# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Asp PF00026.18 AMD18500.1 - 1.5e-67 228.1 0.0 1.8e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD18500.1 - 1e-06 28.8 0.0 2.5e-06 27.5 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Aldo_ket_red PF00248.16 AMD18501.1 - 4.1e-49 166.9 0.0 5e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FBPase PF00316.15 AMD18502.1 - 4.3e-134 446.4 0.0 4.8e-134 446.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Acyltransferase PF01553.16 AMD18503.1 - 7.9e-34 115.9 0.0 1.5e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase La PF05383.12 AMD18505.1 - 9.5e-22 76.5 0.1 2.3e-21 75.3 0.0 1.7 2 0 0 2 2 2 1 La domain RRM_6 PF14259.1 AMD18505.1 - 0.00085 19.2 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.7 AMD18505.1 - 0.034 13.7 0.2 0.077 12.5 0.1 1.6 1 0 0 1 1 1 0 BRCA1-associated protein 2 RRM_1 PF00076.17 AMD18505.1 - 0.092 12.3 0.1 0.24 11.0 0.1 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KRE9 PF05390.6 AMD18506.1 - 2.5e-43 146.8 3.3 2.5e-43 146.8 2.3 1.7 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.4 AMD18506.1 - 1e-12 48.3 0.1 2.4e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family NTP_transferase PF00483.18 AMD18507.1 - 8.9e-49 166.0 0.0 1.1e-48 165.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 AMD18507.1 - 6e-11 42.6 0.0 8.2e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 AMD18507.1 - 2.6e-10 39.2 5.1 4.4e-07 29.1 0.9 3.7 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 AMD18507.1 - 0.051 13.1 8.1 0.083 12.4 0.8 3.1 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.14 AMD18507.1 - 0.17 11.5 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase Ank_4 PF13637.1 AMD18508.1 - 1.9e-14 53.7 0.0 1.2e-05 25.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD18508.1 - 5.6e-13 49.0 0.2 4.7e-06 26.8 0.0 3.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 AMD18508.1 - 1.4e-11 44.2 0.2 0.00047 20.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 AMD18508.1 - 3.1e-11 42.4 0.3 0.00056 19.5 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 AMD18508.1 - 1.2e-07 31.2 0.1 0.053 13.7 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.8 AMD18508.1 - 7.5e-07 28.7 2.7 1.7e-06 27.6 0.1 2.8 2 1 0 2 2 2 1 KilA-N domain Y_phosphatase3 PF13350.1 AMD18509.1 - 8.6e-40 136.6 0.0 1.4e-39 135.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Abhydrolase_5 PF12695.2 AMD18509.1 - 1e-13 51.2 0.0 1.5e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 AMD18509.1 - 1.5e-09 38.1 0.0 4e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Y_phosphatase3C PF13348.1 AMD18509.1 - 9.7e-09 35.2 0.0 2.9e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region Hydrolase_4 PF12146.3 AMD18509.1 - 7.1e-05 22.5 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Y_phosphatase2 PF03162.8 AMD18509.1 - 0.0075 15.6 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 AMD18509.1 - 0.022 14.1 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 AMD18509.1 - 0.099 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Sugar_tr PF00083.19 AMD18510.1 - 4.3e-122 407.9 35.0 4.9e-122 407.7 24.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD18510.1 - 1.2e-20 73.5 39.3 1.9e-18 66.3 18.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MutS_V PF00488.16 AMD18511.1 - 2.9e-96 321.4 0.2 5e-96 320.6 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 AMD18511.1 - 1.5e-33 116.3 4.7 2.5e-33 115.6 0.7 2.9 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.12 AMD18511.1 - 4.5e-18 65.6 0.1 4.5e-18 65.6 0.0 2.8 4 0 0 4 4 4 1 MutS domain II MutS_IV PF05190.13 AMD18511.1 - 3.1e-17 62.5 3.5 4.6e-17 61.9 0.9 2.6 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.15 AMD18511.1 - 1.1e-09 38.2 0.1 3.1e-09 36.8 0.0 1.8 2 0 0 2 2 2 1 MutS domain I DUF4381 PF14316.1 AMD18511.1 - 0.027 14.5 2.3 0.086 12.9 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4381) HALZ PF02183.13 AMD18512.1 - 0.02 14.5 1.3 0.02 14.5 0.9 6.0 6 1 0 6 6 6 0 Homeobox associated leucine zipper Reo_sigmaC PF04582.7 AMD18512.1 - 1.4 8.0 8.1 0.14 11.2 1.3 2.4 3 0 0 3 3 3 0 Reovirus sigma C capsid protein tRNA_m1G_MT PF01746.16 AMD18513.1 - 9.7e-37 126.3 0.1 1.7e-36 125.5 0.1 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Glyco_hydro_67C PF07477.7 AMD18513.1 - 0.13 11.6 1.6 0.27 10.6 1.1 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 C-terminus Rep_fac_C PF08542.6 AMD18514.1 - 1.9e-19 69.4 0.3 1.2e-18 66.9 0.0 2.3 3 0 0 3 3 2 1 Replication factor C C-terminal domain AAA PF00004.24 AMD18514.1 - 8.3e-13 48.6 0.0 3.2e-12 46.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 AMD18514.1 - 2.5e-12 46.7 0.0 2.7e-10 40.1 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 AMD18514.1 - 3.5e-08 32.5 0.1 0.00061 18.5 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_14 PF13173.1 AMD18514.1 - 2.4e-07 30.7 0.0 6.3e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 AMD18514.1 - 1.4e-06 28.4 0.0 6.9e-05 22.9 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 AMD18514.1 - 4.2e-06 26.9 0.1 0.053 13.6 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_3 PF07726.6 AMD18514.1 - 1.8e-05 24.3 0.0 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD18514.1 - 1.9e-05 23.8 0.0 9.1e-05 21.6 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Viral_helicase1 PF01443.13 AMD18514.1 - 7.8e-05 22.2 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.16 AMD18514.1 - 0.00032 19.9 0.0 0.0027 16.8 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 AMD18514.1 - 0.00067 19.1 0.0 0.085 12.2 0.0 2.4 1 1 1 2 2 2 1 AAA-like domain DNA_pol3_delta PF06144.8 AMD18514.1 - 0.0018 17.8 0.2 0.0031 17.0 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit FtsK_SpoIIIE PF01580.13 AMD18514.1 - 0.0059 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_19 PF13245.1 AMD18514.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain NTPase_1 PF03266.10 AMD18514.1 - 0.013 15.1 0.1 0.11 12.1 0.0 2.2 1 1 1 2 2 2 0 NTPase ArgK PF03308.11 AMD18514.1 - 0.016 14.0 0.0 0.094 11.4 0.0 2.1 1 1 1 2 2 2 0 ArgK protein DEAD PF00270.24 AMD18514.1 - 0.029 13.8 0.1 0.33 10.4 0.0 2.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_11 PF13086.1 AMD18514.1 - 0.063 12.8 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.1 AMD18514.1 - 0.067 13.1 0.0 0.36 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 AMD18514.1 - 0.088 13.1 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 AMD18514.1 - 0.092 11.9 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NACHT PF05729.7 AMD18514.1 - 0.11 12.1 0.1 0.64 9.6 0.0 2.2 2 1 0 2 2 1 0 NACHT domain AAA_30 PF13604.1 AMD18514.1 - 0.15 11.6 0.1 2 7.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain Vps52 PF04129.7 AMD18515.1 - 8e-133 443.6 19.1 1.1e-132 443.2 13.2 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family UvrD-helicase PF00580.16 AMD18516.1 - 3.7e-27 95.4 0.7 1e-16 61.1 0.2 2.7 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 AMD18516.1 - 3.5e-20 72.7 2.6 3.5e-20 72.7 1.8 2.6 2 2 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 AMD18516.1 - 5.5e-07 29.2 0.0 1.5e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain UvrD_C_2 PF13538.1 AMD18516.1 - 9e-07 28.9 0.0 2.7e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.1 AMD18516.1 - 0.00077 19.0 0.0 0.0023 17.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 AMD18516.1 - 0.0011 18.5 0.4 0.23 10.9 0.0 3.6 3 2 1 4 4 4 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.1 AMD18516.1 - 0.0013 18.3 1.1 0.01 15.4 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 AMD18516.1 - 0.0045 17.1 4.8 0.49 10.5 1.1 4.1 3 1 0 3 3 3 1 AAA domain DUF2075 PF09848.4 AMD18516.1 - 0.013 14.4 2.9 0.031 13.2 0.8 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.11 AMD18516.1 - 0.041 13.1 0.1 0.097 11.8 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein T2SE PF00437.15 AMD18516.1 - 0.049 12.5 0.0 0.11 11.3 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Helicase_RecD PF05127.9 AMD18516.1 - 0.085 12.4 0.0 0.24 11.0 0.0 1.8 1 0 0 1 1 1 0 Helicase YL1 PF05764.8 AMD18517.1 - 1.7e-52 178.4 34.7 1.7e-52 178.4 24.1 2.2 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.6 AMD18517.1 - 2.9e-11 42.7 0.1 4.5e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Methyltransf_23 PF13489.1 AMD18518.1 - 5.4e-23 81.4 0.0 8.9e-23 80.7 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD18518.1 - 2.6e-13 50.2 0.0 5.5e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD18518.1 - 5.1e-13 48.8 0.0 8.4e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD18518.1 - 4e-12 46.4 0.0 1.8e-11 44.3 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD18518.1 - 7.4e-12 45.8 0.0 1.5e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 AMD18518.1 - 6.1e-06 25.7 0.0 8.9e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_25 PF13649.1 AMD18518.1 - 8.8e-06 26.0 0.0 1.5e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 AMD18518.1 - 5.4e-05 22.4 0.0 7.8e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 AMD18518.1 - 0.0005 19.2 0.0 0.00062 18.9 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.8 AMD18518.1 - 0.0005 19.2 0.0 0.00073 18.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 AMD18518.1 - 0.0012 18.1 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 AMD18518.1 - 0.0057 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Spermine_synth PF01564.12 AMD18518.1 - 0.0063 15.4 0.0 0.0094 14.9 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_26 PF13659.1 AMD18518.1 - 0.007 16.3 0.0 0.014 15.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 AMD18518.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB DREV PF05219.7 AMD18518.1 - 0.067 12.0 0.0 0.17 10.7 0.0 1.8 2 0 0 2 2 2 0 DREV methyltransferase Snf7 PF03357.16 AMD18519.1 - 1.3e-39 135.2 20.7 1.6e-39 135.0 14.3 1.0 1 0 0 1 1 1 1 Snf7 Prefoldin PF02996.12 AMD18519.1 - 0.0098 15.5 0.4 0.0098 15.5 0.3 3.5 1 1 2 3 3 3 1 Prefoldin subunit MscS_porin PF12795.2 AMD18519.1 - 0.032 13.5 27.6 0.69 9.1 13.5 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain 2OG-FeII_Oxy_2 PF13532.1 AMD18519.1 - 0.076 12.8 0.8 0.11 12.2 0.6 1.2 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Fmp27_WPPW PF10359.4 AMD18519.1 - 0.076 11.4 12.3 0.36 9.1 8.5 1.8 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Mnd1 PF03962.10 AMD18519.1 - 0.45 10.1 16.9 1.2 8.7 7.6 2.2 1 1 2 3 3 3 0 Mnd1 family Peptidase_S46 PF10459.4 AMD18519.1 - 0.67 8.3 11.6 0.8 8.0 8.1 1.0 1 0 0 1 1 1 0 Peptidase S46 Prefoldin_2 PF01920.15 AMD18519.1 - 1.6 8.5 21.4 0.14 11.9 0.4 3.2 1 1 2 3 3 3 0 Prefoldin subunit Reo_sigmaC PF04582.7 AMD18519.1 - 2 7.5 8.6 3.4 6.7 3.0 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF713 PF05218.9 AMD18519.1 - 3.3 7.4 10.5 3.8 7.1 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF713) Cep57_MT_bd PF06657.8 AMD18519.1 - 4 7.4 17.0 2.2 8.2 3.9 2.8 1 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Seryl_tRNA_N PF02403.17 AMD18519.1 - 4.4 7.3 20.0 3 7.8 0.9 3.1 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF972 PF06156.8 AMD18519.1 - 5.2 7.4 18.0 11 6.3 1.7 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Exonuc_VII_L PF02601.10 AMD18519.1 - 6.1 5.9 15.5 13 4.8 10.7 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Serine_rich PF08824.5 AMD18519.1 - 9.1 5.9 14.6 6.5 6.4 6.3 2.9 1 1 2 3 3 3 0 Serine rich protein interaction domain Nup88 PF10168.4 AMD18519.1 - 9.2 3.9 15.0 1.9 6.2 1.4 2.0 1 1 1 2 2 2 0 Nuclear pore component tRNA-synt_1b PF00579.20 AMD18520.1 - 8.8e-18 64.4 0.0 4.4e-12 45.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) DHBP_synthase PF00926.14 AMD18521.1 - 4.1e-75 251.2 0.0 4.6e-75 251.1 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase K_channel_TID PF07941.6 AMD18522.1 - 1.1 9.4 8.8 0.16 12.2 1.0 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain SecY PF00344.15 AMD18523.1 - 1.3e-89 300.5 11.9 1.6e-89 300.2 8.3 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 AMD18523.1 - 2.3e-17 62.1 0.2 2.3e-17 62.1 0.1 2.5 2 0 0 2 2 2 1 Plug domain of Sec61p Glyco_hydro_85 PF03644.8 AMD18524.1 - 3e-62 210.5 2.3 4.9e-62 209.8 1.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Transp_cyt_pur PF02133.10 AMD18525.1 - 2.2e-140 468.0 42.2 2.6e-140 467.8 29.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin zf-C2H2 PF00096.21 AMD18526.1 - 0.00078 19.6 1.8 0.00078 19.6 1.3 5.2 4 1 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD18526.1 - 0.0016 18.6 21.2 0.0025 18.0 0.8 5.1 5 1 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AMD18526.1 - 0.0042 16.9 9.7 0.24 11.3 0.2 4.2 3 1 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD18526.1 - 0.0058 16.8 0.5 0.0058 16.8 0.3 5.1 4 1 1 5 5 5 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 AMD18526.1 - 0.1 12.7 0.1 0.1 12.7 0.1 4.0 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.9 AMD18526.1 - 6.5 6.4 8.6 4.4 7.0 0.9 3.1 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-Sec23_Sec24 PF04810.10 AMD18526.1 - 8 6.1 7.6 49 3.6 0.2 4.0 5 0 0 5 5 5 0 Sec23/Sec24 zinc finger zf-BED PF02892.10 AMD18527.1 - 8.1e-05 22.2 8.6 0.00021 20.9 6.0 1.8 1 0 0 1 1 1 1 BED zinc finger zf-IS66 PF13005.2 AMD18527.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 zinc-finger binding domain of transposase IS66 ELO PF01151.13 AMD18528.1 - 2.4e-60 203.9 25.2 3e-60 203.6 17.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CNH PF00780.17 AMD18529.1 - 1.3e-78 264.2 0.5 2.7e-78 263.1 0.1 1.7 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.1 AMD18529.1 - 2e-37 128.1 0.0 7.2e-37 126.3 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.15 AMD18529.1 - 4.6e-33 114.6 0.4 4.6e-33 114.6 0.3 2.0 3 0 0 3 3 3 1 RhoGEF domain DEP PF00610.16 AMD18529.1 - 8.6e-14 51.0 0.0 1.9e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) P21-Arc PF04062.9 AMD18530.1 - 2.9e-80 268.1 0.1 3.2e-80 267.9 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit HSP70 PF00012.15 AMD18531.1 - 1.4e-212 706.8 10.6 1.7e-212 706.6 7.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 AMD18531.1 - 1.7e-17 63.0 6.6 7.8e-16 57.5 1.6 2.6 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 AMD18531.1 - 2.4e-06 27.2 0.0 5.6e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.15 AMD18531.1 - 0.00065 19.0 0.0 0.078 12.2 0.0 2.9 1 1 1 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.1 AMD18531.1 - 0.0014 18.4 7.2 0.12 12.2 0.0 3.8 4 0 0 4 4 4 2 Cell division protein FtsA DUF948 PF06103.6 AMD18531.1 - 0.024 14.4 1.0 0.1 12.4 0.7 2.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) F-box-like PF12937.2 AMD18532.1 - 0.00052 19.6 3.0 0.0017 18.0 2.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 AMD18532.1 - 0.002 17.7 2.3 0.01 15.4 1.6 2.4 1 0 0 1 1 1 1 F-box domain Arrestin_C PF02752.17 AMD18533.1 - 8.6e-08 32.3 0.0 5.6e-07 29.7 0.0 2.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 AMD18533.1 - 0.00011 22.0 0.0 0.00045 20.0 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain zf-C2H2 PF00096.21 AMD18534.1 - 1.7e-07 31.1 13.4 9e-05 22.5 1.7 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD18534.1 - 6.4e-06 26.1 19.5 0.00084 19.4 1.5 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD18534.1 - 0.00021 21.4 16.6 0.00032 20.8 3.3 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-H2C2_5 PF13909.1 AMD18534.1 - 0.19 12.0 6.9 0.041 14.1 1.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.3 AMD18534.1 - 1.1 9.4 6.3 14 6.0 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Ribosomal_S8 PF00410.14 AMD18535.1 - 1e-25 90.0 0.0 1.4e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 DUF1995 PF09353.5 AMD18535.1 - 0.063 12.9 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1995) MFS_1 PF07690.11 AMD18536.1 - 4.1e-17 61.9 21.2 4.1e-17 61.9 14.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glutaredoxin PF00462.19 AMD18537.1 - 7.3e-08 32.2 0.0 2e-07 30.8 0.0 1.8 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.1 AMD18537.1 - 0.015 15.4 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_9 PF14595.1 AMD18537.1 - 0.036 13.6 0.2 0.045 13.3 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin DUF953 PF06110.6 AMD18537.1 - 0.043 13.2 0.6 0.056 12.8 0.4 1.4 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Glyco_hydro_10 PF00331.15 AMD18537.1 - 0.082 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 CesA PF11439.3 AMD18537.1 - 0.087 12.7 0.1 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Type III secretion system filament chaperone CesA Thioredoxin_3 PF13192.1 AMD18537.1 - 0.15 11.9 0.0 0.4 10.5 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin domain Spt4 PF06093.8 AMD18538.1 - 3.8e-29 100.3 0.4 4.5e-29 100.1 0.3 1.0 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger 60KD_IMP PF02096.15 AMD18539.1 - 5.4e-14 52.3 9.9 7.5e-13 48.5 6.9 2.0 1 1 0 1 1 1 1 60Kd inner membrane protein DUF2462 PF09495.5 AMD18540.1 - 9.5e-20 71.1 10.6 1.3e-19 70.6 7.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) Kunitz_legume PF00197.13 AMD18540.1 - 0.097 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Trypsin and protease inhibitor GATase_5 PF13507.1 AMD18541.1 - 4e-98 327.4 0.1 5.8e-98 326.9 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 AMD18541.1 - 1.6e-47 161.3 0.9 6.7e-29 100.8 0.1 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 AMD18541.1 - 8.2e-23 80.4 0.0 2.3e-22 79.0 0.0 1.8 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain FA_hydroxylase PF04116.8 AMD18542.1 - 1.2e-15 57.8 21.7 1.2e-15 57.8 15.0 2.0 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Septin PF00735.13 AMD18543.1 - 2.4e-96 322.0 0.1 5.1e-96 321.0 0.1 1.5 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 AMD18543.1 - 1e-05 25.4 0.0 2.6e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 AMD18543.1 - 7.6e-05 21.9 0.4 0.0022 17.1 0.1 2.6 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 AMD18543.1 - 0.00011 21.4 0.1 0.00046 19.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 AMD18543.1 - 0.00035 20.4 2.7 0.06 13.1 0.0 3.2 2 1 0 3 3 3 2 Dynamin family GTP_EFTU PF00009.22 AMD18543.1 - 0.0023 17.3 0.5 1.1 8.6 0.1 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.13 AMD18543.1 - 0.0077 15.7 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family T2SE PF00437.15 AMD18543.1 - 0.016 14.1 0.0 0.027 13.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Miro PF08477.8 AMD18543.1 - 0.027 14.9 0.0 0.097 13.1 0.0 2.0 1 0 0 1 1 1 0 Miro-like protein AAA_24 PF13479.1 AMD18543.1 - 0.039 13.5 0.0 0.11 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 AMD18543.1 - 0.093 12.4 0.3 0.38 10.4 0.2 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF87 PF01935.12 AMD18543.1 - 2.8 7.7 7.5 0.74 9.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function DUF87 EF-hand_7 PF13499.1 AMD18544.1 - 3.5e-08 33.4 0.9 0.0033 17.5 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 AMD18544.1 - 0.00095 18.8 0.9 2.1 8.4 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 AMD18544.1 - 0.013 14.7 0.0 25 4.5 0.0 4.0 4 0 0 4 4 4 0 EF hand S10_plectin PF03501.10 AMD18545.1 - 5.1e-42 141.6 0.2 6e-42 141.4 0.1 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF505 PF04458.7 AMD18545.1 - 0.073 11.1 0.1 0.08 11.0 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF505) PadR PF03551.9 AMD18545.1 - 2.8 7.7 5.7 0.45 10.3 1.2 1.8 2 1 0 2 2 2 0 Transcriptional regulator PadR-like family Mpv17_PMP22 PF04117.7 AMD18546.1 - 7.3e-20 70.3 0.6 7.3e-20 70.3 0.4 2.0 2 0 0 2 2 2 1 Mpv17 / PMP22 family P5-ATPase PF12409.3 AMD18547.1 - 5.8e-38 129.3 1.2 5.8e-38 129.3 0.8 2.4 3 0 0 3 3 3 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.15 AMD18547.1 - 6.4e-30 103.8 0.0 1.7e-29 102.5 0.0 1.7 2 0 0 2 2 2 1 E1-E2 ATPase HAD PF12710.2 AMD18547.1 - 4.8e-24 85.6 0.0 8.8e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AMD18547.1 - 2.3e-15 57.6 0.0 3.5e-14 53.7 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 AMD18547.1 - 0.0003 20.6 0.0 0.00068 19.5 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 AMD18547.1 - 0.0029 17.0 0.0 0.0069 15.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 AMD18547.1 - 0.0043 16.6 0.1 0.4 10.2 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S1 PF00575.18 AMD18548.1 - 3.7e-68 225.5 28.6 1.5e-13 50.6 0.7 12.7 13 0 0 13 13 13 11 S1 RNA binding domain TPR_19 PF14559.1 AMD18548.1 - 1.1e-05 25.6 0.1 0.66 10.3 0.1 4.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 AMD18548.1 - 0.0002 21.9 0.0 0.3 11.8 0.0 3.0 2 1 1 3 3 3 3 Tetratricopeptide repeat Suf PF05843.9 AMD18548.1 - 0.0011 18.7 2.0 0.0011 18.7 1.4 4.7 3 1 2 5 5 5 3 Suppressor of forked protein (Suf) TPR_14 PF13428.1 AMD18548.1 - 0.0014 19.0 0.2 9.4 7.1 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat RrnaAD PF00398.15 AMD18550.1 - 1.6e-41 142.1 0.1 1.9e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TAFII55_N PF04658.8 AMD18551.1 - 1.1e-56 190.8 0.1 1.1e-56 190.8 0.1 2.8 3 0 0 3 3 3 1 TAFII55 protein conserved region Zip PF02535.17 AMD18551.1 - 3.2 6.6 14.0 0.065 12.2 2.9 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter SNF2_N PF00176.18 AMD18552.1 - 1.5e-81 273.4 0.2 1.5e-81 273.4 0.1 3.0 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD18552.1 - 2.7e-16 59.1 0.0 2.7e-16 59.1 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.1 AMD18552.1 - 5e-16 58.6 0.6 5e-16 58.6 0.4 4.0 4 1 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex Bromodomain PF00439.20 AMD18552.1 - 6.2e-14 51.6 2.0 8.3e-14 51.2 0.1 2.2 2 0 0 2 2 2 1 Bromodomain Med15 PF09606.5 AMD18552.1 - 0.15 10.2 106.5 0.24 9.5 73.8 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Mem_trans PF03547.13 AMD18552.1 - 6.4 4.9 4.9 15 3.7 3.4 1.5 1 0 0 1 1 1 0 Membrane transport protein adh_short PF00106.20 AMD18553.1 - 4.6e-33 114.5 0.0 6.5e-33 114.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AMD18553.1 - 3.1e-17 63.1 0.0 3.9e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AMD18553.1 - 2.8e-13 49.9 0.0 4e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 AMD18553.1 - 4e-05 23.1 0.1 8.9e-05 22.0 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 AMD18553.1 - 4.8e-05 22.6 0.0 9.9e-05 21.6 0.0 1.4 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.10 AMD18553.1 - 7.7e-05 21.7 0.1 0.00012 21.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 AMD18553.1 - 0.0002 21.0 0.1 0.00047 19.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Saccharop_dh PF03435.13 AMD18553.1 - 0.00056 19.0 0.1 0.00085 18.4 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_10 PF13460.1 AMD18553.1 - 0.0042 17.1 0.3 0.0071 16.3 0.2 1.5 1 1 0 1 1 1 1 NADH(P)-binding Hpr_kinase_C PF07475.7 AMD18553.1 - 0.036 13.3 0.7 4.6 6.5 0.0 3.0 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain Shikimate_DH PF01488.15 AMD18553.1 - 0.1 12.7 0.3 0.27 11.3 0.2 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rhodanese PF00581.15 AMD18554.1 - 4e-15 56.1 0.0 6.2e-15 55.5 0.0 1.3 1 1 0 1 1 1 1 Rhodanese-like domain VHP PF02209.14 AMD18554.1 - 0.074 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Villin headpiece domain DUF947 PF06102.7 AMD18555.1 - 1.3e-41 142.2 32.5 1.3e-41 142.2 22.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF947) MRP_L53 PF10780.4 AMD18556.1 - 4.8e-16 58.4 0.1 6.5e-16 58.0 0.1 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Thioredoxin PF00085.15 AMD18557.1 - 5.1e-20 71.0 0.1 9.3e-20 70.2 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 AMD18557.1 - 3.9e-06 27.0 2.4 3.9e-06 27.0 0.3 2.0 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 AMD18557.1 - 0.00015 21.7 0.1 0.00029 20.7 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.1 AMD18557.1 - 0.001 19.1 0.1 0.33 11.1 0.1 2.8 1 1 1 2 2 2 2 Thioredoxin-like AMMECR1 PF01871.12 AMD18558.1 - 7.5e-37 126.0 0.0 1e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 His_Phos_1 PF00300.17 AMD18559.1 - 2.2e-33 115.5 0.2 2.7e-33 115.2 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF4142 PF13628.1 AMD18559.1 - 0.023 14.7 0.1 0.78 9.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) SF-assemblin PF06705.6 AMD18559.1 - 0.025 13.7 0.3 0.036 13.2 0.2 1.3 1 0 0 1 1 1 0 SF-assemblin/beta giardin Mre11_DNA_bind PF04152.9 AMD18560.1 - 2.3e-50 170.8 0.1 2.3e-50 170.8 0.1 2.7 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 AMD18560.1 - 1.8e-28 99.2 0.6 3.4e-28 98.4 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 AMD18560.1 - 1.7e-05 24.6 0.0 4.3e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain F_bP_aldolase PF01116.15 AMD18560.1 - 0.069 12.2 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II Phosducin PF02114.11 AMD18561.1 - 3.3e-15 55.5 0.9 4.4e-15 55.1 0.6 1.2 1 0 0 1 1 1 1 Phosducin APG6 PF04111.7 AMD18561.1 - 0.061 12.3 2.8 0.1 11.6 1.9 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 Flavodoxin_2 PF02525.12 AMD18561.1 - 0.064 12.7 0.3 0.48 9.9 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin-like fold UCH PF00443.24 AMD18562.1 - 1.2e-58 198.3 0.1 1.6e-58 198.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD18562.1 - 6.9e-29 101.2 0.0 3.7e-28 98.8 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 AMD18562.1 - 3.1e-11 43.2 7.1 3.1e-11 43.2 4.9 2.5 2 1 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein FSH1 PF03959.8 AMD18563.1 - 8.3e-57 192.0 0.0 9.3e-57 191.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 AMD18563.1 - 1.5e-06 27.9 0.0 2.5e-06 27.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 AMD18563.1 - 0.00014 21.3 0.0 0.00051 19.5 0.0 1.9 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 AMD18563.1 - 0.01 15.6 0.0 4.3 7.1 0.0 2.2 1 1 1 2 2 2 0 Alpha/beta hydrolase family FSH1 PF03959.8 AMD18564.1 - 9.4e-66 221.2 0.0 1.1e-65 221.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 AMD18564.1 - 3.2e-07 30.2 0.0 4.4e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 AMD18564.1 - 0.0013 18.2 0.1 0.0035 16.8 0.1 1.9 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 AMD18564.1 - 0.0053 16.6 0.1 2.1 8.1 0.0 2.6 1 1 1 2 2 2 2 Alpha/beta hydrolase family GHMP_kinases_N PF00288.21 AMD18566.1 - 2.8e-13 49.7 0.0 5.7e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 AMD18566.1 - 0.0001 22.4 0.0 0.00027 21.0 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal TRAPPC10 PF12584.3 AMD18568.1 - 2.6e-14 52.9 0.0 4.8e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 HEM4 PF02602.10 AMD18569.1 - 5.2e-42 143.6 0.0 5.9e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Med20 PF08612.6 AMD18569.1 - 0.0049 16.0 0.0 0.0079 15.3 0.0 1.3 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex GMP_synt_C PF00958.17 AMD18570.1 - 3.4e-41 138.8 0.0 7.8e-41 137.7 0.0 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.23 AMD18570.1 - 3.7e-41 140.6 0.0 7.1e-41 139.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 AMD18570.1 - 6.2e-08 31.8 0.0 7.1e-06 25.1 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 AMD18570.1 - 1.1e-07 31.4 0.1 4.1e-07 29.6 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.11 AMD18570.1 - 0.0032 16.0 0.0 0.0068 15.0 0.0 1.5 1 0 0 1 1 1 1 tRNA methyl transferase PAPS_reduct PF01507.14 AMD18570.1 - 0.022 14.5 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family QueC PF06508.8 AMD18570.1 - 0.023 14.0 0.0 0.43 9.8 0.0 2.2 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.14 AMD18570.1 - 0.036 13.1 0.1 0.065 12.2 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ThiI PF02568.9 AMD18570.1 - 0.039 13.4 0.0 0.09 12.2 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) Asn_synthase PF00733.16 AMD18570.1 - 0.047 13.1 0.0 0.083 12.3 0.0 1.4 1 0 0 1 1 1 0 Asparagine synthase RRM_1 PF00076.17 AMD18571.1 - 4.6e-11 42.1 0.0 9.1e-11 41.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 AMD18571.1 - 1.4e-09 37.6 0.0 2.3e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_6 PF14259.1 AMD18571.1 - 5.6e-09 35.8 0.0 1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD18571.1 - 1e-06 28.4 0.0 1.7e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 AMD18572.1 - 1.5e-39 135.7 1.2 1.5e-19 70.1 0.9 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18572.1 - 3.9e-10 39.2 1.6 7.5e-06 25.1 0.7 3.2 2 1 0 2 2 2 2 Protein tyrosine kinase Glyco_hydro_72 PF03198.9 AMD18573.1 - 1.7e-114 382.0 0.4 2.7e-114 381.4 0.3 1.3 1 0 0 1 1 1 1 Glucanosyltransferase DnaJ PF00226.26 AMD18574.1 - 2.1e-28 97.8 1.5 3.3e-28 97.1 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 AMD18574.1 - 5.1e-16 58.4 18.4 8.6e-16 57.7 12.7 1.4 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 AMD18574.1 - 1.5e-12 47.2 0.0 4.8e-11 42.3 0.0 2.6 3 0 0 3 3 3 1 DnaJ C terminal domain A2L_zn_ribbon PF08792.5 AMD18574.1 - 0.41 10.1 10.1 4.7 6.8 0.6 3.5 2 1 1 3 3 3 0 A2L zinc ribbon domain DZR PF12773.2 AMD18574.1 - 5.4 6.9 14.3 3.4e+02 1.1 9.9 2.3 1 1 0 1 1 1 0 Double zinc ribbon PADR1 PF08063.7 AMD18574.1 - 8.1 5.9 12.1 11 5.4 0.1 3.4 1 1 2 3 3 3 0 PADR1 (NUC008) domain DUF776 PF05604.6 AMD18575.1 - 0.0014 18.9 0.1 0.002 18.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF776) DUF844 PF05815.6 AMD18575.1 - 0.041 12.7 0.1 0.047 12.5 0.1 1.1 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF844) DUF2849 PF11011.3 AMD18575.1 - 0.073 13.3 0.4 2.8 8.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2849) Myb_DNA-binding PF00249.26 AMD18576.1 - 2.2e-22 78.8 7.1 4.2e-13 49.1 0.3 3.5 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD18576.1 - 1.9e-20 72.7 5.6 4.7e-14 52.2 1.8 4.0 3 1 1 4 4 4 2 Myb-like DNA-binding domain Rap1_C PF11626.3 AMD18576.1 - 0.0012 18.7 2.1 0.033 14.0 0.0 3.4 3 1 0 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain LMP PF04778.7 AMD18577.1 - 1.6 8.4 6.8 0.31 10.7 1.7 2.0 2 0 0 2 2 2 0 LMP repeated region BRO1 PF03097.13 AMD18578.1 - 2.9e-83 279.7 4.8 2.9e-83 279.7 3.3 1.7 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 AMD18578.1 - 9.9e-19 67.4 24.7 1.1e-12 47.6 6.3 2.8 3 0 0 3 3 3 2 ALIX V-shaped domain binding to HIV Homoserine_dh PF00742.14 AMD18578.1 - 0.21 11.2 1.7 1.3 8.6 0.1 2.2 2 0 0 2 2 2 0 Homoserine dehydrogenase IPPT PF01715.12 AMD18579.1 - 8e-80 267.5 1.2 1.1e-79 267.0 0.8 1.1 1 0 0 1 1 1 1 IPP transferase AAA_17 PF13207.1 AMD18579.1 - 7.4e-06 26.7 0.5 4.1e-05 24.3 0.3 2.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD18579.1 - 0.00018 21.7 0.5 0.0022 18.3 0.2 2.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AMD18579.1 - 0.0003 20.6 0.0 0.0017 18.2 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 AMD18579.1 - 0.00058 20.0 0.2 0.15 12.1 0.0 3.0 2 1 1 3 3 3 1 AAA domain IPT PF01745.11 AMD18579.1 - 0.00087 18.5 0.6 0.0063 15.7 0.0 2.5 3 1 1 4 4 4 1 Isopentenyl transferase Zeta_toxin PF06414.7 AMD18579.1 - 0.0023 17.0 0.0 0.0056 15.7 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.1 AMD18579.1 - 0.0059 16.0 0.0 0.012 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 AMD18579.1 - 0.019 15.1 0.0 0.063 13.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase CbiA PF01656.18 AMD18579.1 - 0.078 12.3 0.1 0.23 10.8 0.1 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF258 PF03193.11 AMD18579.1 - 0.094 11.9 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Hpr_kinase_C PF07475.7 AMD18579.1 - 0.12 11.7 0.7 0.32 10.2 0.0 2.0 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain Tubulin_3 PF14881.1 AMD18580.1 - 3.5e-21 75.4 0.0 9.7e-21 74.0 0.0 1.8 1 1 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 AMD18580.1 - 9.4e-13 48.2 0.1 4.1e-12 46.1 0.0 2.0 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 AMD18580.1 - 0.0026 17.5 0.0 0.0042 16.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Nexin_C PF08628.7 AMD18580.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Sorting nexin C terminal MFS_1 PF07690.11 AMD18581.1 - 1.6e-28 99.4 39.4 2.5e-28 98.8 23.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily N2227 PF07942.7 AMD18582.1 - 4.8e-64 215.9 0.4 6.5e-64 215.5 0.3 1.1 1 0 0 1 1 1 1 N2227-like protein WD40 PF00400.27 AMD18583.1 - 4.9e-36 121.3 5.8 1.1e-06 28.2 0.0 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat NLE PF08154.7 AMD18583.1 - 9.2e-26 89.6 0.1 1.8e-25 88.7 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 AMD18583.1 - 6.3e-10 37.8 4.0 0.00013 20.2 0.6 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Mtc PF03820.12 AMD18584.1 - 8e-123 408.9 0.3 8.9e-123 408.8 0.2 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier GHMP_kinases_N PF00288.21 AMD18585.1 - 3.9e-23 81.2 0.7 1.1e-22 79.8 0.5 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 AMD18585.1 - 1.5e-07 31.4 0.1 5.9e-07 29.5 0.0 2.0 1 1 1 2 2 2 1 GHMP kinases C terminal V_ATPase_I PF01496.14 AMD18586.1 - 1.1e-275 916.3 7.0 1.3e-275 916.1 4.9 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Snapin_Pallidin PF14712.1 AMD18586.1 - 0.047 13.9 0.1 0.047 13.9 0.1 1.9 2 0 0 2 2 2 0 Snapin/Pallidin WD40 PF00400.27 AMD18587.1 - 3.6e-33 112.2 13.0 1.5e-08 34.1 0.6 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 AMD18587.1 - 2.1e-05 22.9 2.7 0.0083 14.3 0.2 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Pkinase PF00069.20 AMD18588.1 - 4.8e-58 196.3 0.0 1.2e-57 195.0 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18588.1 - 6.3e-20 71.3 0.1 3.6e-19 68.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 AMD18588.1 - 0.047 13.4 0.0 0.43 10.2 0.0 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 AMD18588.1 - 0.14 11.1 0.0 0.3 10.0 0.0 1.5 1 1 0 1 1 1 0 Kinase-like DUF223 PF02721.9 AMD18588.1 - 0.17 12.0 2.5 0.2 11.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF223 TBCA PF02970.11 AMD18590.1 - 1.3e-27 95.6 10.0 1.6e-27 95.3 7.0 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A CENP-Q PF13094.1 AMD18590.1 - 0.0027 17.7 2.8 0.0039 17.2 1.9 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Troponin PF00992.15 AMD18590.1 - 0.0039 17.2 5.5 0.005 16.9 3.8 1.3 1 1 0 1 1 1 1 Troponin TcdB_toxin_midC PF12255.3 AMD18590.1 - 0.0091 15.6 0.3 0.013 15.1 0.2 1.2 1 0 0 1 1 1 1 Insecticide toxin TcdB middle/C-terminal region DUF1342 PF07072.6 AMD18590.1 - 0.06 12.9 0.6 0.078 12.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) Cytochrom_C_2 PF01322.15 AMD18590.1 - 0.083 13.4 0.4 0.1 13.1 0.3 1.2 1 0 0 1 1 1 0 Cytochrome C' Cortex-I_coil PF09304.5 AMD18590.1 - 0.12 12.4 6.6 0.31 11.1 4.6 1.7 1 1 0 1 1 1 0 Cortexillin I, coiled coil DUF342 PF03961.8 AMD18590.1 - 0.13 10.6 6.3 0.14 10.5 4.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) AAA_13 PF13166.1 AMD18590.1 - 0.16 10.3 6.9 0.19 10.1 4.8 1.0 1 0 0 1 1 1 0 AAA domain DUF4463 PF14703.1 AMD18590.1 - 1.3 9.5 7.0 0.68 10.4 2.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4463) IncA PF04156.9 AMD18590.1 - 2 8.0 7.7 3.4 7.2 5.3 1.5 1 1 0 1 1 1 0 IncA protein Na_Ca_ex PF01699.19 AMD18592.1 - 1.5e-25 89.3 30.6 1.3e-17 63.7 5.9 4.0 5 1 0 5 5 5 2 Sodium/calcium exchanger protein DUF307 PF03733.8 AMD18592.1 - 1e-12 48.2 5.0 1e-12 48.2 3.4 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF307) Neurensin PF14927.1 AMD18592.1 - 0.0024 17.2 0.2 0.01 15.2 0.0 2.3 2 0 0 2 2 2 1 Neurensin IF4E PF01652.13 AMD18593.1 - 1.6e-55 187.1 0.1 2e-55 186.8 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Abhydrolase_5 PF12695.2 AMD18594.1 - 2.3e-19 69.6 0.0 3.3e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 AMD18594.1 - 3.2e-17 63.1 0.0 3.3e-15 56.5 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD18594.1 - 2.4e-08 33.8 0.1 0.00033 20.2 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 AMD18594.1 - 1.9e-05 23.9 0.0 0.025 13.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family BAAT_C PF08840.6 AMD18594.1 - 0.0043 16.7 0.0 0.92 9.1 0.0 2.2 1 1 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.8 AMD18594.1 - 0.0049 16.3 0.0 0.006 16.0 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF2305 PF10230.4 AMD18594.1 - 0.02 14.3 0.0 3.9 6.8 0.1 2.2 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2305) DUF1749 PF08538.5 AMD18594.1 - 0.034 13.0 0.0 0.12 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.3 AMD18594.1 - 0.054 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase Peptidase_S15 PF02129.13 AMD18594.1 - 0.14 11.5 0.0 0.46 9.8 0.0 1.7 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) WD40 PF00400.27 AMD18595.1 - 5.5e-16 57.7 4.5 9.8e-07 28.4 0.0 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat zf-rbx1 PF12678.2 AMD18595.1 - 1e-05 25.5 3.8 2.5e-05 24.3 2.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 AMD18595.1 - 0.0037 17.0 5.5 0.0037 17.0 3.8 1.9 2 0 0 2 2 2 1 Ring finger domain zf-Apc11 PF12861.2 AMD18595.1 - 0.13 12.0 6.5 0.31 10.9 4.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.6 AMD18595.1 - 1.3 9.0 9.8 0.068 13.1 2.6 2.1 2 1 0 2 2 2 0 RING-like domain zf-C3HC4_2 PF13923.1 AMD18595.1 - 1.4 8.9 11.8 0.096 12.7 3.6 2.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD18595.1 - 2.4 7.9 9.6 0.38 10.4 2.9 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.27 AMD18596.1 - 7.5e-41 136.5 13.4 4.5e-10 39.0 0.3 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 AMD18596.1 - 2.5e-06 27.3 1.7 0.0004 20.1 0.6 3.5 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 AMD18596.1 - 0.07 11.2 0.2 0.2 9.7 0.1 1.8 1 1 0 1 1 1 0 Nucleoporin Nup120/160 6PF2K PF01591.13 AMD18597.1 - 1.7e-51 174.4 1.5 2.7e-51 173.8 1.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.1 AMD18597.1 - 3.8e-05 23.6 0.0 7.1e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD18597.1 - 4.2e-05 24.3 0.0 0.00022 22.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.5 AMD18597.1 - 0.0022 17.2 0.0 0.0036 16.5 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.1 AMD18597.1 - 0.004 17.4 0.0 0.0085 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain Med7 PF05983.6 AMD18598.1 - 1.8e-66 222.8 1.4 2.1e-66 222.7 1.0 1.0 1 0 0 1 1 1 1 MED7 protein ADIP PF11559.3 AMD18598.1 - 0.025 14.4 2.4 0.047 13.6 0.4 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding SNF2_N PF00176.18 AMD18598.1 - 0.046 12.5 0.1 0.058 12.1 0.1 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain DUF3702 PF12486.3 AMD18598.1 - 0.47 10.1 3.2 0.63 9.7 0.3 2.1 2 0 0 2 2 2 0 ImpA domain protein Med4 PF10018.4 AMD18598.1 - 1.2 8.5 5.3 0.37 10.1 1.7 1.6 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 PA28_alpha PF02251.13 AMD18598.1 - 7.6 6.7 6.4 43 4.3 0.1 3.3 3 0 0 3 3 3 0 Proteasome activator pa28 alpha subunit zf-rbx1 PF12678.2 AMD18599.1 - 1.6e-31 108.2 13.9 2e-31 107.9 9.7 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 AMD18599.1 - 7.3e-17 60.9 10.7 9.2e-17 60.6 7.4 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 AMD18599.1 - 4e-07 29.7 12.4 3.2e-06 26.8 8.6 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 AMD18599.1 - 0.0014 18.2 12.0 0.0065 16.1 8.3 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD18599.1 - 0.0095 15.9 2.4 0.0095 15.9 1.7 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 AMD18599.1 - 0.09 12.3 3.0 0.15 11.5 2.1 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.1 AMD18599.1 - 0.17 11.5 10.9 11 5.7 7.6 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.1 AMD18599.1 - 0.34 10.9 9.0 0.96 9.4 6.2 1.8 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 AMD18599.1 - 0.38 10.9 9.4 28 4.9 6.5 2.1 1 1 0 1 1 1 0 PHD-like zinc-binding domain FANCL_C PF11793.3 AMD18599.1 - 1.4 8.9 10.1 6.3 6.8 7.1 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 AMD18599.1 - 1.9 8.4 7.4 1.2 9.0 0.3 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 AMD18599.1 - 2.4 7.9 11.9 16 5.3 8.3 2.2 1 1 0 1 1 1 0 zinc-RING finger domain PDT PF00800.13 AMD18600.1 - 3.7e-52 176.5 0.4 5.1e-52 176.0 0.3 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.20 AMD18600.1 - 0.023 14.1 0.0 0.061 12.8 0.0 1.7 1 0 0 1 1 1 0 ACT domain ATP11 PF06644.6 AMD18601.1 - 3.8e-96 321.6 5.8 4.3e-96 321.4 4.0 1.0 1 0 0 1 1 1 1 ATP11 protein Capsule_synth PF05159.9 AMD18601.1 - 0.012 15.1 0.2 0.027 13.9 0.0 1.6 2 0 0 2 2 2 0 Capsule polysaccharide biosynthesis protein DUF1426 PF07234.6 AMD18601.1 - 0.032 13.9 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1426) DUF655 PF04919.7 AMD18601.1 - 0.063 12.9 0.6 0.12 12.0 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF655) Sds3 PF08598.6 AMD18601.1 - 0.16 11.4 4.7 0.3 10.5 3.0 1.5 1 1 0 1 1 1 0 Sds3-like TPR_11 PF13414.1 AMD18602.1 - 1.6e-14 53.2 2.2 2e-10 40.1 0.1 4.4 3 1 0 3 3 3 1 TPR repeat TPR_14 PF13428.1 AMD18602.1 - 4.1e-09 36.2 0.5 0.19 12.4 0.1 5.9 4 2 2 6 6 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 AMD18602.1 - 7.4e-08 31.9 0.1 0.0011 19.0 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD18602.1 - 1.2e-07 31.0 2.2 0.0086 15.9 0.0 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 AMD18602.1 - 8.3e-07 28.3 1.2 0.35 10.7 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 AMD18602.1 - 2e-06 27.1 0.8 0.17 11.5 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 AMD18602.1 - 3.1e-06 27.0 0.3 0.0016 18.3 0.0 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 AMD18602.1 - 3.2e-06 27.3 0.7 0.064 13.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 AMD18602.1 - 2e-05 25.0 0.0 0.27 11.9 0.0 4.0 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD18602.1 - 0.019 14.7 1.0 3 7.8 0.0 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.4 AMD18602.1 - 0.032 13.6 0.6 0.18 11.1 0.1 2.5 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_15 PF13429.1 AMD18602.1 - 0.052 12.5 0.1 0.31 10.0 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 AMD18602.1 - 0.06 13.2 0.4 1.9 8.3 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF72 PF01904.13 AMD18602.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF72 RPA_C PF08784.6 AMD18603.1 - 9.2e-09 35.6 0.2 4.1e-08 33.5 0.0 2.1 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 AMD18603.1 - 3.3e-07 30.0 0.7 6.5e-07 29.1 0.5 1.5 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain Glyco_hydro_72 PF03198.9 AMD18604.1 - 1.5e-132 441.3 1.9 1.9e-132 441.0 1.3 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 AMD18604.1 - 0.0013 18.0 0.6 0.0062 15.7 0.4 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SpoVG PF04026.7 AMD18604.1 - 0.093 12.7 0.0 2.5 8.1 0.0 2.4 1 1 1 2 2 2 0 SpoVG zf-DNL PF05180.7 AMD18605.1 - 1.1e-31 108.3 1.0 2.2e-31 107.3 0.7 1.5 1 0 0 1 1 1 1 DNL zinc finger Elf1 PF05129.8 AMD18605.1 - 0.011 15.4 1.0 0.02 14.5 0.7 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-CSL PF05207.8 AMD18605.1 - 0.035 13.6 0.2 0.078 12.5 0.1 1.6 1 0 0 1 1 1 0 CSL zinc finger HypA PF01155.14 AMD18605.1 - 0.041 13.5 0.2 0.062 12.9 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zinc_ribbon_4 PF13717.1 AMD18605.1 - 0.051 13.2 0.9 2.9 7.6 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AMD18605.1 - 0.07 12.7 1.1 3.3 7.3 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-H2C2_2 PF13465.1 AMD18605.1 - 0.9 9.9 4.5 1.5 9.2 0.1 2.7 1 1 1 2 2 2 0 Zinc-finger double domain TFIIS_C PF01096.13 AMD18605.1 - 5.6 6.6 6.5 30 4.3 0.5 2.2 1 1 2 3 3 3 0 Transcription factor S-II (TFIIS) CorA PF01544.13 AMD18607.1 - 5.1e-41 140.6 2.1 1.4e-24 86.6 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein DUF4234 PF14018.1 AMD18607.1 - 0.11 12.1 0.5 0.27 10.9 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) Kri1_C PF12936.2 AMD18608.1 - 5.7e-31 106.3 4.9 5.7e-31 106.3 3.4 4.4 4 1 1 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.7 AMD18608.1 - 5.3e-17 61.9 12.1 5.3e-17 61.9 8.4 6.0 3 2 2 5 5 5 1 KRI1-like family UPF0220 PF05255.6 AMD18609.1 - 4.2e-58 195.2 2.1 4.7e-58 195.1 1.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Pkinase PF00069.20 AMD18610.1 - 7.5e-58 195.7 0.0 8.7e-58 195.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18610.1 - 2.1e-29 102.3 0.0 2.8e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD18610.1 - 1.3e-05 24.2 0.0 2.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD18610.1 - 0.0017 18.1 0.0 0.0036 17.0 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 AMD18610.1 - 0.01 14.9 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 AMD18610.1 - 0.039 13.5 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_S11 PF00411.14 AMD18611.1 - 0.0039 17.3 0.1 0.0075 16.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_L23 PF00276.15 AMD18612.1 - 9.8e-21 73.5 1.8 9.8e-21 73.5 1.2 1.9 2 0 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.8 AMD18612.1 - 2.7e-19 68.9 8.6 2.7e-19 68.9 5.9 2.0 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Lipoprotein_1 PF00820.14 AMD18612.1 - 0.027 13.5 0.3 0.038 13.0 0.2 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein zf-DHHC PF01529.15 AMD18613.1 - 0.63 9.4 7.5 0.84 9.0 0.1 2.5 1 1 1 2 2 2 0 DHHC palmitoyltransferase EamA PF00892.15 AMD18613.1 - 0.95 9.5 15.9 4.1 7.4 8.5 3.0 2 1 1 3 3 3 0 EamA-like transporter family DUF4233 PF14017.1 AMD18613.1 - 5.4 6.9 8.2 6.8 6.6 0.5 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF4233) Ldh_1_N PF00056.18 AMD18614.1 - 5e-35 120.3 0.1 9.9e-35 119.4 0.1 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 AMD18614.1 - 1.4e-34 119.3 0.0 2.1e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain HTH_28 PF13518.1 AMD18614.1 - 0.065 13.2 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain CPSase_L_D3 PF02787.14 AMD18614.1 - 0.11 12.2 0.0 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain TRM13 PF05206.9 AMD18615.1 - 8.2e-73 244.8 0.2 1.3e-72 244.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.3 AMD18615.1 - 3.8e-12 45.3 5.5 4.7e-12 45.0 2.7 2.1 1 1 0 1 1 1 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.7 AMD18615.1 - 3.2e-09 36.2 1.7 3.2e-09 36.2 1.1 1.9 2 0 0 2 2 2 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.1 AMD18615.1 - 0.00058 19.5 4.6 0.0023 17.6 1.8 2.5 2 1 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.13 AMD18616.1 - 1.2e-12 47.7 0.0 2.1e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 AMD18616.1 - 7.3e-07 29.2 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.11 AMD18616.1 - 0.036 13.1 0.0 0.056 12.5 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase RRM_1 PF00076.17 AMD18617.1 - 3.6e-37 125.8 0.2 6.9e-19 67.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD18617.1 - 1.2e-33 114.9 0.0 2.5e-16 59.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD18617.1 - 2.3e-12 46.5 0.0 8.2e-06 25.5 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nramp PF01566.13 AMD18618.1 - 8.9e-89 297.7 16.8 8.9e-89 297.7 11.7 1.8 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein Ribosomal_S19e PF01090.14 AMD18619.1 - 5.9e-54 181.2 0.0 7.2e-54 181.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L18e PF00828.14 AMD18620.1 - 1.6e-23 83.4 0.1 1.6e-23 83.4 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L18e/L15 MFS_1 PF07690.11 AMD18621.1 - 1.2e-27 96.5 36.2 1.2e-27 96.5 25.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 AMD18621.1 - 0.00091 17.9 7.5 0.00091 17.9 5.2 3.5 2 2 1 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.2 AMD18621.1 - 0.014 15.1 0.1 0.014 15.1 0.1 2.8 3 0 0 3 3 3 0 MFS_1 like family Redoxin PF08534.5 AMD18622.1 - 1.2e-27 96.1 0.0 1.5e-27 95.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 AMD18622.1 - 8.3e-12 44.8 0.0 1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family GCR1_C PF12550.3 AMD18624.1 - 8.7e-25 86.4 0.1 1.7e-24 85.4 0.1 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DUF2360 PF10152.4 AMD18624.1 - 2.4 8.4 5.8 22 5.3 4.0 2.4 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Yae1_N PF09811.4 AMD18625.1 - 0.02 14.4 7.0 0.048 13.1 4.9 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Kelch_3 PF13415.1 AMD18627.1 - 2.9e-33 113.2 2.5 2.4e-05 24.3 0.1 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 AMD18627.1 - 8.8e-29 98.9 9.0 0.00019 21.2 0.4 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 AMD18627.1 - 3.3e-25 87.5 7.8 0.00017 21.2 0.1 6.6 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 AMD18627.1 - 5.6e-22 76.9 7.9 0.0022 18.1 0.0 6.6 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.20 AMD18627.1 - 9.7e-20 69.8 0.9 2.6e-06 26.8 0.0 5.8 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 AMD18627.1 - 1.7e-12 46.5 7.0 0.12 12.1 0.0 6.9 7 0 0 7 7 7 6 Kelch motif TPR_MLP1_2 PF07926.7 AMD18627.1 - 1.8 8.2 50.6 3.7 7.3 11.2 4.7 2 2 2 4 4 3 0 TPR/MLP1/MLP2-like protein DUF4114 PF13448.1 AMD18630.1 - 0.086 13.6 0.5 0.19 12.5 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4114) ApoO PF09769.4 AMD18631.1 - 6.9e-35 120.0 0.0 1e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 Apolipoprotein O BRCT PF00533.21 AMD18632.1 - 1.1e-29 102.4 4.7 4.2e-06 26.8 0.0 6.3 5 1 0 5 5 5 5 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 AMD18632.1 - 2.2e-20 72.2 1.5 1.5e-14 53.6 0.3 4.9 6 0 0 6 6 6 2 twin BRCT domain Cir_N PF10197.4 AMD18633.1 - 0.051 13.5 2.0 0.051 13.5 1.4 2.8 3 0 0 3 3 3 0 N-terminal domain of CBF1 interacting co-repressor CIR PPP4R2 PF09184.6 AMD18633.1 - 0.43 10.0 10.5 0.51 9.8 7.2 1.1 1 0 0 1 1 1 0 PPP4R2 bZIP_Maf PF03131.12 AMD18633.1 - 0.48 10.7 11.2 0.2 11.9 5.3 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor CWC25 PF12542.3 AMD18633.1 - 1.1 9.7 14.6 0.23 11.9 7.3 2.0 2 1 0 2 2 2 0 Pre-mRNA splicing factor DUF908 PF06012.7 AMD18633.1 - 2.5 7.2 5.9 2.8 7.1 4.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) DDHD PF02862.12 AMD18633.1 - 3.5 7.3 9.9 3.9 7.1 6.8 1.1 1 0 0 1 1 1 0 DDHD domain DUF1168 PF06658.7 AMD18633.1 - 8.8 5.8 21.2 0.62 9.5 10.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) Ank_2 PF12796.2 AMD18635.1 - 1.1e-30 105.8 0.9 1.6e-16 60.4 0.1 3.9 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) SPX PF03105.14 AMD18635.1 - 2.5e-30 106.1 12.8 2.5e-16 60.2 2.9 3.0 2 1 1 3 3 3 2 SPX domain Ank PF00023.25 AMD18635.1 - 4.3e-27 92.5 2.7 1.8e-05 24.3 0.0 6.8 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 AMD18635.1 - 8.7e-23 80.2 4.3 1.3e-09 38.3 0.1 4.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 AMD18635.1 - 1.3e-22 79.2 6.1 3.1e-07 30.4 0.2 5.6 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 AMD18635.1 - 8.5e-21 71.9 4.5 0.0026 17.8 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat GDPD PF03009.12 AMD18635.1 - 0.00077 19.0 0.0 0.0029 17.1 0.0 2.0 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.2 AMD18636.1 - 1.1e-40 137.7 1.4 9.7e-21 73.9 0.1 3.4 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.1 AMD18636.1 - 1.7e-32 108.2 0.1 2.1e-07 30.5 0.0 6.9 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.25 AMD18636.1 - 3.9e-31 105.2 0.0 7.4e-09 34.9 0.0 6.7 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.1 AMD18636.1 - 8.3e-30 102.6 0.1 2.4e-09 37.4 0.0 5.0 3 2 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 AMD18636.1 - 5.7e-27 93.1 0.1 7.3e-08 32.4 0.0 6.0 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Band_7 PF01145.20 AMD18637.1 - 3.6e-22 79.1 0.4 5.2e-22 78.6 0.3 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Methyltransf_5 PF01795.14 AMD18637.1 - 0.031 13.5 1.7 0.051 12.8 1.2 1.2 1 0 0 1 1 1 0 MraW methylase family Spo12 PF05032.7 AMD18638.1 - 5.9e-20 70.6 4.5 5.9e-20 70.6 3.1 2.4 2 0 0 2 2 2 1 Spo12 family LUC7 PF03194.10 AMD18638.1 - 0.036 13.5 1.4 0.52 9.8 0.0 2.0 1 1 1 2 2 2 0 LUC7 N_terminus SMI1_KNR4 PF09346.5 AMD18639.1 - 4.9e-37 126.8 0.0 1.3e-36 125.4 0.0 1.8 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) DIE2_ALG10 PF04922.7 AMD18640.1 - 1.4e-109 366.6 45.7 2e-109 366.1 31.7 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family Lectin_C PF00059.16 AMD18641.1 - 6.8e-05 23.4 1.9 0.0015 19.1 0.2 3.1 3 0 0 3 3 3 1 Lectin C-type domain NAD_kinase PF01513.16 AMD18641.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 ATP-NAD kinase Pex24p PF06398.6 AMD18642.1 - 2.6e-72 243.6 3.8 3.4e-72 243.2 2.7 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF639 PF04842.7 AMD18642.1 - 0.0025 16.0 0.0 0.0035 15.5 0.0 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) 2TM PF13239.1 AMD18642.1 - 0.012 15.6 0.3 0.038 14.0 0.2 1.8 1 0 0 1 1 1 0 2TM domain PRT_C PF08372.5 AMD18642.1 - 0.28 10.6 3.5 1.4 8.3 0.3 2.3 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal WD40 PF00400.27 AMD18643.1 - 1e-13 50.5 9.4 0.00057 19.6 0.0 6.4 8 0 0 8 8 8 3 WD domain, G-beta repeat LuxE PF04443.7 AMD18643.1 - 0.029 13.0 0.0 0.047 12.3 0.0 1.2 1 0 0 1 1 1 0 Acyl-protein synthetase, LuxE WD40 PF00400.27 AMD18644.1 - 0.01 15.7 0.0 0.25 11.2 0.0 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF2414 PF10309.4 AMD18644.1 - 0.059 13.0 0.2 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2414) SKG6 PF08693.5 AMD18646.1 - 0.00029 20.0 6.0 0.00051 19.2 4.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.1 AMD18646.1 - 0.066 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family Ribosomal_S4 PF00163.14 AMD18647.1 - 5.5e-24 84.3 2.3 1.4e-23 83.0 1.7 1.5 2 0 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 AMD18647.1 - 2.7e-11 42.7 0.0 5.3e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain Ribosomal_L6 PF00347.18 AMD18648.1 - 2.1e-21 76.1 0.9 5.5e-10 39.6 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_L3 PF00297.17 AMD18649.1 - 3.2e-42 144.7 4.6 1.9e-41 142.2 3.2 1.9 1 1 0 1 1 1 1 Ribosomal protein L3 CRM1_C PF08767.6 AMD18650.1 - 1.1e-129 431.8 3.2 1.1e-129 431.8 2.2 3.3 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.7 AMD18650.1 - 1.3e-38 132.2 12.1 1.8e-38 131.7 5.1 3.5 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.14 AMD18650.1 - 5.2e-13 48.7 4.2 1.2e-12 47.5 0.0 3.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain DUF507 PF04368.8 AMD18650.1 - 0.0068 16.0 2.3 1.1 8.8 0.1 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF507) DUF357 PF04010.8 AMD18650.1 - 0.016 14.9 0.0 0.26 10.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF357) Ion_trans PF00520.26 AMD18651.1 - 2.2e-81 271.9 98.4 7e-30 103.7 8.5 5.7 5 1 0 5 5 5 4 Ion transport protein EF-hand_1 PF00036.27 AMD18651.1 - 0.0013 17.8 0.0 0.011 14.9 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 AMD18651.1 - 0.012 15.4 0.1 0.065 13.1 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain Gpi1 PF05024.10 AMD18652.1 - 1.1e-49 168.7 19.1 2.8e-49 167.3 13.3 1.7 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) MRP-S33 PF08293.6 AMD18653.1 - 3.5e-30 103.8 0.3 4e-30 103.6 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ribosomal_S2 PF00318.15 AMD18654.1 - 2.1e-38 131.6 0.1 8.7e-20 70.8 0.0 2.3 1 1 1 2 2 2 2 Ribosomal protein S2 AATase PF07247.7 AMD18655.1 - 1.9e-50 171.8 1.6 3.1e-50 171.1 1.1 1.3 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 AMD18655.1 - 2.6e-09 36.3 0.0 4.7e-09 35.5 0.0 1.4 1 1 0 1 1 1 1 Condensation domain zf-ZPR1 PF03367.8 AMD18656.1 - 8.1e-116 382.6 9.3 4e-58 195.1 0.4 2.4 3 0 0 3 3 3 2 ZPR1 zinc-finger domain HypA PF01155.14 AMD18656.1 - 0.0027 17.3 4.5 0.51 10.0 0.6 2.5 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family UPF0547 PF10571.4 AMD18656.1 - 0.0081 15.8 3.8 0.66 9.7 0.4 2.7 2 0 0 2 2 2 2 Uncharacterised protein family UPF0547 Cytochrom_C_2 PF01322.15 AMD18656.1 - 1.3 9.5 4.6 9.3 6.8 0.1 3.2 4 0 0 4 4 4 0 Cytochrome C' Elf1 PF05129.8 AMD18656.1 - 1.7 8.4 7.6 7.8 6.2 0.0 3.4 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.1 AMD18656.1 - 3.9 7.2 6.4 14 5.4 0.1 3.6 3 1 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 AMD18656.1 - 7.3 6.2 14.9 1.5 8.3 0.6 3.9 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_L32p PF01783.18 AMD18656.1 - 7.6 6.7 8.5 0.68 10.1 1.2 2.6 3 0 0 3 3 3 0 Ribosomal L32p protein family MMR_HSR1_C PF08438.5 AMD18657.1 - 8e-30 103.2 0.0 1.9e-29 102.0 0.0 1.7 2 0 0 2 2 2 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 AMD18657.1 - 1.8e-18 66.5 0.0 3.9e-18 65.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD18657.1 - 4.1e-08 32.6 0.1 3.3e-06 26.4 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 AMD18657.1 - 0.00058 19.7 0.4 0.0049 16.6 0.0 2.4 3 0 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.22 AMD18657.1 - 0.00063 19.2 0.1 0.26 10.7 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 AMD18657.1 - 0.0019 17.7 0.3 0.85 9.1 0.0 2.3 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein RHD3 PF05879.7 AMD18657.1 - 0.026 12.4 0.2 1.1 7.1 0.0 2.1 2 0 0 2 2 2 0 Root hair defective 3 GTP-binding protein (RHD3) cobW PF02492.14 AMD18657.1 - 0.033 13.6 0.3 3.4 7.0 0.0 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.17 AMD18657.1 - 0.038 14.1 0.0 13 6.0 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_10 PF12846.2 AMD18657.1 - 0.068 12.6 0.0 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain ArgK PF03308.11 AMD18657.1 - 0.083 11.6 0.8 0.55 8.9 0.0 2.4 2 1 1 3 3 3 0 ArgK protein ABC_tran PF00005.22 AMD18657.1 - 0.097 12.9 0.0 0.33 11.2 0.0 1.8 2 0 0 2 2 2 0 ABC transporter AAA_17 PF13207.1 AMD18657.1 - 0.13 13.0 0.1 0.62 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.5 AMD18657.1 - 0.16 11.1 0.2 0.37 9.9 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AA_permease PF00324.16 AMD18658.1 - 9.3e-112 373.7 44.8 1.1e-111 373.4 31.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD18658.1 - 9.5e-29 100.1 47.8 2.1e-28 99.0 32.9 1.6 1 1 0 1 1 1 1 Amino acid permease TPP_enzyme_M PF00205.17 AMD18659.1 - 6.8e-36 123.0 0.0 3e-35 120.9 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 AMD18659.1 - 1.7e-33 115.5 0.0 2.9e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 AMD18659.1 - 3.9e-14 52.5 0.0 6.5e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.11 AMD18659.1 - 0.078 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit RRM_5 PF13893.1 AMD18660.1 - 6.5e-08 32.3 0.0 1.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD18660.1 - 3.2e-05 23.8 0.0 0.0001 22.2 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD18660.1 - 0.00014 21.3 0.0 0.00029 20.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YozD PF14162.1 AMD18660.1 - 0.1 12.7 0.1 0.42 10.7 0.0 2.0 2 0 0 2 2 2 0 YozD-like protein DUF641 PF04859.7 AMD18661.1 - 2.6e-06 27.2 6.1 7e-06 25.8 4.2 1.7 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) HEAT PF02985.17 AMD18661.1 - 4.4e-06 26.3 0.1 0.35 11.0 0.0 4.7 5 0 0 5 5 3 1 HEAT repeat HEAT_2 PF13646.1 AMD18661.1 - 4.8e-06 26.7 0.0 1.7 8.9 0.0 4.6 2 2 1 3 3 3 2 HEAT repeats TEX13 PF15186.1 AMD18661.1 - 0.00074 19.1 2.7 0.0011 18.5 0.7 2.2 2 0 0 2 2 1 1 Testis-expressed sequence 13 protein family APG6 PF04111.7 AMD18661.1 - 0.00094 18.3 9.6 0.0022 17.0 6.6 1.6 1 0 0 1 1 1 1 Autophagy protein Apg6 Adaptin_N PF01602.15 AMD18661.1 - 0.0015 16.9 0.8 0.057 11.7 0.0 3.1 3 2 1 4 4 4 1 Adaptin N terminal region DUF2454 PF10521.4 AMD18661.1 - 0.0046 16.0 0.0 0.0046 16.0 0.0 2.2 3 0 0 3 3 2 1 Protein of unknown function (DUF2454) Myosin_tail_1 PF01576.14 AMD18661.1 - 0.0057 14.4 10.6 0.011 13.5 7.4 1.3 1 0 0 1 1 1 1 Myosin tail DUF3385 PF11865.3 AMD18661.1 - 0.007 16.3 0.6 1.7 8.5 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3385) Bacillus_HBL PF05791.6 AMD18661.1 - 0.016 14.6 10.1 1.3 8.3 6.0 2.8 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) HEAT_EZ PF13513.1 AMD18661.1 - 0.021 15.3 0.9 5.7 7.5 0.2 3.9 4 0 0 4 4 3 0 HEAT-like repeat HAUS6_N PF14661.1 AMD18661.1 - 0.026 13.9 6.0 0.085 12.1 4.1 1.9 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Tropomyosin_1 PF12718.2 AMD18661.1 - 0.17 11.7 12.5 0.16 11.7 6.8 2.4 2 0 0 2 2 2 0 Tropomyosin like TMF_DNA_bd PF12329.3 AMD18661.1 - 0.23 11.3 15.4 1.7 8.5 6.2 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.3 AMD18661.1 - 0.29 10.3 13.1 0.34 10.1 6.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF342 PF03961.8 AMD18661.1 - 0.61 8.4 3.9 1.3 7.3 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ADIP PF11559.3 AMD18661.1 - 0.66 9.8 18.0 0.051 13.4 8.5 2.2 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.6 AMD18661.1 - 0.84 9.4 22.3 0.15 11.9 11.9 2.3 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Macoilin PF09726.4 AMD18661.1 - 0.85 7.8 18.1 0.17 10.1 10.1 1.5 1 1 0 1 1 1 0 Transmembrane protein Striatin PF08232.7 AMD18661.1 - 0.85 9.9 13.6 0.023 15.0 2.8 3.2 4 0 0 4 4 4 0 Striatin family IncA PF04156.9 AMD18661.1 - 0.91 9.0 10.7 3.4 7.2 7.4 1.9 1 0 0 1 1 1 0 IncA protein Cortex-I_coil PF09304.5 AMD18661.1 - 1.3 9.0 11.6 9.6 6.3 8.0 2.4 1 1 0 1 1 1 0 Cortexillin I, coiled coil Filament PF00038.16 AMD18661.1 - 2.3 7.5 14.0 2.8 7.3 6.5 2.7 2 1 0 2 2 2 0 Intermediate filament protein DUF972 PF06156.8 AMD18661.1 - 2.9 8.2 11.2 3.7 7.9 6.2 2.5 2 0 0 2 2 1 0 Protein of unknown function (DUF972) AAA_23 PF13476.1 AMD18661.1 - 3.6 7.8 8.7 0.15 12.3 1.2 2.3 2 1 0 2 2 2 0 AAA domain DUF4140 PF13600.1 AMD18661.1 - 5.8 7.4 8.3 4.3 7.8 0.6 3.6 2 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Thioredoxin PF00085.15 AMD18662.1 - 2.3e-30 104.3 0.2 2.6e-30 104.1 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 AMD18662.1 - 2.1e-07 31.1 0.3 4.2e-06 26.9 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 AMD18662.1 - 5.5e-06 26.4 0.1 8e-06 25.8 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 AMD18662.1 - 0.00026 20.5 0.0 0.00029 20.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 AMD18662.1 - 0.00092 18.7 0.1 0.0022 17.5 0.0 1.6 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.16 AMD18662.1 - 0.0026 17.4 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.1 AMD18662.1 - 0.041 13.9 0.1 0.067 13.2 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like Phosducin PF02114.11 AMD18662.1 - 0.054 12.2 0.0 0.055 12.1 0.0 1.0 1 0 0 1 1 1 0 Phosducin Hydrolase PF00702.21 AMD18663.1 - 5.9e-14 53.0 0.4 4.1e-13 50.2 0.3 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AMD18663.1 - 6e-13 49.3 0.1 9.5e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AMD18663.1 - 6.7e-08 32.4 2.4 9.2e-07 28.6 0.0 2.8 1 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 AMD18663.1 - 5.7e-05 23.4 0.1 0.002 18.3 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase LUC7 PF03194.10 AMD18663.1 - 0.016 14.7 0.9 0.021 14.3 0.6 1.2 1 0 0 1 1 1 0 LUC7 N_terminus ETF PF01012.16 AMD18664.1 - 2.5e-32 111.8 4.2 4.1e-32 111.1 2.9 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Mvb12 PF09452.5 AMD18665.1 - 3.1e-26 91.3 0.6 3.4e-26 91.2 0.4 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 DUF3584 PF12128.3 AMD18665.1 - 0.07 10.4 0.2 0.082 10.2 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) 3-HAO PF06052.7 AMD18666.1 - 5e-63 211.0 0.1 5.8e-63 210.8 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.6 AMD18666.1 - 2.3e-06 26.9 0.2 4.2e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Nudix_N_2 PF14803.1 AMD18666.1 - 0.0008 19.0 1.0 0.16 11.6 0.3 2.6 2 0 0 2 2 2 2 Nudix N-terminal Cupin_1 PF00190.17 AMD18666.1 - 0.0012 18.3 0.0 0.0021 17.5 0.0 1.4 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.14 AMD18666.1 - 0.025 14.2 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain zf-ribbon_3 PF13248.1 AMD18666.1 - 0.076 12.2 1.6 5.6 6.3 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-B_box PF00643.19 AMD18666.1 - 0.1 12.5 3.9 0.12 12.2 0.5 2.2 2 0 0 2 2 2 0 B-box zinc finger Aldolase_II PF00596.16 AMD18667.1 - 2.8e-42 144.4 0.0 3.3e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain LSM PF01423.17 AMD18668.1 - 1.3e-12 47.0 0.0 2.3e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 LSM domain Mer2 PF09074.5 AMD18669.1 - 8.5e-35 120.4 7.5 5.3e-34 117.8 5.2 1.9 1 1 0 1 1 1 1 Mer2 TelA PF05816.6 AMD18669.1 - 0.00062 18.5 2.3 0.011 14.4 0.2 2.1 2 0 0 2 2 2 2 Toxic anion resistance protein (TelA) IFT57 PF10498.4 AMD18669.1 - 0.026 13.2 8.3 0.018 13.7 2.9 1.9 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Baculo_PEP_C PF04513.7 AMD18669.1 - 0.057 13.2 2.4 0.19 11.5 1.2 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus KxDL PF10241.4 AMD18669.1 - 0.086 12.7 5.2 0.27 11.1 0.6 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein Occludin_ELL PF07303.8 AMD18669.1 - 0.23 12.2 3.1 0.18 12.5 0.3 2.0 2 1 0 2 2 2 0 Occludin homology domain Toxin_52 PF15605.1 AMD18669.1 - 0.99 9.3 5.6 2.9 7.8 0.2 2.9 2 1 1 3 3 3 0 Putative toxin 52 DUF972 PF06156.8 AMD18669.1 - 1.5 9.1 4.4 6.1 7.2 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF972) CENP-F_leu_zip PF10473.4 AMD18669.1 - 3.6 7.4 11.0 0.3 10.9 1.3 2.5 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_16 PF13191.1 AMD18670.1 - 0.00068 19.6 0.0 0.0019 18.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 AMD18670.1 - 0.00094 19.0 0.1 0.005 16.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD18670.1 - 0.0034 18.1 0.0 0.0052 17.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD18670.1 - 0.0045 17.1 0.0 0.23 11.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 AMD18670.1 - 0.0082 15.2 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin RNA_helicase PF00910.17 AMD18670.1 - 0.0093 16.1 0.0 0.022 14.9 0.0 1.6 2 0 0 2 2 2 1 RNA helicase SRP54 PF00448.17 AMD18670.1 - 0.058 12.8 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.1 AMD18670.1 - 0.089 13.0 0.0 0.33 11.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 AMD18670.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain FTHFS PF01268.14 AMD18671.1 - 9.1e-254 842.5 0.3 1.3e-253 842.1 0.2 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 AMD18671.1 - 1.3e-62 209.6 0.3 4e-62 208.0 0.2 1.9 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 AMD18671.1 - 1.3e-37 128.4 0.9 3.1e-37 127.1 0.6 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Rotamase PF00639.16 AMD18672.1 - 9.3e-24 84.0 0.1 1.4e-23 83.4 0.1 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 AMD18672.1 - 3.5e-17 62.7 0.0 4.7e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 AMD18672.1 - 3.6e-10 39.5 0.9 5.8e-10 38.8 0.6 1.3 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.1 AMD18672.1 - 5.4e-08 33.4 0.1 1.4e-07 32.1 0.0 1.6 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rhodanese PF00581.15 AMD18673.1 - 6.3e-12 45.8 0.0 7.2e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain CTP_transf_2 PF01467.21 AMD18674.1 - 1.9e-23 83.2 0.0 3.6e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase ILVD_EDD PF00920.16 AMD18675.1 - 3.1e-205 682.5 0.1 3.5e-205 682.3 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family WD40 PF00400.27 AMD18676.1 - 1.9e-51 170.1 26.0 1.1e-07 31.4 0.0 11.3 12 0 0 12 12 12 9 WD domain, G-beta repeat BBS2_Mid PF14783.1 AMD18676.1 - 5.3e-06 26.1 0.2 0.0026 17.5 0.0 4.9 7 0 0 7 7 7 1 Ciliary BBSome complex subunit 2, middle region PMT PF02366.13 AMD18677.1 - 5e-81 271.6 21.4 5e-81 271.6 14.9 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 AMD18677.1 - 2.8e-12 46.5 0.0 4.1e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 MIR domain Lipase_3 PF01764.20 AMD18678.1 - 4.1e-32 110.7 0.0 5.8e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) zf-DNL PF05180.7 AMD18678.1 - 0.011 15.3 0.5 0.024 14.3 0.3 1.5 1 0 0 1 1 1 0 DNL zinc finger DUF2974 PF11187.3 AMD18678.1 - 0.017 14.5 0.1 5.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.2 AMD18678.1 - 0.052 13.2 0.0 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family PP2C_C PF07830.8 AMD18678.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain Lipase_3 PF01764.20 AMD18679.1 - 3.2e-29 101.3 0.0 5.1e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 AMD18679.1 - 0.086 12.2 0.0 7.2 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) DUF3970 PF13113.1 AMD18679.1 - 0.16 11.6 0.2 0.37 10.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3970) TPR_19 PF14559.1 AMD18680.1 - 0.002 18.4 0.3 0.079 13.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 AMD18680.1 - 0.0021 18.7 0.0 0.28 11.8 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat SUI1 PF01253.17 AMD18681.1 - 5.3e-20 71.0 2.4 6.6e-20 70.7 1.0 1.7 1 1 0 1 1 1 1 Translation initiation factor SUI1 CENP-R PF06729.7 AMD18681.1 - 0.1 12.2 3.8 0.21 11.2 2.6 1.5 1 0 0 1 1 1 0 Kinetochore component, CENP-R HrpA_pilin PF09589.5 AMD18681.1 - 0.12 12.7 0.4 0.22 11.9 0.3 1.4 1 0 0 1 1 1 0 HrpA pilus formation protein DUF947 PF06102.7 AMD18681.1 - 3.6 7.3 12.4 0.037 13.8 3.1 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF947) Calcipressin PF04847.7 AMD18682.1 - 1e-14 54.5 0.5 1.3e-14 54.2 0.4 1.1 1 0 0 1 1 1 1 Calcipressin COX5A PF02284.11 AMD18683.1 - 2.6e-47 159.2 0.8 3.2e-47 158.9 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DUF488 PF04343.8 AMD18683.1 - 0.027 14.8 0.2 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF488 ORC4_C PF14629.1 AMD18683.1 - 0.053 12.9 0.1 0.061 12.6 0.1 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus Elf1 PF05129.8 AMD18684.1 - 4.2e-30 103.2 1.8 5.5e-30 102.9 1.3 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like CDC45 PF02724.9 AMD18684.1 - 0.021 12.8 3.4 0.02 12.9 2.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L37ae PF01780.14 AMD18684.1 - 0.073 12.9 0.9 0.12 12.2 0.6 1.3 1 0 0 1 1 1 0 Ribosomal L37ae protein family zf-C2H2_6 PF13912.1 AMD18684.1 - 0.2 11.6 0.4 0.2 11.6 0.3 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 AMD18684.1 - 0.43 10.7 3.3 7.3 6.7 0.3 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Ribosomal_L1 PF00687.16 AMD18685.1 - 3.1e-44 150.9 2.7 4.4e-44 150.4 1.6 1.4 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Maelstrom PF13017.1 AMD18685.1 - 0.012 15.0 0.5 3 7.2 0.1 2.3 2 0 0 2 2 2 0 piRNA pathway germ-plasm component FlaG PF03646.10 AMD18685.1 - 0.094 12.8 2.6 0.27 11.3 1.8 1.8 1 0 0 1 1 1 0 FlaG protein POTRA_1 PF08478.5 AMD18685.1 - 0.11 12.5 0.1 0.37 10.8 0.0 2.0 1 0 0 1 1 1 0 POTRA domain, FtsQ-type GCR1_C PF12550.3 AMD18686.1 - 2.6e-14 52.8 0.7 4.7e-14 52.0 0.5 1.4 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DUF4588 PF15251.1 AMD18686.1 - 0.012 15.5 1.7 0.021 14.7 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) KIAA1328 PF15369.1 AMD18686.1 - 0.044 13.5 2.1 0.061 13.1 1.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Zip PF02535.17 AMD18686.1 - 0.048 12.6 2.4 0.056 12.4 1.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2946 PF11162.3 AMD18686.1 - 0.08 13.1 3.9 0.12 12.5 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) MatE PF01554.13 AMD18687.1 - 4.6e-62 208.4 39.6 2.4e-34 118.2 8.0 2.6 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.1 AMD18687.1 - 0.0016 18.2 23.5 0.0057 16.4 4.2 4.1 2 2 2 4 4 4 2 Polysaccharide biosynthesis C-terminal domain PIF1 PF05970.9 AMD18688.1 - 8.7e-53 179.5 0.0 6.4e-41 140.4 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 AMD18688.1 - 5e-17 62.1 0.0 1.3e-16 60.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.9 AMD18688.1 - 1.7e-06 26.1 0.4 1.6e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.1 AMD18688.1 - 1.7e-06 28.1 0.0 1.4e-05 25.2 0.0 2.5 3 1 1 4 4 3 1 AAA domain Viral_helicase1 PF01443.13 AMD18688.1 - 3e-05 23.6 0.0 0.01 15.3 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 AMD18688.1 - 0.00048 20.1 0.1 0.0024 17.8 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain FtsK_SpoIIIE PF01580.13 AMD18688.1 - 0.0023 17.4 0.0 0.0043 16.5 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family DUF2075 PF09848.4 AMD18688.1 - 0.0028 16.6 0.0 0.028 13.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.1 AMD18688.1 - 0.0028 17.7 0.0 0.011 15.8 0.0 2.0 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain T2SE PF00437.15 AMD18688.1 - 0.0044 15.9 0.0 0.0086 15.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein TrwB_AAD_bind PF10412.4 AMD18688.1 - 0.0059 15.2 0.0 0.009 14.6 0.0 1.2 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA PF00004.24 AMD18688.1 - 0.016 15.4 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 AMD18688.1 - 0.017 14.8 0.1 0.036 13.8 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain Mg_chelatase PF01078.16 AMD18688.1 - 0.053 12.6 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 AMD18688.1 - 0.059 13.0 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 AMD18688.1 - 0.061 13.0 0.1 0.15 11.7 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 AMD18688.1 - 0.085 13.0 0.0 0.41 10.8 0.0 2.2 2 1 0 2 2 2 0 RNA helicase Helicase_RecD PF05127.9 AMD18688.1 - 0.12 12.0 0.2 0.94 9.0 0.1 2.1 1 1 0 1 1 1 0 Helicase ABC_tran PF00005.22 AMD18688.1 - 0.15 12.3 0.4 0.61 10.3 0.1 2.1 2 0 0 2 2 2 0 ABC transporter Pkinase PF00069.20 AMD18689.1 - 1.7e-66 224.0 0.0 2.1e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18689.1 - 1e-30 106.7 0.0 1.7e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AMD18689.1 - 0.04 13.6 0.1 0.099 12.3 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family SPRY PF00622.23 AMD18690.1 - 0.0073 16.3 0.1 0.033 14.2 0.0 2.2 3 0 0 3 3 3 1 SPRY domain RasGEF PF00617.14 AMD18691.1 - 1.8e-44 151.7 3.4 7.5e-43 146.4 1.2 2.5 2 0 0 2 2 2 2 RasGEF domain RasGEF_N PF00618.15 AMD18691.1 - 5.4e-12 45.7 1.0 1.6e-11 44.2 0.3 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif LDB19 PF13002.2 AMD18692.1 - 6.4e-68 228.0 0.0 9.6e-68 227.4 0.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.24 AMD18692.1 - 0.0006 19.6 0.2 0.0016 18.2 0.0 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain PMT PF02366.13 AMD18693.1 - 7e-90 300.6 15.6 7e-90 300.6 10.8 2.5 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 AMD18693.1 - 4.9e-27 94.6 1.7 7.3e-27 94.1 1.1 1.2 1 0 0 1 1 1 1 MIR domain Nucleoside_tran PF01733.13 AMD18694.1 - 2.1e-26 92.8 14.2 8.7e-26 90.7 9.8 2.0 1 1 0 1 1 1 1 Nucleoside transporter XPG_N PF00752.12 AMD18695.1 - 9.4e-36 122.1 0.0 2.1e-35 121.0 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 AMD18695.1 - 5.1e-27 93.7 0.0 1.3e-26 92.4 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 AMD18695.1 - 4e-05 23.7 0.0 4e-05 23.7 0.0 2.3 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold AP_endonuc_2 PF01261.19 AMD18697.1 - 3.9e-30 104.7 0.0 6e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Pkinase PF00069.20 AMD18698.1 - 2.6e-49 167.6 0.0 3.6e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18698.1 - 3.5e-20 72.1 0.0 1.8e-19 69.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Aldose_epim PF01263.15 AMD18699.1 - 9.4e-47 159.5 0.3 1.1e-46 159.3 0.2 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase CS PF04969.11 AMD18700.1 - 0.0092 16.5 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 CS domain Sporozoite_P67 PF05642.6 AMD18700.1 - 0.083 10.7 2.3 0.1 10.4 1.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-RING_2 PF13639.1 AMD18701.1 - 1.9e-07 30.8 9.4 3.8e-07 29.8 6.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 AMD18701.1 - 7.7e-07 29.1 4.5 1.7e-06 27.9 3.1 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 AMD18701.1 - 1.3e-05 25.0 5.5 3.1e-05 23.8 3.8 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-Apc11 PF12861.2 AMD18701.1 - 0.0015 18.2 2.6 0.0034 17.1 1.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.2 AMD18701.1 - 0.03 14.3 8.7 0.058 13.4 6.0 1.5 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_2 PF13923.1 AMD18701.1 - 0.66 10.0 11.4 2.1 8.4 7.9 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD18701.1 - 0.7 9.5 12.1 1 9.1 7.6 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD18701.1 - 4.1 7.1 7.3 15 5.3 5.0 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Glyco_transf_8 PF01501.15 AMD18702.1 - 1.7e-09 37.3 5.2 1.9e-08 33.9 2.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 AMD18702.1 - 0.0015 17.9 0.7 0.0036 16.6 0.4 1.7 1 1 0 1 1 1 1 Mannosyltransferase putative 3HCDH_N PF02737.13 AMD18702.1 - 0.0021 17.7 0.1 0.016 14.8 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RRM_1 PF00076.17 AMD18703.1 - 8.4e-28 95.8 0.5 5e-15 54.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD18703.1 - 7.9e-17 61.0 0.0 8.9e-10 38.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD18703.1 - 5.1e-13 48.6 1.7 3.6e-09 36.3 0.1 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAM_decarbox PF01536.11 AMD18704.1 - 2e-105 352.1 3.3 2.3e-105 351.9 2.3 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Recep_L_domain PF01030.19 AMD18706.1 - 2.1e-09 37.3 9.7 0.00073 19.4 0.3 4.9 1 1 3 4 4 4 4 Receptor L domain LRR_9 PF14580.1 AMD18706.1 - 0.071 12.6 1.5 0.082 12.4 0.2 1.8 2 0 0 2 2 2 0 Leucine-rich repeat LRR_5 PF13306.1 AMD18706.1 - 0.081 12.6 2.7 0.34 10.6 0.4 2.6 2 2 0 2 2 2 0 Leucine rich repeats (6 copies) Secretin_N_2 PF07655.8 AMD18706.1 - 0.57 10.5 13.6 0.56 10.6 5.9 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain Ecm33 PF12454.3 AMD18706.1 - 3 7.7 9.0 0.62 9.9 2.3 2.8 2 1 0 2 2 2 0 GPI-anchored cell wall organization protein LRR_8 PF13855.1 AMD18706.1 - 4.6 7.0 12.6 0.67 9.7 0.2 4.2 4 1 0 4 4 4 0 Leucine rich repeat GLTP PF08718.6 AMD18707.1 - 4.7e-38 130.5 0.0 1.2e-37 129.2 0.0 1.6 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) DUF92 PF01940.11 AMD18707.1 - 0.095 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 PCI PF01399.22 AMD18708.1 - 1.4e-05 25.3 0.3 0.00024 21.3 0.0 2.8 2 0 0 2 2 2 1 PCI domain DUF2064 PF09837.4 AMD18708.1 - 0.011 15.3 0.0 0.029 13.9 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) AAA PF00004.24 AMD18709.1 - 9.4e-52 174.6 0.0 1.2e-38 132.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.12 AMD18709.1 - 7.6e-12 44.6 4.2 1.8e-11 43.4 0.5 2.9 3 0 0 3 3 3 1 Cell division protein 48 (CDC48), domain 2 CDC48_N PF02359.13 AMD18709.1 - 1.7e-11 43.9 0.0 1.2e-10 41.2 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_22 PF13401.1 AMD18709.1 - 3.6e-09 36.8 1.0 0.0011 19.1 0.2 3.5 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AMD18709.1 - 6.1e-09 35.5 0.5 0.0034 17.0 0.1 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA_16 PF13191.1 AMD18709.1 - 1.5e-08 34.8 0.0 0.0041 17.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 AMD18709.1 - 4.6e-08 33.8 0.0 0.018 15.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 AMD18709.1 - 1.2e-07 30.8 0.3 0.0063 15.2 0.0 2.4 2 1 0 2 2 2 2 TIP49 C-terminus Mg_chelatase PF01078.16 AMD18709.1 - 1.5e-06 27.5 0.2 0.0016 17.6 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 AMD18709.1 - 2.3e-06 27.1 0.3 0.05 13.0 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein NACHT PF05729.7 AMD18709.1 - 5e-06 26.2 1.9 0.033 13.8 0.0 3.7 4 0 0 4 4 4 1 NACHT domain AAA_5 PF07728.9 AMD18709.1 - 5.2e-06 26.2 0.0 0.0021 17.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 AMD18709.1 - 8.7e-06 24.9 0.1 0.069 12.1 0.1 2.9 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 AMD18709.1 - 9.3e-06 25.5 0.0 0.061 13.2 0.0 2.9 3 0 0 3 3 2 2 AAA domain PhoH PF02562.11 AMD18709.1 - 1.1e-05 24.7 0.0 0.017 14.3 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_33 PF13671.1 AMD18709.1 - 1.4e-05 24.9 0.0 0.18 11.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 AMD18709.1 - 1.9e-05 24.9 0.0 0.022 15.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_2 PF07724.9 AMD18709.1 - 2.9e-05 24.0 0.0 0.0015 18.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.17 AMD18709.1 - 5.3e-05 23.3 0.0 0.098 12.8 0.0 3.1 2 0 0 2 2 2 1 RNA helicase DUF2075 PF09848.4 AMD18709.1 - 8.5e-05 21.6 0.0 0.093 11.6 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.22 AMD18709.1 - 9.4e-05 22.7 0.5 0.025 14.8 0.0 2.6 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.1 AMD18709.1 - 0.00031 20.4 2.0 0.45 10.0 0.3 2.7 2 1 0 2 2 2 2 AAA domain NB-ARC PF00931.17 AMD18709.1 - 0.00031 19.7 0.0 0.28 9.9 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.21 AMD18709.1 - 0.00032 20.2 0.0 0.82 9.1 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain DEAD PF00270.24 AMD18709.1 - 0.0014 18.1 0.3 15 5.0 0.1 4.1 2 2 1 4 4 4 0 DEAD/DEAH box helicase Sigma54_activ_2 PF14532.1 AMD18709.1 - 0.0016 18.5 0.3 2.5 8.1 0.1 3.3 2 1 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 AMD18709.1 - 0.0022 17.1 0.0 1.3 8.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.1 AMD18709.1 - 0.0024 17.4 0.0 2.1 7.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 AMD18709.1 - 0.0053 15.8 0.7 0.26 10.3 0.1 2.8 3 0 0 3 3 3 1 KaiC Arch_ATPase PF01637.13 AMD18709.1 - 0.0058 16.3 0.6 7.6 6.1 0.0 3.3 2 1 1 3 3 3 0 Archaeal ATPase AAA_23 PF13476.1 AMD18709.1 - 0.0059 16.9 2.5 2.7 8.2 0.6 2.7 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.12 AMD18709.1 - 0.0064 15.4 0.0 2.5 6.8 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 ResIII PF04851.10 AMD18709.1 - 0.0066 16.2 0.0 3.4 7.4 0.0 2.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_25 PF13481.1 AMD18709.1 - 0.009 15.4 6.4 2.1 7.7 0.3 3.7 2 2 1 4 4 4 2 AAA domain UPF0079 PF02367.12 AMD18709.1 - 0.011 15.4 0.1 2.6 7.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 AMD18709.1 - 0.012 14.5 0.0 1.9 7.2 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Bac_DnaA PF00308.13 AMD18709.1 - 0.012 15.2 0.2 8.8 5.9 0.0 3.4 3 1 0 3 3 3 0 Bacterial dnaA protein AAA_28 PF13521.1 AMD18709.1 - 0.016 15.2 0.0 4 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.6 AMD18709.1 - 0.026 14.1 0.0 0.19 11.3 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 AMD18709.1 - 0.033 13.7 0.1 2.2 7.8 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_10 PF12846.2 AMD18709.1 - 0.035 13.5 0.1 0.79 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain IPT PF01745.11 AMD18709.1 - 0.051 12.7 0.2 0.4 9.8 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase AAA_29 PF13555.1 AMD18709.1 - 0.069 12.6 0.8 1.7 8.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Vps4_C PF09336.5 AMD18709.1 - 0.13 12.1 0.0 0.43 10.5 0.0 1.8 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain NifT PF06988.6 AMD18711.1 - 0.11 12.0 0.0 0.28 10.6 0.0 1.7 1 0 0 1 1 1 0 NifT/FixU protein Bromodomain PF00439.20 AMD18712.1 - 8e-19 67.3 1.2 8e-19 67.3 0.9 2.4 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.8 AMD18712.1 - 3.2e-06 26.7 0.0 4.5e-05 23.1 0.0 2.7 3 0 0 3 3 3 1 Bromodomain associated UQ_con PF00179.21 AMD18713.1 - 2.5e-51 172.8 0.0 2.8e-51 172.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 AMD18713.1 - 5.3e-05 22.9 0.0 6.4e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 AMD18713.1 - 0.00024 20.9 0.0 0.00027 20.8 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 AMD18713.1 - 0.0094 15.6 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 UEV domain CBF PF03914.12 AMD18714.1 - 4.8e-43 146.4 0.7 4.8e-43 146.4 0.5 2.7 3 0 0 3 3 3 1 CBF/Mak21 family TEA PF01285.13 AMD18715.1 - 8.5e-35 120.7 1.0 8.5e-35 120.7 0.7 2.9 1 1 0 2 2 2 1 TEA/ATTS domain family FTHFS PF01268.14 AMD18716.1 - 2.2e-256 851.2 2.8 2.8e-256 850.8 1.9 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 AMD18716.1 - 6.9e-67 223.5 1.4 6.9e-67 223.5 0.9 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 AMD18716.1 - 1.9e-35 121.4 0.3 4.6e-35 120.1 0.2 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Rota_VP2 PF05087.7 AMD18716.1 - 0.22 9.4 0.0 0.51 8.1 0.0 1.4 1 1 0 1 1 1 0 Rotavirus VP2 protein Ribosomal_L19e PF01280.15 AMD18717.1 - 2.4e-56 189.6 12.5 2.4e-56 189.6 8.7 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e DUF2423 PF10338.4 AMD18718.1 - 8.9e-19 67.1 7.5 8.9e-19 67.1 5.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) DUF4632 PF15451.1 AMD18718.1 - 0.013 15.4 0.9 0.019 14.8 0.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4632) Corona_nucleoca PF00937.13 AMD18719.1 - 0.19 10.6 5.8 0.29 10.0 4.0 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Cys_rich_CPCC PF14206.1 AMD18720.1 - 0.83 9.2 4.4 0.77 9.3 0.7 2.0 2 0 0 2 2 2 0 Cysteine-rich CPCC Zn_Tnp_IS1595 PF12760.2 AMD18720.1 - 1.3 8.9 5.6 3.9 7.3 0.1 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Fungal_trans PF04082.13 AMD18721.1 - 2.3e-17 62.7 0.6 4.4e-17 61.8 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD18721.1 - 5.6e-09 35.7 14.0 9.8e-09 34.9 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.22 AMD18722.1 - 1.8e-65 216.6 6.4 2.7e-22 78.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein KH_1 PF00013.24 AMD18724.1 - 2e-32 110.5 7.3 3.3e-12 45.8 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 AMD18724.1 - 1.4e-24 85.1 9.7 2.4e-07 30.2 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 AMD18724.1 - 6e-09 35.3 2.3 0.027 14.0 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 AMD18724.1 - 0.045 13.3 2.6 1.2 8.8 0.0 3.4 3 1 1 4 4 4 0 KH domain KH_5 PF13184.1 AMD18724.1 - 0.058 13.2 1.7 4.1 7.2 0.0 3.0 3 0 0 3 3 3 0 NusA-like KH domain GTP_cyclohydro2 PF00925.15 AMD18725.1 - 8.5e-56 187.8 0.0 3.8e-51 172.6 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II CLASP_N PF12348.3 AMD18727.1 - 8.7e-71 237.8 10.4 1.1e-66 224.4 2.2 2.6 2 0 0 2 2 2 2 CLASP N terminal Pol_alpha_B_N PF08418.5 AMD18728.1 - 3.9e-62 210.0 0.6 5.5e-62 209.5 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 AMD18728.1 - 5.1e-45 153.3 0.6 7.7e-45 152.7 0.4 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B PRESAN PF09687.5 AMD18728.1 - 0.048 13.7 0.7 0.12 12.4 0.5 1.6 1 0 0 1 1 1 0 Plasmodium RESA N-terminal Alg14 PF08660.6 AMD18728.1 - 0.093 12.7 0.1 3.2 7.7 0.0 2.6 2 0 0 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like Anoctamin PF04547.7 AMD18729.1 - 1.5e-47 162.3 20.6 1.2e-41 142.8 4.6 2.2 1 1 0 2 2 2 2 Calcium-activated chloride channel DUF4131 PF13567.1 AMD18729.1 - 2.9 7.2 9.3 0.22 10.9 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Ala_racemase_N PF01168.15 AMD18730.1 - 7.2e-41 140.1 0.1 8.8e-41 139.8 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain OsmC PF02566.14 AMD18730.1 - 0.073 13.2 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 OsmC-like protein Adaptin_N PF01602.15 AMD18731.1 - 2.5e-66 224.1 12.7 3.2e-66 223.7 8.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 AMD18731.1 - 2.7e-06 27.6 0.3 6.9e-06 26.3 0.2 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain RIX1 PF08167.7 AMD18731.1 - 0.00031 20.4 2.0 0.12 11.9 0.0 3.2 3 0 0 3 3 3 2 rRNA processing/ribosome biogenesis Alpha_adaptin_C PF02296.11 AMD18731.1 - 0.005 16.7 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Rep_fac_C PF08542.6 AMD18732.1 - 2e-19 69.3 0.8 3.7e-19 68.4 0.1 1.8 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 AMD18732.1 - 7.3e-13 48.4 0.2 2.2e-12 46.9 0.1 1.8 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 AMD18732.1 - 6.7e-05 23.0 0.4 0.00016 21.8 0.3 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 AMD18732.1 - 0.013 15.5 0.2 0.44 10.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain RuvB_N PF05496.7 AMD18732.1 - 0.035 13.1 0.1 0.86 8.5 0.0 2.5 2 1 1 3 3 3 0 Holliday junction DNA helicase ruvB N-terminus FtsK_SpoIIIE PF01580.13 AMD18732.1 - 0.11 11.9 0.1 1 8.8 0.1 2.5 1 1 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 AMD18732.1 - 0.22 11.6 2.0 0.52 10.4 0.3 2.3 2 1 0 2 2 2 0 AAA domain AAA_10 PF12846.2 AMD18732.1 - 0.29 10.5 1.4 1.2 8.5 0.1 2.0 1 1 0 2 2 2 0 AAA-like domain Ribosomal_L16 PF00252.13 AMD18733.1 - 1.1e-35 122.2 0.5 1.5e-35 121.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA-synt_2d PF01409.15 AMD18734.1 - 3.5e-45 154.1 0.2 6.2e-26 91.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 AMD18734.1 - 2.4e-26 91.7 0.1 7.5e-26 90.1 0.1 1.9 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Phage_connector PF05352.7 AMD18734.1 - 0.011 15.0 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 Phage Connector (GP10) DUF3811 PF11656.3 AMD18734.1 - 0.061 13.3 0.1 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 YjbD family (DUF3811) tRNA-synt_2 PF00152.15 AMD18734.1 - 6.3 5.4 8.5 1 8.0 0.1 3.0 3 1 0 3 3 3 0 tRNA synthetases class II (D, K and N) FAD_binding_1 PF00667.15 AMD18735.1 - 4.4e-28 98.2 0.0 7.6e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 AMD18735.1 - 9.7e-19 67.7 0.0 2.9e-18 66.2 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 AMD18735.1 - 2e-15 57.3 0.0 4.7e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain ATG11 PF10377.4 AMD18736.1 - 8e-38 129.2 0.0 3.2e-37 127.2 0.0 2.1 1 0 0 1 1 1 1 Autophagy-related protein 11 Acetyltransf_1 PF00583.19 AMD18737.1 - 7.7e-18 64.3 0.0 1e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AMD18737.1 - 1.8e-08 34.3 0.0 2.8e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 AMD18737.1 - 2.2e-08 34.1 0.0 2.7e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 AMD18737.1 - 6.5e-08 32.2 0.1 1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 AMD18737.1 - 4.4e-07 30.0 0.0 6.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 AMD18737.1 - 8.7e-05 22.7 0.0 9.9e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AMD18737.1 - 0.0024 17.7 0.0 0.0041 16.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 AMD18737.1 - 0.04 13.7 0.0 0.066 13.1 0.0 1.5 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase PCNA_N PF00705.13 AMD18738.1 - 4.4e-49 165.1 1.9 8.5e-49 164.2 0.7 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 AMD18738.1 - 6e-47 158.7 0.3 6.3e-46 155.4 0.1 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.11 AMD18738.1 - 2.4e-08 33.0 0.5 9e-07 27.9 0.3 2.1 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.8 AMD18738.1 - 5.1e-05 22.5 0.0 6e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Rad9 FOP_dimer PF09398.5 AMD18738.1 - 0.077 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 FOP N terminal dimerisation domain HMG_box PF00505.14 AMD18739.1 - 2.2e-26 91.8 1.9 2.2e-26 91.8 1.3 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 AMD18739.1 - 4.5e-20 71.7 2.3 4.5e-20 71.7 1.6 1.5 2 0 0 2 2 2 1 HMG-box domain HMG_box_5 PF14887.1 AMD18739.1 - 0.0017 18.1 1.3 0.0017 18.1 0.9 2.0 2 1 0 2 2 2 1 HMG (high mobility group) box 5 DUF1014 PF06244.7 AMD18739.1 - 0.022 14.9 0.8 0.059 13.5 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1014) YABBY PF04690.8 AMD18739.1 - 0.025 14.8 0.5 0.034 14.3 0.3 1.3 1 1 0 1 1 1 0 YABBY protein CHDNT PF08073.7 AMD18739.1 - 0.088 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain zf-Tim10_DDP PF02953.10 AMD18740.1 - 3.4e-16 58.2 0.5 5.4e-16 57.6 0.1 1.5 2 0 0 2 2 2 1 Tim10/DDP family zinc finger TTL PF03133.10 AMD18741.1 - 3.8e-73 245.9 4.1 6e-73 245.3 2.8 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.12 AMD18741.1 - 5.3e-14 51.9 0.0 1.3e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.1 AMD18741.1 - 1.2e-06 27.4 0.0 0.014 14.2 0.0 2.2 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 AMD18741.1 - 0.00089 19.0 0.0 0.0044 16.7 0.0 2.1 2 1 0 2 2 2 1 ATP-grasp domain RXT2_N PF08595.6 AMD18742.1 - 2.4e-42 144.2 1.0 2.4e-42 144.2 0.7 2.9 4 0 0 4 4 4 1 RXT2-like, N-terminal Phlebovirus_NSM PF07246.6 AMD18742.1 - 0.0011 18.1 0.5 0.0021 17.2 0.3 1.4 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M Upf2 PF04050.9 AMD18742.1 - 2.4 7.9 12.5 0.086 12.6 3.2 2.5 2 0 0 2 2 2 0 Up-frameshift suppressor 2 4HBT_2 PF13279.1 AMD18743.1 - 9.3e-09 35.7 0.1 1.3e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Pkinase PF00069.20 AMD18744.1 - 2.8e-64 216.7 0.0 3.6e-64 216.