.5 0.0 3.2 2 1 0 2 2 2 1 Dynamin family DUF815 PF05673.13 AMD21400.1 - 0.0064 15.7 0.6 0.36 10.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 AMD21400.1 - 0.0067 16.8 0.1 3 8.3 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_13 PF13166.6 AMD21400.1 - 0.0089 14.7 0.0 1 7.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AMD21400.1 - 0.012 15.8 0.0 8.4 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 AMD21400.1 - 0.013 14.7 0.6 0.38 9.9 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain DUF3584 PF12128.8 AMD21400.1 - 0.021 12.4 0.7 1.9 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_18 PF13238.6 AMD21400.1 - 0.028 15.0 0.5 11 6.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 AMD21400.1 - 0.029 14.1 0.5 2 8.1 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 AMD21400.1 - 0.036 13.8 0.3 14 5.3 0.2 3.0 3 1 0 3 3 2 0 AAA domain Roc PF08477.13 AMD21400.1 - 0.049 13.8 0.0 11 6.3 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 AMD21400.1 - 0.053 13.9 0.1 5.3 7.4 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 AMD21400.1 - 0.06 13.4 0.0 7.1 6.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 AMD21400.1 - 0.06 12.9 0.1 7.2 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 AMD21400.1 - 0.089 12.7 0.0 15 5.5 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA PF00004.29 AMD21400.1 - 0.11 13.0 0.2 17 5.9 0.0 3.6 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 AMD21400.1 - 0.15 12.0 0.2 15 5.6 0.1 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Glycos_transf_2 PF00535.26 AMD21402.1 - 1.1e-25 90.4 0.0 1.9e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AMD21402.1 - 7.7e-08 32.5 0.0 1e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 AMD21402.1 - 3e-05 23.6 0.0 4.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AMD21402.1 - 0.0014 19.1 0.0 0.003 18.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 mRNA_triPase PF02940.15 AMD21403.1 - 2.3e-64 217.2 2.0 3.8e-64 216.4 2.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Tuberin PF03542.16 AMD21404.1 - 0.00029 20.0 1.2 0.00029 20.0 1.2 1.7 2 0 0 2 2 2 1 Tuberin TERB2 PF15101.6 AMD21404.1 - 3.4 7.7 8.6 0.5 10.4 1.6 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Spt20 PF12090.8 AMD21404.1 - 3.7 7.1 26.4 1.2 8.7 12.7 2.1 2 0 0 2 2 2 0 Spt20 family zf-C2H2 PF00096.26 AMD21405.1 - 1.9e-10 40.6 8.1 2.6e-05 24.4 1.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD21405.1 - 1.1e-09 38.3 2.1 1.1e-09 38.3 2.1 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD21405.1 - 5.6e-07 29.9 7.5 0.00047 20.8 0.9 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AMD21405.1 - 0.0011 19.3 3.5 0.025 14.9 0.4 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AMD21405.1 - 0.0064 16.5 0.4 0.019 14.9 0.4 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AMD21405.1 - 0.014 15.6 0.4 0.014 15.6 0.4 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 AMD21405.1 - 0.032 13.9 2.7 1.1 9.0 0.0 3.0 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain BolA PF01722.18 AMD21405.1 - 0.034 14.4 0.6 0.069 13.4 0.6 1.5 1 0 0 1 1 1 0 BolA-like protein zf-C2HE PF16278.5 AMD21405.1 - 0.058 13.9 1.8 0.15 12.6 1.8 1.7 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 AMD21405.1 - 0.079 13.6 0.1 0.17 12.6 0.1 1.6 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats Fas_alpha_ACP PF18325.1 AMD21406.1 - 1.8e-70 236.5 0.2 1.8e-70 236.5 0.2 1.8 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 AMD21406.1 - 3.5e-65 219.4 0.5 3.5e-65 219.4 0.5 2.1 3 0 0 3 3 3 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 AMD21406.1 - 4.2e-21 75.7 0.0 7.8e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 AMD21406.1 - 2.9e-14 53.2 0.0 6.5e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 AMD21406.1 - 2.1e-12 47.1 0.0 7.1e-12 45.4 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 AMD21406.1 - 7e-06 25.6 0.0 1.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AMD21406.1 - 0.00054 19.9 0.0 0.0018 18.2 0.0 1.9 1 0 0 1 1 1 1 KR domain NAD_binding_7 PF13241.6 AMD21406.1 - 0.11 12.9 0.0 0.43 11.1 0.0 2.0 1 0 0 1 1 1 0 Putative NAD(P)-binding DEC-1_N PF04625.13 AMD21406.1 - 8.9 5.2 12.4 17 4.3 12.4 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Syntaxin PF00804.25 AMD21407.1 - 2e-21 76.6 16.2 2e-21 76.6 16.2 2.5 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 AMD21407.1 - 1.5e-11 44.1 3.2 1.5e-11 44.1 3.2 1.9 2 0 0 2 2 2 1 SNARE domain Synaptobrevin PF00957.21 AMD21407.1 - 0.006 16.3 2.6 0.006 16.3 2.6 2.1 2 1 0 2 2 2 1 Synaptobrevin SKA1 PF07160.12 AMD21407.1 - 0.012 15.4 3.0 0.012 15.4 3.0 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 SLATT_5 PF18160.1 AMD21407.1 - 0.013 14.8 0.7 0.022 14.1 0.1 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Thr_dehydrat_C PF00585.18 AMD21407.1 - 0.014 15.1 3.1 0.019 14.7 0.1 2.6 3 0 0 3 3 3 0 C-terminal regulatory domain of Threonine dehydratase DUF948 PF06103.11 AMD21407.1 - 0.028 14.7 3.1 0.028 14.7 3.1 3.4 3 1 0 3 3 2 0 Bacterial protein of unknown function (DUF948) VSG_B PF13206.6 AMD21407.1 - 0.045 13.0 6.4 0.93 8.7 6.7 2.1 2 0 0 2 2 2 0 Trypanosomal VSG domain DUF1759 PF03564.15 AMD21407.1 - 0.17 11.8 5.6 2 8.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1759) DUF1664 PF07889.12 AMD21407.1 - 0.39 10.8 8.5 0.8 9.7 2.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) OppC_N PF12911.7 AMD21407.1 - 0.66 10.0 3.0 1.2 9.2 3.0 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF1676 PF07898.13 AMD21407.1 - 2.5 8.1 7.2 2.3 8.2 4.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1676) XhlA PF10779.9 AMD21407.1 - 3.3 8.0 7.0 0.38 11.0 0.4 2.7 2 1 1 3 3 3 0 Haemolysin XhlA Allexi_40kDa PF05549.11 AMD21407.1 - 6.3 6.2 7.7 2.2 7.7 1.0 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein SlyX PF04102.12 AMD21407.1 - 7.4 7.3 14.5 0.44 11.2 5.0 3.0 2 1 0 2 2 2 0 SlyX Sugar_tr PF00083.24 AMD21408.1 - 2e-109 366.5 25.5 2.4e-109 366.2 25.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD21408.1 - 3.3e-25 88.8 30.9 2e-24 86.2 25.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 AMD21408.1 - 1.1 9.9 7.7 0.12 12.9 2.2 2.3 3 0 0 3 3 3 0 Phage holin family 2 Mis14 PF08641.12 AMD21409.1 - 1.6e-22 80.2 6.2 1.6e-22 80.2 6.2 1.7 2 0 0 2 2 2 1 Kinetochore protein Mis14 like Phage_min_cap2 PF06152.11 AMD21409.1 - 0.031 13.2 2.3 0.32 9.8 0.1 2.3 1 1 1 2 2 2 0 Phage minor capsid protein 2 bVLRF1 PF18826.1 AMD21409.1 - 0.13 12.1 0.3 0.28 11.0 0.2 1.6 1 1 1 2 2 2 0 bacteroidetes VLRF1 release factor ThiS PF02597.20 AMD21409.1 - 0.18 12.4 1.1 0.53 11.0 0.1 2.2 2 1 0 2 2 2 0 ThiS family DUF615 PF04751.14 AMD21409.1 - 0.72 9.8 7.3 1.8 8.5 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF615) Peptidase_M41 PF01434.18 AMD21409.1 - 2.6 7.8 6.6 9.5 6.0 0.3 3.0 1 1 3 4 4 4 0 Peptidase family M41 ATP-synt_C PF00137.21 AMD21410.1 - 3.4e-31 107.4 30.1 2.2e-19 69.6 8.9 2.1 2 0 0 2 2 2 2 ATP synthase subunit C TIP49 PF06068.13 AMD21411.1 - 1.9e-154 514.1 1.5 2.5e-154 513.7 1.5 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 AMD21411.1 - 2.3e-26 91.7 0.8 7.3e-26 90.1 0.7 1.9 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 AMD21411.1 - 8.4e-09 35.9 0.6 8.8e-06 26.2 0.1 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AMD21411.1 - 6.2e-07 29.3 0.5 0.0024 17.6 0.1 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 AMD21411.1 - 2.5e-06 27.0 1.2 3.4e-06 26.6 0.2 1.7 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 AMD21411.1 - 0.00021 21.7 0.3 0.00063 20.2 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AMD21411.1 - 0.00052 20.3 0.0 0.39 11.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 AMD21411.1 - 0.0014 18.2 0.2 0.0032 17.1 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD21411.1 - 0.005 17.2 1.1 0.027 14.8 0.3 2.4 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AMD21411.1 - 0.0063 16.8 0.0 0.017 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AMD21411.1 - 0.03 13.7 1.1 0.2 11.0 0.3 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TFIID_20kDa PF03847.13 AMD21411.1 - 0.032 14.7 0.1 0.088 13.3 0.1 1.7 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A AAA_5 PF07728.14 AMD21411.1 - 0.064 13.2 1.0 2.4 8.2 0.0 3.1 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) Hydin_ADK PF17213.3 AMD21411.1 - 0.073 13.3 1.4 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 AMD21411.1 - 0.079 13.1 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AMD21411.1 - 0.1 13.1 0.0 0.45 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain eIF-5_eIF-2B PF01873.17 AMD21413.1 - 1.9e-38 131.0 0.4 3.4e-38 130.1 0.4 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 AMD21413.1 - 0.028 14.0 0.2 0.07 12.7 0.2 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding IF2_N PF04760.15 AMD21413.1 - 0.033 14.0 2.1 0.11 12.3 0.0 2.9 3 1 1 4 4 4 0 Translation initiation factor IF-2, N-terminal region Tox-REase-2 PF15646.6 AMD21413.1 - 0.14 12.3 0.8 0.35 11.0 0.3 1.9 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 2 DUF2752 PF10825.8 AMD21413.1 - 0.19 11.8 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) Arc_trans_TRASH PF08394.10 AMD21413.1 - 3.4 8.1 6.2 31 5.0 2.4 2.7 1 1 1 2 2 2 0 Archaeal TRASH domain Ank_2 PF12796.7 AMD21414.1 - 6e-17 62.0 0.0 1e-16 61.3 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AMD21414.1 - 1.9e-15 56.7 0.1 3.8e-08 33.5 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 AMD21414.1 - 4.4e-12 45.9 0.1 1.1e-05 25.6 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 AMD21414.1 - 9.1e-12 44.1 0.1 6.3e-05 23.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 AMD21414.1 - 4.5e-11 43.0 0.0 9.1e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) RTP1_C1 PF10363.9 AMD21415.1 - 2.1e-29 102.0 0.1 2.1e-29 102.0 0.1 4.1 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 AMD21415.1 - 0.00012 21.7 0.5 0.00033 20.3 0.5 1.7 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 HEAT_2 PF13646.6 AMD21415.1 - 0.008 16.5 0.1 0.089 13.2 0.0 2.9 3 0 0 3 3 3 1 HEAT repeats CxC1 PF18802.1 AMD21415.1 - 0.17 12.1 0.5 0.75 10.0 0.1 2.3 3 0 0 3 3 3 0 CxC1 like cysteine cluster associated with KDZ transposases HSP90 PF00183.18 AMD21416.1 - 1.6e-218 726.8 32.8 2.2e-218 726.4 32.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 AMD21416.1 - 3e-15 56.7 0.1 7.2e-15 55.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AMD21416.1 - 1.7e-10 40.8 0.0 6.3e-10 39.0 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Tau95 PF09734.9 AMD21416.1 - 5.1 7.9 7.5 1.6 9.5 1.9 2.7 3 0 0 3 3 3 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain TBCC PF07986.12 AMD21417.1 - 2.5e-06 27.2 9.3 2.3e-05 24.1 4.1 2.2 1 1 1 2 2 2 2 Tubulin binding cofactor C RasGAP_C PF03836.15 AMD21418.1 - 7.9e-16 58.5 0.5 2.3e-15 56.9 0.5 1.9 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.19 AMD21418.1 - 5.1e-13 49.2 0.6 1.8e-12 47.4 0.6 2.0 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 AMD21418.1 - 4e-12 46.3 0.0 1.3e-11 44.7 0.0 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain IQ PF00612.27 AMD21418.1 - 6.9e-07 28.5 33.7 0.13 12.1 0.6 10.6 11 0 0 11 11 11 3 IQ calmodulin-binding motif Ribosomal_L32p PF01783.23 AMD21420.1 - 0.027 14.7 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 Ribosomal L32p protein family RINGv PF12906.7 AMD21420.1 - 0.14 12.3 8.6 0.42 10.8 8.6 1.9 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 AMD21420.1 - 0.8 9.9 7.9 2.8 8.2 5.7 2.6 2 0 0 2 2 2 0 FANCL C-terminal domain SRP68 PF16969.5 AMD21421.1 - 1.1e-56 193.1 15.8 1.3e-56 192.8 15.8 1.1 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 DUF2408 PF10303.9 AMD21421.1 - 0.082 13.5 0.1 0.082 13.5 0.1 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) UAA PF08449.11 AMD21422.1 - 6.8e-37 127.3 11.3 8e-37 127.1 11.3 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 AMD21422.1 - 1.7e-10 41.2 6.1 1.7e-10 41.2 6.1 3.0 2 1 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 AMD21422.1 - 4.8e-08 32.7 9.1 1.4e-07 31.2 9.1 2.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family SLC35F PF06027.12 AMD21422.1 - 0.004 16.7 7.5 0.0055 16.2 7.5 1.1 1 0 0 1 1 1 1 Solute carrier family 35 MraZ PF02381.18 AMD21422.1 - 0.13 12.3 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 MraZ protein, putative antitoxin-like Abhydrolase_9_N PF15420.6 AMD21422.1 - 0.15 12.0 3.6 0.053 13.5 0.7 1.7 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Rhomboid PF01694.22 AMD21423.1 - 4.4e-16 59.2 13.1 7e-16 58.6 13.1 1.3 1 0 0 1 1 1 1 Rhomboid family Ribosomal_S17 PF00366.20 AMD21424.1 - 2.7e-24 85.0 6.6 3.3e-24 84.8 2.8 2.4 2 0 0 2 2 2 1 Ribosomal protein S17 WD40 PF00400.32 AMD21425.1 - 4.6e-15 55.8 17.2 7.8e-06 26.5 0.6 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat RQC PF09382.10 AMD21427.1 - 4.2e-26 91.0 0.3 9e-26 89.9 0.3 1.6 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 AMD21427.1 - 1.5e-24 86.5 0.2 5e-18 65.5 0.0 3.7 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 AMD21427.1 - 1.1e-21 77.4 0.0 2.5e-21 76.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 AMD21427.1 - 5.2e-17 62.3 8.2 5.2e-17 62.3 8.2 2.3 2 0 0 2 2 2 1 RecQ zinc-binding Helicase_Sgs1 PF11408.8 AMD21427.1 - 2.3e-09 37.2 0.6 8.8e-09 35.3 0.6 2.0 1 0 0 1 1 1 1 Sgs1 RecQ helicase ResIII PF04851.15 AMD21427.1 - 1.9e-05 24.7 0.0 0.00011 22.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 AMD21427.1 - 0.011 14.5 0.0 0.018 13.8 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain RabGAP-TBC PF00566.18 AMD21428.1 - 2.8e-49 167.7 2.6 3.4e-49 167.4 0.8 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Myb_DNA-bind_4 PF13837.6 AMD21428.1 - 0.091 13.2 1.7 11 6.5 0.1 2.9 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Tropomyosin_1 PF12718.7 AMD21428.1 - 5.2 7.2 25.1 0.12 12.5 3.1 3.0 3 0 0 3 3 3 0 Tropomyosin like Ribosomal_L28 PF00830.19 AMD21429.1 - 1.6e-21 76.3 0.6 3.2e-21 75.3 0.6 1.5 1 0 0 1 1 1 1 Ribosomal L28 family Ribosomal_L36e PF01158.18 AMD21430.1 - 2.2e-37 127.2 2.8 2.5e-37 127.0 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Phage_HK97_TLTM PF06120.11 AMD21431.1 - 0.029 13.6 3.1 0.038 13.2 3.1 1.1 1 0 0 1 1 1 0 Tail length tape measure protein Rsc14 PF08586.10 AMD21431.1 - 0.12 13.2 0.5 0.17 12.7 0.5 1.3 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit V-SNARE PF05008.15 AMD21433.1 - 2.3e-20 72.8 2.8 2.3e-20 72.8 2.8 2.3 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 AMD21433.1 - 1.9e-16 60.1 3.0 1.9e-16 60.1 3.0 3.9 3 1 1 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 AMD21433.1 - 0.00087 19.2 1.6 0.00087 19.2 1.6 2.5 1 1 3 4 4 4 1 Sec20 YqjK PF13997.6 AMD21433.1 - 0.038 14.2 7.7 0.39 11.0 0.1 3.0 3 0 0 3 3 3 0 YqjK-like protein ZnuA PF01297.17 AMD21433.1 - 0.059 12.8 0.5 0.8 9.1 0.0 2.2 1 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic EMC3_TMCO1 PF01956.16 AMD21433.1 - 0.084 12.6 0.0 0.57 9.9 0.0 2.0 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Fusion_gly PF00523.18 AMD21433.1 - 0.093 11.0 4.6 0.031 12.5 0.7 2.0 2 1 0 2 2 2 0 Fusion glycoprotein F0 Cupin_4 PF08007.12 AMD21433.1 - 0.21 11.0 5.5 0.11 12.0 3.2 1.7 1 1 1 2 2 2 0 Cupin superfamily protein HIP1_clath_bdg PF16515.5 AMD21433.1 - 0.33 11.6 11.0 0.57 10.8 2.7 2.5 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cir_Bir_Yir PF06022.11 AMD21433.1 - 0.35 10.3 3.5 0.99 8.8 3.5 2.0 1 1 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir Occludin_ELL PF07303.13 AMD21433.1 - 0.37 11.5 3.7 0.58 10.9 0.4 2.2 2 0 0 2 2 2 0 Occludin homology domain MRP-S26 PF14943.6 AMD21433.1 - 0.39 10.6 4.6 0.35 10.8 2.4 2.0 1 1 1 2 2 2 0 Mitochondrial ribosome subunit S26 Retrotrans_gag PF03732.17 AMD21433.1 - 0.45 10.8 6.2 0.85 9.9 0.5 2.9 2 1 0 3 3 3 0 Retrotransposon gag protein Enkurin PF13864.6 AMD21433.1 - 1.4 9.4 6.9 0.31 11.5 1.0 2.5 1 1 1 2 2 2 0 Calmodulin-binding FlaC_arch PF05377.11 AMD21433.1 - 2.1 8.8 5.3 4.8 7.6 0.4 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 AMD21433.1 - 2.1 8.9 12.0 6.2 7.4 3.8 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF745 PF05335.13 AMD21433.1 - 2.3 7.9 8.7 0.66 9.7 1.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Syntaxin-6_N PF09177.11 AMD21433.1 - 7.3 7.2 9.2 2.7e+02 2.2 0.7 3.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CCDC-167 PF15188.6 AMD21433.1 - 9 6.7 10.0 2.6 8.4 2.2 2.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Fer2 PF00111.27 AMD21434.1 - 7.6e-13 48.2 2.1 1e-12 47.8 2.1 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Microtub_bd PF16796.5 AMD21435.1 - 2.1e-20 73.2 0.9 2.1e-20 73.2 0.9 2.3 2 0 0 2 2 2 1 Microtubule binding Laminin_II PF06009.12 AMD21435.1 - 0.27 11.2 19.6 0.18 11.8 4.1 3.5 2 2 1 3 3 3 0 Laminin Domain II zf-C2H2_assoc2 PF16624.5 AMD21435.1 - 3.2 8.8 6.1 3 8.9 3.4 2.4 1 1 1 2 2 2 0 Unstructured region upstream of a zinc-finger SAGA-Tad1 PF12767.7 AMD21436.1 - 4.1e-72 242.7 0.4 6.8e-72 242.0 0.4 1.4 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 AMD21436.1 - 0.0018 18.1 0.7 0.0051 16.6 0.0 2.0 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family DUF4694 PF15765.5 AMD21436.1 - 0.076 13.0 1.8 0.18 11.8 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4694) BBP1_C PF15272.6 AMD21437.1 - 1.8e-30 106.3 33.5 3.5e-30 105.3 29.9 2.4 2 1 0 2 2 2 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.6 AMD21437.1 - 1.7e-19 71.1 0.7 1.7e-19 71.1 0.7 2.6 2 1 0 2 2 2 1 Spindle pole body component BBP1, Mps2-binding protein DUF4407 PF14362.6 AMD21437.1 - 2.3 7.5 6.9 4 6.7 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cyclin_N PF00134.23 AMD21439.1 - 5.6e-38 129.6 0.0 9.6e-38 128.8 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF1730 PF08331.10 AMD21439.1 - 0.021 14.7 0.5 2.2 8.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1730) Rot1 PF10681.9 AMD21440.1 - 1.3e-94 315.6 0.0 1.6e-94 315.3 0.0 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal VHS PF00790.19 AMD21441.1 - 3.3e-37 127.5 0.5 7.4e-37 126.3 0.5 1.6 1 0 0 1 1 1 1 VHS domain FYVE PF01363.21 AMD21441.1 - 1.8e-18 66.4 4.0 5.8e-18 64.8 4.0 1.9 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 AMD21441.1 - 0.0016 18.2 1.0 0.0016 18.2 1.0 4.0 5 0 0 5 5 5 2 Ubiquitin interaction motif GAT PF03127.14 AMD21441.1 - 0.046 14.0 0.4 0.046 14.0 0.4 2.4 2 0 0 2 2 2 0 GAT domain zf-AN1 PF01428.16 AMD21441.1 - 0.33 11.2 8.2 1 9.6 8.2 1.8 1 0 0 1 1 1 0 AN1-like Zinc finger XPA_C PF05181.12 AMD21442.1 - 3e-21 75.1 0.2 5.9e-21 74.2 0.2 1.5 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 AMD21442.1 - 0.27 11.3 3.7 0.44 10.6 0.4 2.5 2 0 0 2 2 2 0 XPA protein N-terminal Autophagy_N PF03986.13 AMD21443.1 - 2.5e-40 137.6 1.6 8.6e-40 135.9 0.1 2.0 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 AMD21443.1 - 1.1e-14 53.7 1.5 1.1e-14 53.7 1.5 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 AMD21443.1 - 2.6e-14 53.5 0.0 6.8e-14 52.2 0.0 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain DUF4711 PF15829.5 AMD21443.1 - 0.072 13.0 0.4 0.14 12.0 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) LCAT PF02450.15 AMD21444.1 - 4.6e-125 417.8 0.1 5.7e-125 417.5 0.1 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 AMD21444.1 - 0.051 14.2 0.0 0.13 12.9 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family ERG2_Sigma1R PF04622.12 AMD21445.1 - 3.5e-87 291.1 1.6 4.3e-87 290.8 1.6 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Med9 PF07544.13 AMD21446.1 - 1.6e-19 69.8 0.4 2.2e-19 69.3 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 TMPIT PF07851.13 AMD21446.1 - 0.097 11.9 0.2 0.11 11.7 0.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein Porin_3 PF01459.22 AMD21447.1 - 7.3e-90 301.1 0.5 8.6e-90 300.9 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic porin Inp1 PF12634.7 AMD21448.1 - 1.3e-20 73.8 0.1 2.3e-20 73.0 0.1 1.4 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 PFK PF00365.20 AMD21449.1 - 1.3e-181 602.2 2.5 3.9e-100 334.8 0.6 2.1 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.19 AMD21449.1 - 0.12 12.2 0.4 0.25 11.2 0.4 1.5 1 0 0 1 1 1 0 UvrB/uvrC motif AFP_2 PF18815.1 AMD21449.1 - 0.13 12.5 0.1 0.34 11.2 0.1 1.7 1 0 0 1 1 1 0 Bacterial antifreeze protein repeat Glyoxalase PF00903.25 AMD21450.1 - 3.7e-35 120.9 0.6 3.1e-18 66.2 0.1 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 AMD21450.1 - 2.3e-06 27.8 0.0 0.0012 19.0 0.0 2.8 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AMD21450.1 - 0.00045 21.0 0.0 0.63 10.9 0.0 2.8 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 AMD21450.1 - 0.00072 19.5 0.4 1.9 8.4 0.0 3.6 4 0 0 4 4 4 2 Glyoxalase-like domain CppA_N PF14506.6 AMD21450.1 - 0.00081 19.5 0.0 0.57 10.3 0.0 2.4 2 0 0 2 2 2 2 CppA N-terminal Glyoxalase_3 PF13468.6 AMD21450.1 - 0.016 15.4 0.0 0.046 13.8 0.0 1.8 1 1 1 2 2 2 0 Glyoxalase-like domain RRM_1 PF00076.22 AMD21450.1 - 0.053 13.3 0.1 15 5.5 0.0 3.0 2 1 1 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MBG PF17883.1 AMD21450.1 - 0.076 13.6 1.3 0.83 10.3 0.2 2.9 3 0 0 3 3 3 0 MBG domain OB_NTP_bind PF07717.16 AMD21451.1 - 1.2e-15 57.6 0.0 3.3e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 AMD21451.1 - 6.9e-15 55.3 0.0 2.2e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AMD21451.1 - 2.1e-14 53.8 0.0 7.6e-14 52.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD21451.1 - 2.5e-06 27.4 0.0 5.1e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AMD21451.1 - 0.00049 20.4 0.5 0.0033 17.7 0.2 2.5 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 AMD21451.1 - 0.00055 19.1 0.0 0.0013 17.9 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.15 AMD21451.1 - 0.0011 19.1 0.0 0.013 15.5 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 AMD21451.1 - 0.0014 19.0 0.1 0.0033 17.8 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AMD21451.1 - 0.0042 16.8 0.0 0.0092 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AMD21451.1 - 0.055 13.1 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 AMD21451.1 - 0.1 13.0 0.0 0.41 11.0 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 AMD21451.1 - 0.49 10.9 1.7 2.5 8.6 0.0 2.8 3 0 0 3 3 3 0 ABC transporter PRK PF00485.18 AMD21452.1 - 1.3e-65 220.8 0.0 2.1e-65 220.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 AMD21452.1 - 1.7e-36 125.6 0.1 2.8e-36 124.9 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 AMD21452.1 - 8.8e-06 26.3 0.0 1.9e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 AMD21452.1 - 0.00035 20.5 0.0 0.00072 19.4 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 AMD21452.1 - 0.0079 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 AMD21452.1 - 0.0085 16.5 0.5 0.47 10.9 0.5 2.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AMD21452.1 - 0.029 14.5 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 AMD21452.1 - 0.15 12.1 1.6 0.39 10.8 1.6 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SPX PF03105.19 AMD21453.1 - 1.6e-35 123.8 15.4 3.8e-22 79.7 6.6 2.8 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 AMD21453.1 - 2.6e-24 86.1 41.5 3.9e-24 85.5 41.5 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AMD21453.1 - 2.9e-21 76.0 46.4 4.3e-16 59.0 22.4 2.2 1 1 1 2 2 2 2 Citrate transporter DUF4667 PF15700.5 AMD21454.1 - 5.1e-11 43.1 0.2 5.1e-11 43.1 0.2 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4667) DUF1708 PF08101.11 AMD21455.1 - 1.8e-72 244.9 3.0 2.9e-72 244.2 3.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Dus PF01207.17 AMD21456.1 - 1.1e-48 166.0 0.0 2.8e-48 164.6 0.0 1.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) ANAPC_CDC26 PF10471.9 AMD21456.1 - 0.19 12.6 0.2 0.31 11.9 0.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 ACC_central PF08326.12 AMD21457.1 - 3.9e-263 875.1 0.0 5.4e-263 874.6 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 AMD21457.1 - 2.7e-184 613.4 0.0 3.5e-184 613.1 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 AMD21457.1 - 8.4e-52 175.7 0.0 1.7e-51 174.7 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 AMD21457.1 - 5e-30 104.3 0.1 1.4e-29 102.9 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AMD21457.1 - 1.1e-20 73.7 0.0 8.2e-20 70.9 0.0 2.5 3 0 0 3 3 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 AMD21457.1 - 1.1e-17 63.6 0.0 2.8e-17 62.3 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ABC_tran_CTD PF16326.5 AMD21457.1 - 0.00088 19.5 1.3 0.0034 17.6 1.3 2.0 1 0 0 1 1 1 1 ABC transporter C-terminal domain ATP-grasp_3 PF02655.14 AMD21457.1 - 0.001 19.2 0.0 0.0044 17.1 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 AMD21457.1 - 0.0012 18.5 0.0 0.0033 17.0 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus GxGYxYP_N PF16216.5 AMD21457.1 - 0.026 14.7 0.0 0.064 13.4 0.0 1.6 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal ATPgrasp_Ter PF15632.6 AMD21457.1 - 0.076 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon RnfC_N PF13375.6 AMD21457.1 - 0.09 12.7 0.0 0.29 11.1 0.0 1.9 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Dynein_C PF18199.1 AMD21457.1 - 0.1 11.8 0.1 0.21 10.8 0.1 1.5 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain Tim17 PF02466.19 AMD21458.1 - 1.2e-25 90.1 2.7 1.5e-25 89.7 2.7 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Peptidase_S8 PF00082.22 AMD21459.1 - 6.4e-32 111.0 1.3 4.2e-31 108.3 1.0 2.0 1 1 0 1 1 1 1 Subtilase family SDA1 PF05285.12 AMD21459.1 - 0.00058 19.4 19.0 0.00085 18.8 19.0 1.2 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 AMD21459.1 - 0.32 9.2 26.4 0.45 8.7 26.4 1.1 1 0 0 1 1 1 0 Nop14-like family HIG_1_N PF04588.13 AMD21460.1 - 9.7e-07 28.9 0.5 1.6e-06 28.2 0.5 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Ribosomal_L19 PF01245.20 AMD21461.1 - 1.8e-08 34.3 0.2 2.6e-08 33.8 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 MutS_IV PF05190.18 AMD21461.1 - 0.007 16.7 0.0 0.03 14.7 0.0 2.0 2 0 0 2 2 2 1 MutS family domain IV WBS_methylT PF12589.8 AMD21462.1 - 1.8e-13 51.0 6.6 3.6e-13 50.1 6.6 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 AMD21462.1 - 1.2e-12 48.3 0.0 2.7e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD21462.1 - 2.6e-10 40.9 0.0 6.7e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD21462.1 - 9.3e-07 29.5 0.0 3.3e-06 27.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AMD21462.1 - 1.3e-05 24.7 0.0 6.5e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 AMD21462.1 - 4.5e-05 23.3 0.0 7.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD21462.1 - 0.0005 19.9 0.0 0.0011 18.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AMD21462.1 - 0.002 17.9 0.0 0.0069 16.2 0.0 1.8 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AdoMet_MTase PF07757.13 AMD21462.1 - 0.006 16.9 0.1 0.015 15.6 0.0 1.7 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase PrmA PF06325.13 AMD21462.1 - 0.017 14.6 0.3 0.05 13.0 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 AMD21462.1 - 0.03 13.9 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Bin3 PF06859.12 AMD21462.1 - 0.09 13.4 0.1 0.33 11.6 0.0 2.0 2 1 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) MBOAT PF03062.19 AMD21463.1 - 9e-65 219.3 37.1 1.1e-64 219.0 37.1 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 AMD21463.1 - 0.0074 16.5 5.8 0.023 15.0 5.8 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Peptidase_M76 PF09768.9 AMD21464.1 - 2.6e-71 238.9 2.6 3.1e-71 238.6 2.6 1.1 1 0 0 1 1 1 1 Peptidase M76 family Chromo PF00385.24 AMD21464.1 - 0.019 14.8 0.8 0.066 13.1 0.1 2.4 3 0 0 3 3 3 0 Chromo (CHRromatin Organisation MOdifier) domain Tox-MPTase2 PF15638.6 AMD21464.1 - 0.042 13.6 0.1 0.07 12.9 0.1 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 2 DinI PF06183.13 AMD21464.1 - 0.05 13.9 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 DinI-like family DUF5613 PF18467.1 AMD21464.1 - 0.51 10.8 4.3 1.8 9.0 1.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5613) Ank_5 PF13857.6 AMD21465.1 - 8.6e-17 61.0 0.1 7.8e-12 45.2 0.2 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 AMD21465.1 - 3.2e-14 53.1 0.2 5.4e-08 33.2 0.2 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 AMD21465.1 - 5.9e-13 49.2 0.3 9.4e-12 45.4 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 AMD21465.1 - 9.6e-11 41.6 0.4 1.3e-06 28.6 0.4 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 AMD21465.1 - 5.6e-09 35.5 0.3 7e-06 26.0 0.2 3.8 3 1 0 3 3 3 1 Ankyrin repeat Herpes_UL35 PF04496.12 AMD21465.1 - 0.094 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL35 family DUF1682 PF07946.14 AMD21466.1 - 3.9e-67 226.8 7.0 4.7e-67 226.5 7.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Ribosomal_L9_N PF01281.19 AMD21467.1 - 0.013 15.0 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L9, N-terminal domain Polbeta PF18765.1 AMD21467.1 - 0.038 14.1 0.2 0.093 12.8 0.1 1.6 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase LapD_MoxY_N PF16448.5 AMD21467.1 - 0.12 12.3 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 LapD/MoxY periplasmic domain SWIB PF02201.18 AMD21468.1 - 4.5e-05 23.2 0.5 0.00029 20.7 0.5 2.2 1 1 0 1 1 1 1 SWIB/MDM2 domain Thr_synth_N PF14821.6 AMD21469.1 - 1.8e-28 98.6 0.0 7.3e-28 96.6 0.0 2.1 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 AMD21469.1 - 5.7e-11 42.4 0.0 1.1e-10 41.4 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Atx10homo_assoc PF09759.9 AMD21470.1 - 4.1e-36 123.0 0.5 9.3e-36 121.8 0.5 1.6 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain DUF4105 PF13387.6 AMD21470.1 - 0.00038 20.1 0.0 0.0006 19.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4105) WD40 PF00400.32 AMD21471.1 - 5.9e-45 150.3 13.7 1.6e-09 38.2 0.1 12.4 14 0 0 14 14 14 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21471.1 - 2.4e-30 104.7 1.3 0.0084 16.4 0.0 10.5 7 2 5 12 12 12 9 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 AMD21471.1 - 1.5e-26 92.8 0.0 2.7e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.11 AMD21471.1 - 1.5e-07 31.5 5.6 0.048 13.5 0.1 5.8 4 1 2 6 6 6 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AMD21471.1 - 1.7e-07 30.5 2.9 0.027 13.4 0.0 6.1 3 3 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 AMD21471.1 - 0.0002 20.8 1.2 2.2 7.5 0.0 4.7 4 1 1 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 AMD21471.1 - 0.00087 17.9 0.7 0.027 13.0 0.0 3.4 4 1 0 4 4 4 1 Cytochrome D1 heme domain WD40_3 PF15911.5 AMD21471.1 - 0.0016 18.4 0.0 0.009 16.0 0.0 2.3 1 0 0 1 1 1 1 WD domain, G-beta repeat Nup160 PF11715.8 AMD21471.1 - 0.0029 16.4 5.5 1.8 7.1 0.0 5.1 4 2 3 7 7 7 1 Nucleoporin Nup120/160 PD40 PF07676.12 AMD21471.1 - 0.14 12.1 0.1 40 4.3 0.0 3.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat NUC153 PF08159.12 AMD21472.1 - 2e-10 40.3 4.4 4.3e-10 39.2 4.4 1.6 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 AMD21472.1 - 0.019 15.8 1.8 11 7.1 0.0 4.1 4 0 0 4 4 4 0 WD domain, G-beta repeat Ecl1 PF12855.7 AMD21474.1 - 1e-10 43.0 0.2 1.1e-10 42.9 0.2 1.1 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins Prok-RING_1 PF14446.6 AMD21474.1 - 0.042 13.8 1.1 0.072 13.0 1.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-MYND PF01753.18 AMD21474.1 - 0.056 13.5 1.0 0.12 12.5 1.0 1.5 1 0 0 1 1 1 0 MYND finger zf-FLZ PF04570.14 AMD21474.1 - 0.25 10.9 4.3 1.4 8.4 4.3 2.1 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF2116 PF09889.9 AMD21474.1 - 0.33 11.0 1.5 0.64 10.0 1.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF2256 PF10013.9 AMD21474.1 - 0.38 10.9 3.0 1.1 9.4 1.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2 PF00096.26 AMD21475.1 - 3.4e-09 36.6 11.0 0.00027 21.2 0.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD21475.1 - 2.7e-07 30.7 12.3 6.7e-05 23.1 2.4 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD21475.1 - 4.4e-05 24.0 9.5 0.053 14.4 2.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AMD21475.1 - 0.011 15.7 1.9 3 7.9 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 AMD21475.1 - 0.12 12.3 4.7 5.6 7.0 0.4 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 AMD21475.1 - 0.12 12.7 1.1 0.57 10.5 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF1279 PF06916.13 AMD21478.1 - 2.4e-24 85.7 0.0 3.3e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) VF530 PF09905.9 AMD21478.1 - 0.12 12.6 0.1 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 DNA-binding protein VF530 AGA2 PF17366.2 AMD21479.1 - 1.3e-11 44.0 2.7 1.3e-11 44.0 2.7 3.3 3 1 0 3 3 3 1 A-agglutinin-binding subunit Aga2 Ribosomal_L24e PF01246.20 AMD21480.1 - 2.2e-29 101.5 0.1 2.2e-29 101.5 0.1 2.0 2 1 0 2 2 2 1 Ribosomal protein L24e UNC-79 PF14776.6 AMD21480.1 - 0.34 9.6 1.0 0.4 9.4 1.0 1.0 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Ribosomal_L7Ae PF01248.26 AMD21481.1 - 1.2e-23 82.7 0.0 1.3e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF2838 PF10998.8 AMD21482.1 - 9.3e-40 135.3 16.0 9.3e-40 135.3 16.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) PPR_2 PF13041.6 AMD21483.1 - 3.1e-19 68.9 9.3 3.9e-14 52.6 0.2 4.4 4 0 0 4 4 4 2 PPR repeat family PPR_1 PF12854.7 AMD21483.1 - 1.1e-13 50.7 0.2 3.6e-08 33.0 0.1 3.6 3 0 0 3 3 3 2 PPR repeat PPR PF01535.20 AMD21483.1 - 3e-09 36.5 10.7 1.5e-06 28.0 0.0 4.6 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 AMD21483.1 - 1.9e-08 34.2 1.4 0.00014 21.9 0.2 4.4 4 1 1 5 5 5 2 Pentatricopeptide repeat domain PPR_long PF17177.4 AMD21483.1 - 1.8e-06 27.5 0.1 1.8e-06 27.5 0.1 3.4 3 1 1 4 4 4 1 Pentacotripeptide-repeat region of PRORP Cgr1 PF03879.14 AMD21484.1 - 2.6e-34 117.8 29.9 2.6e-34 117.8 29.9 1.4 1 1 1 2 2 2 1 Cgr1 family FapA PF03961.13 AMD21484.1 - 3.5 6.1 10.3 3.2 6.3 10.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Atg14 PF10186.9 AMD21484.1 - 8.5 5.4 13.2 9 5.3 13.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MIOX PF05153.15 AMD21485.1 - 3.2e-118 393.8 6.0 4e-118 393.5 6.0 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 AMD21485.1 - 0.0022 18.2 0.5 0.36 11.0 0.4 2.6 1 1 0 1 1 1 1 HD domain UBD PF16455.5 AMD21485.1 - 0.073 13.3 0.1 0.26 11.5 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-binding domain HH_signal PF01085.18 AMD21485.1 - 0.091 12.4 0.2 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 Hedgehog amino-terminal signalling domain Glyco_hydro_63 PF03200.16 AMD21486.1 - 3.3e-162 540.7 0.5 2.4e-161 537.8 0.5 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 AMD21486.1 - 7.2e-58 196.4 0.1 1.3e-57 195.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain MHCassoc_trimer PF08831.10 AMD21486.1 - 0.022 14.7 0.1 0.32 11.0 0.0 2.9 3 0 0 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain Rrn6 PF10214.9 AMD21487.1 - 5e-101 339.6 30.9 1.2e-79 268.9 5.2 2.8 2 1 0 2 2 2 2 RNA polymerase I-specific transcription-initiation factor Trp_syntA PF00290.20 AMD21488.1 - 3.7e-91 304.6 0.1 6.1e-91 303.8 0.1 1.3 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 AMD21488.1 - 1.7e-48 165.6 1.7 2.8e-48 164.8 1.7 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PcrB PF01884.17 AMD21488.1 - 0.1 12.0 0.1 0.22 10.9 0.1 1.5 1 0 0 1 1 1 0 PcrB family Med3 PF11593.8 AMD21489.1 - 4.1e-32 111.9 15.4 3.6e-29 102.2 0.2 3.0 2 1 1 3 3 3 3 Mediator complex subunit 3 fungal PriCT_2 PF08707.11 AMD21490.1 - 0.065 13.6 0.1 0.77 10.2 0.1 2.5 1 1 0 1 1 1 0 Primase C terminal 2 (PriCT-2) Utp14 PF04615.13 AMD21491.1 - 4.8e-199 663.6 74.6 4.8e-199 663.6 74.6 2.1 1 1 1 2 2 2 1 Utp14 protein TcdB_toxin_midC PF12255.8 AMD21491.1 - 0.16 12.1 7.5 0.028 14.5 2.0 2.6 2 1 0 2 2 2 0 Insecticide toxin TcdB middle/C-terminal region InvH PF04741.12 AMD21491.1 - 2.4 8.1 7.3 7.6 6.5 7.3 1.8 1 0 0 1 1 1 0 InvH outer membrane lipoprotein Proteasome PF00227.26 AMD21492.1 - 6.6e-59 198.6 0.0 8.5e-59 198.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AMD21492.1 - 2.3e-09 36.8 0.7 5e-09 35.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature zf_CCCH_4 PF18345.1 AMD21493.1 - 2.6e-08 33.7 6.1 1.5e-05 24.9 1.1 2.6 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 AMD21493.1 - 9.4e-08 31.8 7.1 1.9e-05 24.4 2.3 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 AMD21493.1 - 0.00012 21.7 0.6 0.00012 21.7 0.6 3.1 4 0 0 4 4 4 2 CCCH-type zinc finger Torus PF16131.5 AMD21493.1 - 0.00029 21.5 4.0 0.013 16.2 0.1 2.9 2 1 1 3 3 3 1 Torus domain RRM_1 PF00076.22 AMD21493.1 - 0.00096 18.9 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 3H PF02829.14 AMD21493.1 - 0.055 13.8 0.1 0.13 12.6 0.0 1.6 1 1 0 1 1 1 0 3H domain zf-CCCH_3 PF15663.5 AMD21493.1 - 0.08 13.2 5.1 1.8 8.8 1.2 2.6 2 1 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 AMD21493.1 - 0.096 13.2 7.4 0.26 11.8 0.9 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Rtf2 PF04641.12 AMD21494.1 - 1.2e-35 123.1 0.1 6.4e-35 120.8 0.1 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger COX14 PF14880.6 AMD21495.1 - 4.2e-22 77.7 0.8 4.6e-22 77.6 0.8 1.0 1 0 0 1 1 1 1 Cytochrome oxidase c assembly Bac_rhamnosid_N PF08531.10 AMD21495.1 - 0.053 13.3 0.1 0.062 13.1 0.1 1.1 1 0 0 1 1 1 0 Alpha-L-rhamnosidase N-terminal domain Ish1 PF10281.9 AMD21496.1 - 5.3e-35 119.4 37.4 9.4e-11 41.8 0.2 6.3 6 0 0 6 6 5 5 Putative stress-responsive nuclear envelope protein HeH PF12949.7 AMD21496.1 - 2.6e-08 33.4 3.8 0.0027 17.4 0.5 5.0 5 0 0 5 5 5 1 HeH/LEM domain DUF883 PF05957.13 AMD21496.1 - 2.5e-06 28.0 5.8 0.27 11.9 1.6 4.8 2 1 4 6 6 6 4 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 AMD21496.1 - 0.011 15.6 0.0 6.9 6.5 0.0 3.3 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain DUF4230 PF14014.6 AMD21496.1 - 0.014 15.7 0.0 0.065 13.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) Slx4 PF09494.10 AMD21496.1 - 0.078 12.9 0.5 30 4.7 0.0 3.7 4 1 0 4 4 4 0 Slx4 endonuclease DUF4518 PF15008.6 AMD21496.1 - 0.12 11.5 1.7 26 3.9 0.1 3.4 3 1 1 4 4 3 0 Domain of unknown function (DUF4518) Herpes_ori_bp PF02399.15 AMD21496.1 - 0.15 10.1 0.0 0.24 9.4 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein V-ATPase_G_2 PF16999.5 AMD21496.1 - 0.4 11.1 2.3 15 6.0 0.0 2.7 1 1 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit YtxH PF12732.7 AMD21496.1 - 1.2 9.7 31.9 4.9 7.7 0.1 6.5 5 2 1 6 6 5 0 YtxH-like protein SAM_2 PF07647.17 AMD21496.1 - 1.6 8.9 3.5 42 4.4 0.0 4.2 5 0 0 5 5 5 0 SAM domain (Sterile alpha motif) RPM2 PF08579.11 AMD21498.1 - 1.7e-40 138.1 1.1 8.6e-40 135.9 0.2 2.8 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.6 AMD21498.1 - 8.7e-05 22.6 4.1 0.016 15.4 0.0 5.8 7 0 0 7 7 7 1 PPR repeat family HMG_CoA_synt_C PF08540.10 AMD21499.1 - 6.3e-111 370.5 1.4 7.8e-111 370.2 1.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 AMD21499.1 - 2e-96 320.8 0.1 3.5e-96 320.1 0.1 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Mus7 PF09462.10 AMD21500.1 - 1.4e-30 106.7 26.1 2e-20 73.2 7.3 2.8 2 1 1 3 3 3 2 Mus7/MMS22 family DUF1041 PF06292.17 AMD21500.1 - 0.007 16.7 0.3 0.078 13.4 0.1 2.9 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1041) YgaB PF14182.6 AMD21500.1 - 0.02 15.2 0.3 0.11 12.9 0.3 2.3 1 0 0 1 1 1 0 YgaB-like protein Fungal_TACC PF12709.7 AMD21500.1 - 0.083 13.3 10.3 0.13 12.8 1.2 4.5 4 0 0 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins DNA_III_psi PF03603.13 AMD21500.1 - 0.15 12.3 1.1 0.54 10.5 0.2 2.5 2 0 0 2 2 2 0 DNA polymerase III psi subunit AIP3 PF03915.13 AMD21501.1 - 1.7e-133 445.7 15.6 1.7e-133 445.7 15.6 2.2 2 0 0 2 2 2 1 Actin interacting protein 3 RE_MjaI PF09568.10 AMD21501.1 - 0.0013 18.5 0.1 0.0042 16.9 0.1 1.9 1 0 0 1 1 1 1 MjaI restriction endonuclease FUSC PF04632.12 AMD21501.1 - 0.33 9.5 1.4 1 7.8 0.0 1.9 2 0 0 2 2 2 0 Fusaric acid resistance protein family Telomerase_RBD PF12009.8 AMD21502.1 - 5.4e-28 97.8 0.2 1.9e-27 96.0 0.2 2.0 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 AMD21502.1 - 3.8e-10 39.7 1.2 1.3e-06 28.1 0.1 3.1 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) dCMP_cyt_deam_1 PF00383.23 AMD21503.1 - 2.7e-07 30.4 0.2 4.4e-07 29.7 0.2 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AMD21503.1 - 6.6e-05 22.7 0.1 0.00013 21.7 0.1 1.5 1 0 0 1 1 1 1 MafB19-like deaminase Haspin_kinase PF12330.8 AMD21504.1 - 2.1e-82 277.0 3.8 2.1e-82 277.0 3.8 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase PF00069.25 AMD21504.1 - 1.3e-05 24.7 0.0 2.9e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21504.1 - 0.00016 21.0 0.0 0.00044 19.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase STT3 PF02516.14 AMD21505.1 - 1.6e-149 499.0 40.7 2.3e-146 488.5 39.7 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit FYVE PF01363.21 AMD21506.1 - 1e-14 54.4 5.8 2.5e-14 53.2 5.8 1.7 1 0 0 1 1 1 1 FYVE zinc finger Acyltransferase PF01553.21 AMD21507.1 - 1.1e-09 38.0 0.0 6.8e-09 35.5 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase FA_desaturase PF00487.24 AMD21507.1 - 3 7.6 4.4 1.5 8.6 1.7 1.7 2 0 0 2 2 2 0 Fatty acid desaturase Formyl_trans_N PF00551.19 AMD21508.1 - 2.7e-26 92.4 0.0 3.8e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 AMD21508.1 - 1.5e-05 25.1 0.0 3.2e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Prefoldin PF02996.17 AMD21509.1 - 2.2e-28 98.6 1.8 3.2e-28 98.0 1.8 1.3 1 0 0 1 1 1 1 Prefoldin subunit GIT_CC PF16559.5 AMD21509.1 - 0.014 15.3 7.0 1.2 9.1 5.6 2.4 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PHM7_cyt PF14703.6 AMD21509.1 - 0.039 14.2 5.5 0.083 13.1 4.9 1.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Methyltransf_25 PF13649.6 AMD21509.1 - 0.073 13.8 0.6 4.4 8.1 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain betaPIX_CC PF16523.5 AMD21509.1 - 0.19 11.6 5.3 0.51 10.2 0.4 2.3 2 1 0 2 2 2 0 betaPIX coiled coil DUF1043 PF06295.12 AMD21509.1 - 0.39 10.7 7.4 0.4 10.7 2.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Sec20 PF03908.13 AMD21509.1 - 0.66 9.9 4.3 1.9 8.5 0.6 2.4 2 0 0 2 2 2 0 Sec20 Fib_alpha PF08702.10 AMD21509.1 - 1.3 9.2 7.6 54 4.0 7.6 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Plk4_PB2 PF18409.1 AMD21509.1 - 2.8 8.7 6.1 3.7 8.3 0.8 2.1 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 TMPIT PF07851.13 AMD21509.1 - 8.8 5.5 9.8 8.3 5.6 2.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein Rad10 PF03834.14 AMD21510.1 - 2.6e-37 127.3 0.1 3.8e-37 126.8 0.1 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Asn_synthase PF00733.21 AMD21511.1 - 3.3e-21 76.3 0.1 4.9e-12 46.2 0.0 2.8 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AMD21511.1 - 1e-10 41.6 0.1 4.9e-09 36.2 0.1 2.6 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AMD21511.1 - 1.3e-05 25.4 0.0 5.2e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 AMD21511.1 - 0.012 15.1 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Aluminium induced protein NdhS PF11623.8 AMD21511.1 - 0.03 14.0 0.0 0.081 12.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S VPS9 PF02204.18 AMD21512.1 - 2e-28 98.6 0.1 4.5e-28 97.5 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 AMD21512.1 - 9e-12 45.1 0.1 3.6e-11 43.2 0.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 AMD21512.1 - 2.2e-11 43.2 0.0 6.4e-10 38.6 0.0 2.8 2 0 0 2 2 2 1 CUE domain ICEA PF05315.11 AMD21512.1 - 0.068 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 ICEA Protein ERO1 PF04137.15 AMD21513.1 - 3.6e-120 401.4 0.1 3.6e-120 401.4 0.1 1.5 2 0 0 2 2 2 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) TFIID-18kDa PF02269.16 AMD21514.1 - 3.5e-31 107.1 0.0 5.2e-31 106.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TAF PF02969.17 AMD21514.1 - 0.0047 17.1 0.3 0.033 14.4 0.0 2.1 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 AMD21514.1 - 0.01 16.2 3.4 0.09 13.1 0.0 2.9 3 1 1 4 4 4 1 Core histone H2A/H2B/H3/H4 Fungal_trans_2 PF11951.8 AMD21515.1 - 2.6e-76 256.9 5.0 4.3e-76 256.2 5.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD21515.1 - 1.1e-11 44.6 7.6 2.7e-11 43.4 7.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vac14_Fig4_bd PF11916.8 AMD21515.1 - 0.0045 16.7 2.2 0.0082 15.8 2.2 1.5 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Pep1_7 PF17232.2 AMD21515.1 - 0.1 13.1 0.1 0.42 11.1 0.1 2.1 1 0 0 1 1 1 0 Elicitor peptide 1-7 6PF2K PF01591.18 AMD21516.1 - 1.2e-79 266.7 1.6 5.8e-79 264.5 0.1 2.1 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AMD21516.1 - 1.1e-31 110.1 0.0 3.5e-30 105.2 0.0 2.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AMD21516.1 - 1.1e-05 25.6 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD21516.1 - 0.0027 18.3 0.0 0.0027 18.3 0.0 2.2 3 0 0 3 3 3 1 AAA domain KTI12 PF08433.10 AMD21516.1 - 0.019 14.4 0.0 0.049 13.1 0.0 1.7 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_17 PF13207.6 AMD21516.1 - 0.02 15.3 0.0 0.05 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 AMD21516.1 - 0.038 13.3 0.0 0.074 12.3 0.0 1.5 1 1 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 AMD21516.1 - 0.083 13.0 0.0 0.6 10.2 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase APS_kinase PF01583.20 AMD21516.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Pox_A28 PF04584.14 AMD21516.1 - 0.2 11.8 0.8 0.65 10.2 0.0 2.1 2 0 0 2 2 2 0 Poxvirus A28 family Metallopep PF12044.8 AMD21517.1 - 2.2e-166 553.7 0.0 3.8e-166 552.9 0.0 1.4 2 0 0 2 2 2 1 Putative peptidase family Jacalin PF01419.17 AMD21517.1 - 9.4e-06 25.6 0.2 0.029 14.3 0.0 2.5 1 1 1 2 2 2 2 Jacalin-like lectin domain Reprolysin_5 PF13688.6 AMD21517.1 - 0.0095 16.1 0.1 0.016 15.4 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 AMD21517.1 - 0.039 14.5 0.1 0.084 13.4 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 AMD21517.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Matrixin Sec23_trunk PF04811.15 AMD21518.1 - 1.4e-70 237.6 0.0 3.9e-70 236.2 0.0 1.7 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 AMD21518.1 - 3.4e-21 75.0 0.0 7.9e-21 73.8 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AMD21518.1 - 3.7e-18 65.3 3.9 7e-18 64.4 3.9 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 AMD21518.1 - 1e-16 61.4 2.8 2.2e-16 60.3 0.1 2.9 4 0 0 4 4 4 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 AMD21518.1 - 3.8e-10 39.5 0.0 8.9e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 AMD21518.1 - 0.088 12.2 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF2011 PF09428.10 AMD21519.1 - 1.8e-15 56.9 0.0 3.5e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) COG5 PF10392.9 AMD21520.1 - 1.7e-37 128.6 3.3 1.7e-37 128.6 3.3 3.1 4 0 0 4 4 4 1 Golgi transport complex subunit 5 DUF733 PF05306.11 AMD21520.1 - 9.6 6.6 8.1 1.2 9.5 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF733) Methyltransf_16 PF10294.9 AMD21521.1 - 0.02 14.7 1.2 4.7 6.9 0.1 2.3 1 1 1 2 2 2 0 Lysine methyltransferase COX4 PF02936.14 AMD21522.1 - 6.7e-32 110.4 0.2 7.8e-32 110.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Ank_2 PF12796.7 AMD21523.1 - 2.4e-39 133.8 0.9 1e-17 64.5 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AMD21523.1 - 1.5e-27 95.3 0.2 1.3e-08 34.9 0.2 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD21523.1 - 3.9e-26 88.2 0.0 1.1e-07 31.6 0.2 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 AMD21523.1 - 6.6e-25 87.2 0.1 1.7e-10 41.2 0.0 5.0 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 AMD21523.1 - 8.9e-25 86.0 0.8 1.1e-07 31.9 0.3 5.7 5 0 0 5 5 5 4 Ankyrin repeat DSPc PF00782.20 AMD21524.1 - 2.3e-35 121.3 0.2 5.4e-35 120.1 0.2 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AMD21524.1 - 0.00041 20.0 0.0 0.00077 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 AMD21524.1 - 0.038 13.7 0.1 0.087 12.5 0.1 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Vac7 PF12751.7 AMD21525.1 - 1.4e-27 97.1 19.6 2.4e-18 66.8 12.4 4.2 3 1 1 4 4 4 2 Vacuolar segregation subunit 7 Porin_3 PF01459.22 AMD21526.1 - 2e-73 247.2 0.3 2.3e-73 247.0 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin NUP214 PF16755.5 AMD21527.1 - 6.3e-76 255.9 0.3 6.3e-76 255.9 0.3 1.8 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Aminotran_1_2 PF00155.21 AMD21528.1 - 7.1e-62 209.7 0.0 8.7e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 AMD21528.1 - 0.07 12.0 0.0 0.094 11.6 0.0 1.2 1 0 0 1 1 1 0 Allinase Cys_Met_Meta_PP PF01053.20 AMD21528.1 - 0.071 11.6 0.0 0.14 10.7 0.0 1.5 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Y_phosphatase2 PF03162.13 AMD21529.1 - 1e-53 181.3 0.0 1.2e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AMD21529.1 - 1.2e-05 25.4 0.0 1.5e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AMD21529.1 - 0.064 13.1 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PMP1_2 PF08114.11 AMD21530.1 - 0.086 12.6 0.2 0.2 11.4 0.2 1.5 1 0 0 1 1 1 0 ATPase proteolipid family Ras PF00071.22 AMD21531.1 - 6.7e-56 188.3 0.0 8.4e-56 188.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD21531.1 - 1.6e-22 80.0 0.0 2.4e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD21531.1 - 3e-09 36.6 0.0 6.7e-09 35.4 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 AMD21531.1 - 0.001 18.5 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 AMD21531.1 - 0.0051 16.9 0.0 0.0087 16.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AMD21531.1 - 0.0063 15.9 0.0 0.0076 15.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 AMD21531.1 - 0.0065 15.7 0.0 0.0071 15.6 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 AMD21531.1 - 0.059 13.9 0.0 0.1 13.1 0.0 1.5 2 0 0 2 2 2 0 ABC transporter Actin PF00022.19 AMD21532.1 - 4.2e-49 167.2 0.0 2.7e-29 102.0 0.0 2.3 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 AMD21532.1 - 0.017 14.0 0.0 0.2 10.5 0.0 2.4 3 0 0 3 3 3 0 MreB/Mbl protein Caldesmon PF02029.15 AMD21532.1 - 0.24 10.1 38.4 0.39 9.4 38.4 1.3 1 0 0 1 1 1 0 Caldesmon Methyltr_RsmB-F PF01189.17 AMD21533.1 - 1.2e-82 276.4 0.0 2.1e-82 275.6 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 AMD21533.1 - 4.8e-09 36.6 0.0 2.2e-08 34.5 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 AMD21533.1 - 0.025 14.7 0.0 0.063 13.4 0.0 1.7 1 0 0 1 1 1 0 FtsJ-like methyltransferase Bradykinin PF06753.12 AMD21533.1 - 0.27 11.0 0.8 0.63 9.8 0.8 1.6 1 0 0 1 1 1 0 Bradykinin Gcd10p PF04189.13 AMD21534.1 - 2.9e-96 322.1 0.1 3.6e-96 321.8 0.1 1.1 1 0 0 1 1 1 1 Gcd10p family CNP_C_terminal PF17839.1 AMD21534.1 - 1.5 9.5 5.2 0.34 11.7 0.4 2.4 2 2 0 2 2 2 0 C-terminal domain of cyclic nucleotide phosphodiesterase MTS PF05175.14 AMD21535.1 - 1.9e-11 43.8 0.0 3.2e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 AMD21535.1 - 9.6e-09 35.2 0.0 1.3e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD21535.1 - 8.6e-08 32.8 0.0 1.5e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD21535.1 - 0.00034 21.2 0.0 0.0007 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD21535.1 - 0.00045 20.1 0.0 0.00074 19.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AMD21535.1 - 0.0011 18.7 0.0 0.0017 18.0 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 AMD21535.1 - 0.0011 18.7 0.0 0.078 12.6 0.0 2.7 3 0 0 3 3 3 1 Putative RNA methylase family UPF0020 Methyltransf_10 PF05971.12 AMD21535.1 - 0.0017 17.7 0.0 0.0024 17.3 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase PrmA PF06325.13 AMD21535.1 - 0.0043 16.5 0.0 0.0062 16.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 AMD21535.1 - 0.011 16.5 0.0 0.02 15.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DnaJ_C PF01556.18 AMD21536.1 - 1.5e-39 135.4 0.2 1.9e-39 135.1 0.2 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AMD21536.1 - 4.6e-26 90.7 2.5 7.4e-26 90.1 2.5 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AMD21536.1 - 4e-15 55.9 16.3 4e-15 55.9 16.3 1.6 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.19 AMD21536.1 - 0.69 10.0 8.9 4.2 7.4 1.7 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 AMD21536.1 - 1 9.4 14.4 0.32 11.0 2.6 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein FidL_like PF15941.5 AMD21537.1 - 0.025 15.0 0.5 0.04 14.4 0.5 1.2 1 0 0 1 1 1 0 FidL-like putative membrane protein Y_phosphatase2 PF03162.13 AMD21538.1 - 9.3e-56 187.9 0.0 1.1e-55 187.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AMD21538.1 - 7.5e-06 26.1 0.0 3e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AMD21538.1 - 0.096 12.5 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DAD PF02109.16 AMD21539.1 - 6.9e-37 126.1 2.7 8.3e-37 125.8 2.7 1.1 1 0 0 1 1 1 1 DAD family Ras PF00071.22 AMD21540.1 - 8.5e-55 184.8 0.1 1.1e-54 184.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD21540.1 - 2.9e-19 69.5 0.0 4.4e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD21540.1 - 1.9e-09 37.2 0.0 2.3e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AMD21540.1 - 0.00015 21.4 0.1 0.00061 19.4 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AMD21540.1 - 0.002 18.2 0.0 0.0035 17.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD21540.1 - 0.0029 17.5 0.0 1.3 8.9 0.0 2.4 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 AMD21540.1 - 0.075 13.0 0.0 0.24 11.4 0.0 1.8 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain ParA PF10609.9 AMD21540.1 - 0.2 11.1 0.1 0.3 10.5 0.1 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase ING PF12998.7 AMD21541.1 - 1.1e-18 67.7 0.4 1.1e-18 67.7 0.4 2.0 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 AMD21541.1 - 0.00011 22.0 8.1 0.00021 21.1 8.1 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 AMD21541.1 - 0.0042 17.3 0.8 0.011 16.0 0.8 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain FAM92 PF06730.11 AMD21541.1 - 0.052 13.0 0.8 0.077 12.4 0.8 1.1 1 0 0 1 1 1 0 FAM92 protein PHD_2 PF13831.6 AMD21541.1 - 0.11 12.0 1.7 0.25 10.9 1.7 1.6 1 0 0 1 1 1 0 PHD-finger Mito_carr PF00153.27 AMD21542.1 - 4.7e-51 170.7 7.6 3.5e-18 65.3 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_15 PF01793.16 AMD21543.1 - 3e-126 421.1 11.7 3.7e-126 420.8 11.7 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_S7e PF01251.18 AMD21545.1 - 3.1e-80 268.3 3.3 3.6e-80 268.1 3.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Rib_5-P_isom_A PF06026.14 AMD21546.1 - 2.1e-57 193.5 0.0 2.7e-57 193.2 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 AMD21546.1 - 0.00012 22.1 0.0 0.0081 16.1 0.0 2.2 1 1 0 1 1 1 1 DeoR C terminal sensor domain Sugar-bind PF04198.13 AMD21546.1 - 0.1 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain Arf PF00025.21 AMD21547.1 - 4.7e-71 237.8 0.1 5.3e-71 237.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 AMD21547.1 - 9.4e-16 58.1 0.0 1.3e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AMD21547.1 - 2.4e-13 50.0 0.0 2.8e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 AMD21547.1 - 4.3e-13 49.2 0.8 1.8e-08 34.0 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 AMD21547.1 - 1.1e-12 47.7 0.0 1.4e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AMD21547.1 - 1.2e-10 41.1 0.0 1.5e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AMD21547.1 - 5.2e-06 26.5 0.0 7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AMP-binding PF00501.28 AMD21548.1 - 4.6e-36 124.3 0.0 1.5e-11 43.6 0.0 5.1 5 0 0 5 5 5 5 AMP-binding enzyme DMAP_binding PF06464.11 AMD21548.1 - 1.9e-05 25.4 0.2 4.6e-05 24.2 0.2 1.7 1 0 0 1 1 1 1 DMAP1-binding Domain Mem_trans PF03547.18 AMD21549.1 - 6.4e-32 110.4 0.0 2.9e-31 108.2 0.0 1.8 1 1 0 1 1 1 1 Membrane transport protein PEP-CTERM PF07589.11 AMD21549.1 - 2.1 8.6 3.8 2.3 8.4 1.8 2.2 2 0 0 2 2 2 0 PEP-CTERM motif DUF2183 PF09949.9 AMD21550.1 - 2.4e-30 104.8 0.1 1.2e-29 102.5 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 AMD21550.1 - 0.00043 19.8 0.1 0.0023 17.4 0.1 2.1 2 0 0 2 2 2 1 LNS2 (Lipin/Ned1/Smp2) DFRP_C PF16543.5 AMD21551.1 - 2.7e-23 82.3 10.2 2.7e-23 82.3 10.2 3.7 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 AMD21551.1 - 6.3e-06 26.0 0.3 6.3e-06 26.0 0.3 2.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AMD21551.1 - 0.00012 22.0 3.6 0.00012 22.0 3.6 3.1 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 AMD21551.1 - 0.0002 21.0 7.3 0.017 14.9 0.8 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 AMD21551.1 - 0.00024 21.7 12.8 0.002 18.8 1.7 3.6 2 1 1 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 AMD21551.1 - 0.31 11.6 12.2 0.84 10.2 1.8 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 AMD21551.1 - 0.37 11.0 6.2 1.1 9.5 0.2 3.1 2 1 1 3 3 3 0 Zinc-finger containing family SPOUT_MTase PF02590.17 AMD21551.1 - 0.49 10.4 5.4 11 6.0 0.7 3.1 3 0 0 3 3 3 0 Predicted SPOUT methyltransferase PP2C PF00481.21 AMD21552.1 - 3e-38 131.9 0.0 5e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Ras PF00071.22 AMD21553.1 - 2.2e-59 199.7 0.0 2.5e-59 199.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD21553.1 - 2.6e-35 121.3 0.0 3.4e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD21553.1 - 3.5e-17 62.4 0.0 3.8e-17 62.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD21553.1 - 2.1e-06 27.3 0.0 2.7e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AMD21553.1 - 3.3e-05 23.9 0.0 4.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD21553.1 - 0.0002 21.3 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 AMD21553.1 - 0.0003 20.4 0.0 0.0004 20.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain N2227 PF07942.12 AMD21554.1 - 5.7e-95 317.6 0.1 7.2e-95 317.3 0.1 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 AMD21554.1 - 0.002 18.7 0.0 0.015 16.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD21554.1 - 0.0046 17.7 0.0 0.012 16.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD21554.1 - 0.011 15.6 0.0 0.076 12.9 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain SLC12 PF03522.15 AMD21554.1 - 0.021 13.9 0.0 0.033 13.2 0.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Methyltransf_8 PF05148.15 AMD21554.1 - 0.05 13.5 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase NST1 PF13945.6 AMD21555.1 - 2.9e-12 47.1 8.4 2.9e-12 47.1 8.4 5.3 3 2 1 5 5 5 1 Salt tolerance down-regulator Ras PF00071.22 AMD21556.1 - 5e-50 169.3 0.0 5.9e-50 169.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD21556.1 - 5.2e-23 81.5 0.0 7.1e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD21556.1 - 2.1e-09 37.1 0.0 2.8e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 AMD21556.1 - 0.00018 21.2 0.0 0.18 11.5 0.0 2.3 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 AMD21556.1 - 0.03 13.8 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AMD21556.1 - 0.14 11.5 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region G-alpha PF00503.20 AMD21556.1 - 0.16 11.1 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 AMD21556.1 - 0.18 11.6 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RRM_1 PF00076.22 AMD21557.1 - 1.1e-06 28.4 0.1 1.8e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 AMD21557.1 - 0.00014 22.3 1.4 0.00036 21.0 1.4 1.7 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 SET_assoc PF11767.8 AMD21557.1 - 0.0019 17.8 0.2 0.0033 17.0 0.2 1.4 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Limkain-b1 PF11608.8 AMD21557.1 - 0.0036 17.3 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 Limkain b1 PFU PF09070.11 AMD21558.1 - 1.9e-41 140.8 0.5 4.9e-41 139.5 0.5 1.7 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 AMD21558.1 - 5.3e-36 124.3 0.8 7.5e-36 123.8 0.8 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 AMD21558.1 - 1.9e-27 94.9 26.0 1.7e-07 31.8 0.1 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat Mcl1_mid PF12341.8 AMD21558.1 - 0.0057 16.0 0.1 0.77 9.0 0.0 3.3 2 1 1 3 3 3 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 AMD21558.1 - 0.054 13.8 0.1 6.5 7.1 0.0 3.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Syja_N PF02383.18 AMD21559.1 - 9.5e-86 288.0 1.1 1.5e-85 287.3 1.1 1.3 1 0 0 1 1 1 1 SacI homology domain IGPS PF00218.21 AMD21560.1 - 1.3e-85 286.6 0.0 3.1e-85 285.4 0.1 1.6 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 AMD21560.1 - 4.8e-48 163.5 0.1 7.5e-48 162.8 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AMD21560.1 - 1e-08 35.2 0.2 2.1e-07 30.9 0.2 2.3 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 AMD21560.1 - 0.0016 18.2 0.1 0.0036 17.1 0.1 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain TPD52 PF04201.15 AMD21560.1 - 0.04 13.5 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 Tumour protein D52 family Septin PF00735.18 AMD21561.1 - 1.2e-107 359.3 0.0 2.2e-107 358.5 0.0 1.4 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AMD21561.1 - 7e-07 29.3 0.0 1.6e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AMD21561.1 - 3.1e-05 24.1 7.7 0.017 15.2 0.1 2.9 3 0 0 3 3 3 2 Dynamin family ABC_tran PF00005.27 AMD21561.1 - 5.3e-05 23.7 1.5 8.5e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 AMD21561.1 - 0.00035 20.0 0.0 0.00035 20.0 0.0 2.0 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 AMD21561.1 - 0.00091 19.2 1.8 0.00091 19.2 1.8 2.9 3 1 0 3 3 3 1 RsgA GTPase IIGP PF05049.13 AMD21561.1 - 0.0065 15.6 0.0 0.014 14.5 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.6 AMD21561.1 - 0.02 15.2 0.2 0.061 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 AMD21561.1 - 0.035 13.8 0.0 0.08 12.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 AMD21561.1 - 0.06 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 AMD21561.1 - 0.064 12.4 4.3 0.082 12.1 0.1 2.8 4 0 0 4 4 4 0 G-protein alpha subunit cobW PF02492.19 AMD21561.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Pox_A32 PF04665.12 AMD21561.1 - 0.12 11.8 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_23 PF13476.6 AMD21561.1 - 0.15 12.6 10.1 3.3 8.2 5.0 2.4 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 AMD21561.1 - 0.32 11.1 2.3 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain Gasdermin_C PF17708.1 AMD21561.1 - 1.6 8.8 7.4 3.3 7.8 4.3 2.2 2 0 0 2 2 2 0 Gasdermin PUB domain Gly_transf_sug PF04488.15 AMD21562.1 - 5.2e-12 46.3 0.0 1.5e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif HSBP1 PF06825.12 AMD21562.1 - 0.059 13.2 1.7 0.15 11.9 1.7 1.7 1 0 0 1 1 1 0 Heat shock factor binding protein 1 DUF4446 PF14584.6 AMD21562.1 - 0.15 12.1 0.7 0.26 11.3 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) HIP1_clath_bdg PF16515.5 AMD21562.1 - 0.54 10.9 7.2 0.98 10.1 7.2 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Mog1 PF04603.12 AMD21563.1 - 9.4e-39 132.9 0.0 1.2e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein ThiF PF00899.21 AMD21564.1 - 1.1e-101 339.3 0.0 2e-71 240.2 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 AMD21564.1 - 5.6e-85 285.3 0.0 8.9e-85 284.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 AMD21564.1 - 1.5e-34 118.6 0.0 3.7e-34 117.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 AMD21564.1 - 2.1e-28 98.3 0.2 4.5e-28 97.3 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 AMD21564.1 - 7.3e-25 87.0 0.3 1.9e-24 85.6 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle NAD_binding_7 PF13241.6 AMD21564.1 - 0.31 11.5 1.6 3.4 8.1 0.0 3.3 3 1 0 3 3 3 0 Putative NAD(P)-binding ABC_membrane PF00664.23 AMD21565.1 - 1.5e-89 300.3 40.3 6e-49 167.1 16.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 AMD21565.1 - 1.3e-59 200.6 0.4 1.8e-30 106.3 0.0 2.9 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 AMD21565.1 - 1.9e-18 66.7 3.6 3.5e-07 29.9 0.0 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AMD21565.1 - 9.4e-08 31.7 0.1 0.007 16.1 0.1 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 AMD21565.1 - 1.7e-06 27.1 0.5 0.03 13.1 0.0 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 AMD21565.1 - 3.3e-06 27.4 2.7 0.084 13.1 0.2 3.9 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 AMD21565.1 - 4.8e-06 26.6 0.2 0.057 13.3 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 AMD21565.1 - 6.5e-06 26.2 13.3 0.42 10.4 0.2 4.5 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 AMD21565.1 - 5.3e-05 23.4 0.4 0.027 14.6 0.0 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_5 PF07728.14 AMD21565.1 - 5.9e-05 23.1 0.1 1.3 9.0 0.0 4.3 5 0 0 5 5 5 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AMD21565.1 - 8.4e-05 23.0 1.7 0.71 10.2 0.0 3.5 3 1 0 3 3 2 2 AAA ATPase domain AAA_15 PF13175.6 AMD21565.1 - 0.00017 21.4 0.3 0.082 12.6 0.5 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 AMD21565.1 - 0.00023 21.7 0.1 0.2 12.2 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AMD21565.1 - 0.00025 20.8 0.6 0.047 13.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 AMD21565.1 - 0.00038 21.0 0.0 0.11 13.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AMD21565.1 - 0.00054 19.3 0.0 0.65 9.2 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.23 AMD21565.1 - 0.0015 18.6 2.1 1.4 9.1 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase IstB_IS21 PF01695.17 AMD21565.1 - 0.0027 17.4 0.2 19 5.0 0.0 4.2 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_33 PF13671.6 AMD21565.1 - 0.0043 17.2 0.1 2.9 8.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 AMD21565.1 - 0.0046 17.3 0.9 0.97 9.8 0.0 3.1 3 0 0 3 3 2 1 RNA helicase APS_kinase PF01583.20 AMD21565.1 - 0.0077 16.1 0.1 3.1 7.7 0.0 2.5 2 0 0 2 2 2 1 Adenylylsulphate kinase PduV-EutP PF10662.9 AMD21565.1 - 0.02 14.7 0.1 4.4 7.0 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CobA_CobO_BtuR PF02572.15 AMD21565.1 - 0.021 15.1 0.1 16 5.7 0.1 3.3 3 0 0 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP NACHT PF05729.12 AMD21565.1 - 0.031 14.2 8.0 4 7.3 0.2 4.0 3 1 1 4 4 4 0 NACHT domain T2SSE PF00437.20 AMD21565.1 - 0.033 13.2 0.1 3.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.6 AMD21565.1 - 0.034 13.9 0.1 4 7.1 0.0 3.3 3 1 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 AMD21565.1 - 0.049 13.3 0.0 6.6 6.4 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain Ploopntkinase3 PF18751.1 AMD21565.1 - 0.055 13.4 0.0 5.5 6.9 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 PRK PF00485.18 AMD21565.1 - 0.057 13.2 0.0 3.2 7.5 0.0 2.8 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family Roc PF08477.13 AMD21565.1 - 0.068 13.4 0.3 5.2 7.3 0.0 2.9 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Pox_A32 PF04665.12 AMD21565.1 - 0.073 12.5 0.3 8.4 5.8 0.1 2.7 3 0 0 3 3 2 0 Poxvirus A32 protein Dynamin_N PF00350.23 AMD21565.1 - 0.073 13.1 1.1 6.5 6.8 0.2 2.8 2 0 0 2 2 2 0 Dynamin family AAA_13 PF13166.6 AMD21565.1 - 0.081 11.6 0.8 0.2 10.3 0.1 1.9 3 0 0 3 3 3 0 AAA domain DUF3987 PF13148.6 AMD21565.1 - 0.16 10.9 0.0 17 4.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) CbiA PF01656.23 AMD21565.1 - 0.18 11.9 0.1 9.4 6.3 0.0 2.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.6 AMD21565.1 - 0.19 11.3 0.2 12 5.4 0.1 3.2 3 0 0 3 3 3 0 AAA domain PEMT PF04191.13 AMD21566.1 - 2.9e-33 114.5 2.6 2.9e-33 114.5 2.6 1.7 2 0 0 2 2 2 1 Phospholipid methyltransferase Glyco_hydro_125 PF06824.11 AMD21567.1 - 9e-171 568.3 0.0 1.1e-170 568.1 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) EMC3_TMCO1 PF01956.16 AMD21568.1 - 1.6e-53 180.9 2.0 2e-53 180.6 2.0 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Flp1_like PF16982.5 AMD21568.1 - 0.03 13.7 1.6 0.066 12.6 1.6 1.5 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain ATP_bind_1 PF03029.17 AMD21569.1 - 1e-81 274.3 0.3 1.7e-81 273.6 0.3 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 AMD21569.1 - 1.3e-08 34.7 3.5 3.7e-08 33.1 0.4 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 AMD21569.1 - 0.00011 22.0 1.8 0.00018 21.3 0.0 2.2 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 AMD21569.1 - 0.00012 22.3 0.0 0.00025 21.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 AMD21569.1 - 0.00061 19.3 0.1 0.017 14.7 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 AMD21569.1 - 0.00081 18.4 0.1 0.86 8.5 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 AMD21569.1 - 0.00091 19.3 0.0 0.016 15.3 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 AMD21569.1 - 0.0011 19.2 0.0 0.0057 16.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AMD21569.1 - 0.0018 18.2 0.2 0.0041 17.0 0.0 1.7 2 0 0 2 2 1 1 NACHT domain AAA_16 PF13191.6 AMD21569.1 - 0.0062 16.9 0.1 0.019 15.4 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain PduV-EutP PF10662.9 AMD21569.1 - 0.0065 16.2 0.2 0.16 11.7 0.0 2.7 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 AMD21569.1 - 0.01 15.0 0.1 0.084 12.0 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.19 AMD21569.1 - 0.012 15.2 0.2 0.12 12.0 0.2 2.4 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 AMD21569.1 - 0.013 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 AMD21569.1 - 0.017 14.9 0.0 0.35 10.6 0.0 2.5 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Roc PF08477.13 AMD21569.1 - 0.018 15.2 0.0 1.2 9.4 0.0 2.7 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 AMD21569.1 - 0.026 14.5 2.6 6.9 6.5 0.2 3.6 2 2 1 3 3 3 0 RsgA GTPase PRK PF00485.18 AMD21569.1 - 0.028 14.2 0.1 0.31 10.7 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family SRP54 PF00448.22 AMD21569.1 - 0.036 13.7 0.0 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 AMD21569.1 - 0.036 14.6 0.3 0.12 12.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain Arf PF00025.21 AMD21569.1 - 0.045 13.2 0.1 1.8 8.0 0.0 2.7 2 1 0 2 2 2 0 ADP-ribosylation factor family AAA_7 PF12775.7 AMD21569.1 - 0.066 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 AMD21569.1 - 0.087 13.2 0.0 1.9 8.9 0.0 2.8 3 0 0 3 3 2 0 RNA helicase SRPRB PF09439.10 AMD21569.1 - 0.16 11.4 4.7 0.43 10.0 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit UreE_N PF02814.15 AMD21569.1 - 0.18 11.4 1.4 0.64 9.7 0.6 2.1 2 0 0 2 2 2 0 UreE urease accessory protein, N-terminal domain PAC2 PF09754.9 AMD21570.1 - 1.7e-23 83.7 0.0 2.6e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 PAC2 family HEAT_2 PF13646.6 AMD21571.1 - 2.7e-32 111.0 0.5 5.8e-15 55.5 0.0 3.4 3 1 1 4 4 4 2 HEAT repeats HEAT_PBS PF03130.16 AMD21571.1 - 3.5e-18 64.4 0.0 7.3e-05 23.1 0.0 6.2 7 0 0 7 7 7 3 PBS lyase HEAT-like repeat HEAT PF02985.22 AMD21571.1 - 1.4e-12 46.7 0.0 0.93 9.9 0.0 6.5 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 AMD21571.1 - 1.8e-06 28.3 0.7 6.4 7.4 0.0 5.2 3 2 2 5 5 5 3 HEAT-like repeat Cnd1 PF12717.7 AMD21571.1 - 0.0017 18.4 0.4 11 6.1 0.0 3.9 2 2 3 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AMD21571.1 - 0.012 15.6 0.3 0.61 10.2 0.0 3.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Cohesin_HEAT PF12765.7 AMD21571.1 - 0.027 14.8 0.5 0.51 10.7 0.1 3.0 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion SRP_TPR_like PF17004.5 AMD21571.1 - 0.057 13.4 0.0 0.35 10.9 0.1 2.1 2 1 0 2 2 2 0 Putative TPR-like repeat Ham1p_like PF01725.16 AMD21572.1 - 3.7e-52 177.0 0.0 4.1e-52 176.8 0.0 1.0 1 0 0 1 1 1 1 Ham1 family FAM193_C PF15914.5 AMD21572.1 - 0.15 11.8 0.8 0.39 10.5 0.8 1.7 1 1 0 1 1 1 0 FAM193 family C-terminal Xpo1 PF08389.12 AMD21573.1 - 3.3e-43 147.3 0.7 3e-42 144.2 0.1 2.8 2 0 0 2 2 2 1 Exportin 1-like protein DUF1345 PF07077.11 AMD21573.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) DUF3861 PF12977.7 AMD21574.1 - 0.33 11.1 2.2 0.4 10.9 0.6 2.0 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) DUF1840 PF08895.11 AMD21574.1 - 2.6 8.4 9.1 20 5.6 4.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Rep_fac_C PF08542.11 AMD21575.1 - 6.4e-18 65.0 0.0 1.3e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 AMD21575.1 - 4.6e-16 59.5 0.0 9.3e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AMD21575.1 - 7.2e-14 51.9 0.1 8.7e-13 48.4 0.0 2.4 2 1 0 2 2 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 AMD21575.1 - 2.6e-10 40.5 0.0 6.7e-10 39.2 0.0 1.9 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 AMD21575.1 - 1.5e-05 25.3 0.0 0.00014 22.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AMD21575.1 - 2.5e-05 24.1 0.0 7.2e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AMD21575.1 - 5.8e-05 23.5 0.1 0.003 18.0 0.0 2.5 2 1 1 3 3 2 1 AAA ATPase domain AAA_11 PF13086.6 AMD21575.1 - 7e-05 22.7 0.1 0.00015 21.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AMD21575.1 - 0.00011 21.7 0.0 0.0035 16.8 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 AMD21575.1 - 0.00016 21.9 0.1 0.00043 20.6 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain DUF815 PF05673.13 AMD21575.1 - 0.00057 19.1 0.0 0.00097 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ResIII PF04851.15 AMD21575.1 - 0.00097 19.2 0.1 0.0071 16.4 0.0 2.3 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 AMD21575.1 - 0.0016 18.5 0.0 0.0068 16.4 0.0 2.1 2 1 1 3 3 3 1 AAA domain AAA_30 PF13604.6 AMD21575.1 - 0.0028 17.4 0.0 0.0074 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD21575.1 - 0.0032 17.8 0.0 0.015 15.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 AMD21575.1 - 0.0051 16.3 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 AMD21575.1 - 0.0055 16.4 0.0 0.012 15.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain TrwB_AAD_bind PF10412.9 AMD21575.1 - 0.0094 14.9 0.2 3 6.7 0.0 2.3 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain AAA_23 PF13476.6 AMD21575.1 - 0.0094 16.5 0.0 0.015 15.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AMD21575.1 - 0.026 14.5 0.1 0.14 12.1 0.1 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49_C PF17856.1 AMD21575.1 - 0.03 14.4 0.3 0.075 13.2 0.3 1.6 1 0 0 1 1 1 0 TIP49 AAA-lid domain Propeptide_C1 PF08127.13 AMD21575.1 - 0.042 13.7 0.2 4.5 7.2 0.1 2.9 3 0 0 3 3 3 0 Peptidase family C1 propeptide DUF2075 PF09848.9 AMD21575.1 - 0.055 12.7 0.0 0.2 10.9 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 AMD21575.1 - 0.07 13.0 0.0 0.72 9.7 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 AMD21575.1 - 0.085 13.4 0.0 0.35 11.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 AMD21575.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 AMD21575.1 - 0.14 12.5 0.0 0.32 11.4 0.0 1.7 1 1 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 AMD21575.1 - 0.16 12.5 0.1 4.4 7.8 0.0 2.6 2 1 0 2 2 2 0 ABC transporter Yae1_N PF09811.9 AMD21576.1 - 5.5e-12 45.2 0.2 7.2e-12 44.8 0.2 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Peptidase_M44 PF03410.13 AMD21576.1 - 0.038 12.6 0.0 0.05 12.2 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox FAT PF02259.23 AMD21577.1 - 8.2e-139 462.6 2.4 8.2e-139 462.6 2.4 2.6 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 AMD21577.1 - 2.8e-72 243.5 0.0 5.4e-72 242.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 AMD21577.1 - 3.7e-68 228.5 22.6 1.3e-65 220.2 0.9 6.4 7 1 1 8 8 8 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 AMD21577.1 - 3.5e-44 149.3 3.3 1.2e-43 147.6 0.5 3.4 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain FATC PF02260.20 AMD21577.1 - 2.1e-17 62.6 0.3 5e-17 61.4 0.3 1.7 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 AMD21577.1 - 7.1e-10 39.1 2.8 0.12 12.7 0.0 7.1 6 1 0 6 6 5 3 HEAT repeats HEAT_EZ PF13513.6 AMD21577.1 - 2.6e-06 27.8 2.3 0.061 13.9 0.0 7.6 6 1 2 8 8 8 1 HEAT-like repeat HEAT PF02985.22 AMD21577.1 - 2.9e-05 23.9 10.4 0.51 10.7 0.0 8.0 9 0 0 9 9 9 1 HEAT repeat IFRD PF05004.13 AMD21577.1 - 0.00016 20.9 1.4 0.1 11.7 0.2 4.3 4 0 0 4 4 4 1 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 AMD21577.1 - 0.057 14.0 9.2 22 5.8 0.0 5.9 6 1 0 6 6 6 0 Vacuolar 14 Fab1-binding region DUF727 PF05303.12 AMD21577.1 - 0.071 13.2 0.2 0.27 11.3 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF727) Actin PF00022.19 AMD21578.1 - 3.4e-87 292.7 0.0 1.3e-84 284.2 0.0 2.1 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AMD21578.1 - 3e-05 23.0 0.0 0.02 13.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 AMD21578.1 - 0.0011 19.3 0.0 0.0036 17.7 0.0 1.9 1 1 0 1 1 1 1 Cell division protein FtsA Cpn60_TCP1 PF00118.24 AMD21579.1 - 1e-147 492.8 4.1 1.1e-147 492.6 4.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pfg27 PF09216.10 AMD21579.1 - 0.049 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Pfg27 TFIIS_C PF01096.18 AMD21580.1 - 2.2e-18 65.8 2.1 2.2e-18 65.8 2.1 3.2 4 0 0 4 4 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 AMD21580.1 - 3.7e-09 36.3 9.5 2.2e-07 30.6 0.2 2.9 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 AMD21580.1 - 0.00034 20.6 7.0 0.031 14.3 0.2 2.9 2 1 0 2 2 2 2 Double zinc ribbon zf-ribbon_3 PF13248.6 AMD21580.1 - 0.0043 16.4 12.9 6.3 6.3 0.0 4.4 4 0 0 4 4 4 0 zinc-ribbon domain IBR PF01485.21 AMD21580.1 - 0.015 15.5 5.7 1.2 9.4 0.2 2.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Baculo_p48 PF04878.13 AMD21580.1 - 0.024 13.6 0.0 0.026 13.5 0.0 1.1 1 0 0 1 1 1 0 Baculovirus P48 protein TackOD1 PF18551.1 AMD21580.1 - 0.026 14.2 4.3 1.2 8.8 0.2 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Zn_Tnp_IS1595 PF12760.7 AMD21580.1 - 0.035 14.1 5.9 0.056 13.4 1.0 2.5 2 2 1 3 3 3 0 Transposase zinc-ribbon domain C1_1 PF00130.22 AMD21580.1 - 0.053 13.4 3.6 3.2 7.7 0.2 2.6 2 2 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_2 PF13465.6 AMD21580.1 - 0.058 13.8 5.2 4.3 7.9 0.2 3.5 3 1 0 3 3 3 0 Zinc-finger double domain zf-TFIIB PF13453.6 AMD21580.1 - 0.06 12.7 2.1 0.15 11.4 0.7 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-CRD PF17979.1 AMD21580.1 - 0.069 13.3 3.7 0.25 11.5 3.7 1.7 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions zinc_ribbon_2 PF13240.6 AMD21580.1 - 0.076 12.8 10.9 13 5.7 1.8 4.1 3 1 0 3 3 3 0 zinc-ribbon domain Baculo_LEF5_C PF11792.8 AMD21580.1 - 0.14 11.9 0.0 0.14 11.9 0.0 3.1 4 0 0 4 4 4 0 Baculoviridae late expression factor 5 C-terminal domain zf-C2H2_3 PF13878.6 AMD21580.1 - 0.2 11.5 9.1 2.4 8.0 0.0 3.3 2 1 1 3 3 3 0 zinc-finger of acetyl-transferase ESCO zinc-ribbons_6 PF07191.12 AMD21580.1 - 0.28 11.2 7.3 3.6 7.6 0.4 2.8 2 2 0 2 2 2 0 zinc-ribbons zf-RING_5 PF14634.6 AMD21580.1 - 0.41 10.6 6.1 3.5 7.6 0.4 2.9 3 0 0 3 3 3 0 zinc-RING finger domain DpnI PF06044.12 AMD21580.1 - 0.71 9.5 5.1 7.4 6.2 0.1 2.1 1 1 0 2 2 2 0 Dam-replacing family zf-AN1 PF01428.16 AMD21580.1 - 0.76 10.0 8.1 14 5.9 0.9 3.3 3 1 0 3 3 3 0 AN1-like Zinc finger zf-C4_Topoisom PF01396.19 AMD21580.1 - 0.83 9.5 9.0 0.24 11.2 2.0 3.1 2 2 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zinc_ribbon_4 PF13717.6 AMD21580.1 - 1.5 8.8 8.6 13 5.8 0.1 3.6 4 0 0 4 4 4 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AMD21580.1 - 1.5 8.8 7.8 13 5.8 0.2 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain Rubredoxin PF00301.20 AMD21580.1 - 1.5 8.9 7.4 5.8 7.0 0.8 3.3 3 0 0 3 3 3 0 Rubredoxin PHD PF00628.29 AMD21580.1 - 2.8 7.9 10.0 14 5.7 1.1 2.9 2 2 1 3 3 3 0 PHD-finger Elf1 PF05129.13 AMD21580.1 - 3.8 7.6 7.1 1.3 9.1 0.7 2.8 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf_UBZ PF18439.1 AMD21580.1 - 4 7.1 11.7 2 8.1 0.1 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger PADR1 PF08063.12 AMD21580.1 - 6.1 6.7 10.0 22 5.0 4.7 3.4 3 1 0 3 3 3 0 PADR1 (NUC008) domain zf-RRN7 PF11781.8 AMD21580.1 - 7.1 6.4 10.5 20 5.0 0.0 3.9 4 0 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 AMD21580.1 - 7.2 6.2 15.9 4.6 6.8 4.8 3.2 2 2 1 3 3 3 0 TFIIB zinc-binding zf-Mss51 PF13824.6 AMD21580.1 - 8.1 6.6 8.4 0.38 10.9 1.2 2.5 3 1 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 LicD PF04991.13 AMD21581.1 - 1e-41 143.6 0.8 1e-41 143.6 0.8 3.4 4 0 0 4 4 4 1 LicD family Exonuc_VII_L PF02601.15 AMD21581.1 - 0.17 11.4 17.5 0.38 10.3 17.5 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit GAGA_bind PF06217.12 AMD21581.1 - 7.6 6.7 15.1 13 5.9 15.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CN_hydrolase PF00795.22 AMD21582.1 - 6.2e-17 61.8 0.0 2.3e-15 56.6 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase HLH PF00010.26 AMD21583.1 - 4.4e-12 45.8 3.5 8.5e-12 44.8 3.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2465 PF10239.9 AMD21583.1 - 0.015 14.6 6.2 0.023 13.9 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) Sec66 PF09802.9 AMD21583.1 - 0.033 13.8 3.6 0.064 12.8 3.6 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 RasGEF PF00617.19 AMD21583.1 - 0.033 14.4 1.8 0.53 10.5 2.3 2.0 2 0 0 2 2 2 0 RasGEF domain CDC45 PF02724.14 AMD21583.1 - 0.1 10.8 14.8 0.12 10.7 14.8 1.2 1 0 0 1 1 1 0 CDC45-like protein CbiG_C PF01890.16 AMD21583.1 - 0.21 12.1 3.3 1.1 9.8 0.1 2.5 2 1 1 3 3 3 0 Cobalamin synthesis G C-terminus Pkinase PF00069.25 AMD21584.1 - 6.7e-40 137.1 0.0 1.1e-39 136.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21584.1 - 7.1e-11 41.9 0.0 1.9e-10 40.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 AMD21584.1 - 0.0018 17.7 0.0 0.0033 16.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 AMD21584.1 - 0.0088 15.7 5.5 0.19 11.3 0.0 2.8 2 1 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 AMD21584.1 - 0.028 13.7 0.0 0.078 12.3 0.0 1.8 1 1 0 1 1 1 0 Kinase-like AAA PF00004.29 AMD21585.1 - 3.4e-53 179.6 0.0 8.8e-44 149.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 AMD21585.1 - 3e-22 78.8 0.0 8e-22 77.4 0.0 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 AMD21585.1 - 1.4e-14 53.6 0.1 1.9e-10 40.4 0.1 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 AMD21585.1 - 6.6e-14 52.6 1.8 1.7e-06 28.5 0.0 4.5 3 1 1 4 4 4 2 AAA ATPase domain NACHT PF05729.12 AMD21585.1 - 1.7e-08 34.6 0.7 4.2e-05 23.5 0.0 3.5 3 1 0 3 3 3 1 NACHT domain Bac_DnaA PF00308.18 AMD21585.1 - 9.3e-08 32.2 0.0 1.2e-05 25.2 0.0 3.0 2 2 0 2 2 2 1 Bacterial dnaA protein AAA_22 PF13401.6 AMD21585.1 - 2.9e-07 30.8 0.1 0.12 12.7 0.0 4.1 2 2 1 3 3 3 2 AAA domain AAA_2 PF07724.14 AMD21585.1 - 3.6e-06 27.2 0.0 0.0033 17.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) ATPase_2 PF01637.18 AMD21585.1 - 3.7e-06 27.0 0.0 0.0005 20.1 0.0 2.6 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 AMD21585.1 - 6.6e-06 26.2 0.0 0.19 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.22 AMD21585.1 - 7.5e-05 22.0 0.0 0.037 13.2 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_5 PF07728.14 AMD21585.1 - 9.4e-05 22.4 0.1 1 9.4 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AMD21585.1 - 0.00022 21.0 0.0 0.0069 16.1 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 AMD21585.1 - 0.00031 20.1 0.1 0.13 11.5 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 AMD21585.1 - 0.00031 20.9 0.0 0.032 14.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 AMD21585.1 - 0.00059 20.2 0.0 1.3 9.5 0.0 3.1 3 0 0 3 3 3 1 RNA helicase IstB_IS21 PF01695.17 AMD21585.1 - 0.0016 18.2 0.1 0.78 9.5 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein DUF2075 PF09848.9 AMD21585.1 - 0.003 16.8 0.0 0.66 9.1 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Molydop_binding PF01568.21 AMD21585.1 - 0.0036 17.3 0.0 0.016 15.2 0.0 2.0 2 0 0 2 2 2 1 Molydopterin dinucleotide binding domain AAA_3 PF07726.11 AMD21585.1 - 0.012 15.5 0.0 0.53 10.2 0.0 2.7 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 AMD21585.1 - 0.013 15.1 0.2 4 7.0 0.0 3.6 4 0 0 4 4 4 0 AAA domain TsaE PF02367.17 AMD21585.1 - 0.013 15.5 0.0 0.5 10.4 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 AMD21585.1 - 0.015 14.5 0.0 2.8 7.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 AMD21585.1 - 0.021 15.2 0.0 0.44 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 AMD21585.1 - 0.022 14.1 0.0 0.25 10.6 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Viral_helicase1 PF01443.18 AMD21585.1 - 0.027 14.2 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 AMD21585.1 - 0.032 13.6 0.7 0.91 8.9 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AMD21585.1 - 0.087 13.4 0.0 0.28 11.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain NTPase_1 PF03266.15 AMD21585.1 - 0.093 12.6 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_17 PF13207.6 AMD21585.1 - 0.11 12.9 0.1 0.51 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 AMD21585.1 - 0.12 12.1 0.1 18 5.0 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 AMD21585.1 - 0.13 11.7 0.0 17 4.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region TniB PF05621.11 AMD21585.1 - 0.13 11.6 0.0 2.6 7.4 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein Clat_adaptor_s PF01217.20 AMD21586.1 - 1e-44 151.9 0.1 1.1e-44 151.8 0.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Thymidylate_kin PF02223.17 AMD21587.1 - 9.4e-45 152.6 0.0 1.1e-44 152.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 AMD21587.1 - 0.003 17.8 0.0 0.0041 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD21587.1 - 0.026 15.1 0.0 0.043 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AMD21587.1 - 0.027 14.6 0.0 0.047 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain SUR7 PF06687.12 AMD21588.1 - 4.7e-36 124.4 4.7 6.1e-36 124.1 4.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family Guanylate_cyc_2 PF09778.9 AMD21588.1 - 0.068 12.5 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 Guanylylate cyclase Hit1_C PF18268.1 AMD21589.1 - 5.1e-38 129.1 0.1 5.1e-38 129.1 0.1 1.6 2 0 0 2 2 2 1 Hit1 C-terminal zf-HIT PF04438.16 AMD21589.1 - 4.3e-09 36.1 11.4 8.2e-09 35.2 11.4 1.4 1 0 0 1 1 1 1 HIT zinc finger PolC_DP2 PF03833.13 AMD21589.1 - 0.16 9.8 3.0 0.17 9.7 3.0 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-MYND PF01753.18 AMD21589.1 - 0.87 9.7 11.7 1.6 8.9 11.7 1.4 1 0 0 1 1 1 0 MYND finger Suc_Fer-like PF06999.12 AMD21590.1 - 5.1e-37 127.6 0.0 6.1e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like MMS1_N PF10433.9 AMD21591.1 - 1.8e-81 274.3 0.1 9.9e-80 268.5 0.0 2.5 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 AMD21591.1 - 2.3e-49 168.5 0.5 1.1e-47 162.9 0.1 3.3 3 1 0 3 3 3 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 AMD21591.1 - 0.0074 16.6 2.9 1.5 9.2 0.0 5.0 5 1 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Myc_N PF01056.18 AMD21591.1 - 0.03 14.2 10.5 0.7 9.7 6.7 2.2 2 0 0 2 2 2 0 Myc amino-terminal region Vfa1 PF08432.10 AMD21591.1 - 3.1 8.1 7.3 11 6.3 6.8 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Pox_Ag35 PF03286.14 AMD21591.1 - 4 7.2 13.7 0.75 9.6 7.3 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein RNA_pol_3_Rpc31 PF11705.8 AMD21591.1 - 7.2 6.8 24.3 0.35 11.1 16.9 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Gsf2 PF11055.8 AMD21592.1 - 8.6e-165 548.0 0.6 9.9e-165 547.8 0.6 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 DUF2087 PF09860.9 AMD21593.1 - 0.0075 16.4 0.4 1.8 8.8 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2087) LRR_4 PF12799.7 AMD21594.1 - 7.3e-05 23.1 17.8 0.25 11.8 2.1 6.2 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) CDC27 PF09507.10 AMD21594.1 - 0.012 15.0 20.3 0.016 14.6 20.