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18744.1 - 3.8e-30 104.8 0.0 5.2e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD18744.1 - 0.1 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.20 AMD18745.1 - 3.1e-29 101.9 0.0 8.1e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.17 AMD18745.1 - 9.9e-14 50.1 3.2 0.1 12.7 0.0 6.0 5 0 0 5 5 5 4 HEAT repeat Pkinase_Tyr PF07714.12 AMD18745.1 - 7.3e-11 41.6 0.0 1.6e-10 40.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.1 AMD18745.1 - 2e-09 37.5 0.1 0.0029 17.8 0.0 3.4 2 1 2 4 4 4 4 HEAT repeats HEAT_EZ PF13513.1 AMD18745.1 - 0.0014 19.0 0.0 27 5.4 0.0 4.3 3 1 1 4 4 4 0 HEAT-like repeat Kinase-like PF14531.1 AMD18745.1 - 0.0016 17.4 0.0 0.0033 16.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like WD40 PF00400.27 AMD18745.1 - 0.002 17.9 8.1 6.4 6.8 0.0 5.9 7 0 0 7 7 7 2 WD domain, G-beta repeat APH PF01636.18 AMD18745.1 - 0.032 13.9 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2435 PF10363.4 AMD18745.1 - 0.23 11.3 2.8 2.3 8.1 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2435) Sec8_exocyst PF04048.9 AMD18746.1 - 9.2e-47 158.2 6.1 2.6e-45 153.5 2.0 3.1 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain DUF2451 PF10474.4 AMD18746.1 - 1.4e-09 38.0 2.2 2.3e-07 30.8 0.2 2.9 2 0 0 2 2 2 2 Protein of unknown function C-terminus (DUF2451) Sec5 PF15469.1 AMD18746.1 - 6.4e-05 22.7 4.9 6.4e-05 22.7 3.4 4.1 4 0 0 4 4 4 1 Exocyst complex component Sec5 DUF2450 PF10475.4 AMD18746.1 - 8.3e-05 21.6 4.1 0.00011 21.2 1.2 2.5 2 1 0 2 2 2 1 Protein of unknown function N-terminal domain (DUF2450) Apolipoprotein PF01442.13 AMD18746.1 - 0.0083 15.6 0.5 1.2 8.5 0.0 3.9 3 2 0 3 3 3 1 Apolipoprotein A1/A4/E domain COG2 PF06148.6 AMD18746.1 - 0.22 11.3 10.0 0.024 14.5 0.7 3.9 5 0 0 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 ERCC4 PF02732.10 AMD18747.1 - 7.8e-07 28.9 0.2 1.8e-06 27.7 0.2 1.6 1 0 0 1 1 1 1 ERCC4 domain Fes1 PF08609.5 AMD18748.1 - 4.1e-27 94.5 3.9 4.1e-27 94.5 0.4 2.4 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 AMD18748.1 - 0.00074 19.7 0.0 0.007 16.6 0.0 2.6 2 1 1 3 3 3 1 HEAT repeats CDC14 PF08045.6 AMD18748.1 - 0.0011 18.1 2.9 0.0014 17.8 0.1 2.3 1 1 0 3 3 3 1 Cell division control protein 14, SIN component CTK3 PF12243.3 AMD18748.1 - 0.002 17.7 1.5 0.24 11.0 0.0 2.2 1 1 1 2 2 2 2 CTD kinase subunit gamma CTK3 FPL PF09758.4 AMD18748.1 - 0.044 13.5 5.5 5.1 6.8 0.0 3.2 2 1 0 3 3 3 0 Uncharacterised conserved protein DUF2435 PF10363.4 AMD18748.1 - 0.061 13.2 0.2 0.81 9.6 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2435) HEAT_EZ PF13513.1 AMD18748.1 - 0.11 12.9 0.0 0.59 10.7 0.0 2.4 1 0 0 1 1 1 0 HEAT-like repeat Rad33 PF08730.5 AMD18748.1 - 0.13 11.7 5.8 0.032 13.7 1.5 1.8 2 0 0 2 2 2 0 Rad33 UFD1 PF03152.9 AMD18749.1 - 0.00031 19.9 0.1 0.25 10.4 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 Vps51 PF08700.6 AMD18750.1 - 7.3e-09 35.3 2.7 7.3e-09 35.3 1.9 2.4 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.6 AMD18750.1 - 0.0032 17.3 1.8 0.0032 17.3 1.3 3.0 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF1828 PF08861.5 AMD18750.1 - 0.056 13.0 0.1 0.62 9.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF1828 WD40 PF00400.27 AMD18751.1 - 4e-29 99.4 5.9 8.1e-06 25.5 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat LisH PF08513.6 AMD18751.1 - 1.5e-08 34.1 0.3 3e-08 33.1 0.2 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.6 AMD18751.1 - 9.7e-07 28.6 3.0 3.4e-05 23.6 0.1 3.7 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A DUF3312 PF11768.3 AMD18751.1 - 0.00038 18.8 0.1 0.29 9.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3312) Apc4_WD40 PF12894.2 AMD18751.1 - 0.028 13.8 0.2 9.7 5.7 0.0 4.5 6 0 0 6 6 6 0 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.7 AMD18751.1 - 0.066 11.0 0.3 0.54 8.0 0.0 2.1 2 0 0 2 2 2 0 IKI3 family Tfb4 PF03850.9 AMD18752.1 - 1.2e-103 346.2 0.0 1.3e-103 346.0 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 VWA_2 PF13519.1 AMD18752.1 - 0.00081 19.5 0.0 0.0011 19.1 0.0 1.3 1 1 0 1 1 1 1 von Willebrand factor type A domain Ku_N PF03731.10 AMD18752.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.4 1 1 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain Put_Phosphatase PF06888.7 AMD18753.1 - 0.023 13.8 0.2 0.026 13.6 0.1 1.2 1 0 0 1 1 1 0 Putative Phosphatase Gin PF10764.4 AMD18753.1 - 0.043 13.5 0.3 10 5.9 0.0 2.5 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin zf-C2H2 PF00096.21 AMD18753.1 - 0.6 10.5 6.0 6.5 7.3 0.0 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD18753.1 - 1.4 9.4 9.5 13 6.4 2.1 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AMD18753.1 - 1.6 8.9 4.7 5.5 7.2 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding SIP1 PF04938.7 AMD18754.1 - 0.00088 18.6 0.3 0.012 14.9 0.1 2.2 2 0 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) PB1-F2 PF11986.3 AMD18754.1 - 0.055 13.4 0.1 0.1 12.6 0.1 1.5 1 0 0 1 1 1 0 Influenza A Proapoptotic protein CM_2 PF01817.16 AMD18755.1 - 6.3e-09 35.8 0.2 0.0013 18.7 0.0 3.3 2 1 0 2 2 2 2 Chorismate mutase type II DnaJ PF00226.26 AMD18756.1 - 1.5e-16 59.9 1.4 1.6e-16 59.7 0.2 1.7 2 0 0 2 2 2 1 DnaJ domain DUF4248 PF14053.1 AMD18756.1 - 0.064 12.8 0.6 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) Vac_ImportDeg PF09783.4 AMD18758.1 - 9.7e-68 227.1 1.1 1.3e-67 226.7 0.8 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein HMG_box PF00505.14 AMD18759.1 - 1.3e-13 50.9 6.8 1.3e-13 50.9 4.7 2.4 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 AMD18759.1 - 4.9e-09 36.4 1.1 4.9e-09 36.4 0.8 2.1 2 0 0 2 2 2 1 HMG-box domain DUF4145 PF13643.1 AMD18759.1 - 0.047 13.5 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) Pho88 PF10032.4 AMD18760.1 - 3.4e-78 261.2 1.0 3.8e-78 261.1 0.7 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) ThiF PF00899.16 AMD18761.1 - 6.7e-30 103.6 0.0 1.5e-29 102.5 0.0 1.6 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 AMD18761.1 - 2.8e-15 55.6 0.0 4.5e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 AMD18761.1 - 2e-08 33.5 0.7 3.6e-08 32.6 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 AMD18761.1 - 0.0043 17.1 0.0 0.0082 16.2 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase MoeZ_MoeB PF05237.8 AMD18761.1 - 0.091 12.3 1.6 0.19 11.3 0.0 2.2 2 0 0 2 2 2 0 MoeZ/MoeB domain Fe-S_biosyn PF01521.15 AMD18762.1 - 5.6e-13 48.8 0.2 2.6e-11 43.4 0.1 2.1 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis YqzH PF14164.1 AMD18762.1 - 0.0014 18.4 0.2 0.0027 17.5 0.1 1.4 1 0 0 1 1 1 1 YqzH-like protein EF-hand_1 PF00036.27 AMD18765.1 - 5.9e-29 97.1 3.9 1.7e-08 33.1 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 AMD18765.1 - 2.3e-26 91.6 0.4 2.2e-12 46.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 AMD18765.1 - 1.3e-24 83.7 3.1 3.6e-08 32.6 0.0 4.3 3 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 AMD18765.1 - 3.5e-18 64.9 5.1 1.6e-05 24.4 0.0 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 AMD18765.1 - 3e-16 57.9 3.5 1.9e-07 30.1 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.1 AMD18765.1 - 3.6e-10 39.6 0.0 1.1e-06 28.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.8 AMD18765.1 - 1e-06 28.2 0.0 0.086 12.4 0.0 3.0 3 1 1 4 4 4 2 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.4 AMD18765.1 - 6.4e-05 22.9 0.0 0.022 14.7 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.8 AMD18765.1 - 0.0054 16.2 0.0 1.7 8.1 0.0 2.2 2 0 0 2 2 2 2 Caleosin related protein EF-hand_4 PF12763.2 AMD18765.1 - 0.0071 16.0 0.1 0.019 14.7 0.0 1.7 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF853 PF05872.7 AMD18765.1 - 0.014 13.7 0.1 0.05 11.9 0.1 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) RNA_pol_Rpb4 PF03874.11 AMD18765.1 - 0.08 12.9 0.2 0.88 9.5 0.0 2.3 2 1 0 2 2 2 0 RNA polymerase Rpb4 TerB PF05099.8 AMD18765.1 - 0.091 12.4 0.1 3 7.5 0.0 2.4 2 1 1 3 3 3 0 Tellurite resistance protein TerB Glyco_trans_1_4 PF13692.1 AMD18766.1 - 5.9e-16 58.8 0.0 2e-15 57.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 AMD18766.1 - 3e-11 43.0 0.0 4.7e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 AMD18766.1 - 2.4e-05 24.5 0.0 3.7e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.1 AMD18766.1 - 0.018 15.2 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 Hist_deacetyl PF00850.14 AMD18767.1 - 1.4e-69 234.8 0.0 2.3e-69 234.0 0.0 1.3 1 1 0 1 1 1 1 Histone deacetylase domain Spermine_synth PF01564.12 AMD18768.1 - 2.4e-96 321.4 0.1 2.9e-96 321.1 0.1 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 AMD18768.1 - 0.00023 20.7 0.1 0.00056 19.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD18768.1 - 0.011 16.1 0.1 0.03 14.8 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 AMD18768.1 - 0.025 14.9 0.0 0.042 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain IF2_N PF04760.10 AMD18768.1 - 0.029 14.0 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Methyltransf_18 PF12847.2 AMD18768.1 - 0.044 14.3 0.0 0.075 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.13 AMD18768.1 - 0.066 12.3 0.0 0.35 10.0 0.0 2.1 1 1 2 3 3 3 0 O-methyltransferase Med1 PF10744.4 AMD18769.1 - 2.2e-54 184.7 6.3 1.9e-52 178.3 4.4 2.1 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 NUDIX PF00293.23 AMD18770.1 - 4.8e-20 71.5 0.1 8.3e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain EnY2 PF10163.4 AMD18771.1 - 1.2e-26 92.4 1.8 1.3e-26 92.2 1.2 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF3887 PF13026.1 AMD18771.1 - 0.097 12.9 0.9 0.18 12.0 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3887) TPR_1 PF00515.23 AMD18772.1 - 3.1e-52 172.1 13.9 1.9e-07 30.3 0.0 10.2 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_11 PF13414.1 AMD18772.1 - 1.1e-45 153.1 20.7 6.2e-11 41.7 0.4 6.5 2 2 4 7 7 7 7 TPR repeat TPR_2 PF07719.12 AMD18772.1 - 5.5e-45 147.6 19.0 0.00011 21.8 0.0 9.9 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_12 PF13424.1 AMD18772.1 - 1.1e-31 108.5 27.6 1.3e-08 34.6 0.3 7.3 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_17 PF13431.1 AMD18772.1 - 1.4e-30 102.8 20.7 0.00093 19.2 0.1 11.4 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_16 PF13432.1 AMD18772.1 - 4.5e-30 103.6 18.4 1.6e-06 28.5 0.0 6.6 4 2 1 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.1 AMD18772.1 - 2.3e-29 98.9 16.0 0.0097 15.6 0.0 10.4 8 1 2 10 10 10 8 Tetratricopeptide repeat TPR_14 PF13428.1 AMD18772.1 - 9.5e-26 87.9 20.9 0.003 18.0 0.0 10.1 2 2 8 10 10 10 7 Tetratricopeptide repeat TPR_7 PF13176.1 AMD18772.1 - 1.5e-22 77.5 20.5 0.0012 18.4 0.2 9.5 9 1 1 10 10 9 7 Tetratricopeptide repeat TPR_19 PF14559.1 AMD18772.1 - 8.1e-19 67.7 16.6 0.0041 17.4 1.1 6.8 4 3 2 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.1 AMD18772.1 - 1.2e-18 66.1 16.5 0.27 11.7 0.0 9.9 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_9 PF13371.1 AMD18772.1 - 7.7e-15 54.5 18.5 1.6e-06 27.8 0.0 5.9 3 2 5 8 8 8 6 Tetratricopeptide repeat Apc3 PF12895.2 AMD18772.1 - 4e-13 49.2 8.9 6e-05 23.1 0.1 4.0 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 AMD18772.1 - 1.4e-10 40.6 14.5 0.0012 17.9 0.1 4.8 1 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.1 AMD18772.1 - 1.7 8.7 32.6 0.038 13.9 0.5 7.9 8 1 1 9 9 8 0 Tetratricopeptide repeat SNF2_N PF00176.18 AMD18773.1 - 5e-73 245.5 0.2 7.1e-73 245.0 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD18773.1 - 2e-10 40.3 0.0 4.3e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD18773.1 - 2.4e-08 34.0 0.0 4.5e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.20 AMD18773.1 - 6.3e-08 32.1 9.6 6.3e-08 32.1 6.7 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.24 AMD18773.1 - 5.1e-07 29.3 0.0 1.2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.1 AMD18773.1 - 2.8e-05 24.0 8.2 0.00011 22.1 5.7 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD18773.1 - 2.8e-05 23.8 8.2 2.8e-05 23.8 5.7 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 AMD18773.1 - 0.0012 18.5 7.1 0.0012 18.5 4.9 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 AMD18773.1 - 0.015 15.1 8.6 0.015 15.1 6.0 2.3 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 AMD18773.1 - 0.016 15.3 4.5 0.04 14.0 3.1 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger DEAD_2 PF06733.10 AMD18773.1 - 0.017 14.5 0.5 0.12 11.7 0.3 2.3 1 1 0 1 1 1 0 DEAD_2 AAA_34 PF13872.1 AMD18773.1 - 0.11 11.3 0.2 0.46 9.1 0.1 2.1 2 1 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 zf-Nse PF11789.3 AMD18773.1 - 1.1 8.8 6.2 2.6 7.6 4.3 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-Apc11 PF12861.2 AMD18773.1 - 4.9 7.0 10.6 0.046 13.5 1.2 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger NAD_binding_4 PF07993.7 AMD18774.1 - 2.4e-70 236.2 0.0 3.7e-70 235.6 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.23 AMD18774.1 - 9.4e-70 235.0 0.0 1.3e-69 234.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.16 AMD18774.1 - 5.3e-16 58.7 0.0 9.5e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.20 AMD18774.1 - 9.7e-15 54.5 0.0 4.4e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.14 AMD18774.1 - 1.8e-05 23.6 0.0 5.2e-05 22.0 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.1 AMD18774.1 - 5.2e-05 24.0 0.0 0.00016 22.5 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Polysacc_synt_2 PF02719.10 AMD18774.1 - 0.0019 17.1 0.1 0.0047 15.8 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Not3 PF04065.10 AMD18775.1 - 2.5e-78 262.5 32.9 6.6e-76 254.6 22.8 2.3 1 1 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 AMD18775.1 - 3.1e-38 130.7 0.3 1.1e-37 128.9 0.2 2.0 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family LELP1 PF15042.1 AMD18775.1 - 0.031 14.4 4.1 0.059 13.5 2.8 1.4 1 0 0 1 1 1 0 Late cornified envelope-like proline-rich protein 1 Complex1_LYR_2 PF13233.1 AMD18775.1 - 0.13 12.7 4.9 5.9 7.4 3.4 3.1 2 1 0 2 2 2 0 Complex1_LYR-like CK2S PF15011.1 AMD18775.1 - 0.2 11.4 5.3 0.43 10.3 0.5 2.5 2 0 0 2 2 2 0 Casein Kinase 2 substrate Cep57_MT_bd PF06657.8 AMD18775.1 - 1.2 9.1 12.0 0.15 11.9 3.1 2.9 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 L31 PF09784.4 AMD18775.1 - 7.3 6.7 9.0 46 4.1 2.7 2.9 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 LMWPc PF01451.16 AMD18776.1 - 4.1e-41 140.5 0.0 4.6e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase DUF1412 PF07203.6 AMD18776.1 - 0.12 12.3 0.2 0.29 11.1 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1412) Transketolase_N PF00456.16 AMD18777.1 - 8.6e-154 511.2 0.0 2.3e-153 509.9 0.0 1.6 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 AMD18777.1 - 5.8e-45 152.9 0.0 9.7e-45 152.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 AMD18777.1 - 3e-13 49.7 0.0 6.4e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 AMD18777.1 - 1.1e-05 24.5 0.1 0.0017 17.3 0.1 2.7 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_N PF02776.13 AMD18777.1 - 0.0058 16.1 0.0 2.9 7.3 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain E1_dh PF00676.15 AMD18777.1 - 0.0094 14.7 0.0 0.023 13.4 0.0 1.5 2 0 0 2 2 2 1 Dehydrogenase E1 component Opy2 PF09463.5 AMD18778.1 - 1.5e-07 31.3 21.2 2.2e-07 30.8 14.7 1.3 1 0 0 1 1 1 1 Opy2 protein DUF912 PF06024.7 AMD18778.1 - 0.00098 19.1 0.1 0.0085 16.1 0.0 2.5 2 1 1 3 3 3 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Syndecan PF01034.15 AMD18778.1 - 0.057 13.0 0.3 0.37 10.4 0.1 2.2 2 0 0 2 2 2 0 Syndecan domain Adeno_E3_CR2 PF02439.10 AMD18778.1 - 0.065 12.7 0.2 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 ABC2_membrane_3 PF12698.2 AMD18778.1 - 0.73 8.8 2.5 0.37 9.7 0.4 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein CIMR PF00878.13 AMD18780.1 - 2.2e-11 43.6 0.5 0.00013 21.7 0.0 2.8 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat PRKCSH_1 PF13015.1 AMD18780.1 - 0.0004 19.8 0.0 0.00067 19.1 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein GTP_EFTU PF00009.22 AMD18781.1 - 1.4e-57 194.1 0.1 2.1e-57 193.6 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 AMD18781.1 - 1.6e-35 121.2 0.0 5.4e-35 119.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 AMD18781.1 - 4.1e-17 62.0 2.5 4.1e-17 62.0 1.7 2.2 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 AMD18781.1 - 8e-06 25.4 0.6 8e-06 25.4 0.4 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 AMD18781.1 - 0.00094 19.1 0.5 0.003 17.5 0.4 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RRM_1 PF00076.17 AMD18782.1 - 2.5e-12 46.2 1.0 1.4e-07 30.9 0.0 3.3 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD18782.1 - 9.5e-12 44.7 0.4 0.00011 22.1 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD18782.1 - 1.5e-06 27.9 0.2 0.0019 18.0 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RecX PF02631.11 AMD18782.1 - 0.14 12.4 2.6 0.2 11.8 0.3 2.2 1 1 1 2 2 2 0 RecX family DUF221 PF02714.10 AMD18782.1 - 0.23 10.2 0.3 0.86 8.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF221 Chorein_N PF12624.2 AMD18783.1 - 0.0018 17.8 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter tRNA-synt_2b PF00587.20 AMD18784.1 - 4.1e-69 231.6 0.1 7.9e-69 230.6 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AMD18784.1 - 6.7e-22 77.2 0.2 3.2e-21 75.0 0.0 2.3 2 0 0 2 2 2 1 Anticodon binding domain DIM1 PF02966.11 AMD18785.1 - 5.9e-69 229.7 0.8 6.7e-69 229.5 0.6 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 tRNA_m1G_MT PF01746.16 AMD18786.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase Tau95 PF09734.4 AMD18787.1 - 4.1e-55 187.2 0.5 5.5e-55 186.8 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit PP2C PF00481.16 AMD18788.1 - 6.5e-63 212.4 0.0 2.4e-62 210.6 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 AMD18788.1 - 0.0024 17.3 0.0 0.007 15.7 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C Glyco_transf_20 PF00982.16 AMD18789.1 - 2.4e-199 662.7 0.1 2.8e-199 662.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.15 AMD18789.1 - 0.0011 18.3 0.1 0.18 11.2 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 AMD18789.1 - 0.0078 15.7 0.3 0.015 14.7 0.1 1.6 2 0 0 2 2 2 1 Starch synthase catalytic domain HMG_box_5 PF14887.1 AMD18790.1 - 0.06 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box 5 ATP-synt_ab PF00006.20 AMD18791.1 - 2.8e-61 206.7 0.0 3.8e-61 206.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 AMD18791.1 - 4.6e-16 59.2 0.0 9.9e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 AMD18791.1 - 1e-13 51.2 0.5 2.2e-13 50.1 0.3 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Atg14 PF10186.4 AMD18792.1 - 4e-34 117.9 8.7 1.4e-33 116.1 6.0 1.7 1 1 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 MORN_2 PF07661.8 AMD18793.1 - 0.0017 18.1 1.0 0.025 14.5 0.2 2.8 2 0 0 2 2 2 1 MORN repeat variant Ras PF00071.17 AMD18793.1 - 0.0054 16.1 0.0 1.9 7.8 0.0 2.7 3 0 0 3 3 3 2 Ras family AAA_28 PF13521.1 AMD18793.1 - 0.014 15.3 0.0 0.031 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 AMD18793.1 - 0.069 13.1 0.1 1.3 8.9 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase WD40 PF00400.27 AMD18794.1 - 9e-08 31.7 0.0 6.1e-05 22.7 0.1 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat PH PF00169.24 AMD18795.1 - 1.9e-12 47.3 4.2 1.8e-05 24.8 0.6 3.1 2 1 1 3 3 3 2 PH domain PH_11 PF15413.1 AMD18795.1 - 0.00031 20.9 0.9 0.043 14.0 0.1 2.6 2 1 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.1 AMD18795.1 - 0.063 13.3 0.0 13 5.8 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain APG17 PF04108.7 AMD18796.1 - 0.0015 17.4 10.7 0.0015 17.4 7.4 2.1 1 1 1 2 2 2 1 Autophagy protein Apg17 MCPsignal PF00015.16 AMD18796.1 - 0.01 15.3 3.4 0.025 14.1 2.4 1.6 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2096 PF09869.4 AMD18796.1 - 0.011 15.6 4.3 0.011 15.6 3.0 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) TMF_DNA_bd PF12329.3 AMD18796.1 - 0.011 15.5 9.4 0.011 15.5 6.5 4.0 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.3 AMD18796.1 - 0.013 15.2 5.6 0.013 15.2 3.9 3.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.6 AMD18796.1 - 0.093 11.3 27.9 0.0059 15.3 13.0 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF2316 PF10078.4 AMD18796.1 - 0.11 12.4 0.1 0.11 12.4 0.1 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) Taxilin PF09728.4 AMD18796.1 - 0.12 11.4 28.9 0.27 10.2 19.9 1.6 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Snapin_Pallidin PF14712.1 AMD18796.1 - 0.13 12.5 22.3 0.99 9.7 1.7 3.5 1 1 1 3 3 3 0 Snapin/Pallidin SlyX PF04102.7 AMD18796.1 - 0.33 11.3 0.1 0.33 11.3 0.1 3.9 3 1 1 4 4 4 0 SlyX Ded_cyto PF06920.8 AMD18796.1 - 0.45 9.7 12.8 0.28 10.4 3.0 2.8 1 1 0 2 2 2 0 Dedicator of cytokinesis Cluap1 PF10234.4 AMD18796.1 - 0.46 9.6 22.8 0.069 12.3 5.3 2.0 1 1 1 2 2 2 0 Clusterin-associated protein-1 CENP-F_leu_zip PF10473.4 AMD18796.1 - 0.47 10.2 28.6 1.7 8.4 9.9 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Peptidase_S46 PF10459.4 AMD18796.1 - 0.66 8.3 14.9 0.95 7.8 10.3 1.3 1 0 0 1 1 1 0 Peptidase S46 GAS PF13851.1 AMD18796.1 - 0.99 8.5 32.6 2.1 7.5 22.3 1.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ADIP PF11559.3 AMD18796.1 - 1.2 9.0 27.1 0.14 12.0 9.9 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4164 PF13747.1 AMD18796.1 - 1.6 8.9 15.4 0.15 12.1 1.1 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF4164) NPV_P10 PF05531.7 AMD18796.1 - 1.6 9.0 9.2 8.1 6.7 0.0 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein IncA PF04156.9 AMD18796.1 - 3.3 7.2 25.3 0.24 10.9 8.0 2.3 1 1 1 2 2 2 0 IncA protein Reo_sigmaC PF04582.7 AMD18796.1 - 3.8 6.5 11.2 1.9 7.5 0.0 2.7 2 1 2 4 4 4 0 Reovirus sigma C capsid protein DUF3552 PF12072.3 AMD18796.1 - 3.9 6.6 28.4 0.19 10.9 5.6 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF3552) CENP-Q PF13094.1 AMD18796.1 - 4.6 7.2 23.5 0.9 9.5 10.2 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit COG5 PF10392.4 AMD18796.1 - 6.2 6.7 16.7 4.1 7.3 4.4 2.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 SRP54 PF00448.17 AMD18797.1 - 1.3e-78 263.0 2.3 1.3e-78 263.0 1.6 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 AMD18797.1 - 3.8e-25 88.1 7.6 3.8e-25 88.1 5.3 4.3 4 0 0 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.14 AMD18797.1 - 3.5e-11 43.0 2.9 3.5e-11 43.0 2.0 1.9 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 AMD18797.1 - 1.7e-06 27.6 1.4 1.1e-05 24.9 0.5 2.6 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.18 AMD18797.1 - 8.4e-06 25.3 2.4 2.9e-05 23.5 0.2 2.9 3 1 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.1 AMD18797.1 - 9.5e-06 25.5 0.0 5.4e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_31 PF13614.1 AMD18797.1 - 9.5e-05 22.3 0.2 0.032 14.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain MobB PF03205.9 AMD18797.1 - 0.00011 21.9 0.8 0.00032 20.4 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B VirE PF05272.6 AMD18797.1 - 0.0032 16.9 0.1 0.011 15.1 0.0 1.9 1 1 0 1 1 1 1 Virulence-associated protein E AAA_17 PF13207.1 AMD18797.1 - 0.0049 17.6 0.0 0.01 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD18797.1 - 0.0073 16.4 0.1 0.036 14.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 AMD18797.1 - 0.008 15.4 4.6 0.93 8.6 0.1 3.5 3 1 1 4 4 4 2 Signal recognition particle receptor beta subunit AAA_10 PF12846.2 AMD18797.1 - 0.012 15.0 0.4 0.037 13.4 0.1 1.9 2 0 0 2 2 2 0 AAA-like domain AAA_30 PF13604.1 AMD18797.1 - 0.013 15.0 0.3 0.066 12.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 AMD18797.1 - 0.02 14.4 0.1 0.07 12.6 0.1 2.0 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.1 AMD18797.1 - 0.033 14.4 0.1 0.14 12.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain APS_kinase PF01583.15 AMD18797.1 - 0.041 13.5 0.2 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase MipZ PF09140.6 AMD18797.1 - 0.041 12.9 0.2 0.97 8.4 0.1 2.5 1 1 0 1 1 1 0 ATPase MipZ AAA_25 PF13481.1 AMD18797.1 - 0.078 12.3 0.2 0.45 9.8 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.1 AMD18797.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ArsA_ATPase PF02374.10 AMD18797.1 - 2.1 7.3 10.6 0.52 9.2 0.1 3.9 4 0 0 4 4 4 0 Anion-transporting ATPase DUF1712 PF08217.6 AMD18798.1 - 5.8e-160 533.4 6.1 7e-160 533.1 4.2 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Stig1 PF04885.8 AMD18799.1 - 0.019 15.1 6.0 0.03 14.5 4.1 1.3 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 AA_permease PF00324.16 AMD18800.1 - 3.2e-109 365.4 37.9 3.8e-109 365.1 26.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD18800.1 - 2.6e-20 72.3 41.0 3.6e-20 71.9 28.4 1.1 1 0 0 1 1 1 1 Amino acid permease DIL PF01843.14 AMD18801.1 - 1.3e-14 53.8 3.1 1.2e-07 31.5 0.3 3.3 3 0 0 3 3 3 2 DIL domain Ank_5 PF13857.1 AMD18801.1 - 5.5e-08 32.7 0.5 0.00014 21.9 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD18801.1 - 6.7e-06 26.3 0.0 1.7e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 AMD18801.1 - 3.1e-05 24.3 0.0 0.47 11.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) PRMT5 PF05185.11 AMD18802.1 - 6.4e-150 499.9 2.4 9e-150 499.4 1.7 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CKS PF01111.14 AMD18803.1 - 3.3e-35 119.7 0.1 5e-35 119.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit PI3_PI4_kinase PF00454.22 AMD18804.1 - 1e-47 162.5 0.3 5e-47 160.3 0.2 2.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.8 AMD18804.1 - 2.1e-30 104.8 1.7 1.4e-29 102.1 0.2 3.4 3 0 0 3 3 3 1 UME (NUC010) domain FATC PF02260.15 AMD18804.1 - 1.2e-14 53.4 0.4 4.2e-14 51.6 0.3 2.0 1 0 0 1 1 1 1 FATC domain TPR_11 PF13414.1 AMD18804.1 - 0.019 14.5 3.0 0.99 9.1 0.1 3.7 3 0 0 3 3 3 0 TPR repeat zf-primase PF09329.6 AMD18804.1 - 0.061 12.9 0.7 0.17 11.5 0.5 1.7 1 0 0 1 1 1 0 Primase zinc finger DUF2404 PF10296.4 AMD18805.1 - 8.1e-30 102.8 0.2 1.7e-29 101.7 0.1 1.6 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) PH PF00169.24 AMD18805.1 - 0.00012 22.2 1.4 0.00043 20.4 0.2 2.7 2 0 0 2 2 2 1 PH domain K1377 PF15352.1 AMD18806.1 - 0.053 11.4 0.1 0.069 11.0 0.1 1.1 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy Cofilin_ADF PF00241.15 AMD18807.1 - 2.3e-23 82.4 0.1 3.7e-12 46.2 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Orthopox_A49R PF06489.6 AMD18807.1 - 0.027 14.4 0.2 0.049 13.6 0.1 1.4 1 0 0 1 1 1 0 Orthopoxvirus A49R protein zf-RING_2 PF13639.1 AMD18808.1 - 1.6e-08 34.2 13.8 2.6e-08 33.5 9.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 AMD18808.1 - 2.1e-05 24.0 12.7 3.4e-05 23.3 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 AMD18808.1 - 8.5e-05 22.5 12.2 0.00018 21.5 8.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 AMD18808.1 - 0.00012 21.7 10.5 0.00019 21.1 7.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 AMD18808.1 - 0.00017 21.1 10.5 0.00026 20.6 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 AMD18808.1 - 0.00086 19.1 6.6 0.00086 19.1 4.6 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 AMD18808.1 - 0.0048 16.8 13.4 0.0082 16.1 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 AMD18808.1 - 0.072 12.6 11.2 0.14 11.7 7.7 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.7 AMD18808.1 - 0.16 12.1 6.6 0.57 10.3 0.3 2.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-HC5HC2H PF13771.1 AMD18808.1 - 0.72 10.0 6.2 0.51 10.5 1.7 2.2 1 1 0 2 2 2 0 PHD-like zinc-binding domain zf-C3HC4_4 PF15227.1 AMD18808.1 - 1.2 9.0 10.0 3.6 7.5 7.0 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.24 AMD18808.1 - 9.5 5.9 11.4 18 5.1 7.9 1.5 1 0 0 1 1 1 0 PHD-finger PHF5 PF03660.9 AMD18809.1 - 6e-51 171.0 11.9 6.7e-51 170.8 8.3 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.8 AMD18809.1 - 0.32 8.6 7.5 0.36 8.4 5.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Sec7 PF01369.15 AMD18810.1 - 4.4e-32 111.2 4.7 1e-31 110.0 3.2 1.6 1 0 0 1 1 1 1 Sec7 domain PH PF00169.24 AMD18810.1 - 0.00032 20.8 0.5 0.011 15.9 0.0 3.0 2 1 0 2 2 2 1 PH domain PH_9 PF15410.1 AMD18810.1 - 0.0016 18.6 0.0 0.0038 17.3 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.1 AMD18810.1 - 0.048 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4149 PF13664.1 AMD18811.1 - 1.9e-17 63.1 2.0 1.9e-17 63.1 1.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) MAS20 PF02064.10 AMD18812.1 - 7.3e-17 61.3 0.8 5.6e-16 58.5 0.5 1.9 1 1 0 1 1 1 1 MAS20 protein import receptor PfkB PF00294.19 AMD18812.1 - 0.038 13.1 0.1 0.06 12.4 0.1 1.2 1 0 0 1 1 1 0 pfkB family carbohydrate kinase SLX9 PF15341.1 AMD18813.1 - 1.1e-22 80.7 7.0 1.1e-22 80.7 4.9 1.7 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 Apolipoprotein PF01442.13 AMD18813.1 - 0.043 13.3 0.1 0.066 12.7 0.1 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF3818 PF12825.2 AMD18814.1 - 6.4e-100 334.1 3.0 6.4e-100 334.1 2.1 2.1 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 AMD18814.1 - 5.6e-43 145.8 1.5 5.6e-43 145.8 1.0 2.5 2 0 0 2 2 2 1 PX-associated PX PF00787.19 AMD18814.1 - 1.8e-11 43.8 0.9 7.8e-11 41.7 0.0 2.6 3 0 0 3 3 3 1 PX domain L51_S25_CI-B8 PF05047.11 AMD18815.1 - 8.7e-13 47.8 0.0 1.4e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain IF-2B PF01008.12 AMD18816.1 - 1e-103 346.2 0.1 1e-103 346.2 0.1 1.6 2 0 0 2 2 2 1 Initiation factor 2 subunit family LMBR1 PF04791.11 AMD18816.1 - 5.6 5.4 9.6 13 4.2 6.7 1.6 1 0 0 1 1 1 0 LMBR1-like membrane protein BCAS2 PF05700.6 AMD18818.1 - 0.00032 20.2 8.6 0.00065 19.2 5.9 1.5 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) AFG1_ATPase PF03969.11 AMD18818.1 - 0.071 11.9 0.8 0.1 11.3 0.5 1.2 1 0 0 1 1 1 0 AFG1-like ATPase DUF1640 PF07798.6 AMD18818.1 - 0.26 11.3 2.8 0.65 10.0 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Ribosomal_L5_C PF00673.16 AMD18819.1 - 3.5e-23 81.1 0.0 5e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 AMD18819.1 - 3e-20 71.7 0.1 8.6e-20 70.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 Proteasome PF00227.21 AMD18820.1 - 3.2e-48 163.5 0.1 3.9e-48 163.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Fork_head PF00250.13 AMD18821.1 - 5.2e-32 109.7 0.4 1.7e-31 108.1 0.3 1.8 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 AMD18821.1 - 5e-11 42.5 0.2 1.1e-10 41.4 0.1 1.6 1 0 0 1 1 1 1 FHA domain COG4 PF08318.7 AMD18822.1 - 3.4e-101 338.3 2.9 3.4e-101 338.3 2.0 2.0 2 0 0 2 2 2 1 COG4 transport protein DUF2935 PF11155.3 AMD18822.1 - 0.14 12.2 8.1 0.29 11.2 2.0 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Pil1 PF13805.1 AMD18823.1 - 2.9e-154 512.0 0.3 3.3e-154 511.8 0.2 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.6 AMD18823.1 - 0.045 13.0 1.5 0.069 12.4 1.0 1.2 1 0 0 1 1 1 0 FAM92 protein Pkinase PF00069.20 AMD18824.1 - 6.7e-21 74.6 0.0 9.3e-21 74.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18824.1 - 3.5e-08 32.8 0.0 5.2e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AMD18824.1 - 0.0044 16.7 0.0 0.06 13.0 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 AMD18824.1 - 0.014 14.3 0.0 0.063 12.2 0.0 1.9 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.17 AMD18824.1 - 0.049 12.9 0.0 0.086 12.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family zf-CCCH PF00642.19 AMD18825.1 - 2.2e-13 49.5 25.9 0.0018 17.9 0.4 5.5 5 1 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 AMD18825.1 - 0.014 15.3 22.3 1.4 9.0 0.3 5.2 4 1 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type FUN14 PF04930.10 AMD18826.1 - 4.6e-07 30.0 2.2 1e-06 28.9 1.5 1.6 1 1 0 1 1 1 1 FUN14 family PsbX PF06596.6 AMD18826.1 - 0.16 11.6 5.5 2.8 7.7 0.3 2.4 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) B56 PF01603.15 AMD18827.1 - 1.5e-145 484.8 15.2 2e-138 461.4 7.3 2.1 2 0 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) ORC6 PF05460.8 AMD18827.1 - 4.3 6.3 12.5 9.1 5.2 8.6 1.5 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Spo7 PF03907.8 AMD18828.1 - 9e-90 299.8 8.2 1.1e-89 299.5 5.7 1.1 1 0 0 1 1 1 1 Spo7-like protein OPT PF03169.10 AMD18828.1 - 0.0024 16.4 0.0 0.0031 16.0 0.0 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3671 PF12420.3 AMD18828.1 - 0.01 15.7 0.1 0.023 14.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF3722 PF12519.3 AMD18829.1 - 1.2e-76 257.3 6.5 2.1e-76 256.5 4.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) H_lectin PF09458.5 AMD18829.1 - 0.11 12.1 2.0 0.12 12.0 0.2 1.9 2 0 0 2 2 2 0 H-type lectin domain SMC_N PF02463.14 AMD18831.1 - 1.7e-19 69.9 19.4 1.2e-18 67.1 13.5 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 AMD18831.1 - 3.4e-13 50.3 32.1 3.4e-13 50.3 22.3 5.7 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.1 AMD18831.1 - 3.3e-05 23.9 0.1 3.3e-05 23.9 0.1 3.4 2 2 0 3 3 3 1 AAA domain AAA_29 PF13555.1 AMD18831.1 - 4.1e-05 23.0 0.0 8.7e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_10 PF12846.2 AMD18831.1 - 0.0077 15.7 8.2 0.04 13.3 1.0 3.0 2 1 0 2 2 2 2 AAA-like domain AAA_25 PF13481.1 AMD18831.1 - 0.011 15.2 2.1 0.019 14.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain NACHT PF05729.7 AMD18831.1 - 0.013 15.1 0.0 0.064 12.9 0.0 2.3 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 AMD18831.1 - 0.034 14.4 0.0 0.034 14.4 0.0 5.0 4 2 0 4 4 4 0 ABC transporter FtsK_SpoIIIE PF01580.13 AMD18831.1 - 0.26 10.7 4.2 0.27 10.7 0.0 2.8 2 1 0 2 2 2 0 FtsK/SpoIIIE family DASH_Dam1 PF08653.5 AMD18831.1 - 2.2 8.1 5.6 31 4.4 0.1 4.2 4 0 0 4 4 4 0 DASH complex subunit Dam1 tRNA-synt_1c PF00749.16 AMD18832.1 - 8.7e-107 356.4 0.0 1.2e-106 355.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DUF775 PF05603.7 AMD18833.1 - 1.2e-57 194.7 0.1 1.3e-57 194.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) DUF515 PF04415.7 AMD18833.1 - 0.0037 15.5 0.0 0.0053 15.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF515) Cys_Met_Meta_PP PF01053.15 AMD18835.1 - 4.2e-145 482.8 0.1 4.8e-145 482.6 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 AMD18835.1 - 1.1e-07 31.2 0.4 2.6e-07 29.9 0.2 1.6 1 1 1 2 2 2 1 Aminotransferase class I and II Met_gamma_lyase PF06838.6 AMD18835.1 - 2.5e-05 22.7 0.0 3.3e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.16 AMD18835.1 - 0.0035 16.5 0.0 0.011 14.9 0.0 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.11 AMD18835.1 - 0.015 13.9 0.1 0.024 13.3 0.1 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein Aminotran_5 PF00266.14 AMD18835.1 - 0.028 13.1 0.0 0.043 12.5 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 AMD18835.1 - 0.03 13.3 0.1 0.13 11.2 0.0 1.9 2 1 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Ribosomal_60s PF00428.14 AMD18836.1 - 3.1e-24 85.1 11.9 3.6e-24 84.9 8.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein KfrA_N PF11740.3 AMD18836.1 - 0.016 15.6 2.7 0.022 15.2 1.9 1.2 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term Ribosomal_S19 PF00203.16 AMD18837.1 - 1e-31 108.3 0.1 1.4e-31 107.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Sds3 PF08598.6 AMD18838.1 - 1.5e-47 161.7 0.1 1.5e-47 161.7 0.1 2.2 2 0 0 2 2 2 1 Sds3-like RRM_1 PF00076.17 AMD18839.1 - 9.2e-19 66.8 1.0 3.6e-16 58.5 0.1 3.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD18839.1 - 5.9e-15 55.0 1.2 3.9e-12 45.9 0.0 3.3 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD18839.1 - 5e-10 39.0 0.7 5.2e-07 29.4 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Daxx PF03344.10 AMD18839.1 - 0.99 7.8 28.2 0.008 14.7 14.1 1.5 2 0 0 2 2 2 0 Daxx Family Hid1 PF12722.2 AMD18839.1 - 2.3 5.8 11.3 3.2 5.3 7.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SNARE PF05739.14 AMD18840.1 - 3.9e-07 29.6 4.3 2.9e-06 26.8 1.7 2.7 2 0 0 2 2 2 1 SNARE domain P16-Arc PF04699.9 AMD18840.1 - 0.21 11.5 4.3 4 7.4 0.1 2.3 2 0 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Astro_capsid PF03115.9 AMD18840.1 - 1.7 6.7 4.4 1.8 6.7 3.0 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Med25_NR-box PF11244.3 AMD18840.1 - 5.4 7.5 11.4 3.3 8.2 0.9 2.2 2 0 0 2 2 2 0 Mediator complex subunit 25 C-terminal NR box-containing HhH-GPD PF00730.20 AMD18842.1 - 3.9e-18 65.7 0.0 6.6e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 AMD18842.1 - 1.2e-05 24.7 0.1 4.9e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif HEAT PF02985.17 AMD18843.1 - 1.9e-44 145.7 26.7 0.00096 19.0 0.1 13.1 13 1 0 13 13 13 12 HEAT repeat HEAT_2 PF13646.1 AMD18843.1 - 2.4e-33 114.2 4.1 1.8e-06 28.1 0.0 7.4 2 1 5 8 8 8 8 HEAT repeats Vac14_Fab1_bd PF12755.2 AMD18843.1 - 8.6e-15 54.9 9.4 0.034 14.5 0.3 8.7 3 3 5 9 9 9 4 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 AMD18843.1 - 1.1e-14 54.3 12.2 0.36 11.3 0.1 9.0 8 2 1 9 9 9 6 HEAT-like repeat Ecm29 PF13001.2 AMD18843.1 - 0.00043 18.8 4.8 0.037 12.5 0.1 3.1 3 0 0 3 3 3 2 Proteasome stabiliser M11L PF11099.3 AMD18843.1 - 0.0014 18.4 0.3 0.25 11.0 0.0 3.4 3 1 1 4 4 4 1 Apoptosis regulator M11L like UNC45-central PF11701.3 AMD18843.1 - 0.0032 17.1 4.4 0.058 13.0 0.3 3.8 3 1 1 4 4 4 1 Myosin-binding striated muscle assembly central DUF2435 PF10363.4 AMD18843.1 - 0.094 12.6 7.4 8.1 6.4 0.1 4.9 3 1 0 5 5 5 0 Protein of unknown function (DUF2435) Arm PF00514.18 AMD18843.1 - 0.41 10.5 10.9 1.4 8.8 0.0 6.2 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat API5 PF05918.6 AMD18843.1 - 10 4.5 8.2 1.1 7.7 0.2 3.2 3 2 2 5 5 5 0 Apoptosis inhibitory protein 5 (API5) Pkinase PF00069.20 AMD18845.1 - 1.3e-58 198.1 0.0 2.5e-58 197.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18845.1 - 2.4e-20 72.6 0.0 4.1e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD18845.1 - 6.4e-06 25.3 0.0 1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD18845.1 - 0.00024 20.2 0.0 0.00059 18.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD18845.1 - 0.0006 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ribonuc_2-5A PF06479.7 AMD18845.1 - 0.0047 16.7 0.5 0.011 15.6 0.4 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A PAS_9 PF13426.1 AMD18845.1 - 0.0071 16.6 0.0 1.7 9.0 0.0 2.6 2 0 0 2 2 2 1 PAS domain EI24 PF07264.6 AMD18847.1 - 0.021 14.2 25.4 0.1 11.9 17.6 1.9 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) GSH_synth_ATP PF03917.12 AMD18848.1 - 2.2e-116 388.5 0.0 2.6e-116 388.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 AMD18848.1 - 5.5e-36 122.8 0.0 1e-35 122.0 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Med15_fungi PF05397.7 AMD18849.1 - 3.1e-40 136.7 6.6 3.1e-40 136.7 4.6 8.8 5 2 1 6 6 6 1 Mediator complex subunit 15 SNF2_N PF00176.18 AMD18850.1 - 3.4e-69 232.9 1.0 7.5e-69 231.7 0.7 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD18850.1 - 9.4e-18 63.8 0.1 2.8e-15 55.9 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 AMD18850.1 - 9.2e-10 38.2 0.0 2.6e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase CUE PF02845.11 AMD18850.1 - 0.0028 17.1 0.0 0.0071 15.8 0.0 1.8 1 0 0 1 1 1 1 CUE domain AAA_22 PF13401.1 AMD18850.1 - 0.058 13.5 0.0 0.21 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain RCC1 PF00415.13 AMD18851.1 - 1.7e-27 95.3 14.3 4.3e-09 36.4 0.1 6.6 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 AMD18851.1 - 7.7e-20 69.9 19.3 7.1e-09 35.0 0.0 6.5 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.1 AMD18851.1 - 0.011 15.4 0.3 14 5.5 0.0 3.7 3 0 0 3 3 3 0 Galactose oxidase, central domain Exo_endo_phos PF03372.18 AMD18852.1 - 3.3e-24 86.2 0.1 5.3e-24 85.5 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.2 AMD18852.1 - 4.8e-17 61.1 13.7 8.7e-11 41.1 2.3 3.5 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 AMD18852.1 - 2e-11 42.2 7.4 0.0019 17.9 0.1 5.2 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_8 PF13855.1 AMD18852.1 - 2.1e-11 43.3 2.5 5.3e-11 42.1 0.5 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_7 PF13504.1 AMD18852.1 - 1.6e-06 27.3 10.5 0.006 16.5 0.1 5.4 5 0 0 5 5 5 2 Leucine rich repeat LRR_6 PF13516.1 AMD18852.1 - 0.22 11.6 8.7 1.5 9.1 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich repeat BAF1_ABF1 PF04684.8 AMD18853.1 - 8.8e-141 470.1 33.5 6.8e-121 404.5 8.7 3.2 1 1 1 2 2 2 2 BAF1 / ABF1 chromatin reorganising factor DBD_Tnp_Mut PF03108.10 AMD18853.1 - 0.00039 19.9 0.0 0.00084 18.8 0.0 1.5 1 0 0 1 1 1 1 MuDR family transposase Ydc2-catalyt PF09159.5 AMD18853.1 - 0.0075 15.7 1.3 0.021 14.3 0.8 1.8 2 0 0 2 2 2 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 DUF2141 PF09912.4 AMD18853.1 - 0.011 15.4 0.0 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) MOR2-PAG1_N PF14222.1 AMD18853.1 - 0.048 12.3 0.1 0.077 11.6 0.0 1.2 1 0 0 1 1 1 0 Cell morphogenesis N-terminal Zip PF02535.17 AMD18853.1 - 0.47 9.4 8.1 0.8 8.6 5.6 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter mRNA_stabil PF13929.1 AMD18854.1 - 6.4e-49 166.4 15.0 7.1e-49 166.3 9.4 1.7 2 0 0 2 2 2 1 mRNA stabilisation Oligomerisation PF02410.10 AMD18854.1 - 5.9e-11 42.2 0.0 1.4e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Oligomerisation domain KTI12 PF08433.5 AMD18855.1 - 7.4e-93 310.6 0.1 8.4e-93 310.4 0.1 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 AMD18855.1 - 1.8e-06 27.8 0.0 3.4e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD18855.1 - 6.7e-05 23.1 0.1 0.0002 21.6 0.0 1.8 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.15 AMD18855.1 - 0.00012 21.7 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.1 AMD18855.1 - 0.00013 22.0 0.3 0.0031 17.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD18855.1 - 0.00049 20.9 0.1 0.001 19.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 AMD18855.1 - 0.0052 16.9 0.2 0.035 14.2 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.5 AMD18855.1 - 0.0067 15.6 0.3 0.038 13.1 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Mg_chelatase PF01078.16 AMD18855.1 - 0.015 14.4 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 AMD18855.1 - 0.026 14.2 0.0 0.12 12.1 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF2226 PF09987.4 AMD18855.1 - 0.03 13.4 0.2 0.062 12.4 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2226) AAA_16 PF13191.1 AMD18855.1 - 0.034 14.1 0.0 0.22 11.4 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain NACHT PF05729.7 AMD18855.1 - 0.065 12.8 0.2 0.51 9.9 0.0 2.7 1 1 1 2 2 2 0 NACHT domain SRP54 PF00448.17 AMD18855.1 - 0.069 12.5 0.1 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Thymidylate_kin PF02223.12 AMD18855.1 - 0.075 12.4 0.2 2.3 7.5 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase NTPase_1 PF03266.10 AMD18855.1 - 0.08 12.6 0.1 0.27 10.9 0.0 1.9 1 1 0 1 1 1 0 NTPase cobW PF02492.14 AMD18855.1 - 0.085 12.2 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.1 AMD18855.1 - 0.16 11.7 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain MMR_HSR1 PF01926.18 AMD18856.1 - 2.2e-13 50.1 0.0 1e-12 48.0 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 AMD18856.1 - 2.4e-06 26.8 0.1 3.4e-05 23.0 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 AMD18856.1 - 2.4e-05 23.6 0.0 4.7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 AMD18856.1 - 0.0069 16.8 0.1 0.028 14.8 0.0 2.1 3 0 0 3 3 3 1 Miro-like protein Dynamin_N PF00350.18 AMD18856.1 - 0.016 14.9 0.0 5.1 6.8 0.0 2.5 1 1 1 2 2 2 0 Dynamin family AIG1 PF04548.11 AMD18856.1 - 0.039 13.0 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family AAA_18 PF13238.1 AMD18856.1 - 0.043 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF4218 PF13960.1 AMD18856.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) FtsK_SpoIIIE PF01580.13 AMD18856.1 - 0.14 11.6 0.1 2.8 7.3 0.1 2.3 1 1 0 2 2 2 0 FtsK/SpoIIIE family AAA_17 PF13207.1 AMD18856.1 - 0.16 12.8 0.1 0.6 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 AMD18856.1 - 0.18 10.5 0.1 1.3 7.7 0.0 2.0 1 1 1 2 2 2 0 ArgK protein Hap4_Hap_bind PF10297.4 AMD18857.1 - 8.3e-09 35.0 8.5 1.5e-08 34.2 5.9 1.4 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 HALZ PF02183.13 AMD18857.1 - 0.017 14.8 0.3 0.03 14.0 0.2 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Tmemb_cc2 PF10267.4 AMD18857.1 - 0.095 11.2 0.0 0.095 11.2 0.0 1.7 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DUF904 PF06005.7 AMD18857.1 - 0.18 12.1 1.3 0.33 11.2 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) CENP-H PF05837.7 AMD18857.1 - 0.23 11.6 1.7 0.38 10.9 1.2 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Drc1-Sld2 PF11719.3 AMD18859.1 - 3.9e-52 177.7 25.0 4.3e-35 121.6 11.3 2.2 1 1 1 2 2 2 2 DNA replication and checkpoint protein SPT6_acidic PF14632.1 AMD18859.1 - 0.35 11.0 7.7 3.1 8.0 1.4 2.4 2 0 0 2 2 2 0 Acidic N-terminal SPT6 UTP15_C PF09384.5 AMD18860.1 - 9.5e-53 177.8 0.0 1.4e-52 177.3 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 AMD18860.1 - 3.8e-20 70.9 8.6 1.2e-06 28.1 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat CPSF_A PF03178.10 AMD18860.1 - 0.033 13.2 0.1 0.12 11.4 0.0 1.8 1 1 0 1 1 1 0 CPSF A subunit region WD40 PF00400.27 AMD18861.1 - 8.3e-26 88.8 22.9 0.00036 20.3 0.0 11.3 11 1 0 11 11 11 7 WD domain, G-beta repeat PQQ_2 PF13360.1 AMD18861.1 - 3.2e-07 30.0 5.6 2.8e-06 26.9 0.4 2.9 3 1 0 3 3 3 2 PQQ-like domain eIF2A PF08662.6 AMD18861.1 - 1.3e-05 25.0 0.1 0.036 13.7 0.0 3.5 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Meleagrin PF08189.6 AMD18861.1 - 0.012 15.0 0.6 0.028 13.8 0.4 1.6 1 0 0 1 1 1 0 Meleagrin/Cygnin family CRC_subunit PF08624.5 AMD18862.1 - 2e-57 192.9 0.0 3.2e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit SAPS PF04499.10 AMD18862.1 - 6.5 5.2 7.1 8.6 4.8 4.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Peptidase_M41 PF01434.13 AMD18863.1 - 3e-72 242.5 2.1 3.1e-72 242.4 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.24 AMD18863.1 - 1.3e-42 145.1 0.0 3.2e-42 143.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 AMD18863.1 - 1.5e-09 37.9 0.2 1.5e-09 37.9 0.2 2.3 2 0 0 2 2 2 1 FtsH Extracellular AAA_17 PF13207.1 AMD18863.1 - 0.0001 23.0 0.1 0.00073 20.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 AMD18863.1 - 0.00012 21.7 0.1 0.00086 19.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 AMD18863.1 - 0.0017 17.1 0.0 0.0046 15.7 0.0 1.7 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 AMD18863.1 - 0.0019 17.2 0.0 0.0043 16.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 AMD18863.1 - 0.0022 18.1 0.2 0.12 12.5 0.2 2.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD18863.1 - 0.0046 16.6 1.3 0.016 14.9 0.9 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 AMD18863.1 - 0.0072 16.3 0.1 0.036 14.0 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 AMD18863.1 - 0.024 14.5 0.0 0.072 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 AMD18863.1 - 0.032 13.6 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.1 AMD18863.1 - 0.046 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF883 PF05957.8 AMD18863.1 - 0.051 13.9 0.7 0.18 12.1 0.5 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) AAA_25 PF13481.1 AMD18863.1 - 0.08 12.3 1.2 0.32 10.3 0.3 2.1 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 AMD18863.1 - 0.12 12.2 0.1 0.45 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Macro_2 PF14519.1 AMD18864.1 - 3.3e-61 206.8 0.0 3.7e-61 206.6 0.0 1.0 1 0 0 1 1 1 1 Macro-like domain Aminotran_1_2 PF00155.16 AMD18865.1 - 6.5e-70 235.9 0.0 7.4e-70 235.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Baculo_8kDa PF06096.6 AMD18865.1 - 0.068 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Baculoviridae 8.2 KDa protein LLC1 PF14945.1 AMD18866.1 - 0.15 12.3 5.5 0.26 11.6 0.2 3.1 3 0 0 3 3 3 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Gastrin PF00918.12 AMD18866.1 - 0.46 11.3 3.5 0.4 11.5 0.1 2.7 2 1 0 2 2 2 0 Gastrin/cholecystokinin family SIS PF01380.17 AMD18867.1 - 8.2e-58 193.6 0.2 2.3e-30 104.8 0.2 2.3 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 AMD18867.1 - 5.4e-30 104.2 0.1 5e-21 74.8 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 AMD18867.1 - 6.1e-18 65.0 0.0 1.3e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 AMD18867.1 - 1.7e-11 43.8 0.0 3.9e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 AMD18867.1 - 3.1e-10 39.1 0.0 4.7e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Peptidase_M18 PF02127.10 AMD18868.1 - 3.3e-136 454.2 0.0 4e-136 453.9 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 AMD18868.1 - 2.7e-06 26.3 0.1 0.013 14.2 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase OmpW PF03922.9 AMD18868.1 - 0.052 13.2 0.0 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 OmpW family CDC37_C PF08564.5 AMD18868.1 - 0.23 11.3 0.1 0.23 11.3 0.1 1.9 2 0 0 2 2 2 0 Cdc37 C terminal domain Pkinase PF00069.20 AMD18869.1 - 1.3e-74 250.6 0.0 3.2e-74 249.3 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18869.1 - 4.2e-39 134.1 0.0 9e-39 133.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 AMD18869.1 - 0.00073 19.1 0.8 0.0062 16.1 0.0 2.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kinase-like PF14531.1 AMD18869.1 - 0.0011 17.9 0.0 0.0019 17.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD18869.1 - 0.004 16.2 0.0 0.0081 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD18869.1 - 0.0071 16.0 0.0 0.025 14.3 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family ADH_zinc_N PF00107.21 AMD18870.1 - 1.6e-31 108.5 0.4 2.5e-31 107.9 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AMD18870.1 - 1.4e-29 102.0 0.3 2.4e-29 101.2 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 AMD18870.1 - 2.6e-11 44.5 0.1 5.1e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Utp11 PF03998.8 AMD18871.1 - 2.9e-68 230.3 27.5 3.3e-68 230.1 19.1 1.0 1 0 0 1 1 1 1 Utp11 protein Peptidase_S64 PF08192.6 AMD18871.1 - 0.28 9.4 8.3 0.34 9.2 5.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Ku PF02735.11 AMD18873.1 - 1.7e-34 118.9 0.0 3.4e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 AMD18873.1 - 0.00015 21.3 0.2 0.00022 20.7 0.1 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain CN_hydrolase PF00795.17 AMD18873.1 - 0.091 12.1 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Carbon-nitrogen hydrolase PGM_PMM_I PF02878.11 AMD18874.1 - 7e-35 119.5 0.2 1.2e-34 118.7 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 AMD18874.1 - 2.5e-23 82.2 0.0 5.7e-23 81.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 AMD18874.1 - 2.7e-12 46.9 0.0 8.1e-12 45.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 AMD18874.1 - 5.8e-08 32.6 0.0 1.5e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pkinase PF00069.20 AMD18875.1 - 3e-69 233.0 0.0 5.3e-69 232.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18875.1 - 2.7e-32 111.8 0.0 4.8e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 AMD18875.1 - 7e-10 39.2 0.3 2e-09 37.8 0.2 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 AMD18875.1 - 0.00049 19.1 0.0 0.0017 17.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 AMD18875.1 - 0.011 15.4 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 AMD18875.1 - 0.011 14.7 0.1 0.023 13.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4169 PF13770.1 AMD18875.1 - 0.06 13.2 0.4 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) RRN3 PF05327.6 AMD18876.1 - 1.7e-181 604.2 12.1 2e-181 603.9 8.4 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 SPRY PF00622.23 AMD18877.1 - 6.1e-10 39.2 0.0 2.2e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 SPRY domain SRP9-21 PF05486.7 AMD18878.1 - 4.4e-25 87.2 0.3 7.3e-25 86.5 0.2 1.4 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) GMC_oxred_N PF00732.14 AMD18878.1 - 0.19 10.8 2.7 0.25 10.4 0.1 1.9 1 1 1 2 2 2 0 GMC oxidoreductase WD40 PF00400.27 AMD18879.1 - 2.1e-27 93.9 12.1 3.9e-08 32.8 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 AMD18879.1 - 0.00074 17.9 0.0 0.005 15.1 0.0 2.3 2 1 0 2 2 2 1 Cytochrome D1 heme domain ArfGap PF01412.13 AMD18879.1 - 8 6.2 9.0 13 5.5 0.1 3.8 5 0 0 5 5 5 0 Putative GTPase activating protein for Arf Mito_carr PF00153.22 AMD18880.1 - 3.6e-62 206.1 3.3 2.2e-21 75.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltransf PF01255.14 AMD18881.1 - 3.1e-70 235.8 0.5 4.6e-70 235.2 0.4 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PRESAN PF09687.5 AMD18881.1 - 0.16 11.9 2.1 0.26 11.3 0.5 2.0 2 0 0 2 2 2 0 Plasmodium RESA N-terminal Vma12 PF11712.3 AMD18882.1 - 6.4e-32 110.1 0.0 2.6e-31 108.2 0.0 1.8 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase FliE PF02049.13 AMD18882.1 - 0.01 15.8 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE DUF2339 PF10101.4 AMD18882.1 - 0.04 12.2 0.5 0.048 11.9 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) FAM165 PF14981.1 AMD18882.1 - 0.19 11.2 0.2 0.19 11.2 0.2 2.0 2 0 0 2 2 2 0 FAM165 family zf-MYND PF01753.13 AMD18883.1 - 1e-05 25.3 23.2 2.2e-05 24.2 16.1 1.6 1 1 0 1 1 1 1 MYND finger Abhydrolase_6 PF12697.2 AMD18884.1 - 5.6e-26 91.8 0.1 8e-26 91.3 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD18884.1 - 1.3e-20 73.9 0.1 2e-20 73.3 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AMD18884.1 - 4.2e-10 39.5 0.0 1.3e-09 37.9 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 AMD18884.1 - 0.00042 19.8 0.0 0.00083 18.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Ser_hydrolase PF06821.8 AMD18884.1 - 0.023 14.2 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase AMP-binding PF00501.23 AMD18885.1 - 5.2e-74 249.1 0.0 6.7e-74 248.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme HTH_40 PF14493.1 AMD18885.1 - 0.033 14.4 0.2 0.37 11.0 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain RNase_H PF00075.19 AMD18886.1 - 1.2e-22 80.6 0.0 3.8e-22 79.0 0.0 1.9 1 1 0 1 1 1 1 RNase H Cauli_VI PF01693.11 AMD18886.1 - 2.3e-21 75.5 5.7 2.3e-11 43.5 0.2 3.0 3 0 0 3 3 3 2 Caulimovirus viroplasmin Cu_bind_like PF02298.12 AMD18886.1 - 0.011 15.5 0.4 0.032 14.0 0.2 1.8 1 0 0 1 1 1 0 Plastocyanin-like domain RVT_3 PF13456.1 AMD18886.1 - 0.067 12.9 0.0 9.6 6.0 0.0 2.8 2 1 0 2 2 2 0 Reverse transcriptase-like Membr_traf_MHD PF10540.4 AMD18887.1 - 3.3e-14 52.8 0.0 2.1e-13 50.2 0.0 2.5 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.25 AMD18887.1 - 8.5e-10 38.3 0.3 1.9e-09 37.2 0.2 1.6 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.6 AMD18887.1 - 2.1e-07 29.6 1.7 7.6e-07 27.8 0.5 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF810) SWIB PF02201.13 AMD18888.1 - 1.5e-28 98.2 1.6 2.3e-28 97.6 0.2 1.9 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.6 AMD18888.1 - 4.6e-09 35.9 0.2 2.9e-08 33.3 0.2 2.3 2 0 0 2 2 2 1 DEK C terminal domain DUF3738 PF12543.3 AMD18888.1 - 0.17 11.4 2.4 0.32 10.5 1.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3738) RRS1 PF04939.7 AMD18889.1 - 1.8e-61 206.4 4.0 2e-61 206.2 2.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) RhoGEF PF00621.15 AMD18890.1 - 1.2e-12 48.0 0.4 1.2e-12 48.0 0.3 3.3 2 2 1 3 3 3 2 RhoGEF domain VPS11_C PF12451.3 AMD18891.1 - 8.1e-09 35.2 0.0 8.1e-09 35.2 0.0 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-RING_2 PF13639.1 AMD18891.1 - 3.3e-06 26.8 5.3 8.5e-06 25.5 3.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 AMD18891.1 - 9.9e-06 25.1 6.2 2.4e-05 23.9 4.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 AMD18891.1 - 2.6e-05 24.1 6.1 6.3e-05 22.9 4.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 AMD18891.1 - 0.00052 19.8 4.6 0.0024 17.7 3.3 2.2 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 AMD18891.1 - 0.0051 16.8 2.9 0.015 15.3 2.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 AMD18891.1 - 0.0058 16.4 1.7 0.014 15.1 1.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.24 AMD18891.1 - 0.021 14.5 8.2 0.014 15.1 3.3 2.6 2 0 0 2 2 2 0 PHD-finger zf-C3HC4 PF00097.20 AMD18891.1 - 0.025 14.2 6.9 0.072 12.7 4.8 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.2 AMD18891.1 - 0.043 13.6 1.7 0.095 12.5 1.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-MIZ PF02891.15 AMD18891.1 - 0.093 12.2 3.4 0.31 10.5 2.4 1.9 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_UBOX PF13445.1 AMD18891.1 - 0.12 12.0 3.1 0.5 10.1 2.2 2.1 1 0 0 1 1 1 0 RING-type zinc-finger Pkinase PF00069.20 AMD18892.1 - 4e-66 222.8 0.0 1.1e-65 221.3 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18892.1 - 4.5e-48 163.5 0.1 4.1e-47 160.4 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 AMD18892.1 - 6.8e-35 119.1 0.1 1.9e-34 117.7 0.1 1.8 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 AMD18892.1 - 1.5e-11 43.9 2.0 2.1e-11 43.4 0.0 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 AMD18892.1 - 3.9e-08 33.3 0.0 1.4e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.1 AMD18892.1 - 2.5e-06 26.6 0.0 2.1e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like AFT PF08731.6 AMD18892.1 - 0.019 15.1 0.7 0.047 13.8 0.5 1.7 1 0 0 1 1 1 0 Transcription factor AFT APG6 PF04111.7 AMD18894.1 - 0.0033 16.5 1.1 0.0047 16.0 0.7 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 Bunya_NS-S PF01104.12 AMD18894.1 - 0.007 15.8 0.5 0.029 13.8 0.0 2.2 2 0 0 2 2 2 1 Bunyavirus non-structural protein NS-s eIF_4G1 PF12152.3 AMD18894.1 - 0.021 14.7 0.1 0.051 13.4 0.1 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4G1 Folliculin PF11704.3 AMD18895.1 - 1.3e-49 167.9 0.1 1.6e-49 167.7 0.1 1.1 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Adeno_E1B_19K PF01691.11 AMD18895.1 - 0.032 13.5 0.1 0.6 9.3 0.0 2.2 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen Lyase_1 PF00206.15 AMD18896.1 - 1.8e-24 86.5 0.0 3.3e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 AMD18896.1 - 3.2e-17 62.2 0.2 1.5e-16 60.1 0.0 2.3 3 0 0 3 3 3 1 Adenylosuccinate lyase C-terminus AsiA PF09010.5 AMD18896.1 - 0.013 15.4 0.0 0.039 13.8 0.0 1.8 1 0 0 1 1 1 0 Anti-Sigma Factor A DUF1331 PF07048.6 AMD18896.1 - 0.054 12.9 0.1 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) Bromodomain PF00439.20 AMD18897.1 - 8.3e-32 108.9 4.5 2.6e-16 59.2 0.2 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.13 AMD18897.1 - 1.3e-21 76.5 0.3 3.4e-21 75.2 0.2 1.8 1 0 0 1 1 1 1 BAH domain SIR2 PF02146.12 AMD18898.1 - 6.8e-36 123.6 0.0 1.3e-34 119.4 0.0 2.2 1 1 0 1 1 1 1 Sir2 family AA_permease_2 PF13520.1 AMD18899.1 - 6.6e-84 281.8 41.7 8.3e-84 281.5 28.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AMD18899.1 - 3.6e-22 78.3 33.4 3.6e-22 78.3 23.1 1.4 2 0 0 2 2 2 1 Amino acid permease PAP_central PF04928.12 AMD18900.1 - 2.1e-108 360.9 0.0 3.8e-108 360.1 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 AMD18900.1 - 6.6e-47 158.9 2.3 1.2e-46 158.1 1.6 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 AMD18900.1 - 3.4e-11 43.3 0.0 9e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Peptidase_S49 PF01343.13 AMD18900.1 - 0.016 15.0 0.1 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 MACPF PF01823.14 AMD18900.1 - 0.039 13.6 2.0 0.082 12.5 1.3 1.7 1 1 0 1 1 1 0 MAC/Perforin domain Dynamin_M PF01031.15 AMD18901.1 - 1.3e-102 342.5 0.1 3.2e-102 341.3 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 AMD18901.1 - 8e-58 194.9 0.9 3.4e-57 192.9 0.1 2.3 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 AMD18901.1 - 5.9e-27 93.4 3.0 5.9e-27 93.4 2.1 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 AMD18901.1 - 0.0013 18.6 0.5 0.019 14.9 0.4 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 AMD18901.1 - 0.035 14.5 0.0 0.11 13.0 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein HTH_9 PF08221.6 AMD18901.1 - 0.046 13.5 0.4 0.45 10.4 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain APS_kinase PF01583.15 AMD18902.1 - 1.2e-69 232.9 0.0 1.5e-69 232.6 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_17 PF13207.1 AMD18902.1 - 1.5e-05 25.8 0.0 1.9e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AMD18902.1 - 0.00047 20.0 0.0 0.001 18.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD18902.1 - 0.00047 20.4 0.1 0.00094 19.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 AMD18902.1 - 0.00087 18.7 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain KTI12 PF08433.5 AMD18902.1 - 0.0013 18.0 0.0 0.0016 17.6 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.1 AMD18902.1 - 0.012 15.5 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 AMD18902.1 - 0.056 13.7 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter PRK PF00485.13 AMD18902.1 - 0.058 12.9 0.0 0.097 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family CPT PF07931.7 AMD18902.1 - 0.06 12.9 0.2 0.27 10.8 0.1 2.2 3 1 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein Snf7 PF03357.16 AMD18903.1 - 1.8e-30 105.5 17.0 1.8e-30 105.5 11.8 1.8 2 0 0 2 2 2 1 Snf7 Ist1 PF03398.9 AMD18903.1 - 1.4e-07 31.0 6.7 2.1e-07 30.5 4.7 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DASH_Dad1 PF08649.5 AMD18903.1 - 0.074 12.7 2.7 0.14 11.8 0.1 2.7 3 0 0 3 3 3 0 DASH complex subunit Dad1 DUF87 PF01935.12 AMD18903.1 - 0.076 12.8 0.1 0.076 12.8 0.1 2.1 1 1 0 2 2 2 0 Domain of unknown function DUF87 Hpt PF01627.18 AMD18903.1 - 0.13 12.2 1.1 0.31 11.0 0.1 2.1 2 0 0 2 2 2 0 Hpt domain WGG PF10273.4 AMD18903.1 - 0.14 12.2 1.2 0.35 10.9 0.3 2.1 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 BCL_N PF04714.8 AMD18903.1 - 1.8 8.2 4.7 0.51 9.9 0.1 2.5 2 0 0 2 2 2 0 BCL7, N-terminal conserver region KAT11 PF08214.6 AMD18903.1 - 1.8 7.5 8.2 0.5 9.3 0.5 2.0 2 0 0 2 2 2 0 Histone acetylation protein Ribosomal_S6 PF01250.12 AMD18904.1 - 4e-10 39.3 0.1 5.5e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 DUF1433 PF07252.6 AMD18904.1 - 0.023 14.9 0.0 0.06 13.5 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1433) PHB_depo_C PF06850.6 AMD18904.1 - 0.11 11.7 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 PHB de-polymerase C-terminus PAP2 PF01569.16 AMD18905.1 - 4.1e-12 45.8 8.5 4.1e-12 45.8 5.9 2.4 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 AMD18905.1 - 1.1e-05 25.0 6.9 1.1e-05 25.0 4.8 2.1 1 1 0 2 2 2 1 PAP2 superfamily COX8 PF02285.10 AMD18905.1 - 6.8 6.3 7.3 1.7 8.2 0.9 2.4 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIII Ribosomal_L14e PF01929.12 AMD18906.1 - 1.7e-30 105.1 0.2 2.4e-30 104.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 AMD18906.1 - 1.2e-05 24.8 0.2 2.4e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 KOW motif Reo_P9 PF06043.6 AMD18907.1 - 0.055 12.5 0.2 0.061 12.3 0.2 1.0 1 0 0 1 1 1 0 Reovirus P9-like family F-actin_cap_A PF01267.12 AMD18908.1 - 5.3e-71 238.8 1.1 6.1e-71 238.6 0.7 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit VHS PF00790.14 AMD18909.1 - 5.9e-32 110.2 3.1 8.5e-32 109.7 0.4 2.5 3 0 0 3 3 3 1 VHS domain SH3_1 PF00018.23 AMD18909.1 - 5.7e-15 54.4 0.0 1.2e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 AMD18909.1 - 5.8e-15 54.6 0.4 1.1e-14 53.6 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 AMD18909.1 - 1.6e-13 49.9 0.2 4.1e-13 48.5 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain TRAM_LAG1_CLN8 PF03798.11 AMD18910.1 - 1.3e-36 126.0 23.5 1.3e-36 126.0 16.3 2.7 2 1 1 3 3 3 1 TLC domain TRAM1 PF08390.6 AMD18910.1 - 7.4e-24 83.0 0.4 1.8e-23 81.7 0.3 1.7 1 0 0 1 1 1 1 TRAM1-like protein Herpes_LMP1 PF05297.6 AMD18910.1 - 1.2 7.9 5.2 1.8 7.3 3.6 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Ribosomal_S2 PF00318.15 AMD18911.1 - 1.2e-58 197.7 0.0 2.5e-58 196.7 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S2 Ribosomal_L10 PF00466.15 AMD18913.1 - 2.7e-17 62.5 0.0 4.1e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 HECT PF00632.20 AMD18914.1 - 6.3e-74 248.9 0.0 1.2e-73 248.0 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.20 AMD18915.1 - 2.2e-72 243.3 0.0 3.9e-72 242.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18915.1 - 1.5e-46 158.5 0.0 2.7e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 AMD18915.1 - 1.4e-22 79.8 0.2 5.7e-22 77.8 0.1 2.3 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.1 AMD18915.1 - 5.7e-06 25.4 0.0 1.1e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD18915.1 - 0.36 10.5 3.3 0.42 10.2 0.0 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF1777 PF08648.7 AMD18915.1 - 0.48 10.1 24.8 0.027 14.1 13.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) CAF-1_p150 PF11600.3 AMD18915.1 - 0.55 9.5 35.9 0.24 10.7 17.4 2.9 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CDC45 PF02724.9 AMD18915.1 - 1 7.2 8.8 1.8 6.4 6.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Ycf1 PF05758.7 AMD18915.1 - 7.4 4.1 11.5 1.2 6.7 4.1 1.9 2 0 0 2 2 2 0 Ycf1 CENP-C_C PF11699.3 AMD18916.1 - 7.5e-28 96.3 2.4 1.6e-27 95.3 1.7 1.6 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.1 AMD18916.1 - 8.9e-19 68.4 1.0 8.9e-19 68.4 0.7 3.5 2 2 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.6 AMD18916.1 - 0.00033 20.1 0.0 0.00066 19.1 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Smr PF01713.16 AMD18917.1 - 2.2e-13 50.1 0.0 6e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Smr domain CUE PF02845.11 AMD18917.1 - 9.9e-10 37.7 0.3 2.9e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 CUE domain HNH PF01844.18 AMD18918.1 - 0.011 15.5 2.4 0.031 14.1 1.7 1.8 1 0 0 1 1 1 0 HNH endonuclease Aminotran_1_2 PF00155.16 AMD18919.1 - 8.5e-40 136.8 0.0 1.7e-39 135.8 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 AMD18919.1 - 0.075 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase DnaJ PF00226.26 AMD18920.1 - 4.9e-26 90.2 2.3 8e-26 89.5 1.6 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 AMD18920.1 - 4.1e-19 68.2 0.0 2.6e-16 59.2 0.0 2.5 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 AMD18920.1 - 6.5e-12 45.3 9.8 1.6e-11 44.0 6.9 1.6 1 1 0 1 1 1 1 DnaJ central domain zinc_ribbon_6 PF14599.1 AMD18920.1 - 0.076 12.8 4.6 2 8.2 1.4 2.6 2 0 0 2 2 2 0 Zinc-ribbon GCC2_GCC3 PF07699.8 AMD18920.1 - 3.4 7.3 11.8 0.12 11.9 2.6 2.5 2 1 1 3 3 3 0 GCC2 and GCC3 Securin PF04856.8 AMD18921.1 - 8.1e-21 74.8 17.1 2.8e-20 73.0 11.9 1.8 1 1 0 1 1 1 1 Securin sister-chromatid separation inhibitor Ribosomal_L34 PF00468.12 AMD18923.1 - 5.4e-18 64.4 6.8 5.4e-18 64.4 4.7 1.6 1 1 0 1 1 1 1 Ribosomal protein L34 Ribosomal_L1 PF00687.16 AMD18924.1 - 1.1e-26 93.5 0.5 1.5e-26 93.1 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family SUI1 PF01253.17 AMD18925.1 - 2.6e-15 55.9 0.1 1.1e-14 53.9 0.1 2.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 SWIB PF02201.13 AMD18925.1 - 0.013 15.1 0.0 0.042 13.5 0.0 1.8 1 0 0 1 1 1 0 SWIB/MDM2 domain Apc4 PF12896.2 AMD18926.1 - 1.1e-30 106.5 5.8 1.8e-30 105.8 4.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 Sulfate_transp PF00916.15 AMD18927.1 - 2.8e-77 259.4 6.2 2.8e-77 259.4 4.3 2.0 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 AMD18927.1 - 1.4e-31 107.9 4.4 1.4e-31 107.9 3.0 3.1 4 0 0 4 4 4 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 AMD18927.1 - 0.00018 20.9 0.0 0.00039 19.8 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 AMD18927.1 - 0.025 14.5 0.0 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 STAS domain MFS_1 PF07690.11 AMD18928.1 - 1.3e-10 40.5 37.2 2.2e-09 36.4 22.5 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRM PF02005.11 AMD18930.1 - 8e-137 456.1 0.0 1e-136 455.8 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.11 AMD18930.1 - 0.0016 18.0 0.1 0.003 17.1 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein zf-C4_ClpX PF06689.8 AMD18930.1 - 0.012 15.1 0.1 0.047 13.1 0.0 2.0 2 0 0 2 2 2 0 ClpX C4-type zinc finger Cons_hypoth95 PF03602.10 AMD18930.1 - 0.037 13.4 0.0 0.085 12.2 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.9 AMD18930.1 - 0.099 12.0 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain CBFD_NFYB_HMF PF00808.18 AMD18931.1 - 0.00014 21.8 0.1 0.00034 20.6 0.1 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Nyv1_N PF09426.5 AMD18932.1 - 1.7e-48 163.7 0.8 2.7e-48 163.1 0.6 1.3 1 0 0 1 1 1 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.16 AMD18932.1 - 2.8e-25 87.7 3.9 4.2e-25 87.1 2.7 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF2077 PF09850.4 AMD18932.1 - 0.11 11.9 0.5 0.45 9.8 0.2 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2077) FMO-like PF00743.14 AMD18933.1 - 6.3e-30 103.8 0.1 4.1e-18 64.8 0.2 3.2 1 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 AMD18933.1 - 3.3e-18 66.4 0.0 7.5e-17 62.0 0.0 2.5 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 AMD18933.1 - 2e-11 43.4 0.0 7.9e-09 34.8 0.0 2.6 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 AMD18933.1 - 1.1e-10 41.5 0.0 1.4e-09 37.9 0.0 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 AMD18933.1 - 4e-10 39.9 0.0 2e-09 37.6 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 AMD18933.1 - 2.8e-05 24.0 0.0 7.7e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 AMD18933.1 - 7.7e-05 23.0 0.1 0.013 15.8 0.0 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 AMD18933.1 - 0.023 13.7 0.0 0.17 10.9 0.0 2.0 2 0 0 2 2 2 0 Thi4 family F420_oxidored PF03807.12 AMD18933.1 - 0.055 13.8 0.0 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 AMD18933.1 - 0.081 13.0 0.0 0.25 11.4 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.18 AMD18933.1 - 0.096 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DAO PF01266.19 AMD18933.1 - 0.1 11.4 0.0 0.45 9.3 0.0 2.1 3 0 0 3 3 3 0 FAD dependent oxidoreductase Semialdhyde_dh PF01118.19 AMD18933.1 - 0.13 12.5 0.0 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain PHD PF00628.24 AMD18935.1 - 0.0031 17.1 1.8 0.0031 17.1 1.2 2.3 3 0 0 3 3 3 1 PHD-finger zf-CSL PF05207.8 AMD18935.1 - 0.037 13.5 2.2 0.1 12.1 1.6 1.7 1 0 0 1 1 1 0 CSL zinc finger Pkinase PF00069.20 AMD18936.1 - 2.9e-72 242.9 2.3 2.5e-71 239.8 1.6 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18936.1 - 1.2e-40 139.2 1.0 8.5e-39 133.1 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase KA1 PF02149.14 AMD18936.1 - 9.5e-20 69.7 0.0 1.8e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.1 AMD18936.1 - 3.8e-06 26.0 0.0 5.9e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD18936.1 - 0.0001 21.4 0.0 0.00022 20.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD18936.1 - 0.0025 17.5 0.0 0.059 13.0 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 AMD18936.1 - 0.024 13.8 0.2 0.049 12.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 AMD18936.1 - 0.063 12.6 1.5 0.3 10.4 0.0 2.4 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL DUF2841 PF11001.3 AMD18938.1 - 7.2e-38 129.2 1.0 1.5e-37 128.2 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) Fungal_trans PF04082.13 AMD18939.1 - 4.9e-36 123.9 0.7 1.1e-35 122.7 0.5 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD18939.1 - 2.1e-09 37.1 11.5 3.4e-09 36.4 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-DHHC PF01529.15 AMD18941.1 - 2.4e-25 88.9 14.0 2.4e-25 88.9 9.7 2.7 2 1 0 2 2 2 1 DHHC palmitoyltransferase EPSP_synthase PF00275.15 AMD18942.1 - 1.2e-131 439.0 0.0 1.6e-131 438.6 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 AMD18942.1 - 1.5e-100 335.4 0.0 2.5e-100 334.7 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.10 AMD18942.1 - 8.1e-64 215.3 0.0 1.9e-63 214.1 0.0 1.7 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 AMD18942.1 - 1.2e-36 125.9 0.1 2.3e-35 121.7 0.0 2.4 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.6 AMD18942.1 - 1.7e-21 76.0 0.0 7.1e-21 74.0 0.0 2.1 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 AMD18942.1 - 1.3e-15 57.6 0.0 3.8e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.1 AMD18942.1 - 1.1e-08 34.7 0.0 2.2e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_17 PF13207.1 AMD18942.1 - 0.00033 21.4 0.0 0.001 19.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AMD18942.1 - 0.001 18.9 0.0 0.0032 17.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AMD18942.1 - 0.091 12.6 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain WD40 PF00400.27 AMD18943.1 - 4.2e-11 42.2 21.4 6.6e-05 22.6 0.1 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat RWD PF05773.17 AMD18943.1 - 0.0033 17.3 0.0 0.01 15.7 0.0 1.8 1 0 0 1 1 1 1 RWD domain zf-rbx1 PF12678.2 AMD18943.1 - 0.016 15.3 7.7 0.053 13.6 5.4 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_2 PF13639.1 AMD18943.1 - 0.041 13.7 7.0 0.12 12.2 4.8 1.8 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 AMD18943.1 - 0.35 10.9 14.2 0.17 11.9 7.7 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CH PF00307.26 AMD18945.1 - 8.9e-67 221.9 0.0 5.5e-19 68.1 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.1 AMD18945.1 - 1.9e-05 24.7 0.8 8.5e-05 22.6 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.3 AMD18945.1 - 0.00014 21.4 0.0 0.66 9.6 0.0 3.9 4 0 0 4 4 4 1 CAMSAP CH domain EF-hand_1 PF00036.27 AMD18945.1 - 0.00074 18.6 1.8 0.87 9.0 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 AMD18945.1 - 0.056 13.3 1.5 0.43 10.6 0.1 3.0 2 1 0 2 2 2 0 EF-hand domain Apc9 PF12856.2 AMD18946.1 - 5e-13 48.9 0.0 9.8e-13 48.0 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 CDC45 PF02724.9 AMD18947.1 - 1.8e-196 653.9 0.0 2e-196 653.7 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF3847 PF12958.2 AMD18947.1 - 0.054 13.2 0.0 1.7 8.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) DUF2933 PF11666.3 AMD18948.1 - 0.0064 16.0 0.4 0.0094 15.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2933) tRNA_int_endo PF01974.12 AMD18949.1 - 2.4e-23 81.7 0.0 5.1e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 AMD18949.1 - 0.091 12.3 0.1 0.79 9.3 0.1 2.2 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain AAA_5 PF07728.9 AMD18950.1 - 4.4e-129 424.9 0.5 1.8e-21 76.3 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA PF00004.24 AMD18950.1 - 1.8e-30 105.8 1.8 2.8e-05 24.3 0.0 7.7 7 0 0 7 7 6 6 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.6 AMD18950.1 - 3.3e-30 104.3 0.0 1.2e-10 41.0 0.0 7.5 7 0 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 AMD18950.1 - 2.5e-21 75.8 0.9 0.0012 18.7 0.0 7.9 8 0 0 8 8 7 4 AAA domain AAA_17 PF13207.1 AMD18950.1 - 1e-20 74.7 22.9 0.00063 20.5 0.0 9.6 8 1 0 8 8 6 5 AAA domain Sigma54_activ_2 PF14532.1 AMD18950.1 - 1.2e-20 74.0 1.7 0.0015 18.5 0.0 7.6 7 0 0 7 7 7 3 Sigma-54 interaction domain AAA_22 PF13401.1 AMD18950.1 - 1.9e-20 73.3 7.3 0.00029 21.0 0.0 7.9 8 0 0 8 8 7 5 AAA domain AAA_16 PF13191.1 AMD18950.1 - 1.3e-18 67.6 6.0 0.0073 16.3 0.0 8.2 7 1 0 7 7 7 4 AAA ATPase domain Sigma54_activat PF00158.21 AMD18950.1 - 4.3e-18 65.3 0.4 0.0081 15.6 0.1 6.6 6 0 0 6 6 6 4 Sigma-54 interaction domain AAA_33 PF13671.1 AMD18950.1 - 1.1e-16 61.0 0.0 0.032 14.1 0.0 7.0 6 0 0 6 6 6 3 AAA domain ABC_tran PF00005.22 AMD18950.1 - 1.1e-15 58.1 12.6 0.00084 19.6 0.0 7.7 7 0 0 7 7 6 3 ABC transporter Zeta_toxin PF06414.7 AMD18950.1 - 2.8e-15 55.9 4.5 0.54 9.3 0.0 8.5 9 0 0 9 9 8 5 Zeta toxin AAA_19 PF13245.1 AMD18950.1 - 1.4e-14 53.5 4.9 0.032 13.9 0.0 6.4 6 0 0 6 6 6 4 Part of AAA domain T2SE PF00437.15 AMD18950.1 - 4.2e-14 52.1 5.3 0.029 13.2 0.2 6.3 6 0 0 6 6 6 4 Type II/IV secretion system protein AAA_30 PF13604.1 AMD18950.1 - 2.8e-13 49.8 7.1 0.019 14.5 0.0 7.9 8 0 0 8 8 7 2 AAA domain Miro PF08477.8 AMD18950.1 - 6.8e-12 45.9 6.1 0.57 10.6 0.1 7.6 7 0 0 7 7 7 1 Miro-like protein RNA_helicase PF00910.17 AMD18950.1 - 1.1e-11 44.8 8.4 1.2 9.2 0.0 8.6 8 0 0 8 8 8 3 RNA helicase MobB PF03205.9 AMD18950.1 - 1.3e-11 44.3 6.0 0.34 10.5 0.2 6.7 6 0 0 6 6 6 3 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 AMD18950.1 - 4.5e-11 42.2 7.4 0.18 10.9 0.1 6.0 6 0 0 6 6 6 4 Protein of unknown function, DUF258 UPF0079 PF02367.12 AMD18950.1 - 9.7e-11 41.3 2.2 0.22 11.1 0.0 6.3 6 0 0 6 6 6 3 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 AMD18950.1 - 1.7e-10 40.3 1.5 0.77 9.3 0.0 6.4 6 0 0 6 6 6 2 P-loop containing region of AAA domain SRP54 PF00448.17 AMD18950.1 - 7e-10 38.6 6.4 0.087 12.2 0.0 6.8 7 0 0 7 7 7 2 SRP54-type protein, GTPase domain Mg_chelatase PF01078.16 AMD18950.1 - 7.5e-10 38.3 2.3 4.1 6.5 0.0 8.3 8 1 1 9 9 9 1 Magnesium chelatase, subunit ChlI NACHT PF05729.7 AMD18950.1 - 7.9e-10 38.6 5.2 0.43 10.2 0.1 6.3 5 0 0 5 5 5 3 NACHT domain PduV-EutP PF10662.4 AMD18950.1 - 9.3e-10 38.1 3.8 0.035 13.5 0.0 5.8 6 0 0 6 6 6 3 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.12 AMD18950.1 - 5.5e-09 35.6 0.4 0.14 11.5 0.0 5.8 6 0 0 6 6 6 2 IstB-like ATP binding protein RuvB_N PF05496.7 AMD18950.1 - 1.4e-08 34.0 1.9 0.14 11.1 0.0 5.2 5 0 0 5 5 5 3 Holliday junction DNA helicase ruvB N-terminus PhoH PF02562.11 AMD18950.1 - 1.9e-08 33.7 3.0 0.61 9.2 0.0 5.7 5 0 0 5 5 5 2 PhoH-like protein AAA_25 PF13481.1 AMD18950.1 - 7e-08 32.1 2.6 1.9 7.8 0.0 5.7 6 0 0 6 6 5 2 AAA domain AAA_28 PF13521.1 AMD18950.1 - 7.4e-08 32.5 16.4 0.39 10.6 0.0 8.2 8 0 0 8 8 8 1 AAA domain MMR_HSR1 PF01926.18 AMD18950.1 - 1.7e-07 31.1 1.8 3.5 7.6 0.0 6.3 6 0 0 6 6 5 1 50S ribosome-binding GTPase ATP-synt_ab PF00006.20 AMD18950.1 - 2.4e-07 30.4 0.0 0.13 11.7 0.0 4.7 3 1 0 3 3 3 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.1 AMD18950.1 - 8.6e-06 26.0 52.4 0.0081 16.4 0.0 10.3 10 1 0 10 10 6 5 AAA domain FtsK_SpoIIIE PF01580.13 AMD18950.1 - 0.00037 20.0 2.4 3.6 7.0 0.1 5.0 5 0 0 5 5 4 1 FtsK/SpoIIIE family NTPase_1 PF03266.10 AMD18950.1 - 0.0017 18.0 13.6 1.8 8.2 0.2 6.8 7 0 0 7 7 6 1 NTPase RNase_T PF00929.19 AMD18951.1 - 8.1e-16 58.7 0.0 2.3e-15 57.2 0.0 1.8 1 0 0 1 1 1 1 Exonuclease CHORD PF04968.7 AMD18951.1 - 0.14 12.3 2.7 0.32 11.2 1.9 1.5 1 0 0 1 1 1 0 CHORD BTB_2 PF02214.17 AMD18953.1 - 1.7e-07 31.3 0.1 0.00031 20.8 0.1 2.6 2 1 0 2 2 2 2 BTB/POZ domain Redoxin PF08534.5 AMD18954.1 - 5e-31 107.2 0.1 5.9e-31 106.9 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 AMD18954.1 - 4.4e-11 42.5 0.0 5.4e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Hydrolase PF00702.21 AMD18954.1 - 0.023 15.0 0.0 0.024 15.0 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Flocculin_t3 PF13928.1 AMD18955.1 - 8.2e-13 48.2 16.8 8.2e-13 48.2 11.7 1.9 2 0 0 2 2 2 1 Flocculin type 3 repeat Pkinase PF00069.20 AMD18956.1 - 5.8e-70 235.3 0.2 1.2e-69 234.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD18956.1 - 1.2e-31 109.7 0.0 2.4e-31 108.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 AMD18956.1 - 3.5e-05 22.9 0.1 0.00015 20.9 0.1 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD18956.1 - 0.00029 20.6 4.0 0.0015 18.3 0.0 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 AMD18956.1 - 0.00038 19.5 2.0 0.061 12.2 0.0 3.1 2 1 0 3 3 3 1 Kinase-like RIO1 PF01163.17 AMD18956.1 - 0.031 13.6 0.4 0.078 12.3 0.0 1.8 2 0 0 2 2 2 0 RIO1 family ABC_membrane PF00664.18 AMD18957.1 - 1.3e-87 293.7 45.8 5.2e-50 170.4 6.7 2.9 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 AMD18957.1 - 1.5e-48 164.5 0.0 6e-28 97.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 AMD18957.1 - 1.4e-09 37.4 3.5 0.00067 18.9 0.1 4.1 2 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 AMD18957.1 - 6.1e-09 36.1 1.2 0.0015 18.5 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_10 PF12846.2 AMD18957.1 - 2.4e-06 27.2 1.4 0.44 9.9 0.2 3.5 2 1 1 3 3 3 2 AAA-like domain AAA_25 PF13481.1 AMD18957.1 - 5.6e-06 25.8 0.0 0.047 13.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 AMD18957.1 - 1.9e-05 24.5 0.0 0.11 12.5 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.1 AMD18957.1 - 2.6e-05 23.6 0.1 0.1 12.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 AMD18957.1 - 0.00014 22.2 0.2 0.35 11.1 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_21 PF13304.1 AMD18957.1 - 0.00044 20.3 6.1 2.7 7.8 0.0 5.6 5 1 1 6 6 6 2 AAA domain Miro PF08477.8 AMD18957.1 - 0.001 19.5 2.3 0.77 10.2 0.1 3.0 3 0 0 3 3 2 2 Miro-like protein TrwB_AAD_bind PF10412.4 AMD18957.1 - 0.0014 17.3 0.3 0.16 10.5 0.0 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain DUF258 PF03193.11 AMD18957.1 - 0.0014 17.8 0.0 0.68 9.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 AMD18957.1 - 0.0015 17.5 0.0 0.19 10.5 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein Dynamin_N PF00350.18 AMD18957.1 - 0.0025 17.6 0.3 0.17 11.7 0.0 2.8 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.12 AMD18957.1 - 0.0028 17.5 6.4 0.14 11.9 0.0 3.0 3 0 0 3 3 2 2 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 AMD18957.1 - 0.007 15.8 0.0 1.5 8.2 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_30 PF13604.1 AMD18957.1 - 0.015 14.8 0.2 18 4.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 AMD18957.1 - 0.031 14.4 1.3 2.4 8.3 0.1 2.9 2 1 0 2 2 2 0 AAA domain MobB PF03205.9 AMD18957.1 - 0.04 13.6 0.7 10 5.8 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 AMD18957.1 - 0.04 13.0 0.2 7.8 5.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.1 AMD18957.1 - 0.094 13.5 0.1 6.3 7.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 AMD18957.1 - 0.13 11.9 3.1 2.6 7.6 0.1 3.6 4 0 0 4 4 4 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 AMD18957.1 - 0.28 10.8 1.8 0.79 9.3 0.1 2.4 2 0 0 2 2 2 0 NACHT domain NESP55 PF06390.7 AMD18957.1 - 2 7.7 5.3 0.39 10.0 1.2 1.6 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) ENTH PF01417.15 AMD18958.1 - 9.7e-30 103.0 0.4 1.8e-29 102.1 0.3 1.5 1 0 0 1 1 1 1 ENTH domain RWD PF05773.17 AMD18959.1 - 9.5e-20 70.5 1.7 1.7e-19 69.7 1.2 1.4 1 0 0 1 1 1 1 RWD domain zf-CCCH PF00642.19 AMD18960.1 - 4.9e-21 73.9 18.3 5.5e-11 41.8 1.9 2.2 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 AMD18960.1 - 0.06 13.3 11.5 0.57 10.2 0.6 2.6 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type Mcp5_PH PF12814.2 AMD18961.1 - 5.4e-38 129.6 0.0 1.3e-37 128.4 0.0 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Pyr_redox PF00070.22 AMD18961.1 - 0.31 11.4 1.0 30 5.0 0.0 4.3 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase DUF972 PF06156.8 AMD18961.1 - 1 9.7 26.1 0.035 14.4 3.8 4.8 3 1 1 4 4 4 0 Protein of unknown function (DUF972) Slx4 PF09494.5 AMD18962.1 - 4.7e-11 42.2 0.1 1.5e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 Slx4 endonuclease Pox_L3_FP4 PF03339.9 AMD18962.1 - 0.028 12.9 0.5 0.048 12.1 0.3 1.3 1 0 0 1 1 1 0 Poxvirus L3/FP4 protein DUF2743 PF10899.3 AMD18962.1 - 0.081 12.2 2.5 0.23 10.7 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2743) Tnp_DNA_bind PF14706.1 AMD18962.1 - 0.13 12.0 0.1 0.66 9.7 0.0 2.3 2 0 0 2 2 2 0 Transposase DNA-binding Eno-Rase_FAD_bd PF07055.7 AMD18962.1 - 2.6 8.0 8.3 2 8.4 0.2 4.2 6 0 0 6 6 6 0 Enoyl reductase FAD binding domain DUF2203 PF09969.4 AMD18962.1 - 8.2 6.6 7.6 3.1 8.0 0.6 3.2 2 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) 2-oxoacid_dh PF00198.18 AMD18963.1 - 2.3e-79 265.9 0.1 3e-79 265.5 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 AMD18963.1 - 4.3e-16 58.3 0.5 7.6e-16 57.5 0.3 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 AMD18963.1 - 5.6e-05 22.7 0.7 0.00091 18.8 0.2 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.14 AMD18963.1 - 0.00013 21.6 0.1 0.00028 20.5 0.1 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein HlyD_3 PF13437.1 AMD18963.1 - 0.00054 20.2 0.3 0.0047 17.2 0.1 2.3 1 1 1 2 2 2 1 HlyD family secretion protein RnfC_N PF13375.1 AMD18963.1 - 0.001 18.7 0.1 0.0045 16.6 0.0 2.1 1 1 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Choline_kinase PF01633.15 AMD18964.1 - 1.9e-61 207.3 0.0 2.6e-61 206.8 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 AMD18964.1 - 5.5e-13 48.1 0.1 5.5e-13 48.1 0.1 2.4 4 0 0 4 4 4 1 Choline kinase N terminus APH PF01636.18 AMD18964.1 - 3.8e-09 36.6 0.0 0.00032 20.5 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family HVSL PF09749.4 AMD18965.1 - 9.8e-13 47.6 0.1 1.4e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein AKAP7_NLS PF10469.4 AMD18965.1 - 0.14 11.8 0.6 0.68 9.5 0.1 2.1 2 1 0 2 2 2 0 AKAP7 2'5' RNA ligase-like domain zf-C2H2 PF00096.21 AMD18966.1 - 2.8e-08 33.6 15.1 0.0045 17.2 1.3 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD18966.1 - 7.1e-06 25.9 11.4 0.062 13.6 0.6 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD18966.1 - 0.00032 20.8 12.1 0.002 18.2 0.1 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 AMD18966.1 - 0.72 9.8 7.5 1.5 8.8 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger WD40 PF00400.27 AMD18967.1 - 2.9e-70 229.8 27.1 5.9e-10 38.6 0.0 12.2 12 0 0 12 12 12 10 WD domain, G-beta repeat Utp12 PF04003.7 AMD18967.1 - 4.6e-19 68.3 0.2 9.7e-19 67.3 0.1 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 AMD18967.1 - 3e-06 25.6 10.7 0.042 11.9 0.3 5.7 4 3 1 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.6 AMD18967.1 - 2.2e-05 24.2 7.3 1.2 8.7 0.0 5.5 2 2 3 5 5 5 3 Eukaryotic translation initiation factor eIF2A Hira PF07569.6 AMD18967.1 - 2.2 7.4 12.6 10 5.2 0.0 4.6 4 1 1 5 5 5 0 TUP1-like enhancer of split TFIID_20kDa PF03847.8 AMD18968.1 - 3.3e-32 110.5 0.6 3.3e-32 110.5 0.4 1.7 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.19 AMD18968.1 - 0.002 18.1 0.0 0.0047 17.0 0.0 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 AMD18968.1 - 0.066 13.2 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Cullin_binding PF03556.10 AMD18969.1 - 5e-31 107.2 5.6 5e-31 107.2 3.9 1.8 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.1 AMD18969.1 - 3.5e-10 39.2 0.1 9.1e-10 37.9 0.1 1.8 1 0 0 1 1 1 1 UBA-like domain Cullin PF00888.17 AMD18970.1 - 4e-17 61.9 5.7 9.8e-17 60.7 4.0 1.6 1 0 0 1 1 1 1 Cullin family Pro_isomerase PF00160.16 AMD18971.1 - 4.6e-48 163.3 0.1 5.2e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.1 AMD18971.1 - 0.049 13.4 0.1 0.39 10.5 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin domain Rgp1 PF08737.5 AMD18972.1 - 6e-67 226.5 7.0 1e-66 225.7 4.9 1.3 1 0 0 1 1 1 1 Rgp1 Arrestin_C PF02752.17 AMD18972.1 - 0.00093 19.3 3.8 0.4 10.7 0.4 3.4 2 2 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Avl9 PF09794.4 AMD18973.1 - 5.8e-147 489.1 3.1 7.6e-147 488.7 2.2 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.4 AMD18973.1 - 7.4e-10 38.5 2.2 1.1e-08 34.7 1.5 2.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.5 AMD18973.1 - 1.4e-08 34.4 0.2 5.7e-05 22.7 0.0 3.0 3 0 0 3 3 3 2 Stabilization of polarity axis DENN PF02141.16 AMD18973.1 - 0.0044 16.7 1.9 1.4 8.6 0.2 2.7 2 1 1 3 3 3 2 DENN (AEX-3) domain Afi1 PF07792.7 AMD18973.1 - 0.012 15.6 0.1 0.041 13.8 0.1 1.9 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking efThoc1 PF11957.3 AMD18974.1 - 1.5e-62 211.7 16.3 2.2e-62 211.1 11.3 1.3 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor CPSF100_C PF13299.1 AMD18975.1 - 3.4e-29 102.1 0.6 1.5e-26 93.5 0.4 2.8 1 1 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 AMD18975.1 - 4.7e-12 45.9 0.0 1.2e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain KH_3 PF13014.1 AMD18976.1 - 2.8e-06 26.8 0.2 9.6e-06 25.1 0.1 2.0 1 0 0 1 1 1 1 KH domain KH_1 PF00013.24 AMD18976.1 - 1.9e-05 24.2 0.0 3.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.18 AMD18976.1 - 0.00036 20.3 10.3 0.014 15.3 0.6 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.1 AMD18976.1 - 0.0017 18.0 1.0 0.49 10.1 0.0 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 AMD18976.1 - 0.013 15.1 3.1 1.4 8.6 0.2 2.5 2 0 0 2 2 2 0 Zinc knuckle UPF0167 PF03691.9 AMD18976.1 - 0.049 13.0 0.1 0.077 12.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) PolC_DP2 PF03833.8 AMD18976.1 - 0.19 9.3 0.1 0.24 9.0 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 TPR_16 PF13432.1 AMD18977.1 - 2.8e-11 43.7 3.5 0.011 16.4 0.2 5.7 6 1 1 7 7 7 3 Tetratricopeptide repeat Suf PF05843.9 AMD18977.1 - 6.1e-11 42.5 14.6 0.0075 16.0 0.1 6.2 3 2 1 4 4 4 4 Suppressor of forked protein (Suf) TPR_14 PF13428.1 AMD18977.1 - 6.2e-11 41.9 1.8 0.74 10.6 0.1 7.5 4 2 4 8 8 8 3 Tetratricopeptide repeat HAT PF02184.11 AMD18977.1 - 1.8e-07 30.7 41.8 0.0041 16.8 1.0 9.8 10 1 0 10 10 10 5 HAT (Half-A-TPR) repeat TPR_19 PF14559.1 AMD18977.1 - 2e-06 28.0 2.1 0.25 11.7 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 AMD18977.1 - 1.3e-05 25.0 8.4 4.6 7.2 0.3 5.7 5 1 0 5 5 5 2 Tetratricopeptide repeat U3_assoc_6 PF08640.6 AMD18977.1 - 0.0016 18.1 17.0 0.0028 17.3 1.0 5.5 4 1 1 5 5 5 1 U3 small nucleolar RNA-associated protein 6 TPR_15 PF13429.1 AMD18977.1 - 0.0018 17.3 10.1 0.0063 15.6 0.0 3.3 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 AMD18977.1 - 0.034 14.0 20.1 17 5.5 0.1 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat YfdX PF10938.3 AMD18977.1 - 0.036 13.7 0.0 48 3.5 0.0 3.3 3 0 0 3 3 3 0 YfdX protein TPR_17 PF13431.1 AMD18977.1 - 0.077 13.2 0.1 0.94 9.8 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4398 PF14346.1 AMD18977.1 - 0.15 12.1 0.8 0.54 10.3 0.5 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4398) TPR_8 PF13181.1 AMD18977.1 - 3.6 7.5 7.6 28 4.8 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ubiquitin PF00240.18 AMD18978.1 - 8.4e-22 76.3 0.1 9.3e-22 76.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 AMD18978.1 - 9.2e-15 54.0 0.0 1e-14 53.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 AMD18978.1 - 0.0041 17.3 0.0 0.011 15.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 AMD18978.1 - 0.07 13.0 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Methyltransf_26 PF13659.1 AMD18979.1 - 7.6e-10 38.8 0.0 1.2e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AMD18979.1 - 1.2e-06 28.0 0.0 1.3e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 AMD18979.1 - 1.2e-05 24.9 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 AMD18979.1 - 0.015 14.3 0.0 0.028 13.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 AMD18979.1 - 0.071 13.6 0.0 0.19 12.