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Soyouz_module PF14313.6 AMD21594.1 - 0.017 14.9 0.1 0.069 12.9 0.0 2.0 2 0 0 2 2 2 0 N-terminal region of Paramyxovirinae phosphoprotein (P) BUD22 PF09073.10 AMD21594.1 - 6.2 6.1 19.5 8.3 5.6 19.5 1.1 1 0 0 1 1 1 0 BUD22 TPR_15 PF13429.6 AMD21595.1 - 0.0011 18.2 0.1 3.3 6.8 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat REV1_C PF16727.5 AMD21595.1 - 0.03 14.7 0.1 0.1 13.0 0.1 1.9 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain NRDE-2 PF08424.10 AMD21595.1 - 0.071 12.2 3.2 0.074 12.2 0.2 2.4 1 1 1 2 2 2 0 NRDE-2, necessary for RNA interference Mad3_BUB1_I PF08311.12 AMD21595.1 - 8.6 6.4 9.6 47 4.0 0.2 4.8 4 3 1 5 5 5 0 Mad3/BUB1 homology region 1 Atg31 PF09795.9 AMD21597.1 - 7.5e-21 74.8 8.0 1.8e-20 73.5 8.0 1.6 1 1 0 1 1 1 1 Autophagy-related protein 31 DEAD PF00270.29 AMD21598.1 - 1.5e-43 148.6 2.4 1.5e-43 148.6 2.4 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21598.1 - 7.6e-33 113.2 0.2 5.2e-31 107.3 0.0 2.9 2 1 1 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 AMD21598.1 - 4.5e-05 23.8 0.3 0.0012 19.2 0.4 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AMD21598.1 - 0.00011 22.0 0.2 0.00018 21.3 0.2 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 AMD21598.1 - 0.00016 21.7 0.1 0.00031 20.8 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AMD21598.1 - 0.017 15.4 0.2 0.047 14.0 0.2 1.7 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 AMD21598.1 - 0.027 14.3 0.1 0.05 13.5 0.1 1.6 1 1 0 1 1 1 0 Helicase Flavi_DEAD PF07652.14 AMD21598.1 - 0.081 12.9 1.5 0.12 12.4 0.1 2.0 2 1 0 2 2 2 0 Flavivirus DEAD domain PhoH PF02562.16 AMD21598.1 - 0.31 10.5 3.1 0.96 8.9 3.1 1.9 1 1 0 1 1 1 0 PhoH-like protein UvrD-helicase PF00580.21 AMD21598.1 - 0.33 10.4 1.9 0.4 10.1 1.0 1.5 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain PRK PF00485.18 AMD21599.1 - 2.1e-08 34.1 0.1 3.7e-08 33.3 0.1 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Glyco_hydro_31 PF01055.26 AMD21599.1 - 0.14 11.3 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 AA_permease PF00324.21 AMD21601.1 - 4.6e-112 375.1 38.1 5.8e-112 374.7 38.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD21601.1 - 6.4e-37 127.4 40.3 7.9e-37 127.1 40.3 1.1 1 0 0 1 1 1 1 Amino acid permease INSIG PF07281.12 AMD21601.1 - 0.0099 15.5 0.9 0.019 14.6 0.3 1.7 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) Bac_surface_Ag PF01103.23 AMD21602.1 - 3.1e-25 89.3 2.1 3.8e-25 89.0 2.1 1.1 1 0 0 1 1 1 1 Surface antigen Yop-YscD_cpl PF16697.5 AMD21603.1 - 3.3e-06 27.3 0.0 8.4e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 AMD21603.1 - 1.6e-05 25.1 0.0 4.3e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 FHA domain BRCT PF00533.26 AMD21603.1 - 0.0087 16.4 0.0 0.079 13.3 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain FHA_2 PF17913.1 AMD21603.1 - 0.026 14.8 0.1 0.13 12.6 0.0 2.2 2 0 0 2 2 2 0 FHA domain Aldo_ket_red PF00248.21 AMD21604.1 - 1.7e-48 165.3 0.0 1.4e-46 159.1 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family Kei1 PF08552.11 AMD21605.1 - 7.9e-35 120.5 15.4 2.8e-30 105.6 9.3 2.0 1 1 1 2 2 2 2 Inositolphosphorylceramide synthase subunit Kei1 RIO1 PF01163.22 AMD21606.1 - 1.2e-71 240.2 0.8 1.2e-71 240.2 0.8 2.5 3 0 0 3 3 3 1 RIO1 family APH PF01636.23 AMD21606.1 - 0.096 12.6 0.0 2 8.3 0.0 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family DNA_pol_phi PF04931.13 AMD21606.1 - 5.3 5.0 26.0 10 4.1 26.0 1.4 1 0 0 1 1 1 0 DNA polymerase phi TLD PF07534.16 AMD21607.1 - 3.4e-27 95.4 0.0 3.4e-26 92.1 0.0 2.3 1 1 0 1 1 1 1 TLD NUC153 PF08159.12 AMD21608.1 - 1.3e-12 47.3 3.4 1.3e-12 47.3 3.4 3.2 3 0 0 3 3 3 2 NUC153 domain MEF2_binding PF09047.10 AMD21608.1 - 0.052 13.4 2.3 0.15 11.9 2.3 1.7 1 0 0 1 1 1 0 MEF2 binding MSC PF09402.10 AMD21609.1 - 2.5e-108 362.5 1.2 2.5e-108 362.5 1.2 1.9 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain HeH PF12949.7 AMD21609.1 - 1.2e-13 50.5 0.5 6.3e-13 48.2 0.5 2.4 1 0 0 1 1 1 1 HeH/LEM domain Cytochrome_P460 PF16694.5 AMD21609.1 - 0.014 15.7 1.6 5.4 7.4 0.0 2.7 2 0 0 2 2 2 0 Cytochrome P460 DUF3419 PF11899.8 AMD21609.1 - 0.048 12.8 0.1 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3419) TraF PF13728.6 AMD21609.1 - 0.09 12.6 3.5 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 F plasmid transfer operon protein HECT PF00632.25 AMD21610.1 - 6.6e-91 305.0 0.4 3.2e-90 302.7 0.1 2.3 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 AMD21610.1 - 6.1e-57 193.7 11.6 8.4e-56 189.9 7.4 3.3 2 1 0 2 2 2 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 AMD21610.1 - 2.9e-51 174.6 10.0 5.6e-51 173.7 0.0 3.6 3 0 0 3 3 3 1 Domain of Unknown Function (DUF913) UBM PF14377.6 AMD21610.1 - 1.4e-12 46.6 5.4 4e-08 32.4 0.1 3.0 3 0 0 3 3 3 2 Ubiquitin binding region Rad52_Rad22 PF04098.15 AMD21611.1 - 6.5e-56 188.5 0.0 1.2e-55 187.6 0.0 1.5 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ndc1_Nup PF09531.10 AMD21612.1 - 1.9e-92 311.0 21.3 2.5e-91 307.2 21.3 2.0 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Na_H_Exchanger PF00999.21 AMD21613.1 - 2.2e-68 230.8 36.4 2.8e-68 230.4 36.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DinB PF05163.12 AMD21613.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 DinB family Guanylate_kin PF00625.21 AMD21614.1 - 8.6e-69 230.9 0.0 9.4e-69 230.7 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 AMD21614.1 - 8.9e-07 29.5 0.0 1.6e-06 28.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AMD21614.1 - 1.4e-06 28.8 0.0 3e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AMD21614.1 - 0.00024 21.4 0.0 0.00064 20.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 AMD21614.1 - 0.00029 21.4 0.0 0.00035 21.1 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 AMD21614.1 - 0.00039 20.6 0.0 0.002 18.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AMD21614.1 - 0.00055 20.2 0.1 0.0054 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AMD21614.1 - 0.00075 19.6 0.0 0.0013 18.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 AMD21614.1 - 0.0018 18.6 0.0 0.0029 18.0 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 AMD21614.1 - 0.002 17.9 0.4 0.0087 15.8 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 AMD21614.1 - 0.0042 17.5 0.1 0.023 15.1 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 AMD21614.1 - 0.0066 16.2 0.7 0.02 14.6 0.1 2.0 2 1 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.20 AMD21614.1 - 0.0079 15.3 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 AMD21614.1 - 0.0082 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase Rad17 PF03215.15 AMD21614.1 - 0.013 15.5 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 AMD21614.1 - 0.024 14.3 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 AMD21614.1 - 0.027 14.5 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 AMD21614.1 - 0.032 14.0 0.1 0.086 12.6 0.1 1.6 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 AMD21614.1 - 0.035 14.0 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 AMD21614.1 - 0.043 13.3 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 AMD21614.1 - 0.047 14.2 0.6 0.063 13.8 0.5 1.6 1 1 0 1 1 1 0 AAA domain dNK PF01712.19 AMD21614.1 - 0.079 12.8 0.1 0.23 11.3 0.0 1.8 2 0 0 2 2 2 0 Deoxynucleoside kinase Adeno_IVa2 PF02456.15 AMD21614.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Cytidylate_kin PF02224.18 AMD21614.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase cobW PF02492.19 AMD21614.1 - 0.12 11.9 0.1 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 AMD21614.1 - 0.14 12.1 0.1 0.25 11.3 0.0 1.5 2 0 0 2 2 1 0 NTPase HIG_1_N PF04588.13 AMD21615.1 - 4.1e-17 62.2 0.4 5.8e-17 61.6 0.4 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region HemX PF04375.14 AMD21615.1 - 0.0035 16.7 4.8 0.005 16.2 4.8 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase UPF0242 PF06785.11 AMD21615.1 - 0.008 16.3 6.3 0.011 15.9 6.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus MscS_porin PF12795.7 AMD21615.1 - 0.014 14.9 12.3 0.019 14.5 12.3 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain AAA_23 PF13476.6 AMD21615.1 - 0.11 13.0 7.3 0.11 13.0 7.3 1.2 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 AMD21615.1 - 0.33 9.6 8.5 0.42 9.2 8.5 1.1 1 0 0 1 1 1 0 AAA domain PEARLI-4 PF05278.12 AMD21615.1 - 0.77 9.3 11.4 1.1 8.8 11.4 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) APG6_N PF17675.1 AMD21615.1 - 0.77 10.3 15.0 1.2 9.7 15.0 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 AMD21615.1 - 3.2 6.6 16.4 1.5 7.6 12.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 AMD21615.1 - 6.5 5.7 10.3 8.6 5.3 10.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ubiquitin PF00240.23 AMD21616.1 - 0.00052 19.7 0.0 0.0013 18.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family AhpC-TSA PF00578.21 AMD21617.1 - 8.2e-34 116.2 0.0 1.4e-33 115.5 0.0 1.4 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 AMD21617.1 - 8.3e-18 64.5 0.3 1.3e-17 63.9 0.0 1.4 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 AMD21617.1 - 1.1e-08 34.8 0.1 2e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Lipocalin_2 PF08212.12 AMD21617.1 - 0.021 14.7 0.0 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipocalin-like domain SCO1-SenC PF02630.14 AMD21617.1 - 0.051 13.5 0.1 0.082 12.8 0.1 1.2 1 0 0 1 1 1 0 SCO1/SenC Homeodomain PF00046.29 AMD21618.1 - 6.6e-18 64.3 8.3 1.3e-17 63.3 8.3 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AMD21618.1 - 0.00088 19.1 0.5 0.00088 19.1 0.5 2.4 2 0 0 2 2 2 1 Homeobox KN domain Ribosomal_S13 PF00416.22 AMD21619.1 - 3.1e-57 192.5 2.5 3.6e-57 192.3 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 AMD21619.1 - 0.0008 18.3 0.0 0.0011 17.8 0.0 1.3 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) FTA4 PF13093.6 AMD21619.1 - 0.035 14.0 0.1 0.045 13.7 0.1 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Ribosomal_L4 PF00573.22 AMD21620.1 - 4.2e-51 173.4 0.0 5.4e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family FACT-Spt16_Nlob PF14826.6 AMD21620.1 - 0.16 11.7 0.1 0.25 11.1 0.1 1.2 1 0 0 1 1 1 0 FACT complex subunit SPT16 N-terminal lobe domain U3_assoc_6 PF08640.11 AMD21621.1 - 1.8e-31 108.0 7.6 3.1e-30 104.1 2.2 3.1 2 1 0 2 2 2 2 U3 small nucleolar RNA-associated protein 6 Suf PF05843.14 AMD21621.1 - 0.0024 17.9 9.0 0.045 13.7 6.9 3.7 1 1 0 1 1 1 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 AMD21621.1 - 0.037 14.8 0.0 9.4 7.4 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 AMD21621.1 - 0.06 13.0 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 TPR repeat ZZ PF00569.17 AMD21622.1 - 1.3e-16 60.2 8.2 2.1e-16 59.4 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.17 AMD21622.1 - 1.4e-10 41.3 2.2 6.5e-09 36.0 0.0 3.3 3 1 0 3 3 3 1 SWIRM domain Myb_DNA-binding PF00249.31 AMD21622.1 - 3.7e-08 33.4 0.2 2e-07 31.1 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD21622.1 - 8.1e-05 22.8 0.4 0.00081 19.6 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Ribosomal_S17e PF00833.18 AMD21623.1 - 5.9e-56 187.6 0.5 7e-56 187.4 0.5 1.1 1 0 0 1 1 1 1 Ribosomal S17 ECM11 PF15463.6 AMD21624.1 - 7.2e-19 68.7 2.2 7.2e-19 68.7 2.2 1.9 2 0 0 2 2 2 1 Extracellular mutant protein 11 AAA_27 PF13514.6 AMD21624.1 - 0.052 13.1 0.4 0.087 12.4 0.4 1.3 1 0 0 1 1 1 0 AAA domain DUF676 PF05057.14 AMD21625.1 - 5.3e-42 143.8 0.0 8.6e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 AMD21625.1 - 0.00029 20.7 0.0 0.00067 19.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.11 AMD21625.1 - 0.0053 16.1 0.0 0.0092 15.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.13 AMD21625.1 - 0.041 13.6 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 AMD21625.1 - 0.053 14.1 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD21625.1 - 0.095 12.0 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Med13_N PF11597.8 AMD21626.1 - 6.6e-68 229.4 1.6 1.2e-67 228.5 1.6 1.4 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal Med13_C PF06333.12 AMD21626.1 - 3.8e-27 95.4 5.5 4.2e-18 65.7 0.9 2.8 2 1 1 3 3 3 2 Mediator complex subunit 13 C-terminal domain Nse5 PF08691.10 AMD21627.1 - 1.1e-99 334.4 2.6 1.4e-99 334.1 2.6 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Pribosyltran PF00156.27 AMD21628.1 - 1.1e-15 57.5 0.0 1.4e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AMD21628.1 - 0.013 15.0 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase DOT1 PF08123.13 AMD21629.1 - 7.8e-86 286.8 0.0 1.2e-85 286.2 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 UDG PF03167.19 AMD21630.1 - 1.5e-20 73.8 0.0 2.9e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily LRS4 PF10422.9 AMD21632.1 - 1.1e-23 84.1 29.9 7.4e-23 81.4 29.9 2.3 1 1 0 1 1 1 1 Monopolin complex subunit LRS4 CARD PF00619.21 AMD21632.1 - 0.055 13.5 4.1 0.14 12.2 3.3 2.2 2 0 0 2 2 2 0 Caspase recruitment domain TetR_C_37 PF18665.1 AMD21632.1 - 0.17 12.5 3.8 1.1 9.9 3.8 2.3 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TfuA PF07812.12 AMD21632.1 - 0.17 11.6 3.2 0.38 10.5 0.5 2.1 2 0 0 2 2 2 0 TfuA-like protein DUF1974 PF09317.11 AMD21632.1 - 0.27 10.8 7.5 0.17 11.4 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) OST3_OST6 PF04756.13 AMD21633.1 - 3.8e-63 213.6 12.1 4.9e-63 213.2 12.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 AMD21633.1 - 3.9e-06 26.8 0.1 7.3e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin EamA PF00892.20 AMD21634.1 - 9.1e-13 48.6 41.3 2.9e-06 27.5 5.6 3.1 3 0 0 3 3 3 3 EamA-like transporter family DUF3955 PF13127.6 AMD21634.1 - 0.0033 17.2 1.3 0.0033 17.2 1.3 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF3955) Phage_holin_3_2 PF04550.12 AMD21634.1 - 0.082 13.5 2.1 6.1 7.5 0.3 2.9 2 0 0 2 2 2 0 Phage holin family 2 Phage_holin_2_4 PF16082.5 AMD21634.1 - 0.082 12.6 3.8 2.8 7.8 0.5 2.7 1 1 1 2 2 2 0 Bacteriophage holin family, superfamily II-like PIG-P PF08510.12 AMD21636.1 - 3.2e-31 107.8 1.3 4.4e-31 107.3 1.3 1.2 1 0 0 1 1 1 1 PIG-P DUF2710 PF10921.8 AMD21636.1 - 0.061 13.7 0.0 0.092 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2710) Metallophos PF00149.28 AMD21637.1 - 1.1e-35 124.1 0.1 1.7e-35 123.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AMD21637.1 - 3e-19 69.2 0.5 5.9e-19 68.3 0.5 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain LCM PF04072.14 AMD21638.1 - 4.7e-21 75.6 0.1 8.1e-21 74.8 0.1 1.5 2 0 0 2 2 2 1 Leucine carboxyl methyltransferase TAFII28 PF04719.14 AMD21639.1 - 3.7e-26 91.0 1.4 2.5e-23 82.0 0.4 2.7 3 0 0 3 3 3 2 hTAFII28-like protein conserved region Fungal_lectin_2 PF18647.1 AMD21639.1 - 0.0022 18.4 0.8 0.079 13.4 0.1 2.4 2 0 0 2 2 2 1 Alpha-galactosyl-binding fungal lectin PIG-S PF10510.9 AMD21640.1 - 1.4e-123 413.5 6.8 1.7e-123 413.2 6.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Methyltransf_11 PF08241.12 AMD21641.1 - 1.8e-10 41.3 0.0 3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD21641.1 - 2e-08 34.8 0.0 3.8e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD21641.1 - 1.2e-05 25.1 0.0 1.8e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD21641.1 - 3e-05 23.9 0.1 8.2e-05 22.5 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD21641.1 - 3.6e-05 24.4 0.0 8.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain UBA_4 PF14555.6 AMD21642.1 - 6.4e-12 45.1 0.0 1.3e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 AMD21642.1 - 1.1e-09 38.3 0.0 1.3e-07 31.7 0.0 3.3 2 1 0 2 2 2 1 UBX domain DUF2220 PF09983.9 AMD21642.1 - 2.1 7.7 6.3 3.8 6.8 6.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) RRM_1 PF00076.22 AMD21643.1 - 1.7e-30 104.6 0.6 4.6e-18 64.8 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AMD21643.1 - 7e-05 22.4 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 AMD21643.1 - 0.015 15.3 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain RRM_7 PF16367.5 AMD21643.1 - 0.016 15.3 0.1 0.17 12.0 0.1 2.1 1 1 0 1 1 1 0 RNA recognition motif Limkain-b1 PF11608.8 AMD21643.1 - 0.024 14.7 0.0 1.6 8.9 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 M16C_assoc PF08367.11 AMD21644.1 - 3.9e-72 242.4 0.4 3.9e-72 242.4 0.4 1.6 2 0 0 2 2 2 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 AMD21644.1 - 9.6e-27 94.2 0.1 5.9e-17 62.3 0.0 3.4 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AMD21644.1 - 5e-07 29.8 0.5 7.1e-06 26.1 0.0 3.0 3 1 0 3 3 3 1 Insulinase (Peptidase family M16) AAA_23 PF13476.6 AMD21644.1 - 0.37 11.3 7.1 0.09 13.3 2.4 2.3 2 0 0 2 2 2 0 AAA domain EMP24_GP25L PF01105.24 AMD21645.1 - 2.7e-39 135.0 0.0 3e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 AMD21645.1 - 0.013 13.7 0.4 0.015 13.5 0.4 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA COX2-transmemb PF09125.10 AMD21645.1 - 0.046 13.5 0.2 0.1 12.4 0.2 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane Takusan PF04822.13 AMD21645.1 - 0.049 13.5 1.3 0.078 12.9 1.3 1.3 1 0 0 1 1 1 0 Takusan DASH_Dad2 PF08654.10 AMD21645.1 - 0.051 14.0 0.1 0.075 13.5 0.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad2 Rad33 PF08730.10 AMD21646.1 - 2.2e-16 60.3 2.4 5.2e-08 33.0 0.2 2.1 1 1 1 2 2 2 2 Rad33 Spt5-NGN PF03439.13 AMD21647.1 - 1.1e-21 76.5 0.0 2.6e-21 75.3 0.0 1.7 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 AMD21647.1 - 9.1e-21 74.7 18.0 9.1e-21 74.7 18.0 3.6 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 AMD21647.1 - 1.4e-13 50.3 7.7 0.002 18.0 0.0 4.7 4 0 0 4 4 4 4 KOW motif DUF3912 PF13051.6 AMD21647.1 - 0.032 14.5 1.0 5.4 7.3 0.1 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3912) Leucyl-specific PF14795.6 AMD21647.1 - 0.18 11.9 1.8 4.7 7.3 0.0 2.9 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain Ribosomal_L33 PF00471.20 AMD21648.1 - 0.0039 17.6 0.4 0.011 16.1 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L33 eIF3g PF12353.8 AMD21649.1 - 1.4e-38 132.1 0.3 2.3e-38 131.4 0.3 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 AMD21649.1 - 6.1e-12 45.2 0.0 1.1e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_2 PF13696.6 AMD21649.1 - 0.0013 18.5 1.4 0.0022 17.8 1.4 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 AMD21649.1 - 0.0067 16.5 0.8 0.011 15.8 0.8 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-Mss51 PF13824.6 AMD21649.1 - 0.46 10.6 1.6 0.8 9.9 0.3 2.0 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Abhydrolase_3 PF07859.13 AMD21650.1 - 7.1e-08 32.6 0.0 7.9e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 AMD21650.1 - 8.9e-05 21.5 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 AMD21650.1 - 0.00053 19.5 0.1 0.0016 17.9 0.1 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family LIDHydrolase PF10230.9 AMD21650.1 - 0.0019 17.8 0.1 0.0038 16.8 0.1 1.5 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 AMD21650.1 - 0.037 13.7 0.0 0.09 12.4 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 AMD21650.1 - 0.048 13.5 0.3 0.45 10.4 0.1 2.5 2 1 0 2 2 2 0 Lipase (class 3) Hydrolase_4 PF12146.8 AMD21650.1 - 0.064 12.5 0.0 0.45 9.7 0.0 1.9 1 1 0 2 2 2 0 Serine aminopeptidase, S33 DUF900 PF05990.12 AMD21650.1 - 0.084 12.4 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Rpn9_C PF18261.1 AMD21651.1 - 7.9e-14 50.9 1.6 1.8e-13 49.8 1.6 1.7 1 0 0 1 1 1 1 Rpn9 C-terminal helix PCI PF01399.27 AMD21651.1 - 1.5e-10 41.5 0.6 4.1e-10 40.1 0.2 2.0 2 0 0 2 2 2 1 PCI domain PX PF00787.24 AMD21652.1 - 4.4e-15 55.6 1.1 1.1e-14 54.4 0.0 2.2 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 AMD21652.1 - 0.0085 15.7 6.8 0.0085 15.7 6.8 2.1 2 0 0 2 2 2 1 Vps5 C terminal like PI3K_P85_iSH2 PF16454.5 AMD21652.1 - 0.015 14.9 12.8 0.57 9.8 6.4 3.0 2 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF489 PF04356.12 AMD21652.1 - 0.16 11.9 5.3 12 5.8 0.9 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF489) PFK PF00365.20 AMD21652.1 - 0.19 11.0 0.4 0.36 10.1 0.0 1.6 2 0 0 2 2 2 0 Phosphofructokinase DUF99 PF01949.16 AMD21652.1 - 0.22 10.9 0.5 34 3.8 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function DUF99 BLOC1_2 PF10046.9 AMD21652.1 - 2.3 8.6 11.5 16 5.9 0.1 3.5 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N PF02403.22 AMD21652.1 - 4.9 7.4 9.0 6.2 7.1 0.1 3.0 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain FtsX_ECD PF18075.1 AMD21652.1 - 5.5 7.7 8.8 13 6.5 0.1 3.8 3 1 1 4 4 4 0 FtsX extracellular domain Dynein_light PF01221.18 AMD21653.1 - 2e-32 111.3 0.0 2.2e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Kinesin PF00225.23 AMD21654.1 - 1.9e-99 332.8 2.6 2.8e-99 332.2 2.6 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AMD21654.1 - 4.3e-23 81.9 0.3 4.3e-23 81.9 0.3 1.8 2 0 0 2 2 2 1 Microtubule binding EzrA PF06160.12 AMD21654.1 - 5.5e-05 21.5 2.9 8.9e-05 20.9 2.9 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4164 PF13747.6 AMD21654.1 - 0.018 15.3 2.5 0.37 11.1 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF5420 PF17457.2 AMD21654.1 - 0.039 13.8 1.6 0.057 13.3 0.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5420) AAA_7 PF12775.7 AMD21654.1 - 0.096 12.2 0.6 0.84 9.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region YfkD PF14167.6 AMD21654.1 - 0.13 11.4 1.0 0.19 10.9 0.2 1.6 2 0 0 2 2 2 0 YfkD-like protein Carbpep_Y_N PF05388.11 AMD21654.1 - 0.19 12.2 1.5 0.37 11.4 1.1 1.7 1 1 0 1 1 1 0 Carboxypeptidase Y pro-peptide YabA PF06156.13 AMD21654.1 - 0.26 11.9 5.2 4.9 7.8 0.0 3.2 3 0 0 3 3 3 0 Initiation control protein YabA CCDC-167 PF15188.6 AMD21654.1 - 0.71 10.2 5.6 2 8.8 3.4 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 AMPKBI PF04739.15 AMD21655.1 - 3.8e-21 75.1 2.9 3.8e-21 75.1 0.5 2.3 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 AMD21655.1 - 3.8e-08 33.4 0.0 1e-07 32.1 0.0 1.7 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase bZIP_1 PF00170.21 AMD21656.1 - 2e-05 24.6 12.7 4.7e-05 23.4 12.7 1.6 1 0 0 1 1 1 1 bZIP transcription factor Androgen_recep PF02166.16 AMD21656.1 - 0.022 13.6 1.2 0.026 13.4 1.2 1.2 1 0 0 1 1 1 0 Androgen receptor DUF4643 PF15485.6 AMD21656.1 - 0.049 13.5 5.2 0.087 12.7 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4643) Spt20 PF12090.8 AMD21656.1 - 0.056 13.1 4.3 0.093 12.3 4.3 1.3 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 AMD21656.1 - 1 8.4 7.7 0.031 13.5 1.9 1.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal DUF2967 PF11179.8 AMD21656.1 - 5.9 4.9 5.7 2.5 6.1 2.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2967) DUF3682 PF12446.8 AMD21656.1 - 6.4 7.3 12.8 14 6.1 8.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) bZIP_Maf PF03131.17 AMD21656.1 - 7 7.3 22.5 0.68 10.5 11.1 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor Med21 PF11221.8 AMD21656.1 - 8.6 6.6 14.2 2 8.6 4.4 2.8 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Sterol_MT_C PF08498.10 AMD21657.1 - 7.3e-26 90.3 0.7 1.2e-25 89.6 0.7 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 AMD21657.1 - 6e-20 71.7 0.0 1.1e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD21657.1 - 2.3e-17 63.5 0.0 4.7e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD21657.1 - 7.3e-15 55.1 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD21657.1 - 4.3e-11 42.9 0.0 6.9e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AMD21657.1 - 6.9e-11 41.9 0.0 1e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 AMD21657.1 - 1e-10 41.4 0.1 1.4e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 AMD21657.1 - 1.9e-09 38.2 0.0 3.6e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 AMD21657.1 - 0.00035 20.2 0.6 0.00074 19.1 0.6 1.5 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MetW PF07021.12 AMD21657.1 - 0.092 12.3 0.0 0.25 10.9 0.0 1.7 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW DOT1 PF08123.13 AMD21657.1 - 0.095 12.2 0.0 0.22 11.1 0.0 1.5 1 1 0 1 1 1 0 Histone methylation protein DOT1 RrnaAD PF00398.20 AMD21657.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Sugar_tr PF00083.24 AMD21658.1 - 8.3e-31 107.3 30.3 3.4e-20 72.4 9.5 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 AMD21658.1 - 3e-19 69.2 40.4 3.3e-11 42.7 20.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CYSTM PF12734.7 AMD21660.1 - 0.023 15.0 19.5 0.069 13.5 19.5 1.9 1 1 0 1 1 1 0 Cysteine-rich TM module stress tolerance PIP5K PF01504.18 AMD21661.1 - 4.1e-96 321.4 0.2 7.8e-96 320.5 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase eIF-5a PF01287.20 AMD21662.1 - 1e-29 102.4 0.5 1.5e-29 101.9 0.5 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 AMD21662.1 - 0.003 17.5 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain MCM PF00493.23 AMD21663.1 - 2e-95 318.2 0.5 2.9e-95 317.6 0.5 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AMD21663.1 - 1.1e-31 109.2 0.0 2.6e-31 108.1 0.0 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AMD21663.1 - 1e-24 86.7 2.0 2.1e-24 85.7 2.0 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 AMD21663.1 - 2.4e-07 30.3 0.0 2.1e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 AMD21663.1 - 4.7e-07 30.3 0.0 4.1e-06 27.3 0.0 2.5 2 0 0 2 2 2 1 MCM N-terminal domain AAA_3 PF07726.11 AMD21663.1 - 0.0052 16.6 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AMD21663.1 - 0.0063 16.2 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain Hydrolase PF00702.26 AMD21664.1 - 1.6e-18 67.7 0.0 2.7e-11 44.1 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 AMD21664.1 - 1.2e-17 64.0 0.1 2.5e-17 63.0 0.1 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 AMD21664.1 - 0.00041 20.4 0.0 0.00094 19.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 AMD21664.1 - 0.0059 16.4 0.1 0.025 14.3 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3021 PF11457.8 AMD21664.1 - 0.024 15.0 0.9 0.091 13.1 0.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF3744 PF12558.8 AMD21664.1 - 0.091 13.5 0.3 0.4 11.5 0.1 2.2 2 0 0 2 2 2 0 ATP-binding cassette cobalt transporter S6PP PF05116.13 AMD21664.1 - 0.098 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase CDT1_C PF16679.5 AMD21665.1 - 2.9e-06 27.6 0.4 1e-05 25.9 0.4 1.9 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain HSP70 PF00012.20 AMD21666.1 - 1.2e-266 885.8 13.6 1.3e-266 885.6 13.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AMD21666.1 - 1.7e-15 56.7 2.9 1.6e-13 50.2 0.8 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AMD21666.1 - 0.0011 18.7 0.0 0.0033 17.2 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 AMD21666.1 - 0.012 16.0 9.4 0.88 10.0 0.5 4.3 3 2 0 3 3 3 0 Cell division protein FtsA Syntaxin_2 PF14523.6 AMD21666.1 - 0.37 11.2 8.1 2.7 8.4 1.1 2.7 1 1 1 2 2 2 0 Syntaxin-like protein Vps55 PF04133.14 AMD21667.1 - 5.7e-38 129.5 9.7 6.6e-38 129.3 9.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 7tm_6 PF02949.20 AMD21667.1 - 0.0025 16.9 0.7 0.0041 16.2 0.7 1.3 1 0 0 1 1 1 1 7tm Odorant receptor DUF1700 PF08006.11 AMD21667.1 - 2 7.9 7.5 3.9 7.0 7.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1700) YPEB PF14620.6 AMD21668.1 - 0.0019 17.6 4.8 0.0036 16.7 4.7 1.4 1 1 0 1 1 1 1 YpeB sporulation Sec20 PF03908.13 AMD21668.1 - 0.16 11.9 2.7 0.19 11.7 0.4 2.3 2 0 0 2 2 2 0 Sec20 Pkinase PF00069.25 AMD21669.1 - 2.4e-66 223.8 0.0 3.2e-66 223.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21669.1 - 1.8e-30 106.1 0.0 2.8e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD21669.1 - 3.5e-08 33.1 0.0 6.9e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AMD21669.1 - 0.00053 19.0 0.0 0.00099 18.2 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AMD21669.1 - 0.0014 18.6 0.0 0.0072 16.3 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 AMD21669.1 - 0.0021 17.5 0.0 0.0039 16.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 AMD21669.1 - 0.082 12.5 0.2 0.56 9.8 0.0 2.2 2 0 0 2 2 2 0 RIO1 family DAO PF01266.24 AMD21670.1 - 4e-79 266.8 0.0 4.8e-79 266.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AMD21670.1 - 9.7e-07 28.9 0.1 3.1e-06 27.3 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 AMD21670.1 - 0.00013 21.3 0.1 0.00023 20.5 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 AMD21670.1 - 0.00083 18.7 0.0 0.021 14.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 AMD21670.1 - 0.0023 18.2 0.1 0.0054 17.0 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 AMD21670.1 - 0.0084 16.1 0.1 0.02 14.9 0.1 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 AMD21670.1 - 0.02 13.7 0.1 0.03 13.2 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase MCRA PF06100.11 AMD21670.1 - 0.022 13.6 0.2 0.031 13.1 0.2 1.2 1 0 0 1 1 1 0 MCRA family Pyr_redox PF00070.27 AMD21670.1 - 0.035 14.7 0.1 0.093 13.3 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Syntaxin-6_N PF09177.11 AMD21671.1 - 5e-06 27.0 6.3 2e-05 25.1 1.3 3.2 2 2 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 AMD21671.1 - 6.9e-06 26.0 0.6 3.3e-05 23.8 0.2 2.2 2 0 0 2 2 2 1 SNARE domain FlxA PF14282.6 AMD21671.1 - 0.0082 16.1 4.6 0.0082 16.1 4.6 2.5 1 1 0 2 2 2 1 FlxA-like protein GAS PF13851.6 AMD21671.1 - 0.012 14.9 2.3 0.017 14.4 2.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding KxDL PF10241.9 AMD21671.1 - 0.013 15.7 9.0 0.048 14.0 2.0 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein VasL PF12486.8 AMD21671.1 - 0.014 15.3 1.1 0.076 12.9 0.7 2.0 2 0 0 2 2 2 0 Type VI secretion system, EvfB, or VasL SKA1 PF07160.12 AMD21671.1 - 0.02 14.7 3.4 1.5 8.6 0.7 2.4 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 TPD52 PF04201.15 AMD21671.1 - 0.037 13.7 2.0 0.47 10.1 2.0 2.2 1 1 0 1 1 1 0 Tumour protein D52 family Sec20 PF03908.13 AMD21671.1 - 0.056 13.4 3.5 0.087 12.8 0.4 2.6 2 1 1 3 3 3 0 Sec20 Mto2_bdg PF12808.7 AMD21671.1 - 0.056 13.8 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region MPS2 PF17060.5 AMD21671.1 - 0.059 12.6 1.4 0.17 11.1 0.7 1.9 1 1 1 2 2 2 0 Monopolar spindle protein 2 Filament PF00038.21 AMD21671.1 - 0.13 11.9 6.8 0.22 11.1 4.7 2.2 1 1 1 2 2 2 0 Intermediate filament protein DUF1664 PF07889.12 AMD21671.1 - 0.45 10.6 4.4 8.2 6.5 0.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1640 PF07798.11 AMD21671.1 - 0.82 9.7 7.8 4.7 7.2 1.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Fib_alpha PF08702.10 AMD21671.1 - 1.2 9.3 7.5 8.9 6.5 3.4 2.7 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family YabA PF06156.13 AMD21671.1 - 1.9 9.2 5.2 2.7e+02 2.3 5.2 2.9 1 1 0 1 1 1 0 Initiation control protein YabA Csm1_N PF18504.1 AMD21671.1 - 1.9 8.9 7.3 0.45 10.9 0.7 2.9 2 1 2 4 4 4 0 Csm1 N-terminal domain SlyX PF04102.12 AMD21671.1 - 3.7 8.2 12.9 1.1 9.9 2.1 3.4 1 1 1 2 2 2 0 SlyX MHC2-interact PF09307.10 AMD21671.1 - 3.9 7.5 7.8 18 5.4 0.4 2.9 2 1 1 3 3 3 0 CLIP, MHC2 interacting Dpy-30 PF05186.13 AMD21672.1 - 9.9e-14 50.8 0.0 1.3e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Mito_carr PF00153.27 AMD21673.1 - 6.5e-11 42.0 0.0 0.0017 18.2 0.0 3.4 3 1 0 3 3 3 2 Mitochondrial carrier protein DUF1652 PF07865.11 AMD21674.1 - 0.49 10.3 3.7 2.8 7.8 0.3 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1652) DUF745 PF05335.13 AMD21674.1 - 0.55 9.9 12.7 0.12 12.1 5.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF745) TMF_TATA_bd PF12325.8 AMD21674.1 - 8.5 6.6 25.2 0.83 9.9 11.4 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 AMD21674.1 - 9.3 5.5 13.0 8.6 5.6 12.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_L27e PF01777.18 AMD21675.1 - 3.2e-36 123.5 6.6 4.8e-36 123.0 6.6 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 AMD21675.1 - 0.0035 17.2 1.4 0.0064 16.4 1.4 1.5 1 0 0 1 1 1 1 KOW motif Ndr PF03096.14 AMD21675.1 - 0.13 10.9 0.0 0.18 10.5 0.0 1.4 1 0 0 1 1 1 0 Ndr family tRNA-synt_2b PF00587.25 AMD21676.1 - 5.4e-21 75.4 0.0 1.1e-20 74.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AMD21676.1 - 1.7e-06 28.2 4.7 3.2e-06 27.3 4.7 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.14 AMD21676.1 - 0.0012 18.7 2.6 0.002 18.0 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF724) FmiP_Thoc5 PF09766.9 AMD21676.1 - 0.0014 17.9 3.6 0.0021 17.4 3.6 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 CREPT PF16566.5 AMD21676.1 - 0.003 17.7 2.6 0.0056 16.9 2.6 1.3 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour Atg14 PF10186.9 AMD21676.1 - 0.0031 16.6 2.6 0.0046 16.1 2.6 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 MscS_porin PF12795.7 AMD21676.1 - 0.0033 17.0 7.1 0.0053 16.3 7.1 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF3450 PF11932.8 AMD21676.1 - 0.0042 16.4 2.9 0.0068 15.7 2.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Raptor_N PF14538.6 AMD21676.1 - 0.0046 16.9 0.5 0.0099 15.8 0.0 1.8 2 0 0 2 2 1 1 Raptor N-terminal CASPase like domain EzrA PF06160.12 AMD21676.1 - 0.0049 15.1 4.9 0.007 14.6 4.9 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA COG5 PF10392.9 AMD21676.1 - 0.011 15.9 1.5 0.02 15.1 1.5 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 HemX PF04375.14 AMD21676.1 - 0.017 14.4 5.7 0.025 13.9 5.7 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Sec2p PF06428.11 AMD21676.1 - 0.017 15.1 4.2 0.017 15.1 4.2 1.9 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DUF812 PF05667.11 AMD21676.1 - 0.02 13.8 5.0 0.032 13.1 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Occludin_ELL PF07303.13 AMD21676.1 - 0.027 15.2 3.6 0.054 14.2 3.6 1.5 1 0 0 1 1 1 0 Occludin homology domain Spc7 PF08317.11 AMD21676.1 - 0.03 13.2 5.2 0.045 12.6 5.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FPP PF05911.11 AMD21676.1 - 0.036 12.3 5.7 0.047 11.9 5.7 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Golgin_A5 PF09787.9 AMD21676.1 - 0.083 12.3 6.3 0.15 11.5 6.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 rRNA_proc-arch PF13234.6 AMD21676.1 - 0.09 12.7 5.8 0.17 11.8 5.8 1.4 1 0 0 1 1 1 0 rRNA-processing arch domain ATG16 PF08614.11 AMD21676.1 - 0.11 12.7 7.8 0.18 12.0 7.8 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) FapA PF03961.13 AMD21676.1 - 0.13 10.8 3.2 0.19 10.3 3.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Tho2 PF11262.8 AMD21676.1 - 0.16 11.1 5.0 0.26 10.5 5.0 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Allexi_40kDa PF05549.11 AMD21676.1 - 0.22 11.0 1.6 0.39 10.2 1.2 1.6 2 0 0 2 2 2 0 Allexivirus 40kDa protein Muted PF14942.6 AMD21676.1 - 0.24 11.7 7.1 0.43 10.9 7.1 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Macoilin PF09726.9 AMD21676.1 - 0.32 9.5 5.9 0.46 9.0 5.9 1.1 1 0 0 1 1 1 0 Macoilin family TMPIT PF07851.13 AMD21676.1 - 0.34 10.1 3.5 0.53 9.5 3.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein AAA_23 PF13476.6 AMD21676.1 - 0.4 11.2 8.2 0.72 10.3 8.2 1.4 1 0 0 1 1 1 0 AAA domain DUF573 PF04504.14 AMD21676.1 - 0.6 10.8 5.1 0.45 11.2 2.7 2.0 2 0 0 2 2 1 0 Protein of unknown function, DUF573 APG6_N PF17675.1 AMD21676.1 - 0.7 10.4 10.1 0.037 14.6 4.2 1.8 3 0 0 3 3 1 0 Apg6 coiled-coil region DivIC PF04977.15 AMD21676.1 - 0.71 9.7 12.7 0.46 10.3 5.8 2.4 1 1 1 2 2 2 0 Septum formation initiator Mod_r PF07200.13 AMD21676.1 - 0.72 10.0 9.9 0.79 9.8 8.7 1.6 2 0 0 2 2 1 0 Modifier of rudimentary (Mod(r)) protein SKA2 PF16740.5 AMD21676.1 - 0.73 9.6 6.8 0.48 10.2 0.3 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 FAM76 PF16046.5 AMD21676.1 - 1.1 8.5 5.1 1.6 8.0 5.1 1.2 1 0 0 1 1 1 0 FAM76 protein MRPL52 PF18699.1 AMD21676.1 - 1.1 9.4 5.0 2.2 8.5 2.3 2.1 1 1 1 2 2 2 0 Mitoribosomal protein mL52 CLZ PF16526.5 AMD21676.1 - 1.2 9.6 6.8 2.4 8.6 1.1 2.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FliD_N PF02465.18 AMD21676.1 - 7.8 7.3 8.6 3.5e+02 2.0 8.6 2.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Metallophos_2 PF12850.7 AMD21677.1 - 1.3e-10 41.7 0.0 2.4e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Myc_N PF01056.18 AMD21677.1 - 1.3 8.8 6.4 1.9 8.3 6.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region YbgS PF13985.6 AMD21677.1 - 3.7 7.9 7.4 1.3 9.3 4.0 1.8 2 0 0 2 2 2 0 YbgS-like protein S-methyl_trans PF02574.16 AMD21678.1 - 5.9e-57 193.5 0.0 6.9e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Acetyltransf_1 PF00583.25 AMD21679.1 - 4.3e-11 43.1 0.0 6.1e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AMD21679.1 - 1.1e-06 28.6 0.1 1.4e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AMD21679.1 - 4.9e-05 23.7 0.0 9.1e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AMD21679.1 - 0.00052 19.9 0.0 0.00091 19.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 AMD21679.1 - 0.017 14.6 0.5 0.024 14.1 0.5 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase Viral_env_E26 PF11050.8 AMD21679.1 - 0.064 12.6 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 Virus envelope protein E26 TRAPP PF04051.16 AMD21680.1 - 3.7e-43 146.8 0.0 4.5e-43 146.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF3824 PF12868.7 AMD21681.1 - 1.2 9.8 10.6 0.076 13.7 3.6 2.1 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Carm_PH PF17888.1 AMD21682.1 - 0.14 12.5 1.2 0.31 11.4 0.1 1.9 2 0 0 2 2 2 0 Carmil pleckstrin homology domain Ribosomal_L23 PF00276.20 AMD21683.1 - 2e-10 40.9 0.0 4.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 RNA_pol_Rpb2_6 PF00562.28 AMD21684.1 - 6e-125 417.3 0.2 1e-124 416.6 0.1 1.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AMD21684.1 - 1.2e-68 230.6 0.1 2.1e-68 229.9 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AMD21684.1 - 1.9e-51 174.4 0.0 3.4e-51 173.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 AMD21684.1 - 3.9e-34 116.9 0.1 8.6e-34 115.8 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 AMD21684.1 - 1.8e-25 89.0 0.9 4.7e-25 87.7 0.9 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 AMD21684.1 - 3.3e-24 84.8 1.0 6.4e-24 83.9 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 AMD21684.1 - 7.2e-19 68.1 0.3 7.2e-19 68.1 0.3 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 MRNIP PF15749.5 AMD21684.1 - 0.089 13.5 0.1 0.17 12.6 0.1 1.4 1 0 0 1 1 1 0 MRN-interacting protein Ribosomal_L13 PF00572.18 AMD21685.1 - 1.6e-45 154.3 0.2 2e-45 154.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 SHS2_Rpb7-N PF03876.17 AMD21686.1 - 2.5e-17 63.0 0.0 4.2e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AMD21686.1 - 8.2e-13 48.5 0.0 1.2e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 AMD21686.1 - 0.00053 20.2 0.0 0.00089 19.5 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 DIT1_PvcA PF05141.12 AMD21687.1 - 4.2e-98 328.2 0.0 5.6e-98 327.8 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein p450 PF00067.22 AMD21688.1 - 3e-55 187.8 0.1 4e-55 187.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 ssDNA_DBD PF18333.1 AMD21688.1 - 0.073 13.2 0.5 0.19 11.8 0.5 1.7 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain RPA_interact_N PF14766.6 AMD21688.1 - 0.11 12.1 0.1 0.11 12.1 0.1 2.7 3 0 0 3 3 3 0 Replication protein A interacting N-terminal IU_nuc_hydro PF01156.19 AMD21689.1 - 1.3e-70 238.4 0.0 1.6e-70 238.1 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Utp12 PF04003.12 AMD21690.1 - 8.1e-22 77.6 3.3 1.4e-21 76.8 3.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 AMD21690.1 - 1.5e-06 28.4 0.1 0.0012 19.1 0.0 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain IceA2 PF05862.11 AMD21690.1 - 3e-05 23.8 0.6 8.6e-05 22.4 0.2 2.0 2 0 0 2 2 2 1 Helicobacter pylori IceA2 protein Candida_ALS_N PF11766.8 AMD21690.1 - 0.17 11.1 0.3 0.3 10.3 0.3 1.3 1 0 0 1 1 1 0 Cell-wall agglutinin N-terminal ligand-sugar binding CBFD_NFYB_HMF PF00808.23 AMD21691.1 - 3e-14 53.1 0.7 5.3e-14 52.3 0.7 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AMD21691.1 - 0.028 14.8 0.1 0.028 14.8 0.1 1.8 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 DUF2960 PF11173.8 AMD21691.1 - 0.071 13.6 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2960) IBN_N PF03810.19 AMD21692.1 - 1.2e-14 53.9 0.2 6e-14 51.7 0.2 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Urb2 PF10441.9 AMD21692.1 - 0.016 15.2 0.9 0.27 11.1 0.2 2.8 2 1 0 2 2 2 0 Urb2/Npa2 family DUF445 PF04286.12 AMD21692.1 - 0.061 13.1 3.1 0.23 11.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Vac14_Fab1_bd PF12755.7 AMD21692.1 - 0.27 11.8 5.9 0.15 12.7 0.4 3.4 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 AMD21692.1 - 0.36 11.0 2.1 3 8.0 0.3 3.4 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Glyco_transf_22 PF03901.17 AMD21693.1 - 2.2e-60 205.1 13.5 2.7e-60 204.7 13.5 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF2142 PF09913.9 AMD21693.1 - 4.5e-05 22.5 10.8 4.5e-05 22.5 10.8 1.7 1 1 0 1 1 1 1 Predicted membrane protein (DUF2142) AAA PF00004.29 AMD21694.1 - 3.6e-46 156.9 0.0 1e-45 155.4 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 AMD21694.1 - 2e-09 37.2 0.2 8.5e-09 35.2 0.0 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AMD21694.1 - 2.8e-08 34.1 0.0 5.5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AMD21694.1 - 1.3e-07 32.2 0.0 2.7e-05 24.6 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 AMD21694.1 - 2.6e-07 30.7 0.1 1.1e-06 28.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AMD21694.1 - 2.7e-05 24.5 0.7 0.0038 17.5 0.0 2.6 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 AMD21694.1 - 6.2e-05 22.3 0.0 0.00011 21.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 AMD21694.1 - 0.00023 20.9 0.0 0.00073 19.3 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 AMD21694.1 - 0.0008 19.4 0.2 0.0028 17.6 0.0 2.0 3 0 0 3 3 2 1 NTPase AAA_lid_3 PF17862.1 AMD21694.1 - 0.00092 19.0 0.1 0.0024 17.6 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_30 PF13604.6 AMD21694.1 - 0.0013 18.4 0.0 0.004 16.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 AMD21694.1 - 0.0015 18.5 0.0 0.0028 17.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 AMD21694.1 - 0.0019 18.6 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 AMD21694.1 - 0.0022 18.6 0.0 0.0078 16.8 0.0 2.0 3 0 0 3 3 1 1 AAA domain AAA_7 PF12775.7 AMD21694.1 - 0.0027 17.2 0.0 0.022 14.3 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region TIP49 PF06068.13 AMD21694.1 - 0.003 16.8 0.0 0.005 16.1 0.0 1.4 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 AMD21694.1 - 0.0032 17.2 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 AMD21694.1 - 0.0033 17.4 0.0 0.0076 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AMD21694.1 - 0.0034 17.3 0.0 0.011 15.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 AMD21694.1 - 0.0051 16.2 0.0 0.3 10.5 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein Sigma54_activat PF00158.26 AMD21694.1 - 0.006 16.3 0.0 0.16 11.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.6 AMD21694.1 - 0.0069 16.6 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AMD21694.1 - 0.0074 15.7 0.1 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AMD21694.1 - 0.016 15.5 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AMD21694.1 - 0.017 15.0 0.2 0.12 12.3 0.0 2.2 1 1 1 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 AMD21694.1 - 0.025 14.3 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 AMD21694.1 - 0.027 14.4 0.1 0.41 10.5 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 AMD21694.1 - 0.037 13.8 0.0 0.076 12.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 AMD21694.1 - 0.074 11.9 0.0 0.15 10.9 0.0 1.6 2 0 0 2 2 2 0 AFG1-like ATPase AAA_25 PF13481.6 AMD21694.1 - 0.088 12.4 0.4 0.48 10.0 0.1 2.0 1 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 AMD21694.1 - 0.12 12.7 0.1 0.35 11.2 0.0 1.7 2 0 0 2 2 1 0 AAA domain DnaB_C PF03796.15 AMD21694.1 - 0.19 11.0 1.0 4.4 6.6 0.1 2.7 3 0 0 3 3 3 0 DnaB-like helicase C terminal domain She9_MDM33 PF05546.11 AMD21695.1 - 1.2e-80 270.0 11.5 1.2e-80 270.0 11.5 2.1 2 0 0 2 2 2 1 She9 / Mdm33 family PsbH PF00737.20 AMD21695.1 - 0.018 14.7 0.5 0.05 13.3 0.5 1.7 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein DUF4850 PF16142.5 AMD21695.1 - 0.092 12.2 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4850) TMF_DNA_bd PF12329.8 AMD21695.1 - 0.14 12.1 0.0 0.14 12.1 0.0 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding SH3-WW_linker PF16618.5 AMD21695.1 - 0.84 10.1 8.8 0.62 10.5 0.1 2.9 2 1 1 3 3 3 0 Linker region between SH3 and WW domains on ARHGAP12 GP41 PF00517.17 AMD21695.1 - 2.5 7.9 9.0 0.57 10.1 0.8 3.0 3 1 0 3 3 3 0 Retroviral envelope protein G-patch_2 PF12656.7 AMD21696.1 - 4.3e-18 65.1 1.7 5.4e-18 64.8 0.1 2.0 2 0 0 2 2 2 1 G-patch domain Pur_DNA_glyco PF02245.16 AMD21696.1 - 0.086 12.3 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 Methylpurine-DNA glycosylase (MPG) MDM31_MDM32 PF08118.11 AMD21697.1 - 8.2e-95 318.4 12.4 2.4e-44 151.9 0.6 4.1 2 1 2 4 4 4 4 Yeast mitochondrial distribution and morphology (MDM) proteins Orn_DAP_Arg_deC PF00278.22 AMD21697.1 - 0.19 12.0 0.0 0.42 10.9 0.0 1.6 1 1 0 1 1 1 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain KH_8 PF17903.1 AMD21698.1 - 0.0008 19.5 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 AMD21698.1 - 0.064 13.1 0.3 0.14 12.0 0.3 1.6 1 0 0 1 1 1 0 KH domain KH_4 PF13083.6 AMD21698.1 - 0.14 12.0 0.3 27 4.7 0.0 2.8 3 0 0 3 3 3 0 KH domain AAA PF00004.29 AMD21699.1 - 0.022 15.2 0.5 0.093 13.2 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 AMD21699.1 - 0.056 13.2 0.3 0.056 13.2 0.3 2.8 4 0 0 4 4 4 0 DNA polymerase III, delta subunit Phage_holin_6_1 PF09682.10 AMD21699.1 - 2 8.9 5.0 2.1 8.8 0.0 2.9 3 0 0 3 3 3 0 Bacteriophage holin of superfamily 6 (Holin_LLH) TFIID-18kDa PF02269.16 AMD21700.1 - 1.6e-35 121.0 0.6 3.1e-35 120.0 0.1 1.7 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TPK_catalytic PF04263.16 AMD21701.1 - 1.1e-29 102.8 0.0 2.3e-29 101.9 0.0 1.5 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 AMD21701.1 - 8.6e-14 51.0 0.3 1.6e-13 50.1 0.3 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain DUF1140 PF06600.11 AMD21702.1 - 0.055 13.9 0.2 0.089 13.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1140) KleE PF17394.2 AMD21702.1 - 0.083 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein Clat_adaptor_s PF01217.20 AMD21703.1 - 2.3e-53 180.0 0.7 2.6e-53 179.8 0.7 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TP_methylase PF00590.20 AMD21704.1 - 7.2e-26 91.5 0.0 1e-25 90.9 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Mpv17_PMP22 PF04117.12 AMD21707.1 - 9e-26 89.9 3.3 9e-26 89.9 3.3 2.2 2 0 0 2 2 2 1 Mpv17 / PMP22 family ABC1 PF03109.16 AMD21708.1 - 1.1e-31 109.4 0.0 2.9e-31 108.1 0.0 1.7 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 AMD21708.1 - 0.00011 21.9 0.1 0.00054 19.6 0.0 2.2 3 0 0 3 3 3 1 RIO1 family m04gp34like PF12216.8 AMD21708.1 - 0.91 9.0 6.1 4.6 6.7 0.4 2.9 3 0 0 3 3 3 0 Immune evasion protein V_ATPase_I PF01496.19 AMD21709.1 - 0.036 12.0 5.9 0.037 11.9 5.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_1 PF00170.21 AMD21709.1 - 0.044 13.9 17.9 0.7 10.0 4.6 3.4 1 1 2 3 3 3 0 bZIP transcription factor hDGE_amylase PF14701.6 AMD21709.1 - 0.093 11.8 3.6 0.11 11.6 3.6 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain G-gamma PF00631.22 AMD21709.1 - 0.18 11.9 0.2 0.18 11.9 0.2 2.6 2 1 0 2 2 2 0 GGL domain Exonuc_VII_L PF02601.15 AMD21709.1 - 0.31 10.6 4.1 0.34 10.4 4.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit KELK PF15796.5 AMD21709.1 - 0.38 11.2 14.1 2.4 8.7 7.3 2.3 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF3450 PF11932.8 AMD21709.1 - 2.4 7.4 18.7 3.3 6.9 5.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 AMD21709.1 - 2.5 8.6 21.6 6.4 7.3 21.6 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region Fungal_trans PF04082.18 AMD21710.1 - 1.6e-08 33.9 1.1 5e-08 32.3 1.1 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD21710.1 - 2e-07 31.0 8.6 4e-07 30.0 8.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ferric_reduct PF01794.19 AMD21711.1 - 3.4e-14 53.0 10.7 3.4e-14 53.0 10.7 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AMD21711.1 - 8e-14 51.6 0.0 1.9e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 AMD21711.1 - 6.1e-09 36.2 0.0 1.7e-08 34.8 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Vezatin PF12632.7 AMD21712.1 - 0.00016 21.2 6.6 0.00016 21.2 6.6 2.1 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes UDPGP PF01704.18 AMD21713.1 - 4.1e-55 187.1 0.0 5.3e-55 186.7 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 AMD21713.1 - 0.042 14.2 0.0 0.11 12.8 0.0 2.0 1 1 0 1 1 1 0 MobA-like NTP transferase domain PhoLip_ATPase_C PF16212.5 AMD21714.1 - 3.4e-67 226.8 31.1 3.4e-67 226.8 31.1 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AMD21714.1 - 5e-21 74.1 7.0 2e-20 72.2 1.0 2.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 AMD21714.1 - 7.5e-15 55.8 0.1 7.9e-07 29.6 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AMD21714.1 - 6.8e-12 45.3 0.0 3.2e-11 43.1 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 AMD21714.1 - 3.6e-10 39.7 0.4 1e-08 34.9 0.0 3.0 2 2 1 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AMD21714.1 - 0.0075 16.0 0.0 0.031 14.0 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase EPL1 PF10513.9 AMD21714.1 - 0.2 12.1 1.7 0.59 10.5 1.7 1.7 1 0 0 1 1 1 0 Enhancer of polycomb-like DUF202 PF02656.15 AMD21714.1 - 0.27 11.7 2.0 18 5.9 0.0 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DnaJ PF00226.31 AMD21715.1 - 5.1e-25 87.4 1.4 9.4e-25 86.5 1.4 1.5 1 0 0 1 1 1 1 DnaJ domain DNA_pol_B PF00136.21 AMD21716.1 - 1.8e-141 472.0 0.5 2.3e-141 471.6 0.5 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AMD21716.1 - 2.4e-83 280.1 0.1 5e-83 279.0 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 AMD21716.1 - 6.4e-17 61.8 4.7 1.7e-16 60.4 4.7 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 AMD21716.1 - 2.5e-05 23.3 1.6 0.0039 16.1 0.2 3.0 2 1 1 3 3 3 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 AMD21716.1 - 0.00012 21.8 0.0 0.00029 20.6 0.0 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AMD21716.1 - 0.0088 16.1 0.3 0.054 13.5 0.3 2.3 1 1 0 1 1 1 1 RNase_H superfamily DnaJ_CXXCXGXG PF00684.19 AMD21716.1 - 1.3 9.4 7.0 3.2 8.2 7.0 1.7 1 0 0 1 1 1 0 DnaJ central domain zf-ACC PF17848.1 AMD21716.1 - 8 6.6 8.1 1.1 9.4 2.2 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Pkinase PF00069.25 AMD21717.1 - 7.2e-69 232.1 0.0 8.9e-69 231.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21717.1 - 1.4e-33 116.3 0.0 1.9e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AMD21717.1 - 3e-17 62.7 0.3 6.4e-17 61.7 0.3 1.6 1 0 0 1 1 1 1 FHA domain Pkinase_fungal PF17667.1 AMD21717.1 - 3.6e-06 26.0 0.1 4.7e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 AMD21717.1 - 7.5e-06 26.2 0.0 2.2e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 AMD21717.1 - 0.00026 20.4 0.7 0.00038 19.9 0.7 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 AMD21717.1 - 0.0019 17.8 0.7 0.0032 17.0 0.7 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.6 AMD21717.1 - 0.0022 17.4 0.6 5.2 6.3 0.0 3.1 2 1 1 3 3 3 2 Kinase-like FTA2 PF13095.6 AMD21717.1 - 0.1 12.2 0.6 1.4 8.5 0.1 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 ATG16 PF08614.11 AMD21719.1 - 1.1e-09 38.8 3.8 1.6e-09 38.3 3.8 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 AMD21719.1 - 0.0022 18.2 0.8 0.0029 17.8 0.8 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding HIP1_clath_bdg PF16515.5 AMD21719.1 - 0.011 16.4 0.8 0.019 15.6 0.2 1.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 AMD21719.1 - 0.017 15.6 0.7 0.02 15.4 0.7 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region Fez1 PF06818.15 AMD21719.1 - 0.026 15.0 1.1 0.031 14.7 1.1 1.1 1 0 0 1 1 1 0 Fez1 ArsA_ATPase PF02374.15 AMD21720.1 - 2.6e-115 384.8 0.2 3e-115 384.6 0.2 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 AMD21720.1 - 6.3e-11 42.5 0.4 3.9e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 AMD21720.1 - 9e-08 32.2 0.0 1.8e-07 31.3 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 AMD21720.1 - 0.00068 19.2 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 AMD21720.1 - 0.0018 17.8 2.2 0.015 14.8 0.5 2.5 2 1 1 3 3 3 1 NUBPL iron-transfer P-loop NTPase AAA_25 PF13481.6 AMD21720.1 - 0.074 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsbRD_N PF14361.6 AMD21721.1 - 0.016 15.9 1.5 0.05 14.3 1.5 1.9 1 0 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain INTS5_N PF14837.6 AMD21721.1 - 0.017 14.7 0.5 0.031 13.9 0.5 1.4 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus Gly_acyl_tr_N PF06021.11 AMD21721.1 - 0.02 15.0 3.3 0.02 15.0 3.3 2.3 1 1 1 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DivIC PF04977.15 AMD21721.1 - 0.049 13.4 1.3 0.049 13.4 1.3 3.6 3 1 1 4 4 4 0 Septum formation initiator SlyX PF04102.12 AMD21721.1 - 0.62 10.7 8.2 0.74 10.5 1.0 3.0 3 0 0 3 3 3 0 SlyX TSC22 PF01166.18 AMD21721.1 - 5.5 7.4 8.4 7.2 7.0 0.0 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family Ribosomal_S8 PF00410.19 AMD21722.1 - 2.5e-11 43.6 0.0 1.5e-10 41.1 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein S8 zf-met PF12874.7 AMD21724.1 - 1.2e-06 28.7 1.2 1.2e-06 28.7 1.2 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD21724.1 - 2.5e-05 24.4 1.4 6e-05 23.2 1.4 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-DBF PF07535.12 AMD21724.1 - 0.03 14.4 1.2 0.03 14.4 1.2 2.5 3 0 0 3 3 3 0 DBF zinc finger SNRNP27 PF08648.12 AMD21724.1 - 0.091 12.8 0.3 0.091 12.8 0.3 2.1 2 0 0 2 2 2 0 U4/U6.U5 small nuclear ribonucleoproteins zf-C2H2_4 PF13894.6 AMD21724.1 - 0.1 13.5 0.6 0.25 12.3 0.6 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AMD21724.1 - 0.35 11.4 1.5 0.73 10.4 1.5 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type RPN6_N PF18055.1 AMD21725.1 - 1e-38 132.3 2.1 1e-38 132.3 2.1 2.1 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 AMD21725.1 - 6.9e-18 65.1 0.0 2.3e-17 63.4 0.0 2.0 1 0 0 1 1 1 1 PCI domain RPN6_C_helix PF18503.1 AMD21725.1 - 1.2e-11 44.1 0.5 2.3e-11 43.2 0.5 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_16 PF13432.6 AMD21725.1 - 0.00015 22.4 0.2 0.2 12.3 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 AMD21725.1 - 0.0083 16.4 9.1 1.1 9.6 0.4 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 AMD21725.1 - 0.02 15.4 5.0 3.9 8.1 0.4 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat DDRGK PF09756.9 AMD21725.1 - 0.074 12.6 2.3 0.16 11.6 0.0 2.4 2 1 0 3 3 3 0 DDRGK domain TPR_MalT PF17874.1 AMD21725.1 - 0.12 11.7 5.0 0.46 9.8 0.5 2.2 2 0 0 2 2 2 0 MalT-like TPR region TPR_2 PF07719.17 AMD21725.1 - 0.42 10.9 8.0 5.4 7.4 0.2 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat PMT PF02366.18 AMD21726.1 - 2e-82 276.5 19.0 2e-82 276.5 19.0 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AMD21726.1 - 3.4e-59 199.8 15.3 3.4e-59 199.8 15.3 2.3 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AMD21726.1 - 7.3e-50 169.4 1.2 1.3e-49 168.6 1.2 1.4 1 0 0 1 1 1 1 MIR domain DUF3291 PF11695.8 AMD21726.1 - 0.12 12.1 0.2 2.5 7.8 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3291) Glug PF07581.12 AMD21726.1 - 3.8 8.1 7.4 0.6 10.6 2.8 2.1 2 0 0 2 2 2 0 The GLUG motif MFS_1 PF07690.16 AMD21727.1 - 2.7e-15 56.1 14.9 4.8e-15 55.3 14.9 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 AMD21727.1 - 7.3e-12 45.3 2.4 7.3e-12 45.3 2.4 3.0 3 1 1 4 4 4 1 Nodulin-like SRP14 PF02290.15 AMD21728.1 - 3.1e-19 69.1 0.0 5.4e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle 14kD protein UBX PF00789.20 AMD21729.1 - 1.9e-13 50.4 0.0 5.1e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 UBX domain Prenyltrans PF00432.21 AMD21730.1 - 5.8e-35 118.7 9.3 3.3e-12 45.9 1.6 6.2 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat DUF4576 PF15144.6 AMD21730.1 - 0.091 12.6 0.0 2.9 7.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) Lenti_VIF_2 PF07401.12 AMD21731.1 - 0.078 12.3 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Bovine Lentivirus VIF protein DUF2418 PF10332.9 AMD21732.1 - 1.5e-18 67.1 3.6 1.7e-18 66.9 0.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) CagD PF16567.5 AMD21732.1 - 0.041 13.7 0.0 0.071 12.9 0.0 1.3 1 0 0 1 1 1 0 Pathogenicity island component CagD Mt_ATP-synt_B PF05405.14 AMD21732.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Nup35_RRM PF05172.13 AMD21733.1 - 1.4e-33 114.9 0.0 2.9e-33 113.8 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 AMD21733.1 - 0.018 15.0 0.0 0.075 13.0 0.0 2.0 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif LUC7 PF03194.15 AMD21734.1 - 1.8e-55 188.4 6.8 2.2e-55 188.1 6.8 1.0 1 0 0 1 1 1 1 LUC7 N_terminus FlaC_arch PF05377.11 AMD21734.1 - 0.026 14.9 2.3 0.19 12.1 1.6 2.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Rho_Binding PF08912.11 AMD21734.1 - 0.11 13.3 2.4 0.35 11.7 0.3 2.7 3 0 0 3 3 3 0 Rho Binding adh_short PF00106.25 AMD21735.1 - 2.7e-05 23.7 0.0 0.00012 21.6 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase Peptidase_S24 PF00717.23 AMD21736.1 - 6.3e-07 29.3 0.1 6.8e-06 26.0 0.0 2.2 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 AMD21736.1 - 0.0023 17.7 0.0 0.0043 16.9 0.0 1.5 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Ribophorin_II PF05817.14 AMD21737.1 - 4.7e-17 61.8 1.4 5.4e-17 61.6 1.4 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF4083 PF13314.6 AMD21737.1 - 0.035 14.0 0.1 0.035 14.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) Osw5 PF17062.5 AMD21738.1 - 3.7e-21 75.0 10.9 5.1e-21 74.5 10.9 1.2 1 0 0 1 1 1 1 Outer spore wall 5 WD40 PF00400.32 AMD21740.1 - 4.3e-24 84.3 1.3 1e-05 26.1 0.2 6.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21740.1 - 6.8e-10 39.1 0.0 0.03 14.6 0.0 5.0 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD21740.1 - 1.5e-05 25.0 0.1 0.0017 18.3 0.0 2.8 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 AMD21740.1 - 0.042 12.4 0.3 1.2 7.6 0.1 2.7 1 1 2 3 3 3 0 Cytochrome D1 heme domain 4F5 PF04419.14 AMD21741.1 - 1.6e-09 38.5 11.2 1.6e-09 38.5 11.2 2.3 2 0 0 2 2 2 1 4F5 protein family Pyr_redox_2 PF07992.14 AMD21742.1 - 2.9e-47 161.3 0.0 3.7e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AMD21742.1 - 1.6e-11 44.6 0.0 2e-10 41.1 0.0 2.8 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AMD21742.1 - 0.00015 21.1 0.2 2.9 7.1 0.0 3.8 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Phage_Mu_Gam PF07352.12 AMD21742.1 - 0.051 13.5 0.8 0.17 11.8 0.3 2.1 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein HTH_Tnp_Tc5 PF03221.16 AMD21743.1 - 0.054 13.5 0.1 0.2 11.7 0.1 2.0 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DUF455 PF04305.14 AMD21743.1 - 0.07 12.7 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF455) HTH_psq PF05225.16 AMD21743.1 - 0.12 12.1 0.1 0.38 10.5 0.1 1.9 2 0 0 2 2 2 0 helix-turn-helix, Psq domain Kinesin_assoc PF16183.5 AMD21743.1 - 0.62 10.2 2.0 7.7 6.6 0.0 2.6 2 1 0 2 2 2 0 Kinesin-associated DEAD PF00270.29 AMD21744.1 - 6.3e-35 120.5 0.0 1e-34 119.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD21744.1 - 1.9e-27 95.8 0.4 4.2e-25 88.3 0.1 2.6 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 AMD21744.1 - 5.5e-09 36.3 0.0 1.2e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 AMD21744.1 - 0.071 12.4 0.1 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Ribosomal_S9 PF00380.19 AMD21746.1 - 2.2e-32 112.1 0.3 2.5e-32 111.9 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13e PF01294.18 AMD21747.1 - 4.6e-68 228.6 4.1 8e-68 227.8 4.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_60s PF00428.19 AMD21748.1 - 2.2e-23 82.6 12.3 2.7e-23 82.3 12.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF1420 PF07220.11 AMD21748.1 - 0.16 10.5 0.0 0.17 10.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1420) zf-C3HC4_3 PF13920.6 AMD21749.1 - 0.049 13.5 5.3 0.27 11.1 3.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPP_enzyme_N PF02776.18 AMD21750.1 - 7.7e-31 107.0 0.0 1.2e-30 106.4 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AMD21750.1 - 1.4e-18 67.0 0.0 3.1e-18 65.8 0.0 1.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AMD21750.1 - 1.4e-11 44.4 0.0 3.1e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Pkinase PF00069.25 AMD21751.1 - 3e-62 210.4 0.0 3.6e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21751.1 - 2.6e-25 89.2 0.0 4e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AMD21751.1 - 0.00078 19.4 0.3 0.0066 16.4 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 AMD21751.1 - 0.0018 17.7 0.0 0.027 13.8 0.0 2.2 1 1 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 AMD21751.1 - 0.012 15.2 0.6 0.064 12.8 0.0 1.9 1 1 0 2 2 2 0 Choline/ethanolamine kinase RICTOR_M PF14666.6 AMD21751.1 - 0.02 14.6 0.2 0.045 13.5 0.2 1.6 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain Kdo PF06293.14 AMD21751.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ldh_1_N PF00056.23 AMD21752.1 - 3.2e-41 140.7 0.2 5.3e-41 140.0 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 AMD21752.1 - 3.8e-34 118.0 0.0 6.6e-34 117.2 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 AMD21752.1 - 0.0053 15.8 0.0 0.0083 15.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Arf PF00025.21 AMD21753.1 - 3.2e-42 143.9 0.0 3.8e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 AMD21753.1 - 2.2e-10 40.3 0.2 2e-06 27.2 0.0 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 AMD21753.1 - 7.6e-09 35.8 0.0 1.1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 AMD21753.1 - 1.7e-08 34.1 0.0 2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 AMD21753.1 - 1.7e-05 24.5 0.0 2.2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 AMD21753.1 - 4.3e-05 23.1 0.0 0.0014 18.2 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 AMD21753.1 - 0.0037 16.9 0.0 0.25 10.9 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 AMD21753.1 - 0.0037 17.3 0.0 0.006 16.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 AMD21753.1 - 0.08 12.4 0.0 0.12 11.8 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DRMBL PF07522.14 AMD21754.1 - 2.1e-21 76.2 0.1 4.4e-21 75.1 0.1 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 AMD21754.1 - 0.00054 19.5 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF4776 PF16003.5 AMD21754.1 - 2.1 7.2 5.6 0.23 10.4 1.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) Cwf_Cwc_15 PF04889.12 AMD21754.1 - 2.6 7.7 6.5 4 7.1 6.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 AMD21754.1 - 5.2 6.1 10.6 7.3 5.6 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) GATA PF00320.27 AMD21755.1 - 6.1e-14 51.3 3.3 6.1e-14 51.3 3.3 1.8 2 0 0 2 2 2 1 GATA zinc finger CLTH PF10607.9 AMD21756.1 - 2.7e-23 82.5 3.0 2.7e-23 82.5 3.0 2.0 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Meiotic_rec114 PF03525.14 AMD21758.1 - 1.4e-07 30.8 2.2 2.1e-07 30.2 2.2 1.5 1 1 0 1 1 1 1 Meiotic recombination protein rec114 DTC PF18102.1 AMD21758.1 - 0.075 13.2 0.3 0.32 11.1 0.0 2.1 3 0 0 3 3 3 0 Deltex C-terminal domain NFACT-R_1 PF05670.13 AMD21759.1 - 3.2e-33 114.6 0.0 5.7e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain Retrotrans_gag PF03732.17 AMD21759.1 - 0.09 13.1 1.3 0.19 12.0 1.3 1.5 1 0 0 1 1 1 0 Retrotransposon gag protein CAF1C_H4-bd PF12265.8 AMD21760.1 - 7.3e-14 51.8 0.1 2e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AMD21760.1 - 5.9e-09 36.4 8.9 0.00085 20.1 0.1 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21760.1 - 7.6e-07 29.4 3.5 0.0047 17.2 0.6 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AMD21760.1 - 0.016 14.2 0.3 17 4.3 0.2 3.1 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TEX19 PF15553.6 AMD21760.1 - 0.15 12.0 4.2 0.1 12.5 0.4 2.4 2 0 0 2 2 2 0 Testis-expressed protein 19 RIC1 PF07064.13 AMD21761.1 - 9.2e-14 51.5 0.0 1e-12 48.0 0.0 2.6 2 1 0 2 2 2 1 RIC1 COX6B PF02297.17 AMD21762.1 - 2.2e-20 72.7 5.1 2.6e-20 72.4 5.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 AMD21762.1 - 0.029 14.4 1.3 0.051 13.6 1.3 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, HAD_2 PF13419.6 AMD21763.1 - 1.5e-11 44.7 0.0 2.3e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AMD21763.1 - 3.1e-06 27.6 0.0 6e-06 26.7 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AMD21763.1 - 3.5e-05 23.8 0.0 7.8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HEPN_Cthe2314 PF18730.1 AMD21763.1 - 0.0035 17.4 0.1 0.0062 16.6 0.1 1.5 1 0 0 1 1 1 1 Cthe_2314-like HEPN Y_Y_Y PF07495.13 AMD21764.1 - 9.5 6.3 7.1 9.3 6.3 0.2 3.2 3 0 0 3 3 3 0 Y_Y_Y domain Nramp PF01566.18 AMD21765.1 - 1.5e-92 310.4 19.1 2.1e-92 309.9 19.1 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Bromodomain PF00439.25 AMD21766.1 - 2.7e-05 24.2 0.0 7e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Bromodomain HA2 PF04408.23 AMD21767.1 - 5.1e-26 91.1 0.0 5.1e-26 91.1 0.0 3.0 3 1 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AMD21767.1 - 4.4e-14 52.8 0.4 3.2e-11 43.6 0.0 3.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AMD21767.1 - 1.6e-11 44.4 0.0 4.3e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 AMD21767.1 - 3.4e-09 36.7 0.0 8.9e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AMD21767.1 - 4.5e-06 27.0 0.1 1.5e-05 25.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 AMD21767.1 - 0.0046 16.3 2.9 0.012 15.0 0.0 2.7 3 0 0 3 3 3 1 KaiC AAA_19 PF13245.6 AMD21767.1 - 0.0047 17.3 0.0 0.016 15.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AMD21767.1 - 0.025 14.3 0.0 0.068 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AMD21767.1 - 0.036 14.6 0.2 0.036 14.6 0.2 4.3 2 2 0 2 2 1 0 AAA domain PhoH PF02562.16 AMD21767.1 - 0.041 13.3 0.0 0.1 12.0 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 AMD21767.1 - 0.041 12.9 0.0 0.1 11.6 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein Yae1_N PF09811.9 AMD21767.1 - 0.29 10.8 1.7 0.55 10.0 1.7 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal MOZ_SAS PF01853.18 AMD21768.1 - 1.6e-56 190.8 0.6 2.5e-56 190.2 0.6 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 AMD21768.1 - 1e-07 31.5 5.3 5.3e-06 25.9 1.9 2.6 2 0 0 2 2 2 2 MYST family zinc finger domain Acetyltransf_7 PF13508.7 AMD21768.1 - 0.00052 20.4 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AMD21768.1 - 0.00099 19.3 0.0 0.0034 17.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family zf-C2H2_4 PF13894.6 AMD21768.1 - 0.13 13.1 2.4 0.22 12.5 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger SNF2_N PF00176.23 AMD21769.1 - 5.6e-70 235.8 0.0 9.1e-70 235.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD21769.1 - 3.9e-16 59.4 0.0 1.5e-14 54.3 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HIRAN PF08797.11 AMD21769.1 - 7.4e-12 45.0 0.0 1.5e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain zf-RING_2 PF13639.6 AMD21769.1 - 3.3e-08 33.7 11.9 8.4e-08 32.4 11.9 1.7 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 AMD21769.1 - 8.4e-07 29.1 0.0 3.7e-06 27.1 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 AMD21769.1 - 3.3e-06 26.9 9.4 6.3e-06 26.0 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD21769.1 - 2.8e-05 23.9 13.2 5.9e-05 22.9 13.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD21769.1 - 0.00017 21.4 11.9 0.00035 20.5 11.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AMD21769.1 - 0.0032 17.4 10.4 0.007 16.4 10.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 AMD21769.1 - 0.028 14.7 6.6 0.08 13.2 6.6 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AMD21769.1 - 0.029 14.4 1.9 0.062 13.4 1.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 AMD21769.1 - 0.037 13.9 11.1 0.082 12.8 11.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 AMD21769.1 - 0.085 13.0 6.9 0.24 11.6 6.9 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 AMD21769.1 - 1.3 9.3 12.3 3 8.1 12.3 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 AMD21769.1 - 1.6 8.6 10.1 4.4 7.1 10.1 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 AMD21769.1 - 1.9 8.3 8.2 5.3 6.9 8.2 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit CDC24_OB1 PF17246.2 AMD21770.1 - 0.037 14.2 0.3 0.072 13.2 0.3 1.4 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 1 Phage_holin_3_6 PF07332.11 AMD21770.1 - 0.48 10.5 4.3 0.82 9.7 4.3 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III MIF4G_like PF09088.11 AMD21771.1 - 2.5e-53 180.7 0.6 4.9e-53 179.7 0.6 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 AMD21771.1 - 3e-50 171.2 5.5 1.2e-49 169.2 2.0 2.6 2 1 0 2 2 2 1 MIF4G like MIF4G PF02854.19 AMD21771.1 - 1.5e-10 41.0 0.3 1.5e-10 41.0 0.3 2.2 3 0 0 3 3 3 1 MIF4G domain Collagen PF01391.18 AMD21772.1 - 0.034 13.9 17.6 0.16 11.8 13.4 3.0 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) Pkr1 PF08636.10 AMD21773.1 - 5.4e-30 103.3 7.8 6.2e-30 103.2 7.8 1.0 1 0 0 1 1 1 1 ER protein Pkr1 VEGFR-2_TMD PF17988.1 AMD21773.1 - 0.005 16.2 3.0 0.005 16.2 3.0 1.9 2 0 0 2 2 2 1 VEGFR-2 Transmembrane domain AzlC PF03591.14 AMD21773.1 - 0.025 15.0 3.2 0.032 14.7 3.2 1.1 1 0 0 1 1 1 0 AzlC protein EloA-BP1 PF15870.5 AMD21774.1 - 0.088 13.1 1.2 0.1 12.9 1.2 1.2 1 0 0 1 1 1 0 ElonginA binding-protein 1 PH_12 PF16457.5 AMD21774.1 - 1.1 9.8 5.2 0.92 10.0 3.6 1.6 1 1 1 2 2 2 0 Pleckstrin homology domain Ribosomal_L15e PF00827.17 AMD21776.1 - 6.1e-89 296.8 12.5 7.5e-89 296.5 12.5 1.0 1 0 0 1 1 1 1 Ribosomal L15 AICARFT_IMPCHas PF01808.18 AMD21777.1 - 1.4e-93 313.6 0.0 2.2e-93 313.0 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 AMD21777.1 - 6e-24 84.1 0.3 1.6e-23 82.7 0.0 1.8 2 0 0 2 2 2 1 MGS-like domain zf-C3HC4_3 PF13920.6 AMD21778.1 - 2.2e-08 33.8 12.9 4.7e-08 32.8 12.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AMD21778.1 - 0.087 12.7 11.7 0.18 11.7 11.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 YL1 PF05764.13 AMD21778.1 - 0.38 10.8 5.7 0.64 10.1 5.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Aminotran_1_2 PF00155.21 AMD21779.1 - 9.8e-81 271.7 0.0 1.1e-80 271.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SNARE PF05739.19 AMD21780.1 - 1.4e-15 57.0 2.7 1.8e-15 56.7 0.9 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 AMD21780.1 - 2.8e-07 30.4 11.7 0.00035 20.3 0.9 2.4 2 0 0 2 2 2 2 Syntaxin Syntaxin-5_N PF11416.8 AMD21780.1 - 2.7e-05 23.3 2.3 4.1e-05 22.7 0.1 2.4 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin-18_N PF10496.9 AMD21780.1 - 4.5e-05 23.6 0.0 0.00016 21.9 0.0 2.0 1 0 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus Cluap1 PF10234.9 AMD21780.1 - 0.012 15.0 1.2 0.012 15.0 1.2 2.3 2 1 0 2 2 2 0 Clusterin-associated protein-1 MCPsignal PF00015.21 AMD21780.1 - 0.015 15.1 8.0 0.024 14.5 1.1 2.9 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain betaPIX_CC PF16523.5 AMD21780.1 - 0.041 13.7 2.9 0.23 11.3 0.2 2.7 2 1 1 3 3 3 0 betaPIX coiled coil DUF1664 PF07889.12 AMD21780.1 - 0.047 13.7 10.2 1 9.4 1.0 3.4 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) Vac_Fusion PF02346.16 AMD21780.1 - 0.05 13.2 0.2 6.1 6.6 0.0 2.8 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 TBCA PF02970.16 AMD21780.1 - 0.17 12.3 6.0 0.2 12.0 0.4 2.5 2 0 0 2 2 2 0 Tubulin binding cofactor A Prominin PF05478.11 AMD21780.1 - 0.17 9.8 6.5 0.03 12.3 0.6 2.0 2 0 0 2 2 2 0 Prominin Glutaredoxin2_C PF04399.13 AMD21780.1 - 0.22 11.4 5.5 7.9 6.3 0.2 3.7 3 1 1 4 4 4 0 Glutaredoxin 2, C terminal domain Fmp27_WPPW PF10359.9 AMD21780.1 - 0.33 9.8 9.3 0.066 12.1 3.4 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Serine_rich PF08824.10 AMD21780.1 - 0.34 10.9 6.0 4.6 7.2 0.1 2.9 2 1 0 2 2 2 0 Serine rich protein interaction domain WXG100 PF06013.12 AMD21780.1 - 0.34 11.2 3.0 2.1 8.6 0.1 3.0 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Syntaxin_2 PF14523.6 AMD21780.1 - 0.39 11.1 14.4 6 7.3 4.3 4.1 2 1 1 3 3 3 0 Syntaxin-like protein Nmad5 PF18757.1 AMD21780.1 - 0.44 10.7 5.0 0.62 10.2 0.2 2.5 2 1 0 2 2 2 0 Nucleotide modification associated domain 5 USP8_interact PF08941.10 AMD21780.1 - 0.5 10.1 4.6 3.9 7.3 0.0 2.8 3 1 0 3 3 2 0 USP8 interacting DUF2408 PF10303.9 AMD21780.1 - 0.61 10.6 4.4 0.94 10.0 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) DUF16 PF01519.16 AMD21780.1 - 0.69 10.4 9.9 0.059 13.9 1.3 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 AMD21780.1 - 0.85 10.1 8.2 6.5 7.3 0.7 3.4 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein HrpB7 PF09486.10 AMD21780.1 - 1.1 9.7 6.1 0.38 11.1 1.1 2.3 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF724 PF05266.14 AMD21780.1 - 1.3 8.8 7.7 10 5.9 1.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF724) GIT1_C PF12205.8 AMD21780.1 - 1.5 9.0 6.3 4.6 7.4 1.5 2.6 2 1 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF745 PF05335.13 AMD21780.1 - 3.2 7.4 11.5 4.3 7.0 2.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF745) V-SNARE PF05008.15 AMD21780.1 - 3.2 8.2 6.3 1.7 9.0 0.6 3.1 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus FlaC_arch PF05377.11 AMD21780.1 - 5.9 7.4 7.8 8.2 6.9 0.6 3.9 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) YabA PF06156.13 AMD21780.1 - 7.5 7.3 7.2 17 6.1 0.1 3.4 2 1 1 3 3 3 0 Initiation control protein YabA UPF0242 PF06785.11 AMD21780.1 - 7.5 6.6 15.3 3 7.9 3.2 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Snf7 PF03357.21 AMD21781.1 - 1.5e-52 177.7 12.6 1.5e-52 177.7 12.6 1.9 2 0 0 2 2 2 1 Snf7 PspA_IM30 PF04012.12 AMD21781.1 - 0.033 13.8 16.4 0.1 12.1 16.4 2.0 1 1 0 1 1 1 0 PspA/IM30 family Misat_Tub_SegII PF10644.9 AMD21781.1 - 0.26 11.6 2.1 0.3 11.4 0.4 1.9 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain Cupin_8 PF13621.6 AMD21781.1 - 0.34 10.6 1.8 0.47 10.1 1.6 1.3 1 1 0 1 1 1 0 Cupin-like domain DUF572 PF04502.13 AMD21781.1 - 6.1 6.4 11.0 4.2 6.9 9.1 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF572) PRP9_N PF16958.5 AMD21781.1 - 8.3 6.4 10.2 5.4 7.0 8.1 1.7 1 1 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus GAIN_A PF18619.1 AMD21782.1 - 0.0021 18.2 0.5 0.0055 16.9 0.5 1.8 1 0 0 1 1 1 1 GPCR-Autoproteolysis-INducing (GAIN) subdomain A NUDE_C PF04880.13 AMD21782.1 - 0.0098 16.4 0.8 0.018 15.5 0.8 1.4 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region HALZ PF02183.18 AMD21782.1 - 0.0098 16.1 1.0 0.025 14.8 1.0 1.7 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.15 AMD21782.1 - 0.088 12.6 0.6 0.17 11.6 0.6 1.4 1 0 0 1 1 1 0 Septum formation initiator Sdh_cyt PF01127.22 AMD21783.1 - 2.4e-28 98.6 2.6 3.2e-28 98.2 2.6 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Pkinase PF00069.25 AMD21784.1 - 1.5e-76 257.3 0.0 1.9e-76 257.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21784.1 - 6.9e-34 117.3 0.0 9.2e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD21784.1 - 7.3e-09 35.0 1.1 1.6e-08 33.9 1.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AMD21784.1 - 3.8e-06 26.4 0.0 1.1e-05 24.9 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AMD21784.1 - 0.0012 17.8 0.4 0.0031 16.4 0.1 1.7 1 1 1 2 2 2 1 Fungal protein kinase Imm64 PF15600.6 AMD21784.1 - 0.026 14.2 0.2 0.63 9.7 0.5 2.1 2 0 0 2 2 2 0 Immunity protein 64 APH PF01636.23 AMD21784.1 - 0.031 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 AMD21784.1 - 0.063 12.3 0.1 0.13 11.3 0.1 1.5 1 1 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 AMD21784.1 - 0.087 12.2 0.4 0.28 10.5 0.4 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DASH_Hsk3 PF08227.11 AMD21785.1 - 2.8e-19 69.2 5.0 3.7e-19 68.8 5.0 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like DUF2205 PF10224.9 AMD21785.1 - 0.071 13.1 1.1 0.11 12.5 1.1 1.3 1 1 0 1 1 1 0 Short coiled-coil protein Spc24 PF08286.11 AMD21786.1 - 1.5e-19 70.2 0.1 1.5e-19 70.2 0.1 2.4 1 1 0 2 2 2 1 Spc24 subunit of Ndc80 Exonuc_VII_L PF02601.15 AMD21786.1 - 0.0089 15.6 7.9 0.011 15.3 7.9 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit NdhM PF10664.9 AMD21786.1 - 0.053 13.8 1.1 0.19 12.0 1.0 2.0 1 1 1 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M Glyco_hydr_30_2 PF14587.6 AMD21786.1 - 0.063 12.9 0.3 0.08 12.5 0.3 1.1 1 0 0 1 1 1 0 O-Glycosyl hydrolase family 30 BssS PF13991.6 AMD21786.1 - 0.21 11.7 2.6 0.22 11.6 1.1 1.9 1 1 0 1 1 1 0 BssS protein family FapA PF03961.13 AMD21786.1 - 0.78 8.3 4.6 0.95 8.0 4.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Phage_GPO PF05929.11 AMD21786.1 - 1.5 8.4 8.0 2 8.0 8.0 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Seryl_tRNA_N PF02403.22 AMD21786.1 - 3.3 8.0 12.1 17 5.7 5.3 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMPIT PF07851.13 AMD21786.1 - 7.5 5.7 7.7 9.4 5.4 7.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein L31 PF09784.9 AMD21787.1 - 8.5e-42 141.7 1.4 1.4e-41 141.1 1.4 1.3 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L31 DUF1639 PF07797.14 AMD21787.1 - 0.072 13.1 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) Cmc1 PF08583.10 AMD21788.1 - 4.2e-17 61.9 2.6 5.7e-17 61.5 2.6 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.17 AMD21788.1 - 0.028 14.7 1.3 0.041 14.1 1.3 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb CX9C PF16860.5 AMD21788.1 - 0.028 14.4 5.1 0.063 13.3 5.1 1.6 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX17 PF05051.13 AMD21788.1 - 0.032 14.6 0.7 0.032 14.6 0.7 2.2 3 0 0 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) Pet191_N PF10203.9 AMD21788.1 - 0.12 12.7 7.0 0.68 10.3 1.8 2.2 1 1 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Adaptin_N PF01602.20 AMD21789.1 - 1.3e-117 393.5 17.5 1.7e-117 393.2 17.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AMD21789.1 - 9.2e-51 172.1 4.5 9.2e-51 172.1 4.5 3.0 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD21789.1 - 9.8e-14 51.5 0.1 1.8e-06 28.2 0.0 4.9 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 AMD21789.1 - 4e-10 39.1 2.4 0.025 14.8 0.0 5.9 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 AMD21789.1 - 0.00061 20.2 0.4 1.3 9.6 0.0 4.0 4 0 0 4 4 4 1 HEAT-like repeat RTP1_C1 PF10363.9 AMD21789.1 - 0.0024 18.1 11.9 0.061 13.5 0.2 5.8 4 1 1 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 Atx10homo_assoc PF09759.9 AMD21789.1 - 0.026 14.5 0.9 0.61 10.1 0.1 3.5 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain DUF3458_C PF17432.2 AMD21789.1 - 0.03 13.7 0.4 6.4 6.1 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3458_C) ARM repeats Arm PF00514.23 AMD21789.1 - 0.076 13.1 1.0 3.7 7.7 0.3 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat WD40 PF00400.32 AMD21790.1 - 1.6e-39 133.2 15.8 2.8e-06 28.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21790.1 - 4e-11 43.1 0.8 0.015 15.6 0.0 5.0 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD21790.1 - 5.3e-07 28.7 8.8 0.0037 16.0 0.1 4.6 2 1 2 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AMD21790.1 - 0.00074 18.6 2.4 0.57 9.1 0.0 4.1 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AMD21790.1 - 0.01 15.7 0.4 0.11 12.4 0.0 2.6 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A DUF1513 PF07433.11 AMD21790.1 - 0.039 13.0 0.1 0.24 10.5 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.11 AMD21790.1 - 0.2 10.4 2.2 0.46 9.2 0.4 2.6 3 1 0 3 3 3 0 Nup133 N terminal like Peptidase_M3 PF01432.20 AMD21791.1 - 1.2e-131 440.2 0.0 1.6e-131 439.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 AMD21791.1 - 0.15 12.4 0.1 1.2 9.5 0.0 2.1 2 0 0 2 2 2 0 Effector protein TPR_12 PF13424.6 AMD21792.1 - 0.16 12.3 12.6 0.84 10.0 0.1 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 AMD21792.1 - 0.78 10.0 7.1 23 5.4 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Tn7_Tnp_TnsA_C PF08721.11 AMD21792.1 - 0.81 10.4 5.2 0.27 11.9 0.6 2.6 3 0 0 3 3 3 0 TnsA endonuclease C terminal TPR_14 PF13428.6 AMD21792.1 - 1.1 10.3 3.7 81 4.5 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 AMD21792.1 - 3.1 8.0 5.7 9.9 6.4 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SRAP PF02586.14 AMD21793.1 - 6.4e-66 222.0 0.1 7.9e-66 221.7 0.1 1.1 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Mur_ligase_M PF08245.12 AMD21794.1 - 2e-07 31.2 0.4 1.1e-06 28.8 0.1 2.5 2 1 0 2 2 2 1 Mur ligase middle domain Mur_ligase_C PF02875.21 AMD21794.1 - 0.075 13.3 0.0 0.22 11.8 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Med11 PF10280.9 AMD21795.1 - 3.6e-11 43.7 1.0 6.1e-11 42.9 1.0 1.5 1 1 0 1 1 1 1 Mediator complex protein GCR1_C PF12550.8 AMD21796.1 - 2.8e-26 91.6 0.2 8.3e-26 90.1 0.2 1.9 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Baculo_F PF12259.8 AMD21796.1 - 0.025 13.1 3.1 0.033 12.7 3.1 1.1 1 0 0 1 1 1 0 Baculovirus F protein Snapin_Pallidin PF14712.6 AMD21796.1 - 0.19 12.1 2.7 0.43 11.0 2.7 1.6 1 0 0 1 1 1 0 Snapin/Pallidin DASH_Dad3 PF08656.10 AMD21796.1 - 0.37 10.9 2.6 9.6 6.4 2.6 2.6 1 1 0 1 1 1 0 DASH complex subunit Dad3 CENP-H PF05837.12 AMD21796.1 - 0.65 10.4 6.0 0.1 13.0 0.9 2.2 3 0 0 3 3 3 0 Centromere protein H (CENP-H) She2p PF11435.8 AMD21797.1 - 2.3e-64 216.8 8.7 2.9e-64 216.5 8.7 1.1 1 0 0 1 1 1 1 RNA binding protein She2p Myosin_head PF00063.21 AMD21798.1 - 1.7e-235 783.4 6.2 2.1e-235 783.1 6.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 AMD21798.1 - 7.8e-45 152.9 0.0 1.3e-44 152.1 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 AMD21798.1 - 3.7e-11 42.4 0.0 6.9e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AMD21798.1 - 3e-07 30.2 0.0 6.9e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AMD21798.1 - 1.1e-05 25.0 0.0 2.7e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Hpr_kinase_C PF07475.12 AMD21798.1 - 0.0094 15.5 0.1 3.8 7.0 0.0 2.5 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain RsgA_GTPase PF03193.16 AMD21798.1 - 0.019 14.9 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 AMD21798.1 - 0.025 14.9 0.0 0.082 13.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AMD21798.1 - 0.032 13.9 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 AMD21798.1 - 0.034 14.5 0.0 0.14 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 AMD21798.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TPP_enzyme_N PF02776.18 AMD21799.1 - 4e-55 186.0 0.0 8.6e-55 185.0 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 AMD21799.1 - 8.7e-47 158.7 0.1 1.4e-45 154.8 0.0 2.7 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 AMD21799.1 - 1.5e-40 138.1 0.5 2.9e-40 137.2 0.5 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain His_Phos_1 PF00300.22 AMD21800.1 - 8.4e-12 45.2 0.0 1.9e-05 24.5 0.0 2.8 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Glyco_tranf_2_4 PF13704.6 AMD21800.1 - 0.13 12.8 0.1 0.22 12.0 0.1 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 SPG4 PF17325.2 AMD21801.1 - 1.2e-33 116.5 0.0 1.6e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Stationary phase protein 4 Glyco_hydro_17 PF00332.18 AMD21802.1 - 1.7e-07 31.2 0.0 4.1e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 TOM6p PF15184.6 AMD21802.1 - 0.15 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog Mid2 PF04478.12 AMD21803.1 - 1.6e-43 148.1 0.6 1.6e-43 148.1 0.6 2.3 2 1 0 2 2 2 1 Mid2 like cell wall stress sensor Insulin_TMD PF17870.1 AMD21803.1 - 0.017 15.2 2.9 0.035 14.2 2.9 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Stevor PF17410.2 AMD21803.1 - 2.1 7.8 4.7 0.85 9.1 0.0 2.0 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame E1-E2_ATPase PF00122.20 AMD21804.1 - 2e-49 167.6 0.8 2e-49 167.6 0.8 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 AMD21804.1 - 2.2e-45 154.6 1.1 2.2e-45 154.6 1.1 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 AMD21804.1 - 4.8e-20 72.7 1.0 3.3e-19 70.0 1.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AMD21804.1 - 2e-15 56.6 0.1 4.2e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AMD21804.1 - 1.4e-13 50.3 0.0 2.8e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AMD21804.1 - 1.2e-05 25.2 1.2 0.00036 20.4 0.9 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AMD21804.1 - 0.056 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase TrbC PF04956.13 AMD21804.1 - 6.8 7.0 8.1 1.8 8.8 0.1 3.5 3 0 0 3 3 3 0 TrbC/VIRB2 family Sua5_yciO_yrdC PF01300.18 AMD21805.1 - 9.7e-48 162.0 0.0 3.1e-47 160.4 0.0 1.8 2 0 0 2 2 2 1 Telomere recombination SUA5 PF03481.13 AMD21805.1 - 6.4e-30 104.4 0.0 9.3e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding FTR1 PF03239.14 AMD21806.1 - 8.5e-88 294.4 9.2 1e-87 294.2 9.2 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family FAD_binding_4 PF01565.23 AMD21806.1 - 0.003 17.3 0.2 0.016 14.9 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Bac_transf PF02397.16 AMD21806.1 - 0.0041 16.8 0.2 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 Bacterial sugar transferase DUF4781 PF16013.5 AMD21806.1 - 0.0048 15.7 1.7 0.27 10.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4781) DUF4131 PF13567.6 AMD21806.1 - 0.55 9.9 5.7 4.4 6.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Copper-fist PF00649.18 AMD21807.1 - 6e-21 73.6 0.8 6e-21 73.6 0.8 2.5 2 1 0 2 2 2 1 Copper fist DNA binding domain Ran-binding PF05508.11 AMD21808.1 - 2.3e-97 325.8 4.3 3.2e-97 325.3 4.3 1.2 1 0 0 1 1 1 1 RanGTP-binding protein SNF2_N PF00176.23 AMD21809.1 - 3.9e-58 196.8 0.0 5.6e-58 196.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 AMD21809.1 - 7.2e-43 146.8 0.2 6.4e-42 143.8 0.2 2.1 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 AMD21809.1 - 1.5e-15 57.5 0.0 3.4e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD21809.1 - 1.5e-06 28.3 0.0 3.6e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AMD21809.1 - 0.0003 20.1 0.2 0.002 17.3 0.1 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 AMD21809.1 - 0.00038 20.3 0.0 0.002 17.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Zn_clus PF00172.18 AMD21810.1 - 0.00036 20.6 0.6 0.00036 20.6 0.6 2.4 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Phage_holin_5_1 PF06946.11 AMD21811.1 - 1.4 9.3 6.1 1.2 9.5 3.5 2.1 1 1 1 2 2 2 0 Bacteriophage A118-like holin, Hol118 Oxysterol_BP PF01237.18 AMD21812.1 - 5.1e-80 269.1 0.0 4.1e-78 262.8 0.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein PPTA PF01239.22 AMD21813.1 - 0.09 12.5 1.5 0.47 10.3 0.1 2.9 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat ThiF PF00899.21 AMD21814.1 - 0.013 14.9 0.9 0.013 14.9 0.9 2.0 2 1 0 3 3 3 0 ThiF family Ribosomal_L50 PF10501.9 AMD21815.1 - 3.8e-23 81.7 0.1 8.1e-23 80.7 0.1 1.5 1 0 0 1 1 1 1 Ribosomal subunit 39S LAMTOR PF15454.6 AMD21816.1 - 2.7e-18 66.3 8.8 4.1e-18 65.7 8.8 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator TT1725 PF18324.1 AMD21816.1 - 0.0014 18.7 0.1 0.0018 18.3 0.1 1.3 1 0 0 1 1 1 1 Hypothetical protein TT1725 DUF4043 PF13252.6 AMD21816.1 - 0.08 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4043) Syntaxin_2 PF14523.6 AMD21816.1 - 0.13 12.7 6.5 0.16 12.4 4.4 1.9 1 1 1 2 2 2 0 Syntaxin-like protein RNAse_A_bac PF18431.1 AMD21816.1 - 0.16 13.0 0.3 2.1 9.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial CdiA-CT RNAse A domain Bromodomain PF00439.25 AMD21817.1 - 1.4e-32 111.6 5.6 3.6e-23 81.4 0.4 2.5 2 0 0 2 2 2 2 Bromodomain DUF1810 PF08837.11 AMD21817.1 - 0.0072 16.1 0.0 0.26 11.1 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1810) LMSTEN PF07988.12 AMD21817.1 - 0.081 12.4 0.2 0.22 11.0 0.2 1.7 1 0 0 1 1 1 0 LMSTEN motif Rad21_Rec8_N PF04825.13 AMD21818.1 - 2.7e-14 53.2 0.0 5.3e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Cyclin_C PF02984.19 AMD21819.1 - 0.13 12.4 2.2 6.4 6.9 0.1 2.2 2 0 0 2 2 2 0 Cyclin, C-terminal domain CRR7 PF12095.8 AMD21819.1 - 0.25 11.8 7.2 0.18 12.2 1.1 2.6 2 1 1 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 NYD-SP28_assoc PF14775.6 AMD21819.1 - 1.3 9.2 4.9 2.2 8.5 0.1 3.2 3 1 0 3 3 3 0 Sperm tail C-terminal domain eIF2A PF08662.11 AMD21820.1 - 1e-75 253.9 0.0 1.4e-74 250.2 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 AMD21820.1 - 0.015 16.1 0.3 44 5.2 0.1 4.3 4 1 1 5 5 5 0 WD domain, G-beta repeat Fascin PF06268.13 AMD21820.1 - 0.084 13.1 0.0 2.8 8.2 0.0 2.5 2 0 0 2 2 2 0 Fascin domain DUF1018 PF06252.12 AMD21820.1 - 0.61 11.1 2.7 2 9.5 2.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) Hamartin PF04388.12 AMD21820.1 - 3.6 6.1 8.9 4.9 5.7 8.9 1.1 1 0 0 1 1 1 0 Hamartin protein MMU163 PF17119.5 AMD21821.1 - 5.9e-11 42.0 1.8 4.2e-08 32.6 1.8 2.5 1 1 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis IlvN PF07991.12 AMD21823.1 - 3.2e-46 156.9 0.0 4.5e-46 156.4 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 AMD21823.1 - 3.4e-40 137.6 0.0 5e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 AMD21823.1 - 0.069 13.7 0.0 0.16 12.6 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Paz_1 PF18349.1 AMD21823.1 - 0.077 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 PAZ domain NAD_binding_2 PF03446.15 AMD21823.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase TAL_FSA PF00923.19 AMD21824.1 - 1.1e-98 330.1 0.8 1.3e-98 329.9 0.8 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Zn_clus PF00172.18 AMD21825.1 - 3.6e-08 33.4 10.0 5.8e-08 32.7 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2439 PF10382.9 AMD21826.1 - 2.6e-22 78.9 2.8 6.5e-22 77.7 1.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) DUF2387 PF09526.10 AMD21826.1 - 0.15 12.2 0.4 4.6 7.5 0.2 2.3 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) LRR_4 PF12799.7 AMD21828.1 - 4.5e-05 23.7 5.2 0.0072 16.7 0.8 4.4 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 AMD21828.1 - 0.27 11.4 1.1 91 3.5 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 AMD21828.1 - 0.42 11.3 7.0 31 5.7 0.3 6.2 6 1 1 7 7 7 0 Leucine Rich Repeat Pkinase PF00069.25 AMD21829.1 - 1.1e-69 234.8 0.0 1.5e-69 234.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21829.1 - 9.7e-32 110.3 0.0 1.5e-31 109.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD21829.1 - 2.6e-05 23.7 0.0 4.3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AMD21829.1 - 7.1e-05 22.3 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AMD21829.1 - 0.0012 17.9 0.1 0.0018 17.3 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 AMD21829.1 - 0.0053 16.4 0.1 0.017 14.7 0.0 1.8 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AMD21829.1 - 0.013 15.4 0.1 0.037 13.9 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family CN_hydrolase PF00795.22 AMD21830.1 - 1.6e-57 194.9 0.0 1.7e-57 194.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ORMDL PF04061.14 AMD21831.1 - 1.3e-56 190.2 5.6 1.5e-56 190.0 5.6 1.0 1 0 0 1 1 1 1 ORMDL family ACBP PF00887.19 AMD21832.1 - 1.5e-27 95.6 1.0 1.6e-27 95.5 1.0 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 AMD21832.1 - 0.009 16.4 0.2 0.062 13.7 0.0 1.8 1 1 1 2 2 2 1 FERM central domain HEAT PF02985.22 AMD21833.1 - 1.2e-19 68.7 13.4 0.00033 20.7 0.1 11.2 11 0 0 11 11 11 4 HEAT repeat HEAT_EZ PF13513.6 AMD21833.1 - 1.8e-11 44.3 8.1 1.5e-07 31.8 0.0 7.7 9 2 1 10 10 10 1 HEAT-like repeat IBN_N PF03810.19 AMD21833.1 - 2.5e-11 43.3 2.3 2.9e-10 39.9 0.4 3.4 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cnd1 PF12717.7 AMD21833.1 - 7e-07 29.4 9.1 0.045 13.8 0.1 5.6 2 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD21833.1 - 4.7e-06 26.9 5.8 0.28 11.6 0.0 7.2 4 2 5 9 9 9 2 HEAT repeats CLASP_N PF12348.8 AMD21833.1 - 2.2e-05 24.1 0.6 1.2 8.7 0.0 4.5 4 1 1 5 5 5 2 CLASP N terminal Arm PF00514.23 AMD21833.1 - 0.00016 21.6 9.4 0.0071 16.4 0.1 5.9 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat SIL1 PF16782.5 AMD21833.1 - 0.00028 20.2 0.2 0.0012 18.2 0.2 2.0 2 0 0 2 2 2 1 Nucleotide exchange factor SIL1 Sec7_N PF12783.7 AMD21833.1 - 0.004 17.1 0.7 0.033 14.1 0.1 2.9 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3347 PF11827.8 AMD21833.1 - 0.005 17.1 2.1 0.023 14.9 0.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3347) RIX1 PF08167.12 AMD21833.1 - 0.031 14.0 0.3 1.4 8.7 0.0 3.9 5 1 2 7 7 7 0 rRNA processing/ribosome biogenesis RICTOR_V PF14668.6 AMD21833.1 - 0.093 13.0 0.0 11 6.4 0.0 3.9 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 RTP1_C1 PF10363.9 AMD21833.1 - 0.21 11.8 4.5 15 5.8 0.2 5.1 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DnaB_bind PF10410.9 AMD21833.1 - 1.4 9.1 5.2 2.2 8.5 0.3 3.5 4 0 0 4 4 4 0 DnaB-helicase binding domain of primase PAP2 PF01569.21 AMD21834.1 - 5.9e-19 68.2 1.4 1e-18 67.4 1.4 1.4 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 AMD21834.1 - 0.053 13.6 0.3 2.8 8.1 0.0 2.3 1 1 1 2 2 2 0 Divergent PAP2 family 6PF2K PF01591.18 AMD21835.1 - 5.2e-59 199.2 0.1 7.3e-59 198.8 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AMD21835.1 - 1.4e-16 60.8 0.0 5.6e-16 58.8 0.0 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AMD21835.1 - 0.012 15.8 0.0 0.031 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 AMD21835.1 - 0.082 12.3 0.0 0.19 11.2 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 tRNA_synthFbeta PF17759.1 AMD21835.1 - 0.16 11.3 0.0 1.1 8.6 0.0 2.2 3 0 0 3 3 3 0 Phenylalanyl tRNA synthetase beta chain CLM domain Ribosomal_L26 PF16906.5 AMD21836.1 - 6.2e-36 122.7 4.9 9.1e-36 122.2 4.9 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 AMD21836.1 - 0.0016 18.3 0.5 0.0052 16.7 0.0 2.0 3 0 0 3 3 3 1 KOW motif TIM21 PF08294.11 AMD21837.1 - 9.1e-52 174.8 0.0 1.2e-51 174.4 0.0 1.1 1 0 0 1 1 1 1 TIM21 Glyco_hydro_72 PF03198.14 AMD21838.1 - 5.1e-137 456.3 0.5 6.8e-137 455.9 0.5 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AMD21838.1 - 2.6e-13 50.5 0.5 7.8e-13 48.9 0.5 1.8 1 0 0 1 1 1 1 X8 domain Glucan_synthase PF02364.15 AMD21839.1 - 0 1354.7 0.1 0 1353.0 0.0 1.9 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AMD21839.1 - 1.4e-41 141.9 0.1 3.9e-41 140.4 0.1 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Abhydrolase_1 PF00561.20 AMD21840.1 - 8.3e-21 74.8 0.0 4.1e-19 69.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AMD21840.1 - 2.7e-12 47.8 0.0 2.8e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD21840.1 - 2.1e-09 37.0 0.0 3.6e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 AMD21840.1 - 7e-08 32.9 0.0 1e-07 32.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 AMD21840.1 - 0.00032 20.5 0.0 0.0044 16.8 0.0 2.0 1 1 0 2 2 2 1 PGAP1-like protein Esterase PF00756.20 AMD21840.1 - 0.005 16.5 0.0 0.0069 16.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydro_lipase PF04083.16 AMD21840.1 - 0.038 13.6 0.1 1.5 8.5 0.1 2.9 3 1 0 3 3 3 0 Partial alpha/beta-hydrolase lipase region Abhydrolase_3 PF07859.13 AMD21840.1 - 0.078 12.8 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Palm_thioest PF02089.15 AMD21840.1 - 0.088 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF915 PF06028.11 AMD21840.1 - 0.097 12.0 0.1 0.33 10.3 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 AMD21840.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Ku_PK_bind PF08785.11 AMD21841.1 - 0.14 12.3 1.7 0.46 10.6 0.1 2.6 3 0 0 3 3 3 0 Ku C terminal domain like Ribosomal_L10 PF00466.20 AMD21842.1 - 1.2e-25 89.5 0.2 2.2e-25 88.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 AMD21842.1 - 6.7e-22 77.3 0.0 1.1e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 AMD21842.1 - 2.4e-19 69.7 3.6 2.4e-19 69.7 3.6 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein Alba PF01918.21 AMD21843.1 - 5.7e-07 29.3 0.1 8.6e-07 28.7 0.1 1.3 1 0 0 1 1 1 1 Alba EMP24_GP25L PF01105.24 AMD21845.1 - 6.1e-44 150.1 0.6 6.9e-44 150.0 0.6 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Phage_Coat_Gp8 PF05371.12 AMD21845.1 - 0.051 13.3 3.2 12 5.7 0.0 3.1 3 0 0 3 3 3 0 Phage major coat protein, Gp8 ANAPC4_WD40 PF12894.7 AMD21846.1 - 2.5e-10 40.5 1.1 0.0052 17.0 0.0 3.9 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD21846.1 - 5e-10 39.8 11.1 0.064 14.2 1.8 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat Lgl_C PF08596.10 AMD21846.1 - 0.013 14.2 0.1 0.15 10.7 0.1 2.1 2 0 0 2 2 2 0 Lethal giant larvae(Lgl) like, C-terminal eIF2A PF08662.11 AMD21846.1 - 0.019 14.9 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 AMD21847.1 - 1.4e-19 70.0 8.0 0.00032 21.4 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21847.1 - 5.2e-18 65.1 7.1 1.6e-10 41.2 0.4 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD21847.1 - 0.00023 21.1 0.4 0.02 14.8 0.2 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Rep_fac-A_C PF08646.10 AMD21848.1 - 2.8e-58 195.8 1.1 8.4e-56 187.8 0.6 2.5 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 AMD21848.1 - 4.6e-32 109.9 1.9 1.2e-29 102.0 0.1 3.8 4 0 0 4 4 4 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 AMD21848.1 - 1.7e-17 63.1 0.3 1.4e-09 37.8 0.0 4.7 4 0 0 4 4 4 3 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 AMD21848.1 - 6.2e-05 22.8 0.0 0.0029 17.4 0.0 2.9 2 1 0 2 2 2 1 Cell division control protein 24, OB domain 3 Rep-A_N PF04057.12 AMD21848.1 - 0.0063 16.5 0.5 0.025 14.6 0.1 2.1 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain WD40 PF00400.32 AMD21849.1 - 5.7e-13 49.1 8.7 1.2e-05 25.9 0.0 5.4 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD21849.1 - 6.4e-05 23.2 0.2 2.8 8.3 0.0 4.7 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DBB PF14545.6 AMD21849.1 - 0.058 13.3 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Dof, BCAP, and BANK (DBB) motif, Vps53_N PF04100.12 AMD21850.1 - 0.0011 18.0 5.1 0.0014 17.7 5.1 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal Tropomyosin_1 PF12718.7 AMD21850.1 - 0.037 14.2 1.1 0.037 14.2 1.1 2.1 2 1 0 2 2 2 0 Tropomyosin like DUF2097 PF09870.9 AMD21850.1 - 0.071 13.3 0.3 0.071 13.3 0.3 1.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2097) DUF16 PF01519.16 AMD21850.1 - 0.42 11.1 4.0 0.65 10.5 2.0 2.3 2 1 1 3 3 3 0 Protein of unknown function DUF16 ABC_tran_CTD PF16326.5 AMD21850.1 - 0.43 10.9 4.6 0.15 12.4 0.4 2.3 3 0 0 3 3 3 0 ABC transporter C-terminal domain Cation_ATPase_C PF00689.21 AMD21851.1 - 1.9e-44 151.6 6.7 1.9e-44 151.6 6.7 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 AMD21851.1 - 1.4e-37 129.0 0.2 1.4e-37 129.0 0.2 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 AMD21851.1 - 3.4e-18 65.5 0.0 7.7e-18 64.4 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 AMD21851.1 - 4.6e-13 49.9 0.4 3.3e-10 40.6 0.0 2.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 AMD21851.1 - 5.7e-09 35.5 0.0 1.5e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AMD21851.1 - 0.00089 19.1 1.8 0.001 18.9 0.3 1.9 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase DUF2207 PF09972.9 AMD21851.1 - 8.7 5.0 10.2 27 3.4 3.8 3.1 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) tRNA_int_endo PF01974.17 AMD21852.1 - 2.8e-13 49.7 0.0 5.6e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Ribosomal_L10 PF00466.20 AMD21852.1 - 0.12 12.5 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein L10 SKA2 PF16740.5 AMD21853.1 - 0.057 13.2 0.1 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 FOP_dimer PF09398.10 AMD21853.1 - 0.11 12.8 0.1 0.31 11.3 0.1 1.8 1 0 0 1 1 1 0 FOP N terminal dimerisation domain B-block_TFIIIC PF04182.12 AMD21854.1 - 8.4e-16 57.9 0.0 2.7e-15 56.3 0.0 2.0 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC N6-adenineMlase PF10237.9 AMD21855.1 - 2.4e-55 186.7 0.3 2.4e-55 186.7 0.3 1.3 2 0 0 2 2 2 1 Probable N6-adenine methyltransferase 3Beta_HSD PF01073.19 AMD21856.1 - 3.4e-87 292.0 0.0 4.2e-87 291.7 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 AMD21856.1 - 5.3e-28 98.1 0.0 7.3e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 AMD21856.1 - 1.9e-15 57.1 0.0 4.4e-15 55.9 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 AMD21856.1 - 8.3e-13 48.1 0.0 3e-11 43.0 0.0 2.4 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 AMD21856.1 - 1.8e-10 40.4 0.0 2.7e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 AMD21856.1 - 3e-09 37.0 0.0 4.4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 AMD21856.1 - 7.7e-08 31.8 0.0 3.2e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 AMD21856.1 - 0.00075 19.5 0.0 0.0086 16.0 0.0 2.1 1 1 0 1 1 1 1 KR domain Vps8 PF12816.7 AMD21857.1 - 3.2e-53 180.2 7.8 8.7e-51 172.2 4.3 2.5 2 0 0 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 AMD21857.1 - 1.8e-07 31.1 5.5 1.5e-05 24.9 0.1 3.5 3 1 1 4 4 4 2 Region in Clathrin and VPS zf-C3HC4 PF00097.25 AMD21857.1 - 0.0055 16.5 1.3 0.0055 16.5 1.3 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AMD21857.1 - 0.16 11.7 2.6 0.66 9.8 2.6 2.1 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_2 PF13639.6 AMD21857.1 - 0.87 10.0 7.2 0.069 13.5 1.2 2.4 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 AMD21857.1 - 1.2 9.2 4.3 0.42 10.7 0.4 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AMD21857.1 - 1.8 8.5 6.1 0.39 10.6 1.8 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) EF1_GNE PF00736.19 AMD21858.1 - 3.5e-32 110.4 2.1 3.5e-32 110.4 2.1 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 AMD21858.1 - 9.5e-14 51.5 6.2 9.5e-14 51.5 6.2 2.8 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region GST_C PF00043.25 AMD21858.1 - 0.14 12.4 3.3 0.65 10.3 0.4 2.7 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain SNF5 PF04855.12 AMD21859.1 - 1.5e-50 172.2 5.5 1.3e-29 103.7 0.1 2.5 2 1 1 3 3 3 2 SNF5 / SMARCB1 / INI1 CHD5 PF04420.14 AMD21861.1 - 3.7e-35 121.1 1.0 4.9e-35 120.8 1.0 1.1 1 0 0 1 1 1 1 CHD5-like protein GED PF02212.18 AMD21861.1 - 0.00089 19.4 0.3 0.0015 18.6 0.3 1.4 1 0 0 1 1 1 1 Dynamin GTPase effector domain tRNA-synt_1d PF00750.19 AMD21861.1 - 0.008 15.2 0.0 0.0098 14.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) ExbD PF02472.16 AMD21861.1 - 0.016 15.3 0.4 0.024 14.8 0.4 1.3 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR STAR_dimer PF16544.5 AMD21861.1 - 0.034 13.7 2.8 0.067 12.8 2.8 1.5 1 0 0 1 1 1 0 Homodimerisation region of STAR domain protein LRS4 PF10422.9 AMD21861.1 - 0.2 11.2 6.4 0.27 10.8 6.4 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 UCH PF00443.29 AMD21862.1 - 7.6e-64 215.7 0.4 7.6e-64 215.7 0.4 2.2 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD21862.1 - 9.5e-17 61.6 3.2 1.9e-15 57.3 3.1 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 AMD21862.1 - 6.1e-06 26.7 0.0 1.5e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.20 AMD21862.1 - 0.002 17.8 0.7 0.002 17.8 0.7 2.6 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger AAA_7 PF12775.7 AMD21862.1 - 0.089 12.3 0.3 0.21 11.1 0.3 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Y_phosphatase2 PF03162.13 AMD21863.1 - 3.1e-52 176.5 0.3 3.7e-52 176.2 0.3 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Phage_glycop_gL PF11108.8 AMD21863.1 - 0.026 14.6 0.3 0.044 13.8 0.3 1.4 1 0 0 1 1 1 0 Viral glycoprotein L Y_phosphatase3 PF13350.6 AMD21863.1 - 0.075 13.0 0.0 0.076 13.0 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Asp_protease PF09668.10 AMD21864.1 - 7.9e-51 171.0 0.1 1.5e-50 170.1 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 AMD21864.1 - 8.5e-19 67.9 0.3 2e-18 66.7 0.1 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AMD21864.1 - 1.2e-08 35.5 0.1 2.2e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 AMD21864.1 - 2.8e-08 33.5 0.0 1.7e-07 31.0 0.0 2.2 3 0 0 3 3 3 1 UBA/TS-N domain RVP PF00077.20 AMD21864.1 - 9.4e-06 25.9 0.1 2.9e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 AMD21864.1 - 0.0036 17.1 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Peptidase_A2B PF12384.8 AMD21864.1 - 0.023 14.2 0.1 0.088 12.3 0.0 2.0 1 1 1 2 2 2 0 Ty3 transposon peptidase COX15-CtaA PF02628.15 AMD21865.1 - 6.3e-116 387.0 2.4 7.7e-116 386.7 2.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Abhydrolase_9_N PF15420.6 AMD21865.1 - 0.48 10.4 4.5 0.14 12.2 0.2 2.2 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Lon_C PF05362.13 AMD21866.1 - 1.3e-65 220.8 0.0 2.7e-65 219.7 0.0 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 AMD21866.1 - 6.8e-29 101.2 1.3 5.2e-28 98.3 0.1 2.4 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 AMD21866.1 - 2.8e-23 82.8 0.0 1e-22 81.0 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 AMD21866.1 - 1.6e-06 28.4 0.0 4.5e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AMD21866.1 - 8.6e-06 25.8 0.0 3.3e-05 23.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AMD21866.1 - 3.8e-05 24.0 0.2 0.002 18.4 0.2 3.1 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AMD21866.1 - 0.00015 21.6 0.0 0.002 17.9 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain ChlI PF13541.6 AMD21866.1 - 0.00035 20.4 0.0 0.00073 19.4 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase IstB_IS21 PF01695.17 AMD21866.1 - 0.00052 19.8 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_PrkA PF08298.11 AMD21866.1 - 0.00074 18.5 0.0 0.0015 17.5 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_3 PF07726.11 AMD21866.1 - 0.0082 16.0 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AMD21866.1 - 0.012 16.0 0.8 0.045 14.1 0.1 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 AMD21866.1 - 0.014 15.9 0.0 0.086 13.4 0.0 2.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 AMD21866.1 - 0.016 15.2 0.0 0.058 13.4 0.0 2.0 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AMD21866.1 - 0.019 14.9 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase NTPase_1 PF03266.15 AMD21866.1 - 0.049 13.5 2.4 2.1 8.2 0.1 3.0 3 0 0 3 3 3 0 NTPase NACHT PF05729.12 AMD21866.1 - 0.072 13.0 0.0 0.61 10.0 0.0 2.3 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 AMD21866.1 - 0.075 13.4 0.0 0.24 11.8 0.0 2.0 1 0 0 1 1 1 0 RNA helicase SKI PF01202.22 AMD21866.1 - 0.086 13.0 0.9 0.28 11.3 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase NB-ARC PF00931.22 AMD21866.1 - 0.088 12.0 0.1 0.21 10.7 0.1 1.6 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 AMD21866.1 - 0.098 13.2 0.5 0.46 11.0 0.1 2.4 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 AMD21866.1 - 0.1 12.1 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 AMD21866.1 - 0.15 12.1 0.0 0.51 10.4 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CBFD_NFYB_HMF PF00808.23 AMD21867.1 - 7.7e-26 90.2 0.1 1.2e-25 89.5 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AMD21867.1 - 1.1e-05 25.8 0.2 1.5e-05 25.3 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 AMD21867.1 - 0.012 15.6 0.0 0.14 12.2 0.0 2.2 2 0 0 2 2 2 0 Bromodomain associated TFIID_20kDa PF03847.13 AMD21867.1 - 0.016 15.7 0.3 0.091 13.3 0.1 2.2 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A CENP-T_C PF15511.6 AMD21867.1 - 0.026 14.6 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Dynein_heavy PF03028.15 AMD21867.1 - 0.13 12.3 0.1 0.23 11.6 0.1 1.3 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain Rft-1 PF04506.13 AMD21868.1 - 6.9e-200 665.1 35.4 7.8e-200 665.0 35.4 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt PF01943.17 AMD21868.1 - 4.2 6.7 36.7 0.4 10.0 8.7 4.5 2 2 1 3 3 3 0 Polysaccharide biosynthesis protein Exo_endo_phos PF03372.23 AMD21869.1 - 3.4e-14 52.9 0.0 6.1e-14 52.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 AMD21869.1 - 1.2e-07 31.7 2.5 2.3e-07 30.8 2.5 1.5 1 0 0 1 1 1 1 GRF zinc finger Exo_endo_phos_2 PF14529.6 AMD21869.1 - 1e-05 25.4 0.0 0.087 12.7 0.0 2.6 1 1 0 2 2 2 2 Endonuclease-reverse transcriptase Sortilin-Vps10 PF15902.5 AMD21871.1 - 1.4e-181 604.2 14.1 1.2e-133 446.2 3.9 3.3 3 1 0 3 3 3 3 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 AMD21871.1 - 3.9e-51 173.8 14.1 9.2e-36 123.7 2.6 2.5 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 AMD21871.1 - 5.4e-13 46.8 31.6 0.072 13.1 0.2 11.4 11 0 0 11 11 11 7 BNR/Asp-box repeat BNR_2 PF13088.6 AMD21871.1 - 3.7e-06 26.5 0.3 1.2 8.4 0.0 4.7 4 1 0 4 4 4 3 BNR repeat-like domain CHB_HEX_C PF03174.13 AMD21871.1 - 0.0044 17.0 0.2 3.8 7.6 0.0 3.4 2 1 1 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain BNR_6 PF15899.5 AMD21871.1 - 0.0093 15.9 12.4 5.9 7.2 0.2 6.8 7 0 0 7 7 7 2 BNR-Asp box repeat Pkinase PF00069.25 AMD21872.1 - 1.7e-68 230.8 0.0 2.1e-68 230.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21872.1 - 7.5e-32 110.6 0.0 1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD21872.1 - 0.002 17.2 1.2 0.011 14.8 1.2 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 AMD21872.1 - 0.044 13.1 0.4 0.12 11.8 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family AcetylCoA_hydro PF02550.15 AMD21873.1 - 2.1e-59 200.8 0.0 3.4e-59 200.2 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 AMD21873.1 - 1.6e-41 141.8 0.0 3.2e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.12 AMD21873.1 - 0.0037 16.2 0.1 0.015 14.2 0.1 1.8 2 0 0 2 2 2 1 Citrate lyase, alpha subunit (CitF) Acid_PPase PF12689.7 AMD21874.1 - 9.9e-39 132.9 0.0 1.1e-38 132.8 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase DUF2046 PF09755.9 AMD21875.1 - 0.0067 15.7 0.2 0.0092 15.2 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) MerR_2 PF13591.6 AMD21875.1 - 0.12 12.2 0.8 0.22 11.4 0.8 1.4 1 0 0 1 1 1 0 MerR HTH family regulatory protein PRKG1_interact PF15898.5 AMD21875.1 - 0.84 10.6 4.2 0.5 11.3 0.3 2.3 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain Collagen PF01391.18 AMD21876.1 - 5.5e-40 134.9 483.3 0.001 18.8 30.2 23.5 7 5 8 15 15 15 7 Collagen triple helix repeat (20 copies) RRM_1 PF00076.22 AMD21877.1 - 5.3e-40 135.1 0.0 6.8e-19 67.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AMD21877.1 - 0.00021 20.9 0.0 0.06 12.9 0.0 2.5 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD21877.1 - 0.014 15.5 0.1 6.7 6.9 0.1 2.6 2 1 0 2 2 2 0 RNA recognition motif DbpA PF03880.15 AMD21877.1 - 0.04 13.9 0.0 3.5 7.7 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain Prothymosin PF03247.14 AMD21877.1 - 0.17 12.4 48.5 3.2 8.3 25.9 2.3 1 1 1 2 2 2 0 Prothymosin/parathymosin family Arrestin_N PF00339.29 AMD21878.1 - 1.6e-18 67.2 0.0 3.3e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 AMD21878.1 - 6.6e-08 33.1 0.5 7.1e-07 29.8 0.1 2.5 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.15 AMD21878.1 - 0.055 12.5 0.0 0.21 10.6 0.0 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 26 RNase_PH PF01138.21 AMD21879.1 - 8.6e-18 65.1 0.0 1.2e-17 64.7 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PEMT PF04191.13 AMD21880.1 - 3.1e-52 175.4 19.8 2.4e-29 101.8 1.8 3.5 3 1 0 3 3 3 2 Phospholipid methyltransferase HECW_N PF16562.5 AMD21880.1 - 0.00042 20.1 0.1 0.0013 18.5 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 AMD21880.1 - 0.011 16.3 1.0 0.45 11.1 1.0 2.7 1 1 0 1 1 1 0 SKICH domain LrgB PF04172.16 AMD21880.1 - 0.49 9.9 4.8 0.39 10.2 2.5 2.0 1 1 1 2 2 2 0 LrgB-like family Septin PF00735.18 AMD21881.1 - 1.1e-110 369.4 0.8 1.1e-110 369.4 0.8 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 AMD21881.1 - 5e-06 26.6 0.2 5e-06 26.6 0.2 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AMD21881.1 - 6.3e-05 23.4 1.7 0.00016 22.1 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 AMD21881.1 - 0.0038 17.7 2.7 0.087 13.3 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 AMD21881.1 - 0.01 16.1 1.2 0.063 13.6 0.0 2.8 3 1 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 AMD21881.1 - 0.011 15.6 0.0 0.011 15.6 0.0 3.3 4 0 0 4 4 4 0 RsgA GTPase Exonuc_VII_L PF02601.15 AMD21881.1 - 0.016 14.8 11.9 0.03 13.9 11.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lipocalin PF00061.23 AMD21881.1 - 0.018 15.3 1.5 0.049 13.8 1.5 1.7 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family AAA_14 PF13173.6 AMD21881.1 - 0.054 13.5 1.6 0.11 12.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 AMD21881.1 - 0.055 13.0 0.0 0.055 13.0 0.0 3.1 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AMD21881.1 - 0.084 12.9 12.7 0.56 10.2 0.1 3.7 2 2 1 3 3 3 0 Dynamin family AIG1 PF04548.16 AMD21881.1 - 0.11 11.8 7.2 0.71 9.2 0.0 3.0 3 0 0 3 3 3 0 AIG1 family FtsK_SpoIIIE PF01580.18 AMD21881.1 - 0.18 11.2 1.1 0.31 10.4 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Strep_SA_rep PF06696.11 AMD21881.1 - 0.68 10.0 8.6 0.15 12.0 1.6 2.6 2 0 0 2 2 2 0 Streptococcal surface antigen repeat FapA PF03961.13 AMD21881.1 - 1.6 7.2 14.3 2.9 6.4 14.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2852 PF11014.8 AMD21881.1 - 8.7 6.5 8.5 0.76 9.9 2.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) SHNi-TPR PF10516.9 AMD21882.1 - 2.6e-16 58.8 3.3 1e-15 56.9 1.4 3.0 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.6 AMD21882.1 - 0.012 15.8 5.6 0.065 13.5 0.4 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 AMD21882.1 - 0.064 13.2 4.5 0.33 10.9 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 AMD21882.1 - 0.27 11.5 14.2 0.37 11.0 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat NPR3 PF03666.13 AMD21882.1 - 0.3 9.9 13.7 0.47 9.2 13.7 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TPR_8 PF13181.6 AMD21882.1 - 0.43 10.9 4.0 18 5.9 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 AMD21882.1 - 1.5 8.9 4.5 12 6.1 1.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Presenilin PF01080.17 AMD21882.1 - 2.8 6.6 19.2 4.7 5.9 19.2 1.4 1 0 0 1 1 1 0 Presenilin UPF0121 PF03661.13 AMD21883.1 - 9.1e-29 100.5 4.8 1.2e-28 100.1 4.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) ORC4_C PF14629.6 AMD21883.1 - 0.023 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus HSP70 PF00012.20 AMD21884.1 - 1.3e-262 872.4 7.5 1.5e-262 872.2 7.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AMD21884.1 - 5.4e-18 64.9 0.0 8.2e-17 61.0 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 AMD21884.1 - 0.0015 18.3 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 AMD21884.1 - 0.0076 15.5 1.1 0.02 14.2 0.1 2.3 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 AMD21884.1 - 0.05 13.1 0.0 7.9 5.9 0.0 2.3 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DUF3599 PF12206.8 AMD21885.1 - 0.038 14.4 0.0 0.044 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3599) COX6A PF02046.15 AMD21886.1 - 2.6e-37 127.7 0.7 2.9e-37 127.5 0.7 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa WD40 PF00400.32 AMD21887.1 - 2.7e-16 59.6 1.6 0.0017 19.1 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 AMD21887.1 - 0.0037 16.3 1.1 2.8 6.8 0.2 3.2 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_S26e PF01283.19 AMD21888.1 - 6.2e-51 171.4 10.6 7.2e-51 171.2 10.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e COX5B PF01215.19 AMD21889.1 - 1.1e-64 215.9 0.0 1.2e-64 215.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb RabGAP-TBC PF00566.18 AMD21890.1 - 3.1e-05 23.7 5.2 0.016 14.8 0.4 3.1 4 0 0 4 4 4 2 Rab-GTPase-TBC domain WSC PF01822.19 AMD21891.1 - 3.7e-07 30.2 8.8 1.1e-06 28.7 8.8 1.8 1 0 0 1 1 1 1 WSC domain FixS PF03597.15 AMD21891.1 - 0.36 10.6 1.4 0.72 9.6 1.4 1.4 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Stevor PF17410.2 AMD21891.1 - 1.4 8.4 3.5 3.9 6.9 3.5 1.8 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame zf-C2H2 PF00096.26 AMD21892.1 - 2.6e-06 27.6 25.6 0.00015 22.0 3.2 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD21892.1 - 0.00061 20.1 6.8 0.0086 16.5 3.5 3.0 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AMD21892.1 - 0.0015 18.8 1.6 0.0034 17.6 0.3 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AMD21892.1 - 0.0027 18.0 2.2 0.0042 17.4 0.4 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 AMD21892.1 - 0.0042 17.3 4.5 0.012 15.9 4.5 1.8 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 AMD21892.1 - 0.0043 17.0 2.5 0.0083 16.1 0.9 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AMD21892.1 - 0.013 16.3 2.6 0.013 16.3 2.6 4.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 AMD21892.1 - 0.089 12.7 1.3 0.2 11.6 1.3 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type FOXP-CC PF16159.5 AMD21892.1 - 0.2 12.3 17.0 0.24 12.1 1.5 3.9 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2HE PF16278.5 AMD21892.1 - 1.6 9.2 11.3 1.7 9.2 8.1 2.8 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger CLP1_P PF16575.5 AMD21893.1 - 3.1e-26 92.3 0.7 1.4e-24 86.9 0.7 2.9 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 AMD21893.1 - 0.016 15.3 0.0 0.05 13.7 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 AMD21893.1 - 0.018 14.3 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit Arf PF00025.21 AMD21893.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family SRPRB PF09439.10 AMD21893.1 - 0.15 11.5 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA PF00004.29 AMD21894.1 - 7.3e-93 307.9 0.0 4.9e-47 159.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD21894.1 - 1.1e-21 76.4 1.1 7.7e-10 38.4 0.3 3.0 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AMD21894.1 - 4.6e-14 52.5 0.0 1.4e-06 28.2 0.0 3.0 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AMD21894.1 - 4e-13 50.1 0.3 8.5e-05 23.0 0.0 4.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 AMD21894.1 - 4.7e-12 46.4 0.4 0.013 15.8 0.0 5.4 3 2 3 6 6 5 2 AAA domain AAA_2 PF07724.14 AMD21894.1 - 6.9e-11 42.6 0.0 0.00061 20.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 AMD21894.1 - 1.4e-09 38.3 0.0 0.00058 20.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 AMD21894.1 - 4e-09 36.6 0.1 0.0034 17.4 0.0 3.4 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 AMD21894.1 - 8.4e-09 35.1 0.0 0.0003 20.1 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 AMD21894.1 - 2.6e-08 34.0 0.0 0.019 15.0 0.0 3.5 4 0 0 4 4 3 2 AAA domain AAA_18 PF13238.6 AMD21894.1 - 3.1e-08 34.2 0.0 0.00084 19.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 AMD21894.1 - 9.1e-08 32.0 0.1 0.0015 18.5 0.0 3.0 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 AMD21894.1 - 2.8e-07 30.9 0.0 0.017 15.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.27 AMD21894.1 - 5.5e-07 30.2 0.0 0.023 15.2 0.0 2.8 2 0 0 2 2 2 2 ABC transporter Zeta_toxin PF06414.12 AMD21894.1 - 6.8e-07 28.8 0.0 0.044 13.1 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin Rad17 PF03215.15 AMD21894.1 - 2.1e-06 27.8 0.0 0.0094 15.9 0.0 2.6 2 0 0 2 2 2 2 Rad17 P-loop domain IstB_IS21 PF01695.17 AMD21894.1 - 2.4e-06 27.4 0.0 0.045 13.5 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 AMD21894.1 - 3.3e-06 26.6 0.3 0.05 13.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AMD21894.1 - 5.2e-06 26.8 0.0 0.062 13.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 AMD21894.1 - 9.5e-06 25.5 0.0 0.049 13.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 AMD21894.1 - 5.2e-05 23.5 0.0 0.0023 18.1 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family TsaE PF02367.17 AMD21894.1 - 6.1e-05 23.0 0.0 0.48 10.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 AMD21894.1 - 7.3e-05 23.2 1.1 0.14 12.6 0.0 3.4 4 0 0 4 4 2 1 AAA domain SKI PF01202.22 AMD21894.1 - 0.00011 22.3 0.1 0.21 11.7 0.0 3.2 3 0 0 3 3 2 1 Shikimate kinase NACHT PF05729.12 AMD21894.1 - 0.00012 22.1 0.1 0.77 9.7 0.0 3.0 3 0 0 3 3 2 2 NACHT domain AAA_25 PF13481.6 AMD21894.1 - 0.00014 21.5 0.2 1.7 8.2 0.0 3.8 3 1 0 4 4 4 1 AAA domain AAA_7 PF12775.7 AMD21894.1 - 0.0003 20.4 0.0 0.72 9.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Viral_helicase1 PF01443.18 AMD21894.1 - 0.00031 20.6 0.0 0.95 9.1 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 AMD21894.1 - 0.00033 20.4 0.0 0.27 10.9 0.0 3.1 2 1 1 3 3 3 1 Sigma-54 interaction domain DUF815 PF05673.13 AMD21894.1 - 0.00033 19.9 0.0 0.098 11.8 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 AMD21894.1 - 0.0004 20.2 0.1 0.88 9.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain CPT PF07931.12 AMD21894.1 - 0.0011 18.9 0.0 0.025 14.4 0.0 2.4 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein ATPase_2 PF01637.18 AMD21894.1 - 0.0012 18.8 0.0 2.4 8.0 0.0 3.3 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 AMD21894.1 - 0.002 17.3 0.0 1 8.5 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain ATPase PF06745.13 AMD21894.1 - 0.0024 17.3 0.0 1.6 8.0 0.0 3.1 3 0 0 3 3 3 1 KaiC Parvo_NS1 PF01057.17 AMD21894.1 - 0.0028 16.8 0.1 1.9 7.5 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 AMD21894.1 - 0.0045 17.1 0.0 2.8 8.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Cytidylate_kin PF02224.18 AMD21894.1 - 0.0048 16.7 0.7 0.41 10.4 0.0 3.0 3 0 0 3 3 3 1 Cytidylate kinase AAA_11 PF13086.6 AMD21894.1 - 0.0064 16.3 6.5 0.77 9.5 0.0 3.3 3 1 0 3 3 2 2 AAA domain SRPRB PF09439.10 AMD21894.1 - 0.008 15.6 0.0 2.3 7.6 0.0 2.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 AMD21894.1 - 0.011 15.4 0.0 5.5 6.7 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Hydin_ADK PF17213.3 AMD21894.1 - 0.029 14.7 1.7 0.38 11.0 0.0 3.1 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain PhoH PF02562.16 AMD21894.1 - 0.031 13.7 0.2 2.8 7.3 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein DUF3770 PF12603.8 AMD21894.1 - 0.032 13.7 0.5 1.4 8.3 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3770) Phage_Gp17 PF17549.2 AMD21894.1 - 0.035 14.1 0.5 0.11 12.5 0.4 1.9 2 0 0 2 2 1 0 Gene Product 17 AAA_19 PF13245.6 AMD21894.1 - 0.035 14.4 0.0 8.6 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 AMD21894.1 - 0.038 12.9 0.0 9 5.1 0.0 2.5 3 0 0 3 3 2 0 AFG1-like ATPase NTPase_1 PF03266.15 AMD21894.1 - 0.045 13.7 0.0 12 5.7 0.0 2.5 2 0 0 2 2 2 0 NTPase MMR_HSR1 PF01926.23 AMD21894.1 - 0.061 13.4 0.4 3.3 7.8 0.0 3.3 3 0 0 3 3 2 0 50S ribosome-binding GTPase TniB PF05621.11 AMD21894.1 - 0.062 12.7 0.0 18 4.7 0.0 3.0 2 0 0 2 2 2 0 Bacterial TniB protein RsgA_GTPase PF03193.16 AMD21894.1 - 0.068 13.1 0.0 1 9.3 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 AMD21894.1 - 0.074 12.6 0.1 2 7.9 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_23 PF13476.6 AMD21894.1 - 1.2 9.6 0.0 1.2 9.6 0.0 3.2 3 1 0 3 3 2 0 AAA domain KH_dom-like PF14714.6 AMD21895.1 - 0.0013 19.0 0.6 0.0036 17.6 0.6 1.8 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal HALZ PF02183.18 AMD21895.1 - 0.024 14.9 0.5 0.07 13.4 0.3 1.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper YxiJ PF14176.6 AMD21895.1 - 0.28 11.7 4.2 0.49 10.9 2.1 2.4 2 1 1 3 3 3 0 YxiJ-like protein KH_1 PF00013.29 AMD21896.1 - 1.7e-14 53.3 0.1 1.3e-05 24.9 0.1 5.3 5 0 0 5 5 5 4 KH domain MAT1 PF06391.13 AMD21897.1 - 0.011 15.6 8.5 0.011 15.6 8.5 2.2 2 1 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 CCDC66 PF15236.6 AMD21897.1 - 0.21 11.4 27.6 0.024 14.5 19.6 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 UPF0242 PF06785.11 AMD21897.1 - 0.69 10.0 20.1 2.7 8.0 12.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Peptidase_S49_N PF08496.10 AMD21897.1 - 1.2 9.2 10.8 1.3 9.0 6.6 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Striatin PF08232.12 AMD21897.1 - 4.6 7.8 19.2 0.88 10.2 12.6 2.1 2 0 0 2 2 2 0 Striatin family CK1gamma_C PF12605.8 AMD21897.1 - 7.4 7.8 6.4 47 5.2 0.2 2.3 2 0 0 2 2 2 0 Casein kinase 1 gamma C terminal ChaC PF04752.12 AMD21898.1 - 4.2e-49 167.0 0.0 5.6e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein GDI PF00996.18 AMD21899.1 - 4.9e-228 756.9 1.2 5.6e-228 756.7 1.2 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 AMD21899.1 - 0.0084 16.3 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain LSM PF01423.22 AMD21900.1 - 8.1e-18 63.9 0.2 1e-17 63.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AMD21900.1 - 0.031 13.9 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Hfq protein zf-C2H2_10 PF16588.5 AMD21901.1 - 3e-13 49.2 2.8 6e-13 48.3 2.8 1.5 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC_4 PF14392.6 AMD21901.1 - 0.021 14.6 0.4 0.039 13.7 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle DCD PF06559.11 AMD21901.1 - 0.026 13.3 0.0 0.028 13.2 0.0 1.2 1 1 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) zf-CCHC PF00098.23 AMD21901.1 - 0.1 12.7 0.9 0.17 12.0 0.9 1.4 1 0 0 1 1 1 0 Zinc knuckle Baculo_gp41 PF04700.12 AMD21901.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region DUF4709 PF15821.5 AMD21901.1 - 0.14 12.5 3.3 0.19 12.0 3.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4709) UAF_Rrn10 PF05234.11 AMD21902.1 - 1.3e-31 109.3 0.0 1.5e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Gemini_AL1_M PF08283.11 AMD21902.1 - 0.13 12.3 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Geminivirus rep protein central domain Methyltr_RsmB-F PF01189.17 AMD21903.1 - 2.3e-40 138.4 0.0 7.1e-40 136.8 0.0 1.8 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 AMD21903.1 - 0.00023 21.3 0.0 0.00047 20.3 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase MCM PF00493.23 AMD21904.1 - 5e-103 343.0 0.1 7.3e-103 342.5 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AMD21904.1 - 1.7e-36 124.9 0.0 2.9e-36 124.1 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AMD21904.1 - 1.3e-24 86.4 0.1 3.6e-24 85.0 0.1 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 AMD21904.1 - 1.7e-24 86.9 26.9 1.7e-24 86.9 26.9 3.7 4 0 0 4 4 4 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 AMD21904.1 - 2.5e-12 47.3 0.1 7.2e-12 45.8 0.1 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AMD21904.1 - 1.9e-09 37.2 0.0 2e-07 30.6 0.0 2.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AMD21904.1 - 2e-07 31.1 0.0 4.4e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AMD21904.1 - 0.00065 19.6 0.0 0.0028 17.5 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AMD21904.1 - 0.0021 17.8 0.1 0.015 15.0 0.1 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 AMD21904.1 - 0.016 15.7 0.0 0.045 14.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Casc1 PF12366.8 AMD21904.1 - 0.031 13.8 0.1 0.056 13.0 0.1 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 AAA_30 PF13604.6 AMD21904.1 - 0.12 12.1 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain Yippee-Mis18 PF03226.14 AMD21904.1 - 0.13 12.5 0.1 0.31 11.3 0.1 1.6 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-UBR PF02207.20 AMD21905.1 - 6.3e-12 45.5 13.0 6.3e-12 45.5 13.0 2.6 2 1 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) DUF747 PF05346.11 AMD21906.1 - 7.7e-86 288.4 18.3 1.4e-85 287.6 18.3 1.4 1 0 0 1 1 1 1 Eukaryotic membrane protein family RPAP2_Rtr1 PF04181.13 AMD21907.1 - 1.1e-17 64.1 0.7 1.7e-17 63.5 0.7 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family Dicer_dimer PF03368.14 AMD21908.1 - 0.033 14.3 0.5 1.3 9.2 0.2 2.6 2 0 0 2 2 2 0 Dicer dimerisation domain PLDc_2 PF13091.6 AMD21909.1 - 1.9e-14 53.7 0.0 2e-06 27.7 0.0 2.5 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 AMD21909.1 - 7.8e-09 35.4 1.7 0.00042 20.4 0.1 2.9 2 1 0 2 2 2 2 Phospholipase D Active site motif Rer1 PF03248.13 AMD21910.1 - 5.5e-73 244.3 6.4 6.3e-73 244.1 6.4 1.0 1 0 0 1 1 1 1 Rer1 family eRF1_2 PF03464.15 AMD21911.1 - 9.2e-26 90.7 0.2 1.5e-25 90.1 0.2 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 AMD21911.1 - 1.4e-25 90.0 0.2 7.5e-25 87.6 0.0 2.3 2 1 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 AMD21911.1 - 5.5e-21 74.9 0.5 8.1e-21 74.4 0.5 1.3 1 0 0 1 1 1 1 eRF1 domain 1 Septin PF00735.18 AMD21912.1 - 6.8e-106 353.7 2.6 8e-106 353.4 2.6 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AMD21912.1 - 2.7e-10 40.3 0.2 4.9e-10 39.5 0.2 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AMD21912.1 - 2.9e-08 33.5 0.9 3.7e-06 26.6 0.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 AMD21912.1 - 1.3e-06 27.9 0.6 4.2e-06 26.2 0.6 1.9 1 1 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 AMD21912.1 - 2.3e-06 27.6 0.4 1.2e-05 25.3 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 AMD21912.1 - 2.7e-05 24.3 1.5 0.031 14.3 0.6 2.5 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.6 AMD21912.1 - 0.00059 20.3 0.0 0.0014 19.1 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AMD21912.1 - 0.0026 18.0 0.1 0.0068 16.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AMD21912.1 - 0.0032 18.0 1.0 0.0072 16.9 1.0 1.7 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 AMD21912.1 - 0.005 16.5 0.0 0.041 13.6 0.0 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain NB-ARC PF00931.22 AMD21912.1 - 0.0057 15.9 0.2 0.01 15.0 0.2 1.5 1 1 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 AMD21912.1 - 0.008 16.4 0.4 0.1 12.8 1.1 2.6 2 1 0 2 2 2 1 AAA domain IIGP PF05049.13 AMD21912.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) FtsK_SpoIIIE PF01580.18 AMD21912.1 - 0.017 14.4 0.1 0.036 13.4 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Roc PF08477.13 AMD21912.1 - 0.027 14.7 0.0 0.058 13.6 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 AMD21912.1 - 0.029 13.9 0.5 0.07 12.6 0.1 1.9 2 1 1 3 3 3 0 P-loop containing dynein motor region AAA_23 PF13476.6 AMD21912.1 - 0.03 14.8 0.6 0.051 14.1 0.5 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AMD21912.1 - 0.038 13.7 1.4 0.29 10.8 1.4 2.4 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AMD21912.1 - 0.049 13.2 0.0 0.084 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 AMD21912.1 - 0.081 13.0 0.2 0.28 11.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AMD21912.1 - 0.091 13.2 0.1 0.25 11.8 0.0 1.8 2 0 0 2 2 1 0 RNA helicase PduV-EutP PF10662.9 AMD21912.1 - 0.11 12.2 0.1 1.1 9.0 0.1 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Ribosomal_L32p PF01783.23 AMD21913.1 - 3.8e-13 49.5 6.5 3.8e-13 49.5 6.5 1.7 2 0 0 2 2 2 1 Ribosomal L32p protein family Rubredoxin_2 PF18073.1 AMD21913.1 - 0.075 12.8 0.1 0.075 12.8 0.1 1.5 2 0 0 2 2 2 0 Rubredoxin metal binding domain RecR PF02132.15 AMD21913.1 - 0.22 11.1 0.7 0.52 9.9 0.7 1.6 1 0 0 1 1 1 0 RecR protein Cupin_8 PF13621.6 AMD21914.1 - 3.4e-13 49.9 0.2 7e-13 48.9 0.2 1.4 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 AMD21914.1 - 3.5e-10 40.3 0.1 1.9e-09 38.0 0.1 2.3 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 AMD21914.1 - 1.7e-05 24.6 0.1 5.6e-05 23.0 0.1 2.0 1 0 0 1 1 1 1 F-box-like Cupin_2 PF07883.11 AMD21914.1 - 0.0039 16.9 0.0 0.025 14.3 0.0 2.2 2 0 0 2 2 2 1 Cupin domain Ets PF00178.22 AMD21914.1 - 0.088 13.3 0.2 0.49 10.9 0.1 2.4 2 0 0 2 2 2 0 Ets-domain Citrate_synt PF00285.21 AMD21915.1 - 1.4e-99 333.6 0.0 1.7e-99 333.3 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF2802 PF10975.8 AMD21916.1 - 0.064 13.4 1.1 0.19 11.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) SH3BGR PF04908.15 AMD21917.1 - 5.6e-05 23.2 0.0 0.00031 20.9 0.0 2.2 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 AMD21917.1 - 9.2e-05 22.6 0.0 0.00021 21.4 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin hnRNP_Q_AcD PF18360.1 AMD21917.1 - 0.055 13.4 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain DUF3533 PF12051.8 AMD21917.1 - 0.25 10.2 0.4 0.4 9.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) RskA PF10099.9 AMD21918.1 - 0.034 14.4 9.9 0.068 13.5 9.9 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA NPR1_interact PF15699.5 AMD21918.1 - 0.29 11.8 2.1 0.65 10.6 2.1 1.6 1 0 0 1 1 1 0 NPR1 interacting NINJA_B PF16136.5 AMD21918.1 - 3.2 8.2 8.9 0.55 10.6 4.0 2.4 2 0 0 2 2 2 0 Putative nuclear localisation signal DUF3347 PF11827.8 AMD21918.1 - 3.6 7.7 7.7 5.1 7.2 7.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) Glycogen_syn PF05693.13 AMD21919.1 - 0 1081.9 0.0 0 1081.7 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 AMD21919.1 - 9.6e-09 35.0 0.0 7.8e-06 25.5 0.0 2.6 2 1 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AMD21919.1 - 8.7e-08 32.7 0.0 0.00034 21.1 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AMD21919.1 - 9.1e-05 22.5 0.8 0.00092 19.3 0.2 2.4 1 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 AMD21919.1 - 0.00013 21.8 0.4 0.00025 20.8 0.4 1.4 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 AMD21919.1 - 0.00039 20.9 2.0 0.00071 20.1 1.2 2.0 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Phage_hub_GP28 PF11110.8 AMD21919.1 - 0.006 16.5 0.1 0.016 15.1 0.0 1.7 2 0 0 2 2 2 1 Baseplate hub distal subunit Pkinase PF00069.25 AMD21920.1 - 1.4e-73 247.5 0.0 2.2e-73 246.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD21920.1 - 6.1e-43 147.0 0.0 1.6e-42 145.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD21920.1 - 1.4e-05 24.6 0.0 0.0028 17.0 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AMD21920.1 - 4.9e-05 22.3 0.3 0.00036 19.4 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AMD21920.1 - 0.0043 16.4 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family bZIP_2 PF07716.15 AMD21921.1 - 5.4e-08 32.8 11.7 5.4e-08 32.8 11.7 3.2 1 1 2 3 3 3 2 Basic region leucine zipper bZIP_1 PF00170.21 AMD21921.1 - 0.0034 17.5 11.8 0.0034 17.5 11.8 3.1 2 1 1 3 3 3 2 bZIP transcription factor OmpH PF03938.14 AMD21921.1 - 0.027 14.8 8.7 0.5 10.7 7.5 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Tht1 PF04163.12 AMD21921.1 - 0.035 12.9 1.7 0.059 12.1 0.3 1.8 2 0 0 2 2 2 0 Tht1-like nuclear fusion protein SlyX PF04102.12 AMD21921.1 - 0.28 11.8 3.6 0.2 12.3 0.9 2.3 2 1 0 2 2 2 0 SlyX bZIP_Maf PF03131.17 AMD21921.1 - 0.93 10.1 17.1 0.31 11.6 12.9 2.2 1 1 1 2 2 2 0 bZIP Maf transcription factor YabA PF06156.13 AMD21921.1 - 3.7 8.2 9.0 2.3 8.9 5.4 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Proteasome PF00227.26 AMD21923.1 - 2.8e-57 193.3 0.0 3.7e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AMD21923.1 - 1.6e-12 46.9 0.1 4.2e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature TOM13 PF08219.11 AMD21924.1 - 5.5e-23 80.7 0.1 9.7e-23 80.0 0.1 1.5 1 0 0 1 1 1 1 Outer membrane protein TOM13 Rpr2 PF04032.16 AMD21925.1 - 1.2e-18 67.2 0.9 2e-18 66.4 0.9 1.4 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-CDGSH PF09360.10 AMD21925.1 - 0.0015 18.7 0.1 0.0034 17.6 0.1 1.6 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type zf-CSL PF05207.13 AMD21925.1 - 0.064 13.0 0.2 0.13 12.0 0.2 1.5 1 0 0 1 1 1 0 CSL zinc finger LETM1 PF07766.13 AMD21927.1 - 6.1e-96 320.9 5.1 1.1e-95 320.0 5.1 1.5 1 0 0 1 1 1 1 LETM1-like protein Cellulase PF00150.18 AMD21928.1 - 4.1e-12 46.1 0.0 7.4e-07 28.9 0.1 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 AMD21928.1 - 4.5e-12 46.3 0.1 1e-11 45.2 0.1 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain DNA_primase_S PF01896.19 AMD21929.1 - 2.7e-65 219.7 0.7 3.6e-65 219.3 0.7 1.2 1 0 0 1 1 1 1 DNA primase small subunit Proteasome PF00227.26 AMD21930.1 - 1.8e-39 135.2 0.0 2e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit HA2 PF04408.23 AMD21931.1 - 1.6e-24 86.2 0.0 6.3e-24 84.3 0.0 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AMD21931.1 - 3e-16 59.5 0.0 6.7e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.23 AMD21931.1 - 1.6e-14 54.0 0.2 3.8e-14 52.8 0.2 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.31 AMD21931.1 - 4e-14 52.9 0.0 2.4e-13 50.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AMD21931.1 - 1e-05 25.4 0.1 3e-05 23.9 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AMD21931.1 - 2.2e-05 24.7 0.3 0.00011 22.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AMD21931.1 - 0.00015 21.6 0.1 0.00028 20.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD21931.1 - 0.0037 17.6 0.1 0.0096 16.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AMD21931.1 - 0.0056 17.2 5.4 0.063 13.8 0.5 3.4 2 1 0 2 2 2 1 ABC transporter AAA_14 PF13173.6 AMD21931.1 - 0.0073 16.3 0.6 0.13 12.3 0.1 3.0 2 1 0 2 2 2 1 AAA domain ATPase PF06745.13 AMD21931.1 - 0.012 14.9 0.1 0.24 10.7 0.0 2.4 2 0 0 2 2 2 0 KaiC T2SSE PF00437.20 AMD21931.1 - 0.018 14.1 0.0 0.077 12.0 0.0 2.0 3 0 0 3 3 3 0 Type II/IV secretion system protein SRP54 PF00448.22 AMD21931.1 - 0.03 13.9 0.1 0.1 12.2 0.1 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain PWI PF01480.17 AMD21931.1 - 0.057 13.7 0.5 0.5 10.7 0.3 2.5 2 0 0 2 2 2 0 PWI domain THUMP PF02926.17 AMD21931.1 - 0.073 13.2 1.2 0.39 10.8 0.6 2.3 2 0 0 2 2 2 0 THUMP domain AAA_24 PF13479.6 AMD21931.1 - 0.11 12.2 0.2 1.1 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Amino_oxidase PF01593.24 AMD21932.1 - 1.5e-13 50.9 0.0 2e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AMD21932.1 - 1.3e-10 41.3 0.0 6.8e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AMD21932.1 - 4.1e-06 26.6 0.0 7.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 AMD21932.1 - 2.2e-05 23.8 0.1 0.00011 21.5 0.0 2.0 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 AMD21932.1 - 0.00082 19.9 0.0 0.017 15.7 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Beta_helix PF13229.6 AMD21932.1 - 0.0086 15.9 1.1 0.0086 15.9 1.1 2.0 3 0 0 3 3 3 1 Right handed beta helix region Pyr_redox_2 PF07992.14 AMD21932.1 - 0.014 14.7 0.0 0.029 13.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 AMD21932.1 - 0.038 12.6 0.0 0.064 11.8 0.0 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) DUF4950 PF16308.5 AMD21932.1 - 0.051 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4950) RRM_5 PF13893.6 AMD21933.1 - 2e-10 40.3 0.0 2.5e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 AMD21933.1 - 2.7e-09 36.7 0.1 4.5e-09 36.0 0.1 1.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 AMD21933.1 - 0.0014 18.7 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 Limkain b1 RRM_occluded PF16842.5 AMD21933.1 - 0.026 14.4 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Ubiquitin_2 PF14560.6 AMD21933.1 - 0.047 14.1 0.0 0.066 13.7 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain EB1 PF03271.17 AMD21934.1 - 6.9e-16 58.2 0.5 1.6e-15 57.0 0.5 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 AMD21934.1 - 0.00015 21.9 1.5 0.00018 21.6 0.5 1.7 2 0 0 2 2 2 1 Calponin homology (CH) domain SlyX PF04102.12 AMD21934.1 - 0.0093 16.6 0.8 0.023 15.3 0.8 1.7 1 0 0 1 1 1 1 SlyX HR1 PF02185.16 AMD21934.1 - 0.011 15.8 0.5 0.029 14.5 0.5 1.7 1 0 0 1 1 1 0 Hr1 repeat CH_2 PF06294.11 AMD21934.1 - 0.081 13.0 0.1 0.21 11.8 0.0 1.8 1 1 0 1 1 1 0 CH-like domain in sperm protein Uds1 PF15456.6 AMD21934.1 - 0.35 11.0 5.6 0.068 13.3 2.0 1.8 2 1 0 2 2 2 0 Up-regulated During Septation zf-C4H2 PF10146.9 AMD21934.1 - 3.3 8.0 6.1 0.42 10.9 0.9 1.9 1 1 1 2 2 2 0 Zinc finger-containing protein Peptidase_M41 PF01434.18 AMD21935.1 - 1.3e-66 224.1 0.0 1.9e-66 223.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AMD21935.1 - 1.8e-41 141.7 0.0 5.2e-41 140.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD21935.1 - 1.6e-12 47.0 0.0 4.4e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 AMD21935.1 - 0.0053 16.8 0.0 0.022 14.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 AMD21935.1 - 0.0055 16.4 0.0 0.018 14.8 0.0 1.9 1 1 0 1 1 1 1 IstB-like ATP binding protein FtsH_ext PF06480.15 AMD21935.1 - 0.0082 16.5 0.0 0.027 14.8 0.0 1.9 1 0 0 1 1 1 1 FtsH Extracellular TIP49 PF06068.13 AMD21935.1 - 0.0085 15.3 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 AMD21935.1 - 0.015 15.7 0.3 0.07 13.5 0.1 2.3 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 AMD21935.1 - 0.02 15.1 0.6 0.45 10.8 0.1 2.7 2 1 1 3 3 3 0 AAA domain RuvB_N PF05496.12 AMD21935.1 - 0.022 14.5 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AMD21935.1 - 0.069 13.3 0.0 0.27 11.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 AMD21935.1 - 0.2 11.0 0.1 0.41 10.0 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI HMG_box PF00505.19 AMD21936.1 - 1.2e-13 51.2 6.1 1.9e-12 47.4 6.1 2.2 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AMD21936.1 - 2e-05 25.1 2.2 5.1e-05 23.8 2.2 1.7 1 1 0 1 1 1 1 HMG-box domain Ribosomal_S5_C PF03719.15 AMD21937.1 - 8e-24 82.9 0.0 1.4e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 AMD21937.1 - 8.2e-24 83.4 0.1 1.3e-23 82.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain SURF1 PF02104.15 AMD21938.1 - 1.4e-41 142.7 0.1 2e-41 142.2 0.1 1.1 1 0 0 1 1 1 1 SURF1 family Ig_3 PF13927.6 AMD21938.1 - 0.0036 17.9 0.0 0.011 16.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 AMD21938.1 - 0.036 14.2 0.0 0.083 13.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain DUF5634 PF18681.1 AMD21938.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5634) Ig_2 PF13895.6 AMD21938.1 - 0.13 12.6 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain DASH_Dam1 PF08653.10 AMD21939.1 - 7.7e-27 92.9 1.1 2.5e-26 91.3 0.9 1.9 2 0 0 2 2 2 1 DASH complex subunit Dam1 Ctr PF04145.15 AMD21940.1 - 3.8e-22 79.5 3.0 4.1e-22 79.4 1.5 1.7 2 0 0 2 2 2 1 Ctr copper transporter family SH2_2 PF14633.6 AMD21941.1 - 5.5e-69 231.9 2.4 5.5e-69 231.9 2.4 2.0 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.6 AMD21941.1 - 8.5e-59 197.7 0.2 3.4e-58 195.7 0.2 2.1 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 AMD21941.1 - 8e-42 141.8 0.1 3.3e-41 139.8 0.1 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 AMD21941.1 - 7.2e-34 116.7 1.4 7.2e-34 116.7 1.4 2.8 3 0 0 3 3 3 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 AMD21941.1 - 8e-20 71.2 17.8 8e-20 71.2 17.8 4.5 3 1 1 4 4 4 1 Acidic N-terminal SPT6 SH2 PF00017.24 AMD21941.1 - 3.9e-12 46.1 0.0 1.4e-11 44.3 0.0 2.1 1 0 0 1 1 1 1 SH2 domain Tex_YqgF PF16921.5 AMD21941.1 - 7.3e-05 23.2 0.0 0.00024 21.6 0.0 1.9 1 0 0 1 1 1 1 Tex protein YqgF-like domain HHH_9 PF17674.1 AMD21941.1 - 0.00062 20.6 0.1 0.00062 20.6 0.1 4.8 5 0 0 5 5 5 1 HHH domain Formyl_trans_N PF00551.19 AMD21941.1 - 0.12 12.1 0.1 0.3 10.8 0.1 1.6 1 0 0 1 1 1 0 Formyl transferase RGS PF00615.19 AMD21941.1 - 0.16 12.2 8.1 0.032 14.5 2.3 2.9 3 0 0 3 3 3 0 Regulator of G protein signaling domain LETM1 PF07766.13 AMD21942.1 - 1.2e-98 329.8 2.4 1.2e-98 329.8 2.4 1.8 2 0 0 2 2 2 1 LETM1-like protein RRP14 PF15459.6 AMD21942.1 - 0.27 11.9 0.2 0.27 11.9 0.2 3.1 3 0 0 3 3 3 0 60S ribosome biogenesis protein Rrp14 tRNA-synt_1 PF00133.22 AMD21943.1 - 7e-231 767.7 0.0 7e-231 767.7 0.0 2.4 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AMD21943.1 - 3.7e-32 111.4 1.9 3.7e-32 111.4 1.9 2.6 3 0 0 3 3 3 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AMD21943.1 - 1.6e-15 56.7 0.2 1.4e-08 33.9 0.1 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 AMD21943.1 - 8.1e-09 35.3 0.0 3.3e-07 30.0 0.0 4.0 4 1 1 5 5 5 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 AMD21943.1 - 0.22 10.8 7.6 1.1 8.6 0.0 3.4 4 1 0 4 4 4 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.21 AMD21943.1 - 6.4 5.6 9.1 0.94 8.3 0.0 3.1 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain DASH_Spc19 PF08287.11 AMD21943.1 - 8.6 6.2 16.4 12 5.7 5.8 2.6 2 0 0 2 2 2 0 Spc19 RNase_PH PF01138.21 AMD21944.1 - 9.8e-15 55.2 0.0 1.7e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AMD21944.1 - 0.00033 20.6 0.1 0.00053 20.0 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Mito_carr PF00153.27 AMD21945.1 - 9.6e-60 198.5 4.5 4.7e-23 80.9 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Romo1 PF10247.9 AMD21945.1 - 0.014 15.8 0.3 0.85 10.0 0.1 2.7 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 ABC2_membrane_5 PF13346.6 AMD21945.1 - 0.048 13.2 2.6 0.5 9.9 0.0 2.3 2 0 0 2 2 2 0 ABC-2 family transporter protein CDP-OH_P_transf PF01066.21 AMD21946.1 - 1.8e-12 47.8 0.1 1.8e-12 47.8 0.1 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CBF PF03914.17 AMD21947.1 - 1.3e-34 119.6 0.3 2.2e-34 118.9 0.3 1.4 1 0 0 1 1 1 1 CBF/Mak21 family Asn_synthase PF00733.21 AMD21948.1 - 9.2e-95 318.3 0.5 6.8e-55 187.2 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AMD21948.1 - 6.7e-34 116.4 0.0 1.1e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AMD21948.1 - 1.7e-27 96.3 0.0 3e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 AMD21948.1 - 0.0033 16.9 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 AMD21948.1 - 0.0074 15.4 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 NAD synthase GTP_cyclohydroI PF01227.22 AMD21949.1 - 4.7e-74 247.7 0.3 5.7e-74 247.4 0.3 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 AMD21949.1 - 0.00043 20.4 0.0 0.0012 18.9 0.0 1.8 1 0 0 1 1 1 1 QueF-like protein DnaJ_CXXCXGXG PF00684.19 AMD21950.1 - 0.00034 20.9 8.9 0.0045 17.3 1.1 2.4 2 0 0 2 2 2 2 DnaJ central domain Zn-ribbon_8 PF09723.10 AMD21950.1 - 0.052 13.7 0.7 0.052 13.7 0.7 3.0 2 1 1 3 3 3 0 Zinc ribbon domain HypA PF01155.19 AMD21950.1 - 0.06 13.4 1.3 2.9 8.0 0.1 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_3 PF13920.6 AMD21950.1 - 1.5 8.8 6.0 6 6.8 1.0 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD21950.1 - 2.7 7.9 7.9 11 6.0 0.4 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Got1 PF04178.12 AMD21951.1 - 2.9e-14 53.4 15.9 3.8e-14 53.1 15.9 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF373 PF04123.13 AMD21951.1 - 0.59 9.5 5.1 0.49 9.8 3.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF4401 PF14351.6 AMD21951.1 - 0.86 8.9 15.0 2.3 7.5 15.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4401) DUF3784 PF12650.7 AMD21951.1 - 4.2 7.6 12.6 0.16 12.2 0.8 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3784) DUF202 PF02656.15 AMD21951.1 - 6.6 7.3 10.3 6.9e+02 0.8 10.3 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF202) AAA PF00004.29 AMD21952.1 - 4.4e-51 172.7 0.1 2.5e-42 144.4 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD21952.1 - 6.4e-10 38.7 0.0 1.8e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 AMD21952.1 - 1.3e-08 35.2 0.6 3.4e-05 24.0 0.0 3.9 4 0 0 4 4 4 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AMD21952.1 - 1.3e-06 28.9 0.6 0.00021 21.7 0.1 3.8 3 1 0 3 3 3 1 AAA ATPase domain IstB_IS21 PF01695.17 AMD21952.1 - 2.8e-06 27.2 0.0 8.8e-05 22.3 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 AMD21952.1 - 7e-06 26.2 0.2 0.076 13.1 0.0 2.8 3 0 0 3 3 2 2 Sigma-54 interaction domain AAA_5 PF07728.14 AMD21952.1 - 4e-05 23.6 0.0 0.00032 20.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 AMD21952.1 - 5.6e-05 22.9 0.0 0.52 10.0 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain ResIII PF04851.15 AMD21952.1 - 0.00039 20.5 0.0 0.0031 17.5 0.0 2.6 3 0 0 3 3 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 AMD21952.1 - 0.0022 17.1 0.0 0.27 10.2 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein TIP49 PF06068.13 AMD21952.1 - 0.0045 16.2 0.0 0.034 13.4 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_7 PF12775.7 AMD21952.1 - 0.0058 16.2 0.0 0.12 11.9 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 AMD21952.1 - 0.0084 16.6 0.0 0.3 11.6 0.0 3.3 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 AMD21952.1 - 0.01 15.9 0.0 0.054 13.5 0.0 2.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AMD21952.1 - 0.013 16.0 2.5 0.041 14.4 0.0 3.1 3 0 0 3 3 3 0 ABC transporter AAA_22 PF13401.6 AMD21952.1 - 0.013 15.7 0.2 0.17 12.2 0.2 2.7 1 1 0 1 1 1 0 AAA domain Bromodomain PF00439.25 AMD21952.1 - 0.014 15.4 0.2 0.06 13.4 0.0 2.1 2 0 0 2 2 1 0 Bromodomain RNA_helicase PF00910.22 AMD21952.1 - 0.015 15.7 0.0 0.051 14.0 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.17 AMD21952.1 - 0.017 14.2 0.0 0.59 9.2 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_33 PF13671.6 AMD21952.1 - 0.021 15.0 0.0 0.069 13.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 AMD21952.1 - 0.023 14.1 0.0 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 AMD21952.1 - 0.042 13.3 0.0 0.18 11.2 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein RuvB_N PF05496.12 AMD21952.1 - 0.042 13.6 0.0 0.14 11.9 0.0 1.8 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 AMD21952.1 - 0.049 13.5 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AMD21952.1 - 0.057 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AMD21952.1 - 0.065 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 AMD21952.1 - 0.46 10.2 0.0 0.46 10.2 0.0 3.6 4 1 0 4 4 4 0 AAA domain Amidase PF01425.21 AMD21953.1 - 1.4e-121 406.7 0.0 1.7e-121 406.4 0.0 1.0 1 0 0 1 1 1 1 Amidase Dynamitin PF04912.14 AMD21954.1 - 5.2e-29 101.8 19.6 1.6e-22 80.4 10.7 2.1 1 1 1 2 2 2 2 Dynamitin Laminin_II PF06009.12 AMD21954.1 - 0.0033 17.4 1.5 0.0033 17.4 1.5 4.0 3 1 1 4 4 4 2 Laminin Domain II Latarcin PF10279.9 AMD21954.1 - 0.0075 16.7 0.1 4.9 7.6 0.8 3.6 2 2 0 2 2 2 1 Latarcin precursor Glyco_hydro_42C PF08533.10 AMD21954.1 - 0.13 12.0 0.0 0.36 10.6 0.0 1.7 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain SesA PF17107.5 AMD21954.1 - 0.17 12.0 8.5 0.39 10.9 0.4 3.1 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1664 PF07889.12 AMD21954.1 - 0.72 9.9 12.6 0.69 10.0 0.2 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 AMD21954.1 - 0.73 9.6 15.2 3.8 7.3 1.8 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF724) YtxH PF12732.7 AMD21954.1 - 1.4 9.5 5.9 9.1 6.9 0.1 3.7 3 1 0 3 3 3 0 YtxH-like protein Fib_alpha PF08702.10 AMD21954.1 - 4.9 7.3 25.4 0.039 14.1 2.9 3.8 2 1 0 4 4 4 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 AMD21954.1 - 5.8 7.0 9.1 1.8 8.6 0.3 3.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec63 PF02889.16 AMD21955.1 - 4e-121 403.1 0.6 2.4e-77 259.6 0.0 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 AMD21955.1 - 6.8e-50 169.2 2.4 2.9e-24 85.8 0.8 4.0 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 AMD21955.1 - 3.3e-30 105.3 0.5 9.8e-16 58.2 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AMD21955.1 - 3.8e-22 78.7 0.1 3.3e-09 37.1 0.0 4.1 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA PF00004.29 AMD21955.1 - 2.6e-05 24.7 1.6 0.11 13.0 0.0 3.9 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 AMD21955.1 - 7.5e-05 22.3 0.1 0.073 12.5 0.0 3.2 3 0 0 3 3 3 2 PhoH-like protein AAA_22 PF13401.6 AMD21955.1 - 0.00018 21.8 5.8 0.18 12.1 0.1 4.7 3 2 0 3 3 3 2 AAA domain AAA_19 PF13245.6 AMD21955.1 - 0.00047 20.5 0.7 0.064 13.6 0.4 2.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AMD21955.1 - 0.003 17.3 0.3 1.2 8.8 0.0 3.7 4 0 0 4 4 4 1 IstB-like ATP binding protein T2SSE PF00437.20 AMD21955.1 - 0.013 14.6 0.0 4.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Helicase_PWI PF18149.1 AMD21955.1 - 0.018 15.2 0.1 0.062 13.5 0.1 1.9 1 0 0 1 1 1 0 N-terminal helicase PWI domain TniB PF05621.11 AMD21955.1 - 0.38 10.1 3.0 22 4.4 0.3 3.6 2 1 0 3 3 3 0 Bacterial TniB protein Efg1 PF10153.9 AMD21956.1 - 3e-32 111.4 10.3 5.8e-32 110.4 10.3 1.5 1 0 0 1 1 1 1 rRNA-processing protein Efg1 efb-c PF12199.8 AMD21956.1 - 0.049 13.7 0.9 0.16 12.0 0.9 1.9 1 0 0 1 1 1 0 Extracellular fibrinogen binding protein C terminal Tox-HNH-HHH PF15637.6 AMD21956.1 - 0.093 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Phage_tail_APC PF16778.5 AMD21956.1 - 0.11 12.4 0.6 0.32 10.9 0.6 1.9 1 1 0 1 1 1 0 Phage tail assembly chaperone protein DUF2406 PF10295.9 AMD21957.1 - 6.4e-28 97.2 0.3 1.1e-27 96.4 0.3 1.4 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) Aminotran_1_2 PF00155.21 AMD21958.1 - 7.9e-62 209.5 0.1 9.6e-62 209.2 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_S10 PF00450.22 AMD21959.1 - 2.2e-131 439.1 0.3 2.6e-131 438.9 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 AMD21959.1 - 0.00012 22.6 0.4 0.00027 21.5 0.4 1.7 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide DUF3591 PF12157.8 AMD21961.1 - 1.5e-175 584.1 1.8 3.2e-175 583.1 1.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 AMD21961.1 - 9.2e-08 31.8 0.9 2.4e-07 30.5 0.9 1.6 1 0 0 1 1 1 1 Zinc knuckle SAP30_Sin3_bdg PF13867.6 AMD21961.1 - 0.068 13.5 0.1 0.22 11.9 0.1 1.9 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Rtt102p PF09510.10 AMD21962.1 - 1.4e-20 73.9 7.8 1.8e-20 73.5 0.6 2.9 2 1 0 2 2 2 1 Rtt102p-like transcription regulator protein RNase_T PF00929.24 AMD21963.1 - 1.7e-07 31.9 0.1 5.1e-07 30.4 0.0 1.9 1 1 1 2 2 2 1 Exonuclease DUF3682 PF12446.8 AMD21963.1 - 0.11 12.9 3.8 0.29 11.6 3.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) GATase_6 PF13522.6 AMD21965.1 - 1.7e-14 54.2 0.0 4.3e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AMD21965.1 - 6.3e-13 48.7 0.0 1.3e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 AMD21965.1 - 9.4e-09 35.0 0.1 1.6e-08 34.2 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 AMD21965.1 - 0.0017 17.3 0.0 0.0029 16.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Pribosyl_synth PF14572.6 AMD21965.1 - 0.12 12.3 0.2 0.28 11.2 0.2 1.6 1 1 0 1 1 1 0 Phosphoribosyl synthetase-associated domain ABC_membrane PF00664.23 AMD21966.1 - 9.5e-43 146.8 18.2 1.3e-42 146.3 18.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AMD21966.1 - 3.3e-35 121.6 0.4 8.2e-35 120.3 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 AMD21966.1 - 4.6e-10 39.3 0.1 6.7e-07 29.0 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AMD21966.1 - 0.0019 17.9 0.2 0.0053 16.5 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 AMD21966.1 - 0.0092 16.4 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 AMD21966.1 - 0.016 14.1 0.7 0.096 11.5 0.1 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class MMR_HSR1 PF01926.23 AMD21966.1 - 0.028 14.5 0.1 0.066 13.3 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF815 PF05673.13 AMD21966.1 - 0.031 13.4 0.1 0.07 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 AMD21966.1 - 0.051 13.9 0.0 0.12 12.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AMD21966.1 - 0.11 12.9 0.1 0.11 12.9 0.1 2.2 2 1 0 2 2 2 0 AAA domain MoeA_C PF03454.15 AMD21966.1 - 0.12 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 MoeA C-terminal region (domain IV) AAA_30 PF13604.6 AMD21966.1 - 0.15 11.7 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Proteasome PF00227.26 AMD21967.1 - 2.1e-47 161.1 0.1 2.5e-47 160.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AMD21967.1 - 6.7e-12 44.9 0.1 1.3e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF3336 PF11815.8 AMD21968.1 - 3.6e-25 88.3 0.0 6.4e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 AMD21968.1 - 3.9e-07 30.4 0.0 8.1e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase RAC_head PF16717.5 AMD21970.1 - 3.6e-20 72.8 4.6 3.6e-20 72.8 4.6 3.0 2 1 0 2 2 2 1 Ribosome-associated complex head domain DnaJ PF00226.31 AMD21970.1 - 3.2e-15 56.0 0.2 8.6e-15 54.6 0.2 1.8 1 0 0 1 1 1 1 DnaJ domain SURF4 PF02077.15 AMD21971.1 - 4.7e-96 321.5 12.3 5.4e-96 321.3 12.3 1.0 1 0 0 1 1 1 1 SURF4 family MerC PF03203.14 AMD21971.1 - 2.8 8.4 12.7 0.48 10.9 2.5 2.3 2 0 0 2 2 2 0 MerC mercury resistance protein IPP-2 PF04979.14 AMD21972.1 - 4.4e-18 66.3 6.9 4.4e-18 66.3 6.9 1.8 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) HPIP PF15226.6 AMD21972.1 - 0.051 14.0 0.0 0.078 13.4 0.0 1.3 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family Methyltrn_RNA_3 PF02598.17 AMD21973.1 - 1.5e-68 231.4 0.0 1.8e-68 231.1 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase Plasmid_stab_B PF10784.9 AMD21973.1 - 0.078 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Plasmid stability protein CC PF04942.14 AMD21973.1 - 0.17 12.1 0.5 0.33 11.2 0.5 1.4 1 0 0 1 1 1 0 CC domain Glyco_hydro_17 PF00332.18 AMD21974.1 - 5e-73 246.4 0.1 5.7e-73 246.2 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 DUF1663 PF07909.11 AMD21974.1 - 0.12 11.0 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1663) eIF-3c_N PF05470.12 AMD21975.1 - 2.7e-153 511.4 16.7 7.4e-120 401.0 3.1 2.8 3 1 1 4 4 4 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 AMD21975.1 - 1.3e-10 41.8 0.7 7.6e-09 36.0 0.3 4.0 4 1 0 4 4 4 1 PCI domain AAA_lid_4 PF17864.1 AMD21975.1 - 0.037 13.8 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 RuvB AAA lid domain TPR_18 PF13512.6 AMD21975.1 - 0.072 13.2 0.5 0.39 10.8 0.0 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat SURF2 PF05477.11 AMD21975.1 - 2 8.0 8.7 5.4 6.6 8.7 1.7 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) CENP-B_dimeris PF09026.10 AMD21976.1 - 0.014 15.8 0.4 0.045 14.1 0.4 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Otopetrin PF03189.13 AMD21976.1 - 0.076 11.8 6.8 0.11 11.3 6.8 1.4 1 0 0 1 1 1 0 Otopetrin HMG_box PF00505.19 AMD21976.1 - 0.084 13.3 5.6 4 7.9 0.1 3.5 3 0 0 3 3 3 0 HMG (high mobility group) box eIF-3_zeta PF05091.12 AMD21976.1 - 0.24 10.3 26.1 0.44 9.5 26.1 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) YL1 PF05764.13 AMD21976.1 - 0.58 10.2 28.7 0.28 11.3 21.9 2.2 2 0 0 2 2 2 0 YL1 nuclear protein DUF4407 PF14362.6 AMD21976.1 - 0.59 9.4 32.6 1.3 8.3 32.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RPA43_OB PF17875.1 AMD21976.1 - 0.61 10.7 14.4 1.4 9.5 10.7 2.5 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I FAM60A PF15396.6 AMD21976.1 - 2.1 8.3 18.3 9.5 6.2 17.0 2.7 2 0 0 2 2 2 0 Protein Family FAM60A MAT1 PF06391.13 AMD21976.1 - 3.3 7.5 43.4 0.99 9.2 36.7 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 ABC_membrane PF00664.23 AMD21977.1 - 1.5e-67 228.1 32.3 2e-37 129.4 9.9 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 AMD21977.1 - 3.1e-48 163.8 0.0 7.1e-29 101.1 0.0 3.1 2 1 0 2 2 2 2 ABC transporter AAA_23 PF13476.6 AMD21977.1 - 5.4e-09 36.8 0.5 0.00015 22.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 AMD21977.1 - 1.2e-08 34.7 6.2 0.15 11.5 0.0 4.2 2 2 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AMD21977.1 - 1.4e-07 31.2 1.2 0.0023 17.6 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 AMD21977.1 - 1.1e-05 25.4 0.0 0.16 11.7 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 AMD21977.1 - 3.1e-05 24.0 1.4 0.018 15.0 0.3 2.4 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 AMD21977.1 - 6.9e-05 22.2 0.1 0.0097 15.2 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 AMD21977.1 - 0.00017 22.0 0.3 0.11 12.9 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 AMD21977.1 - 0.00073 19.6 0.1 0.72 9.9 0.0 2.8 2 0 0 2 2 2 2 Dynamin family AAA_18 PF13238.6 AMD21977.1 - 0.00092 19.8 2.8 1.2 9.7 0.0 3.6 4 0 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.23 AMD21977.1 - 0.0013 18.8 5.3 0.29 11.2 0.1 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_30 PF13604.6 AMD21977.1 - 0.017 14.9 1.6 1.5 8.5 0.1 2.8 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 AMD21977.1 - 0.023 14.5 8.0 0.47 10.2 0.2 4.1 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system FtsK_SpoIIIE PF01580.18 AMD21977.1 - 0.031 13.6 0.3 5.8 6.2 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_27 PF13514.6 AMD21977.1 - 0.054 13.1 0.2 2.3 7.8 0.1 2.3 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 AMD21977.1 - 0.078 12.0 1.4 1.6 7.7 0.2 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 AMD21977.1 - 0.18 11.4 0.9 1.4 8.5 0.3 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AMD21977.1 - 0.3 11.3 1.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 AMD21977.1 - 0.38 10.7 1.2 1.7 8.7 0.3 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 AMD21977.1 - 0.62 9.6 3.3 1.4 8.5 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 AMD21977.1 - 2.5 8.4 6.3 32 4.8 1.0 3.5 3 1 0 3 3 2 0 AAA domain Fungal_trans PF04082.18 AMD21978.1 - 2.5e-17 62.8 0.1 5.3e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Importin_rep_6 PF18829.1 AMD21979.1 - 7.8e-50 167.5 2.8 7.8e-50 167.5 2.8 4.2 5 0 0 5 5 5 1 Importin repeat 6 Importin_rep_4 PF18808.1 AMD21979.1 - 1.7e-31 108.3 1.4 1.7e-31 108.3 1.4 3.5 5 0 0 5 5 3 1 Importin repeat Importin_rep_5 PF18816.1 AMD21979.1 - 9.9e-24 83.4 1.3 9.9e-24 83.4 1.3 2.7 3 0 0 3 3 1 1 Importin repeat HEAT_EZ PF13513.6 AMD21979.1 - 1.4e-22 79.8 0.2 2.2e-11 44.0 0.0 7.7 5 1 2 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 AMD21979.1 - 7e-16 58.4 0.0 3.3e-06 27.4 0.0 7.1 4 2 3 7 7 7 4 HEAT repeats HEAT PF02985.22 AMD21979.1 - 1.8e-15 55.7 4.0 0.014 15.6 0.0 9.5 10 0 0 10 10 9 2 HEAT repeat Adaptin_N PF01602.20 AMD21979.1 - 4.1e-09 35.5 0.6 0.18 10.3 0.0 4.7 2 1 1 4 4 4 3 Adaptin N terminal region RIX1 PF08167.12 AMD21979.1 - 1.4e-08 34.7 1.9 0.0005 19.9 0.7 4.6 3 1 1 4 4 4 1 rRNA processing/ribosome biogenesis MMS19_C PF12460.8 AMD21979.1 - 5.9e-07 28.9 9.0 0.00032 19.9 4.9 3.2 2 0 0 2 2 2 2 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 AMD21979.1 - 2e-06 28.0 0.8 0.53 10.3 0.0 5.5 3 2 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AMD21979.1 - 2.4e-06 27.4 0.1 9.1 6.5 0.0 5.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat DUF3385 PF11865.8 AMD21979.1 - 3.2e-06 27.2 3.8 0.002 18.0 0.6 5.5 4 2 1 5 5 5 1 Domain of unknown function (DUF3385) Vac14_Fab1_bd PF12755.7 AMD21979.1 - 1.6e-05 25.4 0.1 0.58 10.8 0.0 5.7 3 2 3 6 6 6 1 Vacuolar 14 Fab1-binding region IFRD PF05004.13 AMD21979.1 - 6e-05 22.3 11.3 0.01 15.0 1.1 4.1 4 1 0 4 4 4 2 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 AMD21979.1 - 8.6e-05 22.2 0.2 0.15 11.6 0.8 5.0 4 2 2 6 6 6 1 CLASP N terminal ParcG PF10274.9 AMD21979.1 - 0.0016 18.6 3.2 0.13 12.4 0.0 3.5 4 0 0 4 4 3 1 Parkin co-regulated protein DNA_alkylation PF08713.11 AMD21979.1 - 0.0024 17.6 0.0 0.0087 15.8 0.0 2.0 1 1 0 1 1 1 1 DNA alkylation repair enzyme RTP1_C1 PF10363.9 AMD21979.1 - 0.038 14.2 1.8 23 5.2 0.1 4.6 5 0 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 SPO22 PF08631.10 AMD21979.1 - 0.29 10.6 3.1 6.2 6.2 0.1 3.4 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like PBP1_TM PF14812.6 AMD21979.1 - 4 7.9 8.8 0.19 12.1 0.5 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal G-patch PF01585.23 AMD21980.1 - 1.7e-09 37.4 0.5 3.4e-09 36.5 0.5 1.5 1 0 0 1 1 1 1 G-patch domain YL1 PF05764.13 AMD21980.1 - 0.00016 21.9 21.7 0.00021 21.5 21.7 1.2 1 0 0 1 1 1 1 YL1 nuclear protein G-patch_2 PF12656.7 AMD21980.1 - 0.013 15.5 0.2 0.013 15.5 0.2 3.0 2 1 0 2 2 1 0 G-patch domain CDC45 PF02724.14 AMD21980.1 - 0.14 10.5 19.5 0.17 10.1 19.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2112 PF09885.9 AMD21980.1 - 0.24 11.5 1.9 0.71 9.9 1.7 2.0 2 1 0 2 2 1 0 Uncharacterized protein conserved in archaea (DUF2112) DDHD PF02862.17 AMD21980.1 - 0.25 11.5 5.8 0.32 11.1 5.8 1.4 1 0 0 1 1 1 0 DDHD domain Vfa1 PF08432.10 AMD21980.1 - 0.33 11.3 23.7 0.6 10.4 23.7 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 AMD21980.1 - 0.74 9.6 21.2 1.2 8.9 21.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 AMD21980.1 - 0.91 9.5 6.9 1.1 9.2 6.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NARP1 PF12569.8 AMD21980.1 - 1.8 7.4 20.6 2.2 7.1 20.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Zip PF02535.22 AMD21980.1 - 2 7.6 8.8 2.4 7.3 8.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4407 PF14362.6 AMD21980.1 - 2.3 7.5 8.0 2.9 7.1 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM60A PF15396.6 AMD21980.1 - 2.7 8.0 18.6 4.3 7.3 18.6 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF4661 PF15576.6 AMD21980.1 - 3.8 7.3 12.1 7.5 6.4 12.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Connexin PF00029.19 AMD21980.1 - 3.9 7.2 12.2 6.5 6.4 12.2 1.5 1 0 0 1 1 1 0 Connexin Paramyxo_ncap PF00973.19 AMD21980.1 - 3.9 6.3 10.1 4.8 6.0 10.1 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Membralin PF09746.9 AMD21980.1 - 7.5 5.5 7.8 9.4 5.2 7.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein CPSF100_C PF13299.6 AMD21980.1 - 8.5 6.5 19.7 19 5.4 19.7 1.6 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ALMT PF11744.8 AMD21980.1 - 8.8 5.0 12.1 11 4.7 12.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Glyco_hydro_72 PF03198.14 AMD21981.1 - 1.2e-144 481.4 3.9 1.6e-144 480.9 3.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AMD21981.1 - 1.6e-25 89.5 4.2 5.2e-25 87.9 4.2 1.9 1 0 0 1 1 1 1 X8 domain AF-4 PF05110.13 AMD21981.1 - 3.6 5.5 8.1 5.1 5.0 8.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Glyco_hydro_72 PF03198.14 AMD21982.1 - 2.6e-134 447.4 4.1 3.7e-134 446.9 4.1 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AMD21982.1 - 4.9e-26 91.2 5.6 1.2e-25 90.0 5.6 1.7 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 AMD21982.1 - 0.00032 20.2 0.3 0.0078 15.7 0.3 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) E1-E2_ATPase PF00122.20 AMD21982.1 - 0.12 11.9 0.1 0.18 11.3 0.1 1.2 1 0 0 1 1 1 0 E1-E2 ATPase Glucan_synthase PF02364.15 AMD21983.1 - 0 1355.0 0.0 0 1355.0 0.0 1.8 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AMD21983.1 - 1.7e-40 138.4 0.7 7.8e-40 136.2 0.7 2.2 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 NOG1 PF06858.14 AMD21983.1 - 0.58 10.0 7.0 3 7.7 0.2 3.3 3 0 0 3 3 3 0 Nucleolar GTP-binding protein 1 (NOG1) Glyco_hydro_17 PF00332.18 AMD21984.1 - 1.5e-07 31.4 0.4 2.7e-07 30.5 0.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 MA3 PF02847.17 AMD21985.1 - 2e-21 76.1 0.5 6.3e-21 74.5 0.1 2.1 2 0 0 2 2 2 1 MA3 domain Glyco_hydro_57 PF03065.15 AMD21985.1 - 0.027 13.7 0.0 0.054 12.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 CTP_transf_like PF01467.26 AMD21986.1 - 1.4e-09 38.3 0.0 2.5e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like USP7_C2 PF14533.6 AMD21987.1 - 4.8e-57 193.0 3.0 4.8e-57 193.0 3.0 3.1 4 0 0 4 4 4 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 AMD21987.1 - 7.3e-46 156.7 1.5 7.3e-46 156.7 1.5 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 AMD21987.1 - 1.8e-32 112.6 1.9 1e-30 106.8 0.1 2.5 2 0 0 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 AMD21987.1 - 1.7e-23 83.8 0.2 4.3e-22 79.1 0.0 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 AMD21987.1 - 0.00053 20.1 0.0 0.0026 17.9 0.0 2.3 1 0 0 1 1 1 1 MATH domain UN_NPL4 PF11543.8 AMD21987.1 - 0.061 13.8 0.4 1.3 9.6 0.0 3.3 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 RNA12 PF10443.9 AMD21988.1 - 4.5e-168 559.6 0.2 6e-167 555.9 0.2 2.1 1 1 0 1 1 1 1 RNA12 protein RRM_1 PF00076.22 AMD21988.1 - 2.4e-06 27.3 0.0 7.6e-06 25.7 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 AMD21988.1 - 2.6e-06 27.5 0.9 4.4e-05 23.5 0.1 2.6 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 AMD21988.1 - 0.0019 18.2 0.0 0.015 15.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain SPT16 PF08644.11 AMD21988.1 - 0.021 15.0 0.1 0.23 11.6 0.0 2.6 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) ADH_zinc_N PF00107.26 AMD21989.1 - 1e-20 74.0 0.4 1.6e-20 73.4 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 AMD21989.1 - 4.7e-19 68.3 0.0 7.7e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 AMD21989.1 - 2.8e-06 28.4 0.0 5.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 AMD21989.1 - 0.038 13.7 0.4 0.12 12.1 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2855) LAB_N PF07578.11 AMD21989.1 - 0.063 13.4 0.4 0.13 12.3 0.4 1.5 1 0 0 1 1 1 0 Lipid A Biosynthesis N-terminal domain Transp_cyt_pur PF02133.15 AMD21990.1 - 7e-71 239.3 34.6 1.1e-70 238.6 34.6 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin FH2 PF02181.23 AMD21991.1 - 8.6e-68 229.1 8.2 8.6e-68 229.1 8.2 2.5 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 AMD21991.1 - 1.3e-08 34.6 1.9 1.3e-08 34.6 1.9 4.0 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain CheB_methylest PF01339.17 AMD21991.1 - 0.034 13.9 0.0 0.11 12.2 0.0 1.9 1 0 0 1 1 1 0 CheB methylesterase W2 PF02020.18 AMD21991.1 - 0.25 11.5 2.4 6 7.1 0.4 3.7 3 0 0 3 3 3 0 eIF4-gamma/eIF5/eIF2-epsilon Med9 PF07544.13 AMD21991.1 - 4.6 7.4 7.5 4.9 7.3 3.9 2.8 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Pyrid_oxidase_2 PF13883.6 AMD21992.1 - 8.7e-15 55.1 0.0 1.5e-14 54.4 0.0 1.3 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Guanylate_cyc_2 PF09778.9 AMD21992.1 - 0.003 16.9 0.0 0.0035 16.7 0.0 1.1 1 0 0 1 1 1 1 Guanylylate cyclase Aldo_ket_red PF00248.21 AMD21993.1 - 2.9e-47 161.3 0.0 2e-45 155.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Asp PF00026.23 AMD21994.1 - 4.2e-68 230.1 0.0 4.9e-68 229.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD21994.1 - 7e-08 32.9 0.2 3.4e-07 30.7 0.2 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Lys PF00062.20 AMD21995.1 - 0.0033 17.6 0.1 0.0051 17.1 0.1 1.3 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family Aminotran_4 PF01063.19 AMD21996.1 - 3e-34 118.9 0.0 4e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV 5-FTHF_cyc-lig PF01812.20 AMD21997.1 - 7.7e-41 140.0 0.0 8.9e-41 139.8 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family SET PF00856.28 AMD21999.1 - 3e-13 50.5 0.0 1e-12 48.8 0.0 1.9 1 1 0 1 1 1 1 SET domain GAGA PF09237.11 AMD21999.1 - 0.095 12.5 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 GAGA factor HSF_DNA-bind PF00447.17 AMD22000.1 - 3.7e-31 107.6 4.4 8.1e-31 106.5 4.4 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 AMD22000.1 - 3.8e-28 97.9 0.2 9.6e-28 96.6 0.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HALZ PF02183.18 AMD22000.1 - 0.015 15.5 0.3 0.028 14.6 0.3 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper HAP1_N PF04849.13 AMD22000.1 - 0.027 13.7 0.1 0.041 13.1 0.1 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region bZIP_1 PF00170.21 AMD22000.1 - 0.046 13.8 0.3 0.13 12.4 0.3 1.8 1 0 0 1 1 1 0 bZIP transcription factor Ets PF00178.22 AMD22000.1 - 0.053 14.0 0.1 0.12 12.8 0.1 1.6 1 0 0 1 1 1 0 Ets-domain 3HCDH_RFF PF18321.1 AMD22000.1 - 0.092 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain TSC22 PF01166.18 AMD22000.1 - 0.095 13.0 0.3 0.25 11.7 0.3 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family DivIC PF04977.15 AMD22000.1 - 0.15 11.8 0.2 0.34 10.7 0.2 1.5 1 0 0 1 1 1 0 Septum formation initiator Pkinase PF00069.25 AMD22001.1 - 1.3e-67 228.0 0.0 1.7e-67 227.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22001.1 - 4.4e-31 108.1 0.0 6.5e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 AMD22001.1 - 3.3e-10 40.5 3.0 3.3e-10 40.5 3.0 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 AMD22001.1 - 6.2e-10 39.3 0.0 2e-06 28.0 0.0 2.7 2 0 0 2 2 2 2 C2 domain Kinase-like PF14531.6 AMD22001.1 - 8.1e-09 35.2 0.1 6.2e-08 32.3 0.0 2.3 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 AMD22001.1 - 0.0011 17.9 0.1 0.0035 16.3 0.1 1.8 1 1 0 1 1 1 1 Haspin like kinase domain DUF4832 PF16116.5 AMD22001.1 - 0.036 13.9 0.0 0.4 10.5 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4832) FTA2 PF13095.6 AMD22001.1 - 0.042 13.5 0.2 0.46 10.1 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 AMD22001.1 - 0.098 12.2 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Glyco_hydro_47 PF01532.20 AMD22002.1 - 7.7e-116 387.7 0.5 9.3e-116 387.4 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ribosomal_S4e PF00900.20 AMD22003.1 - 1.4e-39 133.8 1.1 5.1e-39 132.0 1.1 1.9 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 AMD22003.1 - 1.5e-26 91.8 0.0 2.9e-26 90.8 0.0 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 AMD22003.1 - 8e-20 70.7 6.9 2.4e-19 69.2 6.9 1.9 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 AMD22003.1 - 6.9e-08 32.1 0.7 1.3e-07 31.2 0.0 1.9 2 0 0 2 2 2 1 S4 domain KOW PF00467.29 AMD22003.1 - 1.1e-05 25.1 1.5 1.1e-05 25.1 1.5 2.9 3 0 0 3 3 3 1 KOW motif Metallophos PF00149.28 AMD22004.1 - 5.7e-13 49.8 1.2 5.7e-13 49.8 1.2 1.8 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 AMD22004.1 - 0.082 13.1 0.0 0.22 11.7 0.0 1.7 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain CoA_binding PF02629.19 AMD22005.1 - 1.9e-24 86.2 3.2 2.3e-24 85.9 0.9 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 AMD22005.1 - 2.2e-24 86.0 0.6 4e-24 85.2 0.6 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 AMD22005.1 - 1.5e-08 34.5 0.1 2.8e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AMD22005.1 - 6.3e-06 26.7 0.1 1.8e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 CoA binding domain Actin PF00022.19 AMD22006.1 - 7.5e-23 80.8 0.0 4.3e-15 55.2 0.0 3.4 3 1 0 3 3 3 3 Actin Actin_micro PF17003.5 AMD22006.1 - 4.4e-08 32.7 13.0 9.1e-05 21.8 0.4 3.0 2 1 1 3 3 3 2 Putative actin-like family MreB_Mbl PF06723.13 AMD22006.1 - 7.3e-06 25.0 0.0 0.00089 18.2 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 AMD22006.1 - 0.0088 16.5 0.7 0.037 14.5 0.7 2.3 1 1 0 1 1 1 1 Cell division protein FtsA DUF507 PF04368.13 AMD22006.1 - 0.28 11.1 6.2 7.3 6.5 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF507) HSA PF07529.13 AMD22006.1 - 7.6 6.9 6.8 13 6.2 1.7 2.4 2 0 0 2 2 2 0 HSA HSF_DNA-bind PF00447.17 AMD22007.1 - 2.2e-30 105.1 0.3 6.3e-30 103.7 0.3 1.8 1 0 0 1 1 1 1 HSF-type DNA-binding Iso_dh PF00180.20 AMD22008.1 - 1e-100 337.3 0.1 1.3e-100 337.0 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HHH_2 PF12826.7 AMD22008.1 - 0.084 13.0 0.0 2.4 8.3 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif ThiF PF00899.21 AMD22009.1 - 1.3e-66 224.4 0.0 1.9e-66 223.