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.1 AMD18979.1 - 0.1 12.3 0.0 0.49 10.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Dopey_N PF04118.9 AMD18980.1 - 4.7e-117 390.1 3.1 4.7e-117 390.1 2.1 3.3 3 1 0 4 4 4 2 Dopey, N-terminal Mod_r PF07200.8 AMD18981.1 - 4.3e-18 65.6 12.1 5.3e-18 65.3 8.4 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein DUF1027 PF06265.6 AMD18981.1 - 0.044 13.6 3.9 0.079 12.8 2.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1027) Orthopox_F7 PF05813.7 AMD18981.1 - 0.16 11.8 0.7 0.3 11.0 0.0 1.8 2 0 0 2 2 2 0 Orthopoxvirus F7 protein APG6 PF04111.7 AMD18981.1 - 0.24 10.4 6.9 0.32 9.9 4.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF228 PF02989.9 AMD18981.1 - 0.26 10.8 2.8 0.28 10.7 1.1 1.7 1 1 0 1 1 1 0 Lyme disease proteins of unknown function Seryl_tRNA_N PF02403.17 AMD18981.1 - 5.7 7.0 7.6 5.1 7.1 0.3 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain WD40 PF00400.27 AMD18982.1 - 3.3e-29 99.6 13.3 1.2e-07 31.2 0.2 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat zf-RING_2 PF13639.1 AMD18983.1 - 8.7e-13 47.8 6.2 2.8e-11 43.0 1.5 2.3 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.2 AMD18983.1 - 4.1e-07 30.0 3.3 5.9e-06 26.3 0.9 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 AMD18983.1 - 3.8e-06 26.8 7.2 7.6e-06 25.8 1.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD18983.1 - 4.2e-06 26.3 4.9 6.6e-06 25.6 1.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD18983.1 - 1.6e-05 24.4 3.5 3.2e-05 23.4 0.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 AMD18983.1 - 1.9e-05 24.2 0.2 1.9e-05 24.2 0.1 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 AMD18983.1 - 0.00019 21.2 1.6 0.00019 21.2 1.1 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 AMD18983.1 - 0.00039 20.0 5.0 0.00069 19.2 0.9 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.1 AMD18983.1 - 0.00095 18.6 0.9 0.0023 17.4 0.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Apc11 PF12861.2 AMD18983.1 - 0.02 14.6 1.2 0.042 13.6 0.3 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.3 AMD18983.1 - 0.083 12.4 0.6 0.17 11.4 0.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 AMD18983.1 - 0.4 10.3 5.0 0.75 9.4 1.1 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Asp PF00026.18 AMD18984.1 - 6.6e-72 242.4 0.1 8.4e-72 242.0 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD18984.1 - 7.2e-08 32.5 0.2 1.4e-07 31.6 0.1 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 AMD18984.1 - 0.001 18.6 0.0 0.0071 15.9 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 AMD18984.1 - 0.0041 17.5 0.1 5.4 7.5 0.0 3.7 3 0 0 3 3 3 1 Aspartyl protease Asp PF00026.18 AMD18985.1 - 7.8e-65 219.1 0.1 9.4e-65 218.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD18985.1 - 3.2e-10 40.2 0.0 5.7e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 AMD18985.1 - 0.0097 15.4 0.0 0.045 13.2 0.0 2.0 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 AMD18985.1 - 0.11 13.0 0.6 3.1 8.3 0.1 3.0 2 1 0 2 2 2 0 Aspartyl protease RNA_polI_A14 PF08203.6 AMD18986.1 - 7.8e-21 74.1 4.4 8.8e-21 73.9 0.0 2.2 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 Semialdhyde_dhC PF02774.13 AMD18987.1 - 3.6e-43 147.5 0.0 4.9e-43 147.1 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 AMD18987.1 - 6.4e-31 107.1 0.0 1.1e-30 106.3 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 AMD18987.1 - 0.023 13.6 0.1 0.069 12.1 0.0 1.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase DXP_reductoisom PF02670.11 AMD18987.1 - 0.068 13.7 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.15 AMD18987.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Methyltransf_16 PF10294.4 AMD18988.1 - 2.7e-07 30.2 0.9 0.0002 20.8 0.0 2.4 2 0 0 2 2 2 2 Putative methyltransferase RrnaAD PF00398.15 AMD18988.1 - 0.037 13.0 0.0 0.052 12.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase SAC3_GANP PF03399.11 AMD18989.1 - 2e-55 187.5 0.5 2e-55 187.5 0.3 1.9 2 0 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family SAC3 PF12209.3 AMD18989.1 - 1e-15 57.5 1.2 1e-15 57.5 0.8 2.4 2 0 0 2 2 2 1 Leucine permease transcriptional regulator helical domain Spore_III_AB PF09548.5 AMD18989.1 - 0.025 14.3 1.2 0.062 13.0 0.1 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Nha1_C PF08619.5 AMD18990.1 - 6e-83 279.5 37.1 7.3e-83 279.2 25.7 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.16 AMD18990.1 - 5.1e-76 255.6 23.6 6.1e-76 255.4 16.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Sigma70_ner PF04546.8 AMD18990.1 - 1.4 8.4 16.0 3.6 7.1 11.1 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region TPR_2 PF07719.12 AMD18991.1 - 4.2e-07 29.3 3.0 0.35 10.9 0.0 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 AMD18991.1 - 4.7e-07 29.8 0.1 2.5 8.9 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 AMD18991.1 - 9.4e-07 28.1 1.0 4.3 7.3 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 AMD18991.1 - 2.2e-06 27.2 6.1 0.02 14.5 0.0 4.0 3 1 0 3 3 3 2 TPR repeat TPR_19 PF14559.1 AMD18991.1 - 9e-06 25.9 11.1 0.0033 17.7 0.1 4.2 3 2 2 5 5 5 3 Tetratricopeptide repeat Apc3 PF12895.2 AMD18991.1 - 1.9e-05 24.7 3.7 0.0098 16.0 0.1 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 AMD18991.1 - 0.00011 22.7 0.4 3.5 8.3 0.0 4.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 AMD18991.1 - 0.00015 21.6 2.4 1.2 9.1 0.1 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD18991.1 - 0.0018 17.9 8.9 0.13 12.0 0.1 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 AMD18991.1 - 0.004 17.2 2.0 10 6.6 0.0 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_21 PF09976.4 AMD18991.1 - 0.0079 16.1 2.2 0.55 10.1 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 AMD18991.1 - 0.0096 15.5 10.7 5.9 6.6 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_15 PF13429.1 AMD18991.1 - 0.018 14.1 0.9 4.4 6.2 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 AMD18991.1 - 3.1 8.4 6.0 68 4.2 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat SH3_9 PF14604.1 AMD18992.1 - 2.4e-13 49.4 0.0 5e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 AMD18992.1 - 2.6e-12 45.9 0.0 6.9e-12 44.5 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 AMD18992.1 - 1.9e-07 30.4 0.0 4e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Cwf_Cwc_15 PF04889.7 AMD18993.1 - 7.9e-17 61.7 27.9 2e-07 31.0 0.6 3.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.8 AMD18993.1 - 0.27 10.8 5.8 0.37 10.3 4.0 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region APG6 PF04111.7 AMD18993.1 - 1.1 8.2 6.0 1.3 7.9 4.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 SLS PF14611.1 AMD18994.1 - 2.8e-26 92.2 6.1 4.6e-26 91.5 4.2 1.4 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Pro_dh PF01619.13 AMD18996.1 - 1.3e-54 185.3 0.0 1.7e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase ATP_bind_4 PF01902.12 AMD18997.1 - 9.9e-36 123.1 0.0 4.4e-35 121.0 0.0 2.0 1 1 0 1 1 1 1 ATP-binding region Ribonuc_L-PSP PF01042.16 AMD18997.1 - 4e-15 55.6 0.0 1.4e-10 41.0 0.0 2.8 3 1 0 3 3 3 2 Endoribonuclease L-PSP Sec1 PF00995.18 AMD18999.1 - 9.3e-90 301.8 2.1 1.1e-89 301.6 1.5 1.0 1 0 0 1 1 1 1 Sec1 family Glyco_hydro_81 PF03639.8 AMD19000.1 - 2.2e-225 749.8 4.8 2.6e-225 749.5 3.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 DUF4477 PF14780.1 AMD19001.1 - 0.0031 16.9 2.2 0.033 13.5 0.3 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4477) WD40 PF00400.27 AMD19002.1 - 3.9e-05 23.3 2.2 0.3 11.0 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat CPSF_A PF03178.10 AMD19002.1 - 0.0081 15.2 0.2 1.2 8.1 0.0 3.2 3 1 0 3 3 3 1 CPSF A subunit region Lactonase PF10282.4 AMD19002.1 - 0.014 14.5 0.1 3.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Kinesin-relat_1 PF12711.2 AMD19003.1 - 0.069 13.5 0.5 0.099 13.0 0.4 1.2 1 0 0 1 1 1 0 Kinesin motor Sec5 PF15469.1 AMD19004.1 - 1.5e-48 164.9 4.3 1.5e-48 164.9 3.0 2.3 3 0 0 3 3 3 1 Exocyst complex component Sec5 LSM PF01423.17 AMD19005.1 - 2.6e-15 55.6 0.1 3.1e-15 55.4 0.1 1.1 1 0 0 1 1 1 1 LSM domain Tail_tube PF10618.4 AMD19005.1 - 0.0019 17.9 0.0 0.0081 15.8 0.0 1.8 1 1 1 2 2 2 1 Phage tail tube protein SM-ATX PF14438.1 AMD19005.1 - 0.022 14.7 0.2 0.054 13.4 0.1 1.7 1 1 0 1 1 1 0 Ataxin 2 SM domain PTPS PF01242.14 AMD19005.1 - 0.087 12.5 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase Pep3_Vps18 PF05131.9 AMD19006.1 - 9e-38 129.0 0.0 5.1e-37 126.5 0.0 2.3 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.15 AMD19006.1 - 5.2e-08 32.5 0.5 5.2e-08 32.5 0.4 2.9 2 1 0 2 2 2 1 Region in Clathrin and VPS zf-RING_2 PF13639.1 AMD19006.1 - 4.1e-05 23.3 4.2 0.0001 22.0 2.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 AMD19006.1 - 0.00059 19.4 3.4 0.0023 17.5 2.4 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD19006.1 - 0.0014 18.5 2.3 0.0014 18.5 1.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.4 AMD19006.1 - 0.0095 16.1 0.9 0.0095 16.1 0.6 2.7 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.1 AMD19006.1 - 0.015 14.9 10.3 0.09 12.5 7.1 2.3 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.1 AMD19006.1 - 0.085 12.5 1.9 0.25 11.1 1.3 1.8 1 0 0 1 1 1 0 RING-type zinc-finger STN1_2 PF09170.5 AMD19006.1 - 0.72 9.5 7.1 0.33 10.6 1.2 2.5 2 0 0 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 TFIID_30kDa PF03540.8 AMD19007.1 - 2.1e-27 94.7 0.1 3.4e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit CBFD_NFYB_HMF PF00808.18 AMD19007.1 - 0.12 12.4 0.1 1.2 9.2 0.0 2.4 2 1 1 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 AMD19007.1 - 0.15 11.8 0.2 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 Bromodomain associated CDC37_N PF03234.9 AMD19008.1 - 2e-66 223.6 12.1 2e-66 223.6 8.4 3.0 2 1 1 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 AMD19008.1 - 4.5e-44 149.9 2.6 4.5e-44 149.9 1.8 2.8 4 0 0 4 4 4 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 AMD19008.1 - 6.1e-27 93.3 8.4 2e-26 91.7 4.0 2.8 2 0 0 2 2 2 1 Cdc37 C terminal domain HCMV_UL139 PF12507.3 AMD19008.1 - 0.02 15.0 1.6 0.048 13.8 0.1 2.2 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein DUF2415 PF10313.4 AMD19009.1 - 2.3e-20 71.9 1.4 4.7e-20 70.9 1.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) Stb3 PF10330.4 AMD19010.1 - 1.3e-32 111.3 0.1 1.3e-32 111.3 0.0 2.0 2 0 0 2 2 2 1 Putative Sin3 binding protein Suf PF05843.9 AMD19010.1 - 0.0027 17.5 11.8 0.0027 17.5 8.2 2.0 2 0 0 2 2 2 1 Suppressor of forked protein (Suf) zf-DHHC PF01529.15 AMD19010.1 - 0.028 13.7 0.5 0.044 13.1 0.4 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase PAT1 PF09770.4 AMD19010.1 - 0.75 7.9 34.4 0.044 12.0 20.2 1.5 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF3533 PF12051.3 AMD19010.1 - 0.95 8.1 7.7 1.5 7.4 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) AAA_23 PF13476.1 AMD19010.1 - 1.9 8.7 12.6 0.5 10.6 6.0 1.9 2 0 0 2 2 2 0 AAA domain BRF1 PF07741.8 AMD19010.1 - 1.9 8.7 14.4 0.16 12.2 5.5 2.5 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Activator_LAG-3 PF11498.3 AMD19010.1 - 8.1 5.0 41.1 16 4.0 28.5 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4175 PF13779.1 AMD19010.1 - 8.6 3.9 34.0 13 3.3 23.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FLO_LFY PF01698.11 AMD19010.1 - 8.8 5.0 16.0 2.7 6.7 6.7 2.2 2 0 0 2 2 2 0 Floricaula / Leafy protein Stm1_N PF09598.5 AMD19011.1 - 1.8e-16 60.5 4.5 1.8e-16 60.5 3.1 3.5 2 2 1 3 3 3 1 Stm1 Gly-rich_Ago1 PF12764.2 AMD19011.1 - 7.2 7.3 10.2 0.29 11.8 2.1 2.3 2 1 0 2 2 2 0 Glycine-rich region of argonaut NUDIX PF00293.23 AMD19012.1 - 1.9e-16 59.9 0.0 4.7e-16 58.6 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain AMP-binding PF00501.23 AMD19013.1 - 1.6e-86 290.2 0.0 2e-86 289.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 AMD19013.1 - 6.9e-20 71.7 0.2 1.8e-19 70.4 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sec7 PF01369.15 AMD19014.1 - 8.5e-64 214.7 0.4 4.3e-63 212.4 0.0 2.5 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.2 AMD19014.1 - 8.9e-52 174.8 3.6 8.9e-52 174.8 2.5 4.6 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 AMD19014.1 - 4.2e-28 96.6 0.9 4.2e-28 96.6 0.6 4.0 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) GTP_EFTU PF00009.22 AMD19015.1 - 1.9e-47 161.1 0.0 4.9e-47 159.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 AMD19015.1 - 1e-23 83.3 0.5 2.2e-23 82.3 0.4 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 AMD19015.1 - 7.9e-06 25.9 2.6 1.2e-05 25.3 0.4 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AMD19015.1 - 0.00015 21.6 0.3 0.00057 19.8 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase PAT1 PF09770.4 AMD19015.1 - 7.7 4.6 56.3 12 4.0 39.0 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 IPK PF03770.11 AMD19016.1 - 4.7e-50 169.9 0.1 5.9e-50 169.6 0.1 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase NADPH_Ox PF08414.5 AMD19016.1 - 0.008 16.2 0.1 0.019 15.0 0.1 1.6 1 0 0 1 1 1 1 Respiratory burst NADPH oxidase Zip PF02535.17 AMD19017.1 - 3e-58 197.3 8.4 3e-58 197.3 5.8 1.3 2 0 0 2 2 2 1 ZIP Zinc transporter HupE_UreJ PF04955.7 AMD19017.1 - 0.00038 19.8 4.4 0.00038 19.8 3.1 1.9 2 0 0 2 2 2 1 HupE / UreJ protein Cation_ATPase_C PF00689.16 AMD19017.1 - 0.01 15.3 0.3 2.2 7.7 0.0 2.5 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus HMG_box PF00505.14 AMD19018.1 - 8e-12 45.2 3.1 8e-12 45.2 2.1 2.5 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 AMD19018.1 - 2.7e-08 34.0 2.4 2.7e-08 34.0 1.7 2.4 2 1 0 2 2 2 1 HMG-box domain Mit_KHE1 PF10173.4 AMD19018.1 - 0.59 9.9 6.4 1.1 9.1 0.8 2.4 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related MRP-S28 PF10213.4 AMD19019.1 - 5.3e-49 165.5 4.7 1.1e-48 164.4 3.2 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein PRANC PF09372.5 AMD19019.1 - 0.037 13.9 0.1 0.11 12.5 0.1 1.7 2 0 0 2 2 2 0 PRANC domain DUF3540 PF12059.3 AMD19019.1 - 0.14 11.7 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) DUF2935 PF11155.3 AMD19019.1 - 0.14 12.2 2.1 1.6 8.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) PRK PF00485.13 AMD19019.1 - 0.38 10.2 3.8 0.24 10.9 0.3 2.2 2 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Ada3 PF10198.4 AMD19020.1 - 1.3e-46 157.6 3.9 1.3e-46 157.6 2.7 2.1 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 DUF4404 PF14357.1 AMD19020.1 - 0.43 11.0 9.4 0.2 12.1 1.4 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Peptidase_M16 PF00675.15 AMD19021.1 - 2.3e-53 179.9 0.1 9.4e-53 177.9 0.0 2.1 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 AMD19021.1 - 1.2e-38 132.5 0.0 3e-38 131.3 0.0 1.6 2 0 0 2 2 2 1 Peptidase M16 inactive domain CybS PF05328.7 AMD19022.1 - 7e-46 155.1 0.0 8.4e-46 154.8 0.0 1.1 1 0 0 1 1 1 1 CybS Sdh_cyt PF01127.17 AMD19022.1 - 0.28 10.9 1.5 1.8 8.4 1.1 2.0 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PXA PF02194.10 AMD19024.1 - 2.8e-06 27.0 0.9 1.9e-05 24.2 0.1 2.5 2 1 1 3 3 3 1 PXA domain PseudoU_synth_2 PF00849.17 AMD19025.1 - 3.4e-18 66.0 0.3 4.2e-15 55.9 0.2 2.2 1 1 0 1 1 1 1 RNA pseudouridylate synthase Nipped-B_C PF12830.2 AMD19026.1 - 7.2e-38 130.0 0.6 7.2e-38 130.0 0.4 3.3 5 0 0 5 5 5 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 AMD19026.1 - 1.2e-14 53.8 1.2 3.6e-13 49.1 0.8 2.9 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.1 AMD19026.1 - 0.0086 16.3 0.5 28 5.0 0.1 4.0 3 1 0 3 3 3 1 HEAT repeats Opacity PF02462.10 AMD19026.1 - 0.055 13.3 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Opacity family porin protein CoA_transf_3 PF02515.12 AMD19026.1 - 0.068 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 CoA-transferase family III SAS4 PF15460.1 AMD19027.1 - 1.1e-25 89.3 6.5 3.9e-25 87.6 4.5 1.9 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Metallophos PF00149.23 AMD19028.1 - 8e-16 58.0 1.6 1.3e-15 57.3 1.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Sec10 PF07393.6 AMD19029.1 - 2.6e-181 604.4 23.4 3.2e-181 604.1 16.2 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 IMS_C PF11799.3 AMD19029.1 - 0.028 14.3 1.2 0.086 12.7 0.1 2.3 2 1 0 2 2 2 0 impB/mucB/samB family C-terminal domain Phosducin PF02114.11 AMD19030.1 - 6e-05 21.8 0.0 7.2e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.15 AMD19030.1 - 0.00074 19.1 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin ubiquitin PF00240.18 AMD19031.1 - 4.5e-35 118.8 0.6 1.2e-34 117.4 0.5 1.7 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.14 AMD19031.1 - 1.1e-23 82.7 1.0 2.1e-23 81.8 0.7 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.3 AMD19031.1 - 1.3e-19 69.6 0.7 1.3e-19 69.6 0.5 1.9 3 0 0 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 AMD19031.1 - 9.9e-06 25.7 0.4 4.4e-05 23.6 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 AMD19031.1 - 0.00018 21.2 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 AMD19031.1 - 0.00092 19.0 0.4 0.0022 17.8 0.3 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 AMD19031.1 - 0.0054 16.8 0.5 0.0072 16.4 0.4 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain IBR PF01485.16 AMD19031.1 - 0.0076 16.0 0.5 0.011 15.5 0.4 1.3 1 0 0 1 1 1 1 IBR domain DUF2870 PF11069.3 AMD19031.1 - 0.071 13.1 0.1 0.17 11.9 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2870) DUF2207 PF09972.4 AMD19031.1 - 0.073 11.6 0.5 0.077 11.5 0.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Plexin_cytopl PF08337.7 AMD19031.1 - 0.24 9.6 1.5 5.6 5.1 0.0 2.0 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain DUF3250 PF11618.3 AMD19032.1 - 0.084 13.0 0.2 0.63 10.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3250) LGFP PF08310.6 AMD19032.1 - 0.14 11.7 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 LGFP repeat PRELI PF04707.9 AMD19033.1 - 4.9e-54 182.1 0.4 6.8e-54 181.6 0.3 1.1 1 0 0 1 1 1 1 PRELI-like family zf-DHHC PF01529.15 AMD19034.1 - 3.3e-31 108.0 13.9 3.3e-31 108.0 9.6 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase dCMP_cyt_deam_1 PF00383.17 AMD19036.1 - 8.3e-17 60.7 0.3 1.1e-16 60.3 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 AMD19036.1 - 1.4e-07 31.5 0.0 2.1e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region PolC_DP2 PF03833.8 AMD19036.1 - 0.066 10.8 0.3 0.074 10.7 0.2 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 LmjF365940-deam PF14421.1 AMD19036.1 - 0.81 9.0 2.9 10 5.4 0.6 2.0 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases Peptidase_M24 PF00557.19 AMD19037.1 - 2.3e-49 167.8 0.1 2.8e-49 167.5 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 ATP-cone PF03477.11 AMD19037.1 - 0.0099 16.2 0.3 0.77 10.2 0.1 2.3 2 0 0 2 2 2 1 ATP cone domain DUF3222 PF11519.3 AMD19037.1 - 0.4 10.6 3.8 0.45 10.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3222) Pkinase PF00069.20 AMD19038.1 - 4.1e-65 219.5 0.0 6.4e-65 218.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19038.1 - 1.3e-36 126.0 0.0 2.1e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19038.1 - 1.1e-08 34.3 0.0 1.5e-07 30.6 0.0 2.5 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 AMD19038.1 - 0.012 14.6 0.0 0.037 13.0 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD19038.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SGT1 PF07093.6 AMD19039.1 - 5.9e-33 114.1 17.5 7.7e-32 110.4 1.4 2.7 1 1 1 2 2 2 2 SGT1 protein APG5 PF04106.7 AMD19040.1 - 1.5e-44 151.8 0.0 2e-44 151.4 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 Methyltransf_23 PF13489.1 AMD19041.1 - 2.1e-16 60.0 0.0 4.5e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD19041.1 - 8.1e-16 58.3 0.1 7.6e-15 55.1 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD19041.1 - 2.6e-09 37.4 0.0 7.6e-09 35.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD19041.1 - 7.5e-09 35.3 0.0 1.5e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD19041.1 - 1.1e-08 35.3 0.0 2.2e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD19041.1 - 4.6e-07 30.4 0.0 1.4e-06 28.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 AMD19041.1 - 2.7e-05 24.1 0.0 8.1e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain DUF3419 PF11899.3 AMD19041.1 - 0.011 14.4 0.0 0.021 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) NNMT_PNMT_TEMT PF01234.12 AMD19041.1 - 0.068 12.1 0.0 5.4 5.8 0.0 2.2 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family Nucleo_P87 PF07267.6 AMD19041.1 - 9.7 4.7 11.6 15 4.0 8.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 ACPS PF01648.15 AMD19042.1 - 3.1e-13 49.5 0.0 5.6e-13 48.7 0.0 1.4 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily ABC_membrane_2 PF06472.10 AMD19043.1 - 4.6e-86 288.4 11.4 4.6e-86 288.4 7.9 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 AMD19043.1 - 9.1e-14 51.9 0.0 2.3e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 AMD19043.1 - 0.0059 15.8 0.1 0.32 10.1 0.0 2.2 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Nop53 PF07767.6 AMD19045.1 - 1.9e-90 303.6 43.7 2.2e-90 303.4 30.3 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Oxysterol_BP PF01237.13 AMD19046.1 - 1.3e-84 283.7 0.7 1.6e-84 283.4 0.5 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein DHFR_1 PF00186.14 AMD19047.1 - 5.7e-29 100.7 0.0 7.4e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase CheX PF13690.1 AMD19048.1 - 0.013 15.3 0.0 0.022 14.5 0.0 1.4 1 1 0 1 1 1 0 Chemotaxis phosphatase CheX Pyr_redox_3 PF13738.1 AMD19049.1 - 4.4e-23 82.4 0.0 9e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.14 AMD19049.1 - 5e-17 61.2 0.4 1.6e-11 43.1 0.0 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 AMD19049.1 - 1.1e-10 41.8 0.0 2.2e-10 40.7 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 AMD19049.1 - 2.8e-09 36.3 0.1 1.1e-06 27.8 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.14 AMD19049.1 - 8.5e-06 25.0 0.0 5.2e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 AMD19049.1 - 6.5e-05 22.8 0.0 0.00046 20.1 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 AMD19049.1 - 0.00045 20.5 1.1 0.42 11.0 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 AMD19049.1 - 0.0012 18.0 0.0 0.0043 16.2 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.19 AMD19049.1 - 0.0031 16.4 0.1 0.0057 15.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.1 AMD19049.1 - 0.005 17.0 0.0 3.6 7.9 0.0 2.9 2 1 0 2 2 2 1 Putative NAD(P)-binding DAO PF01266.19 AMD19049.1 - 0.038 12.9 0.2 0.27 10.1 0.0 2.4 3 0 0 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 AMD19049.1 - 0.12 11.2 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein TrkA_N PF02254.13 AMD19049.1 - 0.15 12.0 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Ribosomal_L35Ae PF01247.13 AMD19050.1 - 6.8e-43 144.3 0.9 7.6e-43 144.2 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 AMD19050.1 - 7.9e-05 22.5 0.0 0.23 11.4 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain Pkinase PF00069.20 AMD19051.1 - 5.4e-64 215.8 0.0 9.1e-64 215.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19051.1 - 1.5e-38 132.3 0.0 2.5e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19051.1 - 6.5e-08 31.8 0.0 1.1e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD19051.1 - 0.01 14.8 0.7 0.029 13.4 0.5 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD19051.1 - 0.023 14.4 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family GrpE PF01025.14 AMD19052.1 - 5.3e-51 172.4 9.4 6.7e-51 172.1 6.5 1.1 1 0 0 1 1 1 1 GrpE Y_phosphatase3 PF13350.1 AMD19052.1 - 0.043 14.0 0.7 0.066 13.4 0.3 1.4 1 1 0 1 1 1 0 Tyrosine phosphatase family DUF4349 PF14257.1 AMD19052.1 - 0.074 12.2 1.9 0.1 11.7 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) TPD52 PF04201.10 AMD19052.1 - 0.084 12.5 8.1 0.12 12.1 5.6 1.2 1 0 0 1 1 1 0 Tumour protein D52 family NIF3 PF01784.13 AMD19052.1 - 0.085 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) FAM75 PF14650.1 AMD19052.1 - 0.2 11.0 9.3 3.5 6.9 0.2 2.0 1 1 1 2 2 2 0 FAM75 family IncA PF04156.9 AMD19052.1 - 0.34 10.4 15.9 0.87 9.1 11.0 1.6 1 1 0 1 1 1 0 IncA protein DUF848 PF05852.6 AMD19052.1 - 0.55 10.0 13.3 9.5 6.0 7.3 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Atg14 PF10186.4 AMD19052.1 - 0.75 8.6 5.6 0.93 8.3 3.9 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 UPF0242 PF06785.6 AMD19052.1 - 1.7 7.2 7.3 2.2 6.8 5.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Pkinase PF00069.20 AMD19053.1 - 2.6e-67 226.7 0.0 3.7e-67 226.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19053.1 - 4.3e-37 127.5 0.0 7.7e-37 126.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19053.1 - 9.8e-08 31.2 0.0 1.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 AMD19053.1 - 0.021 13.6 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 AMD19053.1 - 0.034 13.8 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 AMD19053.1 - 0.048 12.7 0.0 0.091 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.27 AMD19054.1 - 0.0053 16.5 6.3 1.8 8.6 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 AMD19054.1 - 0.031 14.1 0.1 0.077 12.8 0.0 1.7 1 0 0 1 1 1 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex PHD PF00628.24 AMD19055.1 - 5e-11 42.1 5.7 5e-11 42.1 4.0 2.1 2 0 0 2 2 2 1 PHD-finger WD40_alt PF14077.1 AMD19055.1 - 0.54 9.9 2.9 17 5.1 0.0 2.9 1 1 1 2 2 2 0 Alternative WD40 repeat motif DUF1691 PF07950.6 AMD19056.1 - 9.3e-28 96.3 4.3 6.9e-14 51.6 0.9 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) LRR_4 PF12799.2 AMD19057.1 - 0.0012 18.4 15.6 0.089 12.4 0.2 5.4 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) Gag_p12 PF01141.13 AMD19057.1 - 0.043 13.9 0.0 0.17 12.0 0.0 2.0 1 0 0 1 1 1 0 Gag polyprotein, inner coat protein p12 LRR_7 PF13504.1 AMD19057.1 - 0.33 11.3 6.7 23 5.7 0.2 5.7 6 0 0 6 6 6 0 Leucine rich repeat DUF4112 PF13430.1 AMD19058.1 - 7e-31 106.2 1.3 9.2e-31 105.9 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) AAA PF00004.24 AMD19059.1 - 1.4e-40 138.5 0.0 2.2e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 AMD19059.1 - 1.8e-06 28.1 0.2 0.00043 20.4 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 AMD19059.1 - 7.2e-06 26.0 0.0 1.8e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 AMD19059.1 - 1.4e-05 24.1 0.0 2.4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 AMD19059.1 - 3.8e-05 23.4 0.2 0.00019 21.1 0.0 2.3 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 AMD19059.1 - 0.00011 22.2 0.0 0.0024 17.9 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 AMD19059.1 - 0.00088 18.3 0.0 0.0017 17.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 AMD19059.1 - 0.0011 18.9 0.1 0.0034 17.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 AMD19059.1 - 0.0022 17.9 0.0 0.0051 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD19059.1 - 0.0045 17.7 0.1 0.013 16.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD19059.1 - 0.0065 16.7 0.3 0.023 15.0 0.0 2.2 3 0 0 3 3 1 1 AAA domain IstB_IS21 PF01695.12 AMD19059.1 - 0.0066 15.8 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 AMD19059.1 - 0.0075 16.0 0.3 0.015 15.0 0.2 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 AMD19059.1 - 0.0097 15.3 1.6 0.23 10.8 0.3 2.4 1 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 AMD19059.1 - 0.0098 15.0 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 AMD19059.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 AMD19059.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 AMD19059.1 - 0.018 14.7 0.0 0.19 11.3 0.0 2.5 2 0 0 2 2 2 0 NTPase TIP49 PF06068.8 AMD19059.1 - 0.019 13.7 0.0 0.035 12.8 0.0 1.5 1 0 0 1 1 1 0 TIP49 C-terminus NB-ARC PF00931.17 AMD19059.1 - 0.022 13.6 0.0 0.049 12.4 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.17 AMD19059.1 - 0.025 14.7 0.0 0.087 13.0 0.0 2.0 2 0 0 2 2 1 0 RNA helicase NACHT PF05729.7 AMD19059.1 - 0.03 13.9 0.1 0.32 10.6 0.0 2.2 1 1 0 2 2 2 0 NACHT domain KaiC PF06745.8 AMD19059.1 - 0.032 13.3 0.2 0.41 9.7 0.1 2.4 1 1 1 2 2 2 0 KaiC AAA_24 PF13479.1 AMD19059.1 - 0.049 13.2 0.2 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 AMD19059.1 - 0.05 12.7 0.1 0.098 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.11 AMD19059.1 - 0.059 12.6 0.2 0.19 10.9 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.4 AMD19059.1 - 0.13 11.1 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) HLH PF00010.21 AMD19060.1 - 5.2e-16 58.0 0.0 9e-16 57.3 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF592 PF04574.8 AMD19061.1 - 4.9e-65 217.7 0.4 1.3e-64 216.4 0.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF592) SIR2 PF02146.12 AMD19061.1 - 7.8e-63 211.4 0.0 1.4e-62 210.6 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.17 AMD19061.1 - 0.0023 17.7 0.0 0.45 10.2 0.0 2.9 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, central domain zf-met PF12874.2 AMD19062.1 - 2.4e-06 27.5 1.3 4.6e-06 26.6 0.9 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF3505 PF12013.3 AMD19062.1 - 0.022 14.9 0.1 0.037 14.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) zf-C2H2_2 PF12756.2 AMD19062.1 - 0.038 14.0 0.1 0.063 13.4 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF2318 PF10080.4 AMD19062.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-U1 PF06220.7 AMD19062.1 - 0.13 11.8 0.1 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 U1 zinc finger Nuf2 PF03800.9 AMD19063.1 - 2.1e-45 154.2 0.2 2.1e-45 154.2 0.1 2.4 2 1 0 2 2 2 1 Nuf2 family CENP-F_leu_zip PF10473.4 AMD19063.1 - 0.0044 16.8 24.7 0.0044 16.8 17.1 2.8 1 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.7 AMD19063.1 - 5.4 7.4 29.4 0.11 12.9 4.4 4.9 3 1 2 5 5 5 0 SlyX Reo_sigmaC PF04582.7 AMD19063.1 - 6.4 5.8 21.7 6.6 5.8 10.0 2.7 1 1 3 4 4 4 0 Reovirus sigma C capsid protein APG6 PF04111.7 AMD19063.1 - 7.3 5.5 42.1 0.031 13.3 13.5 2.4 1 1 0 2 2 2 0 Autophagy protein Apg6 TEX19 PF15553.1 AMD19064.1 - 1.4 8.7 3.3 2.1 8.1 0.3 2.4 2 1 0 2 2 2 0 Testis-expressed protein 19 Troponin PF00992.15 AMD19065.1 - 0.014 15.4 5.1 0.3 11.1 1.0 2.6 1 1 1 2 2 2 0 Troponin KIAA1430 PF13879.1 AMD19065.1 - 0.023 15.0 4.0 2.3 8.7 0.1 3.2 3 0 0 3 3 3 0 KIAA1430 homologue Spatacsin_C PF14649.1 AMD19065.1 - 0.046 12.5 0.2 0.074 11.9 0.1 1.4 1 0 0 1 1 1 0 Spatacsin C-terminus BEX PF04538.7 AMD19065.1 - 0.047 13.9 1.4 0.12 12.5 0.1 2.1 2 0 0 2 2 2 0 Brain expressed X-linked like family PAPS_reduct PF01507.14 AMD19066.1 - 2.8e-28 98.8 0.0 4e-27 95.1 0.0 2.1 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family CHCH PF06747.8 AMD19067.1 - 2.3e-06 27.3 0.5 3e-06 26.9 0.4 1.2 1 0 0 1 1 1 1 CHCH domain CMV_US PF08001.6 AMD19067.1 - 0.0033 16.5 0.0 0.0036 16.3 0.0 1.2 1 0 0 1 1 1 1 CMV US Cmc1 PF08583.5 AMD19067.1 - 0.0057 16.3 0.6 0.0079 15.9 0.4 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF1163 PF06651.6 AMD19067.1 - 0.029 13.8 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1163) Mannitol_dh_C PF08125.8 AMD19067.1 - 0.076 12.1 0.0 0.082 12.0 0.0 1.0 1 0 0 1 1 1 0 Mannitol dehydrogenase C-terminal domain Sdh5 PF03937.11 AMD19068.1 - 5.5e-25 86.8 0.2 9e-25 86.1 0.1 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase E1_DerP2_DerF2 PF02221.10 AMD19069.1 - 1.5e-24 86.7 0.0 1.7e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 AMD19069.1 - 0.002 18.1 0.0 0.0028 17.6 0.0 1.2 1 0 0 1 1 1 1 ML-like domain CopC PF04234.7 AMD19069.1 - 0.057 14.0 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 CopC domain Metallophos PF00149.23 AMD19070.1 - 3.4e-43 147.3 0.2 4.3e-43 147.0 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 AMD19070.1 - 0.00071 19.4 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PCI PF01399.22 AMD19071.1 - 2.6e-12 46.9 1.5 1.6e-11 44.4 0.1 2.7 2 1 1 3 3 3 1 PCI domain Smg4_UPF3 PF03467.10 AMD19072.1 - 1.2e-19 70.9 0.2 1.2e-19 70.9 0.1 2.1 3 0 0 3 3 3 1 Smg-4/UPF3 family CENP-Q PF13094.1 AMD19073.1 - 0.0091 16.0 10.6 0.014 15.3 7.3 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Antimicrobial_7 PF08102.6 AMD19073.1 - 0.12 12.4 0.6 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 Scorpion antimicrobial peptide DUF972 PF06156.8 AMD19073.1 - 0.27 11.5 13.7 3.5 8.0 3.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) HALZ PF02183.13 AMD19073.1 - 0.54 10.0 15.4 0.058 13.1 3.1 3.4 2 1 1 3 3 3 0 Homeobox associated leucine zipper DivIC PF04977.10 AMD19073.1 - 0.63 9.5 14.9 0.77 9.2 2.0 4.2 3 1 1 4 4 4 0 Septum formation initiator TBPIP PF07106.8 AMD19073.1 - 4.2 6.8 14.5 14 5.1 6.8 2.5 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Viral_P18 PF04521.8 AMD19073.1 - 4.2 6.8 7.9 3 7.2 2.1 2.4 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein IncA PF04156.9 AMD19073.1 - 4.6 6.8 14.3 3.8 7.0 8.7 1.8 1 1 0 1 1 1 0 IncA protein DUF904 PF06005.7 AMD19073.1 - 6.1 7.2 21.6 0.44 10.8 6.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF904) DUF948 PF06103.6 AMD19073.1 - 6.7 6.6 6.8 0.72 9.7 0.7 2.3 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) LSM PF01423.17 AMD19074.1 - 1.2e-18 66.3 0.1 2.1e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 AMD19074.1 - 0.0024 17.7 0.0 0.0039 17.0 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain DeoRC PF00455.17 AMD19074.1 - 0.037 13.6 0.2 0.041 13.5 0.1 1.1 1 0 0 1 1 1 0 DeoR C terminal sensor domain PRP38 PF03371.10 AMD19075.1 - 8.2e-44 149.2 2.9 1.1e-43 148.9 2.0 1.0 1 0 0 1 1 1 1 PRP38 family Myb_DNA-bind_2 PF08914.6 AMD19076.1 - 0.013 15.3 0.1 0.021 14.5 0.1 1.4 1 0 0 1 1 1 0 Rap1 Myb domain ACDC PF14733.1 AMD19076.1 - 0.11 12.5 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 AP2-coincident C-terminal Condensin2nSMC PF12422.3 AMD19077.1 - 0.0071 16.1 0.0 0.031 14.0 0.0 2.1 2 0 0 2 2 2 1 Condensin II non structural maintenance of chromosomes subunit DER1 PF04511.10 AMD19078.1 - 0.00013 21.4 11.3 0.00019 20.9 7.9 1.2 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.17 AMD19078.1 - 0.65 10.0 7.1 5.3 7.0 4.9 2.1 1 1 0 1 1 1 0 Rhomboid family Prefoldin PF02996.12 AMD19079.1 - 2.3e-30 104.6 2.7 3.2e-30 104.2 1.9 1.2 1 0 0 1 1 1 1 Prefoldin subunit DUF708 PF05341.6 AMD19080.1 - 0.035 13.8 0.1 0.16 11.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF708) CYSTM PF12734.2 AMD19081.1 - 3.1e-10 39.9 7.2 3.1e-10 39.9 5.0 4.1 3 2 0 3 3 3 1 Cysteine-rich TM module stress tolerance EamA PF00892.15 AMD19082.1 - 9.1e-12 45.1 25.4 2e-07 31.1 5.0 2.9 2 1 1 3 3 3 2 EamA-like transporter family TPT PF03151.11 AMD19082.1 - 8.2e-10 38.5 28.1 3.4e-06 26.7 8.2 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 AMD19082.1 - 4.4e-09 35.7 21.5 6e-09 35.2 14.9 1.2 1 1 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.10 AMD19082.1 - 1.4e-07 30.9 1.2 1.4e-07 30.9 0.8 1.9 3 0 0 3 3 3 1 Nucleotide-sugar transporter EmrE PF13536.1 AMD19082.1 - 2e-06 27.9 6.2 2e-06 27.9 4.3 3.1 3 1 0 3 3 3 1 Multidrug resistance efflux transporter UPF0546 PF10639.4 AMD19082.1 - 0.00014 21.6 13.5 0.00075 19.2 1.4 3.0 3 0 0 3 3 3 2 Uncharacterised protein family UPF0546 DUF914 PF06027.7 AMD19082.1 - 0.0026 16.6 19.2 0.36 9.6 13.1 2.1 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) MpPF26 PF07666.6 AMD19082.1 - 0.28 11.0 11.6 1 9.2 2.1 3.3 2 1 1 3 3 3 0 M penetrans paralogue family 26 CbtB PF09489.5 AMD19082.1 - 0.47 10.3 2.3 33 4.4 0.0 3.2 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) Wzy_C PF04932.10 AMD19082.1 - 7.9 6.2 13.2 3.2 7.5 6.1 2.5 1 1 1 2 2 2 0 O-Antigen ligase zf-C3HC4_2 PF13923.1 AMD19083.1 - 0.003 17.5 0.3 0.0075 16.2 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD19083.1 - 0.0042 16.7 0.2 0.01 15.4 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD19083.1 - 0.019 14.6 0.2 0.019 14.6 0.2 1.7 2 0 0 2 2 2 0 zinc-RING finger domain Fer2_3 PF13085.1 AMD19083.1 - 0.019 14.7 0.1 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-C3HC4_4 PF15227.1 AMD19083.1 - 0.45 10.4 5.0 0.094 12.6 0.4 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF2924 PF11149.3 AMD19083.1 - 0.54 10.2 3.2 0.4 10.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) Fibrillarin PF01269.12 AMD19084.1 - 3e-109 363.3 0.0 3.6e-109 363.0 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 AMD19084.1 - 4.1e-06 26.4 0.1 7.7e-06 25.5 0.0 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 AMD19084.1 - 0.047 13.2 0.0 0.077 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Steroid_dh PF02544.11 AMD19085.1 - 1.3e-32 112.5 9.0 2.8e-32 111.5 6.2 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 AMD19085.1 - 0.0016 17.8 1.2 0.0016 17.8 0.8 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.9 AMD19085.1 - 0.019 15.1 3.3 0.077 13.2 0.2 2.3 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 AMD19085.1 - 0.058 13.4 0.5 0.058 13.4 0.3 2.6 3 0 0 3 3 3 0 Phospholipid methyltransferase Pkinase PF00069.20 AMD19086.1 - 4.1e-40 137.5 0.0 1e-20 74.0 0.0 3.1 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19086.1 - 2.5e-13 49.7 0.0 7.3e-08 31.7 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 AMD19086.1 - 0.0053 15.7 0.0 0.74 8.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 AMD19086.1 - 0.1 12.3 0.0 0.27 10.9 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family EMP24_GP25L PF01105.19 AMD19087.1 - 7.2e-30 104.0 3.1 7.2e-30 104.0 2.1 1.4 2 0 0 2 2 2 1 emp24/gp25L/p24 family/GOLD PgaD PF13994.1 AMD19087.1 - 0.071 12.5 2.0 0.21 11.0 0.3 2.1 2 0 0 2 2 2 0 PgaD-like protein HEAT PF02985.17 AMD19088.1 - 2.3e-16 58.3 4.2 0.00087 19.1 0.0 8.2 8 0 0 8 8 8 4 HEAT repeat HEAT_EZ PF13513.1 AMD19088.1 - 6.6e-16 58.2 0.1 2.3e-10 40.6 0.0 5.6 5 1 1 6 6 6 1 HEAT-like repeat HEAT_2 PF13646.1 AMD19088.1 - 2.2e-12 47.0 0.0 2.6e-05 24.3 0.0 6.0 4 2 4 8 8 8 4 HEAT repeats CLASP_N PF12348.3 AMD19088.1 - 1.1e-05 24.9 4.5 0.018 14.3 0.1 3.8 3 0 0 3 3 3 2 CLASP N terminal Vac14_Fab1_bd PF12755.2 AMD19088.1 - 4.7e-05 23.7 1.0 0.8 10.1 0.0 4.8 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region Sec7_N PF12783.2 AMD19088.1 - 0.00021 20.7 6.9 0.0053 16.2 1.0 4.2 3 1 1 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal SH3_1 PF00018.23 AMD19089.1 - 3.1e-08 32.8 0.4 1.3e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 AMD19089.1 - 0.00044 19.7 0.2 0.0016 17.9 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SAICAR_synt PF01259.13 AMD19090.1 - 1.9e-99 331.8 0.0 2.2e-99 331.6 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Pkinase PF00069.20 AMD19091.1 - 3.4e-60 203.3 0.0 4.9e-60 202.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19091.1 - 1e-35 123.0 0.0 2.6e-23 82.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Vhr1 PF04001.8 AMD19091.1 - 0.021 14.7 0.3 5.2 7.0 0.2 2.8 3 0 0 3 3 3 0 Transcription factor Vhr1 Phage_GPO PF05929.6 AMD19091.1 - 0.14 11.3 0.3 0.22 10.7 0.2 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Pkinase PF00069.20 AMD19092.1 - 1.2e-70 237.6 0.2 3.3e-70 236.2 0.2 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19092.1 - 5.3e-51 173.1 0.1 9.6e-51 172.3 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19092.1 - 3.3e-08 32.8 0.0 6.8e-07 28.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 AMD19092.1 - 0.08 12.0 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Oxysterol_BP PF01237.13 AMD19093.1 - 2.3e-131 437.5 0.0 4e-131 436.7 0.0 1.4 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.1 AMD19093.1 - 3.5e-12 46.1 0.0 3.5e-05 23.9 0.1 3.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD19093.1 - 3.5e-11 43.2 0.0 1.5e-05 25.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 AMD19093.1 - 5e-11 41.8 0.0 1e-05 25.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 AMD19093.1 - 3.4e-09 36.9 0.1 0.0001 22.7 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) PH_8 PF15409.1 AMD19093.1 - 4.8e-09 36.1 0.2 1.3e-08 34.8 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 AMD19093.1 - 2.6e-08 34.0 0.2 7.2e-08 32.5 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 AMD19093.1 - 2.9e-07 30.7 0.9 1.9e-06 28.1 0.6 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Ank_3 PF13606.1 AMD19093.1 - 6.8e-07 28.9 0.0 0.0021 18.1 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Phos_pyr_kin PF08543.7 AMD19094.1 - 1.3e-73 247.2 0.1 1.7e-73 246.8 0.1 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 AMD19094.1 - 3.3e-34 118.4 0.3 5.2e-34 117.8 0.2 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.19 AMD19094.1 - 3e-06 26.5 0.0 5.3e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.10 AMD19094.1 - 0.019 14.1 1.5 3.2 6.8 0.0 2.6 3 0 0 3 3 3 0 Hydroxyethylthiazole kinase family zf-C2H2 PF00096.21 AMD19095.1 - 0.00012 22.2 3.0 0.01 16.1 0.2 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type PAT1 PF09770.4 AMD19095.1 - 0.0017 16.6 88.2 0.0017 16.6 61.1 2.1 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 zf-C2H2_4 PF13894.1 AMD19095.1 - 0.0022 18.1 4.5 0.42 11.0 0.4 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger His_Phos_1 PF00300.17 AMD19096.1 - 4.7e-40 137.2 0.0 1.3e-39 135.8 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Arginosuc_synth PF00764.14 AMD19097.1 - 2e-159 530.7 0.0 2.4e-159 530.5 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 AMD19097.1 - 6.2e-07 29.1 0.0 9e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 AMD19097.1 - 1.1e-05 24.8 0.0 2.1e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 AMD19097.1 - 0.00092 17.8 0.1 0.0017 16.9 0.1 1.4 1 0 0 1 1 1 1 tRNA methyl transferase Ish1 PF10281.4 AMD19097.1 - 0.054 13.5 0.0 0.41 10.7 0.0 2.3 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein NAD_Gly3P_dh_N PF01210.18 AMD19098.1 - 8e-50 168.6 0.0 1.7e-49 167.6 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 AMD19098.1 - 1.2e-46 158.1 0.1 2.1e-46 157.3 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.12 AMD19098.1 - 0.011 16.0 0.0 7.3 7.0 0.0 2.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF21 PF01595.15 AMD19099.1 - 8.2e-33 113.2 0.1 1.4e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 AMD19099.1 - 0.00077 19.2 0.0 0.45 10.3 0.0 2.9 2 0 0 2 2 2 2 CBS domain Pkinase PF00069.20 AMD19100.1 - 6e-56 189.4 0.0 3.9e-55 186.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19100.1 - 1e-23 83.7 0.1 2.1e-23 82.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19100.1 - 1.4e-05 24.2 0.0 2.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD19100.1 - 0.0016 18.1 0.0 0.012 15.3 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 AMD19100.1 - 0.0025 17.1 0.1 0.0051 16.1 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Pribosyl_synth PF14572.1 AMD19101.1 - 6e-42 143.4 0.1 1.1e-41 142.6 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 AMD19101.1 - 6.7e-37 125.7 0.5 3.9e-36 123.3 0.0 2.4 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 AMD19101.1 - 3e-11 43.1 0.1 8.3e-11 41.6 0.1 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Actin PF00022.14 AMD19102.1 - 2e-113 378.8 0.0 2.3e-113 378.5 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 AMD19102.1 - 0.0016 17.0 0.0 0.0068 15.0 0.0 1.9 1 1 0 1 1 1 1 MreB/Mbl protein Pkinase PF00069.20 AMD19103.1 - 3.6e-50 170.5 0.0 6.9e-50 169.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19103.1 - 2.7e-21 75.8 0.0 7e-21 74.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 AMD19103.1 - 0.00013 21.8 0.0 0.17 11.5 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 AMD19103.1 - 0.0013 18.0 0.4 0.0031 16.8 0.2 1.6 1 0 0 1 1 1 1 RIO1 family ASF1_hist_chap PF04729.8 AMD19105.1 - 4.3e-65 218.0 0.1 6.1e-65 217.5 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone BUD22 PF09073.5 AMD19105.1 - 0.45 9.5 40.0 0.54 9.2 27.7 1.2 1 0 0 1 1 1 0 BUD22 DUF2201_N PF13203.1 AMD19105.1 - 6.2 5.9 14.8 7.7 5.5 10.3 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Mg_trans_NIPA PF05653.9 AMD19106.1 - 2e-10 40.1 15.6 1.1e-07 31.1 10.8 2.1 1 1 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 AMD19106.1 - 0.058 13.6 0.6 0.058 13.6 0.4 3.1 3 1 0 3 3 3 0 Multidrug resistance efflux transporter Apc1 PF12859.2 AMD19106.1 - 0.093 12.9 0.2 0.97 9.6 0.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 Multi_Drug_Res PF00893.14 AMD19106.1 - 0.26 11.7 6.2 0.083 13.3 1.7 2.2 2 0 0 2 2 2 0 Small Multidrug Resistance protein EamA PF00892.15 AMD19106.1 - 4.8 7.2 23.4 0.21 11.6 3.3 3.5 4 0 0 4 4 4 0 EamA-like transporter family His_Phos_1 PF00300.17 AMD19107.1 - 5.9e-30 104.4 0.2 7.4e-30 104.1 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 AMD19107.1 - 0.05 12.9 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Lectin_leg-like PF03388.8 AMD19108.1 - 7.1e-15 54.7 0.0 8.9e-08 31.5 0.0 2.2 2 0 0 2 2 2 2 Legume-like lectin family Pho86 PF11124.3 AMD19109.1 - 6e-88 294.7 1.2 6.8e-88 294.5 0.8 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 DUF3676 PF12429.3 AMD19111.1 - 0.016 14.8 1.0 0.016 14.8 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3676) NAP PF00956.13 AMD19112.1 - 6.9e-81 270.9 8.7 6.9e-81 270.9 6.0 2.0 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) CENP-B_dimeris PF09026.5 AMD19112.1 - 0.043 14.0 1.6 0.043 14.0 1.1 3.7 3 1 0 3 3 3 0 Centromere protein B dimerisation domain Ribul_P_3_epim PF00834.14 AMD19113.1 - 6.6e-70 234.3 0.0 8.2e-70 233.9 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.19 AMD19113.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family PcrB PF01884.12 AMD19113.1 - 0.037 13.2 0.0 0.058 12.6 0.0 1.3 1 0 0 1 1 1 0 PcrB family QRPTase_C PF01729.14 AMD19113.1 - 0.058 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain ThiG PF05690.9 AMD19113.1 - 0.084 11.9 0.1 0.16 11.0 0.0 1.5 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG CUE PF02845.11 AMD19113.1 - 0.091 12.2 2.7 0.1 12.1 0.2 2.1 2 0 0 2 2 2 0 CUE domain Alb1 PF09135.6 AMD19114.1 - 2.9e-17 63.2 8.8 2.9e-17 63.2 6.1 1.9 1 1 1 2 2 2 1 Alb1 HSP70 PF00012.15 AMD19114.1 - 0.043 11.7 1.0 0.056 11.3 0.7 1.1 1 0 0 1 1 1 0 Hsp70 protein DUF2413 PF10310.4 AMD19115.1 - 1.1e-111 373.8 21.3 1.2e-111 373.6 14.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2413) FliG_M PF14841.1 AMD19115.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 FliG middle domain Tir_receptor_C PF07489.6 AMD19115.1 - 3.5 7.3 9.3 6.9 6.3 6.4 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF1687 PF07955.6 AMD19116.1 - 5.2e-26 91.1 0.1 6.4e-26 90.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) LSM PF01423.17 AMD19117.1 - 1.2e-12 47.2 0.2 1.8e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 LSM domain Acyl-CoA_dh_1 PF00441.19 AMD19118.1 - 7.1e-19 68.3 0.2 1.1e-18 67.7 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 AMD19118.1 - 2.3e-09 36.5 0.0 4.4e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 AMD19118.1 - 0.0012 19.3 0.0 0.0031 18.0 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain GCD14 PF08704.5 AMD19119.1 - 2.2e-77 259.8 0.3 4.9e-76 255.4 0.2 2.1 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit RrnaAD PF00398.15 AMD19119.1 - 0.0036 16.3 0.0 0.01 14.9 0.0 1.7 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase DUF3748 PF12566.3 AMD19119.1 - 0.011 15.5 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) Methyltransf_26 PF13659.1 AMD19119.1 - 0.016 15.2 0.0 0.028 14.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 AMD19119.1 - 0.048 14.2 0.1 0.13 12.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain DUF2914 PF11141.3 AMD19119.1 - 0.083 12.4 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) M60-like PF13402.1 AMD19119.1 - 0.14 11.0 2.3 0.36 9.6 0.2 2.1 1 1 1 2 2 2 0 Peptidase M60-like family zf-H2C2 PF09337.5 AMD19120.1 - 9.5e-21 72.9 4.4 1.7e-20 72.1 3.1 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Acetyltransf_1 PF00583.19 AMD19120.1 - 0.00068 19.6 0.0 0.0028 17.6 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Helicase_RecD PF05127.9 AMD19120.1 - 0.012 15.2 0.0 0.029 14.0 0.0 1.6 1 0 0 1 1 1 0 Helicase Acetyltransf_3 PF13302.1 AMD19120.1 - 0.017 15.2 0.0 0.051 13.7 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF2755 PF10954.3 AMD19121.1 - 0.08 12.6 0.0 0.08 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2755) Pkinase PF00069.20 AMD19122.1 - 1.9e-54 184.5 0.0 3e-54 183.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19122.1 - 2.3e-37 128.5 0.0 4e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19122.1 - 0.00036 19.5 0.0 0.00066 18.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 AMD19122.1 - 0.0029 16.4 0.0 0.005 15.7 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 PG_binding_1 PF01471.13 AMD19122.1 - 0.044 13.7 0.1 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Putative peptidoglycan binding domain TrkH PF02386.11 AMD19123.1 - 1.8e-124 414.9 18.5 2.3e-123 411.2 9.5 2.1 2 0 0 2 2 2 2 Cation transport protein CutC PF03932.9 AMD19123.1 - 0.22 10.7 0.0 0.38 9.9 0.0 1.3 1 0 0 1 1 1 0 CutC family DUF4381 PF14316.1 AMD19123.1 - 1.7 8.7 3.4 3 7.9 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) HMG_box PF00505.14 AMD19124.1 - 2.6e-33 114.0 6.7 1.9e-18 66.4 0.3 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 AMD19124.1 - 5.9e-25 87.4 4.8 6e-12 45.7 0.2 2.2 1 1 1 2 2 2 2 HMG-box domain YABBY PF04690.8 AMD19124.1 - 1.8e-06 28.2 0.8 0.0079 16.4 0.4 2.2 1 1 1 2 2 2 2 YABBY protein DUF1074 PF06382.6 AMD19124.1 - 0.0021 18.0 5.7 0.072 13.0 0.9 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1074) DUF1644 PF07800.7 AMD19124.1 - 0.014 15.2 0.5 1.1 9.0 0.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1644) MCM_N PF14551.1 AMD19124.1 - 0.072 13.5 0.3 0.11 12.9 0.2 1.6 1 1 0 1 1 1 0 MCM N-terminal domain FAM195 PF14799.1 AMD19124.1 - 0.13 12.1 2.6 0.15 11.8 0.4 2.0 1 1 1 2 2 2 0 FAM195 family DUF3106 PF11304.3 AMD19124.1 - 1.6 9.1 9.7 3.9 7.9 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3106) CPSase_L_D2 PF02786.12 AMD19125.1 - 1.9e-115 383.4 0.5 5.8e-84 280.6 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 AMD19125.1 - 3.2e-48 162.5 0.0 7.5e-48 161.3 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 AMD19125.1 - 5.1e-42 143.5 0.0 1.1e-41 142.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.16 AMD19125.1 - 6.9e-42 142.4 0.4 1.8e-41 141.1 0.0 1.9 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_chain PF00289.17 AMD19125.1 - 1.2e-40 137.9 0.4 2.1e-20 72.8 0.0 3.5 4 0 0 4 4 4 2 Carbamoyl-phosphate synthase L chain, N-terminal domain CPSase_L_D3 PF02787.14 AMD19125.1 - 3.2e-40 136.7 0.1 7.7e-40 135.4 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.19 AMD19125.1 - 4.9e-34 117.4 0.4 2.5e-33 115.1 0.0 2.5 3 0 0 3 3 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp_4 PF13535.1 AMD19125.1 - 9.6e-33 113.4 0.1 3.6e-21 75.7 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 AMD19125.1 - 7.1e-23 80.8 0.1 2.4e-13 49.5 0.0 3.4 3 0 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.17 AMD19125.1 - 5.9e-22 77.4 0.0 7.7e-21 73.8 0.0 3.0 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.8 AMD19125.1 - 4.5e-16 58.8 1.2 2.7e-08 33.4 0.1 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 AMD19125.1 - 3.5e-15 55.7 0.3 2.1e-07 30.4 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.8 AMD19125.1 - 5e-06 26.1 0.1 7.9e-05 22.1 0.0 2.4 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.9 AMD19125.1 - 1.1e-05 25.3 0.7 0.16 11.8 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain mIF3 PF14877.1 AMD19126.1 - 2.4e-49 167.1 3.1 2.4e-49 167.1 2.2 2.0 2 0 0 2 2 2 1 Mitochondrial translation initiation factor DUF4479 PF14794.1 AMD19126.1 - 0.035 13.6 0.0 0.1 12.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) DUF607 PF04678.8 AMD19126.1 - 0.39 10.6 3.5 0.37 10.6 1.3 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF607 Solute_trans_a PF03619.11 AMD19127.1 - 1.1e-83 280.7 15.7 1.3e-83 280.4 10.9 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF1422 PF07226.6 AMD19127.1 - 0.61 9.8 6.1 0.41 10.4 2.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1422) Mito_carr PF00153.22 AMD19128.1 - 3.1e-62 206.2 0.9 9.6e-22 76.5 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein PAP2 PF01569.16 AMD19129.1 - 1.8e-15 56.7 1.5 4.3e-15 55.5 1.1 1.6 1 0 0 1 1 1 1 PAP2 superfamily DHC_N1 PF08385.7 AMD19130.1 - 2.2e-139 465.5 18.4 2.2e-139 465.5 12.7 4.5 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 AMD19130.1 - 3.5e-110 368.3 13.9 3.5e-110 368.3 9.6 4.6 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 AMD19130.1 - 2.3e-63 213.8 0.0 5.5e-63 212.5 0.0 1.7 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 Dynein_heavy PF03028.10 AMD19130.1 - 2.8e-47 161.2 2.8 2.2e-46 158.2 0.1 2.7 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 AMD19130.1 - 2.4e-32 111.6 0.1 5.5e-31 107.1 0.0 2.6 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 AMD19130.1 - 2.7e-28 98.7 7.1 6e-28 97.5 4.9 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.2 AMD19130.1 - 4.7e-27 94.6 0.1 2.8e-26 92.0 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.9 AMD19130.1 - 6.2e-25 87.5 0.0 6.3e-09 35.6 0.0 5.8 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_7 PF12775.2 AMD19130.1 - 1.6e-22 79.8 0.0 9.4e-22 77.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_22 PF13401.1 AMD19130.1 - 3.2e-14 53.1 0.8 0.00026 21.1 0.0 6.9 6 0 0 6 6 6 3 AAA domain AAA PF00004.24 AMD19130.1 - 6.5e-14 52.2 0.0 0.013 15.6 0.0 5.1 4 0 0 4 4 4 4 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 AMD19130.1 - 3.1e-08 33.9 0.2 0.18 12.1 0.0 4.6 4 0 0 4 4 3 2 AAA domain AAA_33 PF13671.1 AMD19130.1 - 7.4e-08 32.3 0.0 0.75 9.6 0.0 5.0 4 0 0 4 4 4 2 AAA domain AAA_17 PF13207.1 AMD19130.1 - 9.5e-08 32.8 1.2 0.44 11.3 0.0 5.8 5 0 0 5 5 4 2 AAA domain Zeta_toxin PF06414.7 AMD19130.1 - 1.1e-07 31.2 0.0 0.009 15.1 0.0 3.6 3 0 0 3 3 3 2 Zeta toxin AAA_19 PF13245.1 AMD19130.1 - 1e-06 28.3 1.2 0.49 10.1 0.0 3.9 4 0 0 4 4 4 2 Part of AAA domain AAA_16 PF13191.1 AMD19130.1 - 1.2e-06 28.6 4.0 1.8 8.5 0.0 5.7 5 1 1 6 6 5 3 AAA ATPase domain T2SE PF00437.15 AMD19130.1 - 1.3e-06 27.5 10.9 0.00082 18.3 0.0 4.9 6 0 0 6 6 6 2 Type II/IV secretion system protein AAA_30 PF13604.1 AMD19130.1 - 0.00059 19.4 0.1 6.8 6.2 0.0 3.8 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.1 AMD19130.1 - 0.0011 18.3 0.2 0.62 9.4 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 AMD19130.1 - 0.002 17.6 0.0 3.2 7.3 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_28 PF13521.1 AMD19130.1 - 0.015 15.2 0.5 40 4.1 0.0 4.8 5 0 0 5 5 5 0 AAA domain Mg_chelatase PF01078.16 AMD19130.1 - 0.074 12.2 3.3 1.6 7.8 0.1 3.8 3 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI Ras PF00071.17 AMD19131.1 - 2.9e-45 153.5 0.0 3.6e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD19131.1 - 1.3e-14 54.6 0.0 2.4e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD19131.1 - 8.7e-07 28.3 0.0 1.2e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 AMD19131.1 - 0.0016 17.6 0.0 0.011 14.8 0.0 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region tRNA_U5-meth_tr PF05958.6 AMD19132.1 - 8.9e-22 77.2 0.0 1e-20 73.7 0.0 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 AMD19132.1 - 1.2e-10 41.1 0.0 3.3e-10 39.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain TRAM PF01938.15 AMD19132.1 - 2.1e-09 37.0 0.0 3.5e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 TRAM domain Methyltransf_18 PF12847.2 AMD19132.1 - 1.3e-06 28.9 0.0 3.2e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 AMD19132.1 - 1.1e-05 24.9 0.0 2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.5 AMD19132.1 - 1.8e-05 24.3 0.0 3.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 AMD19132.1 - 2.7e-05 24.1 0.0 5.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 AMD19132.1 - 2.9e-05 23.3 0.0 4.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 AMD19132.1 - 0.00011 21.6 0.0 0.00023 20.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.11 AMD19132.1 - 0.0017 17.9 0.0 0.0045 16.5 0.0 1.8 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_4 PF02390.12 AMD19132.1 - 0.0041 16.1 0.0 0.0091 15.0 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.1 AMD19132.1 - 0.0043 17.3 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AMD19132.1 - 0.02 13.9 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 AMD19132.1 - 0.024 15.0 0.0 0.063 13.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 AMD19132.1 - 0.044 13.3 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Mak10 PF04112.8 AMD19133.1 - 2.7e-42 143.8 1.2 5.4e-42 142.8 0.8 1.6 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Ribosomal_L11_N PF03946.9 AMD19134.1 - 1.1e-17 63.2 0.3 3.8e-17 61.4 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 AMD19134.1 - 2.1e-10 40.5 1.0 3.9e-10 39.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain ACBP PF00887.14 AMD19135.1 - 5.5e-19 67.6 0.0 1.8e-18 65.9 0.0 1.8 2 0 0 2 2 2 1 Acyl CoA binding protein IMS PF00817.15 AMD19136.1 - 4.5e-42 143.3 0.0 8e-42 142.5 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family zf-C2H2_jaz PF12171.3 AMD19136.1 - 0.011 15.8 0.1 0.024 14.7 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 AMD19136.1 - 0.015 15.5 0.1 0.036 14.2 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type IMS_HHH PF11798.3 AMD19136.1 - 0.049 13.6 0.0 0.16 12.1 0.0 1.9 1 0 0 1 1 1 0 IMS family HHH motif zf-C2H2_6 PF13912.1 AMD19136.1 - 0.084 12.8 0.2 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger MAP65_ASE1 PF03999.7 AMD19137.1 - 2.2e-73 247.9 25.4 2.2e-73 247.9 17.6 2.3 2 1 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) TA0956 PF11513.3 AMD19137.1 - 0.0068 16.4 1.0 0.032 14.2 0.2 2.6 2 0 0 2 2 2 1 Thermoplasma acidophilum protein TA0956 Spore_III_AB PF09548.5 AMD19137.1 - 0.016 14.9 1.1 0.016 14.9 0.8 3.2 3 0 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Med22 PF06179.7 AMD19137.1 - 0.14 12.1 12.5 0.15 12.0 2.4 4.2 3 1 1 4 4 4 0 Surfeit locus protein 5 subunit 22 of Mediator complex SGS PF05002.10 AMD19138.1 - 1e-26 92.4 1.0 2.6e-26 91.1 0.1 2.2 2 0 0 2 2 2 1 SGS domain CS PF04969.11 AMD19138.1 - 3.5e-13 49.8 0.8 8.5e-13 48.6 0.6 1.7 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.1 AMD19138.1 - 2.4e-05 23.8 4.5 0.0017 17.9 0.7 2.4 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.1 AMD19138.1 - 0.0018 18.1 2.4 0.015 15.2 0.3 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD19138.1 - 0.0037 17.0 5.2 1.1 9.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 AMD19138.1 - 0.0075 16.8 0.1 0.2 12.3 0.0 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat Peptidase_C65 PF10275.4 AMD19138.1 - 0.071 12.4 0.7 0.15 11.4 0.5 1.4 1 0 0 1 1 1 0 Peptidase C65 Otubain TPR_16 PF13432.1 AMD19138.1 - 0.11 13.2 3.5 4.7 8.0 0.1 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat Apc3 PF12895.2 AMD19138.1 - 0.21 11.7 3.4 0.46 10.6 0.1 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 AMD19138.1 - 0.23 12.0 1.8 5.4 7.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 AMD19138.1 - 2.4 7.9 5.3 1.1 8.9 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat NOB1_Zn_bind PF08772.6 AMD19139.1 - 5.7e-26 90.1 0.2 1.3e-25 89.0 0.1 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like UPF0278 PF08745.6 AMD19139.1 - 0.009 15.2 0.5 4.9 6.3 0.0 3.0 2 1 1 3 3 3 2 UPF0278 family zf-RING_3 PF14369.1 AMD19139.1 - 0.035 14.1 0.6 0.086 12.8 0.4 1.7 1 0 0 1 1 1 0 zinc-finger DZR PF12773.2 AMD19139.1 - 0.07 12.9 1.4 0.15 11.9 0.9 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF2011 PF09428.5 AMD19139.1 - 0.21 11.4 8.7 0.1 12.4 1.7 2.3 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2011) Prp31_C PF09785.4 AMD19139.1 - 0.27 11.6 7.3 7.2 7.0 1.0 3.1 3 0 0 3 3 3 0 Prp31 C terminal domain AF1Q PF15017.1 AMD19139.1 - 5 7.0 8.0 0.6 10.0 2.1 1.9 2 0 0 2 2 2 0 Drug resistance and apoptosis regulator Flavoprotein PF02441.14 AMD19140.1 - 5.8e-43 145.6 0.0 1.3e-42 144.5 0.0 1.6 1 1 0 1 1 1 1 Flavoprotein SGT1 PF07093.6 AMD19140.1 - 6.8e-05 21.4 2.1 7.5e-05 21.3 1.4 1.2 1 0 0 1 1 1 1 SGT1 protein BTG PF07742.7 AMD19140.1 - 0.049 13.1 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 BTG family PPP4R2 PF09184.6 AMD19140.1 - 0.15 11.5 23.5 0.29 10.6 16.3 1.4 1 0 0 1 1 1 0 PPP4R2 DUF1510 PF07423.6 AMD19140.1 - 3.8 6.8 23.5 7.5 5.8 16.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 AMD19140.1 - 5.1 4.9 28.7 8.1 4.3 19.9 1.2 1 0 0 1 1 1 0 CDC45-like protein CIAPIN1 PF05093.8 AMD19141.1 - 1.8e-33 114.5 1.3 2.8e-33 113.9 0.9 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis zf-AN1 PF01428.11 AMD19142.1 - 1.2e-09 37.9 14.1 1.7e-09 37.3 9.8 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Hydrolase_6 PF13344.1 AMD19143.1 - 3.5e-23 81.4 0.0 1.2e-22 79.7 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AMD19143.1 - 1.5e-21 75.8 0.0 3e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 AMD19143.1 - 1.1e-05 25.7 0.0 0.5 10.5 0.0 3.3 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AMD19143.1 - 2.6e-05 24.7 0.0 0.032 14.6 0.0 3.0 1 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase TP_methylase PF00590.15 AMD19144.1 - 4e-43 147.5 0.1 7.2e-43 146.7 0.1 1.4 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.1 AMD19144.1 - 3.1e-06 27.3 0.0 7.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.1 AMD19144.1 - 0.00048 19.0 0.0 0.0011 17.9 0.0 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Nro1 PF12753.2 AMD19145.1 - 9.9e-136 452.8 10.4 1.1e-135 452.6 7.2 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 FAST_1 PF06743.10 AMD19145.1 - 0.0036 16.9 0.0 0.037 13.7 0.0 2.5 3 0 0 3 3 3 1 FAST kinase-like protein, subdomain 1 TPR_19 PF14559.1 AMD19145.1 - 0.0096 16.2 0.1 2.1 8.7 0.0 4.0 3 2 0 3 3 3 1 Tetratricopeptide repeat Hydrolase_2 PF07486.7 AMD19145.1 - 0.014 15.9 0.1 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 Cell Wall Hydrolase FCD PF07729.7 AMD19145.1 - 0.073 13.3 0.1 13 6.1 0.0 2.5 2 0 0 2 2 2 0 FCD domain TPR_14 PF13428.1 AMD19145.1 - 0.12 13.0 0.0 1.3e+02 3.6 0.0 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TRAPP PF04051.11 AMD19146.1 - 3.1e-36 124.1 0.0 4.1e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component TATR PF03430.8 AMD19146.1 - 0.048 12.2 0.0 0.069 11.7 0.0 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Methyltransf_28 PF02636.12 AMD19147.1 - 1.1e-08 34.8 0.1 1.6e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase XRN_N PF03159.13 AMD19148.1 - 1.9e-106 354.8 0.4 2.3e-105 351.2 0.0 2.5 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus Hanta_nucleocap PF00846.13 AMD19148.1 - 0.067 11.8 1.6 0.1 11.2 1.1 1.2 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein DEAD PF00270.24 AMD19150.1 - 4.3e-35 120.7 0.4 8.5e-34 116.4 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19150.1 - 6.1e-26 90.0 0.0 1.1e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD19150.1 - 0.00057 19.7 0.1 0.0017 18.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 AMD19150.1 - 0.0049 16.8 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Helicase C-terminal domain AAA_30 PF13604.1 AMD19150.1 - 0.027 14.0 0.0 0.058 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 AMD19150.1 - 0.095 12.8 0.1 0.37 10.9 0.0 2.0 2 1 0 2 2 2 0 AAA domain Pmp3 PF01679.12 AMD19151.1 - 3.8e-19 68.1 10.6 4.1e-19 68.0 7.4 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator BTP PF05232.7 AMD19151.1 - 0.21 11.3 4.0 0.25 11.1 2.7 1.2 1 0 0 1 1 1 0 Bacterial Transmembrane Pair family DUF3278 PF11683.3 AMD19151.1 - 0.4 10.6 3.2 0.49 10.3 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) CoxIIa PF08113.6 AMD19151.1 - 3.3 7.5 5.1 12 5.7 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IIa family DUF4021 PF13213.1 AMD19152.1 - 0.31 10.7 1.6 0.48 10.0 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4021) Ammonium_transp PF00909.16 AMD19153.1 - 0.12 10.8 0.5 0.15 10.5 0.4 1.1 1 0 0 1 1 1 0 Ammonium Transporter Family Presenilin PF01080.12 AMD19153.1 - 0.33 9.7 1.8 0.41 9.4 1.3 1.1 1 0 0 1 1 1 0 Presenilin CUE PF02845.11 AMD19155.1 - 2.8e-08 33.0 0.0 2.8e-08 33.0 0.0 1.9 2 0 0 2 2 2 1 CUE domain Lactamase_B PF00753.22 AMD19156.1 - 1.6e-21 76.8 0.1 2.7e-21 76.1 0.1 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 AMD19156.1 - 0.0051 16.3 0.4 0.012 15.1 0.2 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain WD40 PF00400.27 AMD19157.1 - 8.1e-11 41.3 0.5 1.8 8.5 0.0 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 AMD19157.1 - 0.017 14.8 1.3 0.91 9.3 0.0 4.0 3 1 2 5 5 5 0 Ciliary BBSome complex subunit 2, middle region E1-E2_ATPase PF00122.15 AMD19158.1 - 2.9e-45 154.0 1.9 1.3e-44 151.9 0.2 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 AMD19158.1 - 8.9e-30 104.7 0.0 1.9e-29 103.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 AMD19158.1 - 1e-12 47.9 4.6 1.3e-11 44.4 0.2 2.5 2 0 0 2 2 2 1 Heavy-metal-associated domain HAD PF12710.2 AMD19158.1 - 4.4e-12 46.5 0.6 1.7e-11 44.6 0.0 2.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AMD19158.1 - 0.0028 17.2 0.1 0.028 14.0 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CK_II_beta PF01214.13 AMD19159.1 - 7.5e-72 240.7 0.0 9e-72 240.4 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Hira PF07569.6 AMD19160.1 - 9.5e-87 289.7 2.1 5.5e-86 287.2 0.1 2.7 3 0 0 3 3 3 1 TUP1-like enhancer of split tRNA-synt_1b PF00579.20 AMD19161.1 - 9.2e-77 258.0 0.2 1.2e-76 257.6 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) FAD_binding_6 PF00970.19 AMD19162.1 - 1.7e-07 31.2 0.0 1.7e-05 24.8 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_9 PF08021.6 AMD19162.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain WD40 PF00400.27 AMD19163.1 - 3.5e-56 185.2 31.2 1.5e-11 43.6 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 AMD19163.1 - 0.00011 21.9 0.2 0.033 13.8 0.0 3.3 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A YmzC PF14157.1 AMD19163.1 - 0.01 15.6 0.0 0.051 13.4 0.0 2.2 2 0 0 2 2 2 1 YmzC-like protein IKI3 PF04762.7 AMD19163.1 - 0.017 12.9 2.0 0.54 7.9 0.6 2.3 2 0 0 2 2 2 0 IKI3 family Apc4_WD40 PF12894.2 AMD19163.1 - 0.018 14.5 0.1 1.3e+02 2.1 0.0 4.9 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.9 AMD19163.1 - 0.028 13.2 3.3 0.081 11.7 0.6 2.5 3 1 0 3 3 3 0 Coatomer WD associated region Nucleoporin_N PF08801.6 AMD19163.1 - 0.48 9.1 3.5 1.4 7.6 0.3 2.7 2 1 1 3 3 3 0 Nup133 N terminal like SNARE PF05739.14 AMD19164.1 - 3.7e-19 68.1 2.6 3.7e-19 68.1 1.8 2.6 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.1 AMD19164.1 - 4.9e-14 52.1 6.8 4.9e-14 52.1 4.7 2.6 2 1 0 2 2 2 1 Syntaxin-like protein SIR2 PF02146.12 AMD19164.1 - 0.054 13.2 0.4 0.054 13.2 0.3 1.8 1 1 0 2 2 2 0 Sir2 family WXG100 PF06013.7 AMD19164.1 - 0.096 12.6 7.2 9.4 6.3 0.3 4.0 3 2 2 5 5 5 0 Proteins of 100 residues with WXG TACC PF05010.9 AMD19164.1 - 0.13 11.9 8.7 4.5 6.9 0.0 2.4 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) Baculo_PEP_C PF04513.7 AMD19164.1 - 1.4 8.7 16.6 0.12 12.1 2.6 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin-6_N PF09177.6 AMD19164.1 - 3.2 8.2 12.8 0.88 10.0 0.1 3.4 1 1 1 3 3 3 0 Syntaxin 6, N-terminal ATP-synt_S1 PF05827.7 AMD19165.1 - 3.8e-45 154.4 0.0 5e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) DMA PF03474.9 AMD19166.1 - 0.01 15.6 0.1 0.062 13.1 0.0 2.3 2 0 0 2 2 2 1 DMRTA motif Prp18 PF02840.10 AMD19166.1 - 0.21 11.3 2.9 0.49 10.2 0.0 2.9 4 0 0 4 4 4 0 Prp18 domain Pkinase PF00069.20 AMD19167.1 - 4e-69 232.6 0.0 5.8e-69 232.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19167.1 - 9.7e-52 175.5 0.0 1.4e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19167.1 - 2.8e-07 29.8 0.0 2.1e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 AMD19167.1 - 0.00053 19.7 0.1 0.5 10.0 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 AMD19167.1 - 0.11 11.5 0.1 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 AMD19167.1 - 0.16 11.3 0.2 0.52 9.6 0.1 1.9 1 1 0 1 1 1 0 RIO1 family PQ-loop PF04193.9 AMD19169.1 - 3.6e-32 109.6 12.9 5.7e-16 57.8 2.1 2.6 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.11 AMD19169.1 - 3.2 7.7 11.1 0.63 9.9 0.4 3.5 2 2 1 3 3 3 0 Sugar efflux transporter for intercellular exchange PX PF00787.19 AMD19170.1 - 2.8e-16 59.2 0.0 3.8e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 PX domain Pyr_redox_2 PF07992.9 AMD19171.1 - 3.6e-29 102.0 0.1 4.6e-29 101.7 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 AMD19171.1 - 5e-19 68.4 0.0 3.4e-16 59.4 0.0 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 AMD19171.1 - 4.3e-09 36.7 0.0 1.6e-06 28.3 0.0 2.8 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 AMD19171.1 - 8.1e-06 24.9 2.7 0.91 8.3 0.1 4.3 3 2 1 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.1 AMD19171.1 - 6.7e-05 23.0 0.0 0.064 13.5 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding DAO PF01266.19 AMD19171.1 - 0.0002 20.3 0.3 0.19 10.5 0.0 3.0 2 1 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AMD19171.1 - 0.00027 20.9 0.0 0.023 14.7 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.15 AMD19171.1 - 0.0015 18.6 0.1 0.23 11.5 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.1 AMD19171.1 - 0.0026 16.7 0.0 0.12 11.3 0.0 2.8 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 AMD19171.1 - 0.0041 16.2 0.0 0.067 12.2 0.0 2.4 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.1 AMD19171.1 - 0.0078 15.9 0.0 0.48 10.1 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 AMD19171.1 - 0.008 15.0 3.8 1.9 7.2 0.2 3.3 3 1 1 4 4 4 2 FAD binding domain FAD_oxidored PF12831.2 AMD19171.1 - 0.035 13.1 0.1 4.4 6.2 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase ApbA PF02558.11 AMD19171.1 - 0.1 12.0 0.1 0.62 9.5 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 AMD19171.1 - 0.11 12.2 0.1 12 5.5 0.0 2.5 3 0 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Septin PF00735.13 AMD19172.1 - 1.1e-112 375.6 0.0 1.5e-112 375.1 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 AMD19172.1 - 7.3e-05 22.7 0.0 0.00016 21.6 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 AMD19172.1 - 0.00017 20.8 0.0 0.00068 18.8 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 AMD19172.1 - 0.00017 21.6 0.2 0.0085 16.2 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.1 AMD19172.1 - 0.0044 16.6 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain ERM PF00769.14 AMD19172.1 - 0.0072 15.8 4.0 0.013 15.0 2.8 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Dynamin_N PF00350.18 AMD19172.1 - 0.032 14.0 3.5 7.2 6.4 0.0 3.2 2 1 1 3 3 3 0 Dynamin family AAA_33 PF13671.1 AMD19172.1 - 0.048 13.5 0.1 0.31 10.9 0.0 2.1 1 1 1 2 2 2 0 AAA domain GTP_EFTU PF00009.22 AMD19172.1 - 0.055 12.9 0.3 0.83 9.0 0.0 2.6 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Miro PF08477.8 AMD19172.1 - 0.072 13.5 0.0 0.22 12.0 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein RNA_helicase PF00910.17 AMD19172.1 - 0.095 12.8 0.0 0.32 11.1 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Glycos_transf_3 PF00591.16 AMD19173.1 - 9.4e-67 225.0 0.0 1.4e-66 224.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 AMD19173.1 - 5.6e-06 25.8 0.0 1.2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Methyltransf_16 PF10294.4 AMD19174.1 - 1.5e-25 89.6 0.0 2.6e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.1 AMD19174.1 - 1.8e-09 37.3 0.0 3.4e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AMD19174.1 - 2.1e-06 27.2 0.0 4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 AMD19174.1 - 3.5e-06 26.8 0.0 6.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AMD19174.1 - 0.00015 21.7 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 AMD19174.1 - 0.00028 20.3 0.0 0.00045 19.6 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.2 AMD19174.1 - 0.00029 21.3 0.0 0.00058 20.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD19174.1 - 0.0017 18.7 0.0 0.0057 17.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 AMD19174.1 - 0.015 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TRM PF02005.11 AMD19174.1 - 0.038 12.9 0.0 0.056 12.3 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase GAS PF13851.1 AMD19175.1 - 3.2e-05 23.2 25.1 3.2e-05 23.2 17.4 7.3 2 1 5 7 7 7 2 Growth-arrest specific micro-tubule binding Mnd1 PF03962.10 AMD19175.1 - 0.005 16.5 7.9 0.005 16.5 5.5 7.4 1 1 6 7 7 7 3 Mnd1 family PSI_PsaF PF02507.10 AMD19175.1 - 0.071 12.6 9.5 0.53 9.8 0.1 3.0 3 0 0 3 3 3 0 Photosystem I reaction centre subunit III ADIP PF11559.3 AMD19175.1 - 1.4 8.7 103.9 0.048 13.5 8.8 7.6 1 1 5 7 7 7 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.7 AMD19175.1 - 2.5 7.2 29.7 0.088 11.9 4.6 5.2 1 1 4 6 6 6 0 Reovirus sigma C capsid protein APG17 PF04108.7 AMD19176.1 - 0.016 13.9 1.3 0.019 13.7 0.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 MCR_C PF04609.7 AMD19176.1 - 0.036 12.8 0.2 0.049 12.4 0.1 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C LRR_4 PF12799.2 AMD19176.1 - 0.099 12.2 0.4 0.33 10.6 0.1 1.9 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) VHS PF00790.14 AMD19177.1 - 4.3e-45 152.8 0.1 1.3e-44 151.3 0.0 1.8 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.15 AMD19177.1 - 3e-21 75.8 0.1 3e-21 75.8 0.1 2.4 2 0 0 2 2 2 1 Adaptin C-terminal domain GAT PF03127.9 AMD19177.1 - 8.7e-13 48.1 2.4 8.7e-13 48.1 1.7 2.4 2 0 0 2 2 1 1 GAT domain Dehydratase_SU PF02287.10 AMD19177.1 - 0.0067 16.1 0.9 0.016 14.9 0.7 1.7 1 0 0 1 1 1 1 Dehydratase small subunit FHIPEP PF00771.15 AMD19177.1 - 0.037 12.3 3.6 0.068 11.4 2.5 1.3 1 0 0 1 1 1 0 FHIPEP family Med15 PF09606.5 AMD19177.1 - 0.039 12.1 26.3 0.058 11.6 18.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Neur_chan_memb PF02932.11 AMD19177.1 - 0.069 13.0 0.9 0.092 12.6 0.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TMEM51 PF15345.1 AMD19177.1 - 0.1 12.2 11.6 0.19 11.4 8.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 Pex14_N PF04695.8 AMD19177.1 - 0.11 12.5 7.5 0.25 11.3 5.2 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.17 AMD19177.1 - 0.15 11.0 4.9 0.21 10.5 3.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SPARC_Ca_bdg PF10591.4 AMD19177.1 - 1.9 8.5 8.3 0.58 10.2 2.6 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4175 PF13779.1 AMD19177.1 - 1.9 6.1 22.2 4.4 4.8 15.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) OATP PF03137.15 AMD19177.1 - 2.2 6.2 6.2 3.7 5.4 4.3 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family HSA PF07529.8 AMD19178.1 - 2.1e-15 56.2 0.8 1.3e-14 53.6 0.5 2.5 1 0 0 1 1 1 1 HSA Myb_DNA-bind_6 PF13921.1 AMD19178.1 - 2.7e-09 36.9 0.6 2.7e-09 36.9 0.4 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 AMD19178.1 - 0.0066 16.4 0.0 0.021 14.8 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain BCIP PF13862.1 AMD19179.1 - 1.8e-50 171.1 2.3 2.5e-50 170.7 1.6 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein SDA1 PF05285.7 AMD19179.1 - 5.5e-05 22.5 0.0 9.5e-05 21.8 0.0 1.4 1 1 0 1 1 1 1 SDA1 EMP24_GP25L PF01105.19 AMD19181.1 - 4.5e-34 117.7 0.0 5.2e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RIO1 PF01163.17 AMD19182.1 - 1.5e-42 145.1 0.9 2.3e-42 144.5 0.6 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.6 AMD19182.1 - 4.8e-30 103.4 0.1 1.3e-29 102.1 0.0 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.18 AMD19182.1 - 3.1e-08 33.6 0.0 0.0014 18.4 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 AMD19182.1 - 0.00033 19.7 0.2 0.0067 15.5 0.1 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 AMD19182.1 - 0.0012 18.0 0.2 0.0019 17.4 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Rtt106 PF08512.7 AMD19183.1 - 2.7e-29 100.9 1.9 3.4e-29 100.6 0.5 1.9 2 0 0 2 2 2 1 Histone chaperone Rttp106-like ArfGap PF01412.13 AMD19184.1 - 5.2e-33 113.2 0.7 1.2e-32 112.1 0.0 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf adh_short_C2 PF13561.1 AMD19185.1 - 5e-31 108.3 0.1 5.9e-31 108.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 AMD19185.1 - 2e-22 79.8 4.3 2.6e-22 79.4 3.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AMD19185.1 - 3.5e-11 43.0 1.5 5.3e-11 42.4 1.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 AMD19185.1 - 0.15 11.2 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) SMK-1 PF04802.10 AMD19186.1 - 2e-57 193.8 8.4 2e-57 193.8 5.8 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 DUF772 PF05598.6 AMD19186.1 - 0.078 12.8 0.2 0.75 9.7 0.0 2.5 2 0 0 2 2 2 0 Transposase domain (DUF772) YjeF_N PF03853.10 AMD19187.1 - 5.7e-38 130.1 0.0 6.9e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus GOLGA2L5 PF15070.1 AMD19188.1 - 0.01 14.3 1.4 0.01 14.3 1.0 1.5 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Septin PF00735.13 AMD19189.1 - 1.3e-76 257.2 2.6 1.6e-76 256.9 0.0 2.3 2 2 1 3 3 3 1 Septin AAA_33 PF13671.1 AMD19189.1 - 0.0001 22.2 0.1 0.0027 17.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Pox_A32 PF04665.7 AMD19189.1 - 0.0024 17.2 0.2 0.0076 15.5 0.0 1.9 2 0 0 2 2 2 1 Poxvirus A32 protein FtsK_SpoIIIE PF01580.13 AMD19189.1 - 0.0067 15.9 0.1 0.019 14.4 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.1 AMD19189.1 - 0.0067 16.5 0.0 0.034 14.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD19189.1 - 0.0068 17.2 0.1 0.045 14.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 AMD19189.1 - 0.007 16.3 0.0 0.063 13.2 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 AMD19189.1 - 0.011 15.7 0.3 0.029 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.1 AMD19189.1 - 0.014 14.9 0.1 0.033 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 AMD19189.1 - 0.025 14.7 0.2 0.26 11.4 0.0 2.7 2 1 1 3 3 3 0 RNA helicase AIG1 PF04548.11 AMD19189.1 - 0.028 13.5 1.6 0.042 12.9 0.0 2.0 2 0 0 2 2 2 0 AIG1 family AAA_18 PF13238.1 AMD19189.1 - 0.036 14.3 0.1 0.18 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 AMD19189.1 - 0.037 13.2 0.0 0.093 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Sigma54_activat PF00158.21 AMD19189.1 - 0.04 13.4 0.0 0.084 12.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.24 AMD19189.1 - 0.064 13.4 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IncA PF04156.9 AMD19189.1 - 1.1 8.8 9.2 1.9 8.0 6.4 1.4 1 0 0 1 1 1 0 IncA protein AAA_23 PF13476.1 AMD19189.1 - 2.5 8.3 15.2 1.8 8.8 3.7 2.8 2 1 0 2 2 2 0 AAA domain DUF155 PF02582.9 AMD19190.1 - 7.5e-43 146.4 0.6 1.2e-42 145.8 0.4 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 RCC1_2 PF13540.1 AMD19190.1 - 0.12 12.0 0.1 0.3 10.7 0.0 1.6 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat FAD_binding_1 PF00667.15 AMD19191.1 - 2.6e-66 223.2 0.0 4e-66 222.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 AMD19191.1 - 4.3e-30 104.5 0.5 7.8e-30 103.7 0.3 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 AMD19191.1 - 7.9e-24 84.3 0.1 6.2e-23 81.4 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Spore_IV_A PF09547.5 AMD19191.1 - 9.5e-05 21.2 0.0 0.00015 20.5 0.0 1.2 1 0 0 1 1 1 1 Stage IV sporulation protein A (spore_IV_A) Flavodoxin_5 PF12724.2 AMD19191.1 - 0.00096 19.1 0.0 0.0027 17.7 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin domain MAGE PF01454.14 AMD19192.1 - 5e-26 91.2 0.0 6.5e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 MAGE family Minor_capsid_1 PF10665.4 AMD19192.1 - 0.086 12.6 0.2 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 Minor capsid protein DUF836 PF05768.9 AMD19193.1 - 4e-15 55.8 0.5 5e-15 55.5 0.4 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 AMD19193.1 - 0.002 18.0 0.1 0.0034 17.3 0.1 1.6 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.1 AMD19193.1 - 0.033 14.3 0.5 0.045 13.9 0.3 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain DUF217 PF02697.9 AMD19193.1 - 0.093 12.9 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized ACR, COG1753 DELLA PF12041.3 AMD19194.1 - 0.053 13.1 2.3 0.12 12.0 0.1 2.6 2 0 0 2 2 2 0 Transcriptional regulator DELLA protein N terminal Filament PF00038.16 AMD19194.1 - 0.44 9.9 72.4 2.5 7.4 25.0 4.7 1 1 2 3 3 3 0 Intermediate filament protein Peptidase_M4 PF01447.13 AMD19194.1 - 0.63 10.1 9.1 0.27 11.3 1.3 3.0 2 0 0 2 2 2 0 Thermolysin metallopeptidase, catalytic domain PAP2 PF01569.16 AMD19195.1 - 3.6e-21 75.1 2.9 7.7e-21 74.1 2.0 1.4 1 0 0 1 1 1 1 PAP2 superfamily MFS_1 PF07690.11 AMD19195.1 - 0.0076 14.9 0.3 0.0076 14.9 0.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily DsbB PF02600.11 AMD19195.1 - 0.091 12.5 2.7 0.17 11.7 0.2 2.1 2 0 0 2 2 2 0 Disulfide bond formation protein DsbB DUF1430 PF07242.6 AMD19195.1 - 0.35 10.9 2.4 0.93 9.6 1.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1430) HGTP_anticodon2 PF12745.2 AMD19196.1 - 1.6e-94 316.0 1.4 1.6e-94 316.0 1.0 3.2 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Pkinase PF00069.20 AMD19196.1 - 4e-69 232.6 12.5 2.8e-43 147.9 0.2 4.6 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19196.1 - 1.6e-41 142.1 0.7 2.2e-22 79.3 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.17 AMD19196.1 - 4.5e-17 61.9 0.9 4.5e-17 61.9 0.7 2.5 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.1 AMD19196.1 - 3e-15 56.0 0.0 7.6e-15 54.7 0.0 1.7 1 0 0 1 1 1 1 Histidyl-tRNA synthetase Kinase-like PF14531.1 AMD19196.1 - 0.0098 14.8 0.0 0.025 13.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like DUF4407 PF14362.1 AMD19196.1 - 0.018 13.9 4.0 0.032 13.1 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APH PF01636.18 AMD19196.1 - 0.091 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Med20 PF08612.6 AMD19197.1 - 5.9e-49 166.2 0.3 6.5e-49 166.0 0.2 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Lum_binding PF00677.12 AMD19197.1 - 0.048 13.5 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Lumazine binding domain Herpes_U30 PF04523.8 AMD19197.1 - 0.049 11.1 0.3 0.063 10.7 0.2 1.1 1 0 0 1 1 1 0 Herpes virus tegument protein U30 CTD_bind PF04818.8 AMD19198.1 - 1.5e-20 73.2 1.5 1.5e-20 73.2 1.0 2.3 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.3 AMD19198.1 - 0.012 15.2 1.6 0.028 14.0 0.1 2.0 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 AATF-Che1 PF13339.1 AMD19198.1 - 0.27 11.3 7.9 0.18 11.9 3.1 2.4 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor ING PF12998.2 AMD19198.1 - 0.69 10.2 7.0 0.66 10.2 1.6 3.0 2 2 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DEAD PF00270.24 AMD19199.1 - 8.3e-23 80.7 0.0 1.9e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.5 AMD19199.1 - 3e-15 56.5 0.1 9.6e-15 54.9 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) Helicase_C PF00271.26 AMD19199.1 - 6e-12 45.2 0.1 4.3e-11 42.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1344 PF07076.6 AMD19199.1 - 0.075 12.6 0.0 9.5 5.8 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) CDT1 PF08839.6 AMD19199.1 - 0.37 10.7 5.8 1.7 8.6 4.0 2.1 1 1 0 1 1 1 0 DNA replication factor CDT1 like SRP54 PF00448.17 AMD19200.1 - 1.2e-46 158.6 0.1 3.9e-44 150.4 0.1 2.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRX PF09201.5 AMD19200.1 - 1e-43 148.5 0.6 2.6e-43 147.2 0.4 1.7 1 0 0 1 1 1 1 SRX SRP-alpha_N PF04086.8 AMD19200.1 - 4.5e-11 42.6 12.0 1.1e-08 34.7 3.4 2.5 2 0 0 2 2 2 2 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.14 AMD19200.1 - 1.3e-06 28.3 0.9 6.3e-06 26.2 0.4 2.3 1 1 0 1 1 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.18 AMD19200.1 - 2.1e-05 23.9 0.0 6.5e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArgK PF03308.11 AMD19200.1 - 0.00029 19.7 0.1 0.0012 17.7 0.0 2.1 2 1 0 2 2 2 1 ArgK protein MobB PF03205.9 AMD19200.1 - 0.0019 17.9 0.3 0.041 13.5 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ArsA_ATPase PF02374.10 AMD19200.1 - 0.0025 16.9 0.0 0.19 10.7 0.0 2.4 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_22 PF13401.1 AMD19200.1 - 0.0068 16.5 0.0 0.17 12.0 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 AMD19200.1 - 0.014 15.3 0.0 0.042 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Fer4_NifH PF00142.13 AMD19200.1 - 0.04 13.0 0.0 0.079 12.1 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_14 PF13173.1 AMD19200.1 - 0.062 13.1 0.1 1.6 8.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain Response_reg PF00072.19 AMD19200.1 - 0.083 12.8 0.0 0.4 10.7 0.0 2.2 1 0 0 1 1 1 0 Response regulator receiver domain DUF87 PF01935.12 AMD19200.1 - 7.3 6.3 8.1 2.7 7.7 0.2 3.2 4 0 0 4 4 4 0 Domain of unknown function DUF87 Cyt-b5 PF00173.23 AMD19201.1 - 1.7e-13 50.1 0.0 3.5e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 AMD19201.1 - 1.8e-09 37.4 6.9 2.8e-09 36.8 4.8 1.2 1 0 0 1 1 1 1 Fatty acid desaturase zf-HIT PF04438.11 AMD19202.1 - 2.9e-06 26.7 16.7 5.1e-06 26.0 11.5 1.4 1 0 0 1 1 1 1 HIT zinc finger Cwf_Cwc_15 PF04889.7 AMD19202.1 - 0.9 9.1 4.7 1.9 8.1 3.3 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein V-ATPase_G PF03179.10 AMD19203.1 - 6.8e-30 103.4 14.2 7.5e-30 103.3 9.9 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit GTP_cyclohydro2 PF00925.15 AMD19203.1 - 0.028 13.6 2.0 0.65 9.2 0.2 2.1 1 1 1 2 2 2 0 GTP cyclohydrolase II DUF2924 PF11149.3 AMD19203.1 - 0.084 12.8 3.6 0.1 12.6 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) DUF3552 PF12072.3 AMD19203.1 - 0.15 11.2 17.2 0.41 9.8 11.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) GA PF01468.12 AMD19203.1 - 1.2 9.3 11.7 0.35 11.0 3.5 2.5 1 1 1 2 2 2 0 GA module FlgN PF05130.7 AMD19203.1 - 1.3 9.2 9.8 1.6 9.0 6.8 1.1 1 0 0 1 1 1 0 FlgN protein Spore_II_R PF09551.5 AMD19203.1 - 2.5 8.1 4.9 6.9 6.7 3.4 1.6 1 1 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) ATP-synt_B PF00430.13 AMD19203.1 - 5.9 6.7 18.9 40 4.0 13.1 1.9 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Aldedh PF00171.17 AMD19204.1 - 3.6e-122 408.0 0.0 4.5e-122 407.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RRF PF01765.14 AMD19205.1 - 1.9e-39 134.7 3.9 2.7e-39 134.2 2.7 1.2 1 0 0 1 1 1 1 Ribosome recycling factor Mnd1 PF03962.10 AMD19205.1 - 0.022 14.4 4.9 0.024 14.3 1.7 2.1 2 0 0 2 2 2 0 Mnd1 family Tryp_alpha_amyl PF00234.17 AMD19205.1 - 0.059 13.5 0.3 0.096 12.9 0.2 1.5 1 0 0 1 1 1 0 Protease inhibitor/seed storage/LTP family Apolipoprotein PF01442.13 AMD19205.1 - 0.11 11.9 3.8 0.24 10.8 1.5 2.1 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Uds1 PF15456.1 AMD19205.1 - 0.12 12.3 2.2 0.12 12.4 0.4 1.8 2 0 0 2 2 2 0 Up-regulated During Septation NPV_P10 PF05531.7 AMD19205.1 - 0.19 11.9 3.8 0.41 10.9 1.8 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.3 AMD19205.1 - 0.24 11.1 6.6 1.2 8.8 1.7 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Ribosomal_L22 PF00237.14 AMD19205.1 - 0.62 10.0 3.5 0.35 10.8 0.6 1.9 2 1 0 2 2 2 0 Ribosomal protein L22p/L17e TPP_enzyme_M PF00205.17 AMD19206.1 - 4.7e-37 126.7 0.0 1.7e-36 124.9 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.13 AMD19206.1 - 9.9e-34 116.2 0.0 1.7e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 AMD19206.1 - 4.6e-13 49.0 0.0 8e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain RNB PF00773.14 AMD19207.1 - 6.6e-58 196.5 2.5 1.2e-57 195.6 1.8 1.4 1 0 0 1 1 1 1 RNB domain OB_RNB PF08206.6 AMD19207.1 - 4.9e-05 22.7 0.2 0.14 11.6 0.1 2.9 3 0 0 3 3 3 2 Ribonuclease B OB domain DUF572 PF04502.8 AMD19207.1 - 0.001 18.4 0.3 0.001 18.4 0.2 2.4 2 1 0 2 2 2 1 Family of unknown function (DUF572) Aldedh PF00171.17 AMD19208.1 - 6.8e-104 347.7 0.0 7.8e-104 347.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Brr6_like_C_C PF10104.4 AMD19209.1 - 9.3e-42 141.7 0.1 1.4e-41 141.1 0.1 1.3 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain HDA2-3 PF11496.3 AMD19210.1 - 5.5e-72 242.0 0.8 1.3e-71 240.9 0.6 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Mhr1 PF12829.2 AMD19211.1 - 1.4e-35 121.0 0.5 3.5e-35 119.7 0.3 1.7 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination FA_hydroxylase PF04116.8 AMD19212.1 - 5.1e-15 55.8 10.8 5.1e-15 55.8 7.5 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily OSCP PF00213.13 AMD19213.1 - 4.7e-42 143.7 4.8 5.4e-42 143.5 3.3 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit TRAUB PF08164.7 AMD19214.1 - 6.7e-27 93.4 1.2 2e-26 91.8 0.0 2.5 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.1 AMD19214.1 - 2.5e-26 92.3 8.0 2.5e-26 92.3 5.5 3.6 2 1 1 3 3 3 1 Apoptosis antagonizing transcription factor BSP_II PF05432.6 AMD19214.1 - 0.53 9.5 31.1 1.4 8.0 21.6 1.7 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) MatE PF01554.13 AMD19215.1 - 5.3e-50 169.1 24.7 6.8e-26 90.8 4.9 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 AMD19215.1 - 3.3e-09 36.6 5.2 3.3e-09 36.6 3.6 4.4 4 1 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain PIH1 PF08190.7 AMD19216.1 - 5.9e-24 85.1 0.1 7.7e-24 84.7 0.1 1.0 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 AA_kinase PF00696.23 AMD19217.1 - 4e-38 131.3 0.3 5.9e-38 130.7 0.2 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 AMD19217.1 - 1.8e-20 72.4 0.1 3.8e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 PUA domain DUF4224 PF13986.1 AMD19217.1 - 0.026 14.0 0.0 0.077 12.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) CPSF_A PF03178.10 AMD19218.1 - 1.3e-82 277.5 0.4 3.6e-82 276.0 0.1 2.0 2 0 0 2 2 2 1 CPSF A subunit region EPTP PF03736.12 AMD19218.1 - 0.0085 15.8 0.3 8.3 6.2 0.0 3.6 3 0 0 3 3 3 2 EPTP domain PIG-F PF06699.6 AMD19219.1 - 1.4e-40 139.3 19.7 9.7e-40 136.5 13.7 1.9 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F TauE PF01925.14 AMD19219.1 - 0.0052 16.2 1.5 0.0094 15.4 1.0 1.5 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE YfhO PF09586.5 AMD19219.1 - 0.51 8.2 4.4 0.64 7.9 3.1 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO AIM24 PF01987.12 AMD19220.1 - 1.1e-11 44.5 0.1 1.7e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Zn_clus PF00172.13 AMD19221.1 - 2.3e-08 33.8 8.5 4.4e-08 32.9 5.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_60s PF00428.14 AMD19221.1 - 0.044 14.1 0.2 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Pro_isomerase PF00160.16 AMD19222.1 - 1.7e-43 148.5 0.0 2.2e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med6 PF04934.9 AMD19223.1 - 1.8e-54 183.0 0.0 2.3e-54 182.7 0.0 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component CoA_trans PF01144.18 AMD19223.1 - 0.09 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Coenzyme A transferase DUF4620 PF15399.1 AMD19223.1 - 0.23 11.5 1.8 0.44 10.7 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4620) IGR PF09597.5 AMD19224.1 - 1.1e-24 86.0 0.1 1.7e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 IGR protein motif HIT PF01230.18 AMD19225.1 - 1.5e-24 86.3 0.1 2.7e-24 85.5 0.1 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 AMD19225.1 - 1.2e-05 25.5 0.2 1.8e-05 24.9 0.1 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 AMD19225.1 - 0.044 13.4 0.0 0.073 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 LRR_6 PF13516.1 AMD19226.1 - 0.12 12.4 9.4 35 4.9 0.0 6.5 7 0 0 7 7 7 0 Leucine Rich repeat F-box-like PF12937.2 AMD19226.1 - 0.35 10.6 5.7 0.087 12.5 1.1 2.2 2 0 0 2 2 2 0 F-box-like Med21 PF11221.3 AMD19228.1 - 2.6e-43 147.4 0.5 3e-43 147.2 0.4 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex TMCO5 PF14992.1 AMD19228.1 - 0.051 12.6 0.3 0.062 12.4 0.2 1.1 1 0 0 1 1 1 0 TMCO5 family Med9 PF07544.8 AMD19228.1 - 0.062 13.0 0.2 0.35 10.6 0.1 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PBD PF00786.23 AMD19230.1 - 0.0089 16.4 0.1 0.037 14.4 0.0 2.2 1 0 0 1 1 1 1 P21-Rho-binding domain RNase_P_p30 PF01876.11 AMD19231.1 - 4e-44 149.4 0.6 6.2e-44 148.8 0.4 1.3 1 0 0 1 1 1 1 RNase P subunit p30 HTH_20 PF12840.2 AMD19232.1 - 0.14 11.9 0.0 20 5.0 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain ApbA PF02558.11 AMD19233.1 - 8.6e-31 106.4 0.0 1.3e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 AMD19233.1 - 4.4e-26 91.3 0.0 7.2e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal HSP70 PF00012.15 AMD19234.1 - 6e-81 272.1 4.4 5e-80 269.1 1.4 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 AMD19234.1 - 6.1e-12 44.7 0.0 1e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Pox_I6 PF04595.8 AMD19234.1 - 0.017 13.8 0.1 0.062 12.0 0.0 1.9 1 1 1 2 2 2 0 Poxvirus I6-like family BSD PF03909.12 AMD19235.1 - 1.6e-25 88.5 9.1 8.8e-14 50.9 0.4 3.1 3 0 0 3 3 3 2 BSD domain TFIIH_BTF_p62_N PF08567.6 AMD19235.1 - 1.6e-23 82.1 0.2 4e-23 80.8 0.1 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain DEAD PF00270.24 AMD19236.1 - 4.2e-47 159.7 0.1 1.1e-46 158.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19236.1 - 1.6e-26 91.9 0.0 4.1e-26 90.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD19236.1 - 6.3e-06 26.1 0.1 9.5e-05 22.3 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Brix PF04427.13 AMD19237.1 - 3.9e-60 202.7 1.5 5.9e-60 202.2 1.1 1.3 1 0 0 1 1 1 1 Brix domain DUF4207 PF13904.1 AMD19237.1 - 0.0044 16.4 9.0 0.0083 15.5 6.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) ATP-synt_E PF05680.7 AMD19237.1 - 0.84 9.6 10.1 3 7.8 7.0 2.0 1 0 0 1 1 1 0 ATP synthase E chain GAGA_bind PF06217.7 AMD19237.1 - 0.99 9.3 8.8 2 8.3 6.1 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family IncFII_repA PF02387.10 AMD19237.1 - 3.8 6.6 16.2 0.27 10.3 7.4 1.8 2 0 0 2 2 2 0 IncFII RepA protein family Rotamase_2 PF13145.1 AMD19237.1 - 4.8 7.8 15.4 0.44 11.1 6.6 2.2 2 1 0 2 2 2 0 PPIC-type PPIASE domain Atrophin-1 PF03154.10 AMD19237.1 - 9.8 4.1 10.6 15 3.5 7.3 1.2 1 0 0 1 1 1 0 Atrophin-1 family FYVE PF01363.16 AMD19238.1 - 9e-18 63.9 12.3 9e-18 63.9 8.5 3.5 3 1 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.1 AMD19238.1 - 7.5e-09 35.2 3.3 7.5e-09 35.2 2.3 3.9 3 2 1 4 4 4 1 Ring finger domain zf-Apc11 PF12861.2 AMD19238.1 - 0.0067 16.2 3.9 0.011 15.5 0.7 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Ins_P5_2-kin PF06090.7 AMD19240.1 - 4.1e-35 121.3 0.0 8.4e-35 120.2 0.0 1.5 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DS PF01916.12 AMD19241.1 - 2.8e-143 476.4 0.3 3.3e-143 476.2 0.2 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Methyltransf_23 PF13489.1 AMD19242.1 - 5.1e-15 55.5 0.0 8e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD19242.1 - 2.9e-13 49.6 0.3 7.6e-13 48.3 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD19242.1 - 1.3e-12 48.0 0.0 3.5e-12 46.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD19242.1 - 5e-11 42.9 0.0 1.3e-10 41.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD19242.1 - 9.7e-11 42.2 0.0 3.6e-10 40.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD19242.1 - 2.8e-10 40.4 0.0 6.4e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AMD19242.1 - 1.5e-09 37.2 0.1 3.1e-09 36.2 0.1 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 AMD19242.1 - 0.047 13.0 0.0 0.097 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain ECR1_N PF14382.1 AMD19243.1 - 7.9e-14 50.6 0.1 2.8e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 AMD19243.1 - 0.017 15.0 0.0 2.5 8.1 0.0 2.8 3 0 0 3 3 3 0 Exosome component EXOSC1/CSL4 Met_10 PF02475.11 AMD19244.1 - 1.9e-66 223.4 0.0 2.8e-66 222.9 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.10 AMD19244.1 - 0.00083 18.8 0.0 0.002 17.6 0.0 1.6 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase TRM PF02005.11 AMD19244.1 - 0.0023 16.9 2.0 0.011 14.6 0.0 2.7 3 1 0 4 4 4 1 N2,N2-dimethylguanosine tRNA methyltransferase Tenui_N PF05733.6 AMD19244.1 - 0.11 11.7 0.3 0.17 11.1 0.2 1.2 1 0 0 1 1 1 0 Tenuivirus/Phlebovirus nucleocapsid protein Cyclin PF08613.6 AMD19245.1 - 2.6e-10 40.8 0.5 3.3e-10 40.5 0.3 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 AMD19245.1 - 1e-05 25.0 1.8 2.8e-05 23.6 1.2 1.7 1 1 0 1 1 1 1 Cyclin, N-terminal domain Sugar_tr PF00083.19 AMD19246.1 - 2.1e-164 547.4 30.0 2.4e-164 547.2 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD19246.1 - 4.9e-32 111.0 43.3 1.4e-26 93.0 12.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA-synt_1d PF00750.14 AMD19247.1 - 2.8e-103 345.4 7.8 3.5e-103 345.1 5.4 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 AMD19247.1 - 1.6e-29 102.2 0.3 7.2e-29 100.1 0.0 2.2 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 AMD19247.1 - 1.9e-06 28.3 0.1 8.7e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain HTH_25 PF13413.1 AMD19247.1 - 0.19 11.3 1.0 18 5.0 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain Sugar_tr PF00083.19 AMD19248.1 - 7.3e-164 545.6 28.2 8.3e-164 545.4 19.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD19248.1 - 1.5e-31 109.3 29.1 2.9e-26 92.0 13.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LMF1 PF06762.9 AMD19248.1 - 0.026 13.3 1.0 0.042 12.6 0.7 1.4 1 0 0 1 1 1 0 Lipase maturation factor MSP1b PF03429.8 AMD19248.1 - 0.058 11.2 0.3 0.086 10.7 0.2 1.1 1 0 0 1 1 1 0 Major surface protein 1B Sugar_tr PF00083.19 AMD19249.1 - 2.1e-158 527.6 25.7 2.4e-158 527.4 17.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD19249.1 - 1.4e-31 109.5 30.5 4.6e-22 78.2 8.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 AMD19249.1 - 0.00021 19.6 2.1 0.00021 19.6 1.5 2.3 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Cytochrom_B_N PF00033.14 AMD19249.1 - 0.00087 18.6 0.5 0.00087 18.6 0.3 3.3 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Svf1 PF08622.5 AMD19250.1 - 2.2e-120 401.5 1.5 2.6e-120 401.2 1.0 1.0 1 0 0 1 1 1 1 Svf1-like Sod_Fe_C PF02777.13 AMD19251.1 - 6e-10 38.9 0.4 0.00045 20.0 0.0 2.5 2 1 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Pal1 PF08316.6 AMD19252.1 - 1.1e-51 175.0 1.6 1.1e-51 175.0 1.1 2.6 2 1 2 4 4 4 1 Pal1 cell morphology protein Sec23_trunk PF04811.10 AMD19253.1 - 5.3e-54 183.1 0.1 9.6e-54 182.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 AMD19253.1 - 3.2e-18 65.0 0.6 6.6e-18 64.0 0.4 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 AMD19253.1 - 1.2e-13 51.3 0.1 2.9e-13 50.1 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 AMD19253.1 - 6.5e-12 44.8 3.2 1.4e-11 43.7 2.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 AMD19253.1 - 3.1e-05 23.5 0.3 0.00016 21.3 0.0 2.2 2 0 0 2 2 2 1 Gelsolin repeat LIM PF00412.17 AMD19253.1 - 0.047 13.7 1.8 0.12 12.4 1.3 1.8 1 0 0 1 1 1 0 LIM domain Asp PF00026.18 AMD19254.1 - 1.2e-29 103.6 0.3 1.2e-29 103.6 0.2 1.4 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD19254.1 - 0.0044 16.9 0.0 0.064 13.2 0.0 2.7 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal DUF3625 PF12293.3 AMD19254.1 - 0.03 13.4 0.1 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3625) Pribosyltran PF00156.22 AMD19254.1 - 0.031 14.0 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase domain NDUF_B5 PF09781.4 AMD19254.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit AA_permease PF00324.16 AMD19255.1 - 4.9e-128 427.4 33.0 5.5e-128 427.2 22.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD19255.1 - 4.6e-34 117.6 34.4 5.7e-34 117.3 23.9 1.1 1 0 0 1 1 1 1 Amino acid permease Copper-fist PF00649.13 AMD19255.1 - 0.024 13.8 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 Copper fist DNA binding domain EIF_2_alpha PF07541.7 AMD19256.1 - 8.2e-43 144.7 1.4 1.8e-42 143.6 0.3 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 AMD19256.1 - 3.1e-15 55.9 1.7 6.2e-15 55.0 1.1 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Viral_env_E26 PF11050.3 AMD19256.1 - 0.05 12.8 0.2 0.088 11.9 0.2 1.4 1 0 0 1 1 1 0 Virus envelope protein E26 EXOSC1 PF10447.4 AMD19256.1 - 0.053 13.4 0.3 0.16 11.9 0.2 1.9 1 1 0 1 1 1 0 Exosome component EXOSC1/CSL4 Memo PF01875.12 AMD19257.1 - 5.5e-87 291.1 0.0 6.4e-87 290.9 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein ATP-sulfurylase PF01747.12 AMD19258.1 - 3e-87 291.4 0.0 4.1e-87 290.9 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.1 AMD19258.1 - 4.6e-53 178.9 0.0 6.8e-53 178.3 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain Biotin_lipoyl PF00364.17 AMD19259.1 - 2.3e-18 65.5 0.7 5.2e-18 64.4 0.5 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 AMD19259.1 - 0.00019 20.9 0.0 0.00047 19.7 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 AMD19259.1 - 0.046 13.3 0.0 0.15 11.7 0.0 1.9 1 0 0 1 1 1 0 Biotin-lipoyl like QRPTase_N PF02749.11 AMD19259.1 - 0.061 13.1 0.0 6.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain FGGY_N PF00370.16 AMD19260.1 - 3.7e-23 82.1 0.0 1.4e-14 54.0 0.0 2.5 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 AMD19260.1 - 2e-15 56.9 0.0 3.8e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain SPC12 PF06645.8 AMD19261.1 - 2.1e-24 85.1 0.3 2.4e-24 84.9 0.2 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF3278 PF11683.3 AMD19261.1 - 0.023 14.6 0.5 0.03 14.3 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) DUF4600 PF15372.1 AMD19262.1 - 0.081 13.1 0.3 1.3 9.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) Candida_ALS_N PF11766.3 AMD19263.1 - 1.3e-50 171.6 2.2 1.6e-50 171.3 1.6 1.1 1 0 0 1 1 1 1 Cell-wall agglutinin N-terminal ligand-sugar binding YecM PF06185.7 AMD19263.1 - 0.18 11.0 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 YecM protein PI-PLC-X PF00388.14 AMD19265.1 - 1.7e-19 69.6 0.0 4.5e-19 68.2 0.0 1.7 2 1 1 3 3 3 1 Phosphatidylinositol-specific phospholipase C, X domain ThuA PF06283.6 AMD19265.1 - 0.00029 20.6 0.0 0.00059 19.6 0.0 1.5 1 0 0 1 1 1 1 Trehalose utilisation Sld5 PF05916.6 AMD19266.1 - 7.4e-18 64.8 0.1 1.2e-17 64.0 0.1 1.3 1 0 0 1 1 1 1 GINS complex protein DUF619 PF04768.8 AMD19267.1 - 2.7e-46 157.0 0.0 6.5e-46 155.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF619) A_deaminase PF00962.17 AMD19268.1 - 1e-12 47.6 0.0 2.1e-07 30.1 0.0 3.0 3 1 0 3 3 3 2 Adenosine/AMP deaminase Myb_DNA-binding PF00249.26 AMD19269.1 - 1.4e-23 82.6 1.4 7.5e-13 48.3 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD19269.1 - 5e-20 71.3 2.5 2.3e-14 53.2 0.1 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Tim54 PF11711.3 AMD19270.1 - 1.3e-118 395.8 0.8 1.1e-79 267.7 0.1 2.0 1 1 1 2 2 2 2 Inner membrane protein import complex subunit Tim54 Vps26 PF03643.10 AMD19271.1 - 5.1e-113 376.4 1.6 5.8e-113 376.2 1.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 AMD19271.1 - 8.2e-06 25.7 0.7 0.00015 21.6 0.3 2.7 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 AMD19271.1 - 0.024 14.7 0.4 0.22 11.6 0.1 2.4 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain COX3 PF00510.13 AMD19271.1 - 0.054 12.9 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit III Pkinase PF00069.20 AMD19272.1 - 4.3e-42 144.0 0.0 5.5e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19272.1 - 5.7e-21 74.7 0.0 6.8e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 AMD19272.1 - 5.9e-06 25.7 0.2 9e-06 25.1 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 AMD19272.1 - 0.00077 18.5 0.0 0.0011 17.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD19272.1 - 0.0022 17.7 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family rRNA_proc-arch PF13234.1 AMD19274.1 - 9.6e-89 297.0 1.1 2e-88 296.0 0.8 1.6 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 AMD19274.1 - 3e-64 215.5 0.2 8e-64 214.1 0.1 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 AMD19274.1 - 1.1e-21 77.0 0.0 6.4e-21 74.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19274.1 - 2.9e-06 27.0 0.0 7.5e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Snf7 PF03357.16 AMD19276.1 - 3.8e-16 58.9 16.1 6.2e-16 58.2 11.2 1.3 1 0 0 1 1 1 1 Snf7 Prefoldin_2 PF01920.15 AMD19276.1 - 0.016 14.9 13.2 3.4 7.4 0.0 3.0 2 1 0 2 2 2 0 Prefoldin subunit APG6 PF04111.7 AMD19276.1 - 0.17 10.8 12.9 0.48 9.4 5.0 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 Snapin_Pallidin PF14712.1 AMD19276.1 - 0.73 10.1 15.0 0.07 13.4 2.5 3.1 3 1 0 3 3 3 0 Snapin/Pallidin DivIC PF04977.10 AMD19276.1 - 1.1 8.8 16.2 0.49 9.9 0.1 3.6 2 1 1 3 3 3 0 Septum formation initiator DUF3422 PF11902.3 AMD19276.1 - 3.8 6.2 9.1 2.5 6.8 1.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3422) Maf1 PF09174.5 AMD19276.1 - 5.9 6.6 8.0 0.42 10.4 0.1 2.5 3 0 0 3 3 3 0 Maf1 regulator UBX PF00789.15 AMD19277.1 - 1.1e-17 63.8 0.0 2.5e-17 62.6 0.0 1.7 1 0 0 1 1 1 1 UBX domain Pkinase PF00069.20 AMD19278.1 - 3.7e-58 196.7 0.0 5e-58 196.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19278.1 - 8.5e-34 116.7 0.0 1.4e-33 116.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19278.1 - 1.1e-07 31.1 0.0 2.3e-07 30.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 AMD19278.1 - 0.092 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 AMD19278.1 - 0.099 11.6 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rif1_N PF12231.3 AMD19279.1 - 2.2e-36 125.6 12.4 3.7e-36 124.8 7.5 2.1 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal Ras PF00071.17 AMD19280.1 - 1.4e-39 135.0 0.2 7.1e-39 132.7 0.2 1.9 1 1 0 1 1 1 1 Ras family Miro PF08477.8 AMD19280.1 - 5.1e-16 59.2 0.2 7.7e-16 58.6 0.1 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD19280.1 - 2.3e-14 53.0 0.8 2e-13 49.9 0.5 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 AMD19280.1 - 1.6e-07 31.2 0.1 2.2e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 AMD19280.1 - 6.4e-07 28.7 0.0 9.2e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 AMD19280.1 - 0.00038 19.7 0.0 0.00066 18.9 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 AMD19280.1 - 0.0019 17.6 0.1 0.0094 15.4 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 AMD19280.1 - 0.03 13.5 0.2 0.077 12.1 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF258 Septin PF00735.13 AMD19280.1 - 0.053 12.5 0.1 0.085 11.8 0.0 1.3 1 0 0 1 1 1 0 Septin G-alpha PF00503.15 AMD19280.1 - 0.064 11.9 1.1 2.8 6.5 0.1 2.2 1 1 1 2 2 2 0 G-protein alpha subunit SHMT PF00464.14 AMD19281.1 - 1.1e-202 672.7 0.0 1.5e-202 672.2 0.0 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.16 AMD19281.1 - 0.00067 18.7 0.0 0.0011 17.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II zf-H2C2_2 PF13465.1 AMD19282.1 - 9.8e-32 107.6 37.4 1.8e-09 37.3 0.8 6.4 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.21 AMD19282.1 - 1.3e-23 81.8 54.3 3e-06 27.2 1.7 8.7 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD19282.1 - 2.9e-18 64.7 51.1 0.00027 21.0 0.8 9.4 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AMD19282.1 - 1.5e-11 44.0 30.4 0.00047 20.2 0.6 7.5 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 AMD19282.1 - 5.5e-10 38.7 36.0 0.00025 20.8 0.1 7.6 6 1 1 7 7 7 4 C2H2-type zinc finger zf-met PF12874.2 AMD19282.1 - 3.7e-08 33.3 32.0 0.025 14.7 0.6 6.9 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.1 AMD19282.1 - 0.00014 21.4 18.4 0.76 9.5 0.1 5.7 5 0 0 5 5 5 3 zinc-finger of a C2HC-type zf-CHCC PF10276.4 AMD19282.1 - 0.012 15.4 5.3 0.99 9.3 0.2 3.8 3 0 0 3 3 3 0 Zinc-finger domain UreD PF01774.12 AMD19282.1 - 0.044 13.2 0.0 1.8 8.0 0.0 2.2 2 0 0 2 2 2 0 UreD urease accessory protein zf-BED PF02892.10 AMD19282.1 - 0.2 11.4 23.6 0.099 12.4 2.2 4.3 1 1 3 4 4 4 0 BED zinc finger Pkinase PF00069.20 AMD19283.1 - 8.7e-34 116.8 0.0 5e-33 114.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19283.1 - 1.6e-19 70.0 0.0 9.1e-19 67.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase HbrB PF08539.6 AMD19284.1 - 8e-31 107.0 0.1 1.6e-30 106.0 0.1 1.4 1 0 0 1 1 1 1 HbrB-like CLN3 PF02487.12 AMD19285.1 - 1.5e-122 409.2 20.7 5.1e-121 404.2 14.4 2.0 1 1 0 1 1 1 1 CLN3 protein Aminotran_1_2 PF00155.16 AMD19286.1 - 4.8e-71 239.6 0.0 5.6e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 AMD19286.1 - 0.0014 17.7 0.0 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 AMD19286.1 - 0.012 13.9 0.0 0.024 12.9 0.0 1.4 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF1674 PF07896.7 AMD19287.1 - 1.8e-16 60.0 2.1 1.4e-15 57.1 1.4 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Nup88 PF10168.4 AMD19288.1 - 0.00045 18.2 0.0 0.00045 18.2 0.0 1.9 2 0 0 2 2 2 1 Nuclear pore component WD40 PF00400.27 AMD19288.1 - 0.056 13.3 0.0 0.63 10.0 0.0 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat Ribosomal_L37 PF08561.5 AMD19289.1 - 2.8e-26 90.9 0.4 3.4e-26 90.6 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 Phosphodiest PF01663.17 AMD19290.1 - 4.3e-16 59.1 1.0 9.4e-15 54.7 0.7 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 AMD19290.1 - 5.1e-05 22.7 0.1 9.6e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 AMD19290.1 - 0.037 13.2 0.0 0.12 11.4 0.0 1.8 2 0 0 2 2 2 0 Sulfatase zf-C2H2_2 PF12756.2 AMD19291.1 - 1.4e-33 115.0 12.2 2.4e-33 114.2 0.9 3.1 4 0 0 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 AMD19291.1 - 0.16 12.1 2.3 0.29 11.3 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 AMD19291.1 - 0.28 11.5 0.2 0.28 11.5 0.2 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type AAA_11 PF13086.1 AMD19291.1 - 1.6 8.2 6.7 0.81 9.2 2.8 1.8 2 0 0 2 2 2 0 AAA domain adh_short PF00106.20 AMD19292.1 - 6.3e-21 75.0 0.1 8.4e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AMD19292.1 - 8.9e-17 61.3 0.1 1.2e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 AMD19292.1 - 0.0002 21.2 0.0 0.00028 20.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 AMD19292.1 - 0.0013 18.7 0.0 0.032 14.2 0.0 2.3 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 AMD19292.1 - 0.004 16.0 0.0 0.0056 15.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 AMD19292.1 - 0.011 15.4 0.0 1.8 8.3 0.0 2.6 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 AMD19292.1 - 0.013 14.9 0.1 0.03 13.7 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 AMD19292.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Ribosomal_L17 PF01196.14 AMD19294.1 - 1.7e-27 95.8 0.9 3e-25 88.6 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L17 POTRA_2 PF08479.6 AMD19294.1 - 0.039 13.6 0.5 2.7 7.7 0.1 2.7 3 0 0 3 3 3 0 POTRA domain, ShlB-type HTH_39 PF14090.1 AMD19294.1 - 0.05 13.0 0.1 0.16 11.4 0.1 1.8 1 1 0 1 1 1 0 Helix-turn-helix domain PALP PF00291.20 AMD19295.1 - 3.5e-57 193.9 0.0 4e-57 193.7 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DSPc PF00782.15 AMD19296.1 - 1.4e-26 92.6 0.7 1.8e-21 76.0 0.2 3.4 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 AMD19296.1 - 1.4e-08 34.4 0.1 4.9e-07 29.3 0.1 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 AMD19296.1 - 0.0012 18.3 0.5 0.025 14.0 0.0 2.6 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 AMD19296.1 - 0.0095 15.9 0.1 0.028 14.4 0.1 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate CBFD_NFYB_HMF PF00808.18 AMD19297.1 - 0.00011 22.2 0.3 0.00011 22.2 0.2 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone BUD22 PF09073.5 AMD19297.1 - 0.008 15.2 2.6 0.0088 15.1 1.8 1.2 1 0 0 1 1 1 1 BUD22 Histone PF00125.19 AMD19297.1 - 0.073 13.1 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Paf1 PF03985.8 AMD19299.1 - 5e-141 470.3 16.8 5.6e-141 470.2 11.6 1.0 1 0 0 1 1 1 1 Paf1 DUF445 PF04286.7 AMD19299.1 - 0.13 11.7 2.5 0.37 10.2 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Esterase PF00756.15 AMD19300.1 - 1.5e-57 194.9 0.1 1.7e-57 194.7 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 AMD19300.1 - 5.4e-05 22.9 0.0 8.6e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 AMD19300.1 - 0.0043 16.3 0.0 0.007 15.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 AMD19300.1 - 0.01 14.7 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Lipase_3 PF01764.20 AMD19300.1 - 0.098 12.2 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) RCC1_2 PF13540.1 AMD19301.1 - 2.6e-16 58.7 6.4 6.7e-08 31.9 0.1 4.6 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 AMD19301.1 - 1.6e-13 50.6 0.0 0.00013 22.1 0.1 6.2 5 1 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.2 AMD19301.1 - 0.00025 20.7 0.0 0.00047 19.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like MTS PF05175.9 AMD19301.1 - 0.0054 16.1 0.0 0.066 12.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Peptidase_M20 PF01546.23 AMD19302.1 - 1.5e-21 76.7 0.0 2.5e-21 76.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 AMD19302.1 - 5.7e-12 45.3 0.0 9.5e-12 44.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.27 AMD19302.1 - 7e-08 32.0 10.8 0.0057 16.4 0.0 6.2 6 0 0 6 6 6 2 WD domain, G-beta repeat WD40 PF00400.27 AMD19303.1 - 2.8e-13 49.1 0.1 0.00012 21.7 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat Apc4_WD40 PF12894.2 AMD19303.1 - 0.02 14.3 0.0 0.61 9.6 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain MRP-L27 PF09809.4 AMD19304.1 - 6.2e-28 96.6 0.4 1e-27 95.9 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Cullin PF00888.17 AMD19305.1 - 8.5e-07 27.8 7.4 4.5e-06 25.5 3.8 2.8 1 1 1 2 2 2 1 Cullin family DUF4298 PF14131.1 AMD19305.1 - 2.4 8.0 6.7 1.8 8.4 0.4 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4298) RhoGAP PF00620.22 AMD19306.1 - 8.6e-40 135.8 0.0 1.8e-39 134.7 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.18 AMD19306.1 - 5.8e-10 39.2 0.5 1.6e-09 37.8 0.1 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain CHIPS PF11434.3 AMD19306.1 - 0.14 11.8 1.5 0.45 10.1 0.1 2.6 3 0 0 3 3 3 0 Chemotaxis-inhibiting protein CHIPS IncA PF04156.9 AMD19306.1 - 7.6 6.0 11.8 8.1 5.9 2.2 2.3 1 1 1 2 2 2 0 IncA protein Methyltransf_PK PF05891.7 AMD19307.1 - 1e-88 296.3 0.0 1.2e-88 296.1 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_18 PF12847.2 AMD19307.1 - 1.4e-06 28.8 0.0 2.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD19307.1 - 4.4e-05 23.2 0.0 6.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD19307.1 - 0.0001 22.6 0.0 0.00018 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD19307.1 - 0.00036 20.9 0.0 0.00065 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 AMD19307.1 - 0.02 14.1 0.0 0.042 13.0 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_12 PF08242.7 AMD19307.1 - 0.073 13.5 0.0 0.2 12.1 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain SecY PF00344.15 AMD19309.1 - 1.1e-51 175.8 20.2 1.4e-51 175.4 14.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 AMD19309.1 - 2.8e-08 33.1 0.0 9e-08 31.4 0.0 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p COMPASS-Shg1 PF05205.7 AMD19311.1 - 7.2e-21 74.4 5.9 9e-21 74.1 4.1 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 DUF1792 PF08759.6 AMD19311.1 - 0.024 14.2 0.4 0.37 10.3 0.0 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF1792) YtzH PF14165.1 AMD19311.1 - 0.1 12.8 5.3 0.11 12.7 0.3 2.3 2 1 0 2 2 2 0 YtzH-like protein UPF0086 PF01868.11 AMD19312.1 - 2.1e-12 46.5 0.0 3.5e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 BPL_LplA_LipB PF03099.14 AMD19313.1 - 1.1e-18 67.4 0.0 1.9e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DLD PF14878.1 AMD19314.1 - 0.032 14.3 0.1 9.8 6.3 0.0 2.2 1 1 1 2 2 2 0 Death-like domain of SPT6 Flocculin_t3 PF13928.1 AMD19315.1 - 2.5e-07 30.7 34.3 6.4e-05 23.0 6.4 6.1 4 1 0 4 4 4 2 Flocculin type 3 repeat DUF1510 PF07423.6 AMD19316.1 - 0.097 12.0 5.5 0.18 11.1 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TRAP_alpha PF03896.11 AMD19316.1 - 2.8 6.8 12.0 5.3 5.9 8.3 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RNA_pol_3_Rpc31 PF11705.3 AMD19316.1 - 5.1 6.9 25.2 9.8 6.0 17.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Peptidase_M28 PF04389.12 AMD19317.1 - 3.4e-32 111.6 0.0 7e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 AMD19317.1 - 8.2e-13 47.9 0.0 1.6e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M42 PF05343.9 AMD19317.1 - 9.1e-05 21.3 0.0 0.00021 20.1 0.0 1.5 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.23 AMD19317.1 - 0.0015 18.1 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DnaJ PF00226.26 AMD19318.1 - 4.5e-19 67.9 6.5 4.5e-19 67.9 4.5 2.5 3 0 0 3 3 3 1 DnaJ domain Mem_trans PF03547.13 AMD19319.1 - 1.5e-55 188.1 10.5 6.3e-55 186.0 7.3 1.7 1 1 0 1 1 1 1 Membrane transport protein DUF485 PF04341.7 AMD19319.1 - 0.24 11.1 3.4 2.2 8.0 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function, DUF485 B12D PF06522.6 AMD19319.1 - 9.8 5.9 6.5 1.4 8.6 0.5 2.4 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit SMC_N PF02463.14 AMD19320.1 - 2.5e-49 167.4 55.7 9.8e-49 165.5 38.6 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 AMD19320.1 - 5.8e-28 97.2 1.9 1.3e-27 96.0 0.0 2.8 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 AMD19320.1 - 2.7e-15 57.2 8.0 2.7e-15 57.2 5.5 7.6 2 2 3 5 5 5 1 AAA domain AAA_21 PF13304.1 AMD19320.1 - 5e-10 39.8 17.4 6.1e-07 29.6 0.2 3.5 2 1 0 3 3 3 2 AAA domain AAA_29 PF13555.1 AMD19320.1 - 0.0046 16.4 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain BLOC1_2 PF10046.4 AMD19320.1 - 0.0059 16.7 5.4 0.0059 16.7 3.8 10.2 7 3 5 12 12 12 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 MtrB PF05440.7 AMD19320.1 - 6.8 6.8 9.2 8.2 6.5 0.2 4.4 3 1 1 4 4 4 0 Tetrahydromethanopterin S-methyltransferase subunit B Cytokin_check_N PF10407.4 AMD19321.1 - 7.2e-30 102.4 3.4 1.4e-29 101.5 1.6 2.1 2 0 0 2 2 2 1 Cdc14 phosphatase binding protein N-terminus EF-hand_8 PF13833.1 AMD19322.1 - 0.15 11.6 0.0 2.8 7.6 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair CAP PF00188.21 AMD19323.1 - 9.7e-19 68.0 0.1 1.6e-18 67.3 0.1 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PAT1 PF09770.4 AMD19323.1 - 0.61 8.2 15.6 0.72 8.0 10.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CAP PF00188.21 AMD19324.1 - 3.7e-22 79.1 4.2 5.2e-22 78.6 2.9 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SEA PF01390.15 AMD19324.1 - 0.031 13.9 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 SEA domain KH_1 PF00013.24 AMD19325.1 - 2.7e-65 215.8 30.7 3.7e-11 42.4 0.2 11.3 12 0 0 12 12 12 9 KH domain KH_3 PF13014.1 AMD19325.1 - 1.7e-32 110.4 19.9 3e-06 26.7 0.1 9.6 9 0 0 9 9 9 6 KH domain KH_2 PF07650.12 AMD19325.1 - 3.6e-08 32.8 7.4 0.0026 17.2 0.3 4.8 4 0 0 4 4 4 2 KH domain KH_4 PF13083.1 AMD19325.1 - 7.1e-06 25.5 0.2 0.22 11.1 0.0 4.6 4 0 0 4 4 4 2 KH domain BMC PF00936.14 AMD19325.1 - 0.00023 20.7 1.1 3.8 7.2 0.1 5.8 8 0 0 8 8 8 1 BMC domain SLS PF14611.1 AMD19325.1 - 0.0012 18.3 14.1 1.2 8.4 0.1 6.6 5 1 0 7 7 7 2 Mitochondrial inner-membrane-bound regulator Alba PF01918.16 AMD19325.1 - 0.015 14.8 2.5 0.73 9.4 0.2 4.1 4 0 0 4 4 4 0 Alba KH_5 PF13184.1 AMD19325.1 - 0.078 12.7 12.0 0.53 10.1 0.1 5.1 5 0 0 5 5 5 0 NusA-like KH domain Ras PF00071.17 AMD19326.1 - 1.2e-53 180.8 0.2 1.4e-53 180.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD19326.1 - 1e-19 71.1 0.1 2.1e-19 70.1 0.1 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD19326.1 - 6e-14 51.6 0.1 8e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 AMD19326.1 - 1.4e-05 24.4 0.1 2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 AMD19326.1 - 7.2e-05 22.7 0.0 0.00012 21.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD19326.1 - 0.0004 19.8 0.1 0.00093 18.6 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 AMD19326.1 - 0.053 12.7 0.1 0.13 11.4 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 AMD19326.1 - 0.081 12.8 0.1 0.17 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.15 AMD19326.1 - 0.12 10.9 0.3 2.9 6.4 0.0 2.5 1 1 1 2 2 2 0 G-protein alpha subunit Mitofilin PF09731.4 AMD19327.1 - 9.5e-100 334.9 21.6 1.2e-87 294.9 14.3 2.0 1 1 1 2 2 2 2 Mitochondrial inner membrane protein Prp18 PF02840.10 AMD19327.1 - 0.031 14.1 0.7 0.031 14.1 0.5 2.5 1 1 1 2 2 2 0 Prp18 domain OmpH PF03938.9 AMD19327.1 - 0.16 11.9 15.1 0.37 10.7 10.5 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SseC PF04888.7 AMD19327.1 - 0.18 11.0 8.0 0.32 10.2 5.5 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Pepsin-I3 PF06394.8 AMD19327.1 - 2.4 7.8 7.5 0.95 9.1 2.6 2.2 1 1 1 2 2 2 0 Pepsin inhibitor-3-like repeated domain MitMem_reg PF13012.1 AMD19327.1 - 3.1 7.9 14.0 0.15 12.1 3.0 3.0 2 1 2 4 4 4 0 Maintenance of mitochondrial structure and function DUF1104 PF06518.6 AMD19327.1 - 4.7 7.4 15.2 3.8 7.6 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1104) Actin PF00022.14 AMD19328.1 - 7.9e-95 317.5 0.0 7.3e-94 314.3 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 AMD19328.1 - 0.0097 14.5 0.0 0.24 9.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein IBR PF01485.16 AMD19329.1 - 9.4e-17 60.6 38.8 3.3e-09 36.4 7.6 3.7 3 0 0 3 3 3 2 IBR domain zf-C3HC4 PF00097.20 AMD19329.1 - 0.0012 18.5 10.6 0.0012 18.5 7.3 5.2 4 1 1 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD19329.1 - 0.0016 18.3 11.8 0.0016 18.3 8.2 4.5 4 1 1 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 AMD19329.1 - 0.28 11.0 40.1 0.24 11.2 7.4 4.3 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING EF-hand_4 PF12763.2 AMD19330.1 - 2.3e-05 24.0 0.1 5.1e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.1 AMD19330.1 - 0.024 14.2 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair Vps51 PF08700.6 AMD19331.1 - 1.9e-13 50.0 6.9 2.2e-13 49.8 1.8 2.1 2 0 0 2 2 2 1 Vps51/Vps67 HBS1_N PF08938.5 AMD19331.1 - 0.068 13.3 1.1 0.12 12.5 0.7 1.5 1 1 0 1 1 1 0 HBS1 N-terminus DUF2205 PF10224.4 AMD19331.1 - 0.069 12.7 1.4 0.44 10.1 0.3 2.3 2 1 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) DUF4407 PF14362.1 AMD19331.1 - 0.15 10.9 1.8 0.17 10.8 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Arrestin_C PF02752.17 AMD19332.1 - 1.2e-17 64.2 0.1 5.7e-15 55.6 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 AMD19332.1 - 3.6e-09 36.6 0.0 1.7e-05 24.7 0.0 3.3 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Exo70 PF03081.10 AMD19333.1 - 1.2e-90 303.9 4.1 1.2e-90 303.9 2.8 1.6 2 0 0 2 2 2 1 Exo70 exocyst complex subunit phiKZ_IP PF12699.2 AMD19333.1 - 0.013 14.4 6.8 0.61 8.9 0.1 3.2 3 0 0 3 3 3 0 phiKZ-like phage internal head proteins HMA PF00403.21 AMD19333.1 - 2.2 8.4 5.0 0.54 10.4 0.2 2.3 3 0 0 3 3 3 0 Heavy-metal-associated domain RNA_lig_T4_1 PF09511.5 AMD19334.1 - 3.4e-81 271.9 0.6 1.2e-80 270.1 0.1 2.1 2 0 0 2 2 2 1 RNA ligase tRNA_lig_kinase PF08303.6 AMD19334.1 - 1e-72 243.4 0.6 2.2e-72 242.3 0.1 1.8 2 0 0 2 2 2 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.6 AMD19334.1 - 1.3e-59 201.5 2.2 2e-59 200.9 1.5 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain PRK PF00485.13 AMD19334.1 - 0.013 15.0 0.6 0.028 13.9 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family OTCace PF00185.19 AMD19335.1 - 4.5e-44 150.0 0.9 8.5e-44 149.2 0.6 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.16 AMD19335.1 - 2.1e-42 144.1 0.5 1.4e-41 141.4 0.3 2.1 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Dynein_light PF01221.13 AMD19335.1 - 0.087 12.8 1.4 1.1 9.3 0.0 2.9 3 0 0 3 3 3 0 Dynein light chain type 1 NTR2 PF15458.1 AMD19336.1 - 7.2e-22 77.8 18.4 7.2e-22 77.8 12.8 2.2 1 1 1 2 2 2 2 Nineteen complex-related protein 2 Zn_clus PF00172.13 AMD19337.1 - 1.2e-10 41.1 11.5 2.1e-10 40.3 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BRCT PF00533.21 AMD19338.1 - 1.6e-14 53.7 0.8 0.0041 17.2 0.0 4.7 4 0 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 AMD19338.1 - 2.7e-07 30.3 0.8 0.00088 19.0 0.0 3.7 3 0 0 3 3 3 2 twin BRCT domain GWT1 PF06423.7 AMD19339.1 - 1e-40 138.9 7.6 1e-40 138.9 5.3 2.2 2 1 0 2 2 2 1 GWT1 UvrD_C PF13361.1 AMD19340.1 - 1e-68 232.4 0.6 6.2e-40 137.7 0.5 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 AMD19340.1 - 5.4e-61 206.6 0.0 5.4e-61 206.6 0.0 2.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.1 AMD19340.1 - 1.9e-09 37.1 0.1 4.2e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 AMD19340.1 - 3.7e-09 36.6 0.2 0.00013 22.0 0.0 3.2 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.1 AMD19340.1 - 0.0027 17.3 0.0 0.008 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 AMD19340.1 - 0.003 16.9 0.1 0.035 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 AMD19340.1 - 0.034 13.6 1.3 13 5.2 0.0 3.9 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.9 AMD19340.1 - 0.035 13.7 0.0 0.093 12.3 0.0 1.7 1 0 0 1 1 1 0 Helicase Pkinase PF00069.20 AMD19341.1 - 4.2e-66 222.7 0.0 7.7e-66 221.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19341.1 - 2.1e-44 151.5 0.0 3.7e-44 150.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19341.1 - 1.7e-08 33.7 0.0 3.7e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SAM_2 PF07647.12 AMD19341.1 - 0.011 15.5 0.3 0.025 14.4 0.2 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) APH PF01636.18 AMD19341.1 - 0.037 13.7 0.0 0.068 12.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 AMD19341.1 - 0.076 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_1 PF00536.25 AMD19341.1 - 0.11 12.6 0.6 0.24 11.6 0.4 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ribosomal_L21p PF00829.16 AMD19342.1 - 0.00021 21.3 0.0 0.0003 20.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein PTPLA PF04387.9 AMD19343.1 - 1.4e-44 151.3 7.0 1.4e-44 151.3 4.8 1.9 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA Tox-WTIP PF15654.1 AMD19343.1 - 0.026 14.1 0.0 0.061 12.9 0.0 1.6 1 0 0 1 1 1 0 Toxin with a conserved tryptophan and TIP tripeptide motif SAPS PF04499.10 AMD19344.1 - 1.9e-175 584.0 0.0 1.9e-175 584.0 0.0 3.6 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein DUF1127 PF06568.6 AMD19344.1 - 0.15 11.4 0.2 0.33 10.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) ChAPs PF09295.5 AMD19345.1 - 2.5e-48 164.8 1.0 1.6e-41 142.4 0.0 2.3 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 AMD19345.1 - 1.9e-10 40.2 0.0 8.9e-06 25.2 0.0 2.6 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.1 AMD19345.1 - 8.1e-07 29.5 0.0 0.00099 19.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 AMD19345.1 - 6e-06 26.4 0.3 0.061 13.9 0.0 3.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 AMD19345.1 - 2.3e-05 23.9 0.4 0.05 13.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 AMD19345.1 - 6e-05 22.4 0.6 0.041 13.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 AMD19345.1 - 6.2e-05 22.8 0.1 0.033 14.3 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 AMD19345.1 - 0.00042 20.3 3.6 0.14 12.3 0.0 3.4 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 AMD19345.1 - 0.00044 19.8 0.0 0.022 14.4 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 AMD19345.1 - 0.00057 19.7 0.1 0.64 9.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 AMD19345.1 - 0.00068 19.4 0.1 1.4 8.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD19345.1 - 0.0019 17.8 0.5 0.38 10.6 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 AMD19345.1 - 0.002 18.4 0.5 0.44 10.9 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat PI3_PI4_kinase PF00454.22 AMD19346.1 - 8.9e-58 195.5 0.1 1.2e-57 195.0 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase GCS PF03074.11 AMD19347.1 - 5e-139 463.4 0.8 6.2e-139 463.1 0.6 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.8 AMD19347.1 - 0.0081 15.2 0.1 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Glutamate-cysteine ligase family 2(GCS2) GTP_EFTU PF00009.22 AMD19348.1 - 7.3e-58 195.1 0.0 1.6e-57 194.0 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 AMD19348.1 - 2.1e-27 94.7 0.3 4.8e-27 93.6 0.0 1.8 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_C PF00679.19 AMD19348.1 - 1.2e-14 53.8 0.1 4.7e-07 29.5 0.0 2.6 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 AMD19348.1 - 1.6e-07 31.3 0.6 4.7e-07 29.8 0.4 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AMD19348.1 - 0.0079 16.1 0.1 0.023 14.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 AMD19348.1 - 0.048 14.1 0.2 0.32 11.5 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein ANP PF00212.13 AMD19348.1 - 0.084 12.9 0.1 0.86 9.7 0.0 2.3 2 0 0 2 2 2 0 Atrial natriuretic peptide IF-2B PF01008.12 AMD19349.1 - 2.1e-73 246.7 0.0 2.3e-73 246.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Sin_N PF04801.8 AMD19350.1 - 1.5e-20 73.4 0.2 2.6e-20 72.7 0.2 1.3 1 1 0 1 1 1 1 Sin-like protein conserved region DEAD PF00270.24 AMD19351.1 - 1.1e-38 132.3 0.0 1.7e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19351.1 - 1.9e-18 66.0 0.0 4.3e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 AMD19351.1 - 5.9e-17 60.9 0.3 1.7e-16 59.4 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.10 AMD19351.1 - 0.0023 17.7 0.0 0.0052 16.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zn_clus PF00172.13 AMD19352.1 - 5.1e-07 29.5 11.0 9.5e-07 28.6 7.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.19 AMD19352.1 - 8.6e-05 22.2 0.0 0.00019 21.1 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.1 AMD19352.1 - 0.14 12.0 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 PAS domain zf-C2HC5 PF06221.8 AMD19353.1 - 7.2e-22 76.9 4.4 1.3e-21 76.0 3.1 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DUF2393 PF09624.5 AMD19353.1 - 0.0018 17.8 0.0 0.0039 16.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2393) Wzz PF02706.10 AMD19353.1 - 0.0044 16.8 0.7 0.012 15.4 0.5 1.7 1 0 0 1 1 1 1 Chain length determinant protein zf-CCCH PF00642.19 AMD19354.1 - 0.0098 15.5 4.6 0.0098 15.5 3.2 4.1 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Toxin_7 PF05980.7 AMD19354.1 - 7.1 6.7 9.2 0.14 12.2 1.3 2.0 2 0 0 2 2 2 0 Toxin 7 Pam16 PF03656.8 AMD19355.1 - 2.3e-44 150.2 0.7 2.6e-44 150.0 0.5 1.0 1 0 0 1 1 1 1 Pam16 PHD PF00628.24 AMD19356.1 - 2.4e-10 39.9 7.0 5.4e-10 38.8 4.8 1.7 1 0 0 1 1 1 1 PHD-finger MIP-T3 PF10243.4 AMD19356.1 - 3.5e-06 25.7 21.1 3.5e-06 25.7 14.6 3.1 3 0 0 3 3 3 1 Microtubule-binding protein MIP-T3 SET PF00856.23 AMD19356.1 - 4.1e-06 27.1 0.0 4.1e-06 27.1 0.0 3.7 4 1 0 4 4 4 1 SET domain PHD_2 PF13831.1 AMD19356.1 - 0.00011 21.3 2.7 0.00023 20.3 1.9 1.5 1 0 0 1 1 1 1 PHD-finger Pkinase PF00069.20 AMD19357.1 - 3e-53 180.6 3.6 4.3e-52 176.8 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19357.1 - 5.4e-27 94.4 0.2 3.1e-26 92.0 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase TFIIA PF03153.8 AMD19357.1 - 1.8e-06 28.0 25.1 2.7e-06 27.5 17.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Kdo PF06293.9 AMD19357.1 - 0.051 12.6 0.1 0.1 11.6 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CENP-T PF15511.1 AMD19357.1 - 0.1 11.8 16.0 0.16 11.1 11.1 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T DUF1212 PF06738.7 AMD19358.1 - 9.7e-50 168.7 11.3 4.2e-46 156.8 0.6 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 AMD19358.1 - 1.1e-25 90.0 9.1 1.1e-25 90.0 6.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3815) DUF2919 PF11143.3 AMD19358.1 - 0.015 15.1 1.0 0.032 14.0 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2919) BP28CT PF08146.7 AMD19359.1 - 3.1e-39 134.1 4.3 3.1e-39 134.1 3.0 3.1 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.3 AMD19359.1 - 2.8e-20 72.4 0.8 2.8e-20 72.4 0.6 4.0 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.1 AMD19359.1 - 3.7e-06 27.1 0.1 0.063 13.5 0.0 4.8 4 0 0 4 4 4 2 HEAT repeats Katanin_con80 PF13925.1 AMD19359.1 - 0.0015 18.2 3.1 0.0024 17.6 0.0 3.0 3 0 0 3 3 3 1 con80 domain of Katanin HEAT_EZ PF13513.1 AMD19359.1 - 0.0097 16.3 1.4 3.5 8.2 0.1 4.2 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.17 AMD19359.1 - 0.077 13.1 10.3 0.13 12.4 0.0 5.0 6 0 0 6 6 6 0 HEAT repeat UNC-50 PF05216.8 AMD19360.1 - 1e-87 293.2 21.1 1.1e-87 293.0 14.6 1.0 1 0 0 1 1 1 1 UNC-50 family PLDc PF00614.17 AMD19361.1 - 1.6e-15 56.3 0.9 2.7e-07 30.1 0.2 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 AMD19361.1 - 4.9e-12 45.6 0.0 1.4e-07 31.3 0.0 3.4 2 0 0 2 2 2 2 PLD-like domain PX PF00787.19 AMD19361.1 - 1.4e-06 28.0 5.1 0.001 18.8 0.4 3.7 3 0 0 3 3 3 2 PX domain DOPA_dioxygen PF08883.6 AMD19362.1 - 1.9e-23 82.5 0.0 2.3e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family GATA PF00320.22 AMD19363.1 - 6.9e-13 47.7 6.0 1.2e-12 46.9 4.1 1.4 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 AMD19363.1 - 0.058 12.7 0.6 0.11 11.8 0.4 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Auto_anti-p27 PF06677.7 AMD19363.1 - 0.7 9.7 2.5 1.2 8.9 1.7 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Snf7 PF03357.16 AMD19364.1 - 1.7e-16 60.0 18.8 2.4e-16 59.6 13.0 1.1 1 0 0 1 1 1 1 Snf7 FliG_N PF14842.1 AMD19364.1 - 0.2 11.7 6.1 0.96 9.5 0.3 2.4 1 1 1 2 2 2 0 FliG N-terminal domain Baculo_PEP_C PF04513.7 AMD19364.1 - 0.52 10.1 5.9 0.22 11.3 1.1 2.3 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MMPL PF03176.10 AMD19364.1 - 1.3 7.6 4.5 0.29 9.7 0.7 1.6 2 0 0 2 2 2 0 MMPL family Cpn60_TCP1 PF00118.19 AMD19365.1 - 8.7e-150 499.5 3.0 1e-149 499.3 2.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PIR PF00399.14 AMD19366.1 - 6.9e-05 22.0 5.3 6.9e-05 22.0 3.7 3.3 3 0 0 3 3 3 1 Yeast PIR protein repeat FtsH_ext PF06480.10 AMD19366.1 - 0.35 11.0 3.1 1 9.5 2.2 1.9 1 1 0 1 1 1 0 FtsH Extracellular IER PF05760.7 AMD19366.1 - 0.95 9.3 6.2 1.1 9.1 4.3 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) Mito_fiss_reg PF05308.6 AMD19366.1 - 4.1 6.6 8.2 5.1 6.3 5.7 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator FKBP_C PF00254.23 AMD19367.1 - 3.4e-33 113.5 0.0 4.1e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Eaf7 PF07904.8 AMD19368.1 - 2.9e-30 104.0 0.8 6.3e-30 103.0 0.5 1.6 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 zf-PARP PF00645.13 AMD19368.1 - 0.042 14.0 0.2 0.11 12.7 0.1 1.7 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region S4 PF01479.20 AMD19369.1 - 1.7e-12 46.5 0.0 3e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.1 AMD19369.1 - 0.065 12.8 0.0 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 S4 domain CAP_N PF01213.14 AMD19370.1 - 9.1e-91 304.3 0.2 1.2e-90 304.0 0.2 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 AMD19370.1 - 6.3e-59 197.8 2.0 9.4e-59 197.3 1.4 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal RRM_6 PF14259.1 AMD19371.1 - 0.0012 18.7 0.0 0.0026 17.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD19371.1 - 0.065 12.8 0.0 0.35 10.5 0.0 2.3 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SF3b10 PF07189.6 AMD19372.1 - 5.3e-25 87.0 0.2 5.8e-25 86.9 0.1 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Tho2 PF11262.3 AMD19373.1 - 2.2e-53 181.2 8.0 2.2e-53 181.2 5.5 4.0 4 1 0 4 4 4 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 AMD19373.1 - 4.1e-25 87.3 0.1 1.3e-24 85.7 0.1 2.0 1 0 0 1 1 1 1 Transcription- and export-related complex subunit DUF4627 PF15425.1 AMD19373.1 - 0.015 14.8 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4627) C2 PF00168.25 AMD19374.1 - 5e-10 39.0 0.0 1e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain RNA_pol_3_Rpc31 PF11705.3 AMD19375.1 - 2.2e-66 224.1 12.5 2.4e-66 223.9 8.7 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF3295 PF11702.3 AMD19375.1 - 0.46 9.4 3.0 0.49 9.3 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) PGA2 PF07543.7 AMD19376.1 - 7.7e-15 54.9 10.1 2.3e-08 33.9 3.8 2.0 1 1 1 2 2 2 2 Protein trafficking PGA2 ATP-synt_B PF00430.13 AMD19376.1 - 0.0069 16.1 6.1 0.043 13.6 4.2 1.9 1 1 0 1 1 1 1 ATP synthase B/B' CF(0) DUF1542 PF07564.6 AMD19376.1 - 0.069 13.1 1.6 0.069 13.1 1.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF1049 PF06305.6 AMD19376.1 - 1.4 8.4 3.6 2.4 7.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) YqzH PF14164.1 AMD19376.1 - 2.3 8.1 4.8 1.7 8.6 0.9 2.0 1 1 1 2 2 2 0 YqzH-like protein YtxH PF12732.2 AMD19376.1 - 5.6 7.4 7.7 8.6 6.8 1.3 2.3 2 1 0 2 2 2 0 YtxH-like protein CAP_GLY PF01302.20 AMD19377.1 - 7.8e-22 76.7 0.2 1.3e-21 76.0 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 AMD19377.1 - 1.6e-09 37.8 0.0 2.8e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Gemin6 PF06372.7 AMD19377.1 - 0.03 13.6 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Gemin6 protein LSM PF01423.17 AMD19378.1 - 8e-18 63.7 0.4 1e-17 63.4 0.3 1.1 1 0 0 1 1 1 1 LSM domain UPRTase PF14681.1 AMD19379.1 - 2.1e-76 255.7 0.0 2.5e-76 255.5 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase CoA_binding_2 PF13380.1 AMD19379.1 - 0.011 15.8 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain Pribosyltran PF00156.22 AMD19379.1 - 0.017 14.8 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 AMD19379.1 - 0.076 12.7 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) Actin PF00022.14 AMD19380.1 - 5.7e-124 413.5 0.0 6.5e-124 413.3 0.0 1.0 1 0 0 1 1 1 1 Actin DUF2009 PF09418.5 AMD19381.1 - 8.4e-219 727.0 0.4 1e-218 726.7 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.19 AMD19381.1 - 2.6e-05 24.0 5.6 5.1e-05 23.0 3.9 1.5 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.16 AMD19381.1 - 0.02 14.7 4.0 0.045 13.6 2.8 1.5 1 0 0 1 1 1 0 IBR domain PH_9 PF15410.1 AMD19382.1 - 0.11 12.6 0.0 0.44 10.7 0.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Pga1 PF10333.4 AMD19384.1 - 1.3e-51 174.7 0.0 1.6e-51 174.5 0.0 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator fn3 PF00041.16 AMD19384.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Fibronectin type III domain Endosulfine PF04667.12 AMD19385.1 - 7e-33 112.4 0.2 9.4e-33 112.0 0.2 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region INSIG PF07281.7 AMD19386.1 - 1.9e-12 46.9 2.2 2.7e-12 46.4 1.5 1.3 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) Thia_YuaJ PF09515.5 AMD19386.1 - 0.1 12.3 7.2 3.4 7.4 0.0 2.4 1 1 0 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) WLM PF08325.5 AMD19387.1 - 8.3e-48 162.7 0.0 1.4e-47 161.9 0.0 1.4 1 1 0 1 1 1 1 WLM domain zf-AN1 PF01428.11 AMD19389.1 - 5.8e-12 45.2 7.9 8.7e-12 44.7 5.5 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Pkinase PF00069.20 AMD19390.1 - 3.9e-31 108.1 0.0 3.9e-31 108.1 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19390.1 - 6.4e-12 45.0 0.0 1.4e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Mito_fiss_reg PF05308.6 AMD19390.1 - 0.012 14.9 8.5 0.012 14.9 5.9 2.1 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF3828 PF12883.2 AMD19391.1 - 0.13 12.1 0.1 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3828) UIM PF02809.15 AMD19391.1 - 4.8 7.0 9.2 0.13 11.8 1.2 2.4 2 0 0 2 2 2 0 Ubiquitin interaction motif Prefoldin_2 PF01920.15 AMD19392.1 - 9.9e-19 67.0 15.0 1.2e-18 66.8 10.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit Osmo_CC PF08946.5 AMD19392.1 - 0.037 14.0 7.0 0.037 14.0 4.9 2.5 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Nup54 PF13874.1 AMD19392.1 - 0.053 13.1 1.5 0.053 13.1 1.1 1.6 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 MAP65_ASE1 PF03999.7 AMD19392.1 - 0.065 11.8 7.8 0.074 11.6 5.4 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DNA_topoisoIV PF00521.15 AMD19392.1 - 0.65 8.7 6.8 0.75 8.5 4.7 1.1 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Fib_alpha PF08702.5 AMD19392.1 - 0.88 9.6 6.2 1 9.5 3.6 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Prefoldin_3 PF13758.1 AMD19392.1 - 1 9.2 7.9 1.5 8.6 5.5 1.4 1 1 0 1 1 1 0 Prefoldin subunit DUF4559 PF15112.1 AMD19392.1 - 1.1 8.3 8.5 1.5 7.9 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF948 PF06103.6 AMD19392.1 - 2.3 8.1 5.4 1.8 8.4 0.3 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.7 AMD19392.1 - 2.4 8.4 5.8 0.83 9.9 0.7 2.2 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.9 AMD19392.1 - 7.7 6.0 10.9 14 5.2 7.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF724) XhlA PF10779.4 AMD19392.1 - 9.8 6.1 12.1 0.33 10.9 2.1 2.1 2 0 0 2 2 2 0 Haemolysin XhlA Inhibitor_I9 PF05922.11 AMD19393.1 - 0.1 13.2 0.0 0.17 12.4 0.0 1.6 1 1 0 1 1 1 0 Peptidase inhibitor I9 SLAM PF06214.6 AMD19393.1 - 0.1 12.5 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Signaling lymphocytic activation molecule (SLAM) protein Far-17a_AIG1 PF04750.9 AMD19394.1 - 2.2e-18 66.1 7.0 2.7e-18 65.8 4.9 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Pkinase PF00069.20 AMD19395.1 - 1.8e-59 201.0 0.4 9e-40 136.4 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19395.1 - 4.5e-26 91.4 3.6 3.8e-20 72.0 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 AMD19395.1 - 0.0018 17.2 0.0 0.0069 15.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 AMD19395.1 - 0.004 16.2 0.0 0.013 14.6 0.0 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD19395.1 - 0.012 15.3 0.3 0.82 9.3 0.1 3.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 AMD19395.1 - 0.028 13.2 0.0 0.044 12.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_C PF00433.19 AMD19395.1 - 0.046 14.2 1.4 0.11 13.0 0.0 2.5 3 0 0 3 3 3 0 Protein kinase C terminal domain Pox_ser-thr_kin PF05445.6 AMD19395.1 - 0.076 11.7 0.1 0.12 11.1 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF1982 PF09326.6 AMD19395.1 - 0.097 12.8 0.2 0.75 10.0 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1982) Ribosomal_L44 PF00935.14 AMD19396.1 - 1.9e-33 114.2 11.3 2.9e-33 113.6 7.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Chs3p PF12271.3 AMD19397.1 - 1.1e-86 290.4 19.6 1.8e-86 289.7 13.6 1.3 1 1 0 1 1 1 1 Chitin synthase III catalytic subunit PyrI_C PF02748.10 AMD19398.1 - 0.038 13.4 0.1 0.038 13.4 0.1 1.7 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GTP_EFTU PF00009.22 AMD19399.1 - 1.6e-53 180.9 0.0 2.7e-53 180.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 AMD19399.1 - 5.3e-13 48.6 0.0 1.8e-12 46.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 AMD19399.1 - 1.5e-10 41.0 0.0 4.2e-10 39.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 AMD19399.1 - 9.4e-10 38.2 0.0 3.4e-09 36.4 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_IV PF03764.13 AMD19399.1 - 6.6e-07 28.9 0.0 3.4e-06 26.5 0.0 2.2 1 1 0 1 1 1 1 Elongation factor G, domain IV Ribosomal_L6e PF01159.14 AMD19399.1 - 0.64 10.2 4.3 2.2 8.5 0.0 3.4 1 1 1 3 3 3 0 Ribosomal protein L6e Tmemb_cc2 PF10267.4 AMD19400.1 - 0.015 13.9 2.4 0.025 13.1 1.7 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein CDC45 PF02724.9 AMD19400.1 - 0.089 10.8 3.9 0.14 10.2 2.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Pox_A12 PF04651.8 AMD19400.1 - 2.8 8.0 10.3 0.079 13.0 1.9 1.9 2 0 0 2 2 2 0 Poxvirus A12 protein Nup54 PF13874.1 AMD19401.1 - 0.55 9.8 3.2 0.26 10.9 0.3 1.8 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DNA_RNApol_7kD PF03604.8 AMD19402.1 - 8.3e-17 60.3 1.9 1.1e-16 60.0 1.3 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.2 AMD19402.1 - 0.00084 19.1 0.5 0.0011 18.7 0.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.14 AMD19402.1 - 0.0014 18.3 0.2 0.0014 18.3 0.1 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family TFIIS_C PF01096.13 AMD19402.1 - 0.0036 16.9 1.0 1.6 8.4 0.1 2.3 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) Prok-RING_1 PF14446.1 AMD19402.1 - 0.0099 15.5 0.5 0.013 15.2 0.4 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 NCD3G PF07562.9 AMD19402.1 - 0.021 14.5 0.2 0.027 14.2 0.1 1.2 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR DUF951 PF06107.6 AMD19402.1 - 0.022 14.2 1.9 0.42 10.1 0.3 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) DUF2318 PF10080.4 AMD19402.1 - 0.029 14.1 0.1 0.032 14.0 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) DUF2296 PF10058.4 AMD19402.1 - 0.031 14.0 0.4 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) C1_1 PF00130.17 AMD19402.1 - 0.032 13.9 0.5 0.046 13.4 0.3 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYDLN_acid PF09538.5 AMD19402.1 - 0.036 14.6 0.2 0.042 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf-ribbon_3 PF13248.1 AMD19402.1 - 0.047 12.9 0.3 0.48 9.7 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain A2L_zn_ribbon PF08792.5 AMD19402.1 - 0.072 12.5 1.0 1.1 8.8 0.0 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain OrfB_Zn_ribbon PF07282.6 AMD19402.1 - 0.12 12.0 0.8 0.17 11.5 0.5 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF2197 PF09963.4 AMD19402.1 - 0.13 12.2 2.0 6.7 6.7 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-AN1 PF01428.11 AMD19402.1 - 0.14 12.0 1.0 0.26 11.1 0.7 1.4 1 1 0 1 1 1 0 AN1-like Zinc finger Ogr_Delta PF04606.7 AMD19402.1 - 0.14 11.8 1.0 8.8 6.0 0.1 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger DUF4428 PF14471.1 AMD19402.1 - 0.19 11.4 1.3 1.4 8.7 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) TF_Zn_Ribbon PF08271.7 AMD19402.1 - 0.21 10.9 2.8 5.3 6.4 0.3 2.1 1 1 2 3 3 3 0 TFIIB zinc-binding Ribosomal_L40e PF01020.12 AMD19402.1 - 0.34 10.5 2.2 0.44 10.1 1.5 1.2 1 0 0 1 1 1 0 Ribosomal L40e family Zn-ribbon_8 PF09723.5 AMD19402.1 - 0.34 10.8 2.9 1.1 9.3 2.0 1.8 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_5 PF13719.1 AMD19402.1 - 0.38 10.3 4.3 2.1 7.9 3.0 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 AMD19402.1 - 0.42 10.4 3.4 2.5 7.9 0.2 1.9 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.1 AMD19402.1 - 0.5 10.0 4.6 3 7.6 3.2 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Zn_ribbon_recom PF13408.1 AMD19402.1 - 0.71 10.1 4.0 8 6.8 0.7 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Ribosomal_L44 PF00935.14 AMD19402.1 - 1.4 8.9 4.1 13 5.8 0.3 2.1 1 1 1 2 2 2 0 Ribosomal protein L44 Aft1_OSA PF11785.3 AMD19403.1 - 9.9e-08 32.4 0.7 2.9e-07 30.9 0.1 2.1 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.16 AMD19403.1 - 2.2e-07 30.7 3.2 4.9e-07 29.5 2.2 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 AMD19403.1 - 0.0004 20.1 7.1 0.0015 18.3 4.9 1.9 1 1 0 1 1 1 1 Basic region leucine zipper Aft1_HRA PF11786.3 AMD19403.1 - 0.002 18.3 1.1 0.002 18.3 0.8 3.0 2 1 1 3 3 3 1 Aft1 HRA domain PP1_bind PF15276.1 AMD19403.1 - 0.043 13.8 0.1 0.22 11.5 0.1 2.4 1 0 0 1 1 1 0 Protein phosphatase 1 binding DUF2570 PF10828.3 AMD19403.1 - 0.17 11.4 1.2 0.47 10.0 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) FAA_hydrolase PF01557.13 AMD19404.1 - 6.1e-47 159.8 0.0 8e-47 159.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family dCMP_cyt_deam_1 PF00383.17 AMD19405.1 - 2.9e-25 87.8 2.7 4.3e-25 87.3 1.8 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Cytidylate_kin2 PF13189.1 AMD19405.1 - 0.1 12.4 0.0 0.88 9.4 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase-like family PS_Dcarbxylase PF02666.10 AMD19406.1 - 3.3e-73 245.2 0.0 4.6e-73 244.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Apc1 PF12859.2 AMD19407.1 - 4.9e-12 45.9 0.3 1.2e-10 41.5 0.2 3.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 RRM_1 PF00076.17 AMD19409.1 - 6.3e-28 96.2 0.1 3.2e-17 61.9 0.0 3.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD19409.1 - 4.1e-22 77.9 0.1 1e-11 44.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD19409.1 - 5.2e-12 45.4 0.1 1.6e-05 24.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 AMD19409.1 - 0.002 17.8 0.0 0.0082 15.8 0.0 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Gag_p30 PF02093.11 AMD19409.1 - 0.0057 15.8 0.1 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Gag P30 core shell protein Ribosomal_L22 PF00237.14 AMD19411.1 - 2.6e-19 69.1 0.0 6.3e-19 67.8 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e SHR3_chaperone PF08229.6 AMD19412.1 - 5.6e-77 257.1 0.3 6.4e-77 256.9 0.2 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 Ribosomal_S3_C PF00189.15 AMD19413.1 - 3e-16 59.4 0.1 5.4e-16 58.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 AMD19413.1 - 9.6e-12 44.3 0.0 3.3e-11 42.5 0.0 1.9 2 0 0 2 2 2 1 KH domain Ras PF00071.17 AMD19414.1 - 9.9e-47 158.3 0.0 1.2e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD19414.1 - 4.1e-16 59.5 0.0 3.6e-15 56.4 0.0 2.3 2 1 0 2 2 2 1 Miro-like protein Arf PF00025.16 AMD19414.1 - 1.7e-07 30.6 0.0 2.9e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD19414.1 - 8e-05 22.1 0.0 0.0004 19.8 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD19414.1 - 0.027 14.4 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF1639 PF07797.9 AMD19414.1 - 1.7 8.0 3.7 6.2 6.2 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) adh_short PF00106.20 AMD19415.1 - 2.4e-08 34.0 0.0 8.2e-08 32.3 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AMD19415.1 - 5.7e-07 29.3 0.0 8.8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 AMD19415.1 - 0.027 14.2 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase WD40 PF00400.27 AMD19416.1 - 1.6e-05 24.6 0.6 0.69 9.8 0.0 4.2 5 0 0 5 5 5 2 WD domain, G-beta repeat CNH PF00780.17 AMD19416.1 - 0.016 14.6 0.4 0.27 10.6 0.0 2.4 2 1 0 2 2 2 0 CNH domain PQQ_3 PF13570.1 AMD19416.1 - 0.14 12.4 1.7 6.5 7.1 0.0 3.7 4 1 0 4 4 4 0 PQQ-like domain bZIP_1 PF00170.16 AMD19416.1 - 0.51 10.3 2.7 1 9.3 1.9 1.5 1 0 0 1 1 1 0 bZIP transcription factor RRM_1 PF00076.17 AMD19417.1 - 1.5e-07 30.9 0.0 2.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD19417.1 - 6.9e-06 25.9 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 AMD19418.1 - 2.2e-59 200.7 0.0 3.4e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19418.1 - 4.4e-21 75.1 0.0 7.4e-21 74.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 AMD19418.1 - 0.0014 17.9 0.1 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 AMD19418.1 - 0.13 11.2 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 AMD19418.1 - 0.15 11.1 0.0 0.27 10.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L11_N PF03946.9 AMD19419.1 - 1.5e-27 94.8 0.3 2.5e-27 94.1 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 AMD19419.1 - 1.1e-23 83.1 0.3 1.8e-23 82.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain UCH PF00443.24 AMD19420.1 - 2.1e-58 197.5 1.9 4.8e-58 196.3 1.3 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD19420.1 - 5.6e-17 62.1 0.4 5.6e-17 62.1 0.3 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase JAB PF01398.16 AMD19421.1 - 1.6e-25 89.0 0.5 4.3e-25 87.6 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 AMD19421.1 - 5.8e-08 32.2 0.0 1.6e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 AMD19421.1 - 0.021 14.3 0.0 0.066 12.7 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0172) TMEM51 PF15345.1 AMD19421.1 - 0.041 13.5 3.3 0.095 12.3 2.3 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 PRP1_N PF06424.7 AMD19421.1 - 0.15 12.3 4.3 0.31 11.3 3.0 1.4 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal FadA PF09403.5 AMD19421.1 - 0.23 11.4 3.7 0.13 12.2 0.4 2.2 2 0 0 2 2 2 0 Adhesion protein FadA PQQ_2 PF13360.1 AMD19422.1 - 0.1 12.0 0.0 0.21 10.9 0.0 1.6 2 0 0 2 2 2 0 PQQ-like domain Tim17 PF02466.14 AMD19423.1 - 2e-45 153.9 5.5 2.4e-45 153.6 3.8 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_Omp PF13488.1 AMD19423.1 - 0.088 12.4 0.2 0.088 12.4 0.1 2.5 3 0 0 3 3 3 0 Glycine zipper Arm PF00514.18 AMD19425.1 - 8e-86 279.2 16.6 2.4e-14 52.5 0.1 8.7 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 AMD19425.1 - 5.8e-22 77.7 0.1 1.8e-06 28.1 0.0 5.6 1 1 6 7 7 7 7 HEAT repeats IBB PF01749.15 AMD19425.1 - 2.2e-21 75.7 12.4 4.6e-21 74.7 8.0 2.1 2 1 0 2 2 1 1 Importin beta binding domain HEAT_EZ PF13513.1 AMD19425.1 - 1.7e-19 69.6 2.7 2.4e-05 24.6 0.0 6.2 4 2 3 7 7 7 4 HEAT-like repeat HEAT PF02985.17 AMD19425.1 - 2e-13 49.2 1.0 0.0084 16.1 0.0 6.6 7 0 0 7 7 7 2 HEAT repeat Arm_2 PF04826.8 AMD19425.1 - 3.2e-07 29.7 2.1 0.91 8.5 0.1 4.8 2 1 2 5 5 5 3 Armadillo-like Adaptin_N PF01602.15 AMD19425.1 - 1.5e-05 23.5 0.8 0.0014 17.0 0.1 2.6 1 1 2 3 3 3 2 Adaptin N terminal region RICTOR_V PF14668.1 AMD19425.1 - 7.7e-05 22.5 4.1 3.4 7.6 0.1 5.4 2 2 5 7 7 7 2 Rapamycin-insensitive companion of mTOR, domain 5 Proteasom_PSMB PF10508.4 AMD19425.1 - 0.00023 19.6 2.3 0.0022 16.3 0.0 2.6 3 0 0 3 3 3 1 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.3 AMD19425.1 - 0.00025 20.9 0.1 1.1 9.1 0.0 4.2 2 1 3 5 5 5 2 V-ATPase subunit H FAST_1 PF06743.10 AMD19425.1 - 0.027 14.1 1.5 0.94 9.2 0.0 3.3 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 FARP PF01581.11 AMD19426.1 - 0.088 13.1 3.6 63 4.5 0.0 5.4 6 0 0 6 6 6 0 FMRFamide related peptide family GATase_4 PF13230.1 AMD19427.1 - 1.5e-18 66.4 0.0 1.1e-17 63.6 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.16 AMD19427.1 - 4.1e-10 38.8 0.1 2.4e-08 33.1 0.0 2.1 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 AMD19427.1 - 9.1e-10 38.6 0.0 1.7e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 AMD19427.1 - 0.052 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Glutamine amidotransferase domain Tyr_Deacylase PF02580.11 AMD19428.1 - 2.9e-47 160.2 0.1 3.3e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Chitin_synth_1 PF01644.12 AMD19429.1 - 1.8e-73 245.7 0.2 2.7e-73 245.1 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 AMD19429.1 - 1.2e-24 85.7 0.0 4e-24 84.1 0.0 1.9 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 AMD19429.1 - 1.4e-18 66.6 9.3 3.3e-16 58.8 1.3 2.4 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 AMD19429.1 - 1.1e-09 38.3 4.2 6.6e-09 35.7 2.9 2.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 AMD19429.1 - 1.4e-06 28.3 0.0 9.9e-06 25.5 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 TPR_11 PF13414.1 AMD19430.1 - 0.041 13.5 0.2 0.55 9.9 0.0 2.5 3 0 0 3 3 3 0 TPR repeat SUR7 PF06687.7 AMD19432.1 - 4.1e-34 118.0 2.3 4.1e-34 118.0 1.6 1.6 2 0 0 2 2 2 1 SUR7/PalI family Claudin_2 PF13903.1 AMD19432.1 - 0.0077 15.9 2.4 0.0077 15.9 1.6 3.4 2 1 0 3 3 3 1 PMP-22/EMP/MP20/Claudin tight junction Fig1 PF12351.3 AMD19432.1 - 0.033 14.0 1.0 0.074 12.9 0.7 1.6 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 VIT1 PF01988.14 AMD19432.1 - 0.15 11.5 2.9 0.17 11.3 0.5 2.0 2 0 0 2 2 2 0 VIT family Rap1-DNA-bind PF09197.5 AMD19433.1 - 3.9e-46 155.9 3.4 2.3e-41 140.5 0.9 2.8 2 0 0 2 2 2 2 Rap1, DNA-binding Rap1_C PF11626.3 AMD19433.1 - 1.5e-23 82.4 0.0 3.1e-22 78.2 0.0 3.1 4 0 0 4 4 4 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.26 AMD19433.1 - 1.2e-10 41.2 1.2 3.4e-08 33.4 0.0 3.9 3 1 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 AMD19433.1 - 1.4e-07 31.1 1.5 9.8e-05 22.0 0.0 2.9 3 0 0 3 3 3 2 Rap1 Myb domain BRCT PF00533.21 AMD19433.1 - 2.1e-05 24.5 0.2 6.6e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Myb_DNA-bind_6 PF13921.1 AMD19433.1 - 0.00043 20.3 0.8 0.16 12.0 0.0 3.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Hpt PF01627.18 AMD19434.1 - 5e-11 42.4 0.0 5.8e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Hpt domain MgsA_C PF12002.3 AMD19435.1 - 2.1e-54 183.6 0.3 7.8e-54 181.8 0.1 1.9 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA PF00004.24 AMD19435.1 - 6e-17 62.0 0.1 1.1e-16 61.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD19435.1 - 2.7e-15 56.0 0.1 1.5e-14 53.6 0.0 2.2 2 1 1 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 AMD19435.1 - 1.1e-08 35.3 0.1 2.2e-06 27.8 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 AMD19435.1 - 9.6e-08 31.9 0.0 2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 AMD19435.1 - 1e-07 31.7 0.0 2.5e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 AMD19435.1 - 1.6e-07 31.5 1.9 1.7e-06 28.1 0.3 2.9 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 AMD19435.1 - 5.1e-05 22.5 0.1 0.028 13.5 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 AMD19435.1 - 0.00015 21.3 0.0 0.0023 17.4 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain DNA_pol3_delta2 PF13177.1 AMD19435.1 - 0.0002 21.0 0.1 0.011 15.4 0.0 2.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_3 PF07726.6 AMD19435.1 - 0.00027 20.5 0.1 0.00052 19.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 AMD19435.1 - 0.00092 19.1 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 AMD19435.1 - 0.0017 17.7 0.0 0.0041 16.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.8 AMD19435.1 - 0.002 17.0 0.0 0.0036 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ResIII PF04851.10 AMD19435.1 - 0.0027 17.5 0.5 0.057 13.2 0.2 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_18 PF13238.1 AMD19435.1 - 0.0028 17.9 0.1 0.01 16.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain Sigma54_activ_2 PF14532.1 AMD19435.1 - 0.0028 17.7 0.3 0.028 14.4 0.0 2.4 1 1 1 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.22 AMD19435.1 - 0.0028 17.9 0.0 0.01 16.1 0.0 2.0 2 0 0 2 2 1 1 ABC transporter AAA_30 PF13604.1 AMD19435.1 - 0.0032 17.0 0.0 0.0099 15.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 AMD19435.1 - 0.004 17.3 0.0 0.01 15.9 0.0 1.8 1 0 0 1 1 1 1 RNA helicase Bac_DnaA PF00308.13 AMD19435.1 - 0.0046 16.6 0.0 0.0081 15.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial dnaA protein TIP49 PF06068.8 AMD19435.1 - 0.0052 15.5 0.0 0.019 13.6 0.0 1.8 1 1 0 2 2 2 1 TIP49 C-terminus Arch_ATPase PF01637.13 AMD19435.1 - 0.0086 15.7 0.1 0.021 14.5 0.0 1.7 1 0 0 1 1 1 1 Archaeal ATPase AAA_24 PF13479.1 AMD19435.1 - 0.0096 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD19435.1 - 0.011 16.5 0.0 0.032 15.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sgf11 PF08209.6 AMD19435.1 - 0.012 14.9 0.1 0.021 14.1 0.1 1.4 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) NACHT PF05729.7 AMD19435.1 - 0.018 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.13 AMD19435.1 - 0.025 14.1 0.0 0.053 13.0 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.18 AMD19435.1 - 0.026 14.4 0.0 0.06 13.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.1 AMD19435.1 - 0.048 13.6 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.11 AMD19435.1 - 0.058 12.1 0.0 0.12 11.1 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase DHDPS PF00701.17 AMD19435.1 - 0.07 11.7 0.1 0.13 10.8 0.1 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Hydrolase_6 PF13344.1 AMD19436.1 - 2.9e-28 97.6 0.0 7.8e-28 96.3 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AMD19436.1 - 7.1e-11 41.6 0.0 1.3e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 AMD19436.1 - 2.5e-10 41.1 0.0 4.4e-10 40.3 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 AMD19436.1 - 1.2e-07 32.1 0.1 0.0012 19.0 0.2 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Glyco_transf_22 PF03901.12 AMD19437.1 - 3.9e-94 316.0 25.0 5.3e-94 315.5 17.3 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Adenylsucc_synt PF00709.16 AMD19438.1 - 1.2e-163 544.6 0.0 1.4e-163 544.4 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase MCD PF05292.6 AMD19438.1 - 0.11 11.1 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase (MCD) POP1 PF06978.6 AMD19439.1 - 3.9e-64 215.7 18.6 2.2e-63 213.3 12.9 2.1 1 1 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 AMD19439.1 - 1.3e-30 105.0 1.2 3.3e-30 103.7 0.8 1.8 1 0 0 1 1 1 1 POPLD (NUC188) domain DUF1389 PF07146.6 AMD19439.1 - 0.14 11.2 1.6 0.61 9.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1389) GCV_T_C PF08669.6 AMD19439.1 - 0.15 12.0 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain Ssu72 PF04722.8 AMD19441.1 - 3.3e-89 297.4 0.1 3.7e-89 297.2 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein Peptidase_C54 PF03416.14 AMD19442.1 - 9.6e-87 290.6 0.0 1.4e-86 290.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 G-patch PF01585.18 AMD19443.1 - 4.9e-11 42.2 0.6 1.1e-10 41.0 0.4 1.7 1 0 0 1 1 1 1 G-patch domain R3H PF01424.17 AMD19443.1 - 0.00029 20.4 0.0 0.0009 18.8 0.0 1.9 1 0 0 1 1 1 1 R3H domain Myc_N PF01056.13 AMD19443.1 - 0.16 11.0 7.4 0.42 9.7 5.1 1.7 1 0 0 1 1 1 0 Myc amino-terminal region Vpu PF00558.14 AMD19443.1 - 0.18 11.4 0.0 0.18 11.4 0.0 2.9 3 0 0 3 3 3 0 Vpu protein Cytomega_UL84 PF06284.6 AMD19443.1 - 1.6 7.0 5.5 3.1 6.0 3.8 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein SID PF11778.3 AMD19444.1 - 3.6e-55 185.6 6.3 3.6e-55 185.6 4.4 2.8 2 0 0 2 2 2 1 Septation initiation IncA PF04156.9 AMD19444.1 - 6.8e-05 22.5 115.5 0.0045 16.6 15.9 5.4 2 2 2 4 4 4 3 IncA protein AAA_13 PF13166.1 AMD19444.1 - 0.00057 18.4 99.6 0.14 10.6 25.0 4.7 1 1 5 6 6 6 5 AAA domain DUF3584 PF12128.3 AMD19444.1 - 0.0013 16.2 97.7 0.037 11.3 21.4 3.5 3 1 1 4 4 4 3 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.7 AMD19444.1 - 0.3 10.2 61.0 0.01 15.0 10.2 5.6 1 1 4 6 6 6 0 Reovirus sigma C capsid protein Spc7 PF08317.6 AMD19444.1 - 1 7.9 114.1 0.19 10.3 14.7 5.4 2 2 3 5 5 5 0 Spc7 kinetochore protein HTH_Tnp_Tc3_1 PF11427.3 AMD19444.1 - 1.3 8.7 6.6 2.3 7.9 0.6 3.9 3 1 1 4 4 4 0 Tc3 transposase NAD_kinase PF01513.16 AMD19444.1 - 2 7.1 5.1 1.2 7.8 1.4 2.2 1 1 0 1 1 1 0 ATP-NAD kinase MscS_porin PF12795.2 AMD19444.1 - 2.6 7.3 109.6 0.3 10.3 21.5 5.8 2 2 4 6 6 5 0 Mechanosensitive ion channel porin domain ATG16 PF08614.6 AMD19444.1 - 2.8 7.7 115.8 0.81 9.4 9.5 7.2 3 2 3 7 7 7 0 Autophagy protein 16 (ATG16) IFT57 PF10498.4 AMD19444.1 - 5.1 5.7 91.6 3 6.4 14.8 4.4 2 1 2 4 4 4 0 Intra-flagellar transport protein 57 Tropomyosin PF00261.15 AMD19444.1 - 8.4 5.4 107.6 0.097 11.7 31.6 4.8 1 1 1 3 3 3 0 Tropomyosin DnaJ PF00226.26 AMD19445.1 - 6.3e-25 86.7 0.7 6.3e-25 86.7 0.5 2.5 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.3 AMD19445.1 - 1.7e-06 28.0 12.8 1.5e-05 24.9 4.2 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 AMD19445.1 - 3.1e-05 24.0 8.0 0.027 14.5 2.8 2.8 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 AMD19445.1 - 0.00045 20.4 7.3 0.058 13.7 0.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.2 AMD19445.1 - 0.0011 19.0 9.1 0.0072 16.4 2.4 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 AMD19445.1 - 0.018 15.3 3.0 1.3 9.5 0.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AMD19445.1 - 0.086 12.7 0.5 0.086 12.7 0.3 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger GST_C PF00043.20 AMD19446.1 - 9.9e-19 67.1 0.0 1.6e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 AMD19446.1 - 2.2e-15 56.5 0.0 3.9e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 AMD19446.1 - 6.2e-10 38.9 0.0 1.5e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 AMD19446.1 - 4.4e-09 36.4 0.0 8.1e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 AMD19446.1 - 0.0084 15.9 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4175 PF13779.1 AMD19446.1 - 1.3 6.5 6.8 1.9 6.0 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Elongin_A PF06881.6 AMD19448.1 - 2.5e-20 72.8 12.0 1.6e-19 70.2 0.7 2.3 1 1 1 2 2 2 2 RNA polymerase II transcription factor SIII (Elongin) subunit A Sds3 PF08598.6 AMD19448.1 - 1.3 8.5 10.6 1.9 7.9 7.3 1.4 1 1 0 1 1 1 0 Sds3-like EXOSC1 PF10447.4 AMD19449.1 - 1.3e-33 114.7 0.3 2.5e-33 113.8 0.2 1.5 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 Globin PF00042.17 AMD19451.1 - 1.9e-05 24.9 0.0 3.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Globin Med16 PF11635.3 AMD19452.1 - 4.8e-180 600.1 4.7 5.7e-180 599.9 3.3 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 Peptidase_S8 PF00082.17 AMD19453.1 - 2.6e-52 177.7 2.8 4.3e-52 177.0 1.9 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 AMD19453.1 - 8.4e-26 89.5 0.9 1.8e-25 88.5 0.6 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain Gram_pos_anchor PF00746.16 AMD19453.1 - 0.055 13.2 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 Gram positive anchor DUF1180 PF06679.7 AMD19453.1 - 0.093 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Peptidase_C1_2 PF03051.10 AMD19454.1 - 1.4e-157 524.7 1.2 1.6e-157 524.5 0.8 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 AMD19454.1 - 7.5e-08 32.5 0.1 0.0041 17.0 0.1 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Fe_hyd_lg_C PF02906.9 AMD19455.1 - 1.6e-69 234.3 0.0 2.2e-69 233.8 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain G6PD_C PF02781.11 AMD19456.1 - 4.7e-128 426.1 0.0 6e-128 425.8 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 AMD19456.1 - 1.2e-63 214.6 0.0 2.5e-63 213.6 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain RhoGAP PF00620.22 AMD19457.1 - 8.2e-35 119.6 0.5 4e-34 117.4 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.17 AMD19457.1 - 5.4e-24 84.0 59.2 5.1e-09 36.0 4.6 4.5 4 0 0 4 4 4 4 LIM domain Tape_meas_lam_C PF09718.5 AMD19457.1 - 0.087 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) ATG2_CAD PF13329.1 AMD19458.1 - 3.9e-32 111.0 0.7 3.9e-32 111.0 0.5 2.9 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.6 AMD19458.1 - 2e-28 98.4 0.2 5.8e-28 96.9 0.1 1.9 2 0 0 2 2 2 1 ATG C terminal domain Asp PF00026.18 AMD19459.1 - 3.5e-68 230.1 0.6 4.2e-68 229.9 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD19459.1 - 2.9e-07 30.5 0.1 4.4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 AMD19459.1 - 0.0027 18.1 0.3 4.9 7.7 0.2 3.1 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.1 AMD19459.1 - 0.052 13.3 0.0 8.3 6.3 0.0 2.4 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Aldo_ket_red PF00248.16 AMD19460.1 - 7.2e-49 166.1 0.0 8.6e-49 165.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AA_permease_2 PF13520.1 AMD19461.1 - 3.4e-74 249.9 48.9 4.2e-74 249.6 33.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AMD19461.1 - 5.4e-19 67.8 45.1 2.4e-18 65.7 31.3 1.7 1 1 0 1 1 1 1 Amino acid permease SUI1 PF01253.17 AMD19462.1 - 7.9e-29 99.3 0.4 9.5e-29 99.0 0.3 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.3 AMD19462.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Cas_Csa5 PF09702.5 AMD19462.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) MAT_Alpha1 PF04769.7 AMD19463.1 - 6.6e-13 48.4 4.6 7.3e-09 35.2 0.2 2.7 1 1 2 3 3 3 3 Mating-type protein MAT alpha 1 Homeobox_KN PF05920.6 AMD19464.1 - 4.4e-07 29.5 0.4 4.4e-07 29.5 0.3 2.2 3 0 0 3 3 3 1 Homeobox KN domain Homeobox PF00046.24 AMD19464.1 - 8.6e-07 28.4 1.1 3.5e-06 26.5 0.2 2.3 2 0 0 2 2 2 1 Homeobox domain Homez PF11569.3 AMD19464.1 - 2.1e-05 23.4 0.1 4.5e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez HTH_28 PF13518.1 AMD19464.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain EST1_DNA_bind PF10373.4 AMD19464.1 - 0.033 13.3 0.1 0.038 13.1 0.1 1.2 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain HA PF03457.9 AMD19464.1 - 0.043 13.9 0.0 0.072 13.1 0.0 1.5 1 1 0 1 1 1 0 Helicase associated domain Muted PF14942.1 AMD19464.1 - 0.13 12.1 1.8 0.33 10.8 1.2 1.7 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Sec10 PF07393.6 AMD19466.1 - 9.8e-25 86.8 0.2 1.2e-24 86.6 0.1 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 Peptidase_C2 PF00648.16 AMD19466.1 - 0.096 11.6 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Calpain family cysteine protease PALP PF00291.20 AMD19467.1 - 4.8e-58 196.8 0.0 5.4e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GIDA PF01134.17 AMD19467.1 - 0.0035 16.2 0.0 0.012 14.5 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 AMD19467.1 - 0.071 11.9 0.1 0.37 9.5 0.1 2.0 2 1 1 3 3 3 0 FAD binding domain MRC1 PF09444.5 AMD19469.1 - 1.5e-41 142.0 12.1 1.5e-41 142.0 8.4 5.4 5 1 0 6 6 6 1 MRC1-like domain KH_1 PF00013.24 AMD19470.1 - 0.028 14.0 0.0 0.084 12.5 0.0 1.8 1 0 0 1 1 1 0 KH domain EMP24_GP25L PF01105.19 AMD19470.1 - 0.09 12.4 0.3 0.14 11.8 0.2 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD KH_3 PF13014.1 AMD19470.1 - 0.094 12.3 0.0 0.28 10.8 0.0 1.8 2 0 0 2 2 2 0 KH domain Mod_r PF07200.8 AMD19471.1 - 0.0074 16.2 7.8 0.009 15.9 5.4 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein AAA_27 PF13514.1 AMD19471.1 - 0.014 13.1 2.4 0.015 13.0 1.6 1.0 1 0 0 1 1 1 0 AAA domain FNIP_N PF14636.1 AMD19471.1 - 0.3 11.5 4.4 0.4 11.1 3.1 1.1 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus RloB PF13707.1 AMD19471.1 - 0.53 9.9 5.5 0.63 9.6 3.8 1.0 1 0 0 1 1 1 0 RloB-like protein DUF4591 PF15261.1 AMD19471.1 - 1.7 8.9 11.1 6.7 6.9 6.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4591) Consortin_C PF15281.1 AMD19471.1 - 4.6 6.7 8.0 0.35 10.3 0.4 2.0 1 1 1 2 2 2 0 Consortin C-terminus DUF334 PF03904.8 AMD19471.1 - 5.3 6.2 7.1 6.7 5.9 4.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF334) V_ATPase_I PF01496.14 AMD19471.1 - 5.8 4.6 5.8 6.7 4.4 4.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM60A PF15396.1 AMD19471.1 - 9.5 5.9 8.0 10 5.8 5.5 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF543 PF04418.7 AMD19472.1 - 6.2e-30 102.9 0.4 6.9e-30 102.8 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) NADH_dh_m_C1 PF15088.1 AMD19472.1 - 1.7 8.2 3.8 11 5.6 0.1 2.2 1 1 1 2 2 2 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Peptidase_M3 PF01432.15 AMD19473.1 - 3.7e-133 444.9 0.6 3.7e-133 444.9 0.5 1.6 2 0 0 2 2 2 1 Peptidase family M3 Voltage_CLC PF00654.15 AMD19476.1 - 8.2e-85 284.9 24.3 1.5e-84 284.1 16.9 1.4 1 0 0 1 1 1 1 Voltage gated chloride channel DUF3091 PF11291.3 AMD19477.1 - 0.03 14.2 0.1 0.073 13.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3091) Nicastrin PF05450.10 AMD19477.1 - 0.076 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Nicastrin MT-A70 PF05063.9 AMD19478.1 - 1.5e-14 53.9 0.0 2.7e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 MT-A70 Spb1_C PF07780.7 AMD19479.1 - 1.2e-76 256.9 30.5 1.2e-76 256.9 21.1 3.3 3 0 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.3 AMD19479.1 - 2.6e-55 186.3 13.9 2.6e-55 186.3 9.7 5.3 4 1 0 5 5 5 1 Domain of unknown function (DUF3381) FtsJ PF01728.14 AMD19479.1 - 4.2e-52 176.7 0.1 1.1e-51 175.3 0.1 1.8 1 0 0 1 1 1 1 FtsJ-like methyltransferase PIG-X PF08320.7 AMD19480.1 - 8e-50 168.9 0.0 1.2e-49 168.4 0.0 1.3 1 0 0 1 1 1 1 PIG-X / PBN1 UCR_14kD PF02271.11 AMD19482.1 - 2e-43 146.4 0.0 2.3e-43 146.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit ATP_transf PF09830.4 AMD19483.1 - 1.8e-18 66.0 0.0 3.6e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.18 AMD19483.1 - 2.5e-06 27.9 0.0 1.3e-05 25.6 0.0 2.2 1 1 1 2 2 2 1 HIT domain Fumble PF03630.9 AMD19484.1 - 7.8e-118 393.2 2.4 3.5e-115 384.5 0.2 2.0 1 1 1 2 2 2 2 Fumble LRR_9 PF14580.1 AMD19485.1 - 0.012 15.1 0.7 0.14 11.7 0.1 2.4 2 0 0 2 2 2 0 Leucine-rich repeat GCV_H PF01597.14 AMD19485.1 - 0.033 13.8 1.3 0.12 12.0 0.8 1.9 2 0 0 2 2 2 0 Glycine cleavage H-protein DUF603 PF04645.7 AMD19485.1 - 3.9 7.3 10.9 0.89 9.4 3.0 2.5 1 1 1 2 2 2 0 Protein of unknown function, DUF603 Laminin_II PF06009.7 AMD19485.1 - 9 6.0 9.3 0.31 10.7 0.8 2.5 2 1 0 3 3 3 0 Laminin Domain II RPAP1_C PF08620.5 AMD19486.1 - 3.3e-30 103.7 0.0 6.3e-30 102.8 0.0 1.5 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 AMD19486.1 - 8.6e-17 60.4 1.4 2.1e-16 59.1 1.0 1.7 1 0 0 1 1 1 1 RPAP1-like, N-terminal Pmp3 PF01679.12 AMD19487.1 - 2.3e-12 46.3 2.6 2.8e-12 46.1 1.8 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator 7TM_GPCR_Sri PF10327.4 AMD19487.1 - 0.079 11.9 0.8 0.091 11.7 0.6 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri DUF4418 PF14387.1 AMD19487.1 - 0.081 12.6 0.1 0.091 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4418) PrgI PF12666.2 AMD19487.1 - 0.089 12.9 0.3 0.11 12.6 0.2 1.1 1 0 0 1 1 1 0 PrgI family protein ArfGap PF01412.13 AMD19489.1 - 4e-28 97.5 0.2 1.2e-27 95.9 0.2 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.24 AMD19489.1 - 1.2e-14 54.3 1.9 5.7e-13 48.9 0.2 2.9 2 1 0 2 2 2 1 PH domain PH_9 PF15410.1 AMD19489.1 - 0.002 18.2 0.3 0.0062 16.6 0.2 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 AMD19489.1 - 0.028 14.4 0.3 0.07 13.2 0.2 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PH_7 PF15408.1 AMD19489.1 - 0.032 14.1 0.1 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.1 AMD19489.1 - 0.15 12.2 3.3 1.7 8.9 2.3 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain Pkinase PF00069.20 AMD19490.1 - 2.9e-68 229.8 0.0 3.9e-68 229.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19490.1 - 9.6e-47 159.2 0.0 1.4e-46 158.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19490.1 - 2.7e-06 26.5 0.0 8.4e-05 21.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like DUF4404 PF14357.1 AMD19490.1 - 0.052 13.9 0.1 0.14 12.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Recep_L_domain PF01030.19 AMD19491.1 - 3.4e-10 39.8 6.5 0.00032 20.6 0.1 4.0 2 1 2 4 4 4 4 Receptor L domain Zn_clus PF00172.13 AMD19492.1 - 1.2e-05 25.0 11.6 2.5e-05 24.0 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1620 PF07774.8 AMD19493.1 - 3.5e-74 248.7 3.5 9.4e-74 247.3 2.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 AMD19493.1 - 0.00014 21.4 0.1 0.045 13.2 0.0 3.0 2 1 0 3 3 3 2 PQQ-like domain PQQ PF01011.16 AMD19493.1 - 0.0084 15.6 0.1 0.04 13.4 0.0 2.1 2 0 0 2 2 2 1 PQQ enzyme repeat Mgr1 PF08602.5 AMD19494.1 - 1.4e-129 432.2 0.0 1.9e-129 431.8 0.0 1.1 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit Thioredoxin PF00085.15 AMD19495.1 - 1.8e-58 194.6 0.2 1.9e-29 101.4 0.0 3.5 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.1 AMD19495.1 - 4.5e-28 98.2 6.7 4.7e-21 75.4 0.6 3.7 3 1 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_2 PF13098.1 AMD19495.1 - 3.2e-10 40.1 3.2 0.00049 20.2 0.1 4.3 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 AMD19495.1 - 3.3e-09 36.6 0.1 0.00091 19.2 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 AMD19495.1 - 7.3e-08 32.4 0.3 0.018 15.1 0.0 3.7 3 2 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.16 AMD19495.1 - 1.6e-06 27.7 0.1 0.00091 18.9 0.0 2.8 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.5 AMD19495.1 - 5.2e-06 26.0 0.2 0.013 15.0 0.0 2.5 2 0 0 2 2 2 2 Redoxin Thioredoxin_4 PF13462.1 AMD19495.1 - 0.00061 19.8 2.0 0.21 11.5 0.0 3.8 3 1 0 3 3 3 1 Thioredoxin Thioredoxin_5 PF13743.1 AMD19495.1 - 0.0022 17.5 0.0 0.019 14.5 0.0 2.7 4 0 0 4 4 4 1 Thioredoxin GRASP55_65 PF04495.9 AMD19496.1 - 1.5e-34 118.9 0.0 5e-34 117.2 0.0 1.7 1 1 1 2 2 2 1 GRASP55/65 PDZ-like domain Hexokinase_2 PF03727.11 AMD19497.1 - 4.6e-86 287.9 0.0 6.5e-86 287.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 AMD19497.1 - 2.1e-69 232.9 0.2 8.9e-69 230.9 0.1 1.9 2 0 0 2 2 2 1 Hexokinase WD40 PF00400.27 AMD19498.1 - 2.5e-24 84.2 7.1 7.2e-05 22.5 0.1 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat BBS2_N PF14781.1 AMD19498.1 - 0.0017 17.9 0.1 0.48 10.0 0.0 3.2 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, N-terminal Apc4_WD40 PF12894.2 AMD19498.1 - 0.0068 15.8 0.1 17 4.9 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.1 AMD19498.1 - 0.021 13.9 0.0 0.27 10.3 0.0 2.3 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Lactonase PF10282.4 AMD19498.1 - 0.033 13.2 0.3 0.37 9.8 0.0 2.1 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller ATG22 PF11700.3 AMD19499.1 - 3.2e-155 517.2 28.4 3.7e-155 517.0 19.7 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 AMD19499.1 - 9.5e-07 27.8 35.6 2.7e-06 26.3 4.9 3.2 1 1 2 3 3 3 2 Major Facilitator Superfamily La PF05383.12 AMD19500.1 - 2.5e-19 68.8 0.2 1.6e-18 66.2 0.0 2.5 4 0 0 4 4 4 1 La domain TRCF PF03461.10 AMD19501.1 - 0.014 15.3 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 TRCF domain DUF3800 PF12686.2 AMD19501.1 - 0.045 13.3 0.2 0.15 11.6 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Glutaredoxin PF00462.19 AMD19502.1 - 8.2e-14 51.3 0.0 1.3e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.1 AMD19502.1 - 0.0029 17.5 0.0 0.0038 17.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_4 PF13462.1 AMD19502.1 - 0.028 14.4 0.4 0.85 9.6 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin Thyroglobulin_1 PF00086.13 AMD19502.1 - 0.046 13.0 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 Thyroglobulin type-1 repeat Thioredoxin_2 PF13098.1 AMD19502.1 - 0.12 12.5 0.1 0.2 11.8 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like domain GAT PF03127.9 AMD19503.1 - 2.9e-05 23.9 0.0 7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 GAT domain SelR PF01641.13 AMD19504.1 - 1.1e-51 173.6 0.9 1.3e-51 173.4 0.6 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.9 AMD19504.1 - 0.0096 15.9 2.2 0.033 14.2 1.5 1.9 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HECT_2 PF09814.4 AMD19504.1 - 0.027 13.1 1.9 0.25 9.9 0.2 2.0 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF2296 PF10058.4 AMD19504.1 - 0.053 13.2 2.4 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Endonuclease_7 PF02945.10 AMD19504.1 - 0.32 10.7 5.3 2.2 8.0 3.7 2.0 1 1 0 1 1 1 0 Recombination endonuclease VII DZR PF12773.2 AMD19504.1 - 6 6.7 8.3 2.8 7.8 0.3 2.3 1 1 1 2 2 2 0 Double zinc ribbon DUF3128 PF11326.3 AMD19505.1 - 1.3e-27 95.6 1.8 1.5e-27 95.5 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) CHCH PF06747.8 AMD19505.1 - 0.019 14.8 0.8 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 CHCH domain Adeno_VII PF03228.9 AMD19505.1 - 0.035 14.6 1.0 0.1 13.1 0.1 1.9 2 0 0 2 2 2 0 Adenoviral core protein VII RA PF00788.18 AMD19506.1 - 2.3e-16 60.0 0.1 1.1e-15 57.8 0.0 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Ste50p-SAM PF09235.5 AMD19506.1 - 3.7e-14 52.5 2.2 5.4e-08 32.7 0.1 2.5 2 0 0 2 2 2 2 Ste50p, sterile alpha motif MbeD_MobD PF04899.7 AMD19506.1 - 0.035 13.9 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 MbeD/MobD like SAM_1 PF00536.25 AMD19506.1 - 0.036 14.2 0.1 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF948 PF06103.6 AMD19506.1 - 0.39 10.6 2.4 0.56 10.1 0.8 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RRP7 PF12923.2 AMD19507.1 - 3.9e-32 111.0 6.6 5.9e-32 110.4 4.6 1.3 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) DUF814 PF05670.8 AMD19507.1 - 0.031 14.1 0.0 0.063 13.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF814) Complex1_LYR PF05347.10 AMD19508.1 - 4.1e-09 36.0 0.1 9.3e-09 34.9 0.0 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 AMD19508.1 - 1.1e-08 35.1 0.0 2.1e-08 34.2 0.0 1.5 2 0 0 2 2 2 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 AMD19508.1 - 1.4e-06 28.7 0.1 1.9e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like PMT_C PF11647.3 AMD19508.1 - 0.061 12.9 0.2 0.27 10.8 0.0 1.9 2 0 0 2 2 2 0 C-terminal region of Pasteurella multocida toxin residues 569-1285 DUF4028 PF13220.1 AMD19508.1 - 0.072 12.7 0.5 0.15 11.6 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4028) Histidinol_dh PF00815.15 AMD19509.1 - 1.5e-180 600.2 4.4 2.1e-180 599.7 3.0 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.13 AMD19509.1 - 1.6e-26 91.7 0.1 3.4e-26 90.6 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 AMD19509.1 - 7.8e-11 42.1 0.2 2.6e-10 40.4 0.1 1.9 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase CAP_GLY PF01302.20 AMD19510.1 - 3.8e-14 52.1 0.8 1e-13 50.7 0.6 1.7 1 0 0 1 1 1 1 CAP-Gly domain GAS PF13851.1 AMD19510.1 - 0.0032 16.7 31.5 0.04 13.1 14.1 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Dict-STAT-coil PF09267.5 AMD19510.1 - 0.0073 16.5 1.5 0.0073 16.5 1.0 2.4 1 1 1 2 2 2 1 Dictyostelium STAT, coiled coil Seryl_tRNA_N PF02403.17 AMD19510.1 - 0.039 13.9 1.6 0.039 13.9 1.1 3.4 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ORF6N PF10543.4 AMD19510.1 - 0.46 10.5 6.3 0.071 13.1 1.4 1.9 2 0 0 2 2 2 0 ORF6N domain PilJ PF13675.1 AMD19510.1 - 0.9 9.8 9.9 2.9 8.2 1.5 2.7 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF4200 PF13863.1 AMD19510.1 - 1.1 9.2 34.3 0.71 9.8 12.3 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) APG6 PF04111.7 AMD19510.1 - 1.9 7.4 30.9 2.9 6.8 13.9 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 TPR_11 PF13414.1 AMD19511.1 - 0.017 14.7 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 TPR repeat Dak2 PF02734.12 AMD19511.1 - 0.74 9.4 8.1 0.061 12.9 0.4 2.0 1 1 1 2 2 2 0 DAK2 domain CAP PF00188.21 AMD19512.1 - 1.8e-17 64.0 0.0 2.5e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SH3_9 PF14604.1 AMD19513.1 - 6.2e-06 25.7 0.0 1.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 AMD19513.1 - 0.0032 16.8 0.0 0.0062 15.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SKG6 PF08693.5 AMD19513.1 - 0.0041 16.3 0.9 0.0076 15.5 0.6 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain SH3_2 PF07653.12 AMD19513.1 - 0.025 14.0 0.0 0.061 12.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Rax2 PF12768.2 AMD19513.1 - 0.07 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF485 PF04341.7 AMD19513.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 AA_permease PF00324.16 AMD19514.1 - 6.6e-127 423.7 33.6 7.7e-127 423.5 23.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD19514.1 - 2.6e-30 105.3 33.0 3.2e-30 105.0 22.9 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2207 PF09972.4 AMD19514.1 - 0.58 8.6 14.5 2.1 6.8 0.0 3.6 2 2 1 3 3 3 0 Predicted membrane protein (DUF2207) Rad60-SLD PF11976.3 AMD19515.1 - 4.4e-20 71.1 0.1 5.7e-20 70.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 AMD19515.1 - 8.5e-10 37.8 0.0 1.1e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Pkinase PF00069.20 AMD19516.1 - 6.8e-73 245.0 0.0 1.9e-72 243.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19516.1 - 1.1e-35 122.9 0.0 2.2e-35 122.