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 AMD22009.1 - 2.8e-06 27.4 5.3 0.0029 17.6 0.0 2.7 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 AMD22009.1 - 0.047 14.3 0.4 0.047 14.3 0.4 3.3 4 0 0 4 4 4 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.20 AMD22009.1 - 0.075 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 AMD22009.1 - 0.11 13.0 0.0 0.36 11.3 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding RhoGAP PF00620.27 AMD22010.1 - 1.5e-31 109.3 0.0 4.3e-18 65.6 0.0 2.6 2 0 0 2 2 2 2 RhoGAP domain Syntaxin_2 PF14523.6 AMD22010.1 - 0.059 13.7 0.5 1.1 9.7 0.5 2.7 2 0 0 2 2 2 0 Syntaxin-like protein BAR PF03114.18 AMD22011.1 - 3.9e-55 187.1 9.5 4.9e-55 186.8 9.5 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 AMD22011.1 - 1.3e-12 47.3 0.1 2.7e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AMD22011.1 - 1.2e-11 44.0 1.3 1.7e-11 43.5 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 AMD22011.1 - 3.1e-05 23.6 0.0 6.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain pPIWI_RE_Z PF18155.1 AMD22011.1 - 0.014 15.2 1.1 0.028 14.3 1.1 1.4 1 0 0 1 1 1 0 pPIWI RE three-gene island domain Z Radial_spoke_3 PF06098.11 AMD22011.1 - 0.024 13.9 6.4 0.061 12.6 6.4 1.7 1 0 0 1 1 1 0 Radial spoke protein 3 DUF4375 PF14300.6 AMD22011.1 - 0.11 12.8 4.3 0.37 11.1 4.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) DUF3903 PF13043.6 AMD22011.1 - 0.12 12.1 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3903) ERCC4 PF02732.15 AMD22012.1 - 4e-20 72.6 0.1 3.4e-19 69.6 0.1 2.5 2 0 0 2 2 2 1 ERCC4 domain HHH_8 PF14716.6 AMD22012.1 - 0.0033 17.8 0.0 0.0071 16.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain GTP_EFTU PF00009.27 AMD22013.1 - 1.2e-67 227.2 0.2 1.7e-67 226.8 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AMD22013.1 - 3.2e-33 114.1 0.0 8.3e-33 112.7 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 AMD22013.1 - 4.2e-22 78.0 0.0 1.3e-21 76.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AMD22013.1 - 2.4e-14 53.4 0.0 9.1e-14 51.6 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 AMD22013.1 - 6e-13 48.7 0.0 2.3e-12 46.8 0.0 2.0 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 AMD22013.1 - 9.6e-05 22.4 0.2 0.00019 21.5 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PX PF00787.24 AMD22014.1 - 6.9e-10 38.9 2.3 7.8e-10 38.7 0.1 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 AMD22014.1 - 1.8e-05 24.4 9.2 2.9e-05 23.7 9.2 1.2 1 0 0 1 1 1 1 Vps5 C terminal like MBD_C PF14048.6 AMD22014.1 - 0.048 14.4 1.0 1.7 9.4 0.0 2.9 2 1 0 2 2 2 0 C-terminal domain of methyl-CpG binding protein 2 and 3 IZUMO PF15005.6 AMD22014.1 - 0.96 10.0 7.1 0.4 11.2 0.5 3.0 2 1 1 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated MFS_1 PF07690.16 AMD22015.1 - 2.3e-23 82.7 33.7 2.3e-23 82.7 33.7 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AMD22015.1 - 2.4e-23 82.7 27.5 5.6e-23 81.5 27.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2975 PF11188.8 AMD22015.1 - 1.1 9.1 8.1 6.9 6.6 0.8 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) CbtB PF09489.10 AMD22015.1 - 1.3 9.2 0.0 1.3 9.2 0.0 3.7 4 0 0 4 4 4 0 Probable cobalt transporter subunit (CbtB) Ribosomal_L4 PF00573.22 AMD22016.1 - 2.1e-41 141.7 1.4 3.7e-41 140.9 1.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 AMD22016.1 - 7e-31 106.1 4.9 2.3e-30 104.5 1.3 2.7 2 1 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Methyltransf_25 PF13649.6 AMD22017.1 - 4.1e-13 49.8 0.0 1.4e-11 44.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 AMD22017.1 - 6.8e-11 42.1 0.0 1.1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 AMD22017.1 - 2.8e-10 40.2 0.0 8.3e-10 38.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AMD22017.1 - 9.4e-09 35.8 0.0 6.2e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AMD22017.1 - 7.8e-08 32.3 0.0 1.3e-07 31.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AMD22017.1 - 2.8e-07 30.1 0.0 3.9e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 AMD22017.1 - 6.4e-06 25.3 0.0 8.5e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 AMD22017.1 - 2.3e-05 24.0 0.0 4.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 AMD22017.1 - 6.4e-05 22.9 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AMD22017.1 - 0.00045 20.9 0.0 0.0014 19.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.9 AMD22017.1 - 0.00097 18.9 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PCMT PF01135.19 AMD22017.1 - 0.0014 18.5 0.1 0.002 17.9 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 AMD22017.1 - 0.0015 18.0 0.1 0.0036 16.7 0.1 1.6 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 AMD22017.1 - 0.0034 17.5 0.0 0.007 16.5 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 AMD22017.1 - 0.02 14.9 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 AMD22017.1 - 0.05 13.4 0.0 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_24 PF13578.6 AMD22017.1 - 0.056 14.5 0.0 0.11 13.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 AMD22017.1 - 0.063 13.1 0.1 0.21 11.4 0.0 1.9 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase Cons_hypoth95 PF03602.15 AMD22017.1 - 0.097 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Sld5 PF05916.11 AMD22018.1 - 2.3e-09 37.7 0.3 4.1e-09 36.9 0.3 1.4 1 0 0 1 1 1 1 GINS complex protein PIF1 PF05970.14 AMD22018.1 - 0.0081 15.4 0.0 0.019 14.2 0.0 1.5 1 1 1 2 2 2 1 PIF1-like helicase AKNA PF12443.8 AMD22018.1 - 0.026 15.2 0.6 0.068 13.8 0.6 1.6 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF2748 PF10871.8 AMD22018.1 - 0.07 11.7 0.1 0.095 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) Wap1 PF16997.5 AMD22019.1 - 4.1e-89 299.4 6.4 5e-89 299.1 6.4 1.1 1 0 0 1 1 1 1 Wap1 domain PNP_phzG_C PF10590.9 AMD22020.1 - 1.9e-17 63.0 1.9 4.7e-17 61.8 1.9 1.7 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 AMD22020.1 - 4.2e-15 55.7 0.0 1e-14 54.5 0.0 1.6 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 AMD22020.1 - 0.00013 22.5 0.1 0.00026 21.6 0.1 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AMD22020.1 - 0.027 14.0 0.2 0.29 10.7 0.0 2.1 1 1 1 2 2 2 0 Pyridoxamine 5'-phosphate oxidase like DUF1776 PF08643.10 AMD22020.1 - 0.049 13.0 0.1 0.072 12.4 0.1 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF1451 PF07295.11 AMD22020.1 - 0.2 11.7 0.1 0.82 9.7 0.0 1.8 2 0 0 2 2 2 0 Zinc-ribbon containing domain DASH_Dad1 PF08649.10 AMD22021.1 - 5.1e-25 87.4 2.4 8e-25 86.8 1.5 1.7 2 0 0 2 2 2 1 DASH complex subunit Dad1 IPK PF03770.16 AMD22022.1 - 3.3e-49 167.4 0.2 3.3e-49 167.4 0.2 1.8 2 0 0 2 2 2 1 Inositol polyphosphate kinase ATP-synt PF00231.19 AMD22023.1 - 2.7e-76 257.0 6.3 3e-76 256.8 6.3 1.0 1 0 0 1 1 1 1 ATP synthase Fig1 PF12351.8 AMD22024.1 - 1.2e-40 139.5 4.7 1.2e-40 139.5 4.7 1.6 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 AMD22024.1 - 0.1 12.2 13.7 0.24 11.0 13.7 1.6 1 1 0 1 1 1 0 SUR7/PalI family zf-LITAF-like PF10601.9 AMD22024.1 - 2.1 8.6 6.6 5.3 7.4 0.0 3.1 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain AMP-binding PF00501.28 AMD22025.1 - 2.7e-58 197.6 0.0 3.2e-58 197.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AMD22025.1 - 4.2e-06 27.6 0.0 1e-05 26.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acyltransferase PF01553.21 AMD22026.1 - 1.5e-27 95.9 0.0 2.3e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 AMD22026.1 - 2e-15 56.6 0.0 6.5e-15 55.0 0.0 1.9 1 0 0 1 1 1 1 Acyltransferase C-terminus MFS_1 PF07690.16 AMD22027.1 - 5.8e-38 130.7 34.9 5.8e-38 130.7 34.9 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 AMD22027.1 - 1.3e-06 28.0 4.5 1.3e-06 28.0 4.5 1.7 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Dynamin_M PF01031.20 AMD22028.1 - 0.013 14.7 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Dynamin central region Importin_rep_6 PF18829.1 AMD22028.1 - 0.037 14.2 0.0 0.056 13.6 0.0 1.5 1 1 0 1 1 1 0 Importin repeat 6 YCII PF03795.14 AMD22030.1 - 3.6e-08 33.7 0.0 4.3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Profilin PF00235.19 AMD22031.1 - 2.1e-44 150.8 0.2 2.4e-44 150.7 0.2 1.0 1 0 0 1 1 1 1 Profilin NTNH_C PF08470.10 AMD22031.1 - 0.17 11.8 0.0 0.22 11.4 0.0 1.1 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal Leo1 PF04004.13 AMD22032.1 - 3.5e-45 153.8 0.4 1e-44 152.3 0.4 1.8 1 0 0 1 1 1 1 Leo1-like protein Glyco_hydro_18 PF00704.28 AMD22033.1 - 1.8e-71 241.4 1.6 2.2e-71 241.1 1.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.11 AMD22034.1 - 1.2e-65 221.4 0.0 1.5e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) UCH PF00443.29 AMD22035.1 - 1.8e-54 185.0 0.0 6.1e-54 183.2 0.0 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 AMD22035.1 - 2.4e-39 133.1 15.1 4.5e-15 55.3 0.2 6.0 6 0 0 6 6 6 4 A repeated domain in UCH-protein UCH_1 PF13423.6 AMD22035.1 - 1 8.9 17.9 0.3 10.6 4.3 3.4 2 2 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase EF-hand_1 PF00036.32 AMD22036.1 - 3.5e-28 95.0 7.3 8.6e-08 31.2 0.3 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AMD22036.1 - 1.6e-27 95.7 5.5 1.4e-17 63.9 0.4 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AMD22036.1 - 7.5e-25 84.7 5.4 7.9e-07 28.5 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 AMD22036.1 - 4.2e-17 60.8 9.9 8.4e-06 25.1 0.3 5.1 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 AMD22036.1 - 1.3e-16 60.2 8.9 6.5e-09 35.5 0.2 4.0 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 AMD22036.1 - 1.4e-05 25.4 2.0 0.17 12.2 0.1 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 AMD22036.1 - 3.3e-05 23.8 5.7 0.56 10.2 0.1 3.6 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 AMD22036.1 - 0.0013 19.0 0.5 0.31 11.4 0.1 3.0 1 1 1 2 2 2 1 EF-hand domain DUF5552 PF17706.1 AMD22036.1 - 0.025 14.3 0.0 0.033 13.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5552) S10_plectin PF03501.15 AMD22036.1 - 0.089 12.9 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 Plectin/S10 domain Pan3_PK PF18101.1 AMD22036.1 - 0.13 12.2 0.5 0.27 11.2 0.1 1.7 2 0 0 2 2 2 0 Pan3 Pseudokinase domain COQ7 PF03232.13 AMD22037.1 - 1.9e-73 245.9 0.8 2.8e-73 245.3 0.1 1.5 2 0 0 2 2 2 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 AMD22037.1 - 0.058 13.8 0.1 0.18 12.2 0.0 1.9 2 0 0 2 2 2 0 Rubrerythrin YTH PF04146.15 AMD22038.1 - 4e-31 108.2 1.6 4.6e-31 108.0 0.2 1.8 2 1 0 2 2 2 1 YT521-B-like domain Sel1 PF08238.12 AMD22039.1 - 8.7e-20 70.7 19.8 0.0013 19.4 0.4 7.9 9 0 0 9 9 9 5 Sel1 repeat TPR_12 PF13424.6 AMD22039.1 - 0.00021 21.5 3.9 0.16 12.2 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 AMD22039.1 - 0.0038 17.2 3.2 3 8.1 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 AMD22039.1 - 0.0058 16.7 14.7 3.5 8.1 0.2 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 AMD22039.1 - 0.49 10.6 15.0 0.27 11.5 0.3 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 AMD22039.1 - 4.3 7.3 16.3 1.6 8.7 0.4 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Dynactin_p62 PF05502.13 AMD22040.1 - 2.7e-10 39.6 25.4 6.4e-05 21.9 0.1 2.1 1 1 1 2 2 2 2 Dynactin p62 family CENP-X PF09415.10 AMD22041.1 - 2.5e-21 75.7 0.2 2.9e-21 75.6 0.2 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X ENTH PF01417.20 AMD22042.1 - 1.1e-41 141.8 0.0 2.2e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 ENTH domain DNA_ligase_A_M PF01068.21 AMD22043.1 - 2.7e-63 213.3 0.0 4.4e-63 212.6 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 AMD22043.1 - 1.8e-42 145.6 0.0 2.9e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 AMD22043.1 - 1.5e-23 83.3 0.0 4.7e-23 81.6 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 AMD22043.1 - 5.2e-06 26.9 0.0 1.3e-05 25.6 0.0 1.7 2 0 0 2 2 2 1 RNA ligase DUF1713 PF08213.11 AMD22044.1 - 1.8e-12 46.9 18.2 2.6e-12 46.4 18.2 1.2 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) zf-Mss51 PF13824.6 AMD22045.1 - 5.8e-18 64.7 0.9 5.8e-18 64.7 0.9 1.8 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 NOT2_3_5 PF04153.18 AMD22046.1 - 4.7e-31 107.6 0.2 6.7e-31 107.1 0.2 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family AAA_18 PF13238.6 AMD22047.1 - 4.3e-32 111.4 0.7 1e-31 110.1 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AMD22047.1 - 2.2e-07 31.4 0.1 1.6e-06 28.6 0.1 2.2 1 1 1 2 2 1 1 AAA domain AAA_28 PF13521.6 AMD22047.1 - 3.4e-05 24.1 0.0 0.00011 22.5 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AMD22047.1 - 0.00012 22.4 0.0 0.00041 20.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 AMD22047.1 - 0.00017 22.1 0.0 0.00034 21.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) dNK PF01712.19 AMD22047.1 - 0.00022 21.1 0.2 0.051 13.4 0.0 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase RNA_helicase PF00910.22 AMD22047.1 - 0.00029 21.2 0.1 0.00061 20.2 0.1 1.5 1 0 0 1 1 1 1 RNA helicase Thymidylate_kin PF02223.17 AMD22047.1 - 0.00032 20.4 0.1 0.22 11.2 0.0 2.4 2 1 0 2 2 2 2 Thymidylate kinase KTI12 PF08433.10 AMD22047.1 - 0.0013 18.2 0.0 0.018 14.5 0.0 2.1 2 0 0 2 2 2 1 Chromatin associated protein KTI12 GvpD PF07088.11 AMD22047.1 - 0.0014 17.4 0.0 0.0014 17.3 0.0 1.3 1 1 0 1 1 1 1 GvpD gas vesicle protein AAA_14 PF13173.6 AMD22047.1 - 0.0017 18.4 0.1 0.0084 16.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AMD22047.1 - 0.0033 16.7 0.0 0.0058 15.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 AMD22047.1 - 0.0033 17.6 0.1 0.86 9.8 0.0 2.8 1 1 2 3 3 3 1 AAA domain NTPase_1 PF03266.15 AMD22047.1 - 0.0039 17.1 0.0 0.008 16.1 0.0 1.5 1 0 0 1 1 1 1 NTPase Rad17 PF03215.15 AMD22047.1 - 0.005 16.8 0.0 0.0083 16.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain ADK PF00406.22 AMD22047.1 - 0.0052 16.9 0.0 0.82 9.8 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase PduV-EutP PF10662.9 AMD22047.1 - 0.0053 16.5 0.1 0.049 13.4 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 AMD22047.1 - 0.0067 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 AMD22047.1 - 0.0074 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 AMD22047.1 - 0.0075 16.7 0.0 0.0088 16.4 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 AMD22047.1 - 0.015 15.8 0.0 0.07 13.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter Cytidylate_kin2 PF13189.6 AMD22047.1 - 0.017 15.2 0.1 0.035 14.3 0.1 1.8 1 1 0 1 1 1 0 Cytidylate kinase-like family AAA_15 PF13175.6 AMD22047.1 - 0.028 14.1 0.0 0.036 13.8 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 AMD22047.1 - 0.049 13.0 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SRPRB PF09439.10 AMD22047.1 - 0.061 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_19 PF13245.6 AMD22047.1 - 0.13 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 AMD22047.1 - 0.14 11.2 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 AMD22047.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region RuvB_N PF05496.12 AMD22047.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 AMD22047.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-RanBP PF00641.18 AMD22048.1 - 1e-18 66.3 10.7 6.8e-10 38.1 1.7 2.6 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 AMD22048.1 - 3.5e-07 29.9 0.0 0.00076 19.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 AMD22048.1 - 0.13 12.2 22.0 0.21 11.5 22.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit O-antigen_lig PF13425.6 AMD22048.1 - 0.63 8.8 4.4 0.88 8.3 4.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DZR PF12773.7 AMD22048.1 - 1.2 9.2 10.2 3.9 7.6 1.3 2.5 2 0 0 2 2 2 0 Double zinc ribbon Dicty_REP PF05086.12 AMD22048.1 - 1.3 7.0 6.5 1.9 6.4 6.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Rubredoxin PF00301.20 AMD22048.1 - 3.9 7.6 6.2 1.2 9.2 0.7 2.6 2 0 0 2 2 2 0 Rubredoxin ADH_N PF08240.12 AMD22049.1 - 1.6e-23 82.7 1.7 1.6e-23 82.7 1.7 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AMD22049.1 - 1e-19 70.8 1.2 1.3e-19 70.5 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 AMD22049.1 - 0.025 13.9 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 AMD22049.1 - 0.036 14.3 0.0 0.09 13.0 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain ADH_zinc_N_2 PF13602.6 AMD22049.1 - 0.058 14.4 0.0 0.13 13.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Gp_dh_N PF00044.24 AMD22049.1 - 0.14 12.5 0.2 0.58 10.5 0.0 2.1 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain SAVED PF18145.1 AMD22049.1 - 0.22 11.3 0.0 0.34 10.7 0.0 1.2 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain COQ9 PF08511.11 AMD22050.1 - 4.2e-22 77.7 0.2 8.5e-22 76.7 0.2 1.5 1 0 0 1 1 1 1 COQ9 Prefoldin_2 PF01920.20 AMD22051.1 - 1e-22 80.1 11.4 1.1e-22 80.0 11.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit Rh5 PF18515.1 AMD22051.1 - 0.0009 18.6 2.6 0.0011 18.3 2.6 1.2 1 0 0 1 1 1 1 Rh5 coiled-coil domain DUF1192 PF06698.11 AMD22051.1 - 0.031 14.3 0.4 0.031 14.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) FliJ PF02050.16 AMD22051.1 - 0.066 13.4 6.9 2.9 8.1 0.1 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein DUF4200 PF13863.6 AMD22051.1 - 0.067 13.6 12.7 0.42 11.0 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) MIP-T3_C PF17749.1 AMD22051.1 - 0.32 10.9 8.4 0.12 12.3 1.4 2.0 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region DUF4085 PF13315.6 AMD22051.1 - 0.36 10.4 6.7 1.2 8.7 1.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4085) Uso1_p115_C PF04871.13 AMD22051.1 - 0.59 10.5 9.4 1.7 9.0 2.6 2.1 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Bcr-Abl_Oligo PF09036.10 AMD22051.1 - 0.9 9.6 5.2 0.61 10.1 0.9 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Spc24 PF08286.11 AMD22051.1 - 2.9 8.2 11.5 2.3 8.5 2.1 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 POC1 PF10450.9 AMD22052.1 - 1.2e-41 142.6 0.0 1.3e-41 142.4 0.0 1.0 1 0 0 1 1 1 1 POC1 chaperone Nop PF01798.18 AMD22053.1 - 2.5e-84 282.4 0.1 2.5e-84 282.4 0.1 2.3 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 AMD22053.1 - 8e-19 67.8 0.3 8e-19 67.8 0.3 3.4 2 1 1 3 3 3 1 NOP5NT (NUC127) domain Cdc6_C PF09079.11 AMD22054.1 - 5e-14 52.0 0.2 1.1e-13 51.0 0.2 1.6 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA PF00004.29 AMD22054.1 - 1.2e-09 38.7 0.3 1.4e-08 35.2 0.0 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD22054.1 - 1.5e-09 38.3 0.0 4.3e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AMD22054.1 - 1.6e-07 31.8 0.0 4.2e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 AMD22054.1 - 4.1e-05 23.2 0.0 0.22 11.0 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region API5 PF05918.11 AMD22054.1 - 0.00088 18.2 0.1 0.0015 17.5 0.1 1.4 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) SieB PF14163.6 AMD22054.1 - 0.013 15.0 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Super-infection exclusion protein B AAA_18 PF13238.6 AMD22054.1 - 0.023 15.3 0.0 0.092 13.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AMD22054.1 - 0.06 13.1 0.2 0.14 11.9 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 AMD22054.1 - 0.087 13.2 1.2 0.47 10.8 0.0 2.7 3 2 0 3 3 3 0 AAA domain AAA_30 PF13604.6 AMD22054.1 - 0.098 12.4 0.0 0.29 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Beach PF02138.18 AMD22055.1 - 2.9e-116 387.7 0.0 7.5e-116 386.3 0.0 1.8 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 AMD22055.1 - 3.6e-11 43.0 0.0 9.1e-11 41.7 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 AMD22055.1 - 0.045 13.9 0.1 0.15 12.2 0.1 1.9 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily SOP4 PF17081.5 AMD22056.1 - 1.9e-85 285.6 0.2 2.3e-85 285.4 0.2 1.0 1 0 0 1 1 1 1 Suppressor of PMA 1-7 protein DUF2012 PF09430.10 AMD22056.1 - 0.016 15.3 0.1 0.025 14.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Ribosomal_S11 PF00411.19 AMD22057.1 - 7e-46 155.2 2.1 8.7e-46 154.9 2.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 BKACE PF05853.12 AMD22057.1 - 0.066 12.5 0.3 0.081 12.2 0.3 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme Ribosomal_S8 PF00410.19 AMD22058.1 - 1.1e-23 83.6 0.1 1.7e-23 83.0 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L39 PF00832.20 AMD22059.1 - 5.5e-21 73.9 12.0 6.6e-21 73.7 12.0 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein PI_PP_I PF18363.1 AMD22059.1 - 0.005 17.0 0.2 0.005 17.0 0.2 1.2 1 0 0 1 1 1 1 Phosphoinositide phosphatase insertion domain YchF-GTPase_C PF06071.13 AMD22060.1 - 1.6e-36 124.4 0.8 2.9e-36 123.5 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 AMD22060.1 - 9.4e-17 61.1 0.0 2e-16 60.1 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 AMD22060.1 - 0.00027 20.9 0.0 0.0006 19.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AMD22060.1 - 0.0076 15.8 0.0 0.018 14.6 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B BetaGal_dom3 PF13363.6 AMD22060.1 - 0.1 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase, domain 3 Cupin_2 PF07883.11 AMD22060.1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Cupin domain SCO1-SenC PF02630.14 AMD22061.1 - 1.8e-47 160.6 0.0 3e-47 159.9 0.0 1.4 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 AMD22061.1 - 0.029 14.3 0.0 0.053 13.4 0.0 1.5 1 1 0 1 1 1 0 AhpC/TSA family DUF4169 PF13770.6 AMD22061.1 - 0.035 14.4 0.5 0.066 13.5 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) Chitin_synth_1 PF01644.17 AMD22062.1 - 4.8e-65 218.5 0.3 9.1e-65 217.6 0.3 1.5 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 AMD22062.1 - 3.2e-21 75.6 6.0 1.1e-16 60.6 0.0 3.0 2 1 0 3 3 3 2 Chitin synthase Chitin_synth_1N PF08407.11 AMD22062.1 - 7.8e-21 73.8 0.1 2.4e-20 72.2 0.0 1.9 2 0 0 2 2 2 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.6 AMD22062.1 - 0.00015 21.8 6.0 0.00015 21.8 6.0 2.6 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 AMD22062.1 - 0.12 12.2 0.0 0.33 10.8 0.0 1.7 1 1 0 1 1 1 0 Glycosyltransferase like family 2 DUF2576 PF10845.8 AMD22062.1 - 0.13 11.9 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Chitin_synth_2 PF03142.15 AMD22063.1 - 3.2e-275 913.7 0.1 4.9e-275 913.1 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AMD22063.1 - 8.5e-12 45.4 4.9 4.4e-11 43.1 4.9 2.2 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 AMD22063.1 - 1e-10 41.9 0.0 1e-08 35.4 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 AMD22063.1 - 0.00021 21.1 0.0 0.013 15.3 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 AMD22063.1 - 0.00044 19.8 0.0 0.00092 18.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 RNR_inhib PF08591.10 AMD22064.1 - 1.2e-07 33.0 0.1 2.4e-07 32.0 0.1 1.5 1 1 0 1 1 1 1 Ribonucleotide reductase inhibitor Aminotran_3 PF00202.21 AMD22065.1 - 1e-120 403.1 0.0 1.2e-120 402.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 AMD22065.1 - 0.00018 20.9 0.0 0.00036 19.9 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AMD22065.1 - 0.1 11.9 0.0 0.36 10.1 0.0 1.8 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family OAM_dimer PF16554.5 AMD22065.1 - 0.12 12.8 0.1 1.1 9.8 0.0 2.3 2 0 0 2 2 2 0 Dimerisation domain of d-ornithine 4,5-aminomutase cNMP_binding PF00027.29 AMD22066.1 - 2.8e-27 94.6 0.1 2.5e-11 43.5 0.0 5.5 4 1 0 4 4 4 3 Cyclic nucleotide-binding domain Patatin PF01734.22 AMD22066.1 - 3.5e-18 66.5 3.4 5.6e-12 46.3 0.8 3.0 3 0 0 3 3 3 2 Patatin-like phospholipase DPM3 PF08285.11 AMD22066.1 - 0.026 14.7 1.0 0.062 13.5 1.0 1.6 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LSM PF01423.22 AMD22067.1 - 9.4e-20 70.1 0.1 1.1e-19 69.9 0.1 1.0 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 AMD22067.1 - 0.0063 16.6 0.0 0.012 15.7 0.0 1.5 2 0 0 2 2 2 1 RimP C-terminal SH3 domain MRP-L47 PF06984.13 AMD22068.1 - 2.6e-24 85.2 2.9 3.9e-24 84.6 0.9 2.2 2 0 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) OGG_N PF07934.12 AMD22069.1 - 2.7e-24 85.6 0.4 5.6e-24 84.5 0.4 1.6 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 AMD22069.1 - 2.6e-16 60.0 0.0 5e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein T6SS_TssG PF06996.11 AMD22069.1 - 0.076 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion, TssG HHH PF00633.23 AMD22069.1 - 0.09 12.7 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif PIF1 PF05970.14 AMD22070.1 - 1.1e-66 225.5 2.1 7.2e-54 183.3 0.6 2.4 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 AMD22070.1 - 2.1e-20 73.3 0.0 3.7e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD22070.1 - 5.3e-09 36.6 0.0 1.6e-08 35.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.14 AMD22070.1 - 0.00029 18.9 0.5 0.00082 17.4 0.0 1.8 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.6 AMD22070.1 - 0.00043 20.6 0.0 0.0015 18.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 AMD22070.1 - 0.0019 18.0 0.0 0.036 13.9 0.0 2.6 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 AMD22070.1 - 0.0024 17.6 0.2 0.43 10.3 0.2 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA PF00004.29 AMD22070.1 - 0.0073 16.7 0.1 0.024 15.0 0.1 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 AMD22070.1 - 0.011 14.8 0.1 0.023 13.8 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 AMD22070.1 - 0.011 15.2 0.6 0.045 13.3 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region SH3_13 PF18335.1 AMD22070.1 - 0.012 15.5 0.0 0.043 13.7 0.0 1.9 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain DEAD PF00270.29 AMD22070.1 - 0.019 14.7 0.1 0.96 9.2 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF3598 PF12204.8 AMD22070.1 - 0.08 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3598) NACHT PF05729.12 AMD22070.1 - 0.1 12.5 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 AMD22070.1 - 0.3 11.5 2.4 0.55 10.6 0.1 2.7 2 1 0 2 2 2 0 RNA helicase DUF4889 PF16230.5 AMD22070.1 - 0.72 10.1 4.1 2.3 8.5 4.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) Sec39 PF08314.11 AMD22071.1 - 1.4e-69 235.5 12.5 8.9e-54 183.2 1.9 2.1 1 1 1 2 2 2 2 Secretory pathway protein Sec39 Vps53_N PF04100.12 AMD22072.1 - 8.9e-05 21.6 1.9 8.9e-05 21.6 1.9 1.8 2 0 0 2 2 2 1 Vps53-like, N-terminal FdhE PF04216.12 AMD22072.1 - 0.046 13.6 2.1 0.076 12.9 2.1 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation COG2 PF06148.11 AMD22072.1 - 0.052 13.6 6.9 0.1 12.7 2.3 2.4 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_MLP1_2 PF07926.12 AMD22072.1 - 0.096 12.8 5.5 1.8 8.6 2.4 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Tsc35 PF15079.6 AMD22072.1 - 0.32 10.5 6.8 1.3 8.5 0.3 2.4 2 1 0 2 2 2 0 Testis-specific protein 35 THOC7 PF05615.13 AMD22072.1 - 0.46 10.8 10.4 0.3 11.3 6.2 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 AATF-Che1 PF13339.6 AMD22072.1 - 0.57 10.9 7.5 7.1 7.3 6.3 2.7 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Fib_alpha PF08702.10 AMD22072.1 - 1 9.6 8.0 2 8.6 0.1 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family LPD5 PF18799.1 AMD22072.1 - 3.3 8.1 8.8 1.1 9.7 0.4 3.2 3 1 0 3 3 3 0 Large polyvalent protein-associated domain 5 BST2 PF16716.5 AMD22072.1 - 3.6 8.2 6.3 11 6.7 2.1 2.8 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 YabA PF06156.13 AMD22072.1 - 7.8 7.2 12.2 6.3 7.5 4.7 3.3 1 1 1 2 2 2 0 Initiation control protein YabA Ribosomal_S3Ae PF01015.18 AMD22073.1 - 1.6e-85 285.7 6.5 1.9e-85 285.5 6.5 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DLP_helical PF18709.1 AMD22073.1 - 0.0047 16.2 0.4 0.007 15.6 0.4 1.3 1 0 0 1 1 1 1 Dynamin-like helical domain Abhydro_lipase PF04083.16 AMD22073.1 - 0.017 14.7 0.0 0.075 12.6 0.0 2.0 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Ras PF00071.22 AMD22074.1 - 1.1e-29 103.2 0.0 1.4e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22074.1 - 7.5e-21 74.6 0.0 2.6e-20 72.8 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD22074.1 - 9.3e-05 21.9 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD22074.1 - 0.00028 20.3 0.1 0.00037 19.9 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 AMD22074.1 - 0.00073 18.5 0.0 0.27 10.0 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) SRPRB PF09439.10 AMD22074.1 - 0.058 12.8 0.0 0.081 12.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 AMD22074.1 - 0.084 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 AMD22074.1 - 0.14 11.9 0.3 0.72 9.6 0.3 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_lid_10 PF17872.1 AMD22075.1 - 7.3e-32 109.4 0.0 1.9e-31 108.1 0.0 1.7 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 AMD22075.1 - 1.1e-19 71.2 0.0 2.4e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AMD22075.1 - 9.1e-09 35.9 0.0 3.2e-07 30.9 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AMD22075.1 - 1.5e-08 35.0 0.0 8.7e-08 32.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain BAH PF01426.18 AMD22075.1 - 9.4e-08 32.0 0.2 3.1e-07 30.3 0.2 2.0 1 0 0 1 1 1 1 BAH domain ATPase_2 PF01637.18 AMD22075.1 - 9.6e-05 22.4 0.1 9.6e-05 22.4 0.1 4.3 4 2 0 4 4 4 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 AMD22075.1 - 0.0078 16.8 0.4 0.17 12.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 AMD22075.1 - 0.023 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 AMD22075.1 - 0.026 14.6 0.2 0.37 10.8 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 AMD22075.1 - 0.058 13.7 0.4 0.15 12.4 0.4 1.7 1 1 0 1 1 1 0 AAA domain SUR7 PF06687.12 AMD22076.1 - 4.3e-07 29.8 9.1 6.5e-07 29.2 9.1 1.3 1 0 0 1 1 1 1 SUR7/PalI family Cas_Csa4 PF09703.10 AMD22076.1 - 0.014 14.7 0.1 0.021 14.1 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa4) GpcrRhopsn4 PF10192.9 AMD22077.1 - 0.0028 17.1 8.3 0.012 15.1 1.9 3.3 2 2 0 3 3 3 1 Rhodopsin-like GPCR transmembrane domain SUR7 PF06687.12 AMD22077.1 - 0.085 12.5 11.8 1.3 8.6 11.8 2.5 1 1 0 1 1 1 0 SUR7/PalI family H_PPase PF03030.16 AMD22077.1 - 0.1 11.2 0.2 0.15 10.7 0.2 1.1 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase COPIIcoated_ERV PF07970.12 AMD22078.1 - 1.7e-30 106.6 0.0 2.5e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 AMD22078.1 - 1.2e-21 76.8 0.1 3.1e-21 75.5 0.1 1.7 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF2660 PF10859.8 AMD22079.1 - 0.015 15.7 0.3 0.03 14.8 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2660) SSrecog PF03531.14 AMD22080.1 - 3.4e-30 103.8 0.6 1.3e-28 98.7 0.0 3.1 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 AMD22080.1 - 6.4e-27 93.8 2.5 3.6e-25 88.2 0.0 3.0 3 0 0 3 3 3 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 AMD22080.1 - 4.6e-26 91.1 0.0 1.3e-23 83.2 0.1 3.1 3 0 0 3 3 3 1 Histone chaperone Rttp106-like PH_TFIIH PF08567.11 AMD22080.1 - 0.016 15.5 0.2 11 6.4 0.0 3.5 3 0 0 3 3 3 0 TFIIH p62 subunit, N-terminal domain DUF4827 PF16109.5 AMD22080.1 - 0.035 14.1 0.3 0.092 12.7 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4827) LAGLIDADG_2 PF03161.13 AMD22080.1 - 0.039 14.0 1.1 0.43 10.6 0.0 2.6 3 0 0 3 3 3 0 LAGLIDADG DNA endonuclease family Dak1 PF02733.17 AMD22081.1 - 1.7e-102 342.5 0.3 2.5e-102 342.0 0.3 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 AMD22081.1 - 2e-48 164.6 0.2 3.5e-48 163.8 0.2 1.4 1 0 0 1 1 1 1 DAK2 domain BAR PF03114.18 AMD22082.1 - 4.8e-13 49.3 1.1 2.2e-12 47.2 1.1 1.9 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.6 AMD22082.1 - 3.1e-12 46.1 0.0 5.3e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AMD22082.1 - 4.8e-12 45.3 0.1 9.3e-12 44.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AMD22082.1 - 5.5e-10 38.8 0.0 9.2e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain CREPT PF16566.5 AMD22082.1 - 0.1 12.8 5.1 0.36 11.0 2.7 2.4 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour STAT_alpha PF01017.20 AMD22082.1 - 0.54 10.1 6.8 0.5 10.2 0.6 2.4 2 0 0 2 2 2 0 STAT protein, all-alpha domain THOC7 PF05615.13 AMD22082.1 - 0.68 10.2 5.6 4.4 7.6 4.4 2.6 2 1 0 2 2 2 0 Tho complex subunit 7 DASH_Dad1 PF08649.10 AMD22082.1 - 10 6.4 8.9 21 5.4 0.0 4.1 4 0 0 4 4 4 0 DASH complex subunit Dad1 Zn_clus PF00172.18 AMD22083.1 - 2.8e-06 27.3 7.7 5.5e-06 26.4 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CoA_binding_2 PF13380.6 AMD22084.1 - 1.5e-20 73.8 0.0 1.8e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain Cyt-b5 PF00173.28 AMD22085.1 - 2.8e-08 33.8 0.0 3.8e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain vATP-synt_AC39 PF01992.16 AMD22086.1 - 1.1e-104 350.6 1.5 1.2e-104 350.5 1.5 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit OspD PF03207.13 AMD22086.1 - 0.065 12.6 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) BRCT_2 PF16589.5 AMD22086.1 - 0.12 12.8 0.2 0.32 11.4 0.1 1.8 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Dor1 PF04124.12 AMD22087.1 - 1.5e-25 89.6 6.4 3.6e-25 88.4 6.4 1.5 1 1 0 1 1 1 1 Dor1-like family Sec5 PF15469.6 AMD22087.1 - 0.00062 19.6 0.7 0.0022 17.8 0.1 2.2 2 1 0 2 2 2 1 Exocyst complex component Sec5 TPR_7 PF13176.6 AMD22087.1 - 0.08 13.0 0.5 0.74 10.0 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat C2 PF00168.30 AMD22088.1 - 5.6e-51 171.1 0.2 6.6e-18 64.9 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 AMD22088.1 - 0.0024 17.4 0.1 0.17 11.3 0.0 2.6 2 0 0 2 2 2 2 Synaptotagmin-like mitochondrial-lipid-binding domain Ribosomal_L6e PF01159.19 AMD22089.1 - 1.7e-38 131.6 0.6 2.2e-38 131.2 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e FKBP_C PF00254.28 AMD22090.1 - 4.5e-28 97.4 0.1 4.5e-28 97.4 0.1 2.3 3 1 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 AMD22090.1 - 1e-22 80.6 5.2 1e-22 80.6 5.2 3.0 2 2 0 2 2 2 1 Nucleoplasmin-like domain YL1 PF05764.13 AMD22090.1 - 0.00013 22.1 23.5 0.00013 22.1 23.5 2.6 2 1 0 2 2 2 1 YL1 nuclear protein HMG-CoA_red PF00368.18 AMD22091.1 - 5.4e-141 469.8 0.1 7.7e-141 469.3 0.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 AMD22091.1 - 4e-35 121.0 3.5 4e-35 121.0 3.5 2.2 2 0 0 2 2 2 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 AMD22091.1 - 1.6e-06 28.0 8.6 1.6e-06 28.0 8.6 1.8 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Sybindin PF04099.12 AMD22092.1 - 7.8e-21 74.5 0.2 1e-20 74.2 0.2 1.1 1 0 0 1 1 1 1 Sybindin-like family ENTH PF01417.20 AMD22093.1 - 5.3e-45 152.5 0.1 8.7e-45 151.8 0.1 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 AMD22093.1 - 0.00084 18.4 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 AMD22093.1 - 0.0012 18.7 0.1 0.0021 17.9 0.1 1.3 1 0 0 1 1 1 1 VHS domain Pro_isomerase PF00160.21 AMD22094.1 - 7.1e-49 166.1 0.1 8.3e-49 165.9 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TFR_dimer PF04253.15 AMD22095.1 - 3e-16 59.6 0.0 1.5e-15 57.3 0.0 2.0 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 AMD22095.1 - 1.2e-13 51.2 0.0 1.9e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 AMD22095.1 - 3.9e-08 33.2 0.0 1.4e-07 31.4 0.0 1.9 2 0 0 2 2 2 1 PA domain Dus PF01207.17 AMD22096.1 - 6.6e-80 268.5 0.0 8.4e-80 268.2 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DMPK_coil PF08826.10 AMD22097.1 - 0.012 15.7 3.5 0.012 15.7 3.5 2.4 3 0 0 3 3 3 0 DMPK coiled coil domain like Hormone_1 PF00103.20 AMD22097.1 - 0.014 15.2 1.0 0.026 14.3 0.5 1.6 1 1 1 2 2 2 0 Somatotropin hormone family SIKE PF05769.11 AMD22097.1 - 0.24 11.3 0.1 0.24 11.3 0.1 2.5 2 1 0 2 2 2 0 SIKE family CorA PF01544.18 AMD22097.1 - 0.72 9.1 5.6 6.8 5.9 3.1 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein YabA PF06156.13 AMD22097.1 - 0.87 10.3 5.9 20 5.9 0.0 3.0 2 1 1 3 3 3 0 Initiation control protein YabA DUF4407 PF14362.6 AMD22097.1 - 1.3 8.3 4.9 11 5.2 4.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 AMD22097.1 - 1.3 8.5 5.4 2.1 7.8 4.5 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit Uso1_p115_C PF04871.13 AMD22097.1 - 1.8 8.9 10.9 1.4 9.3 6.8 2.2 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF745 PF05335.13 AMD22097.1 - 2.7 7.7 6.4 1.1 9.0 1.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) PRKG1_interact PF15898.5 AMD22097.1 - 3.3 8.7 10.2 26 5.8 7.3 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4200 PF13863.6 AMD22097.1 - 4.3 7.8 14.6 0.35 11.3 5.8 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Methyltransf_16 PF10294.9 AMD22098.1 - 8.6e-20 71.2 0.0 1.3e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 AMD22098.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AMD22098.1 - 0.018 15.7 0.0 0.028 15.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 AMD22098.1 - 0.024 15.4 0.0 0.041 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF166 PF02593.14 AMD22098.1 - 0.044 13.3 0.0 0.072 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function PrmA PF06325.13 AMD22098.1 - 0.21 10.9 0.0 0.29 10.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ATP-synt_J PF04911.12 AMD22099.1 - 5.2e-28 96.4 0.4 5.8e-28 96.2 0.4 1.0 1 0 0 1 1 1 1 ATP synthase j chain Cys_Met_Meta_PP PF01053.20 AMD22100.1 - 6.4e-26 90.8 0.0 1.1e-24 86.7 0.0 2.2 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme DUF4107 PF13389.6 AMD22100.1 - 0.16 12.1 0.1 4.7 7.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4107) Glyco_hydro_47 PF01532.20 AMD22101.1 - 2.5e-139 465.1 2.3 2.8e-139 464.9 2.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 AMD22101.1 - 0.00031 20.4 0.5 0.25 10.8 0.0 3.2 3 0 0 3 3 3 2 Glycosyl hydrolase family 76 DUF1563 PF07599.11 AMD22101.1 - 0.43 10.7 7.4 0.091 12.9 2.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) Ctf8 PF09696.10 AMD22102.1 - 3.7e-14 53.3 0.9 1.5e-11 44.9 0.9 2.1 1 1 0 1 1 1 1 Ctf8 zinc_ribbon_10 PF10058.9 AMD22103.1 - 2.8e-10 39.8 1.2 4.3e-10 39.2 0.6 1.6 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein DUF3810 PF12725.7 AMD22103.1 - 0.002 17.6 0.4 0.0031 16.9 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3810) Lipocalin_8 PF16585.5 AMD22103.1 - 0.056 13.9 1.7 0.5 10.8 0.0 2.2 2 0 0 2 2 2 0 Lipocalin-like domain YtpI PF14007.6 AMD22103.1 - 0.079 13.1 0.6 0.15 12.2 0.6 1.4 1 0 0 1 1 1 0 YtpI-like protein SLATT_5 PF18160.1 AMD22103.1 - 0.1 11.9 3.2 1 8.6 0.3 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Matrilin_ccoil PF10393.9 AMD22103.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin Tup_N PF08581.10 AMD22103.1 - 0.13 12.5 5.3 4 7.8 4.0 2.4 2 1 0 2 2 2 0 Tup N-terminal Prefoldin_2 PF01920.20 AMD22103.1 - 0.32 11.0 6.4 4.5 7.3 0.0 2.9 2 1 0 2 2 2 0 Prefoldin subunit Csm1_N PF18504.1 AMD22103.1 - 0.37 11.2 6.4 0.18 12.1 1.1 2.7 3 0 0 3 3 3 0 Csm1 N-terminal domain DASH_Duo1 PF08651.10 AMD22103.1 - 0.54 10.1 5.8 1.3 8.9 0.4 2.8 2 1 1 3 3 3 0 DASH complex subunit Duo1 NAC PF01849.18 AMD22104.1 - 6.5e-20 70.9 0.5 4.4e-19 68.2 0.3 2.1 2 0 0 2 2 2 1 NAC domain MRI PF15325.6 AMD22104.1 - 1.2 10.2 6.0 0.7 11.0 3.4 1.8 1 1 1 2 2 2 0 Modulator of retrovirus infection MDM31_MDM32 PF08118.11 AMD22105.1 - 1.7e-217 723.3 1.7 1.4e-216 720.3 1.7 1.9 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins GDPD_2 PF13653.6 AMD22105.1 - 0.047 14.2 0.1 0.55 10.8 0.0 2.6 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family IBN_N PF03810.19 AMD22107.1 - 2.8e-19 68.8 0.1 2.1e-16 59.6 0.0 4.0 4 0 0 4 4 4 2 Importin-beta N-terminal domain Cse1 PF08506.10 AMD22107.1 - 2.9e-05 23.1 0.1 8.4e-05 21.5 0.1 1.9 1 0 0 1 1 1 1 Cse1 Penicil_amidase PF01804.18 AMD22107.1 - 0.29 10.0 0.0 0.53 9.2 0.0 1.3 1 0 0 1 1 1 0 Penicillin amidase DUF3479 PF11965.8 AMD22108.1 - 0.074 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) DUF212 PF02681.14 AMD22108.1 - 0.082 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Divergent PAP2 family ERG4_ERG24 PF01222.17 AMD22109.1 - 7.4e-155 515.9 14.0 8.3e-155 515.8 14.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 AMD22109.1 - 0.0044 16.6 0.4 0.0044 16.6 0.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) Aha1_N PF09229.11 AMD22110.1 - 6.2e-27 94.5 1.0 7.5e-27 94.2 1.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal RNase_P_pop3 PF08228.11 AMD22111.1 - 8.7e-49 165.6 0.1 1e-48 165.4 0.1 1.0 1 0 0 1 1 1 1 RNase P subunit Pop3 CsgA PF17334.2 AMD22111.1 - 0.2 12.4 0.0 0.29 11.9 0.0 1.2 1 0 0 1 1 1 0 Minor curli fiber component A WSC PF01822.19 AMD22112.1 - 1.4e-08 34.8 8.5 1.4e-08 34.8 8.5 2.1 2 0 0 2 2 2 1 WSC domain SKG6 PF08693.10 AMD22112.1 - 0.019 14.4 1.5 0.08 12.4 1.5 2.2 1 0 0 1 1 1 0 Transmembrane alpha-helix domain SWI-SNF_Ssr4 PF08549.10 AMD22112.1 - 4.2 5.9 9.0 6.1 5.3 9.0 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SRP-alpha_N PF04086.13 AMD22112.1 - 8.2 6.3 8.7 13 5.6 8.7 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOG2 PF10428.9 AMD22112.1 - 8.6 5.4 28.8 0.43 9.7 23.6 1.4 2 0 0 2 2 2 0 RAM signalling pathway protein Ribosomal_L27A PF00828.19 AMD22113.1 - 2.4e-32 112.3 1.2 2.4e-32 112.3 1.2 1.5 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF1751 PF08551.10 AMD22114.1 - 4e-27 94.7 3.0 4e-27 94.7 3.0 2.2 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) RDD PF06271.12 AMD22114.1 - 7.7 6.7 14.8 0.19 11.9 2.6 3.0 3 0 0 3 3 3 0 RDD family HLH PF00010.26 AMD22115.1 - 0.00037 20.4 0.1 0.00088 19.2 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PLC-beta_C PF08703.10 AMD22115.1 - 0.0035 17.3 1.1 0.0037 17.3 1.1 1.1 1 0 0 1 1 1 1 PLC-beta C terminal CSG2 PF16965.5 AMD22116.1 - 5e-61 206.8 24.7 2.5e-60 204.5 19.1 2.1 1 1 1 2 2 2 2 Ceramide synthase regulator ADH_zinc_N PF00107.26 AMD22117.1 - 3.7e-08 33.4 0.0 6.1e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Mannosyl_trans3 PF11051.8 AMD22118.1 - 2.2e-40 138.8 0.0 4.5e-40 137.8 0.0 1.5 1 0 0 1 1 1 1 Mannosyltransferase putative DUF1645 PF07816.11 AMD22119.1 - 0.053 14.1 5.4 0.082 13.5 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) SR-25 PF10500.9 AMD22119.1 - 0.31 10.6 12.3 0.59 9.7 12.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 AMD22120.1 - 2.4e-61 207.4 0.0 7e-61 205.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22120.1 - 6.8e-32 110.8 0.0 1.6e-31 109.6 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 AMD22120.1 - 0.00061 20.4 2.0 0.0019 18.9 2.0 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 AMD22120.1 - 0.032 13.5 0.0 0.2 10.9 0.0 2.0 2 0 0 2 2 2 0 Kinase-like CTP_transf_1 PF01148.20 AMD22121.1 - 4.3e-78 262.7 19.5 6e-78 262.3 19.5 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family SdpI PF13630.6 AMD22121.1 - 5.7 7.2 15.1 13 6.0 1.4 3.3 2 1 0 2 2 2 0 SdpI/YhfL protein family DUF3449 PF11931.8 AMD22122.1 - 1.6e-64 217.1 0.0 6e-63 212.0 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) PRP9_N PF16958.5 AMD22122.1 - 1e-45 155.5 8.6 1.2e-45 155.2 6.5 2.2 2 0 0 2 2 2 1 Pre-mRNA-splicing factor PRP9 N-terminus SF3A3 PF16837.5 AMD22122.1 - 7.8e-18 64.8 1.0 7.8e-18 64.8 1.0 2.7 2 1 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 AMD22122.1 - 6.7e-08 32.7 1.8 8.5e-05 22.8 0.1 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD22122.1 - 1.2e-06 28.7 7.1 2.5e-05 24.4 0.0 3.5 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AMD22122.1 - 0.00029 21.1 3.4 0.063 13.6 0.0 3.2 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) DUF2175 PF09943.9 AMD22122.1 - 0.2 12.0 8.8 2.7 8.3 0.1 3.5 3 2 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) zf-C2H2 PF00096.26 AMD22122.1 - 0.52 10.9 2.5 12 6.6 0.1 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22122.1 - 0.84 10.6 3.6 24 6.1 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DEAD PF00270.29 AMD22123.1 - 1.1e-50 171.8 0.1 6.7e-49 166.0 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22123.1 - 5.4e-23 81.4 1.2 8.7e-21 74.4 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 AMD22123.1 - 1.2e-18 67.1 5.0 1.2e-18 67.1 5.0 2.8 3 0 0 3 3 3 1 DBP10CT (NUC160) domain ResIII PF04851.15 AMD22123.1 - 2.3e-07 31.0 0.0 7.7e-07 29.3 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AMD22123.1 - 0.0014 17.9 0.6 0.0073 15.5 0.0 2.5 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase Glyco_hydro_1 PF00232.18 AMD22123.1 - 0.036 12.5 0.0 0.07 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 DUF2829 PF11195.8 AMD22123.1 - 0.05 13.9 0.0 0.21 11.8 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2829) tRNA_Me_trans PF03054.16 AMD22124.1 - 5.7e-113 377.3 0.0 6.5e-113 377.1 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 AMD22124.1 - 0.0017 17.5 0.0 0.033 13.3 0.0 2.1 2 0 0 2 2 2 1 NAD synthase Inositol_P PF00459.25 AMD22125.1 - 2e-51 175.1 0.0 4.4e-51 174.0 0.0 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family Git3 PF11710.8 AMD22126.1 - 1.8e-73 246.7 10.6 3.3e-73 245.8 10.6 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 AMD22126.1 - 3.9e-34 116.6 3.2 1.2e-33 115.0 3.2 1.9 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Exo_endo_phos PF03372.23 AMD22127.1 - 1.7e-05 24.4 0.0 3.3e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Inv-AAD PF18785.1 AMD22128.1 - 1.1e-35 122.3 0.0 2e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase PseudoU_synth_2 PF00849.22 AMD22128.1 - 2e-33 115.7 0.0 3.9e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.23 AMD22128.1 - 2.9e-19 68.8 0.0 5.1e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AMD22128.1 - 1.1e-07 31.7 0.0 2.2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 MafB19-like deaminase S4 PF01479.25 AMD22128.1 - 0.038 13.7 0.0 0.56 10.0 0.0 2.7 2 0 0 2 2 2 0 S4 domain NARP1 PF12569.8 AMD22129.1 - 1.1e-109 367.7 26.2 3.5e-77 260.5 5.8 3.6 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 AMD22129.1 - 2.7e-12 45.8 15.2 0.057 13.6 0.1 8.8 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 AMD22129.1 - 2.6e-11 43.4 0.8 0.013 16.3 0.0 7.3 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 AMD22129.1 - 3.1e-09 37.3 0.0 0.12 13.1 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 AMD22129.1 - 1.5e-08 34.5 0.8 0.11 12.9 0.0 5.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 AMD22129.1 - 1e-07 32.3 4.9 0.38 11.3 0.1 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD22129.1 - 2.1e-07 31.1 14.0 0.00018 21.6 0.1 5.3 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AMD22129.1 - 2.2e-07 30.5 11.7 0.39 11.0 0.0 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 AMD22129.1 - 7.6e-06 25.5 19.2 0.06 13.2 0.1 8.4 10 0 0 10 10 10 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AMD22129.1 - 0.00016 21.7 6.1 0.63 10.2 0.3 3.9 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 AMD22129.1 - 0.00026 21.2 2.7 5.4 7.4 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 AMD22129.1 - 0.017 15.1 0.6 14 6.0 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 AMD22129.1 - 0.032 13.9 0.0 0.68 9.7 0.0 3.2 3 0 0 3 3 3 0 TPR repeat TPR_10 PF13374.6 AMD22129.1 - 0.11 12.4 0.2 28 4.8 0.0 4.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 AMD22129.1 - 0.53 11.0 15.3 1.1 10.1 0.1 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat ABC2_membrane PF01061.24 AMD22130.1 - 8.7e-62 208.3 57.1 9.4e-37 126.5 16.9 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 AMD22130.1 - 1.2e-41 142.4 0.1 3.8e-20 72.8 0.0 3.6 4 0 0 4 4 3 2 ABC transporter PDR_CDR PF06422.12 AMD22130.1 - 7.7e-38 128.3 8.4 4.5e-33 113.0 0.0 3.3 3 0 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 AMD22130.1 - 6e-08 32.2 48.3 0.0011 18.2 21.1 3.4 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 AMD22130.1 - 1.3e-06 28.9 0.0 2.9e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 AMD22130.1 - 2.6e-06 27.9 0.1 0.011 16.2 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 AMD22130.1 - 3e-05 24.0 0.1 0.00051 20.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 AMD22130.1 - 0.00029 20.4 0.0 0.1 12.0 0.0 3.4 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 AMD22130.1 - 0.00039 20.5 0.1 0.14 12.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 AMD22130.1 - 0.00061 19.5 0.1 0.22 11.3 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 AMD22130.1 - 0.0012 18.7 0.0 0.99 9.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 AMD22130.1 - 0.0022 18.3 0.1 0.02 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 AMD22130.1 - 0.003 17.2 0.2 0.039 13.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 AMD22130.1 - 0.0078 15.8 0.3 0.018 14.6 0.1 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 AMD22130.1 - 0.021 15.4 0.0 0.22 12.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AMD22130.1 - 0.033 14.1 0.1 0.49 10.3 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 AMD22130.1 - 0.11 12.3 0.1 2.3 7.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AMD22130.1 - 0.16 12.1 0.2 1.4 9.0 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 AMD22130.1 - 0.17 12.1 0.2 0.43 10.8 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AMD22130.1 - 0.23 11.9 2.6 0.57 10.6 0.3 2.2 2 0 0 2 2 2 0 AAA domain Hid1 PF12722.7 AMD22131.1 - 4.1e-77 260.1 17.6 3.7e-52 177.5 1.8 2.8 3 1 0 3 3 3 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 AMD22131.1 - 1.9e-22 79.5 14.0 2.6e-21 75.8 2.0 3.4 3 1 0 3 3 3 2 Dyggve-Melchior-Clausen syndrome protein WGG PF10273.9 AMD22132.1 - 5.3e-28 97.5 0.7 5.3e-28 97.5 0.7 1.9 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 Metallophos PF00149.28 AMD22133.1 - 4.4e-38 131.8 0.0 6.8e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase IMPDH PF00478.25 AMD22134.1 - 7.8e-139 462.5 4.4 9e-139 462.3 4.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 AMD22134.1 - 3.2e-13 49.9 0.1 4.5e-06 27.0 0.0 2.6 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 AMD22134.1 - 3.1e-09 36.3 0.6 6.4e-09 35.3 0.6 1.5 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 AMD22134.1 - 2.4e-06 27.2 9.4 0.022 14.2 5.8 2.5 2 1 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 AMD22134.1 - 5.3e-05 22.8 1.6 0.0024 17.4 0.3 2.4 1 1 1 2 2 2 1 Histidine biosynthesis protein Aldolase PF01081.19 AMD22134.1 - 0.003 17.0 0.5 0.013 14.9 0.1 2.2 2 0 0 2 2 2 1 KDPG and KHG aldolase PcrB PF01884.17 AMD22134.1 - 0.017 14.6 2.6 5.6 6.3 0.1 3.6 3 1 0 4 4 4 0 PcrB family ThiG PF05690.14 AMD22134.1 - 0.021 14.1 1.3 0.039 13.3 0.9 1.7 1 1 0 1 1 1 0 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 AMD22134.1 - 0.13 11.5 0.6 5.9 6.2 0.0 3.0 2 1 1 3 3 3 0 Thiamine monophosphate synthase SUR7 PF06687.12 AMD22135.1 - 1.7e-06 27.8 23.6 5.6e-06 26.1 20.1 2.5 2 1 0 2 2 2 2 SUR7/PalI family SNARE PF05739.19 AMD22136.1 - 1.6e-15 56.8 0.2 3e-15 55.9 0.2 1.5 1 0 0 1 1 1 1 SNARE domain TMPIT PF07851.13 AMD22136.1 - 0.0053 16.1 0.9 0.0053 16.1 0.9 1.8 2 0 0 2 2 2 1 TMPIT-like protein Scaffolding_pro PF11418.8 AMD22136.1 - 0.0075 16.8 0.0 0.024 15.2 0.0 1.9 1 0 0 1 1 1 1 Phi29 scaffolding protein KASH PF10541.9 AMD22136.1 - 0.048 13.9 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Nuclear envelope localisation domain SEO_N PF14576.6 AMD22136.1 - 0.063 12.4 1.5 0.84 8.7 0.1 2.1 2 0 0 2 2 2 0 Sieve element occlusion N-terminus DUF2615 PF11027.8 AMD22136.1 - 0.064 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) DUF3357 PF11837.8 AMD22136.1 - 0.087 13.3 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Zot PF05707.12 AMD22136.1 - 0.11 12.1 0.2 0.16 11.6 0.2 1.2 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) GRA6 PF05084.13 AMD22136.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Granule antigen protein (GRA6) DSPn PF14671.6 AMD22137.1 - 4.9e-45 153.4 0.1 1.3e-44 152.1 0.0 1.8 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 AMD22137.1 - 5.8e-24 84.4 0.0 7.2e-22 77.6 0.0 2.7 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AMD22137.1 - 0.00033 20.3 0.0 0.0008 19.0 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 AMD22137.1 - 0.0026 17.5 0.1 0.0053 16.4 0.1 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 AMD22137.1 - 0.06 13.5 0.0 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 Inositol hexakisphosphate Acetyltransf_13 PF13880.6 AMD22138.1 - 2.1e-21 75.6 0.2 3.9e-21 74.8 0.2 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 AMD22138.1 - 2.2e-08 33.8 0.1 3.6e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.25 AMD22138.1 - 0.00091 19.5 0.0 0.0019 18.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AMD22138.1 - 0.0029 18.0 0.0 0.018 15.5 0.0 2.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AMD22138.1 - 0.13 12.2 0.0 0.7 9.8 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Zn_ribbon_recom PF13408.6 AMD22138.1 - 0.15 12.6 0.7 12 6.5 0.2 2.5 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain PHP PF02811.19 AMD22139.1 - 3.8e-09 37.1 0.9 9.6e-09 35.8 0.7 1.7 2 1 0 2 2 2 1 PHP domain ProRS-C_1 PF09180.11 AMD22140.1 - 2.1e-26 91.9 1.2 4.3e-26 90.9 1.2 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 AMD22140.1 - 4.4e-21 74.8 0.1 4.1e-20 71.7 0.0 2.6 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AMD22140.1 - 2e-14 53.9 0.0 3.6e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 AMD22140.1 - 0.068 13.2 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain tRNA-synt_2 PF00152.20 AMD22141.1 - 2.2e-88 296.4 0.0 3.4e-88 295.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AMD22141.1 - 2.2e-11 43.6 0.0 4.5e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.11 AMD22141.1 - 0.0084 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Lyase_1 PF00206.20 AMD22142.1 - 6.5e-98 328.0 0.0 9.2e-98 327.5 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 AMD22142.1 - 8.7e-23 80.9 0.0 1.8e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal T4_Rnl2_C PF18043.1 AMD22142.1 - 0.099 12.8 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal DUF1776 PF08643.10 AMD22143.1 - 2.3e-70 237.3 0.1 4.1e-70 236.5 0.1 1.4 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Ysc84 PF04366.12 AMD22144.1 - 6.8e-42 142.2 1.0 1.1e-41 141.5 1.0 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 AMD22144.1 - 1.3e-12 47.1 0.0 2.8e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AMD22144.1 - 7.6e-12 44.9 0.0 1.5e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AMD22144.1 - 3.8e-11 42.5 0.1 1.4e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain RRM_1 PF00076.22 AMD22145.1 - 2.1e-47 158.8 7.9 1.6e-17 63.1 0.6 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AMD22145.1 - 0.0002 21.3 0.5 1 9.5 0.1 3.7 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 AMD22145.1 - 0.0033 17.4 0.1 7.7 6.6 0.0 3.3 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Pes-10 PF07149.11 AMD22145.1 - 0.0043 16.2 1.6 0.0079 15.3 1.6 1.3 1 0 0 1 1 1 1 Pes-10 Limkain-b1 PF11608.8 AMD22145.1 - 0.033 14.3 0.3 28 4.9 0.0 3.7 3 1 0 3 3 3 0 Limkain b1 RRM_7 PF16367.5 AMD22145.1 - 0.11 12.6 0.1 1.6 8.9 0.0 2.9 3 1 0 3 3 3 0 RNA recognition motif Pkinase PF00069.25 AMD22146.1 - 7.9e-47 159.8 0.0 1.7e-46 158.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22146.1 - 9.9e-24 84.0 0.0 1.5e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD22146.1 - 0.0026 17.1 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AMD22146.1 - 0.044 13.7 0.0 0.098 12.6 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 AMD22146.1 - 0.066 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AMD22146.1 - 0.068 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase CDtoxinA PF03498.14 AMD22146.1 - 0.081 12.5 0.1 15 5.1 0.0 2.3 2 0 0 2 2 2 0 Cytolethal distending toxin A/C domain GET2 PF08690.10 AMD22146.1 - 0.083 12.6 2.3 0.2 11.3 2.3 1.5 1 1 0 1 1 1 0 GET complex subunit GET2 Sterol-sensing PF12349.8 AMD22147.1 - 0.012 15.4 1.8 0.012 15.4 1.8 2.1 2 0 0 2 2 2 0 Sterol-sensing domain of SREBP cleavage-activation Vps16_N PF04841.13 AMD22147.1 - 0.13 11.0 0.0 0.35 9.6 0.0 1.6 2 0 0 2 2 2 0 Vps16, N-terminal region BAR PF03114.18 AMD22148.1 - 1.3e-53 182.1 0.8 1.7e-53 181.7 0.8 1.1 1 0 0 1 1 1 1 BAR domain Jnk-SapK_ap_N PF09744.9 AMD22148.1 - 0.013 15.7 0.3 0.013 15.7 0.3 2.5 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 MgtE_N PF03448.17 AMD22148.1 - 0.017 15.7 0.9 1.1 9.8 0.1 3.3 3 1 0 3 3 3 0 MgtE intracellular N domain DUF2303 PF10065.9 AMD22148.1 - 0.03 13.5 0.1 0.039 13.1 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) NADH_4Fe-4S PF10589.9 AMD22148.1 - 0.085 12.9 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region DUF2313 PF10076.9 AMD22148.1 - 0.1 12.4 0.5 0.23 11.3 0.0 1.9 3 0 0 3 3 3 0 Uncharacterised protein conserved in bacteria (DUF2313) DUF4164 PF13747.6 AMD22148.1 - 2.3 8.5 7.6 0.42 10.9 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) Gpr1_Fun34_YaaH PF01184.19 AMD22149.1 - 8e-91 303.2 19.2 9.4e-91 303.0 19.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family RNA_pol_Rpc34 PF05158.12 AMD22150.1 - 1e-107 360.4 1.8 1.3e-107 360.1 1.8 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit LSM14 PF12701.7 AMD22150.1 - 0.0041 17.2 0.0 0.028 14.5 0.0 2.3 2 0 0 2 2 2 1 Scd6-like Sm domain Rrf2 PF02082.20 AMD22150.1 - 0.042 14.2 0.1 0.09 13.1 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator RPA_C PF08784.11 AMD22150.1 - 0.11 13.2 0.3 0.49 11.1 0.1 2.3 2 2 0 2 2 2 0 Replication protein A C terminal B-block_TFIIIC PF04182.12 AMD22150.1 - 0.17 12.1 1.1 0.49 10.6 0.2 2.0 1 1 1 2 2 2 0 B-block binding subunit of TFIIIC ABC2_membrane PF01061.24 AMD22151.1 - 3.4e-37 127.9 15.6 3.4e-37 127.9 15.6 2.4 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.27 AMD22151.1 - 3.8e-26 92.2 0.0 6.6e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 AMD22151.1 - 0.00031 20.7 0.1 0.0007 19.5 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 AMD22151.1 - 0.0043 16.5 0.0 0.01 15.3 0.0 1.6 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 AMD22151.1 - 0.011 15.7 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_21 PF13304.6 AMD22151.1 - 0.016 15.0 1.5 0.97 9.2 0.3 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 AMD22151.1 - 0.045 14.0 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AMD22151.1 - 0.12 12.1 0.6 0.33 10.7 0.2 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Laminin_EGF PF00053.24 AMD22151.1 - 5 7.3 34.1 0.079 13.1 7.6 3.8 2 2 1 3 3 2 0 Laminin EGF domain EGF_2 PF07974.13 AMD22151.1 - 6.1 7.3 34.5 0.072 13.5 1.6 4.2 5 0 0 5 5 5 0 EGF-like domain ABC2_membrane_3 PF12698.7 AMD22151.1 - 7.6 5.5 31.6 1.8 7.6 27.5 1.9 2 1 0 2 2 2 0 ABC-2 family transporter protein Peptidase_M28 PF04389.17 AMD22152.1 - 1.1e-40 139.5 0.0 1.7e-40 138.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PIP5K PF01504.18 AMD22153.1 - 2e-39 135.5 0.9 1.1e-33 116.7 0.5 4.4 6 1 1 7 7 7 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 AMD22153.1 - 2e-25 89.4 0.0 3.5e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 AMD22153.1 - 5.6e-17 61.7 12.5 5.6e-17 61.7 12.5 3.5 4 1 0 4 4 4 1 FYVE zinc finger DUF3391 PF11871.8 AMD22153.1 - 9.2 6.8 7.6 0.5 10.9 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) WD40 PF00400.32 AMD22154.1 - 2.7e-08 34.3 0.0 0.0079 17.0 0.0 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22154.1 - 8.5e-07 29.2 0.0 0.02 15.1 0.0 3.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AMD22154.1 - 0.07 12.1 0.1 0.27 10.2 0.0 1.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Arrestin_C PF02752.22 AMD22155.1 - 3.2e-13 50.3 0.0 1.1e-12 48.6 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 AMD22155.1 - 3.4e-05 23.6 0.0 9.1e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 AMD22155.1 - 6.9e-05 22.9 0.0 0.00074 19.6 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Glyco_hydro_16 PF00722.21 AMD22156.1 - 3.4e-48 163.4 2.3 5.6e-48 162.7 2.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SR-25 PF10500.9 AMD22156.1 - 0.026 14.2 6.1 0.043 13.4 6.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNA_pol_Rpb4 PF03874.16 AMD22157.1 - 4.1e-28 98.2 0.4 4.9e-28 97.9 0.4 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Herpes_LAMP2 PF06126.11 AMD22157.1 - 0.043 12.4 0.0 0.055 12.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 Mad3_BUB1_I PF08311.12 AMD22158.1 - 4.1e-40 136.6 1.2 4.1e-40 136.6 1.2 2.0 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 AMD22158.1 - 8.7e-26 89.9 0.2 2.5e-24 85.2 0.0 2.8 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 AMD22158.1 - 3.7e-18 65.8 0.0 6.8e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_I_2 PF17014.5 AMD22158.1 - 7.6e-05 22.8 2.2 0.00031 20.9 0.5 2.7 3 0 0 3 3 3 1 Putative Mad3/BUB1 like region 1 protein Pkinase_Tyr PF07714.17 AMD22158.1 - 0.00017 21.0 0.0 0.00034 20.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD22158.1 - 0.015 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Cpn60_TCP1 PF00118.24 AMD22159.1 - 1.2e-162 542.0 2.6 1.4e-162 541.8 2.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF4288 PF14119.6 AMD22160.1 - 0.017 15.5 0.1 0.025 15.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) Sad1_UNC PF07738.13 AMD22162.1 - 1.2e-08 35.1 0.2 2.9e-08 33.8 0.2 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Spore_GerAC PF05504.11 AMD22162.1 - 0.51 10.6 5.1 0.22 11.8 1.5 2.2 2 0 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal DUF3835 PF12927.7 AMD22162.1 - 8.7 7.3 7.8 48 4.9 5.9 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3835) Bot1p PF12298.8 AMD22163.1 - 2.5e-51 174.3 0.4 3.4e-51 173.8 0.4 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein Trs65 PF12735.7 AMD22164.1 - 7.7e-27 94.5 1.6 1.5e-14 54.1 0.0 2.6 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 Clathrin_lg_ch PF01086.17 AMD22165.1 - 3.4e-36 125.4 13.0 3.8e-36 125.3 13.0 1.0 1 0 0 1 1 1 1 Clathrin light chain PulA_N1 PF17999.1 AMD22165.1 - 0.0064 17.2 1.6 0.01 16.6 1.6 1.4 1 0 0 1 1 1 1 Pullulanase N1-terminal domain Phosducin PF02114.16 AMD22165.1 - 0.017 14.1 4.8 0.018 14.0 4.8 1.2 1 0 0 1 1 1 0 Phosducin DUF3507 PF12015.8 AMD22165.1 - 0.056 13.1 1.1 0.094 12.4 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) DUF3523 PF12037.8 AMD22165.1 - 0.059 12.7 12.1 0.066 12.6 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) RRP14 PF15459.6 AMD22165.1 - 5.5 7.7 10.6 0.89 10.2 0.6 2.7 2 1 1 3 3 3 0 60S ribosome biogenesis protein Rrp14 FKBP_N PF01346.18 AMD22165.1 - 8.5 7.4 11.3 5 8.1 7.8 2.0 1 1 1 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase SH3_1 PF00018.28 AMD22167.1 - 3e-05 23.5 1.4 3.7e-05 23.2 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 AMD22167.1 - 0.00017 21.2 0.2 0.00071 19.2 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 AMD22167.1 - 0.0099 15.7 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PseudoU_synth_2 PF00849.22 AMD22168.1 - 2.9e-31 108.7 0.0 4.5e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF3915 PF13054.6 AMD22169.1 - 0.041 13.9 0.5 0.11 12.4 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) FSH1 PF03959.13 AMD22170.1 - 1.1e-57 195.1 0.0 1.3e-57 194.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 AMD22170.1 - 0.00062 19.8 0.2 0.041 13.8 0.0 2.2 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 AMD22170.1 - 0.012 15.5 1.7 5 6.9 1.0 2.6 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 AMD22170.1 - 0.022 14.8 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain dCMP_cyt_deam_1 PF00383.23 AMD22171.1 - 1.8e-23 82.3 0.4 2.6e-23 81.8 0.4 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AMD22171.1 - 1.3e-18 67.1 0.0 1.9e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 AMD22171.1 - 7.3e-05 22.9 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 AMD22171.1 - 0.00019 21.6 0.0 0.00036 20.7 0.0 1.4 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 AMD22171.1 - 0.00021 21.3 0.0 0.00036 20.5 0.0 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC2 PF18772.1 AMD22171.1 - 0.0012 18.9 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 APOBEC2 Bd3614-deam PF14439.6 AMD22171.1 - 0.0054 16.8 0.4 0.045 13.8 0.4 2.2 1 1 0 1 1 1 1 Bd3614-like deaminase XOO_2897-deam PF14440.6 AMD22171.1 - 0.0064 16.6 0.0 0.024 14.7 0.0 1.9 1 1 1 2 2 2 1 Xanthomonas XOO_2897-like deaminase APOBEC3 PF18771.1 AMD22171.1 - 0.0093 16.1 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 APOBEC3 Inv-AAD PF18785.1 AMD22171.1 - 0.02 14.7 0.1 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase Toxin-deaminase PF14424.6 AMD22171.1 - 0.029 14.5 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases APOBEC4_like PF18774.1 AMD22171.1 - 0.079 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase PX PF00787.24 AMD22172.1 - 1.1e-22 80.1 0.0 2.9e-22 78.8 0.0 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 AMD22172.1 - 0.003 17.1 15.4 8.4 5.9 15.4 2.5 1 1 0 1 1 1 1 Vps5 C terminal like Gp-FAR-1 PF05823.12 AMD22172.1 - 0.0052 17.1 1.6 0.0052 17.1 1.6 2.5 1 1 0 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DASH_Dam1 PF08653.10 AMD22172.1 - 0.057 13.2 0.8 2.3 8.1 0.1 3.0 2 0 0 2 2 2 0 DASH complex subunit Dam1 Vac_Fusion PF02346.16 AMD22172.1 - 2.5 7.8 6.0 13 5.5 0.1 3.8 5 0 0 5 5 5 0 Chordopoxvirus multifunctional envelope protein A27 UPF0242 PF06785.11 AMD22172.1 - 4.3 7.4 11.3 1.6 8.8 3.5 2.4 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DPPIV_N PF00930.21 AMD22173.1 - 1.7e-90 303.3 3.3 2.6e-90 302.8 3.3 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 AMD22173.1 - 1.2e-51 175.2 1.8 3.4e-51 173.7 0.7 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 AMD22173.1 - 0.00022 21.9 0.0 0.00088 19.9 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.12 AMD22173.1 - 0.02 13.6 0.0 0.15 10.7 0.0 2.2 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) RPN1_RPN2_N PF17781.1 AMD22174.1 - 1.8e-113 379.0 2.0 3.4e-113 378.1 2.0 1.5 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 AMD22174.1 - 1.2e-28 98.9 0.1 2.4e-28 97.9 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 AMD22174.1 - 9.5e-24 82.6 12.5 2.6e-05 24.4 0.2 8.4 9 0 0 9 9 9 5 Proteasome/cyclosome repeat COMPASS-Shg1 PF05205.12 AMD22174.1 - 0.5 11.1 4.3 3.2 8.5 0.1 3.0 3 0 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 Allexi_40kDa PF05549.11 AMD22174.1 - 0.72 9.3 2.8 1 8.8 0.0 2.4 3 0 0 3 3 3 0 Allexivirus 40kDa protein SAP18 PF06487.12 AMD22174.1 - 1.3 9.2 3.4 0.62 10.2 0.0 2.2 2 0 0 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) ATP-synt_C PF00137.21 AMD22175.1 - 7.4e-25 87.1 41.3 2.9e-16 59.5 12.9 2.5 3 0 0 3 3 3 2 ATP synthase subunit C DUF3671 PF12420.8 AMD22175.1 - 1.4 9.0 10.5 0.49 10.5 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function DUF5453 PF17534.2 AMD22175.1 - 4.2 7.3 7.7 0.82 9.6 0.2 2.4 2 1 1 3 3 3 0 Family of unknown function (DUF5453) GHMP_kinases_N PF00288.26 AMD22176.1 - 2.1e-10 40.7 0.0 4.2e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AMD22176.1 - 0.00062 20.1 0.0 0.0017 18.7 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal Peptidase_M16_C PF05193.21 AMD22177.1 - 5.7e-46 156.8 0.1 1.6e-45 155.3 0.0 1.9 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AMD22177.1 - 6.4e-35 120.3 0.7 2e-34 118.7 0.1 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF1947 PF09183.10 AMD22177.1 - 0.035 14.4 3.9 0.2 12.0 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1947) Myosin_head PF00063.21 AMD22178.1 - 4.7e-263 874.4 11.2 4.7e-263 874.4 11.2 2.9 3 0 0 3 3 3 1 Myosin head (motor domain) DUF4201 PF13870.6 AMD22178.1 - 5.6e-05 22.9 13.9 5.6e-05 22.9 13.9 9.4 3 2 4 8 8 8 2 Domain of unknown function (DUF4201) Myosin_N PF02736.19 AMD22178.1 - 0.0017 18.2 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain CENP-F_leu_zip PF10473.9 AMD22178.1 - 0.0057 16.7 20.2 0.0057 16.7 20.2 11.2 2 2 8 10 10 10 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_22 PF13401.6 AMD22178.1 - 0.11 12.7 0.0 0.11 12.7 0.0 4.6 4 3 0 4 4 4 0 AAA domain AAA_16 PF13191.6 AMD22178.1 - 0.23 11.8 0.0 0.23 11.8 0.0 4.0 3 2 0 3 3 3 0 AAA ATPase domain zf-CCCH_6 PF18585.1 AMD22178.1 - 0.27 11.1 1.3 3.3 7.7 0.2 3.7 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Pox_A_type_inc PF04508.12 AMD22178.1 - 0.6 10.1 17.4 19 5.3 0.2 7.4 7 0 0 7 7 7 0 Viral A-type inclusion protein repeat Ras PF00071.22 AMD22179.1 - 2.7e-24 85.6 0.1 9.6e-22 77.3 0.1 2.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 AMD22179.1 - 3e-09 37.1 0.0 0.00038 20.6 0.0 2.4 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AMD22179.1 - 0.00077 19.5 0.1 0.47 10.6 0.0 3.0 1 1 1 2 2 2 2 50S ribosome-binding GTPase KIAA1430 PF13879.6 AMD22179.1 - 0.036 14.8 0.1 0.81 10.5 0.0 2.4 2 0 0 2 2 2 0 KIAA1430 homologue Peptidase_S10 PF00450.22 AMD22180.1 - 1.9e-96 324.0 0.0 2.5e-96 323.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Aminotran_1_2 PF00155.21 AMD22181.1 - 1.7e-18 66.9 0.0 2.2e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 AMD22181.1 - 0.044 13.1 0.0 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Phosphorylase PF00343.20 AMD22182.1 - 0 1021.7 0.0 0 1021.4 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Mrr_cat_2 PF13156.6 AMD22182.1 - 0.012 15.5 0.4 0.051 13.5 0.0 2.3 3 0 0 3 3 3 0 Restriction endonuclease MCM PF00493.23 AMD22183.1 - 4.4e-104 346.5 0.4 6.4e-104 345.9 0.4 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AMD22183.1 - 2.8e-39 133.8 0.1 5.7e-39 132.8 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 AMD22183.1 - 2.3e-30 105.0 1.1 2.3e-30 105.0 1.1 2.6 4 0 0 4 4 4 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 AMD22183.1 - 9.2e-27 93.3 1.6 2.7e-26 91.8 1.6 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AMD22183.1 - 2e-20 73.3 1.9 3.3e-20 72.6 0.4 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 AMD22183.1 - 4e-07 29.6 0.0 1.5e-06 27.8 0.0 1.9 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AMD22183.1 - 0.0044 16.9 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AMD22183.1 - 0.0054 16.4 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 AMD22183.1 - 0.061 13.3 0.0 0.17 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SKN1 PF03935.15 AMD22184.1 - 1.9e-245 815.0 1.7 2.2e-245 814.7 1.7 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) SIS PF01380.22 AMD22185.1 - 1.4e-11 44.3 0.0 2.4e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 AMD22185.1 - 1.5e-05 25.0 0.0 0.014 15.5 0.0 2.3 1 1 0 1 1 1 1 SIS domain Macoilin PF09726.9 AMD22186.1 - 7.5 5.0 13.6 9.6 4.6 13.6 1.1 1 0 0 1 1 1 0 Macoilin family NpwBP PF12622.7 AMD22187.1 - 1.1 10.1 4.2 0.3 11.9 0.7 2.0 2 0 0 2 2 2 0 mRNA biogenesis factor Actin PF00022.19 AMD22188.1 - 1.2e-21 76.8 0.0 2.7e-11 42.7 0.0 2.4 1 1 1 2 2 2 2 Actin Shufflon_N PF04917.12 AMD22188.1 - 0.014 14.8 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Serinc PF03348.15 AMD22189.1 - 1.1e-129 433.2 18.0 1.3e-129 432.9 18.0 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) YlaC PF10777.9 AMD22189.1 - 5.7 6.8 10.6 14 5.5 1.2 2.8 1 1 1 2 2 2 0 Inner membrane protein YlaC NOD2_WH PF17779.1 AMD22190.1 - 0.18 12.1 0.0 0.22 11.9 0.0 1.2 1 0 0 1 1 1 0 NOD2 winged helix domain Peptidase_M24 PF00557.24 AMD22191.1 - 3.4e-06 26.9 0.1 1.8e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 Metallopeptidase family M24 E1_dh PF00676.20 AMD22192.1 - 1.3e-121 405.1 0.2 2e-121 404.6 0.2 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 AMD22192.1 - 0.0019 17.5 0.0 0.0032 16.7 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.6 AMD22192.1 - 0.15 13.0 6.9 0.3 12.1 0.1 3.4 2 2 1 3 3 3 0 KRTAP type 7 family Ste5_C PF12194.8 AMD22193.1 - 2e-70 236.6 4.0 3.8e-70 235.7 4.0 1.4 1 0 0 1 1 1 1 Protein kinase Fus3-binding PH_10 PF15411.6 AMD22193.1 - 0.027 14.8 0.0 0.065 13.5 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain SCAPER_N PF16501.5 AMD22193.1 - 0.096 12.7 0.1 5.6 7.0 0.0 2.6 2 0 0 2 2 2 0 S phase cyclin A-associated protein in the endoplasmic reticulum B12-binding PF02310.19 AMD22193.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain zf-RING_2 PF13639.6 AMD22193.1 - 0.51 10.7 10.3 0.039 14.3 4.9 1.9 2 0 0 2 2 2 0 Ring finger domain zf-RING_11 PF17123.5 AMD22193.1 - 3.4 7.5 7.6 7.9 6.3 7.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger PH_4 PF15404.6 AMD22194.1 - 2.3e-64 216.6 0.0 4.2e-64 215.7 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Spo7_2_N PF15407.6 AMD22194.1 - 4e-17 61.6 0.0 1e-16 60.3 0.0 1.8 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.29 AMD22194.1 - 0.0016 18.9 1.9 8.7 6.9 0.1 4.5 4 0 0 4 4 4 2 PH domain COPI_assoc PF08507.10 AMD22195.1 - 7.4e-30 103.7 8.4 8.5e-30 103.5 8.4 1.0 1 0 0 1 1 1 1 COPI associated protein Cyt_bd_oxida_I PF01654.17 AMD22195.1 - 0.032 12.9 0.6 0.032 12.9 0.6 1.9 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit I 14-3-3 PF00244.20 AMD22196.1 - 1.6e-106 354.8 4.3 1.8e-106 354.6 4.3 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 AMD22196.1 - 0.0044 17.0 0.2 0.011 15.8 0.2 1.6 1 0 0 1 1 1 1 Flagellar protein FlaF Paf1 PF03985.13 AMD22196.1 - 0.017 14.2 0.2 0.023 13.7 0.2 1.2 1 0 0 1 1 1 0 Paf1 Glutaredoxin PF00462.24 AMD22197.1 - 2.6e-19 69.2 0.0 2.8e-17 62.7 0.0 2.9 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin PF00085.20 AMD22197.1 - 3.6e-14 52.6 0.0 6.7e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AMD22197.1 - 4.4e-07 30.1 0.2 8e-05 22.9 0.0 2.5 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 AMD22197.1 - 0.00017 21.5 0.0 0.00036 20.4 0.0 1.5 2 0 0 2 2 2 1 AhpC/TSA family OST3_OST6 PF04756.13 AMD22197.1 - 0.0031 16.9 0.0 0.0033 16.8 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 AMD22197.1 - 0.012 16.0 0.0 0.1 13.1 0.0 2.3 2 1 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_7 PF13899.6 AMD22197.1 - 0.021 15.0 0.0 0.063 13.5 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin-like HyaE PF07449.11 AMD22197.1 - 0.05 13.6 0.0 1.8 8.6 0.0 2.4 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Rad17 PF03215.15 AMD22198.1 - 2.3e-39 135.3 0.0 6.6e-39 133.8 0.0 1.8 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 AMD22198.1 - 0.0016 18.9 0.0 0.0039 17.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 AMD22198.1 - 0.016 15.6 0.0 0.055 13.9 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD22198.1 - 0.016 15.5 0.0 0.054 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 AMD22198.1 - 0.018 14.2 0.0 0.034 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 AMD22198.1 - 0.02 14.9 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 AMD22198.1 - 0.03 14.0 0.0 0.071 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 AMD22198.1 - 0.12 12.8 0.0 0.49 10.8 0.0 2.0 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 AMD22198.1 - 0.19 12.2 0.4 0.64 10.5 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Sec63 PF02889.16 AMD22199.1 - 1.4e-141 470.1 6.3 2.4e-78 262.8 0.4 2.6 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 AMD22199.1 - 4.2e-43 147.2 0.5 5.8e-28 97.8 0.1 3.7 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 AMD22199.1 - 1.3e-22 80.6 5.2 1.8e-15 57.3 0.0 3.6 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_PWI PF18149.1 AMD22199.1 - 1.8e-11 44.2 1.0 1.8e-11 44.2 1.0 2.8 3 0 0 3 3 3 1 N-terminal helicase PWI domain Helicase_C PF00271.31 AMD22199.1 - 4.1e-11 43.2 0.2 1.8e-08 34.7 0.0 4.2 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AMD22199.1 - 2.9e-06 27.6 0.1 0.035 14.4 0.0 4.2 3 0 0 3 3 3 2 AAA domain SNF2_N PF00176.23 AMD22199.1 - 0.00034 19.4 0.0 0.00082 18.2 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_34 PF13872.6 AMD22199.1 - 0.011 14.7 0.0 0.23 10.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 DEAD_2 PF06733.15 AMD22200.1 - 1.7e-55 187.3 4.4 1.7e-55 187.3 4.4 2.2 2 0 0 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.6 AMD22200.1 - 7.5e-44 149.9 0.0 2.5e-43 148.2 0.0 2.0 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 AMD22200.1 - 1.1e-43 149.1 3.6 4.4e-40 137.4 1.3 2.8 2 0 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 AMD22200.1 - 0.00027 21.0 0.6 0.0098 15.9 0.1 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ADK PF00406.22 AMD22201.1 - 1.1e-38 132.7 0.0 1.3e-38 132.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AMD22201.1 - 5.4e-14 52.8 0.0 8.8e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 AMD22201.1 - 1.3e-13 50.6 0.0 2e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 AMD22201.1 - 0.0039 17.7 0.0 0.01 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AMD22201.1 - 0.072 13.2 0.0 0.74 10.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 AMD22201.1 - 0.091 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MutS_V PF00488.21 AMD22202.1 - 9.3e-65 218.2 0.0 1.7e-64 217.4 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AMD22202.1 - 6.3e-34 117.9 0.2 1.3e-33 116.8 0.2 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 AMD22202.1 - 8.2e-32 109.8 0.0 1.9e-31 108.6 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 AMD22202.1 - 1.1e-14 54.6 0.1 2.7e-14 53.3 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 AMD22202.1 - 9.1e-13 48.7 0.0 2.2e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.6 AMD22202.1 - 0.08 12.7 0.0 0.24 11.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 AMD22202.1 - 0.1 12.1 0.0 0.35 10.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AMD22202.1 - 0.59 10.6 0.0 0.59 10.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain JmjC PF02373.22 AMD22203.1 - 1.1e-40 138.6 2.2 3.2e-40 137.1 1.5 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.17 AMD22203.1 - 2.5e-11 43.3 2.1 2.5e-11 43.3 2.1 2.6 2 0 0 2 2 2 1 jmjN domain zf-H2C2_2 PF13465.6 AMD22203.1 - 1.6e-06 28.3 6.7 1.6e-06 28.3 6.7 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 AMD22203.1 - 1.3e-05 25.4 15.0 0.0083 16.5 2.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22203.1 - 0.00035 21.2 17.8 0.068 14.1 4.9 3.4 3 0 0 3 3 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 AMD22203.1 - 0.0012 18.9 3.9 0.003 17.6 3.9 1.7 1 0 0 1 1 1 1 Zinc ribbon domain zf-C2H2_6 PF13912.6 AMD22203.1 - 0.0043 17.0 14.5 0.0073 16.3 5.9 2.9 3 0 0 3 3 3 1 C2H2-type zinc finger DZR PF12773.7 AMD22203.1 - 0.075 13.1 0.7 0.18 11.8 0.7 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf_UBZ PF18439.1 AMD22203.1 - 0.1 12.2 3.8 4.8 6.9 0.3 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 AMD22203.1 - 0.17 11.9 0.2 0.34 11.0 0.2 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.6 AMD22203.1 - 0.39 10.8 1.8 21 5.2 0.1 2.5 1 1 1 2 2 2 0 CpXC protein zf_C2H2_ZHX PF18387.1 AMD22203.1 - 0.45 10.2 2.9 1.3 8.7 2.9 1.9 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-met PF12874.7 AMD22203.1 - 3.2 8.3 7.7 12 6.5 0.5 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD22203.1 - 4.6 7.7 15.6 0.19 12.0 4.6 3.0 2 1 1 3 3 2 0 Zinc-finger double-stranded RNA-binding PolyA_pol PF01743.20 AMD22204.1 - 7.2e-24 84.6 0.0 1.2e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 AMD22204.1 - 1.3e-05 24.8 0.0 3.2e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 AMD22204.1 - 0.0029 17.6 0.4 1.8 8.6 0.2 2.5 1 1 1 2 2 2 2 tRNA nucleotidyltransferase domain 2 putative Pox_I1 PF03289.13 AMD22204.1 - 0.012 14.8 1.6 0.057 12.5 0.1 2.6 2 1 1 3 3 3 0 Poxvirus protein I1 PhoLip_ATPase_C PF16212.5 AMD22206.1 - 6.4e-76 255.4 28.5 6.4e-76 255.4 28.5 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AMD22206.1 - 8e-19 67.1 0.6 2.1e-18 65.8 0.6 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 AMD22206.1 - 5.9e-12 45.5 0.0 2.8e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 AMD22206.1 - 1.1e-09 38.9 3.2 3.1e-05 24.4 1.2 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 AMD22206.1 - 1.8e-07 30.8 0.3 7.3e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AMD22206.1 - 0.001 18.9 0.0 0.0026 17.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UQ_con PF00179.26 AMD22207.1 - 2.6e-47 160.0 0.0 2.9e-47 159.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AMD22207.1 - 0.0043 16.8 0.0 0.0055 16.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 AMD22207.1 - 0.0084 16.0 0.1 0.014 15.2 0.1 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 AMD22207.1 - 0.013 15.8 0.1 0.017 15.4 0.1 1.3 1 0 0 1 1 1 0 RWD domain RRM_1 PF00076.22 AMD22208.1 - 1.4e-86 284.3 3.3 1.7e-20 72.6 0.1 4.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 AMD22208.1 - 1.1e-16 60.7 1.1 1.1e-16 60.7 1.1 3.0 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 AMD22208.1 - 6.7e-07 29.1 0.0 0.00087 19.1 0.0 3.3 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_3 PF08777.11 AMD22208.1 - 1.2e-06 28.4 10.6 0.28 11.3 0.1 5.1 5 1 0 5 5 5 3 RNA binding motif DUF4523 PF15023.6 AMD22208.1 - 0.00015 21.6 0.0 0.77 9.6 0.0 3.3 1 1 2 3 3 3 2 Protein of unknown function (DUF4523) Nup35_RRM_2 PF14605.6 AMD22208.1 - 0.0009 19.2 0.3 12 6.0 0.0 3.8 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 AMD22208.1 - 0.0016 18.5 0.5 6.1 7.0 0.0 4.8 4 3 0 4 4 4 1 RNA recognition motif OB_RNB PF08206.11 AMD22208.1 - 0.0073 16.0 1.6 17 5.2 0.1 3.5 3 0 0 3 3 3 2 Ribonuclease B OB domain PNPase PF03726.14 AMD22208.1 - 0.02 15.4 3.3 0.072 13.6 0.2 3.0 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain YflT PF11181.8 AMD22208.1 - 0.088 13.3 7.9 5.9 7.5 0.3 3.7 3 0 0 3 3 3 0 Heat induced stress protein YflT SNF2_N PF00176.23 AMD22209.1 - 5.1e-62 209.6 0.0 8.9e-62 208.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Cdh1_DBD_1 PF18196.1 AMD22209.1 - 2.3e-41 140.9 4.8 2.3e-41 140.9 4.8 2.9 3 0 0 3 3 3 1 Chromodomain helicase DNA-binding domain 1 DUF4208 PF13907.6 AMD22209.1 - 3e-25 88.5 1.2 3e-25 88.5 1.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Chromo PF00385.24 AMD22209.1 - 2.2e-23 81.9 3.7 5.8e-14 51.7 0.1 3.3 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 AMD22209.1 - 5.4e-20 71.8 0.0 1.4e-19 70.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD22209.1 - 2.2e-08 34.3 0.1 1.2e-07 31.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AMD22209.1 - 7.7e-07 28.6 0.4 4.6e-06 26.0 0.3 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.31 AMD22209.1 - 6.2e-06 26.3 0.1 4.3e-05 23.6 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain SLIDE PF09111.10 AMD22209.1 - 2.2e-05 24.5 0.4 0.00012 22.1 0.0 2.5 2 0 0 2 2 2 1 SLIDE Myb_DNA-bind_6 PF13921.6 AMD22209.1 - 0.00054 20.2 0.2 0.0036 17.5 0.0 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain CHDCT2 PF08074.11 AMD22209.1 - 0.23 11.6 0.0 0.23 11.6 0.0 3.3 4 2 1 5 5 5 0 CHDCT2 (NUC038) domain ABC_tran PF00005.27 AMD22210.1 - 8.1e-34 117.1 0.0 3.6e-16 59.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 AMD22210.1 - 1.7e-14 53.3 6.4 4e-14 52.1 6.4 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 AMD22210.1 - 2.4e-11 44.0 7.6 0.049 13.4 0.1 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AMD22210.1 - 2.9e-09 36.7 3.1 0.02 14.3 0.5 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 AMD22210.1 - 3.1e-08 33.1 2.9 3.1e-08 33.1 2.9 2.6 3 0 0 3 3 3 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 AMD22210.1 - 2.9e-06 27.3 0.0 0.038 13.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 AMD22210.1 - 1.2e-05 25.3 1.2 0.12 12.1 0.2 2.9 2 2 1 3 3 3 2 AAA ATPase domain AAA_16 PF13191.6 AMD22210.1 - 1.3e-05 25.6 0.0 0.015 15.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 AMD22210.1 - 1.4e-05 25.5 0.0 0.048 14.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AMD22210.1 - 5.5e-05 23.5 0.0 0.017 15.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4_6 PF12837.7 AMD22210.1 - 8.2e-05 22.5 13.8 0.00022 21.2 2.9 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.6 AMD22210.1 - 0.00015 21.5 0.5 0.54 10.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_21 PF14697.6 AMD22210.1 - 0.00056 20.0 12.4 0.0012 18.9 12.4 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 AMD22210.1 - 0.00088 19.8 0.4 0.00088 19.8 0.4 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 AMD22210.1 - 0.0012 18.9 0.7 0.0012 18.9 0.7 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_28 PF13521.6 AMD22210.1 - 0.0012 19.1 0.0 0.54 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 AMD22210.1 - 0.0013 18.6 0.1 0.45 10.4 0.1 2.9 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_24 PF13479.6 AMD22210.1 - 0.0016 18.2 0.2 0.51 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 AMD22210.1 - 0.0017 17.6 0.1 0.54 9.4 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 AMD22210.1 - 0.0017 18.5 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 AMD22210.1 - 0.0023 18.0 1.2 0.0023 18.0 1.2 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain RNA_helicase PF00910.22 AMD22210.1 - 0.0031 17.9 0.0 1 9.8 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 AMD22210.1 - 0.0037 17.0 0.2 0.31 10.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AMD22210.1 - 0.0046 16.9 1.1 0.48 10.3 0.0 2.5 2 0 0 2 2 2 1 NACHT domain SRP54 PF00448.22 AMD22210.1 - 0.005 16.5 2.3 0.31 10.6 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_18 PF13238.6 AMD22210.1 - 0.0075 16.8 0.0 6.8 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 AMD22210.1 - 0.0079 16.7 7.9 0.038 14.5 0.0 3.1 2 1 0 2 2 2 1 AAA domain Fer4_16 PF13484.6 AMD22210.1 - 0.0082 17.1 0.3 0.0082 17.1 0.3 2.8 2 1 1 3 3 1 1 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 AMD22210.1 - 0.012 15.8 11.8 0.025 14.7 11.8 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain VirE PF05272.11 AMD22210.1 - 0.015 15.0 0.0 5.5 6.7 0.0 2.5 2 0 0 2 2 2 0 Virulence-associated protein E AAA_7 PF12775.7 AMD22210.1 - 0.017 14.6 0.1 0.21 11.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 AMD22210.1 - 0.02 15.0 0.1 4 7.6 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_5 PF07728.14 AMD22210.1 - 0.022 14.8 0.5 0.26 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 AMD22210.1 - 0.024 14.6 0.0 0.36 10.8 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_17 PF13534.6 AMD22210.1 - 0.025 15.1 0.1 0.025 15.1 0.1 2.5 2 0 0 2 2 1 0 4Fe-4S dicluster domain AAA_14 PF13173.6 AMD22210.1 - 0.054 13.5 0.0 9.2 6.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 AMD22210.1 - 0.054 13.7 0.0 20 5.5 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TniB PF05621.11 AMD22210.1 - 0.07 12.5 0.1 1.9 7.8 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein Fer4_8 PF13183.6 AMD22210.1 - 0.11 12.9 0.2 0.11 12.9 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF815 PF05673.13 AMD22210.1 - 0.17 11.0 0.0 6 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DLIC PF05783.11 AMD22210.1 - 0.23 10.2 0.2 0.47 9.2 0.0 1.5 2 0 0 2 2 1 0 Dynein light intermediate chain (DLIC) AAA_13 PF13166.6 AMD22210.1 - 0.26 9.9 0.8 0.67 8.5 0.0 2.0 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 AMD22210.1 - 0.38 10.5 1.8 0.63 9.8 0.1 2.2 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation Fer4_4 PF12800.7 AMD22210.1 - 2.5 8.8 15.6 0.7 10.6 3.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Phosphodiest PF01663.22 AMD22211.1 - 1.5e-13 51.1 0.3 2.2e-13 50.6 0.3 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 AMD22211.1 - 0.0008 18.8 0.1 0.0012 18.2 0.1 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 AMD22211.1 - 0.078 12.3 0.1 0.17 11.3 0.1 1.6 1 0 0 1 1 1 0 Sulfatase Cellulase PF00150.18 AMD22211.1 - 0.083 12.3 0.1 0.18 11.2 0.1 1.5 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Aminotran_1_2 PF00155.21 AMD22212.1 - 1.1e-67 228.7 0.0 1.5e-67 228.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AMD22212.1 - 0.00055 19.0 0.0 0.00082 18.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 AMD22212.1 - 0.0089 14.8 0.0 0.013 14.2 0.0 1.1 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Acetyltransf_1 PF00583.25 AMD22213.1 - 1.2e-18 67.4 0.0 1.6e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AMD22213.1 - 4.1e-10 39.7 0.0 1.2e-09 38.2 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AMD22213.1 - 1.5e-06 28.3 0.0 0.00054 20.0 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AMD22213.1 - 4e-05 23.9 0.0 5.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AMD22213.1 - 0.047 13.8 0.1 0.067 13.3 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 AMD22213.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein FTR1 PF03239.14 AMD22214.1 - 9.4e-91 304.2 6.6 1.1e-90 303.9 6.6 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF3899 PF13038.6 AMD22214.1 - 1.9 9.0 10.3 4.2 7.9 0.2 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) LSM PF01423.22 AMD22215.1 - 1.2e-19 69.8 0.1 1.4e-19 69.5 0.1 1.1 1 0 0 1 1 1 1 LSM domain Glyco_transf_20 PF00982.21 AMD22217.1 - 2.8e-149 497.8 0.1 3.7e-149 497.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 AMD22217.1 - 8.1e-78 260.7 0.0 1.3e-77 260.1 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Cohesin_load PF10345.9 AMD22218.1 - 3.1e-80 270.3 19.8 4.2e-80 269.9 19.8 1.1 1 0 0 1 1 1 1 Cohesin loading factor IL10 PF00726.17 AMD22218.1 - 0.014 14.9 2.9 0.028 13.9 0.0 2.9 3 1 1 4 4 4 0 Interleukin 10 TBP PF00352.21 AMD22219.1 - 9.8e-68 224.1 0.2 1.7e-32 111.2 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 AMD22219.1 - 2e-05 24.6 0.1 0.21 11.8 0.0 2.7 2 1 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 AMD22219.1 - 0.036 13.9 0.2 0.26 11.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) CENP-O PF09496.10 AMD22220.1 - 2.9 7.8 7.8 1.5 8.7 4.2 2.3 2 1 0 2 2 2 0 Cenp-O kinetochore centromere component Fib_alpha PF08702.10 AMD22220.1 - 9.5 6.4 12.2 8.6 6.5 0.3 3.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Metallophos PF00149.28 AMD22221.1 - 3.3e-38 132.3 0.4 4.2e-38 131.9 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AMD22221.1 - 0.002 18.3 0.0 0.0028 17.9 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_65N PF03636.15 AMD22221.1 - 0.18 11.4 0.0 0.26 10.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Rad51 PF08423.11 AMD22222.1 - 2.8e-07 30.1 0.2 1.2e-05 24.7 0.2 2.1 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 AMD22222.1 - 5.1e-07 29.3 0.0 1.4e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 KaiC AAA_24 PF13479.6 AMD22222.1 - 0.00051 19.8 0.0 0.00099 18.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 AMD22222.1 - 0.00071 19.1 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase_2 PF01637.18 AMD22222.1 - 0.00095 19.1 0.8 0.004 17.1 0.0 2.1 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea DnaB_C PF03796.15 AMD22222.1 - 0.0036 16.7 0.1 0.018 14.4 0.0 2.1 2 1 0 3 3 3 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 AMD22222.1 - 0.0081 16.4 0.0 0.018 15.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 AMD22222.1 - 0.014 15.9 0.0 0.057 13.8 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 AMD22222.1 - 0.088 12.6 0.2 0.84 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain UCH PF00443.29 AMD22224.1 - 4.4e-51 173.8 1.6 1e-50 172.7 1.6 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD22224.1 - 8e-07 28.9 2.9 8e-07 28.9 2.9 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MgtE_N PF03448.17 AMD22224.1 - 0.055 14.1 0.3 0.11 13.1 0.3 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain SWIM PF04434.17 AMD22225.1 - 0.0047 16.6 1.0 0.092 12.4 0.1 2.3 2 0 0 2 2 2 1 SWIM zinc finger IKKbetaNEMObind PF12179.8 AMD22225.1 - 0.1 12.6 0.6 0.26 11.4 0.6 1.7 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain PET122 PF05476.11 AMD22226.1 - 1.3e-63 214.8 11.5 1.6e-63 214.5 11.5 1.0 1 0 0 1 1 1 1 PET122 60KD_IMP PF02096.20 AMD22227.1 - 2.5e-20 73.0 0.5 2.5e-20 73.0 0.5 1.5 2 0 0 2 2 2 1 60Kd inner membrane protein RhoGAP PF00620.27 AMD22228.1 - 2.1e-38 131.6 0.2 1.1e-37 129.2 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain RasGEF_N PF00618.20 AMD22228.1 - 8.9e-17 61.2 2.0 5.8e-16 58.6 0.4 3.0 1 1 1 2 2 2 1 RasGEF N-terminal motif RasGEF PF00617.19 AMD22228.1 - 3.4e-12 46.9 3.8 3.7e-11 43.5 0.1 3.3 3 0 0 3 3 3 1 RasGEF domain PH PF00169.29 AMD22228.1 - 4.7e-06 27.1 0.1 2.1e-05 25.0 0.1 2.2 1 0 0 1 1 1 1 PH domain UPF0160 PF03690.13 AMD22229.1 - 4.1e-130 434.1 0.0 4.6e-130 433.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Pet100 PF09803.9 AMD22230.1 - 9.7e-10 38.8 0.2 1.5e-09 38.2 0.2 1.3 1 0 0 1 1 1 1 Pet100 Sec34 PF04136.15 AMD22231.1 - 1.2e-39 135.6 8.7 1.2e-39 135.6 8.7 2.8 2 1 1 3 3 3 1 Sec34-like family HycH PF07450.11 AMD22231.1 - 0.091 13.1 1.4 1.7 9.0 0.3 2.8 2 0 0 2 2 2 0 Formate hydrogenlyase maturation protein HycH Col_cuticle_N PF01484.17 AMD22231.1 - 2 8.5 4.8 16 5.6 0.0 4.2 4 1 1 5 5 5 0 Nematode cuticle collagen N-terminal domain Occludin_ELL PF07303.13 AMD22231.1 - 5.4 7.8 13.7 2 9.2 2.4 4.6 3 1 2 5 5 5 0 Occludin homology domain RIH_assoc PF08454.11 AMD22231.1 - 6.6 6.6 9.7 0.13 12.1 0.2 3.1 3 0 0 3 3 3 0 RyR and IP3R Homology associated Tfb5 PF06331.12 AMD22232.1 - 8e-24 83.4 0.0 9e-24 83.2 0.0 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Clathrin PF00637.20 AMD22233.1 - 5.1e-28 97.7 1.0 5.1e-28 97.7 1.0 2.9 4 0 0 4 4 4 1 Region in Clathrin and VPS Vps39_1 PF10366.9 AMD22233.1 - 3.8e-05 23.9 1.4 8.3e-05 22.8 0.2 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 WD40 PF00400.32 AMD22233.1 - 0.0046 17.8 0.1 0.019 15.8 0.1 2.1 1 0 0 1 1 1 1 WD domain, G-beta repeat CENP-B_dimeris PF09026.10 AMD22233.1 - 3.5 8.1 14.0 0.36 11.3 7.2 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DDE_1 PF03184.19 AMD22234.1 - 4.3e-62 208.9 0.3 8.6e-62 207.9 0.3 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 AMD22234.1 - 2.5e-12 46.6 0.1 7.8e-12 45.0 0.1 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_ABP1_N PF18107.1 AMD22234.1 - 0.0001 22.0 0.0 0.00032 20.4 0.0 1.9 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain HTH_32 PF13565.6 AMD22234.1 - 0.15 12.7 0.1 1.1 10.0 0.1 2.3 2 0 0 2 2 2 0 Homeodomain-like domain Stn1 PF10451.9 AMD22235.1 - 3.5e-36 124.5 0.8 5.6e-36 123.8 0.8 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.7 AMD22235.1 - 3.3e-23 81.9 1.3 3.3e-23 81.9 1.3 3.3 4 0 0 4 4 4 1 Telomere capping C-terminal wHTH tRNA_anti-codon PF01336.25 AMD22235.1 - 0.049 13.6 0.4 0.16 11.9 0.2 2.0 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain Methyltransf_8 PF05148.15 AMD22236.1 - 5.3e-67 225.9 1.6 3.7e-65 219.9 0.2 2.6 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 AMD22236.1 - 1.6e-07 31.9 0.0 5.8e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD22236.1 - 0.00011 22.9 0.0 0.0013 19.4 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AMD22236.1 - 0.0033 17.2 0.1 0.18 11.6 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AMD22236.1 - 0.05 13.2 0.0 12 5.4 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_32 PF13679.6 AMD22236.1 - 1.7 8.6 0.0 1.7 8.6 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain Ndc1_Nup PF09531.10 AMD22236.1 - 7.5 5.1 8.4 10 4.6 8.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 AMD22236.1 - 9.2 4.9 7.6 14 4.3 7.6 1.2 1 0 0 1 1 1 0 Presenilin DUF846 PF05832.12 AMD22237.1 - 8.3e-44 149.0 4.4 9.8e-44 148.8 4.4 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Mannosyl_trans3 PF11051.8 AMD22238.1 - 3.6e-67 226.6 1.1 4.8e-67 226.2 0.8 1.3 1 1 0 1 1 1 1 Mannosyltransferase putative OCC1 PF15506.6 AMD22239.1 - 0.2 11.8 2.2 1 9.6 2.2 2.2 1 0 0 1 1 1 0 OCC1 family SSF PF00474.17 AMD22240.1 - 7.8e-06 25.0 35.6 0.00011 21.2 35.6 2.3 1 1 0 1 1 1 1 Sodium:solute symporter family CBFD_NFYB_HMF PF00808.23 AMD22241.1 - 4.6e-12 46.0 0.2 7.8e-12 45.3 0.2 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SecE PF00584.20 AMD22242.1 - 6.5e-12 45.2 0.0 7.2e-12 45.1 0.0 1.0 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Coiled-coil_56 PF09813.9 AMD22242.1 - 0.19 11.8 0.0 0.25 11.4 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Nop52 PF05997.12 AMD22243.1 - 1.6e-69 234.0 4.9 1.9e-69 233.8 4.9 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.8 AMD22243.1 - 0.03 14.5 1.2 0.093 12.9 0.0 2.2 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair Slu7 PF11708.8 AMD22244.1 - 5e-14 52.7 9.5 3.3e-11 43.5 9.5 2.3 1 1 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor OCRE PF17780.1 AMD22244.1 - 0.095 12.7 0.2 8 6.6 0.1 2.3 2 0 0 2 2 2 0 OCRE domain C1_1 PF00130.22 AMD22244.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CCHC PF00098.23 AMD22244.1 - 0.46 10.7 3.2 1 9.5 3.2 1.6 1 0 0 1 1 1 0 Zinc knuckle SPX PF03105.19 AMD22245.1 - 1.2e-06 28.7 1.1 5.8e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 SPX domain DUF1375 PF07119.12 AMD22245.1 - 0.055 13.9 0.0 0.19 12.2 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1375) SPT2 PF08243.11 AMD22246.1 - 7.7e-27 94.0 24.2 7.7e-27 94.0 24.2 2.6 3 1 1 4 4 4 1 SPT2 chromatin protein Rad4 PF03835.15 AMD22247.1 - 1.2e-35 122.3 1.2 2.8e-35 121.2 1.2 1.6 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 AMD22247.1 - 1.5e-24 86.1 0.6 5.3e-24 84.4 0.2 2.2 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 AMD22247.1 - 6.9e-15 54.6 0.0 1.7e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 AMD22247.1 - 7.6e-05 23.6 3.6 0.00022 22.1 0.9 3.3 2 1 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 AMD22247.1 - 0.00013 22.4 0.0 0.00045 20.7 0.0 1.9 2 0 0 2 2 2 1 Transglutaminase-like superfamily CK_II_beta PF01214.18 AMD22248.1 - 1.7e-66 223.5 0.0 2.1e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HSCB_C PF07743.13 AMD22249.1 - 1.4e-13 51.1 6.2 2.4e-13 50.4 6.2 1.4 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 AMD22249.1 - 0.00024 21.1 0.3 0.0012 19.0 0.0 2.0 2 0 0 2 2 2 1 DnaJ domain CRISPR_Cse1 PF09481.10 AMD22249.1 - 0.044 12.9 0.2 0.057 12.5 0.2 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) Kri1 PF05178.12 AMD22249.1 - 0.093 13.3 2.7 0.17 12.5 1.6 1.9 2 0 0 2 2 2 0 KRI1-like family ATE_C PF04377.15 AMD22250.1 - 6.9e-45 153.0 0.4 1.4e-44 152.0 0.4 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 AMD22250.1 - 4.2e-26 91.2 5.1 7.6e-26 90.3 5.1 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus SOR PF07682.11 AMD22251.1 - 0.043 12.7 0.0 0.078 11.9 0.0 1.4 1 0 0 1 1 1 0 Sulphur oxygenase reductase Urb2 PF10441.9 AMD22251.1 - 0.5 10.3 4.2 0.58 10.0 0.4 3.0 3 0 0 3 3 3 0 Urb2/Npa2 family DUF842 PF05811.13 AMD22251.1 - 0.92 9.2 2.9 11 5.7 0.4 2.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Aminotran_1_2 PF00155.21 AMD22252.1 - 2.6e-14 53.2 0.0 3.9e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II WD40 PF00400.32 AMD22253.1 - 4.4e-28 96.9 16.0 6.6e-08 33.1 0.0 8.0 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22253.1 - 8e-15 54.9 0.1 0.0032 17.7 0.0 6.9 5 1 3 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 AMD22253.1 - 4.3e-11 43.0 0.0 1.5e-10 41.2 0.0 1.9 2 0 0 2 2 2 1 TUP1-like enhancer of split HIRA_B PF09453.10 AMD22253.1 - 2e-05 24.3 0.2 4.8e-05 23.1 0.2 1.7 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 AMD22253.1 - 0.00097 19.0 0.1 3.9 7.5 0.0 3.9 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 AMD22253.1 - 0.0038 16.2 0.1 0.29 10.0 0.0 3.6 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AMD22253.1 - 0.0064 15.9 0.7 3.5 6.9 0.0 3.0 4 0 0 4 4 4 2 WD40-like domain IKI3 PF04762.12 AMD22253.1 - 0.04 11.9 0.3 2.8 5.8 0.0 3.3 3 1 1 4 4 4 0 IKI3 family Aconitase PF00330.20 AMD22254.1 - 3.5e-160 534.0 0.0 4.3e-160 533.7 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AMD22254.1 - 7.9e-42 142.7 0.0 1.7e-41 141.6 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain SH3_1 PF00018.28 AMD22255.1 - 8.4e-37 124.6 7.3 3.4e-14 52.2 0.0 4.6 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.6 AMD22255.1 - 1.2e-32 111.5 8.4 4.6e-11 42.4 0.4 4.6 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 AMD22255.1 - 7e-31 105.7 0.3 2.6e-11 43.0 0.1 4.5 4 0 0 4 4 4 4 Variant SH3 domain SHD1 PF03983.12 AMD22255.1 - 1.7e-28 98.2 0.2 3.2e-28 97.3 0.2 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 hSH3 PF14603.6 AMD22255.1 - 0.00082 19.8 0.0 0.096 13.1 0.0 3.5 3 0 0 3 3 3 1 Helically-extended SH3 domain DUF962 PF06127.11 AMD22256.1 - 6.7e-25 87.0 2.6 2.1e-24 85.4 2.6 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF4233 PF14017.6 AMD22256.1 - 0.85 10.0 6.3 0.93 9.9 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4233) Proteasome PF00227.26 AMD22257.1 - 1.5e-45 155.1 0.0 2.2e-45 154.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AMD22257.1 - 1.6e-15 56.4 0.1 3.7e-15 55.3 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Rsc14 PF08586.10 AMD22258.1 - 1.3e-36 125.4 0.3 1.8e-36 124.9 0.3 1.2 1 0 0 1 1 1 1 RSC complex, Rsc14/Ldb7 subunit ERG4_ERG24 PF01222.17 AMD22259.1 - 3.3e-162 540.1 24.5 3.8e-162 539.9 24.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family PUF PF00806.19 AMD22260.1 - 8.9e-61 198.3 12.4 1.2e-08 34.1 0.7 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Sacchrp_dh_NADP PF03435.18 AMD22260.1 - 0.00092 19.5 0.1 0.024 14.9 0.1 2.5 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Toxin_17 PF08086.11 AMD22260.1 - 0.77 10.1 5.1 1.8 8.9 5.1 1.6 1 0 0 1 1 1 0 Ergtoxin family E1-E2_ATPase PF00122.20 AMD22261.1 - 1.1e-48 165.2 5.7 4.9e-48 163.0 5.2 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AMD22261.1 - 2.1e-19 70.7 0.1 4.9e-19 69.4 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 AMD22261.1 - 2.5e-11 43.1 0.0 6.2e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 AMD22261.1 - 0.0088 16.1 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 AMD22261.1 - 0.011 15.5 0.1 0.024 14.4 0.1 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Zn_clus PF00172.18 AMD22262.1 - 1.5e-06 28.2 10.2 3.5e-06 27.0 10.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4175 PF13779.6 AMD22262.1 - 0.024 12.6 16.5 0.034 12.1 16.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF1247 PF06851.11 AMD22262.1 - 0.085 12.8 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) eIF-3_zeta PF05091.12 AMD22262.1 - 0.088 11.8 6.2 0.22 10.4 6.2 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MecA PF05389.12 AMD22262.1 - 0.1 12.2 1.5 1.1 8.8 0.2 2.2 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF4770 PF15994.5 AMD22262.1 - 0.12 12.6 7.9 0.31 11.3 7.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) UDPGP PF01704.18 AMD22263.1 - 2e-185 616.3 0.0 3.8e-185 615.4 0.0 1.4 2 0 0 2 2 2 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 AMD22263.1 - 0.063 12.1 0.0 0.57 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4301) zf-rbx1 PF12678.7 AMD22264.1 - 8.7e-10 38.7 5.3 1.5e-09 37.9 5.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AMD22264.1 - 1.1e-08 35.2 7.1 3e-08 33.9 7.1 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AMD22264.1 - 4.9e-07 29.5 2.7 4.9e-07 29.5 2.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD22264.1 - 6.3e-07 29.2 3.8 1.1e-06 28.5 3.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 AMD22264.1 - 2.5e-06 27.3 6.6 4.7e-06 26.4 6.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AMD22264.1 - 2.5e-05 23.9 6.1 0.0022 17.7 0.8 2.7 2 0 0 2 2 2 2 RING-like zinc finger Prok-RING_4 PF14447.6 AMD22264.1 - 4.1e-05 23.4 3.0 7.3e-05 22.5 1.4 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 AMD22264.1 - 6.9e-05 22.8 3.0 0.00017 21.5 3.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AMD22264.1 - 0.00075 19.3 5.6 0.0027 17.5 5.6 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 AMD22264.1 - 0.0012 18.4 1.3 0.0033 17.0 1.3 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 AMD22264.1 - 0.0018 18.3 1.0 0.0043 17.1 1.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Tap-RNA_bind PF09162.10 AMD22264.1 - 0.059 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Tap, RNA-binding FANCL_C PF11793.8 AMD22264.1 - 0.13 12.4 6.2 0.51 10.6 6.2 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 AMD22264.1 - 1.1 9.5 5.7 3.5 7.8 5.7 1.9 1 1 0 1 1 1 0 RING-variant domain HAD_2 PF13419.6 AMD22265.1 - 8.5e-19 68.3 0.0 1e-18 68.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AMD22265.1 - 8.3e-13 49.1 0.0 9.8e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 AMD22265.1 - 0.00012 22.2 0.0 0.00033 20.7 0.0 1.8 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Pribosyl_synth PF14572.6 AMD22266.1 - 7.2e-42 143.5 3.6 2.3e-35 122.3 2.9 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AMD22266.1 - 7.8e-40 135.4 0.2 4.5e-39 133.0 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AMD22266.1 - 3.5e-17 62.4 0.7 7.7e-17 61.3 0.6 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AMD22266.1 - 0.0043 16.5 0.2 0.0084 15.6 0.2 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase BRAP2 PF07576.12 AMD22267.1 - 1.5e-28 98.9 0.1 3.3e-28 97.8 0.1 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 AMD22267.1 - 1.2e-21 76.8 9.8 4.3e-21 75.0 9.8 2.0 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 AMD22267.1 - 3.1e-08 33.8 9.1 3.1e-08 33.8 9.1 2.6 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AMD22267.1 - 4.3e-06 26.5 9.4 4.3e-06 26.5 9.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD22267.1 - 1.2e-05 25.3 2.3 1.2e-05 25.3 2.3 2.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 AMD22267.1 - 3.1e-05 23.8 8.4 3.1e-05 23.8 8.4 2.6 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 AMD22267.1 - 8.7e-05 22.2 4.5 8.7e-05 22.2 4.5 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 AMD22267.1 - 0.00011 22.4 7.1 0.00011 22.4 7.1 2.3 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AMD22267.1 - 0.00031 20.5 8.8 0.00031 20.5 8.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD22267.1 - 0.00059 19.6 20.6 0.0012 18.6 6.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF4482 PF14818.6 AMD22267.1 - 0.0017 19.3 12.6 0.0073 17.2 12.6 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4482) zf-RING_4 PF14570.6 AMD22267.1 - 0.0049 16.6 6.6 0.015 15.1 6.6 1.9 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 AMD22267.1 - 0.01 15.9 5.0 0.01 15.9 5.0 2.1 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UBP_var PF17807.1 AMD22267.1 - 0.029 14.1 2.5 0.081 12.7 2.5 1.8 1 0 0 1 1 1 0 Variant UBP zinc finger CorA PF01544.18 AMD22267.1 - 0.04 13.2 10.4 0.063 12.6 10.4 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein HeLo PF14479.6 AMD22267.1 - 0.088 12.6 4.8 0.15 11.9 4.8 1.3 1 0 0 1 1 1 0 Prion-inhibition and propagation SnoaL_2 PF12680.7 AMD22267.1 - 0.16 12.6 0.0 0.47 11.1 0.0 1.7 2 0 0 2 2 1 0 SnoaL-like domain DUF1664 PF07889.12 AMD22267.1 - 0.27 11.3 10.0 0.1 12.7 7.2 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 AMD22267.1 - 0.37 11.3 6.0 0.79 10.2 0.4 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Myb_DNA-bind_4 PF13837.6 AMD22267.1 - 0.43 11.0 3.7 1 9.8 3.7 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Baculo_PEP_C PF04513.12 AMD22267.1 - 0.48 10.5 8.5 1.8 8.6 8.5 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prok-RING_4 PF14447.6 AMD22267.1 - 0.63 9.9 21.9 3.5 7.6 10.5 3.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 AAA_11 PF13086.6 AMD22267.1 - 0.76 9.5 8.4 1.3 8.8 8.4 1.3 1 0 0 1 1 1 0 AAA domain LMBR1 PF04791.16 AMD22267.1 - 0.79 8.6 6.2 1 8.2 6.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Phasin PF05597.11 AMD22267.1 - 1 9.4 7.2 0.36 10.8 4.4 1.6 2 0 0 2 2 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) FapA PF03961.13 AMD22267.1 - 1.3 7.6 9.9 2 6.9 9.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 AMD22267.1 - 2.4 7.4 7.6 3.5 6.9 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GIT_CC PF16559.5 AMD22267.1 - 3.2 7.7 10.0 1 9.3 0.5 3.2 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Uso1_p115_C PF04871.13 AMD22267.1 - 5.6 7.4 17.6 23 5.4 17.3 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Laminin_II PF06009.12 AMD22267.1 - 7.7 6.5 10.6 4.3 7.4 6.2 2.1 1 1 1 2 2 2 0 Laminin Domain II Baculo_PEP_C PF04513.12 AMD22268.1 - 5.4 7.1 7.2 1.2 9.2 1.1 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Form_Nir_trans PF01226.17 AMD22269.1 - 2.2e-59 200.7 26.2 2.9e-59 200.3 26.2 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter MNHE PF01899.16 AMD22269.1 - 0.25 11.1 0.1 0.25 11.1 0.1 3.0 2 1 1 3 3 3 0 Na+/H+ ion antiporter subunit Cnd1 PF12717.7 AMD22270.1 - 0.0056 16.7 0.2 0.0056 16.7 0.2 5.0 6 1 1 7 7 7 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AMD22270.1 - 0.2 12.1 0.0 23 5.5 0.0 3.3 3 0 0 3 3 3 0 HEAT repeats Syntaxin_2 PF14523.6 AMD22270.1 - 7.7 7.0 10.2 0.4 11.1 0.9 3.5 3 0 0 3 3 3 0 Syntaxin-like protein PHD PF00628.29 AMD22271.1 - 7.3e-16 57.8 21.7 5e-10 39.1 8.5 3.0 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.6 AMD22271.1 - 0.0024 17.4 10.4 0.2 11.3 0.3 3.4 3 0 0 3 3 3 2 PHD-finger PHD_4 PF16866.5 AMD22271.1 - 0.013 15.6 4.6 0.013 15.6 4.6 3.0 3 0 0 3 3 3 0 PHD-finger YfmQ PF10787.9 AMD22271.1 - 0.059 13.1 0.1 0.17 11.7 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group TPR_MLP1_2 PF07926.12 AMD22271.1 - 1.8 8.7 5.5 0.28 11.3 0.7 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein zf-PHD-like PF15446.6 AMD22271.1 - 2.5 7.7 10.1 4.3 6.9 0.7 2.9 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain dsDNA_bind PF01984.20 AMD22272.1 - 3.6e-23 82.0 4.6 1.6e-22 79.9 4.6 1.7 1 1 0 1 1 1 1 Double-stranded DNA-binding domain Sigma70_r2 PF04542.14 AMD22272.1 - 0.098 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-70 region 2 Cyt-b5 PF00173.28 AMD22273.1 - 2.6e-14 53.1 0.0 4e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HMG_box PF00505.19 AMD22274.1 - 8.7e-32 109.4 14.0 3.4e-18 65.8 6.1 2.8 3 0 0 3 3 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 AMD22274.1 - 3.1e-18 66.1 10.0 4e-11 43.3 4.9 3.4 3 0 0 3 3 2 2 HMG-box domain CHDNT PF08073.12 AMD22274.1 - 7.1e-08 32.3 0.0 0.012 15.6 0.0 2.6 2 0 0 2 2 2 2 CHDNT (NUC034) domain Presenilin PF01080.17 AMD22274.1 - 0.16 10.7 11.8 0.21 10.3 11.8 1.3 1 0 0 1 1 1 0 Presenilin TERB2 PF15101.6 AMD22274.1 - 0.24 11.5 12.3 0.54 10.3 12.3 1.7 1 0 0 1 1 1 0 Telomere-associated protein TERB2 NOA36 PF06524.12 AMD22274.1 - 0.37 10.1 6.5 0.67 9.2 6.5 1.3 1 0 0 1 1 1 0 NOA36 protein Pkinase_fungal PF17667.1 AMD22274.1 - 0.41 9.4 3.8 0.64 8.7 3.8 1.2 1 0 0 1 1 1 0 Fungal protein kinase Connexin PF00029.19 AMD22274.1 - 0.46 10.2 3.7 0.93 9.2 3.7 1.5 1 0 0 1 1 1 0 Connexin EOS1 PF12326.8 AMD22274.1 - 1.1 9.2 3.4 2.3 8.1 3.4 1.6 1 0 0 1 1 1 0 N-glycosylation protein Serinc PF03348.15 AMD22274.1 - 3.7 6.4 5.6 5.2 5.9 5.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) EIIBC-GUT_N PF03612.14 AMD22274.1 - 5.2 6.8 8.4 15 5.3 8.4 1.8 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CobT PF06213.12 AMD22274.1 - 6.3 6.1 17.5 11 5.3 17.5 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT zinc_ribbon_6 PF14599.6 AMD22275.1 - 1.6e-21 76.0 2.7 1.6e-21 76.0 2.7 3.7 4 1 0 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 AMD22275.1 - 3e-16 59.7 20.5 3e-16 59.7 20.5 3.8 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 AMD22275.1 - 6.4e-07 29.6 9.8 6.4e-07 29.6 9.8 5.5 4 2 2 6 6 6 2 Ring finger domain zf-C3HC4_2 PF13923.6 AMD22275.1 - 0.00026 20.8 9.5 0.00026 20.8 9.5 5.7 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD22275.1 - 0.00038 20.4 11.1 0.00038 20.4 11.1 6.3 3 3 2 5 5 5 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AMD22275.1 - 0.00053 20.0 8.4 0.00053 20.0 8.4 4.4 4 1 0 4 4 4 1 RING-type zinc-finger Prok-RING_4 PF14447.6 AMD22275.1 - 0.0045 16.8 4.8 0.0045 16.8 4.8 5.0 4 2 1 5 5 5 2 Prokaryotic RING finger family 4 Cg6151-P PF10233.9 AMD22276.1 - 6e-36 123.2 11.2 7.3e-36 122.9 11.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF5325 PF17259.2 AMD22276.1 - 0.099 12.5 0.4 0.099 12.5 0.4 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5325) DUF3270 PF11674.8 AMD22276.1 - 0.14 12.4 10.9 1.4 9.1 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) PRA1 PF03208.19 AMD22276.1 - 0.68 9.6 7.4 0.89 9.2 7.4 1.2 1 0 0 1 1 1 0 PRA1 family protein IncE PF17627.2 AMD22276.1 - 1.6 8.7 6.9 0.83 9.7 1.4 2.1 2 0 0 2 2 2 0 Inclusion membrane protein E zf-C2H2 PF00096.26 AMD22277.1 - 0.0004 20.7 6.1 0.0004 20.7 6.1 3.5 3 1 1 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22277.1 - 0.04 14.7 6.4 0.04 14.7 6.4 4.1 3 1 1 4 4 4 0 C2H2-type zinc finger PyrI_C PF02748.15 AMD22277.1 - 0.34 10.8 1.2 1.3 9.0 0.2 2.1 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Acetyltransf_1 PF00583.25 AMD22278.1 - 4.6e-06 26.9 0.0 6.4e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AMD22278.1 - 0.00024 21.5 0.0 0.00054 20.3 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain NIF PF03031.18 AMD22279.1 - 1.3e-49 167.9 0.0 1.8e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MFS_1 PF07690.16 AMD22280.1 - 2.3e-35 122.2 22.8 3.6e-35 121.5 22.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AMD22280.1 - 1.1e-15 57.5 23.6 1.8e-14 53.5 6.4 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 AMD22280.1 - 0.0014 17.2 5.0 0.0023 16.4 5.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) HKR_ArcB_TM PF18415.1 AMD22280.1 - 0.3 11.9 3.8 15 6.5 0.4 3.1 2 0 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain Malic_M PF03949.15 AMD22281.1 - 1.9e-84 282.9 0.0 2.7e-84 282.5 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 AMD22281.1 - 3.6e-61 206.1 0.0 6e-61 205.4 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain TFIIE_alpha PF02002.17 AMD22282.1 - 4.7e-29 100.3 0.6 1.4e-28 98.8 0.1 2.1 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 AMD22282.1 - 3.8e-08 32.7 1.5 1.2e-07 31.1 1.5 1.9 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_37 PF13744.6 AMD22282.1 - 0.06 13.3 1.6 0.99 9.4 0.0 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain zf-CHY PF05495.12 AMD22282.1 - 0.18 12.3 0.7 0.36 11.3 0.7 1.4 1 0 0 1 1 1 0 CHY zinc finger ThiF PF00899.21 AMD22283.1 - 2.5e-42 144.9 0.0 3.9e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.18 AMD22283.1 - 0.0038 17.5 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 AMD22283.1 - 0.0087 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 AMD22283.1 - 0.019 15.2 2.3 0.15 12.4 0.7 2.7 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Mito_carr PF00153.27 AMD22284.1 - 6.8e-59 195.8 1.8 1e-20 73.4 0.1 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF2370 PF10176.9 AMD22285.1 - 1.4e-78 263.6 0.0 1.8e-78 263.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Mito_carr PF00153.27 AMD22286.1 - 4.8e-62 205.9 3.2 6.6e-25 86.9 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein SNF5 PF04855.12 AMD22287.1 - 8.4e-49 166.5 1.7 8.4e-49 166.5 1.7 4.4 3 1 0 3 3 3 1 SNF5 / SMARCB1 / INI1 Adap_comp_sub PF00928.21 AMD22288.1 - 3.6e-45 154.4 0.0 4.6e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AMD22288.1 - 7.8e-05 22.6 0.1 0.00013 21.9 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain adh_short PF00106.25 AMD22289.1 - 7.5e-85 283.3 12.5 2.3e-43 148.0 2.2 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AMD22289.1 - 6.6e-67 225.5 6.5 2.6e-34 118.8 0.3 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AMD22289.1 - 4.7e-29 101.6 6.2 1.8e-15 57.4 0.5 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.19 AMD22289.1 - 2.3e-26 91.8 0.0 5.1e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 AMD22289.1 - 9.9e-05 22.5 0.0 0.0017 18.5 0.0 2.4 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase DUF1776 PF08643.10 AMD22289.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) PglL_A PF15864.5 AMD22289.1 - 0.61 9.9 6.5 5.4 6.8 1.0 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase 3HCDH_N PF02737.18 AMD22289.1 - 2.3 8.1 4.5 8.7 6.2 0.1 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain QCR10 PF09796.9 AMD22290.1 - 5e-25 87.3 0.1 5.9e-25 87.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.10 AMD22290.1 - 0.035 14.0 0.1 0.052 13.5 0.1 1.4 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein BLOC1_2 PF10046.9 AMD22291.1 - 0.027 14.8 0.5 0.027 14.8 0.5 4.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ZapB PF06005.12 AMD22291.1 - 0.51 10.8 39.7 0.38 11.2 6.9 5.2 5 0 0 5 5 5 0 Cell division protein ZapB ERM PF00769.19 AMD22291.1 - 1.4 8.7 48.1 0.055 13.3 14.2 3.6 2 1 0 3 3 3 0 Ezrin/radixin/moesin family Spc7 PF08317.11 AMD22291.1 - 1.7 7.5 44.9 1.2 7.9 4.1 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein Syntaxin_2 PF14523.6 AMD22291.1 - 3 8.3 32.8 4.5 7.7 4.4 5.6 2 2 3 5 5 5 0 Syntaxin-like protein Spc42p PF11544.8 AMD22291.1 - 4.7 7.3 18.0 6.5 6.8 5.7 3.7 2 1 0 2 2 2 0 Spindle pole body component Spc42p COG2 PF06148.11 AMD22291.1 - 7.6 6.6 25.4 4.1 7.5 6.8 3.9 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 RXT2_N PF08595.11 AMD22292.1 - 0.0039 17.2 5.8 0.009 16.1 5.8 1.6 1 0 0 1 1 1 1 RXT2-like, N-terminal SDA1 PF05285.12 AMD22292.1 - 0.014 14.9 10.3 0.019 14.4 10.3 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 AMD22292.1 - 0.08 11.2 9.8 0.098 10.9 9.8 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 AMD22292.1 - 0.11 12.2 7.2 0.2 11.3 7.2 1.5 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 AMD22292.1 - 0.21 10.9 21.7 0.55 9.5 21.7 1.6 1 0 0 1 1 1 0 NOA36 protein DUF2722 PF10846.8 AMD22292.1 - 0.24 10.3 5.8 0.37 9.7 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) BUD22 PF09073.10 AMD22292.1 - 0.3 10.4 9.5 0.44 9.9 9.5 1.2 1 0 0 1 1 1 0 BUD22 Nucleo_P87 PF07267.11 AMD22292.1 - 0.8 8.5 10.1 1.2 7.9 10.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RNA_pol_3_Rpc31 PF11705.8 AMD22292.1 - 1.1 9.5 17.5 2.1 8.5 17.5 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PPP4R2 PF09184.11 AMD22292.1 - 1.9 8.0 14.5 3.5 7.1 14.5 1.4 1 0 0 1 1 1 0 PPP4R2 Astro_capsid_p PF12226.8 AMD22292.1 - 1.9 7.5 11.3 2.9 7.0 11.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2457 PF10446.9 AMD22292.1 - 2.5 7.2 19.3 4.1 6.4 19.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 AMD22292.1 - 2.9 6.1 9.9 3.9 5.6 9.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PRK PF00485.18 AMD22293.1 - 0.00024 20.9 0.0 0.32 10.7 0.0 2.3 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 AMD22293.1 - 0.00065 19.0 0.0 0.002 17.4 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 AMD22293.1 - 0.00067 19.8 0.0 0.1 12.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AMD22293.1 - 0.0012 19.4 0.0 0.0035 17.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AMD22293.1 - 0.0048 16.2 0.0 0.0081 15.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.10 AMD22293.1 - 0.0075 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 AMD22293.1 - 0.011 16.1 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 AMD22293.1 - 0.015 15.3 0.0 0.032 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AMD22293.1 - 0.03 13.7 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI G-alpha PF00503.20 AMD22293.1 - 0.053 12.7 0.0 0.057 12.6 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit SRP54 PF00448.22 AMD22293.1 - 0.063 12.9 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_17 PF13207.6 AMD22293.1 - 0.067 13.6 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 AMD22293.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 AMD22293.1 - 0.085 12.6 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 AMD22293.1 - 0.085 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_22 PF13401.6 AMD22293.1 - 0.099 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 AMD22293.1 - 0.099 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Viral_helicase1 PF01443.18 AMD22293.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 AMD22293.1 - 0.14 11.7 0.0 16 5.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 AMD22293.1 - 0.17 11.7 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 AMD22293.1 - 0.17 11.8 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain MeaB PF03308.16 AMD22293.1 - 0.18 10.8 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Sigma54_activat PF00158.26 AMD22293.1 - 0.2 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain ETF PF01012.21 AMD22294.1 - 1.2e-34 119.8 0.1 2.1e-34 119.0 0.1 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 AMD22294.1 - 3e-33 113.7 0.2 5.8e-33 112.8 0.2 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ATP-synt_F PF01990.17 AMD22295.1 - 4.9e-33 113.3 0.4 5.6e-33 113.1 0.4 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF1882 PF08966.11 AMD22295.1 - 0.06 13.6 0.2 0.11 12.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) DUF2235 PF09994.9 AMD22295.1 - 0.12 11.6 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) SWIRM-assoc_3 PF16498.5 AMD22295.1 - 0.17 12.1 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 SWIRM-associated domain at the C-terminal fn3_2 PF16893.5 AMD22296.1 - 1.3e-35 121.4 0.3 2.6e-35 120.4 0.3 1.6 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 AMD22296.1 - 6.3e-19 67.7 0.6 1.1e-18 66.9 0.6 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 AMD22296.1 - 8e-12 45.4 0.0 1.9e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AMD22296.1 - 4.3e-07 29.8 0.0 8e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain fn3 PF00041.21 AMD22296.1 - 0.0012 19.1 0.0 0.0034 17.7 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.8 AMD22296.1 - 0.0043 17.2 0.1 0.015 15.5 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) LIG3_BRCT PF16759.5 AMD22296.1 - 0.0068 16.7 0.0 0.018 15.3 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 AMD22296.1 - 0.0092 16.4 0.1 0.033 14.6 0.0 2.0 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Pyridox_oxase_2 PF12766.7 AMD22297.1 - 2.5e-30 105.0 0.0 3.8e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 AMD22297.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.6 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase B12D PF06522.11 AMD22298.1 - 0.00011 21.9 0.3 0.00029 20.6 0.3 1.8 1 1 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Glyco_tran_28_C PF04101.16 AMD22299.1 - 2.3e-21 76.5 0.0 4.2e-21 75.6 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Toxin_36 PF10550.9 AMD22299.1 - 0.14 13.5 0.2 0.37 12.2 0.2 1.7 1 0 0 1 1 1 0 Conantokin-G mollusc-toxin AAA PF00004.29 AMD22300.1 - 1.5e-43 148.4 0.0 2.7e-43 147.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD22300.1 - 1.4e-13 50.4 0.7 3.5e-13 49.1 0.1 2.0 3 0 0 3 3 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 AMD22300.1 - 1.1e-06 28.5 1.9 2.4e-06 27.4 1.9 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 AMD22300.1 - 2e-06 27.9 0.0 1.2e-05 25.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 AMD22300.1 - 4.4e-06 26.9 0.0 1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AMD22300.1 - 2.9e-05 24.5 0.0 0.00032 21.1 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AMD22300.1 - 5.4e-05 23.5 0.2 0.0089 16.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 AMD22300.1 - 8e-05 22.4 0.1 0.00022 21.0 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 AMD22300.1 - 0.0012 19.4 0.1 0.018 15.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AMD22300.1 - 0.0014 18.4 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 AMD22300.1 - 0.0023 18.1 0.0 0.0049 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AMD22300.1 - 0.0044 17.3 0.0 0.0087 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AMD22300.1 - 0.006 16.4 0.0 0.019 14.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2072 PF09845.9 AMD22300.1 - 0.0066 16.7 0.2 0.015 15.6 0.2 1.6 1 0 0 1 1 1 1 Zn-ribbon containing protein Mg_chelatase PF01078.21 AMD22300.1 - 0.0085 15.5 0.2 0.028 13.8 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 AMD22300.1 - 0.0092 15.2 0.0 0.028 13.6 0.0 1.8 1 1 0 1 1 1 1 TIP49 P-loop domain PhoH PF02562.16 AMD22300.1 - 0.014 14.8 0.0 0.077 12.4 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 AMD22300.1 - 0.015 15.3 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AMD22300.1 - 0.017 14.8 0.0 0.19 11.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 AMD22300.1 - 0.019 15.0 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 AMD22300.1 - 0.025 14.9 0.2 0.65 10.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AMD22300.1 - 0.029 14.8 0.0 0.093 13.1 0.0 2.0 1 1 1 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 AMD22300.1 - 0.034 13.9 0.0 0.17 11.6 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF3372 PF11852.8 AMD22300.1 - 0.05 13.1 0.1 0.092 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) AAA_25 PF13481.6 AMD22300.1 - 0.052 13.1 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AMD22300.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 AMD22300.1 - 0.083 12.0 0.0 0.19 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 AMD22300.1 - 0.098 11.9 0.0 0.25 10.6 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 AMD22300.1 - 0.1 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 AMD22300.1 - 0.1 12.3 0.0 0.33 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain MIF4G PF02854.19 AMD22301.1 - 5.9e-44 150.2 0.1 1e-43 149.4 0.1 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 AMD22301.1 - 7.9e-21 74.0 0.3 3e-20 72.2 0.3 2.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 LTD PF00932.19 AMD22301.1 - 0.1 13.0 0.1 0.33 11.3 0.1 1.8 1 0 0 1 1 1 0 Lamin Tail Domain TYW3 PF02676.14 AMD22302.1 - 2.8e-63 213.1 0.0 4.2e-63 212.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 Gtr1_RagA PF04670.12 AMD22303.1 - 1.4e-66 224.1 0.8 1.9e-66 223.8 0.8 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 AMD22303.1 - 0.003 17.1 0.2 0.011 15.2 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_cyclohydro2 PF00925.20 AMD22303.1 - 0.031 13.9 0.0 0.068 12.8 0.0 1.6 1 0 0 1 1 1 0 GTP cyclohydrolase II AAA_14 PF13173.6 AMD22303.1 - 0.034 14.2 0.0 0.079 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain ELFV_dehydrog PF00208.21 AMD22304.1 - 2.9e-65 220.4 0.0 5.5e-65 219.5 0.0 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 AMD22304.1 - 1.6e-18 65.8 0.0 8.8e-13 46.7 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 AMD22304.1 - 0.015 15.2 0.0 0.051 13.5 0.0 1.9 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain FAST_1 PF06743.15 AMD22304.1 - 0.057 13.4 0.2 0.27 11.2 0.1 2.2 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 NPR3 PF03666.13 AMD22305.1 - 8.3e-160 532.6 0.0 8.3e-160 532.6 0.0 2.2 3 0 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 AMD22305.1 - 0.055 12.2 0.3 1.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Nitrogen permease regulator 2 RRM_1 PF00076.22 AMD22306.1 - 9.4e-31 105.5 3.1 6.8e-14 51.4 0.2 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 AMD22306.1 - 0.0082 16.1 0.0 0.075 13.0 0.0 2.5 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 AMD22306.1 - 0.019 15.0 0.5 13 5.9 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 AMD22306.1 - 0.02 14.9 5.8 2.2 8.4 0.3 3.1 2 1 1 3 3 3 0 RNA binding motif RRM_5 PF13893.6 AMD22306.1 - 0.085 12.5 0.0 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myc_N PF01056.18 AMD22306.1 - 1.3 8.9 11.1 0.27 11.1 3.6 2.4 2 0 0 2 2 2 0 Myc amino-terminal region AAA_2 PF07724.14 AMD22307.1 - 1.6e-45 155.3 0.1 4.2e-44 150.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AMD22307.1 - 1.8e-27 95.3 0.2 1.8e-27 95.3 0.2 3.5 2 1 1 3 3 3 1 AAA lid domain ClpB_D2-small PF10431.9 AMD22307.1 - 6.3e-25 87.0 0.4 2.6e-24 85.1 0.4 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 AMD22307.1 - 1.5e-24 86.9 0.3 4.5e-14 53.0 0.1 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AMD22307.1 - 1.1e-15 57.9 0.0 2.4e-08 34.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 AMD22307.1 - 4.6e-13 49.1 2.3 6.1e-06 26.3 0.1 3.3 2 1 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 AMD22307.1 - 3.2e-12 46.5 0.1 4.2e-08 33.1 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 AMD22307.1 - 1.5e-08 35.2 6.5 0.00062 20.2 0.1 4.6 4 1 0 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 AMD22307.1 - 1.3e-07 31.9 0.9 0.059 13.7 0.1 4.2 2 2 0 2 2 2 2 AAA domain TniB PF05621.11 AMD22307.1 - 3e-06 26.8 0.1 0.0014 18.1 0.1 3.9 2 1 0 2 2 2 1 Bacterial TniB protein TIP49 PF06068.13 AMD22307.1 - 7.1e-06 25.5 2.5 0.056 12.6 0.0 3.5 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_14 PF13173.6 AMD22307.1 - 3.5e-05 23.8 0.0 0.14 12.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 AMD22307.1 - 0.00025 20.5 0.0 1.2 8.5 0.0 3.5 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 AMD22307.1 - 0.00044 20.0 0.1 0.67 9.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 AMD22307.1 - 0.00056 19.5 0.1 0.86 9.1 0.0 2.9 3 1 0 3 3 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 AMD22307.1 - 0.0016 18.6 0.0 0.19 11.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AMD22307.1 - 0.002 18.1 0.0 1.2 9.0 0.0 2.9 2 0 0 2 2 2 1 NACHT domain AAA_3 PF07726.11 AMD22307.1 - 0.0021 17.9 0.0 0.68 9.8 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 AMD22307.1 - 0.007 16.1 0.1 1.2 8.9 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein NTPase_1 PF03266.15 AMD22307.1 - 0.0077 16.2 0.1 4.9 7.0 0.0 3.6 3 0 0 3 3 3 1 NTPase Zeta_toxin PF06414.12 AMD22307.1 - 0.0087 15.4 0.0 0.41 9.9 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin Torsin PF06309.11 AMD22307.1 - 0.018 15.1 0.0 0.09 12.9 0.0 2.1 2 0 0 2 2 1 0 Torsin TsaE PF02367.17 AMD22307.1 - 0.02 14.9 0.0 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 AMD22307.1 - 0.02 15.2 0.8 0.32 11.3 0.1 3.0 2 2 0 2 2 2 0 AAA domain PEPCK_ATP PF01293.20 AMD22307.1 - 0.026 13.2 0.0 0.049 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase Roc PF08477.13 AMD22307.1 - 0.034 14.3 0.0 11 6.3 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 AMD22307.1 - 0.18 12.2 0.1 15 6.0 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Spc7 PF08317.11 AMD22307.1 - 0.2 10.5 16.0 0.36 9.7 16.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein ATPase_2 PF01637.18 AMD22307.1 - 0.44 10.4 10.7 5.4 6.9 0.3 4.3 4 2 1 5 5 4 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 AMD22307.1 - 0.72 10.4 4.4 14 6.2 0.0 3.4 3 0 0 3 3 3 0 ABC transporter Atg14 PF10186.9 AMD22307.1 - 3.2 6.8 10.8 6.5 5.7 10.8 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sod_Cu PF00080.20 AMD22308.1 - 6.8e-10 39.3 0.0 1.2e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Fe-S_biosyn PF01521.20 AMD22309.1 - 6.8e-18 64.9 0.0 1.1e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3418 PF11898.8 AMD22309.1 - 0.024 13.3 0.0 0.039 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) Creatinase_N_2 PF16189.5 AMD22310.1 - 3.5e-41 141.0 0.1 8.2e-41 139.8 0.1 1.6 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 AMD22310.1 - 2.2e-40 138.6 0.0 3.6e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 AMD22310.1 - 2e-20 72.6 0.4 5.5e-20 71.2 0.4 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 AMD22310.1 - 3.1e-11 44.0 0.0 6.7e-10 39.7 0.0 2.5 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Cofilin_ADF PF00241.20 AMD22311.1 - 7e-17 61.4 0.1 8e-17 61.2 0.1 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S13_N PF08069.12 AMD22312.1 - 4.2e-28 97.2 0.3 7.9e-28 96.3 0.3 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 AMD22312.1 - 4.9e-15 55.5 0.4 8.8e-15 54.7 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein S15 Lipoprotein_Ltp PF07553.11 AMD22314.1 - 0.12 12.6 0.0 0.41 11.0 0.0 1.9 1 0 0 1 1 1 0 Host cell surface-exposed lipoprotein WD40 PF00400.32 AMD22315.1 - 8.1e-35 118.3 21.2 1.1e-05 26.1 0.7 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat CDC4_D PF16856.5 AMD22315.1 - 2.3e-20 72.2 3.5 5.9e-20 70.9 3.5 1.7 1 0 0 1 1 1 1 Cell division control protein 4 dimerisation domain F-box-like PF12937.7 AMD22315.1 - 1.7e-08 34.2 0.1 3.8e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AMD22315.1 - 2e-07 30.7 2.0 4.6e-07 29.6 0.4 2.3 1 1 1 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 AMD22315.1 - 1.8e-05 24.9 0.3 0.13 12.5 0.1 4.6 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PRANC PF09372.10 AMD22315.1 - 0.00014 22.1 1.9 0.0007 19.9 0.1 2.8 3 0 0 3 3 3 1 PRANC domain WD40_like PF17005.5 AMD22315.1 - 0.0075 15.6 1.8 5.9 6.1 0.0 3.2 3 0 0 3 3 3 1 WD40-like domain Nup160 PF11715.8 AMD22315.1 - 0.026 13.2 5.6 1.4 7.5 0.1 4.4 2 2 3 5 5 5 0 Nucleoporin Nup120/160 CNH PF00780.22 AMD22315.1 - 0.028 14.0 0.0 0.067 12.8 0.0 1.6 1 1 0 1 1 1 0 CNH domain 7TM_GPCR_Srsx PF10320.9 AMD22316.1 - 0.082 12.3 4.1 0.12 11.8 4.0 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx SieB PF14163.6 AMD22316.1 - 0.21 11.1 3.9 0.71 9.4 3.9 1.7 1 1 0 1 1 1 0 Super-infection exclusion protein B SMC_N PF02463.19 AMD22317.1 - 3.7e-59 199.8 24.5 1.2e-58 198.2 24.5 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AMD22317.1 - 8.8e-25 87.3 1.3 2.4e-24 85.9 0.0 2.4 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 AMD22317.1 - 9.3e-14 52.4 12.6 9.3e-14 52.4 12.6 6.5 2 2 1 4 4 2 1 AAA domain AAA_21 PF13304.6 AMD22317.1 - 7.7e-12 45.6 6.1 3.6e-05 23.7 0.1 3.6 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AMD22317.1 - 4.3e-08 32.8 0.1 1e-07 31.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AMD22317.1 - 2.8e-06 27.3 22.2 2.8e-06 27.3 22.2 4.6 2 2 2 4 4 1 1 AAA ATPase domain TPR_MLP1_2 PF07926.12 AMD22317.1 - 0.0013 18.7 20.3 0.0013 18.7 20.3 7.4 5 3 2 7 7 7 2 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 AMD22317.1 - 0.0029 18.1 11.0 0.0029 18.1 11.0 6.0 2 2 4 6 6 5 1 Fez1 HrpB7 PF09486.10 AMD22317.1 - 0.017 15.5 1.5 0.017 15.5 1.5 6.5 5 1 2 7 7 6 0 Bacterial type III secretion protein (HrpB7) SlyX PF04102.12 AMD22317.1 - 0.026 15.1 0.4 0.026 15.1 0.4 9.2 8 2 3 11 11 11 0 SlyX FlaC_arch PF05377.11 AMD22317.1 - 0.057 13.8 0.4 0.057 13.8 0.4 9.5 10 2 2 12 12 10 0 Flagella accessory protein C (FlaC) SbcCD_C PF13558.6 AMD22317.1 - 0.074 13.3 0.0 0.31 11.3 0.0 2.1 2 0 0 2 2 1 0 Putative exonuclease SbcCD, C subunit R_equi_Vir PF05526.11 AMD22317.1 - 0.18 11.7 0.0 0.48 10.3 0.0 1.7 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein DUF4407 PF14362.6 AMD22317.1 - 4.3 6.6 55.2 0.027 13.8 11.4 5.9 3 2 2 5 5 5 0 Domain of unknown function (DUF4407) DUF812 PF05667.11 AMD22317.1 - 8.6 5.1 88.1 0.083 11.8 10.5 5.6 4 1 0 4 4 3 0 Protein of unknown function (DUF812) BLM10_mid PF16507.5 AMD22318.1 - 5.3e-159 530.2 13.2 5.3e-159 530.2 13.2 2.6 3 1 1 4 4 4 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 AMD22318.1 - 7e-32 109.6 1.3 1.9e-31 108.2 1.3 1.8 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal DUF3437 PF11919.8 AMD22318.1 - 2.9e-25 88.0 0.0 1.5e-24 85.7 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HBD PF18534.1 AMD22318.1 - 0.014 15.5 0.4 8.2 6.6 0.0 3.0 2 0 0 2 2 2 0 Helical bundle domain Ras PF00071.22 AMD22319.1 - 2e-61 206.3 0.6 2.4e-61 206.1 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22319.1 - 1.1e-35 122.5 0.2 1.6e-35 121.9 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD22319.1 - 1.1e-18 67.3 0.1 1.3e-18 67.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD22319.1 - 1.7e-07 30.9 0.2 2e-07 30.6 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AMD22319.1 - 2.1e-07 30.7 0.1 1.5e-06 27.9 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AMD22319.1 - 2e-06 27.8 0.4 0.058 13.3 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AMD22319.1 - 3.6e-06 27.0 0.1 7.4e-06 26.0 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 AMD22319.1 - 1e-05 25.1 0.1 1.3e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 AMD22319.1 - 0.00028 20.5 0.1 0.0016 18.0 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.29 AMD22319.1 - 0.0066 16.9 0.1 0.17 12.3 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 AMD22319.1 - 0.014 14.9 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region MCM PF00493.23 AMD22319.1 - 0.02 14.0 0.1 0.068 12.3 0.0 1.8 1 1 0 2 2 2 0 MCM P-loop domain AAA_22 PF13401.6 AMD22319.1 - 0.039 14.2 0.1 0.25 11.6 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 AMD22319.1 - 0.047 13.4 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 AMD22319.1 - 0.048 12.9 0.1 0.11 11.8 0.1 1.5 1 0 0 1 1 1 0 Septin DUF815 PF05673.13 AMD22319.1 - 0.048 12.8 0.0 0.15 11.2 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF815) TniB PF05621.11 AMD22319.1 - 0.11 11.9 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 AMD22319.1 - 0.14 12.5 0.1 0.2 12.0 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 AMD22319.1 - 0.16 12.5 0.3 0.42 11.1 0.3 2.0 1 1 0 1 1 1 0 ABC transporter Peptidase_C48 PF02902.19 AMD22320.1 - 4.6e-34 118.1 0.2 4.6e-34 118.1 0.2 2.0 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain SIR2 PF02146.17 AMD22321.1 - 6.3e-54 182.6 0.0 9.1e-54 182.0 0.0 1.2 1 0 0 1 1 1 1 Sir2 family RVT_1 PF00078.27 AMD22322.1 - 7.6e-26 91.0 0.0 2.1e-25 89.6 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 AMD22322.1 - 1.3e-25 89.7 0.0 3.6e-25 88.3 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 AMD22322.1 - 4.3e-25 87.7 0.0 1.4e-24 86.1 0.0 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 AMD22322.1 - 2e-22 79.1 0.3 5.7e-22 77.6 0.3 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 AMD22322.1 - 7.1e-14 52.0 0.0 3e-13 50.0 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 AMD22322.1 - 1e-05 25.3 1.3 2e-05 24.5 1.3 1.5 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.6 AMD22322.1 - 1.6e-05 25.4 0.0 5e-05 23.8 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AMD22322.1 - 3.3e-05 24.4 0.1 8.1e-05 23.2 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-H2C2 PF09337.10 AMD22322.1 - 4.9e-05 23.4 0.0 0.00017 21.7 0.0 2.0 1 0 0 1 1 1 1 H2C2 zinc finger DUF4258 PF14076.6 AMD22322.1 - 0.14 12.5 0.0 0.5 10.8 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) NFACT-C PF11923.8 AMD22323.1 - 6.4e-31 106.4 0.6 6.4e-31 106.4 0.6 3.6 3 1 1 4 4 4 1 NFACT protein C-terminal domain FbpA PF05833.11 AMD22323.1 - 4.4e-26 91.7 24.9 4.4e-26 91.7 24.9 3.4 2 2 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 AMD22323.1 - 1.8e-13 51.1 0.0 6.1e-13 49.4 0.0 2.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain Clat_adaptor_s PF01217.20 AMD22324.1 - 1.7e-12 47.5 3.9 3.1e-12 46.6 3.9 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Bromo_TP PF07524.13 AMD22325.1 - 9e-07 28.8 0.3 2.4e-06 27.5 0.1 1.8 2 0 0 2 2 2 1 Bromodomain associated TFIID-31kDa PF02291.15 AMD22325.1 - 0.042 13.9 0.1 0.12 12.5 0.1 1.7 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit NUC173 PF08161.12 AMD22326.1 - 3.3e-68 229.4 3.9 2.9e-66 223.0 0.0 4.4 5 0 0 5 5 5 2 NUC173 domain HEAT PF02985.22 AMD22326.1 - 0.018 15.2 0.4 16 6.1 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat Vac14_Fab1_bd PF12755.7 AMD22326.1 - 0.081 13.5 0.4 1.1e+02 3.5 0.0 4.9 5 1 0 5 5 5 0 Vacuolar 14 Fab1-binding region Spore_coat_CotO PF14153.6 AMD22326.1 - 0.36 10.7 4.5 4.8 7.1 2.3 2.3 2 0 0 2 2 2 0 Spore coat protein CotO Ribosomal_S16 PF00886.19 AMD22327.1 - 1.3e-18 66.8 0.1 1.8e-18 66.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 Helicase_C_2 PF13307.6 AMD22330.1 - 1e-49 169.0 0.0 2.7e-49 167.6 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 AMD22330.1 - 1.1e-47 161.9 2.5 1.8e-47 161.3 2.5 1.3 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 AMD22330.1 - 1.1e-06 28.8 0.2 0.0057 16.7 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit PhoH PF02562.16 AMD22330.1 - 0.002 17.6 0.1 0.33 10.4 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein DEAD PF00270.29 AMD22330.1 - 0.0031 17.3 0.0 0.012 15.4 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AMD22330.1 - 0.065 13.5 0.1 2.6 8.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain zf-TFIIIC PF12660.7 AMD22331.1 - 7.5e-08 32.3 0.0 3.3e-07 30.2 0.0 2.0 1 1 1 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex ANAPC4_WD40 PF12894.7 AMD22331.1 - 6.3e-07 29.6 0.0 2.1e-05 24.7 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 AMD22331.1 - 0.002 18.0 0.2 7 6.7 0.0 3.6 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat WD40 PF00400.32 AMD22331.1 - 0.034 15.0 0.3 3.6 8.6 0.0 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat NPC1_N PF16414.5 AMD22332.1 - 4e-79 265.6 10.8 8.3e-79 264.6 10.8 1.5 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 AMD22332.1 - 2.7e-50 171.3 22.5 4.9e-30 104.3 8.5 2.8 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 AMD22332.1 - 8.3e-40 136.1 12.1 8.3e-40 136.1 12.1 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Folate_rec PF03024.14 AMD22332.1 - 5.3e-05 23.2 0.7 0.00014 21.8 0.7 1.6 1 0 0 1 1 1 1 Folate receptor family MMPL PF03176.15 AMD22332.1 - 0.00017 20.6 4.3 0.00017 20.6 4.3 2.5 2 0 0 2 2 2 1 MMPL family PPR_2 PF13041.6 AMD22333.1 - 1.9e-12 47.2 5.8 2.9e-06 27.4 0.8 4.4 3 1 1 4 4 4 4 PPR repeat family PPR_3 PF13812.6 AMD22333.1 - 9e-08 32.1 4.0 0.00015 21.8 0.1 3.3 3 0 0 3 3 3 2 Pentatricopeptide repeat domain COX5A PF02284.16 AMD22333.1 - 0.26 11.3 1.6 28 4.8 0.1 3.2 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Va PPR PF01535.20 AMD22333.1 - 1.8 9.0 9.0 1.2 9.6 0.1 4.3 5 0 0 5 5 5 0 PPR repeat Pil1 PF13805.6 AMD22334.1 - 4.4e-124 413.2 0.3 5e-124 413.0 0.3 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.10 AMD22334.1 - 0.025 14.8 0.4 0.18 12.1 0.4 2.4 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit ThiF PF00899.21 AMD22335.1 - 4.9e-09 35.9 0.1 5.9e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 ThiF family DEAD PF00270.29 AMD22336.1 - 2.4e-39 134.9 0.0 4.2e-39 134.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22336.1 - 3.6e-23 82.0 0.2 3.3e-22 78.9 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AMD22336.1 - 5.1e-14 52.2 0.1 1.2e-13 51.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AMD22336.1 - 2.3e-07 31.0 0.3 8.5e-07 29.1 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 AMD22336.1 - 0.015 14.8 4.3 0.096 12.2 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain PAS_12 PF18095.1 AMD22336.1 - 0.021 14.4 1.5 0.059 13.0 1.5 1.7 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain ERCC3_RAD25_C PF16203.5 AMD22336.1 - 0.034 13.4 0.0 0.034 13.4 0.0 2.1 3 0 0 3 3 3 0 ERCC3/RAD25/XPB C-terminal helicase PseudoU_synth_1 PF01416.20 AMD22337.1 - 3.7e-31 107.8 0.0 8.1e-29 100.3 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase EAP30 PF04157.16 AMD22338.1 - 1.1e-52 178.7 0.0 1.2e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Hat1_N PF10394.9 AMD22339.1 - 2e-43 148.4 0.5 2e-43 148.4 0.5 1.6 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 AMD22339.1 - 0.014 15.6 0.0 0.032 14.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AMD22339.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CCDC-167 PF15188.6 AMD22340.1 - 0.56 10.6 11.3 0.083 13.2 7.0 1.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 MmgE_PrpD PF03972.14 AMD22341.1 - 7.7e-132 439.9 0.0 9.3e-132 439.7 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Nic96 PF04097.14 AMD22342.1 - 9.2e-207 688.3 9.7 1.3e-206 687.8 9.7 1.1 1 0 0 1 1 1 1 Nup93/Nic96 ANAPC3 PF12895.7 AMD22342.1 - 0.034 14.4 0.6 7.5 6.9 0.0 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 XET_C PF06955.12 AMD22342.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.8 1 0 0 1 1 1 0 Xyloglucan endo-transglycosylase (XET) C-terminus Gal4_dimer PF03902.13 AMD22342.1 - 0.25 11.5 4.6 5.1 7.3 0.5 2.8 2 0 0 2 2 2 0 Gal4-like dimerisation domain PPI_Ypi1 PF07491.11 AMD22343.1 - 1.9e-20 72.5 16.0 1.1e-19 70.0 16.0 2.2 1 1 0 1 1 1 1 Protein phosphatase inhibitor CDC45 PF02724.14 AMD22343.1 - 1.2 7.3 13.0 1.3 7.2 13.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2220 PF09983.9 AMD22343.1 - 1.6 8.1 5.2 2.8 7.3 5.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) DUF4724 PF15852.5 AMD22343.1 - 6.5 7.3 8.4 1.4 9.5 2.8 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4724) JAB PF01398.21 AMD22344.1 - 6.2e-31 106.8 0.1 6.2e-31 106.8 0.1 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 AMD22344.1 - 3e-11 43.7 1.3 3e-11 43.7 1.3 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 AMD22344.1 - 1.7e-07 31.0 0.0 2.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UCH PF00443.29 AMD22345.1 - 4.3e-13 49.4 5.3 2e-12 47.2 5.3 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AMD22345.1 - 1.2e-08 35.2 0.0 2.3e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_M24 PF00557.24 AMD22346.1 - 1.7e-57 194.5 0.0 2.2e-57 194.1 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 AMD22346.1 - 1.7e-22 79.4 0.0 4e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain RVT_1 PF00078.27 AMD22347.1 - 6.9e-26 91.1 0.0 1.7e-25 89.8 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 AMD22347.1 - 1.1e-25 90.0 0.0 3e-25 88.5 0.0 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 AMD22347.1 - 3.4e-25 88.0 0.0 1.1e-24 86.3 0.0 2.0 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 AMD22347.1 - 1.7e-22 79.3 0.3 4.9e-22 77.8 0.3 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 AMD22347.1 - 5.2e-14 52.5 0.0 2.5e-13 50.2 0.0 2.2 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 AMD22347.1 - 9.1e-06 25.5 1.3 1.7e-05 24.7 1.3 1.5 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.6 AMD22347.1 - 1.4e-05 25.6 0.0 4.2e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AMD22347.1 - 2.8e-05 24.7 0.1 6.9e-05 23.4 0.1 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-H2C2 PF09337.10 AMD22347.1 - 4.4e-05 23.6 0.0 0.00015 21.9 0.0 2.0 1 0 0 1 1 1 1 H2C2 zinc finger DUF4258 PF14076.6 AMD22347.1 - 0.14 12.6 0.0 0.43 11.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) CSTF2_hinge PF14327.6 AMD22348.1 - 1.3e-19 70.4 5.4 1.5e-19 70.2 3.0 2.4 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 AMD22348.1 - 2.8e-07 30.0 2.8 6.7e-06 25.6 1.9 2.5 1 1 1 2 2 2 2 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.22 AMD22348.1 - 0.097 12.5 0.0 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 AMD22349.1 - 5e-19 67.9 0.0 1.1e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 AMD22349.1 - 5.7e-12 45.0 0.8 1.3e-11 43.9 0.8 1.7 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.6 AMD22349.1 - 1.6e-08 34.8 0.8 1.6e-08 34.8 0.8 1.8 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_occluded PF16842.5 AMD22349.1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif TFIIS_M PF07500.14 AMD22350.1 - 1.6e-25 89.8 1.2 1.6e-25 89.8 1.2 2.4 2 1 1 3 3 3 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 AMD22350.1 - 3e-17 62.2 6.4 4.8e-17 61.5 6.4 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 AMD22350.1 - 2e-09 37.3 3.2 2e-09 37.3 3.2 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain IML1 PF12257.8 AMD22350.1 - 0.0063 15.7 4.0 0.28 10.3 0.1 2.1 2 0 0 2 2 2 2 Vacuolar membrane-associated protein Iml1 SR-25 PF10500.9 AMD22350.1 - 0.018 14.6 10.6 0.03 13.9 10.6 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 AMD22350.1 - 0.1 12.6 5.2 0.22 11.6 5.2 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Ad_Cy_reg PF16701.5 AMD22350.1 - 0.15 11.8 0.1 0.25 11.1 0.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase regulatory domain FpoO PF10621.9 AMD22350.1 - 0.24 11.7 4.3 0.44 10.9 0.2 2.4 2 0 0 2 2 2 0 F420H2 dehydrogenase subunit FpoO NPHI_C PF08469.10 AMD22350.1 - 4 7.4 7.3 1 9.3 2.7 2.0 2 0 0 2 2 2 0 Nucleoside triphosphatase I C-terminal OmdA PF13376.6 AMD22351.1 - 0.048 13.7 0.1 0.11 12.5 0.0 1.6 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated DUF1641 PF07849.11 AMD22351.1 - 0.052 13.4 0.1 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1641) ComZ PF10815.8 AMD22351.1 - 0.13 12.3 0.1 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 ComZ PALP PF00291.25 AMD22352.1 - 7.6e-63 212.7 0.0 9.5e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 AMD22352.1 - 1.1e-18 67.4 0.1 3.6e-12 46.5 0.1 2.7 2 0 0 2 2 2 2 CBS domain GSCFA PF08885.11 AMD22352.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 GSCFA family Snf7 PF03357.21 AMD22353.1 - 3.5e-33 114.6 8.3 4.3e-33 114.3 8.3 1.1 1 0 0 1 1 1 1 Snf7 DUF2451 PF10474.9 AMD22353.1 - 0.0028 17.5 0.2 0.005 16.7 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) YtxH PF12732.7 AMD22353.1 - 0.24 12.0 4.5 1.8 9.2 0.9 2.5 2 0 0 2 2 2 0 YtxH-like protein ALAD PF00490.21 AMD22354.1 - 9.1e-116 386.4 0.0 1.1e-115 386.2 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase PITH PF06201.13 AMD22355.1 - 3.6e-36 124.7 0.1 4.9e-36 124.2 0.1 1.2 1 0 0 1 1 1 1 PITH domain YycI PF09648.10 AMD22356.1 - 0.1 12.2 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 YycH protein EF-hand_like PF09279.11 AMD22357.1 - 0.11 13.0 0.0 0.19 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like AvrPtoB_bdg PF16847.5 AMD22357.1 - 0.11 12.9 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 Avirulence AvrPtoB, BAK1-binding domain DUF4870 PF09685.10 AMD22357.1 - 0.26 11.4 5.6 0.36 10.9 5.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4870) DUF4040 PF13244.6 AMD22357.1 - 1.3 9.2 5.0 0.34 11.1 0.9 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4040) PWI PF01480.17 AMD22359.1 - 0.0077 16.5 0.3 0.026 14.8 0.3 1.9 1 0 0 1 1 1 1 PWI domain FOP_dimer PF09398.10 AMD22359.1 - 0.016 15.4 0.1 0.061 13.6 0.1 2.0 1 0 0 1 1 1 0 FOP N terminal dimerisation domain PALP PF00291.25 AMD22360.1 - 1.1e-68 231.8 0.0 1.3e-68 231.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CTP_transf_like PF01467.26 AMD22361.1 - 1.2e-30 106.5 0.0 1.8e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like UCH PF00443.29 AMD22362.1 - 2.7e-40 138.5 0.1 4.9e-40 137.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AMD22362.1 - 8.4e-21 74.1 5.0 8.4e-21 74.1 5.0 3.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 AMD22362.1 - 6.5e-15 55.5 0.1 6.5e-15 55.5 0.1 2.9 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 AMD22362.1 - 2e-14 53.1 0.2 1.6e-11 43.9 0.0 3.0 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP_var PF17807.1 AMD22362.1 - 1.6e-08 34.2 13.0 6.3e-07 29.1 6.8 3.4 2 1 0 2 2 2 2 Variant UBP zinc finger DUF5390 PF17365.2 AMD22362.1 - 0.019 15.3 0.1 0.049 13.9 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5390) DUF2180 PF09947.9 AMD22362.1 - 0.37 10.8 0.0 0.37 10.8 0.0 3.1 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2180) zf-C2HC5 PF06221.13 AMD22362.1 - 2.9 7.9 8.0 7.3 6.7 2.1 3.7 3 0 0 3 3 3 0 Putative zinc finger motif, C2HC5-type zf-BED PF02892.15 AMD22362.1 - 8.8 6.4 9.6 62 3.7 2.8 4.0 3 0 0 3 3 3 0 BED zinc finger ECH_2 PF16113.5 AMD22363.1 - 4.1e-93 312.5 0.0 5.1e-93 312.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 AMD22363.1 - 2.5e-28 99.1 0.0 4.2e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SPT_ssu-like PF11779.8 AMD22364.1 - 0.067 12.8 7.3 0.11 12.1 7.3 1.3 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like Pkinase PF00069.25 AMD22365.1 - 4.4e-39 134.4 0.1 1e-38 133.3 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22365.1 - 1.8e-27 96.3 0.0 3e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD22365.1 - 0.00038 19.5 1.1 0.00068 18.7 0.1 1.9 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 AMD22365.1 - 0.2 11.6 0.1 0.74 9.7 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family ORC2 PF04084.14 AMD22366.1 - 2.2e-102 342.4 0.2 2.7e-102 342.1 0.2 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 AT_hook PF02178.19 AMD22366.1 - 0.12 12.4 4.8 0.26 11.3 4.8 1.6 1 0 0 1 1 1 0 AT hook motif TFIIS_C PF01096.18 AMD22367.1 - 2.3e-22 78.5 1.3 2.3e-22 78.5 1.3 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 AMD22367.1 - 5.9e-11 42.1 3.9 2.4e-10 40.1 1.3 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit DZR PF12773.7 AMD22367.1 - 0.0045 17.0 6.4 0.026 14.5 0.3 2.6 2 1 0 2 2 2 1 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 AMD22367.1 - 0.096 12.7 8.7 0.21 11.6 0.2 3.0 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zf-WRNIP1_ubi PF18279.1 AMD22367.1 - 0.12 13.1 1.5 2.6 8.9 0.0 3.0 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Zn_ribbon_SprT PF17283.2 AMD22367.1 - 0.19 11.7 5.7 8.9 6.3 0.8 3.3 3 0 0 3 3 3 0 SprT-like zinc ribbon domain IBR PF01485.21 AMD22367.1 - 0.27 11.5 9.0 0.3 11.3 0.5 2.6 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf_C2H2_10 PF18414.1 AMD22367.1 - 1.7 8.3 6.8 16 5.2 0.3 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger zf-NADH-PPase PF09297.11 AMD22367.1 - 3.5 7.4 0.0 3.5 7.4 0.0 3.5 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain TF_Zn_Ribbon PF08271.12 AMD22367.1 - 4.9 6.8 11.9 1.2 8.7 0.7 3.2 2 2 1 3 3 3 0 TFIIB zinc-binding Coprogen_oxidas PF01218.18 AMD22368.1 - 5.3e-136 452.1 0.0 6e-136 452.0 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase zf-H2C2_2 PF13465.6 AMD22369.1 - 0.0013 19.1 3.6 0.0013 19.1 3.6 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 AMD22369.1 - 0.0044 17.4 5.5 0.0044 17.4 5.5 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 AMD22369.1 - 0.0044 16.7 3.5 0.0044 16.7 3.5 1.9 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 AMD22369.1 - 0.19 12.6 17.5 1.4 9.9 3.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger FYVE PF01363.21 AMD22369.1 - 0.45 10.7 14.6 2.7 8.2 14.6 2.1 1 1 0 1 1 1 0 FYVE zinc finger zinc_ribbon_10 PF10058.9 AMD22370.1 - 0.0035 17.0 4.9 1.9 8.3 2.4 3.6 3 0 0 3 3 3 3 Predicted integral membrane zinc-ribbon metal-binding protein KCT2 PF17818.1 AMD22371.1 - 0.04 14.0 0.3 0.068 13.3 0.1 1.5 1 1 0 1 1 1 0 Keratinocyte-associated gene product zf-RING_2 PF13639.6 AMD22372.1 - 1.8e-09 37.8 10.9 2.7e-09 37.2 10.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AMD22372.1 - 7.2e-08 32.6 10.8 2.3e-07 31.0 10.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AMD22372.1 - 1.8e-05 24.7 7.8 4.1e-05 23.5 7.5 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 AMD22372.1 - 0.00036 20.3 11.3 0.00056 19.7 11.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD22372.1 - 0.00047 20.1 9.1 0.0009 19.2 9.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AMD22372.1 - 0.002 17.9 12.3 0.0039 17.0 12.3 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD22372.1 - 0.0045 16.8 9.5 0.0092 15.8 9.5 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AMD22372.1 - 0.012 15.5 8.2 0.019 14.9 8.2 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 AMD22372.1 - 0.013 15.2 8.6 0.03 14.1 8.6 1.6 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 AMD22372.1 - 0.014 15.2 9.0 0.035 14.0 9.3 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Lys PF00062.20 AMD22372.1 - 0.054 13.7 2.2 0.093 13.0 2.2 1.4 1 0 0 1 1 1 0 C-type lysozyme/alpha-lactalbumin family zf-C3HC4_4 PF15227.6 AMD22372.1 - 0.38 11.0 10.7 0.91 9.7 10.7 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 AMD22372.1 - 0.51 10.5 8.4 4.8 7.4 8.4 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Ribosomal_S10 PF00338.22 AMD22373.1 - 7.8e-31 106.2 0.0 2.2e-30 104.8 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e FtsJ PF01728.19 AMD22374.1 - 1.9e-68 230.0 0.0 2.4e-68 229.7 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 AMD22374.1 - 0.066 13.0 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain tRNA-synt_2 PF00152.20 AMD22375.1 - 5.5e-76 255.6 0.5 8.3e-76 255.1 0.5 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AMD22375.1 - 1.8e-11 43.8 0.2 9.4e-11 41.6 0.1 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AMD22375.1 - 7.7e-08 32.1 0.1 0.00066 19.2 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) CRR7 PF12095.8 AMD22375.1 - 0.091 13.2 0.1 3.4 8.2 0.0 3.1 3 0 0 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 AA_permease PF00324.21 AMD22376.1 - 2.2e-116 389.3 40.5 2.5e-116 389.1 40.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD22376.1 - 1.3e-32 113.2 40.3 1.8e-32 112.7 40.3 1.1 1 0 0 1 1 1 1 Amino acid permease Nodulin_late PF07127.11 AMD22376.1 - 4.3 7.8 5.3 2.1 8.7 1.6 2.5 2 0 0 2 2 2 0 Late nodulin protein AA_permease PF00324.21 AMD22377.1 - 3.9e-122 408.3 26.7 4.9e-122 408.0 26.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD22377.1 - 1.1e-30 106.9 27.9 1.3e-30 106.6 27.9 1.0 1 0 0 1 1 1 1 Amino acid permease Claudin_3 PF06653.11 AMD22377.1 - 0.02 14.8 0.9 0.02 14.8 0.9 2.5 2 0 0 2 2 2 0 Tight junction protein, Claudin-like Cas9_REC PF16592.5 AMD22377.1 - 0.049 12.4 0.4 0.073 11.8 0.4 1.1 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 Ndc1_Nup PF09531.10 AMD22377.1 - 0.81 8.3 7.0 4 6.0 0.2 2.3 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup AA_permease PF00324.21 AMD22378.1 - 2.2e-131 438.8 42.9 2.5e-131 438.6 42.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AMD22378.1 - 3.4e-37 128.3 43.0 4.2e-37 128.0 43.0 1.1 1 0 0 1 1 1 1 Amino acid permease Vma12 PF11712.8 AMD22378.1 - 0.12 12.5 1.6 5.7 7.0 0.0 2.9 1 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4781 PF16013.5 AMD22378.1 - 0.18 10.6 1.1 0.31 9.8 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) TPPK_C PF12555.8 AMD22378.1 - 0.24 11.5 4.7 0.52 10.4 0.3 2.9 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal TIM PF00121.18 AMD22380.1 - 2.9e-91 305.2 0.3 3.2e-91 305.0 0.3 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase MreB_Mbl PF06723.13 AMD22380.1 - 0.028 13.3 0.1 0.35 9.6 0.0 2.4 2 1 1 3 3 3 0 MreB/Mbl protein Alg14 PF08660.11 AMD22381.1 - 4.7e-52 176.4 0.0 6.5e-52 176.0 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like UQ_con PF00179.26 AMD22382.1 - 6.9e-44 148.9 0.0 9e-44 148.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AMD22382.1 - 0.015 15.0 0.0 0.039 13.7 0.0 1.7 1 1 0 1 1 1 0 Prokaryotic E2 family B AMNp_N PF10423.9 AMD22382.1 - 0.067 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus SLM4 PF16818.5 AMD22383.1 - 1.2e-57 194.3 0.0 1.4e-57 194.2 0.0 1.0 1 0 0 1 1 1 1 Protein SLM4 Dfp1_Him1_M PF08630.10 AMD22384.1 - 1.3e-41 141.8 0.0 4.8e-41 139.9 0.0 2.1 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.12 AMD22384.1 - 5.9e-20 71.1 1.1 1.3e-19 70.0 1.1 1.6 1 0 0 1 1 1 1 DBF zinc finger Zn_clus PF00172.18 AMD22385.1 - 7.3e-08 32.4 10.0 7.3e-08 32.4 10.0 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 AMD22386.1 - 2.7e-11 43.3 7.8 6e-06 26.4 0.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD22386.1 - 6.6e-08 32.6 2.7 7.2e-06 26.2 0.5 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD22386.1 - 3.9e-07 30.3 6.7 0.0022 18.7 0.1 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 AMD22386.1 - 0.0052 17.0 0.7 0.019 15.2 0.6 2.0 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 AMD22386.1 - 0.0058 16.6 0.9 0.089 12.8 0.0 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 AMD22386.1 - 0.0068 16.3 0.8 0.021 14.7 0.8 1.9 1 1 0 1 1 1 1 SprT-like zinc ribbon domain zf-C2H2_jaz PF12171.8 AMD22386.1 - 0.021 15.1 0.0 0.13 12.6 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AMD22386.1 - 0.092 13.2 2.1 2.8 8.5 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type CpXC PF14353.6 AMD22386.1 - 0.37 10.8 2.5 3.3 7.8 0.1 2.6 2 1 1 3 3 3 0 CpXC protein ADK_lid PF05191.14 AMD22386.1 - 0.62 10.1 3.0 6.4 6.8 0.4 2.5 2 0 0 2 2 2 0 Adenylate kinase, active site lid Peptidase_M28 PF04389.17 AMD22387.1 - 2.3e-38 131.9 0.0 6.4e-38 130.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 AMD22387.1 - 1.2e-05 25.1 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 AMD22387.1 - 0.0015 17.6 0.0 0.0031 16.6 0.0 1.4 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase URO-D PF01208.17 AMD22388.1 - 1.3e-125 419.1 0.0 1.5e-125 419.0 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) PP1 PF07430.11 AMD22388.1 - 0.18 11.9 0.1 5.3 7.2 0.0 2.4 2 0 0 2 2 2 0 Phloem filament protein PP1 cystatin-like domain bVLRF1 PF18826.1 AMD22389.1 - 2.2e-58 196.4 2.0 9.9e-58 194.2 0.6 2.3 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 AMD22389.1 - 1.2e-05 25.4 0.0 2.6e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 AMD22389.1 - 0.05 14.2 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) CTU2 PF10288.9 AMD22389.1 - 0.23 11.7 4.0 0.13 12.5 0.3 2.7 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Mst1_SARAH PF11629.8 AMD22389.1 - 1.4 9.0 6.2 20 5.4 0.1 3.1 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 SNF2_N PF00176.23 AMD22390.1 - 8.9e-60 202.2 0.0 1.4e-59 201.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD22390.1 - 3.5e-14 53.1 0.0 1.4e-13 51.2 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD22390.1 - 5.2e-12 46.1 0.0 1.4e-11 44.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AMD22390.1 - 4.7e-08 32.6 0.6 3.7e-07 29.6 0.6 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 AMD22390.1 - 5.2e-05 23.1 0.0 0.00012 21.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2439 PF10382.9 AMD22390.1 - 0.0076 16.6 0.1 0.025 14.9 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) ERCC3_RAD25_C PF16203.5 AMD22390.1 - 0.035 13.3 0.1 0.062 12.5 0.1 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase COX7a PF02238.15 AMD22394.1 - 7.7e-20 71.0 0.5 8.4e-20 70.9 0.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII CCER1 PF15482.6 AMD22394.1 - 0.084 12.8 0.1 0.084 12.8 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 zf-C3HC4_4 PF15227.6 AMD22395.1 - 4.1e-10 39.6 10.9 4.1e-10 39.6 10.9 2.4 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 AMD22395.1 - 3.8e-09 36.3 9.2 3.8e-09 36.3 9.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD22395.1 - 9.2e-09 35.0 7.5 9.2e-09 35.0 7.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AMD22395.1 - 2.1e-07 30.7 6.6 2.1e-07 30.7 6.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD22395.1 - 3e-07 30.4 4.6 3e-07 30.4 4.6 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 AMD22395.1 - 4.9e-07 30.0 8.0 4.9e-07 30.0 8.0 2.4 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 AMD22395.1 - 3.5e-05 24.0 4.8 3.5e-05 24.0 4.8 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AMD22395.1 - 0.00018 21.5 2.5 0.00018 21.5 2.5 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 AMD22395.1 - 0.00021 21.2 7.2 0.00021 21.2 7.2 2.7 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 AMD22395.1 - 0.00039 20.2 5.3 0.00039 20.2 5.3 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 AMD22395.1 - 0.017 15.0 7.8 0.026 14.4 1.7 2.3 2 0 0 2 2 2 0 zf-RING of BARD1-type protein PolC_DP2 PF03833.13 AMD22395.1 - 0.023 12.6 5.3 0.38 8.5 1.7 2.1 2 0 0 2 2 2 0 DNA polymerase II large subunit DP2 DZR PF12773.7 AMD22395.1 - 0.054 13.5 11.7 1.3 9.1 0.6 2.8 2 1 0 2 2 2 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 AMD22395.1 - 0.15 12.0 3.4 53 3.8 0.0 3.6 3 0 0 3 3 3 0 zinc-ribbon domain Zn_ribbon_recom PF13408.6 AMD22395.1 - 0.35 11.4 9.9 5.1 7.7 3.8 3.2 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Ogr_Delta PF04606.12 AMD22395.1 - 0.8 9.7 8.0 0.54 10.3 0.1 3.3 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger RecR PF02132.15 AMD22395.1 - 1.2 8.7 9.5 0.38 10.4 0.8 3.2 3 0 0 3 3 3 0 RecR protein HscB_4_cys PF18256.1 AMD22395.1 - 3.2 7.6 5.7 2.1 8.2 0.6 2.6 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif LRR_2 PF07723.13 AMD22397.1 - 2.7 8.8 0.0 2.7 8.8 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich Repeat DUF2428 PF10350.9 AMD22398.1 - 3.5e-50 170.8 0.2 7e-50 169.8 0.2 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 AMD22398.1 - 0.00034 20.6 0.6 0.57 10.6 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat Mg_trans_NIPA PF05653.14 AMD22399.1 - 1.6e-100 336.1 18.1 1.9e-100 335.8 18.1 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 AMD22399.1 - 9.8e-06 25.8 7.6 9.8e-06 25.8 7.6 3.5 3 1 0 3 3 3 2 EamA-like transporter family eIF-1a PF01176.19 AMD22400.1 - 8.2e-21 73.6 0.1 1.2e-20 73.1 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Glyco_transf_20 PF00982.21 AMD22401.1 - 2.1e-160 534.5 0.6 5.4e-160 533.2 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 AMD22401.1 - 2.2e-30 105.5 0.0 4.8e-30 104.4 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase HEPN_Swt1 PF18731.1 AMD22401.1 - 0.032 14.6 0.4 0.11 12.9 0.4 1.8 1 0 0 1 1 1 0 Swt1-like HEPN TatD_DNase PF01026.21 AMD22402.1 - 3.1e-34 118.5 0.0 3.9e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase SAP30_Sin3_bdg PF13867.6 AMD22403.1 - 2.3e-10 40.6 0.3 1e-06 29.0 0.0 2.4 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 Cue1_U7BR PF18499.1 AMD22404.1 - 2e-23 82.1 3.2 3.2e-23 81.5 3.2 1.3 1 0 0 1 1 1 1 Ubc7p-binding region of Cue1 CUE PF02845.16 AMD22404.1 - 8.1e-09 35.0 0.1 2.1e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 CUE domain ORC6 PF05460.13 AMD22404.1 - 0.0075 15.6 2.5 0.0088 15.4 2.5 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) MMM1 PF10296.9 AMD22404.1 - 0.011 14.8 0.1 0.02 14.0 0.1 1.4 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 MAM1 PF10434.9 AMD22404.1 - 0.016 14.8 0.1 0.022 14.4 0.1 1.3 1 1 0 1 1 1 0 Monopolin complex protein MAM1 Kei1 PF08552.11 AMD22404.1 - 0.11 12.3 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2232 PF09991.9 AMD22404.1 - 0.12 11.5 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) WD40 PF00400.32 AMD22405.1 - 1.5e-20 73.1 4.8 1.1e-05 26.0 0.0 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22405.1 - 4.4e-12 46.1 0.1 2.3e-05 24.6 0.0 4.7 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AMD22405.1 - 2.3e-06 27.6 0.3 0.0007 19.5 0.0 3.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 AMD22405.1 - 0.00034 19.8 0.7 0.39 9.7 0.2 2.5 2 1 0 2 2 2 2 Coatomer WD associated region BBS2_Mid PF14783.6 AMD22405.1 - 0.0099 15.9 0.3 12 6.0 0.0 3.4 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region HPS3_N PF14761.6 AMD22405.1 - 0.011 15.2 0.0 0.12 12.0 0.0 2.6 3 0 0 3 3 3 0 Hermansky-Pudlak syndrome 3 Ge1_WD40 PF16529.5 AMD22405.1 - 0.02 13.9 0.0 0.98 8.3 0.0 2.6 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AMD22405.1 - 0.029 13.7 2.0 0.062 12.6 0.1 2.3 3 0 0 3 3 3 0 WD40-like domain DPPIV_N PF00930.21 AMD22405.1 - 0.085 11.6 0.2 1.7 7.3 0.1 2.9 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region HIRA_B PF09453.10 AMD22405.1 - 0.14 12.1 0.4 0.32 10.9 0.4 1.6 1 0 0 1 1 1 0 HIRA B motif HAD_SAK_1 PF10307.9 AMD22406.1 - 2.4e-60 203.9 0.0 3.3e-60 203.4 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins RSN1_7TM PF02714.15 AMD22407.1 - 2e-78 263.4 23.2 5.1e-78 262.1 23.2 1.7 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AMD22407.1 - 6.3e-33 113.8 1.4 6.3e-33 113.8 1.4 3.1 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AMD22407.1 - 1.9e-30 106.4 1.0 3e-30 105.7 1.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 AMD22407.1 - 9e-26 89.9 0.0 2.6e-25 88.4 0.0 1.8 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter Pyrophosphatase PF00719.19 AMD22408.1 - 3.4e-53 179.7 0.0 4.3e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Nup188 PF10487.9 AMD22409.1 - 1.2e-275 917.1 31.4 1.2e-275 917.1 31.4 1.5 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 AMD22409.1 - 9.2e-23 80.7 9.3 2e-22 79.6 9.3 1.6 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain RRM_1 PF00076.22 AMD22410.1 - 7.5e-36 121.8 1.0 1.7e-11 43.8 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AMD22410.1 - 9e-32 108.8 1.0 1e-26 92.6 0.6 3.6 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_5 PF13893.6 AMD22410.1 - 0.0022 17.6 5.6 0.49 10.0 0.1 4.1 1 1 1 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lsm_interact PF05391.11 AMD22410.1 - 0.0029 17.0 1.8 0.0096 15.4 1.8 1.9 1 0 0 1 1 1 1 Lsm interaction motif PHM7_cyt PF14703.6 AMD22410.1 - 0.0078 16.5 0.1 0.13 12.4 0.0 2.8 3 0 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM PF05172.13 AMD22410.1 - 0.012 15.6 0.7 0.17 11.9 0.0 3.2 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif SpoVT_C PF15714.5 AMD22410.1 - 0.034 14.2 0.2 0.096 12.7 0.2 1.7 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor Nup35_RRM_2 PF14605.6 AMD22410.1 - 0.041 13.9 0.0 5.3 7.1 0.0 2.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif G-patch PF01585.23 AMD22411.1 - 0.013 15.3 2.4 0.21 11.5 2.4 2.4 1 1 0 1 1 1 0 G-patch domain DUF3807 PF12720.7 AMD22411.1 - 0.52 10.6 16.0 0.92 9.8 16.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 AMD22411.1 - 1.1 7.9 5.7 1.1 7.9 5.7 1.1 1 0 0 1 1 1 0 Presenilin RNA_polI_A34 PF08208.11 AMD22411.1 - 2.5 8.1 27.5 4.6 7.3 27.5 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Ureide_permease PF07168.11 AMD22411.1 - 3 6.5 3.9 3.5 6.3 3.9 1.1 1 0 0 1 1 1 0 Ureide permease Zip PF02535.22 AMD22411.1 - 4.6 6.4 10.0 6.1 6.0 10.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SR-25 PF10500.9 AMD22411.1 - 8.8 5.9 28.3 21 4.7 28.3 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PXA PF02194.15 AMD22412.1 - 3.5e-35 121.6 2.0 3.5e-35 121.6 2.0 2.6 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 AMD22412.1 - 4.3e-21 75.6 2.2 6.5e-21 75.0 0.1 2.5 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 AMD22412.1 - 2.7e-16 59.5 6.6 2.4e-15 56.5 2.5 3.2 2 1 0 2 2 2 1 PX domain RGS PF00615.19 AMD22412.1 - 4.9e-06 26.8 1.3 2.4e-05 24.6 1.3 2.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain ASFV_360 PF01671.16 AMD22412.1 - 0.014 14.9 0.5 0.014 14.9 0.5 1.8 2 0 0 2 2 2 0 African swine fever virus multigene family 360 protein Pox_Ag35 PF03286.14 AMD22412.1 - 0.36 10.6 3.2 0.99 9.2 3.2 1.7 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FapA PF03961.13 AMD22412.1 - 1.9 7.0 9.1 0.66 8.5 5.1 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A RRN9 PF10680.9 AMD22413.1 - 9.8e-15 54.6 0.4 2.1e-14 53.5 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor SRP19 PF01922.17 AMD22414.1 - 6.2e-32 110.4 0.0 1.2e-31 109.5 0.0 1.5 1 0 0 1 1 1 1 SRP19 protein Pribosyltran PF00156.27 AMD22415.1 - 7.2e-15 54.8 0.5 1.3e-14 54.0 0.5 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain zf-C3HC PF07967.13 AMD22416.1 - 1.1e-11 44.9 0.7 6.5e-10 39.2 0.2 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 AMD22416.1 - 0.002 18.3 6.6 0.0021 18.1 0.5 2.5 2 1 0 2 2 2 1 Rsm1-like SUN PF03856.13 AMD22417.1 - 2.9e-84 282.3 11.8 3.4e-84 282.1 11.8 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Glucosamine_iso PF01182.20 AMD22418.1 - 2.2e-59 201.1 0.0 2.5e-59 200.9 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HSF_DNA-bind PF00447.17 AMD22419.1 - 5.7e-23 81.3 0.2 4.7e-22 78.4 0.1 2.2 2 0 0 2 2 2 1 HSF-type DNA-binding Peptidase_C5 PF00770.18 AMD22419.1 - 0.074 12.7 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Adenovirus endoprotease RRM_1 PF00076.22 AMD22420.1 - 5.3e-33 112.7 0.1 1.3e-15 57.0 0.0 5.7 5 1 1 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 AMD22420.1 - 0.065 13.3 0.0 1.3 9.1 0.0 2.8 3 0 0 3 3 3 0 RNA binding domain RRM_7 PF16367.5 AMD22420.1 - 0.17 12.0 0.2 14 5.9 0.0 3.5 3 1 0 3 3 3 0 RNA recognition motif Dna2 PF08696.11 AMD22421.1 - 2.2e-55 187.6 0.6 2.2e-55 187.6 0.6 2.0 2 0 0 2 2 2 1 DNA replication factor Dna2 AAA_12 PF13087.6 AMD22421.1 - 8e-47 159.4 0.0 1.6e-46 158.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AMD22421.1 - 3e-29 102.6 0.1 1.1e-15 58.2 0.0 2.8 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 AMD22421.1 - 1.3e-14 54.3 0.0 2.8e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD22421.1 - 3.9e-10 40.3 0.1 1.2e-09 38.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain PDDEXK_1 PF12705.7 AMD22421.1 - 7.4e-07 29.3 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.18 AMD22421.1 - 1.7e-05 24.7 0.6 0.48 10.1 0.1 3.5 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 AMD22421.1 - 9.2e-05 22.6 0.2 0.00067 19.8 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function DUF83 AAA_33 PF13671.6 AMD22421.1 - 0.00082 19.5 0.1 0.016 15.4 0.0 2.7 3 0 0 3 3 2 1 AAA domain SRP54 PF00448.22 AMD22421.1 - 0.0019 17.9 0.2 0.0041 16.8 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 AMD22421.1 - 0.0028 18.1 0.0 0.009 16.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain UvrD-helicase PF00580.21 AMD22421.1 - 0.0043 16.6 0.0 0.013 15.0 0.0 1.8 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 AMD22421.1 - 0.0044 17.0 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 AMD22421.1 - 0.0044 16.9 0.0 0.015 15.2 0.0 1.9 1 0 0 1 1 1 1 Helicase AAA_7 PF12775.7 AMD22421.1 - 0.0054 16.3 0.1 0.015 14.9 0.1 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region NTPase_1 PF03266.15 AMD22421.1 - 0.0054 16.6 0.1 0.065 13.2 0.4 2.4 2 0 0 2 2 2 1 NTPase PhoH PF02562.16 AMD22421.1 - 0.0056 16.2 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 AMD22421.1 - 0.011 15.0 0.0 0.024 13.9 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 AMD22421.1 - 0.013 14.7 0.0 0.097 11.8 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase AAA_5 PF07728.14 AMD22421.1 - 0.016 15.2 0.1 0.045 13.8 0.1 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MobB PF03205.14 AMD22421.1 - 0.034 14.0 0.2 0.086 12.7 0.2 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.29 AMD22421.1 - 0.034 14.6 0.1 0.096 13.1 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 AMD22421.1 - 0.038 14.1 0.8 0.14 12.2 0.8 1.9 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 AMD22421.1 - 0.074 12.8 0.6 0.21 11.4 0.2 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 AMD22421.1 - 0.078 12.2 0.1 0.17 11.0 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain HTH_54 PF18607.1 AMD22421.1 - 0.08 13.0 0.0 0.31 11.1 0.0 2.0 2 0 0 2 2 1 0 ParA helix turn helix domain DnaB_C PF03796.15 AMD22421.1 - 0.1 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain SH3_2 PF07653.17 AMD22421.1 - 0.1 12.3 0.0 0.45 10.2 0.0 2.0 2 0 0 2 2 2 0 Variant SH3 domain MeaB PF03308.16 AMD22421.1 - 0.16 11.0 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PalH PF08733.10 AMD22422.1 - 7.8e-54 182.9 20.5 1.6e-53 181.8 20.8 1.4 2 0 0 2 2 2 1 PalH/RIM21 Cellulase PF00150.18 AMD22423.1 - 2.5e-11 43.6 7.3 4.3e-10 39.5 7.3 2.