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19516.1 - 1.5e-05 24.1 0.0 6.4e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 AMD19516.1 - 4.7 6.8 5.2 0.69 9.6 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Cu-oxidase_2 PF07731.9 AMD19517.1 - 1.5e-33 115.1 7.0 7.1e-28 96.8 1.1 3.5 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.10 AMD19517.1 - 2.7e-25 88.3 4.4 1.6e-24 85.8 0.5 3.1 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.17 AMD19517.1 - 3.5e-25 88.7 0.3 3.4e-24 85.5 0.1 2.5 2 1 0 2 2 2 1 Multicopper oxidase PSP1 PF04468.7 AMD19518.1 - 6.3e-35 119.0 0.0 1.6e-34 117.7 0.0 1.7 1 0 0 1 1 1 1 PSP1 C-terminal conserved region PBP PF01161.15 AMD19519.1 - 3.9e-26 91.6 0.0 4.7e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PAP2 PF01569.16 AMD19520.1 - 4e-22 78.2 4.0 8.1e-22 77.2 2.8 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.1 AMD19520.1 - 0.0018 18.5 2.7 0.011 15.9 1.1 2.7 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2_3 PF14378.1 AMD19520.1 - 0.051 13.1 6.0 0.014 14.9 1.8 1.8 2 0 0 2 2 2 0 PAP2 superfamily S-AdoMet_synt_C PF02773.11 AMD19521.1 - 8.3e-74 245.8 0.1 1.3e-73 245.1 0.1 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 AMD19521.1 - 5.8e-47 158.5 0.0 1.1e-46 157.6 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 AMD19521.1 - 1.6e-44 150.1 0.1 2.8e-44 149.3 0.1 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain DUF605 PF04652.11 AMD19522.1 - 2e-43 149.2 0.9 1.9e-28 99.9 0.0 2.0 1 1 1 2 2 2 2 Vta1 like DASH_Spc34 PF08657.5 AMD19522.1 - 0.12 12.0 6.6 0.26 10.8 4.6 1.5 1 0 0 1 1 1 0 DASH complex subunit Spc34 ARGLU PF15346.1 AMD19522.1 - 1.3 8.7 16.5 0.074 12.8 6.8 2.0 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Ank_5 PF13857.1 AMD19523.1 - 4.2e-15 55.4 0.2 3.1e-07 30.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD19523.1 - 2.8e-13 50.0 0.0 1.6e-05 25.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 AMD19523.1 - 4.8e-13 48.2 0.4 9.1e-07 28.3 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 AMD19523.1 - 6.5e-13 47.5 0.8 1.5e-05 24.7 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 AMD19523.1 - 4.3e-09 36.6 0.5 0.0013 19.2 0.0 3.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Tropomyosin_1 PF12718.2 AMD19523.1 - 0.038 13.8 15.8 0.58 9.9 0.4 2.6 2 0 0 2 2 2 0 Tropomyosin like IncA PF04156.9 AMD19523.1 - 0.39 10.2 10.1 0.56 9.7 1.5 2.3 2 0 0 2 2 2 0 IncA protein PP1_inhibitor PF05361.7 AMD19523.1 - 0.89 9.2 9.9 0.061 13.0 0.9 2.7 2 1 0 2 2 2 0 PKC-activated protein phosphatase-1 inhibitor Nup54 PF13874.1 AMD19523.1 - 1.6 8.3 10.0 8.6 6.0 0.2 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF342 PF03961.8 AMD19523.1 - 3.6 5.8 7.9 5 5.4 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) FHA PF00498.21 AMD19524.1 - 1.4e-05 25.1 0.0 3.5e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 FHA domain Pox_RNA_Pol_19 PF05320.7 AMD19524.1 - 3.3 7.4 11.4 0.92 9.2 0.9 3.0 3 0 0 3 3 3 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Ribosomal_L37e PF01907.14 AMD19525.1 - 2.2e-28 97.8 11.4 2.2e-28 97.8 7.9 1.4 2 0 0 2 2 2 1 Ribosomal protein L37e DZR PF12773.2 AMD19525.1 - 0.00059 19.6 1.6 0.00089 19.0 1.1 1.2 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.13 AMD19525.1 - 0.0092 15.6 0.4 0.012 15.3 0.3 1.2 1 1 0 1 1 1 1 SelR domain C1_1 PF00130.17 AMD19525.1 - 0.04 13.6 2.5 0.066 12.9 1.8 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_6 PF14599.1 AMD19525.1 - 0.044 13.5 2.0 0.068 12.9 1.4 1.2 1 0 0 1 1 1 0 Zinc-ribbon GATA PF00320.22 AMD19525.1 - 0.17 11.2 6.2 0.56 9.5 1.0 2.4 1 1 1 2 2 2 0 GATA zinc finger zinc_ribbon_2 PF13240.1 AMD19525.1 - 0.38 10.3 4.4 2.3 7.8 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 AMD19525.1 - 0.42 9.8 4.6 3.2 7.0 3.2 2.1 1 1 1 2 2 2 0 zinc-ribbon domain zf-C3HC4 PF00097.20 AMD19525.1 - 2 8.1 5.6 3.2 7.4 3.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HYPF PF07503.7 AMD19525.1 - 2.7 7.4 6.1 3.4 7.1 1.9 2.1 1 1 1 2 2 2 0 HypF finger DUF2256 PF10013.4 AMD19525.1 - 7.7 6.3 7.1 4.3 7.1 1.0 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) LCD1 PF09798.4 AMD19526.1 - 2.3e-186 620.6 16.2 2.9e-186 620.3 11.3 1.1 1 0 0 1 1 1 1 DNA damage checkpoint protein ATG16 PF08614.6 AMD19526.1 - 0.0051 16.6 6.6 0.009 15.8 4.6 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Macoilin PF09726.4 AMD19526.1 - 0.24 9.6 5.5 0.34 9.1 3.8 1.1 1 0 0 1 1 1 0 Transmembrane protein IncA PF04156.9 AMD19526.1 - 1.3 8.5 10.8 3.3 7.2 7.5 1.6 1 0 0 1 1 1 0 IncA protein DUF342 PF03961.8 AMD19526.1 - 3.1 6.1 5.8 4.9 5.4 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) EMG1 PF03587.9 AMD19527.1 - 6.2e-78 260.7 0.0 7.3e-78 260.4 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase SecE PF00584.15 AMD19528.1 - 4 7.0 14.2 0.36 10.4 0.1 3.9 3 1 1 4 4 4 0 SecE/Sec61-gamma subunits of protein translocation complex PH PF00169.24 AMD19529.1 - 4.5e-10 39.6 0.0 1.2e-07 31.8 0.0 2.7 2 0 0 2 2 2 2 PH domain ABC_membrane PF00664.18 AMD19530.1 - 1.4e-58 198.5 6.6 1.7e-58 198.2 4.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 AMD19530.1 - 2.2e-32 112.2 0.0 7.1e-32 110.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.14 AMD19530.1 - 1.5e-08 34.1 0.2 2e-06 27.2 0.0 2.4 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 AMD19530.1 - 9.1e-06 26.4 0.0 2.6e-05 25.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 AMD19530.1 - 3.3e-05 23.9 0.0 8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 AMD19530.1 - 0.00057 20.0 0.1 0.0046 17.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 AMD19530.1 - 0.00066 19.1 0.1 0.33 10.3 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_21 PF13304.1 AMD19530.1 - 0.00087 19.3 0.0 0.7 9.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 AMD19530.1 - 0.0012 19.0 0.2 0.032 14.4 0.2 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 AMD19530.1 - 0.0041 16.3 0.0 0.0084 15.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_5 PF07728.9 AMD19530.1 - 0.0055 16.4 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.4 AMD19530.1 - 0.01 14.4 0.1 0.02 13.5 0.1 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Zeta_toxin PF06414.7 AMD19530.1 - 0.011 14.8 0.0 0.023 13.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 AMD19530.1 - 0.015 15.5 0.0 0.05 13.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 AMD19530.1 - 0.016 14.6 0.1 0.067 12.6 0.1 1.9 1 1 1 2 2 2 0 AAA-like domain AAA_29 PF13555.1 AMD19530.1 - 0.034 13.6 0.0 0.08 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 AMD19530.1 - 0.04 13.3 0.1 0.22 10.8 0.0 2.1 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.1 AMD19530.1 - 0.068 13.0 0.3 0.35 10.8 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.1 AMD19530.1 - 0.17 11.7 2.4 0.72 9.7 0.6 2.5 2 1 0 2 2 1 0 AAA domain DUF4282 PF14110.1 AMD19530.1 - 0.18 12.0 0.0 0.18 12.0 0.0 2.5 3 0 0 3 3 2 0 Domain of unknown function (DUF4282) Abhydrolase_1 PF00561.15 AMD19531.1 - 1.4e-48 165.4 0.5 3.2e-47 161.0 0.4 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 AMD19531.1 - 8.9e-13 48.6 0.4 5e-12 46.1 0.3 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AMD19531.1 - 0.00031 20.5 0.9 0.024 14.3 0.7 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 AMD19531.1 - 0.0064 16.3 0.1 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 TAP-like protein Esterase PF00756.15 AMD19531.1 - 0.029 13.7 0.8 0.057 12.8 0.2 1.7 2 0 0 2 2 2 0 Putative esterase Abhydrolase_2 PF02230.11 AMD19531.1 - 0.083 12.3 0.2 0.76 9.1 0.1 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase GRAM PF02893.15 AMD19532.1 - 8.2e-26 89.3 1.1 1.7e-15 56.2 0.1 2.8 2 0 0 2 2 2 2 GRAM domain Glyco_transf_28 PF03033.15 AMD19532.1 - 2e-25 89.1 0.0 4.6e-25 87.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 AMD19532.1 - 9.9e-10 37.5 0.0 2.6e-09 36.1 0.0 1.6 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH PF00169.24 AMD19532.1 - 3e-06 27.3 2.8 1.1e-05 25.5 0.4 3.0 1 1 2 3 3 3 1 PH domain Exo_endo_phos PF03372.18 AMD19533.1 - 5.4e-17 62.5 0.6 7.4e-17 62.1 0.4 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Wzy_C PF04932.10 AMD19533.1 - 1.8 8.3 6.7 3.7 7.3 4.7 1.5 1 1 0 1 1 1 0 O-Antigen ligase Spindle_Spc25 PF08234.7 AMD19534.1 - 3.9e-17 62.0 0.0 9.7e-17 60.7 0.0 1.7 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 DUF972 PF06156.8 AMD19534.1 - 0.0077 16.5 7.9 0.0077 16.5 5.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF972) V_ATPase_I PF01496.14 AMD19534.1 - 0.0096 13.8 8.2 0.011 13.5 5.7 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family APG6 PF04111.7 AMD19534.1 - 0.017 14.2 17.2 0.023 13.7 12.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 PV-1 PF06637.6 AMD19534.1 - 0.03 12.8 12.9 0.04 12.4 8.9 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Bacillus_HBL PF05791.6 AMD19534.1 - 0.039 13.3 9.3 0.055 12.8 6.4 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF4337 PF14235.1 AMD19534.1 - 0.82 9.4 14.6 0.043 13.6 2.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF2730 PF10805.3 AMD19534.1 - 0.94 9.2 8.5 0.96 9.2 4.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) ADIP PF11559.3 AMD19534.1 - 1.5 8.6 21.9 3.4 7.5 15.2 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding AAA_11 PF13086.1 AMD19534.1 - 1.5 8.3 6.8 2.8 7.4 4.7 1.4 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.1 AMD19534.1 - 3.6 6.4 8.9 4.9 6.0 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HAUS6_N PF14661.1 AMD19534.1 - 4 6.7 14.7 0.51 9.6 4.4 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF342 PF03961.8 AMD19534.1 - 4.6 5.5 10.7 6.1 5.1 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.9 AMD19534.1 - 6.8 6.2 24.5 22 4.5 16.7 1.9 1 1 0 1 1 1 0 IncA protein Osmo_CC PF08946.5 AMD19534.1 - 8 6.5 13.9 1 9.4 0.6 3.4 2 1 1 3 3 3 0 Osmosensory transporter coiled coil Per1 PF04080.8 AMD19535.1 - 3.9e-91 305.1 17.6 4.7e-91 304.9 12.2 1.1 1 0 0 1 1 1 1 Per1-like TcpE PF12648.2 AMD19535.1 - 0.03 14.4 1.0 0.03 14.4 0.7 2.8 3 0 0 3 3 3 0 TcpE family PAN_2 PF08276.6 AMD19535.1 - 1 9.2 5.1 1.2 9.0 0.7 2.3 2 0 0 2 2 2 0 PAN-like domain Ole-e-6 PF09253.5 AMD19535.1 - 3.6 7.3 8.9 0.048 13.3 1.1 1.7 2 0 0 2 2 2 0 Pollen allergen ole e 6 HCO3_cotransp PF00955.16 AMD19536.1 - 4.8e-62 210.2 13.8 1.8e-34 119.2 3.1 2.1 1 1 1 2 2 2 2 HCO3- transporter family Peptidase_M1 PF01433.15 AMD19538.1 - 1.2e-09 37.8 0.8 0.00065 18.8 0.0 3.4 3 0 0 3 3 3 3 Peptidase family M1 DUF4379 PF14311.1 AMD19538.1 - 0.076 12.8 2.6 0.2 11.4 1.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) Sad1_UNC PF07738.8 AMD19539.1 - 9.2e-34 116.1 0.0 2e-33 115.0 0.0 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Cyclin_N PF00134.18 AMD19540.1 - 1.6e-37 127.9 0.6 3.5e-36 123.5 0.4 2.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain zf-C2H2_jaz PF12171.3 AMD19540.1 - 0.013 15.6 0.3 0.029 14.4 0.2 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 AMD19540.1 - 0.02 15.1 0.4 0.12 12.5 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type TIMELESS PF04821.9 AMD19541.1 - 2.3e-48 164.7 0.6 8.5e-48 162.9 0.4 2.1 1 0 0 1 1 1 1 Timeless protein Aa_trans PF01490.13 AMD19542.1 - 6.4e-76 255.4 35.5 7.3e-76 255.2 24.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Sec2p PF06428.6 AMD19543.1 - 2.4e-26 91.4 13.4 2.4e-26 91.4 9.3 3.1 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p Myosin_tail_1 PF01576.14 AMD19543.1 - 0.0036 15.0 28.0 0.0048 14.6 19.4 1.1 1 0 0 1 1 1 1 Myosin tail Tropomyosin_1 PF12718.2 AMD19543.1 - 0.0053 16.6 19.4 0.0053 16.6 13.5 2.4 1 1 1 2 2 2 1 Tropomyosin like Laminin_II PF06009.7 AMD19543.1 - 0.0083 15.8 5.0 0.0083 15.8 3.4 3.0 1 1 2 3 3 3 1 Laminin Domain II DUF2959 PF11172.3 AMD19543.1 - 0.017 14.9 14.7 0.023 14.4 9.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) DUF745 PF05335.8 AMD19543.1 - 0.026 14.0 16.0 0.058 12.9 10.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF745) LMBR1 PF04791.11 AMD19543.1 - 0.077 11.5 0.9 0.12 10.9 0.6 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Tubulin_C PF03953.12 AMD19543.1 - 0.092 12.7 0.3 0.2 11.6 0.2 1.5 1 0 0 1 1 1 0 Tubulin C-terminal domain Reo_sigmaC PF04582.7 AMD19543.1 - 0.1 11.7 6.7 0.24 10.5 4.6 1.7 1 0 0 1 1 1 0 Reovirus sigma C capsid protein GAS PF13851.1 AMD19543.1 - 0.46 9.6 26.7 0.84 8.7 18.5 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_27 PF13514.1 AMD19543.1 - 0.59 7.7 22.0 1.7 6.2 15.1 1.6 1 1 0 1 1 1 0 AAA domain CorA PF01544.13 AMD19543.1 - 0.6 9.0 12.2 0.079 11.9 5.1 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein CDC37_N PF03234.9 AMD19543.1 - 2.5 8.4 23.1 0.92 9.7 13.7 1.9 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding UPF0242 PF06785.6 AMD19543.1 - 2.9 6.4 20.3 7.3 5.1 13.1 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) PEP-utilisers_N PF05524.8 AMD19543.1 - 4.6 7.0 7.4 9.2 6.0 5.1 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal FUSC PF04632.7 AMD19543.1 - 6.4 5.0 4.3 8.8 4.6 3.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ApoO PF09769.4 AMD19543.1 - 8.2 6.1 9.6 16 5.1 4.5 2.6 1 1 1 2 2 2 0 Apolipoprotein O AAA_13 PF13166.1 AMD19543.1 - 8.8 4.6 22.0 14 3.9 15.3 1.2 1 0 0 1 1 1 0 AAA domain FH2 PF02181.18 AMD19544.1 - 4.7e-82 275.8 9.1 4.7e-82 275.8 6.3 3.4 4 0 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.11 AMD19544.1 - 2.4e-45 154.3 18.0 2.8e-45 154.1 0.0 4.5 4 0 0 4 4 4 2 Diaphanous FH3 Domain Drf_GBD PF06371.8 AMD19544.1 - 1.6e-29 102.6 0.3 1.6e-29 102.6 0.2 3.8 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain AA_permease PF00324.16 AMD19545.1 - 4.2e-136 454.0 43.4 5.2e-136 453.7 30.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD19545.1 - 1.9e-30 105.7 54.1 1.1e-29 103.2 37.7 1.8 1 1 0 1 1 1 1 Amino acid permease Peptidase_M50 PF02163.17 AMD19545.1 - 0.081 11.8 1.2 5 6.0 1.5 2.7 3 1 0 3 3 3 0 Peptidase family M50 AA_permease PF00324.16 AMD19546.1 - 4.9e-127 424.1 41.9 5.5e-127 424.0 29.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD19546.1 - 2.1e-34 118.7 46.8 2.6e-34 118.5 32.5 1.1 1 0 0 1 1 1 1 Amino acid permease PI3_PI4_kinase PF00454.22 AMD19547.1 - 2.4e-33 115.5 0.1 5.6e-33 114.3 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.3 AMD19547.1 - 2.1e-18 65.7 0.3 6.3e-18 64.2 0.2 1.9 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.15 AMD19547.1 - 8.6e-07 28.3 1.1 2.1e-06 27.0 0.8 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Mmp37 PF09139.6 AMD19548.1 - 5.7e-102 341.1 15.5 8.2e-95 317.5 3.3 2.4 2 1 1 3 3 3 2 Mitochondrial matrix Mmp37 Med17 PF10156.4 AMD19548.1 - 0.01 14.1 0.1 0.08 11.2 0.0 2.0 2 0 0 2 2 2 0 Subunit 17 of Mediator complex Ist1 PF03398.9 AMD19549.1 - 7e-52 175.1 2.2 9.8e-52 174.6 1.5 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway TPR_16 PF13432.1 AMD19550.1 - 2.7e-17 62.9 6.8 0.00033 21.2 0.1 6.9 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 AMD19550.1 - 5.6e-14 51.5 20.8 6.6e-05 22.4 0.0 7.7 6 2 2 8 8 8 5 TPR repeat TPR_19 PF14559.1 AMD19550.1 - 2.3e-13 50.2 6.5 8.9e-05 22.7 0.3 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 AMD19550.1 - 4.2e-11 42.4 0.9 0.35 11.6 0.0 6.7 6 2 2 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 AMD19550.1 - 1.7e-10 40.6 15.1 0.028 14.3 0.0 7.2 6 2 1 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.12 AMD19550.1 - 6.6e-10 38.1 14.1 1.3 9.0 0.0 9.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_6 PF13174.1 AMD19550.1 - 9.1e-09 35.2 1.7 0.27 11.7 0.0 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 AMD19550.1 - 3.6e-08 32.9 17.5 0.042 14.0 0.3 8.2 10 0 0 10 10 7 3 Tetratricopeptide repeat TPR_20 PF14561.1 AMD19550.1 - 5.7e-06 26.3 4.4 0.32 11.1 0.2 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.1 AMD19550.1 - 1.9e-05 24.4 0.1 1.5 8.7 0.0 4.2 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 AMD19550.1 - 7.8e-05 22.1 24.7 1.8 8.3 0.0 8.5 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_15 PF13429.1 AMD19550.1 - 8.5e-05 21.7 0.9 1 8.3 0.1 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 AMD19550.1 - 0.00085 18.9 16.0 0.048 13.4 0.2 7.9 7 1 1 8 8 8 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 AMD19550.1 - 0.015 15.4 1.2 0.45 10.7 0.1 2.5 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Pox_polyA_pol_N PF12630.2 AMD19550.1 - 0.024 14.7 4.1 0.092 12.8 0.1 3.1 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain Tau95 PF09734.4 AMD19550.1 - 0.048 12.9 0.8 0.32 10.2 0.0 2.3 1 1 1 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit TPPII_N PF12583.3 AMD19550.1 - 0.093 12.8 1.1 11 6.1 0.0 2.6 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal TPR_10 PF13374.1 AMD19550.1 - 0.24 11.4 6.1 10 6.1 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat UFD1 PF03152.9 AMD19551.1 - 6.2e-72 240.4 0.0 7.9e-72 240.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CRAL_TRIO PF00650.15 AMD19552.1 - 1.9e-39 134.7 0.1 3e-39 134.0 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 AMD19552.1 - 1.5e-10 41.0 0.1 6.5e-10 38.9 0.0 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 AMD19552.1 - 2.8e-06 27.2 0.1 4.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain UBA_4 PF14555.1 AMD19552.1 - 0.00094 18.6 0.0 0.0038 16.7 0.0 1.9 2 0 0 2 2 2 1 UBA-like domain UBA PF00627.26 AMD19552.1 - 0.11 12.3 0.1 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 UBA/TS-N domain DnaJ PF00226.26 AMD19553.1 - 2.5e-15 55.9 0.5 4.3e-15 55.2 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain YIF1 PF03878.10 AMD19554.1 - 2.6e-69 233.0 8.4 3.4e-69 232.6 5.8 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 AMD19554.1 - 6.7 6.1 12.3 0.027 13.9 2.2 1.6 2 0 0 2 2 2 0 Yip1 domain DUF1744 PF08490.7 AMD19555.1 - 4.1e-148 493.1 1.3 6.8e-148 492.4 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.14 AMD19555.1 - 1.3e-67 227.9 0.6 4.7e-67 226.1 0.4 2.0 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 AMD19555.1 - 7.1e-24 84.4 6.5 2e-22 79.5 1.5 2.4 2 0 0 2 2 2 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 AMD19555.1 - 1.1e-05 25.0 0.3 7.4e-05 22.3 0.2 2.4 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Phos_pyr_kin PF08543.7 AMD19555.1 - 0.35 10.0 0.0 0.65 9.1 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase ORC5_C PF14630.1 AMD19556.1 - 4.4e-67 226.3 1.2 5.9e-67 225.9 0.8 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 AMD19556.1 - 1.1e-07 31.9 0.0 4.4e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 AMD19556.1 - 8.4e-05 22.7 0.0 0.00021 21.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AMD19556.1 - 0.00027 20.8 1.0 0.0038 17.1 0.7 2.5 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 AMD19556.1 - 0.00037 20.2 0.4 0.0012 18.5 0.0 2.0 2 0 0 2 2 2 1 Archaeal ATPase GYF PF02213.11 AMD19557.1 - 4.9e-11 42.0 4.5 4.9e-11 42.0 3.1 2.0 2 0 0 2 2 2 1 GYF domain Yae1_N PF09811.4 AMD19558.1 - 1.6e-11 43.5 2.8 2.2e-11 43.0 1.9 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal HMA PF00403.21 AMD19559.1 - 2.5e-11 43.5 0.4 2.9e-11 43.3 0.3 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Gp_dh_C PF02800.15 AMD19559.1 - 0.017 14.5 0.2 0.033 13.6 0.1 1.5 1 1 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Fzo_mitofusin PF04799.8 AMD19559.1 - 0.078 12.3 0.1 0.087 12.1 0.1 1.0 1 0 0 1 1 1 0 fzo-like conserved region Dsl1_C PF11989.3 AMD19560.1 - 4e-107 357.7 14.6 4e-107 357.7 10.1 3.0 3 0 0 3 3 3 1 Retrograde transport protein Dsl1 C terminal Dsl1_N PF11988.3 AMD19560.1 - 1.9e-74 250.7 15.6 1.9e-74 250.7 10.8 2.3 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 N terminal NfI_DNAbd_pre-N PF10524.4 AMD19560.1 - 0.11 12.1 0.1 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 Nuclear factor I protein pre-N-terminus PH PF00169.24 AMD19561.1 - 8.1e-08 32.4 0.1 2.8e-07 30.6 0.1 2.0 1 0 0 1 1 1 1 PH domain DUF3287 PF11690.3 AMD19561.1 - 0.02 14.9 0.1 0.052 13.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) PGAP1 PF07819.8 AMD19562.1 - 9.1e-08 31.9 0.0 1.7e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 AMD19562.1 - 1.3e-06 27.8 0.0 2.9e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 Putative serine esterase (DUF676) DUF915 PF06028.6 AMD19562.1 - 6.7e-06 25.3 0.1 0.00021 20.4 0.0 2.7 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) LCAT PF02450.10 AMD19562.1 - 8.9e-05 21.6 0.1 0.00014 21.0 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 AMD19562.1 - 0.00034 20.5 0.0 0.00053 19.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD19562.1 - 0.0007 19.2 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AMD19562.1 - 0.045 13.4 0.0 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family Pro_isomerase PF00160.16 AMD19563.1 - 1.7e-14 54.3 0.0 2.5e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.17 AMD19563.1 - 1.8e-14 53.1 0.1 6.4e-14 51.3 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD19563.1 - 1.5e-11 44.1 0.1 5e-11 42.4 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD19563.1 - 2.6e-11 43.1 0.0 5.6e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_3 PF01494.14 AMD19564.1 - 5e-20 71.8 0.2 4.4e-13 49.0 0.0 3.1 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 AMD19564.1 - 0.00033 19.7 0.1 0.0036 16.2 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.19 AMD19564.1 - 0.00049 19.1 0.0 0.0037 16.2 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 AMD19564.1 - 0.001 17.7 0.1 0.021 13.4 0.1 2.2 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.1 AMD19564.1 - 0.0019 18.1 0.1 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 AMD19564.1 - 0.011 14.5 0.2 0.018 13.9 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.9 AMD19564.1 - 0.033 14.0 0.0 0.063 13.1 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 AMD19564.1 - 0.035 12.9 0.0 0.05 12.4 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase NAD_binding_9 PF13454.1 AMD19564.1 - 0.062 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.12 AMD19564.1 - 0.08 12.0 0.1 0.21 10.6 0.0 1.6 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.9 AMD19564.1 - 0.081 11.3 0.0 0.14 10.5 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein NARP1 PF12569.3 AMD19564.1 - 0.11 11.1 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 K_oxygenase PF13434.1 AMD19564.1 - 0.16 10.8 0.1 0.47 9.3 0.0 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pterin_bind PF00809.17 AMD19565.1 - 4.8e-41 140.4 0.0 2.4e-40 138.1 0.0 2.2 1 1 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.15 AMD19565.1 - 8.3e-39 132.2 0.0 2.2e-38 130.8 0.0 1.8 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.13 AMD19565.1 - 1.6e-35 121.6 0.6 4.1e-18 65.5 0.6 2.5 2 0 0 2 2 2 2 Dihydroneopterin aldolase zf-CCHC PF00098.18 AMD19566.1 - 1.4e-49 163.7 50.1 2.1e-08 33.7 0.6 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 AMD19566.1 - 2e-07 30.5 46.2 0.014 15.0 0.3 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.1 AMD19566.1 - 0.0029 17.2 43.0 2.2 8.0 0.7 7.1 2 2 4 6 6 6 5 Zinc knuckle zf-CCHC_2 PF13696.1 AMD19566.1 - 0.0039 16.6 4.8 0.036 13.5 0.2 7.0 2 2 5 7 7 7 4 Zinc knuckle PRP21_like_P PF12230.3 AMD19567.1 - 2.4e-30 105.7 16.7 2.2e-19 69.8 2.5 2.5 2 1 1 3 3 3 2 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 AMD19567.1 - 5.1e-07 29.2 0.6 1.4e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Surp module Lge1 PF11488.3 AMD19567.1 - 0.018 15.2 0.7 0.059 13.5 0.1 2.1 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 Sec10 PF07393.6 AMD19568.1 - 2.8e-42 144.8 11.4 2.5e-41 141.6 7.9 2.3 1 1 0 1 1 1 1 Exocyst complex component Sec10 Homeobox_KN PF05920.6 AMD19570.1 - 4.4e-07 29.5 0.4 4.4e-07 29.5 0.3 2.2 3 0 0 3 3 3 1 Homeobox KN domain Homeobox PF00046.24 AMD19570.1 - 8.6e-07 28.4 1.1 3.5e-06 26.5 0.2 2.3 2 0 0 2 2 2 1 Homeobox domain Homez PF11569.3 AMD19570.1 - 2.1e-05 23.4 0.1 4.5e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez HTH_28 PF13518.1 AMD19570.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain EST1_DNA_bind PF10373.4 AMD19570.1 - 0.033 13.3 0.1 0.038 13.1 0.1 1.2 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain HA PF03457.9 AMD19570.1 - 0.043 13.9 0.0 0.072 13.1 0.0 1.5 1 1 0 1 1 1 0 Helicase associated domain Muted PF14942.1 AMD19570.1 - 0.13 12.1 1.8 0.33 10.8 1.2 1.7 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein MAT_Alpha1 PF04769.7 AMD19571.1 - 6.6e-13 48.4 4.6 7.3e-09 35.2 0.2 2.7 1 1 2 3 3 3 3 Mating-type protein MAT alpha 1 SUI1 PF01253.17 AMD19572.1 - 7.9e-29 99.3 0.4 9.5e-29 99.0 0.3 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.3 AMD19572.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Cas_Csa5 PF09702.5 AMD19572.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) tRNA-synt_1e PF01406.14 AMD19573.1 - 5.9e-139 462.3 0.9 1e-138 461.5 0.6 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 AMD19573.1 - 6.1e-09 35.0 1.7 4.2e-06 25.6 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 AMD19573.1 - 1.6e-06 26.4 0.0 9.6e-06 23.8 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.16 AMD19573.1 - 0.015 13.9 2.3 0.018 13.6 0.0 2.3 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain DnaJ PF00226.26 AMD19574.1 - 2.1e-17 62.5 0.1 3.7e-17 61.8 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.8 AMD19574.1 - 2.9e-16 58.7 3.4 4.4e-16 58.1 2.3 1.3 1 0 0 1 1 1 1 CSL zinc finger Tyr-DNA_phospho PF06087.7 AMD19574.1 - 0.08 11.5 0.0 0.095 11.3 0.0 1.1 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase DUF866 PF05907.8 AMD19574.1 - 0.22 11.0 2.7 0.26 10.7 0.4 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF866) E7 PF00527.13 AMD19574.1 - 0.48 10.5 2.7 3.7 7.7 1.9 2.2 1 1 0 1 1 1 0 E7 protein, Early protein RNA_pol_I_A49 PF06870.7 AMD19575.1 - 6.8e-135 449.5 0.5 7.6e-135 449.3 0.3 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor PhageMin_Tail PF10145.4 AMD19575.1 - 0.067 12.8 3.8 0.044 13.4 0.7 2.0 2 0 0 2 2 2 0 Phage-related minor tail protein Zwint PF15556.1 AMD19575.1 - 0.075 12.2 0.0 0.66 9.1 0.0 2.2 2 0 0 2 2 2 0 ZW10 interactor AAA_23 PF13476.1 AMD19576.1 - 8.6e-30 104.5 0.1 8.6e-30 104.5 0.1 8.3 2 1 2 5 5 3 1 AAA domain SMC_N PF02463.14 AMD19576.1 - 1.9e-17 63.2 17.6 3.8e-09 36.1 4.4 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain Rad50_zn_hook PF04423.9 AMD19576.1 - 5.3e-13 48.2 3.7 5.3e-13 48.2 2.6 7.1 8 0 0 8 8 8 1 Rad50 zinc hook motif SbcCD_C PF13558.1 AMD19576.1 - 2.5e-10 40.1 0.0 7.2e-10 38.6 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.1 AMD19576.1 - 4.1e-08 32.1 137.1 5.5e-05 21.8 0.0 7.2 2 1 4 7 7 7 4 AAA domain AAA_21 PF13304.1 AMD19576.1 - 3.6e-07 30.4 1.1 0.00052 20.0 0.0 5.2 3 2 1 5 5 5 2 AAA domain Laminin_II PF06009.7 AMD19576.1 - 3.9e-05 23.4 16.2 7.5e-05 22.5 3.7 10.3 4 2 6 12 12 12 4 Laminin Domain II Tropomyosin_1 PF12718.2 AMD19576.1 - 0.00016 21.5 10.4 0.00016 21.5 7.2 8.1 4 3 4 8 8 5 1 Tropomyosin like MCPsignal PF00015.16 AMD19576.1 - 0.0013 18.3 3.4 0.0013 18.3 2.4 6.5 5 1 0 6 6 6 1 Methyl-accepting chemotaxis protein (MCP) signalling domain AAA_29 PF13555.1 AMD19576.1 - 0.0044 16.5 0.0 0.012 15.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 AMD19576.1 - 0.015 15.6 0.0 0.015 15.6 0.0 7.9 4 3 0 5 5 3 0 ABC transporter AAA_25 PF13481.1 AMD19576.1 - 0.085 12.2 2.7 5.8 6.2 0.0 3.7 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 AMD19576.1 - 0.16 11.7 0.1 0.42 10.3 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain NPV_P10 PF05531.7 AMD19576.1 - 0.17 12.1 48.3 0.038 14.2 0.5 9.8 6 3 2 8 8 8 0 Nucleopolyhedrovirus P10 protein AAA_16 PF13191.1 AMD19576.1 - 0.28 11.1 0.0 0.28 11.1 0.0 4.7 4 1 0 4 4 4 0 AAA ATPase domain AAA_27 PF13514.1 AMD19576.1 - 0.56 7.8 102.2 0.12 9.9 59.5 2.4 1 1 1 2 2 2 0 AAA domain RRM_1 PF00076.17 AMD19577.1 - 5.1e-08 32.4 0.0 1e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD19577.1 - 1.4e-07 31.4 0.0 2.9e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD19577.1 - 8.5e-05 22.3 0.0 0.00017 21.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.1 AMD19577.1 - 0.0069 15.8 0.0 0.019 14.4 0.0 1.7 1 0 0 1 1 1 1 Sporulation protein family 7 MRP-L46 PF11788.3 AMD19578.1 - 3e-35 121.2 0.2 5e-35 120.5 0.1 1.4 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 WD40 PF00400.27 AMD19579.1 - 3.4e-14 52.0 8.0 1.3e-05 24.8 0.2 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat Hira PF07569.6 AMD19579.1 - 0.017 14.3 0.0 1 8.5 0.0 2.3 2 0 0 2 2 2 0 TUP1-like enhancer of split HSP20 PF00011.16 AMD19580.1 - 3.6e-20 71.7 0.2 4.4e-20 71.4 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family RTC4 PF14474.1 AMD19581.1 - 1.7e-34 118.4 0.2 4.6e-34 117.0 0.0 1.8 2 0 0 2 2 2 1 RTC4-like domain DUF3649 PF12365.3 AMD19582.1 - 9.2 5.8 10.7 4.9 6.7 2.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3649) CRAL_TRIO_2 PF13716.1 AMD19583.1 - 2.9e-32 111.6 1.7 9.6e-32 109.9 1.2 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.22 AMD19583.1 - 2.5e-09 36.9 0.1 9.3e-09 35.0 0.1 1.9 1 1 0 1 1 1 1 RhoGAP domain RasGEF PF00617.14 AMD19584.1 - 1.5e-43 148.7 0.6 4.2e-43 147.2 0.4 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 AMD19584.1 - 9.6e-13 48.1 0.4 9.6e-13 48.1 0.3 3.7 4 0 0 4 4 4 1 RasGEF N-terminal motif SH3_1 PF00018.23 AMD19584.1 - 0.00021 20.6 0.1 0.00049 19.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 AMD19584.1 - 0.022 14.3 0.1 0.083 12.4 0.0 2.0 2 0 0 2 2 2 0 Variant SH3 domain SH3_2 PF07653.12 AMD19584.1 - 0.17 11.4 0.1 8.8 5.9 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain SPX PF03105.14 AMD19585.1 - 3.9e-44 151.5 10.1 5.4e-44 151.0 7.0 1.2 1 0 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 AMD19585.1 - 4.2e-24 85.2 51.1 5.8e-24 84.8 35.4 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 AMD19585.1 - 1.1e-15 57.0 52.1 1.7e-14 53.1 20.1 2.3 1 1 1 2 2 2 2 Citrate transporter UCH PF00443.24 AMD19586.1 - 2.9e-90 302.0 0.0 7e-90 300.7 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD19586.1 - 3.5e-18 66.0 9.0 1e-09 38.2 0.4 2.7 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 AMD19586.1 - 9.8e-05 22.6 0.3 0.00055 20.2 0.2 2.4 1 0 0 1 1 1 1 DUSP domain Rubredoxin PF00301.15 AMD19586.1 - 8.7 6.3 8.4 0.9 9.4 0.3 3.2 3 0 0 3 3 3 0 Rubredoxin PfkB PF00294.19 AMD19587.1 - 2.3e-45 155.0 0.5 5e-45 153.9 0.3 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase RNase_PH PF01138.16 AMD19588.1 - 1.1e-20 74.2 1.6 9.2e-19 68.0 1.0 2.8 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 ELO PF01151.13 AMD19589.1 - 1.1e-57 195.1 25.5 1.4e-57 194.9 17.7 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Keratin_assoc PF09775.4 AMD19589.1 - 0.6 9.6 5.7 1.3 8.6 1.6 2.2 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 Myb_DNA-binding PF00249.26 AMD19590.1 - 3.6e-16 58.9 0.0 2.1e-08 34.1 0.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD19590.1 - 2.7e-06 27.3 0.8 0.016 15.2 0.1 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Xan_ur_permease PF00860.15 AMD19591.1 - 5.5e-63 212.7 30.0 7.9e-63 212.2 20.8 1.2 1 0 0 1 1 1 1 Permease family WD40 PF00400.27 AMD19593.1 - 7e-15 54.2 10.7 3.7e-06 26.5 0.2 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 AMD19593.1 - 0.00032 18.9 0.5 0.00081 17.6 0.1 1.7 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PQQ_3 PF13570.1 AMD19593.1 - 0.0031 17.7 3.5 0.031 14.5 0.0 3.7 4 1 0 4 4 4 1 PQQ-like domain PQQ PF01011.16 AMD19593.1 - 0.0058 16.1 0.1 0.019 14.4 0.1 2.0 1 0 0 1 1 1 1 PQQ enzyme repeat PQQ_2 PF13360.1 AMD19593.1 - 0.023 14.1 0.2 0.07 12.5 0.1 1.8 1 1 1 2 2 2 0 PQQ-like domain NMT PF01233.14 AMD19594.1 - 2.3e-80 267.9 0.0 4.2e-80 267.0 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.10 AMD19594.1 - 3.7e-75 251.5 0.5 1.3e-74 249.6 0.3 1.8 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.1 AMD19594.1 - 0.00018 21.3 0.0 0.002 17.9 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 AMD19594.1 - 0.0032 17.6 0.0 0.023 14.8 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF1576 PF07613.6 AMD19594.1 - 0.11 12.0 0.0 17 4.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1576) Vfa1 PF08432.5 AMD19595.1 - 0.0042 17.1 1.4 0.0079 16.2 1.0 1.4 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 DUF3492 PF11997.3 AMD19595.1 - 0.036 13.6 0.3 0.054 13.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Apt1 PF10351.4 AMD19595.1 - 0.11 11.2 6.8 0.16 10.7 4.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PRELI PF04707.9 AMD19596.1 - 3e-41 140.6 0.0 3.5e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family Glu_synthase PF01645.12 AMD19597.1 - 3.4e-156 519.8 0.1 7.4e-156 518.6 0.0 1.6 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.16 AMD19597.1 - 1.7e-134 448.0 0.0 2.9e-134 447.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 AMD19597.1 - 4.5e-117 390.4 0.1 3.9e-116 387.3 0.0 2.4 3 0 0 3 3 3 1 Glutamate synthase central domain GXGXG PF01493.14 AMD19597.1 - 8.8e-59 197.9 0.8 1.9e-58 196.8 0.5 1.5 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 AMD19597.1 - 2.5e-23 81.8 0.1 4.6e-23 80.9 0.1 1.4 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 AMD19597.1 - 3.6e-14 53.1 0.0 9.4e-14 51.7 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 AMD19597.1 - 4.7e-09 36.1 0.0 1.2e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 AMD19597.1 - 1e-08 35.5 0.1 0.0018 18.3 0.0 3.0 2 1 1 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 AMD19597.1 - 2e-07 31.2 0.1 2.2e-05 24.7 0.0 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 AMD19597.1 - 1e-05 24.8 0.0 1.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.9 AMD19597.1 - 1.2e-05 23.9 1.3 3.1e-05 22.6 0.0 2.2 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.19 AMD19597.1 - 1.5e-05 24.0 0.1 4.7e-05 22.4 0.1 1.9 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AMD19597.1 - 0.00012 21.0 0.0 0.00025 20.0 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_Gly3P_dh_N PF01210.18 AMD19597.1 - 0.0003 20.5 0.0 0.00064 19.4 0.0 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_oxidored PF12831.2 AMD19597.1 - 0.00068 18.8 0.0 0.0014 17.8 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 AMD19597.1 - 0.0013 17.8 0.0 0.0048 16.0 0.0 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 AMD19597.1 - 0.0036 16.3 0.0 0.007 15.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 AMD19597.1 - 0.0087 14.9 2.4 0.037 12.8 0.0 2.8 3 0 0 3 3 3 1 Glucose inhibited division protein A GATase_6 PF13522.1 AMD19597.1 - 0.019 14.9 0.0 0.067 13.1 0.0 1.9 1 0 0 1 1 1 0 Glutamine amidotransferase domain NAD_binding_7 PF13241.1 AMD19597.1 - 0.022 14.9 0.6 2.4 8.4 0.0 2.8 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_9 PF13454.1 AMD19597.1 - 0.034 13.9 0.0 0.2 11.3 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.14 AMD19597.1 - 0.071 12.2 0.0 3.6 6.7 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMN_dh PF01070.13 AMD19597.1 - 0.2 10.4 2.7 0.34 9.6 0.6 2.3 3 0 0 3 3 3 0 FMN-dependent dehydrogenase DUF3602 PF12223.3 AMD19598.1 - 4.6e-20 71.7 12.7 6.2e-13 48.9 0.1 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) eIF3_subunit PF08597.5 AMD19599.1 - 1.1e-56 192.1 24.6 1.1e-55 188.8 17.0 1.9 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit Peroxin-13_N PF04088.8 AMD19600.1 - 2.4e-52 177.0 1.5 3.4e-52 176.5 1.1 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.23 AMD19600.1 - 1.9e-09 36.7 0.0 3.4e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 AMD19600.1 - 3e-08 33.1 0.0 4.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 AMD19600.1 - 4e-07 29.4 0.0 7.5e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.6 AMD19600.1 - 0.00023 21.3 0.0 0.00045 20.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain MMR1 PF08505.5 AMD19601.1 - 7.7e-11 42.4 10.3 7.7e-11 42.4 7.2 2.7 2 1 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein DUF4482 PF14818.1 AMD19601.1 - 0.011 16.3 2.5 0.011 16.3 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) bZIP_1 PF00170.16 AMD19601.1 - 0.69 9.9 9.2 0.61 10.0 0.4 2.9 1 1 0 2 2 2 0 bZIP transcription factor Viral_P18 PF04521.8 AMD19601.1 - 7.5 6.0 9.9 4.2 6.8 1.9 2.4 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein PALP PF00291.20 AMD19602.1 - 1.7e-70 237.6 0.1 2.2e-70 237.3 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 AMD19602.1 - 4.7e-42 141.4 0.0 1.8e-24 85.1 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase tRNA-synt_2b PF00587.20 AMD19603.1 - 8.9e-29 100.2 0.0 2.2e-28 99.0 0.1 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AMD19603.1 - 0.038 13.9 0.0 0.093 12.6 0.0 1.6 1 0 0 1 1 1 0 Anticodon binding domain Sec61_beta PF03911.11 AMD19604.1 - 4e-19 68.1 1.3 4.9e-19 67.8 0.9 1.1 1 0 0 1 1 1 1 Sec61beta family Cas_Csx9 PF09658.5 AMD19604.1 - 0.0037 16.1 0.0 0.0041 15.9 0.0 1.0 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Csx9) PsbH PF00737.15 AMD19604.1 - 0.19 11.2 0.8 0.29 10.7 0.5 1.2 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein DUF2638 PF10937.3 AMD19605.1 - 2.1e-25 89.9 0.0 2.5e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2638) PDEase_II PF02112.10 AMD19606.1 - 3.3e-64 216.9 0.4 1.3e-61 208.4 1.0 2.1 1 1 1 2 2 2 2 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.2 AMD19606.1 - 1.1e-08 34.8 0.1 1.5e-08 34.4 0.1 1.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 AMD19606.1 - 0.026 14.2 1.7 0.061 12.9 1.2 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Proteasome PF00227.21 AMD19607.1 - 3.2e-25 88.5 0.1 3.8e-25 88.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Adap_comp_sub PF00928.16 AMD19608.1 - 3.9e-13 49.1 0.6 5.6e-13 48.5 0.4 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 AMD19608.1 - 8e-06 25.6 0.5 1.9e-05 24.3 0.4 1.7 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribonuc_red_lgC PF02867.10 AMD19610.1 - 5.8e-205 681.9 0.0 7e-205 681.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 AMD19610.1 - 2.4e-24 84.9 0.0 5.5e-24 83.7 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 AMD19610.1 - 0.05 14.0 0.0 0.14 12.5 0.0 1.9 1 0 0 1 1 1 0 ATP cone domain APG6 PF04111.7 AMD19611.1 - 5.1e-101 337.8 13.0 6.6e-101 337.4 9.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 NHR2 PF08788.6 AMD19611.1 - 0.01 15.3 0.0 0.026 13.9 0.0 1.7 1 0 0 1 1 1 1 NHR2 domain like Rpr2 PF04032.11 AMD19611.1 - 0.088 12.6 0.1 0.088 12.6 0.1 2.1 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain V_ATPase_I PF01496.14 AMD19611.1 - 0.4 8.4 9.8 0.68 7.7 6.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1465 PF07323.7 AMD19611.1 - 0.5 9.9 5.1 1.2 8.6 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) IFT46_B_C PF12317.3 AMD19611.1 - 0.87 8.9 6.9 2.5 7.3 1.8 2.3 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal Vfa1 PF08432.5 AMD19611.1 - 2.2 8.2 18.0 0.91 9.5 10.5 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Vac_Fusion PF02346.11 AMD19611.1 - 2.2 7.7 6.9 3.8 7.0 0.4 2.8 2 0 0 2 2 2 0 Chordopoxvirus fusion protein RVT_connect PF06815.8 AMD19611.1 - 3.6 7.5 6.0 26 4.7 0.2 3.3 3 0 0 3 3 3 0 Reverse transcriptase connection domain MMR_HSR1 PF01926.18 AMD19612.1 - 8e-11 41.9 0.0 2.8e-10 40.1 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 AMD19612.1 - 5.6e-06 25.6 0.0 1.2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 AMD19612.1 - 0.0015 18.3 0.0 0.0057 16.4 0.0 1.8 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 AMD19612.1 - 0.0043 16.4 0.0 0.23 10.8 0.0 2.5 1 1 2 3 3 3 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 AMD19612.1 - 0.009 15.2 0.2 0.039 13.2 0.1 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Miro PF08477.8 AMD19612.1 - 0.018 15.5 0.0 0.065 13.7 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein PhnJ PF06007.6 AMD19612.1 - 0.02 13.6 0.0 0.046 12.4 0.0 1.5 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnJ AAA_16 PF13191.1 AMD19612.1 - 0.15 11.9 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Noc2 PF03715.8 AMD19613.1 - 9.3e-124 412.1 4.6 9.3e-124 412.1 3.2 3.1 3 0 0 3 3 3 2 Noc2p family Mei5 PF10376.4 AMD19614.1 - 1.3e-34 119.7 15.0 1.5e-34 119.4 10.4 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein Exonuc_VII_S PF02609.11 AMD19614.1 - 0.02 14.6 1.0 0.02 14.6 0.7 3.1 3 1 0 3 3 3 0 Exonuclease VII small subunit HTH_Tnp_Tc3_1 PF11427.3 AMD19614.1 - 0.16 11.5 0.5 12 5.6 0.1 2.6 2 0 0 2 2 2 0 Tc3 transposase DUF3440 PF11922.3 AMD19614.1 - 0.25 10.8 7.4 0.044 13.3 1.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3440) HTH_38 PF13936.1 AMD19614.1 - 3.3 7.3 6.3 0.25 10.9 0.2 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain DDHD PF02862.12 AMD19614.1 - 8.8 6.0 8.0 31 4.2 5.5 1.7 1 1 0 1 1 1 0 DDHD domain RNA_pol_Rpb2_6 PF00562.23 AMD19615.1 - 1.1e-121 406.2 0.2 1.1e-121 406.2 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 AMD19615.1 - 7.3e-58 194.8 1.5 1.2e-57 194.1 1.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 AMD19615.1 - 2.5e-41 141.2 4.6 7.7e-41 139.5 3.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 AMD19615.1 - 1.9e-29 101.7 0.1 6.7e-29 99.9 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 AMD19615.1 - 9e-28 95.8 0.4 3.5e-27 93.9 0.1 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 AMD19615.1 - 7.2e-19 67.3 0.0 1.7e-18 66.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 AMD19615.1 - 8.1e-12 44.9 0.1 3.1e-11 43.0 0.1 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Tfb2 PF03849.9 AMD19616.1 - 2.2e-154 513.5 0.3 2.2e-154 513.5 0.2 1.4 2 0 0 2 2 2 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 AMD19616.1 - 1.5e-06 27.9 0.0 3.6e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AMD19617.1 - 1.6e-46 157.9 0.0 3.4e-45 153.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19617.1 - 5.9e-27 93.3 0.1 1.3e-26 92.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD19617.1 - 0.0062 16.3 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 AMD19617.1 - 0.087 12.7 0.0 0.23 11.4 0.0 1.7 2 0 0 2 2 2 0 Helicase C-terminal domain CMS1 PF14617.1 AMD19617.1 - 0.12 11.4 0.0 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Mit_ribos_Mrp51 PF11709.3 AMD19618.1 - 1.3e-73 248.0 0.1 1.8e-73 247.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit IGPD PF00475.13 AMD19619.1 - 5.9e-61 204.5 0.6 1.5e-60 203.2 0.3 1.6 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase SpoU_methylase PF00588.14 AMD19620.1 - 8.4e-29 100.2 0.0 2.1e-28 98.9 0.0 1.7 2 0 0 2 2 2 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 AMD19620.1 - 5.7e-15 55.2 0.0 2e-14 53.4 0.0 2.0 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding NUDIX PF00293.23 AMD19621.1 - 1.2e-28 99.4 0.0 1.7e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF342 PF03961.8 AMD19622.1 - 2.5e-05 22.8 14.4 2.5e-05 22.8 10.0 3.9 2 1 2 4 4 4 1 Protein of unknown function (DUF342) Baculo_PEP_C PF04513.7 AMD19622.1 - 0.048 13.4 18.9 1.2 9.0 2.5 4.7 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mitofilin PF09731.4 AMD19622.1 - 0.16 10.6 52.3 0.017 13.8 3.7 3.4 2 1 1 3 3 3 0 Mitochondrial inner membrane protein DELLA PF12041.3 AMD19622.1 - 0.45 10.2 7.7 1.7 8.3 0.1 3.3 2 1 1 3 3 3 0 Transcriptional regulator DELLA protein N terminal Reo_sigmaC PF04582.7 AMD19622.1 - 1.9 7.6 14.0 1.6 7.8 2.1 2.9 2 1 1 3 3 3 0 Reovirus sigma C capsid protein YojJ PF10372.4 AMD19622.1 - 2.9 7.8 11.1 0.08 12.8 1.4 3.2 3 1 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus DUF1409 PF07197.7 AMD19622.1 - 3.6 7.7 16.6 1.1 9.3 0.4 5.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1409) IclR PF01614.13 AMD19622.1 - 4 7.1 7.5 3.8 7.2 0.2 2.8 2 0 0 2 2 2 0 Bacterial transcriptional regulator Peptidase_C14 PF00656.17 AMD19623.1 - 2.7e-69 233.6 0.0 4.2e-69 232.9 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Hist_deacetyl PF00850.14 AMD19624.1 - 5e-62 209.9 0.1 8.2e-62 209.2 0.1 1.4 1 0 0 1 1 1 1 Histone deacetylase domain Radical_SAM PF04055.16 AMD19625.1 - 8.5e-15 55.3 0.0 1.5e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Ivy PF08816.6 AMD19625.1 - 0.072 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Inhibitor of vertebrate lysozyme (Ivy) RhoGAP PF00620.22 AMD19626.1 - 1.8e-34 118.5 0.0 4.4e-34 117.2 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.24 AMD19626.1 - 7.9e-08 32.4 0.2 2.7e-07 30.7 0.1 2.0 1 0 0 1 1 1 1 PH domain PX PF00787.19 AMD19626.1 - 9.7e-06 25.3 0.0 2.6e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 PX domain Spc42p PF11544.3 AMD19626.1 - 0.018 14.9 0.1 0.051 13.5 0.1 1.8 1 0 0 1 1 1 0 Spindle pole body component Spc42p DUF1708 PF08101.6 AMD19626.1 - 0.021 13.6 0.0 0.036 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) Kinetocho_Slk19 PF12709.2 AMD19627.1 - 2.4e-31 107.6 16.2 2.4e-31 107.6 11.2 9.0 4 1 4 9 9 9 3 Central kinetochore-associated DUF869 PF05911.6 AMD19627.1 - 0.00016 20.0 39.3 0.00016 20.0 27.2 2.8 1 1 1 2 2 2 1 Plant protein of unknown function (DUF869) ADIP PF11559.3 AMD19627.1 - 0.0013 18.6 96.3 0.0015 18.4 9.6 7.6 2 2 5 7 7 7 3 Afadin- and alpha -actinin-Binding ATG16 PF08614.6 AMD19627.1 - 0.0025 17.6 23.4 0.0025 17.6 16.2 6.4 1 1 5 6 6 6 2 Autophagy protein 16 (ATG16) FlxA PF14282.1 AMD19627.1 - 0.012 15.5 5.9 0.012 15.5 4.1 8.0 1 1 5 7 7 6 0 FlxA-like protein IncA PF04156.9 AMD19627.1 - 0.065 12.8 113.3 0.72 9.4 12.4 6.0 1 1 4 5 5 5 0 IncA protein CENP-F_leu_zip PF10473.4 AMD19627.1 - 0.11 12.3 113.3 0.039 13.8 16.1 6.2 2 2 3 5 5 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 AMD19627.1 - 0.33 10.0 38.1 0.39 9.8 1.1 5.4 1 1 5 6 6 6 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 AMD19627.1 - 0.96 7.8 88.5 0.0043 15.5 16.6 4.3 2 1 2 4 4 4 0 AAA domain Filament PF00038.16 AMD19627.1 - 0.97 8.8 97.9 0.37 10.1 11.3 5.6 1 1 4 5 5 5 0 Intermediate filament protein MscS_porin PF12795.2 AMD19627.1 - 3 7.1 100.6 0.036 13.3 13.5 5.4 1 1 3 4 4 4 0 Mechanosensitive ion channel porin domain MAD PF05557.8 AMD19627.1 - 5.3 5.0 100.0 0.14 10.2 14.4 3.9 1 1 2 4 4 4 0 Mitotic checkpoint protein TFIIA PF03153.8 AMD19628.1 - 8.4e-58 197.0 21.4 1.4e-32 114.0 10.3 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Jun PF03957.8 AMD19628.1 - 1 9.0 4.0 5.7 6.5 2.8 1.9 1 1 0 1 1 1 0 Jun-like transcription factor PEX11 PF05648.9 AMD19629.1 - 2.9e-07 30.0 4.7 9.9e-07 28.2 0.5 2.5 1 1 1 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) SKG6 PF08693.5 AMD19630.1 - 7.8e-08 31.5 1.1 1.1e-07 30.9 0.8 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Alpha_GJ PF03229.8 AMD19630.1 - 0.0059 16.9 0.2 0.0081 16.4 0.2 1.2 1 0 0 1 1 1 1 Alphavirus glycoprotein J PMP1_2 PF08114.6 AMD19630.1 - 0.014 14.8 0.2 0.028 13.9 0.1 1.4 1 0 0 1 1 1 0 ATPase proteolipid family Arginase PF00491.16 AMD19631.1 - 4.3e-74 249.3 0.0 5e-74 249.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family RRM_6 PF14259.1 AMD19632.1 - 0.068 13.1 0.1 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) GDPD PF03009.12 AMD19633.1 - 4.8e-76 255.6 0.0 9e-76 254.7 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SPX PF03105.14 AMD19633.1 - 6.3e-37 127.8 8.0 6.3e-37 127.8 5.6 2.3 2 0 0 2 2 2 1 SPX domain Ank_2 PF12796.2 AMD19633.1 - 6.3e-26 90.5 0.1 9.8e-16 57.8 0.0 4.5 4 1 1 5 5 5 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 AMD19633.1 - 2.6e-23 81.9 0.0 7.2e-07 29.5 0.0 4.9 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 AMD19633.1 - 3.9e-22 76.8 0.6 0.006 16.3 0.0 7.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.1 AMD19633.1 - 1.6e-19 68.0 0.6 0.0006 19.8 0.0 7.7 7 1 1 8 8 8 5 Ankyrin repeat Ank_5 PF13857.1 AMD19633.1 - 8.1e-15 54.5 0.0 0.053 13.7 0.0 5.9 3 1 3 6 6 6 5 Ankyrin repeats (many copies) UBN2_2 PF14227.1 AMD19633.1 - 0.11 12.1 6.6 0.45 10.0 0.0 3.1 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type TLC PF03219.9 AMD19633.1 - 0.22 9.9 0.0 0.35 9.2 0.0 1.2 1 0 0 1 1 1 0 TLC ATP/ADP transporter ABC1 PF03109.11 AMD19634.1 - 3.1e-21 75.5 0.0 6.7e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Arf PF00025.16 AMD19635.1 - 1.7e-76 255.3 0.1 2e-76 255.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 AMD19635.1 - 3.6e-11 42.6 0.0 4.2e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 AMD19635.1 - 8.3e-11 41.4 0.0 9.4e-11 41.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 AMD19635.1 - 1.5e-10 40.6 0.0 1.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 AMD19635.1 - 1.4e-09 37.1 0.5 2.9e-06 26.2 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 AMD19635.1 - 1.6e-09 38.2 0.0 2.2e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 AMD19635.1 - 2.9e-05 23.5 0.2 0.00045 19.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD19635.1 - 0.00014 21.7 0.0 0.00021 21.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 AMD19635.1 - 0.00022 21.5 0.2 0.00092 19.5 0.2 1.8 1 1 0 1 1 1 1 ABC transporter ArgK PF03308.11 AMD19635.1 - 0.0015 17.3 0.7 0.16 10.7 0.2 2.9 2 1 0 2 2 2 1 ArgK protein cobW PF02492.14 AMD19635.1 - 0.087 12.2 0.5 4.4 6.6 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.17 AMD19635.1 - 0.14 11.5 0.4 0.54 9.6 0.1 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PDH PF02153.12 AMD19637.1 - 2.4e-08 33.1 0.0 3.4e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.10 AMD19637.1 - 2.7e-06 27.3 0.0 5.7e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 AMD19637.1 - 5.4e-06 25.9 0.0 1.3e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 AMD19637.1 - 2.7e-05 24.5 0.0 6.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 AMD19637.1 - 3.2e-05 23.1 0.0 7.3e-05 21.9 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 AMD19637.1 - 0.0021 18.0 0.0 0.0076 16.2 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain 3HCDH_N PF02737.13 AMD19637.1 - 0.0033 17.1 0.0 0.0071 16.0 0.0 1.7 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 AMD19637.1 - 0.0096 15.3 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain UDPG_MGDP_dh_N PF03721.9 AMD19637.1 - 0.021 14.1 0.0 0.043 13.1 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Rossmann-like PF10727.4 AMD19637.1 - 0.15 11.8 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain Ureidogly_hydro PF04115.7 AMD19638.1 - 8.3e-26 90.2 0.0 1.6e-25 89.3 0.0 1.5 1 1 0 1 1 1 1 Ureidoglycolate hydrolase Rpp20 PF12328.3 AMD19640.1 - 7.2e-28 97.0 8.8 1.9e-26 92.4 6.1 2.0 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 AMD19640.1 - 7.4e-17 60.7 0.3 1.2e-16 59.9 0.2 1.4 1 0 0 1 1 1 1 Alba BAAT_C PF08840.6 AMD19640.1 - 0.048 13.3 0.0 0.059 13.0 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Cap_synth_GfcB PF11102.3 AMD19640.1 - 0.11 12.0 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 Group 4 capsule polysaccharide formation lipoprotein gfcB Cmyb_C PF09316.5 AMD19640.1 - 0.27 10.8 1.7 7.6 6.1 0.1 2.0 2 0 0 2 2 2 0 C-myb, C-terminal Pex24p PF06398.6 AMD19641.1 - 7.4e-34 117.0 20.0 8.8e-34 116.8 13.9 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF1070 PF06376.7 AMD19641.1 - 0.03 14.1 0.9 0.068 13.0 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1070) Oxidored-like PF09791.4 AMD19642.1 - 3.6e-23 80.7 1.7 7.1e-23 79.7 1.2 1.5 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal HSP70 PF00012.15 AMD19643.1 - 4.2e-180 599.6 4.5 4.2e-180 599.6 3.1 2.1 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 AMD19643.1 - 4.3e-10 38.6 0.2 9e-10 37.6 0.1 1.4 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.1 AMD19643.1 - 4.5e-06 26.4 2.5 0.00018 21.3 0.1 3.8 2 2 0 2 2 2 1 Cell division protein FtsA NPL4 PF05021.10 AMD19644.1 - 3.9e-121 403.9 0.0 5e-121 403.5 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 AMD19644.1 - 3.8e-70 234.2 0.6 6.5e-70 233.4 0.4 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 AMD19644.1 - 1.3e-07 31.7 0.0 3.9e-07 30.2 0.0 1.9 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.4 AMD19645.1 - 8.3e-76 253.6 4.8 9.3e-76 253.4 3.3 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 Methuselah_N PF06652.7 AMD19645.1 - 0.043 13.3 0.1 0.11 12.0 0.0 1.6 1 1 0 2 2 2 0 Methuselah N-terminus GYF PF02213.11 AMD19646.1 - 1.6e-16 59.6 1.5 5e-16 58.0 1.0 1.9 1 0 0 1 1 1 1 GYF domain UMP1 PF05348.6 AMD19647.1 - 9.5e-30 103.2 0.0 1.1e-29 103.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 IIGP PF05049.8 AMD19647.1 - 0.11 11.3 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) WD40 PF00400.27 AMD19648.1 - 4.2e-32 108.8 12.7 2.2e-08 33.6 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 AMD19648.1 - 3e-05 23.8 0.1 0.0022 17.7 0.0 2.7 2 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 AMD19648.1 - 6.9e-05 21.1 0.0 0.055 11.6 0.0 2.5 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.9 AMD19648.1 - 0.00099 18.0 0.0 0.0042 15.9 0.0 1.7 2 0 0 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.11 AMD19648.1 - 0.0054 15.0 0.0 0.019 13.2 0.0 1.9 1 1 0 1 1 1 1 Cytochrome D1 heme domain PQQ_3 PF13570.1 AMD19648.1 - 0.057 13.7 0.0 1.7 9.0 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain DPPIV_N PF00930.16 AMD19648.1 - 0.13 10.7 0.2 0.96 7.9 0.1 2.2 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region tRNA-synt_2 PF00152.15 AMD19649.1 - 1.7e-114 382.0 0.0 2.4e-114 381.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AMD19649.1 - 9.3e-09 35.0 0.1 1.8e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.20 AMD19649.1 - 0.002 17.7 0.1 0.14 11.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) Pantoate_transf PF02548.10 AMD19650.1 - 4.2e-98 327.6 0.1 4.9e-98 327.4 0.1 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 AMD19650.1 - 6.9e-06 25.4 0.1 9.8e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Lactamase_B_2 PF12706.2 AMD19651.1 - 5.1e-32 111.0 0.3 7.4e-32 110.4 0.2 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 AMD19651.1 - 1.5e-10 41.0 0.0 2.7e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TrmE_N PF10396.4 AMD19653.1 - 1.9e-32 111.5 0.0 6.4e-32 109.9 0.0 1.9 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.18 AMD19653.1 - 4e-22 78.3 0.2 9.1e-22 77.1 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTPase_Cys_C PF12631.2 AMD19653.1 - 5.7e-15 55.4 0.2 1.7e-13 50.7 0.0 2.9 3 0 0 3 3 2 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE FeoB_N PF02421.13 AMD19653.1 - 1.8e-11 43.5 0.1 3.5e-11 42.6 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 AMD19653.1 - 4.6e-08 32.7 0.1 5e-07 29.3 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 AMD19653.1 - 1.5e-07 30.8 1.1 1.2e-06 27.9 0.7 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.18 AMD19653.1 - 3.1e-07 30.3 0.8 0.0063 16.3 0.1 2.4 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 AMD19653.1 - 1.8e-06 28.4 0.2 1.8e-05 25.2 0.1 2.4 1 1 0 1 1 1 1 Miro-like protein Ras PF00071.17 AMD19653.1 - 0.00019 20.8 0.6 0.0011 18.3 0.0 2.3 2 1 0 2 2 2 1 Ras family Septin PF00735.13 AMD19653.1 - 0.00037 19.6 1.3 0.0026 16.8 0.6 2.1 1 1 0 2 2 2 1 Septin cobW PF02492.14 AMD19653.1 - 0.017 14.6 2.6 0.56 9.6 0.6 2.4 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.1 AMD19653.1 - 0.031 14.3 0.3 0.15 12.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 AMD19653.1 - 0.048 12.8 0.1 0.13 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ArgK PF03308.11 AMD19653.1 - 0.072 11.8 1.5 7.5 5.2 0.0 2.7 1 1 1 2 2 2 0 ArgK protein Gon7 PF08738.5 AMD19654.1 - 0.019 14.9 0.1 0.03 14.3 0.1 1.4 1 0 0 1 1 1 0 Gon7 family BLOC1_2 PF10046.4 AMD19654.1 - 0.075 13.1 3.5 0.23 11.5 2.2 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HTH_Tnp_Tc5 PF03221.11 AMD19654.1 - 0.086 12.6 0.3 0.3 10.9 0.0 2.0 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain DUF848 PF05852.6 AMD19654.1 - 0.3 10.9 4.1 0.43 10.4 2.6 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Rho_Binding PF08912.6 AMD19654.1 - 7.5 6.9 8.4 6.3 7.1 2.0 2.7 1 1 2 3 3 3 0 Rho Binding DUF2347 PF09804.4 AMD19655.1 - 5.5e-73 245.6 0.0 7.4e-73 245.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.1 AMD19655.1 - 3.8e-14 53.1 5.4 2e-07 31.2 1.9 3.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4484) SPA PF08616.5 AMD19655.1 - 0.016 14.9 0.0 0.043 13.5 0.0 1.7 1 0 0 1 1 1 0 Stabilization of polarity axis TPR_17 PF13431.1 AMD19655.1 - 5.4 7.4 5.3 2.7 8.3 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_76 PF03663.9 AMD19656.1 - 5.7e-143 476.7 11.0 6.7e-143 476.5 7.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_76 PF03663.9 AMD19657.1 - 1.4e-144 482.0 14.6 1.7e-144 481.7 10.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 UQ_con PF00179.21 AMD19658.1 - 1.4e-48 163.9 0.0 1.5e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 AMD19658.1 - 0.11 12.4 1.9 0.26 11.2 0.5 2.0 1 1 0 2 2 2 0 RWD domain Copper-fist PF00649.13 AMD19659.1 - 8.8e-22 76.0 3.8 8.8e-22 76.0 2.6 2.3 2 0 0 2 2 2 1 Copper fist DNA binding domain Amino_oxidase PF01593.19 AMD19660.1 - 3.8e-52 177.8 0.0 2.7e-51 175.0 0.0 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 AMD19660.1 - 6.9e-10 38.8 0.0 1.4e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 AMD19660.1 - 7.9e-08 32.5 0.2 3.4e-05 23.9 0.0 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 AMD19660.1 - 3.7e-05 22.7 0.9 0.00056 18.8 0.6 2.0 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.14 AMD19660.1 - 0.0002 20.5 0.5 0.00034 19.7 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.1 AMD19660.1 - 0.00032 20.4 2.2 0.25 11.0 0.1 2.8 2 1 1 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.19 AMD19660.1 - 0.00068 18.6 0.1 0.013 14.3 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 AMD19660.1 - 0.0087 15.9 0.4 0.018 14.8 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 AMD19660.1 - 0.011 14.8 0.1 0.02 14.0 0.1 1.3 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.9 AMD19660.1 - 0.026 13.0 1.0 0.044 12.2 0.3 1.6 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.7 AMD19660.1 - 0.039 12.8 0.3 0.27 10.0 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.22 AMD19660.1 - 0.091 13.1 2.3 0.41 11.0 0.5 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 AMD19660.1 - 0.14 12.2 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 AMD19660.1 - 0.14 12.1 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain DNA_primase_lrg PF04104.9 AMD19661.1 - 3.5e-78 262.4 0.1 4.8e-78 262.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit KilA-N PF04383.8 AMD19662.1 - 0.00077 19.0 0.0 0.00077 19.0 0.0 3.4 2 2 0 2 2 2 1 KilA-N domain Spc42p PF11544.3 AMD19663.1 - 2e-24 85.3 2.3 2e-24 85.3 1.6 3.8 4 0 0 4 4 4 1 Spindle pole body component Spc42p PhoU PF01895.14 AMD19663.1 - 0.0091 16.4 2.6 18 5.8 0.0 3.3 3 0 0 3 3 3 2 PhoU domain Occludin_ELL PF07303.8 AMD19663.1 - 0.78 10.5 11.6 0.99 10.1 1.8 3.2 2 1 1 3 3 3 0 Occludin homology domain DivIVA PF05103.8 AMD19663.1 - 1.9 8.5 19.1 1.5 8.8 1.3 2.8 1 1 1 2 2 2 0 DivIVA protein BUD22 PF09073.5 AMD19664.1 - 1.1e-83 281.6 33.9 1.5e-83 281.2 23.5 1.1 1 0 0 1 1 1 1 BUD22 CTP_transf_1 PF01148.15 AMD19665.1 - 7.1e-07 29.1 2.5 7.1e-07 29.1 1.7 4.4 2 2 2 4 4 4 2 Cytidylyltransferase family FTR1 PF03239.9 AMD19665.1 - 8.2e-05 21.7 3.5 0.0002 20.4 2.4 1.6 1 0 0 1 1 1 1 Iron permease FTR1 family CLU PF13236.1 AMD19666.1 - 2.7e-65 219.9 0.1 5e-65 219.0 0.1 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 AMD19666.1 - 1.5e-35 122.6 2.3 2.5e-24 86.0 0.0 3.7 3 0 0 3 3 3 2 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.1 AMD19666.1 - 7.6e-14 51.4 2.1 4e-08 33.0 0.5 4.2 2 1 4 6 6 5 4 Tetratricopeptide repeat CLU_N PF15044.1 AMD19666.1 - 7.2e-13 48.4 0.4 3.3e-12 46.3 0.3 2.3 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.1 AMD19666.1 - 2.2e-07 30.5 0.4 0.0019 18.0 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 AMD19666.1 - 0.0012 18.4 0.9 0.25 11.0 0.7 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 AMD19666.1 - 0.0028 17.2 3.7 0.0047 16.5 1.0 2.7 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 AMD19666.1 - 0.0051 16.6 5.3 0.023 14.5 0.5 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD19666.1 - 0.038 13.7 6.5 1.9 8.4 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 AMD19666.1 - 0.053 13.3 1.7 1.7 8.6 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 AMD19666.1 - 0.17 12.5 2.0 0.37 11.5 0.0 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat DnaJ PF00226.26 AMD19668.1 - 3e-21 74.8 0.9 5.9e-21 73.9 0.6 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 AMD19668.1 - 2.8e-16 59.1 0.1 1.9e-14 53.3 0.0 2.5 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 AMD19668.1 - 2.4e-09 37.0 19.1 6.1e-09 35.7 13.3 1.8 1 0 0 1 1 1 1 DnaJ central domain Pox_Ag35 PF03286.9 AMD19668.1 - 0.0094 15.4 14.7 0.018 14.6 10.2 1.4 1 0 0 1 1 1 1 Pox virus Ag35 surface protein Daxx PF03344.10 AMD19668.1 - 0.21 10.0 31.5 0.33 9.3 21.8 1.2 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 AMD19668.1 - 0.88 7.4 29.5 1.2 6.9 20.4 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.3 AMD19668.1 - 1.3 8.9 27.8 2.7 7.8 19.3 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.9 AMD19668.1 - 2.3 6.1 22.6 3.8 5.4 15.7 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.9 AMD19668.1 - 2.5 8.1 12.8 58 3.6 7.8 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 NPR3 PF03666.8 AMD19668.1 - 2.5 6.5 8.9 4.2 5.7 6.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pilt PF15453.1 AMD19668.1 - 5.3 6.6 12.5 11 5.6 8.6 1.4 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions Vfa1 PF08432.5 AMD19668.1 - 8 6.4 16.1 17 5.4 11.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ApoLp-III PF07464.6 AMD19669.1 - 0.00042 20.3 5.8 0.13 12.2 0.3 2.5 2 0 0 2 2 2 2 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.8 AMD19669.1 - 0.0028 18.0 17.8 0.034 14.5 0.4 4.7 3 1 1 5 5 5 1 Bacterial protein of unknown function (DUF883) MscS_porin PF12795.2 AMD19669.1 - 0.0046 16.2 0.2 0.0046 16.2 0.2 1.9 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain Apolipoprotein PF01442.13 AMD19669.1 - 0.0096 15.4 7.9 0.052 13.0 3.4 2.5 2 1 1 3 3 3 2 Apolipoprotein A1/A4/E domain DUF2508 PF10704.4 AMD19669.1 - 0.011 15.9 1.1 0.018 15.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Sec5 PF15469.1 AMD19669.1 - 0.014 15.1 3.4 0.15 11.7 2.3 2.2 1 1 0 1 1 1 0 Exocyst complex component Sec5 ApoO PF09769.4 AMD19669.1 - 0.029 14.0 1.5 0.44 10.2 0.0 2.8 3 0 0 3 3 3 0 Apolipoprotein O mit_SMPDase PF14724.1 AMD19669.1 - 0.2 9.4 0.5 0.38 8.4 0.3 1.4 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase Baculo_PEP_C PF04513.7 AMD19669.1 - 0.36 10.6 2.7 7.9 6.3 0.2 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DegS PF05384.6 AMD19669.1 - 0.4 9.8 4.2 0.64 9.2 0.3 2.5 2 0 0 2 2 2 0 Sensor protein DegS Prominin PF05478.6 AMD19669.1 - 0.74 7.2 5.4 4 4.8 0.1 2.0 1 1 1 2 2 2 0 Prominin Syntaxin-6_N PF09177.6 AMD19669.1 - 1.5 9.2 7.8 6.8 7.1 0.3 2.9 2 1 1 3 3 2 0 Syntaxin 6, N-terminal Syntaxin_2 PF14523.1 AMD19669.1 - 6.4 6.8 7.2 2.6 8.1 0.4 3.1 3 1 0 3 3 3 0 Syntaxin-like protein Laminin_II PF06009.7 AMD19669.1 - 7.1 6.3 9.3 1.4 8.6 1.4 2.7 3 0 0 3 3 3 0 Laminin Domain II DUF1752 PF08550.5 AMD19670.1 - 1.8e-12 46.6 0.2 3.7e-12 45.5 0.1 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) PBP1_TM PF14812.1 AMD19670.1 - 0.47 10.7 3.5 0.62 10.4 0.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Brix PF04427.13 AMD19671.1 - 4.5e-46 156.9 0.2 5.8e-46 156.5 0.1 1.1 1 0 0 1 1 1 1 Brix domain tRNA-synt_2 PF00152.15 AMD19672.1 - 1.5e-70 237.6 0.0 2e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 AMD19672.1 - 4.9e-08 32.4 0.1 3e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.20 AMD19672.1 - 3.4e-06 26.8 0.0 6.8e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.1 AMD19672.1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.20 AMD19672.1 - 0.013 15.1 0.0 3.7 7.1 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) RNase_HII PF01351.13 AMD19673.1 - 1.2e-61 207.8 0.0 1.6e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII 2-oxoacid_dh PF00198.18 AMD19674.1 - 1.1e-70 237.4 0.1 1.5e-70 237.0 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 AMD19674.1 - 6.8e-18 64.0 0.1 2.5e-17 62.2 0.1 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 AMD19674.1 - 3.1e-15 55.5 0.4 1.5e-14 53.3 0.1 2.2 2 0 0 2 2 2 1 e3 binding domain Tom7 PF08038.7 AMD19675.1 - 1.5e-19 69.1 0.1 2e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 TOM7 family Mito_carr PF00153.22 AMD19676.1 - 9.4e-56 185.5 7.5 7.1e-23 80.1 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L13 PF00572.13 AMD19677.1 - 5.8e-27 94.2 0.7 7.8e-27 93.8 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L13 Fork_head PF00250.13 AMD19679.1 - 1.2e-36 124.5 0.7 3.7e-36 123.0 0.1 2.1 2 0 0 2 2 2 1 Fork head domain FHA PF00498.21 AMD19679.1 - 1e-10 41.5 0.0 4.3e-10 39.5 0.0 2.2 1 0 0 1 1 1 1 FHA domain Fungal_trans PF04082.13 AMD19680.1 - 7.1e-27 93.9 0.1 1.1e-26 93.3 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD19680.1 - 2.2e-10 40.2 12.8 4.2e-10 39.3 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUN PF03856.8 AMD19682.1 - 2.7e-100 334.7 10.6 3.3e-100 334.5 7.4 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) adh_short PF00106.20 AMD19683.1 - 5.6e-28 97.9 0.1 7.1e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AMD19683.1 - 2.1e-19 70.2 0.0 3.1e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AMD19683.1 - 8.7e-10 38.5 0.0 1.3e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 AMD19683.1 - 4.6e-06 26.2 0.1 1.9e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 AMD19683.1 - 0.00026 21.0 0.1 0.00049 20.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding F420_oxidored PF03807.12 AMD19683.1 - 0.0056 17.0 0.1 0.01 16.2 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ADH_zinc_N PF00107.21 AMD19683.1 - 0.0094 15.5 0.0 0.33 10.4 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.3 AMD19683.1 - 0.02 14.6 0.4 0.038 13.7 0.3 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RmlD_sub_bind PF04321.12 AMD19683.1 - 0.02 13.7 0.1 0.035 12.9 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DFP PF04127.10 AMD19683.1 - 0.021 14.4 0.1 0.033 13.8 0.1 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Transket_pyr PF02779.19 AMD19684.1 - 1.9e-61 206.6 0.0 3.1e-61 205.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 AMD19684.1 - 1.3e-50 171.7 0.0 1.8e-50 171.3 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Ribosomal_L6 PF00347.18 AMD19685.1 - 6.9e-28 96.9 10.2 1.2e-13 51.3 2.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 LRR_4 PF12799.2 AMD19685.1 - 0.0067 16.0 0.2 0.55 9.9 0.0 2.4 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 AMD19685.1 - 0.13 12.3 0.1 15 6.0 0.0 2.7 2 0 0 2 2 2 0 Leucine Rich Repeat PC4 PF02229.11 AMD19685.1 - 0.15 11.2 1.0 0.44 9.8 0.0 2.2 3 0 0 3 3 3 0 Transcriptional Coactivator p15 (PC4) LRR_6 PF13516.1 AMD19685.1 - 0.21 11.7 0.7 3 8.1 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich repeat SNF2_N PF00176.18 AMD19686.1 - 6e-85 284.6 0.5 6e-85 284.6 0.3 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD19686.1 - 7.7e-20 70.5 0.1 2.2e-16 59.5 0.0 4.0 4 0 0 4 4 4 1 Helicase conserved C-terminal domain Bromodomain PF00439.20 AMD19686.1 - 2.4e-19 69.0 2.2 3.8e-19 68.3 0.2 2.4 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.1 AMD19686.1 - 1.7e-13 50.5 2.2 1.7e-13 50.5 1.5 4.6 6 0 0 6 6 6 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.8 AMD19686.1 - 0.00024 20.8 9.8 0.00024 20.8 6.8 3.4 3 0 0 3 3 3 1 HSA QLQ PF08880.6 AMD19686.1 - 0.037 13.4 0.3 0.15 11.4 0.0 2.2 2 0 0 2 2 2 0 QLQ Exonuc_VII_L PF02601.10 AMD19687.1 - 0.048 12.8 12.0 0.062 12.4 8.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Flu_PB1 PF00602.12 AMD19687.1 - 0.14 9.8 8.2 0.17 9.5 5.7 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 SieB PF14163.1 AMD19687.1 - 0.6 9.6 4.3 1.5 8.3 3.0 1.7 1 1 0 1 1 1 0 Superinfection exclusion protein B KIP1 PF07765.7 AMD19687.1 - 1.8 8.4 8.1 5.5 6.8 1.3 2.5 2 1 0 2 2 2 0 KIP1-like protein DUF262 PF03235.9 AMD19687.1 - 7.2 6.5 13.4 11 5.8 9.3 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF262 MMS19_N PF14500.1 AMD19688.1 - 2e-87 292.7 12.8 4.3e-87 291.7 0.1 4.0 4 1 1 5 5 5 2 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.3 AMD19688.1 - 4.2e-79 266.2 22.2 4.2e-79 266.2 15.4 2.8 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal HEAT PF02985.17 AMD19688.1 - 0.0006 19.6 0.1 1.1 9.5 0.0 5.1 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.1 AMD19688.1 - 0.00081 19.8 4.6 2 8.9 0.0 5.6 6 0 0 6 6 6 1 HEAT-like repeat HEAT_2 PF13646.1 AMD19688.1 - 0.0038 17.4 3.0 5.7 7.2 0.1 5.0 6 1 1 7 7 7 2 HEAT repeats DUF2435 PF10363.4 AMD19688.1 - 0.0087 15.9 7.8 1 9.2 0.1 4.5 4 0 0 4 4 4 1 Protein of unknown function (DUF2435) MOR2-PAG1_N PF14222.1 AMD19689.1 - 3.5e-179 597.0 11.2 3.5e-179 597.0 7.7 3.4 4 0 0 4 4 4 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 AMD19689.1 - 3e-94 315.6 4.2 1.7e-93 313.1 2.2 2.9 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 AMD19689.1 - 3.5e-24 84.5 17.2 6.3e-13 47.2 0.6 4.3 4 0 0 4 4 4 4 Cell morphogenesis central region ApoO PF09769.4 AMD19690.1 - 0.00016 21.4 0.8 0.0069 16.1 0.0 2.9 3 0 0 3 3 3 1 Apolipoprotein O Aa_trans PF01490.13 AMD19691.1 - 1.6e-87 293.6 33.7 1.9e-87 293.3 23.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DNA_pol_B PF00136.16 AMD19692.1 - 1.2e-114 383.6 5.9 2e-114 382.9 4.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 AMD19692.1 - 2.8e-65 219.2 0.9 6.1e-65 218.1 0.6 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 AMD19692.1 - 1.2e-40 139.4 0.0 2.4e-40 138.3 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.3 AMD19692.1 - 2.8e-17 62.2 8.5 2.8e-17 62.2 5.9 2.4 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal zinc_ribbon_5 PF13719.1 AMD19692.1 - 0.16 11.6 2.8 13 5.4 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AMD19692.1 - 0.27 10.9 2.9 15 5.4 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbon domain SNARE PF05739.14 AMD19693.1 - 2.2e-17 62.4 4.0 4.4e-17 61.5 2.8 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.1 AMD19693.1 - 1.2e-08 34.8 18.7 1.8e-07 31.0 0.7 3.8 2 2 1 3 3 3 2 Syntaxin-like protein Synaptobrevin PF00957.16 AMD19693.1 - 1e-05 25.0 1.4 1.9e-05 24.1 1.0 1.5 1 0 0 1 1 1 1 Synaptobrevin Baculo_PEP_C PF04513.7 AMD19693.1 - 0.016 15.0 3.5 0.016 15.0 2.4 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF912 PF06024.7 AMD19693.1 - 0.11 12.5 0.5 0.31 11.1 0.4 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) LPP PF04728.8 AMD19693.1 - 0.21 11.4 2.0 0.75 9.6 0.4 2.6 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Spc7 PF08317.6 AMD19693.1 - 0.24 10.0 12.4 0.095 11.3 4.8 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF3450 PF11932.3 AMD19693.1 - 0.33 10.1 10.2 0.64 9.2 7.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Cluap1 PF10234.4 AMD19693.1 - 0.53 9.4 8.7 1.2 8.2 6.0 1.7 1 1 0 1 1 1 0 Clusterin-associated protein-1 DUF1664 PF07889.7 AMD19693.1 - 1.1 9.1 5.4 0.59 9.9 1.9 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.7 AMD19693.1 - 9.3 6.5 9.7 26 5.1 4.1 3.2 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein bZIP_2 PF07716.10 AMD19694.1 - 0.00038 20.2 3.2 0.001 18.8 2.2 1.8 1 0 0 1 1 1 1 Basic region leucine zipper RGS PF00615.14 AMD19695.1 - 1.5e-14 54.0 0.3 2.5e-14 53.4 0.2 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain HMGL-like PF00682.14 AMD19696.1 - 1.6e-71 240.6 0.0 2.2e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 AMD19696.1 - 5.7e-25 87.6 1.2 1.3e-24 86.5 0.1 2.1 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain Syja_N PF02383.13 AMD19697.1 - 9.1e-95 317.0 0.2 1.5e-94 316.3 0.1 1.4 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 AMD19697.1 - 3.4e-25 89.3 0.0 6.2e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YEATS PF03366.11 AMD19699.1 - 1.2e-35 121.0 0.8 1.9e-35 120.4 0.6 1.3 1 0 0 1 1 1 1 YEATS family His_Phos_1 PF00300.17 AMD19700.1 - 7.8e-22 78.0 0.0 1.7e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TFIIIC_sub6 PF10419.4 AMD19700.1 - 4e-15 54.9 0.0 8.4e-15 53.9 0.0 1.6 1 0 0 1 1 1 1 TFIIIC subunit Maf PF02545.9 AMD19701.1 - 7.5e-45 152.4 0.0 9.2e-45 152.1 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein RRM_1 PF00076.17 AMD19702.1 - 4.1e-17 61.5 0.3 1.1e-16 60.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD19702.1 - 4.1e-12 45.9 0.0 7.2e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD19702.1 - 1.2e-09 37.9 0.1 2.6e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cyt-b5 PF00173.23 AMD19703.1 - 1.1e-25 89.1 0.2 1.4e-25 88.8 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cnd1 PF12717.2 AMD19704.1 - 0.0014 18.5 1.0 0.023 14.5 0.0 2.8 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 AMD19704.1 - 0.057 13.5 0.0 65 4.0 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat DEAD PF00270.24 AMD19705.1 - 9.6e-45 152.1 0.0 5.4e-44 149.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19705.1 - 3.4e-29 100.5 0.0 1.4e-28 98.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD19705.1 - 0.0008 19.2 0.0 0.0022 17.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 AMD19705.1 - 0.039 12.3 0.1 0.41 8.9 0.0 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1253) Helicase_C_2 PF13307.1 AMD19705.1 - 0.047 13.6 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain RNA_pol_L_2 PF13656.1 AMD19706.1 - 5.9e-31 105.7 0.0 8.2e-31 105.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 AMD19706.1 - 1.1e-12 46.8 0.0 1.5e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-H2C2_2 PF13465.1 AMD19707.1 - 7e-24 82.9 28.9 1e-09 38.2 0.7 4.5 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.21 AMD19707.1 - 1.3e-21 75.5 33.9 1e-06 28.6 0.3 4.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD19707.1 - 1e-15 56.8 26.8 0.00022 21.3 0.3 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-Di19 PF05605.7 AMD19707.1 - 0.013 15.6 10.7 0.049 13.7 0.4 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.5 AMD19707.1 - 0.13 12.2 14.7 3.4 7.6 0.1 4.2 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_6 PF13912.1 AMD19707.1 - 0.19 11.6 20.2 0.27 11.2 0.1 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.2 AMD19707.1 - 0.35 11.1 17.6 11 6.4 0.1 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD19707.1 - 0.49 10.6 19.8 1.7 8.8 0.4 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 AMD19707.1 - 1.1 9.4 16.8 14 5.8 2.2 3.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-CHCC PF10276.4 AMD19707.1 - 1.8 8.4 13.5 1.2 9.0 0.7 3.8 3 0 0 3 3 3 0 Zinc-finger domain TRAPP PF04051.11 AMD19708.1 - 4.1e-33 114.0 0.0 5.6e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SH3_9 PF14604.1 AMD19709.1 - 6.9e-24 83.1 0.2 6.6e-14 51.2 0.0 3.2 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.23 AMD19709.1 - 1.8e-22 78.4 0.1 1.4e-12 46.8 0.0 2.9 3 0 0 3 3 3 2 SH3 domain FCH PF00611.18 AMD19709.1 - 2.1e-22 79.0 0.1 2.1e-22 79.0 0.0 2.9 2 1 1 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.12 AMD19709.1 - 7.6e-13 47.7 0.4 6e-10 38.4 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 AMD19709.1 - 0.0025 17.9 2.0 0.13 12.4 0.2 2.6 2 0 0 2 2 2 1 Bacterial SH3 domain Matrilin_ccoil PF10393.4 AMD19709.1 - 0.12 11.7 0.7 0.51 9.7 0.1 2.4 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Baculo_PEP_C PF04513.7 AMD19709.1 - 4.1 7.2 6.2 2.4 7.9 0.3 2.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2417 PF10329.4 AMD19710.1 - 5.7e-50 169.8 6.3 8.1e-50 169.3 4.3 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_6 PF12697.2 AMD19710.1 - 8.2e-14 52.0 0.0 1.9e-13 50.8 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD19710.1 - 2.3e-09 37.1 0.0 6.7e-09 35.6 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AMD19710.1 - 0.0032 17.2 0.0 0.0093 15.7 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family FHA PF00498.21 AMD19711.1 - 1.9e-15 56.6 0.0 4.4e-15 55.5 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 AMD19711.1 - 4.9e-07 29.4 13.4 8.2e-07 28.7 9.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 AMD19711.1 - 1.1e-05 25.4 5.2 2.2e-05 24.4 3.6 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 AMD19711.1 - 0.0039 16.8 14.0 0.0067 16.0 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 AMD19711.1 - 0.0065 16.2 6.5 0.013 15.3 4.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 AMD19711.1 - 0.012 15.2 11.9 0.021 14.5 8.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Sec_GG PF07549.9 AMD19711.1 - 0.062 12.5 0.6 0.13 11.5 0.4 1.5 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-RING-like PF08746.6 AMD19711.1 - 0.078 12.9 9.0 0.17 11.8 6.2 1.6 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.1 AMD19711.1 - 0.2 11.7 15.2 0.35 10.9 10.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Malate_synthase PF01274.17 AMD19712.1 - 7.2e-205 680.9 0.0 8.8e-205 680.6 0.0 1.0 1 0 0 1 1 1 1 Malate synthase NMT1 PF09084.6 AMD19713.1 - 1.6e-16 60.5 0.1 2.8e-16 59.7 0.0 1.4 1 1 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 AMD19713.1 - 2e-07 30.6 0.0 2.7e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.15 AMD19713.1 - 9e-07 28.3 0.0 1.9e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysR_substrate PF03466.15 AMD19713.1 - 0.00039 19.5 0.0 0.00062 18.9 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain DCP2 PF05026.8 AMD19714.1 - 8.4e-33 112.1 0.5 2.5e-32 110.5 0.3 1.9 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 AMD19714.1 - 2.6e-12 46.5 0.0 6.1e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain DUF2392 PF10288.4 AMD19715.1 - 3e-31 107.9 0.1 9e-31 106.3 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) DUF1903 PF08991.5 AMD19716.1 - 8.8e-06 25.7 5.0 1.4e-05 25.1 3.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) CHCH PF06747.8 AMD19716.1 - 3.6e-05 23.5 7.0 5.3e-05 23.0 4.8 1.3 1 0 0 1 1 1 1 CHCH domain COX6B PF02297.12 AMD19716.1 - 0.13 12.2 7.1 0.25 11.3 4.9 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 AMD19716.1 - 0.3 11.1 3.9 0.56 10.2 2.7 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 TPR_11 PF13414.1 AMD19717.1 - 2.8e-40 135.7 24.4 1.2e-15 56.8 0.3 7.2 4 2 3 7 7 7 7 TPR repeat TPR_2 PF07719.12 AMD19717.1 - 1.8e-26 89.8 40.5 2.4e-05 23.9 0.0 11.7 10 2 2 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.23 AMD19717.1 - 7.4e-24 82.3 37.2 3.8e-06 26.2 0.0 10.8 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.1 AMD19717.1 - 2.2e-22 79.1 23.0 5e-06 27.0 0.8 7.5 5 2 3 8 8 7 5 Tetratricopeptide repeat TPR_14 PF13428.1 AMD19717.1 - 1.5e-18 65.6 12.8 0.013 16.1 0.2 9.9 5 2 5 10 10 10 4 Tetratricopeptide repeat TPR_17 PF13431.1 AMD19717.1 - 3.3e-18 64.3 11.5 9.4e-05 22.3 0.0 8.6 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 AMD19717.1 - 2.1e-17 63.1 20.6 0.00021 21.5 1.6 7.2 4 2 4 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.1 AMD19717.1 - 7.3e-17 61.0 22.5 0.001 18.9 0.5 8.2 4 3 4 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.1 AMD19717.1 - 2.2e-13 48.9 25.0 0.025 14.3 0.0 9.9 9 1 1 10 10 10 3 Tetratricopeptide repeat Apc3 PF12895.2 AMD19717.1 - 2.8e-07 30.5 22.2 0.0016 18.5 0.4 5.3 4 1 1 5 5 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 AMD19717.1 - 5.9e-06 26.0 5.2 0.094 12.5 0.0 5.1 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD19717.1 - 0.00042 19.8 16.7 0.63 9.9 0.2 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_20 PF14561.1 AMD19717.1 - 0.00076 19.5 10.8 0.31 11.1 1.2 5.0 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 AMD19717.1 - 0.005 17.2 24.4 13 6.4 0.0 9.4 10 0 0 10 10 9 0 Tetratricopeptide repeat DUF3808 PF10300.4 AMD19717.1 - 0.0085 14.7 13.3 0.6 8.6 0.0 4.7 3 1 2 5 5 5 2 Protein of unknown function (DUF3808) SPO22 PF08631.5 AMD19717.1 - 0.02 13.9 3.5 0.41 9.6 0.1 3.8 4 0 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like SpoIIIAH PF12685.2 AMD19717.1 - 0.046 13.2 4.0 0.12 11.8 2.7 1.7 1 0 0 1 1 1 0 SpoIIIAH-like protein PTS_IIA PF02255.11 AMD19717.1 - 0.13 12.1 6.5 0.49 10.2 0.1 4.3 4 1 0 4 4 4 0 PTS system, Lactose/Cellobiose specific IIA subunit TOM20_plant PF06552.7 AMD19717.1 - 0.17 11.4 17.6 6.8 6.2 0.1 5.7 3 1 3 6 6 6 0 Plant specific mitochondrial import receptor subunit TOM20 Exonuc_VII_S PF02609.11 AMD19717.1 - 3.7 7.3 14.2 0.34 10.6 0.2 4.9 5 0 0 5 5 5 0 Exonuclease VII small subunit Apc5 PF12862.2 AMD19717.1 - 5.1 7.0 7.6 7 6.5 0.3 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 Ribosomal_L35p PF01632.14 AMD19719.1 - 1.5e-07 31.2 2.9 2e-07 30.8 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 PDZ_1 PF12812.2 AMD19720.1 - 1.4e-52 175.4 0.2 2.7e-35 120.1 0.0 3.7 4 0 0 4 4 4 2 PDZ-like domain PDZ_2 PF13180.1 AMD19720.1 - 1.7e-13 50.2 3.3 6.5e-07 29.1 0.0 4.6 5 0 0 5 5 5 2 PDZ domain Trypsin_2 PF13365.1 AMD19720.1 - 2e-12 47.1 0.0 1.4e-11 44.3 0.0 2.2 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ PF00595.19 AMD19720.1 - 2.9e-11 43.3 0.6 4.7e-06 26.6 0.0 3.9 4 0 0 4 4 4 2 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 AMD19720.1 - 0.00017 21.3 0.4 0.17 11.7 0.1 3.7 4 0 0 4 4 4 1 Tricorn protease PDZ domain Trypsin PF00089.21 AMD19720.1 - 0.0013 18.3 0.0 0.0035 16.9 0.0 1.7 1 1 0 1 1 1 1 Trypsin DUF31 PF01732.11 AMD19720.1 - 0.021 14.1 0.4 0.032 13.5 0.2 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S46 PF10459.4 AMD19720.1 - 0.023 13.1 0.6 1.1 7.5 0.0 2.1 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S7 PF00949.16 AMD19720.1 - 0.051 12.9 0.2 0.11 11.9 0.1 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease ORC6 PF05460.8 AMD19721.1 - 6e-93 311.7 0.2 7.4e-93 311.4 0.2 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) N-SET PF11764.3 AMD19722.1 - 6.2e-46 156.3 0.7 6.2e-46 156.3 0.5 3.2 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.23 AMD19722.1 - 5.7e-22 78.7 0.2 5.7e-22 78.7 0.1 3.8 3 2 0 3 3 3 1 SET domain SET_assoc PF11767.3 AMD19722.1 - 9.4e-19 66.4 0.2 9.4e-19 66.4 0.1 2.3 3 0 0 3 3 3 1 Histone lysine methyltransferase SET associated Tom5 PF10642.4 AMD19722.1 - 0.2 11.3 1.0 0.52 9.9 0.7 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase TSA PF03249.8 AMD19722.1 - 0.33 9.4 1.4 0.44 9.0 0.0 1.8 2 0 0 2 2 2 0 Type specific antigen MutS_V PF00488.16 AMD19723.1 - 6.2e-74 248.3 0.0 1e-73 247.6 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 AMD19723.1 - 5.8e-35 120.9 3.0 1.3e-34 119.8 2.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 AMD19723.1 - 2.2e-27 95.3 0.0 4.8e-27 94.2 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 AMD19723.1 - 3.6e-12 46.5 0.0 1e-11 45.0 0.0 1.8 1 0 0 1 1 1 1 MutS domain II AAA_23 PF13476.1 AMD19723.1 - 3.6 7.8 10.6 0.63 10.3 0.0 3.4 3 1 0 3 3 3 0 AAA domain Gar1 PF04410.9 AMD19724.1 - 7.1e-47 158.7 0.6 7.1e-47 158.7 0.4 1.8 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region Spc97_Spc98 PF04130.8 AMD19725.1 - 1.2e-71 241.6 17.9 1.2e-71 241.6 12.4 2.0 3 0 0 3 3 3 1 Spc97 / Spc98 family Microtub_assoc PF07989.6 AMD19725.1 - 0.066 13.0 5.7 0.089 12.6 2.4 2.4 2 0 0 2 2 2 0 Microtubule associated DUF3402 PF11882.3 AMD19726.1 - 1.8e-89 300.6 17.5 9.9e-89 298.2 9.1 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3402) N1221 PF07923.8 AMD19726.1 - 6.8e-70 235.2 4.3 1.4e-69 234.2 3.0 1.5 1 0 0 1 1 1 1 N1221-like protein Vac_Fusion PF02346.11 AMD19726.1 - 0.086 12.2 1.4 0.56 9.6 0.1 3.0 2 1 1 3 3 3 0 Chordopoxvirus fusion protein AD PF09793.4 AMD19727.1 - 1e-24 86.1 0.7 1.7e-24 85.4 0.1 1.7 2 0 0 2 2 2 1 Anticodon-binding domain NAGLU PF05089.7 AMD19727.1 - 0.11 11.2 0.0 0.23 10.1 0.0 1.5 2 0 0 2 2 2 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain DSPc PF00782.15 AMD19728.1 - 8.9e-11 41.5 0.0 1.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 AMD19728.1 - 0.0061 16.6 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.22 AMD19728.1 - 0.031 13.6 0.0 0.07 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 AMD19728.1 - 0.06 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family AAA_18 PF13238.1 AMD19729.1 - 6.3e-07 29.7 0.0 2.1e-06 28.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD19729.1 - 2e-06 28.6 0.1 9.1e-06 26.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 AMD19729.1 - 0.00087 18.9 0.1 0.0024 17.4 0.1 1.6 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.1 AMD19729.1 - 0.0084 15.9 0.0 0.048 13.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF927 PF06048.6 AMD19729.1 - 0.016 14.4 0.0 0.083 12.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF927) AAA_28 PF13521.1 AMD19729.1 - 0.069 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 AMD19729.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF59 PF01883.14 AMD19730.1 - 3.2e-06 27.0 0.0 7.2e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF59 CDP-OH_P_transf PF01066.16 AMD19731.1 - 5.7e-19 68.2 2.9 5.7e-19 68.2 2.0 2.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Tom22 PF04281.8 AMD19732.1 - 3.7e-48 162.5 0.1 4.1e-48 162.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 GNAT_acetyltr_2 PF13718.1 AMD19733.1 - 2.4e-80 268.5 0.0 4.2e-80 267.6 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 AMD19733.1 - 4.6e-66 221.8 0.0 2.1e-65 219.6 0.0 2.2 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.6 AMD19733.1 - 2.2e-40 136.2 0.1 6.8e-40 134.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 AMD19733.1 - 2.7e-34 117.2 0.5 9e-34 115.6 0.4 1.9 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 AMD19733.1 - 0.0028 17.7 0.0 0.01 15.9 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_19 PF13245.1 AMD19733.1 - 0.066 12.9 0.0 0.93 9.2 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain Acetyltransf_1 PF00583.19 AMD19733.1 - 0.14 12.1 0.0 0.5 10.4 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family NDT80_PhoG PF05224.7 AMD19734.1 - 5.2e-68 228.7 0.6 1.4e-67 227.3 0.4 1.7 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family HIM1 PF08732.5 AMD19735.1 - 4.9e-119 397.4 0.0 5.9e-119 397.1 0.0 1.0 1 0 0 1 1 1 1 HIM1 Chlor_dismutase PF06778.7 AMD19735.1 - 0.013 15.1 0.0 2.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Chlorite dismutase CENP-O PF09496.5 AMD19736.1 - 2.4e-18 66.1 0.1 5.3e-18 65.0 0.1 1.6 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component Microtub_assoc PF07989.6 AMD19736.1 - 0.035 13.9 4.3 0.35 10.7 0.9 3.2 3 0 0 3 3 3 0 Microtubule associated Scs3p PF10261.4 AMD19737.1 - 1.7e-32 112.3 21.0 1.1e-31 109.6 14.5 2.2 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.16 AMD19737.1 - 0.00082 19.0 2.8 0.0017 18.0 1.9 1.6 1 0 0 1 1 1 1 PAP2 superfamily Prenyltrans PF00432.16 AMD19738.1 - 4.7e-27 93.2 0.7 5e-08 32.3 0.1 4.4 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 AMD19738.1 - 1.1e-26 93.4 0.1 1.5e-14 54.3 0.1 4.9 3 2 2 5 5 5 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 AMD19738.1 - 4.3e-23 81.3 0.0 3.9e-13 49.3 0.1 5.5 3 3 3 6 6 6 2 Prenyltransferase-like Pec_lyase PF09492.5 AMD19738.1 - 0.00028 20.1 0.0 0.13 11.3 0.0 3.1 2 2 1 3 3 3 2 Pectic acid lyase A2M_comp PF07678.9 AMD19738.1 - 0.077 12.2 0.0 0.59 9.3 0.0 2.1 1 1 0 2 2 2 0 A-macroglobulin complement component Ubiq-assoc PF09145.5 AMD19739.1 - 6.1e-13 48.4 0.5 1.2e-12 47.4 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin-associated TPR_11 PF13414.1 AMD19739.1 - 0.00017 21.1 0.1 0.14 11.8 0.0 3.2 3 0 0 3 3 3 1 TPR repeat DnaJ PF00226.26 AMD19739.1 - 0.00045 19.8 0.0 0.0012 18.5 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 AMD19739.1 - 0.03 14.2 0.2 21 5.3 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 AMD19739.1 - 0.09 12.7 0.0 1.8 8.5 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat PTPLA PF04387.9 AMD19740.1 - 0.011 15.1 0.4 0.018 14.4 0.3 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA DC_STAMP PF07782.8 AMD19740.1 - 0.033 13.8 0.1 0.049 13.2 0.1 1.2 1 0 0 1 1 1 0 DC-STAMP-like protein SufE PF02657.10 AMD19740.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Fe-S metabolism associated domain Nop10p PF04135.7 AMD19741.1 - 1.8e-22 78.7 0.2 2.1e-22 78.6 0.1 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family DASH_Dad4 PF08650.5 AMD19742.1 - 4.4e-39 132.2 5.7 4.9e-39 132.0 3.9 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 NPV_P10 PF05531.7 AMD19742.1 - 0.0025 17.9 0.5 0.0029 17.8 0.3 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein DUF3251 PF11622.3 AMD19742.1 - 0.0095 15.3 0.3 0.011 15.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3251) FAM117 PF15388.1 AMD19742.1 - 0.0097 15.1 0.6 0.01 15.1 0.4 1.0 1 0 0 1 1 1 1 Protein Family FAM117 CagA PF03507.8 AMD19742.1 - 0.037 13.8 0.0 0.044 13.6 0.0 1.1 1 0 0 1 1 1 0 CagA exotoxin DUF1758 PF05585.7 AMD19742.1 - 0.056 12.9 0.1 0.059 12.9 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase (DUF1758) DASH_Dad3 PF08656.5 AMD19742.1 - 0.057 13.1 0.3 0.077 12.6 0.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad3 DivIC PF04977.10 AMD19742.1 - 0.064 12.7 1.5 0.088 12.3 1.0 1.3 1 1 0 1 1 1 0 Septum formation initiator RTX PF02382.10 AMD19742.1 - 0.075 11.2 0.4 0.082 11.1 0.3 1.0 1 0 0 1 1 1 0 RTX N-terminal domain TMF_TATA_bd PF12325.3 AMD19742.1 - 0.091 12.4 0.3 0.09 12.5 0.2 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Peripla_BP_2 PF01497.13 AMD19742.1 - 0.12 11.4 0.1 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Periplasmic binding protein DUF4206 PF13901.1 AMD19742.1 - 0.14 11.7 0.2 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) Oxysterol_BP PF01237.13 AMD19743.1 - 1.9e-101 339.1 0.1 1.4e-100 336.2 0.0 2.2 2 0 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.1 AMD19743.1 - 2.3e-32 110.9 0.9 5.7e-32 109.6 0.6 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 AMD19743.1 - 0.00013 22.1 0.6 0.0004 20.5 0.4 2.0 1 0 0 1 1 1 1 PH domain PH_3 PF14593.1 AMD19743.1 - 0.00067 19.5 0.7 0.0013 18.5 0.5 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 AMD19743.1 - 0.093 12.9 7.5 2 8.7 5.2 2.9 1 1 0 1 1 1 0 Pleckstrin homology domain Asparaginase PF00710.15 AMD19744.1 - 1.5e-71 240.8 0.0 1.9e-71 240.4 0.0 1.0 1 0 0 1 1 1 1 Asparaginase Ribosomal_L19 PF01245.15 AMD19744.1 - 0.12 12.2 0.0 11 5.8 0.0 2.9 3 0 0 3 3 3 0 Ribosomal protein L19 CN_hydrolase PF00795.17 AMD19745.1 - 3e-27 95.1 0.0 4.6e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.12 AMD19745.1 - 6.5e-25 87.4 0.0 2.5e-24 85.5 0.0 1.8 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 AMD19745.1 - 0.025 14.0 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase Abhydrolase_6 PF12697.2 AMD19746.1 - 7.5e-22 78.3 0.0 1.1e-21 77.