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) EamA PF00892.20 AMD22425.1 - 1.7e-07 31.5 33.0 0.00014 22.0 10.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family Nse5 PF08691.10 AMD22426.1 - 2.2e-24 86.0 7.8 3e-24 85.6 7.8 1.1 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Hydrolase PF00702.26 AMD22427.1 - 2.1e-07 31.4 0.0 3.1e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AMD22427.1 - 1.8e-06 28.1 0.0 3e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase NifW PF03206.14 AMD22428.1 - 0.022 15.3 0.0 12 6.5 0.0 2.6 2 0 0 2 2 2 0 Nitrogen fixation protein NifW ABC_tran PF00005.27 AMD22429.1 - 3e-48 163.8 0.0 3.4e-23 82.7 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 AMD22429.1 - 3.8e-22 78.1 1.5 3.8e-22 78.1 1.5 3.4 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 AMD22429.1 - 1.5e-20 74.2 0.4 5e-06 26.5 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AMD22429.1 - 1.4e-09 37.7 1.4 0.76 9.2 0.0 4.9 3 1 1 5 5 5 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AMD22429.1 - 1.4e-07 31.2 0.0 0.0095 15.7 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 AMD22429.1 - 6.5e-07 29.7 0.0 0.052 13.8 0.0 3.0 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 AMD22429.1 - 4.6e-06 26.7 0.0 0.0086 16.2 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD22429.1 - 6.1e-06 26.2 5.1 0.00074 19.5 0.1 3.4 4 0 0 4 4 3 1 RsgA GTPase AAA_18 PF13238.6 AMD22429.1 - 7.3e-06 26.6 0.3 0.044 14.3 0.0 3.4 4 1 0 4 4 2 2 AAA domain AAA PF00004.29 AMD22429.1 - 8.5e-06 26.2 0.1 0.15 12.5 0.0 3.7 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AMD22429.1 - 2.4e-05 24.8 0.0 0.036 14.4 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 AMD22429.1 - 2.8e-05 24.1 0.6 0.19 11.6 0.0 3.0 3 0 0 3 3 3 2 NACHT domain AAA_33 PF13671.6 AMD22429.1 - 3.8e-05 23.9 1.1 0.049 13.8 0.1 3.4 4 0 0 4 4 3 1 AAA domain RNA_helicase PF00910.22 AMD22429.1 - 5.2e-05 23.6 0.0 0.35 11.3 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 AMD22429.1 - 7.1e-05 23.1 0.2 0.53 10.5 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 AMD22429.1 - 8.5e-05 23.1 0.3 0.017 15.6 0.0 4.2 4 1 0 5 5 3 2 AAA domain AAA_14 PF13173.6 AMD22429.1 - 0.00018 21.6 0.1 1.1 9.3 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_24 PF13479.6 AMD22429.1 - 0.00031 20.5 0.4 0.38 10.5 0.1 3.2 3 0 0 3 3 3 1 AAA domain MCM PF00493.23 AMD22429.1 - 0.00032 19.9 0.1 0.1 11.7 0.0 2.5 2 0 0 2 2 2 1 MCM P-loop domain NB-ARC PF00931.22 AMD22429.1 - 0.0013 18.0 0.0 1.1 8.4 0.0 3.3 3 0 0 3 3 3 1 NB-ARC domain AAA_15 PF13175.6 AMD22429.1 - 0.0013 18.5 15.1 0.07 12.8 0.8 3.8 2 1 1 3 3 3 2 AAA ATPase domain Rad17 PF03215.15 AMD22429.1 - 0.0017 18.3 0.0 1.1 9.1 0.0 2.6 3 0 0 3 3 2 1 Rad17 P-loop domain MeaB PF03308.16 AMD22429.1 - 0.0019 17.2 0.5 0.12 11.3 0.1 2.6 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 AMD22429.1 - 0.0042 17.1 0.2 1.4 8.9 0.0 3.0 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 AMD22429.1 - 0.0055 16.7 0.0 3.3 7.7 0.1 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Roc PF08477.13 AMD22429.1 - 0.0056 16.9 0.4 1.7 8.9 0.0 3.0 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 AMD22429.1 - 0.0061 16.3 0.0 0.11 12.2 0.0 2.7 3 0 0 3 3 3 1 IstB-like ATP binding protein NTPase_1 PF03266.15 AMD22429.1 - 0.0069 16.3 0.3 0.39 10.6 0.2 2.7 2 0 0 2 2 2 1 NTPase DUF815 PF05673.13 AMD22429.1 - 0.0082 15.3 0.4 3 6.9 0.1 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF815) VirE PF05272.11 AMD22429.1 - 0.011 15.5 0.1 1.3 8.8 0.0 3.0 3 0 0 3 3 3 0 Virulence-associated protein E G-alpha PF00503.20 AMD22429.1 - 0.017 14.3 0.9 1.2 8.2 0.1 2.8 2 2 1 3 3 3 0 G-protein alpha subunit MobB PF03205.14 AMD22429.1 - 0.025 14.5 0.5 0.21 11.5 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_7 PF12775.7 AMD22429.1 - 0.026 14.1 0.1 2.1 7.8 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_25 PF13481.6 AMD22429.1 - 0.046 13.3 2.3 0.99 8.9 0.1 3.6 4 1 0 4 4 2 0 AAA domain PduV-EutP PF10662.9 AMD22429.1 - 0.072 12.8 0.1 18 5.1 0.1 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 AMD22429.1 - 0.072 12.8 4.5 0.32 10.7 0.3 3.2 3 1 0 3 3 3 0 AAA domain FeoB_N PF02421.18 AMD22429.1 - 0.075 12.6 0.0 2.2 7.8 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B CLP1_P PF16575.5 AMD22429.1 - 0.1 12.4 0.9 3.8 7.3 0.1 3.2 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Dynamin_N PF00350.23 AMD22429.1 - 0.11 12.5 7.3 2.8 8.0 0.0 4.1 3 1 0 4 4 4 0 Dynamin family ATPase_2 PF01637.18 AMD22429.1 - 0.15 12.0 5.4 5.3 6.9 0.0 3.6 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 AMD22429.1 - 0.16 11.7 0.4 32 4.2 0.2 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_27 PF13514.6 AMD22429.1 - 0.44 10.1 6.5 1.3 8.6 0.0 3.0 4 0 0 4 4 2 0 AAA domain AAA_17 PF13207.6 AMD22429.1 - 0.72 10.3 4.8 37 4.7 0.0 3.8 4 0 0 4 4 4 0 AAA domain SRP54 PF00448.22 AMD22429.1 - 5 6.7 7.7 4.1 7.0 0.0 3.6 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain DUF87 PF01935.17 AMD22429.1 - 7.7 6.5 12.1 12 5.9 0.1 3.9 4 1 1 5 5 4 0 Helicase HerA, central domain PNRC PF15365.6 AMD22430.1 - 0.0012 18.6 1.1 0.0012 18.6 1.1 2.7 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif DUF908 PF06012.12 AMD22430.1 - 1.7 8.0 4.8 0.81 9.0 2.7 1.4 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) DUF5364 PF17322.2 AMD22431.1 - 4.5e-41 141.2 3.4 5e-41 141.0 3.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5364) NIF3 PF01784.18 AMD22432.1 - 6.5e-66 222.4 0.0 7.9e-66 222.2 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.18 AMD22433.1 - 2e-15 56.8 0.0 2.3e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein Kinesin PF00225.23 AMD22435.1 - 7.8e-113 376.8 0.1 1.2e-112 376.2 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AMD22435.1 - 9.9e-25 87.2 0.0 2.9e-24 85.7 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding Borrelia_REV PF03978.13 AMD22435.1 - 0.015 15.3 1.1 0.048 13.6 1.1 1.9 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein AAA_24 PF13479.6 AMD22435.1 - 0.57 9.9 5.1 16 5.2 0.6 3.3 2 1 1 3 3 3 0 AAA domain Cyclin_N PF00134.23 AMD22436.1 - 0.00075 19.2 0.0 0.0013 18.4 0.0 1.4 1 1 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AMD22436.1 - 0.0035 17.7 0.1 0.0066 16.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin ANAPC4_WD40 PF12894.7 AMD22437.1 - 4e-09 36.6 0.0 0.00052 20.3 0.0 2.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD22437.1 - 4.5e-09 36.8 19.9 0.00016 22.4 0.1 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat Rhamnogal_lyase PF06045.11 AMD22437.1 - 0.0091 15.4 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Rhamnogalacturonate lyase family PX PF00787.24 AMD22438.1 - 5.1e-14 52.2 1.7 1.2e-13 51.0 0.3 2.1 2 1 0 2 2 2 1 PX domain DUF2312 PF10073.9 AMD22438.1 - 0.11 12.2 1.2 0.34 10.6 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF16 PF01519.16 AMD22438.1 - 9.8 6.7 9.6 2 8.9 2.0 2.8 3 0 0 3 3 3 0 Protein of unknown function DUF16 ATP_bind_3 PF01171.20 AMD22439.1 - 1.3e-17 64.1 0.0 2.3e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 AMD22439.1 - 4.2e-17 61.3 5.1 4.2e-17 61.3 5.1 3.3 3 0 0 3 3 3 1 Zinc-ribbon tRNA_Me_trans PF03054.16 AMD22439.1 - 0.0094 14.8 0.0 0.016 14.0 0.0 1.4 1 1 0 1 1 1 1 tRNA methyl transferase TF_Zn_Ribbon PF08271.12 AMD22439.1 - 2.5 7.7 8.9 3.6 7.2 0.2 3.3 3 0 0 3 3 3 0 TFIIB zinc-binding Ras PF00071.22 AMD22442.1 - 2e-60 203.0 0.5 2.5e-60 202.8 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22442.1 - 1.5e-34 118.8 0.1 2.5e-34 118.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD22442.1 - 5.7e-14 51.9 0.0 7.9e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD22442.1 - 6e-07 29.6 0.2 1.6e-06 28.2 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD22442.1 - 3.5e-05 23.8 0.3 0.0057 16.6 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 AMD22442.1 - 0.00018 20.9 0.1 0.00023 20.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AMD22442.1 - 0.00032 20.3 0.1 0.0013 18.3 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 AMD22442.1 - 0.008 15.9 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 AMD22442.1 - 0.013 16.0 0.5 0.21 12.1 0.1 2.5 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 AMD22442.1 - 0.017 15.4 0.0 0.079 13.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AMD22442.1 - 0.018 15.4 0.1 0.033 14.6 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 AMD22442.1 - 0.023 14.5 0.1 0.028 14.2 0.1 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system FeoB_N PF02421.18 AMD22442.1 - 0.026 14.1 0.0 0.054 13.0 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B SRPRB PF09439.10 AMD22442.1 - 0.033 13.6 0.1 0.088 12.2 0.0 1.7 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 AMD22442.1 - 0.06 13.6 0.1 0.33 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AMD22442.1 - 0.068 12.9 0.1 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 AMD22442.1 - 0.068 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain ABC_tran PF00005.27 AMD22442.1 - 0.081 13.4 1.6 0.22 12.0 1.6 1.9 1 1 0 1 1 1 0 ABC transporter NDT80_PhoG PF05224.12 AMD22442.1 - 0.087 13.0 0.0 0.091 13.0 0.0 1.2 1 0 0 1 1 1 0 NDT80 / PhoG like DNA-binding family AAA_5 PF07728.14 AMD22442.1 - 0.11 12.4 0.0 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CHZ PF09649.10 AMD22443.1 - 1.4e-17 62.8 3.4 1.4e-17 62.8 3.4 2.6 3 1 0 3 3 3 1 Histone chaperone domain CHZ Prothymosin PF03247.14 AMD22443.1 - 5.3 7.5 44.0 3 8.3 11.1 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family LSM PF01423.22 AMD22444.1 - 1.2e-17 63.4 0.0 2.2e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 LSM domain CDK5_activator PF03261.15 AMD22444.1 - 0.027 14.0 8.8 0.033 13.8 8.8 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Nucleo_P87 PF07267.11 AMD22444.1 - 0.027 13.3 8.7 0.03 13.2 8.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TFIIA PF03153.13 AMD22444.1 - 0.029 14.4 30.2 0.034 14.2 30.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zip PF02535.22 AMD22444.1 - 0.14 11.3 6.5 0.18 11.0 6.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PA26 PF04636.13 AMD22444.1 - 0.14 11.0 7.4 0.18 10.7 7.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Suf PF05843.14 AMD22444.1 - 0.22 11.4 17.6 0.27 11.2 17.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FAM60A PF15396.6 AMD22444.1 - 0.31 11.0 10.9 0.38 10.7 10.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 AMD22444.1 - 0.5 9.3 10.3 0.58 9.1 10.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 eIF-3_zeta PF05091.12 AMD22444.1 - 0.67 8.9 14.3 0.94 8.4 14.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4407 PF14362.6 AMD22444.1 - 0.71 9.2 10.5 0.77 9.1 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SMYLE_N PF18615.1 AMD22444.1 - 0.83 9.1 10.8 1.2 8.7 10.8 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain GREB1 PF15782.5 AMD22444.1 - 0.89 6.6 12.8 0.95 6.5 12.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ureide_permease PF07168.11 AMD22444.1 - 0.98 8.1 3.0 1.4 7.6 3.0 1.3 1 0 0 1 1 1 0 Ureide permease XRN_M PF17846.1 AMD22444.1 - 1 8.2 7.9 1.1 8.2 7.9 1.2 1 0 0 1 1 1 0 Xrn1 helical domain DDHD PF02862.17 AMD22444.1 - 1.2 9.2 10.3 1.6 8.8 10.3 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 AMD22444.1 - 2 8.1 13.0 2.7 7.8 13.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Med3 PF11593.8 AMD22444.1 - 7.4 5.7 25.4 10 5.2 25.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Hid1 PF12722.7 AMD22444.1 - 8.8 4.3 14.5 10 4.1 14.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NPR3 PF03666.13 AMD22444.1 - 9.4 4.9 15.7 13 4.4 15.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C2H2 PF00096.26 AMD22445.1 - 1.7e-06 28.2 23.8 2.3e-05 24.6 3.1 3.0 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD22445.1 - 3.6e-06 27.1 24.3 7.9e-05 22.9 5.7 3.5 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD22445.1 - 1.8e-05 25.1 14.1 0.00095 19.8 2.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AMD22445.1 - 0.011 16.0 9.7 0.18 12.1 2.8 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AMD22445.1 - 0.049 13.6 1.7 0.049 13.6 1.7 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HE PF16278.5 AMD22445.1 - 0.12 12.8 9.5 0.46 11.0 2.0 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 AMD22445.1 - 0.13 12.0 0.4 0.13 12.0 0.4 3.6 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 AMD22445.1 - 0.28 11.5 5.0 1.6 9.1 1.5 2.2 1 1 1 2 2 2 0 C2H2-type zinc ribbon AMPK1_CBM PF16561.5 AMD22446.1 - 4e-30 103.9 0.0 7.7e-30 103.0 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 AMD22446.1 - 6.3e-27 93.6 2.3 1.4e-26 92.6 2.3 1.6 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM53 PF16760.5 AMD22446.1 - 0.15 12.7 0.0 0.72 10.5 0.0 2.1 2 0 0 2 2 2 0 Starch/carbohydrate-binding module (family 53) SPT16 PF08644.11 AMD22447.1 - 5.8e-51 172.6 0.1 5.8e-51 172.6 0.1 1.9 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 AMD22447.1 - 2.4e-49 167.2 2.4 8.4e-49 165.5 0.1 2.7 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 AMD22447.1 - 6.9e-32 110.8 0.0 1.2e-31 110.1 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 AMD22447.1 - 3.1e-13 49.9 0.3 1.3e-12 48.0 0.2 2.1 2 0 0 2 2 2 1 Histone chaperone Rttp106-like DUF749 PF05370.11 AMD22447.1 - 0.031 14.4 0.2 0.091 12.9 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF749) Clathrin PF00637.20 AMD22448.1 - 2.2e-188 617.7 47.3 7.4e-32 110.2 0.9 8.7 9 0 0 9 9 9 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 AMD22448.1 - 5.6e-25 87.0 0.1 5.6e-25 87.0 0.1 3.1 4 0 0 4 4 4 1 Clathrin-H-link Clathrin_propel PF01394.20 AMD22448.1 - 8.2e-19 66.9 6.3 0.00038 20.6 0.6 5.9 5 0 0 5 5 5 5 Clathrin propeller repeat Clathrin-link PF09268.10 AMD22448.1 - 2.1e-06 26.9 0.1 2.1e-06 26.9 0.1 2.7 3 0 0 3 3 3 1 Clathrin, heavy-chain linker TPR_8 PF13181.6 AMD22448.1 - 9e-05 22.4 8.5 2 8.8 0.1 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 AMD22448.1 - 0.00014 21.1 14.0 0.11 11.5 0.1 6.4 6 1 1 7 7 7 2 Coatomer WD associated region RcbX PF02341.15 AMD22448.1 - 0.0074 16.5 0.0 4 7.7 0.0 2.7 2 0 0 2 2 2 1 RbcX protein TPR_1 PF00515.28 AMD22448.1 - 0.0075 16.0 11.4 0.23 11.3 0.0 6.3 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 AMD22448.1 - 0.015 15.8 4.2 6.4 7.4 0.0 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat Vps39_1 PF10366.9 AMD22448.1 - 0.018 15.4 13.9 2.1 8.7 0.1 6.7 7 0 0 7 7 6 0 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 AMD22448.1 - 0.021 14.9 8.8 3.4 8.0 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 AMD22448.1 - 0.054 13.8 9.0 7.5 6.9 0.1 6.6 6 2 1 7 7 7 0 Tetratricopeptide repeat Rop PF01815.16 AMD22448.1 - 0.086 12.7 0.0 0.38 10.7 0.0 2.1 1 0 0 1 1 1 0 Rop protein TPR_17 PF13431.6 AMD22448.1 - 0.83 10.2 3.2 53 4.5 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ACOX PF01756.19 AMD22449.1 - 2.6e-41 141.2 0.2 5.5e-41 140.1 0.1 1.7 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 AMD22449.1 - 7.1e-20 71.0 0.5 1.6e-19 69.9 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 AMD22449.1 - 4.3e-07 30.5 0.0 8e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 AMD22449.1 - 2.3e-05 24.6 0.0 0.005 17.1 0.0 2.5 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain CDP-OH_P_transf PF01066.21 AMD22450.1 - 2e-11 44.5 0.8 5.4e-11 43.1 0.8 1.8 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase DUF2420 PF10336.9 AMD22451.1 - 1.3e-33 115.3 0.7 2.1e-33 114.6 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Gemini_AL1 PF00799.20 AMD22451.1 - 0.083 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain Ppx-GppA PF02541.16 AMD22452.1 - 4.9e-61 206.7 0.0 6.4e-61 206.3 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family CSN8_PSD8_EIF3K PF10075.9 AMD22453.1 - 5.9e-19 68.5 0.9 8.8e-19 67.9 0.9 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 AMD22453.1 - 2e-05 24.1 0.7 3e-05 23.6 0.7 1.2 1 0 0 1 1 1 1 SAC3/GANP family Hexokinase_2 PF03727.16 AMD22454.1 - 1e-78 264.1 0.0 1.9e-78 263.2 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 AMD22454.1 - 3.1e-71 239.4 0.0 4.2e-71 239.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.21 AMD22454.1 - 0.2 11.2 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Mannosidase_ig PF17786.1 AMD22455.1 - 3.8e-12 46.7 0.0 1e-11 45.2 0.0 1.8 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 AMD22455.1 - 1.4e-05 25.8 0.0 9.1e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 AMD22455.1 - 0.0045 16.9 0.2 0.02 14.8 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 AMD22455.1 - 0.0065 16.2 0.0 0.017 14.8 0.0 1.7 1 0 0 1 1 1 1 Ig-fold domain Asp PF00026.23 AMD22456.1 - 5.4e-75 252.7 0.4 7.8e-75 252.2 0.4 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD22456.1 - 6.9e-10 39.4 0.6 2.7e-09 37.5 0.6 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AMD22456.1 - 0.011 16.4 0.5 8.3 7.1 0.2 3.1 2 1 0 2 2 2 0 Aspartyl protease Asp PF00026.23 AMD22457.1 - 2.9e-77 260.2 0.5 3.4e-77 260.0 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AMD22457.1 - 1.7e-11 44.7 0.4 5e-11 43.2 0.4 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AMD22457.1 - 0.13 12.9 1.7 21 5.9 0.6 3.3 2 1 0 2 2 2 0 Aspartyl protease AA_permease_2 PF13520.6 AMD22458.1 - 1.3e-84 284.5 43.6 1.6e-84 284.2 43.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AMD22458.1 - 1e-17 63.9 42.4 1.8e-17 63.1 42.4 1.3 1 1 0 1 1 1 1 Amino acid permease Peptidase_M16 PF00675.20 AMD22459.1 - 3.8e-25 88.6 0.1 5.8e-25 88.0 0.1 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AMD22459.1 - 1e-06 28.9 0.1 3.2e-05 24.0 0.0 2.7 2 1 0 2 2 2 1 Peptidase M16 inactive domain RNA_pol_Rpc82 PF05645.13 AMD22460.1 - 4.6e-60 203.6 0.1 7.2e-60 202.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 AMD22460.1 - 6e-19 67.9 6.7 1.8e-18 66.4 0.4 3.5 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 AMD22460.1 - 2.1e-05 24.3 4.0 0.07 13.0 0.1 3.0 3 0 0 3 3 3 2 TFIIE alpha subunit DsrD PF08679.11 AMD22460.1 - 0.12 12.7 1.9 15 5.9 0.0 3.7 3 0 0 3 3 3 0 Dissimilatory sulfite reductase D (DsrD) TPR_22 PF18833.1 AMD22461.1 - 2.1e-38 130.3 2.3 2.5e-38 130.1 0.3 2.4 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 AMD22461.1 - 1.1e-26 90.8 12.1 0.00036 20.4 0.0 13.7 14 0 0 14 14 13 5 Tetratricopeptide repeat TPR_19 PF14559.6 AMD22461.1 - 2e-26 92.3 0.0 8.1e-06 26.3 0.0 9.4 8 2 2 10 10 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 AMD22461.1 - 1.4e-22 78.5 10.4 8.5e-05 22.2 0.0 11.9 12 1 0 12 12 11 3 Tetratricopeptide repeat TPR_11 PF13414.6 AMD22461.1 - 1.8e-20 72.4 7.3 0.0006 19.4 0.0 9.9 10 2 2 12 12 12 4 TPR repeat TPR_8 PF13181.6 AMD22461.1 - 4.4e-20 70.2 6.8 5.6e-06 26.2 0.0 11.4 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_16 PF13432.6 AMD22461.1 - 6e-20 71.6 0.1 0.00016 22.3 0.1 7.2 5 2 2 7 7 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 AMD22461.1 - 6.4e-16 57.7 0.3 0.29 12.1 0.0 11.3 9 2 4 13 13 11 3 Tetratricopeptide repeat TPR_12 PF13424.6 AMD22461.1 - 1.4e-14 54.2 6.1 0.13 12.6 0.0 8.9 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 AMD22461.1 - 7.9e-12 44.7 0.3 0.011 16.0 0.0 9.7 11 0 0 11 11 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD22461.1 - 7e-10 39.0 4.6 0.015 15.5 0.0 6.0 5 2 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 AMD22461.1 - 9.6e-10 38.5 0.2 7.2 7.5 0.0 9.9 11 0 0 11 11 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 AMD22461.1 - 2.7e-06 27.4 0.5 0.23 11.7 0.0 6.4 7 1 1 8 8 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 AMD22461.1 - 4.3e-06 26.4 2.5 0.43 10.7 0.0 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat Coatomer_E PF04733.14 AMD22461.1 - 7.3e-05 22.3 0.7 0.0017 17.9 0.0 2.6 2 0 0 2 2 2 1 Coatomer epsilon subunit TPR_10 PF13374.6 AMD22461.1 - 0.00035 20.4 0.0 69 3.5 0.1 6.8 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_20 PF14561.6 AMD22461.1 - 0.0033 17.7 5.7 5.7 7.3 0.0 6.4 7 1 1 8 8 6 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 AMD22461.1 - 0.0058 16.3 0.0 0.023 14.3 0.0 2.0 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB1_HrpK) Alkyl_sulf_dimr PF14863.6 AMD22461.1 - 0.015 15.7 2.5 9.9 6.6 0.0 4.3 5 0 0 5 5 3 0 Alkyl sulfatase dimerisation Fis1_TPR_C PF14853.6 AMD22461.1 - 0.025 14.6 0.0 0.33 11.1 0.0 2.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 AMD22461.1 - 0.05 14.2 0.0 1.3e+02 3.6 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3198 PF11433.8 AMD22461.1 - 0.13 12.2 0.0 0.5 10.3 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) MAS20 PF02064.15 AMD22461.1 - 0.17 12.0 0.4 1.9 8.6 0.0 2.9 3 0 0 3 3 2 0 MAS20 protein import receptor EF-hand_6 PF13405.6 AMD22462.1 - 4.2e-05 23.1 0.4 0.00028 20.6 0.2 2.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 AMD22462.1 - 5.9e-05 22.3 0.7 0.00027 20.3 0.2 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 AMD22462.1 - 0.0001 22.7 0.1 0.00022 21.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 AMD22462.1 - 0.042 13.3 1.1 0.14 11.7 1.1 1.9 1 0 0 1 1 1 0 EF hand RNA_pol_Rpb6 PF01192.22 AMD22463.1 - 8.5e-17 60.8 0.1 1.2e-16 60.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 zf-C2H2 PF00096.26 AMD22464.1 - 1.4e-33 113.4 68.2 0.00011 22.4 3.1 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22464.1 - 1.6e-21 75.1 63.9 0.00026 21.6 2.3 9.4 9 0 0 9 9 9 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AMD22464.1 - 2.9e-15 55.9 69.4 3.8e-05 23.9 2.0 10.1 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AMD22464.1 - 2.5e-06 27.6 40.4 0.022 15.1 0.6 8.1 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 AMD22464.1 - 0.00094 19.4 28.7 0.34 11.2 5.2 5.0 2 1 3 5 5 5 3 C2H2-type zinc ribbon zf-met PF12874.7 AMD22464.1 - 0.0023 18.3 42.7 0.1 13.0 1.8 8.6 10 0 0 10 10 10 4 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 AMD22464.1 - 0.0026 17.9 20.6 0.022 14.9 2.2 4.1 4 0 0 4 4 4 3 Zinc ribbon domain zf-LYAR PF08790.11 AMD22464.1 - 0.04 13.8 5.5 0.78 9.7 0.0 4.3 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-C2H2_aberr PF17017.5 AMD22464.1 - 0.21 11.7 0.1 0.21 11.7 0.1 4.8 2 1 4 6 6 6 0 Aberrant zinc-finger Trm112p PF03966.16 AMD22464.1 - 0.27 11.8 2.9 16 6.2 0.8 3.0 2 1 0 2 2 2 0 Trm112p-like protein HypA PF01155.19 AMD22464.1 - 0.9 9.6 16.2 1.6 8.8 0.6 3.7 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 AMD22464.1 - 1.7 9.4 16.8 0.82 10.5 0.3 3.8 2 1 1 3 3 3 0 zinc-ribbon family zf_ZIC PF18366.1 AMD22464.1 - 2.8 8.1 11.7 1.3 9.2 1.1 4.1 4 0 0 4 4 4 0 Zic proteins zinc finger domain FOXP-CC PF16159.5 AMD22464.1 - 6.5 7.5 29.0 0.21 12.3 0.9 6.3 4 1 2 6 6 6 0 FOXP coiled-coil domain G-alpha PF00503.20 AMD22465.1 - 1.7e-104 349.8 0.3 2.1e-104 349.5 0.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 AMD22465.1 - 1.6e-13 50.4 0.6 2.7e-09 36.7 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AMD22465.1 - 5e-05 22.8 0.6 0.003 16.9 0.0 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 AMD22465.1 - 0.0022 18.2 0.1 2.7 8.2 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 AMD22465.1 - 0.0032 17.3 0.1 0.0059 16.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AMD22465.1 - 0.046 13.4 1.0 0.071 12.8 1.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Lipase_3 PF01764.25 AMD22466.1 - 3.9e-37 127.3 0.0 2.3e-36 124.8 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 AMD22466.1 - 0.018 14.3 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AMD22466.1 - 0.034 14.7 0.0 0.04 14.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 AMD22466.1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Na_Ca_ex PF01699.24 AMD22467.1 - 3.3e-42 144.0 48.5 1.6e-24 86.6 16.1 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein PfkB PF00294.24 AMD22468.1 - 9.6e-70 235.3 0.4 1.2e-69 234.9 0.4 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 AMD22468.1 - 0.019 14.3 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase TRAM_LAG1_CLN8 PF03798.16 AMD22469.1 - 1.3e-26 93.6 18.3 2e-26 93.0 18.3 1.3 1 0 0 1 1 1 1 TLC domain DUF2645 PF10840.8 AMD22469.1 - 0.03 15.0 0.5 0.03 15.0 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2645) DUF4149 PF13664.6 AMD22469.1 - 2.4 8.5 7.4 0.25 11.7 2.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) Peptidase_M48_N PF16491.5 AMD22470.1 - 2.4e-53 180.7 10.4 2.4e-53 180.7 10.4 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 AMD22470.1 - 1.5e-43 148.9 0.0 2.2e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 DUF3390 PF11870.8 AMD22470.1 - 0.024 15.0 0.3 0.07 13.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) Peptidase_M56 PF05569.11 AMD22470.1 - 0.039 13.1 0.1 0.096 11.9 0.1 1.7 1 1 0 1 1 1 0 BlaR1 peptidase M56 DUF2268 PF10026.9 AMD22470.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) Rpn3_C PF08375.11 AMD22471.1 - 1.9e-20 73.1 0.6 7e-20 71.2 0.3 2.0 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 AMD22471.1 - 4.7e-20 72.1 0.8 1.7e-19 70.2 0.8 2.0 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 AMD22471.1 - 0.073 13.2 3.0 4.5 7.6 0.7 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Med17 PF10156.9 AMD22472.1 - 1.4e-156 521.9 13.9 1.7e-156 521.6 13.9 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Osmo_CC PF08946.10 AMD22472.1 - 1.6 9.0 8.2 0.28 11.5 0.6 3.2 3 1 0 3 3 3 0 Osmosensory transporter coiled coil Ilm1 PF10311.9 AMD22473.1 - 2.6e-09 36.9 10.6 9.4e-07 28.6 10.6 2.1 1 1 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 DUF3147 PF11345.8 AMD22473.1 - 0.039 14.3 0.2 0.068 13.5 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3147) JmjC PF02373.22 AMD22474.1 - 1.5e-39 135.0 0.5 3.5e-39 133.8 0.5 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 AMD22474.1 - 8.6e-11 41.6 0.0 2.3e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 AMD22474.1 - 1.5e-09 37.6 9.5 1.5e-09 37.6 9.5 2.4 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 AMD22474.1 - 0.00075 19.0 8.5 0.00075 19.0 4.2 2.7 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 AMD22474.1 - 0.012 15.9 10.1 0.054 13.8 10.1 2.2 1 0 0 1 1 1 0 Ring finger domain Zf_RING PF16744.5 AMD22474.1 - 0.022 14.9 6.7 0.057 13.5 6.7 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger Fer4_16 PF13484.6 AMD22474.1 - 0.024 15.5 2.3 0.024 15.5 2.3 3.0 2 0 0 2 2 1 0 4Fe-4S double cluster binding domain XRN_M PF17846.1 AMD22474.1 - 0.057 12.4 4.5 0.094 11.7 4.5 1.2 1 0 0 1 1 1 0 Xrn1 helical domain DUF4047 PF13256.6 AMD22474.1 - 0.078 13.2 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) DUF4746 PF15928.5 AMD22474.1 - 0.084 12.3 6.8 0.16 11.4 6.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PHD_3 PF13922.6 AMD22474.1 - 0.13 12.6 6.2 0.38 11.2 6.2 1.7 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Zip PF02535.22 AMD22474.1 - 0.15 11.3 1.0 0.24 10.6 1.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 AMD22474.1 - 0.51 9.3 2.5 0.93 8.4 2.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SDA1 PF05285.12 AMD22474.1 - 0.89 8.9 16.6 0.016 14.7 8.6 1.9 2 0 0 2 2 2 0 SDA1 zf-rbx1 PF12678.7 AMD22474.1 - 1.6 9.1 12.0 0.12 12.7 6.3 2.1 2 0 0 2 2 1 0 RING-H2 zinc finger domain Presenilin PF01080.17 AMD22474.1 - 5 5.8 8.4 3.8 6.2 6.4 1.6 2 0 0 2 2 2 0 Presenilin Prok-RING_1 PF14446.6 AMD22474.1 - 5.9 6.9 15.1 0.28 11.1 7.3 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 RNA_pol_3_Rpc31 PF11705.8 AMD22474.1 - 6.1 7.0 17.3 0.44 10.7 11.9 1.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 zf-HC5HC2H PF13771.6 AMD22474.1 - 8.9 6.7 12.1 1 9.7 4.9 2.6 2 0 0 2 2 2 0 PHD-like zinc-binding domain P5CR_dimer PF14748.6 AMD22475.1 - 3.3e-32 110.8 0.8 6e-32 110.0 0.8 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 AMD22475.1 - 1.1e-10 41.9 0.1 3.2e-10 40.4 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 AMD22475.1 - 0.034 13.8 0.2 0.075 12.7 0.2 1.5 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF5583 PF17821.1 AMD22475.1 - 0.065 13.2 0.1 0.34 10.8 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5583) zf-RING_2 PF13639.6 AMD22477.1 - 0.0024 18.2 2.2 0.0065 16.8 2.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AMD22477.1 - 0.016 15.1 3.4 0.05 13.5 3.4 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 AMD22477.1 - 0.076 12.9 3.3 0.18 11.7 3.3 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.5 AMD22477.1 - 0.084 12.6 1.2 0.29 10.9 1.2 2.0 1 0 0 1 1 1 0 RING-like zinc finger zf-UDP PF14569.6 AMD22477.1 - 0.92 9.7 2.8 2.3 8.4 2.8 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger Peptidase_S64 PF08192.11 AMD22478.1 - 3.4e-235 782.8 0.3 4.1e-235 782.5 0.3 1.0 1 0 0 1 1 1 1 Peptidase family S64 6PF2K PF01591.18 AMD22479.1 - 1.2e-84 283.1 0.0 1.7e-84 282.6 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AMD22479.1 - 9.7e-36 123.3 0.0 1.4e-35 122.7 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AMD22479.1 - 3.1e-05 24.2 0.0 6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Vps35 PF03635.17 AMD22480.1 - 1.5e-271 903.1 22.0 1.8e-271 902.9 22.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Pam17 PF08566.10 AMD22481.1 - 5.2e-66 221.6 0.1 6.1e-66 221.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 F-box-like PF12937.7 AMD22482.1 - 5e-08 32.7 3.0 1.3e-07 31.4 0.3 2.8 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 AMD22482.1 - 6.9e-07 29.0 0.0 3.1e-06 26.9 0.0 2.2 1 0 0 1 1 1 1 F-box domain Zn_clus PF00172.18 AMD22483.1 - 3.2e-09 36.8 8.8 8.6e-09 35.4 8.8 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Latarcin PF10279.9 AMD22483.1 - 0.078 13.4 0.1 0.21 12.0 0.1 1.7 1 0 0 1 1 1 0 Latarcin precursor Las1 PF04031.13 AMD22484.1 - 9.1e-45 152.5 0.1 1.9e-44 151.5 0.1 1.6 1 0 0 1 1 1 1 Las1-like DHR10 PF18595.1 AMD22484.1 - 0.0051 16.8 1.0 0.0098 15.9 1.0 1.5 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain Prefoldin_2 PF01920.20 AMD22484.1 - 0.37 10.8 6.3 1.1 9.2 0.9 2.7 2 0 0 2 2 2 0 Prefoldin subunit RNA_polI_A34 PF08208.11 AMD22485.1 - 3.9e-28 98.9 22.8 3.9e-28 98.9 22.8 1.5 2 0 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 DDHD PF02862.17 AMD22485.1 - 0.19 11.8 6.1 0.28 11.3 6.1 1.3 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 AMD22485.1 - 1.3 7.2 13.0 1.7 6.9 13.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 AMD22485.1 - 2.4 6.8 7.4 2.6 6.7 7.4 1.2 1 0 0 1 1 1 0 Presenilin SspB PF04386.13 AMD22485.1 - 2.8 7.8 9.8 7 6.5 9.8 1.7 1 0 0 1 1 1 0 Stringent starvation protein B CPSF100_C PF13299.6 AMD22485.1 - 3.8 7.7 12.8 2 8.6 9.9 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal TFA2_Winged_2 PF18121.1 AMD22486.1 - 2.1e-19 69.0 0.1 5.3e-19 67.7 0.0 1.7 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 AMD22486.1 - 1.9e-12 47.3 0.3 4.7e-12 46.0 0.3 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain DUF1639 PF07797.14 AMD22486.1 - 0.041 13.9 0.1 0.091 12.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) Peptidase_M16_M PF16187.5 AMD22486.1 - 0.093 12.0 0.5 3.1 7.0 0.1 2.1 1 1 1 2 2 2 0 Middle or third domain of peptidase_M16 Herpes_U44 PF04533.13 AMD22487.1 - 0.0029 17.2 0.3 1 8.9 0.0 2.5 3 0 0 3 3 3 2 Herpes virus U44 protein SseC PF04888.12 AMD22487.1 - 0.17 11.4 1.1 0.25 10.9 1.1 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family ACP_PD PF04336.12 AMD22487.1 - 0.27 11.7 1.8 6.3 7.3 0.1 3.1 3 0 0 3 3 3 0 Acyl carrier protein phosphodiesterase UPF0184 PF03670.13 AMD22487.1 - 0.35 11.3 4.4 14 6.2 0.0 3.4 4 1 1 5 5 5 0 Uncharacterised protein family (UPF0184) CRAL_TRIO PF00650.20 AMD22489.1 - 5.9e-23 81.3 0.0 8.3e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AMD22489.1 - 0.062 13.5 0.1 0.19 12.0 0.1 1.9 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain SHNi-TPR PF10516.9 AMD22489.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 SHNi-TPR Tim17 PF02466.19 AMD22491.1 - 2.8e-31 108.2 7.0 3.6e-31 107.8 7.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Pkinase PF00069.25 AMD22492.1 - 4.5e-49 167.2 0.1 1.4e-48 165.6 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22492.1 - 6.8e-23 81.3 0.0 1.1e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AMD22492.1 - 0.0093 15.9 0.1 0.017 15.1 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AMD22492.1 - 0.037 13.6 0.5 0.037 13.6 0.5 2.4 3 0 0 3 3 3 0 Choline/ethanolamine kinase RIO1 PF01163.22 AMD22492.1 - 0.05 13.2 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family RNA_pol_Rpb4 PF03874.16 AMD22493.1 - 3.4e-36 124.3 4.2 6e-36 123.5 4.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb4 Glyco_transf_15 PF01793.16 AMD22494.1 - 7.6e-116 386.9 13.5 9.5e-116 386.6 13.5 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_L1 PF00687.21 AMD22495.1 - 1.3e-46 158.9 1.6 1.7e-46 158.6 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SEA PF01390.20 AMD22495.1 - 0.022 14.8 0.1 0.13 12.4 0.0 2.2 3 0 0 3 3 3 0 SEA domain D5_N PF08706.11 AMD22495.1 - 0.17 12.2 0.1 1 9.6 0.0 2.0 1 1 0 2 2 2 0 D5 N terminal like DEAD PF00270.29 AMD22496.1 - 3.4e-47 160.5 0.4 3.4e-47 160.5 0.4 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22496.1 - 2e-31 108.6 0.2 5.5e-30 104.0 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD22496.1 - 1.9e-07 31.2 0.0 3.2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 AMD22496.1 - 0.00018 21.8 0.3 0.0025 18.2 0.2 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AMD22496.1 - 0.00072 19.3 0.1 0.0014 18.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain UTP25 PF06862.12 AMD22496.1 - 0.0076 15.1 0.3 1.2 7.8 0.0 2.2 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 AMD22496.1 - 0.015 14.7 0.0 0.041 13.2 0.0 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Glyco_transf_8 PF01501.20 AMD22497.1 - 1.1e-22 80.8 0.0 3.7e-22 79.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 8 Gasdermin PF04598.12 AMD22497.1 - 0.009 15.5 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Gasdermin pore forming domain Ribosomal_S21e PF01249.18 AMD22498.1 - 4.6e-40 135.6 0.0 5.1e-40 135.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e AFG1_ATPase PF03969.16 AMD22499.1 - 1.2e-76 258.0 0.0 2.6e-73 247.0 0.0 2.4 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 AMD22499.1 - 0.00023 21.6 0.4 0.0024 18.3 0.4 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AMD22499.1 - 0.0044 17.3 0.2 0.019 15.3 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 AMD22499.1 - 0.0063 16.9 0.0 0.016 15.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 AMD22499.1 - 0.015 15.3 0.0 0.034 14.0 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 AMD22499.1 - 0.056 13.8 0.0 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase TsaE PF02367.17 AMD22499.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TPR_14 PF13428.6 AMD22500.1 - 4.4e-11 42.6 0.2 0.057 14.3 0.0 8.2 7 2 2 9 9 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 AMD22500.1 - 2.3e-06 27.4 1.2 0.0014 18.7 0.1 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 AMD22500.1 - 0.0007 19.6 9.8 1.6 8.7 0.3 5.8 6 1 1 7 7 7 2 Mad3/BUB1 homology region 1 TPR_19 PF14559.6 AMD22500.1 - 0.0027 18.2 0.9 1.3 9.6 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 AMD22500.1 - 0.0042 17.4 0.8 2.9 8.3 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 AMD22500.1 - 0.0055 17.0 11.5 0.5 10.9 0.4 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD22500.1 - 0.015 15.4 8.0 0.19 11.9 0.2 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat RPN7 PF10602.9 AMD22500.1 - 0.031 14.0 4.2 0.2 11.4 0.0 3.9 5 0 0 5 5 5 0 26S proteasome subunit RPN7 NRDE-2 PF08424.10 AMD22500.1 - 0.038 13.1 15.5 0.068 12.3 0.3 5.2 5 1 1 6 6 6 0 NRDE-2, necessary for RNA interference Suf PF05843.14 AMD22500.1 - 0.045 13.7 12.9 4 7.3 0.3 4.9 5 0 0 5 5 5 0 Suppressor of forked protein (Suf) SinI PF08671.10 AMD22500.1 - 0.051 13.4 0.2 0.12 12.2 0.2 1.6 1 0 0 1 1 1 0 Anti-repressor SinI TPR_1 PF00515.28 AMD22500.1 - 0.056 13.3 1.1 3 7.8 0.4 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Rh5 PF18515.1 AMD22500.1 - 0.07 12.4 4.0 1.8 7.8 0.5 2.5 2 0 0 2 2 2 0 Rh5 coiled-coil domain TPR_6 PF13174.6 AMD22500.1 - 0.096 13.4 1.6 61 4.6 0.0 5.0 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 AMD22500.1 - 0.12 12.5 0.4 23 5.3 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat ATP-synt_D PF01813.17 AMD22501.1 - 8e-69 231.4 1.4 9.5e-69 231.2 1.4 1.1 1 0 0 1 1 1 1 ATP synthase subunit D Ribosomal_L2_C PF03947.18 AMD22502.1 - 6.4e-52 175.0 1.4 1.6e-51 173.8 1.4 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AMD22502.1 - 3.5e-27 94.2 0.6 1.4e-26 92.3 0.4 2.1 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain EXS PF03124.14 AMD22503.1 - 1.7e-58 198.5 22.3 2e-58 198.3 22.3 1.0 1 0 0 1 1 1 1 EXS family Nop25 PF09805.9 AMD22504.1 - 1.4e-33 116.3 17.1 1.4e-33 116.3 17.1 1.6 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) CSRNP_N PF16019.5 AMD22504.1 - 0.05 13.5 5.3 0.077 12.9 5.3 1.4 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Thioredoxin PF00085.20 AMD22505.1 - 1.6e-27 95.5 0.0 2.5e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin DER1 PF04511.15 AMD22505.1 - 2.4e-19 70.0 18.6 3.3e-19 69.6 18.6 1.1 1 0 0 1 1 1 1 Der1-like family Thioredoxin_2 PF13098.6 AMD22505.1 - 7.3e-06 26.4 0.1 4.1e-05 24.0 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 AMD22505.1 - 0.00013 21.9 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 AMD22505.1 - 0.0011 19.3 0.1 0.025 14.9 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like DIM1 PF02966.16 AMD22505.1 - 0.0022 17.8 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 Mitosis protein DIM1 Redoxin PF08534.10 AMD22505.1 - 0.0049 16.6 0.0 0.0097 15.6 0.0 1.5 1 0 0 1 1 1 1 Redoxin Glutaredoxin PF00462.24 AMD22505.1 - 0.0075 16.5 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_7 PF13899.6 AMD22505.1 - 0.016 15.4 0.1 0.032 14.4 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.6 AMD22505.1 - 0.075 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Phosducin PF02114.16 AMD22505.1 - 0.1 11.5 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Phosducin TraF PF13728.6 AMD22505.1 - 0.15 11.9 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Carn_acyltransf PF00755.20 AMD22506.1 - 4.3e-172 573.8 0.0 5e-172 573.6 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-HIT PF04438.16 AMD22507.1 - 0.0043 16.9 11.3 0.0043 16.9 11.3 2.0 2 0 0 2 2 2 1 HIT zinc finger ICMT PF04140.14 AMD22508.1 - 4.6e-30 103.9 0.9 8.2e-30 103.1 0.9 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 AMD22508.1 - 1.1e-14 54.7 1.4 1.1e-14 54.7 1.4 1.7 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 AMD22508.1 - 0.00027 20.6 2.6 0.00034 20.2 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PINIT PF14324.6 AMD22509.1 - 1.5e-33 116.1 2.1 5.1e-33 114.5 0.1 2.6 2 1 0 2 2 2 1 PINIT domain zf-MIZ PF02891.20 AMD22509.1 - 2e-21 75.5 5.5 3.4e-21 74.7 5.5 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 AMD22509.1 - 1.5e-11 43.7 0.1 2.6e-11 43.0 0.1 1.4 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.8 AMD22509.1 - 1.1e-06 28.3 1.8 2.5e-06 27.2 1.8 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 AMD22509.1 - 0.054 13.5 0.9 0.12 12.4 0.2 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AMD22509.1 - 0.062 13.1 3.5 0.13 12.1 3.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AMD22509.1 - 0.1 12.8 4.1 0.2 11.9 4.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Formyl_trans_N PF00551.19 AMD22510.1 - 1.8e-49 167.9 0.0 2.2e-49 167.7 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Proteasome PF00227.26 AMD22511.1 - 5.6e-49 166.2 0.0 8.5e-49 165.6 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 AMD22511.1 - 2.6e-10 39.5 0.1 2.6e-10 39.5 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal TRAPPC9-Trs120 PF08626.11 AMD22512.1 - 1.4e-252 840.9 14.7 1.7e-252 840.6 14.7 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TPR_12 PF13424.6 AMD22512.1 - 0.018 15.3 0.1 0.039 14.2 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat LSM PF01423.22 AMD22514.1 - 1.3e-12 47.2 0.1 1.5e-12 47.0 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AMD22514.1 - 0.016 14.8 0.1 0.028 14.1 0.1 1.4 1 0 0 1 1 1 0 Hfq protein Xpo1 PF08389.12 AMD22515.1 - 1.5e-30 106.2 2.1 4.1e-29 101.6 0.3 3.7 4 0 0 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 AMD22515.1 - 1.8e-08 34.2 0.2 2.5e-07 30.5 0.1 3.0 3 1 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.22 AMD22515.1 - 0.025 14.8 0.0 6.8 7.2 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat RNA_POL_M_15KD PF02150.16 AMD22515.1 - 0.77 9.7 3.7 9.1 6.2 0.1 2.8 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit Choline_transpo PF04515.12 AMD22517.1 - 6.3e-80 268.8 18.1 6.3e-80 268.8 18.1 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF4257 PF14074.6 AMD22517.1 - 0.95 9.7 7.1 0.23 11.7 0.9 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF4257) ISN1 PF06437.11 AMD22518.1 - 2.5e-161 537.2 0.0 3.6e-161 536.7 0.0 1.2 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase DDHD PF02862.17 AMD22520.1 - 4.5e-34 118.6 0.1 5e-24 85.7 0.0 2.6 1 1 1 2 2 2 2 DDHD domain LCAT PF02450.15 AMD22520.1 - 3.4e-06 26.5 0.0 3.6e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 AMD22520.1 - 5.8e-05 22.7 0.0 0.017 14.6 0.0 2.3 2 0 0 2 2 2 2 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AMD22520.1 - 0.014 15.3 0.0 0.071 12.9 0.0 2.0 2 0 0 2 2 2 0 Palmitoyl protein thioesterase PGAP1 PF07819.13 AMD22520.1 - 0.13 12.0 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein WWE PF02825.20 AMD22520.1 - 0.16 12.5 0.3 1.3 9.6 0.1 2.8 2 1 0 2 2 2 0 WWE domain RNA_Me_trans PF04252.13 AMD22521.1 - 1.5e-78 262.9 0.0 1.7e-78 262.8 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Cpn10 PF00166.21 AMD22522.1 - 9.4e-28 96.1 0.1 1.1e-27 96.0 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Hexapep PF00132.24 AMD22522.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) PRP3 PF08572.10 AMD22523.1 - 2.4e-56 191.0 18.4 4.1e-56 190.2 18.4 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 AMD22523.1 - 2.1e-28 99.3 0.4 2.1e-28 99.3 0.4 2.8 3 1 0 3 3 3 1 Protein of unknown function (DUF1115) Usp PF00582.26 AMD22524.1 - 0.014 15.9 0.7 0.075 13.5 0.0 2.5 2 1 0 2 2 2 0 Universal stress protein family Arf PF00025.21 AMD22525.1 - 1.7e-30 105.7 0.1 5.2e-29 100.9 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.22 AMD22525.1 - 2.9e-15 56.2 0.0 4.8e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22525.1 - 1.9e-11 44.2 0.0 3.3e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AMD22525.1 - 5.1e-09 36.2 0.0 9.3e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 AMD22525.1 - 2.5e-06 26.9 0.2 0.00082 18.6 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 AMD22525.1 - 4.3e-06 26.4 0.0 0.00014 21.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AMD22525.1 - 0.0011 18.4 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 AMD22525.1 - 0.0036 17.4 0.2 0.14 12.2 0.0 2.3 1 1 0 2 2 2 1 Dynamin family Gtr1_RagA PF04670.12 AMD22525.1 - 0.0038 16.6 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 AMD22525.1 - 0.075 12.6 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF2470 PF10615.9 AMD22526.1 - 4.2e-18 65.7 0.1 6.4e-18 65.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pkinase PF00069.25 AMD22527.1 - 7.3e-75 251.7 0.1 1.2e-74 251.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain AdenylateSensor PF16579.5 AMD22527.1 - 2.1e-57 192.7 0.1 6e-57 191.2 0.1 1.9 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 AMD22527.1 - 3e-37 128.3 0.0 4.8e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 AMD22527.1 - 1.6e-17 63.3 2.1 1.6e-17 63.3 2.1 1.9 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 AMD22527.1 - 1.3e-09 37.8 0.0 3e-09 36.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like YukC PF10140.9 AMD22527.1 - 0.0001 21.3 0.6 0.00019 20.4 0.6 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Haspin_kinase PF12330.8 AMD22527.1 - 0.00018 20.6 0.3 0.00032 19.7 0.3 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 AMD22527.1 - 0.00027 20.6 0.7 0.00055 19.6 0.7 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 AMD22527.1 - 0.0033 16.8 0.2 0.0059 16.0 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AMD22527.1 - 0.01 15.8 0.2 0.61 10.0 0.2 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family ABC1 PF03109.16 AMD22527.1 - 0.013 15.6 0.1 7.2 6.8 0.0 2.6 2 0 0 2 2 2 0 ABC1 family SIR2 PF02146.17 AMD22528.1 - 1.1e-37 129.7 0.0 8.5e-37 126.8 0.0 2.1 1 1 0 1 1 1 1 Sir2 family DUF2256 PF10013.9 AMD22528.1 - 0.052 13.7 1.1 0.085 13.0 0.3 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Rpr2 PF04032.16 AMD22529.1 - 3.4e-11 43.3 4.0 3.2e-10 40.2 1.1 2.2 2 0 0 2 2 2 2 RNAse P Rpr2/Rpp21/SNM1 subunit domain PHD_Oberon PF07227.11 AMD22529.1 - 0.24 11.3 6.4 2.9 7.8 2.3 2.3 1 1 1 2 2 2 0 PHD - plant homeodomain finger protein Pex24p PF06398.11 AMD22530.1 - 4.4e-83 279.3 8.3 6.2e-83 278.8 8.3 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin WD40 PF00400.32 AMD22531.1 - 1.1e-05 26.0 7.8 0.16 12.9 0.0 4.3 5 0 0 5 5 5 3 WD domain, G-beta repeat PQQ_3 PF13570.6 AMD22531.1 - 0.0025 18.3 1.9 7.7 7.2 0.1 3.9 4 0 0 4 4 4 2 PQQ-like domain SET PF00856.28 AMD22532.1 - 1.8e-19 70.7 0.1 3.5e-19 69.8 0.1 1.5 1 0 0 1 1 1 1 SET domain MRG PF05712.13 AMD22532.1 - 0.19 11.0 1.3 9.5 5.5 0.0 2.7 2 0 0 2 2 2 0 MRG HBS1_N PF08938.10 AMD22532.1 - 5.1 7.5 8.2 7.7 6.9 5.9 2.5 2 1 0 2 2 2 0 HBS1 N-terminus TPR_1 PF00515.28 AMD22533.1 - 6.9e-47 155.4 25.8 4.2e-09 35.9 0.7 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 AMD22533.1 - 1.3e-40 134.2 27.2 8e-08 31.8 0.6 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 AMD22533.1 - 2.4e-36 123.5 17.3 6.2e-18 64.5 1.8 2.8 2 0 0 2 2 2 2 STI1 domain TPR_12 PF13424.6 AMD22533.1 - 2e-24 85.7 12.5 5.9e-11 42.5 0.4 6.3 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 AMD22533.1 - 5.2e-22 78.2 10.2 0.00013 22.5 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 AMD22533.1 - 4e-19 67.2 29.3 3.7e-05 23.6 0.5 9.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 AMD22533.1 - 4.8e-19 66.9 12.7 1.2e-05 25.0 0.0 8.2 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 AMD22533.1 - 9.3e-19 66.8 33.0 0.00092 18.9 2.6 8.8 6 3 3 9 9 9 6 TPR repeat TPR_14 PF13428.6 AMD22533.1 - 2.4e-16 59.0 8.3 0.039 14.8 0.2 9.2 5 2 4 9 9 9 3 Tetratricopeptide repeat TPR_10 PF13374.6 AMD22533.1 - 7.1e-15 54.3 13.0 0.0027 17.5 0.3 7.6 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 AMD22533.1 - 2e-12 47.4 20.8 0.00013 22.4 0.1 7.0 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 AMD22533.1 - 1.5e-11 44.2 2.8 6.9e-05 22.9 0.0 5.3 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 AMD22533.1 - 9.4e-11 41.3 12.7 0.0043 17.3 0.0 7.1 7 1 0 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD22533.1 - 8.1e-08 32.4 16.8 0.0014 18.8 0.7 5.3 2 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 AMD22533.1 - 2.1e-07 31.2 19.5 1.9 9.3 0.0 8.9 9 0 0 9 9 9 1 Tetratricopeptide repeat RPN7 PF10602.9 AMD22533.1 - 0.00023 20.9 16.2 0.25 11.0 1.1 5.2 2 2 3 5 5 5 2 26S proteasome subunit RPN7 TPR_3 PF07720.12 AMD22533.1 - 0.00023 21.1 15.2 0.8 9.8 0.3 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF3808 PF10300.9 AMD22533.1 - 0.00062 18.6 5.7 0.001 17.9 0.2 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF3808) BTAD PF03704.17 AMD22533.1 - 0.0011 19.4 8.9 0.13 12.7 0.1 4.9 3 2 1 4 4 4 1 Bacterial transcriptional activator domain SHNi-TPR PF10516.9 AMD22533.1 - 0.0053 16.2 9.6 1.8 8.1 0.1 6.0 7 0 0 7 7 6 1 SHNi-TPR MIT PF04212.18 AMD22533.1 - 0.0058 16.7 21.7 6.8 6.9 0.1 7.3 6 1 0 6 6 6 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 AMD22533.1 - 0.0083 16.2 11.5 1.7 8.8 0.2 5.8 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 AMD22533.1 - 0.024 15.0 10.7 0.15 12.4 0.2 4.9 4 2 1 5 5 5 0 Tetratricopeptide repeat Mgm101p PF06420.12 AMD22533.1 - 0.029 13.9 0.0 1.5 8.4 0.0 3.0 3 0 0 3 3 3 0 Mitochondrial genome maintenance MGM101 PPR PF01535.20 AMD22533.1 - 0.029 14.6 5.9 13 6.3 0.1 6.0 6 0 0 6 6 6 0 PPR repeat Sel1 PF08238.12 AMD22533.1 - 0.098 13.4 5.2 9.3 7.1 0.0 4.4 4 0 0 4 4 3 0 Sel1 repeat DUF3856 PF12968.7 AMD22533.1 - 0.2 11.7 10.3 5.4 7.1 1.1 5.3 2 2 1 4 4 4 0 Domain of Unknown Function (DUF3856) Med9 PF07544.13 AMD22533.1 - 0.25 11.5 3.0 5.9 7.1 1.5 3.5 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF5082 PF16888.5 AMD22533.1 - 2.1 8.6 10.8 9.3 6.6 0.2 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) DUF5113 PF17140.4 AMD22533.1 - 4.7 7.0 9.5 3 7.6 0.4 3.6 3 2 0 3 3 3 0 Domain of unknown function (DUF5113) AAA_2 PF07724.14 AMD22534.1 - 3.1e-51 173.9 0.2 2.9e-49 167.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AMD22534.1 - 2.5e-34 117.3 1.0 2.5e-34 117.3 1.0 2.6 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 AMD22534.1 - 1.7e-27 95.3 2.7 3.1e-27 94.4 0.2 2.6 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 AMD22534.1 - 2.6e-21 76.4 0.1 1.3e-10 41.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AMD22534.1 - 4.3e-16 59.2 0.3 3.3e-11 43.3 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AMD22534.1 - 3.3e-10 40.6 2.4 0.00035 21.0 0.1 3.8 2 2 2 4 4 4 2 AAA ATPase domain Sigma54_activat PF00158.26 AMD22534.1 - 4.6e-07 29.7 0.1 4.7e-05 23.1 0.0 2.5 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 AMD22534.1 - 8.7e-07 29.3 0.2 0.045 14.0 0.1 3.4 2 2 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AMD22534.1 - 1.4e-06 28.2 0.0 0.014 15.1 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein TniB PF05621.11 AMD22534.1 - 6e-06 25.8 0.0 0.0018 17.8 0.0 3.4 2 1 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 AMD22534.1 - 7.4e-06 25.6 0.2 0.026 14.0 0.0 3.3 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_23 PF13476.6 AMD22534.1 - 1e-05 26.2 5.6 0.48 10.9 0.0 3.6 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 AMD22534.1 - 1.5e-05 25.0 0.4 0.035 14.0 0.1 3.1 3 0 0 3 3 2 2 RsgA GTPase AAA_30 PF13604.6 AMD22534.1 - 1.9e-05 24.5 0.3 0.089 12.5 0.0 3.2 3 1 1 4 4 3 2 AAA domain ATPase_2 PF01637.18 AMD22534.1 - 2e-05 24.7 7.7 0.24 11.3 0.1 4.4 4 1 0 4 4 3 2 ATPase domain predominantly from Archaea AAA_14 PF13173.6 AMD22534.1 - 3.9e-05 23.7 0.0 0.1 12.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain ABC_tran PF00005.27 AMD22534.1 - 5.7e-05 23.6 1.0 0.55 10.7 0.0 3.7 3 1 0 3 3 3 1 ABC transporter AAA_18 PF13238.6 AMD22534.1 - 6e-05 23.6 0.6 0.54 10.8 0.0 3.6 3 1 0 3 3 3 2 AAA domain TsaE PF02367.17 AMD22534.1 - 7.4e-05 22.8 0.0 0.71 9.9 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 AMD22534.1 - 8.8e-05 22.5 0.0 0.097 12.6 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_29 PF13555.6 AMD22534.1 - 0.00049 19.8 0.0 0.17 11.7 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Roc PF08477.13 AMD22534.1 - 0.00054 20.2 0.0 1.1 9.5 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 AMD22534.1 - 0.00059 20.2 0.0 1.3 9.5 0.0 3.0 3 0 0 3 3 2 1 RNA helicase PduV-EutP PF10662.9 AMD22534.1 - 0.00063 19.5 0.0 0.33 10.7 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 AMD22534.1 - 0.00074 19.8 0.0 0.44 10.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 AMD22534.1 - 0.0012 18.8 0.2 1.1 8.9 0.0 3.3 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Mg_chelatase PF01078.21 AMD22534.1 - 0.0021 17.5 0.1 0.59 9.5 0.0 3.2 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 AMD22534.1 - 0.0025 17.0 2.8 0.62 9.2 0.3 3.7 2 2 0 2 2 2 1 Protein of unknown function (DUF815) SRP54 PF00448.22 AMD22534.1 - 0.0037 16.9 0.0 1.3 8.7 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 AMD22534.1 - 0.0064 16.6 0.2 3 8.0 0.1 3.2 2 2 0 2 2 2 1 50S ribosome-binding GTPase AAA_24 PF13479.6 AMD22534.1 - 0.0095 15.7 0.0 3.2 7.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_6 PF12774.7 AMD22534.1 - 0.01 14.8 1.2 0.11 11.5 0.0 2.9 4 0 0 4 4 4 0 Hydrolytic ATP binding site of dynein motor region Zeta_toxin PF06414.12 AMD22534.1 - 0.012 14.9 0.1 0.19 11.0 0.0 2.6 3 0 0 3 3 2 0 Zeta toxin AAA_25 PF13481.6 AMD22534.1 - 0.015 14.9 0.0 0.78 9.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_19 PF13245.6 AMD22534.1 - 0.017 15.5 1.5 7.2 6.9 0.3 3.5 2 2 1 3 3 2 0 AAA domain AAA_3 PF07726.11 AMD22534.1 - 0.021 14.7 0.1 0.37 10.7 0.1 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 AMD22534.1 - 0.025 13.7 0.1 0.13 11.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein PhoH PF02562.16 AMD22534.1 - 0.031 13.7 0.0 1.9 7.9 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein Torsin PF06309.11 AMD22534.1 - 0.038 14.1 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 Torsin ResIII PF04851.15 AMD22534.1 - 0.039 14.0 2.9 0.96 9.4 0.0 3.7 3 2 1 5 5 3 0 Type III restriction enzyme, res subunit Bac_DnaA PF00308.18 AMD22534.1 - 0.039 13.8 0.0 6.3 6.6 0.0 2.7 2 0 0 2 2 2 0 Bacterial dnaA protein DUF853 PF05872.12 AMD22534.1 - 0.045 12.4 0.2 1 7.9 0.0 2.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) AAA_33 PF13671.6 AMD22534.1 - 0.046 13.9 0.0 5.6 7.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 AMD22534.1 - 0.062 13.1 0.0 11 5.7 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein LacI PF00356.21 AMD22534.1 - 0.14 11.9 0.0 16 5.4 0.0 3.4 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family HIP1_clath_bdg PF16515.5 AMD22534.1 - 0.27 11.9 5.4 1.1 9.9 5.4 2.2 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NTPase_1 PF03266.15 AMD22534.1 - 0.37 10.7 4.5 12 5.8 0.0 3.6 4 0 0 4 4 4 0 NTPase DivIC PF04977.15 AMD22534.1 - 9.7 6.0 7.2 9.3 6.1 5.0 2.1 1 1 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.21 AMD22535.1 - 3.2e-08 33.5 19.4 3e-07 30.4 19.4 2.2 1 1 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 AMD22535.1 - 0.21 12.1 14.9 0.06 13.9 9.0 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor WD40 PF00400.32 AMD22536.1 - 2.6e-59 195.8 40.6 2.8e-11 43.8 0.4 9.1 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22536.1 - 1.4e-20 73.3 3.7 8.5e-05 22.8 0.2 5.7 3 2 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 AMD22536.1 - 1.9e-09 37.9 0.0 3.6e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 AMD22536.1 - 4.5e-08 33.2 0.9 0.00016 21.6 0.0 3.4 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AMD22536.1 - 2.2e-06 26.9 0.5 0.11 11.4 0.2 4.2 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 AMD22536.1 - 0.00014 20.7 0.4 0.0085 14.9 0.1 2.9 1 1 1 2 2 2 1 Nup133 N terminal like Nup160 PF11715.8 AMD22536.1 - 0.00027 19.7 3.9 2 6.9 0.5 4.7 2 1 2 5 5 5 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 AMD22536.1 - 0.00029 19.5 0.0 0.14 10.6 0.1 2.9 2 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 AMD22536.1 - 0.00072 19.4 0.3 2.8 8.0 0.0 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 AMD22536.1 - 0.0029 17.0 1.5 0.26 10.6 0.1 2.9 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 AMD22536.1 - 0.024 12.9 0.0 1.9 6.7 0.0 2.8 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 AMD22536.1 - 0.032 13.6 0.0 2.5 7.3 0.0 2.6 2 0 0 2 2 2 0 WD40-like domain DPPIV_N PF00930.21 AMD22536.1 - 0.12 11.1 0.3 17 4.0 0.0 2.9 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pkinase PF00069.25 AMD22537.1 - 3.7e-64 216.6 0.0 8.2e-64 215.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22537.1 - 4.8e-32 111.2 0.0 8.5e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD22537.1 - 0.0039 16.5 0.0 0.029 13.7 0.0 2.3 2 1 0 2 2 2 1 Kinase-like Metallophos PF00149.28 AMD22538.1 - 2.1e-34 119.9 0.4 3.2e-34 119.2 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AMD22538.1 - 0.1 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain ubiquitin PF00240.23 AMD22539.1 - 5.6e-07 29.2 0.1 6.6e-07 29.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AMD22539.1 - 0.00029 20.6 0.1 0.00032 20.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 AMD22539.1 - 0.0053 17.4 0.1 0.0065 17.1 0.1 1.1 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.6 AMD22539.1 - 0.079 13.4 0.2 0.49 10.9 0.2 2.0 1 1 0 1 1 1 0 Ubiquitin-like domain Chorismate_bind PF00425.18 AMD22540.1 - 4e-66 223.2 0.0 8.2e-66 222.2 0.0 1.5 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 AMD22540.1 - 4.9e-33 114.5 0.0 7.3e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 AMD22540.1 - 7e-14 52.2 0.0 3.2e-13 50.1 0.0 2.1 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 AMD22540.1 - 2.2e-09 37.4 0.0 4.3e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 Glucosamine_iso PF01182.20 AMD22541.1 - 1e-55 189.1 0.0 3e-54 184.3 0.0 2.0 1 1 1 2 2 2 2 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PQ-loop PF04193.14 AMD22542.1 - 2.4e-19 68.9 8.5 9.3e-11 41.3 0.1 2.7 3 0 0 3 3 3 2 PQ loop repeat YpmT PF17431.2 AMD22542.1 - 0.0046 16.9 0.3 0.0046 16.9 0.3 2.5 3 0 0 3 3 3 1 Uncharacterized YmpT-like MpPF26 PF07666.11 AMD22542.1 - 0.094 12.8 0.2 0.094 12.8 0.2 2.8 2 1 1 3 3 3 0 M penetrans paralogue family 26 LMBR1 PF04791.16 AMD22543.1 - 6.9e-36 124.2 18.2 2e-35 122.7 18.2 1.6 1 1 0 1 1 1 1 LMBR1-like membrane protein DUF4106 PF13388.6 AMD22543.1 - 0.018 14.3 0.1 0.027 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) DUF3215 PF11503.8 AMD22544.1 - 5.7e-28 96.6 0.1 6.3e-28 96.4 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) HhH-GPD PF00730.25 AMD22544.1 - 0.066 13.7 0.0 0.075 13.5 0.0 1.1 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein PI31_Prot_C PF08577.11 AMD22545.1 - 8.1e-06 26.9 13.3 8.1e-06 26.9 13.3 2.1 2 1 0 2 2 2 1 PI31 proteasome regulator PAT1 PF09770.9 AMD22546.1 - 5.5e-77 259.9 63.8 5.2e-74 250.0 63.8 5.1 1 1 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Vinculin PF01044.19 AMD22546.1 - 0.44 8.7 6.2 0.77 7.9 6.2 1.3 1 0 0 1 1 1 0 Vinculin family P34-Arc PF04045.14 AMD22547.1 - 4.2e-92 308.2 0.6 6.5e-92 307.6 0.6 1.3 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Ribosom_S12_S23 PF00164.25 AMD22548.1 - 1.6e-33 114.7 0.7 2.1e-33 114.3 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 PP2C PF00481.21 AMD22549.1 - 1.8e-31 109.7 0.0 1.6e-27 96.8 0.0 2.5 1 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 AMD22549.1 - 0.015 14.9 0.0 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 Protein phosphatase 2C Ribosomal_S19 PF00203.21 AMD22550.1 - 2.4e-25 88.2 0.0 2.9e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 DEAD PF00270.29 AMD22551.1 - 9.8e-41 139.4 0.5 1.7e-40 138.7 0.5 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22551.1 - 4e-21 75.5 0.1 1.5e-20 73.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD22551.1 - 2.9e-11 43.7 0.0 2.9e-11 43.7 0.0 2.9 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 AMD22551.1 - 0.00048 20.1 0.9 0.005 16.8 0.2 2.6 1 1 1 2 2 2 1 Flavivirus DEAD domain SDA1 PF05285.12 AMD22551.1 - 0.065 12.7 15.5 0.097 12.1 15.5 1.2 1 0 0 1 1 1 0 SDA1 UvrD-helicase PF00580.21 AMD22551.1 - 8.1 5.9 12.7 0.15 11.5 1.4 2.6 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain Med12 PF09497.10 AMD22552.1 - 1.2e-23 83.2 0.1 2.8e-23 82.0 0.1 1.7 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Cation_efflux PF01545.21 AMD22553.1 - 1.7e-08 34.5 11.7 2.8e-08 33.7 11.7 1.3 1 0 0 1 1 1 1 Cation efflux family UbiA PF01040.18 AMD22556.1 - 2.1e-48 164.9 11.5 2.7e-48 164.5 11.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family MDD_C PF18376.1 AMD22557.1 - 1.1e-69 233.9 0.6 1.6e-69 233.4 0.6 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 AMD22557.1 - 4.8e-10 39.5 1.1 1.3e-09 38.2 1.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain Zn_clus PF00172.18 AMD22558.1 - 1.3e-08 34.8 8.7 2e-08 34.2 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 AMD22558.1 - 0.057 12.4 0.1 0.13 11.3 0.1 1.5 1 0 0 1 1 1 0 Fungal specific transcription factor domain WD40 PF00400.32 AMD22559.1 - 6.7e-50 166.0 14.0 4.9e-09 36.7 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 AMD22559.1 - 5.1e-29 100.4 11.2 7.8e-29 99.8 11.2 1.3 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 AMD22559.1 - 3.7e-14 52.8 0.0 0.00028 21.1 0.0 5.6 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD22559.1 - 4.9e-08 32.1 0.7 0.12 11.0 0.0 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 AMD22559.1 - 0.00015 21.2 0.0 0.23 10.8 0.0 3.6 3 1 1 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 AMD22559.1 - 0.024 13.6 0.1 14 4.5 0.0 3.6 1 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HDV_ag PF01517.18 AMD22559.1 - 0.032 14.0 0.0 0.069 12.9 0.0 1.5 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen DUF724 PF05266.14 AMD22559.1 - 0.76 9.6 6.0 1.2 8.9 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Csm1_N PF18504.1 AMD22560.1 - 7.7e-25 87.0 7.4 1.6e-24 86.0 7.4 1.5 1 0 0 1 1 1 1 Csm1 N-terminal domain Csm1 PF12539.8 AMD22560.1 - 2.8e-24 85.6 0.0 4.1e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 Spc24 PF08286.11 AMD22560.1 - 0.0082 16.4 0.4 0.012 15.8 0.3 1.3 1 1 0 1 1 1 1 Spc24 subunit of Ndc80 IES5 PF17335.2 AMD22560.1 - 0.019 15.2 0.5 0.032 14.5 0.5 1.4 1 0 0 1 1 1 0 Ino80 complex subunit 5 DUF16 PF01519.16 AMD22560.1 - 0.029 14.8 2.8 0.053 14.0 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 YjcZ PF13990.6 AMD22560.1 - 0.034 13.5 1.1 0.05 13.0 1.1 1.2 1 0 0 1 1 1 0 YjcZ-like protein Nup88 PF10168.9 AMD22560.1 - 0.055 11.3 5.1 0.07 10.9 5.1 1.1 1 0 0 1 1 1 0 Nuclear pore component HrpB2 PF09487.10 AMD22560.1 - 0.079 13.4 0.1 0.12 12.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) Com_YlbF PF06133.11 AMD22560.1 - 0.1 13.2 4.6 0.15 12.7 3.8 1.7 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA DUF1043 PF06295.12 AMD22560.1 - 0.1 12.6 2.1 0.34 10.9 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) CENP-Q PF13094.6 AMD22560.1 - 0.32 11.2 6.1 0.34 11.1 5.7 1.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit zf-LYAR PF08790.11 AMD22561.1 - 3e-14 52.6 7.9 6e-14 51.6 7.9 1.5 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger PPL5 PF18168.1 AMD22561.1 - 0.0088 15.4 1.5 0.01 15.1 1.5 1.1 1 0 0 1 1 1 1 Prim-pol family 5 zf-met PF12874.7 AMD22561.1 - 0.089 13.2 3.9 2.1 8.9 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD22561.1 - 0.13 12.6 3.0 12 6.4 0.4 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 AMD22561.1 - 0.28 12.1 6.0 2.8 9.0 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AMD22561.1 - 4.5 7.9 6.1 6.3 7.5 1.2 2.6 2 1 0 2 2 2 0 Zinc finger, C2H2 type Presenilin PF01080.17 AMD22561.1 - 7.3 5.2 5.4 8 5.1 5.4 1.1 1 0 0 1 1 1 0 Presenilin TraV PF09676.10 AMD22561.1 - 8.9 7.3 15.1 0.064 14.2 7.2 1.5 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) Cofilin_ADF PF00241.20 AMD22562.1 - 4.6e-17 61.9 0.0 1.9e-16 59.9 0.0 2.1 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 AMD22562.1 - 1.5e-16 59.7 0.6 3.4e-16 58.6 0.6 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AMD22562.1 - 2.3e-15 56.2 0.4 5.4e-15 55.0 0.4 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AMD22562.1 - 3.8e-08 32.9 0.0 8.3e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Inhibitor_I53 PF11714.8 AMD22562.1 - 0.26 11.5 0.0 0.26 11.5 0.0 3.1 2 0 0 2 2 2 0 Thrombin inhibitor Madanin DUF866 PF05907.13 AMD22563.1 - 1.9e-43 148.1 3.9 2.5e-43 147.7 3.9 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Helicase_C PF00271.31 AMD22565.1 - 4.3e-12 46.3 0.0 1e-11 45.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SUV3_C PF12513.8 AMD22565.1 - 7.2e-11 41.8 0.5 1.7e-10 40.7 0.5 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal AdoMet_MTase PF07757.13 AMD22566.1 - 2.7e-41 140.4 0.1 4.6e-41 139.7 0.1 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_25 PF13649.6 AMD22566.1 - 0.025 15.2 0.0 27 5.5 0.0 3.4 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_32 PF13679.6 AMD22566.1 - 0.11 12.5 0.1 3.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 AMD22566.1 - 0.18 11.6 0.0 0.73 9.6 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.25 AMD22567.1 - 7.6e-76 254.9 0.0 9e-76 254.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22567.1 - 2.5e-36 125.3 0.0 3.5e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AMD22567.1 - 9.6e-05 21.8 0.2 0.00027 20.4 0.0 1.8 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 AMD22567.1 - 0.0027 16.7 0.0 0.031 13.2 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AMD22567.1 - 0.0054 16.7 0.1 0.14 12.1 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family ApbA_C PF08546.11 AMD22569.1 - 1.2e-05 25.5 0.0 2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal PAD PF03068.15 AMD22569.1 - 0.062 12.3 1.2 0.11 11.5 1.2 1.3 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) Atg14 PF10186.9 AMD22569.1 - 0.55 9.3 6.1 1.4 7.9 6.1 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DIT1_PvcA PF05141.12 AMD22569.1 - 1.1 8.7 5.9 4.1 6.8 4.2 2.3 3 0 0 3 3 3 0 Pyoverdine/dityrosine biosynthesis protein OmpH PF03938.14 AMD22569.1 - 3.6 7.9 16.6 2.7 8.3 11.6 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FapA PF03961.13 AMD22569.1 - 7.6 5.0 7.1 13 4.3 7.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A NAC PF01849.18 AMD22570.1 - 6.5e-18 64.5 0.2 1.3e-17 63.5 0.2 1.5 1 0 0 1 1 1 1 NAC domain Glyco_hydro_20b PF02838.15 AMD22570.1 - 0.024 15.4 0.1 0.04 14.7 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 zf-C2H2 PF00096.26 AMD22571.1 - 6.7e-09 35.7 6.1 0.00084 19.7 2.0 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22571.1 - 4.2e-08 33.4 4.5 0.0026 18.5 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 AMD22571.1 - 0.00053 20.7 1.8 0.0032 18.1 0.6 2.1 2 0 0 2 2 2 1 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 AMD22571.1 - 0.00099 19.4 0.5 0.45 11.0 0.0 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD22571.1 - 0.003 17.8 0.7 0.17 12.2 0.0 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 AMD22571.1 - 0.0047 17.3 5.4 0.15 12.5 0.6 3.4 3 1 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 AMD22571.1 - 0.0065 16.5 2.3 1.3 9.1 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 AMD22571.1 - 0.0084 15.9 4.0 0.69 9.7 0.1 2.6 2 0 0 2 2 2 2 zinc-finger C2H2-type LexA_DNA_bind PF01726.16 AMD22571.1 - 0.057 13.2 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 LexA DNA binding domain GAGA PF09237.11 AMD22571.1 - 0.083 12.7 0.3 0.31 10.9 0.1 2.0 2 0 0 2 2 2 0 GAGA factor Cache_3-Cache_2 PF17201.4 AMD22571.1 - 0.096 11.9 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain Lipl32 PF12103.8 AMD22571.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order tRNA-synt_1 PF00133.22 AMD22573.1 - 9.9e-153 509.6 0.1 1.4e-152 509.0 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AMD22573.1 - 3.3e-19 68.9 6.6 2.8e-12 46.1 0.0 4.0 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AMD22573.1 - 4.1e-17 62.6 0.1 1e-16 61.3 0.1 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 AMD22573.1 - 0.00072 19.1 0.0 0.0017 17.9 0.0 1.6 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 DUF1917 PF08939.10 AMD22573.1 - 0.023 14.6 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) zf-FPG_IleRS PF06827.14 AMD22573.1 - 0.17 11.8 3.8 0.4 10.6 3.8 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS FLILHELTA PF10306.9 AMD22574.1 - 5.4e-17 62.0 0.0 1.4e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA Pkinase PF00069.25 AMD22575.1 - 1.3e-58 198.5 0.2 1.6e-57 194.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22575.1 - 1.1e-28 100.2 0.0 5e-27 94.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AMD22575.1 - 0.0021 17.0 0.4 0.0035 16.3 0.4 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Imm7 PF15585.6 AMD22575.1 - 0.079 13.2 0.0 0.18 12.1 0.0 1.6 1 1 0 1 1 1 0 Immunity protein 7 RRM_1 PF00076.22 AMD22576.1 - 6.9e-59 195.6 0.8 2.6e-17 62.4 0.1 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD22576.1 - 4.2e-07 30.0 0.1 0.026 14.6 0.0 4.4 4 0 0 4 4 4 2 RNA recognition motif PHM7_cyt PF14703.6 AMD22576.1 - 6.9e-06 26.4 6.1 3.9 7.7 0.0 6.1 4 4 4 8 8 8 3 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 AMD22576.1 - 1e-05 25.4 0.1 0.024 14.4 0.0 3.4 3 1 0 3 3 3 2 Rrp7 RRM-like N-terminal domain CENP-N PF05238.13 AMD22577.1 - 2.1e-62 211.8 0.0 3.5e-62 211.0 0.0 1.4 1 1 0 1 1 1 1 Kinetochore protein CHL4 like Vps16_C PF04840.12 AMD22578.1 - 4.3e-81 272.4 6.9 4.3e-81 272.4 6.9 1.7 2 0 0 2 2 2 1 Vps16, C-terminal region Vps16_N PF04841.13 AMD22578.1 - 1e-60 205.7 0.0 1.8e-60 204.9 0.0 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region DUF1272 PF06906.11 AMD22578.1 - 0.042 13.9 0.1 0.098 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) ANAPC4_WD40 PF12894.7 AMD22578.1 - 0.068 13.5 0.0 1.2 9.5 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Skp1_POZ PF03931.15 AMD22579.1 - 1.1e-13 51.2 0.2 1.8e-13 50.5 0.0 1.4 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 AMD22579.1 - 0.012 15.9 0.1 0.024 14.9 0.1 1.5 1 1 0 1 1 1 0 BTB/POZ domain CLTH PF10607.9 AMD22580.1 - 3.3e-10 40.0 6.0 1.7e-09 37.7 1.0 2.8 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 AMD22580.1 - 0.00096 19.1 3.5 0.003 17.6 3.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger LprI PF07007.12 AMD22580.1 - 0.022 15.4 1.1 0.042 14.5 1.1 1.5 1 0 0 1 1 1 0 Lysozyme inhibitor LprI zf-RING_5 PF14634.6 AMD22580.1 - 0.06 13.3 2.4 0.18 11.8 2.4 1.8 1 0 0 1 1 1 0 zinc-RING finger domain DUF4083 PF13314.6 AMD22580.1 - 0.064 13.2 0.7 0.24 11.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) Acyltransf_C PF16076.5 AMD22580.1 - 0.073 13.2 0.0 0.24 11.5 0.0 1.9 1 0 0 1 1 1 0 Acyltransferase C-terminus Flagellin_N PF00669.20 AMD22580.1 - 0.13 12.3 0.2 0.24 11.5 0.2 1.3 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region zf-RING_2 PF13639.6 AMD22580.1 - 0.17 12.3 3.5 0.55 10.6 3.5 2.0 1 0 0 1 1 1 0 Ring finger domain CENP-H PF05837.12 AMD22580.1 - 2.2 8.7 6.7 1e+02 3.3 6.4 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Sgf11 PF08209.11 AMD22581.1 - 1e-17 63.3 3.5 1.4e-17 62.9 3.5 1.2 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) Sgf11_N PF18519.1 AMD22581.1 - 2.8e-17 62.0 1.2 5.2e-17 61.1 1.2 1.5 1 0 0 1 1 1 1 SAGA-associated factor 11 N-terminal domain Actin_micro PF17003.5 AMD22581.1 - 0.055 12.6 0.1 0.071 12.3 0.0 1.2 1 1 0 1 1 1 0 Putative actin-like family Glyco_hydro_57 PF03065.15 AMD22581.1 - 0.14 11.4 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Catalase PF00199.19 AMD22582.1 - 1e-182 607.5 0.3 1.6e-182 606.9 0.3 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 AMD22582.1 - 5.7e-12 45.7 0.1 2e-11 43.9 0.0 1.9 2 0 0 2 2 2 1 Catalase-related immune-responsive GST_C PF00043.25 AMD22583.1 - 2.9e-08 33.8 0.1 4.7e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AMD22583.1 - 9.2e-08 32.3 0.0 1.9e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 AMD22583.1 - 0.00065 20.1 0.0 0.0015 18.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 AMD22583.1 - 0.0087 16.2 0.1 0.014 15.6 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Cytochrom_C_2 PF01322.20 AMD22583.1 - 0.15 12.9 0.1 0.24 12.3 0.1 1.3 1 0 0 1 1 1 0 Cytochrome C' Anp1 PF03452.14 AMD22585.1 - 4.8e-105 350.7 0.0 5.8e-105 350.5 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 AMD22585.1 - 0.0017 18.2 0.0 0.0032 17.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 VASt PF16016.5 AMD22585.1 - 0.027 14.9 0.2 0.77 10.1 0.1 2.1 2 0 0 2 2 2 0 VAD1 Analog of StAR-related lipid transfer domain Alk_phosphatase PF00245.20 AMD22586.1 - 6.7e-108 361.3 0.2 7.8e-108 361.1 0.2 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 AMD22586.1 - 0.14 11.5 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 Metalloenzyme superfamily Arf PF00025.21 AMD22587.1 - 1.5e-43 148.3 0.1 1.9e-43 147.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 AMD22587.1 - 4.2e-13 49.2 0.3 2.5e-07 30.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 AMD22587.1 - 1.8e-12 47.2 0.0 2.2e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22587.1 - 6.4e-12 45.8 0.0 9.5e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 AMD22587.1 - 7.4e-09 35.3 0.0 9.5e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 AMD22587.1 - 2.9e-07 30.6 0.0 4.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AMD22587.1 - 1.7e-06 27.5 0.0 2.2e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AMD22587.1 - 4.4e-06 26.4 0.0 0.0001 21.9 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 AMD22587.1 - 0.023 14.7 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 AMD22587.1 - 0.026 14.4 0.0 1.6 8.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase GIT_SHD PF08518.11 AMD22588.1 - 2e-21 75.3 1.0 2.4e-09 36.7 0.0 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Pentapeptide_4 PF13599.6 AMD22588.1 - 3.1e-06 27.3 0.2 0.0018 18.4 0.0 3.7 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) GIT1_C PF12205.8 AMD22588.1 - 2.5e-05 24.4 0.2 2.5e-05 24.4 0.2 3.8 5 1 1 6 6 6 1 G protein-coupled receptor kinase-interacting protein 1 C term PilJ PF13675.6 AMD22588.1 - 0.59 10.2 5.1 0.36 10.9 2.0 2.4 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Herpes_UL6 PF01763.16 AMD22588.1 - 2.8 6.4 10.0 0.91 8.0 6.6 1.8 2 0 0 2 2 2 0 Herpesvirus UL6 like Herpes_BLRF2 PF05812.12 AMD22588.1 - 3.9 7.6 14.4 1.3 9.2 1.5 3.9 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein Leu_zip PF15294.6 AMD22588.1 - 6.9 6.1 25.7 0.052 13.1 13.6 3.1 3 1 0 3 3 3 0 Leucine zipper Ribonucleas_3_3 PF14622.6 AMD22589.1 - 2.3e-14 53.7 0.0 3.9e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like DEAD PF00270.29 AMD22590.1 - 9.2e-40 136.3 0.1 9.2e-40 136.3 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22590.1 - 3.6e-33 114.2 5.2 1.3e-29 102.8 0.0 3.3 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 AMD22590.1 - 1e-06 28.8 0.0 1e-06 28.8 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AMD22590.1 - 0.029 14.6 1.9 0.38 11.0 1.9 2.4 1 1 0 1 1 1 0 AAA domain CbiC PF02570.15 AMD22590.1 - 0.13 11.9 1.6 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 Precorrin-8X methylmutase ATP-synt_G PF04718.15 AMD22591.1 - 9.9e-30 103.3 0.3 1.2e-29 103.0 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit AbiGi PF10899.8 AMD22591.1 - 0.14 12.0 0.4 0.23 11.3 0.1 1.4 1 1 1 2 2 2 0 Putative abortive phage resistance protein AbiGi, antitoxin MCM PF00493.23 AMD22592.1 - 8.3e-103 342.3 0.0 1.5e-102 341.4 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AMD22592.1 - 6.9e-38 129.3 1.0 1.5e-37 128.3 1.0 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AMD22592.1 - 3e-29 101.3 2.6 9.8e-29 99.6 2.6 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AMD22592.1 - 4.5e-19 69.0 0.6 1.9e-18 66.9 0.6 2.2 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AMD22592.1 - 4.4e-06 26.2 0.0 0.00018 20.9 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AMD22592.1 - 6.2e-06 26.3 0.0 3.5e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AMD22592.1 - 0.00059 19.7 0.0 0.0076 16.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AMD22592.1 - 0.077 13.4 0.3 1.2 9.5 0.1 3.0 3 1 0 3 3 3 0 AAA ATPase domain Sigma54_activat PF00158.26 AMD22592.1 - 0.078 12.7 0.5 3 7.5 0.0 3.3 4 0 0 4 4 4 0 Sigma-54 interaction domain CDT1_C PF16679.5 AMD22592.1 - 0.21 12.0 3.0 0.91 10.0 0.1 2.8 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain EI24 PF07264.11 AMD22593.1 - 3.2e-05 24.3 12.3 4.9e-05 23.7 12.3 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) RICTOR_V PF14668.6 AMD22593.1 - 0.022 15.0 2.2 0.042 14.1 0.1 2.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 CAF1A PF12253.8 AMD22594.1 - 2.8e-20 72.2 12.7 2.8e-20 72.2 12.7 5.1 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A PXA PF02194.15 AMD22594.1 - 0.18 11.7 0.0 0.18 11.7 0.0 3.1 3 1 0 3 3 3 0 PXA domain PspB PF06667.12 AMD22594.1 - 1.4 9.0 0.0 1.4 9.0 0.0 3.2 2 1 1 3 3 3 0 Phage shock protein B Csm1_N PF18504.1 AMD22595.1 - 0.068 13.5 0.5 0.19 12.1 0.5 1.7 1 0 0 1 1 1 0 Csm1 N-terminal domain Mss4 PF04421.13 AMD22596.1 - 2.2e-16 59.7 0.0 2.9e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Mss4 protein eIF-6 PF01912.18 AMD22597.1 - 5.8e-82 273.9 1.2 7.2e-82 273.6 1.2 1.1 1 0 0 1 1 1 1 eIF-6 family RasGEF PF00617.19 AMD22598.1 - 1.1e-54 185.3 0.4 1.1e-54 185.3 0.4 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 AMD22598.1 - 3.8e-22 78.5 1.6 1.2e-21 76.9 0.2 2.8 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_9 PF14604.6 AMD22598.1 - 1.1e-11 44.4 0.3 5e-11 42.3 0.1 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 AMD22598.1 - 2.9e-11 42.8 0.0 7.9e-11 41.4 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AMD22598.1 - 1.7e-06 27.6 0.1 4.5e-06 26.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain DUF4904 PF16247.5 AMD22598.1 - 0.17 11.7 0.3 12 5.7 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4904) CYSTM PF12734.7 AMD22599.1 - 0.00014 22.1 31.9 0.0056 17.0 31.9 2.1 1 1 0 1 1 1 1 Cysteine-rich TM module stress tolerance GRIP PF01465.20 AMD22600.1 - 3.1e-12 46.2 0.1 8.3e-12 44.8 0.1 1.8 1 0 0 1 1 1 1 GRIP domain Spc7 PF08317.11 AMD22600.1 - 1.4e-05 24.2 117.7 0.018 13.9 10.0 6.1 2 2 4 6 6 6 5 Spc7 kinetochore protein ATG16 PF08614.11 AMD22600.1 - 0.00041 20.6 113.7 0.1 12.8 19.0 7.1 1 1 6 7 7 7 3 Autophagy protein 16 (ATG16) MAD PF05557.13 AMD22600.1 - 0.0011 17.5 23.6 0.0011 17.5 23.6 4.3 2 1 1 4 4 4 3 Mitotic checkpoint protein Tropomyosin_1 PF12718.7 AMD22600.1 - 0.0015 18.7 14.5 0.0015 18.7 14.5 7.7 3 2 4 7 7 7 2 Tropomyosin like DUF1192 PF06698.11 AMD22600.1 - 0.0046 17.0 17.8 1.8 8.7 0.3 6.1 6 0 0 6 6 6 2 Protein of unknown function (DUF1192) DUF4407 PF14362.6 AMD22600.1 - 0.0048 16.3 76.3 0.48 9.7 20.7 6.1 1 1 4 5 5 5 4 Domain of unknown function (DUF4407) JIP_LZII PF16471.5 AMD22600.1 - 0.0088 16.2 0.5 0.0088 16.2 0.5 10.8 5 2 5 11 11 10 1 JNK-interacting protein leucine zipper II IFT20 PF14931.6 AMD22600.1 - 0.0096 16.1 12.4 0.0096 16.1 12.4 8.3 2 2 4 8 8 8 1 Intraflagellar transport complex B, subunit 20 Jnk-SapK_ap_N PF09744.9 AMD22600.1 - 0.013 15.8 19.8 0.013 15.8 19.8 8.1 2 2 6 8 8 8 0 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 AMD22600.1 - 0.036 14.1 119.9 0.093 12.8 8.2 8.5 3 2 2 7 7 5 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 AMD22600.1 - 0.12 12.4 69.8 0.033 14.2 3.5 8.3 3 3 5 9 9 9 0 Protein of unknown function (DUF1664) HOOK PF05622.12 AMD22600.1 - 0.24 9.5 113.4 0.0034 15.6 23.2 4.1 2 1 2 4 4 4 0 HOOK protein TolA_bind_tri PF16331.5 AMD22600.1 - 0.26 11.4 0.1 0.26 11.4 0.1 9.4 7 2 2 9 9 9 0 TolA binding protein trimerisation AAA_13 PF13166.6 AMD22600.1 - 0.56 8.8 101.8 1.9 7.0 23.9 4.2 2 1 1 3 3 3 0 AAA domain SHE3 PF17078.5 AMD22600.1 - 1.1 8.9 113.8 0.037 13.7 14.4 7.0 3 1 4 7 7 7 0 SWI5-dependent HO expression protein 3 DPM3 PF08285.11 AMD22600.1 - 3.5 7.9 5.4 26 5.1 0.1 3.9 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Fib_alpha PF08702.10 AMD22600.1 - 3.6 7.8 97.5 0.033 14.4 12.7 8.2 3 2 5 10 10 9 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 AMD22600.1 - 6.8 7.1 107.0 1.5 9.2 22.7 6.5 1 1 5 6 6 5 0 Fez1 Polysacc_deac_1 PF01522.21 AMD22601.1 - 3.8e-25 88.2 0.0 6.5e-25 87.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase V_cholerae_RfbT PF05575.11 AMD22601.1 - 0.057 12.7 0.1 0.093 12.0 0.1 1.2 1 0 0 1 1 1 0 Vibrio cholerae RfbT protein UQ_con PF00179.26 AMD22603.1 - 1e-34 119.2 0.0 1.6e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 AMD22603.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 UEV domain PI3_PI4_kinase PF00454.27 AMD22605.1 - 2.7e-42 145.3 0.4 8.9e-40 137.1 0.0 3.0 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 AMD22605.1 - 4.9e-26 91.3 0.2 4.9e-26 91.3 0.2 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Imm30 PF15565.6 AMD22605.1 - 0.078 13.1 0.1 0.37 10.9 0.1 2.2 1 0 0 1 1 1 0 Immunity protein 30 Aconitase PF00330.20 AMD22606.1 - 2.8e-151 504.6 0.0 3.5e-151 504.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AMD22606.1 - 6.4e-45 152.7 0.0 1.3e-44 151.7 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain tRNA-synt_2 PF00152.20 AMD22607.1 - 5.8e-81 272.0 0.2 1e-80 271.2 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AMD22607.1 - 2e-05 24.5 0.4 3.7e-05 23.6 0.4 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain zf-C2H2 PF00096.26 AMD22608.1 - 4e-08 33.3 14.7 0.00019 21.7 2.3 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22608.1 - 1.1e-06 28.9 9.5 0.005 17.6 1.5 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AMD22608.1 - 2.4e-05 24.5 5.7 0.0038 17.6 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 AMD22608.1 - 2.5e-05 24.5 9.0 0.00011 22.4 0.1 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AMD22608.1 - 0.0063 16.8 6.1 0.3 11.4 0.0 2.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 AMD22608.1 - 0.16 11.8 0.1 0.16 11.8 0.1 3.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Ogr_Delta PF04606.12 AMD22608.1 - 0.21 11.6 2.6 0.8 9.7 2.6 2.1 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger Zn_ribbon_SprT PF17283.2 AMD22608.1 - 0.26 11.3 5.4 1 9.3 0.8 2.4 2 0 0 2 2 2 0 SprT-like zinc ribbon domain FOXP-CC PF16159.5 AMD22608.1 - 0.27 11.9 0.1 0.27 11.9 0.1 2.0 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 AMD22608.1 - 0.42 11.0 3.0 1.9 8.9 0.2 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 AMD22608.1 - 0.51 10.5 3.6 6 7.1 0.6 2.4 2 0 0 2 2 2 0 Zinc ribbon domain CHCH PF06747.13 AMD22609.1 - 0.013 15.6 0.2 0.025 14.7 0.2 1.5 1 1 0 1 1 1 0 CHCH domain Pet191_N PF10203.9 AMD22609.1 - 0.13 12.6 2.1 0.36 11.2 2.1 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 AMD22609.1 - 0.14 12.5 1.0 2.7 8.4 0.1 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) zf-C2H2 PF00096.26 AMD22610.1 - 3.7e-10 39.7 8.3 0.0001 22.5 0.1 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22610.1 - 3e-07 30.7 7.9 0.0017 19.1 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AMD22610.1 - 0.028 14.8 3.2 0.047 14.1 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AMD22610.1 - 0.056 13.7 0.5 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 AMD22610.1 - 0.12 12.9 1.2 0.12 12.9 1.2 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_2 PF12756.7 AMD22610.1 - 0.67 10.3 0.1 0.67 10.3 0.1 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 AMD22610.1 - 5.6 7.1 7.0 1.7 8.7 0.1 2.4 1 1 1 2 2 2 0 BED zinc finger Pkinase PF00069.25 AMD22611.1 - 4.2e-44 150.9 0.0 2e-43 148.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22611.1 - 7.6e-20 71.3 0.0 3.2e-19 69.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD22611.1 - 0.024 13.4 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 AMD22611.1 - 0.037 13.4 0.1 0.27 10.5 0.0 2.3 2 1 0 2 2 2 0 Kinase-like Kdo PF06293.14 AMD22611.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1611 PF07755.11 AMD22611.1 - 0.22 10.8 0.0 0.4 9.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain Nucleoporin_FG PF13634.6 AMD22613.1 - 8.2e-18 65.0 110.0 1.1e-07 32.6 27.6 3.7 2 1 2 4 4 4 3 Nucleoporin FG repeat region Tweety PF04906.13 AMD22613.1 - 0.00093 18.0 0.3 0.00093 18.0 0.3 2.9 4 0 0 4 4 4 1 Tweety DUF1664 PF07889.12 AMD22613.1 - 0.061 13.4 3.8 9.4 6.3 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 AMD22613.1 - 0.97 9.8 5.2 10 6.5 0.0 3.7 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lipase_chap PF03280.14 AMD22613.1 - 1.8 8.5 7.2 0.62 10.0 1.2 2.6 3 0 0 3 3 3 0 Proteobacterial lipase chaperone protein DUF713 PF05218.14 AMD22613.1 - 1.9 8.2 7.5 28 4.4 7.6 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF713) DUF4600 PF15372.6 AMD22613.1 - 2.5 8.6 5.2 2.7 8.4 1.3 2.5 2 2 0 2 2 2 0 Domain of unknown function (DUF4600) KxDL PF10241.9 AMD22613.1 - 2.6 8.4 9.7 7.9 6.8 2.4 3.5 4 0 0 4 4 4 0 Uncharacterized conserved protein XRN_N PF03159.18 AMD22614.1 - 1.4e-94 316.0 0.1 1.4e-94 316.0 0.1 1.8 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 AMD22614.1 - 1.1e-82 278.3 7.8 1.1e-82 278.3 7.8 2.5 2 1 0 2 2 2 1 Xrn1 helical domain XRN1_D1 PF18332.1 AMD22614.1 - 2.1e-60 203.8 5.0 2.2e-60 203.7 0.1 2.5 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 AMD22614.1 - 6.7e-30 103.1 0.0 2.5e-29 101.3 0.0 2.1 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain Xrn1_D3 PF18194.1 AMD22614.1 - 2.6e-18 65.9 0.4 8.4e-18 64.2 0.4 2.0 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 SH3_12 PF18129.1 AMD22614.1 - 3.1e-18 65.6 0.1 6.2e-18 64.7 0.1 1.5 1 0 0 1 1 1 1 Xrn1 SH3-like domain Bud13 PF09736.9 AMD22615.1 - 1.4e-23 83.9 4.6 4.3e-21 75.8 0.5 3.3 3 1 0 3 3 3 2 Pre-mRNA-splicing factor of RES complex SAE2 PF08573.10 AMD22616.1 - 0.048 14.8 0.1 0.048 14.8 0.1 2.5 3 0 0 3 3 3 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Mito_carr PF00153.27 AMD22617.1 - 2.9e-73 241.9 0.5 1.2e-24 86.1 0.0 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AMD22617.1 - 0.039 13.1 0.2 4.7 6.3 0.0 3.1 2 1 0 3 3 3 0 Gammaproteobacterial serine protease EF-hand_8 PF13833.6 AMD22617.1 - 0.13 12.1 0.3 0.87 9.5 0.1 2.6 3 0 0 3 3 3 0 EF-hand domain pair zf-C2H2 PF00096.26 AMD22618.1 - 2.4e-11 43.4 9.3 1.3e-05 25.4 2.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22618.1 - 2.2e-08 34.2 6.2 0.0022 18.6 0.3 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AMD22618.1 - 6.7e-07 29.4 7.1 0.074 13.5 0.2 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 AMD22618.1 - 5.8e-05 23.0 4.1 0.0078 16.2 0.1 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AMD22618.1 - 9.3e-05 22.7 6.7 0.017 15.5 0.2 2.