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD19746.1 - 2.2e-13 50.2 0.0 3.3e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AMD19746.1 - 4.5e-09 36.2 0.0 7.2e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 AMD19746.1 - 0.00027 21.2 0.1 0.0024 18.1 0.0 2.1 1 1 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.20 AMD19746.1 - 0.00092 18.8 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 AMD19746.1 - 0.0017 17.9 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.3 AMD19746.1 - 0.0065 16.3 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase Cutinase PF01083.17 AMD19746.1 - 0.009 15.7 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Cutinase DUF676 PF05057.9 AMD19746.1 - 0.0093 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF2305 PF10230.4 AMD19746.1 - 0.014 14.7 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) DUF2974 PF11187.3 AMD19746.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Chlorophyllase2 PF12740.2 AMD19746.1 - 0.065 12.1 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_3 PF07859.8 AMD19746.1 - 0.08 12.5 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.6 AMD19746.1 - 0.1 12.2 0.0 7.2 6.2 0.0 2.2 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ser_hydrolase PF06821.8 AMD19746.1 - 0.16 11.5 0.0 1 8.9 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Peptidase_M1 PF01433.15 AMD19747.1 - 8.8e-121 403.6 2.6 1.1e-119 400.0 1.8 2.1 1 1 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 AMD19747.1 - 3.5e-31 108.6 0.0 5.2e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 AMD19747.1 - 7.9e-14 51.7 0.1 2.2e-13 50.3 0.0 1.8 1 1 0 1 1 1 1 Peptidase MA superfamily PBP PF01161.15 AMD19748.1 - 1.7e-12 47.4 0.0 2.9e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ATP-synt_E PF05680.7 AMD19749.1 - 7.7e-21 73.8 0.1 8.2e-21 73.7 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain SpoIIE PF07228.7 AMD19750.1 - 4e-32 111.4 0.0 5.4e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 AMD19750.1 - 1.9e-06 27.4 0.0 3.8e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 AMD19750.1 - 2.5e-06 27.0 0.1 0.018 14.4 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C MIF4G PF02854.14 AMD19751.1 - 2.3e-39 134.9 28.4 4.1e-19 68.8 0.1 3.8 4 0 0 4 4 4 3 MIF4G domain Upf2 PF04050.9 AMD19751.1 - 3.4e-12 46.4 28.7 1.4e-10 41.2 19.9 2.5 1 1 0 1 1 1 1 Up-frameshift suppressor 2 FYVE PF01363.16 AMD19752.1 - 5.9e-18 64.5 24.5 9.6e-16 57.4 3.8 2.8 3 0 0 3 3 3 2 FYVE zinc finger EutA PF06277.6 AMD19752.1 - 0.19 10.3 2.4 2.2 6.7 0.3 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation protein EutA Med4 PF10018.4 AMD19752.1 - 0.88 8.9 4.6 0.23 10.8 0.6 1.9 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 zf-met PF12874.2 AMD19752.1 - 2 8.7 0.0 2 8.7 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 AMD19752.1 - 3.8 8.0 0.0 3.8 8.0 0.0 5.0 4 1 1 5 5 5 0 Zinc finger, C2H2 type Pox_A_type_inc PF04508.7 AMD19752.1 - 9.9 6.2 10.3 0.78 9.6 0.2 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat ABA_GPCR PF12430.3 AMD19753.1 - 1.8e-55 187.1 5.9 1.8e-55 187.1 4.1 2.4 3 0 0 3 3 3 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 AMD19753.1 - 1.4e-12 47.4 0.3 5.8e-12 45.4 0.2 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3735) Sigma70_r1_2 PF00140.15 AMD19753.1 - 0.025 14.2 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 PGC7_Stella PF15549.1 AMD19753.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain DUF2427 PF10348.4 AMD19753.1 - 0.12 11.9 4.4 0.72 9.4 3.1 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) WD40 PF00400.27 AMD19754.1 - 5.8e-15 54.5 13.5 0.076 12.9 0.1 9.5 10 0 0 10 10 10 6 WD domain, G-beta repeat Cnd3 PF12719.2 AMD19755.1 - 7.8e-102 340.2 12.6 5.3e-101 337.5 2.8 3.8 3 1 1 4 4 4 2 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 AMD19755.1 - 5.4e-13 49.0 0.0 2e-07 31.2 0.0 4.2 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.17 AMD19755.1 - 4.7e-10 38.6 0.3 1.1 9.5 0.0 6.0 5 0 0 5 5 5 4 HEAT repeat HEAT_EZ PF13513.1 AMD19755.1 - 4.6e-05 23.7 0.4 16 6.1 0.0 5.7 4 1 2 6 6 6 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 AMD19755.1 - 0.017 15.4 0.1 0.24 11.8 0.1 3.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Pkinase PF00069.20 AMD19756.1 - 1.1e-45 155.7 0.1 2e-45 155.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.7 AMD19756.1 - 3.8e-41 139.9 0.2 1.4e-40 138.1 0.1 2.0 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.12 AMD19756.1 - 7.8e-25 87.4 0.0 1.3e-22 80.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.1 AMD19756.1 - 0.00024 20.6 0.0 40 3.5 0.0 2.2 1 1 0 1 1 1 0 PQQ-like domain PQQ PF01011.16 AMD19756.1 - 0.0057 16.1 0.3 3.2 7.4 0.0 3.2 3 0 0 3 3 3 2 PQQ enzyme repeat Kdo PF06293.9 AMD19756.1 - 0.0067 15.5 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Swi5 PF07061.6 AMD19757.1 - 1.5e-19 69.5 1.3 1.9e-19 69.2 0.9 1.1 1 0 0 1 1 1 1 Swi5 Y1_Tnp PF01797.11 AMD19757.1 - 0.093 12.5 0.3 0.24 11.2 0.2 1.7 1 1 0 1 1 1 0 Transposase IS200 like Spc24 PF08286.6 AMD19757.1 - 0.13 11.9 1.3 0.15 11.7 0.9 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 GRAM PF02893.15 AMD19758.1 - 2.2e-14 52.7 0.0 4.5e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 GRAM domain NolV PF06635.7 AMD19758.1 - 0.26 10.4 0.1 0.51 9.4 0.1 1.4 1 0 0 1 1 1 0 Nodulation protein NolV Skp1 PF01466.14 AMD19759.1 - 6.4e-36 122.2 0.6 6.4e-36 122.2 0.5 1.6 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 AMD19759.1 - 3.2e-13 49.5 0.2 6.9e-12 45.2 0.2 2.3 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain Peroxin-3 PF04882.7 AMD19760.1 - 5.6e-93 312.0 7.4 6.8e-93 311.7 5.2 1.1 1 0 0 1 1 1 1 Peroxin-3 Secretin_N_2 PF07655.8 AMD19760.1 - 0.02 15.2 0.4 0.02 15.2 0.3 1.9 2 0 0 2 2 2 0 Secretin N-terminal domain Ctr PF04145.10 AMD19760.1 - 0.9 9.5 5.7 2.3 8.2 1.6 2.9 3 1 0 3 3 3 0 Ctr copper transporter family Sas10_Utp3 PF04000.10 AMD19761.1 - 8.2e-08 32.3 5.6 8.2e-08 32.3 3.8 2.1 3 0 0 3 3 3 1 Sas10/Utp3/C1D family SNF5 PF04855.7 AMD19761.1 - 0.041 13.3 1.0 0.067 12.6 0.7 1.3 1 0 0 1 1 1 0 SNF5 / SMARCB1 / INI1 NUC129 PF08157.6 AMD19761.1 - 0.064 13.1 1.6 1.4 8.9 0.1 2.5 2 0 0 2 2 2 0 NUC129 domain Alba PF01918.16 AMD19761.1 - 0.47 10.0 3.8 6.6 6.4 0.4 2.6 2 1 0 2 2 2 0 Alba DUF3278 PF11683.3 AMD19761.1 - 1 9.3 4.9 1.4 8.9 2.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) Rpp20 PF12328.3 AMD19761.1 - 4.5 6.9 10.7 2.1 8.0 4.3 2.4 2 1 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P GlutR_dimer PF00745.15 AMD19761.1 - 7.1 6.6 9.1 1.6 8.7 1.0 2.8 3 1 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain Thioredoxin_7 PF13899.1 AMD19762.1 - 9.3e-20 70.4 0.1 1.8e-19 69.5 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.15 AMD19762.1 - 2.6e-18 65.8 0.0 5.9e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 AMD19762.1 - 2e-13 49.6 0.1 3.6e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Thioredox_DsbH PF03190.10 AMD19762.1 - 0.0034 17.1 0.0 0.0061 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Peptidase_C13 PF01650.13 AMD19763.1 - 1.1e-45 155.9 1.3 1.6e-45 155.3 0.9 1.2 1 0 0 1 1 1 1 Peptidase C13 family Pkinase PF00069.20 AMD19764.1 - 1.4e-50 171.9 0.5 6.5e-50 169.6 0.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19764.1 - 1.1e-25 90.2 0.2 2.3e-24 85.8 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD19764.1 - 5.5e-07 28.8 0.0 8.5e-07 28.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD19764.1 - 0.068 12.2 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD19764.1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ResIII PF04851.10 AMD19765.1 - 9.8e-19 67.8 0.7 9.8e-19 67.8 0.5 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 AMD19765.1 - 6.2e-16 58.3 0.2 1.3e-15 57.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19765.1 - 3.1e-13 49.3 0.1 1.2e-12 47.4 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2075 PF09848.4 AMD19765.1 - 6.6e-05 22.0 0.0 0.00014 21.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 AMD19765.1 - 0.00012 22.2 0.2 0.0011 19.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain SNF2_N PF00176.18 AMD19765.1 - 0.001 17.9 0.1 0.0017 17.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Flavi_DEAD PF07652.9 AMD19765.1 - 0.067 12.9 1.0 0.25 11.0 0.1 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain DUF2731 PF10806.3 AMD19766.1 - 1.2e-31 109.5 0.2 2e-31 108.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2731) Seipin PF06775.9 AMD19766.1 - 0.063 12.7 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Putative adipose-regulatory protein (Seipin) STE PF02200.11 AMD19767.1 - 3.8e-60 200.8 2.9 6.1e-60 200.1 2.0 1.3 1 0 0 1 1 1 1 STE like transcription factor RXT2_N PF08595.6 AMD19767.1 - 1.6 8.5 8.9 0.27 11.0 0.8 2.6 2 0 0 2 2 2 0 RXT2-like, N-terminal Ribosomal_60s PF00428.14 AMD19767.1 - 2 8.8 7.4 0.42 11.0 2.2 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Tcf25 PF04910.9 AMD19768.1 - 1.5e-68 231.3 0.6 2.2e-68 230.8 0.4 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Ipi1_N PF12333.3 AMD19769.1 - 6.6e-26 90.2 1.5 3.5e-25 87.9 0.4 2.4 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation RRM_1 PF00076.17 AMD19770.1 - 4.2e-45 151.2 0.1 2.5e-17 62.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD19770.1 - 1.7e-28 98.3 0.0 3e-09 36.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD19770.1 - 1.6e-17 63.0 0.0 2.9e-09 36.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 AMD19770.1 - 0.00095 18.9 0.0 0.0026 17.5 0.0 1.7 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.1 AMD19770.1 - 0.0067 16.1 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-C2H2 PF00096.21 AMD19771.1 - 1.2e-08 34.7 11.2 0.00025 21.1 1.6 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD19771.1 - 1.9e-05 24.6 1.0 1.9e-05 24.6 0.7 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 AMD19771.1 - 0.00017 21.6 11.1 0.023 14.9 1.2 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.2 AMD19771.1 - 0.003 17.7 2.6 0.11 12.7 0.3 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD19771.1 - 0.012 15.6 2.6 0.077 13.1 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 AMD19771.1 - 0.65 10.3 5.1 5 7.5 0.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain SNF2_N PF00176.18 AMD19772.1 - 3.9e-77 258.9 0.7 8.6e-77 257.8 0.5 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD19772.1 - 2e-14 53.2 0.0 7.1e-14 51.4 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HSA PF07529.8 AMD19772.1 - 3.2e-14 52.4 8.2 3.2e-14 52.4 5.7 2.6 2 0 0 2 2 2 1 HSA DEAD PF00270.24 AMD19772.1 - 5.3e-07 29.2 0.0 2.2e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase RhoGEF PF00621.15 AMD19773.1 - 8e-09 35.6 0.1 1.6e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain Brix PF04427.13 AMD19774.1 - 1.5e-42 145.4 2.7 2.2e-42 144.8 1.9 1.2 1 0 0 1 1 1 1 Brix domain 7TM_transglut PF14402.1 AMD19774.1 - 0.1 11.4 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase MMR_HSR1 PF01926.18 AMD19776.1 - 8.2e-17 61.2 0.1 5.7e-16 58.5 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD19776.1 - 2e-07 30.6 0.0 2.1e-06 27.3 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 AMD19776.1 - 6.6e-06 26.0 0.1 0.084 12.6 0.0 2.8 2 1 1 3 3 3 2 Dynamin family SRPRB PF09439.5 AMD19776.1 - 8.4e-06 25.1 0.1 3.7e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 AMD19776.1 - 1.3e-05 24.4 0.0 2.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 AMD19776.1 - 0.00029 20.1 0.1 0.00056 19.2 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.4 AMD19776.1 - 0.012 15.1 0.0 0.052 13.0 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.13 AMD19776.1 - 0.015 14.3 0.0 0.026 13.5 0.0 1.3 1 0 0 1 1 1 0 Septin Miro PF08477.8 AMD19776.1 - 0.045 14.2 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Gar1 PF04410.9 AMD19777.1 - 1.3e-43 148.1 0.2 1.3e-43 148.1 0.1 1.9 1 1 0 2 2 2 1 Gar1/Naf1 RNA binding region Ribosomal_S15 PF00312.17 AMD19778.1 - 7e-24 83.3 1.2 1.1e-23 82.7 0.2 1.9 2 0 0 2 2 2 1 Ribosomal protein S15 DUF4093 PF13331.1 AMD19778.1 - 0.005 17.0 0.4 0.015 15.4 0.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4093) DUF3487 PF11990.3 AMD19778.1 - 0.083 12.2 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) DFF40 PF09230.5 AMD19778.1 - 3.6 6.8 7.4 0.62 9.3 2.2 1.7 2 0 0 2 2 2 0 DNA fragmentation factor 40 kDa Abhydrolase_1 PF00561.15 AMD19779.1 - 9.5e-18 64.5 0.0 9.2e-16 58.0 0.0 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 AMD19779.1 - 1.5e-09 38.0 0.0 5.9e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 AMD19779.1 - 0.0065 15.9 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Putative esterase ING PF12998.2 AMD19780.1 - 5.7e-19 68.3 4.5 1.1e-18 67.4 3.1 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 AMD19780.1 - 1.8e-10 40.3 9.3 3.1e-10 39.5 6.5 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 AMD19780.1 - 0.0034 17.5 2.2 0.009 16.1 1.5 1.8 1 0 0 1 1 1 1 PHD-like zinc-binding domain DUF1878 PF08963.5 AMD19780.1 - 0.085 13.0 1.0 0.25 11.5 0.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1878) DUF2296 PF10058.4 AMD19780.1 - 0.25 11.1 2.6 0.56 9.9 1.8 1.6 1 0 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) NifU_N PF01592.11 AMD19781.1 - 5e-55 184.8 0.0 6.2e-55 184.5 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain RNA_pol_Rpb8 PF03870.10 AMD19782.1 - 1.3e-42 145.2 0.1 1.5e-42 145.0 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 Velvet PF11754.3 AMD19782.1 - 0.051 13.1 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Velvet factor DUF2407_C PF13373.1 AMD19783.1 - 1.3e-40 138.5 2.0 1.9e-40 137.9 0.6 1.8 2 0 0 2 2 2 1 DUF2407 C-terminal domain DUF2407 PF10302.4 AMD19783.1 - 1.3e-16 60.5 0.1 2.8e-16 59.4 0.0 1.6 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain DUF2453 PF10507.4 AMD19783.1 - 0.035 13.8 0.7 0.16 11.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2453) Death PF00531.17 AMD19783.1 - 0.19 11.5 0.8 0.56 10.0 0.0 2.0 2 0 0 2 2 2 0 Death domain Mito_carr PF00153.22 AMD19784.1 - 1.3e-69 229.9 0.2 4.8e-26 90.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Acyl_transf_1 PF00698.16 AMD19785.1 - 0.00057 19.3 0.0 0.0011 18.3 0.0 1.4 1 1 0 1 1 1 1 Acyl transferase domain Zn_clus PF00172.13 AMD19786.1 - 9.5e-05 22.2 12.8 0.0002 21.1 8.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3580 PF12117.3 AMD19786.1 - 0.033 14.1 0.2 0.075 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) CtaG_Cox11 PF04442.9 AMD19787.1 - 1.8e-58 196.6 0.1 2.8e-58 196.0 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Ribosomal_L18p PF00861.17 AMD19788.1 - 3.2e-45 153.1 2.0 1e-44 151.5 0.0 2.4 3 0 0 3 3 3 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 AMD19788.1 - 7.3e-34 116.2 3.9 7.3e-34 116.2 2.7 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.1 AMD19788.1 - 0.012 15.5 0.2 0.86 9.6 0.0 2.8 3 0 0 3 3 3 0 Threonine synthase N terminus SPT6_acidic PF14632.1 AMD19788.1 - 2.9 8.1 6.1 8.8 6.5 4.3 1.8 1 1 0 1 1 1 0 Acidic N-terminal SPT6 DPPIV_N PF00930.16 AMD19789.1 - 3.1e-86 289.1 6.1 4.7e-86 288.5 4.2 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 AMD19789.1 - 4.3e-44 150.2 0.3 9e-44 149.2 0.2 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 AMD19789.1 - 5.3e-05 23.0 0.0 9.5e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family PAF-AH_p_II PF03403.8 AMD19789.1 - 0.0031 15.8 0.0 0.076 11.3 0.0 2.2 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_6 PF12697.2 AMD19789.1 - 0.0065 16.3 0.0 0.038 13.8 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family ARID PF01388.16 AMD19790.1 - 2.3e-19 69.0 0.1 2.3e-19 69.0 0.0 3.1 2 1 0 2 2 2 1 ARID/BRIGHT DNA binding domain Glyco_transf_34 PF05637.7 AMD19791.1 - 1.4e-72 244.0 0.0 1.7e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family TadE PF07811.7 AMD19791.1 - 8.6 6.3 5.8 15 5.5 4.1 1.4 1 0 0 1 1 1 0 TadE-like protein TPR_11 PF13414.1 AMD19792.1 - 7.4e-24 83.1 10.6 5.6e-11 41.9 0.1 4.2 2 2 2 4 4 4 4 TPR repeat TPR_2 PF07719.12 AMD19792.1 - 2.2e-20 70.8 2.8 2.8e-06 26.7 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 AMD19792.1 - 2.3e-20 71.2 2.1 3.1e-07 29.7 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 AMD19792.1 - 1.4e-16 59.4 0.2 2.8e-05 24.3 0.3 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 AMD19792.1 - 2.9e-14 51.9 0.6 0.02 15.0 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 AMD19792.1 - 9.7e-14 51.6 2.8 2.1e-06 28.2 0.0 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 AMD19792.1 - 1.8e-12 47.3 0.7 0.00067 19.9 0.1 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 AMD19792.1 - 1.5e-10 40.8 2.6 7.6e-06 25.7 0.5 3.2 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_20 PF14561.1 AMD19792.1 - 8.2e-08 32.2 1.4 0.021 14.9 0.0 4.5 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 AMD19792.1 - 5.1e-07 29.0 1.7 0.29 10.9 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 AMD19792.1 - 6.8e-07 29.0 0.1 0.0033 17.2 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD19792.1 - 3.2e-05 23.4 0.0 0.093 12.5 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 AMD19792.1 - 5.2e-05 23.3 0.9 0.0013 18.7 0.2 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 AMD19792.1 - 0.00052 20.2 0.2 15 6.3 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat CCP_MauG PF03150.9 AMD19792.1 - 0.078 13.2 1.4 0.13 12.6 0.3 1.9 2 0 0 2 2 1 0 Di-haem cytochrome c peroxidase Fis1_TPR_C PF14853.1 AMD19792.1 - 1.5 8.7 4.4 2 8.3 0.2 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.1 AMD19792.1 - 7.3 6.6 6.0 4.6 7.3 0.3 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat DEAD PF00270.24 AMD19793.1 - 2e-44 151.0 0.1 2.8e-42 144.0 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19793.1 - 2e-25 88.4 0.6 4.9e-25 87.1 0.3 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD19793.1 - 0.00017 21.4 0.0 0.00056 19.7 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RRM_5 PF13893.1 AMD19794.1 - 3.9e-06 26.6 0.3 8.9e-06 25.4 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD19794.1 - 4.8e-06 26.1 0.2 1.1e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 AMD19794.1 - 0.0048 16.6 0.0 0.0096 15.6 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_6 PF14259.1 AMD19794.1 - 0.07 13.1 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 AMD19794.1 - 0.6 9.8 5.0 1.2 8.8 3.5 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pyrophosphatase PF00719.14 AMD19795.1 - 3.4e-52 176.0 0.1 4.5e-52 175.6 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase PRAI PF00697.17 AMD19796.1 - 5.5e-58 195.7 0.0 6.3e-58 195.5 0.0 1.0 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Histone PF00125.19 AMD19797.1 - 5.2e-30 103.3 0.7 8.5e-30 102.7 0.5 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 AMD19797.1 - 9.4e-07 28.9 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 AMD19797.1 - 0.002 18.1 1.0 0.0025 17.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 AMD19797.1 - 0.058 13.1 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.19 AMD19798.1 - 2.9e-14 52.9 0.2 3.5e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 AMD19798.1 - 5.5e-05 23.0 0.2 8e-05 22.5 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 AMD19798.1 - 6.6e-05 23.0 0.1 9.7e-05 22.4 0.1 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 AMD19798.1 - 8e-05 22.6 0.1 0.00015 21.7 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 AMD19798.1 - 0.003 16.8 0.0 0.0032 16.7 0.0 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 AMD19798.1 - 0.0046 16.6 0.0 0.0059 16.3 0.0 1.3 1 1 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.8 AMD19798.1 - 0.036 14.3 0.1 0.062 13.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.10 AMD19798.1 - 0.14 11.9 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Tcp11 PF05794.8 AMD19799.1 - 4e-120 401.5 5.7 2.3e-119 399.0 4.0 2.0 1 1 0 1 1 1 1 T-complex protein 11 Sel1 PF08238.7 AMD19800.1 - 3.9e-07 30.4 6.1 3.6e-05 24.2 0.2 3.3 3 0 0 3 3 3 2 Sel1 repeat Maf1 PF09174.5 AMD19801.1 - 1.5e-49 168.2 2.7 2.8e-46 157.6 0.0 2.7 2 1 0 2 2 2 2 Maf1 regulator Rad51 PF08423.6 AMD19802.1 - 2e-31 108.8 0.0 9.5e-31 106.6 0.0 1.9 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 AMD19802.1 - 1.8e-10 40.5 0.0 3.2e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 AMD19802.1 - 2.4e-06 26.8 0.0 4.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 KaiC CobU PF02283.11 AMD19802.1 - 0.00022 20.6 0.2 0.0052 16.2 0.1 2.5 1 1 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase RecA PF00154.16 AMD19802.1 - 0.0065 15.5 0.2 0.019 14.0 0.2 1.8 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_22 PF13401.1 AMD19802.1 - 0.02 15.0 0.1 0.047 13.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain FliD_N PF02465.13 AMD19802.1 - 0.61 10.4 8.7 2.3 8.6 4.7 2.5 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Aldedh PF00171.17 AMD19803.1 - 2.8e-161 536.9 0.2 3.2e-161 536.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 AMD19803.1 - 0.0013 17.9 0.1 0.0072 15.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) Nab2 PF11517.3 AMD19804.1 - 7.7e-47 157.8 1.1 1.4e-46 157.0 0.8 1.4 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.1 AMD19804.1 - 5.3e-08 32.5 64.0 1.3e-05 24.9 3.0 6.6 6 0 0 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type DUF2508 PF10704.4 AMD19804.1 - 0.062 13.4 0.1 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) Ribosomal_S5 PF00333.15 AMD19805.1 - 8.6e-29 99.0 5.3 1.5e-28 98.3 1.8 2.4 3 0 0 3 3 3 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 AMD19805.1 - 2.2e-21 74.9 0.1 3.9e-21 74.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain E3_binding PF02817.12 AMD19805.1 - 0.12 12.0 1.1 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 e3 binding domain S1-P1_nuclease PF02265.11 AMD19806.1 - 0.023 14.3 0.1 0.029 13.9 0.1 1.1 1 0 0 1 1 1 0 S1/P1 Nuclease SICA_alpha PF12887.2 AMD19806.1 - 0.031 14.0 1.2 0.042 13.5 0.8 1.2 1 0 0 1 1 1 0 SICA extracellular alpha domain Gp-FAR-1 PF05823.7 AMD19806.1 - 0.033 14.1 0.3 0.048 13.6 0.2 1.3 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF883 PF05957.8 AMD19806.1 - 0.8 10.1 3.4 2.5 8.5 1.7 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Mon1 PF03164.9 AMD19807.1 - 6.9e-108 360.9 0.3 8.6e-108 360.5 0.2 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 GATA PF00320.22 AMD19808.1 - 7.3e-10 38.0 4.3 1.2e-09 37.2 3.0 1.4 1 0 0 1 1 1 1 GATA zinc finger Glyco_hydro_31 PF01055.21 AMD19809.1 - 1.2e-138 462.7 0.0 1.7e-138 462.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 AMD19809.1 - 4.2e-18 64.9 0.0 1.3e-17 63.3 0.0 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like GIY-YIG PF01541.19 AMD19810.1 - 6.4e-07 29.6 0.0 1.5e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain MTHFR PF02219.12 AMD19811.1 - 8.4e-117 389.3 0.0 1.1e-116 388.9 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Tyr-DNA_phospho PF06087.7 AMD19812.1 - 2.4e-91 306.5 0.0 2.8e-91 306.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase AMP-binding PF00501.23 AMD19813.1 - 1.2e-76 257.8 0.0 4.5e-76 255.9 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.1 AMD19813.1 - 6e-16 59.1 0.1 1.2e-15 58.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.8 AMD19813.1 - 0.03 12.8 0.2 0.094 11.2 0.1 1.7 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Transket_pyr PF02779.19 AMD19814.1 - 1.5e-47 161.4 0.1 2.9e-47 160.4 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 AMD19814.1 - 1.3e-36 125.2 0.0 3.1e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain Acatn PF13000.2 AMD19815.1 - 3.7e-204 679.3 16.4 4.2e-204 679.1 11.4 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Scs3p PF10261.4 AMD19816.1 - 6e-66 221.8 14.6 9.3e-66 221.2 10.1 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Med31 PF05669.7 AMD19817.1 - 4.9e-31 106.5 0.8 5.6e-31 106.3 0.5 1.1 1 0 0 1 1 1 1 SOH1 CPSase_L_D2 PF02786.12 AMD19818.1 - 7.5e-83 276.9 0.4 1.3e-82 276.2 0.3 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 AMD19818.1 - 4.5e-65 218.7 0.0 7.2e-65 218.0 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 AMD19818.1 - 3.9e-36 123.5 0.0 8.5e-36 122.4 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 AMD19818.1 - 3.6e-30 104.1 0.0 1.3e-29 102.2 0.0 2.1 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 AMD19818.1 - 5.9e-26 91.5 0.0 1.8e-25 90.0 0.0 1.9 1 0 0 1 1 1 1 HMGL-like ATPgrasp_Ter PF15632.1 AMD19818.1 - 1e-21 77.0 0.1 3.3e-21 75.3 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl PF00364.17 AMD19818.1 - 3.3e-19 68.3 4.7 3.3e-19 68.3 3.3 3.2 3 0 0 3 3 3 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 AMD19818.1 - 4.5e-17 62.3 0.2 8.5e-17 61.4 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 AMD19818.1 - 2.4e-09 36.8 0.0 5.1e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 AMD19818.1 - 6.8e-08 32.0 0.4 1.6e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 AMD19818.1 - 7.5e-08 31.9 3.0 0.0032 17.1 0.5 2.9 1 1 1 2 2 2 2 Biotin-lipoyl like RimK PF08443.6 AMD19818.1 - 1.4e-06 27.9 0.1 4.7e-06 26.2 0.1 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 AMD19818.1 - 2.3e-06 27.5 0.0 5.7e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain HlyD_2 PF12700.2 AMD19818.1 - 0.0002 20.6 1.8 0.14 11.3 0.1 2.3 1 1 1 2 2 2 2 HlyD family secretion protein HlyD PF00529.15 AMD19818.1 - 0.0016 17.8 1.3 0.16 11.2 0.2 2.5 2 0 0 2 2 2 1 HlyD family secretion protein HlyD_3 PF13437.1 AMD19818.1 - 0.0021 18.3 4.5 2.6 8.4 0.0 3.9 3 0 0 3 3 3 2 HlyD family secretion protein RnfC_N PF13375.1 AMD19818.1 - 0.79 9.4 5.7 2.1 8.0 2.6 2.7 2 1 0 2 2 2 0 RnfC Barrel sandwich hybrid domain DASH_Duo1 PF08651.5 AMD19819.1 - 5.3e-26 90.0 2.2 5.5e-26 89.9 0.3 1.8 2 0 0 2 2 2 1 DASH complex subunit Duo1 Med1 PF10744.4 AMD19819.1 - 0.044 12.5 0.3 0.064 12.0 0.2 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription subunit 1 RasGEF_N PF00618.15 AMD19819.1 - 0.068 13.2 0.5 0.089 12.8 0.4 1.2 1 0 0 1 1 1 0 RasGEF N-terminal motif MHCassoc_trimer PF08831.5 AMD19819.1 - 0.21 11.4 1.0 3.6 7.5 0.1 2.3 1 1 1 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain APG12 PF04110.8 AMD19820.1 - 4.5e-26 90.8 0.1 7.4e-26 90.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 zf-C3Hc3H PF13891.1 AMD19820.1 - 0.029 14.4 0.4 0.058 13.4 0.3 1.5 1 0 0 1 1 1 0 Potential DNA-binding domain Kinetochor_Ybp2 PF08568.5 AMD19821.1 - 6e-107 358.4 14.7 7e-107 358.2 10.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin HUN PF08729.5 AMD19822.1 - 1.2e-14 53.8 0.3 3.6e-14 52.3 0.0 2.0 2 0 0 2 2 2 1 HPC2 and ubinuclein domain BCDHK_Adom3 PF10436.4 AMD19823.1 - 5.1e-31 107.3 1.7 8.3e-31 106.7 0.9 1.5 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 AMD19823.1 - 2e-10 40.3 0.0 1.1e-09 37.9 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GSH_synth_ATP PF03917.12 AMD19823.1 - 0.019 13.5 0.1 0.03 12.9 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain HATPase_c_3 PF13589.1 AMD19823.1 - 0.067 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UQ_con PF00179.21 AMD19824.1 - 1.7e-50 170.0 0.1 2e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 AMD19824.1 - 6.4e-06 25.9 0.0 8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 AMD19824.1 - 0.024 14.5 0.3 0.068 13.0 0.2 1.8 1 1 0 1 1 1 0 RWD domain UEV PF05743.8 AMD19824.1 - 0.027 14.1 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 UEV domain CBS PF00571.23 AMD19826.1 - 1.5e-22 79.1 2.4 2.4e-06 27.2 0.1 5.4 5 0 0 5 5 5 5 CBS domain FA_desaturase PF00487.19 AMD19827.1 - 1e-17 64.4 25.0 1e-17 64.4 17.4 1.8 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 AMD19827.1 - 1.5e-14 53.5 0.0 5.5e-14 51.7 0.0 2.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_7 PF13241.1 AMD19828.1 - 1.9e-25 89.0 0.0 3e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 AMD19828.1 - 2.2e-12 46.0 0.3 4.4e-12 45.1 0.2 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 AMD19828.1 - 3.3e-10 38.7 0.0 5.5e-10 38.0 0.0 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central 2-Hacid_dh_C PF02826.14 AMD19828.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 AMD19828.1 - 0.094 12.5 0.3 0.88 9.3 0.1 2.4 3 0 0 3 3 3 0 ThiF family DUF946 PF06101.6 AMD19829.1 - 3.8e-07 28.5 1.9 9.6e-07 27.1 1.3 1.6 1 1 0 1 1 1 1 Plant protein of unknown function (DUF946) GCR1_C PF12550.3 AMD19830.1 - 9.4e-20 70.2 0.3 3.3e-19 68.5 0.1 2.1 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes NCA2 PF08637.5 AMD19831.1 - 5.6e-91 304.4 4.3 8.1e-91 303.9 3.0 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 SH3_1 PF00018.23 AMD19832.1 - 6.4e-16 57.4 0.0 9.6e-16 56.9 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 AMD19832.1 - 6.3e-12 44.8 0.0 1.1e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 AMD19832.1 - 4.5e-11 42.0 0.0 6.8e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Pex14_N PF04695.8 AMD19832.1 - 4.3 7.3 9.7 26 4.8 5.4 2.5 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tmemb_170 PF10190.4 AMD19833.1 - 0.00011 22.2 5.4 0.00014 21.8 3.7 1.2 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF1129 PF06570.6 AMD19833.1 - 0.18 11.0 0.8 0.21 10.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) PepSY_TM PF03929.11 AMD19833.1 - 3.8 8.0 6.5 43 4.8 0.1 3.3 3 0 0 3 3 3 0 PepSY-associated TM helix Proteasome PF00227.21 AMD19834.1 - 1.3e-58 197.3 0.2 1.7e-58 197.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 AMD19834.1 - 2.1e-13 49.3 0.2 4e-13 48.3 0.2 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature RuvA_C PF07499.8 AMD19834.1 - 0.026 14.6 0.3 0.53 10.4 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain Lipocalin_6 PF13944.1 AMD19834.1 - 0.034 14.2 0.2 7.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Lipocalin-like domain DUF2533 PF10752.4 AMD19834.1 - 0.065 13.5 0.1 1.3 9.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2533) FF PF01846.14 AMD19835.1 - 3.3e-10 39.7 3.8 7.7e-08 32.1 0.2 3.7 3 1 0 3 3 3 2 FF domain WW PF00397.21 AMD19835.1 - 9.4e-10 38.1 2.7 2.5e-09 36.8 1.8 1.7 1 0 0 1 1 1 1 WW domain Pet20 PF08692.5 AMD19837.1 - 2.6e-07 30.6 0.0 2.9e-07 30.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial protein Pet20 UQ_con PF00179.21 AMD19838.1 - 1.6e-36 124.8 0.1 1.7e-36 124.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 AMD19838.1 - 0.018 14.7 0.9 0.026 14.2 0.6 1.5 1 1 0 1 1 1 0 UEV domain Band_7 PF01145.20 AMD19839.1 - 1.6e-24 86.7 1.2 2.7e-24 86.0 0.8 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family MARVEL PF01284.18 AMD19840.1 - 4.8e-26 91.2 13.5 5.9e-26 91.0 9.4 1.0 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.7 AMD19840.1 - 0.027 14.0 6.0 0.13 11.7 4.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF588) 7TM-7TMR_HD PF07698.6 AMD19840.1 - 0.031 13.7 10.7 0.011 15.1 4.3 2.0 2 0 0 2 2 2 0 7TM receptor with intracellular HD hydrolase EST1_DNA_bind PF10373.4 AMD19840.1 - 0.055 12.6 0.9 0.11 11.6 0.1 1.6 1 1 1 2 2 2 0 Est1 DNA/RNA binding domain Rhomboid PF01694.17 AMD19840.1 - 0.073 13.0 8.0 0.02 14.8 3.2 1.6 2 0 0 2 2 2 0 Rhomboid family DUF3792 PF12670.2 AMD19840.1 - 0.58 10.0 9.0 0.15 11.9 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3792) SNN_transmemb PF09049.5 AMD19840.1 - 1.6 8.4 4.8 3.3 7.4 0.2 2.4 2 0 0 2 2 2 0 Stannin transmembrane BAR_2 PF10455.4 AMD19842.1 - 1.1e-90 303.4 11.9 1.1e-90 303.4 8.3 1.3 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF4446 PF14584.1 AMD19842.1 - 0.021 14.6 4.8 0.038 13.8 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Rota_NS6 PF04866.7 AMD19842.1 - 0.026 14.5 0.5 6.3 6.8 0.1 2.5 2 0 0 2 2 2 0 Rotavirus non-structural protein 6 Herpes_UL6 PF01763.11 AMD19842.1 - 0.13 10.4 10.5 0.0082 14.3 2.4 2.1 2 0 0 2 2 2 0 Herpesvirus UL6 like DUF1664 PF07889.7 AMD19842.1 - 2.5 7.9 5.4 1.8 8.4 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) THOC7 PF05615.8 AMD19842.1 - 7 6.9 13.0 5.1 7.3 2.5 2.9 2 1 0 2 2 2 0 Tho complex subunit 7 SYF2 PF08231.7 AMD19843.1 - 5.7e-08 33.0 10.2 5.7e-08 33.0 7.1 1.8 2 0 0 2 2 2 1 SYF2 splicing factor GLTSCR1 PF15249.1 AMD19843.1 - 0.14 12.3 2.5 0.64 10.1 1.7 2.1 1 1 0 1 1 1 0 Glioma tumor suppressor candidate region Utp8 PF10395.4 AMD19844.1 - 5e-204 679.4 22.9 5.6e-204 679.2 15.9 1.0 1 0 0 1 1 1 1 Utp8 family DUF573 PF04504.9 AMD19844.1 - 0.00093 19.4 3.3 0.027 14.7 0.3 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF573 DUF4163 PF13739.1 AMD19844.1 - 0.35 11.6 3.3 5.4 7.8 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4163) DUF2305 PF10230.4 AMD19845.1 - 5e-68 229.4 0.3 5.7e-68 229.2 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Ser_hydrolase PF06821.8 AMD19845.1 - 0.0027 17.3 0.0 0.063 12.8 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_6 PF12697.2 AMD19845.1 - 0.0096 15.8 0.0 0.03 14.1 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 AMD19845.1 - 0.013 15.0 2.4 0.13 11.8 1.6 2.5 1 1 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.2 AMD19845.1 - 0.037 13.7 0.0 0.056 13.2 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 AMD19845.1 - 0.049 12.8 0.0 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family PUF PF00806.14 AMD19845.1 - 0.081 12.4 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat NRDE PF05742.7 AMD19846.1 - 1.2e-48 165.8 0.0 1.5e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 NRDE protein Sulfate_transp PF00916.15 AMD19847.1 - 1e-48 165.7 0.6 1e-48 165.7 0.4 1.7 2 0 0 2 2 2 1 Sulfate transporter family STAS PF01740.16 AMD19847.1 - 1.2e-12 47.3 0.5 2e-12 46.5 0.3 1.4 1 0 0 1 1 1 1 STAS domain cNMP_binding PF00027.24 AMD19847.1 - 0.002 17.8 0.0 0.0061 16.3 0.0 1.8 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Pkinase PF00069.20 AMD19848.1 - 3.7e-52 177.0 0.0 3e-51 174.0 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19848.1 - 1.5e-22 79.9 0.0 7.2e-19 67.8 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 AMD19848.1 - 0.058 12.3 0.4 0.45 9.4 0.1 2.4 2 1 0 2 2 2 0 Kinase-like DEAD PF00270.24 AMD19849.1 - 1.2e-45 155.0 0.8 5.4e-45 152.9 0.1 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19849.1 - 2.6e-22 78.4 0.0 6.1e-22 77.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 AMD19849.1 - 3.5e-19 68.0 0.2 7e-19 67.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) SecA_DEAD PF07517.9 AMD19849.1 - 0.0018 17.5 0.0 0.006 15.9 0.0 1.6 1 1 0 1 1 1 1 SecA DEAD-like domain ResIII PF04851.10 AMD19849.1 - 0.002 17.9 0.1 0.0047 16.7 0.1 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 AMD19849.1 - 0.047 13.8 1.1 0.28 11.3 0.7 2.4 2 1 0 2 2 2 0 AAA domain FLO_LFY PF01698.11 AMD19849.1 - 0.12 11.1 0.2 0.35 9.6 0.0 1.7 2 0 0 2 2 2 0 Floricaula / Leafy protein tRNA-synt_1g PF09334.6 AMD19850.1 - 6.1e-145 482.7 0.0 7.9e-145 482.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.5 AMD19850.1 - 8.8e-36 122.9 0.2 1.7e-35 122.0 0.1 1.5 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1 PF00133.17 AMD19850.1 - 4.6e-10 38.1 1.0 0.0003 18.9 0.0 3.4 2 2 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 AMD19850.1 - 0.051 13.3 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Kdo PF06293.9 AMD19851.1 - 2e-08 33.5 0.0 2.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD19851.1 - 1.6e-05 24.7 0.0 0.0013 18.5 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 AMD19851.1 - 7.3e-05 22.0 0.0 9.4e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD19851.1 - 0.045 12.8 0.0 0.056 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase EcKinase PF02958.15 AMD19851.1 - 0.057 12.5 0.0 0.081 12.0 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase DUF1679 PF07914.6 AMD19851.1 - 0.13 10.8 0.0 0.24 9.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Aminotran_4 PF01063.14 AMD19852.1 - 1.5e-19 70.3 0.0 2.7e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class IV Erv26 PF04148.8 AMD19853.1 - 6.6e-77 257.6 8.3 7.7e-77 257.4 5.7 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF996 PF06195.8 AMD19853.1 - 0.028 14.3 1.9 0.079 12.9 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF996) 6PGD PF00393.14 AMD19855.1 - 9.8e-131 435.2 0.0 1.2e-130 434.9 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 AMD19855.1 - 1.5e-52 177.7 0.0 2.2e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 AMD19855.1 - 0.0042 17.4 0.2 0.0079 16.6 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 AMD19855.1 - 0.0097 15.0 0.0 0.023 13.8 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_11 PF14833.1 AMD19855.1 - 0.018 15.1 0.1 0.13 12.2 0.0 2.4 3 0 0 3 3 3 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Mito_carr PF00153.22 AMD19857.1 - 2e-64 213.3 0.0 4e-24 84.1 0.0 3.6 2 1 1 3 3 3 3 Mitochondrial carrier protein XPG_N PF00752.12 AMD19859.1 - 3.9e-34 116.9 0.0 8.7e-34 115.8 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 AMD19859.1 - 1.2e-25 89.3 0.0 3.4e-25 87.9 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.2 AMD19859.1 - 4e-05 23.2 0.1 0.00014 21.4 0.0 1.9 1 1 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.15 AMD19859.1 - 0.00018 21.7 0.2 0.00056 20.0 0.0 2.0 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.11 AMD19859.1 - 0.017 15.2 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family Fasciclin PF02469.17 AMD19860.1 - 1.4e-07 31.5 0.0 3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Fasciclin domain HLH PF00010.21 AMD19861.1 - 1.5e-19 69.4 2.6 3.2e-19 68.3 0.7 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain XPG_N PF00752.12 AMD19862.1 - 6.1e-24 84.2 0.0 1.6e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 AMD19862.1 - 7.9e-23 80.3 0.0 1.8e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 XPG I-region HHH_2 PF12826.2 AMD19862.1 - 0.032 14.1 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix motif 5_3_exonuc PF01367.15 AMD19862.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Ank_2 PF12796.2 AMD19863.1 - 2.8e-49 165.3 0.6 3.4e-17 62.5 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 AMD19863.1 - 6.9e-37 123.4 1.3 3.2e-08 32.9 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.1 AMD19863.1 - 7.5e-29 96.9 0.4 2.3e-06 27.2 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 AMD19863.1 - 4e-28 96.8 0.1 1.5e-09 37.7 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 AMD19863.1 - 2.3e-26 91.6 2.4 9.4e-08 32.3 0.0 5.6 3 2 2 5 5 5 4 Ankyrin repeats (many copies) zf-DHHC PF01529.15 AMD19863.1 - 2.7e-22 78.9 2.8 2.7e-22 78.9 2.0 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase UNC45-central PF11701.3 AMD19864.1 - 7.6e-23 80.9 0.8 7.6e-23 80.9 0.5 3.2 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central Pex2_Pex12 PF04757.9 AMD19865.1 - 1.3e-29 103.3 6.2 1.8e-29 102.7 4.3 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.1 AMD19865.1 - 9.9e-09 34.8 18.6 1.5e-08 34.3 12.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 AMD19865.1 - 2.7e-07 30.5 18.9 4.4e-07 29.8 13.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD19865.1 - 3.6e-06 26.5 19.3 5.1e-06 26.0 13.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD19865.1 - 2.5e-05 23.8 17.0 4e-05 23.1 11.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD19865.1 - 0.00011 21.8 14.4 0.00019 21.0 10.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 AMD19865.1 - 0.0054 16.8 15.5 0.012 15.6 10.7 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_4 PF15227.1 AMD19865.1 - 0.017 14.9 17.7 0.032 14.1 12.3 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 AMD19865.1 - 0.034 13.9 10.2 0.056 13.2 7.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger ABA_GPCR PF12430.3 AMD19865.1 - 0.11 11.6 1.2 0.14 11.3 0.2 1.5 2 0 0 2 2 2 0 Abscisic acid G-protein coupled receptor zf-RING_UBOX PF13445.1 AMD19865.1 - 0.24 11.1 12.4 0.06 13.0 4.8 2.4 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.1 AMD19866.1 - 1.9e-06 27.4 6.4 1.9e-06 27.4 4.4 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) PAH PF02671.16 AMD19866.1 - 0.0031 17.0 2.2 0.05 13.2 0.1 2.8 2 0 0 2 2 2 1 Paired amphipathic helix repeat zf-RING_5 PF14634.1 AMD19866.1 - 0.0076 15.9 9.1 0.0076 15.9 6.3 3.4 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 AMD19866.1 - 0.0087 16.0 8.2 0.0087 16.0 5.6 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) ApoL PF05461.6 AMD19866.1 - 0.069 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein L PGP_phosphatase PF09419.5 AMD19867.1 - 8e-68 227.0 0.0 9.2e-68 226.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 AMD19867.1 - 3.9e-05 23.2 0.0 5.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 AMD19867.1 - 0.026 14.9 0.0 0.05 14.0 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF3329 PF11808.3 AMD19868.1 - 0.46 10.6 0.1 0.46 10.6 0.1 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF3329) FAT PF02259.18 AMD19869.1 - 1.3e-70 238.1 11.4 1.5e-70 237.9 5.8 2.2 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.22 AMD19869.1 - 1.4e-42 145.8 4.2 3.6e-42 144.4 0.8 3.2 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 AMD19869.1 - 1.9e-07 30.4 0.1 6.1e-07 28.7 0.0 2.0 1 0 0 1 1 1 1 FATC domain TPR_11 PF13414.1 AMD19869.1 - 0.014 15.0 5.5 0.079 12.6 0.2 3.5 4 1 0 4 4 4 0 TPR repeat EMP24_GP25L PF01105.19 AMD19870.1 - 2.1e-39 135.1 0.1 2.4e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Metallophos PF00149.23 AMD19871.1 - 3.6e-44 150.5 0.1 4.4e-44 150.2 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Yip1 PF04893.12 AMD19872.1 - 6.8e-09 35.4 9.5 9.4e-09 34.9 6.6 1.2 1 0 0 1 1 1 1 Yip1 domain Kelch_6 PF13964.1 AMD19873.1 - 7.7e-19 67.0 2.7 1.7e-06 27.9 0.0 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 AMD19873.1 - 9.6e-17 60.5 3.3 0.0022 17.7 0.0 5.7 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.20 AMD19873.1 - 2.4e-13 49.4 4.7 0.00026 20.4 0.0 5.0 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 AMD19873.1 - 4.5e-11 42.5 1.5 0.12 12.5 0.0 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 AMD19873.1 - 0.00029 20.4 2.0 0.072 12.8 0.0 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.1 AMD19873.1 - 0.0007 19.4 2.0 3 7.9 0.0 4.3 4 0 0 4 4 4 2 Kelch motif DUF3554 PF12074.3 AMD19874.1 - 7.4e-46 157.1 20.5 9.1e-27 94.3 2.0 6.8 6 1 1 7 7 7 3 Domain of unknown function (DUF3554) HEAT_2 PF13646.1 AMD19874.1 - 3.4e-39 132.9 26.1 5.3e-10 39.4 0.0 15.2 10 3 7 17 17 17 7 HEAT repeats HEAT_EZ PF13513.1 AMD19874.1 - 1.1e-30 105.2 28.6 0.0024 18.2 2.0 19.5 15 5 6 21 21 21 10 HEAT-like repeat HEAT PF02985.17 AMD19874.1 - 2e-23 80.3 33.5 0.00093 19.0 0.0 18.9 24 0 0 24 24 24 6 HEAT repeat Vac14_Fab1_bd PF12755.2 AMD19874.1 - 9.5e-16 57.9 0.1 0.0067 16.7 0.0 10.3 8 1 0 9 9 9 2 Vacuolar 14 Fab1-binding region Ipi1_N PF12333.3 AMD19874.1 - 0.00031 20.6 5.4 1.3 9.0 0.0 7.3 8 2 0 8 8 8 1 Rix1 complex component involved in 60S ribosome maturation Hist_deacetyl PF00850.14 AMD19876.1 - 5.2e-81 272.3 0.0 6.8e-81 271.9 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain MT-A70 PF05063.9 AMD19877.1 - 1.4e-53 181.0 0.2 1.4e-53 181.0 0.1 1.6 2 0 0 2 2 2 1 MT-A70 DUF2453 PF10507.4 AMD19878.1 - 0.039 13.7 0.2 0.09 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2453) ATP_synt_H PF05493.8 AMD19879.1 - 3.3e-22 78.3 3.6 3.7e-22 78.1 2.5 1.0 1 0 0 1 1 1 1 ATP synthase subunit H MgtE PF01769.11 AMD19879.1 - 0.0081 16.4 1.2 0.0087 16.3 0.9 1.0 1 0 0 1 1 1 1 Divalent cation transporter 7TM-7TMR_HD PF07698.6 AMD19879.1 - 0.013 14.9 2.7 0.015 14.7 1.9 1.0 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF3624 PF12292.3 AMD19879.1 - 0.092 13.1 3.6 0.17 12.3 2.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3624) GWT1 PF06423.7 AMD19879.1 - 0.16 12.0 1.4 0.18 11.9 1.0 1.1 1 0 0 1 1 1 0 GWT1 BPD_transp_1 PF00528.17 AMD19879.1 - 0.35 10.3 3.6 0.35 10.3 2.5 1.0 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component DUF788 PF05620.6 AMD19879.1 - 1.5 8.6 4.0 1.7 8.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF788) UEV PF05743.8 AMD19880.1 - 7.2e-24 83.7 0.0 1.6e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.5 AMD19880.1 - 2.7e-22 78.1 2.0 5.6e-22 77.1 0.3 2.3 2 0 0 2 2 2 1 Vps23 core domain Med11 PF10280.4 AMD19880.1 - 0.015 15.3 2.3 1.2 9.2 1.6 2.3 1 1 0 1 1 1 0 Mediator complex protein End3 PF12761.2 AMD19880.1 - 0.066 12.8 2.3 0.12 12.0 1.6 1.3 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 UQ_con PF00179.21 AMD19880.1 - 0.077 12.4 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Clr5 PF14420.1 AMD19880.1 - 0.15 12.0 0.0 9.9 6.1 0.0 2.6 2 1 0 2 2 2 0 Clr5 domain AMPKBI PF04739.10 AMD19880.1 - 2.8 7.8 6.0 30 4.5 4.2 2.4 1 1 0 1 1 1 0 5'-AMP-activated protein kinase beta subunit, interation domain DKCLD PF08068.7 AMD19881.1 - 1.9e-29 101.3 0.2 7.2e-29 99.4 0.1 2.0 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 AMD19881.1 - 9.9e-22 77.6 5.2 4.4e-20 72.3 0.0 3.8 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 AMD19881.1 - 1.3e-20 72.8 1.0 3.3e-20 71.5 0.7 1.7 1 0 0 1 1 1 1 PUA domain GAGA_bind PF06217.7 AMD19881.1 - 0.0067 16.4 20.6 0.009 16.0 14.3 1.2 1 0 0 1 1 1 1 GAGA binding protein-like family FLO_LFY PF01698.11 AMD19881.1 - 7.1 5.3 22.6 10 4.8 15.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein CTDII PF01556.13 AMD19882.1 - 4.7e-25 87.3 0.2 3.6e-21 74.8 0.0 2.7 2 1 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 AMD19882.1 - 8.2e-24 83.1 0.3 1.3e-23 82.5 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain ABC_tran PF00005.22 AMD19883.1 - 3.2e-47 160.2 0.1 3e-22 79.3 0.0 3.1 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 AMD19883.1 - 2.5e-20 73.6 15.9 1e-08 35.4 0.2 5.2 4 2 1 5 5 5 3 AAA domain ABC_tran_2 PF12848.2 AMD19883.1 - 4.9e-19 67.9 8.3 4.9e-19 67.9 5.8 3.2 4 0 0 4 4 1 1 ABC transporter SMC_N PF02463.14 AMD19883.1 - 5.9e-12 45.2 0.0 2.3e-05 23.7 0.0 3.8 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 AMD19883.1 - 2.5e-10 41.2 3.0 0.00024 21.8 0.0 3.6 4 1 0 4 4 2 2 AAA domain AAA_16 PF13191.1 AMD19883.1 - 5.6e-08 32.9 0.0 0.014 15.3 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.1 AMD19883.1 - 1.3e-07 31.7 0.0 0.012 15.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 AMD19883.1 - 3.1e-07 30.1 0.0 0.0031 17.1 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.1 AMD19883.1 - 4.5e-07 30.0 0.0 0.052 13.6 0.0 3.2 2 1 0 2 2 2 2 AAA domain Miro PF08477.8 AMD19883.1 - 4.7e-07 30.3 0.0 0.044 14.2 0.0 3.0 2 1 0 2 2 2 2 Miro-like protein DUF258 PF03193.11 AMD19883.1 - 1.2e-06 27.7 0.0 0.033 13.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_29 PF13555.1 AMD19883.1 - 1.2e-06 27.9 0.1 0.07 12.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_14 PF13173.1 AMD19883.1 - 2.2e-06 27.5 0.0 0.068 13.0 0.0 3.4 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 AMD19883.1 - 3.1e-06 27.1 0.0 0.071 13.0 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA PF00004.24 AMD19883.1 - 7.3e-06 26.2 0.1 0.03 14.5 0.0 4.1 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 AMD19883.1 - 8.8e-06 26.1 29.0 0.11 12.8 0.0 5.3 5 0 0 5 5 5 2 AAA domain AAA_18 PF13238.1 AMD19883.1 - 1.8e-05 25.0 11.6 0.013 15.7 0.0 4.1 4 3 0 4 4 3 2 AAA domain AAA_33 PF13671.1 AMD19883.1 - 2e-05 24.4 0.3 0.027 14.3 0.0 3.2 3 1 0 3 3 2 1 AAA domain MobB PF03205.9 AMD19883.1 - 2.2e-05 24.1 0.2 0.19 11.4 0.0 3.1 3 0 0 3 3 2 2 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_ab PF00006.20 AMD19883.1 - 2.3e-05 24.0 0.0 0.02 14.4 0.0 2.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.1 AMD19883.1 - 4.7e-05 22.6 26.3 0.026 13.5 0.8 5.9 3 2 2 6 6 5 3 AAA ATPase domain PduV-EutP PF10662.4 AMD19883.1 - 6.3e-05 22.4 0.0 0.062 12.7 0.0 2.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 AMD19883.1 - 9.4e-05 22.5 0.5 0.24 11.5 0.0 3.5 4 0 0 4 4 2 1 RNA helicase NB-ARC PF00931.17 AMD19883.1 - 0.00032 19.6 0.2 0.91 8.3 0.0 2.8 2 1 1 3 3 3 2 NB-ARC domain NTPase_1 PF03266.10 AMD19883.1 - 0.00033 20.3 0.0 0.29 10.8 0.0 2.7 2 0 0 2 2 2 1 NTPase AAA_10 PF12846.2 AMD19883.1 - 0.00039 19.9 0.9 1.7 8.0 0.0 3.6 2 2 0 3 3 3 1 AAA-like domain SbcCD_C PF13558.1 AMD19883.1 - 0.00039 20.2 0.1 1.7 8.6 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 AMD19883.1 - 0.00058 19.3 0.0 1.1 8.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain ArgK PF03308.11 AMD19883.1 - 0.0012 17.6 0.8 0.3 9.8 0.0 3.0 3 0 0 3 3 3 1 ArgK protein cobW PF02492.14 AMD19883.1 - 0.0014 18.0 0.6 0.84 9.0 0.0 2.9 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain Pox_A32 PF04665.7 AMD19883.1 - 0.0021 17.3 0.0 0.075 12.3 0.0 2.5 2 0 0 2 2 2 1 Poxvirus A32 protein T2SE PF00437.15 AMD19883.1 - 0.0025 16.7 0.0 0.051 12.4 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_5 PF07728.9 AMD19883.1 - 0.0029 17.3 0.1 1.4 8.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Septin PF00735.13 AMD19883.1 - 0.0032 16.5 0.9 1.9 7.4 0.3 3.0 2 1 0 2 2 2 1 Septin AAA_30 PF13604.1 AMD19883.1 - 0.0037 16.8 0.0 0.66 9.5 0.0 3.5 4 0 0 4 4 3 1 AAA domain Ras PF00071.17 AMD19883.1 - 0.0063 15.9 1.0 5.4 6.3 0.0 3.4 3 0 0 3 3 3 0 Ras family FtsK_SpoIIIE PF01580.13 AMD19883.1 - 0.0065 15.9 0.0 1.6 8.1 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family Seryl_tRNA_N PF02403.17 AMD19883.1 - 0.014 15.3 6.9 0.014 15.3 4.8 4.2 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain SRP54 PF00448.17 AMD19883.1 - 0.014 14.8 0.3 0.96 8.8 0.0 3.2 4 0 0 4 4 2 0 SRP54-type protein, GTPase domain AAA_24 PF13479.1 AMD19883.1 - 0.014 14.9 0.0 6.6 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.13 AMD19883.1 - 0.02 14.1 0.0 2.9 7.1 0.0 2.7 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF2813 PF11398.3 AMD19883.1 - 0.024 13.7 7.7 0.35 9.8 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF2813) Viral_helicase1 PF01443.13 AMD19883.1 - 0.024 14.1 0.0 0.78 9.2 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Dynamin_N PF00350.18 AMD19883.1 - 0.026 14.3 10.5 0.052 13.3 0.5 3.7 3 1 1 4 4 3 0 Dynamin family Arch_ATPase PF01637.13 AMD19883.1 - 0.052 13.2 13.7 0.18 11.4 0.0 3.8 4 0 0 4 4 4 0 Archaeal ATPase DUF87 PF01935.12 AMD19883.1 - 0.4 10.4 16.7 0.6 9.8 0.0 4.8 4 1 1 5 5 5 0 Domain of unknown function DUF87 IncA PF04156.9 AMD19883.1 - 9.5 5.7 17.9 0.063 12.8 4.4 2.7 3 0 0 3 3 2 0 IncA protein RNB PF00773.14 AMD19884.1 - 1.6e-95 320.0 0.1 2.6e-95 319.4 0.0 1.3 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 AMD19884.1 - 3.2e-13 49.9 0.3 8.1e-13 48.6 0.2 1.7 1 0 0 1 1 1 1 PIN domain OB_RNB PF08206.6 AMD19884.1 - 0.083 12.4 0.0 0.26 10.8 0.0 1.8 1 0 0 1 1 1 0 Ribonuclease B OB domain AA_permease PF00324.16 AMD19885.1 - 1.8e-121 405.7 42.9 2.3e-121 405.4 29.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD19885.1 - 5.2e-30 104.3 43.0 6.3e-30 104.0 29.8 1.1 1 0 0 1 1 1 1 Amino acid permease UCH PF00443.24 AMD19886.1 - 1.2e-53 181.9 1.0 1.5e-53 181.6 0.7 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD19886.1 - 2.6e-15 56.6 5.1 6.5e-15 55.3 3.5 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 AMD19886.1 - 1.7e-05 24.1 0.1 7.2e-05 22.1 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family DUF2267 PF10025.4 AMD19886.1 - 0.0034 17.4 0.8 0.43 10.6 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2267) DUF1690 PF07956.6 AMD19887.1 - 1.2e-39 135.5 9.9 1.3e-39 135.3 6.8 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) DUF2207 PF09972.4 AMD19887.1 - 0.3 9.6 4.6 0.41 9.1 2.9 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) hDGE_amylase PF14701.1 AMD19887.1 - 0.98 8.2 4.9 1.2 7.9 3.4 1.0 1 0 0 1 1 1 0 glucanotransferase domain of human glycogen debranching enzyme FlaC_arch PF05377.6 AMD19888.1 - 0.71 9.8 4.8 0.45 10.4 0.2 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.10 AMD19888.1 - 1.1 8.8 6.7 0.55 9.7 0.8 3.0 3 0 0 3 3 3 0 Septum formation initiator Prefoldin_2 PF01920.15 AMD19888.1 - 9.8 5.9 11.2 2.4 7.9 0.1 3.8 3 1 0 3 3 3 0 Prefoldin subunit SEN1_N PF12726.2 AMD19889.1 - 7.5e-208 692.0 14.5 7.5e-208 692.0 10.0 1.7 2 0 0 2 2 2 1 SEN1 N terminal AAA_11 PF13086.1 AMD19889.1 - 8.5e-68 228.4 1.0 8.5e-68 228.4 0.7 2.1 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 AMD19889.1 - 1.7e-63 213.6 0.1 8.8e-63 211.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 AMD19889.1 - 5.4e-11 42.0 0.0 1.2e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 AMD19889.1 - 2.3e-08 33.8 0.0 3.9e-05 23.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 AMD19889.1 - 1.5e-05 24.6 0.0 0.67 9.4 0.0 3.8 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 AMD19889.1 - 0.002 18.2 0.0 0.013 15.5 0.0 2.4 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_25 PF13481.1 AMD19889.1 - 0.0098 15.3 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF1900 PF08954.6 AMD19890.1 - 2.6e-50 169.4 0.1 3.6e-49 165.7 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 AMD19890.1 - 7.6e-32 108.7 0.2 1.4e-31 107.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.27 AMD19890.1 - 5.6e-24 83.0 8.2 2e-07 30.6 0.1 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.3 AMD19890.1 - 9.5e-07 27.3 0.3 0.0067 14.6 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 HPS3_N PF14761.1 AMD19890.1 - 0.095 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 zf-C3HC4_2 PF13923.1 AMD19891.1 - 9.5e-08 31.9 3.1 2.8e-07 30.4 2.2 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD19891.1 - 2e-07 30.5 3.1 7.7e-07 28.6 2.2 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD19891.1 - 3.3e-06 26.8 5.1 5.9e-06 26.0 3.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 AMD19891.1 - 1.6e-05 24.4 4.2 3.3e-05 23.4 2.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 AMD19891.1 - 2e-05 24.3 4.2 2e-05 24.3 2.9 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 AMD19891.1 - 8.7e-05 22.1 4.7 0.0002 20.9 3.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 AMD19891.1 - 0.00012 21.7 3.0 0.00041 20.0 2.1 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 AMD19891.1 - 0.17 12.0 1.1 0.49 10.5 0.7 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger zf-MIZ PF02891.15 AMD19891.1 - 2.2 7.8 6.1 3.7 7.1 1.4 2.3 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger SPC25 PF06703.6 AMD19892.1 - 4.6e-37 127.0 0.3 5.3e-37 126.8 0.2 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) adh_short PF00106.20 AMD19893.1 - 1.9e-20 73.4 0.0 6.8e-20 71.6 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AMD19893.1 - 4.7e-08 32.9 0.0 5.3e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 AMD19893.1 - 1.2e-06 28.5 0.0 1.5e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 AMD19893.1 - 0.0009 18.7 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 AMD19893.1 - 0.022 13.7 0.1 4.3 6.1 0.0 2.3 1 1 1 2 2 2 0 Male sterility protein CNH PF00780.17 AMD19894.1 - 3.1e-20 72.7 0.2 2.5e-19 69.7 0.1 2.2 1 1 0 1 1 1 1 CNH domain RhoGEF PF00621.15 AMD19894.1 - 2e-08 34.3 0.0 5.6e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.24 AMD19894.1 - 5.2e-08 33.0 1.6 1.1e-07 32.0 0.0 2.5 3 0 0 3 3 3 1 PH domain PH_5 PF15405.1 AMD19894.1 - 3.9e-07 30.0 0.1 9.8e-07 28.7 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Synaptobrevin PF00957.16 AMD19895.1 - 3.7e-15 55.3 0.7 5.7e-15 54.6 0.5 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 AMD19895.1 - 6.8e-15 54.3 0.0 1.1e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain CHCH PF06747.8 AMD19896.1 - 2.5e-08 33.6 2.7 4.2e-08 32.8 1.8 1.4 1 0 0 1 1 1 1 CHCH domain G-patch PF01585.18 AMD19897.1 - 1.5e-14 53.5 3.8 6.9e-13 48.1 2.0 2.3 2 0 0 2 2 2 2 G-patch domain G-patch_2 PF12656.2 AMD19897.1 - 6.5e-08 32.3 0.1 1.3e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 DExH-box splicing factor binding site APG17 PF04108.7 AMD19898.1 - 2.4e-96 323.0 19.0 2.7e-96 322.8 13.2 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Herpes_UL36 PF03586.8 AMD19898.1 - 0.0049 15.9 1.4 0.013 14.5 0.2 2.0 2 0 0 2 2 2 1 Herpesvirus UL36 tegument protein BicD PF09730.4 AMD19898.1 - 0.09 11.1 19.4 0.0055 15.1 4.6 2.2 1 1 1 2 2 2 0 Microtubule-associated protein Bicaudal-D DUF1925 PF09094.6 AMD19898.1 - 0.17 11.8 1.0 5 7.1 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1925) Fes1 PF08609.5 AMD19898.1 - 0.6 10.6 4.7 0.41 11.1 0.3 2.8 3 2 0 3 3 3 0 Nucleotide exchange factor Fes1 DUF1415 PF07209.7 AMD19898.1 - 0.75 9.5 6.1 0.94 9.1 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1415) Plasmodium_Vir PF05795.6 AMD19898.1 - 0.95 8.5 9.0 0.072 12.2 2.6 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein RuvC PF02075.12 AMD19898.1 - 2.1 8.1 5.1 3.3 7.5 0.1 3.1 4 0 0 4 4 4 0 Crossover junction endodeoxyribonuclease RuvC MCPsignal PF00015.16 AMD19898.1 - 2.2 7.7 7.4 3.2 7.2 0.5 2.8 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain RhoGEF PF00621.15 AMD19898.1 - 2.5 7.9 16.6 3.9 7.2 6.2 3.2 2 2 0 2 2 2 0 RhoGEF domain tRNA-synt_2b PF00587.20 AMD19899.1 - 1.6e-47 161.3 0.1 4.4e-47 159.8 0.1 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AMD19899.1 - 1.1e-17 63.6 0.1 2.4e-17 62.6 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain LRR_4 PF12799.2 AMD19900.1 - 1.6e-43 145.6 44.5 1.9e-09 36.8 3.1 6.9 3 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 AMD19900.1 - 4.9e-37 125.4 66.4 5e-10 38.9 0.9 6.3 2 1 5 7 7 7 6 Leucine rich repeat LRR_1 PF00560.28 AMD19900.1 - 7.7e-16 55.6 40.1 0.026 14.4 0.1 11.8 13 0 0 13 13 13 6 Leucine Rich Repeat LRR_6 PF13516.1 AMD19900.1 - 5.7e-14 50.5 27.8 0.0019 18.0 0.1 11.1 8 3 2 10 10 10 4 Leucine Rich repeat LRR_7 PF13504.1 AMD19900.1 - 7.4e-13 46.4 14.9 0.88 10.0 0.0 10.1 7 2 2 9 9 9 4 Leucine rich repeat LRR_9 PF14580.1 AMD19900.1 - 5e-12 45.7 13.4 2.3e-06 27.2 1.8 3.4 1 1 2 3 3 3 3 Leucine-rich repeat DUF3744 PF12558.3 AMD19900.1 - 0.18 12.3 16.2 2.7 8.5 0.5 4.4 3 2 1 4 4 4 0 ATP-binding cassette cobalt transporter LRR_2 PF07723.8 AMD19900.1 - 1.8 9.2 9.2 59 4.3 0.4 5.3 5 0 0 5 5 5 0 Leucine Rich Repeat PP-binding PF00550.20 AMD19901.1 - 2.8e-11 43.4 0.8 3.8e-11 43.0 0.5 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 AMD19901.1 - 3.2e-06 27.0 0.9 4.8e-06 26.5 0.7 1.3 1 1 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.7 AMD19901.1 - 0.00012 22.1 0.3 0.00018 21.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1493) Ded_cyto PF06920.8 AMD19902.1 - 1.9e-22 79.4 0.0 5e-22 78.0 0.0 1.7 1 0 0 1 1 1 1 Dedicator of cytokinesis CinA PF02464.12 AMD19903.1 - 2.3e-30 105.0 0.0 2.7e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 Competence-damaged protein Proteasom_Rpn13 PF04683.8 AMD19904.1 - 1.2e-22 79.7 0.0 1.8e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Amidohydro_4 PF13147.1 AMD19905.1 - 2.1e-10 41.1 0.0 2.5e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_2 PF04909.9 AMD19905.1 - 1e-05 25.2 0.1 2.5e-05 23.9 0.1 1.9 1 1 0 1 1 1 1 Amidohydrolase Diphthamide_syn PF01866.12 AMD19906.1 - 2.5e-41 141.9 0.5 1.9e-22 79.8 0.0 2.2 2 0 0 2 2 2 2 Putative diphthamide synthesis protein CRAL_TRIO PF00650.15 AMD19907.1 - 1.9e-45 154.2 0.0 3.7e-45 153.2 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 AMD19907.1 - 4.4e-15 55.5 0.7 1.3e-14 54.0 0.5 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 AMD19907.1 - 3.9e-11 43.0 0.0 9.3e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain tRNA-synt_1 PF00133.17 AMD19909.1 - 6.5e-55 186.2 0.3 1.7e-18 65.9 0.5 6.0 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 AMD19909.1 - 2.7e-42 144.1 0.0 5.2e-42 143.2 0.0 1.5 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 AMD19909.1 - 7.3e-30 103.9 0.1 4e-22 78.4 0.0 4.5 3 1 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 AMD19909.1 - 3.2e-08 33.4 0.0 7.3e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1d PF00750.14 AMD19909.1 - 9.6e-05 21.3 0.0 0.00016 20.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) tRNA-synt_1e PF01406.14 AMD19909.1 - 0.00027 20.1 0.0 0.047 12.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain DNA_ligase_ZBD PF03119.11 AMD19909.1 - 0.002 17.7 0.0 0.018 14.7 0.0 2.4 2 0 0 2 2 2 1 NAD-dependent DNA ligase C4 zinc finger domain tRNA-synt_1c PF00749.16 AMD19909.1 - 0.026 13.2 0.4 2.7 6.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain SMC_N PF02463.14 AMD19910.1 - 7.9e-29 100.4 3.0 1.8e-15 56.7 0.1 2.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 AMD19910.1 - 3.1e-17 63.5 7.4 3.1e-17 63.5 5.2 4.9 2 2 2 4 4 1 1 AAA domain AAA_13 PF13166.1 AMD19910.1 - 3.6e-05 22.4 75.2 0.024 13.1 17.4 5.2 3 2 2 5 5 5 4 AAA domain CENP-F_leu_zip PF10473.4 AMD19910.1 - 0.00015 21.6 5.5 0.00015 21.6 3.8 5.6 3 2 2 6 6 5 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_29 PF13555.1 AMD19910.1 - 0.00021 20.7 0.0 0.00042 19.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 AMD19910.1 - 0.00024 20.2 32.1 0.00024 20.2 22.2 2.9 2 2 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.1 AMD19910.1 - 0.0054 16.7 27.1 0.1 12.5 0.7 4.4 1 1 1 3 3 3 2 AAA domain SbcCD_C PF13558.1 AMD19910.1 - 0.0073 16.1 0.0 0.03 14.2 0.0 2.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.22 AMD19910.1 - 0.17 12.1 0.1 0.17 12.1 0.1 5.5 3 2 0 3 3 2 0 ABC transporter Reo_sigmaC PF04582.7 AMD19910.1 - 0.45 9.6 14.8 0.58 9.2 0.2 3.7 2 2 1 4 4 4 0 Reovirus sigma C capsid protein Atg14 PF10186.4 AMD19910.1 - 5 5.9 71.4 0.038 12.9 8.4 5.2 2 2 3 5 5 5 0 UV radiation resistance protein and autophagy-related subunit 14 MAD PF05557.8 AMD19910.1 - 5.6 4.9 73.7 0.36 8.8 24.6 2.7 2 1 1 3 3 3 0 Mitotic checkpoint protein IncA PF04156.9 AMD19910.1 - 8.5 5.9 83.4 0.38 10.3 2.4 6.5 2 2 3 5 5 5 0 IncA protein Uso1_p115_head PF04869.9 AMD19911.1 - 1.6e-89 299.7 1.8 1.6e-89 299.7 1.2 3.5 4 0 0 4 4 4 1 Uso1 / p115 like vesicle tethering protein, head region Myosin_tail_1 PF01576.14 AMD19911.1 - 2e-09 35.8 61.5 2e-09 35.8 42.6 4.1 1 1 3 4 4 4 2 Myosin tail IncA PF04156.9 AMD19911.1 - 2.8e-05 23.7 132.1 0.0058 16.2 17.3 8.0 1 1 5 6 6 5 3 IncA protein DUF869 PF05911.6 AMD19911.1 - 6.1e-05 21.4 14.7 6.1e-05 21.4 10.2 4.4 1 1 3 4 4 3 2 Plant protein of unknown function (DUF869) DUF4201 PF13870.1 AMD19911.1 - 6.1e-05 22.5 17.5 6.1e-05 22.5 12.1 7.7 2 1 3 6 6 6 3 Domain of unknown function (DUF4201) Tropomyosin_1 PF12718.2 AMD19911.1 - 0.00078 19.3 24.0 0.00078 19.3 16.6 8.4 1 1 8 9 9 8 2 Tropomyosin like Cortex-I_coil PF09304.5 AMD19911.1 - 0.0013 18.7 9.4 0.0013 18.7 6.5 9.5 2 2 8 10 10 7 2 Cortexillin I, coiled coil GAS PF13851.1 AMD19911.1 - 0.071 12.2 153.6 0.008 15.3 9.5 9.0 2 1 7 9 9 9 0 Growth-arrest specific micro-tubule binding FUSC PF04632.7 AMD19911.1 - 1.1 7.6 5.1 3.8 5.8 3.4 2.1 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF3584 PF12128.3 AMD19911.1 - 1.7 5.8 114.7 0.036 11.4 28.6 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) TBPIP PF07106.8 AMD19911.1 - 3.8 7.0 139.5 0.17 11.4 11.4 9.9 2 2 8 10 10 10 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CENP-F_leu_zip PF10473.4 AMD19911.1 - 4.9 7.0 154.0 0.29 11.0 18.2 8.3 2 2 5 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rad52_Rad22 PF04098.10 AMD19912.1 - 3.3e-36 124.3 0.1 4e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein IKI3 PF04762.7 AMD19913.1 - 0 1049.7 0.1 0 1049.4 0.0 1.1 1 0 0 1 1 1 1 IKI3 family Clathrin PF00637.15 AMD19913.1 - 0.0073 15.9 0.5 20 4.7 0.0 3.7 2 1 1 3 3 3 2 Region in Clathrin and VPS SNAP PF14938.1 AMD19913.1 - 1 8.4 5.8 1.1 8.2 0.2 2.8 3 0 0 3 3 3 0 Soluble NSF attachment protein, SNAP Vac14_Fig4_bd PF11916.3 AMD19915.1 - 4.2e-68 228.0 4.5 4.2e-68 228.0 3.1 2.3 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 AMD19915.1 - 1.2e-48 163.4 2.0 3.2e-39 133.2 0.2 4.3 4 0 0 4 4 4 3 Vacuolar 14 Fab1-binding region HEAT PF02985.17 AMD19915.1 - 3.5e-16 57.7 3.6 9.1e-05 22.2 0.0 7.7 6 1 1 7 7 7 4 HEAT repeat HEAT_2 PF13646.1 AMD19915.1 - 1.4e-11 44.4 0.1 0.0086 16.3 0.1 5.2 4 1 0 4 4 4 2 HEAT repeats MMS19_C PF12460.3 AMD19915.1 - 4.9e-09 35.4 9.8 0.06 12.0 1.3 4.7 4 1 0 4 4 4 4 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.1 AMD19915.1 - 4.8e-07 30.0 1.1 0.061 13.8 0.0 6.4 6 1 1 7 7 7 1 HEAT-like repeat Cnd1 PF12717.2 AMD19915.1 - 3.4e-06 27.0 10.9 0.17 11.6 0.8 4.7 4 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 AMD19915.1 - 3.2e-05 23.3 3.6 0.12 11.6 0.1 4.3 3 2 1 4 4 4 2 CLASP N terminal RasGEF_N_2 PF14663.1 AMD19915.1 - 9.1e-05 22.3 3.9 0.0013 18.6 0.1 3.6 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Arm PF00514.18 AMD19915.1 - 0.00042 20.0 0.7 1.2 9.0 0.0 4.4 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat DUF3730 PF12530.3 AMD19915.1 - 0.00074 19.4 3.7 0.0034 17.3 0.2 3.4 4 0 0 4 4 4 1 Protein of unknown function (DUF3730) DUF2806 PF10987.3 AMD19915.1 - 0.017 14.6 0.4 0.037 13.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2806) TIP120 PF08623.5 AMD19915.1 - 1.8 8.1 8.3 4.9 6.6 0.0 4.4 5 1 0 5 5 5 0 TATA-binding protein interacting (TIP20) zf-C2H2_2 PF12756.2 AMD19916.1 - 9.1e-31 105.9 3.9 1e-27 96.1 0.9 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 AMD19916.1 - 0.031 14.4 11.1 0.073 13.2 0.7 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 AMD19916.1 - 0.063 13.2 2.0 8 6.5 0.0 2.6 2 0 0 2 2 2 0 Zinc ribbon domain CCG PF02754.11 AMD19916.1 - 0.16 11.9 1.2 3.7 7.6 0.0 3.0 3 0 0 3 3 3 0 Cysteine-rich domain zf-C2H2_4 PF13894.1 AMD19916.1 - 8.8 6.9 13.8 29 5.3 0.1 4.3 4 1 0 4 4 4 0 C2H2-type zinc finger DUF663 PF04950.7 AMD19917.1 - 1.2e-91 306.8 0.0 1.9e-91 306.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 AMD19917.1 - 4.3e-23 80.6 0.0 9.8e-23 79.5 0.0 1.6 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Ribosomal_S14 PF00253.16 AMD19918.1 - 5.6e-19 67.2 3.4 6.2e-19 67.1 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF2296 PF10058.4 AMD19918.1 - 0.075 12.7 1.5 3.9 7.2 1.6 2.1 1 1 1 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Prim_Zn_Ribbon PF08273.7 AMD19918.1 - 0.1 12.7 1.8 2.4 8.3 0.1 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF4428 PF14471.1 AMD19918.1 - 0.12 12.1 0.4 0.15 11.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Peptidase_M16 PF00675.15 AMD19919.1 - 6.2e-36 123.3 0.3 4.7e-35 120.5 0.1 2.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 AMD19919.1 - 3.2e-24 85.5 0.1 3.4e-19 69.2 0.0 2.7 2 1 0 2 2 2 2 Peptidase M16 inactive domain UQ_con PF00179.21 AMD19922.1 - 3.4e-43 146.4 0.1 3.9e-43 146.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 AMD19922.1 - 2.2e-06 27.4 0.0 3.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 AMD19922.1 - 0.22 11.4 1.9 0.33 10.8 1.3 1.7 1 1 0 1 1 1 0 RWD domain Pex19 PF04614.7 AMD19923.1 - 5e-56 190.1 17.0 6.1e-56 189.8 11.8 1.2 1 0 0 1 1 1 1 Pex19 protein family XPC-binding PF09280.6 AMD19923.1 - 0.021 14.2 5.4 0.67 9.4 0.1 3.5 4 0 0 4 4 4 0 XPC-binding domain Penicillinase_R PF03965.11 AMD19923.1 - 0.037 14.1 0.4 0.071 13.2 0.3 1.6 1 0 0 1 1 1 0 Penicillinase repressor COG2 PF06148.6 AMD19923.1 - 0.056 13.3 2.3 1.3 8.8 0.0 2.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4239 PF14023.1 AMD19923.1 - 0.56 9.5 1.8 0.65 9.3 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) Med10 PF09748.4 AMD19923.1 - 1.3 8.8 5.5 4.1 7.2 0.2 2.8 2 1 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex GET2 PF08690.5 AMD19923.1 - 5.4 6.1 19.4 22 4.1 11.2 2.7 1 1 1 2 2 2 0 GET complex subunit GET2 CFEM PF05730.6 AMD19924.1 - 3.4e-08 33.1 9.0 5.5e-08 32.5 6.2 1.3 1 0 0 1 1 1 1 CFEM domain UCR_hinge PF02320.11 AMD19924.1 - 0.22 11.4 1.8 0.23 11.4 0.5 1.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein TFIIA PF03153.8 AMD19924.1 - 4.8 6.9 15.6 6.7 6.5 10.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arrestin_N PF00339.24 AMD19925.1 - 1.4e-06 28.2 0.0 1.6e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain ATP-synt_10 PF05176.9 AMD19926.1 - 5.7e-66 222.3 0.0 6.8e-66 222.1 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein A2M_N_2 PF07703.9 AMD19926.1 - 0.039 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Alpha-2-macroglobulin family N-terminal region Iso_dh PF00180.15 AMD19927.1 - 6.1e-68 229.3 0.0 7.2e-68 229.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DHFR_2 PF06442.6 AMD19927.1 - 0.041 13.5 0.0 4.9 6.8 0.0 2.4 2 0 0 2 2 2 0 R67 dihydrofolate reductase COX7C PF02935.11 AMD19928.1 - 1.6e-19 69.4 4.2 1.7e-19 69.3 2.9 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc COX6C PF02937.10 AMD19929.1 - 0.041 13.7 0.0 0.044 13.6 0.0 1.0 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc Sec1 PF00995.18 AMD19930.1 - 3.1e-64 217.6 12.2 7.3e-64 216.3 8.5 1.6 1 1 0 1 1 1 1 Sec1 family AAA PF00004.24 AMD19931.1 - 5.1e-88 292.0 0.0 1.1e-42 145.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD19931.1 - 1.1e-12 47.5 0.0 9.3e-06 24.8 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 AMD19931.1 - 1.7e-11 44.4 0.1 5.7e-06 26.4 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.9 AMD19931.1 - 2.2e-11 43.6 0.3 0.00018 21.2 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 AMD19931.1 - 3.2e-11 43.4 2.7 8.8e-05 22.6 0.1 4.3 2 2 0 2 2 2 2 AAA domain AAA_2 PF07724.9 AMD19931.1 - 2.4e-09 37.3 0.0 0.00052 19.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 AMD19931.1 - 4.1e-08 33.1 0.0 0.0046 16.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 AMD19931.1 - 5.2e-08 32.5 7.0 0.08 12.3 0.1 4.4 2 2 1 4 4 4 3 AAA domain AAA_33 PF13671.1 AMD19931.1 - 3.8e-07 30.0 0.0 0.00023 21.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain CDC48_N PF02359.13 AMD19931.1 - 4.4e-07 29.7 0.0 1.4e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_17 PF13207.1 AMD19931.1 - 4.2e-06 27.5 0.0 0.17 12.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AMD19931.1 - 5.5e-06 26.0 0.8 0.0053 16.4 0.0 3.3 3 0 0 3 3 3 1 Part of AAA domain RNA_helicase PF00910.17 AMD19931.1 - 7.2e-06 26.1 0.0 0.063 13.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.8 AMD19931.1 - 8.3e-06 24.7 0.0 0.027 13.2 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus NACHT PF05729.7 AMD19931.1 - 2.6e-05 23.9 0.6 0.038 13.6 0.0 3.9 4 0 0 4 4 4 1 NACHT domain AAA_28 PF13521.1 AMD19931.1 - 3.6e-05 23.7 0.0 0.17 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 AMD19931.1 - 4.1e-05 22.8 0.3 0.1 11.7 0.0 2.8 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 AMD19931.1 - 0.0001 21.4 0.0 0.044 12.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Arch_ATPase PF01637.13 AMD19931.1 - 0.00011 22.0 0.2 0.22 11.1 0.0 3.2 3 2 1 4 4 3 1 Archaeal ATPase Rad17 PF03215.10 AMD19931.1 - 0.0003 19.6 0.0 0.1 11.2 0.0 2.6 2 1 0 2 2 2 1 Rad17 cell cycle checkpoint protein Sigma54_activ_2 PF14532.1 AMD19931.1 - 0.00038 20.5 0.0 0.12 12.3 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.22 AMD19931.1 - 0.0007 19.9 0.0 0.013 15.8 0.0 2.4 2 0 0 2 2 2 1 ABC transporter IstB_IS21 PF01695.12 AMD19931.1 - 0.00085 18.7 0.0 1.4 8.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Bac_DnaA PF00308.13 AMD19931.1 - 0.0013 18.4 0.0 0.32 10.5 0.0 3.0 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_3 PF07726.6 AMD19931.1 - 0.0018 17.9 0.0 2.2 7.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 AMD19931.1 - 0.0039 16.7 0.0 0.71 9.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 AMD19931.1 - 0.0042 16.0 0.0 0.27 10.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.1 AMD19931.1 - 0.006 16.8 0.0 0.61 10.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 AMD19931.1 - 0.0069 15.8 0.0 5.4 6.4 0.0 3.6 4 0 0 4 4 3 0 Sigma-54 interaction domain AFG1_ATPase PF03969.11 AMD19931.1 - 0.015 14.1 0.0 0.096 11.4 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase NTPase_1 PF03266.10 AMD19931.1 - 0.02 14.6 0.0 2.2 7.9 0.0 3.0 2 1 1 3 3 2 0 NTPase AAA_24 PF13479.1 AMD19931.1 - 0.029 13.9 0.2 7.2 6.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 AMD19931.1 - 0.033 13.6 0.0 0.16 11.4 0.0 2.0 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain KAP_NTPase PF07693.9 AMD19931.1 - 0.034 13.1 0.0 0.4 9.6 0.0 2.6 1 1 1 2 2 2 0 KAP family P-loop domain Viral_helicase1 PF01443.13 AMD19931.1 - 0.043 13.3 0.0 0.26 10.7 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase SRPRB PF09439.5 AMD19931.1 - 0.057 12.6 0.0 0.32 10.2 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit UPF0079 PF02367.12 AMD19931.1 - 0.12 12.0 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 KaiC PF06745.8 AMD19931.1 - 0.12 11.4 2.3 10 5.1 0.0 3.7 3 2 2 5 5 5 0 KaiC HhH-GPD PF00730.20 AMD19932.1 - 0.093 13.0 0.0 0.18 12.0 0.0 1.5 1 1 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein DSHCT PF08148.7 AMD19933.1 - 1e-59 200.7 0.1 2.1e-59 199.8 0.1 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 AMD19933.1 - 5.6e-22 78.0 0.1 6e-21 74.6 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD19933.1 - 5.5e-07 29.3 0.0 2.3e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain rRNA_proc-arch PF13234.1 AMD19933.1 - 0.001 18.2 1.7 0.007 15.5 1.2 2.4 1 1 0 1 1 1 1 rRNA-processing arch domain ResIII PF04851.10 AMD19933.1 - 0.0019 18.0 0.0 0.012 15.4 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Bromodomain PF00439.20 AMD19934.1 - 2e-40 136.6 1.4 3.1e-19 68.6 0.2 2.6 2 0 0 2 2 2 2 Bromodomain Spt5_N PF11942.3 AMD19934.1 - 0.016 15.7 4.5 0.016 15.7 3.1 2.7 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal Macoilin PF09726.4 AMD19934.1 - 0.86 7.8 6.3 0.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Transmembrane protein Bap31 PF05529.7 AMD19935.1 - 1.6e-43 148.4 14.9 6.7e-43 146.3 10.3 1.7 1 1 0 1 1 1 1 B-cell receptor-associated protein 31-like Cortexin PF11057.3 AMD19935.1 - 0.09 12.3 1.3 1.2 8.7 0.0 2.6 2 1 0 2 2 2 0 Cortexin of kidney Dus PF01207.12 AMD19936.1 - 6.8e-46 156.5 0.0 5.1e-44 150.3 0.0 2.1 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 AMD19936.1 - 0.0027 17.3 0.1 0.0027 17.3 0.1 3.2 4 0 0 4 4 4 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C2H2_jaz PF12171.3 AMD19937.1 - 0.00028 20.9 5.7 0.13 12.4 0.0 3.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 AMD19937.1 - 0.0045 17.2 3.1 0.047 14.0 0.3 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger Nucleoplasmin PF03066.10 AMD19937.1 - 0.025 14.0 2.1 0.051 13.1 1.5 1.4 1 0 0 1 1 1 0 Nucleoplasmin zf-H2C2_2 PF13465.1 AMD19937.1 - 0.047 13.9 0.8 0.047 13.9 0.6 4.1 4 0 0 4 4 4 0 Zinc-finger double domain PBP1_TM PF14812.1 AMD19937.1 - 0.11 12.7 9.5 0.03 14.6 3.6 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal OPA3 PF07047.7 AMD19938.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 1 0 1 1 1 0 Optic atrophy 3 protein (OPA3) DUF1765 PF08578.5 AMD19939.1 - 3.4e-21 75.6 4.1 1.1e-20 74.0 2.8 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) BRE1 PF08647.6 AMD19940.1 - 9.6e-31 105.6 16.4 9.6e-31 105.6 11.4 6.2 6 2 1 7 7 7 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.1 AMD19940.1 - 2.7e-06 26.9 11.3 5.4e-06 25.9 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD19940.1 - 2.8e-06 27.2 12.8 6e-06 26.1 8.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD19940.1 - 1.5e-05 24.5 13.1 3.3e-05 23.4 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD19940.1 - 4.3e-05 23.1 13.0 9.2e-05 22.0 9.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 AMD19940.1 - 0.002 17.9 10.9 0.0043 16.8 7.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C2H2 PF00096.21 AMD19940.1 - 0.0046 17.2 0.1 0.0046 17.2 0.1 2.8 4 0 0 4 4 2 1 Zinc finger, C2H2 type Prok-RING_4 PF14447.1 AMD19940.1 - 0.1 12.1 5.6 0.22 11.0 3.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.1 AMD19940.1 - 0.24 11.1 4.7 0.6 9.9 3.3 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 AMD19940.1 - 0.26 11.0 7.3 1.2 8.9 5.1 2.3 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 AMD19940.1 - 0.46 10.1 10.2 0.94 9.1 7.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 AMD19940.1 - 4.2 7.3 12.2 3 7.7 6.8 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Dus PF01207.12 AMD19941.1 - 5e-75 252.2 0.0 6.1e-75 251.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Oxidored_FMN PF00724.15 AMD19941.1 - 0.021 13.8 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family DHO_dh PF01180.16 AMD19941.1 - 0.087 11.7 0.0 2 7.2 0.0 2.1 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase DUF1204 PF06721.6 AMD19941.1 - 0.17 11.0 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1204) Ribosomal_L31e PF01198.14 AMD19942.1 - 2.3e-37 126.5 2.3 2.7e-37 126.2 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Rxt3 PF08642.5 AMD19943.1 - 3.6e-31 107.7 0.0 5.7e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 RE_CfrBI PF09516.5 AMD19943.1 - 0.1 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 CfrBI restriction endonuclease DUF4050 PF13259.1 AMD19944.1 - 2.2e-21 76.0 2.3 4.6e-21 74.9 1.6 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF4050) GCN5L1 PF06320.8 AMD19945.1 - 0.00069 19.4 0.2 0.00086 19.1 0.2 1.3 1 1 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) NatB_MDM20 PF09797.4 AMD19945.1 - 0.065 11.9 0.3 0.063 11.9 0.2 1.0 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit Vps39_1 PF10366.4 AMD19946.1 - 1.8e-28 98.6 0.0 1.8e-28 98.6 0.0 3.0 2 1 1 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.4 AMD19946.1 - 9.3e-18 64.4 0.3 2.7e-17 62.8 0.2 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Utp21 PF04192.7 AMD19947.1 - 8.4e-81 270.5 0.9 1.2e-80 270.0 0.6 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 AMD19947.1 - 4.3e-24 83.4 10.0 3.8e-09 36.0 0.5 8.3 8 1 0 8 8 8 3 WD domain, G-beta repeat CPSF_A PF03178.10 AMD19947.1 - 7.2e-08 31.8 0.2 0.022 13.8 0.0 4.1 5 0 0 5 5 5 2 CPSF A subunit region eIF2A PF08662.6 AMD19947.1 - 0.0019 17.9 0.3 0.31 10.7 0.0 3.6 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 AMD19947.1 - 0.034 12.4 0.0 0.078 11.2 0.0 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain His_Phos_2 PF00328.17 AMD19948.1 - 6.3e-129 430.2 0.1 6.3e-129 430.2 0.1 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 AMD19948.1 - 1.1e-08 34.8 0.0 2.6e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 RimK-like ATP-grasp domain SYCE1 PF15233.1 AMD19948.1 - 0.17 11.7 3.9 0.28 11.0 1.9 2.0 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 Pribosyl_synth PF14572.1 AMD19949.1 - 6e-41 140.2 1.3 2.8e-32 111.9 0.1 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 AMD19949.1 - 3.6e-38 129.8 0.0 1.2e-37 128.2 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 AMD19949.1 - 5.4e-07 29.3 0.1 8.8e-06 25.4 0.1 2.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain SRR1 PF07985.7 AMD19950.1 - 8.4e-20 70.4 0.1 1.6e-19 69.5 0.1 1.5 1 0 0 1 1 1 1 SRR1 Acyl_transf_1 PF00698.16 AMD19951.1 - 4.7e-88 295.5 0.0 2e-87 293.4 0.0 2.1 3 0 0 3 3 3 1 Acyl transferase domain MaoC_dehydratas PF01575.14 AMD19951.1 - 1.8e-36 124.1 0.0 3.2e-36 123.4 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain DUF1729 PF08354.5 AMD19951.1 - 1.1e-29 101.9 0.0 2.8e-29 100.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 AMD19951.1 - 5.9e-14 51.9 0.0 1.7e-13 50.4 0.0 1.8 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase NMO PF03060.10 AMD19951.1 - 7.1e-06 25.3 0.4 6.9e-05 22.1 0.0 2.7 2 1 0 2 2 2 1 Nitronate monooxygenase Voldacs PF03517.8 AMD19952.1 - 9e-10 38.5 0.0 1.6e-09 37.6 0.0 1.4 1 1 0 1 1 1 1 Regulator of volume decrease after cellular swelling Orn_Arg_deC_N PF02784.11 AMD19953.1 - 3.1e-74 249.3 0.0 4.2e-74 248.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 AMD19953.1 - 4.4e-28 97.3 0.3 8.7e-28 96.3 0.2 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Mo25 PF08569.6 AMD19954.1 - 1.7e-124 415.2 6.8 1.9e-124 415.0 4.7 1.0 1 0 0 1 1 1 1 Mo25-like EAP30 PF04157.11 AMD19955.1 - 3.7e-38 130.9 0.8 1.1e-36 126.0 0.6 2.2 1 1 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 AMD19955.1 - 1.4e-32 111.3 0.4 3.7e-32 109.9 0.3 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.10 AMD19955.1 - 7.6e-05 22.1 3.9 0.00024 20.5 0.1 2.8 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger zf-RanBP PF00641.13 AMD19955.1 - 0.006 15.6 9.1 0.17 10.9 1.2 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Rubredoxin PF00301.15 AMD19955.1 - 0.32 10.9 2.1 2.4 8.1 0.0 2.8 2 1 1 3 3 3 0 Rubredoxin zf-MIZ PF02891.15 AMD19955.1 - 0.34 10.4 2.8 0.27 10.7 0.6 1.9 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger DZR PF12773.2 AMD19955.1 - 0.72 9.7 5.9 0.86 9.4 0.9 2.1 1 1 1 2 2 2 0 Double zinc ribbon ABC_membrane_2 PF06472.10 AMD19956.1 - 7.5e-63 212.2 5.8 3.7e-41 141.1 0.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.22 AMD19956.1 - 9e-18 64.8 0.0 2.1e-17 63.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AMD19956.1 - 4.8e-06 26.7 0.3 6.7e-05 23.0 0.0 3.0 2 1 1 3 3 3 1 AAA domain Lysis_S PF04971.7 AMD19956.1 - 0.0016 18.1 0.6 1.7 8.3 0.0 2.5 2 0 0 2 2 2 2 Lysis protein S AAA_29 PF13555.1 AMD19956.1 - 0.022 14.2 0.0 0.049 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 AMD19956.1 - 0.034 14.4 0.0 0.034 14.4 0.0 3.1 3 1 0 3 3 3 0 AAA domain SMC_N PF02463.14 AMD19956.1 - 0.036 13.2 0.2 0.13 11.4 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 AMD19956.1 - 0.08 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 AMD19956.1 - 0.081 12.6 0.7 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF258 PF03193.11 AMD19956.1 - 0.092 11.9 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Mg_chelatase PF01078.16 AMD19956.1 - 0.094 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SUR7 PF06687.7 AMD19957.1 - 1.3e-19 70.5 0.0 4.8e-19 68.7 0.0 1.8 1 1 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.3 AMD19957.1 - 5.1 6.9 16.1 0.36 10.7 7.5 1.7 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Mtr2 PF10429.4 AMD19958.1 - 3.4e-65 218.8 0.2 4e-65 218.5 0.2 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 GATA PF00320.22 AMD19959.1 - 9.1e-08 31.3 11.6 9.1e-08 31.3 8.0 3.3 4 0 0 4 4 4 1 GATA zinc finger zf-CCHC PF00098.18 AMD19960.1 - 6.2e-05 22.7 15.5 0.00084 19.1 1.3 5.0 6 0 0 6 6 6 3 Zinc knuckle DUF3590 PF12148.3 AMD19960.1 - 0.0055 16.3 2.6 0.012 15.2 1.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3590) zf-CCHC_4 PF14392.1 AMD19960.1 - 0.044 13.4 0.9 0.044 13.4 0.6 5.3 4 1 1 5 5 5 0 Zinc knuckle tRNA-synt_2b PF00587.20 AMD19961.1 - 1.6e-46 158.0 0.5 3.3e-46 157.0 0.3 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AMD19961.1 - 1e-19 70.2 0.6 2.6e-19 68.9 0.4 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 AMD19961.1 - 2.5e-13 49.6 0.0 5.3e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 AMD19961.1 - 4.6e-12 45.6 0.0 4.2e-11 42.5 0.0 2.2 2 0 0 2 2 2 1 TGS domain DUF1689 PF07954.6 AMD19962.1 - 4e-44 150.1 0.2 4e-44 150.1 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1689) Coatomer_E PF04733.9 AMD19963.1 - 2.1e-12 46.8 3.4 1e-11 44.6 2.4 1.9 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.1 AMD19963.1 - 0.0026 18.0 6.6 0.12 12.7 0.3 3.8 2 1 4 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 AMD19963.1 - 0.0027 17.7 1.9 0.12 12.5 0.2 2.7 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 GET2 PF08690.5 AMD19964.1 - 1e-71 241.6 0.0 1.2e-71 241.4 0.0 1.0 1 0 0 1 1 1 1 GET complex subunit GET2 Paramyxo_NS_C PF02725.9 AMD19964.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Non-structural protein C DHO_dh PF01180.16 AMD19965.1 - 1.1e-96 323.2 0.1 1.4e-96 322.9 0.1 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 AMD19965.1 - 6.7e-06 25.1 0.0 0.021 13.6 0.0 2.5 2 1 0 2 2 2 2 FMN-dependent dehydrogenase PcrB PF01884.12 AMD19965.1 - 0.016 14.5 0.1 3.1 6.9 0.0 2.2 2 0 0 2 2 2 0 PcrB family BING4CT PF08149.6 AMD19966.1 - 5.7e-39 131.5 0.0 2.8e-36 122.8 0.0 3.5 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.27 AMD19966.1 - 1.4e-06 27.9 0.0 0.00063 19.5 0.0 3.9 5 0 0 5 5 5 1 WD domain, G-beta repeat PQQ_2 PF13360.1 AMD19966.1 - 0.04 13.3 0.0 0.33 10.3 0.0 2.0 1 1 1 2 2 2 0 PQQ-like domain Formyl_trans_C PF02911.13 AMD19966.1 - 0.055 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain PC_rep PF01851.17 AMD19967.1 - 4e-39 130.6 15.2 5e-06 26.4 0.0 9.9 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.1 AMD19967.1 - 2.1e-18 66.3 0.7 7.8e-13 48.5 0.0 4.6 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.17 AMD19967.1 - 4e-09 35.7 0.6 0.9 9.7 0.0 5.4 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.1 AMD19967.1 - 4.2e-05 23.8 3.9 0.8 10.2 0.0 5.1 3 2 1 5 5 5 3 HEAT-like repeat DUF3549 PF12069.3 AMD19967.1 - 0.0014 17.4 1.6 0.0028 16.4 1.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3549) RICTOR_V PF14668.1 AMD19967.1 - 0.094 12.6 0.1 1.5 8.7 0.0 3.0 3 1 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 2-Hacid_dh_C PF02826.14 AMD19968.1 - 2.9e-55 186.1 0.0 5.3e-55 185.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 AMD19968.1 - 4.7e-38 129.6 0.1 6.2e-38 129.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 AMD19968.1 - 3.5e-05 23.6 0.1 8e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 AMD19968.1 - 7.7e-05 22.5 0.1 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Acetyltransf_1 PF00583.19 AMD19968.1 - 0.0047 16.9 0.0 0.011 15.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family ACT PF01842.20 AMD19968.1 - 0.011 15.2 0.0 0.032 13.7 0.0 1.8 1 0 0 1 1 1 0 ACT domain DUF4367 PF14285.1 AMD19968.1 - 0.071 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) EF-hand_1 PF00036.27 AMD19969.1 - 6.7e-23 78.2 12.7 1.4e-05 24.0 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 AMD19969.1 - 1.3e-19 70.0 7.1 1.3e-10 41.1 1.7 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 AMD19969.1 - 4.6e-19 66.5 6.3 0.00037 20.1 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 AMD19969.1 - 3.8e-16 57.5 13.6 0.0016 17.6 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 AMD19969.1 - 2.2e-12 46.3 15.0 0.00065 19.2 1.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.2 AMD19969.1 - 3.6e-07 29.8 7.2 0.0073 16.0 0.2 3.7 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 AMD19969.1 - 1.4e-06 28.2 0.0 0.013 15.5 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 AMD19969.1 - 0.0013 18.5 0.0 2 8.3 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain CDC73 PF05179.9 AMD19970.1 - 3.2e-65 220.2 1.9 4.1e-65 219.8 1.3 1.1 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family OB_NTP_bind PF07717.11 AMD19971.1 - 3.8e-19 68.6 0.0 1.2e-18 67.0 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 AMD19971.1 - 1.4e-11 44.1 0.6 4.2e-11 42.6 0.4 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase RWD PF05773.17 AMD19971.1 - 6.3e-11 42.1 0.6 1.9e-10 40.5 0.4 1.9 1 0 0 1 1 1 1 RWD domain Helicase_C PF00271.26 AMD19971.1 - 1.8e-10 40.5 0.1 6e-10 38.8 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.18 AMD19971.1 - 4.6e-09 36.2 0.0 2e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) PhoH PF02562.11 AMD19971.1 - 0.00045 19.5 0.4 0.0025 17.0 0.0 2.3 3 0 0 3 3 3 1 PhoH-like protein AAA_29 PF13555.1 AMD19971.1 - 0.00045 19.6 0.0 0.00098 18.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SE PF00437.15 AMD19971.1 - 0.00082 18.3 0.1 0.0016 17.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein UBA PF00627.26 AMD19971.1 - 0.0013 18.5 0.1 0.0035 17.1 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain AAA_16 PF13191.1 AMD19971.1 - 0.0014 18.6 0.1 0.021 14.8 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain KaiC PF06745.8 AMD19971.1 - 0.0044 16.1 0.0 0.011 14.8 0.0 1.6 1 0 0 1 1 1 1 KaiC Zot PF05707.7 AMD19971.1 - 0.0061 16.0 0.1 0.022 14.2 0.1 2.0 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_19 PF13245.1 AMD19971.1 - 0.0068 16.1 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 AMD19971.1 - 0.012 15.8 0.1 0.04 14.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 AMD19971.1 - 0.078 12.3 0.0 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 AMD19971.1 - 0.11 12.0 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.1 AMD19971.1 - 3.8 7.7 12.2 0.12 12.6 0.1 3.7 4 0 0 4 4 3 0 AAA domain Y_phosphatase PF00102.22 AMD19972.1 - 1.7e-52 178.1 0.0 3.1e-52 177.2 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 AMD19972.1 - 1.9e-09 37.8 0.0 1.4e-08 35.1 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.15 AMD19972.1 - 0.0041 16.7 0.0 0.011 15.3 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 AMD19972.1 - 0.063 13.5 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Yos1 PF08571.5 AMD19973.1 - 5.6e-30 103.2 1.9 6.3e-30 103.1 1.3 1.0 1 0 0 1 1 1 1 Yos1-like Ribosomal_S24e PF01282.14 AMD19974.1 - 1.6e-34 117.5 0.1 2.4e-34 116.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e Aldedh PF00171.17 AMD19975.1 - 7e-181 601.5 0.0 7.9e-181 601.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Tctex-1 PF03645.8 AMD19976.1 - 1.3e-07 31.4 0.0 1.9e-07 30.8 0.0 1.3 1 1 0 1 1 1 1 Tctex-1 family Sec6 PF06046.8 AMD19977.1 - 5.2e-149 496.9 15.9 6.8e-149 496.5 11.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 Laminin_II PF06009.7 AMD19977.1 - 1.7 8.4 10.9 0.027 14.2 1.0 2.9 4 0 0 4 4 4 0 Laminin Domain II LCCL PF03815.14 AMD19978.1 - 3.4e-12 46.1 0.3 5.9e-12 45.4 0.2 1.4 1 0 0 1 1 1 1 LCCL domain DUF1069 PF06370.6 AMD19978.1 - 0.0058 16.0 0.0 0.0096 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1069) Ribonuc_red_lgC PF02867.10 AMD19979.1 - 7.7e-217 721.1 0.0 1.1e-216 720.5 0.0 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 AMD19979.1 - 1.2e-23 82.6 0.1 4.1e-23 80.9 0.0 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 AMD19979.1 - 3.4e-17 62.6 0.1 1.2e-15 57.6 0.0 3.1 2 0 0 2 2 2 1 ATP cone domain NRDD PF13597.1 AMD19979.1 - 0.012 13.7 0.0 0.021 12.9 0.0 1.4 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase Peptidase_C24 PF03510.9 AMD19979.1 - 0.15 12.2 2.0 0.33 11.1 0.7 2.0 2 0 0 2 2 2 0 2C endopeptidase (C24) cysteine protease family Fis1_TPR_C PF14853.1 AMD19980.1 - 2.7e-21 75.1 0.7 4.3e-21 74.5 0.5 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 AMD19980.1 - 2.4e-16 58.7 0.0 5.1e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat OSCP PF00213.13 AMD19980.1 - 0.057 13.2 0.2 2 8.2 0.1 2.1 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit QLQ PF08880.6 AMD19980.1 - 0.081 12.3 0.1 0.17 11.3 0.1 1.6 1 0 0 1 1 1 0 QLQ Methyltransf_31 PF13847.1 AMD19981.1 - 2.2e-27 95.5 0.0 3.2e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD19981.1 - 9.8e-20 71.2 0.0 1.4e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD19981.1 - 4.5e-10 39.9 0.0 7.6e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD19981.1 - 8.9e-09 35.7 0.0 1.8e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 AMD19981.1 - 3.9e-08 33.0 0.0 6e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AMD19981.1 - 6.3e-08 32.6 0.0 1.5e-07 31.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD19981.1 - 1.2e-07 32.0 0.0 2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AMD19981.1 - 1.3e-06 27.8 0.0 2.3e-06 27.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 AMD19981.1 - 8.1e-06 25.6 0.0 1.4e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 AMD19981.1 - 2.3e-05 24.0 0.0 3.8e-05 23.3 0.0 1.3 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 AMD19981.1 - 2.8e-05 23.3 0.1 3.7e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TPMT PF05724.6 AMD19981.1 - 5.4e-05 22.7 0.0 0.00011 21.7 0.0 1.5 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_4 PF02390.12 AMD19981.1 - 0.0003 19.8 0.0 0.00078 18.5 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase AdoMet_MTase PF07757.8 AMD19981.1 - 0.0016 18.5 0.0 0.0025 17.9 0.0 1.5 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase DOT1 PF08123.8 AMD19981.1 - 0.0021 17.3 0.0 0.0036 16.6 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 MetW PF07021.7 AMD19981.1 - 0.0074 15.6 0.0 0.013 14.9 0.0 1.6 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.13 AMD19981.1 - 0.0085 15.2 0.0 0.013 14.6 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.9 AMD19981.1 - 0.013 14.7 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB PrmA PF06325.8 AMD19981.1 - 0.023 13.8 0.0 0.047 12.8 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Ran_BP1 PF00638.13 AMD19982.1 - 1.3e-31 109.1 0.0 2.3e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain P16-Arc PF04699.9 AMD19983.1 - 2.9e-47 160.4 0.0 3.2e-47 160.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Acetone_carb_G PF08882.6 AMD19983.1 - 0.065 13.2 0.0 0.096 12.7 0.0 1.3 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit Sigma70_r4 PF04545.11 AMD19983.1 - 0.085 12.1 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 DUF619 PF04768.8 AMD19984.1 - 1e-40 138.9 0.0 2.8e-40 137.5 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF619) Semialdhyde_dh PF01118.19 AMD19984.1 - 3.1e-27 95.2 0.0 1.4e-26 93.1 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.23 AMD19984.1 - 1.3e-20 73.9 0.1 2.1e-19 70.0 0.0 2.6 3 0 0 3 3 3 1 Amino acid kinase family Semialdhyde_dhC PF02774.13 AMD19984.1 - 2.1e-07 30.9 0.0 1.3e-06 28.3 0.0 2.4 3 0 0 3 3 3 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.15 AMD19984.1 - 0.014 15.3 0.0 0.044 13.7 0.0 1.9 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus U1snRNP70_N PF12220.3 AMD19985.1 - 1.6e-19 69.9 2.2 1.6e-19 69.9 1.5 1.6 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 AMD19985.1 - 9.4e-16 57.2 0.0 2.3e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD19985.1 - 8.6e-14 51.2 0.0 1.5e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD19985.1 - 3e-05 23.7 0.0 5.2e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_4 PF14570.1 AMD19986.1 - 7.8e-20 70.2 13.3 1.5e-19 69.3 9.2 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.17 AMD19986.1 - 7.8e-09 35.0 0.0 1.9e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD19986.1 - 8.5e-09 35.1 0.2 2e-08 33.9 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_IE-1 PF05290.6 AMD19986.1 - 2.8e-06 27.1 3.9 2.8e-06 27.1 2.7 2.0 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) zf-C3HC4_3 PF13920.1 AMD19986.1 - 3.6e-06 26.5 7.2 8.1e-06 25.4 5.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_6 PF14259.1 AMD19986.1 - 1.4e-05 24.9 0.1 4.6e-05 23.3 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.1 AMD19986.1 - 0.00073 19.3 8.9 0.0016 18.2 6.2 1.6 1 0 0 1 1 1 1 Ring finger domain Rtf2 PF04641.7 AMD19986.1 - 0.00076 18.7 3.0 0.00076 18.7 2.1 3.0 3 0 0 3 3 3 1 Rtf2 RING-finger zf-C3HC4 PF00097.20 AMD19986.1 - 0.0026 17.3 11.3 0.0059 16.2 7.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SET_assoc PF11767.3 AMD19986.1 - 0.0037 16.5 0.1 0.017 14.4 0.0 2.1 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated zf-UDP PF14569.1 AMD19986.1 - 0.028 14.1 4.0 0.082 12.6 2.8 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4_2 PF13923.1 AMD19986.1 - 0.04 13.9 10.9 0.086 12.8 7.5 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD19986.1 - 0.34 10.6 10.0 0.77 9.5 6.9 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.1 AMD19986.1 - 0.4 10.5 9.8 1.8 8.5 6.8 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF342 PF03961.8 AMD19986.1 - 9.5 4.5 15.2 0.077 11.4 4.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF342) DUF2578 PF10843.3 AMD19987.1 - 1.1e-61 207.8 16.3 1.4e-61 207.6 11.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2578) DUF4309 PF14172.1 AMD19987.1 - 0.034 14.1 1.8 0.53 10.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4309) VRP3 PF03536.10 AMD19987.1 - 0.067 12.3 0.2 0.46 9.5 0.1 1.9 1 1 1 2 2 2 0 Salmonella virulence-associated 28kDa protein ICL PF00463.16 AMD19988.1 - 8.2e-252 836.0 0.1 9.4e-252 835.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 AMD19988.1 - 2e-10 40.2 0.0 4.2e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Arg_repressor_C PF02863.13 AMD19988.1 - 0.015 14.7 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain Vhr1 PF04001.8 AMD19989.1 - 6.1e-48 160.6 2.7 1.4e-47 159.4 1.9 1.6 1 0 0 1 1 1 1 Transcription factor Vhr1 Cys_rich_KTR PF14205.1 AMD19989.1 - 0.059 12.8 0.3 2.5 7.6 0.0 2.6 2 0 0 2 2 2 0 Cysteine-rich KTR SAP PF02037.22 AMD19991.1 - 1.7e-13 49.6 0.6 4.8e-13 48.2 0.1 1.9 2 0 0 2 2 2 1 SAP domain DUF3275 PF11679.3 AMD19991.1 - 3.5 7.2 5.2 4.5 6.8 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) HAD_2 PF13419.1 AMD19992.1 - 1.4e-10 41.7 0.0 2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AMD19992.1 - 9.1e-07 28.5 0.0 1.6e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 AMD19992.1 - 3.7e-06 27.5 0.0 0.00011 22.6 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ketoacyl-synt PF00109.21 AMD19993.1 - 9.5e-50 169.4 0.0 1.5e-49 168.8 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 AMD19993.1 - 6.9e-28 96.8 0.4 1.1e-27 96.2 0.3 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 AMD19993.1 - 0.092 11.7 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain Steroid_dh PF02544.11 AMD19994.1 - 2e-14 53.6 3.5 2e-14 53.6 2.4 2.0 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase TraA PF05513.6 AMD19994.1 - 0.021 14.9 0.5 0.77 9.9 0.1 2.9 3 0 0 3 3 3 0 TraA Transp_cyt_pur PF02133.10 AMD19995.1 - 8.1e-48 163.0 44.0 9.6e-48 162.8 30.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Cyclin PF08613.6 AMD19996.1 - 1e-44 152.5 0.6 1.6e-44 151.9 0.4 1.3 1 0 0 1 1 1 1 Cyclin Ribonuc_L-PSP PF01042.16 AMD19998.1 - 2.6e-43 146.6 0.2 3e-43 146.4 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP GIT1_C PF12205.3 AMD19998.1 - 0.088 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Ribosomal_L34e PF01199.13 AMD19999.1 - 2.5e-36 123.7 3.9 2.5e-36 123.7 2.7 1.7 2 0 0 2 2 2 1 Ribosomal protein L34e DUF1428 PF07237.6 AMD19999.1 - 0.053 13.4 0.1 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) EndIII_4Fe-2S PF10576.4 AMD19999.1 - 0.22 11.7 0.1 0.22 11.7 0.1 2.1 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III E1-E2_ATPase PF00122.15 AMD20000.1 - 2.1e-26 92.3 0.1 5e-26 91.1 0.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 AMD20000.1 - 7e-12 46.2 0.0 3.8e-11 43.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 AMD20000.1 - 3e-09 36.6 0.0 5.5e-07 29.4 0.0 2.6 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 AMD20000.1 - 4.7e-09 36.6 0.1 1.6e-08 34.9 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AMD20000.1 - 0.0039 16.8 0.1 0.013 15.1 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase EXS PF03124.9 AMD20001.1 - 1.7e-85 287.0 28.2 2.3e-85 286.6 19.6 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.14 AMD20001.1 - 1.4e-36 126.7 0.1 3.9e-36 125.2 0.1 1.8 1 1 0 1 1 1 1 SPX domain HisG PF01634.13 AMD20002.1 - 3.2e-50 169.9 0.1 4.7e-50 169.3 0.1 1.3 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 AMD20002.1 - 2.1e-26 91.6 0.0 4.8e-26 90.4 0.0 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.6 AMD20002.1 - 0.0067 16.0 0.1 0.0088 15.6 0.0 1.3 1 0 0 1 1 1 1 NMT1/THI5 like WD40 PF00400.27 AMD20003.1 - 1.9e-52 173.3 29.2 1.6e-09 37.2 0.9 8.2 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.2 AMD20003.1 - 1.4e-13 50.3 0.8 3.3e-13 49.1 0.5 1.7 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.3 AMD20003.1 - 5.6e-09 34.6 13.1 0.022 12.9 0.1 5.6 1 1 4 6 6 6 4 Nucleoporin Nup120/160 F-box PF00646.28 AMD20003.1 - 1.5e-08 34.0 0.1 4.5e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 F-box domain BBS2_Mid PF14783.1 AMD20003.1 - 0.0007 19.3 0.1 1.1 9.0 0.0 3.6 2 1 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.6 AMD20003.1 - 0.0073 15.0 3.7 5.1 5.7 0.7 3.8 2 1 1 3 3 3 2 Nup133 N terminal like PRANC PF09372.5 AMD20003.1 - 0.084 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 PRANC domain CBM_21 PF03370.8 AMD20004.1 - 1.1e-24 86.5 0.0 2e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit CBM_25 PF03423.8 AMD20004.1 - 0.012 15.6 0.4 0.12 12.5 0.3 2.2 1 1 0 1 1 1 0 Carbohydrate binding domain (family 25) nec1 PF10379.4 AMD20004.1 - 0.046 12.9 0.1 0.075 12.3 0.1 1.3 1 0 0 1 1 1 0 Virulence protein nec1 ArfGap PF01412.13 AMD20005.1 - 3.1e-35 120.4 0.5 1e-34 118.8 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Cyt-b5 PF00173.23 AMD20006.1 - 9.9e-21 73.3 0.0 2e-20 72.3 0.0 1.5 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AA_kinase PF00696.23 AMD20007.1 - 1.1e-38 133.2 0.1 1.8e-38 132.4 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 AMD20007.1 - 1.3e-11 43.7 0.3 3.1e-07 29.7 0.2 2.5 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 AMD20007.1 - 1.5e-09 37.2 2.2 4.4e-07 29.3 0.4 2.7 2 0 0 2 2 2 2 ACT domain FAD_binding_6 PF00970.19 AMD20008.1 - 2.9e-28 97.8 0.0 4.4e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 AMD20008.1 - 4.4e-28 98.0 0.0 9e-28 97.0 0.0 1.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 AMD20008.1 - 2e-06 27.8 0.0 0.001 19.0 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain PHD PF00628.24 AMD20009.1 - 1.2e-07 31.2 5.2 2.4e-07 30.3 3.6 1.5 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.1 AMD20009.1 - 4.8e-07 29.5 0.0 1.4e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 AMD20009.1 - 0.0056 16.9 0.0 0.054 13.7 0.0 2.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-CW PF07496.10 AMD20009.1 - 0.017 14.8 2.8 0.78 9.4 0.5 2.7 2 0 0 2 2 2 0 CW-type Zinc Finger Cupin_2 PF07883.6 AMD20009.1 - 0.019 14.4 0.0 0.046 13.2 0.0 1.6 1 0 0 1 1 1 0 Cupin domain Cupin_4 PF08007.7 AMD20009.1 - 0.056 12.6 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Cupin superfamily protein Cupin_1 PF00190.17 AMD20009.1 - 0.064 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Cupin zf-HC5HC2H_2 PF13832.1 AMD20009.1 - 0.097 12.6 3.3 0.18 11.8 2.3 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 AMD20009.1 - 0.59 10.3 5.6 0.25 11.5 2.0 1.8 2 0 0 2 2 2 0 PHD-like zinc-binding domain Peptidase_C48 PF02902.14 AMD20010.1 - 1.6e-34 119.4 2.5 1.6e-34 119.4 1.8 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain RINGv PF12906.2 AMD20011.1 - 1.9e-14 53.4 7.0 3.3e-14 52.6 4.8 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 AMD20011.1 - 0.044 13.6 6.8 0.091 12.5 4.7 1.6 1 0 0 1 1 1 0 Ring finger domain PBP PF01161.15 AMD20011.1 - 0.25 11.1 0.2 0.54 10.0 0.1 1.5 1 0 0 1 1 1 0 Phosphatidylethanolamine-binding protein Sugar_tr PF00083.19 AMD20012.1 - 9.9e-90 301.2 28.8 3.4e-69 233.5 11.8 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 AMD20012.1 - 4.2e-24 84.9 30.0 1.2e-22 80.1 15.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 AMD20012.1 - 0.2 10.0 29.9 0.024 13.0 6.0 3.2 3 1 0 3 3 3 0 MFS/sugar transport protein DUF2373 PF10180.4 AMD20013.1 - 2.4e-23 81.4 0.0 3.8e-23 80.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Sin3_corepress PF08295.7 AMD20013.1 - 0.07 12.8 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Sin3 family co-repressor HAD PF12710.2 AMD20014.1 - 1.2e-06 28.8 0.1 1.6e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AMD20014.1 - 0.063 12.9 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like DNA_pol_B_palm PF14792.1 AMD20015.1 - 3.1e-12 46.5 0.0 1.1e-11 44.7 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 AMD20015.1 - 5.8e-11 41.9 0.0 1.3e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.1 AMD20015.1 - 1.7e-10 40.9 0.0 3.7e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.4 AMD20015.1 - 2.5e-10 39.7 1.4 6.4e-10 38.4 0.4 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda PGK PF00162.14 AMD20016.1 - 4.6e-153 509.3 0.4 5.3e-153 509.1 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase TauD PF02668.11 AMD20018.1 - 3.4e-43 148.1 0.5 4.4e-43 147.8 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 AMD20018.1 - 0.00097 18.1 0.1 0.37 9.6 0.0 2.1 2 0 0 2 2 2 2 CsiD DUF971 PF06155.7 AMD20018.1 - 0.005 17.2 0.0 1.8 9.0 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF971) 2OG-FeII_Oxy_3 PF13640.1 AMD20018.1 - 0.0076 16.7 0.2 0.26 11.8 0.0 2.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily GTP_EFTU PF00009.22 AMD20019.1 - 2.5e-34 118.3 4.8 1.4e-33 115.8 3.4 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 AMD20019.1 - 9.5e-25 86.6 1.7 2.1e-24 85.4 1.2 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.18 AMD20019.1 - 1.7e-06 27.9 1.0 3e-05 23.9 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 AMD20019.1 - 2.8e-05 24.5 0.3 0.00016 22.1 0.1 2.2 2 0 0 2 2 2 1 Miro-like protein GTP_EFTU_D2 PF03144.20 AMD20019.1 - 0.00011 22.2 1.3 0.045 13.8 0.0 3.5 3 0 0 3 3 3 1 Elongation factor Tu domain 2 PduV-EutP PF10662.4 AMD20019.1 - 0.0012 18.3 4.9 0.0019 17.7 1.6 2.5 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 AMD20019.1 - 0.0047 16.7 0.2 2.1 8.1 0.0 2.7 1 1 1 2 2 2 2 Dynamin family PDCD2_C PF04194.8 AMD20020.1 - 1.2e-42 145.3 0.3 1.2e-39 135.5 0.0 2.7 2 1 1 3 3 3 2 Programmed cell death protein 2, C-terminal putative domain DUF1462 PF07315.6 AMD20020.1 - 0.1 12.5 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) WD40 PF00400.27 AMD20021.1 - 3.5e-48 159.8 15.6 4.1e-11 42.2 0.0 7.6 8 0 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.3 AMD20021.1 - 1.2e-10 40.1 12.4 0.0036 15.5 0.5 4.9 2 1 2 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 AMD20021.1 - 1.2e-05 24.2 1.6 0.16 10.6 0.1 3.6 1 1 1 2 2 2 2 Nup133 N terminal like DUF3312 PF11768.3 AMD20021.1 - 0.00013 20.3 0.0 0.00063 18.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3312) RFX_DNA_binding PF02257.10 AMD20022.1 - 8.3e-32 109.1 0.0 2e-31 107.9 0.0 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain Pyrophosphatase PF00719.14 AMD20022.1 - 0.00014 21.3 1.6 0.00094 18.6 0.1 2.4 2 1 0 3 3 3 1 Inorganic pyrophosphatase Pox_D5 PF03288.11 AMD20022.1 - 0.0029 17.8 0.0 0.075 13.3 0.0 2.6 2 0 0 2 2 2 1 Poxvirus D5 protein-like DUF2262 PF10020.4 AMD20022.1 - 0.044 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) Cdc6_C PF09079.6 AMD20022.1 - 0.096 12.4 0.0 0.32 10.7 0.0 1.9 1 0 0 1 1 1 0 CDC6, C terminal BAF1_ABF1 PF04684.8 AMD20022.1 - 3.3 6.4 11.8 5.3 5.7 8.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Ribosomal_L30 PF00327.15 AMD20023.1 - 8.7e-11 41.2 0.8 1.8e-10 40.2 0.6 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Iso_dh PF00180.15 AMD20024.1 - 8.2e-128 426.2 0.0 9.4e-128 426.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aminotran_5 PF00266.14 AMD20025.1 - 1.5e-99 333.2 0.0 1.8e-99 333.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 AMD20025.1 - 2.4e-09 36.7 0.0 3.2e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 AMD20025.1 - 6.5e-09 35.2 0.0 1.3e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.14 AMD20025.1 - 5.3e-05 21.8 0.1 7.8e-05 21.2 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.15 AMD20025.1 - 0.0019 16.5 0.1 0.0031 15.8 0.1 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mito_carr PF00153.22 AMD20026.1 - 1.5e-52 175.2 4.0 6.7e-18 64.2 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein COG5 PF10392.4 AMD20026.1 - 0.019 14.9 0.4 0.029 14.3 0.3 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF2036 PF09724.4 AMD20027.1 - 4.1e-75 252.9 0.0 4.8e-75 252.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) DUF3507 PF12015.3 AMD20028.1 - 5.5e-58 195.4 0.0 1.5e-57 194.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) RRM_1 PF00076.17 AMD20029.1 - 7.3e-51 169.6 0.0 3.4e-18 65.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD20029.1 - 1.6e-30 104.8 0.0 3.5e-11 42.9 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20029.1 - 5.3e-08 32.5 0.0 0.011 15.5 0.0 3.6 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1325 PF07039.6 AMD20030.1 - 3.5e-35 120.4 0.0 7.2e-35 119.4 0.0 1.5 2 0 0 2 2 2 1 SGF29 tudor-like domain Agenet PF05641.7 AMD20030.1 - 0.0011 19.1 0.0 0.58 10.3 0.0 2.4 2 0 0 2 2 2 2 Agenet domain DUF4537 PF15057.1 AMD20030.1 - 0.028 14.2 0.0 0.059 13.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) DUF4375 PF14300.1 AMD20030.1 - 0.11 12.4 1.4 0.17 11.8 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) BLOC1_2 PF10046.4 AMD20030.1 - 0.14 12.2 2.3 0.21 11.7 1.6 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ribosomal_L27 PF01016.14 AMD20031.1 - 3.5e-31 106.8 0.1 5.4e-31 106.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein DDE_Tnp_IS66 PF03050.9 AMD20031.1 - 0.0045 16.2 0.2 0.0082 15.3 0.1 1.4 1 0 0 1 1 1 1 Transposase IS66 family ALS_ss_C PF10369.4 AMD20032.1 - 2.8e-20 71.8 0.0 1.4e-19 69.5 0.0 2.1 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.20 AMD20032.1 - 2.1e-10 39.8 0.1 4.4e-10 38.8 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 AMD20032.1 - 2.9e-08 33.3 0.0 5.1e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.1 AMD20032.1 - 0.019 15.3 0.1 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 ACT domain Limkain-b1 PF11608.3 AMD20032.1 - 0.077 12.7 0.0 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 Limkain b1 Iso_dh PF00180.15 AMD20033.1 - 3e-72 243.4 0.0 3.5e-72 243.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HAD PF12710.2 AMD20034.1 - 6.6e-18 65.5 0.0 9.3e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 AMD20034.1 - 8.1e-10 38.2 0.0 1.1e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.7 AMD20034.1 - 2.3e-06 27.1 0.0 4.4e-05 22.9 0.0 2.2 1 1 1 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.1 AMD20034.1 - 5.8e-06 26.6 0.0 8.1e-05 22.9 0.0 2.3 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AMD20034.1 - 0.00072 20.0 0.0 0.38 11.1 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase SpoU_sub_bind PF08032.7 AMD20034.1 - 0.06 13.5 0.0 6 7.1 0.0 2.7 2 1 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding UPF0052 PF01933.13 AMD20035.1 - 2.7e-61 207.5 0.0 3.8e-61 207.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 EF-hand_7 PF13499.1 AMD20036.1 - 3.8e-06 26.9 0.8 3.8e-06 26.9 0.6 1.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 AMD20036.1 - 7.4e-06 24.9 4.1 0.0025 16.9 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 AMD20036.1 - 2.2e-05 23.9 3.0 0.062 12.9 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 AMD20036.1 - 8.9e-05 22.0 1.3 0.13 12.1 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain Flavodoxin_1 PF00258.20 AMD20036.1 - 0.048 13.6 0.5 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 Flavodoxin CAF1-p150_N PF15557.1 AMD20037.1 - 0.11 11.7 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to PCNA PLA2_B PF01735.13 AMD20038.1 - 6e-94 314.9 6.3 3.2e-81 272.9 0.2 2.1 2 0 0 2 2 2 2 Lysophospholipase catalytic domain ABC_tran PF00005.22 AMD20039.1 - 2.1e-45 154.3 0.1 3.3e-23 82.4 0.0 4.6 3 2 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 AMD20039.1 - 9.3e-18 65.1 0.0 0.0017 18.3 0.0 4.6 3 1 0 4 4 4 4 AAA domain SMC_N PF02463.14 AMD20039.1 - 5.2e-17 61.8 0.0 1.2e-06 27.9 0.0 4.0 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 AMD20039.1 - 1.1e-09 38.9 2.6 0.0032 17.8 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 AMD20039.1 - 2.2e-09 36.7 0.0 0.0027 17.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 AMD20039.1 - 5.2e-09 36.3 0.0 0.00033 20.8 0.0 4.0 4 1 0 4 4 3 2 AAA domain AAA_17 PF13207.1 AMD20039.1 - 4.4e-08 33.9 0.0 0.0061 17.3 0.0 3.1 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 AMD20039.1 - 5.6e-08 32.1 0.0 0.0012 18.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Dynamin_N PF00350.18 AMD20039.1 - 2.6e-07 30.6 0.0 2.7e-05 24.0 0.0 3.2 4 0 0 4 4 2 1 Dynamin family AAA_28 PF13521.1 AMD20039.1 - 2.7e-07 30.6 0.0 0.0064 16.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 AMD20039.1 - 7.4e-07 29.1 0.0 0.0057 16.6 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase SbcCD_C PF13558.1 AMD20039.1 - 8.7e-07 28.7 0.0 0.01 15.7 0.0 3.8 3 1 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA PF00004.24 AMD20039.1 - 1.8e-06 28.1 0.1 0.59 10.3 0.0 4.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 AMD20039.1 - 5.4e-06 26.0 0.0 0.26 10.6 0.0 3.5 4 0 0 4 4 4 2 AAA-like domain AAA_33 PF13671.1 AMD20039.1 - 5.5e-06 26.3 0.0 0.17 11.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain CLASP_N PF12348.3 AMD20039.1 - 6e-06 25.7 0.9 0.0076 15.6 0.0 2.8 1 1 1 2 2 2 2 CLASP N terminal Miro PF08477.8 AMD20039.1 - 6.5e-06 26.6 0.0 0.05 14.0 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_15 PF13175.1 AMD20039.1 - 8.5e-06 25.0 0.0 0.96 8.4 0.0 3.9 3 1 0 4 4 4 1 AAA ATPase domain RNA_helicase PF00910.17 AMD20039.1 - 1e-05 25.6 0.0 0.098 12.8 0.0 2.9 2 0 0 2 2 2 2 RNA helicase Arch_ATPase PF01637.13 AMD20039.1 - 1.1e-05 25.2 0.0 0.31 10.7 0.0 3.3 3 0 0 3 3 2 2 Archaeal ATPase ArgK PF03308.11 AMD20039.1 - 1.6e-05 23.8 0.1 0.17 10.6 0.0 2.5 2 0 0 2 2 2 2 ArgK protein HEAT_2 PF13646.1 AMD20039.1 - 2.2e-05 24.6 0.2 0.012 15.9 0.0 3.4 1 1 2 3 3 3 1 HEAT repeats MobB PF03205.9 AMD20039.1 - 3.5e-05 23.5 0.1 0.3 10.7 0.0 3.2 3 0 0 3 3 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 AMD20039.1 - 4.8e-05 23.6 0.1 0.1 12.8 0.0 3.4 4 0 0 4 4 2 1 AAA domain MutS_V PF00488.16 AMD20039.1 - 9.1e-05 21.9 0.0 0.015 14.7 0.0 2.4 2 0 0 2 2 2 1 MutS domain V AAA_16 PF13191.1 AMD20039.1 - 0.0001 22.3 0.5 0.28 11.1 0.0 3.6 4 0 0 4 4 3 1 AAA ATPase domain AAA_14 PF13173.1 AMD20039.1 - 0.00012 22.0 0.0 0.68 9.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_13 PF13166.1 AMD20039.1 - 0.0006 18.4 4.5 1.7 7.0 0.0 4.2 3 1 0 4 4 4 1 AAA domain AAA_30 PF13604.1 AMD20039.1 - 0.00068 19.2 0.0 1.6 8.2 0.0 3.5 4 0 0 4 4 3 1 AAA domain PduV-EutP PF10662.4 AMD20039.1 - 0.0008 18.9 0.0 0.35 10.3 0.0 3.3 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.7 AMD20039.1 - 0.0011 18.6 0.0 0.98 9.0 0.0 2.8 3 0 0 3 3 2 1 NACHT domain cobW PF02492.14 AMD20039.1 - 0.0013 18.1 0.2 0.72 9.2 0.0 2.9 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain HEAT_EZ PF13513.1 AMD20039.1 - 0.0023 18.3 3.0 0.18 12.3 0.0 4.6 4 2 1 5 5 4 1 HEAT-like repeat AAA_25 PF13481.1 AMD20039.1 - 0.005 16.2 0.0 2.6 7.3 0.0 3.3 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.7 AMD20039.1 - 0.0059 15.7 0.1 1.1 8.3 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin Vac14_Fab1_bd PF12755.2 AMD20039.1 - 0.0068 16.7 0.4 0.91 9.9 0.0 3.3 3 1 0 4 4 2 1 Vacuolar 14 Fab1-binding region T2SE PF00437.15 AMD20039.1 - 0.0071 15.2 0.1 0.47 9.3 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein Rad17 PF03215.10 AMD20039.1 - 0.0072 15.0 0.0 1.7 7.2 0.0 2.3 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein ParcG PF10274.4 AMD20039.1 - 0.0073 16.2 0.5 2.6 7.9 0.0 2.6 2 0 0 2 2 2 1 Parkin co-regulated protein UME PF08064.8 AMD20039.1 - 0.009 15.9 0.7 0.03 14.2 0.5 1.9 1 0 0 1 1 1 1 UME (NUC010) domain Mg_chelatase PF01078.16 AMD20039.1 - 0.011 14.8 0.3 1.9 7.6 0.0 3.4 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI HEAT PF02985.17 AMD20039.1 - 0.015 15.3 1.7 49 4.3 0.0 5.0 5 0 0 5 5 3 0 HEAT repeat ATP_bind_1 PF03029.12 AMD20039.1 - 0.021 14.3 1.0 8 5.9 0.0 3.5 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.1 AMD20039.1 - 0.023 14.4 0.0 6 6.7 0.0 3.0 3 0 0 3 3 2 0 Part of AAA domain CRM1_C PF08767.6 AMD20039.1 - 0.03 13.2 0.0 0.058 12.3 0.0 1.3 1 0 0 1 1 1 0 CRM1 C terminal DUF3385 PF11865.3 AMD20039.1 - 0.031 14.2 0.3 7.1 6.5 0.3 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF3385) IstB_IS21 PF01695.12 AMD20039.1 - 0.036 13.4 0.0 15 4.9 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding protein Septin PF00735.13 AMD20039.1 - 0.039 12.9 0.0 1 8.2 0.0 2.4 2 0 0 2 2 2 0 Septin DUF87 PF01935.12 AMD20039.1 - 0.044 13.6 5.9 0.35 10.6 0.0 4.1 4 1 1 5 5 4 0 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 AMD20039.1 - 0.051 13.0 0.1 3.7 6.9 0.0 3.1 3 1 0 3 3 3 0 FtsK/SpoIIIE family NTPase_1 PF03266.10 AMD20039.1 - 0.061 13.0 0.1 15 5.2 0.0 2.8 2 0 0 2 2 2 0 NTPase Cnd1 PF12717.2 AMD20039.1 - 0.085 12.6 0.1 1.6 8.5 0.0 2.9 3 1 0 3 3 2 0 non-SMC mitotic condensation complex subunit 1 UPF0079 PF02367.12 AMD20039.1 - 0.1 12.2 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Pkinase PF00069.20 AMD20040.1 - 7.3e-58 195.7 0.0 1.1e-57 195.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20040.1 - 6.5e-23 81.1 0.0 3.5e-22 78.7 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20040.1 - 3.2e-05 23.0 0.1 0.047 12.6 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 AMD20040.1 - 0.0014 17.7 0.0 0.0024 16.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SNF2_N PF00176.18 AMD20041.1 - 1.6e-45 155.2 0.5 3.5e-45 154.0 0.3 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_2 PF13639.1 AMD20041.1 - 9e-10 38.2 7.4 2.6e-09 36.7 5.1 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 AMD20041.1 - 2.1e-09 36.8 9.0 5.5e-09 35.5 6.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD20041.1 - 1.5e-08 34.5 10.6 4.5e-08 32.9 7.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD20041.1 - 2.4e-08 33.5 6.7 5e-08 32.4 4.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 AMD20041.1 - 1.1e-05 25.3 7.5 5.6e-05 23.1 5.2 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 AMD20041.1 - 2.6e-05 23.8 8.2 5.8e-05 22.7 5.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Helicase_C PF00271.26 AMD20041.1 - 0.00029 20.6 0.0 0.00094 19.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_4 PF15227.1 AMD20041.1 - 0.00047 19.9 10.1 0.0013 18.5 7.0 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 AMD20041.1 - 0.87 9.3 7.3 2.9 7.7 5.0 1.9 1 0 0 1 1 1 0 RING-type zinc-finger LisH PF08513.6 AMD20042.1 - 5.4e-08 32.3 1.7 9.8e-08 31.5 1.2 1.5 1 0 0 1 1 1 1 LisH LNS2 PF08235.8 AMD20043.1 - 2.6e-72 241.5 0.0 7.8e-72 239.9 0.0 1.8 2 0 0 2 2 2 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 AMD20043.1 - 9.1e-44 147.6 0.0 2.2e-43 146.4 0.0 1.7 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.9 AMD20043.1 - 0.022 14.1 0.0 0.12 11.7 0.0 2.1 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Spindle_Spc25 PF08234.7 AMD20043.1 - 0.046 13.7 0.1 0.47 10.4 0.0 2.4 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 Hydrolase_6 PF13344.1 AMD20043.1 - 0.063 13.1 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase AF1Q PF15017.1 AMD20043.1 - 0.11 12.4 0.2 0.11 12.4 0.2 2.9 3 0 0 3 3 3 0 Drug resistance and apoptosis regulator Mito_carr PF00153.22 AMD20044.1 - 2.4e-67 222.7 1.7 1.8e-23 82.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_M22 PF00814.20 AMD20045.1 - 1.2e-69 234.7 0.0 1.5e-69 234.4 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Nse4_C PF08743.5 AMD20046.1 - 6.6e-23 80.5 0.0 1.8e-22 79.1 0.0 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.1 AMD20046.1 - 6.2e-13 48.3 0.3 5.9e-11 42.0 0.1 2.5 2 0 0 2 2 2 2 Binding domain of Nse4/EID3 to Nse3-MAGE DNA_mis_repair PF01119.14 AMD20047.1 - 3.1e-29 100.8 1.1 5.8e-29 99.9 0.1 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 AMD20047.1 - 2e-13 50.1 0.2 7e-13 48.3 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 AMD20047.1 - 1.5e-08 34.3 0.1 9.4e-08 31.7 0.1 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3752 PF12572.3 AMD20047.1 - 0.25 11.4 5.1 0.43 10.7 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) Zn_clus PF00172.13 AMD20048.1 - 2.2e-07 30.6 11.3 4.8e-07 29.5 7.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.17 AMD20049.1 - 7.2e-161 535.6 0.0 8.1e-161 535.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 AMD20049.1 - 5.8e-05 21.9 0.0 0.0001 21.1 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF2963 PF11178.3 AMD20049.1 - 0.041 13.2 0.1 5.8 6.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2963) Homeobox PF00046.24 AMD20050.1 - 9.3e-20 70.0 2.8 1.8e-19 69.1 1.9 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 AMD20050.1 - 0.00043 19.9 0.9 0.0013 18.4 0.6 1.8 1 0 0 1 1 1 1 Homeobox KN domain SPRY PF00622.23 AMD20051.1 - 2.2e-15 56.8 0.1 5.8e-15 55.4 0.1 1.8 1 0 0 1 1 1 1 SPRY domain HECT PF00632.20 AMD20052.1 - 9.8e-84 281.1 1.6 1.8e-83 280.3 1.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.22 AMD20052.1 - 0.0043 16.5 0.5 0.0095 15.4 0.3 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Glyco_transf_22 PF03901.12 AMD20053.1 - 4.5e-94 315.8 34.8 6.1e-94 315.3 24.1 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family TPR_16 PF13432.1 AMD20054.1 - 1.1e-06 29.1 4.9 0.00072 20.1 0.2 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 AMD20054.1 - 2.6e-06 26.9 9.3 0.0047 16.5 0.2 3.6 2 2 1 3 3 3 3 TPR repeat TPR_19 PF14559.1 AMD20054.1 - 0.0014 18.9 3.2 0.095 13.0 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20054.1 - 0.003 17.3 7.9 3.8 7.6 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20054.1 - 0.016 14.9 14.8 2.2 8.2 0.1 6.0 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 AMD20054.1 - 0.036 14.0 6.4 2.1 8.3 0.1 4.1 2 2 1 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 AMD20054.1 - 0.24 12.1 10.8 1 10.1 0.4 4.2 5 0 0 5 5 5 0 Sel1 repeat Apc3 PF12895.2 AMD20054.1 - 0.71 10.0 5.1 1.4 9.1 0.1 3.2 2 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Pkinase PF00069.20 AMD20055.1 - 9.3e-69 231.4 0.0 1.1e-68 231.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20055.1 - 6e-31 107.4 0.0 7.5e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20055.1 - 0.00048 19.1 0.0 0.00068 18.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD20055.1 - 0.018 14.7 0.1 0.051 13.3 0.1 1.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 AMD20055.1 - 0.06 12.1 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 RF-1 PF00472.15 AMD20056.1 - 3.4e-40 136.4 4.2 8.4e-40 135.1 2.9 1.7 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.13 AMD20056.1 - 1e-32 112.2 0.1 5.8e-32 109.8 0.0 2.3 2 0 0 2 2 2 1 PCRF domain DUF4248 PF14053.1 AMD20056.1 - 0.02 14.4 0.1 0.069 12.7 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) Mating_N PF12731.2 AMD20056.1 - 0.068 13.0 0.1 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein beta 1 AAA_23 PF13476.1 AMD20056.1 - 0.22 11.8 3.7 11 6.3 1.1 2.4 2 0 0 2 2 2 0 AAA domain DUF676 PF05057.9 AMD20057.1 - 3.3e-56 190.0 0.0 5.3e-56 189.3 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 AMD20057.1 - 6.9e-05 22.4 0.0 0.00019 21.0 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 AMD20057.1 - 0.0019 17.8 0.0 0.0041 16.7 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 AMD20057.1 - 0.045 13.5 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family RINT1_TIP1 PF04437.8 AMD20058.1 - 2.9e-80 270.1 22.9 4.3e-80 269.6 15.9 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Noelin-1 PF12308.3 AMD20058.1 - 0.089 12.5 0.7 0.43 10.4 0.3 2.4 1 1 0 1 1 1 0 Neurogenesis glycoprotein Cep57_CLD_2 PF14197.1 AMD20058.1 - 0.4 10.6 4.0 0.62 10.0 1.4 2.4 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Osmo_CC PF08946.5 AMD20058.1 - 0.41 10.7 6.2 3.7 7.6 0.2 3.5 3 0 0 3 3 3 0 Osmosensory transporter coiled coil SNARE PF05739.14 AMD20058.1 - 1.7 8.4 5.9 3 7.6 0.1 3.3 4 0 0 4 4 4 0 SNARE domain Chorismate_synt PF01264.16 AMD20059.1 - 5.4e-133 442.7 0.0 6.2e-133 442.5 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase SH3_1 PF00018.23 AMD20060.1 - 1.3e-06 27.7 0.2 4e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 SH3 domain Transglut_core PF01841.14 AMD20060.1 - 0.0094 16.1 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.12 AMD20060.1 - 0.063 12.7 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Nup84_Nup100 PF04121.8 AMD20061.1 - 1.3e-214 713.9 18.0 1.5e-214 713.7 12.5 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Ribosomal_L6 PF00347.18 AMD20062.1 - 1.1e-30 105.9 10.8 5.4e-16 58.8 2.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 PC4 PF02229.11 AMD20062.1 - 0.092 11.9 1.6 0.18 11.0 0.0 2.2 3 0 0 3 3 3 0 Transcriptional Coactivator p15 (PC4) YbbR PF07949.7 AMD20062.1 - 0.48 10.5 3.7 5.1 7.2 1.1 3.1 1 1 1 2 2 2 0 YbbR-like protein DUF1762 PF08574.5 AMD20063.1 - 7.4e-20 71.1 9.0 7.4e-20 71.1 6.2 3.5 3 2 2 5 5 5 1 Protein of unknown function (DUF1762) adh_short PF00106.20 AMD20064.1 - 5.3e-27 94.7 0.0 9.1e-27 94.0 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AMD20064.1 - 4.3e-09 36.2 0.1 4.9e-08 32.8 0.1 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 AMD20064.1 - 0.00021 20.8 0.0 0.0003 20.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 AMD20064.1 - 0.00042 20.1 0.0 0.0006 19.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3Beta_HSD PF01073.14 AMD20064.1 - 0.0052 15.5 0.0 0.0075 15.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 AMD20064.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 NADH(P)-binding AXE1 PF05448.7 AMD20064.1 - 0.053 12.0 0.0 0.087 11.3 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) NAD_binding_4 PF07993.7 AMD20064.1 - 0.15 10.9 1.4 3.7 6.4 0.9 2.2 1 1 0 1 1 1 0 Male sterility protein PX PF00787.19 AMD20065.1 - 8.4e-21 73.8 0.4 2.5e-20 72.3 0.0 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 AMD20065.1 - 7.1e-06 25.4 11.9 3e-05 23.3 1.6 2.3 2 0 0 2 2 2 2 Vps5 C terminal like DUF3854 PF12965.2 AMD20065.1 - 0.04 13.5 0.1 0.086 12.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) TFIIE_alpha PF02002.12 AMD20065.1 - 0.11 12.0 3.0 11 5.5 0.2 3.3 2 1 1 3 3 3 0 TFIIE alpha subunit SpoU_methylase PF00588.14 AMD20066.1 - 2.2e-26 92.4 0.0 5.8e-26 91.0 0.0 1.8 1 0 0 1 1 1 1 SpoU rRNA Methylase family RNase_PH PF01138.16 AMD20067.1 - 2.7e-12 47.1 0.0 4.3e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 AMD20067.1 - 5.5e-05 23.0 0.2 0.00011 22.1 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 EMP24_GP25L PF01105.19 AMD20068.1 - 1.7e-06 27.9 0.0 2.2e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SNARE PF05739.14 AMD20069.1 - 0.017 14.8 1.3 0.094 12.4 0.0 2.3 2 0 0 2 2 2 0 SNARE domain DUF3847 PF12958.2 AMD20069.1 - 0.035 13.8 2.8 0.82 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) ISG65-75 PF11727.3 AMD20069.1 - 0.14 11.1 0.4 0.15 11.0 0.3 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Paralemmin PF03285.10 AMD20069.1 - 4.6 6.6 6.6 2 7.8 0.9 2.0 1 1 1 2 2 2 0 Paralemmin SNF2_N PF00176.18 AMD20070.1 - 2.5e-70 236.6 1.0 2.5e-70 236.6 0.7 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.1 AMD20070.1 - 4.6e-53 179.0 23.3 4.6e-53 179.0 16.1 5.2 6 0 0 6 6 6 1 DNA-binding domain Helicase_C PF00271.26 AMD20070.1 - 1.1e-13 50.8 0.0 3.3e-13 49.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Med5 PF08689.5 AMD20071.1 - 3.1e-231 770.0 36.7 3.5e-231 769.8 25.4 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 ParBc_2 PF08857.6 AMD20071.1 - 0.013 15.2 0.2 0.027 14.3 0.1 1.5 1 0 0 1 1 1 0 Putative ParB-like nuclease Pex14_N PF04695.8 AMD20072.1 - 3.3e-34 117.8 1.4 3.3e-34 117.8 1.0 3.2 3 1 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Ead_Ea22 PF13935.1 AMD20072.1 - 0.00051 20.3 2.6 0.00051 20.3 1.8 1.8 2 0 0 2 2 1 1 Ead/Ea22-like protein MCPsignal PF00015.16 AMD20072.1 - 0.0015 18.0 1.8 0.0022 17.5 0.2 1.8 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain TMF_DNA_bd PF12329.3 AMD20072.1 - 0.0041 16.8 13.1 0.0041 16.8 9.1 3.4 4 0 0 4 4 3 1 TATA element modulatory factor 1 DNA binding DUF3584 PF12128.3 AMD20072.1 - 0.0084 13.5 8.7 0.012 13.0 6.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) SF-assemblin PF06705.6 AMD20072.1 - 0.014 14.5 10.2 0.029 13.5 7.1 1.4 1 0 0 1 1 1 0 SF-assemblin/beta giardin DUF1043 PF06295.7 AMD20072.1 - 0.02 14.5 1.9 0.02 14.5 1.3 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) Reo_sigmaC PF04582.7 AMD20072.1 - 0.033 13.3 0.7 0.052 12.7 0.5 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF2937 PF11157.3 AMD20072.1 - 0.083 12.2 0.1 0.19 11.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) DUF1664 PF07889.7 AMD20072.1 - 0.084 12.6 8.9 0.097 12.4 3.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.6 AMD20072.1 - 0.18 10.4 12.5 0.45 9.1 8.7 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein MbeD_MobD PF04899.7 AMD20072.1 - 0.29 11.0 6.4 0.13 12.2 1.9 2.3 2 1 1 3 3 3 0 MbeD/MobD like Myosin_tail_1 PF01576.14 AMD20072.1 - 0.31 8.6 21.2 0.019 12.7 10.2 1.9 2 0 0 2 2 2 0 Myosin tail Phage_Mu_Gam PF07352.7 AMD20072.1 - 0.47 9.9 11.0 1.3 8.5 7.6 1.7 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Cortex-I_coil PF09304.5 AMD20072.1 - 1.9 8.5 16.4 14 5.7 11.4 2.3 1 1 0 1 1 1 0 Cortexillin I, coiled coil Seryl_tRNA_N PF02403.17 AMD20072.1 - 2.6 8.1 19.6 0.44 10.5 8.4 3.0 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.6 AMD20072.1 - 3 7.7 7.5 1.9 8.4 1.3 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) FlgN PF05130.7 AMD20072.1 - 3.5 7.8 19.4 0.54 10.5 9.7 2.2 2 0 0 2 2 2 0 FlgN protein Laminin_II PF06009.7 AMD20072.1 - 4.4 7.0 15.7 0.24 11.1 6.4 2.2 3 0 0 3 3 3 0 Laminin Domain II DUF641 PF04859.7 AMD20072.1 - 4.6 7.0 11.9 0.69 9.6 5.1 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Tweety PF04906.8 AMD20072.1 - 6 5.1 6.3 1.6 7.0 2.3 1.5 2 0 0 2 2 2 0 Tweety V_ATPase_I PF01496.14 AMD20072.1 - 6.3 4.5 7.1 9.2 3.9 4.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.7 AMD20072.1 - 7.5 6.8 9.0 6.2 7.1 2.4 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ISG65-75 PF11727.3 AMD20072.1 - 9.3 5.1 11.0 1.6 7.6 4.8 1.7 2 0 0 2 2 2 0 Invariant surface glycoprotein ACPS PF01648.15 AMD20073.1 - 3e-13 49.6 0.0 1.9e-11 43.8 0.0 2.4 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase superfamily BPL_N PF09825.4 AMD20074.1 - 1.3e-112 376.2 0.0 1.6e-112 375.9 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_C PF02237.12 AMD20074.1 - 1.7e-10 40.4 0.0 3.4e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain BPL_LplA_LipB PF03099.14 AMD20074.1 - 3.6e-10 39.9 0.0 1.5e-09 37.8 0.0 2.0 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family RNA_pol_Rpb1_1 PF04997.7 AMD20075.1 - 8.7e-120 400.0 0.0 1.9e-119 398.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 AMD20075.1 - 5e-109 363.8 0.2 8.5e-109 363.0 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 AMD20075.1 - 6.8e-73 244.0 0.0 1.7e-72 242.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 AMD20075.1 - 7.3e-63 211.6 0.5 7.3e-63 211.6 0.4 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 AMD20075.1 - 2e-48 164.0 0.0 1.1e-47 161.6 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 AMD20075.1 - 1.5e-46 157.4 3.3 3.2e-46 156.3 2.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 AMD20075.1 - 1.1e-35 121.6 0.1 2.9e-35 120.2 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 AMD20075.1 - 2.5e-15 55.1 273.7 0.045 13.8 9.2 14.3 4 1 14 21 21 21 20 RNA polymerase Rpb1 C-terminal repeat Pro_isomerase PF00160.16 AMD20076.1 - 2.6e-47 160.8 0.1 4.1e-47 160.2 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 AMD20076.1 - 4.3e-09 35.9 5.4 0.00014 21.3 0.8 2.4 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 AMD20076.1 - 4.7e-08 32.3 2.4 1.1e-05 24.8 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20076.1 - 1.5e-07 30.8 4.2 0.00014 21.4 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20076.1 - 0.0022 17.6 1.3 0.0049 16.5 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 AMD20076.1 - 0.004 16.9 1.1 0.0082 15.9 0.7 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 AMD20076.1 - 0.11 13.0 6.4 0.11 13.0 0.1 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 AMD20076.1 - 0.34 11.0 3.4 0.55 10.4 1.2 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Scm3 PF10384.4 AMD20077.1 - 2.6e-21 74.8 0.4 5.7e-21 73.7 0.3 1.6 1 0 0 1 1 1 1 Centromere protein Scm3 Nop14 PF04147.7 AMD20077.1 - 2.9 5.7 15.5 3 5.6 10.8 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4637 PF15470.1 AMD20077.1 - 5.6 6.5 10.1 1.6 8.3 4.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) CHCH PF06747.8 AMD20078.1 - 0.0018 18.1 2.9 0.0033 17.3 2.0 1.5 1 0 0 1 1 1 1 CHCH domain Sec31 PF11549.3 AMD20079.1 - 1.7e-22 78.8 1.7 1.7e-22 78.8 1.2 2.4 2 0 0 2 2 2 1 Protein transport protein SEC31 WD40 PF00400.27 AMD20079.1 - 7.3e-19 66.8 6.1 1.5e-05 24.6 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat SRA1 PF07304.6 AMD20079.1 - 3.3e-11 43.1 0.0 3.9e-10 39.6 0.0 2.7 2 0 0 2 2 2 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.2 AMD20079.1 - 5.9e-05 22.9 0.4 0.00014 21.7 0.3 1.6 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Prp18 PF02840.10 AMD20079.1 - 0.025 14.4 0.4 0.13 12.0 0.3 2.1 1 1 0 1 1 1 0 Prp18 domain Trp_dioxygenase PF03301.8 AMD20079.1 - 0.032 13.3 0.1 0.077 12.0 0.1 1.5 1 0 0 1 1 1 0 Tryptophan 2,3-dioxygenase Prenyltransf PF01255.14 AMD20080.1 - 9.7e-06 24.8 0.0 8.5e-05 21.7 0.0 2.1 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF1003 PF06210.6 AMD20080.1 - 0.045 13.6 0.1 0.088 12.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Arf PF00025.16 AMD20081.1 - 1.8e-30 105.4 0.0 2.2e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 AMD20081.1 - 2.8e-05 24.5 0.0 9.6e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 AMD20081.1 - 0.0015 18.5 0.0 0.028 14.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 AMD20081.1 - 0.0089 15.4 0.0 0.027 13.8 0.0 1.7 1 1 0 1 1 1 1 Ras family SRPRB PF09439.5 AMD20081.1 - 0.012 14.7 0.0 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MutS_V PF00488.16 AMD20081.1 - 0.047 13.0 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 MutS domain V AAA_18 PF13238.1 AMD20081.1 - 0.11 12.7 0.1 0.39 11.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 AMD20081.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Arf PF00025.16 AMD20082.1 - 2.1e-79 264.8 0.0 2.4e-79 264.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 AMD20082.1 - 7e-15 54.7 0.0 8.6e-15 54.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 AMD20082.1 - 6.4e-14 51.6 0.0 6.9e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 AMD20082.1 - 1.7e-12 46.7 1.1 1e-09 37.5 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 AMD20082.1 - 8.7e-12 44.6 0.0 1.1e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 AMD20082.1 - 3.7e-11 43.5 0.0 4.8e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 AMD20082.1 - 7e-06 25.9 0.0 9.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD20082.1 - 0.0046 16.4 0.1 0.021 14.2 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRP54 PF00448.17 AMD20082.1 - 0.006 16.0 0.5 0.011 15.1 0.1 1.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.1 AMD20082.1 - 0.0072 16.2 0.1 0.012 15.4 0.1 1.6 1 1 0 1 1 1 1 AAA domain cobW PF02492.14 AMD20082.1 - 0.023 14.1 0.3 6.3 6.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 AMD20082.1 - 0.027 14.1 0.7 3 7.4 0.0 2.1 2 0 0 2 2 2 0 NACHT domain 6PF2K PF01591.13 AMD20082.1 - 0.061 12.3 1.1 0.29 10.1 0.8 1.9 1 1 0 1 1 1 0 6-phosphofructo-2-kinase CW_binding_2 PF04122.7 AMD20082.1 - 0.074 13.2 0.0 0.19 11.9 0.0 1.6 2 0 0 2 2 1 0 Putative cell wall binding repeat 2 DBD_Tnp_Mut PF03108.10 AMD20082.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 MuDR family transposase ABC_tran PF00005.22 AMD20082.1 - 0.11 12.7 0.1 0.25 11.6 0.1 1.7 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.4 AMD20082.1 - 0.12 11.9 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Thymidylate_kin PF02223.12 AMD20082.1 - 0.17 11.2 1.0 0.91 8.8 0.2 2.0 2 0 0 2 2 2 0 Thymidylate kinase AAA_17 PF13207.1 AMD20082.1 - 0.25 12.1 1.1 0.9 10.3 0.8 1.8 1 1 0 1 1 1 0 AAA domain Ribosomal_L29 PF00831.18 AMD20083.1 - 4.4e-17 61.4 2.4 4.4e-17 61.4 1.7 2.3 2 1 0 2 2 2 1 Ribosomal L29 protein Annexin PF00191.15 AMD20083.1 - 0.11 12.3 0.5 0.19 11.6 0.1 1.7 2 0 0 2 2 2 0 Annexin IL2 PF00715.12 AMD20083.1 - 0.14 11.8 2.1 0.17 11.5 1.3 1.4 1 1 0 1 1 1 0 Interleukin 2 Snapin_Pallidin PF14712.1 AMD20083.1 - 0.23 11.8 5.1 0.51 10.6 3.6 1.6 1 0 0 1 1 1 0 Snapin/Pallidin MRP-L47 PF06984.8 AMD20083.1 - 0.24 11.3 2.6 0.45 10.4 0.6 2.2 1 1 1 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF4404 PF14357.1 AMD20083.1 - 0.28 11.6 2.3 1.1 9.6 1.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) Med10 PF09748.4 AMD20083.1 - 0.6 9.9 4.2 4.4 7.1 2.6 2.1 1 1 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex DUF4600 PF15372.1 AMD20083.1 - 0.71 10.0 8.8 2.4 8.3 6.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) Ufd2P_core PF10408.4 AMD20084.1 - 3.6e-189 630.0 16.4 3.6e-189 630.0 11.4 1.7 2 0 0 2 2 2 1 Ubiquitin elongating factor core U-box PF04564.10 AMD20084.1 - 1.7e-29 101.5 1.5 4.7e-29 100.1 1.0 1.8 1 0 0 1 1 1 1 U-box domain DUF2279 PF10043.4 AMD20084.1 - 0.041 14.1 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2279) Rho_GDI PF02115.12 AMD20085.1 - 1.1e-63 214.2 1.4 1.4e-63 213.9 1.0 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.23 AMD20086.1 - 2.7e-39 134.6 0.3 3.6e-39 134.2 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ATP-synt_ab PF00006.20 AMD20088.1 - 8.7e-119 394.7 0.0 1.3e-118 394.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Hom_end_hint PF05203.11 AMD20088.1 - 2.2e-61 207.3 0.0 3.3e-61 206.7 0.0 1.3 1 0 0 1 1 1 1 Hom_end-associated Hint ATP-synt_ab_C PF00306.22 AMD20088.1 - 1.5e-19 70.4 0.1 3.9e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 AMD20088.1 - 8.6e-16 57.9 3.1 2.2e-15 56.6 2.1 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Hom_end PF05204.9 AMD20088.1 - 1.1e-10 41.3 0.1 1.7e-09 37.5 0.0 2.4 2 0 0 2 2 2 1 Homing endonuclease Hint PF01079.15 AMD20088.1 - 0.00039 19.7 0.0 0.00095 18.4 0.0 1.6 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.1 AMD20088.1 - 0.00057 19.8 0.0 0.0015 18.4 0.0 1.7 1 0 0 1 1 1 1 Hint domain Ribosomal_L41 PF05162.8 AMD20089.1 - 9.5e-09 34.7 25.2 1e-08 34.7 17.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L41 DUF1601 PF07671.6 AMD20089.1 - 0.18 11.4 1.3 0.2 11.3 0.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1601) Mit_KHE1 PF10173.4 AMD20090.1 - 5.8e-54 182.7 4.8 5.8e-54 182.7 3.4 1.4 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related Peptidase_S49_N PF08496.5 AMD20090.1 - 2 8.1 5.4 4.3 7.1 3.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MARVEL PF01284.18 AMD20091.1 - 0.005 16.6 2.5 0.0082 15.9 1.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF3671 PF12420.3 AMD20091.1 - 0.083 12.8 3.6 0.098 12.6 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function PBP1_TM PF14812.1 AMD20091.1 - 2.7 8.3 6.1 1.9 8.8 1.5 2.7 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cullin PF00888.17 AMD20092.1 - 4.8e-154 514.1 16.9 6.3e-154 513.7 11.7 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 AMD20092.1 - 5.1e-25 87.0 0.8 2e-24 85.1 0.5 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain Penicillinase_R PF03965.11 AMD20092.1 - 0.035 14.1 0.1 0.35 10.9 0.0 2.7 2 0 0 2 2 2 0 Penicillinase repressor HMGL-like PF00682.14 AMD20093.1 - 4.3e-73 245.8 0.1 7.2e-73 245.1 0.1 1.3 1 0 0 1 1 1 1 HMGL-like IATP PF04568.7 AMD20094.1 - 2.7e-19 69.0 1.6 2.9e-19 68.9 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Fib_alpha PF08702.5 AMD20094.1 - 0.005 16.9 2.3 0.0053 16.8 1.6 1.1 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family AAA_23 PF13476.1 AMD20094.1 - 0.021 15.1 4.0 0.021 15.1 2.8 1.0 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 AMD20094.1 - 0.023 14.3 2.1 0.02 14.4 1.4 1.1 1 0 0 1 1 1 0 IncA protein YflT PF11181.3 AMD20094.1 - 0.05 13.7 0.8 0.058 13.5 0.6 1.2 1 0 0 1 1 1 0 Heat induced stress protein YflT Atg14 PF10186.4 AMD20094.1 - 0.051 12.5 3.2 0.051 12.5 2.2 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Gal4_dimer PF03902.8 AMD20094.1 - 0.062 13.2 0.5 0.11 12.4 0.4 1.5 1 0 0 1 1 1 0 Gal4-like dimerisation domain TCTP PF00838.12 AMD20094.1 - 0.13 12.2 0.9 0.14 12.1 0.6 1.1 1 0 0 1 1 1 0 Translationally controlled tumour protein DUF4140 PF13600.1 AMD20094.1 - 0.22 12.0 2.2 0.25 11.8 1.5 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Ribosomal_L6e PF01159.14 AMD20094.1 - 0.45 10.7 3.9 0.51 10.6 2.7 1.1 1 0 0 1 1 1 0 Ribosomal protein L6e PspB PF06667.7 AMD20094.1 - 0.46 10.4 5.5 0.6 10.0 3.8 1.1 1 0 0 1 1 1 0 Phage shock protein B FYVE_2 PF02318.11 AMD20094.1 - 0.93 9.4 4.7 1.1 9.2 3.3 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger Bap31 PF05529.7 AMD20094.1 - 2.2 7.7 7.5 2.5 7.5 5.2 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DASH_Dad2 PF08654.5 AMD20094.1 - 3.6 7.6 7.1 5.4 7.0 5.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad2 DivIC PF04977.10 AMD20094.1 - 4.9 6.7 10.0 4.8 6.7 6.4 1.4 1 1 0 1 1 1 0 Septum formation initiator Ribosomal_60s PF00428.14 AMD20095.1 - 2.7e-22 78.9 9.7 3.2e-22 78.7 6.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF4644 PF15486.1 AMD20096.1 - 0.02 14.8 0.8 0.02 14.8 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4644) Myc-LZ PF02344.10 AMD20096.1 - 0.04 13.5 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 Myc leucine zipper domain Na_Ca_ex PF01699.19 AMD20098.1 - 1.3e-48 164.1 33.5 1.2e-25 89.7 5.9 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Cyclin_N PF00134.18 AMD20099.1 - 1.1e-15 57.3 0.0 1.5e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 AMD20099.1 - 5.4e-11 43.1 0.0 8e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin AAA PF00004.24 AMD20100.1 - 1.7e-98 325.9 0.0 2.4e-48 163.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 AMD20100.1 - 2.5e-18 65.7 0.7 7.5e-18 64.2 0.2 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 AMD20100.1 - 1.7e-13 50.8 0.0 4.9e-07 29.8 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 AMD20100.1 - 2.1e-13 49.8 0.0 1.5e-05 24.1 0.0 2.9 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 AMD20100.1 - 1.5e-12 47.4 1.6 3e-06 27.0 0.0 3.9 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 AMD20100.1 - 1.2e-11 44.8 0.3 0.0011 19.0 0.0 3.9 3 2 1 4 4 3 2 AAA ATPase domain AAA_33 PF13671.1 AMD20100.1 - 1.9e-11 44.0 0.0 8.9e-06 25.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 AMD20100.1 - 2.7e-11 44.3 0.0 0.0011 19.7 0.0 3.9 4 0 0 4 4 2 2 AAA domain AAA_22 PF13401.1 AMD20100.1 - 2.6e-10 40.5 3.8 0.0012 18.9 0.1 4.4 3 2 0 3 3 2 2 AAA domain CDC48_2 PF02933.12 AMD20100.1 - 2e-09 36.9 0.1 1.6e-08 34.0 0.0 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.8 AMD20100.1 - 2.2e-09 36.5 0.2 0.0014 17.4 0.0 2.6 3 0 0 3 3 2 2 TIP49 C-terminus AAA_14 PF13173.1 AMD20100.1 - 5.5e-09 35.9 0.0 0.0028 17.5 0.0 3.6 4 0 0 4 4 4 2 AAA domain IstB_IS21 PF01695.12 AMD20100.1 - 6.8e-08 32.1 0.1 0.0071 15.7 0.0 2.9 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_25 PF13481.1 AMD20100.1 - 9.9e-08 31.6 6.2 0.0027 17.1 0.2 4.3 2 2 1 3 3 3 2 AAA domain RNA_helicase PF00910.17 AMD20100.1 - 2.1e-07 31.0 0.0 0.0099 16.0 0.0 3.1 3 0 0 3 3 2 2 RNA helicase AAA_19 PF13245.1 AMD20100.1 - 2.6e-07 30.2 1.0 0.024 14.3 0.0 3.0 2 0 0 2 2 2 2 Part of AAA domain Mg_chelatase PF01078.16 AMD20100.1 - 3.3e-07 29.6 0.4 0.027 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 AMD20100.1 - 6.4e-07 28.6 0.0 0.0078 15.3 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_24 PF13479.1 AMD20100.1 - 2.3e-06 27.3 0.1 0.11 12.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain KaiC PF06745.8 AMD20100.1 - 4.1e-06 26.0 3.1 0.26 10.3 0.0 3.8 2 2 1 3 3 3 2 KaiC AAA_28 PF13521.1 AMD20100.1 - 5.9e-06 26.3 0.1 0.25 11.3 0.0 3.3 3 0 0 3 3 3 2 AAA domain ResIII PF04851.10 AMD20100.1 - 7.1e-06 25.9 0.0 0.0062 16.3 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.21 AMD20100.1 - 1e-05 25.0 0.1 0.11 11.9 0.0 3.5 3 1 0 3 3 2 2 Sigma-54 interaction domain PhoH PF02562.11 AMD20100.1 - 1.2e-05 24.6 0.2 0.098 11.8 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein ABC_tran PF00005.22 AMD20100.1 - 1.3e-05 25.4 0.1 0.023 15.0 0.0 3.6 3 1 0 3 3 2 1 ABC transporter AAA_18 PF13238.1 AMD20100.1 - 1.4e-05 25.3 0.0 0.19 12.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.12 AMD20100.1 - 3.2e-05 22.9 0.1 0.11 11.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.1 AMD20100.1 - 3.6e-05 23.8 0.0 0.16 12.0 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Vps4_C PF09336.5 AMD20100.1 - 5.6e-05 22.9 0.3 0.00072 19.3 0.1 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain DUF815 PF05673.8 AMD20100.1 - 6.6e-05 21.9 0.0 0.11 11.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 AMD20100.1 - 0.00011 21.9 0.2 0.5 10.0 0.1 3.8 2 2 1 3 3 3 1 Archaeal ATPase AAA_3 PF07726.6 AMD20100.1 - 0.00012 21.6 0.0 0.67 9.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 AMD20100.1 - 0.00012 21.6 0.0 0.46 10.0 0.0 2.6 2 1 0 2 2 2 2 AAA domain Bac_DnaA PF00308.13 AMD20100.1 - 0.00014 21.6 0.0 0.2 11.2 0.0 2.9 3 0 0 3 3 2 1 Bacterial dnaA protein NACHT PF05729.7 AMD20100.1 - 0.00027 20.6 0.2 1.7 8.3 0.0 3.5 3 0 0 3 3 3 1 NACHT domain DUF2075 PF09848.4 AMD20100.1 - 0.00051 19.1 0.0 0.69 8.8 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 AMD20100.1 - 0.0025 17.4 2.3 1.7 8.1 0.0 3.2 3 0 0 3 3 3 2 AAA domain NB-ARC PF00931.17 AMD20100.1 - 0.0046 15.8 0.2 1.8 7.3 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain KAP_NTPase PF07693.9 AMD20100.1 - 0.013 14.4 0.2 1.7 7.5 0.0 2.9 2 2 1 3 3 3 0 KAP family P-loop domain IPT PF01745.11 AMD20100.1 - 0.014 14.5 0.1 1.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase NTPase_1 PF03266.10 AMD20100.1 - 0.018 14.7 1.3 3.3 7.3 0.0 3.7 4 0 0 4 4 3 0 NTPase Zot PF05707.7 AMD20100.1 - 0.021 14.3 0.3 6.2 6.2 0.0 3.6 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) SKI PF01202.17 AMD20100.1 - 0.039 13.8 0.2 4.7 7.0 0.0 3.0 3 0 0 3 3 2 0 Shikimate kinase UPF0079 PF02367.12 AMD20100.1 - 0.04 13.5 0.1 6 6.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 AMD20100.1 - 0.052 12.4 0.0 2.9 6.7 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein DEAD PF00270.24 AMD20100.1 - 0.092 12.2 0.3 23 4.3 0.0 3.4 3 1 0 4 4 3 0 DEAD/DEAH box helicase Viral_helicase1 PF01443.13 AMD20100.1 - 0.12 11.8 0.0 16 4.9 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase KTI12 PF08433.5 AMD20100.1 - 0.12 11.5 0.1 13 4.9 0.0 2.7 2 1 0 2 2 2 0 Chromatin associated protein KTI12 HIT PF01230.18 AMD20101.1 - 5.1e-24 84.6 0.0 6.7e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 AMD20101.1 - 1.7e-09 37.8 0.4 3.4e-09 36.9 0.0 1.6 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding AA_permease PF00324.16 AMD20102.1 - 2.3e-115 385.6 35.7 2.8e-115 385.3 24.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD20102.1 - 1e-24 86.8 38.6 1.3e-24 86.5 26.7 1.1 1 0 0 1 1 1 1 Amino acid permease MgtE PF01769.11 AMD20102.1 - 0.28 11.4 0.0 0.28 11.4 0.0 3.4 4 0 0 4 4 4 0 Divalent cation transporter FAD-oxidase_C PF02913.14 AMD20103.1 - 5.3e-56 189.6 0.0 6.9e-56 189.3 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 AMD20103.1 - 1.2e-35 122.0 0.6 2.8e-35 120.8 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain UPF0029 PF01205.14 AMD20104.1 - 1.6e-29 101.8 0.0 2.2e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Pmp3 PF01679.12 AMD20106.1 - 3.4e-17 61.8 7.5 4.5e-17 61.4 5.2 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator P3A PF08727.6 AMD20106.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Poliovirus 3A protein like MAM33 PF02330.11 AMD20107.1 - 4.9e-44 150.5 5.5 5.7e-44 150.3 3.8 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein F-actin_cap_A PF01267.12 AMD20107.1 - 0.0073 15.3 0.9 0.012 14.6 0.6 1.4 1 0 0 1 1 1 1 F-actin capping protein alpha subunit PPR_2 PF13041.1 AMD20108.1 - 1.3e-08 34.7 6.4 2.5e-08 33.7 0.0 3.6 4 0 0 4 4 4 1 PPR repeat family PCI PF01399.22 AMD20109.1 - 0.049 13.9 3.7 0.05 13.9 0.6 2.4 2 1 0 2 2 2 0 PCI domain Coat_F PF07875.7 AMD20109.1 - 0.18 11.9 1.0 0.31 11.1 0.1 1.9 2 0 0 2 2 2 0 Coat F domain Peptidase_M24 PF00557.19 AMD20110.1 - 4.9e-50 169.9 0.0 7e-50 169.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 AMD20110.1 - 2.1e-29 101.6 0.0 3.9e-29 100.7 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NAD_binding_8 PF13450.1 AMD20110.1 - 0.065 13.2 0.1 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HORMA PF02301.13 AMD20111.1 - 2.8e-54 183.7 0.1 5.9e-54 182.7 0.1 1.6 1 0 0 1 1 1 1 HORMA domain PHD_2 PF13831.1 AMD20111.1 - 0.0049 16.1 3.9 0.011 15.0 2.7 1.6 1 0 0 1 1 1 1 PHD-finger PHD PF00628.24 AMD20111.1 - 2.3 7.9 10.7 5 6.9 7.4 1.5 1 0 0 1 1 1 0 PHD-finger Cnd1 PF12717.2 AMD20112.1 - 4.7e-54 182.9 20.0 2.6e-51 174.0 0.7 5.7 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.2 AMD20112.1 - 1.7e-41 141.7 2.7 1.7e-40 138.4 0.3 3.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_2 PF13646.1 AMD20112.1 - 2e-16 60.0 0.0 3.8e-06 27.0 0.1 5.0 3 2 2 5 5 5 4 HEAT repeats HEAT PF02985.17 AMD20112.1 - 6.4e-12 44.4 5.5 0.061 13.4 0.0 7.2 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.1 AMD20112.1 - 4.9e-09 36.4 0.6 0.049 14.1 0.0 6.4 7 0 0 7 7 7 2 HEAT-like repeat Cnd3 PF12719.2 AMD20112.1 - 9.5e-06 24.7 5.7 0.00055 19.0 0.7 4.1 3 1 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain DUF2435 PF10363.4 AMD20112.1 - 0.0035 17.2 4.4 16 5.4 0.0 5.3 4 2 1 5 5 5 1 Protein of unknown function (DUF2435) Cohesin_HEAT PF12765.2 AMD20112.1 - 0.0069 16.3 0.7 6.2 6.8 0.0 3.7 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion DUF482 PF04339.7 AMD20112.1 - 0.096 11.5 0.0 0.19 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF482 Ferrochelatase PF00762.14 AMD20113.1 - 5.2e-91 304.9 0.0 6.2e-91 304.6 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase MBOAT PF03062.14 AMD20114.1 - 2.8e-45 154.8 4.2 2.8e-45 154.8 2.9 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF1925 PF09094.6 AMD20114.1 - 0.038 13.9 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) Med4 PF10018.4 AMD20115.1 - 3.4e-36 124.4 2.4 3.4e-36 124.4 1.7 1.6 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF4187 PF13821.1 AMD20116.1 - 3.5e-17 61.7 3.3 3.5e-17 61.7 2.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.18 AMD20116.1 - 2e-05 24.2 0.8 3.9e-05 23.3 0.5 1.4 1 0 0 1 1 1 1 G-patch domain AvrPtoB-E3_ubiq PF09046.5 AMD20116.1 - 0.026 14.5 0.3 4 7.4 0.0 2.3 2 0 0 2 2 2 0 AvrPtoB E3 ubiquitin ligase zinc_ribbon_2 PF13240.1 AMD20116.1 - 0.11 12.0 0.5 0.25 10.8 0.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain DcpS PF05652.7 AMD20117.1 - 2.2e-37 127.8 0.2 3.1e-37 127.3 0.1 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.3 AMD20117.1 - 2.2e-31 108.4 0.0 4.2e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 AMD20117.1 - 0.0078 16.7 0.1 0.028 14.9 0.0 1.9 2 0 0 2 2 2 1 HIT domain DUF977 PF06163.6 AMD20117.1 - 0.098 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) Longin PF13774.1 AMD20118.1 - 2.7e-21 74.8 0.3 4.2e-21 74.2 0.2 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 AMD20118.1 - 1.5e-14 53.3 0.0 2.9e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin NUDIX PF00293.23 AMD20119.1 - 2.1e-15 56.5 0.1 2.4e-15 56.3 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain DUF410 PF04190.8 AMD20120.1 - 3.1e-65 220.2 0.3 3.7e-65 220.0 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) SNAP PF14938.1 AMD20120.1 - 0.0077 15.4 1.0 0.098 11.7 0.1 2.3 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP RHD3 PF05879.7 AMD20121.1 - 6.6e-228 758.3 26.4 8.3e-228 758.0 18.3 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.18 AMD20121.1 - 1.8e-05 24.6 0.3 8e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 AMD20121.1 - 3.7e-05 23.6 0.0 3.7e-05 23.6 0.0 2.8 3 0 0 3 3 3 1 Dynamin family Septin PF00735.13 AMD20121.1 - 0.00013 21.0 0.1 0.00042 19.4 0.0 1.8 1 0 0 1 1 1 1 Septin Miro PF08477.8 AMD20121.1 - 0.00036 21.0 0.1 0.002 18.5 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein AAA_28 PF13521.1 AMD20121.1 - 0.018 14.9 0.0 0.053 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 AMD20121.1 - 0.081 12.4 0.0 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 AMD20121.1 - 0.16 12.1 3.0 2 8.5 0.0 3.7 2 2 3 5 5 5 0 AAA domain ABC_tran PF00005.22 AMD20121.1 - 0.22 11.8 2.2 0.63 10.3 0.0 2.6 3 0 0 3 3 3 0 ABC transporter Prismane PF03063.15 AMD20121.1 - 0.29 9.4 1.4 0.64 8.3 0.0 2.0 2 0 0 2 2 2 0 Prismane/CO dehydrogenase family XLF PF09302.6 AMD20122.1 - 0.058 13.1 0.3 0.17 11.6 0.1 1.9 2 0 0 2 2 2 0 XLF (XRCC4-like factor) PIN_4 PF13638.1 AMD20123.1 - 1.7e-31 109.1 0.2 4.7e-31 107.6 0.0 1.8 2 0 0 2 2 2 1 PIN domain Ribosomal_S28e PF01200.13 AMD20124.1 - 9.8e-34 114.9 2.6 1e-33 114.8 1.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Red1 PF07964.6 AMD20125.1 - 6e-154 513.9 36.0 1.3e-153 512.8 25.0 1.5 1 1 0 1 1 1 1 Rec10 / Red1 tRNA-synt_1c PF00749.16 AMD20126.1 - 1.4e-111 372.1 0.0 2.1e-111 371.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.10 AMD20126.1 - 1.5e-55 187.1 1.5 2.7e-55 186.3 1.0 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.13 AMD20126.1 - 4e-34 117.7 0.0 2.9e-32 111.7 0.0 2.4 1 1 1 2 2 2 2 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.10 AMD20126.1 - 8.3e-22 77.6 2.9 8.7e-22 77.6 0.9 1.9 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TMA7 PF09072.5 AMD20127.1 - 7.2e-25 87.2 17.4 7.9e-25 87.1 12.1 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Ras PF00071.17 AMD20128.1 - 3.1e-54 182.7 1.9 3.6e-54 182.5 1.4 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD20128.1 - 6.6e-20 71.7 0.2 2e-19 70.2 0.0 1.7 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 AMD20128.1 - 6.1e-17 61.4 0.9 9e-17 60.8 0.6 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD20128.1 - 2e-06 27.3 0.1 3e-05 23.5 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD20128.1 - 9.5e-06 25.5 0.1 2.4e-05 24.2 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 AMD20128.1 - 1.2e-05 24.5 0.3 1.5e-05 24.2 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 AMD20128.1 - 0.00058 19.1 0.0 0.0011 18.1 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arch_ATPase PF01637.13 AMD20128.1 - 0.0099 15.6 0.1 0.019 14.6 0.1 1.6 1 1 0 1 1 1 1 Archaeal ATPase DAGK_cat PF00781.19 AMD20129.1 - 3.4e-25 87.9 0.0 5.7e-25 87.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain ATG22 PF11700.3 AMD20130.1 - 1.6e-95 320.3 23.7 1.9e-95 320.1 16.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like OapA_N PF08525.6 AMD20130.1 - 0.13 12.0 0.1 0.13 12.0 0.1 2.6 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif Cpn60_TCP1 PF00118.19 AMD20131.1 - 1.2e-117 393.5 9.1 1.4e-117 393.3 6.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RNA_pol_I_TF PF04090.7 AMD20132.1 - 9.1e-61 204.6 1.7 9.1e-61 204.6 1.2 1.8 2 0 0 2 2 2 1 RNA polymerase I specific initiation factor DAG1 PF05454.6 AMD20132.1 - 0.097 11.8 0.4 0.23 10.6 0.0 1.7 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) zf-RING_2 PF13639.1 AMD20133.1 - 2.9e-12 46.2 5.8 2.9e-12 46.2 4.0 1.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 AMD20133.1 - 1.2e-09 37.7 3.8 1.9e-09 37.0 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 AMD20133.1 - 9e-09 35.3 2.3 9e-09 35.3 1.6 1.9 2 0 0 2 2 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 AMD20133.1 - 2.3e-08 33.6 3.4 4.2e-08 32.7 2.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 AMD20133.1 - 1.5e-07 31.2 5.2 6.7e-07 29.2 3.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD20133.1 - 3.4e-06 26.5 6.1 7.8e-06 25.4 4.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 AMD20133.1 - 2.2e-05 24.0 4.4 0.00014 21.4 3.1 2.3 1 1 1 2 2 2 1 RING-type zinc-finger AKNA PF12443.3 AMD20133.1 - 0.0051 16.8 0.4 0.013 15.4 0.3 1.8 1 0 0 1 1 1 1 AT-hook-containing transcription factor HalX PF08663.5 AMD20133.1 - 0.0083 16.0 0.5 0.018 14.9 0.3 1.6 1 0 0 1 1 1 1 HalX domain Pox_A_type_inc PF04508.7 AMD20133.1 - 0.035 13.8 7.0 0.028 14.2 3.1 2.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat zf-Apc11 PF12861.2 AMD20133.1 - 0.045 13.5 3.8 0.16 11.8 2.6 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 AMD20133.1 - 0.057 12.9 1.0 0.12 11.9 0.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FANCL_C PF11793.3 AMD20133.1 - 0.085 12.8 3.1 0.51 10.3 2.2 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain TSC22 PF01166.13 AMD20133.1 - 0.22 11.5 3.0 0.63 10.0 1.2 2.4 1 1 1 2 2 2 0 TSC-22/dip/bun family TBPIP PF07106.8 AMD20133.1 - 0.29 10.6 7.4 0.026 14.0 1.3 1.9 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) zf-C3HC4_4 PF15227.1 AMD20133.1 - 0.44 10.4 5.5 0.089 12.6 0.9 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.9 AMD20133.1 - 1 8.8 6.2 0.3 10.5 1.5 2.1 2 0 0 2 2 2 0 P-11 zinc finger RINGv PF12906.2 AMD20133.1 - 1.1 9.4 5.4 4.2 7.4 3.8 2.0 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.1 AMD20133.1 - 1.5 8.4 4.0 3.4 7.3 2.8 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TMF_DNA_bd PF12329.3 AMD20133.1 - 6.3 6.6 11.2 0.26 11.1 1.9 2.7 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding OPA3 PF07047.7 AMD20134.1 - 1.1e-33 115.8 3.1 1.4e-33 115.5 2.1 1.0 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) HAMP PF00672.20 AMD20134.1 - 0.24 11.6 1.6 7.1 6.9 0.0 2.6 3 0 0 3 3 3 0 HAMP domain Histone PF00125.19 AMD20135.1 - 1.5e-22 79.4 0.1 1.9e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 AMD20135.1 - 0.00013 21.9 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF4 PF05236.9 AMD20136.1 - 3.4e-64 216.6 1.0 5.3e-64 216.0 0.7 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Vps4_C PF09336.5 AMD20136.1 - 0.053 13.4 0.0 0.19 11.6 0.0 1.9 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain RTC PF01137.16 AMD20137.1 - 5.4e-61 205.2 0.0 6.4e-61 205.0 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 AMD20137.1 - 9.1e-31 105.9 0.0 2.1e-30 104.7 0.0 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain PX PF00787.19 AMD20138.1 - 2.1e-20 72.6 0.4 5.5e-20 71.2 0.1 1.9 2 0 0 2 2 2 1 PX domain Latarcin PF10279.4 AMD20138.1 - 0.022 14.9 5.1 1.7 8.8 0.6 2.8 2 1 0 2 2 2 0 Latarcin precursor DUF919 PF06034.6 AMD20138.1 - 0.79 9.3 5.2 0.3 10.7 0.2 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF2404 PF10296.4 AMD20139.1 - 7.6e-05 22.7 0.2 0.00064 19.8 0.1 2.3 1 1 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) Polyketide_cyc PF03364.15 AMD20140.1 - 7.8e-16 58.2 0.0 1.1e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 AMD20140.1 - 0.072 13.2 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport SAP PF02037.22 AMD20141.1 - 4.8e-11 41.8 0.3 8.8e-11 41.0 0.2 1.5 1 0 0 1 1 1 1 SAP domain DUF2076 PF09849.4 AMD20142.1 - 1.9e-06 28.1 7.2 2.1e-06 28.0 5.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 AMD20142.1 - 8.7e-05 22.3 4.2 0.00013 21.7 2.9 1.3 1 0 0 1 1 1 1 CHCH domain DUF605 PF04652.11 AMD20142.1 - 0.17 11.2 4.2 0.19 11.0 2.9 1.1 1 0 0 1 1 1 0 Vta1 like Nucleoporin_FG PF13634.1 AMD20142.1 - 0.52 10.5 9.3 0.74 10.0 6.5 1.2 1 0 0 1 1 1 0 Nucleoporin FG repeat region TFIIA PF03153.8 AMD20142.1 - 4.4 7.0 5.8 5.6 6.7 4.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 AMD20142.1 - 9.5 4.3 8.6 11 4.0 6.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Cut8_N PF14482.1 AMD20143.1 - 0.017 15.1 0.4 0.017 15.1 0.3 2.1 2 0 0 2 2 2 0 Cut8 proteasome-binding domain Topoisom_I_N PF02919.10 AMD20144.1 - 1.5e-100 334.9 0.2 1.5e-100 334.9 0.1 3.1 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 AMD20144.1 - 1.5e-83 279.4 1.2 1.5e-83 279.4 0.8 2.5 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 AMD20144.1 - 1.6e-30 104.5 0.4 4.9e-30 103.0 0.3 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain Pkinase PF00069.20 AMD20145.1 - 5.9e-72 241.9 0.0 1.1e-71 241.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20145.1 - 3.7e-39 134.3 0.0 5.7e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.13 AMD20145.1 - 8.7e-35 118.5 1.1 3.6e-17 62.1 0.1 3.0 3 0 0 3 3 3 2 POLO box duplicated region Kinase-like PF14531.1 AMD20145.1 - 1e-10 41.0 0.0 3.5e-10 39.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 AMD20145.1 - 0.00063 18.8 0.0 0.0015 17.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_3 PF08239.6 AMD20145.1 - 0.0042 17.2 0.1 0.0079 16.3 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain GLTP PF08718.6 AMD20145.1 - 0.0062 16.5 0.1 0.081 12.9 0.0 2.4 1 1 0 2 2 2 1 Glycolipid transfer protein (GLTP) RNA_pol_L_2 PF13656.1 AMD20146.1 - 1.1e-26 92.0 0.1 1.4e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 AMD20146.1 - 2.7e-11 42.4 0.0 3.7e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Thymidylate_kin PF02223.12 AMD20146.1 - 0.027 13.8 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 Thymidylate kinase PAH PF02671.16 AMD20147.1 - 1.1e-48 162.5 6.2 1.8e-19 69.0 0.4 3.9 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 AMD20147.1 - 1.3e-43 146.8 0.5 4.4e-43 145.1 0.1 2.2 2 0 0 2 2 2 1 Sin3 family co-repressor zf-DHHC PF01529.15 AMD20148.1 - 7.3e-30 103.6 13.5 7.3e-30 103.6 9.4 2.2 1 1 1 2 2 2 1 DHHC palmitoyltransferase HlyIII PF03006.15 AMD20149.1 - 1.7e-49 168.2 22.1 2.1e-49 167.9 15.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DNA_pol_A_exo1 PF01612.15 AMD20150.1 - 5.8e-46 156.1 0.3 1e-45 155.3 0.2 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.7 AMD20150.1 - 7.1e-23 80.7 4.5 2.1e-22 79.2 0.7 2.9 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.18 AMD20150.1 - 3.7e-11 42.5 0.0 1.3e-10 40.8 0.0 2.0 2 0 0 2 2 2 1 HRDC domain Clusterin PF01093.12 AMD20150.1 - 0.0031 16.4 1.0 0.0046 15.8 0.1 1.7 2 0 0 2 2 2 1 Clusterin Baculo_PEP_C PF04513.7 AMD20150.1 - 0.36 10.6 13.9 1.9 8.2 5.0 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cyclin PF08613.6 AMD20151.1 - 2e-33 115.9 1.3 2e-33 115.9 0.9 1.9 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 AMD20151.1 - 0.00027 20.5 0.1 0.00059 19.3 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ras PF00071.17 AMD20152.1 - 1.5e-57 193.5 0.2 1.7e-57 193.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD20152.1 - 8.4e-20 71.4 0.0 1.4e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD20152.1 - 3.2e-15 55.8 0.0 3.6e-15 55.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 AMD20152.1 - 1.4e-08 34.1 0.1 1.7e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 AMD20152.1 - 1.6e-07 30.9 0.2 6.5e-06 25.7 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD20152.1 - 8.9e-06 25.6 0.0 1.4e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 AMD20152.1 - 5.1e-05 23.4 0.0 8.6e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 AMD20152.1 - 6e-05 22.3 0.0 8.4e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 AMD20152.1 - 0.0003 20.8 0.1 0.01 15.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain ATP_bind_1 PF03029.12 AMD20152.1 - 0.0011 18.5 0.4 0.036 13.5 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein NTPase_1 PF03266.10 AMD20152.1 - 0.0022 17.7 0.1 0.0072 16.0 0.0 1.8 2 0 0 2 2 2 1 NTPase AAA_24 PF13479.1 AMD20152.1 - 0.0033 17.0 0.1 0.0099 15.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 AMD20152.1 - 0.0037 16.9 0.2 0.0087 15.7 0.1 1.7 1 1 1 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 AMD20152.1 - 0.0053 16.2 0.1 0.014 14.8 0.0 1.7 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 AMD20152.1 - 0.0068 15.5 0.1 0.015 14.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Arch_ATPase PF01637.13 AMD20152.1 - 0.011 15.4 0.4 0.029 14.0 0.3 1.9 1 1 0 1 1 1 0 Archaeal ATPase NACHT PF05729.7 AMD20152.1 - 0.013 15.2 0.0 0.031 13.9 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.4 AMD20152.1 - 0.016 14.6 0.2 0.09 12.2 0.1 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.17 AMD20152.1 - 0.019 13.8 0.1 0.13 11.0 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain Septin PF00735.13 AMD20152.1 - 0.06 12.3 0.1 0.32 9.9 0.0 2.0 2 0 0 2 2 2 0 Septin AAA_10 PF12846.2 AMD20152.1 - 0.084 12.2 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_35 PF14516.1 AMD20152.1 - 0.12 10.9 0.0 0.28 9.7 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain Alg6_Alg8 PF03155.10 AMD20153.1 - 7.9e-151 503.0 33.1 9.5e-151 502.7 23.0 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family TPR_11 PF13414.1 AMD20154.1 - 1.1e-28 98.6 10.1 5.9e-19 67.4 2.3 3.5 2 1 1 4 4 4 2 TPR repeat TPR_1 PF00515.23 AMD20154.1 - 2e-20 71.4 9.9 5.8e-08 32.0 0.4 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20154.1 - 2.3e-18 64.5 9.9 5.6e-07 29.0 0.1 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 AMD20154.1 - 5.3e-13 49.2 4.7 4.4e-08 33.5 0.5 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 AMD20154.1 - 2.8e-10 39.5 2.4 7.2e-05 22.6 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 AMD20154.1 - 4.1e-08 33.1 0.0 0.16 12.7 0.0 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 AMD20154.1 - 4.5e-08 32.9 5.6 0.003 17.4 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 AMD20154.1 - 1.4e-07 31.7 3.0 0.00058 20.1 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20154.1 - 4.6e-06 26.0 10.6 0.0069 16.0 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 AMD20154.1 - 4.9e-05 23.3 2.6 0.00011 22.2 1.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 AMD20154.1 - 0.00014 21.6 0.0 0.094 12.5 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 AMD20154.1 - 0.00014 22.0 4.2 0.051 14.0 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.12 AMD20154.1 - 0.00041 20.6 0.3 0.0095 16.2 0.0 2.2 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_10 PF13374.1 AMD20154.1 - 0.00066 19.5 0.4 0.82 9.6 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD20154.1 - 0.0011 18.5 2.9 1.7 8.6 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 AMD20154.1 - 0.0037 17.1 4.1 0.16 11.8 0.1 3.5 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.1 AMD20154.1 - 0.014 15.4 2.9 0.36 10.9 0.0 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 AMD20154.1 - 0.16 11.8 0.2 0.16 11.8 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Prosystemin PF07376.6 AMD20154.1 - 0.4 10.0 10.0 0.15 11.4 0.5 2.2 2 0 0 2 2 2 0 Prosystemin MIT PF04212.13 AMD20154.1 - 1.7 8.5 16.4 13 5.7 2.9 4.4 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain VPS9 PF02204.13 AMD20155.1 - 3.3e-18 65.6 0.0 1.3e-17 63.7 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.1 AMD20155.1 - 1.5e-05 25.1 0.5 0.002 18.3 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD20155.1 - 0.0011 19.3 0.2 0.084 13.2 0.1 2.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 AMD20155.1 - 0.0083 15.8 0.0 0.087 12.6 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeat Antigen_Bd37 PF11641.3 AMD20155.1 - 0.0095 15.2 0.2 0.59 9.3 0.0 2.7 2 0 0 2 2 2 1 Glycosylphosphatidylinositol-anchored merozoite surface protein DUF2002 PF09400.5 AMD20155.1 - 0.046 13.4 0.2 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2002) Ank_4 PF13637.1 AMD20155.1 - 0.08 13.4 0.2 12 6.5 0.0 3.2 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank_3 PF13606.1 AMD20155.1 - 0.16 12.2 1.0 4.6 7.7 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeat DUF367 PF04034.8 AMD20156.1 - 2.4e-54 182.3 0.0 3.9e-54 181.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 AMD20156.1 - 1.8e-15 56.2 0.2 3.2e-15 55.4 0.2 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Jnk-SapK_ap_N PF09744.4 AMD20156.1 - 0.012 15.6 2.3 0.02 14.8 1.6 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DNA_ligase_A_M PF01068.16 AMD20157.1 - 6.6e-44 149.7 0.0 1.7e-43 148.3 0.0 1.7 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 AMD20157.1 - 3.1e-15 56.4 0.0 5.6e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 AMD20157.1 - 1.2e-05 25.6 0.0 3.2e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.21 AMD20157.1 - 0.0013 18.8 0.1 0.02 14.9 0.0 2.9 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.14 AMD20157.1 - 0.0091 15.7 0.3 1 8.9 0.0 3.0 2 1 0 2 2 2 1 mRNA capping enzyme, catalytic domain NPR2 PF06218.6 AMD20158.1 - 6.8e-168 558.8 8.4 9.5e-168 558.3 5.8 1.2 1 0 0 1 1 1 1 Nitrogen permease regulator 2 NPR3 PF03666.8 AMD20158.1 - 0.012 14.1 0.0 0.012 14.1 0.0 2.9 4 0 0 4 4 4 0 Nitrogen Permease regulator of amino acid transport activity 3 Kinesin PF00225.18 AMD20159.1 - 3e-96 322.0 6.2 3e-96 322.0 4.3 3.6 2 2 0 3 3 3 1 Kinesin motor domain ATG16 PF08614.6 AMD20159.1 - 0.0088 15.8 14.2 0.0088 15.8 9.8 3.0 4 0 0 4 4 4 1 Autophagy protein 16 (ATG16) Fcf1 PF04900.7 AMD20160.1 - 1.1e-32 112.1 2.3 2.7e-32 110.8 1.6 1.7 1 0 0 1 1 1 1 Fcf1 Fungal_trans_2 PF11951.3 AMD20161.1 - 3.3e-12 45.6 1.9 4.9e-12 45.1 1.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD20161.1 - 4.2e-08 32.9 13.3 8.3e-08 32.0 9.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF917 PF06032.7 AMD20162.1 - 7.8e-104 347.0 0.0 1.2e-103 346.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.13 AMD20162.1 - 2.2e-51 174.6 4.7 5.6e-50 170.0 0.7 2.3 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 AMD20162.1 - 1.6e-33 115.7 2.6 3.8e-32 111.2 0.0 3.1 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.1 AMD20162.1 - 0.0049 15.2 0.3 0.61 8.3 0.0 2.2 2 0 0 2 2 2 2 MutL protein RrnaAD PF00398.15 AMD20163.1 - 7e-63 212.1 0.0 8.2e-63 211.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 AMD20163.1 - 1.2e-10 41.4 0.0 3.4e-10 39.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD20163.1 - 5.3e-07 30.2 0.0 1.3e-06 28.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 AMD20163.1 - 6.8e-05 22.4 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 AMD20163.1 - 0.00068 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 AMD20163.1 - 0.0012 17.9 0.0 0.0054 15.8 0.0 1.8 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.1 AMD20163.1 - 0.0017 17.9 0.0 0.005 16.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD20163.1 - 0.0023 17.6 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD20163.1 - 0.0033 17.8 0.0 0.017 15.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.11 AMD20163.1 - 0.0066 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Ubie_methyltran PF01209.13 AMD20163.1 - 0.0067 15.5 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.13 AMD20163.1 - 0.0068 15.6 0.0 0.021 14.0 0.0 1.8 2 0 0 2 2 2 1 O-methyltransferase Methyltransf_25 PF13649.1 AMD20163.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PI-PLC-X PF00388.14 AMD20165.1 - 1.4e-47 160.7 0.0 3.2e-47 159.6 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 AMD20165.1 - 3.1e-36 123.9 0.3 7.3e-36 122.7 0.2 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.6 AMD20165.1 - 4e-06 26.7 2.8 1.8e-05 24.6 0.1 2.8 2 1 1 3 3 3 2 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.1 AMD20165.1 - 0.00056 20.0 7.3 0.0084 16.2 0.3 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 AMD20165.1 - 0.0019 17.3 0.3 0.013 14.7 0.0 2.6 2 0 0 2 2 2 1 EF hand C2 PF00168.25 AMD20165.1 - 0.0022 17.8 0.1 0.0069 16.2 0.0 1.9 2 0 0 2 2 2 1 C2 domain EF-hand_10 PF14788.1 AMD20165.1 - 0.012 15.3 0.7 0.012 15.3 0.5 2.6 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.1 AMD20165.1 - 0.029 13.9 0.1 12 5.6 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 AMD20165.1 - 0.16 11.9 0.8 2 8.5 0.1 2.8 2 0 0 2 2 2 0 EF-hand domain KAR9 PF08580.5 AMD20166.1 - 1e-86 291.7 21.9 2.2e-85 287.3 15.2 2.1 1 1 0 1 1 1 1 Yeast cortical protein KAR9 DUF1539 PF07560.6 AMD20166.1 - 0.00083 19.2 5.3 0.0026 17.6 1.0 3.1 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1539) Octopine_DH PF02317.12 AMD20166.1 - 0.051 13.2 0.0 0.22 11.1 0.0 2.1 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain ATP-synt_Eps PF04627.8 AMD20167.1 - 4e-18 64.6 1.4 4.9e-18 64.4 1.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain DNA_pol_phi PF04931.8 AMD20168.1 - 2.8e-101 339.6 54.8 6.1e-99 331.8 38.0 3.0 1 1 0 1 1 1 1 DNA polymerase phi Herpes_LMP1 PF05297.6 AMD20168.1 - 0.00041 19.3 2.7 0.00065 18.7 1.9 1.2 1 0 0 1 1 1 1 Herpesvirus latent membrane protein 1 (LMP1) Rad9 PF04139.8 AMD20169.1 - 0.37 9.8 6.8 0.66 9.0 3.1 2.0 2 0 0 2 2 2 0 Rad9 CAF1C_H4-bd PF12265.3 AMD20170.1 - 2.6e-24 84.8 0.6 5.4e-24 83.8 0.4 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 AMD20170.1 - 6.2e-24 82.9 0.8 2.9e-06 26.9 0.3 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Leptin PF02024.10 AMD20170.1 - 0.058 13.0 0.0 8.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Leptin Kelch_3 PF13415.1 AMD20171.1 - 9e-33 111.7 3.8 2.4e-10 40.2 0.0 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 AMD20171.1 - 1.3e-27 95.2 8.5 2.3e-05 24.0 0.1 7.0 5 2 1 6 6 6 5 Galactose oxidase, central domain DUF4110 PF13422.1 AMD20171.1 - 1e-26 92.5 0.3 1e-26 92.5 0.2 4.2 4 1 0 4 4 4 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.1 AMD20171.1 - 1.2e-22 79.1 9.8 3.8e-06 26.8 0.1 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.10 AMD20171.1 - 2.3e-15 55.6 12.2 0.0047 16.6 0.0 6.7 6 1 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 AMD20171.1 - 5.8e-13 48.1 11.4 0.00013 21.4 0.0 6.0 6 1 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 AMD20171.1 - 1e-10 41.3 10.2 0.0014 18.5 0.1 6.5 6 1 0 6 6 6 3 Kelch motif Nop14 PF04147.7 AMD20171.1 - 7.6 4.3 29.9 0.0058 14.6 8.7 2.1 2 0 0 2 2 2 0 Nop14-like family PGM_PMM_I PF02878.11 AMD20172.1 - 1.9e-16 59.7 0.0 8.2e-09 35.0 0.0 2.5 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 AMD20172.1 - 1.9e-10 40.9 0.0 1.1e-09 38.5 0.0 2.3 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 AMD20172.1 - 3.6e-10 39.7 0.1 9e-10 38.4 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Mitochondr_Som1 PF11093.3 AMD20173.1 - 3.8e-20 71.4 0.8 4.9e-20 71.1 0.6 1.2 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Lyase_1 PF00206.15 AMD20174.1 - 4.6e-115 384.0 0.0 5.9e-115 383.7 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 AMD20174.1 - 3.9e-26 90.8 0.0 9.7e-26 89.6 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus Peptidase_S8 PF00082.17 AMD20175.1 - 3.4e-51 174.0 5.3 5.4e-51 173.4 3.7 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 AMD20175.1 - 6.8e-11 42.5 0.1 1.5e-10 41.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 SUI1 PF01253.17 AMD20176.1 - 7.9e-29 99.3 0.4 9.5e-29 99.0 0.3 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.3 AMD20176.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Cas_Csa5 PF09702.5 AMD20176.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) Homeobox PF00046.24 AMD20177.1 - 1.7e-15 56.3 1.8 2e-15 56.1 1.3 1.1 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 AMD20177.1 - 1e-05 25.1 1.0 2.7e-05 23.7 0.2 2.0 2 0 0 2 2 2 1 Homeobox KN domain HA PF03457.9 AMD20178.1 - 0.062 13.4 0.2 0.082 13.0 0.1 1.2 1 0 0 1 1 1 0 Helicase associated domain CRC_subunit PF08624.5 AMD20180.1 - 5e-39 133.3 0.1 9.1e-39 132.5 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Lectin_leg-like PF03388.8 AMD20181.1 - 6e-37 126.9 0.1 9.3e-37 126.3 0.1 1.2 1 0 0 1 1 1 1 Legume-like lectin family Z1 PF10593.4 AMD20181.1 - 0.093 11.9 0.8 0.2 10.8 0.6 1.5 1 0 0 1 1 1 0 Z1 domain Synaptonemal_3 PF15191.1 AMD20181.1 - 0.16 11.7 0.8 1.1 8.9 0.2 2.4 3 0 0 3 3 3 0 Synaptonemal complex central element protein 3 Rdx PF10262.4 AMD20182.1 - 1.4e-24 85.8 0.0 1.8e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Rdx family FCH PF00611.18 AMD20183.1 - 7.4e-16 58.1 2.9 7.7e-15 54.8 0.0 3.0 2 1 1 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DEP PF00610.16 AMD20183.1 - 8.9e-13 47.7 0.2 2.1e-12 46.6 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.22 AMD20183.1 - 1.8e-08 34.1 0.4 1.8e-08 34.1 0.3 2.4 3 0 0 3 3 3 1 RhoGAP domain Lge1 PF11488.3 AMD20183.1 - 0.058 13.5 2.9 0.35 11.0 0.1 2.9 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 DUF1876 PF08962.6 AMD20183.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1876) EntA_Immun PF08951.5 AMD20183.1 - 0.17 12.0 4.8 8.6 6.5 0.1 3.6 3 0 0 3 3 3 0 Enterocin A Immunity Phage_tail_3 PF08813.6 AMD20184.1 - 0.093 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Phage tail protein V-SNARE_C PF12352.3 AMD20185.1 - 1.8e-06 27.9 4.4 1.8e-06 27.9 3.0 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 AMD20185.1 - 0.00066 19.3 0.5 0.00066 19.3 0.3 1.8 2 0 0 2 2 2 1 Sec20 Herpes_BBRF1 PF04793.7 AMD20185.1 - 0.0085 14.8 0.8 0.19 10.4 0.1 2.2 2 0 0 2 2 2 1 BRRF1-like protein Sec5 PF15469.1 AMD20185.1 - 0.039 13.6 1.0 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 Exocyst complex component Sec5 Erp_C PF06780.6 AMD20185.1 - 0.04 13.7 0.2 0.099 12.4 0.1 1.6 1 0 0 1 1 1 0 Erp protein C-terminus TPR_MLP1_2 PF07926.7 AMD20185.1 - 0.61 9.8 4.9 4.2 7.1 3.4 2.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FlgN PF05130.7 AMD20185.1 - 0.67 10.2 4.8 2.4 8.3 0.2 2.4 2 1 0 2 2 2 0 FlgN protein RCC1 PF00415.13 AMD20186.1 - 8.5e-23 80.3 6.0 1.6e-07 31.3 0.0 6.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 AMD20186.1 - 5.3e-20 70.4 10.1 4.1e-12 45.3 0.2 4.9 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat ETRAMP PF09716.5 AMD20186.1 - 0.24 11.4 1.6 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF1640 PF07798.6 AMD20187.1 - 3.6e-58 196.5 8.7 4.2e-58 196.2 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Fib_alpha PF08702.5 AMD20187.1 - 0.0083 16.2 2.9 0.0083 16.2 2.0 2.1 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family Prominin PF05478.6 AMD20187.1 - 0.0088 13.6 3.0 0.0093 13.5 2.1 1.1 1 0 0 1 1 1 1 Prominin YfbU PF03887.9 AMD20187.1 - 0.013 15.0 0.2 0.028 14.0 0.1 1.6 1 1 0 1 1 1 0 YfbU domain ERM PF00769.14 AMD20187.1 - 0.021 14.3 5.3 0.032 13.7 3.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family FlaC_arch PF05377.6 AMD20187.1 - 0.024 14.5 2.6 0.61 10.0 0.1 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ApoLp-III PF07464.6 AMD20187.1 - 0.025 14.6 8.4 0.034 14.1 3.6 2.2 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) P2_Phage_GpR PF06891.6 AMD20187.1 - 0.025 14.3 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 P2 phage tail completion protein R (GpR) DUF3138 PF11336.3 AMD20187.1 - 0.091 10.9 0.1 0.12 10.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Pox_A_type_inc PF04508.7 AMD20187.1 - 0.14 11.9 3.9 0.49 10.3 2.7 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DUF2756 PF10956.3 AMD20187.1 - 0.27 11.4 5.1 0.86 9.8 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2756) YlqD PF11068.3 AMD20187.1 - 0.51 10.3 14.9 0.84 9.6 2.7 2.2 1 1 1 2 2 2 0 YlqD protein COG2 PF06148.6 AMD20187.1 - 0.57 10.0 6.7 0.48 10.2 1.6 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.7 AMD20187.1 - 0.91 9.8 6.4 5.3 7.3 0.3 3.0 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.7 AMD20187.1 - 1 9.2 7.4 9.8 5.9 5.0 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Kinetocho_Slk19 PF12709.2 AMD20187.1 - 1.2 9.2 8.5 4.5 7.4 0.9 2.8 2 1 1 3 3 3 0 Central kinetochore-associated DUF4200 PF13863.1 AMD20187.1 - 1.7 8.6 11.7 4.4 7.2 8.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Atg14 PF10186.4 AMD20187.1 - 1.7 7.5 12.8 0.19 10.6 3.4 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Bacillus_HBL PF05791.6 AMD20187.1 - 2 7.7 9.9 10 5.4 6.0 2.4 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.7 AMD20187.1 - 2 8.2 7.4 7.4 6.3 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1451 PF07295.6 AMD20187.1 - 2.4 7.9 6.2 2.1 8.1 2.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) DUF4446 PF14584.1 AMD20187.1 - 3.7 7.3 8.3 0.76 9.6 1.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) PMM PF03332.8 AMD20188.1 - 2.2e-112 373.9 0.7 2.5e-112 373.8 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 AMD20188.1 - 3.5e-07 30.0 0.0 1.2e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 AMD20188.1 - 0.00077 18.8 0.0 0.4 9.9 0.0 2.0 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase RHH_1 PF01402.16 AMD20188.1 - 0.056 13.3 0.6 6.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family Ribosomal_L16 PF00252.13 AMD20189.1 - 1.7e-33 115.2 0.1 2.1e-33 114.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e zf-C2H2_jaz PF12171.3 AMD20190.1 - 8.1e-10 38.5 5.6 1.6e-09 37.5 2.5 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 AMD20190.1 - 0.001 19.1 0.5 0.0024 17.9 0.1 1.8 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 AMD20190.1 - 0.026 14.7 3.4 0.068 13.4 1.7 2.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF1767 PF08585.7 AMD20190.1 - 0.034 14.3 0.1 0.23 11.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1767) zf-U1 PF06220.7 AMD20190.1 - 0.076 12.5 1.6 0.16 11.5 1.1 1.5 1 0 0 1 1 1 0 U1 zinc finger TEX13 PF15186.1 AMD20190.1 - 0.088 12.3 0.4 0.13 11.8 0.2 1.3 1 1 0 1 1 1 0 Testis-expressed sequence 13 protein family RP-C PF03428.8 AMD20190.1 - 0.11 11.9 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain zf-C2H2_4 PF13894.1 AMD20190.1 - 0.36 11.2 2.2 0.49 10.8 0.5 2.0 3 0 0 3 3 3 0 C2H2-type zinc finger bZIP_2 PF07716.10 AMD20190.1 - 0.6 9.9 4.2 11 5.9 0.2 2.6 2 0 0 2 2 2 0 Basic region leucine zipper zf-H2C2_2 PF13465.1 AMD20190.1 - 0.87 9.9 3.4 1.7 9.0 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger double domain OTU PF02338.14 AMD20191.1 - 2e-12 47.7 0.0 3.5e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease BIR PF00653.16 AMD20191.1 - 0.072 13.5 0.0 0.23 11.8 0.0 1.8 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain USP8_dimer PF08969.6 AMD20192.1 - 2.1e-09 37.3 0.7 6.6e-09 35.7 0.5 1.8 1 1 0 1 1 1 1 USP8 dimerisation domain S_100 PF01023.14 AMD20192.1 - 0.011 14.9 0.0 0.027 13.7 0.0 1.6 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain GRAM PF02893.15 AMD20193.1 - 2.7e-18 65.2 0.1 6.1e-18 64.1 0.1 1.7 1 0 0 1 1 1 1 GRAM domain Med14 PF08638.6 AMD20194.1 - 4.2e-61 205.6 0.3 9.7e-61 204.4 0.2 1.7 1 0 0 1 1 1 1 Mediator complex subunit MED14 ADH_N PF08240.7 AMD20195.1 - 4.6e-29 100.3 1.0 1.8e-28 98.4 0.0 2.3 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 AMD20195.1 - 4.1e-27 94.2 0.1 7e-27 93.