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 AMD22618.1 - 0.028 14.2 2.9 2.6 7.9 0.3 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type TRAF6_Z2 PF18048.1 AMD22618.1 - 0.04 14.0 1.9 0.054 13.6 0.1 2.0 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-H2C2_5 PF13909.6 AMD22618.1 - 0.083 12.7 2.4 0.083 12.7 2.4 2.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_9 PF16293.5 AMD22618.1 - 0.17 11.7 1.0 0.63 9.9 0.1 2.1 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 AMD22618.1 - 0.22 12.0 0.4 0.48 10.9 0.1 1.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2 PF00096.26 AMD22619.1 - 3.5e-07 30.3 10.5 0.00017 21.9 1.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD22619.1 - 0.00013 22.2 11.1 0.11 13.0 0.9 3.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD22619.1 - 0.0013 19.4 14.1 0.003 18.2 1.1 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 AMD22619.1 - 0.012 16.0 0.1 0.041 14.4 0.1 2.0 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-met PF12874.7 AMD22619.1 - 0.028 14.8 0.3 0.028 14.8 0.3 2.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AMD22619.1 - 0.11 12.6 6.1 1.1 9.3 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger FOXP-CC PF16159.5 AMD22619.1 - 0.13 12.9 0.1 0.13 12.9 0.1 2.2 3 0 0 3 3 3 0 FOXP coiled-coil domain FMN_red PF03358.15 AMD22620.1 - 1.9e-05 24.4 0.0 2.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AMD22620.1 - 0.047 13.4 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin-like fold MRG PF05712.13 AMD22621.1 - 2.1e-42 144.7 0.1 3.8e-42 143.9 0.0 1.4 2 0 0 2 2 2 1 MRG Tudor-knot PF11717.8 AMD22621.1 - 1.6e-06 27.9 0.3 3.7e-06 26.7 0.3 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Pkinase PF00069.25 AMD22622.1 - 6.8e-18 65.0 0.0 5.5e-17 62.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22622.1 - 4.9e-10 39.1 0.0 7e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AMD22622.1 - 4.4e-06 25.7 1.1 8.9e-06 24.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 AMD22622.1 - 0.03 14.2 0.0 1.6 8.6 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family KHA PF11834.8 AMD22622.1 - 0.064 13.4 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel tRNA-synt_1 PF00133.22 AMD22626.1 - 2.4e-232 772.5 0.0 3.6e-232 771.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AMD22626.1 - 3.1e-25 88.9 0.3 1.3e-24 86.9 0.1 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AMD22626.1 - 7.4e-15 54.6 2.3 3.9e-05 22.6 0.4 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 AMD22626.1 - 6.1e-05 22.5 0.3 0.0011 18.4 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain HSP70 PF00012.20 AMD22627.1 - 2.6e-261 868.1 7.1 3e-261 867.9 7.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AMD22627.1 - 1.3e-16 60.3 0.0 1.4e-15 57.0 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 AMD22627.1 - 0.00019 21.2 0.0 0.00064 19.5 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Golgin_A5 PF09787.9 AMD22627.1 - 0.024 14.1 10.8 0.016 14.7 6.4 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 DDR PF08841.10 AMD22627.1 - 0.026 13.5 0.3 0.62 9.0 0.1 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 AMD22627.1 - 0.043 13.3 0.0 7.2 6.0 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 AMD22627.1 - 0.054 12.8 0.2 0.18 11.0 0.2 1.9 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase SWI-SNF_Ssr4 PF08549.10 AMD22627.1 - 0.54 8.8 9.1 0.33 9.5 0.1 2.1 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) AAR2 PF05282.11 AMD22628.1 - 9.7e-36 123.9 3.5 1.3e-35 123.5 3.5 1.1 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S8e PF01201.22 AMD22629.1 - 3e-57 192.6 2.0 3.5e-57 192.4 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.13 AMD22630.1 - 6.3e-22 77.1 0.8 8.1e-22 76.7 0.8 1.1 1 0 0 1 1 1 1 CSL zinc finger Terminase_GpA PF05876.12 AMD22630.1 - 0.15 10.6 0.1 0.16 10.5 0.1 1.0 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) ADH_zinc_N_2 PF13602.6 AMD22631.1 - 5.7e-13 50.1 0.0 1.1e-12 49.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CDC45 PF02724.14 AMD22631.1 - 3.5 5.8 5.7 4.9 5.3 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 AMD22631.1 - 7.1 5.7 12.8 9.6 5.2 12.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) UQ_con PF00179.26 AMD22632.1 - 2.4e-22 79.1 0.0 4.6e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme EMP24_GP25L PF01105.24 AMD22632.1 - 0.052 13.5 0.1 0.067 13.1 0.1 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Pribosyltran_N PF13793.6 AMD22633.1 - 1.1e-44 151.1 0.6 7.2e-43 145.2 0.1 2.5 2 1 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 AMD22633.1 - 2e-36 125.8 2.6 9.9e-30 103.9 2.5 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 AMD22633.1 - 8.6e-16 57.8 0.3 1.8e-15 56.8 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AMD22633.1 - 0.0085 15.6 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase UCH PF00443.29 AMD22634.1 - 3.7e-61 206.9 0.2 7.8e-61 205.8 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD22634.1 - 1.8e-24 86.9 3.7 4.8e-19 69.1 0.7 2.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 AMD22634.1 - 0.011 15.2 2.6 0.58 9.6 3.2 3.0 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Actin_micro PF17003.5 AMD22634.1 - 0.082 12.1 1.8 0.15 11.2 0.8 1.8 1 1 1 2 2 2 0 Putative actin-like family Fungal_trans PF04082.18 AMD22635.1 - 5.3e-18 65.0 1.7 1.1e-17 64.0 1.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD22635.1 - 2.2e-09 37.3 10.9 3.8e-09 36.5 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AhpC-TSA PF00578.21 AMD22636.1 - 1.3e-29 102.6 0.0 1.9e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 AMD22636.1 - 5.9e-14 51.6 0.2 1e-13 50.8 0.2 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 AMD22636.1 - 9.9e-09 35.1 0.0 1.5e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Redoxin Kinesin PF00225.23 AMD22637.1 - 3e-106 355.1 3.1 3e-106 355.1 3.1 2.3 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 AMD22637.1 - 2.5e-26 92.4 0.6 2.5e-26 92.4 0.6 4.1 3 1 0 3 3 3 1 Microtubule binding DUF5063 PF16702.5 AMD22637.1 - 0.035 14.5 3.0 0.25 11.7 0.1 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF5063) ResIII PF04851.15 AMD22637.1 - 0.13 12.3 0.0 0.13 12.3 0.0 3.0 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit SRA1 PF07304.11 AMD22637.1 - 0.16 11.7 0.0 0.16 11.7 0.0 3.3 5 0 0 5 5 5 0 Steroid receptor RNA activator (SRA1) DUF3482 PF11981.8 AMD22637.1 - 0.63 9.4 4.4 1.6 8.0 4.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Apolipoprotein PF01442.18 AMD22637.1 - 1.2 9.0 18.0 0.82 9.5 7.3 4.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Sel1 PF08238.12 AMD22638.1 - 1e-46 156.3 11.9 1.5e-07 31.9 0.4 7.6 7 0 0 7 7 7 7 Sel1 repeat APC1_C PF18122.1 AMD22638.1 - 0.027 14.4 0.1 0.061 13.3 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain Rad51 PF08423.11 AMD22639.1 - 3.3e-129 429.6 0.0 4.6e-129 429.1 0.0 1.2 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AMD22639.1 - 4.8e-12 45.9 0.0 7e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AMD22639.1 - 9.5e-10 38.4 0.0 1.5e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 AMD22639.1 - 4.2e-09 36.9 0.1 9e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 AMD22639.1 - 2.7e-05 23.6 0.1 5.9e-05 22.5 0.1 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 AMD22639.1 - 0.0029 17.0 0.1 0.016 14.6 0.0 1.9 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 AMD22639.1 - 0.068 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain HHH PF00633.23 AMD22639.1 - 0.099 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA_22 PF13401.6 AMD22639.1 - 0.15 12.3 0.1 0.43 10.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 AMD22639.1 - 0.33 11.0 1.3 0.78 9.8 1.3 1.6 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain Sec7 PF01369.20 AMD22640.1 - 3.6e-11 43.1 0.6 7.2e-11 42.1 0.6 1.4 1 0 0 1 1 1 1 Sec7 domain Proteasome PF00227.26 AMD22641.1 - 4.4e-39 134.0 0.0 5.2e-39 133.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Cmc1 PF08583.10 AMD22642.1 - 3.2e-16 59.1 11.1 4.9e-16 58.5 11.1 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 AMD22642.1 - 0.059 13.5 2.8 0.85 9.8 0.2 2.3 2 0 0 2 2 2 0 CHCH domain DUF3576 PF12100.8 AMD22642.1 - 0.06 13.5 0.4 0.081 13.0 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3576) RICTOR_N PF14664.6 AMD22644.1 - 3.8e-90 302.6 13.8 3.8e-90 302.6 13.8 2.0 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 AMD22644.1 - 2e-29 101.4 10.3 1.8e-28 98.3 0.1 5.9 6 1 0 6 6 6 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 AMD22644.1 - 8.3e-26 90.0 0.3 2.3e-24 85.4 0.0 3.6 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 AMD22644.1 - 1.4e-25 89.7 5.2 1.8e-24 86.2 0.1 4.4 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT PF02985.22 AMD22644.1 - 0.023 14.9 1.2 27 5.4 0.0 5.4 6 0 0 6 6 6 0 HEAT repeat Vac14_Fab1_bd PF12755.7 AMD22644.1 - 0.055 14.1 0.2 0.32 11.6 0.2 2.4 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region Corona_NS4 PF03905.13 AMD22644.1 - 0.095 12.7 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Coronavirus non-structural protein NS4 IES5 PF17335.2 AMD22645.1 - 4.5e-36 123.6 3.0 5.1e-36 123.4 3.0 1.0 1 0 0 1 1 1 1 Ino80 complex subunit 5 JIP_LZII PF16471.5 AMD22645.1 - 0.15 12.3 3.7 0.38 11.0 1.2 2.2 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II V_ATPase_I PF01496.19 AMD22645.1 - 0.2 9.5 0.3 0.22 9.4 0.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Meth_synt_2 PF01717.18 AMD22646.1 - 5e-149 495.9 0.0 3.5e-144 480.0 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 AMD22646.1 - 5.7e-115 384.1 0.1 8.1e-100 334.3 0.0 3.2 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain UPF0102 PF02021.17 AMD22646.1 - 0.12 12.6 0.1 0.31 11.3 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0102 URO-D PF01208.17 AMD22646.1 - 0.19 10.8 0.0 11 5.0 0.0 2.5 3 0 0 3 3 3 0 Uroporphyrinogen decarboxylase (URO-D) SEP PF08059.13 AMD22647.1 - 1.4e-21 76.8 0.2 1.4e-21 76.8 0.2 2.1 3 0 0 3 3 3 1 SEP domain UBX PF00789.20 AMD22647.1 - 8.2e-15 54.8 0.1 1.5e-14 54.0 0.1 1.4 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 AMD22647.1 - 6.6e-12 45.0 0.4 1.6e-11 43.8 0.4 1.7 1 0 0 1 1 1 1 UBA-like domain TFIIE-A_C PF11521.8 AMD22647.1 - 3.6 7.9 6.8 0.69 10.2 1.2 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha PTH2 PF01981.16 AMD22648.1 - 1.3e-41 141.5 0.0 2.3e-41 140.8 0.0 1.4 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Sigma70_r4 PF04545.16 AMD22648.1 - 0.13 11.9 0.1 0.36 10.4 0.2 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 Chorismate_bind PF00425.18 AMD22649.1 - 1.7e-92 309.6 0.0 5.4e-92 308.0 0.0 1.7 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 AMD22649.1 - 9.7e-27 93.9 0.0 2e-22 79.9 0.0 3.7 3 1 0 3 3 3 2 Anthranilate synthase component I, N terminal region PP2C PF00481.21 AMD22650.1 - 6.2e-80 268.5 0.0 8e-80 268.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3873 PF12989.7 AMD22650.1 - 0.24 11.8 1.2 0.85 10.0 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) TatD_DNase PF01026.21 AMD22651.1 - 4.6e-38 131.1 0.0 1.1e-37 129.8 0.0 1.5 1 1 0 1 1 1 1 TatD related DNase Myb_DNA-binding PF00249.31 AMD22652.1 - 1.2e-11 44.6 4.9 3.9e-11 42.9 0.3 2.7 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD22652.1 - 8.8e-10 38.7 2.0 7e-09 35.8 0.3 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain MOZ_SAS PF01853.18 AMD22653.1 - 3.3e-74 248.4 0.2 6e-74 247.6 0.2 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 AMD22653.1 - 2.5e-18 65.4 10.3 2.5e-18 65.4 10.3 1.8 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 AMD22653.1 - 0.0036 17.7 0.0 0.0084 16.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GCIP PF13324.6 AMD22653.1 - 0.19 11.3 7.1 0.37 10.4 7.1 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting CDC45 PF02724.14 AMD22653.1 - 3.1 6.0 13.9 5.2 5.3 13.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 AMD22653.1 - 4.4 5.4 17.2 6.4 4.9 17.2 1.2 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 AMD22653.1 - 5.5 6.6 25.7 15 5.2 25.6 1.8 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 AMD22653.1 - 7 6.0 14.8 13 5.1 14.8 1.4 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 AMD22653.1 - 7.4 6.1 22.1 0.35 10.4 15.5 2.0 2 0 0 2 2 2 0 PPP4R2 RRM_1 PF00076.22 AMD22654.1 - 5.2e-07 29.4 0.1 1.1e-06 28.4 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.12 AMD22654.1 - 0.079 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif 2 Band_3_cyto PF07565.13 AMD22654.1 - 1.7 8.4 8.0 0.17 11.6 3.3 1.6 2 0 0 2 2 2 0 Band 3 cytoplasmic domain EPL1 PF10513.9 AMD22654.1 - 5.5 7.4 9.6 1.8 8.9 4.6 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Brr6_like_C_C PF10104.9 AMD22655.1 - 4.3e-37 126.9 0.3 5.1e-37 126.6 0.3 1.0 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain RAI1 PF08652.11 AMD22656.1 - 2.2e-26 91.8 0.3 4.5e-26 90.8 0.3 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease tRNA-synt_1c PF00749.21 AMD22657.1 - 2.2e-117 391.5 0.0 2.9e-117 391.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 AMD22657.1 - 4.3e-39 134.2 0.1 9.2e-39 133.1 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GluRS_N PF18466.1 AMD22657.1 - 7.9e-11 42.2 0.9 7.9e-11 42.2 0.9 2.6 2 0 0 2 2 2 1 Glutamate--tRNA ligase N-terminal domain GST_C_2 PF13410.6 AMD22657.1 - 0.00016 21.6 0.0 0.00043 20.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 AMD22657.1 - 0.0043 17.2 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF155 PF02582.14 AMD22658.1 - 1.2e-52 178.5 0.0 2e-52 177.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 SecG PF03840.14 AMD22658.1 - 0.15 12.2 0.7 0.32 11.1 0.7 1.5 1 0 0 1 1 1 0 Preprotein translocase SecG subunit Plus-3 PF03126.18 AMD22659.1 - 2.2e-27 95.7 1.0 6.9e-27 94.1 0.0 2.3 2 0 0 2 2 2 1 Plus-3 domain A_deamin PF02137.18 AMD22660.1 - 1.6e-29 103.4 0.0 2.3e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Ank_5 PF13857.6 AMD22661.1 - 2.8e-07 30.7 0.0 0.00022 21.5 0.0 2.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 AMD22661.1 - 7.7e-07 28.9 0.2 0.032 14.8 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 AMD22661.1 - 6.1e-06 26.4 0.2 0.024 15.1 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 AMD22661.1 - 3.2e-05 24.4 0.5 0.055 14.1 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AMD22661.1 - 7e-05 23.3 0.0 0.00022 21.8 0.0 1.8 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) IBN_N PF03810.19 AMD22662.1 - 6.3e-06 26.0 0.0 9.1e-05 22.3 0.0 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 AMD22662.1 - 0.28 11.2 0.1 0.28 11.2 0.1 5.1 6 1 1 7 7 7 0 Exportin 1-like protein Palm_thioest PF02089.15 AMD22663.1 - 0.24 11.2 1.1 0.32 10.8 0.3 1.6 2 0 0 2 2 2 0 Palmitoyl protein thioesterase QRPTase_C PF01729.19 AMD22664.1 - 1.2e-57 194.4 0.0 1.5e-57 194.1 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 AMD22664.1 - 3e-17 62.4 0.0 8.8e-17 60.9 0.0 1.8 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain ANAPC10 PF03256.16 AMD22665.1 - 1.8e-43 148.3 0.0 2.3e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 AMD22665.1 - 6.8e-05 23.0 0.0 0.00014 22.0 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain Cse1 PF08506.10 AMD22666.1 - 5.5e-170 565.1 9.2 1.1e-169 564.1 9.2 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 AMD22666.1 - 1.4e-111 373.2 4.2 1.4e-111 373.2 4.2 1.8 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 AMD22666.1 - 4.5e-15 55.3 0.2 1.1e-13 50.9 0.0 3.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 AMD22666.1 - 0.04 14.0 2.7 0.45 10.6 0.0 4.2 4 1 0 4 4 4 0 Exportin 1-like protein RPAP3_C PF13877.6 AMD22666.1 - 0.41 11.2 2.2 10 6.7 0.0 4.0 3 1 1 4 4 4 0 Potential Monad-binding region of RPAP3 CBFB_NFYA PF02045.15 AMD22667.1 - 1.9e-27 95.6 7.9 4.2e-27 94.5 7.9 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B CENP-T_C PF15511.6 AMD22668.1 - 3.7e-05 23.8 0.0 6.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold GIDA PF01134.22 AMD22669.1 - 2e-157 524.3 0.0 2.5e-157 524.0 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 AMD22669.1 - 3.3e-66 223.5 0.0 5.2e-66 222.8 0.0 1.3 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 AMD22669.1 - 8.3e-05 22.0 2.3 0.00017 21.0 1.0 2.0 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AMD22669.1 - 0.00013 21.5 0.5 0.00026 20.5 0.5 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase PA_decarbox PF05870.11 AMD22669.1 - 0.074 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) FAD_binding_2 PF00890.24 AMD22669.1 - 0.087 11.9 6.3 0.035 13.2 3.6 1.7 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 AMD22669.1 - 0.16 11.2 0.2 0.3 10.3 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AMD22669.1 - 0.34 9.6 2.8 9.7 4.8 1.9 2.3 2 0 0 2 2 2 0 HI0933-like protein GARS_A PF01071.19 AMD22670.1 - 5.4e-81 271.0 0.0 1e-80 270.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 AMD22670.1 - 9.3e-35 120.1 0.0 2.4e-33 115.4 0.0 2.6 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 AMD22670.1 - 2.1e-33 114.9 0.2 1e-32 112.8 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 AMD22670.1 - 3.4e-27 94.6 0.3 8.7e-27 93.2 0.3 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 AMD22670.1 - 1.9e-17 63.7 1.9 3.8e-16 59.5 2.3 2.6 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 AMD22670.1 - 1.6e-06 27.8 0.0 3.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AMD22670.1 - 4.8e-06 26.2 0.0 8.4e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 AMD22670.1 - 2.2e-05 24.5 0.1 6.6e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.10 AMD22670.1 - 0.029 13.9 0.0 0.081 12.5 0.0 1.7 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_4 PF13535.6 AMD22670.1 - 0.082 12.5 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp domain Mito_carr PF00153.27 AMD22671.1 - 2.6e-39 133.0 4.7 1.2e-17 63.6 0.1 4.2 3 2 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AMD22671.1 - 0.018 14.2 0.1 8.6 5.4 0.0 3.1 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Peptidase_M20 PF01546.28 AMD22672.1 - 5.9e-29 101.3 0.0 8.6e-29 100.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AMD22672.1 - 8.7e-11 41.7 0.0 1.7e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 AMD22672.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Sec15 PF04091.12 AMD22673.1 - 7.6e-101 337.7 12.4 7.6e-101 337.7 12.4 1.9 3 0 0 3 3 3 1 Exocyst complex subunit Sec15-like THUMP PF02926.17 AMD22674.1 - 1.1e-21 77.5 0.7 2.3e-21 76.4 0.4 1.8 1 1 0 1 1 1 1 THUMP domain DUF1077 PF06417.12 AMD22675.1 - 1.7e-42 144.1 3.0 2.2e-42 143.8 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) SCAMP PF04144.13 AMD22675.1 - 0.017 15.4 0.8 0.021 15.1 0.8 1.1 1 0 0 1 1 1 0 SCAMP family Adaptin_binding PF10199.9 AMD22676.1 - 0.0009 19.8 0.4 0.038 14.6 0.1 2.2 1 1 1 2 2 2 2 Alpha and gamma adaptin binding protein p34 DUF1442 PF07279.11 AMD22676.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) DnaJ PF00226.31 AMD22678.1 - 2.1e-12 46.9 2.0 8.2e-12 45.1 1.8 2.0 2 0 0 2 2 2 1 DnaJ domain DUF573 PF04504.14 AMD22678.1 - 0.085 13.5 2.1 0.22 12.2 2.1 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF573 SAPS PF04499.15 AMD22679.1 - 1.9e-172 574.5 5.5 1.9e-172 574.5 5.5 2.1 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein MethyltransfD12 PF02086.15 AMD22680.1 - 0.24 11.1 6.8 1.2 8.8 0.2 2.3 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase DUF883 PF05957.13 AMD22680.1 - 2.7 8.7 6.0 3.6 8.3 0.7 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) AdoHcyase PF05221.17 AMD22681.1 - 5.1e-131 436.3 0.0 5.2e-74 249.1 0.3 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 AMD22681.1 - 1.8e-85 285.0 3.2 2.8e-85 284.3 3.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 AMD22681.1 - 3.2e-06 26.6 0.1 6.3e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AMD22681.1 - 0.00017 21.2 0.2 0.0003 20.4 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 AMD22681.1 - 0.00046 20.4 0.1 0.00089 19.5 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain PALP PF00291.25 AMD22681.1 - 0.083 12.3 1.4 0.22 10.9 0.7 1.8 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme SPRY PF00622.28 AMD22682.1 - 1.8e-24 86.2 0.1 5.1e-24 84.7 0.1 1.8 2 0 0 2 2 2 1 SPRY domain CLTH PF10607.9 AMD22682.1 - 6.5e-10 39.1 2.4 1.2e-09 38.2 2.4 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 AMD22682.1 - 0.038 14.0 0.0 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 LisH Ost5 PF05251.12 AMD22683.1 - 1.9e-14 53.7 4.2 2.2e-14 53.5 4.2 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 COX4 PF02936.14 AMD22684.1 - 4.6e-10 39.7 0.1 5.8e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV RNase_J_C PF17770.1 AMD22684.1 - 0.15 13.1 0.0 4.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain PMSR PF01625.21 AMD22685.1 - 1.1e-50 171.8 0.2 1.3e-50 171.6 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase XPG_I PF00867.18 AMD22686.1 - 9e-23 80.5 0.0 2.1e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 AMD22686.1 - 3.2e-05 24.3 0.0 0.00012 22.4 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain DUF5638 PF18688.1 AMD22686.1 - 0.044 14.1 0.0 14 6.1 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5638) GATA PF00320.27 AMD22687.1 - 7.1e-16 57.5 2.4 1.5e-15 56.5 2.4 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 AMD22687.1 - 0.1 12.1 0.3 0.2 11.2 0.3 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Img2 PF05046.14 AMD22688.1 - 1.7e-19 69.9 0.1 3.2e-19 69.0 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Glyco_transf_22 PF03901.17 AMD22689.1 - 7e-35 121.0 11.3 9.3e-35 120.6 11.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family cobW PF02492.19 AMD22690.1 - 7.4e-44 149.4 0.1 1.1e-43 148.8 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 AMD22690.1 - 0.0016 18.2 0.0 0.0042 16.8 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain GTP_EFTU PF00009.27 AMD22690.1 - 0.0045 16.5 0.0 2.6 7.5 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 AMD22690.1 - 0.0054 17.2 0.0 0.014 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD22690.1 - 0.011 16.3 0.1 0.18 12.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AMD22690.1 - 0.045 13.7 0.2 2.6 7.9 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase CobW_C PF07683.14 AMD22690.1 - 0.06 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain NACHT PF05729.12 AMD22690.1 - 0.12 12.2 0.2 0.56 10.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Pro_isomerase PF00160.21 AMD22691.1 - 4e-29 101.9 0.0 6.9e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lipase_3 PF01764.25 AMD22692.1 - 5.2e-08 32.8 0.0 1.1e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Phos_pyr_kin PF08543.12 AMD22693.1 - 3.5e-09 36.4 0.0 4.7e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase ANAPC4_WD40 PF12894.7 AMD22694.1 - 1.5e-07 31.6 0.0 0.0048 17.2 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AMD22694.1 - 1.1e-05 26.0 0.2 0.68 10.9 0.0 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat Pr_beta_C PF12465.8 AMD22694.1 - 0.14 11.6 1.2 0.55 9.7 1.2 2.1 1 0 0 1 1 1 0 Proteasome beta subunits C terminal DUF2096 PF09869.9 AMD22694.1 - 0.26 11.4 3.7 0.22 11.6 1.4 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) zf-C3HC4_2 PF13923.6 AMD22695.1 - 3.7e-12 45.9 7.7 3.7e-12 45.9 7.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD22695.1 - 9.4e-10 38.2 12.4 3.2e-09 36.5 8.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 AMD22695.1 - 1.2e-08 34.5 0.0 4.2e-08 32.7 0.0 2.1 1 0 0 1 1 1 1 SAP domain zf-C3HC4_3 PF13920.6 AMD22695.1 - 1.9e-08 34.0 10.4 3.2e-08 33.3 5.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 AMD22695.1 - 3.9e-08 33.0 4.2 3.9e-08 33.0 4.2 2.1 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 AMD22695.1 - 1.5e-07 31.4 17.1 3.9e-07 30.1 9.8 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 AMD22695.1 - 3.1e-07 30.3 8.0 3.1e-07 30.3 8.0 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 AMD22695.1 - 5.3e-07 29.5 11.4 7.1e-06 25.9 7.6 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 AMD22695.1 - 5.8e-07 29.7 11.4 8.8e-07 29.2 7.3 2.4 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 AMD22695.1 - 1.2e-06 28.7 6.9 1.3e-06 28.6 3.5 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 AMD22695.1 - 2.2e-06 27.4 8.8 1.1e-05 25.2 5.8 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-Di19 PF05605.12 AMD22695.1 - 0.00017 21.8 2.4 0.005 17.1 0.1 2.8 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding RNF220 PF15926.5 AMD22695.1 - 0.00059 19.5 6.2 0.0018 17.9 6.2 1.9 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 zf-ANAPC11 PF12861.7 AMD22695.1 - 0.0042 17.1 2.7 0.017 15.2 1.4 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 AMD22695.1 - 0.0049 17.0 7.0 0.0049 17.0 7.0 2.3 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_4 PF14570.6 AMD22695.1 - 0.0053 16.5 6.7 0.021 14.6 1.7 2.6 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 AMD22695.1 - 0.009 15.8 4.6 1.3 8.9 0.1 4.1 3 0 0 3 3 3 1 Rad50 zinc hook motif zf-Nse PF11789.8 AMD22695.1 - 0.014 15.2 6.9 0.077 12.8 2.8 2.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 AMD22695.1 - 0.038 14.2 0.0 0.34 11.1 0.0 2.3 2 0 0 2 2 2 0 U-box domain Zn-ribbon_8 PF09723.10 AMD22695.1 - 0.17 12.1 3.6 13 6.0 1.5 2.6 2 0 0 2 2 2 0 Zinc ribbon domain Zn-C2H2_12 PF18112.1 AMD22695.1 - 0.31 11.5 4.4 0.35 11.4 0.5 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Forkhead PF00250.18 AMD22696.1 - 2.8e-33 114.0 0.0 5.7e-33 113.0 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain Pox_Ag35 PF03286.14 AMD22696.1 - 0.026 14.3 0.4 0.026 14.3 0.4 2.4 3 0 0 3 3 3 0 Pox virus Ag35 surface protein G10 PF01125.17 AMD22697.1 - 9.8e-56 187.6 5.9 1.2e-55 187.3 5.9 1.1 1 0 0 1 1 1 1 G10 protein THB PF18362.1 AMD22697.1 - 0.027 14.0 0.2 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Tri-helix bundle domain Ytp1 PF10355.9 AMD22698.1 - 4.7e-107 357.3 17.1 6.5e-107 356.9 15.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 AMD22698.1 - 3e-25 88.0 6.9 3e-25 88.0 6.9 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Ctr PF04145.15 AMD22698.1 - 0.012 16.2 0.2 0.45 11.1 0.0 2.6 2 0 0 2 2 2 0 Ctr copper transporter family Glucan_synthase PF02364.15 AMD22699.1 - 0 1073.2 2.0 0 1073.2 2.0 2.0 2 0 0 2 2 2 2 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AMD22699.1 - 2.5e-25 89.3 1.8 6.2e-24 84.8 1.8 2.7 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 TPR_2 PF07719.17 AMD22700.1 - 1.9e-09 36.9 0.1 2.8e-05 23.9 0.4 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 AMD22700.1 - 3.7e-09 36.0 0.5 0.00013 21.6 0.8 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 AMD22700.1 - 1.3e-07 31.2 0.1 3e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 AMD22700.1 - 0.0003 21.0 0.0 0.0058 16.9 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AMD22700.1 - 0.00035 20.7 0.1 0.00057 20.1 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 AMD22700.1 - 0.00092 19.4 1.0 0.0024 18.1 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 AMD22700.1 - 0.0014 19.1 0.0 0.0023 18.4 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 AMD22700.1 - 0.0049 16.8 0.1 0.037 14.1 0.0 2.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 AMD22700.1 - 0.012 16.3 0.0 0.02 15.5 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 AMD22700.1 - 0.012 16.4 0.0 0.065 14.1 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 AMD22700.1 - 0.042 14.1 0.8 0.17 12.2 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR_long PF17177.4 AMD22700.1 - 0.042 13.2 0.1 0.047 13.1 0.1 1.2 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP MIT PF04212.18 AMD22700.1 - 0.056 13.5 3.8 0.28 11.3 0.4 2.5 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain UPF0029 PF01205.19 AMD22701.1 - 1.5e-31 108.9 0.1 2.5e-31 108.1 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 AMD22701.1 - 7.4e-08 32.7 2.5 1.5e-07 31.7 1.1 2.2 2 1 0 2 2 2 1 RWD domain MPP6 PF10175.9 AMD22702.1 - 5.5e-20 72.2 6.9 9.7e-20 71.4 6.9 1.4 1 1 0 1 1 1 1 M-phase phosphoprotein 6 Utp14 PF04615.13 AMD22702.1 - 0.002 16.8 8.9 0.0031 16.2 8.9 1.3 1 1 0 1 1 1 1 Utp14 protein RanGAP1_C PF07834.11 AMD22703.1 - 0.054 13.1 0.1 0.26 10.9 0.2 2.1 2 0 0 2 2 2 0 RanGAP1 C-terminal domain TFIIA PF03153.13 AMD22703.1 - 0.14 12.1 28.5 0.2 11.7 28.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SUIM_assoc PF16619.5 AMD22703.1 - 1.7 8.8 17.5 6.6 6.9 17.5 2.1 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Isochorismatase PF00857.20 AMD22704.1 - 4.3e-21 75.9 0.4 1.2e-20 74.5 0.4 1.7 1 1 0 1 1 1 1 Isochorismatase family Gly_transf_sug PF04488.15 AMD22705.1 - 1.4e-13 51.2 0.1 3.7e-13 49.9 0.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TMEM52 PF14979.6 AMD22706.1 - 0.02 14.8 0.3 0.026 14.4 0.3 1.3 1 0 0 1 1 1 0 Transmembrane 52 Androgen_recep PF02166.16 AMD22706.1 - 0.32 9.8 7.2 0.36 9.6 7.2 1.1 1 0 0 1 1 1 0 Androgen receptor Ras PF00071.22 AMD22707.1 - 4.8e-51 172.6 0.0 5.9e-51 172.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22707.1 - 9.2e-18 64.6 0.0 1.4e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD22707.1 - 3.5e-09 36.4 0.1 4.2e-09 36.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AMD22707.1 - 9.6e-06 25.3 0.1 2.2e-05 24.1 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AMD22707.1 - 0.0015 18.5 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AMD22707.1 - 0.005 16.9 0.0 0.0098 16.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 AMD22707.1 - 0.14 11.3 0.1 2.9 7.0 0.0 2.2 2 1 0 2 2 2 0 G-protein alpha subunit MRP-L28 PF09812.9 AMD22708.1 - 8.5e-31 107.3 3.2 1.1e-30 106.9 3.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 FYRC PF05965.14 AMD22708.1 - 0.063 13.4 1.5 0.49 10.6 0.2 2.2 1 1 0 2 2 2 0 F/Y rich C-terminus TPT PF03151.16 AMD22709.1 - 1.5e-20 73.7 15.3 1.8e-20 73.5 15.3 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 AMD22709.1 - 1.9e-08 33.9 18.7 6.6e-08 32.1 18.7 1.7 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 AMD22709.1 - 1.4e-05 25.3 31.7 0.0022 18.2 16.8 2.9 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 AMD22709.1 - 3.2e-05 23.3 5.2 0.031 13.4 0.6 2.3 2 0 0 2 2 2 2 Nucleotide-sugar transporter PUNUT PF16913.5 AMD22709.1 - 8.3e-05 22.0 16.7 0.00022 20.6 16.7 1.6 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport TMEM234 PF10639.9 AMD22709.1 - 0.072 13.1 8.8 1.5 8.9 2.3 2.7 3 0 0 3 3 3 0 Putative transmembrane family 234 COX14 PF14880.6 AMD22709.1 - 6.6 6.7 8.7 1.7 8.5 0.8 2.8 2 0 0 2 2 2 0 Cytochrome oxidase c assembly zf-C2H2_4 PF13894.6 AMD22710.1 - 0.00042 20.9 14.6 0.038 14.8 1.0 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HE PF16278.5 AMD22710.1 - 0.00071 20.0 1.8 0.67 10.5 0.0 3.6 3 0 0 3 3 3 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 AMD22710.1 - 0.0012 19.2 2.0 0.0012 19.2 2.0 3.9 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD22710.1 - 0.0067 16.8 14.4 0.0087 16.5 1.4 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_3rep PF18868.1 AMD22710.1 - 0.014 16.0 0.1 0.098 13.3 0.0 2.3 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats PyrI_C PF02748.15 AMD22710.1 - 0.048 13.6 0.7 0.48 10.4 0.2 2.5 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 AMD22710.1 - 0.41 11.0 6.3 16 5.9 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF3020 PF11223.8 AMD22711.1 - 3.7e-19 69.0 9.9 3.7e-19 69.0 9.9 8.2 8 1 0 8 8 8 1 Protein of unknown function (DUF3020) UIM PF02809.20 AMD22711.1 - 5 7.3 7.8 0.52 10.3 1.4 2.9 2 0 0 2 2 2 0 Ubiquitin interaction motif Sybindin PF04099.12 AMD22712.1 - 2.5e-38 131.2 1.1 1.5e-23 83.3 0.1 2.1 2 0 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.13 AMD22712.1 - 8.7e-09 35.6 0.6 1.6e-08 34.8 0.3 1.5 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region SAC3_GANP PF03399.16 AMD22712.1 - 0.14 11.5 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 SAC3/GANP family RMI1_N PF08585.12 AMD22713.1 - 2e-20 73.5 0.0 2.3e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 RecQ mediated genome instability protein MTHFR PF02219.17 AMD22714.1 - 1.3e-104 349.6 0.0 1.6e-104 349.3 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ERCC4 PF02732.15 AMD22715.1 - 2.2e-20 73.5 0.0 1.5e-19 70.8 0.0 2.3 2 0 0 2 2 2 1 ERCC4 domain RFC1 PF08519.12 AMD22716.1 - 5.6e-57 192.3 0.2 1.3e-56 191.1 0.2 1.7 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 AMD22716.1 - 1.2e-11 45.2 0.5 9.5e-11 42.3 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 AMD22716.1 - 4.8e-11 42.9 0.0 1.4e-10 41.4 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 AMD22716.1 - 7.9e-07 29.2 0.1 2.8e-06 27.4 0.1 1.9 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 AMD22716.1 - 0.0001 22.1 0.0 0.00021 21.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 AMD22716.1 - 0.00044 20.4 0.0 0.0012 19.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD22716.1 - 0.0015 19.0 0.4 0.0074 16.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AMD22716.1 - 0.0017 18.8 0.0 0.012 16.1 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_assoc_2 PF16193.5 AMD22716.1 - 0.0027 18.0 0.0 0.01 16.2 0.0 2.0 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 AMD22716.1 - 0.003 17.6 0.1 0.026 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AMD22716.1 - 0.0069 16.8 1.1 0.059 13.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AMD22716.1 - 0.0082 16.4 0.0 0.12 12.7 0.0 2.8 3 1 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 AMD22716.1 - 0.013 15.9 0.1 0.049 14.0 0.0 2.1 2 0 0 2 2 1 0 RNA helicase NTPase_1 PF03266.15 AMD22716.1 - 0.028 14.3 0.0 0.11 12.4 0.0 2.1 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.6 AMD22716.1 - 0.042 14.1 0.2 0.46 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 AMD22716.1 - 0.13 12.2 0.0 0.49 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Ribosomal_L5 PF00281.19 AMD22716.1 - 0.14 12.5 0.5 1.3 9.4 0.0 3.0 2 0 0 2 2 2 0 Ribosomal protein L5 GRAB PF10375.9 AMD22717.1 - 7.4e-07 28.8 2.7 1.7e-06 27.7 2.7 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain ATG16 PF08614.11 AMD22717.1 - 8e-07 29.5 57.9 0.073 13.3 2.7 4.7 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 AMD22717.1 - 5e-05 23.6 57.0 0.0011 19.2 20.7 3.3 1 1 2 3 3 3 2 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 AMD22717.1 - 0.0018 17.8 51.5 0.36 10.2 26.1 3.0 1 1 1 2 2 2 2 Golgin subfamily A member 5 Atg14 PF10186.9 AMD22717.1 - 0.0023 17.1 22.3 0.0023 17.1 22.3 2.9 1 1 2 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 AMD22717.1 - 0.07 12.0 53.0 0.32 9.8 25.0 2.7 1 1 2 3 3 3 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.11 AMD22717.1 - 0.07 13.7 32.5 0.046 14.3 6.5 4.0 2 1 2 4 4 4 0 Syntaxin 6, N-terminal DUF2935 PF11155.8 AMD22717.1 - 0.098 13.0 10.2 6.7 7.1 5.0 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF2935) Fez1 PF06818.15 AMD22717.1 - 0.15 12.5 49.9 0.34 11.3 27.4 3.6 1 1 2 3 3 3 0 Fez1 Filament PF00038.21 AMD22717.1 - 0.18 11.4 47.1 0.15 11.7 42.1 3.3 1 1 1 2 2 2 0 Intermediate filament protein DUF724 PF05266.14 AMD22717.1 - 0.38 10.5 47.2 0.18 11.6 13.2 4.2 1 1 4 5 5 5 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 AMD22717.1 - 0.42 10.8 53.1 0.33 11.2 6.4 5.1 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF812 PF05667.11 AMD22717.1 - 0.72 8.7 49.7 4.7 6.0 48.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF812) SAP PF02037.27 AMD22717.1 - 1 9.2 8.1 0.22 11.3 0.5 3.6 4 0 0 4 4 4 0 SAP domain APG6_N PF17675.1 AMD22717.1 - 1.1 9.8 59.7 0.49 10.9 21.6 3.7 1 1 2 3 3 3 0 Apg6 coiled-coil region TRAF_BIRC3_bd PF16673.5 AMD22717.1 - 1.9 8.3 19.3 0.09 12.6 0.5 4.2 3 2 1 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain Fumble PF03630.14 AMD22717.1 - 2.2 7.4 8.4 4.7 6.3 8.4 1.5 1 0 0 1 1 1 0 Fumble GAS PF13851.6 AMD22717.1 - 3.1 7.1 56.7 1 8.7 22.1 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 AMD22717.1 - 3.2 7.8 50.1 0.58 10.2 11.8 4.4 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding UPF0242 PF06785.11 AMD22717.1 - 3.3 7.8 55.5 1.3 9.1 16.4 3.6 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Band_7_1 PF13421.6 AMD22717.1 - 4.2 7.0 8.1 0.28 10.9 1.2 2.4 2 1 1 3 3 3 0 SPFH domain-Band 7 family TPR_MLP1_2 PF07926.12 AMD22717.1 - 5.2 7.1 60.6 3.1 7.9 21.1 4.7 2 2 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4763 PF15960.5 AMD22717.1 - 6.4 6.0 44.3 29 3.9 3.1 3.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) YqeY PF09424.10 AMD22718.1 - 2.1e-19 70.0 3.6 2.5e-19 69.8 3.6 1.1 1 0 0 1 1 1 1 Yqey-like protein DDE_1 PF03184.19 AMD22718.1 - 0.033 13.8 0.5 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease YEATS PF03366.16 AMD22719.1 - 1.4e-19 69.8 0.0 2.5e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 YEATS family BET PF17035.5 AMD22719.1 - 7.6e-07 29.2 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation EF1_GNE PF00736.19 AMD22719.1 - 0.11 12.7 0.0 0.72 10.1 0.1 2.1 2 0 0 2 2 2 0 EF-1 guanine nucleotide exchange domain YEATS PF03366.16 AMD22720.1 - 6.8e-17 61.2 0.0 1.2e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 YEATS family DUF2194 PF09960.9 AMD22720.1 - 0.082 11.2 0.0 0.098 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) WD40 PF00400.32 AMD22721.1 - 2.5e-28 97.8 21.8 6e-06 26.9 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22721.1 - 4.6e-14 52.5 0.2 0.043 14.1 0.0 5.3 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AMD22721.1 - 0.002 17.5 0.5 0.099 11.9 0.5 2.5 1 1 1 2 2 2 2 WD40-like domain TRF PF08558.10 AMD22722.1 - 9.8e-65 218.5 0.1 1.6e-64 217.8 0.1 1.3 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 AMD22722.1 - 2.1e-07 31.0 0.7 7e-07 29.3 0.7 1.9 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD22722.1 - 0.0069 16.6 0.1 0.02 15.2 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Linker_histone PF00538.19 AMD22723.1 - 2.9e-24 85.2 0.0 2.9e-24 85.2 0.0 3.1 3 1 0 3 3 3 1 linker histone H1 and H5 family HC2 PF07382.11 AMD22723.1 - 0.0042 17.2 38.7 0.0042 17.2 38.7 2.0 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 Dynamin_N PF00350.23 AMD22724.1 - 2.3e-42 144.9 0.2 2.3e-42 144.9 0.2 2.5 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 AMD22724.1 - 1.9e-06 27.9 0.1 4.1e-05 23.6 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 AMD22724.1 - 3.9e-05 23.0 8.1 0.0001 21.7 4.1 3.0 2 1 0 2 2 2 1 Dynamin central region AAA_16 PF13191.6 AMD22724.1 - 0.0013 19.1 1.2 0.038 14.4 0.0 3.5 3 1 0 3 3 3 1 AAA ATPase domain AKAP7_RIRII_bdg PF10470.9 AMD22724.1 - 0.054 13.6 0.5 0.21 11.7 0.1 2.2 2 0 0 2 2 2 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein Roc PF08477.13 AMD22724.1 - 0.098 12.9 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RNA_pol_N PF01194.17 AMD22725.1 - 9.2e-30 102.7 0.5 1e-29 102.6 0.5 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 AMD22725.1 - 0.058 13.7 0.1 0.077 13.3 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) WD40 PF00400.32 AMD22726.1 - 0.00018 22.3 10.2 0.033 15.1 0.5 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat NAPRTase PF04095.16 AMD22728.1 - 1.6e-69 234.2 0.0 2e-69 233.9 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 AMD22728.1 - 9.6e-34 116.5 0.2 1.9e-33 115.5 0.2 1.5 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain IBN_N PF03810.19 AMD22729.1 - 8.5e-18 64.1 1.1 3.4e-15 55.7 0.0 3.5 4 0 0 4 4 4 2 Importin-beta N-terminal domain Xpo1 PF08389.12 AMD22729.1 - 0.25 11.4 7.9 0.25 11.4 0.1 4.5 4 2 1 5 5 5 0 Exportin 1-like protein Y_phosphatase PF00102.27 AMD22730.1 - 9.6e-59 198.8 0.6 2.7e-58 197.3 0.6 1.8 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 AMD22730.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 AMD22730.1 - 0.064 13.1 0.1 0.57 10.0 0.0 2.6 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Imm41 PF15592.6 AMD22730.1 - 0.073 13.4 0.2 0.16 12.3 0.2 1.6 1 0 0 1 1 1 0 Immunity protein 41 p25-alpha PF05517.12 AMD22730.1 - 0.12 12.6 1.9 0.51 10.5 0.1 2.4 2 0 0 2 2 2 0 p25-alpha Spc29 PF17082.5 AMD22731.1 - 9.5e-53 179.5 5.3 1.2e-52 179.3 5.3 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 CCDC106 PF15794.5 AMD22731.1 - 0.12 12.0 1.9 0.23 11.1 1.6 1.6 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 106 Ribonuclease_T2 PF00445.18 AMD22732.1 - 4.3e-36 124.9 0.0 6.3e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family putAbiC PF16872.5 AMD22732.1 - 0.17 12.6 0.2 0.28 11.9 0.2 1.3 1 0 0 1 1 1 0 Putative phage abortive infection protein Ribosomal_S27e PF01667.17 AMD22733.1 - 1.4e-29 101.6 3.3 1.8e-29 101.2 3.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.21 AMD22733.1 - 0.0035 17.5 1.1 0.0042 17.3 1.1 1.2 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain TF_Zn_Ribbon PF08271.12 AMD22733.1 - 0.024 14.2 4.2 0.035 13.6 4.2 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding zf-ACC PF17848.1 AMD22733.1 - 3.1 7.9 6.4 19 5.4 0.2 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Rsm22 PF09243.10 AMD22734.1 - 7.4e-29 100.9 0.4 5.6e-11 42.2 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 AMD22734.1 - 0.00048 20.0 0.0 0.0025 17.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain NUP50 PF08911.11 AMD22734.1 - 0.0032 18.1 3.3 0.12 13.0 2.6 2.8 2 0 0 2 2 2 1 NUP50 (Nucleoporin 50 kDa) SRPRB PF09439.10 AMD22735.1 - 1.3e-54 184.4 0.7 1.6e-54 184.1 0.7 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 AMD22735.1 - 6.6e-11 42.0 0.0 9e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD22735.1 - 9.8e-11 41.7 0.1 1.8e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD22735.1 - 2.5e-06 27.1 0.1 3.5e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 AMD22735.1 - 0.00011 21.8 0.1 0.016 14.8 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 AMD22735.1 - 0.00014 21.3 0.2 0.00019 20.9 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 AMD22735.1 - 0.00016 21.9 0.0 0.00025 21.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AMD22735.1 - 0.0032 17.1 0.0 0.0042 16.7 0.0 1.2 1 0 0 1 1 1 1 Ras family ATPase_2 PF01637.18 AMD22735.1 - 0.0042 17.0 0.7 0.1 12.5 0.0 2.2 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 AMD22735.1 - 0.0091 15.9 1.3 0.035 14.0 0.1 2.2 2 1 1 3 3 3 1 RsgA GTPase TPM_phosphatase PF04536.14 AMD22735.1 - 0.027 14.7 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 TPM domain AAA_21 PF13304.6 AMD22735.1 - 0.03 14.1 0.7 0.047 13.5 0.7 1.7 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PduV-EutP PF10662.9 AMD22735.1 - 0.051 13.3 0.1 1.3 8.8 0.1 2.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 AMD22735.1 - 0.055 14.0 0.5 0.14 12.7 0.5 2.0 1 1 0 1 1 1 0 ABC transporter Dynamin_N PF00350.23 AMD22735.1 - 0.072 13.2 3.8 2.5 8.2 0.7 2.5 1 1 2 3 3 3 0 Dynamin family DPM2 PF07297.12 AMD22736.1 - 1.1e-10 41.6 8.0 1.3e-10 41.4 8.0 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 AMD22736.1 - 0.67 9.9 6.4 0.79 9.6 6.4 1.1 1 0 0 1 1 1 0 PIG-P Nup192 PF11894.8 AMD22737.1 - 0 1655.9 62.3 0 1655.7 62.3 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Nsp1_C PF05064.13 AMD22738.1 - 9.2e-41 138.3 7.3 9.2e-41 138.3 7.3 2.0 1 1 1 2 2 2 1 Nsp1-like C-terminal region DNA_primase_lrg PF04104.14 AMD22738.1 - 0.093 12.1 1.9 0.15 11.5 1.2 1.6 1 1 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit APG6_N PF17675.1 AMD22738.1 - 1.1 9.8 10.3 2.2 8.8 10.3 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region LRR_6 PF13516.6 AMD22739.1 - 0.0068 16.4 5.2 3.7 7.9 0.0 4.4 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 AMD22739.1 - 0.19 12.2 12.4 0.99 9.9 1.8 4.5 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) RabGAP-TBC PF00566.18 AMD22741.1 - 1.9e-22 80.0 2.3 2.7e-22 79.5 2.3 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain His_Phos_1 PF00300.22 AMD22742.1 - 2.9e-36 125.0 0.0 7.6e-28 97.5 0.1 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Carb_kinase PF01256.17 AMD22743.1 - 4.5e-50 170.4 0.0 1.3e-49 168.8 0.0 1.7 1 1 0 1 1 1 1 Carbohydrate kinase NAD_binding_1 PF00175.21 AMD22744.1 - 3.5e-30 104.9 0.0 5.1e-30 104.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AMD22744.1 - 3e-26 91.6 0.0 5.2e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AMD22744.1 - 1.6e-08 34.8 0.0 3.6e-06 27.2 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain DBR1 PF05011.13 AMD22745.1 - 5.3e-11 43.1 0.1 8.5e-11 42.4 0.1 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 AMD22745.1 - 1e-06 29.4 0.1 1.6e-06 28.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FAD_binding_2 PF00890.24 AMD22746.1 - 3.1e-123 412.0 3.1 3.9e-123 411.6 3.1 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 AMD22746.1 - 1e-44 151.6 0.7 1.5e-44 151.0 0.7 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 AMD22746.1 - 3.2e-06 26.5 1.7 0.0012 18.0 1.3 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 AMD22746.1 - 3.1e-05 23.3 0.2 0.00011 21.5 0.0 2.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AMD22746.1 - 0.00029 20.1 0.2 0.011 15.0 0.1 2.6 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 AMD22746.1 - 0.0015 17.9 1.3 0.0071 15.6 0.1 2.4 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 AMD22746.1 - 0.022 13.5 0.5 0.098 11.3 0.2 2.2 3 0 0 3 3 3 0 HI0933-like protein DAO PF01266.24 AMD22746.1 - 0.023 14.3 3.8 0.087 12.4 3.8 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase Aa_trans PF01490.18 AMD22747.1 - 9.2e-96 321.0 30.6 1.1e-95 320.8 30.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AAA PF00004.29 AMD22748.1 - 1.9e-40 138.3 0.0 5.9e-40 136.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD22748.1 - 4.2e-07 29.7 0.0 1.1e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 AMD22748.1 - 5.3e-05 23.2 0.0 0.0002 21.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AMD22748.1 - 6.3e-05 23.3 0.0 0.0027 18.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 AMD22748.1 - 0.00017 22.0 0.1 0.004 17.5 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 AMD22748.1 - 0.00037 20.6 0.0 0.00077 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 AMD22748.1 - 0.0008 18.6 0.0 0.0015 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 AMD22748.1 - 0.0044 16.8 0.0 0.0078 16.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AMD22748.1 - 0.011 15.9 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AMD22748.1 - 0.018 15.2 0.0 0.054 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AMD22748.1 - 0.029 14.1 0.1 0.086 12.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AMD22748.1 - 0.032 14.8 0.0 0.075 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 AMD22748.1 - 0.035 14.5 0.0 0.083 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 AMD22748.1 - 0.038 13.5 0.0 0.089 12.3 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region CaATP_NAI PF12515.8 AMD22748.1 - 0.04 13.5 0.0 0.51 10.0 0.0 2.4 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain ATPase_2 PF01637.18 AMD22748.1 - 0.041 13.8 0.6 5.2 6.9 0.0 2.6 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_3 PF07726.11 AMD22748.1 - 0.046 13.6 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 AMD22748.1 - 0.051 13.0 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 AMD22748.1 - 0.055 12.7 0.0 0.095 11.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 AMD22748.1 - 0.11 12.3 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_pol_Rbc25 PF08292.12 AMD22749.1 - 4.5e-51 172.4 0.3 5.9e-51 172.1 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 AMD22749.1 - 2.2e-19 69.6 0.0 3.4e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AMD22749.1 - 0.033 14.5 0.0 0.058 13.7 0.0 1.4 1 1 0 1 1 1 0 S1 RNA binding domain LTV PF04180.14 AMD22750.1 - 3.7e-106 356.1 24.9 4.4e-106 355.8 24.9 1.0 1 0 0 1 1 1 1 Low temperature viability protein DUF3294 PF07957.11 AMD22751.1 - 3.3e-88 295.0 4.6 3.7e-88 294.8 4.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) FlaC_arch PF05377.11 AMD22751.1 - 0.075 13.4 2.4 11 6.5 0.0 3.3 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 AMD22751.1 - 0.079 13.0 1.1 8.2 6.4 0.1 2.7 3 0 0 3 3 3 0 Laminin Domain II BLOC1_2 PF10046.9 AMD22751.1 - 3.8 7.9 9.7 1.3 9.4 0.3 3.2 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PUF PF00806.19 AMD22752.1 - 9.5e-27 91.2 12.4 0.00016 21.1 0.0 8.9 9 0 0 9 9 9 6 Pumilio-family RNA binding repeat LIDHydrolase PF10230.9 AMD22752.1 - 0.036 13.6 2.4 4.1 6.9 0.3 3.7 2 2 2 4 4 4 0 Lipid-droplet associated hydrolase FANCI_S1-cap PF14674.6 AMD22752.1 - 0.3 11.2 1.6 0.43 10.7 0.1 2.2 2 0 0 2 2 2 0 FANCI solenoid 1 cap Cpn60_TCP1 PF00118.24 AMD22753.1 - 3e-147 491.2 8.7 3.5e-147 491.0 8.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nitro_FeMo-Co PF02579.17 AMD22753.1 - 0.017 15.5 0.0 0.48 10.8 0.0 2.7 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor PucR PF07905.11 AMD22753.1 - 0.047 14.0 0.0 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family Vps53_N PF04100.12 AMD22754.1 - 4.8e-82 275.9 13.8 7e-82 275.4 13.8 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal VPS53_C PF16854.5 AMD22754.1 - 6.8e-58 195.9 4.2 1.5e-57 194.7 4.2 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 53 C-terminus DUF3724 PF12521.8 AMD22754.1 - 0.12 12.3 0.1 0.35 10.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) HORMA PF02301.18 AMD22755.1 - 9.1e-24 84.2 0.3 1.3e-23 83.7 0.3 1.2 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.9 AMD22755.1 - 0.00061 19.5 0.0 0.0022 17.7 0.0 1.8 2 0 0 2 2 2 1 Autophagy-related protein 13 DUF3440 PF11922.8 AMD22755.1 - 0.0084 15.8 0.1 0.012 15.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3440) RsbRD_N PF14361.6 AMD22755.1 - 0.082 13.6 0.1 0.17 12.6 0.1 1.5 1 0 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain PPTA PF01239.22 AMD22756.1 - 3.8e-38 128.1 14.4 1.5e-09 37.3 1.8 6.0 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat Cyclin_N PF00134.23 AMD22757.1 - 3.1e-14 52.8 6.4 5.2e-13 48.8 2.3 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 AMD22757.1 - 0.011 15.8 0.1 0.2 11.7 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat DEAD PF00270.29 AMD22758.1 - 4.8e-46 156.7 0.0 1.2e-45 155.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22758.1 - 1.4e-22 80.1 0.0 6.2e-22 78.0 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AMD22758.1 - 1.2e-21 76.7 0.0 2.6e-21 75.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AMD22758.1 - 4.6e-06 26.7 2.0 4.6e-06 26.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit LRR_9 PF14580.6 AMD22758.1 - 0.089 12.3 0.8 1.4 8.4 0.0 2.8 3 0 0 3 3 3 0 Leucine-rich repeat FHA PF00498.26 AMD22759.1 - 5.2e-12 45.9 0.0 1.1e-11 44.9 0.0 1.7 1 1 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 AMD22759.1 - 0.019 15.3 0.0 0.06 13.7 0.0 1.8 2 0 0 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain Pox_F11 PF04943.12 AMD22759.1 - 0.09 11.8 0.2 0.35 9.9 0.2 1.8 1 1 1 2 2 2 0 Poxvirus F11 protein HSP70 PF00012.20 AMD22760.1 - 1.3e-263 875.7 12.2 1.5e-263 875.5 12.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AMD22760.1 - 2.6e-19 69.2 1.5 1.1e-17 63.9 0.3 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 AMD22760.1 - 0.00098 19.5 3.4 0.26 11.7 0.1 3.6 3 2 0 3 3 3 2 Cell division protein FtsA Hydantoinase_A PF01968.18 AMD22760.1 - 0.0012 18.2 1.8 0.08 12.2 0.1 2.8 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase FGGY_C PF02782.16 AMD22760.1 - 0.02 14.6 0.0 0.14 11.9 0.0 2.4 3 0 0 3 3 3 0 FGGY family of carbohydrate kinases, C-terminal domain Rep_1 PF01446.17 AMD22760.1 - 0.47 9.9 1.8 0.97 8.8 1.8 1.4 1 0 0 1 1 1 0 Replication protein Nramp PF01566.18 AMD22761.1 - 6.6e-90 301.7 17.2 1.2e-89 300.8 17.2 1.3 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein Med30 PF11315.8 AMD22762.1 - 0.056 13.6 4.4 0.06 13.6 0.6 2.5 2 0 0 2 2 2 0 Mediator complex subunit 30 RNase_PH PF01138.21 AMD22763.1 - 1.3e-28 100.1 0.0 1.8e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AMD22763.1 - 8.5e-05 22.5 0.2 0.00023 21.1 0.2 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Mannosyl_trans PF05007.13 AMD22764.1 - 5.8e-79 265.6 26.0 5.8e-79 265.6 26.0 1.7 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 AMD22764.1 - 6.3e-10 38.7 22.9 1.6e-09 37.3 21.9 2.1 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 AMD22764.1 - 3.2e-06 27.1 14.1 3.2e-06 27.1 14.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 87 DUF5572 PF17733.1 AMD22765.1 - 8.9e-09 35.1 0.3 1.9e-08 34.0 0.3 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5572) NOC3p PF07540.11 AMD22766.1 - 7.8e-27 93.6 1.0 7.8e-27 93.6 1.0 3.4 4 1 0 4 4 4 1 Nucleolar complex-associated protein CBF PF03914.17 AMD22766.1 - 1.5e-25 90.2 0.1 1.5e-25 90.2 0.1 2.5 3 0 0 3 3 3 1 CBF/Mak21 family Ssl1 PF04056.14 AMD22766.1 - 0.018 14.8 0.9 0.22 11.3 0.0 2.6 3 0 0 3 3 3 0 Ssl1-like Ovate PF04844.13 AMD22766.1 - 0.041 13.9 3.2 3.2 7.8 0.1 3.1 3 0 0 3 3 3 0 Transcriptional repressor, ovate DUF5308 PF17233.2 AMD22766.1 - 0.064 13.5 2.0 2.8 8.2 0.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Mpp10 PF04006.12 AMD22767.1 - 6e-139 464.3 50.7 7.4e-139 464.0 50.7 1.0 1 0 0 1 1 1 1 Mpp10 protein Aa_trans PF01490.18 AMD22768.1 - 5.1e-77 259.3 18.0 6e-77 259.1 18.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Prominin PF05478.11 AMD22768.1 - 0.37 8.7 1.5 0.44 8.5 1.5 1.1 1 0 0 1 1 1 0 Prominin Fasciclin PF02469.22 AMD22769.1 - 5e-24 85.0 0.4 3.2e-06 27.4 0.0 6.0 5 2 0 5 5 5 5 Fasciclin domain Dynamin_M PF01031.20 AMD22770.1 - 7.6e-109 363.3 0.0 1.4e-108 362.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 AMD22770.1 - 1.8e-55 187.5 0.2 6.4e-55 185.8 0.0 2.0 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 AMD22770.1 - 2.1e-29 101.5 1.6 8.7e-29 99.5 1.6 2.2 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AMD22770.1 - 9.1e-05 22.5 0.7 0.0029 17.7 0.2 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 AMD22770.1 - 1.5 8.4 8.6 0.53 9.9 0.0 3.2 3 0 0 3 3 3 0 AAA ATPase domain HAT_KAT11 PF08214.11 AMD22771.1 - 8.1e-93 311.5 0.8 9.9e-93 311.2 0.8 1.0 1 0 0 1 1 1 1 Histone acetylation protein Proteasome PF00227.26 AMD22772.1 - 1.1e-48 165.3 0.6 1.2e-48 165.1 0.6 1.0 1 0 0 1 1 1 1 Proteasome subunit Pox_A51 PF04948.13 AMD22772.1 - 0.12 11.2 0.1 0.18 10.6 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A51 protein Sfi1 PF08457.10 AMD22773.1 - 1e-32 113.4 59.1 3.8e-28 98.4 43.8 3.4 1 1 2 3 3 3 3 Sfi1 spindle body protein Sfi1_C PF10638.9 AMD22773.1 - 2.7e-25 89.2 5.1 6.8e-25 87.8 4.4 2.2 2 0 0 2 2 2 1 Spindle body associated protein C-terminus Ribophorin_I PF04597.14 AMD22774.1 - 2e-116 389.8 1.7 2.3e-116 389.6 1.7 1.0 1 0 0 1 1 1 1 Ribophorin I ORC_WH_C PF18137.1 AMD22775.1 - 1.1e-21 77.3 0.0 2.4e-21 76.3 0.0 1.6 1 0 0 1 1 1 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 AMD22775.1 - 4.1e-08 32.7 0.9 8.1e-07 28.4 0.5 2.4 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus COX16 PF14138.6 AMD22776.1 - 1.7e-30 105.3 0.2 3e-30 104.5 0.2 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 RSN1_7TM PF02714.15 AMD22777.1 - 1.9e-78 263.6 30.5 4.6e-78 262.3 24.1 3.4 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AMD22777.1 - 3.6e-29 101.5 3.6 3.6e-29 101.5 3.6 2.8 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 AMD22777.1 - 5.3e-07 29.7 0.0 1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 AMD22777.1 - 0.00094 19.5 0.9 0.0092 16.2 0.9 2.2 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter MMM1 PF10296.9 AMD22778.1 - 7.7e-140 465.6 0.4 1e-139 465.2 0.4 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 FerA PF08165.11 AMD22778.1 - 0.027 14.4 0.1 0.082 12.9 0.1 1.8 1 0 0 1 1 1 0 FerA (NUC095) domain PH_12 PF16457.5 AMD22779.1 - 2.7e-08 34.4 1.0 5.5e-07 30.2 0.1 3.3 3 1 0 3 3 3 1 Pleckstrin homology domain DEAD PF00270.29 AMD22780.1 - 1e-45 155.7 0.0 1.9e-45 154.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22780.1 - 5.7e-29 100.7 2.2 1.6e-28 99.3 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AMD22780.1 - 0.035 14.4 0.3 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain SYS1 PF09801.9 AMD22781.1 - 1.3e-50 171.3 14.7 1.5e-50 171.1 14.7 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network LRR_8 PF13855.6 AMD22782.1 - 6e-43 144.4 89.3 2.8e-10 39.8 4.6 10.4 9 2 1 10 10 10 7 Leucine rich repeat PP2C PF00481.21 AMD22782.1 - 3.2e-41 141.7 0.2 4.9e-41 141.1 0.2 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 AMD22782.1 - 5.3e-29 99.8 103.9 1.9e-06 28.1 6.1 13.2 10 3 4 14 14 14 9 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 AMD22782.1 - 2.9e-24 85.7 0.0 5.8e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 AMD22782.1 - 0.0085 15.6 39.9 0.52 9.8 1.8 5.2 1 1 6 7 7 7 5 Leucine-rich repeat Ad_cyc_g-alpha PF08509.11 AMD22782.1 - 0.016 14.9 0.1 0.05 13.3 0.1 1.8 1 0 0 1 1 1 0 Adenylate cyclase G-alpha binding domain Annexin_like PF18411.1 AMD22782.1 - 0.11 12.8 0.0 0.44 10.8 0.0 2.0 1 0 0 1 1 1 0 Annexin-like domain LRR_5 PF13306.6 AMD22782.1 - 1.2 9.2 15.1 3.4 7.6 3.5 4.0 3 1 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) COX17 PF05051.13 AMD22783.1 - 6e-22 77.7 5.9 7.8e-22 77.4 5.9 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 AMD22783.1 - 0.00067 19.7 3.9 0.00095 19.2 3.9 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 AMD22783.1 - 0.049 13.7 5.1 0.2 11.7 0.0 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like PNP_UDP_1 PF01048.20 AMD22784.1 - 1.3e-31 109.7 0.0 1.5e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily NPCC PF08058.11 AMD22785.1 - 7.3e-27 94.0 0.4 1.4e-26 93.1 0.4 1.5 1 0 0 1 1 1 1 Nuclear pore complex component NIF PF03031.18 AMD22786.1 - 1e-52 178.0 0.1 1.7e-52 177.4 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DNA_ligase_IV PF11411.8 AMD22786.1 - 0.0032 17.5 0.3 0.011 15.8 0.3 2.0 1 0 0 1 1 1 1 DNA ligase IV Sof1 PF04158.14 AMD22787.1 - 3.9e-28 97.5 14.4 9.3e-28 96.3 14.4 1.7 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 AMD22787.1 - 9.7e-24 83.2 11.6 6.7e-07 29.9 0.0 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22787.1 - 4.3e-06 26.9 0.1 0.28 11.5 0.0 4.0 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AMD22787.1 - 5.2e-05 22.4 0.9 0.024 13.6 0.2 3.4 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AMD22787.1 - 0.00012 22.0 2.2 0.064 13.1 0.3 3.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 AMD22787.1 - 0.0043 16.4 0.0 0.087 12.1 0.0 2.5 3 0 0 3 3 3 1 WD40-like domain BBS2_Mid PF14783.6 AMD22787.1 - 0.006 16.6 0.4 0.19 11.8 0.1 2.9 2 2 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Phage_spike_2 PF18781.1 AMD22787.1 - 0.15 12.1 0.2 0.41 10.7 0.2 1.7 1 0 0 1 1 1 0 Phage spike trimer Pro-NT_NN PF07421.11 AMD22787.1 - 0.29 11.4 2.4 0.61 10.3 2.4 1.5 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor Abhydro_lipase PF04083.16 AMD22788.1 - 4.5e-15 55.0 0.0 8.7e-15 54.1 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 AMD22788.1 - 2.7e-07 30.5 0.7 2.5e-06 27.3 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Lipase_2 PF01674.18 AMD22788.1 - 0.00096 18.7 0.0 0.0024 17.5 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 2) Abhydrolase_6 PF12697.7 AMD22788.1 - 0.019 15.6 0.0 0.029 15.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AMD22788.1 - 0.023 14.0 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF900 PF05990.12 AMD22788.1 - 0.041 13.4 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 AMD22788.1 - 0.065 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase POC3_POC4 PF10448.9 AMD22789.1 - 5.2e-30 104.4 0.1 6.9e-30 104.0 0.1 1.2 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 ACT_5 PF13710.6 AMD22789.1 - 0.17 11.8 0.2 3.3 7.6 0.0 2.6 3 0 0 3 3 3 0 ACT domain SBDS PF01172.18 AMD22790.1 - 4e-33 113.3 0.4 6.3e-33 112.7 0.4 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 AMD22790.1 - 4.4e-31 107.3 0.7 1.1e-30 106.1 0.3 1.7 2 0 0 2 2 2 1 SBDS protein C-terminal domain PUF PF00806.19 AMD22791.1 - 2.5e-53 174.8 11.2 7e-08 31.8 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF2483 PF10656.9 AMD22791.1 - 0.071 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Hypothetical protein of unknown function (DUF2483) Rab5ip PF07019.12 AMD22792.1 - 4.5e-24 84.9 4.7 5.9e-24 84.5 4.7 1.2 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF383 PF04063.14 AMD22793.1 - 5.6e-65 218.6 1.7 1.5e-64 217.2 0.3 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 AMD22793.1 - 1.1e-21 76.5 0.2 3.8e-21 74.7 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF384) HEAT PF02985.22 AMD22793.1 - 0.00018 21.5 0.1 1.4 9.4 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 AMD22793.1 - 0.00025 21.3 0.0 0.0031 17.8 0.0 2.3 2 0 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 AMD22793.1 - 0.021 14.9 2.7 0.033 14.3 1.7 1.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 TFIIF_alpha PF05793.12 AMD22794.1 - 4.3e-10 38.8 44.2 6.6e-09 34.9 0.7 3.3 2 2 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) tRNA-synt_1b PF00579.25 AMD22795.1 - 1.9e-75 253.9 0.0 2.5e-75 253.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) zf-UBR PF02207.20 AMD22796.1 - 7.5e-12 45.3 10.6 7.5e-12 45.3 10.6 2.3 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ZZ PF00569.17 AMD22796.1 - 1.2 9.0 8.8 5.2 7.0 8.8 2.2 1 0 0 1 1 1 0 Zinc finger, ZZ type zf-B_box PF00643.24 AMD22796.1 - 3.4 7.9 13.1 1.2 9.3 9.3 2.3 2 0 0 2 2 2 0 B-box zinc finger zf-UBR PF02207.20 AMD22797.1 - 2.5e-16 59.6 11.7 2.5e-16 59.6 11.7 2.3 2 0 0 2 2 1 1 Putative zinc finger in N-recognin (UBR box) zf-RING_2 PF13639.6 AMD22797.1 - 0.00018 21.8 0.6 0.00018 21.8 0.6 3.3 3 0 0 3 3 2 1 Ring finger domain ClpS PF02617.17 AMD22797.1 - 0.0018 18.0 0.0 0.0065 16.2 0.0 1.9 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-rbx1 PF12678.7 AMD22797.1 - 0.0045 17.2 0.2 0.015 15.6 0.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AMD22797.1 - 0.0084 16.0 0.6 0.0084 16.0 0.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD22797.1 - 0.026 14.4 0.5 0.026 14.4 0.5 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PPIP5K2_N PF18086.1 AMD22797.1 - 0.05 13.8 0.1 0.21 11.8 0.1 2.1 1 0 0 1 1 1 0 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain TAF4 PF05236.14 AMD22797.1 - 0.12 12.1 1.0 12 5.5 0.0 2.8 3 0 0 3 3 3 0 Transcription initiation factor TFIID component TAF4 family DUF2175 PF09943.9 AMD22797.1 - 0.13 12.6 3.7 0.45 10.8 0.0 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) Kri1 PF05178.12 AMD22797.1 - 0.28 11.8 4.3 0.41 11.2 0.3 3.0 3 0 0 3 3 3 0 KRI1-like family HMW1C_N PF18071.1 AMD22797.1 - 0.48 10.2 4.5 1.5 8.6 0.0 3.8 5 0 0 5 5 5 0 HMW1C N-terminal UCR_UQCRX_QCR9 PF05365.12 AMD22798.1 - 4.2e-26 90.6 1.4 4.6e-26 90.5 1.4 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF2976 PF11190.8 AMD22798.1 - 0.16 11.8 0.1 0.17 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) zf-Tim10_DDP PF02953.15 AMD22799.1 - 1.2e-14 53.7 3.0 1.5e-14 53.3 3.0 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MIEAP PF16026.5 AMD22799.1 - 0.053 13.7 0.1 0.061 13.5 0.1 1.1 1 0 0 1 1 1 0 Mitochondria-eating protein GPAT_N PF14829.6 AMD22799.1 - 0.099 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal Clat_adaptor_s PF01217.20 AMD22800.1 - 2.9e-55 186.1 1.0 3.5e-55 185.8 1.0 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain BPS1 PF05633.11 AMD22800.1 - 0.069 12.2 0.0 0.085 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein BYPASS1-related CBP4 PF07960.11 AMD22801.1 - 1.9e-55 186.2 3.2 2.2e-55 186.0 3.2 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.6 AMD22801.1 - 1.1e-05 25.2 1.5 2.4e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 DUF600 PF04634.12 AMD22801.1 - 0.0052 16.8 0.1 0.0073 16.4 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF600 LAMTOR PF15454.6 AMD22801.1 - 0.057 14.0 1.4 0.057 14.0 1.4 2.1 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Utp11 PF03998.13 AMD22801.1 - 2.1 8.2 13.8 2.6 7.9 4.8 2.0 1 1 1 2 2 2 0 Utp11 protein SE PF08491.10 AMD22802.1 - 4.5e-116 386.7 0.0 5.7e-116 386.4 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 AMD22802.1 - 9.8e-13 48.1 0.0 4.1e-12 46.0 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 AMD22802.1 - 4.1e-06 26.6 0.1 0.0001 22.1 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AMD22802.1 - 0.0034 17.6 0.0 0.007 16.6 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 AMD22802.1 - 0.0045 17.5 0.1 0.016 15.7 0.1 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 AMD22802.1 - 0.0066 16.3 0.1 0.011 15.6 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AMD22802.1 - 0.0071 16.4 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 AMD22802.1 - 0.017 14.2 0.2 0.031 13.4 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 AMD22802.1 - 0.019 14.2 0.2 0.047 12.9 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AMD22802.1 - 0.033 13.5 0.2 0.056 12.8 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase ApbA PF02558.16 AMD22802.1 - 0.051 13.2 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA YoaP PF14268.6 AMD22802.1 - 0.13 11.8 0.2 0.35 10.4 0.2 1.7 1 0 0 1 1 1 0 YoaP-like zf-RRN7 PF11781.8 AMD22803.1 - 7.9e-10 38.3 1.5 1.2e-09 37.6 1.5 1.3 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 LsmAD PF06741.13 AMD22804.1 - 4.3e-28 97.7 0.7 4.3e-28 97.7 0.7 2.2 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.6 AMD22804.1 - 1.4e-14 54.0 0.5 5.5e-14 52.1 0.1 2.3 2 0 0 2 2 2 1 Ataxin 2 SM domain CENP-Q PF13094.6 AMD22805.1 - 0.016 15.4 1.2 0.016 15.4 1.2 2.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Thi4 PF01946.17 AMD22806.1 - 2.6e-105 350.9 0.1 3.1e-105 350.6 0.1 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 AMD22806.1 - 1.6e-06 28.0 1.7 3.2e-06 27.0 0.9 1.7 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AMD22806.1 - 2.6e-06 27.6 0.9 5e-05 23.5 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AMD22806.1 - 3.9e-05 23.7 0.2 0.00021 21.3 0.1 2.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 AMD22806.1 - 4.1e-05 22.8 2.8 0.00078 18.6 1.2 2.1 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 AMD22806.1 - 0.00033 20.1 0.1 0.00048 19.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AMD22806.1 - 0.00074 18.8 0.2 0.0016 17.7 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 AMD22806.1 - 0.00086 18.4 0.5 0.0015 17.7 0.5 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 AMD22806.1 - 0.0087 15.3 0.0 0.018 14.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AMD22806.1 - 0.013 14.2 0.7 0.025 13.3 0.7 1.4 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 AMD22806.1 - 0.034 13.2 0.5 0.1 11.6 0.2 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 AMD22806.1 - 0.082 11.7 0.4 0.12 11.2 0.4 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Ribonuc_red_sm PF00268.21 AMD22807.1 - 1.1e-119 399.1 0.8 1.4e-119 398.7 0.8 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 AMD22807.1 - 0.11 13.3 0.0 0.31 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) Yip1 PF04893.17 AMD22808.1 - 4e-08 33.2 18.1 1.2e-07 31.7 18.1 1.8 1 1 0 1 1 1 1 Yip1 domain DUF5325 PF17259.2 AMD22808.1 - 8.3 6.4 10.0 0.14 12.0 2.3 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5325) MMR_HSR1_Xtn PF16897.5 AMD22809.1 - 1.8e-37 127.6 1.0 3.4e-37 126.7 1.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 AMD22809.1 - 3.3e-22 78.7 0.1 7.5e-22 77.6 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 AMD22809.1 - 7.8e-19 67.5 0.0 1.9e-18 66.3 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AMD22809.1 - 4.8e-13 48.9 0.0 7.9e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AMD22809.1 - 0.00012 22.1 0.2 0.034 14.2 0.0 2.4 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 AMD22809.1 - 0.00059 19.2 0.1 0.00099 18.5 0.1 1.3 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 AMD22809.1 - 0.012 15.1 0.4 0.06 12.8 0.1 2.2 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit Roc PF08477.13 AMD22809.1 - 0.016 15.4 0.2 0.17 12.1 0.0 2.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 AMD22809.1 - 0.049 12.7 0.4 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain Ras PF00071.22 AMD22809.1 - 0.049 13.2 0.5 1.1 8.8 0.1 2.3 2 0 0 2 2 2 0 Ras family AAA_16 PF13191.6 AMD22809.1 - 0.064 13.6 0.3 0.14 12.5 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain RHH_3 PF12651.7 AMD22809.1 - 0.11 12.5 0.1 0.26 11.3 0.1 1.7 1 0 0 1 1 1 0 Ribbon-helix-helix domain tRNA-synt_1g PF09334.11 AMD22810.1 - 2.3e-90 303.2 0.1 3.7e-90 302.5 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AMD22810.1 - 2.7e-21 75.5 0.2 1.6e-10 39.9 0.0 3.8 2 2 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 AMD22810.1 - 8.2e-09 35.2 0.0 0.00028 20.3 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AMD22810.1 - 0.013 14.4 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) DNA_pol_E_B PF04042.16 AMD22811.1 - 7e-37 126.8 0.0 1.2e-36 126.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 AMD22811.1 - 4.7e-34 117.3 0.0 7.4e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Lactamase_B PF00753.27 AMD22811.1 - 0.13 12.3 0.0 0.3 11.1 0.0 1.6 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily PS_Dcarbxylase PF02666.15 AMD22812.1 - 2.7e-56 190.3 0.0 4.5e-56 189.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 AMD22812.1 - 6.8e-22 77.7 0.5 2.6e-13 50.2 0.0 3.5 3 0 0 3 3 3 2 C2 domain HSP20 PF00011.21 AMD22815.1 - 1.7e-13 50.6 0.0 2.3e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AMD22815.1 - 0.012 15.1 0.0 0.064 12.8 0.0 2.0 1 1 0 1 1 1 0 HSP20-like domain found in ArsA Peptidase_M1 PF01433.20 AMD22816.1 - 7.8e-86 287.1 3.7 1.5e-85 286.2 2.3 2.0 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 AMD22816.1 - 6.7e-80 269.0 3.1 4e-79 266.4 0.8 2.3 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 AMD22816.1 - 1.2e-52 178.8 2.7 1.8e-52 178.2 1.7 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain RNase_H2-Ydr279 PF09468.10 AMD22818.1 - 2.8e-14 53.6 0.6 1.4e-13 51.4 0.0 2.3 2 1 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 AMD22818.1 - 4.1e-10 39.8 0.1 6.7e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain RNase_PH PF01138.21 AMD22819.1 - 9.9e-21 74.6 0.0 1.5e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AMD22819.1 - 1.9e-17 63.1 0.3 7.6e-17 61.1 0.1 2.2 3 0 0 3 3 3 1 3' exoribonuclease family, domain 2 Tna_leader PF08053.11 AMD22819.1 - 0.14 12.2 0.4 1.6 8.8 0.1 2.4 2 0 0 2 2 2 0 Tryptophanase operon leader peptide RRM_1 PF00076.22 AMD22820.1 - 1.6e-16 59.8 0.0 9.8e-16 57.3 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RR_TM4-6 PF06459.12 AMD22820.1 - 0.47 10.2 27.0 0.8 9.5 27.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF572 PF04502.13 AMD22820.1 - 1 8.9 26.4 2.2 7.8 26.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF572) Membralin PF09746.9 AMD22820.1 - 1.2 8.1 16.2 0.19 10.7 12.6 1.4 2 0 0 2 2 2 0 Tumour-associated protein PAT1 PF09770.9 AMD22820.1 - 2.4 6.3 57.5 0.026 12.8 49.1 1.9 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF4746 PF15928.5 AMD22820.1 - 2.6 7.4 16.7 4.7 6.6 16.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1682 PF07946.14 AMD22820.1 - 4.7 6.3 14.8 7.6 5.6 14.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) ALMT PF11744.8 AMD22820.1 - 9.2 5.0 22.0 17 4.1 22.0 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S64 PF08192.11 AMD22820.1 - 9.3 4.6 33.0 0.06 11.8 24.5 1.6 2 0 0 2 2 2 0 Peptidase family S64 PNISR PF15996.5 AMD22821.1 - 6 7.1 11.3 23 5.2 6.0 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR RabGAP-TBC PF00566.18 AMD22822.1 - 7.6e-35 120.5 17.2 8.1e-31 107.3 8.1 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain ComK PF06338.11 AMD22822.1 - 0.12 12.0 0.1 0.23 11.1 0.1 1.4 1 0 0 1 1 1 0 ComK protein PAPA-1 PF04795.12 AMD22823.1 - 1.4e-21 77.1 6.6 1.4e-21 77.1 6.6 3.3 2 1 0 3 3 3 1 PAPA-1-like conserved region LIM_bind PF01803.16 AMD22824.1 - 1.6e-62 211.2 0.4 1.6e-62 211.2 0.4 2.9 3 0 0 3 3 3 1 LIM-domain binding protein MTBP_C PF14920.6 AMD22824.1 - 0.01 15.6 1.2 0.01 15.6 1.2 2.3 3 0 0 3 3 3 0 MDM2-binding PRTP PF01366.18 AMD22824.1 - 0.015 13.4 0.0 0.028 12.5 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus processing and transport protein GOLGA2L5 PF15070.6 AMD22824.1 - 2.2 6.9 15.7 2 7.0 0.5 2.1 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Neugrin PF06413.11 AMD22826.1 - 7.7e-09 35.9 0.6 1.4e-08 35.0 0.6 1.6 1 1 0 1 1 1 1 Neugrin Sigma70_r4 PF04545.16 AMD22826.1 - 0.00021 20.7 0.1 0.00045 19.7 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_11 PF08279.12 AMD22826.1 - 0.0027 17.6 0.0 0.0062 16.5 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_32 PF13565.6 AMD22826.1 - 0.012 16.2 0.7 0.093 13.4 0.0 2.4 2 1 0 2 2 2 0 Homeodomain-like domain HSP70 PF00012.20 AMD22827.1 - 8.6e-231 767.3 10.2 9.7e-231 767.1 10.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AMD22827.1 - 9.7e-18 64.1 2.2 2.9e-16 59.2 0.9 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AMD22827.1 - 0.00017 21.4 0.0 0.00039 20.2 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 AMD22827.1 - 0.36 11.3 7.1 4.9 7.6 0.2 3.6 3 2 0 3 3 3 0 Cell division protein FtsA KH_1 PF00013.29 AMD22828.1 - 6.5e-05 22.7 0.2 0.00019 21.2 0.1 1.8 2 0 0 2 2 2 1 KH domain MOEP19 PF16005.5 AMD22828.1 - 0.1 12.6 0.1 0.3 11.1 0.1 1.7 1 0 0 1 1 1 0 KH-like RNA-binding domain Y_phosphatase PF00102.27 AMD22829.1 - 9.7e-52 175.9 0.0 2e-51 174.9 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 AMD22829.1 - 0.00014 21.7 0.1 0.00039 20.3 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AMD22829.1 - 0.028 14.4 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Mrx7 PF10906.8 AMD22830.1 - 2.2e-23 82.3 0.3 2.6e-23 82.1 0.3 1.1 1 0 0 1 1 1 1 MIOREX complex component 7 DUF3225 PF11533.8 AMD22830.1 - 0.084 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3225) VID27 PF08553.10 AMD22831.1 - 6.1e-147 489.3 0.2 1e-146 488.6 0.2 1.3 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 AMD22831.1 - 2.7e-53 180.3 1.3 2.7e-53 180.3 1.3 3.2 3 0 0 3 3 3 1 VID27 N-terminal region VID27_PH PF17747.1 AMD22831.1 - 1.7e-24 86.2 3.5 5.7e-24 84.5 2.1 2.5 3 0 0 3 3 3 1 VID27 PH-like domain ThiF PF00899.21 AMD22832.1 - 2.2e-57 194.2 0.0 3.2e-57 193.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 AMD22832.1 - 2.7e-08 34.3 0.0 7.6e-08 32.8 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 AMD22832.1 - 0.0017 18.4 0.0 0.0061 16.6 0.0 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Herpes_BLRF2 PF05812.12 AMD22832.1 - 0.0056 16.8 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein NAD_binding_7 PF13241.6 AMD22832.1 - 0.015 15.7 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 AMD22832.1 - 0.16 11.5 0.3 0.3 10.7 0.3 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain WD40 PF00400.32 AMD22833.1 - 0.004 18.0 8.8 0.051 14.5 0.2 5.2 7 1 0 7 7 7 1 WD domain, G-beta repeat TruB-C_2 PF09157.11 AMD22833.1 - 0.11 12.5 0.0 0.4 10.7 0.0 1.9 1 0 0 1 1 1 0 Pseudouridine synthase II TruB, C-terminal Rad60-SLD PF11976.8 AMD22834.1 - 1.3e-23 82.6 0.5 4.6e-23 80.8 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 AMD22834.1 - 2.1e-07 30.6 0.8 1e-06 28.4 0.0 2.5 3 0 0 3 3 3 1 Ubiquitin family TUG-UBL1 PF11470.8 AMD22834.1 - 0.026 14.7 0.1 0.075 13.3 0.1 1.8 1 0 0 1 1 1 0 TUG ubiquitin-like domain BBP1_N PF15271.6 AMD22834.1 - 2.7 8.8 11.8 2.3 9.0 8.7 2.4 2 1 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein RNA_pol_Rpb1_5 PF04998.17 AMD22835.1 - 5.9e-82 275.1 0.4 8.4e-82 274.6 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 AMD22835.1 - 2.1e-80 270.4 0.0 5.5e-80 269.0 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 AMD22835.1 - 9.8e-76 253.6 0.0 2e-75 252.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AMD22835.1 - 7.7e-39 133.2 0.2 4.4e-38 130.7 0.0 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 AMD22835.1 - 5.1e-31 106.8 0.0 1.3e-30 105.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DSS1_SEM1 PF05160.13 AMD22836.1 - 9.7e-18 64.0 13.7 1.2e-17 63.8 13.7 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family Tropomyosin_1 PF12718.7 AMD22837.1 - 2e-48 164.1 42.3 2.5e-48 163.9 42.3 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 AMD22837.1 - 1.3e-05 24.7 41.3 1.8e-05 24.2 41.3 1.3 1 0 0 1 1 1 1 Tropomyosin GAS PF13851.6 AMD22837.1 - 1.5e-05 24.5 40.9 1.8e-05 24.2 40.9 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 AMD22837.1 - 4.4e-05 23.5 44.8 0.00033 20.7 7.8 2.4 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 AMD22837.1 - 7.6e-05 23.0 38.4 0.012 15.9 16.6 2.0 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 AMD22837.1 - 0.00066 19.1 14.5 0.00066 19.1 14.5 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 AMD22837.1 - 0.0007 19.8 39.6 0.011 16.0 21.2 3.0 1 1 2 3 3 3 3 TATA element modulatory factor 1 TATA binding Laminin_II PF06009.12 AMD22837.1 - 0.00095 19.2 23.5 0.024 14.7 11.3 2.1 1 1 1 2 2 2 2 Laminin Domain II MscS_porin PF12795.7 AMD22837.1 - 0.002 17.8 23.0 0.002 17.8 23.0 2.0 1 1 1 2 2 2 1 Mechanosensitive ion channel porin domain BLOC1_2 PF10046.9 AMD22837.1 - 0.0027 18.0 29.6 0.17 12.2 9.3 3.2 1 1 1 3 3 3 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 ZapB PF06005.12 AMD22837.1 - 0.0028 18.1 50.3 0.89 10.0 4.2 3.9 2 1 1 3 3 3 2 Cell division protein ZapB ADIP PF11559.8 AMD22837.1 - 0.0041 17.2 35.3 0.12 12.4 15.1 2.7 1 1 2 3 3 3 3 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 AMD22837.1 - 0.0044 17.0 20.3 0.014 15.5 6.7 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Lebercilin PF15619.6 AMD22837.1 - 0.0053 16.4 37.6 0.0068 16.1 37.6 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Cast PF10174.9 AMD22837.1 - 0.0062 14.8 29.5 0.0068 14.7 29.5 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Uso1_p115_C PF04871.13 AMD22837.1 - 0.0076 16.6 41.3 0.35 11.2 15.8 2.1 1 1 1 2 2 2 2 Uso1 / p115 like vesicle tethering protein, C terminal region TPR_MLP1_2 PF07926.12 AMD22837.1 - 0.0097 16.0 44.0 0.15 12.1 15.1 3.3 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 AMD22837.1 - 0.013 15.2 33.4 0.15 11.8 25.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) MbeD_MobD PF04899.12 AMD22837.1 - 0.015 15.4 14.4 0.024 14.7 1.4 3.1 1 1 2 3 3 3 0 MbeD/MobD like KIP1 PF07765.12 AMD22837.1 - 0.016 15.3 7.6 0.016 15.3 7.6 3.5 1 1 2 3 3 3 0 KIP1-like protein CLZ PF16526.5 AMD22837.1 - 0.017 15.5 32.4 0.19 12.1 2.4 3.7 1 1 3 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels KASH_CCD PF14662.6 AMD22837.1 - 0.019 14.8 43.6 0.051 13.4 27.7 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TMF_DNA_bd PF12329.8 AMD22837.1 - 0.019 14.9 21.3 0.019 14.9 21.3 3.2 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 AMD22837.1 - 0.023 13.6 39.5 0.34 9.7 24.6 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 AMD22837.1 - 0.024 14.7 38.5 5 7.3 3.8 4.7 1 1 4 5 5 5 0 bZIP transcription factor Filament PF00038.21 AMD22837.1 - 0.034 13.7 33.6 0.2 11.2 14.4 1.9 1 1 1 2 2 2 0 Intermediate filament protein DUF4200 PF13863.6 AMD22837.1 - 0.039 14.3 40.4 1 9.8 17.3 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 AMD22837.1 - 0.065 13.8 50.6 0.82 10.2 26.6 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region KLRAQ PF10205.9 AMD22837.1 - 0.069 13.4 30.8 0.88 9.9 9.1 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Spc24 PF08286.11 AMD22837.1 - 0.07 13.4 37.9 0.47 10.7 13.6 4.0 1 1 3 4 4 4 0 Spc24 subunit of Ndc80 Lectin_N PF03954.14 AMD22837.1 - 0.077 12.7 20.4 0.1 12.3 9.9 2.8 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain HMMR_C PF15908.5 AMD22837.1 - 0.082 13.2 27.0 0.19 12.0 2.0 3.6 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Mod_r PF07200.13 AMD22837.1 - 0.097 12.8 38.4 1.9 8.6 37.6 3.1 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein FlaC_arch PF05377.11 AMD22837.1 - 0.098 13.1 27.9 0.54 10.7 0.4 4.7 1 1 4 5 5 5 0 Flagella accessory protein C (FlaC) Spectrin PF00435.21 AMD22837.1 - 0.099 13.1 32.0 1.2 9.7 13.1 3.1 1 1 2 3 3 3 0 Spectrin repeat DUF4686 PF15742.5 AMD22837.1 - 0.1 11.7 39.6 0.2 10.7 39.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) IFT57 PF10498.9 AMD22837.1 - 0.11 11.4 32.6 0.2 10.6 32.6 1.4 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 OmpH PF03938.14 AMD22837.1 - 0.13 12.6 36.1 0.13 12.6 13.6 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) P22_Tail-4 PF11650.8 AMD22837.1 - 0.14 12.1 1.8 0.18 11.7 0.1 1.9 2 0 0 2 2 2 0 P22 tail accessory factor ERM PF00769.19 AMD22837.1 - 0.14 12.0 41.8 0.31 10.8 32.0 1.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family HOOK PF05622.12 AMD22837.1 - 0.16 10.1 33.7 0.22 9.6 33.7 1.3 1 0 0 1 1 1 0 HOOK protein DHR10 PF18595.1 AMD22837.1 - 0.25 11.4 40.4 0.7 10.0 12.7 2.5 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain EzrA PF06160.12 AMD22837.1 - 0.27 9.3 34.5 0.21 9.7 13.8 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA FPP PF05911.11 AMD22837.1 - 0.3 9.2 38.6 0.63 8.2 38.5 1.5 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil DUF4472 PF14739.6 AMD22837.1 - 0.32 11.7 32.5 0.93 10.3 2.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Prefoldin_2 PF01920.20 AMD22837.1 - 0.34 10.9 44.4 0.62 10.0 3.0 4.1 1 1 3 4 4 4 0 Prefoldin subunit CALCOCO1 PF07888.11 AMD22837.1 - 0.37 9.6 36.1 0.43 9.4 36.1 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like SHE3 PF17078.5 AMD22837.1 - 0.39 10.4 31.4 0.8 9.4 31.3 1.7 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_2 PF07716.15 AMD22837.1 - 0.4 10.8 38.3 1.9 8.6 2.0 4.8 3 2 1 4 4 4 0 Basic region leucine zipper WXG100 PF06013.12 AMD22837.1 - 0.54 10.5 15.7 23 5.3 0.8 4.1 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Sec34 PF04136.15 AMD22837.1 - 0.55 10.1 26.5 0.53 10.2 14.9 2.1 1 1 1 2 2 2 0 Sec34-like family Ax_dynein_light PF10211.9 AMD22837.1 - 0.6 10.0 38.4 0.49 10.3 3.2 3.3 1 1 2 3 3 3 0 Axonemal dynein light chain PspA_IM30 PF04012.12 AMD22837.1 - 0.64 9.6 29.0 1.2 8.7 29.0 1.6 1 1 0 1 1 1 0 PspA/IM30 family DUF5082 PF16888.5 AMD22837.1 - 0.76 10.1 26.8 1.3 9.3 0.6 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) MPS2 PF17060.5 AMD22837.1 - 0.82 8.9 28.2 0.16 11.2 9.7 2.8 1 1 0 2 2 2 0 Monopolar spindle protein 2 HetR_C PF18460.1 AMD22837.1 - 0.82 9.6 11.0 0.12 12.3 0.7 3.3 1 1 3 4 4 4 0 Heterocyst differentiation regulator C-terminal Hood domain Leu_zip PF15294.6 AMD22837.1 - 0.87 9.1 32.2 2.5 7.5 32.2 1.7 1 1 0 1 1 1 0 Leucine zipper DUF724 PF05266.14 AMD22837.1 - 0.87 9.4 31.2 3.3 7.5 12.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Fzo_mitofusin PF04799.13 AMD22837.1 - 1 8.9 22.8 0.46 10.0 7.5 2.8 1 1 1 2 2 2 0 fzo-like conserved region DivIC PF04977.15 AMD22837.1 - 1 9.2 36.9 8 6.3 3.2 4.2 1 1 3 4 4 4 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 AMD22837.1 - 1.1 9.5 43.5 0.89 9.8 27.1 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 XhlA PF10779.9 AMD22837.1 - 1.2 9.4 32.9 2.2 8.5 0.3 3.9 2 1 0 3 3 3 0 Haemolysin XhlA Fez1 PF06818.15 AMD22837.1 - 1.2 9.5 33.5 2.3 8.6 31.2 1.9 1 1 1 2 2 2 0 Fez1 GrpE PF01025.19 AMD22837.1 - 1.2 8.7 39.2 0.07 12.8 3.4 3.7 1 1 2 3 3 2 0 GrpE PI3K_P85_iSH2 PF16454.5 AMD22837.1 - 1.5 8.4 35.2 2.5 7.7 2.9 3.2 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FliD_C PF07195.12 AMD22837.1 - 1.5 8.2 20.8 1.4 8.2 0.8 3.1 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus HAP1_N PF04849.13 AMD22837.1 - 1.9 7.7 42.6 8.1 5.6 41.9 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Taxilin PF09728.9 AMD22837.1 - 1.9 7.6 42.0 0.59 9.3 16.9 2.5 1 1 1 2 2 2 0 Myosin-like coiled-coil protein LPP PF04728.13 AMD22837.1 - 1.9 8.9 13.0 10 6.6 0.8 3.8 2 1 2 4 4 4 0 Lipoprotein leucine-zipper DUF3584 PF12128.8 AMD22837.1 - 2 5.9 30.4 2.7 5.4 30.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MIS13 PF08202.11 AMD22837.1 - 2 7.6 29.5 18 4.5 6.6 2.2 1 1 1 2 2 2 0 Mis12-Mtw1 protein family CENP-K PF11802.8 AMD22837.1 - 2.1 7.8 36.8 4 6.9 17.7 2.1 1 1 1 2 2 2 0 Centromere-associated protein K Phage_GP20 PF06810.11 AMD22837.1 - 2.5 7.9 34.1 0.97 9.2 14.9 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF2203 PF09969.9 AMD22837.1 - 2.5 8.8 23.7 4.5 8.0 8.9 2.9 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) TACC_C PF05010.14 AMD22837.1 - 2.6 7.8 35.5 0.69 9.7 2.8 2.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Swi5 PF07061.11 AMD22837.1 - 2.8 8.1 36.2 1.4 9.1 7.5 4.1 1 1 3 4 4 4 0 Swi5 Fib_alpha PF08702.10 AMD22837.1 - 3.1 8.0 23.2 2.2 8.5 14.3 2.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Fmp27_WPPW PF10359.9 AMD22837.1 - 3.1 6.5 29.2 1.3 7.8 19.8 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF812 PF05667.11 AMD22837.1 - 3.2 6.5 37.0 1.1 8.0 21.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Seryl_tRNA_N PF02403.22 AMD22837.1 - 3.3 8.0 32.3 6.5 7.0 0.8 3.2 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Alpha-2-MRAP_C PF06401.11 AMD22837.1 - 3.5 7.5 34.8 6.3 6.7 34.8 1.4 1 1 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain YabA PF06156.13 AMD22837.1 - 4.2 8.0 33.1 1.8e+04 -6.7 33.1 3.1 1 1 0 1 1 0 0 Initiation control protein YabA AAA_13 PF13166.6 AMD22837.1 - 4.5 5.8 30.9 2 7.0 13.3 1.9 1 1 0 1 1 1 0 AAA domain Fungal_TACC PF12709.7 AMD22837.1 - 4.5 7.8 37.2 1 9.9 5.8 4.1 2 1 2 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins HemX PF04375.14 AMD22837.1 - 4.8 6.4 27.4 2.8 7.1 11.8 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF3287 PF11690.8 AMD22837.1 - 4.9 6.9 11.0 3.1 7.5 0.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3287) Snapin_Pallidin PF14712.6 AMD22837.1 - 5.1 7.6 26.7 3.3 8.2 7.1 3.3 1 1 2 3 3 3 0 Snapin/Pallidin Dynamitin PF04912.14 AMD22837.1 - 5.3 6.3 31.6 2.5 7.4 28.3 1.8 1 1 1 2 2 2 0 Dynamitin HAUS6_N PF14661.6 AMD22837.1 - 5.8 6.4 25.6 1.7 8.2 8.2 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF5595 PF18077.1 AMD22837.1 - 6.2 7.0 32.3 0.17 12.0 11.0 3.7 2 2 2 4 4 4 0 Domain of unknown function (DUF5595) T2SSM PF04612.12 AMD22837.1 - 6.4 6.8 14.2 0.39 10.8 2.9 2.9 1 1 2 3 3 3 0 Type II secretion system (T2SS), protein M UPF0242 PF06785.11 AMD22837.1 - 6.7 6.8 42.8 0.96 9.5 19.6 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 AMD22837.1 - 9 5.3 30.3 3.1 6.8 21.9 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 EOS1 PF12326.8 AMD22838.1 - 5e-61 205.7 7.2 8.2e-61 205.0 7.2 1.3 1 0 0 1 1 1 1 N-glycosylation protein Ribosomal_S13 PF00416.22 AMD22839.1 - 5.1e-17 62.5 0.0 7.4e-15 55.5 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 AMD22839.1 - 0.055 12.2 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DNA_mis_repair PF01119.19 AMD22840.1 - 3.3e-26 91.3 1.3 8.6e-26 90.0 0.0 2.3 3 0 0 3 3 3 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.11 AMD22840.1 - 5.5e-25 87.9 0.0 1.2e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.6 AMD22840.1 - 2.2e-13 50.2 0.1 1.1e-12 47.9 0.1 2.2 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AMD22840.1 - 0.00039 20.9 0.3 0.0016 19.0 0.0 2.2 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Carot_N PF09150.10 AMD22840.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal HORMA PF02301.18 AMD22841.1 - 2.9e-09 36.8 0.1 3.8e-09 36.4 0.1 1.3 1 1 0 1 1 1 1 HORMA domain RBD-FIP PF09457.10 AMD22841.1 - 0.009 15.9 2.5 0.057 13.3 0.2 3.2 3 0 0 3 3 3 1 FIP domain Mito_carr PF00153.27 AMD22842.1 - 2.4e-62 206.9 2.8 8.9e-21 73.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 AMD22842.1 - 1.5e-14 52.4 2.6 0.0022 17.4 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 AMD22842.1 - 2.1e-14 52.1 2.2 0.013 15.4 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 AMD22842.1 - 2.8e-10 40.5 4.0 1.1e-05 25.8 0.5 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 AMD22842.1 - 1.1e-07 31.0 3.9 0.00012 21.4 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 AMD22842.1 - 0.00025 20.8 0.3 0.022 14.6 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 AMD22842.1 - 0.0083 16.4 0.1 0.72 10.2 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 AMD22842.1 - 0.013 15.9 0.3 0.034 14.5 0.3 1.8 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region 4HBT PF03061.22 AMD22843.1 - 0.00039 20.7 0.1 1.6 9.1 0.1 2.9 2 1 1 3 3 3 2 Thioesterase superfamily He_PIG PF05345.12 AMD22844.1 - 2.5e-06 27.6 2.3 0.0082 16.3 0.0 4.1 4 0 0 4 4 4 2 Putative Ig domain MRAP PF15183.6 AMD22844.1 - 0.13 12.2 0.0 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family EF-hand_4 PF12763.7 AMD22845.1 - 8.9e-49 163.8 6.9 1.3e-48 163.3 1.6 2.7 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand End3 PF12761.7 AMD22845.1 - 8.1e-39 133.9 10.5 2.6e-38 132.2 10.5 1.8 1 1 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_1 PF00036.32 AMD22845.1 - 0.0059 16.1 2.0 0.023 14.2 2.0 2.1 1 0 0 1 1 1 1 EF hand Fib_alpha PF08702.10 AMD22845.1 - 0.038 14.2 5.9 0.087 13.0 5.9 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 AMD22845.1 - 0.61 10.5 4.2 4.1 7.9 0.1 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 AMD22845.1 - 0.65 10.3 5.5 3.7 7.9 0.1 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4094 PF13334.6 AMD22845.1 - 0.8 10.2 7.6 0.75 10.3 2.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) ABC_tran_CTD PF16326.5 AMD22845.1 - 2 8.7 7.6 8.2 6.8 1.0 2.5 1 1 2 3 3 3 0 ABC transporter C-terminal domain GrpE PF01025.19 AMD22845.1 - 4.7 6.9 8.7 7.8 6.1 0.2 2.3 1 1 1 2 2 2 0 GrpE FlxA PF14282.6 AMD22845.1 - 5.5 7.0 23.3 0.03 14.3 7.0 3.2 1 1 2 3 3 3 0 FlxA-like protein Cpn60_TCP1 PF00118.24 AMD22846.1 - 5.1e-151 503.6 9.8 5.8e-151 503.4 9.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-ANAPC11 PF12861.7 AMD22847.1 - 1.9e-41 140.0 6.9 2.5e-41 139.6 6.9 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 AMD22847.1 - 1.9e-20 72.9 12.0 1.9e-20 72.9 12.0 1.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AMD22847.1 - 1.9e-05 24.9 22.4 3.1e-05 24.2 18.5 2.8 2 1 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.6 AMD22847.1 - 0.0014 18.6 13.4 0.043 13.8 14.5 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AMD22847.1 - 0.0084 16.1 11.5 0.031 14.3 8.1 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 AMD22847.1 - 0.0098 15.7 15.0 0.013 15.3 2.1 3.2 2 1 1 3 3 3 1 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 AMD22847.1 - 0.011 15.3 6.7 0.011 15.3 6.7 2.2 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 AMD22847.1 - 0.048 13.5 17.6 0.45 10.4 17.6 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD22847.1 - 0.051 13.4 17.6 0.29 11.0 14.8 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Coleoptericin PF06286.11 AMD22847.1 - 0.15 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Coleoptericin Beta_helix_2 PF18835.1 AMD22847.1 - 0.18 11.6 0.1 0.29 10.9 0.1 1.2 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase zf-C3HC4_3 PF13920.6 AMD22847.1 - 0.19 11.6 14.0 0.47 10.4 9.3 2.4 1 1 2 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.6 AMD22847.1 - 0.25 11.5 8.8 0.13 12.4 5.6 2.0 1 1 1 2 2 2 0 PHD-zinc-finger like domain zf-HIT PF04438.16 AMD22847.1 - 0.57 10.1 9.8 0.18 11.7 5.2 2.2 2 0 0 2 2 2 0 HIT zinc finger FANCL_C PF11793.8 AMD22847.1 - 0.78 10.0 20.5 4.6 7.5 17.9 3.6 2 1 0 2 2 2 0 FANCL C-terminal domain zf-HC5HC2H PF13771.6 AMD22847.1 - 2.3 8.5 10.7 7.8 6.8 10.3 2.1 1 1 1 2 2 2 0 PHD-like zinc-binding domain Opy2 PF09463.10 AMD22847.1 - 2.5 8.5 12.1 0.44 10.9 6.6 2.2 2 0 0 2 2 2 0 Opy2 protein zf-RING-like PF08746.11 AMD22847.1 - 2.5 8.5 13.0 5.3 7.4 11.3 2.3 1 1 1 2 2 2 0 RING-like domain Glutaredoxin PF00462.24 AMD22848.1 - 3.4e-11 43.2 0.0 7.3e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 AMD22848.1 - 0.022 15.2 0.0 0.039 14.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Mannosyl_trans3 PF11051.8 AMD22849.1 - 2.6e-76 256.6 0.0 6.7e-76 255.2 0.0 1.6 2 0 0 2 2 2 1 Mannosyltransferase putative ATP19 PF11022.8 AMD22850.1 - 1.1e-21 76.9 0.0 1.2e-21 76.8 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K Rsm22 PF09243.10 AMD22850.1 - 0.0086 15.4 0.0 0.0092 15.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 UPF0254 PF06787.11 AMD22850.1 - 0.037 13.8 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) Brix PF04427.18 AMD22851.1 - 8.2e-41 140.2 0.2 1.2e-40 139.7 0.2 1.2 1 0 0 1 1 1 1 Brix domain Peptidase_M11 PF05548.11 AMD22851.1 - 0.09 11.9 0.1 0.15 11.2 0.1 1.3 1 0 0 1 1 1 0 Gametolysin peptidase M11 NatB_MDM20 PF09797.9 AMD22852.1 - 2.9e-43 148.3 5.8 5.5e-43 147.4 2.7 2.4 2 1 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit DUF445 PF04286.12 AMD22852.1 - 0.28 10.9 1.7 6 6.6 0.9 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF445) SNRNP27 PF08648.12 AMD22853.1 - 1.7 8.8 4.7 4.3 7.5 4.7 1.7 1 0 0 1 1 1 0 U4/U6.U5 small nuclear ribonucleoproteins CRIM PF16978.5 AMD22854.1 - 4.2e-33 114.5 0.5 3.7e-32 111.4 0.1 2.5 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 AMD22854.1 - 1.9e-29 102.1 0.3 5.5e-29 100.7 0.3 1.8 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 AMD22854.1 - 7e-05 23.0 0.3 0.0012 19.0 0.1 2.8 2 0 0 2 2 2 1 TUG ubiquitin-like domain RBD PF02196.15 AMD22854.1 - 0.028 14.5 0.0 0.11 12.6 0.0 1.9 2 0 0 2 2 2 0 Raf-like Ras-binding domain RNase_T PF00929.24 AMD22855.1 - 1.3e-17 64.8 0.0 3e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 AMD22855.1 - 0.00096 18.9 0.0 0.009 15.7 0.0 2.4 1 1 0 1 1 1 1 3'-5' exonuclease DUF5051 PF16473.5 AMD22855.1 - 0.034 14.1 0.0 0.089 12.8 0.0 1.8 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like RasGAP PF00616.19 AMD22856.1 - 3.9e-22 79.0 0.0 1.6e-16 60.6 0.0 3.1 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase Consortin_C PF15281.6 AMD22856.1 - 0.048 13.7 0.0 0.17 11.9 0.0 1.9 1 0 0 1 1 1 0 Consortin C-terminus Bmt2 PF11968.8 AMD22857.1 - 4.9e-83 278.3 0.1 6.6e-83 277.9 0.1 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_12 PF08242.12 AMD22857.1 - 0.094 13.5 0.0 0.24 12.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DEAD PF00270.29 AMD22858.1 - 7.5e-40 136.6 0.0 1.7e-39 135.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22858.1 - 5.1e-31 107.3 0.6 3.4e-28 98.2 0.0 3.2 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 AMD22858.1 - 7e-07 29.4 0.1 1.7e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NACHT PF05729.12 AMD22858.1 - 0.033 14.1 0.3 0.15 12.0 0.0 2.2 2 1 0 2 2 2 0 NACHT domain DUF2255 PF10012.9 AMD22858.1 - 0.3 11.2 0.0 0.3 11.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2255) AAA_22 PF13401.6 AMD22858.1 - 0.5 10.6 4.0 2 8.7 0.7 3.2 2 2 0 2 2 2 0 AAA domain FAM176 PF14851.6 AMD22858.1 - 0.63 9.7 7.4 2.1 8.0 7.4 2.0 1 0 0 1 1 1 0 FAM176 family eRF1_2 PF03464.15 AMD22859.1 - 5.5e-47 159.4 0.1 1e-46 158.5 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 AMD22859.1 - 1.1e-38 132.2 0.5 2.5e-38 131.0 0.5 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 AMD22859.1 - 5.6e-20 71.6 0.0 1e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 AMD22859.1 - 1.3e-10 41.6 0.1 2.1e-10 41.0 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 AMD22859.1 - 1.6e-08 34.9 0.0 2.9e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 ATG19_autophagy PF12744.7 AMD22860.1 - 2.3e-23 82.7 3.8 2.3e-23 82.7 3.8 2.0 3 0 0 3 3 3 1 Autophagy protein Atg19, Atg8-binding ZZ PF00569.17 AMD22860.1 - 8.4e-08 31.9 35.3 9e-06 25.4 9.8 4.7 4 1 0 4 4 4 2 Zinc finger, ZZ type Tenui_NCP PF04876.12 AMD22860.1 - 0.12 11.9 1.3 0.17 11.4 0.2 1.8 2 0 0 2 2 2 0 Tenuivirus major non-capsid protein RSN1_7TM PF02714.15 AMD22861.1 - 1e-83 280.8 24.7 1e-83 280.8 24.7 2.4 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AMD22861.1 - 7.2e-37 126.6 3.2 7.2e-37 126.6 3.2 3.7 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AMD22861.1 - 4.9e-26 92.0 0.1 7.4e-26 91.4 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 AMD22861.1 - 3.3e-15 56.0 0.1 1e-14 54.5 0.0 1.9 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter Spore_YtrH PF14034.6 AMD22861.1 - 0.081 13.1 0.3 0.19 11.9 0.3 1.6 1 0 0 1 1 1 0 Sporulation protein YtrH RRM_1 PF00076.22 AMD22861.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gp_dh_C PF02800.20 AMD22862.1 - 7.3e-71 236.9 0.0 2.4e-70 235.2 0.0 1.8 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 AMD22862.1 - 2.7e-39 133.6 0.2 6.5e-39 132.3 0.0 1.7 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 AMD22862.1 - 0.0063 16.6 0.7 0.02 15.0 0.1 2.2 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus ADH_N PF08240.12 AMD22863.1 - 4.6e-29 100.5 0.9 7.9e-29 99.7 0.2 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AMD22863.1 - 8e-28 97.0 1.2 1.3e-27 96.3 1.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AMD22863.1 - 1.1e-05 26.5 0.1 1.8e-05 25.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DapB_N PF01113.20 AMD22863.1 - 0.092 12.9 0.5 0.19 11.8 0.5 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Ribosomal_S9 PF00380.19 AMD22864.1 - 1.1e-43 148.6 0.4 1.9e-43 147.8 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CENP-S PF15630.6 AMD22865.1 - 2.2e-25 88.8 0.0 2.8e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 AMD22865.1 - 5.1e-06 26.6 0.0 6.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold DUF3337 PF11816.8 AMD22866.1 - 1.8e-32 112.6 0.6 4e-32 111.4 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 AMD22866.1 - 0.0057 17.5 6.2 1.2 10.1 0.0 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat RAWUL PF16207.5 AMD22866.1 - 0.025 15.2 0.1 0.077 13.7 0.0 1.9 2 0 0 2 2 2 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like RNA_pol_Rpb5_C PF01191.19 AMD22867.1 - 2e-32 110.9 0.4 3.7e-32 110.0 0.4 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 AMD22867.1 - 1.5e-29 102.4 0.2 3.1e-29 101.4 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Sof1 PF04158.14 AMD22867.1 - 0.015 15.6 0.3 0.028 14.7 0.3 1.4 1 0 0 1 1 1 0 Sof1-like domain RibD_C PF01872.17 AMD22868.1 - 4.5e-30 105.0 0.0 5.1e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain MFAP1 PF06991.11 AMD22869.1 - 1.7e-05 24.8 11.4 1.7e-05 24.8 11.4 1.8 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Thioredoxin PF00085.20 AMD22870.1 - 5e-15 55.4 0.1 2.3e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 AMD22870.1 - 0.0036 17.6 0.0 0.0079 16.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 AMD22870.1 - 0.019 15.4 0.1 0.041 14.3 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Suc_Fer-like PF06999.12 AMD22871.1 - 1.5e-47 162.0 0.0 1.9e-47 161.7 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Synapsin_C PF02750.14 AMD22871.1 - 0.15 11.5 0.1 0.97 8.9 0.0 2.0 2 0 0 2 2 2 0 Synapsin, ATP binding domain Phage_GP20 PF06810.11 AMD22873.1 - 7.1e-06 25.9 11.0 3.4e-05 23.7 10.3 2.2 1 1 1 2 2 2 1 Phage minor structural protein GP20 HMMR_N PF15905.5 AMD22873.1 - 0.00062 19.4 13.3 0.0012 18.5 13.3 1.5 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal ApoLp-III PF07464.11 AMD22873.1 - 0.0024 18.0 7.2 0.0047 17.0 7.2 1.4 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Spc7 PF08317.11 AMD22873.1 - 0.0025 16.8 14.7 0.0072 15.2 14.5 1.9 1 1 0 1 1 1 1 Spc7 kinetochore protein OmpH PF03938.14 AMD22873.1 - 0.0038 17.6 10.5 0.0038 17.6 10.5 1.6 2 0 0 2 2 1 1 Outer membrane protein (OmpH-like) HAUS-augmin3 PF14932.6 AMD22873.1 - 0.0041 16.8 9.4 0.0062 16.1 9.4 1.4 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 Mod_r PF07200.13 AMD22873.1 - 0.0041 17.2 13.4 0.41 10.8 2.2 2.3 1 1 1 2 2 2 2 Modifier of rudimentary (Mod(r)) protein FAM76 PF16046.5 AMD22873.1 - 0.0055 16.1 13.6 0.009 15.4 13.6 1.3 1 0 0 1 1 1 1 FAM76 protein APG6_N PF17675.1 AMD22873.1 - 0.012 16.1 15.0 0.22 12.0 4.6 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Cep57_MT_bd PF06657.13 AMD22873.1 - 0.019 15.4 3.6 0.019 15.4 3.6 2.8 2 1 1 3 3 2 0 Centrosome microtubule-binding domain of Cep57 CortBP2 PF09727.9 AMD22873.1 - 0.021 14.7 2.4 0.021 14.7 2.4 2.5 1 1 1 2 2 2 0 Cortactin-binding protein-2 bZIP_1 PF00170.21 AMD22873.1 - 0.034 14.2 12.7 0.13 12.4 0.1 3.9 2 1 1 4 4 4 0 bZIP transcription factor CALCOCO1 PF07888.11 AMD22873.1 - 0.039 12.8 12.5 0.061 12.2 12.5 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Csm1_N PF18504.1 AMD22873.1 - 0.042 14.2 1.8 0.042 14.2 1.8 3.1 1 1 1 2 2 2 0 Csm1 N-terminal domain Exonuc_VII_L PF02601.15 AMD22873.1 - 0.055 13.0 7.6 0.073 12.6 7.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit KASH_CCD PF14662.6 AMD22873.1 - 0.098 12.5 15.2 0.18 11.6 14.9 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 AMD22873.1 - 0.11 12.6 17.6 0.59 10.2 8.5 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 AMD22873.1 - 0.13 12.5 16.7 0.026 14.7 12.8 1.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 AMD22873.1 - 0.13 12.4 17.4 0.27 11.3 16.8 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus YkyA PF10368.9 AMD22873.1 - 0.13 11.9 11.1 0.47 10.1 10.8 2.1 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein TMF_DNA_bd PF12329.8 AMD22873.1 - 0.14 12.1 11.8 0.38 10.8 2.3 2.8 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.8 AMD22873.1 - 0.16 11.3 17.4 0.41 9.9 11.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HAP1_N PF04849.13 AMD22873.1 - 0.16 11.1 15.7 0.23 10.6 15.7 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Fib_alpha PF08702.10 AMD22873.1 - 0.19 11.9 14.2 0.54 10.4 11.6 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family YojJ PF10372.9 AMD22873.1 - 0.2 11.8 3.3 3.3 7.9 0.1 3.1 1 1 3 4 4 4 0 Bacterial membrane-spanning protein N-terminus KELK PF15796.5 AMD22873.1 - 0.23 11.9 11.2 0.32 11.5 9.1 2.3 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Prefoldin_2 PF01920.20 AMD22873.1 - 0.24 11.4 13.1 1.3 9.0 4.0 2.8 2 0 0 2 2 2 0 Prefoldin subunit DUF641 PF04859.12 AMD22873.1 - 0.24 11.7 9.8 0.35 11.2 2.5 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Filament PF00038.21 AMD22873.1 - 0.26 10.8 15.8 0.15 11.6 6.7 2.1 1 1 1 2 2 2 0 Intermediate filament protein SlyX PF04102.12 AMD22873.1 - 0.28 11.8 11.8 2.8 8.6 2.1 2.8 1 1 1 2 2 2 0 SlyX FliJ PF02050.16 AMD22873.1 - 0.28 11.4 10.9 0.8 9.9 1.3 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein STAT_alpha PF01017.20 AMD22873.1 - 0.3 10.9 14.8 0.39 10.6 13.2 1.9 1 1 1 2 2 2 0 STAT protein, all-alpha domain ATG16 PF08614.11 AMD22873.1 - 0.34 11.1 21.0 16 5.7 12.2 3.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Lebercilin PF15619.6 AMD22873.1 - 0.36 10.5 17.8 0.083 12.5 13.3 2.1 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 AMD22873.1 - 0.38 10.8 9.2 1.4 9.0 2.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 AMD22873.1 - 0.38 10.8 18.0 1.2 9.2 6.4 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 AMD22873.1 - 0.4 10.4 15.9 0.12 12.1 8.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Laminin_II PF06009.12 AMD22873.1 - 0.51 10.4 9.6 1.3 9.1 9.6 1.7 1 0 0 1 1 1 0 Laminin Domain II FUSC PF04632.12 AMD22873.1 - 0.54 8.7 0.8 0.7 8.4 0.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family YabA PF06156.13 AMD22873.1 - 0.82 10.3 14.6 6.9 7.4 6.3 3.8 2 1 2 4 4 3 0 Initiation control protein YabA DUF948 PF06103.11 AMD22873.1 - 0.92 9.8 8.9 0.38 11.1 3.2 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Tropomyosin_1 PF12718.7 AMD22873.1 - 0.94 9.6 13.1 1 9.5 11.6 1.8 1 1 0 1 1 1 0 Tropomyosin like ZapB PF06005.12 AMD22873.1 - 1.2 9.6 18.3 4.3 7.9 6.0 3.3 1 1 2 3 3 3 0 Cell division protein ZapB CREPT PF16566.5 AMD22873.1 - 1.2 9.2 10.8 1 9.5 2.8 2.5 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour CENP-F_leu_zip PF10473.9 AMD22873.1 - 1.3 9.1 15.4 4.6 7.2 15.4 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 AMD22873.1 - 1.5 8.1 9.1 2.4 7.4 9.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tweety PF04906.13 AMD22873.1 - 1.5 7.4 3.7 2.2 6.9 3.7 1.2 1 0 0 1 1 1 0 Tweety LMBR1 PF04791.16 AMD22873.1 - 2 7.2 8.1 2.3 7.1 8.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Swi5 PF07061.11 AMD22873.1 - 2.9 8.1 8.6 1.7 8.8 0.5 2.8 2 1 0 2 2 2 0 Swi5 FlaC_arch PF05377.11 AMD22873.1 - 5.6 7.4 7.0 31 5.1 1.9 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Spc24 PF08286.11 AMD22873.1 - 7.4 6.9 14.3 2.2e+03 -1.1 14.3 3.0 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF724 PF05266.14 AMD22873.1 - 7.8 6.3 13.1 4.1 7.2 10.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) CBM_21 PF03370.13 AMD22874.1 - 1.6e-25 89.5 5.8 3.9e-25 88.2 5.8 1.7 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 AMD22874.1 - 0.00046 20.7 6.6 0.004 17.7 6.6 2.4 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) MCM PF00493.23 AMD22875.1 - 8.4e-103 342.3 0.1 1.9e-102 341.1 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 AMD22875.1 - 2.4e-36 124.4 0.1 4.6e-36 123.5 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AMD22875.1 - 5.4e-28 97.2 2.9 1.5e-27 95.8 2.9 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AMD22875.1 - 1.1e-15 58.1 0.3 3.2e-15 56.6 0.1 1.9 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 AMD22875.1 - 5.7e-06 26.4 0.0 1.5e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AMD22875.1 - 2.6e-05 23.7 0.0 0.0043 16.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AMD22875.1 - 0.0016 18.3 0.0 0.0054 16.6 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AMD22875.1 - 0.015 15.0 0.0 0.46 10.2 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Imm35 PF15567.6 AMD22875.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 35 LSM PF01423.22 AMD22876.1 - 4e-18 64.9 0.4 5.4e-18 64.4 0.4 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AMD22876.1 - 0.019 14.6 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Hfq protein DuffyBP_N PF12377.8 AMD22876.1 - 0.18 12.2 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 Duffy binding protein N terminal DEAD PF00270.29 AMD22877.1 - 3.5e-36 124.6 0.3 6e-36 123.9 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AMD22877.1 - 1.5e-31 109.0 0.1 6.7e-31 106.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD22877.1 - 6.5e-05 23.0 0.8 0.00024 21.2 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Microtub_bind PF13931.6 AMD22877.1 - 6 7.3 8.1 5.5 7.4 0.8 3.3 2 1 0 2 2 2 0 Kinesin-associated microtubule-binding CPSF73-100_C PF11718.8 AMD22878.1 - 3.8e-55 186.8 0.7 7.1e-55 185.9 0.7 1.5 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 AMD22878.1 - 1.7e-30 105.5 0.0 4.4e-30 104.2 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 AMD22878.1 - 2.2e-21 76.8 0.3 3.3e-21 76.2 0.3 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 AMD22878.1 - 4.7e-20 71.9 0.0 1.2e-19 70.6 0.0 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 AMD22878.1 - 5.3e-18 64.7 0.0 1.2e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 AMD22878.1 - 1.2e-07 31.5 0.2 3.1e-06 26.8 0.2 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AMD22878.1 - 2.8e-05 24.1 0.0 0.00011 22.1 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 AMD22878.1 - 0.026 13.7 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative beta-lactamase-like family Fungal_trans PF04082.18 AMD22879.1 - 3.3e-17 62.4 0.9 7.9e-17 61.2 0.9 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD22879.1 - 0.00064 19.8 10.6 0.00064 19.8 10.6 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RF-1 PF00472.20 AMD22880.1 - 1.1e-18 67.3 9.0 1.9e-18 66.5 9.0 1.3 1 1 0 1 1 1 1 RF-1 domain DUF1640 PF07798.11 AMD22881.1 - 3.4e-22 79.3 0.3 5.1e-22 78.8 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) PAP1 PF08601.10 AMD22881.1 - 0.028 14.2 0.3 0.034 13.9 0.3 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 ECH_1 PF00378.20 AMD22882.1 - 3.7e-24 85.4 0.0 4.2e-24 85.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 AMD22882.1 - 2.7e-13 50.2 0.0 1.6e-12 47.6 0.0 1.9 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Init_tRNA_PT PF04179.12 AMD22882.1 - 0.029 14.7 0.0 0.079 13.3 0.0 1.7 1 0 0 1 1 1 0 Rit1 DUSP-like domain Methyltransf_16 PF10294.9 AMD22883.1 - 2.3e-10 40.5 0.2 5.7e-09 35.9 0.2 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 AMD22883.1 - 0.00038 20.3 0.0 0.00053 19.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain WH1 PF00568.23 AMD22884.1 - 1e-28 99.5 0.0 1.5e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 WH1 domain CAP_N PF01213.19 AMD22884.1 - 8.2e-06 25.5 8.8 8.2e-06 25.5 8.8 6.2 2 1 3 6 6 6 2 Adenylate cyclase associated (CAP) N terminal WH2 PF02205.20 AMD22884.1 - 0.00012 21.8 0.4 0.00028 20.6 0.4 1.6 1 0 0 1 1 1 1 WH2 motif GCIP PF13324.6 AMD22885.1 - 1.1e-31 110.4 2.0 1.5e-31 110.0 2.0 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting APG6 PF04111.12 AMD22885.1 - 0.016 15.2 0.4 0.26 11.2 0.0 2.2 2 0 0 2 2 2 0 Apg6 BARA domain Syntaxin-6_N PF09177.11 AMD22885.1 - 1.7 9.2 5.5 9.4 6.9 0.6 3.3 2 2 1 3 3 3 0 Syntaxin 6, N-terminal Ribosomal_S30 PF04758.14 AMD22886.1 - 1.1e-29 102.3 6.0 1.3e-29 102.2 6.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Aminotran_5 PF00266.19 AMD22887.1 - 7.5e-38 130.4 0.0 9.2e-38 130.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Mei5 PF10376.9 AMD22887.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Double-strand recombination repair protein Hus1 PF04005.12 AMD22888.1 - 1.1e-27 96.9 1.6 4e-26 91.8 1.6 2.1 1 1 0 1 1 1 1 Hus1-like protein GTP_EFTU PF00009.27 AMD22889.1 - 1.9e-46 158.1 0.0 4e-46 157.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 AMD22889.1 - 6e-39 132.5 5.2 1.4e-38 131.3 5.2 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 AMD22889.1 - 5.7e-18 64.7 0.0 1.1e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AMD22889.1 - 1.6e-05 25.2 0.9 3.9e-05 24.0 0.9 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AMD22889.1 - 2.5e-05 24.4 0.0 6.9e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 AMD22889.1 - 0.00063 19.6 0.1 0.0034 17.2 0.0 2.1 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain Ras PF00071.22 AMD22889.1 - 0.0032 17.1 0.0 0.0068 16.0 0.0 1.5 1 0 0 1 1 1 1 Ras family DUF1931 PF09123.11 AMD22889.1 - 0.012 15.7 0.1 0.16 12.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1931) SRPRB PF09439.10 AMD22889.1 - 0.016 14.7 0.0 0.04 13.3 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 AMD22889.1 - 0.11 12.7 0.0 1.4 9.1 0.0 2.5 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ArgoMid PF16487.5 AMD22889.1 - 0.15 12.3 0.1 5.2 7.4 0.0 2.8 3 0 0 3 3 3 0 Mid domain of argonaute 3Beta_HSD PF01073.19 AMD22890.1 - 0.00012 21.2 0.0 0.00023 20.2 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 AMD22890.1 - 0.00088 18.8 0.0 0.0022 17.5 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 AMD22890.1 - 0.0058 15.8 0.0 0.13 11.4 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 AMD22890.1 - 0.009 15.9 0.0 0.089 12.7 0.0 2.2 1 1 0 1 1 1 1 NAD(P)H-binding IF-2B PF01008.17 AMD22891.1 - 6.1e-78 261.9 0.4 9.7e-78 261.2 0.4 1.3 1 1 0 1 1 1 1 Initiation factor 2 subunit family TPR_2 PF07719.17 AMD22892.1 - 0.00037 20.4 3.1 0.0074 16.3 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 AMD22892.1 - 0.00053 19.7 1.9 0.0029 17.3 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 AMD22892.1 - 0.0072 17.1 2.3 0.044 14.6 0.3 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 AMD22892.1 - 0.023 15.2 0.8 0.023 15.2 0.8 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 AMD22892.1 - 0.035 14.3 1.6 0.062 13.5 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 AMD22892.1 - 0.062 13.5 1.9 0.73 10.0 0.2 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AMD22892.1 - 0.76 9.9 7.4 0.48 10.5 0.6 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Ras PF00071.22 AMD22893.1 - 1.2e-50 171.2 0.0 1.5e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22893.1 - 1e-30 106.4 0.1 2.7e-30 105.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD22893.1 - 2.1e-11 43.6 0.0 2.9e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AMD22893.1 - 0.00079 19.5 0.0 0.0016 18.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 AMD22893.1 - 0.00099 19.5 0.1 0.0065 16.8 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 AMD22893.1 - 0.0015 17.9 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AMD22893.1 - 0.017 14.6 0.0 0.029 13.8 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 AMD22893.1 - 0.017 14.3 2.1 1.8 7.7 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit Pox_A32 PF04665.12 AMD22893.1 - 0.019 14.5 0.1 0.034 13.6 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein GTP_EFTU PF00009.27 AMD22893.1 - 0.026 14.1 0.5 0.12 11.9 0.5 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain ATPase PF06745.13 AMD22893.1 - 0.026 13.9 0.2 0.039 13.3 0.2 1.2 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 AMD22893.1 - 0.026 14.4 0.1 8.5 6.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 AMD22893.1 - 0.032 13.8 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AMD22893.1 - 0.054 13.2 0.1 0.09 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AMD22893.1 - 0.099 12.8 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AMD22893.1 - 0.11 12.5 0.1 0.27 11.2 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 AMD22893.1 - 0.14 12.6 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 AMD22893.1 - 0.14 11.4 0.3 0.24 10.6 0.0 1.6 2 0 0 2 2 2 0 Septin ADIP PF11559.8 AMD22894.1 - 7.6e-05 22.8 1.6 9.2e-05 22.6 0.1 1.9 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding AATF-Che1 PF13339.6 AMD22894.1 - 0.096 13.4 0.8 0.19 12.4 0.0 1.8 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor ATP_sub_h PF10775.9 AMD22895.1 - 3e-24 84.8 0.9 4.2e-24 84.3 0.9 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h zf-U1 PF06220.12 AMD22896.1 - 7.5e-18 64.0 5.7 7.5e-18 64.0 5.7 2.2 2 0 0 2 2 2 1 U1 zinc finger Bim_N PF06773.11 AMD22896.1 - 0.017 14.8 0.2 0.044 13.5 0.0 1.8 2 0 0 2 2 2 0 Bim protein N-terminus Cylicin_N PF15241.6 AMD22896.1 - 0.018 15.2 0.4 0.035 14.2 0.4 1.5 1 0 0 1 1 1 0 Cylicin N-terminus CaKB PF03185.15 AMD22896.1 - 0.27 10.9 0.4 0.37 10.4 0.4 1.3 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit ALMS_repeat PF18727.1 AMD22896.1 - 0.28 11.1 1.5 0.51 10.3 0.2 2.1 3 0 0 3 3 3 0 Alstrom syndrome repeat GTP_EFTU PF00009.27 AMD22897.1 - 8.6e-59 198.3 0.2 1.1e-58 197.9 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AMD22897.1 - 1.3e-26 93.1 0.0 2.6e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AMD22897.1 - 1.6e-20 73.3 1.5 3.8e-20 72.0 1.5 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AMD22897.1 - 2.1e-05 24.5 0.1 5.2e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD22897.1 - 0.012 15.5 0.1 0.031 14.2 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 AMD22897.1 - 0.036 13.8 0.3 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Peptidase_U32_C PF16325.5 AMD22897.1 - 0.053 13.8 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Peptidase family U32 C-terminal domain cobW PF02492.19 AMD22897.1 - 0.066 12.8 1.4 0.072 12.7 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain G_glu_transpept PF01019.21 AMD22898.1 - 9.1e-149 496.5 0.0 1.1e-148 496.2 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF1708 PF08101.11 AMD22899.1 - 3.7e-123 411.9 4.2 9.3e-122 407.3 4.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) Cellulase PF00150.18 AMD22901.1 - 1.9e-11 43.9 0.1 1.9e-10 40.6 0.0 2.3 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) SNF2_N PF00176.23 AMD22902.1 - 1.1e-56 192.1 0.2 3.5e-56 190.4 0.1 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AMD22902.1 - 2.4e-18 66.5 3.0 7.5e-18 64.9 0.1 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 AMD22902.1 - 5.8e-06 26.2 1.0 1.4e-05 25.0 1.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AMD22902.1 - 9.9e-06 25.4 2.0 2.1e-05 24.4 2.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AMD22902.1 - 5.8e-05 23.3 2.6 0.00014 22.1 2.6 1.7 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 AMD22902.1 - 0.00011 22.3 0.0 0.00011 22.3 0.0 3.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 AMD22902.1 - 0.00017 21.4 0.9 0.00017 21.4 0.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD22902.1 - 0.00033 20.5 2.3 0.00073 19.3 2.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD22902.1 - 0.00033 20.4 2.1 0.00082 19.2 2.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AMD22902.1 - 0.0017 18.2 1.9 0.0017 18.2 1.9 2.4 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 sCache_2 PF17200.4 AMD22902.1 - 0.07 13.0 0.4 0.4 10.5 0.0 2.5 2 0 0 2 2 2 0 Single Cache domain 2 zf-C3HC4_4 PF15227.6 AMD22902.1 - 0.23 11.6 2.6 0.68 10.1 2.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Cornichon PF03311.14 AMD22904.1 - 8.7e-48 161.7 10.8 1e-47 161.5 10.8 1.0 1 0 0 1 1 1 1 Cornichon protein RRM_1 PF00076.22 AMD22906.1 - 1.1e-40 137.2 0.0 9.4e-18 63.8 0.0 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AMD22906.1 - 6.2e-08 32.4 0.0 3.6e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_3 PF08777.11 AMD22906.1 - 1.1e-06 28.6 0.0 2e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 RNA binding motif RRM_5 PF13893.6 AMD22906.1 - 9e-05 22.1 0.0 0.29 10.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AMD22906.1 - 0.024 14.8 0.0 0.17 12.0 0.0 2.4 3 0 0 3 3 3 0 RNA recognition motif Nup35_RRM_2 PF14605.6 AMD22906.1 - 0.072 13.1 0.0 0.27 11.2 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 AMD22906.1 - 0.08 13.2 0.1 5.3 7.2 0.1 3.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter EMP70 PF02990.16 AMD22907.1 - 3.5e-191 636.4 11.9 4.9e-191 635.9 11.9 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Tmpp129 PF10272.9 AMD22907.1 - 0.0035 16.7 1.2 0.0035 16.7 1.2 1.8 1 1 1 2 2 2 1 Putative transmembrane protein precursor PatG_C PF18065.1 AMD22907.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 PatG C-terminal TRAPPC-Trs85 PF12739.7 AMD22908.1 - 7.5e-87 291.9 0.0 1.9e-86 290.6 0.0 1.6 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Rax2 PF12768.7 AMD22909.1 - 1.5e-40 139.0 0.8 1.9e-37 128.8 0.0 4.1 4 0 0 4 4 4 2 Cortical protein marker for cell polarity Kelch_4 PF13418.6 AMD22909.1 - 0.019 14.9 3.4 0.44 10.6 0.2 3.6 3 0 0 3 3 3 0 Galactose oxidase, central domain GCR1_C PF12550.8 AMD22910.1 - 5.9e-10 39.3 0.1 1.2e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DivIVA PF05103.13 AMD22910.1 - 0.039 14.0 0.5 0.19 11.8 0.1 2.4 2 0 0 2 2 2 0 DivIVA protein BLOC1_2 PF10046.9 AMD22910.1 - 0.23 11.8 2.6 1.6 9.1 1.1 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FGGY_C PF02782.16 AMD22911.1 - 2.3e-36 125.4 0.0 4.5e-36 124.4 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 AMD22911.1 - 3.8e-22 79.0 0.0 1.6e-21 77.0 0.0 2.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.21 AMD22911.1 - 0.0039 17.1 0.0 0.0066 16.4 0.0 1.3 1 0 0 1 1 1 1 Hexokinase DEDD_Tnp_IS110 PF01548.17 AMD22911.1 - 0.063 13.2 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 Transposase Actin PF00022.19 AMD22912.1 - 6.5e-50 169.9 0.0 7.7e-49 166.4 0.0 1.9 1 1 0 1 1 1 1 Actin SMC_N PF02463.19 AMD22913.1 - 1e-62 211.5 62.9 4.4e-62 209.4 62.9 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AMD22913.1 - 2.6e-25 89.0 0.0 8.3e-25 87.4 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AMD22913.1 - 5.8e-13 49.3 8.6 4.4e-07 30.0 0.0 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AMD22913.1 - 6.6e-13 49.6 12.8 6.6e-13 49.6 12.8 7.9 2 2 3 5 5 1 1 AAA domain AAA_15 PF13175.6 AMD22913.1 - 7e-06 26.0 42.0 7e-06 26.0 42.0 4.8 2 2 2 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 AMD22913.1 - 1.6e-05 24.5 0.0 3.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain IFT57 PF10498.9 AMD22913.1 - 0.00047 19.2 19.4 0.00047 19.2 19.4 6.7 2 2 5 7 7 7 1 Intra-flagellar transport protein 57 GAS PF13851.6 AMD22913.1 - 0.0021 17.4 18.8 0.0021 17.4 18.8 8.4 3 2 5 8 8 8 2 Growth-arrest specific micro-tubule binding OmpH PF03938.14 AMD22913.1 - 0.005 17.2 14.9 0.005 17.2 14.9 9.5 2 2 7 9 9 8 1 Outer membrane protein (OmpH-like) ABC_tran PF00005.27 AMD22913.1 - 0.13 12.8 0.0 0.13 12.8 0.0 7.2 3 2 0 3 3 1 0 ABC transporter TFA2_Winged_2 PF18121.1 AMD22913.1 - 2.3 8.0 7.8 1.9 8.3 0.4 3.8 3 0 0 3 3 3 0 TFA2 Winged helix domain 2 AAA_13 PF13166.6 AMD22913.1 - 7 5.2 111.1 0.054 12.1 33.2 5.0 2 2 5 7 7 7 0 AAA domain Gaa1 PF04114.14 AMD22915.1 - 6.2e-123 411.4 15.3 1e-122 410.8 15.3 1.3 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component AAA PF00004.29 AMD22916.1 - 2.9e-13 50.4 0.2 2.7e-12 47.3 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AMD22916.1 - 5.9e-06 26.3 0.1 0.00038 20.4 0.0 2.9 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 AMD22916.1 - 8.7e-06 26.2 0.0 2.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_assoc_2 PF16193.5 AMD22916.1 - 0.00011 22.5 0.1 0.00038 20.7 0.0 2.0 2 0 0 2 2 1 1 AAA C-terminal domain AAA_14 PF13173.6 AMD22916.1 - 0.0002 21.4 0.0 0.00054 20.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AMD22916.1 - 0.00023 21.4 0.1 0.0041 17.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 AMD22916.1 - 0.00075 19.3 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 AMD22916.1 - 0.0034 17.7 0.0 0.01 16.2 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 AMD22916.1 - 0.0086 16.2 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AMD22916.1 - 0.017 15.7 0.8 0.077 13.5 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 AMD22916.1 - 0.021 14.6 1.1 0.058 13.2 0.0 2.2 3 0 0 3 3 3 0 AAA domain DNA_pol3_delta PF06144.13 AMD22916.1 - 0.021 14.6 0.6 0.059 13.1 0.6 1.9 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_23 PF13476.6 AMD22916.1 - 0.037 14.5 6.1 0.13 12.8 0.0 3.0 3 1 0 3 3 3 0 AAA domain dNK PF01712.19 AMD22916.1 - 0.07 13.0 1.5 11 5.8 0.0 2.8 3 0 0 3 3 3 0 Deoxynucleoside kinase RsgA_GTPase PF03193.16 AMD22916.1 - 0.09 12.7 0.0 0.42 10.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_5 PF07728.14 AMD22916.1 - 0.13 12.3 0.1 0.66 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 AMD22916.1 - 0.18 11.5 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain CRAL_TRIO PF00650.20 AMD22917.1 - 6.4e-35 120.2 0.0 8.7e-35 119.8 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AMD22917.1 - 1.2e-06 28.5 0.0 2.6e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AMD22917.1 - 0.0076 16.4 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SCAN PF02023.17 AMD22917.1 - 0.13 12.1 0.2 0.41 10.5 0.0 1.9 3 0 0 3 3 3 0 SCAN domain RasGAP PF00616.19 AMD22918.1 - 1.5e-40 139.2 4.7 2e-39 135.5 2.6 2.7 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 AMD22918.1 - 0.00034 20.9 0.0 0.00098 19.4 0.0 1.8 1 0 0 1 1 1 1 C2 domain UPF1_Zn_bind PF09416.10 AMD22919.1 - 8.4e-62 207.6 10.4 8.4e-62 207.6 10.4 1.8 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 AMD22919.1 - 3.3e-58 196.6 0.0 1.2e-57 194.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 AMD22919.1 - 2.6e-50 171.6 2.0 1.7e-25 90.3 0.2 2.7 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 AMD22919.1 - 3.4e-25 88.1 0.0 8.2e-25 86.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 AMD22919.1 - 5e-16 59.0 0.0 1.4e-15 57.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AMD22919.1 - 5.2e-13 49.6 0.0 1.3e-12 48.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 AMD22919.1 - 3.1e-05 23.7 0.2 0.024 14.2 0.0 3.0 2 1 0 3 3 3 2 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 AMD22919.1 - 4e-05 23.5 0.0 0.38 10.5 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 AMD22919.1 - 5.5e-05 23.2 0.0 0.00015 21.8 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 AMD22919.1 - 0.00032 20.0 2.6 0.034 13.4 0.0 3.7 3 1 1 4 4 4 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 AMD22919.1 - 0.0016 17.5 0.0 0.0033 16.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein PIF1 PF05970.14 AMD22919.1 - 0.0016 17.6 0.0 1.2 8.2 0.0 2.3 2 0 0 2 2 2 2 PIF1-like helicase PhoH PF02562.16 AMD22919.1 - 0.0021 17.6 0.0 0.0063 16.0 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein Helicase_RecD PF05127.14 AMD22919.1 - 0.0029 17.5 0.0 0.0089 15.9 0.0 1.9 1 0 0 1 1 1 1 Helicase DEAD PF00270.29 AMD22919.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase Mg_chelatase PF01078.21 AMD22919.1 - 0.047 13.1 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 AMD22919.1 - 0.11 12.8 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 AMD22919.1 - 0.15 12.5 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Flavi_DEAD PF07652.14 AMD22919.1 - 0.17 11.9 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Flavivirus DEAD domain MBR1 PF17058.5 AMD22920.1 - 9.4e-21 75.1 5.5 9.4e-21 75.1 5.5 2.6 2 1 0 2 2 2 1 Mitochondrial biogenesis regulation protein 1 HalOD2 PF18547.1 AMD22920.1 - 0.2 11.6 1.0 0.83 9.6 0.2 2.2 2 0 0 2 2 2 0 Halobacterial output domain 2 DUF572 PF04502.13 AMD22921.1 - 5.7e-44 151.1 14.2 9.9e-44 150.3 14.2 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF572) Mu-like_Com PF10122.9 AMD22921.1 - 0.13 11.7 0.7 0.34 10.4 0.1 2.0 2 0 0 2 2 2 0 Mu-like prophage protein Com Mut7-C PF01927.16 AMD22921.1 - 0.14 12.3 1.9 0.19 11.8 0.1 2.0 2 0 0 2 2 2 0 Mut7-C RNAse domain DUF29 PF01724.16 AMD22921.1 - 0.46 10.7 7.7 0.3 11.3 5.8 1.6 2 0 0 2 2 2 0 Domain of unknown function DUF29 Zn_Tnp_IS1 PF03811.13 AMD22921.1 - 0.5 10.1 2.7 0.49 10.2 0.2 2.1 2 0 0 2 2 2 0 InsA N-terminal domain zf_UBZ PF18439.1 AMD22921.1 - 0.61 9.7 2.8 7.9 6.2 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF1455 PF07306.11 AMD22922.1 - 0.0044 17.0 1.1 0.36 10.8 0.5 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1455) PIR PF00399.19 AMD22923.1 - 2.7e-07 30.0 5.3 9.5e-07 28.2 5.3 2.0 1 0 0 1 1 1 1 Yeast PIR protein repeat RNA_pol_Rpb2_6 PF00562.28 AMD22924.1 - 1.4e-114 383.2 0.0 2.6e-114 382.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AMD22924.1 - 9e-42 142.9 0.1 1.3e-41 142.4 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AMD22924.1 - 1.1e-31 110.0 0.0 2.1e-31 109.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 AMD22924.1 - 5.4e-28 97.0 0.0 1.8e-27 95.3 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 AMD22924.1 - 2.9e-24 84.8 0.0 5.9e-24 83.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 AMD22924.1 - 3e-16 59.6 0.0 9.3e-15 54.8 0.0 2.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 Thg1 PF04446.12 AMD22926.1 - 1.6e-49 167.1 1.8 2.7e-49 166.4 0.9 1.7 2 0 0 2 2 2 1 tRNAHis guanylyltransferase Thg1C PF14413.6 AMD22926.1 - 3.9e-37 127.1 0.7 7.3e-37 126.2 0.4 1.6 2 0 0 2 2 2 1 Thg1 C terminal domain UPF0121 PF03661.13 AMD22927.1 - 3.8e-06 26.5 10.4 0.00035 20.0 7.7 2.8 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0121) Ribosomal_S25 PF03297.15 AMD22928.1 - 5.6e-39 132.4 6.5 6.3e-39 132.3 6.5 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 AMD22928.1 - 0.00047 19.9 0.1 0.00071 19.3 0.1 1.3 1 0 0 1 1 1 1 Ftsk gamma domain EAP30 PF04157.16 AMD22928.1 - 0.023 14.0 0.1 0.03 13.6 0.1 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family HTH_CodY PF08222.11 AMD22928.1 - 0.046 13.3 0.2 0.073 12.6 0.2 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain MerR PF00376.23 AMD22928.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 MerR family regulatory protein Ran_BP1 PF00638.18 AMD22929.1 - 9.2e-31 106.6 0.1 2.3e-30 105.3 0.1 1.7 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.11 AMD22929.1 - 4.1e-11 43.4 3.1 4.1e-11 43.4 3.1 3.2 3 1 0 3 3 3 1 NUP50 (Nucleoporin 50 kDa) rve_3 PF13683.6 AMD22929.1 - 0.097 12.5 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain MA3 PF02847.17 AMD22930.1 - 5.5e-26 90.8 0.6 3.2e-25 88.3 0.1 2.6 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 AMD22930.1 - 5.7e-20 71.9 5.7 1.3e-19 70.7 5.7 1.7 1 0 0 1 1 1 1 MIF4G domain AAA PF00004.29 AMD22931.1 - 3.2e-37 127.9 0.0 5.6e-37 127.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AMD22931.1 - 4.8e-10 39.1 0.1 1.1e-09 37.9 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 AMD22931.1 - 1.1e-06 28.7 0.0 3.3e-06 27.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AMD22931.1 - 2.8e-06 27.8 1.4 0.0008 19.8 0.0 3.2 2 2 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 AMD22931.1 - 4e-06 26.7 0.0 8e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 AMD22931.1 - 9.4e-06 25.7 0.1 8.1e-05 22.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 AMD22931.1 - 2.8e-05 24.3 0.0 5.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AMD22931.1 - 3.7e-05 24.0 0.2 0.012 15.9 0.0 3.1 1 1 2 3 3 3 1 AAA domain AAA_18 PF13238.6 AMD22931.1 - 4.3e-05 24.1 0.0 0.0003 21.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 AMD22931.1 - 5.9e-05 22.5 0.0 0.41 10.0 0.0 2.5 1 1 0 2 2 2 2 Bacterial TniB protein Sigma54_activ_2 PF14532.6 AMD22931.1 - 9e-05 22.6 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 AMD22931.1 - 0.00069 19.4 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 AMD22931.1 - 0.00099 18.5 0.2 0.0026 17.2 0.1 1.6 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 AMD22931.1 - 0.0012 18.1 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 AMD22931.1 - 0.0013 19.1 0.0 0.0038 17.6 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 AMD22931.1 - 0.0021 17.6 0.0 0.0089 15.6 0.0 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 AMD22931.1 - 0.0021 18.2 0.0 0.0052 17.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain Rad17 PF03215.15 AMD22931.1 - 0.0054 16.7 0.1 0.015 15.2 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_25 PF13481.6 AMD22931.1 - 0.0058 16.2 0.0 0.045 13.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AMD22931.1 - 0.007 16.1 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AMD22931.1 - 0.0076 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin TIP49 PF06068.13 AMD22931.1 - 0.011 14.9 0.1 0.038 13.2 0.0 1.8 1 1 1 2 2 2 0 TIP49 P-loop domain Hydin_ADK PF17213.3 AMD22931.1 - 0.012 16.0 0.1 0.35 11.1 0.0 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_17 PF13207.6 AMD22931.1 - 0.013 15.9 0.0 0.03 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AMD22931.1 - 0.016 14.9 0.0 0.059 13.1 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.6 AMD22931.1 - 0.024 14.9 0.0 0.054 13.7 0.0 1.6 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 AMD22931.1 - 0.028 14.9 0.0 0.075 13.6 0.0 1.7 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 AMD22931.1 - 0.033 14.1 0.2 0.098 12.6 0.0 1.9 2 0 0 2 2 1 0 NACHT domain CcdB PF01845.17 AMD22931.1 - 0.04 14.1 0.0 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 CcdB protein AAA_3 PF07726.11 AMD22931.1 - 0.048 13.5 0.0 0.095 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 AMD22931.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 AMD22931.1 - 0.072 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FCH PF00611.23 AMD22931.1 - 0.072 13.4 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Bac_DnaA PF00308.18 AMD22931.1 - 0.09 12.6 0.0 0.18 11.6 0.0 1.4 1 1 0 1 1 1 0 Bacterial dnaA protein Viral_helicase1 PF01443.18 AMD22931.1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 AMD22931.1 - 0.11 12.4 0.2 0.8 9.6 0.0 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea tRNA_lig_kinase PF08303.11 AMD22931.1 - 0.15 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 tRNA ligase kinase domain CoA_transf_3 PF02515.17 AMD22931.1 - 0.22 10.6 0.0 0.51 9.4 0.0 1.5 1 0 0 1 1 1 0 CoA-transferase family III Evr1_Alr PF04777.13 AMD22932.1 - 2.2e-29 101.8 3.1 2.2e-29 101.8 3.1 1.4 2 0 0 2 2 2 1 Erv1 / Alr family SNAD4 PF18750.1 AMD22932.1 - 0.053 13.7 0.1 0.098 12.8 0.1 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 C1_2 PF03107.16 AMD22932.1 - 0.18 12.1 2.3 12 6.3 0.1 3.0 3 0 0 3 3 3 0 C1 domain WH2 PF02205.20 AMD22933.1 - 1.2e-13 50.4 1.3 2.2e-10 40.0 0.3 3.0 3 0 0 3 3 3 2 WH2 motif CAP_N PF01213.19 AMD22933.1 - 0.0068 15.9 4.4 0.0068 15.9 4.4 7.8 3 2 3 6 6 6 1 Adenylate cyclase associated (CAP) N terminal OTU PF02338.19 AMD22934.1 - 1.6e-26 93.3 1.5 2.8e-26 92.5 0.0 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 AMD22934.1 - 4.9e-05 22.9 3.6 0.00027 20.5 0.1 2.8 3 0 0 3 3 3 1 Peptidase C65 Otubain Cep57_MT_bd PF06657.13 AMD22934.1 - 0.0065 16.9 6.3 0.022 15.2 6.3 2.0 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 DUF4407 PF14362.6 AMD22934.1 - 3.2 7.0 8.8 4.3 6.6 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_GP20 PF06810.11 AMD22934.1 - 6.2 6.6 13.5 0.92 9.3 1.8 2.6 3 0 0 3 3 3 0 Phage minor structural protein GP20 YchF-GTPase_C PF06071.13 AMD22935.1 - 8.3e-33 112.4 0.0 1.8e-32 111.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 AMD22935.1 - 7.1e-15 55.1 0.0 1.3e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AMD22935.1 - 0.0002 20.9 0.0 0.00046 19.7 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Ribosomal_S10 PF00338.22 AMD22936.1 - 1.3e-23 83.1 0.5 1.9e-23 82.5 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Retrotrans_gag PF03732.17 AMD22936.1 - 0.06 13.6 0.0 0.091 13.0 0.0 1.5 1 1 0 1 1 1 0 Retrotransposon gag protein GBR2_CC PF18455.1 AMD22936.1 - 0.064 13.4 0.4 0.17 12.0 0.4 1.7 1 0 0 1 1 1 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain Lung_7-TM_R PF06814.13 AMD22937.1 - 4.9e-76 255.8 23.4 6.2e-76 255.5 23.4 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor DctQ PF04290.12 AMD22937.1 - 0.028 14.4 1.5 0.028 14.4 1.5 3.8 2 1 2 4 4 4 0 Tripartite ATP-independent periplasmic transporters, DctQ component Pho86 PF11124.8 AMD22937.1 - 3.9 6.9 9.3 0.44 10.0 0.4 2.5 1 1 1 2 2 2 0 Inorganic phosphate transporter Pho86 SUR7 PF06687.12 AMD22937.1 - 4 7.0 13.8 38 3.8 13.8 2.6 1 1 0 1 1 1 0 SUR7/PalI family NifU PF01106.17 AMD22938.1 - 5.7e-25 87.3 0.1 1e-24 86.5 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 AMD22938.1 - 2e-23 82.2 0.5 1.4e-22 79.5 0.1 2.4 3 0 0 3 3 3 1 Scaffold protein Nfu/NifU N terminal YojJ PF10372.9 AMD22938.1 - 0.085 13.0 0.6 0.085 13.0 0.6 1.6 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Pterin_4a PF01329.19 AMD22939.1 - 2.2e-26 91.9 0.1 2.6e-26 91.6 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Adap_comp_sub PF00928.21 AMD22940.1 - 1.3e-59 201.7 0.2 1.9e-59 201.2 0.2 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Opi1 PF08618.10 AMD22941.1 - 7.6e-31 107.8 5.2 1.7e-22 80.3 2.4 2.1 1 1 1 2 2 2 2 Transcription factor Opi1 Seadorna_Vp10 PF07322.11 AMD22941.1 - 0.019 14.4 0.2 0.63 9.4 0.0 2.1 1 1 1 2 2 2 0 Seadornavirus Vp10 Ribosomal_S13 PF00416.22 AMD22941.1 - 0.48 10.8 5.2 0.18 12.2 1.7 2.1 2 0 0 2 2 2 0 Ribosomal protein S13/S18 FliJ PF02050.16 AMD22941.1 - 0.49 10.6 12.7 0.084 13.1 7.7 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein Snf7 PF03357.21 AMD22942.1 - 7.2e-30 103.8 20.7 7.2e-30 103.8 20.7 1.6 1 1 1 2 2 2 1 Snf7 PAS_7 PF12860.7 AMD22942.1 - 0.0042 17.2 2.7 0.048 13.8 0.4 2.8 1 1 2 3 3 3 1 PAS fold CRR7 PF12095.8 AMD22942.1 - 0.026 15.0 0.5 0.026 15.0 0.5 3.2 2 1 1 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 Peptidase_S46 PF10459.9 AMD22942.1 - 1.9 7.0 15.1 7 5.2 15.2 1.6 1 1 0 1 1 1 0 Peptidase S46 DUF4404 PF14357.6 AMD22942.1 - 9.2 7.0 20.2 3.5 8.3 2.9 4.1 3 2 1 4 4 4 0 Domain of unknown function (DUF4404) AAA PF00004.29 AMD22943.1 - 5.2e-41 140.2 0.0 1.1e-40 139.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 AMD22943.1 - 4.2e-19 68.2 0.2 8.4e-19 67.3 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 AMD22943.1 - 6e-07 29.2 0.0 1.5e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AMD22943.1 - 3.3e-06 27.6 0.1 0.0039 17.6 0.0 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 AMD22943.1 - 2.6e-05 24.4 0.1 0.00015 21.9 0.0 2.3 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AMD22943.1 - 0.00014 21.9 2.1 0.00028 20.9 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AMD22943.1 - 0.00027 20.7 0.0 0.00066 19.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AMD22943.1 - 0.0017 18.7 1.1 0.12 12.7 0.0 2.7 2 1 1 3 3 3 1 AAA domain PhoH PF02562.16 AMD22943.1 - 0.0057 16.1 0.1 0.04 13.4 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 AMD22943.1 - 0.009 15.2 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 AMD22943.1 - 0.011 15.1 0.2 0.03 13.7 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 AMD22943.1 - 0.022 14.9 0.0 0.08 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain TolA_bind_tri PF16331.5 AMD22943.1 - 0.024 14.7 2.2 0.087 12.9 0.7 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation AAA_11 PF13086.6 AMD22943.1 - 0.026 14.3 0.2 0.096 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 AMD22943.1 - 0.037 13.8 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.6 AMD22943.1 - 0.04 14.3 0.1 0.11 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AMD22943.1 - 0.051 13.1 0.0 0.11 12.0 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 AMD22943.1 - 0.093 13.1 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 AMD22943.1 - 0.15 11.8 0.6 0.42 10.3 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AMD22943.1 - 0.17 11.6 0.9 0.49 10.1 0.1 2.4 3 1 0 3 3 2 0 AAA domain WD40 PF00400.32 AMD22944.1 - 7.9e-39 131.0 11.6 1.9e-09 38.0 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22944.1 - 2.1e-17 63.2 0.0 0.00076 19.7 0.0 5.6 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AMD22944.1 - 0.0013 17.8 0.1 0.068 12.1 0.0 2.4 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 AMD22944.1 - 0.041 13.2 0.0 10 5.4 0.0 2.4 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 AMD22944.1 - 0.059 12.0 0.6 12 4.4 0.1 3.3 2 1 1 3 3 3 0 Nucleoporin Nup120/160 A_deaminase PF00962.22 AMD22945.1 - 1.6e-126 422.1 0.0 2.2e-126 421.7 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase DHHC PF01529.20 AMD22946.1 - 8.3e-28 97.2 5.0 8.3e-28 97.2 5.0 2.3 2 0 0 2 2 2 2 DHHC palmitoyltransferase MAT1 PF06391.13 AMD22947.1 - 2e-62 210.7 28.9 2.6e-62 210.3 28.9 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 AMD22947.1 - 9.4e-29 99.1 7.7 1.8e-28 98.2 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AMD22947.1 - 0.00024 20.9 4.7 0.00053 19.8 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AMD22947.1 - 0.0003 21.1 6.1 0.00053 20.3 6.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 AMD22947.1 - 0.00079 19.2 5.2 0.0015 18.4 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AMD22947.1 - 0.0084 16.0 5.5 0.032 14.1 5.6 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AMD22947.1 - 0.031 14.3 6.3 0.062 13.3 6.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 AMD22947.1 - 0.047 13.3 1.2 0.089 12.4 1.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 AMD22947.1 - 0.092 12.7 9.3 1.4 9.0 9.4 2.3 1 1 1 2 2 2 0 zinc-RING finger domain DUF4504 PF14953.6 AMD22947.1 - 0.12 11.7 3.2 0.2 11.0 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4504) 3HCDH_N PF02737.18 AMD22947.1 - 0.14 12.0 4.3 0.24 11.2 4.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FliS PF02561.14 AMD22947.1 - 0.43 10.9 9.9 0.09 13.0 1.7 2.3 1 1 1 2 2 2 0 Flagellar protein FliS zf-RING_4 PF14570.6 AMD22947.1 - 0.99 9.2 9.6 9.6 6.1 9.6 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 AMD22947.1 - 1 9.2 8.7 4.7 7.2 3.0 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF3797 PF12677.7 AMD22947.1 - 2.7 8.0 5.9 1.4 8.8 2.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) CGI-121 PF08617.10 AMD22948.1 - 4.3e-40 137.5 0.5 4.9e-40 137.3 0.5 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Sel1 PF08238.12 AMD22949.1 - 1.2e-35 121.1 19.8 8.8e-08 32.6 0.1 8.0 7 2 0 7 7 7 7 Sel1 repeat TPR_17 PF13431.6 AMD22949.1 - 1.2 9.7 3.9 76 4.0 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3767 PF12597.8 AMD22950.1 - 1.9e-36 123.9 0.1 2.7e-36 123.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) CPP1-like PF11833.8 AMD22950.1 - 0.062 13.0 0.3 0.072 12.7 0.3 1.5 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like YrhK PF14145.6 AMD22950.1 - 0.11 12.4 0.7 0.19 11.6 0.7 1.4 1 0 0 1 1 1 0 YrhK-like protein LigB PF02900.18 AMD22951.1 - 1.9e-26 92.7 0.0 3.6e-25 88.6 0.0 2.0 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase KTSC PF13619.6 AMD22951.1 - 0.063 13.1 0.1 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 KTSC domain GatD_N PF18195.1 AMD22952.1 - 0.06 12.7 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 GatD N-terminal domain Cupin_8 PF13621.6 AMD22952.1 - 2.1 8.0 6.1 1 9.0 1.9 2.2 1 1 1 2 2 2 0 Cupin-like domain Ribosomal_L10 PF00466.20 AMD22953.1 - 8.5e-07 29.0 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Methyltransf_4 PF02390.17 AMD22954.1 - 7e-61 204.7 0.1 9.3e-61 204.3 0.1 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 AMD22954.1 - 0.00099 18.9 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AMD22954.1 - 0.001 19.8 0.0 0.0028 18.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AMD22954.1 - 0.0018 17.8 0.0 0.019 14.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 AMD22954.1 - 0.012 15.0 0.1 0.024 14.0 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DOT1 PF08123.13 AMD22954.1 - 0.022 14.3 0.0 0.051 13.1 0.0 1.6 2 0 0 2 2 2 0 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 AMD22954.1 - 0.14 13.0 0.2 0.51 11.1 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Mito_carr PF00153.27 AMD22955.1 - 2.6e-30 104.2 0.8 3.1e-15 55.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CFIA_Pcf11 PF11526.8 AMD22956.1 - 3e-20 72.5 4.2 3e-20 72.5 4.2 3.0 3 0 0 3 3 3 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 AMD22956.1 - 0.023 15.5 1.7 0.064 14.1 0.0 2.6 3 0 0 3 3 3 0 RNA polymerase II-binding domain. zf-HYPF PF07503.12 AMD22956.1 - 0.15 11.8 0.1 0.4 10.5 0.1 1.6 1 0 0 1 1 1 0 HypF finger LMBR1 PF04791.16 AMD22956.1 - 0.92 8.3 5.9 1.7 7.4 5.9 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Activator_LAG-3 PF11498.8 AMD22956.1 - 2.3 7.1 48.3 4.3 6.2 48.3 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 V_ATPase_I PF01496.19 AMD22956.1 - 2.6 5.9 13.8 0.11 10.4 7.9 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SIR4_SID PF16991.5 AMD22957.1 - 1.3e-13 51.3 0.2 1.3e-13 51.3 0.2 3.6 2 2 1 3 3 3 1 Sir4 SID domain DUF3486 PF11985.8 AMD22957.1 - 0.0059 17.0 4.6 0.32 11.4 3.8 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3486) TolA_bind_tri PF16331.5 AMD22957.1 - 0.014 15.5 14.2 0.27 11.3 1.3 3.8 3 0 0 3 3 3 0 TolA binding protein trimerisation HrpB7 PF09486.10 AMD22957.1 - 0.27 11.6 5.7 1.8 8.9 2.5 2.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) SIR4_SID PF16991.5 AMD22958.1 - 4e-24 85.5 0.7 4e-24 85.5 0.7 3.8 4 1 0 4 4 4 1 Sir4 SID domain Phage_GPO PF05929.11 AMD22958.1 - 0.31 10.6 3.2 0.82 9.2 3.2 1.7 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ADK PF00406.22 AMD22959.1 - 1.1e-60 204.2 0.0 1.2e-60 204.0 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AMD22959.1 - 1.9e-22 80.2 0.1 3.8e-22 79.2 0.0 1.5 1 1 1 2 2 2 1 AAA domain ADK_lid PF05191.14 AMD22959.1 - 2.9e-17 62.4 0.0 6e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 AMD22959.1 - 1e-05 25.7 0.0 3e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AMD22959.1 - 0.0001 22.8 0.0 0.00018 22.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AMD22959.1 - 0.017 14.8 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 AMD22959.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase zf-C2H2 PF00096.26 AMD22960.1 - 2.2e-11 43.6 9.3 4.8e-05 23.6 1.2 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AMD22960.1 - 1.8e-07 31.4 12.7 0.0022 18.7 1.3 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AMD22960.1 - 7e-07 29.4 17.7 1.7e-05 25.0 0.4 3.9 4 0 0 4 4 3 2 Zinc-finger double domain zf-met PF12874.7 AMD22960.1 - 0.00066 20.0 9.6 0.026 14.9 0.3 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 AMD22960.1 - 0.028 14.2 6.6 1.4 8.7 3.5 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type Rad54_N PF08658.10 AMD22960.1 - 0.054 13.7 0.5 0.1 12.8 0.5 1.4 1 0 0 1 1 1 0 Rad54 N terminal DUF2256 PF10013.9 AMD22960.1 - 0.13 12.4 3.8 0.51 10.5 0.7 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_jaz PF12171.8 AMD22960.1 - 0.23 11.8 9.0 0.25 11.7 0.8 2.7 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 AMD22960.1 - 0.3 11.4 5.3 5.2 7.4 0.4 2.4 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 AMD22960.1 - 0.46 10.8 6.2 4.7 7.6 0.6 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 AMD22960.1 - 0.53 10.1 14.1 5.3 6.9 7.8 3.4 2 1 0 2 2 2 0 C2H2-type zinc-finger domain Zn_ribbon_SprT PF17283.2 AMD22960.1 - 0.76 9.7 4.3 1.2 9.1 2.7 2.3 1 1 1 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2_6 PF13912.6 AMD22960.1 - 1.6 8.8 8.3 0.55 10.3 1.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Histone_H2A_C PF16211.5 AMD22962.1 - 3.1e-21 74.8 1.0 5.1e-21 74.1 1.0 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 AMD22962.1 - 4.1e-18 66.0 0.0 5.6e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AMD22962.1 - 3.1e-06 27.4 0.0 5.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 AMD22962.1 - 0.065 13.2 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 LcrG protein Histone PF00125.24 AMD22963.1 - 5.1e-21 75.4 4.5 6.3e-21 75.1 4.5 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AMD22963.1 - 7.4e-06 26.2 0.1 7.4e-06 26.2 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 AMD22963.1 - 0.0018 18.7 0.0 0.0036 17.8 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 AMD22963.1 - 0.011 16.0 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 AMD22963.1 - 0.032 14.3 0.2 0.038 14.0 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein VIT1 PF01988.19 AMD22964.1 - 5.5e-60 202.9 0.4 6.5e-60 202.7 0.4 1.1 1 0 0 1 1 1 1 VIT family T3RM_EcoP15I_C PF18273.1 AMD22964.1 - 0.038 14.3 0.0 0.062 13.6 0.0 1.3 1 0 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain Rsa3 PF14615.6 AMD22965.1 - 7.5e-20 70.2 0.2 1.3e-19 69.5 0.2 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 IMUP PF15761.5 AMD22965.1 - 0.014 16.1 9.0 0.029 15.1 9.0 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 AMD22965.1 - 0.056 13.0 9.7 0.083 12.5 9.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GEMIN8 PF15348.6 AMD22965.1 - 0.14 12.4 3.1 0.17 12.2 3.1 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Utp13 PF08625.11 AMD22966.1 - 6.4e-48 162.3 0.6 1.1e-47 161.6 0.6 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 AMD22966.1 - 2.6e-43 145.2 24.8 3.2e-05 24.6 0.2 11.3 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AMD22966.1 - 2.3e-20 72.7 7.5 6.9e-05 23.1 0.1 7.7 4 3 3 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AMD22966.1 - 1.3e-10 40.6 6.7 0.2 10.2 0.1 6.7 4 1 1 7 7 7 5 Nucleoporin Nup120/160 WD40_like PF17005.5 AMD22966.1 - 6.7e-10 38.8 5.4 1.3e-05 24.7 0.5 4.3 4 1 1 5 5 5 2 WD40-like domain Nucleoporin_N PF08801.11 AMD22966.1 - 0.011 14.5 0.4 0.31 9.7 0.0 3.3 3 1 1 4 4 4 0 Nup133 N terminal like DUF5046 PF16465.5 AMD22966.1 - 0.036 13.5 2.4 13 5.2 0.1 3.9 3 2 1 4 4 4 0 Domain of unknown function (DUF5046) CRF1 PF10380.9 AMD22967.1 - 2.2e-30 105.3 3.0 2.2e-30 105.3 3.0 2.7 2 0 0 2 2 2 1 Transcription factor CRF1 LodA_N PF17990.1 AMD22967.1 - 0.0028 17.6 0.3 0.0073 16.3 0.3 1.7 1 0 0 1 1 1 1 L-Lysine epsilon oxidase N-terminal PRKCSH-like PF12999.7 AMD22968.1 - 4.2e-47 160.2 4.3 7.8e-47 159.3 3.2 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 AMD22968.1 - 1.1e-19 70.7 0.8 1.8e-18 66.7 0.0 3.1 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein MBR1 PF17058.5 AMD22968.1 - 0.0031 17.9 1.0 0.013 15.8 0.2 2.3 2 1 0 2 2 2 1 Mitochondrial biogenesis regulation protein 1 USP8_interact PF08941.10 AMD22968.1 - 0.0097 15.7 0.0 0.039 13.8 0.0 2.0 1 0 0 1 1 1 1 USP8 interacting PRKCSH PF07915.13 AMD22968.1 - 0.011 16.7 0.0 0.035 15.1 0.0 1.9 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein LPP PF04728.13 AMD22968.1 - 0.014 15.7 1.7 0.56 10.6 0.5 3.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ZapB PF06005.12 AMD22968.1 - 0.018 15.5 0.5 0.071 13.6 0.5 2.0 1 0 0 1 1 1 0 Cell division protein ZapB Cep57_CLD_2 PF14197.6 AMD22968.1 - 0.033 14.3 0.9 0.033 14.3 0.9 3.3 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 GLTP PF08718.11 AMD22968.1 - 0.054 13.8 4.8 0.025 14.9 1.9 1.9 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) HALZ PF02183.18 AMD22968.1 - 0.055 13.7 0.9 0.69 10.2 0.3 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper Herpes_UL6 PF01763.16 AMD22968.1 - 0.13 10.8 4.8 0.13 10.8 0.9 2.1 1 1 0 2 2 2 0 Herpesvirus UL6 like NEMO PF11577.8 AMD22968.1 - 0.13 12.3 0.9 0.35 10.9 0.9 1.7 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO DUF4407 PF14362.6 AMD22968.1 - 0.24 10.7 1.0 13 5.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CENP-Q PF13094.6 AMD22968.1 - 1.4 9.1 4.8 4.6 7.4 0.3 2.5 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Prefoldin_2 PF01920.20 AMD22968.1 - 4.5 7.3 8.9 4.7 7.2 0.5 3.0 3 0 0 3 3 3 0 Prefoldin subunit BLOC1_2 PF10046.9 AMD22968.1 - 7 7.0 7.6 1.9 8.8 0.2 3.5 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 F-box-like PF12937.7 AMD22969.1 - 3.1e-07 30.2 0.1 6e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AMD22969.1 - 1.6e-06 27.8 0.0 3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 AMD22969.1 - 0.0006 19.7 0.1 0.0012 18.7 0.1 1.5 1 0 0 1 1 1 1 F-box PRANC PF09372.10 AMD22969.1 - 0.07 13.5 0.1 0.18 12.2 0.1 1.7 1 0 0 1 1 1 0 PRANC domain PBP1_TM PF14812.6 AMD22969.1 - 0.21 12.0 5.0 0.1 13.0 1.4 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cyclin_N PF00134.23 AMD22970.1 - 0.032 14.0 3.4 0.17 11.7 3.4 2.0 1 1 0 1 1 1 0 Cyclin, N-terminal domain Septin PF00735.18 AMD22971.1 - 1.6e-80 270.4 3.8 1.5e-79 267.2 3.8 2.0 1 1 0 1 1 1 1 Septin Dynamin_N PF00350.23 AMD22971.1 - 0.00052 20.1 0.0 0.0016 18.5 0.0 1.8 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 AMD22971.1 - 0.0009 19.3 0.0 0.0023 18.0 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AMD22971.1 - 0.0022 17.9 0.1 0.33 10.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Pox_A32 PF04665.12 AMD22971.1 - 0.0024 17.4 0.3 0.0056 16.2 0.0 1.7 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_24 PF13479.6 AMD22971.1 - 0.0024 17.6 0.0 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AMD22971.1 - 0.0033 17.7 0.0 0.0068 16.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 AMD22971.1 - 0.006 15.7 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein G-alpha PF00503.20 AMD22971.1 - 0.0072 15.5 3.4 0.085 12.0 0.0 2.6 1 1 1 3 3 3 1 G-protein alpha subunit AAA_23 PF13476.6 AMD22971.1 - 0.0092 16.5 0.1 0.019 15.5 0.1 1.6 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 AMD22971.1 - 0.0094 15.7 0.1 0.16 11.7 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 AMD22971.1 - 0.0099 16.4 0.1 0.027 15.0 0.1 1.8 1 1 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.18 AMD22971.1 - 0.012 15.0 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Microtub_bd PF16796.5 AMD22971.1 - 0.012 15.5 0.0 0.033 14.1 0.0 1.7 1 0 0 1 1 1 0 Microtubule binding Roc PF08477.13 AMD22971.1 - 0.014 15.6 0.0 0.066 13.4 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 AMD22971.1 - 0.025 14.2 0.3 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 AMD22971.1 - 0.04 14.1 0.0 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AMD22971.1 - 0.044 13.7 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain GTP_EFTU PF00009.27 AMD22971.1 - 0.076 12.5 1.7 3.1 7.3 0.0 2.5 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 AMD22971.1 - 0.13 12.7 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Rad9_Rad53_bind PF08605.10 AMD22973.1 - 5.7e-39 133.2 0.1 2.1e-38 131.4 0.1 2.1 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.26 AMD22973.1 - 3.9e-11 43.2 0.3 9.3e-11 42.0 0.3 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 AMD22973.1 - 3.9e-05 24.0 0.2 0.0019 18.6 0.1 2.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 AMD22973.1 - 0.064 13.1 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain zf-C2H2 PF00096.26 AMD22974.1 - 5.6e-11 42.3 7.6 8.2e-05 22.9 1.8 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AMD22974.1 - 1.4e-06 28.4 4.8 4.4e-05 23.7 1.6 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AMD22974.1 - 3.1e-06 27.6 10.4 0.01 16.6 0.2 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 AMD22974.1 - 9e-05 22.7 1.2 0.51 10.8 0.0 3.0 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AMD22974.1 - 0.00022 21.1 3.0 0.013 15.5 0.6 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AMD22974.1 - 0.01 16.1 0.5 8.7 6.8 0.0 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 AMD22974.1 - 0.043 14.1 0.6 0.043 14.1 0.6 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-MYST PF17772.1 AMD22974.1 - 0.11 12.1 0.1 1 9.0 0.0 2.5 2 0 0 2 2 2 0 MYST family zinc finger domain Aha1_N PF09229.11 AMD22975.1 - 2.9e-37 127.9 0.0 5.2e-37 127.1 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 AMD22975.1 - 1.2e-10 41.6 0.0 2.1e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Fungal_trans_2 PF11951.8 AMD22976.1 - 4.9e-11 42.1 0.7 1.1e-10 41.0 0.7 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AMD22976.1 - 1.5e-09 37.8 13.3 2.8e-09 36.9 13.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cpn60_TCP1 PF00118.24 AMD22977.1 - 7.6e-154 513.0 15.1 8.6e-154 512.8 15.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ras PF00071.22 AMD22978.1 - 2.6e-51 173.5 0.0 3e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AMD22978.1 - 1.6e-18 67.0 0.0 2.3e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AMD22978.1 - 1.7e-07 30.8 0.0 2.3e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family W2 PF02020.18 AMD22979.1 - 6.6e-15 55.0 0.7 1.9e-14 53.6 0.7 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 AMD22979.1 - 7.9e-12 45.3 0.0 1.9e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 AMD22979.1 - 2.7e-09 36.4 13.2 0.0053 16.4 0.9 4.0 1 1 3 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 AMD22979.1 - 0.0033 17.8 0.0 0.0075 16.6 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 AMD22979.1 - 0.0061 15.5 0.9 0.017 14.0 0.9 1.7 1 1 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 AMD22979.1 - 0.028 14.1 15.5 0.18 11.6 0.7 3.1 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 AMD22979.1 - 0.08 11.1 7.4 0.024 12.8 1.8 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4954) DUF2340 PF10209.9 AMD22980.1 - 3.1e-52 176.1 3.4 3.5e-52 175.9 3.4 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Peptidase_C13 PF01650.18 AMD22980.1 - 0.00026 20.6 0.3 0.00032 20.3 0.3 1.0 1 0 0 1 1 1 1 Peptidase C13 family DUF4252 PF14060.6 AMD22980.1 - 0.029 14.3 0.1 0.034 14.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) DUF676 PF05057.14 AMD22981.1 - 1.3e-41 142.5 0.3 2.4e-41 141.7 0.3 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 AMD22981.1 - 0.00023 21.0 0.1 0.0006 19.6 0.1 1.6 1 0 0 1 1 1 1 PGAP1-like protein SecE PF00584.20 AMD22981.1 - 0.034 14.1 0.4 0.076 13.0 0.4 1.5 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex Palm_thioest PF02089.15 AMD22981.1 - 0.054 13.3 0.0 0.088 12.6 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF5595 PF18077.1 AMD22981.1 - 0.1 12.7 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Sld7_N PF18636.1 AMD22982.1 - 2e-27 96.0 0.0 3.4e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain Sld7_C PF18596.1 AMD22982.1 - 2.7e-19 69.1 0.2 4.5e-19 68.3 0.2 1.4 1 0 0 1 1 1 1 Sld7 C-terminal domain Pkinase PF00069.25 AMD22983.1 - 2.4e-56 191.0 0.0 2.9e-56 190.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AMD22983.1 - 3.7e-15 55.9 0.0 6.2e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AMD22983.1 - 1.4e-07 31.7 0.0 5.2e-07 29.8 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AMD22983.1 - 0.008 15.8 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 AMD22983.1 - 0.058 12.2 0.0 0.094 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Ribosomal_L3 PF00297.22 AMD22984.1 - 5.2e-191 634.4 10.9 5.9e-191 634.3 10.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Tho1_MOS11_C PF18592.1 AMD22984.1 - 0.28 11.0 2.3 2.8 7.8 0.2 3.0 3 0 0 3 3 3 0 Tho1/MOS11 C-terminal domain PHD PF00628.29 AMD22985.1 - 0.00019 21.2 8.5 0.00019 21.2 8.5 1.8 1 1 1 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 AMD22985.1 - 0.018 15.3 3.7 0.033 14.5 3.7 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain FANCL_C PF11793.8 AMD22985.1 - 0.026 14.7 1.3 0.063 13.5 1.3 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.6 AMD22985.1 - 0.027 14.6 2.6 0.051 13.7 2.6 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain PHD_2 PF13831.6 AMD22985.1 - 0.57 9.8 9.0 0.52 9.9 2.8 2.4 2 0 0 2 2 2 0 PHD-finger DUF2116 PF09889.9 AMD22985.1 - 4.6 7.3 5.6 1.3 9.1 2.4 1.9 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Gln-synt_C PF00120.24 AMD22986.1 - 2e-19 69.8 0.0 1.7e-14 53.6 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 AMD22986.1 - 1.3e-13 50.4 0.0 2.4e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.14 AMD22987.1 - 5.6e-61 206.5 5.6 5.6e-61 206.5 5.6 1.9 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 AMD22987.1 - 8.3e-40 135.6 1.6 8.3e-40 135.6 1.6 2.8 4 0 0 4 4 4 1 V-ATPase subunit H Mo25 PF08569.11 AMD22987.1 - 1.4 8.2 8.8 4.3 6.6 0.3 3.4 3 1 0 4 4 4 0 Mo25-like Tropomyosin_1 PF12718.7 AMD22988.1 - 0.052 13.7 4.0 0.11 12.7 4.0 1.5 1 0 0 1 1 1 0 Tropomyosin like Csm1_N PF18504.1 AMD22988.1 - 0.058 13.7 4.0 0.069 13.5 2.1 2.1 2 0 0 2 2 2 0 Csm1 N-terminal domain Syntaxin-6_N PF09177.11 AMD22988.1 - 0.085 13.4 1.2 0.28 11.8 0.9 2.1 2 1 0 2 2 2 0 Syntaxin 6, N-terminal MerR-DNA-bind PF09278.11 AMD22988.1 - 0.093 13.3 1.8 7.3 7.2 0.9 2.5 2 0 0 2 2 2 0 MerR, DNA binding BLOC1_2 PF10046.9 AMD22988.1 - 0.1 12.9 1.1 0.29 11.4 0.5 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4407 PF14362.6 AMD22988.1 - 0.11 11.8 0.2 0.14 11.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 AMD22988.1 - 0.17 12.3 3.1 0.26 11.7 3.1 1.3 1 0 0 1 1 1 0 Fez1 PKcGMP_CC PF16808.5 AMD22988.1 - 0.26 11.2 2.4 0.66 9.9 2.4 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase PCI PF01399.27 AMD22989.1 - 0.00016 22.1 0.0 0.0005 20.5 0.0 1.9 1 1 0 1 1 1 1 PCI domain Sel1 PF08238.12 AMD22989.1 - 0.042 14.5 0.6 0.042 14.5 0.6 2.3 2 0 0 2 2 2 0 Sel1 repeat TPR_12 PF13424.6 AMD22989.1 - 0.062 13.6 1.0 0.12 12.7 0.3 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Tmemb_14 PF03647.13 AMD22990.1 - 9e-19 68.0 6.6 1.1e-18 67.7 6.6 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 AMD22990.1 - 1e-05 25.8 2.2 1.4e-05 25.4 2.2 1.2 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 G-gamma PF00631.22 AMD22991.1 - 4.8e-27 93.8 0.1 5.7e-27 93.5 0.1 1.1 1 0 0 1 1 1 1 GGL domain Evr1_Alr PF04777.13 AMD22992.1 - 1.3e-24 86.6 0.0 1.7e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Erv1 / Alr family SNAD4 PF18750.1 AMD22992.1 - 0.0028 17.8 0.1 0.0039 17.3 0.1 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC1 PF18769.1 AMD22992.1 - 0.022 15.0 0.1 0.032 14.5 0.1 1.3 1 0 0 1 1 1 0 APOBEC1 NAD1 PF18778.1 AMD22992.1 - 0.11 12.6 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 AMD22992.1 - 0.15 12.1 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 APOBEC2 TIP41 PF04176.13 AMD22993.1 - 3.7e-69 231.6 1.2 5.9e-69 231.0 1.2 1.3 1 0 0 1 1 1 1 TIP41-like family TPR_1 PF00515.28 AMD22994.1 - 8.7e-05 22.2 0.0 0.14 12.1 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 AMD22994.1 - 0.0001 22.2 0.2 0.015 15.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AMD22994.1 - 0.00015 21.7 1.4 0.13 12.6 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 AMD22994.1 - 0.015 16.0 0.0 0.37 11.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 AMD22994.1 - 0.11 12.2 1.3 0.23 11.1 0.2 2.1 3 0 0 3 3 3 0 TPR repeat eIF-5_eIF-2B PF01873.17 AMD22995.1 - 4.1e-38 129.9 0.0 7.6e-38 129.0 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 AMD22995.1 - 4.8e-21 74.7 2.8 6.7e-21 74.2 0.0 2.5 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon F-box-like PF12937.7 AMD22997.1 - 1.1e-06 28.4 0.1 2.5e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 AMD22997.1 - 1.1e-05 25.6 10.4 2.8 8.5 0.1 7.1 4 3 3 7 7 7 2 Leucine Rich repeats (2 copies) Preseq_ALAS PF09029.10 AMD22997.1 - 0.015 15.8 0.3 0.062 13.8 0.1 2.2 2 0 0 2 2 2 0 5-aminolevulinate synthase presequence LRR_6 PF13516.6 AMD22997.1 - 0.15 12.2 10.6 16 5.9 0.0 7.7 9 0 0 9 9 9 0 Leucine Rich repeat Occludin_ELL PF07303.13 AMD22997.1 - 0.48 11.2 2.2 12 6.6 0.1 3.4 3 0 0 3 3 3 0 Occludin homology domain Nucleoporin_N PF08801.11 AMD22998.1 - 5.6e-131 437.3 11.5 1e-130 436.4 10.2 2.0 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.14 AMD22998.1 - 5.2e-127 425.1 10.8 5e-125 418.5 10.8 2.1 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal GARS_A PF01071.19 AMD22998.1 - 0.082 12.7 0.2 0.58 9.9 0.0 2.3 2 1 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF3947 PF13135.6 AMD22998.1 - 0.27 11.5 3.3 1.5 9.1 3.3 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) Atg8 PF02991.16 AMD22999.1 - 7.5e-48 161.0 0.1 8.5e-48 160.8 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 AMD22999.1 - 1.8e-07 31.5 0.0 2.2e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Ish1 PF10281.9 AMD23000.1 - 0.011 16.0 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein FAM25 PF15825.5 AMD23000.1 - 0.079 13.3 2.3 0.088 13.2 2.3 1.2 1 0 0 1 1 1 0 FAM25 family MT0933_antitox PF14013.6 AMD23000.1 - 0.09 13.1 9.9 0.3 11.4 9.9 1.7 1 1 0 1 1 1 0 MT0933-like antitoxin protein SRP40_C PF05022.12 AMD23001.1 - 7.3e-23 81.2 2.8 7.3e-23 81.2 2.8 1.9 2 0 0 2 2 2 1 SRP40, C-terminal domain ERCC3_RAD25_C PF16203.5 AMD23002.1 - 1.6e-125 417.3 1.3 2.7e-125 416.6 1.3 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 AMD23002.1 - 1e-35 122.7 0.1 2.5e-35 121.4 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AMD23002.1 - 1.4e-15 57.7 0.0 2.9e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AMD23002.1 - 2.7e-12 47.0 0.2 8.5e-12 45.4 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 AMD23002.1 - 9.4e-09 34.4 0.0 1.2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 AMD23002.1 - 0.00037 20.3 0.0 0.0007 19.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.6 AMD23002.1 - 0.018 14.5 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein Cas_Csm6 PF09659.10 AMD23002.1 - 0.14 10.9 0.9 4 6.1 0.5 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csm6) CheY-binding PF09078.11 AMD23002.1 - 7.9 6.7 6.2 5.9 7.1 0.9 2.9 3 0 0 3 3 3 0 CheY binding Ndc80_HEC PF03801.13 AMD23003.1 - 1e-50 171.3 0.0 1e-50 171.3 0.0 2.4 2 0 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 AMD23003.1 - 4.9e-18 65.0 5.6 4.9e-18 65.0 5.6 4.9 4 2 2 6 6 6 2 Domain of unknown function (DUF5595) Spc7 PF08317.11 AMD23003.1 - 0.00056 18.9 43.3 0.017 14.0 24.7 2.5 2 0 0 2 2 2 2 Spc7 kinetochore protein Leu_zip PF15294.6 AMD23003.1 - 0.0066 16.0 20.0 0.0066 16.0 20.0 3.0 2 1 1 3 3 3 1 Leucine zipper NRN1 PF15056.6 AMD23003.1 - 0.2 11.8 1.9 0.47 10.6 0.8 2.3 2 0 0 2 2 2 0 Neuritin protein family ERM PF00769.19 AMD23003.1 - 0.49 10.2 38.0 2.2 8.0 22.5 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family TPR_MLP1_2 PF07926.12 AMD23003.1 - 1 9.4 41.6 0.31 11.1 3.8 3.8 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Cluap1 PF10234.9 AMD23003.1 - 1.9 7.8 0.0 1.9 7.8 0.0 4.8 4 2 1 5 5 5 0 Clusterin-associated protein-1 PriC PF07445.12 AMD23003.1 - 4.5 7.2 34.6 0.11 12.5 9.2 2.9 3 0 0 3 3 3 0 Primosomal replication protein priC Atg14 PF10186.9 AMD23003.1 - 7 5.6 36.1 3.6 6.6 9.6 2.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pantoate_ligase PF02569.15 AMD23004.1 - 2.1e-94 315.7 0.0 2.3e-94 315.5 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Myosin_TH1 PF06017.13 AMD23004.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding HATPase_c PF02518.26 AMD23006.1 - 2e-26 92.7 1.1 4.2e-24 85.2 1.1 2.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 AMD23006.1 - 1.3e-25 89.8 0.5 2.8e-25 88.7 0.5 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 AMD23006.1 - 2.4e-12 46.7 1.0 4.1e-12 45.9 0.1 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 AMD23006.1 - 7.8e-06 26.2 0.2 0.19 12.2 0.1 2.7 2 0 0 2 2 2 2 HAMP domain ubiquitin PF00240.23 AMD23007.1 - 4.1e-33 113.0 0.5 5.7e-33 112.5 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 AMD23007.1 - 2e-29 101.2 11.8 2e-29 101.2 11.8 1.8 2 0 0 2 2 2 1 Ribosomal L40e family Rad60-SLD PF11976.8 AMD23007.1 - 5.1e-15 55.1 0.5 7.8e-15 54.5 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AMD23007.1 - 0.00069 20.0 0.2 0.0028 18.1 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 AMD23007.1 - 0.0022 18.3 0.1 0.0034 17.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 AMD23007.1 - 0.0076 16.1 0.1 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 AMD23007.1 - 0.024 14.7 0.1 0.046 13.8 0.1 1.5 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 AMD23007.1 - 0.054 14.0 0.1 0.08 13.5 0.0 1.4 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain TPR_MLP1_2 PF07926.12 AMD23008.1 - 7.6e-31 106.8 25.2 7.6e-31 106.8 25.2 18.7 7 5 12 19 19 19 4 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 AMD23008.1 - 0.0075 16.5 12.8 0.0075 16.5 12.8 17.2 2 2 14 17 17 17 3 JNK_SAPK-associated protein-1 DcpS_C PF11969.8 AMD23008.1 - 3.5 8.1 6.4 5 7.6 0.2 4.1 3 0 0 3 3 3 0 Scavenger mRNA decapping enzyme C-term binding zf-primase PF09329.11 AMD23009.1 - 8e-13 48.0 0.4 1.5e-12 47.1 0.4 1.5 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.25 AMD23009.1 - 0.012 15.6 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DAGK_cat PF00781.24 AMD23010.1 - 6e-08 32.3 0.0 9.8e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pcc1 PF09341.10 AMD23011.1 - 3.3e-21 75.2 0.1 3.6e-21 75.1 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 PIN_4 PF13638.6 AMD23012.1 - 1.2e-13 51.5 0.1 1.2e-13 51.5 0.1 2.3 2 0 0 2 2 2 1 PIN domain Neur_chan_memb PF02932.16 AMD23012.1 - 4.7 7.2 6.1 0.49 10.4 1.2 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PEPCK_ATP PF01293.20 AMD23014.1 - 1.7e-217 722.7 0.0 2e-217 722.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 AMD23014.1 - 0.076 13.2 0.3 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain PTPA PF03095.15 AMD23015.1 - 6.8e-97 324.6 0.0 7.8e-97 324.3 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DAO PF01266.24 AMD23017.1 - 1.5e-50 172.8 0.0 2.6e-50 172.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 AMD23017.1 - 5.6e-42 142.6 0.0 1.3e-41 141.4 0.0 1.7 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 AMD23017.1 - 5.9e-12 45.4 4.9 3.9e-11 42.7 4.9 2.0 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AMD23017.1 - 4.7e-09 36.1 0.3 1.6e-06 27.8 0.3 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 AMD23017.1 - 8.2e-05 21.9 0.8 0.004 16.3 0.4 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 AMD23017.1 - 0.00014 21.2 0.1 0.00033 20.0 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AMD23017.1 - 0.00044 19.6 0.1 0.026 13.8 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 AMD23017.1 - 0.00089 18.1 0.6 0.0014 17.4 0.6 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 AMD23017.1 - 0.0014 18.8 0.7 0.0045 17.2 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 AMD23017.1 - 0.011 15.1 0.2 0.1 11.8 0.1 2.2 2 0 0 2 2 2 0 Thi4 family Pyr_redox_3 PF13738.6 AMD23017.1 - 0.033 13.4 0.0 0.07 12.4 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 AMD23017.1 - 0.12 12.2 1.7 0.46 10.3 1.5 2.0 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 AMD23017.1 - 0.14 12.6 0.0 0.37 11.3 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding UCH PF00443.29 AMD23018.1 - 7.5e-57 192.7 4.9 7.5e-57 192.7 4.9 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AMD23018.1 - 5.4e-19 68.9 6.3 5.4e-19 68.9 6.3 2.9 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 AMD23018.1 - 0.0034 17.9 0.0 0.01 16.3 0.0 1.9 1 0 0 1 1 1 1 Rhodanese-like domain Ribosomal_L37e PF01907.19 AMD23018.1 - 0.052 13.7 0.1 0.16 12.1 0.1 1.9 1 0 0 1 1 1 0 Ribosomal protein L37e Galactosyl_T PF01762.21 AMD23018.1 - 0.072 12.9 0.3 0.47 10.3 0.0 2.2 2 0 0 2 2 2 0 Galactosyltransferase Rubredoxin_2 PF18073.1 AMD23018.1 - 7.9 6.3 6.6 24 4.7 1.8 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain Myb_DNA-binding PF00249.31 AMD23019.1 - 4.6e-28 97.2 8.5 1.9e-11 44.0 0.8 3.6 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AMD23019.1 - 5.8e-27 93.7 2.0 3.9e-10 39.8 0.1 3.8 2 1 1 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 AMD23019.1 - 1.7e-05 24.8 0.1 0.21 11.6 0.0 2.8 1 1 2 3 3 3 2 SLIDE DUF1748 PF08520.10 AMD23020.1 - 9.9e-27 92.6 0.1 1.1e-26 92.5 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Coa1 PF08695.10 AMD23021.1 - 6.4e-38 129.1 0.0 8e-38 128.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 FH2 PF02181.23 AMD23023.1 - 1.6e-68 231.5 12.5 1.6e-68 231.5 12.5 2.5 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 AMD23023.1 - 2.9e-09 36.7 0.4 2.9e-09 36.7 0.4 3.5 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain LTXXQ PF07813.12 AMD23023.1 - 0.012 16.3 1.6 0.012 16.3 1.6 2.2 2 0 0 2 2 2 0 LTXXQ motif family protein DUF4709 PF15821.5 AMD23023.1 - 2.7 8.3 11.0 8.3 6.7 9.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4709) Thiolase_N PF00108.23 AMD23024.1 - 4.3e-78 262.3 0.7 6.7e-78 261.6 0.7 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AMD23024.1 - 1.1e-48 163.9 0.8 2.6e-48 162.7 0.8 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AMD23024.1 - 0.00012 21.7 0.9 0.00026 20.7 0.3 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 AMD23024.1 - 1.6 8.6 4.4 7.6 6.5 0.1 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Aldo_ket_red PF00248.21 AMD23025.1 - 2.8e-35 122.0 0.1 8.4e-33 113.8 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Sugar_tr PF00083.24 AMD23026.1 - 1.5e-72 245.0 27.3 1.7e-72 244.7 27.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AMD23026.1 - 7.2e-20 71.2 27.6 1.4e-19 70.3 21.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldo_ket_red PF00248.21 AMD23027.1 - 1.3e-45 155.9 0.0 7.4e-44 150.1 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family VAR1 PF05316.12 AMD23028.1 - 4.3e-41 141.1 52.0 4.3e-26 91.8 38.1 2.0 1 1 1 2 2 2 2 Mitochondrial ribosomal protein (VAR1) tRNA_synthFbeta PF17759.1 AMD23028.1 - 0.19 11.2 2.2 0.22 10.9 1.4 1.6 2 0 0 2 2 2 0 Phenylalanyl tRNA synthetase beta chain CLM domain Rol_Rep_N PF18106.1 AMD23028.1 - 3.1 8.2 6.9 1.1 9.6 0.9 2.6 2 0 0 2 2 2 0 Rolling Circle replication initiation protein N-terminal domain ATP-synt_C PF00137.21 AMD23029.1 - 2.3e-12 47.1 8.3 2.9e-12 46.7 8.3 1.1 1 0 0 1 1 1 1 ATP synthase subunit C MrpF_PhaF PF04066.13 AMD23029.1 - 0.01 16.2 0.3 0.01 16.2 0.3 2.5 1 1 1 2 2 2 1 Multiple resistance and pH regulation protein F (MrpF / PhaF) COX1 PF00115.20 AMD23030.1 - 1.2e-135 452.8 67.9 1.5e-135 452.5 67.9 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Fun_ATP-synt_8 PF05933.13 AMD23031.1 - 7.1e-23 80.5 10.2 7.7e-23 80.4 10.2 1.0 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) YMF19 PF02326.15 AMD23031.1 - 0.034 14.9 6.1 0.038 14.8 6.1 1.0 1 0 0 1 1 1 0 Plant ATP synthase F0 ATP-synt_A PF00119.20 AMD23032.1 - 6.3e-39 134.1 35.0 7.6e-39 133.8 35.0 1.0 1 0 0 1 1 1 1 ATP synthase A chain Cytochrome_B PF00033.19 AMD23033.1 - 4.7e-76 254.8 21.8 4.7e-76 254.8 21.8 2.1 2 1 0 2 2 2 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 AMD23033.1 - 8.8e-39 133.2 15.9 8.8e-39 133.2 15.9 2.6 3 0 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 AMD23033.1 - 2.3e-33 114.6 2.7 2.3e-33 114.6 2.7 3.5 3 1 0 3 3 3 1 Cytochrome b(C-terminal)/b6/petD COX2 PF00116.20 AMD23034.1 - 8.8e-59 196.7 0.1 1.7e-58 195.8 0.1 1.5 2 0 0 2 2 2 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.15 AMD23034.1 - 9.1e-31 105.9 2.3 1.7e-30 105.0 2.3 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain COX3 PF00510.18 AMD23035.1 - 6.2e-108 360.5 32.4 7e-108 360.3 32.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_sinecaudum-ASM154855v1/GCA_001548555.1_ASM154855v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_sinecaudum-ASM154855v1/GCA_001548555.1_ASM154855v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_sinecaudum-ASM154855v1/GCA_001548555.1_ASM154855v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_sinecaudum-ASM154855v1/GCA_001548555.1_ASM154855v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 19:09:23 2019 # [ok]