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 AMD20195.1 - 0.0055 17.5 0.0 0.011 16.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 AMD20195.1 - 0.065 12.7 0.4 0.065 12.7 0.3 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.14 AMD20195.1 - 0.13 11.3 0.1 0.25 10.4 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.22 AMD20195.1 - 0.18 12.2 1.1 3.2 8.2 0.4 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Cu-oxidase_2 PF07731.9 AMD20196.1 - 2.8e-42 143.4 5.3 3.5e-36 123.7 0.1 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 AMD20196.1 - 1e-38 132.7 6.4 6.3e-33 113.9 0.7 3.4 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.10 AMD20196.1 - 1.7e-38 130.9 7.3 5.3e-38 129.3 1.0 3.3 3 0 0 3 3 3 1 Multicopper oxidase GTP_EFTU PF00009.22 AMD20197.1 - 3.1e-60 202.8 0.6 1.2e-59 200.9 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 AMD20197.1 - 3.7e-32 110.3 0.1 7.4e-32 109.4 0.1 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 AMD20197.1 - 2.2e-31 107.5 0.0 5.2e-31 106.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 AMD20197.1 - 6.6e-23 80.3 0.0 3.6e-22 78.0 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 AMD20197.1 - 7.4e-12 45.2 0.1 2.1e-11 43.7 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AMD20197.1 - 0.007 16.3 0.0 0.021 14.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 AMD20197.1 - 0.049 14.1 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein rRNA_processing PF08524.6 AMD20198.1 - 1.2e-39 135.4 36.6 1.3e-39 135.3 25.4 1.0 1 0 0 1 1 1 1 rRNA processing DUF2072 PF09845.4 AMD20198.1 - 9.9 6.0 11.6 6.8 6.6 6.8 1.7 1 1 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) PPR_2 PF13041.1 AMD20199.1 - 3.5e-10 39.6 9.1 0.052 13.5 0.0 7.1 3 1 5 8 8 8 5 PPR repeat family PPR_3 PF13812.1 AMD20199.1 - 6.1e-08 32.3 5.2 6 7.4 0.0 8.4 9 0 0 9 9 9 2 Pentatricopeptide repeat domain PPR PF01535.15 AMD20199.1 - 2.6e-06 27.0 18.9 2.1 8.5 0.0 8.1 8 0 0 8 8 8 3 PPR repeat TPR_19 PF14559.1 AMD20199.1 - 0.024 14.9 0.3 1.1 9.6 0.0 3.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TP6A_N PF04406.9 AMD20199.1 - 0.027 14.1 0.1 0.15 11.7 0.0 2.2 2 0 0 2 2 2 0 Type IIB DNA topoisomerase SPC22 PF04573.7 AMD20200.1 - 8.2e-54 181.4 2.7 9.6e-54 181.2 1.9 1.0 1 0 0 1 1 1 1 Signal peptidase subunit DUF976 PF06162.7 AMD20200.1 - 0.036 13.5 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF976) Sugar_tr PF00083.19 AMD20201.1 - 3.3e-66 223.7 38.6 4.6e-66 223.2 26.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD20201.1 - 5.4e-17 61.5 42.0 1.2e-16 60.4 15.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MscL PF01741.13 AMD20201.1 - 0.24 11.5 2.4 1.1 9.4 1.7 2.1 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL DUF4006 PF13179.1 AMD20201.1 - 0.37 10.3 3.6 0.85 9.2 0.1 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF4006) Actin PF00022.14 AMD20202.1 - 3.2e-159 529.5 0.0 3.6e-159 529.4 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 AMD20202.1 - 0.05 14.0 0.1 0.21 11.9 0.0 1.9 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF788 PF05620.6 AMD20203.1 - 1.9e-34 119.0 3.8 2e-34 118.8 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) DUF3561 PF12084.3 AMD20203.1 - 0.23 11.3 6.0 0.25 11.2 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) DUF3366 PF11846.3 AMD20203.1 - 4.9 6.9 6.2 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3366) Ras PF00071.17 AMD20204.1 - 3.1e-63 211.9 0.5 3.7e-63 211.7 0.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD20204.1 - 1.9e-21 76.7 0.1 3.1e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD20204.1 - 3.1e-18 65.6 0.2 4e-18 65.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 AMD20204.1 - 3.7e-07 29.5 0.1 4.9e-07 29.1 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 AMD20204.1 - 2.2e-05 23.9 0.2 4.7e-05 22.8 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD20204.1 - 3.7e-05 23.6 0.1 5.2e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 AMD20204.1 - 0.00018 20.8 0.2 0.00022 20.5 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 AMD20204.1 - 0.0019 18.3 0.0 0.0035 17.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 AMD20204.1 - 0.006 16.7 0.0 0.14 12.3 0.0 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 AMD20204.1 - 0.016 14.4 0.0 0.033 13.3 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 AMD20204.1 - 0.018 15.0 0.1 0.064 13.2 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.13 AMD20204.1 - 0.023 14.0 0.2 0.15 11.3 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Septin PF00735.13 AMD20204.1 - 0.027 13.5 0.1 0.12 11.4 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_29 PF13555.1 AMD20204.1 - 0.03 13.8 0.2 0.1 12.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain CENP-M PF11111.3 AMD20204.1 - 0.068 12.3 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_5 PF07728.9 AMD20204.1 - 0.068 12.8 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 AMD20204.1 - 0.075 13.3 0.1 0.12 12.6 0.1 1.6 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.4 AMD20204.1 - 0.092 12.2 0.1 2.4 7.6 0.0 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Tubulin PF00091.20 AMD20206.1 - 1.7e-69 233.9 0.0 2.9e-69 233.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 AMD20206.1 - 3e-49 166.2 0.1 5.7e-49 165.3 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 AMD20206.1 - 0.0025 17.2 0.0 0.0045 16.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 AMD20206.1 - 0.0069 16.4 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain RNA_pol PF00940.14 AMD20207.1 - 7.7e-160 531.8 0.0 1.3e-159 531.0 0.0 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 AMD20207.1 - 9.9e-87 291.1 0.4 1.7e-86 290.4 0.2 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Mob1_phocein PF03637.12 AMD20208.1 - 5.1e-69 231.4 0.7 7e-69 230.9 0.5 1.2 1 0 0 1 1 1 1 Mob1/phocein family DUF3115 PF11312.3 AMD20209.1 - 2.8e-99 331.9 0.5 3.4e-99 331.7 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3115) Methyltransf_25 PF13649.1 AMD20209.1 - 0.013 15.8 0.0 0.034 14.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 AMD20209.1 - 0.032 13.9 0.0 0.052 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_L22e PF01776.12 AMD20210.1 - 8.9e-43 144.8 1.4 1.2e-42 144.3 1.0 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF726 PF05277.7 AMD20211.1 - 2.4e-129 431.1 1.0 4.4e-129 430.2 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF726) GCS PF03074.11 AMD20211.1 - 0.11 11.5 0.2 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 Glutamate-cysteine ligase Laps PF10169.4 AMD20211.1 - 0.24 11.6 13.2 0.058 13.6 4.8 2.6 2 0 0 2 2 2 0 Learning-associated protein G0-G1_switch_2 PF15103.1 AMD20211.1 - 0.56 10.4 2.9 12 6.2 0.0 3.2 3 0 0 3 3 3 0 G0/G1 switch protein 2 B3_4 PF03483.12 AMD20212.1 - 2.1e-30 105.4 0.0 3.4e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 AMD20212.1 - 1.4e-22 79.2 0.0 4.4e-18 64.8 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain tRNA-synt_2d PF01409.15 AMD20212.1 - 0.0085 15.3 0.0 0.094 11.8 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class II core domain (F) Herpes_V23 PF01802.12 AMD20212.1 - 0.016 14.2 0.2 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein Pkinase PF00069.20 AMD20213.1 - 1.1e-58 198.4 6.6 8.8e-38 129.9 0.2 3.0 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20213.1 - 2.5e-24 85.7 6.0 6.5e-21 74.5 0.1 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Response_reg PF00072.19 AMD20213.1 - 2.1e-06 27.7 0.0 6.7e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 Response regulator receiver domain Kdo PF06293.9 AMD20213.1 - 4.1e-05 22.7 0.0 0.0001 21.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 AMD20213.1 - 0.00013 21.0 5.4 0.00032 19.7 0.0 2.6 2 1 1 3 3 3 1 Kinase-like APH PF01636.18 AMD20213.1 - 0.00015 21.5 0.0 0.055 13.1 0.1 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family PAS_9 PF13426.1 AMD20213.1 - 0.008 16.5 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 AMD20213.1 - 0.017 14.9 0.0 0.017 14.9 0.0 2.4 2 0 0 2 2 2 0 PAS fold Seadorna_VP7 PF07387.6 AMD20213.1 - 0.019 13.8 0.1 0.034 12.9 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 PAS_4 PF08448.5 AMD20213.1 - 0.057 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 PAS fold RNase_T PF00929.19 AMD20214.1 - 5.4e-33 114.5 0.2 7e-33 114.2 0.1 1.1 1 0 0 1 1 1 1 Exonuclease PriCT_1 PF08708.6 AMD20214.1 - 0.033 13.9 0.0 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 Primase C terminal 1 (PriCT-1) bZIP_2 PF07716.10 AMD20215.1 - 3.9e-05 23.3 7.5 3.9e-05 23.3 5.2 1.7 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 AMD20215.1 - 0.00087 19.2 7.2 0.0016 18.3 5.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor DFF-C PF09033.5 AMD20215.1 - 0.073 12.9 1.3 0.15 11.9 0.9 1.4 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain SHMT PF00464.14 AMD20216.1 - 6e-207 686.7 0.0 7e-207 686.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.14 AMD20216.1 - 3.8e-07 29.2 0.0 5.6e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 AMD20216.1 - 7.6e-06 25.1 0.0 1.4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 AMD20216.1 - 0.00051 19.2 0.0 0.00087 18.5 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Glyco_hydro_47 PF01532.15 AMD20217.1 - 1.5e-84 284.2 0.2 1.9e-84 283.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Pkinase PF00069.20 AMD20219.1 - 3.2e-39 134.6 0.0 6.6e-39 133.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20219.1 - 2.3e-22 79.2 0.0 3.1e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AMD20219.1 - 8.3e-06 25.7 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 AMD20219.1 - 0.00014 20.9 0.1 0.00035 19.7 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 AMD20219.1 - 0.00023 20.8 0.1 0.011 15.3 0.1 2.2 1 1 1 2 2 2 1 Choline/ethanolamine kinase Laminin_N PF00055.12 AMD20219.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Laminin N-terminal (Domain VI) ABC_tran PF00005.22 AMD20220.1 - 1e-17 64.7 0.0 5.9e-17 62.2 0.0 2.0 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AMD20220.1 - 4.9e-11 43.1 2.1 1.5e-05 25.0 0.0 2.2 1 1 0 2 2 2 2 AAA domain AAA_15 PF13175.1 AMD20220.1 - 1.3e-06 27.7 0.0 0.008 15.2 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 AMD20220.1 - 2.5e-06 26.8 0.3 4.5e-05 22.7 0.2 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_10 PF12846.2 AMD20220.1 - 9.7e-06 25.2 0.0 4.2e-05 23.1 0.0 1.7 1 1 0 2 2 2 1 AAA-like domain DUF258 PF03193.11 AMD20220.1 - 0.00074 18.7 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 AMD20220.1 - 0.0015 18.0 0.0 0.0027 17.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Sigma54_activat PF00158.21 AMD20220.1 - 0.002 17.6 0.0 0.44 9.9 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_17 PF13207.1 AMD20220.1 - 0.008 16.9 0.8 0.019 15.8 0.5 1.7 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.1 AMD20220.1 - 0.0091 16.3 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 AMD20220.1 - 0.0092 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family Zeta_toxin PF06414.7 AMD20220.1 - 0.012 14.6 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.18 AMD20220.1 - 0.029 14.3 0.0 0.061 13.2 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.1 AMD20220.1 - 0.035 14.0 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 AMD20220.1 - 0.04 14.2 0.2 0.07 13.4 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 AMD20220.1 - 0.071 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 AMD20220.1 - 0.071 12.6 0.0 0.19 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.3 AMD20220.1 - 0.075 10.3 0.0 0.094 10.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MutS_V PF00488.16 AMD20220.1 - 0.075 12.4 0.0 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 MutS domain V Miro PF08477.8 AMD20220.1 - 0.082 13.4 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 AMD20220.1 - 0.088 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA_22 PF13401.1 AMD20220.1 - 0.12 12.5 2.0 0.85 9.7 1.4 2.1 1 1 0 1 1 1 0 AAA domain WD40 PF00400.27 AMD20221.1 - 3.9e-13 48.7 2.7 0.0029 17.4 0.0 7.3 8 0 0 8 8 8 3 WD domain, G-beta repeat SAPS PF04499.10 AMD20221.1 - 1.1 7.7 15.0 2.2 6.7 4.1 2.7 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein SPX PF03105.14 AMD20221.1 - 1.3 8.7 14.8 0.49 10.1 7.2 2.0 2 0 0 2 2 2 0 SPX domain Nop14 PF04147.7 AMD20221.1 - 7.8 4.2 55.4 0.063 11.1 28.2 2.0 2 0 0 2 2 2 0 Nop14-like family Cation_efflux PF01545.16 AMD20223.1 - 1.6e-81 273.5 6.6 2.1e-81 273.1 4.6 1.1 1 0 0 1 1 1 1 Cation efflux family COX6B PF02297.12 AMD20224.1 - 5.9e-23 80.6 6.2 8.1e-23 80.2 4.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Prolamin_like PF05617.6 AMD20224.1 - 0.36 10.9 2.9 0.93 9.6 1.9 1.8 1 1 1 2 2 2 0 Prolamin-like Pet191_N PF10203.4 AMD20224.1 - 0.72 9.9 3.9 2.7 8.0 2.5 1.9 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 RabGAP-TBC PF00566.13 AMD20225.1 - 1.5e-17 63.7 0.1 2.8e-17 62.9 0.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_L18ae PF01775.12 AMD20227.1 - 6.5e-57 190.7 0.7 8.8e-57 190.3 0.5 1.2 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain CTP_transf_1 PF01148.15 AMD20228.1 - 6.9e-21 75.0 9.9 4.8e-20 72.2 7.0 1.7 1 1 0 1 1 1 1 Cytidylyltransferase family Nop PF01798.13 AMD20229.1 - 4.9e-60 201.1 1.1 1.7e-59 199.4 0.8 2.0 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 AMD20229.1 - 1.5e-26 91.8 0.0 3e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 AMD20229.1 - 6.2e-20 71.1 2.8 6.2e-20 71.1 1.9 3.3 2 1 0 2 2 2 1 NOP5NT (NUC127) domain SART-1 PF03343.8 AMD20230.1 - 7.9e-56 189.6 56.0 7.9e-54 183.0 38.8 2.7 1 1 0 1 1 1 1 SART-1 family TPT PF03151.11 AMD20231.1 - 9.3e-24 83.8 9.9 9.3e-24 83.8 6.9 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 AMD20231.1 - 1.3e-05 25.2 28.7 0.00045 20.2 1.4 3.7 4 0 0 4 4 4 2 EamA-like transporter family UAA PF08449.6 AMD20231.1 - 8.1e-05 21.6 20.2 0.00037 19.5 14.0 2.1 1 1 0 1 1 1 1 UAA transporter family PIRT PF15099.1 AMD20231.1 - 1 8.5 4.0 0.75 9.0 0.2 2.4 2 1 1 3 3 3 0 Phosphoinositide-interacting protein family Mito_carr PF00153.22 AMD20232.1 - 8.5e-29 99.1 7.1 2.5e-12 46.3 0.0 3.3 2 1 0 3 3 3 3 Mitochondrial carrier protein DUF2034 PF10356.4 AMD20233.1 - 9.6e-51 171.5 0.0 1.1e-50 171.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 AMD20233.1 - 0.00034 20.4 0.0 0.012 15.3 0.0 2.1 2 0 0 2 2 2 1 Restriction endonuclease Med11 PF10280.4 AMD20234.1 - 0.014 15.3 1.4 0.017 15.1 1.0 1.3 1 1 0 1 1 1 0 Mediator complex protein FokI_N PF02981.10 AMD20234.1 - 0.052 13.1 0.5 0.056 13.0 0.3 1.1 1 0 0 1 1 1 0 Restriction endonuclease FokI, recognition domain TUG-UBL1 PF11470.3 AMD20234.1 - 0.052 13.4 0.1 0.069 13.0 0.1 1.2 1 0 0 1 1 1 0 GLUT4 regulating protein TUG YtzH PF14165.1 AMD20234.1 - 0.056 13.6 1.3 0.067 13.4 0.9 1.3 1 0 0 1 1 1 0 YtzH-like protein DUF3647 PF12363.3 AMD20234.1 - 0.081 13.0 1.0 0.089 12.8 0.7 1.1 1 0 0 1 1 1 0 Phage protein YusW PF14039.1 AMD20234.1 - 0.082 13.1 0.7 0.19 12.0 0.1 1.7 1 1 1 2 2 2 0 YusW-like protein DUF4618 PF15397.1 AMD20234.1 - 0.1 11.8 2.8 0.11 11.8 2.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Allexi_40kDa PF05549.6 AMD20234.1 - 0.46 9.7 2.4 0.48 9.6 1.7 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF382 PF04037.8 AMD20235.1 - 4.9e-50 168.6 0.0 9.8e-50 167.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.11 AMD20235.1 - 2.1e-17 62.2 1.1 3.9e-17 61.3 0.8 1.5 1 0 0 1 1 1 1 PSP Ribonuclease_3 PF00636.21 AMD20236.1 - 5.2e-17 62.3 0.0 1.3e-16 61.0 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 AMD20236.1 - 1.7e-13 50.6 0.0 3.2e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.20 AMD20236.1 - 0.0018 18.8 0.0 0.0039 17.7 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif SNF2_N PF00176.18 AMD20237.1 - 1.4e-81 273.6 0.3 2.3e-81 272.8 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 AMD20237.1 - 2.6e-42 143.2 2.2 2.6e-42 143.2 1.5 2.9 4 0 0 4 4 4 1 SLIDE HAND PF09110.6 AMD20237.1 - 7.5e-35 119.7 0.7 7.5e-35 119.7 0.5 2.4 2 0 0 2 2 2 1 HAND Helicase_C PF00271.26 AMD20237.1 - 2.8e-15 55.9 0.0 7.7e-15 54.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD20237.1 - 6.9e-10 39.0 0.0 5.8e-09 36.0 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 AMD20237.1 - 7.2e-06 25.5 0.3 3.8e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.26 AMD20237.1 - 5.3e-05 23.1 0.0 0.002 18.1 0.0 3.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain DEAD_2 PF06733.10 AMD20237.1 - 0.0011 18.3 0.8 0.0035 16.7 0.0 2.2 2 0 0 2 2 2 1 DEAD_2 AAA_14 PF13173.1 AMD20237.1 - 0.02 14.8 0.5 0.1 12.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 AMD20237.1 - 5.8 6.4 8.3 2.6 7.5 0.2 3.5 4 1 0 4 4 4 0 AAA domain RCC1 PF00415.13 AMD20238.1 - 1.1e-11 44.7 2.7 1.8e-06 28.0 0.0 4.1 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 AMD20238.1 - 8e-07 28.5 11.9 1.9e-05 24.1 1.5 3.4 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 AMD20238.1 - 0.0046 16.9 0.0 0.014 15.3 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain Ank_4 PF13637.1 AMD20238.1 - 0.057 13.9 0.3 0.47 11.0 0.0 2.6 3 0 0 3 3 3 0 Ankyrin repeats (many copies) VirC2 PF07181.6 AMD20239.1 - 0.15 11.4 0.1 1.3 8.3 0.0 2.4 3 0 0 3 3 3 0 VirC2 protein RGS PF00615.14 AMD20240.1 - 0.004 17.2 1.1 0.049 13.7 0.0 2.6 1 1 1 2 2 2 1 Regulator of G protein signaling domain Glyco_hydro_76 PF03663.9 AMD20241.1 - 7.5e-134 446.7 4.0 9.4e-134 446.4 2.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 AMD20241.1 - 0.059 12.3 3.0 7.6 5.4 1.0 3.0 1 1 1 2 2 2 0 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.9 AMD20242.1 - 1.6e-133 445.6 4.0 2e-133 445.3 2.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.8 AMD20242.1 - 0.0019 17.3 2.2 7.3 5.5 0.0 3.1 2 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 Glyco_hydro_47 PF01532.15 AMD20242.1 - 0.036 12.7 0.4 0.46 9.0 0.0 2.0 1 1 0 2 2 2 0 Glycosyl hydrolase family 47 ChAPs PF09295.5 AMD20243.1 - 3.6e-163 542.9 0.5 5e-163 542.4 0.3 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_16 PF13432.1 AMD20243.1 - 0.013 16.1 0.2 0.11 13.1 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 AMD20243.1 - 0.051 13.2 0.1 3.6 7.3 0.0 2.7 2 0 0 2 2 2 0 TPR repeat TPR_14 PF13428.1 AMD20243.1 - 0.2 12.4 0.7 30 5.6 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20243.1 - 0.67 10.0 2.5 4.5 7.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TFIID-31kDa PF02291.10 AMD20244.1 - 1.3e-53 180.2 0.0 1.5e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit MBF1 PF08523.5 AMD20245.1 - 2.4e-24 85.1 0.3 5e-24 84.1 0.2 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 AMD20245.1 - 6.8e-15 54.6 0.2 1.3e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.2 AMD20245.1 - 9.1e-07 28.8 0.1 1.4e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 AMD20245.1 - 2.4e-06 27.6 0.0 5.6e-06 26.4 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_25 PF13413.1 AMD20245.1 - 0.12 11.9 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain LRR_1 PF00560.28 AMD20246.1 - 6.5e-10 37.6 2.1 7.5 7.0 0.0 8.2 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.1 AMD20246.1 - 9.5e-09 34.4 12.7 0.97 9.7 0.0 8.6 10 0 0 10 10 10 2 Leucine Rich repeat LRR_4 PF12799.2 AMD20246.1 - 1.7e-07 30.6 19.0 0.024 14.2 0.7 6.5 5 2 3 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 AMD20246.1 - 0.00013 21.6 14.1 1 9.1 0.3 6.0 4 1 1 5 5 5 3 Leucine rich repeat LRR_7 PF13504.1 AMD20246.1 - 0.00054 19.7 9.0 14 6.4 0.0 7.2 8 0 0 8 8 8 1 Leucine rich repeat Bombinin PF05298.6 AMD20246.1 - 0.06 12.8 0.7 0.13 11.7 0.5 1.5 1 0 0 1 1 1 0 Bombinin Acyltransferase PF01553.16 AMD20247.1 - 3.3e-05 23.3 0.0 9.9e-05 21.7 0.0 1.8 1 0 0 1 1 1 1 Acyltransferase CybS PF05328.7 AMD20248.1 - 4.3e-50 168.7 0.0 5e-50 168.5 0.0 1.0 1 0 0 1 1 1 1 CybS Sdh_cyt PF01127.17 AMD20248.1 - 0.0084 15.9 2.5 0.07 12.9 1.7 2.0 1 1 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit STE2 PF02116.10 AMD20249.1 - 3.7e-91 305.0 18.3 4.5e-91 304.8 12.7 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR DUF4267 PF14087.1 AMD20249.1 - 0.044 13.3 0.5 0.044 13.3 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4267) Romo1 PF10247.4 AMD20249.1 - 0.056 13.6 0.7 0.15 12.2 0.5 1.7 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 DUF4649 PF15507.1 AMD20249.1 - 0.088 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4649) PGAP1 PF07819.8 AMD20250.1 - 3.8e-90 301.3 0.0 6.1e-90 300.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 AMD20250.1 - 0.0031 17.4 0.0 0.0073 16.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD20250.1 - 0.0036 16.8 0.0 0.0069 15.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AMD20250.1 - 0.0087 15.8 0.0 0.024 14.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 AMD20250.1 - 0.041 13.1 0.0 0.085 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Lipase_3 PF01764.20 AMD20250.1 - 0.048 13.2 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.15 AMD20250.1 - 0.048 13.0 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase LCAT PF02450.10 AMD20250.1 - 0.053 12.4 0.1 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase EPL1 PF10513.4 AMD20251.1 - 5.8e-33 114.3 2.0 5.8e-33 114.3 1.4 3.2 3 0 0 3 3 3 1 Enhancer of polycomb-like Suf PF05843.9 AMD20251.1 - 0.3 10.7 23.2 0.45 10.1 8.1 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF3835 PF12927.2 AMD20252.1 - 7.8e-20 71.6 1.1 1.5e-17 64.2 0.1 6.7 6 2 1 7 7 7 2 Domain of unknown function (DUF3835) Prefoldin PF02996.12 AMD20252.1 - 5.5e-10 38.9 1.4 5.5e-10 38.9 0.9 2.9 3 0 0 3 3 3 1 Prefoldin subunit GCR1_C PF12550.3 AMD20253.1 - 1.3e-12 47.3 7.2 1.4e-11 44.1 1.4 2.7 3 0 0 3 3 3 2 Transcriptional activator of glycolytic enzymes EBP PF05241.7 AMD20253.1 - 0.046 12.7 0.0 0.067 12.2 0.0 1.2 1 0 0 1 1 1 0 Emopamil binding protein Nop14 PF04147.7 AMD20254.1 - 0.00038 18.5 38.6 0.00038 18.5 26.8 2.4 3 0 0 3 3 3 1 Nop14-like family tRNA-synt_2d PF01409.15 AMD20255.1 - 7.2e-91 303.7 0.0 1e-90 303.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 AMD20255.1 - 8.2e-07 28.7 0.2 3.1e-06 26.8 0.1 2.0 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 AMD20255.1 - 9.2e-06 24.6 3.7 0.00014 20.8 0.1 3.2 2 2 1 3 3 3 1 tRNA synthetases class II (D, K and N) PaaX PF07848.7 AMD20255.1 - 0.03 14.3 0.0 3.4 7.7 0.0 2.9 3 0 0 3 3 3 0 PaaX-like protein tRNA-synt_His PF13393.1 AMD20255.1 - 0.076 12.0 0.0 0.17 10.8 0.0 1.5 1 0 0 1 1 1 0 Histidyl-tRNA synthetase UDPG_MGDP_dh_N PF03721.9 AMD20255.1 - 0.079 12.3 0.1 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrmB PF01978.14 AMD20255.1 - 0.11 12.2 0.1 0.7 9.6 0.0 2.4 2 1 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF2084 PF09857.4 AMD20255.1 - 0.12 12.1 0.6 7.3 6.3 0.0 2.8 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2084) Fcf2 PF08698.6 AMD20257.1 - 3e-33 113.7 0.2 5.4e-33 112.9 0.2 1.4 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing GATA PF00320.22 AMD20258.1 - 7.7e-15 53.9 6.0 1.6e-14 52.9 4.2 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.5 AMD20258.1 - 1.2e-09 37.5 1.0 1.9e-09 36.9 0.1 1.8 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) Mito_fiss_reg PF05308.6 AMD20258.1 - 0.0011 18.4 6.3 0.0018 17.6 4.4 1.3 1 0 0 1 1 1 1 Mitochondrial fission regulator CAP_N PF01213.14 AMD20258.1 - 0.032 13.5 7.1 0.049 12.9 5.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TMEM171 PF15471.1 AMD20258.1 - 0.18 10.5 2.6 0.28 9.9 1.8 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Pyr_redox_dim PF02852.17 AMD20259.1 - 5.4e-43 145.5 0.1 1.6e-42 143.9 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 AMD20259.1 - 3.5e-40 138.0 10.4 1.6e-38 132.6 7.2 3.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 AMD20259.1 - 8.1e-22 77.4 9.9 4.8e-19 68.5 0.6 3.8 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 AMD20259.1 - 6.4e-12 45.0 4.7 1.1e-10 41.0 0.8 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.2 AMD20259.1 - 2.5e-11 43.3 4.9 1e-10 41.2 0.2 2.8 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AMD20259.1 - 5.6e-11 42.3 1.8 4.4e-05 23.4 0.2 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 AMD20259.1 - 2.7e-09 37.4 0.5 2.3e-06 27.8 0.1 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 AMD20259.1 - 1.2e-08 34.2 12.5 0.0017 17.3 0.2 4.2 3 1 1 4 4 4 3 FAD dependent oxidoreductase HI0933_like PF03486.9 AMD20259.1 - 3.3e-08 32.4 7.9 6.7e-05 21.5 0.1 4.1 3 1 1 4 4 4 2 HI0933-like protein FAD_binding_2 PF00890.19 AMD20259.1 - 1.8e-07 30.4 1.9 1.8e-07 30.4 1.3 2.5 2 1 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.14 AMD20259.1 - 1.7e-06 27.3 10.3 0.012 14.7 0.6 3.8 2 1 0 2 2 2 2 FAD binding domain Thi4 PF01946.12 AMD20259.1 - 1.8e-06 27.2 3.0 0.00049 19.2 0.0 2.6 3 0 0 3 3 3 2 Thi4 family K_oxygenase PF13434.1 AMD20259.1 - 6.1e-05 22.0 0.7 0.65 8.8 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.16 AMD20259.1 - 0.00011 21.8 2.3 0.02 14.4 0.0 2.7 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.7 AMD20259.1 - 0.0049 15.8 2.3 0.12 11.2 0.2 2.4 2 1 0 2 2 2 1 Lycopene cyclase protein THF_DHG_CYH_C PF02882.14 AMD20259.1 - 0.01 14.8 0.1 0.045 12.8 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.13 AMD20259.1 - 0.049 13.2 0.3 0.049 13.2 0.2 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 AMD20259.1 - 0.12 12.6 2.7 1.7 8.9 0.2 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.9 AMD20259.1 - 0.23 10.0 4.7 0.81 8.2 0.3 2.3 2 0 0 2 2 2 0 Tryptophan halogenase LSM PF01423.17 AMD20260.1 - 2.6e-16 58.9 0.0 2.9e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 LSM domain Acetyltransf_1 PF00583.19 AMD20261.1 - 2.3e-13 49.9 0.0 3.7e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AMD20261.1 - 2.2e-08 34.1 0.0 3.1e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AMD20261.1 - 0.044 13.6 0.0 0.053 13.3 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Rhv PF00073.15 AMD20262.1 - 0.05 13.2 0.2 9 5.9 0.1 2.3 2 0 0 2 2 2 0 picornavirus capsid protein Selenoprotein_S PF06936.6 AMD20262.1 - 0.17 11.3 3.4 0.32 10.5 2.3 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) DUF2781 PF10914.3 AMD20263.1 - 2.1e-31 108.7 11.2 2.6e-31 108.4 7.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DnaJ PF00226.26 AMD20264.1 - 8.9e-26 89.4 2.7 1.6e-25 88.5 1.9 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 AMD20264.1 - 5.6e-20 71.0 1.2 2.6e-13 49.6 0.0 3.0 4 0 0 4 4 4 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 AMD20264.1 - 1.9e-11 43.8 21.8 2.9e-11 43.2 15.1 1.3 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 AMD20264.1 - 0.091 12.4 10.0 0.044 13.4 1.2 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Apolipoprotein PF01442.13 AMD20265.1 - 8.2e-09 35.2 12.5 3.9e-08 33.0 8.7 1.9 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF883 PF05957.8 AMD20265.1 - 3.5e-07 30.5 31.6 0.0024 18.2 3.5 4.1 1 1 3 4 4 4 4 Bacterial protein of unknown function (DUF883) YtxH PF12732.2 AMD20265.1 - 0.00048 20.4 31.7 2.2e+02 2.2 9.4 4.5 1 1 1 2 2 2 0 YtxH-like protein Tape_meas_lam_C PF09718.5 AMD20265.1 - 0.00093 19.0 17.7 1.4 8.8 0.8 4.7 2 1 3 5 5 5 4 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF4456 PF14644.1 AMD20265.1 - 0.0011 18.2 4.7 0.011 15.0 0.2 2.9 1 1 2 3 3 3 1 Domain of unknown function (DUF4456) Prominin PF05478.6 AMD20265.1 - 0.02 12.4 5.3 0.011 13.3 0.8 1.9 1 1 1 2 2 2 0 Prominin Synuclein PF01387.12 AMD20265.1 - 0.024 14.5 21.7 0.013 15.4 8.9 2.5 1 1 1 2 2 2 0 Synuclein Perilipin PF03036.11 AMD20265.1 - 0.059 12.1 8.5 0.13 11.0 5.9 1.5 1 1 0 1 1 1 0 Perilipin family EspB PF05802.6 AMD20265.1 - 0.15 10.9 29.3 0.66 8.8 10.3 2.1 1 1 1 2 2 2 0 Enterobacterial EspB protein ApoA-II PF04711.8 AMD20265.1 - 0.17 11.7 0.3 0.17 11.7 0.2 2.2 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) Phasin PF05597.6 AMD20265.1 - 0.2 11.3 23.5 0.43 10.3 4.1 3.8 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) SPX PF03105.14 AMD20265.1 - 1.1 8.9 18.7 1.4 8.6 12.9 1.0 1 0 0 1 1 1 0 SPX domain Sec5 PF15469.1 AMD20265.1 - 1.3 8.6 6.0 4.4 6.9 0.2 2.5 1 1 1 2 2 2 0 Exocyst complex component Sec5 SNARE PF05739.14 AMD20265.1 - 1.6 8.5 10.6 15 5.3 0.1 4.6 3 1 3 6 6 6 0 SNARE domain Rapamycin_bind PF08771.6 AMD20265.1 - 2.8 8.0 6.6 3 7.9 0.7 2.9 1 1 1 3 3 3 0 Rapamycin binding domain Plasmid_stabil PF05016.9 AMD20265.1 - 3.6 8.0 8.9 28 5.1 0.3 3.5 1 1 3 4 4 4 0 Plasmid stabilisation system protein HABP4_PAI-RBP1 PF04774.10 AMD20266.1 - 3.9e-05 24.0 0.1 4.7e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family Gly_transf_sug PF04488.10 AMD20267.1 - 2e-19 69.8 0.0 3.7e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF3481 PF11980.3 AMD20267.1 - 0.012 15.3 3.4 0.27 11.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3481) TMEM190 PF15431.1 AMD20267.1 - 0.04 13.8 1.5 0.24 11.3 0.0 2.4 3 0 0 3 3 3 0 Transmembrane protein 190 TcdA_TcdB PF12919.2 AMD20267.1 - 0.11 10.8 2.9 2.7 6.3 0.1 2.2 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain CTP_transf_2 PF01467.21 AMD20268.1 - 5.3e-18 65.5 0.0 1.2e-13 51.3 0.0 2.4 2 1 0 2 2 2 2 Cytidylyltransferase Prp18 PF02840.10 AMD20269.1 - 2.8e-36 124.4 0.1 1e-35 122.6 0.1 1.7 1 1 0 1 1 1 1 Prp18 domain TFIIF_beta PF02270.10 AMD20270.1 - 6.7e-94 314.7 13.1 9.8e-94 314.1 9.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit Ribosomal_L38e PF01781.13 AMD20271.1 - 3.4e-26 90.7 0.9 3.8e-26 90.6 0.6 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Pex24p PF06398.6 AMD20272.1 - 1.3e-94 316.9 6.9 1.8e-94 316.4 4.8 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin zf-CCCH PF00642.19 AMD20273.1 - 1.5e-09 37.3 3.0 1.5e-09 37.3 2.0 1.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.1 AMD20273.1 - 1.1e-06 28.2 8.4 1.8e-06 27.5 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD20273.1 - 1.8e-06 27.6 9.8 4.9e-06 26.2 6.8 1.7 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 AMD20273.1 - 2.7e-06 27.2 12.3 4.9e-06 26.4 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD20273.1 - 6.6e-06 25.7 12.2 1.2e-05 24.9 8.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 AMD20273.1 - 4e-05 23.1 12.7 7.3e-05 22.3 8.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 AMD20273.1 - 0.0075 16.1 9.5 0.017 15.0 6.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 AMD20273.1 - 0.03 14.0 3.3 0.063 13.0 2.3 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 AMD20273.1 - 0.079 12.6 7.5 0.23 11.2 5.2 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-P11 PF03854.9 AMD20273.1 - 0.49 9.9 5.0 0.95 8.9 3.5 1.5 1 0 0 1 1 1 0 P-11 zinc finger zf-Nse PF11789.3 AMD20273.1 - 1 8.9 6.5 2.2 7.8 4.5 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-Sec23_Sec24 PF04810.10 AMD20273.1 - 6.6 6.3 9.9 1.1e+02 2.4 6.9 2.2 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger Cullin PF00888.17 AMD20274.1 - 7.6e-99 331.8 17.3 7.6e-99 331.8 12.0 1.7 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 AMD20274.1 - 3.2e-17 62.0 1.6 9.9e-17 60.5 1.1 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain Sulphotransf PF09037.5 AMD20274.1 - 0.051 13.0 0.1 3.3 7.1 0.0 2.4 2 0 0 2 2 2 0 Stf0 sulphotransferase PCI PF01399.22 AMD20274.1 - 0.066 13.5 2.2 0.67 10.2 0.0 3.5 4 0 0 4 4 4 0 PCI domain TusA PF01206.12 AMD20275.1 - 0.026 14.1 0.1 0.4 10.3 0.0 2.5 2 0 0 2 2 2 0 Sulfurtransferase TusA Myb_DNA-bind_6 PF13921.1 AMD20275.1 - 2.8 8.1 8.5 0.26 11.4 0.7 3.0 3 1 0 3 3 3 0 Myb-like DNA-binding domain Ubie_methyltran PF01209.13 AMD20276.1 - 4.7e-95 317.1 0.0 5.5e-95 316.9 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 AMD20276.1 - 9e-13 48.0 0.0 1.5e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD20276.1 - 6.9e-10 39.2 0.0 1.2e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD20276.1 - 1.5e-09 38.2 0.0 2.9e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD20276.1 - 1.8e-07 31.4 0.0 4.2e-07 30.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD20276.1 - 7e-07 29.1 0.0 1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD20276.1 - 7.2e-06 26.5 0.0 1.3e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AMD20276.1 - 0.0007 19.6 0.0 0.005 16.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.12 AMD20276.1 - 0.021 14.2 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.1 AMD20276.1 - 0.022 14.4 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 AMD20276.1 - 0.098 13.4 0.0 0.21 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.10 AMD20276.1 - 0.12 11.9 0.0 0.43 10.1 0.0 1.9 1 1 1 2 2 2 0 Hypothetical methyltransferase ADH_zinc_N PF00107.21 AMD20276.1 - 0.15 11.5 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Bul1_N PF04425.7 AMD20277.1 - 1.8e-151 504.6 0.1 1.8e-151 504.6 0.0 1.7 2 0 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.7 AMD20277.1 - 6.1e-97 324.0 9.5 6.1e-97 324.0 6.6 2.2 2 0 0 2 2 2 1 Bul1 C terminus DUF2278 PF10042.4 AMD20277.1 - 0.0018 18.0 0.3 0.0042 16.8 0.2 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2278) CTK3_C PF12350.3 AMD20278.1 - 1.1e-19 70.2 5.6 2e-19 69.3 3.9 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.3 AMD20278.1 - 3.8e-08 33.0 0.1 1.8e-07 30.9 0.1 2.0 1 1 0 1 1 1 1 CTD kinase subunit gamma CTK3 ubiquitin PF00240.18 AMD20280.1 - 3.7e-21 74.3 0.1 5.5e-21 73.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 AMD20280.1 - 1e-13 50.7 0.0 1.5e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.26 AMD20280.1 - 2e-07 30.6 0.0 6.8e-07 28.9 0.0 2.0 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_2 PF14560.1 AMD20280.1 - 7.9e-07 29.2 0.0 1.6e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 AMD20280.1 - 1.6e-05 24.7 0.1 3.9e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 AMD20280.1 - 6.2e-05 23.1 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain UN_NPL4 PF11543.3 AMD20280.1 - 0.027 14.7 0.1 0.043 14.1 0.1 1.3 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 L27_2 PF09045.5 AMD20280.1 - 0.03 13.8 0.1 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 L27_2 TAF8_C PF10406.4 AMD20281.1 - 1.4e-20 73.0 0.3 1.4e-20 73.0 0.2 3.0 3 0 0 3 3 3 1 Transcription factor TFIID complex subunit 8 C-term SPR1 PF15356.1 AMD20281.1 - 0.35 11.2 11.6 0.72 10.2 8.0 1.5 1 0 0 1 1 1 0 Psoriasis susceptibility locus 2 NIF PF03031.13 AMD20282.1 - 7.5e-23 80.9 0.0 2.2e-22 79.4 0.0 1.9 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.21 AMD20282.1 - 2.9e-12 46.5 0.1 9.9e-12 44.8 0.1 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 AMD20282.1 - 3e-08 33.3 0.0 6.9e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain Biotin_lipoyl_2 PF13533.1 AMD20282.1 - 1e-06 28.2 0.0 0.025 14.2 0.0 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like DUF1664 PF07889.7 AMD20282.1 - 0.14 12.0 6.8 0.39 10.5 4.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PGM_PMM_I PF02878.11 AMD20283.1 - 7.5e-37 125.8 0.0 1.5e-36 124.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 AMD20283.1 - 1.2e-20 73.7 0.0 2.9e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 AMD20283.1 - 5.2e-13 49.0 0.0 8.6e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 AMD20283.1 - 1.1e-08 34.9 0.0 2.8e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Anp1 PF03452.9 AMD20284.1 - 3.6e-120 400.1 0.0 4.8e-120 399.7 0.0 1.1 1 0 0 1 1 1 1 Anp1 Asp PF00026.18 AMD20285.1 - 1.3e-41 142.8 0.3 1.6e-41 142.5 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 AMD20285.1 - 3.5e-09 36.3 0.0 3.8e-06 26.5 0.0 2.4 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal TAXi_N PF14543.1 AMD20285.1 - 4.6e-07 29.9 0.0 2.8e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Nab6_mRNP_bdg PF10567.4 AMD20286.1 - 2.9e-87 292.5 10.6 2.9e-87 292.5 7.4 2.2 2 0 0 2 2 2 1 RNA-recognition motif RRM PF10378.4 AMD20286.1 - 3.5e-19 68.1 9.3 3.5e-19 68.1 6.4 3.0 3 0 0 3 3 3 1 Putative RRM domain RRM_6 PF14259.1 AMD20286.1 - 1.4e-07 31.3 0.0 0.00028 20.8 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20286.1 - 1.2e-05 25.0 0.1 0.0029 17.4 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD20286.1 - 0.0019 17.7 0.0 0.33 10.5 0.0 2.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.13 AMD20287.1 - 1.6e-37 128.7 0.7 3.7e-37 127.5 0.5 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD20287.1 - 1.6e-10 40.7 13.0 2.7e-10 39.9 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PIG-L PF02585.12 AMD20288.1 - 4.2e-22 79.0 0.0 6.2e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.2 AMD20289.1 - 2.5e-26 91.5 0.6 1.1e-24 86.2 0.2 2.4 1 1 1 2 2 2 2 Mitochondrial ATPase expression NLE PF08154.7 AMD20289.1 - 0.24 11.4 1.2 0.69 9.9 0.1 2.1 2 0 0 2 2 2 0 NLE (NUC135) domain Exo_endo_phos PF03372.18 AMD20290.1 - 4.3e-19 69.4 0.1 5.9e-19 68.9 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ku PF02735.11 AMD20291.1 - 1.5e-19 70.1 0.0 2.9e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 AMD20291.1 - 2.3e-09 36.9 0.3 8.7e-09 35.1 0.1 2.1 2 1 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.9 AMD20291.1 - 0.0059 17.1 0.2 0.014 15.8 0.1 1.8 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm Init_tRNA_PT PF04179.7 AMD20292.1 - 5.2e-140 467.2 0.0 5.9e-140 467.1 0.0 1.0 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase Ribosomal_L30 PF00327.15 AMD20293.1 - 5.8e-13 48.2 0.1 7.9e-13 47.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e RNB PF00773.14 AMD20295.1 - 4.8e-67 226.5 0.3 8.3e-67 225.7 0.2 1.3 1 0 0 1 1 1 1 RNB domain Pyr_redox_2 PF07992.9 AMD20296.1 - 3.6e-28 98.8 1.5 4.3e-19 69.2 0.0 3.5 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 AMD20296.1 - 1.2e-13 51.2 0.1 2.3e-10 40.7 0.1 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 AMD20296.1 - 4.6e-10 39.9 0.0 5.9e-06 26.4 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Glyco_trans_4_3 PF12000.3 AMD20296.1 - 0.053 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Gkycosyl transferase family 4 group K_oxygenase PF13434.1 AMD20296.1 - 0.13 11.1 0.2 29 3.4 0.0 3.2 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) Gtr1_RagA PF04670.7 AMD20297.1 - 1.2e-93 312.5 1.5 1.2e-93 312.5 0.3 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ras PF00071.17 AMD20297.1 - 5.5e-08 32.3 0.1 9.6e-08 31.5 0.0 1.4 1 0 0 1 1 1 1 Ras family Arf PF00025.16 AMD20297.1 - 1e-07 31.3 0.5 3.1e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family Miro PF08477.8 AMD20297.1 - 5.9e-07 30.0 0.0 1.5e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 AMD20297.1 - 6.3e-06 26.1 0.0 1.1e-05 25.3 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 AMD20297.1 - 0.0062 16.8 0.1 0.013 15.7 0.1 1.8 1 1 0 1 1 1 1 ABC transporter SopD PF11047.3 AMD20297.1 - 0.014 14.3 0.7 0.025 13.5 0.5 1.4 1 0 0 1 1 1 0 Salmonella outer protein D AIG1 PF04548.11 AMD20297.1 - 0.026 13.6 0.7 0.29 10.2 0.1 2.2 1 1 1 2 2 2 0 AIG1 family DUF815 PF05673.8 AMD20297.1 - 0.031 13.2 0.0 0.061 12.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.1 AMD20297.1 - 0.032 13.7 0.1 0.067 12.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 AMD20297.1 - 0.086 12.0 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Pept_tRNA_hydro PF01195.14 AMD20298.1 - 7.5e-38 129.8 0.0 9.2e-38 129.5 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase SQS_PSY PF00494.14 AMD20299.1 - 6e-40 137.2 0.0 7.6e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Ku PF02735.11 AMD20300.1 - 1.3e-30 106.2 0.0 2.7e-30 105.2 0.0 1.5 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 AMD20300.1 - 8.1e-20 71.2 0.0 1.8e-19 70.1 0.0 1.6 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.9 AMD20300.1 - 0.00024 21.5 0.5 0.0012 19.2 0.0 2.3 2 1 0 2 2 2 1 Ku70/Ku80 C-terminal arm VWA PF00092.23 AMD20300.1 - 0.068 12.8 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain Sugar_tr PF00083.19 AMD20301.1 - 8.8e-42 143.2 21.4 1.1e-41 142.9 14.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD20301.1 - 9.3e-22 77.2 11.4 1.8e-12 46.6 7.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ost4 PF10215.4 AMD20301.1 - 0.15 11.5 6.3 6.6 6.3 1.3 2.8 2 0 0 2 2 2 0 Oligosaccaryltransferase Tubulin PF00091.20 AMD20302.1 - 4.5e-70 235.8 0.0 6.1e-70 235.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 AMD20302.1 - 1.4e-48 164.0 0.0 2.2e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain H-K_ATPase_N PF09040.6 AMD20302.1 - 0.074 13.1 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 Gastric H+/K+-ATPase, N terminal domain ALO PF04030.9 AMD20303.1 - 3.3e-100 334.9 0.6 8.3e-100 333.6 0.1 1.7 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 AMD20303.1 - 1e-27 96.2 0.0 1.5e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 AMD20304.1 - 4.9e-27 94.6 0.0 8.7e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 AMD20304.1 - 6.6e-27 93.5 0.0 1.1e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 AMD20304.1 - 2.1e-07 30.9 0.0 3.6e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 AMD20304.1 - 0.0033 17.3 0.0 0.0058 16.5 0.0 1.4 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain F-box-like PF12937.2 AMD20305.1 - 1.3e-10 40.8 0.0 2.5e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 AMD20305.1 - 1.4e-06 27.7 0.0 2.7e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain Abi PF02517.11 AMD20307.1 - 7e-14 51.7 3.5 7e-14 51.7 2.4 2.5 3 1 0 3 3 3 1 CAAX protease self-immunity Zds_C PF08632.5 AMD20308.1 - 1.7e-33 113.7 1.4 1.7e-33 113.7 1.0 1.8 2 0 0 2 2 2 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF1892 PF08987.5 AMD20309.1 - 5.7e-42 142.3 2.3 6.2e-42 142.2 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) Cyt-b5 PF00173.23 AMD20310.1 - 9.8e-15 54.1 0.2 1.9e-12 46.7 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 AMD20310.1 - 2.1e-10 40.9 24.7 2.5e-10 40.7 14.8 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.8 AMD20310.1 - 0.0033 17.4 0.4 0.0075 16.2 0.3 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Kua-UEV1_localn PF10520.4 AMD20310.1 - 2.3 7.8 13.0 2.5 7.7 1.7 2.5 1 1 0 2 2 2 0 Kua-ubiquitin conjugating enzyme hybrid localisation domain CPDase PF07823.6 AMD20311.1 - 1.1e-63 214.2 0.5 1.3e-63 214.1 0.3 1.0 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.1 AMD20311.1 - 0.0054 16.4 0.7 0.88 9.2 0.1 2.1 1 1 0 2 2 2 2 2'-5' RNA ligase superfamily DUF3051 PF11252.3 AMD20311.1 - 0.081 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) TFIIB PF00382.14 AMD20312.1 - 1.3e-53 178.7 1.7 4.6e-27 93.6 0.1 2.8 3 0 0 3 3 3 2 Transcription factor TFIIB repeat BRF1 PF07741.8 AMD20312.1 - 7.3e-33 112.6 0.4 7.3e-33 112.6 0.3 3.3 2 1 1 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.7 AMD20312.1 - 1.1e-11 43.8 3.1 1.9e-11 43.0 2.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 AMD20312.1 - 5.1e-06 26.0 0.6 0.094 12.2 0.1 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain zf-ribbon_3 PF13248.1 AMD20312.1 - 0.045 12.9 1.8 0.089 12.0 1.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 AMD20312.1 - 0.24 11.3 2.2 0.74 9.8 1.5 1.8 1 0 0 1 1 1 0 Zinc ribbon domain SDA1 PF05285.7 AMD20313.1 - 8.1e-87 291.5 44.1 8.1e-86 288.2 25.4 3.1 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.7 AMD20313.1 - 5.5e-22 77.7 0.1 1.5e-21 76.4 0.1 1.8 1 0 0 1 1 1 1 NUC130/3NT domain ATP-grasp_2 PF08442.5 AMD20314.1 - 2.7e-71 239.1 0.4 4e-71 238.5 0.3 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 AMD20314.1 - 1.9e-26 92.4 0.3 7.6e-26 90.5 0.1 2.2 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.1 AMD20314.1 - 0.00015 21.0 0.5 0.00026 20.2 0.3 1.5 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 AMD20314.1 - 0.0027 17.2 0.1 0.0079 15.7 0.1 1.7 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF1678 PF07913.6 AMD20314.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1678) Abhydrolase_1 PF00561.15 AMD20314.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold MPC PF03650.8 AMD20315.1 - 2.3e-48 163.0 0.2 2.5e-48 162.9 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) zf-CXXC PF02008.15 AMD20316.1 - 6.2 6.7 20.6 7.5 6.4 13.0 2.2 1 1 1 2 2 2 0 CXXC zinc finger domain ANTH PF07651.11 AMD20317.1 - 7.3e-59 198.7 0.1 7.3e-59 198.7 0.0 1.5 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.15 AMD20317.1 - 4.3e-07 29.8 0.0 2.7e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 ENTH domain PFK PF00365.15 AMD20318.1 - 4.2e-165 547.6 5.2 2.2e-121 404.1 1.5 2.1 2 0 0 2 2 2 2 Phosphofructokinase Pilus_CpaD PF09476.5 AMD20318.1 - 0.14 11.6 0.0 0.37 10.2 0.0 1.6 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) NTP_transf_2 PF01909.18 AMD20319.1 - 4.2e-15 55.8 0.0 1.7e-14 53.9 0.0 2.1 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.14 AMD20319.1 - 7.7e-14 51.3 0.7 1.7e-13 50.2 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase RF-1 PF00472.15 AMD20320.1 - 6.7e-16 58.1 0.9 1.2e-15 57.3 0.6 1.4 1 0 0 1 1 1 1 RF-1 domain CCDC50_N PF15295.1 AMD20320.1 - 0.38 10.6 6.0 0.051 13.4 1.0 1.8 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 50 N-terminus DUF4414 PF14377.1 AMD20320.1 - 0.39 10.6 2.3 0.73 9.7 1.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4414) MRP-S28 PF10213.4 AMD20320.1 - 0.9 9.6 6.5 2.5 8.1 4.5 1.8 1 1 0 1 1 1 0 Mitochondrial ribosomal subunit protein MADF_DNA_bdg PF10545.4 AMD20320.1 - 1.3 9.2 6.7 2.5 8.3 4.6 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Pkinase PF00069.20 AMD20321.1 - 5.3e-67 225.7 0.2 7.9e-67 225.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20321.1 - 1.1e-50 172.1 0.3 1.5e-50 171.6 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 AMD20321.1 - 2.1e-21 76.0 0.2 7.4e-21 74.3 0.1 2.1 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.1 AMD20321.1 - 5e-08 32.2 0.0 9.9e-08 31.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH PF00169.24 AMD20321.1 - 1.4e-06 28.4 1.7 3.9e-06 27.0 1.2 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 AMD20321.1 - 0.004 17.4 0.8 0.02 15.1 0.6 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain APH PF01636.18 AMD20321.1 - 0.0079 15.9 0.0 0.032 13.9 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 AMD20321.1 - 0.011 14.5 0.1 0.019 13.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Sec7_N PF12783.2 AMD20322.1 - 2e-35 121.7 7.7 2e-35 121.7 5.4 5.4 6 0 0 6 6 6 2 Guanine nucleotide exchange factor in Golgi transport N-terminal PalH PF08733.5 AMD20324.1 - 8.1e-60 202.4 13.1 1e-59 202.1 9.1 1.1 1 0 0 1 1 1 1 PalH/RIM21 RabGAP-TBC PF00566.13 AMD20325.1 - 4.6e-46 156.9 0.0 8.1e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ubiquitin PF00240.18 AMD20326.1 - 6.6e-05 22.2 0.1 0.00011 21.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 AMD20326.1 - 0.094 12.9 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain VirDNA-topo-I_N PF09266.5 AMD20326.1 - 0.21 11.4 0.7 0.37 10.7 0.1 1.6 2 0 0 2 2 2 0 Viral DNA topoisomerase I, N-terminal Erf4 PF10256.4 AMD20327.1 - 3.9e-29 100.8 0.0 5.3e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family ArdA PF07275.6 AMD20327.1 - 0.055 13.7 0.2 1.1 9.4 0.1 2.1 2 0 0 2 2 2 0 Antirestriction protein (ArdA) TruB_N PF01509.13 AMD20328.1 - 6.2e-43 146.5 0.2 4e-39 134.1 0.0 2.7 2 1 1 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) Mid1 PF12929.2 AMD20329.1 - 1.2e-119 399.8 6.0 1.5e-119 399.5 4.1 1.1 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.17 AMD20329.1 - 0.03 14.6 3.2 2 8.7 0.3 2.9 3 0 0 3 3 3 0 Fz domain AAA PF00004.24 AMD20330.1 - 2.1e-18 66.8 0.0 3.5e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 AMD20330.1 - 2e-17 63.3 0.1 4.6e-15 55.6 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 AMD20330.1 - 9.5e-13 47.9 0.1 2.6e-12 46.5 0.1 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_22 PF13401.1 AMD20330.1 - 6.8e-08 32.7 0.8 8.6e-05 22.6 0.3 2.7 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 AMD20330.1 - 3.3e-07 30.4 0.1 2.9e-06 27.4 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.10 AMD20330.1 - 9.7e-07 27.8 0.0 2.8e-05 23.0 0.0 2.2 1 1 0 2 2 2 1 Rad17 cell cycle checkpoint protein RuvB_N PF05496.7 AMD20330.1 - 1.1e-06 27.8 0.0 2.1e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 AMD20330.1 - 3.8e-06 26.8 0.0 7.2e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 AMD20330.1 - 7e-06 25.1 0.0 1.1e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.1 AMD20330.1 - 0.00021 20.9 0.2 0.00048 19.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD20330.1 - 0.00022 22.0 0.0 0.00084 20.1 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 AMD20330.1 - 0.00025 20.7 0.0 0.0011 18.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.1 AMD20330.1 - 0.00025 20.6 0.0 0.00063 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.8 AMD20330.1 - 0.00029 20.3 0.1 0.00052 19.5 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_19 PF13245.1 AMD20330.1 - 0.00036 20.2 0.0 0.00076 19.1 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_3 PF07726.6 AMD20330.1 - 0.0004 19.9 0.0 0.00079 19.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 AMD20330.1 - 0.00046 19.6 0.0 0.00086 18.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_10 PF12846.2 AMD20330.1 - 0.00072 19.0 0.1 0.72 9.2 0.0 2.4 1 1 1 2 2 2 2 AAA-like domain DEAD PF00270.24 AMD20330.1 - 0.00086 18.8 0.2 0.018 14.5 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_30 PF13604.1 AMD20330.1 - 0.0009 18.8 1.0 0.039 13.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 AMD20330.1 - 0.001 18.2 0.0 0.0058 15.8 0.0 2.0 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 AMD20330.1 - 0.0024 17.3 0.1 0.21 10.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 AMD20330.1 - 0.003 17.8 0.0 0.0067 16.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 AMD20330.1 - 0.0035 17.0 0.1 0.0084 15.8 0.1 1.5 1 0 0 1 1 1 1 Archaeal ATPase Viral_helicase1 PF01443.13 AMD20330.1 - 0.0043 16.5 0.0 0.0091 15.5 0.0 1.7 1 1 0 1 1 1 1 Viral (Superfamily 1) RNA helicase MobB PF03205.9 AMD20330.1 - 0.0062 16.2 0.0 0.013 15.1 0.0 1.7 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 AMD20330.1 - 0.0088 16.2 0.0 0.019 15.1 0.0 1.6 1 1 0 1 1 1 1 RNA helicase AAA_28 PF13521.1 AMD20330.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 AMD20330.1 - 0.012 15.4 0.0 0.36 10.6 0.0 2.4 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_33 PF13671.1 AMD20330.1 - 0.023 14.5 0.1 0.056 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.17 AMD20330.1 - 0.037 13.4 0.0 0.086 12.2 0.0 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_23 PF13476.1 AMD20330.1 - 0.041 14.1 0.4 0.12 12.6 0.2 1.6 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 AMD20330.1 - 0.073 12.0 0.0 0.17 10.7 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Cyclin_N PF00134.18 AMD20331.1 - 3e-20 72.0 0.0 4.7e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 AMD20331.1 - 9.3e-12 45.5 0.0 1.8e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Cyclin Secretin_N_2 PF07655.8 AMD20332.1 - 0.065 13.6 0.3 0.1 12.9 0.2 1.5 1 1 0 1 1 1 0 Secretin N-terminal domain RR_TM4-6 PF06459.7 AMD20332.1 - 0.55 10.0 15.8 0.61 9.9 10.9 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CMV_1a PF12467.3 AMD20332.1 - 5.4 7.3 13.0 6.6 7.0 9.0 1.1 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family TP53IP5 PF15331.1 AMD20332.1 - 8.5 6.2 10.3 9.5 6.0 7.2 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Rcd1 PF04078.8 AMD20333.1 - 4e-122 406.1 3.2 5.1e-122 405.7 2.2 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like PAT1 PF09770.4 AMD20333.1 - 0.078 11.2 13.5 0.1 10.7 9.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GET2 PF08690.5 AMD20333.1 - 0.31 10.2 1.9 0.47 9.6 1.3 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 TFIIA PF03153.8 AMD20333.1 - 9.8 5.9 9.9 15 5.3 6.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Adaptin_N PF01602.15 AMD20334.1 - 5e-104 348.5 12.7 7.2e-104 347.9 8.8 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 AMD20334.1 - 5.6e-47 159.3 0.6 1.2e-46 158.2 0.4 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 AMD20334.1 - 8.4e-09 35.6 0.1 0.3 11.4 0.0 5.4 2 1 3 5 5 5 3 HEAT repeats HEAT PF02985.17 AMD20334.1 - 0.00056 19.7 3.0 17 5.8 0.0 6.1 7 0 0 7 7 7 1 HEAT repeat Arm PF00514.18 AMD20334.1 - 0.03 14.1 0.4 1.7 8.5 0.1 4.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF3355 PF11835.3 AMD20334.1 - 0.042 13.6 1.7 0.073 12.8 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3355) vATP-synt_E PF01991.13 AMD20334.1 - 0.062 12.5 0.3 5.5 6.2 0.0 2.9 2 0 0 2 2 2 0 ATP synthase (E/31 kDa) subunit Pkinase PF00069.20 AMD20335.1 - 1.3e-46 158.8 0.0 2.3e-46 158.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20335.1 - 1e-29 103.3 0.0 1.7e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20335.1 - 0.057 12.3 0.0 0.47 9.3 0.0 2.1 2 0 0 2 2 2 0 Kinase-like APH PF01636.18 AMD20335.1 - 0.17 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mannosyl_trans3 PF11051.3 AMD20336.1 - 7e-81 271.5 0.0 1.1e-80 270.9 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative muHD PF10291.4 AMD20337.1 - 2.4e-62 210.4 0.0 4.4e-62 209.5 0.0 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain SSB PF00436.20 AMD20339.1 - 3.7e-18 65.3 0.0 4.4e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Gon7 PF08738.5 AMD20340.1 - 1.8e-31 108.1 0.1 2.1e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Gon7 family MutS_IV PF05190.13 AMD20340.1 - 0.11 12.6 0.1 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 MutS family domain IV MFS_1 PF07690.11 AMD20341.1 - 6.4e-29 100.7 22.0 6.4e-29 100.7 15.2 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Glyco_transf_34 PF05637.7 AMD20342.1 - 2e-47 161.6 0.1 2.7e-47 161.2 0.1 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family ATP12 PF07542.6 AMD20344.1 - 1.7e-31 108.6 0.0 3.2e-31 107.8 0.0 1.5 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.15 AMD20345.1 - 1.6e-15 56.7 4.1 1.7e-15 56.6 2.9 1.0 1 0 0 1 1 1 1 Prefoldin subunit GCM PF03615.10 AMD20345.1 - 0.048 13.2 0.0 0.061 12.9 0.0 1.2 1 0 0 1 1 1 0 GCM motif protein YlqD PF11068.3 AMD20345.1 - 1.5 8.8 6.3 3.6 7.6 2.4 2.0 2 0 0 2 2 2 0 YlqD protein ATG27 PF09451.5 AMD20346.1 - 6.2e-51 173.1 0.2 8.7e-51 172.7 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 FixP_N PF14715.1 AMD20346.1 - 1.2 8.5 7.2 0.23 10.8 2.6 1.5 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Ribosomal_L22 PF00237.14 AMD20347.1 - 3.6e-33 113.6 0.1 3.6e-33 113.6 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e CRT10 PF08728.5 AMD20347.1 - 0.1 10.5 0.3 0.11 10.4 0.2 1.0 1 0 0 1 1 1 0 CRT10 CASP_C PF08172.7 AMD20348.1 - 5.8e-66 222.0 8.2 5.8e-66 222.0 5.7 3.7 2 1 0 3 3 3 1 CASP C terminal ADIP PF11559.3 AMD20348.1 - 0.014 15.2 0.8 0.014 15.2 0.6 6.9 4 2 3 7 7 7 0 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.7 AMD20348.1 - 0.047 13.9 0.5 0.047 13.9 0.3 3.7 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein MCC-bdg_PDZ PF10506.4 AMD20348.1 - 0.22 11.3 22.0 1.4 8.7 3.4 5.6 4 1 1 5 5 5 0 PDZ domain of MCC-2 bdg protein for Usher syndrome ATG16 PF08614.6 AMD20348.1 - 4.1 7.1 62.8 0.22 11.3 12.4 5.4 2 1 3 5 5 5 0 Autophagy protein 16 (ATG16) SWIRM PF04433.12 AMD20349.1 - 1.1e-31 108.7 0.1 2.4e-31 107.6 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.26 AMD20349.1 - 6.5e-10 38.9 0.0 1.6e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD20349.1 - 1.7e-08 34.4 0.0 6.1e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF4511 PF14974.1 AMD20349.1 - 0.016 14.9 0.1 0.065 12.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4511) Usp PF00582.21 AMD20349.1 - 2 8.6 5.3 0.39 10.8 0.8 1.9 2 0 0 2 2 2 0 Universal stress protein family KRE9 PF05390.6 AMD20350.1 - 4.1e-19 68.9 6.1 8.8e-19 67.8 4.3 1.5 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 Rep_fac-A_3 PF08661.6 AMD20351.1 - 4.7e-26 90.8 0.0 5.3e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 PWI PF01480.12 AMD20352.1 - 0.16 12.1 0.1 0.47 10.5 0.0 1.8 2 0 0 2 2 2 0 PWI domain STE3 PF02076.10 AMD20353.1 - 1.7e-85 286.5 10.3 2.2e-85 286.2 7.1 1.1 1 0 0 1 1 1 1 Pheromone A receptor DUF2401 PF10287.4 AMD20354.1 - 2.8e-74 249.5 0.0 4.1e-74 249.0 0.0 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 AMD20354.1 - 6.9e-22 77.3 0.0 1.7e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) TFIIF_alpha PF05793.7 AMD20354.1 - 0.0019 16.6 34.7 0.0027 16.1 24.1 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CENP-T PF15511.1 AMD20354.1 - 0.11 11.6 21.4 0.16 11.1 14.8 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T SDA1 PF05285.7 AMD20354.1 - 1.7 7.8 35.4 3.8 6.7 24.5 1.6 1 0 0 1 1 1 0 SDA1 Daxx PF03344.10 AMD20354.1 - 5.9 5.2 35.4 9.1 4.6 24.5 1.2 1 0 0 1 1 1 0 Daxx Family Baculo_11_kDa PF06143.6 AMD20355.1 - 0.0066 15.7 0.2 0.012 14.9 0.1 1.5 1 0 0 1 1 1 1 Baculovirus 11 kDa family UPF0233 PF06781.7 AMD20355.1 - 0.13 11.9 0.8 1.1 8.9 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0233) SRI PF08236.6 AMD20356.1 - 1.8e-26 91.9 8.6 8.5e-26 89.7 5.9 2.3 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.23 AMD20356.1 - 5.4e-23 82.0 0.4 5.4e-23 82.0 0.2 3.5 2 2 0 2 2 2 1 SET domain IncA PF04156.9 AMD20356.1 - 8.3 5.9 17.4 18 4.8 12.0 1.6 1 0 0 1 1 1 0 IncA protein Zip PF02535.17 AMD20358.1 - 1.5e-21 76.7 8.7 5.9e-21 74.8 6.1 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1228 PF06779.9 AMD20358.1 - 0.17 11.9 2.6 0.55 10.2 1.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1228) Bax1-I PF01027.15 AMD20358.1 - 2 7.9 16.6 2.9 7.4 2.6 2.5 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 ABC2_membrane_4 PF12730.2 AMD20358.1 - 2 7.4 16.9 1.7 7.7 2.3 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein AA_permease PF00324.16 AMD20359.1 - 8.4e-51 172.7 42.2 1.1e-50 172.4 29.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD20359.1 - 4.2e-34 117.8 43.3 5e-34 117.5 30.0 1.0 1 0 0 1 1 1 1 Amino acid permease GTP_EFTU PF00009.22 AMD20360.1 - 6.4e-33 113.7 0.0 9.8e-33 113.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 AMD20360.1 - 1.2e-16 60.3 0.0 2.5e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 AMD20360.1 - 6.3e-14 51.6 0.0 1.5e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 AMD20360.1 - 1.3e-06 28.4 0.0 3.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 AMD20360.1 - 2.2e-05 24.1 0.0 5.5e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Miro PF08477.8 AMD20360.1 - 0.00019 21.8 0.0 0.00046 20.6 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 AMD20360.1 - 0.0042 17.0 0.0 0.0091 15.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 AMD20360.1 - 0.15 11.2 0.0 0.41 9.8 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF258 Ebp2 PF05890.7 AMD20361.1 - 3e-86 289.0 29.5 3e-86 289.0 20.4 2.4 1 1 2 3 3 3 1 Eukaryotic rRNA processing protein EBP2 Daxx PF03344.10 AMD20361.1 - 4.7 5.5 53.1 0.065 11.7 30.2 1.9 1 1 1 2 2 2 0 Daxx Family polyprenyl_synt PF00348.12 AMD20362.1 - 3.1e-78 262.2 0.0 3.6e-78 261.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase UcrQ PF02939.11 AMD20363.1 - 1.5e-37 127.2 1.1 1.7e-37 127.0 0.8 1.0 1 0 0 1 1 1 1 UcrQ family DUF2741 PF10890.3 AMD20363.1 - 0.098 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2741) Pkinase PF00069.20 AMD20364.1 - 2.2e-35 122.0 0.0 3.1e-23 82.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20364.1 - 5e-20 71.6 0.0 1.8e-16 59.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 AMD20364.1 - 0.0025 16.8 0.0 1.1 8.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Ribosomal_L14 PF00238.14 AMD20365.1 - 2.8e-41 140.0 2.0 3.2e-41 139.9 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Mitoc_L55 PF09776.4 AMD20365.1 - 0.056 13.0 0.2 0.083 12.4 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 Pkinase PF00069.20 AMD20366.1 - 4e-49 167.1 0.0 9e-49 165.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20366.1 - 7.2e-18 64.5 0.1 1.7e-17 63.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20366.1 - 0.016 14.1 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.15 AMD20366.1 - 0.056 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ral PF11058.3 AMD20366.1 - 0.094 12.1 0.0 0.25 10.7 0.0 1.7 1 0 0 1 1 1 0 Antirestriction protein Ral APH PF01636.18 AMD20366.1 - 0.23 11.1 0.0 0.45 10.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Gly-zipper_OmpA PF13436.1 AMD20366.1 - 0.49 10.0 9.4 0.047 13.3 3.3 1.7 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain LrgB PF04172.11 AMD20367.1 - 1.2e-17 63.7 7.7 1.2e-17 63.7 5.4 2.2 3 1 0 3 3 3 1 LrgB-like family LrgA PF03788.9 AMD20367.1 - 0.0074 15.9 3.0 0.0074 15.9 2.1 2.4 2 0 0 2 2 2 1 LrgA family L51_S25_CI-B8 PF05047.11 AMD20368.1 - 3.6e-15 55.4 0.6 7.4e-15 54.4 0.4 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF1310 PF07006.6 AMD20368.1 - 0.043 13.3 0.3 0.78 9.2 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1310) MFS_1 PF07690.11 AMD20369.1 - 1.4e-15 56.8 20.7 1.4e-15 56.8 14.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily GWT1 PF06423.7 AMD20369.1 - 0.49 10.4 8.1 1.5 8.9 0.2 3.4 2 1 1 3 3 3 0 GWT1 PigN PF04987.9 AMD20370.1 - 6.8e-129 430.3 37.4 9.7e-129 429.8 25.9 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 AMD20370.1 - 2e-15 56.9 0.1 2.4e-11 43.5 0.0 2.1 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 AMD20370.1 - 6.4e-11 41.9 0.1 9.4e-11 41.4 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 AMD20370.1 - 0.00022 20.6 0.0 0.00046 19.6 0.0 1.5 1 0 0 1 1 1 1 Metalloenzyme superfamily DnaJ PF00226.26 AMD20371.1 - 1.7e-19 69.2 0.7 5.3e-19 67.7 0.5 1.9 1 0 0 1 1 1 1 DnaJ domain CENP-F_leu_zip PF10473.4 AMD20371.1 - 1.4 8.7 6.2 0.3 10.9 0.5 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 5_3_exonuc PF01367.15 AMD20372.1 - 0.11 12.7 0.4 6 7.1 0.0 2.2 1 1 1 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold PIR PF00399.14 AMD20374.1 - 3.6e-13 48.3 30.3 0.0013 17.9 1.4 5.6 5 0 0 5 5 5 5 Yeast PIR protein repeat PIR PF00399.14 AMD20375.1 - 5.3e-07 28.7 14.9 4.5e-05 22.6 0.6 3.4 3 0 0 3 3 3 2 Yeast PIR protein repeat ATP-synt_ab PF00006.20 AMD20376.1 - 6.8e-63 212.0 0.0 1e-62 211.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 AMD20376.1 - 1.4e-26 93.2 0.2 2.4e-26 92.4 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 AMD20376.1 - 9.5e-23 80.2 2.6 9.5e-23 80.2 1.8 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain KaiC PF06745.8 AMD20376.1 - 0.0024 17.0 0.2 0.0038 16.3 0.1 1.3 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 AMD20376.1 - 0.0036 16.7 0.0 0.011 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 AMD20376.1 - 0.0048 16.6 0.1 0.56 9.9 0.0 2.9 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.17 AMD20376.1 - 0.011 14.6 0.7 0.52 9.1 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.7 AMD20376.1 - 0.024 14.2 0.2 0.074 12.7 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.1 AMD20376.1 - 0.04 13.8 0.4 0.19 11.6 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain DUF258 PF03193.11 AMD20376.1 - 0.054 12.6 0.1 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA PF00004.24 AMD20376.1 - 0.055 13.6 0.0 0.63 10.2 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 AMD20376.1 - 0.098 12.7 0.0 0.36 10.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 AMD20376.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Arch_ATPase PF01637.13 AMD20376.1 - 0.12 12.0 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase GCV_T PF01571.16 AMD20377.1 - 8.1e-08 31.8 0.0 0.00026 20.4 0.0 2.2 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 AMD20377.1 - 0.0029 17.5 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain UPF0104 PF03706.8 AMD20377.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) Ribosomal_S7 PF00177.16 AMD20378.1 - 1e-39 135.4 2.0 1.4e-39 135.0 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e MFS_1 PF07690.11 AMD20379.1 - 5.5e-26 91.1 24.4 1.1e-19 70.3 12.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 AMD20379.1 - 7.5e-15 54.2 22.3 4.1e-08 32.0 3.0 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.19 AMD20379.1 - 0.0012 17.5 21.8 0.0044 15.6 15.1 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.2 AMD20379.1 - 0.1 12.3 6.0 0.22 11.3 1.2 3.3 3 0 0 3 3 3 0 MFS_1 like family Zn_clus PF00172.13 AMD20380.1 - 7.1e-07 29.0 10.6 1.8e-06 27.7 7.4 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF753 PF05444.7 AMD20380.1 - 0.011 15.6 9.3 0.011 15.6 6.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF753) GTP_EFTU PF00009.22 AMD20381.1 - 1.1e-38 132.5 0.0 1.8e-38 131.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 AMD20381.1 - 1.8e-36 124.0 0.2 4e-36 122.9 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 AMD20381.1 - 7.6e-12 45.1 0.5 3.4e-11 43.1 0.3 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AMD20381.1 - 0.0069 16.3 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Connexin_CCC PF10582.4 AMD20381.1 - 1.3 8.8 3.6 1.4 8.7 1.7 1.7 1 1 0 1 1 1 0 Gap junction channel protein cysteine-rich domain RGS PF00615.14 AMD20382.1 - 5.3e-18 65.2 0.7 2.8e-10 40.3 0.1 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.16 AMD20382.1 - 3e-11 42.8 0.1 5.9e-08 32.3 0.0 2.8 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase PF00069.20 AMD20383.1 - 2.4e-73 246.4 0.0 3.2e-73 246.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20383.1 - 9.3e-32 110.1 0.0 9e-31 106.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20383.1 - 0.073 12.0 0.0 0.25 10.2 0.0 1.7 1 1 0 1 1 1 0 Kinase-like ORC4_C PF14629.1 AMD20384.1 - 7.2e-33 113.6 3.9 1.4e-32 112.7 2.7 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 AMD20384.1 - 4.5e-07 30.0 0.9 1.7e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 AMD20384.1 - 0.013 15.7 0.1 0.035 14.3 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FliG_C PF01706.11 AMD20384.1 - 0.015 15.2 0.7 0.082 12.8 0.1 2.4 2 0 0 2 2 2 0 FliG C-terminal domain FTHFS PF01268.14 AMD20384.1 - 0.043 11.8 0.1 0.071 11.0 0.1 1.2 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase RRM_6 PF14259.1 AMD20385.1 - 2.3e-07 30.6 0.0 4.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD20385.1 - 1.3e-05 24.7 0.0 3.4e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Herpes_UL7 PF01677.11 AMD20385.1 - 0.0065 15.8 0.0 0.0097 15.2 0.0 1.2 1 0 0 1 1 1 1 Herpesvirus UL7 like RRM_5 PF13893.1 AMD20385.1 - 0.0095 15.7 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pentapeptide PF00805.17 AMD20385.1 - 0.59 9.4 6.5 21 4.4 0.0 4.6 6 0 0 6 6 6 0 Pentapeptide repeats (8 copies) Fmp27_WPPW PF10359.4 AMD20386.1 - 5.1e-101 338.4 1.6 1.1e-100 337.3 1.1 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.4 AMD20386.1 - 4.6e-99 332.3 15.0 8.9e-99 331.4 10.4 1.5 1 0 0 1 1 1 1 Golgi-body localisation protein domain Fmp27 PF10344.4 AMD20386.1 - 5.5e-96 322.1 13.2 8.9e-96 321.4 9.1 1.3 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 DUF2405 PF10293.4 AMD20386.1 - 2.1e-51 173.7 0.9 6.4e-51 172.2 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_GFWDK PF10347.4 AMD20386.1 - 3.9e-51 173.0 0.0 8.3e-51 171.9 0.0 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_SW PF10305.4 AMD20386.1 - 1.3e-31 109.0 0.2 1.1e-30 106.0 0.0 2.9 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Ras PF00071.17 AMD20388.1 - 3.5e-52 176.0 0.0 4.2e-52 175.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD20388.1 - 3e-15 56.7 0.0 4.3e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD20388.1 - 3.6e-08 32.8 0.0 5.4e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 AMD20388.1 - 0.086 11.9 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ras PF00071.17 AMD20389.1 - 2.9e-55 186.0 0.0 3.4e-55 185.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD20389.1 - 2e-16 60.5 0.0 3.3e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD20389.1 - 7.6e-07 28.5 0.0 1.1e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD20389.1 - 6.9e-05 22.3 0.0 0.00029 20.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 AMD20389.1 - 0.014 14.5 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ribosomal_S14 PF00253.16 AMD20390.1 - 5.8e-18 64.0 0.2 9.5e-18 63.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DNA_pol_E_B PF04042.11 AMD20391.1 - 5e-49 166.3 0.3 7.6e-49 165.7 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF3398 PF11878.3 AMD20391.1 - 0.089 12.6 0.3 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) Prenyltrans PF00432.16 AMD20392.1 - 1.8e-61 203.2 5.5 3e-12 45.8 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 AMD20392.1 - 1.1e-43 148.2 0.0 2.1e-13 50.6 0.0 3.7 1 1 4 5 5 5 5 Prenyltransferase-like Prenyltrans_1 PF13243.1 AMD20392.1 - 8e-10 38.7 0.0 0.0013 18.7 0.0 3.5 2 1 1 3 3 3 2 Prenyltransferase-like A2M_comp PF07678.9 AMD20392.1 - 0.015 14.5 0.0 0.32 10.1 0.0 2.8 4 0 0 4 4 4 0 A-macroglobulin complement component WD40 PF00400.27 AMD20393.1 - 6.2e-59 193.9 12.6 2.3e-13 49.4 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 AMD20393.1 - 8.3e-08 32.1 0.0 0.0081 15.8 0.0 3.7 1 1 4 5 5 5 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 AMD20393.1 - 0.0016 17.6 0.1 1 8.4 0.0 3.1 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal HDA2-3 PF11496.3 AMD20394.1 - 1.9e-87 292.8 1.3 1.9e-87 292.8 0.9 3.0 2 1 1 4 4 4 1 Class II histone deacetylase complex subunits 2 and 3 DUF4201 PF13870.1 AMD20394.1 - 0.011 15.2 4.5 0.011 15.2 3.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Spc7 PF08317.6 AMD20394.1 - 0.032 12.9 28.1 0.29 9.7 13.4 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein IFT57 PF10498.4 AMD20394.1 - 0.045 12.4 24.1 0.19 10.4 16.7 1.9 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 IncA PF04156.9 AMD20394.1 - 0.27 10.8 33.8 0.019 14.5 12.4 2.6 1 1 1 2 2 2 0 IncA protein Phage_GPO PF05929.6 AMD20394.1 - 0.42 9.8 12.6 0.25 10.5 6.7 1.9 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Sec8_exocyst PF04048.9 AMD20394.1 - 0.85 9.2 16.4 3.6 7.2 5.7 3.5 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain Reo_sigmaC PF04582.7 AMD20394.1 - 2 7.4 10.3 1.3 8.1 4.0 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein FUSC PF04632.7 AMD20394.1 - 2.2 6.6 4.7 3.1 6.0 3.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family COG2 PF06148.6 AMD20394.1 - 6.7 6.5 19.4 4.2 7.2 5.9 3.5 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ThiF PF00899.16 AMD20395.1 - 1.4e-14 54.0 0.0 4.8e-14 52.3 0.0 1.8 2 0 0 2 2 2 1 ThiF family Sec23_trunk PF04811.10 AMD20396.1 - 1.7e-72 243.6 0.0 2.4e-72 243.2 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 AMD20396.1 - 1.1e-35 121.2 0.3 2.2e-35 120.2 0.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 AMD20396.1 - 3.3e-28 98.0 0.0 6.5e-28 97.0 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 AMD20396.1 - 1.8e-15 56.2 4.5 3.5e-15 55.2 3.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 AMD20396.1 - 7.1e-11 41.6 0.0 1.4e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Pterin_4a PF01329.14 AMD20396.1 - 0.11 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase zf-MIZ PF02891.15 AMD20396.1 - 0.17 11.4 1.0 0.34 10.4 0.7 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger PIG-U PF06728.8 AMD20397.1 - 7.1e-100 334.5 43.2 9e-100 334.1 29.9 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U LSM PF01423.17 AMD20398.1 - 3e-17 61.8 0.4 3.6e-17 61.6 0.3 1.1 1 0 0 1 1 1 1 LSM domain Glycos_transf_2 PF00535.21 AMD20399.1 - 2.8e-28 98.7 0.0 3.7e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AMD20399.1 - 2.3e-07 30.8 0.0 3.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 AMD20399.1 - 5.2e-06 25.7 0.0 7.1e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 hDGE_amylase PF14701.1 AMD20400.1 - 1.9e-157 524.5 0.2 2.6e-157 524.0 0.1 1.2 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme GDE_C PF06202.9 AMD20400.1 - 1.9e-109 365.7 0.0 2.7e-109 365.2 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.1 AMD20400.1 - 2e-60 204.1 0.0 3.1e-60 203.5 0.0 1.3 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 AMD20400.1 - 4.4e-17 61.6 0.1 1.1e-16 60.4 0.1 1.7 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.19 AMD20400.1 - 1.2e-08 34.7 1.1 8.3e-05 22.1 0.0 2.9 4 0 0 4 4 4 2 Alpha amylase, catalytic domain ATG13 PF10033.4 AMD20401.1 - 5.2e-67 225.6 0.2 9.3e-67 224.8 0.1 1.4 1 0 0 1 1 1 1 Autophagy-related protein 13 OPT PF03169.10 AMD20402.1 - 2.2e-163 545.0 51.4 2.5e-163 544.8 35.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3093 PF11292.3 AMD20402.1 - 0.41 10.4 6.4 1.9 8.2 4.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) DUF1282 PF06930.7 AMD20403.1 - 0.049 13.2 0.4 0.058 13.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) DUF202 PF02656.10 AMD20403.1 - 0.082 13.1 0.7 0.14 12.3 0.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF202) TRIC PF05197.8 AMD20403.1 - 0.29 10.5 2.5 0.51 9.7 1.7 1.6 1 1 0 1 1 1 0 TRIC channel PWWP PF00855.12 AMD20405.1 - 1.8e-15 56.8 1.0 3.6e-15 55.9 0.1 1.9 2 0 0 2 2 2 1 PWWP domain Sec10 PF07393.6 AMD20405.1 - 0.005 15.0 2.8 0.0071 14.5 1.9 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF3554 PF12074.3 AMD20405.1 - 0.032 13.6 0.2 0.045 13.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3554) CAML PF14963.1 AMD20405.1 - 0.066 12.5 4.0 0.098 12.0 2.8 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Pyridox_oxidase PF01243.15 AMD20406.1 - 2.4e-14 53.0 0.0 4.6e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.1 AMD20406.1 - 7.4e-05 22.5 0.1 0.00017 21.3 0.1 1.5 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase AAA PF00004.24 AMD20407.1 - 9.4e-44 148.8 0.0 2.1e-43 147.7 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 AMD20407.1 - 2.5e-29 100.9 0.2 2.8e-28 97.5 0.1 2.7 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 AMD20407.1 - 9.7e-22 76.6 3.5 3.1e-21 75.0 2.0 2.2 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_22 PF13401.1 AMD20407.1 - 1.7e-06 28.1 0.1 0.0071 16.4 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_17 PF13207.1 AMD20407.1 - 3.6e-06 27.7 0.0 2e-05 25.3 0.0 2.3 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 AMD20407.1 - 1.2e-05 24.5 0.0 1.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 AMD20407.1 - 1.2e-05 25.0 0.0 5.8e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 AMD20407.1 - 1.3e-05 25.1 0.0 4.3e-05 23.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 AMD20407.1 - 1.7e-05 24.3 0.0 5.2e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.1 AMD20407.1 - 2.9e-05 23.5 0.2 0.028 13.8 0.1 2.6 2 1 0 3 3 2 2 AAA domain AAA_16 PF13191.1 AMD20407.1 - 3.3e-05 23.9 0.3 0.00037 20.5 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.8 AMD20407.1 - 6e-05 21.9 0.0 9.9e-05 21.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus DUF815 PF05673.8 AMD20407.1 - 0.00011 21.2 0.0 0.0006 18.8 0.0 2.0 1 1 2 3 3 3 1 Protein of unknown function (DUF815) RNA_helicase PF00910.17 AMD20407.1 - 0.00014 21.9 0.4 0.0075 16.4 0.0 3.1 4 0 0 4 4 2 1 RNA helicase AAA_33 PF13671.1 AMD20407.1 - 0.0005 19.9 0.1 0.0015 18.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.9 AMD20407.1 - 0.00074 19.4 0.1 0.0031 17.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.7 AMD20407.1 - 0.0045 16.1 0.1 0.12 11.4 0.0 2.6 1 1 1 2 2 2 1 Zeta toxin AAA_18 PF13238.1 AMD20407.1 - 0.0058 16.9 0.0 0.015 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 AMD20407.1 - 0.011 14.8 0.0 3.9 6.5 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_24 PF13479.1 AMD20407.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Torsin PF06309.6 AMD20407.1 - 0.019 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Torsin Arch_ATPase PF01637.13 AMD20407.1 - 0.022 14.4 0.1 0.59 9.7 0.0 2.4 1 1 1 2 2 2 0 Archaeal ATPase Mg_chelatase PF01078.16 AMD20407.1 - 0.022 13.9 0.0 0.064 12.4 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 AMD20407.1 - 0.026 14.2 0.2 0.099 12.4 0.0 2.0 2 0 0 2 2 2 0 Part of AAA domain PhoH PF02562.11 AMD20407.1 - 0.035 13.3 0.1 0.084 12.0 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.7 AMD20407.1 - 0.062 12.9 0.0 0.69 9.5 0.0 2.2 1 1 1 2 2 2 0 NACHT domain NB-ARC PF00931.17 AMD20407.1 - 0.062 12.1 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.21 AMD20407.1 - 0.071 12.5 0.0 0.26 10.7 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain ResIII PF04851.10 AMD20407.1 - 0.079 12.7 0.1 0.38 10.5 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.12 AMD20407.1 - 0.08 11.8 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.1 AMD20407.1 - 0.08 12.9 0.0 0.22 11.5 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Use1 PF09753.4 AMD20407.1 - 0.084 12.3 0.4 0.15 11.4 0.3 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 CPT PF07931.7 AMD20407.1 - 0.1 12.2 0.4 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.1 AMD20407.1 - 0.11 12.5 0.2 0.29 11.0 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_10 PF12846.2 AMD20407.1 - 0.11 11.9 0.2 4.7 6.5 0.0 2.6 2 1 1 3 3 2 0 AAA-like domain AAA_21 PF13304.1 AMD20407.1 - 0.17 11.7 0.3 2.2 8.1 0.0 2.2 1 1 1 2 2 2 0 AAA domain NBP1 PF08537.5 AMD20408.1 - 1.4e-98 330.1 23.9 1.5e-98 329.9 16.6 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 Peptidase_S10 PF00450.17 AMD20409.1 - 7.8e-103 344.8 0.0 1e-102 344.4 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase PAPS_reduct PF01507.14 AMD20410.1 - 4.4e-34 117.7 0.0 5.8e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Med10 PF09748.4 AMD20411.1 - 2.9e-46 156.4 0.3 3.8e-46 156.0 0.2 1.2 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Ribosomal_L50 PF10501.4 AMD20411.1 - 0.026 14.4 0.1 1.1 9.2 0.0 2.3 1 1 0 2 2 2 0 Ribosomal subunit 39S D123 PF07065.9 AMD20411.1 - 0.044 12.8 0.1 0.094 11.7 0.0 1.5 2 0 0 2 2 2 0 D123 WD40 PF00400.27 AMD20412.1 - 6.3e-05 22.7 2.7 0.15 12.0 0.1 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat OPT PF03169.10 AMD20413.1 - 8.4e-177 589.3 59.7 9.6e-177 589.1 41.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein SNAP PF14938.1 AMD20414.1 - 4e-101 337.8 15.1 4.6e-101 337.6 10.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 AMD20414.1 - 1.2e-05 24.8 14.5 0.17 11.5 0.4 3.5 1 1 2 3 3 3 3 TPR repeat TPR_12 PF13424.1 AMD20414.1 - 0.0026 17.6 13.5 0.92 9.4 0.2 4.4 1 1 4 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20414.1 - 0.0046 16.7 9.8 5.8 7.0 0.2 6.1 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 AMD20414.1 - 0.0076 16.6 9.1 5.1 7.7 0.0 5.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 AMD20414.1 - 0.098 13.3 6.1 32 5.5 0.0 4.9 2 2 2 4 4 4 0 Tetratricopeptide repeat NSF PF02071.15 AMD20414.1 - 0.27 11.9 12.9 7.5 7.6 0.1 6.8 8 0 0 8 8 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_1 PF00515.23 AMD20414.1 - 0.95 9.1 8.5 11 5.8 0.1 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 AMD20414.1 - 1.2 9.9 9.6 3 8.6 0.4 3.5 2 1 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 AMD20414.1 - 1.6 8.9 11.2 1.5 9.0 3.5 3.3 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 AMD20414.1 - 6.1 6.8 12.1 13 5.8 0.6 5.0 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 AMD20414.1 - 8.8 6.7 19.4 0.46 10.8 0.8 4.1 3 2 1 4 4 4 0 Tetratricopeptide repeat NAD_binding_6 PF08030.7 AMD20415.1 - 1.2e-20 74.0 0.0 2.3e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 AMD20415.1 - 2.2e-20 72.4 0.0 4.1e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 AMD20415.1 - 1.3e-13 51.1 17.7 1.3e-13 51.1 12.3 2.9 2 1 0 2 2 2 1 Ferric reductase like transmembrane component Yippee-Mis18 PF03226.9 AMD20416.1 - 1.4e-17 63.5 5.6 1.7e-17 63.2 3.9 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Inhibitor_I67 PF11405.3 AMD20416.1 - 0.21 11.6 0.4 0.21 11.6 0.3 2.4 4 0 0 4 4 4 0 Bromelain inhibitor VI Myotub-related PF06602.9 AMD20417.1 - 2.4e-130 434.4 2.2 3.1e-130 434.0 1.5 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.22 AMD20417.1 - 0.0041 16.5 0.0 0.0072 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 AMD20417.1 - 0.0092 16.2 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family GRAM PF02893.15 AMD20417.1 - 0.012 15.1 0.0 0.031 13.7 0.0 1.7 1 0 0 1 1 1 0 GRAM domain CMD PF02627.15 AMD20418.1 - 0.0041 16.9 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Proteasom_PSMB PF10508.4 AMD20418.1 - 0.027 12.7 0.0 0.046 12.0 0.0 1.3 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Nnf1 PF03980.9 AMD20419.1 - 2.2e-28 98.4 2.6 4.8e-28 97.3 1.8 1.6 1 0 0 1 1 1 1 Nnf1 DUF342 PF03961.8 AMD20419.1 - 0.0015 17.0 3.6 0.0021 16.5 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF342) Not3 PF04065.10 AMD20419.1 - 0.0055 16.0 3.0 0.04 13.2 0.0 2.4 2 1 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component DUF1640 PF07798.6 AMD20419.1 - 0.036 14.1 1.7 0.042 13.9 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Baculo_PEP_C PF04513.7 AMD20419.1 - 0.037 13.8 2.9 0.039 13.7 1.0 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.4 AMD20419.1 - 0.041 14.0 1.8 0.041 14.0 1.2 2.1 3 0 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TcdB_N PF12918.2 AMD20419.1 - 0.085 12.9 6.4 3.3 7.8 0.1 3.1 2 1 0 2 2 2 0 TcdB toxin N-terminal helical domain V_ATPase_I PF01496.14 AMD20419.1 - 0.16 9.7 1.7 0.19 9.5 1.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1366 PF07104.6 AMD20419.1 - 0.21 11.1 4.2 4.8 6.8 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1366) DUF1664 PF07889.7 AMD20419.1 - 0.65 9.8 5.9 0.1 12.4 0.7 2.1 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.10 AMD20419.1 - 0.89 9.2 5.3 0.51 10.0 1.8 2.0 2 1 0 2 2 2 0 RasGAP C-terminus MbeB_N PF04837.7 AMD20419.1 - 1 9.5 5.6 0.68 10.0 0.4 2.7 3 0 0 3 3 2 0 MbeB-like, N-term conserved region Prefoldin PF02996.12 AMD20419.1 - 1.1 8.8 8.5 0.11 12.1 1.6 2.4 3 0 0 3 3 3 0 Prefoldin subunit DUF16 PF01519.11 AMD20419.1 - 1.3 9.2 4.5 5.2 7.3 3.0 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF4404 PF14357.1 AMD20419.1 - 1.7 9.0 8.6 0.092 13.1 1.0 2.4 4 0 0 4 4 2 0 Domain of unknown function (DUF4404) IncA PF04156.9 AMD20419.1 - 2.6 7.6 13.1 0.32 10.5 3.2 2.4 2 2 0 2 2 2 0 IncA protein DASH_Dam1 PF08653.5 AMD20419.1 - 3.4 7.4 5.1 1.1 9.0 0.8 2.3 3 0 0 3 3 2 0 DASH complex subunit Dam1 EF-hand_4 PF12763.2 AMD20420.1 - 2.1e-30 104.5 0.0 5.9e-10 38.8 0.0 3.8 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 AMD20420.1 - 3e-10 40.1 0.1 0.00059 19.9 0.0 4.2 2 2 1 3 3 3 3 EF-hand domain pair UBA PF00627.26 AMD20420.1 - 6.7e-09 35.3 0.1 1.3e-08 34.4 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_1 PF00036.27 AMD20420.1 - 2.1e-07 29.7 0.1 0.029 13.6 0.0 4.6 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 AMD20420.1 - 8e-06 25.3 6.3 0.37 10.7 0.0 5.5 6 0 0 6 6 6 2 EF-hand domain UBA_4 PF14555.1 AMD20420.1 - 0.0042 16.5 1.1 0.0096 15.4 0.8 1.7 1 0 0 1 1 1 1 UBA-like domain EF-hand_8 PF13833.1 AMD20420.1 - 0.015 14.9 0.1 13 5.4 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_5 PF13202.1 AMD20420.1 - 0.22 10.9 1.9 10 5.6 0.0 3.9 4 0 0 4 4 4 0 EF hand VanZ PF04892.7 AMD20421.1 - 8.9e-05 22.4 2.8 0.00029 20.7 1.9 2.0 1 1 0 1 1 1 1 VanZ like family Ribosomal_S7 PF00177.16 AMD20422.1 - 5e-31 107.2 0.3 8.2e-31 106.5 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e PPP4R2 PF09184.6 AMD20423.1 - 1.9e-42 145.8 18.2 1.9e-42 145.8 12.6 2.7 1 1 1 2 2 2 1 PPP4R2 CDC45 PF02724.9 AMD20423.1 - 7.8 4.3 11.1 11 3.9 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M16_C PF05193.16 AMD20424.1 - 2.3e-23 82.8 0.2 7.2e-23 81.2 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 AMD20424.1 - 5.6e-21 74.8 0.6 1.1e-20 73.8 0.4 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) HOOK PF05622.7 AMD20424.1 - 0.015 13.1 0.0 0.025 12.4 0.0 1.2 1 0 0 1 1 1 0 HOOK protein LigB PF02900.13 AMD20424.1 - 0.11 11.4 0.3 7 5.5 0.0 3.1 3 1 1 4 4 4 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase Peptidase_M20 PF01546.23 AMD20426.1 - 2.6e-22 79.2 0.0 3.4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 AMD20426.1 - 1.1e-10 41.2 0.0 2e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Proteasome PF00227.21 AMD20427.1 - 5.2e-37 126.9 0.1 4.6e-36 123.8 0.1 1.9 1 1 0 1 1 1 1 Proteasome subunit Phage_Coat_B PF05356.6 AMD20427.1 - 0.016 14.8 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Phage Coat protein B ER_lumen_recept PF00810.13 AMD20428.1 - 1.1e-49 168.7 14.5 1.6e-49 168.1 10.1 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor Sdh_cyt PF01127.17 AMD20428.1 - 0.023 14.5 1.1 0.023 14.5 0.8 2.2 2 2 1 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF441 PF04284.8 AMD20428.1 - 1.9 8.3 5.2 0.46 10.3 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF441) Sod_Cu PF00080.15 AMD20430.1 - 2.9e-48 163.6 2.7 3.4e-48 163.4 1.9 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CTP_synth_N PF06418.9 AMD20431.1 - 1.6e-117 391.5 0.1 2.3e-117 390.9 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 AMD20431.1 - 1.9e-58 197.0 0.0 2.9e-58 196.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AMD20431.1 - 0.00018 21.0 0.0 0.00057 19.4 0.0 1.8 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.18 AMD20431.1 - 0.0027 17.1 0.0 0.0054 16.1 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain BAR_2 PF10455.4 AMD20432.1 - 0.014 14.2 0.3 0.017 14.0 0.2 1.2 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking IncA PF04156.9 AMD20432.1 - 0.76 9.3 5.5 1.1 8.8 3.8 1.2 1 0 0 1 1 1 0 IncA protein ESCRT-II PF05871.7 AMD20433.1 - 2.5e-42 144.0 0.2 3.7e-42 143.5 0.2 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit Sod_Fe_C PF02777.13 AMD20434.1 - 3.7e-14 52.4 2.5 2.7e-07 30.3 0.1 2.3 1 1 1 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Peptidase_C12 PF01088.16 AMD20435.1 - 5.6e-55 185.8 0.0 8.1e-55 185.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF1042 PF06294.6 AMD20435.1 - 0.034 13.7 0.2 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1042) SAC3_GANP PF03399.11 AMD20436.1 - 5.1e-51 173.1 7.1 8.8e-51 172.3 4.9 1.4 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 AMD20436.1 - 0.0019 17.9 3.8 0.0037 17.0 2.6 1.4 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Peptidase_C12 PF01088.16 AMD20437.1 - 8.3e-52 175.4 0.0 9.9e-52 175.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF3115 PF11312.3 AMD20437.1 - 0.033 13.0 0.0 0.051 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3115) PX PF00787.19 AMD20438.1 - 0.00011 21.9 0.0 0.00024 20.8 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.12 AMD20438.1 - 0.0042 16.5 0.1 0.17 11.3 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain Aldo_ket_red PF00248.16 AMD20439.1 - 3.2e-51 173.8 0.0 4.3e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family LMBR1 PF04791.11 AMD20440.1 - 4.2 5.8 7.4 0.1 11.1 0.5 1.6 2 0 0 2 2 2 0 LMBR1-like membrane protein Mito_carr PF00153.22 AMD20441.1 - 7.6e-68 224.2 2.7 3.7e-22 77.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L37ae PF01780.14 AMD20442.1 - 1.3e-39 133.9 9.4 1.5e-39 133.7 6.5 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Rep_fac-A_C PF08646.5 AMD20442.1 - 0.0088 15.7 0.4 0.01 15.5 0.3 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain Zn_Tnp_IS1595 PF12760.2 AMD20442.1 - 0.023 14.4 2.4 0.038 13.8 1.7 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF1364 PF07102.7 AMD20442.1 - 0.023 14.5 1.0 0.03 14.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1364) Sgf11 PF08209.6 AMD20442.1 - 0.045 13.0 0.5 0.9 8.9 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) A2L_zn_ribbon PF08792.5 AMD20442.1 - 0.062 12.7 2.7 2.5 7.6 0.3 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-C4_ClpX PF06689.8 AMD20442.1 - 0.13 11.7 0.3 0.13 11.7 0.2 2.0 2 0 0 2 2 2 0 ClpX C4-type zinc finger zf-H2C2_2 PF13465.1 AMD20442.1 - 0.15 12.4 0.6 1.8 8.9 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain C1_1 PF00130.17 AMD20442.1 - 0.17 11.6 1.8 0.26 11.0 1.2 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CarbpepA_inh PF02977.10 AMD20442.1 - 0.18 11.4 3.7 1.5 8.4 2.6 2.1 1 1 0 1 1 1 0 Carboxypeptidase A inhibitor C1_2 PF03107.11 AMD20442.1 - 0.21 11.7 1.9 4.2 7.5 0.2 2.2 2 0 0 2 2 2 0 C1 domain zf-MYND PF01753.13 AMD20442.1 - 0.41 10.5 2.7 0.73 9.7 1.9 1.4 1 0 0 1 1 1 0 MYND finger Beta-TrCP_D PF12125.3 AMD20443.1 - 0.014 15.0 0.0 0.032 13.8 0.0 1.6 1 0 0 1 1 1 0 D domain of beta-TrCP Fip1 PF05182.8 AMD20444.1 - 1.1e-23 82.1 0.5 1.9e-23 81.4 0.4 1.4 1 0 0 1 1 1 1 Fip1 motif TFIIF_alpha PF05793.7 AMD20444.1 - 0.083 11.2 11.4 0.15 10.4 7.9 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.7 AMD20444.1 - 1.5 6.6 13.2 1.8 6.3 9.1 1.1 1 0 0 1 1 1 0 Nop14-like family Anillin PF08174.6 AMD20445.1 - 5.4e-09 36.2 0.0 1.8e-08 34.5 0.0 1.9 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.24 AMD20445.1 - 0.0017 18.5 7.1 0.0021 18.2 0.0 3.4 2 1 0 2 2 2 1 PH domain PUF PF00806.14 AMD20446.1 - 1.8e-29 99.5 1.6 0.0001 21.5 0.0 6.8 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat RRM_5 PF13893.1 AMD20446.1 - 0.00014 21.6 0.0 0.00031 20.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD20446.1 - 0.00023 20.7 0.0 0.00062 19.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MAM1 PF10434.4 AMD20447.1 - 7.5e-63 212.2 15.5 2.7e-62 210.4 10.7 1.7 1 1 0 1 1 1 1 Monopolin complex protein MAM1 Pfg27 PF09216.5 AMD20447.1 - 0.0074 15.9 1.0 0.016 14.8 0.7 1.5 1 0 0 1 1 1 1 Pfg27 GatB_N PF02934.10 AMD20448.1 - 5.3e-98 327.4 0.0 8.1e-98 326.8 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 AMD20448.1 - 5.6e-26 91.0 0.1 1.1e-25 90.0 0.0 1.4 1 0 0 1 1 1 1 GatB domain WD40 PF00400.27 AMD20450.1 - 9.6e-30 101.3 7.5 7.8e-07 28.7 0.0 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.3 AMD20450.1 - 0.00012 20.3 0.2 0.0042 15.3 0.1 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 DUF3312 PF11768.3 AMD20450.1 - 0.16 10.1 0.1 0.93 7.6 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3312) LisH PF08513.6 AMD20451.1 - 1.5e-07 30.8 0.4 2.9e-07 29.9 0.3 1.5 1 0 0 1 1 1 1 LisH ALG3 PF05208.8 AMD20452.1 - 1.6e-119 399.4 29.6 2e-119 399.1 20.5 1.0 1 0 0 1 1 1 1 ALG3 protein HEAT_EZ PF13513.1 AMD20453.1 - 3.1e-17 62.5 0.0 0.0018 18.7 0.0 8.4 7 1 1 8 8 8 3 HEAT-like repeat HEAT_2 PF13646.1 AMD20453.1 - 9.6e-14 51.4 4.2 0.0014 18.8 0.0 6.4 5 2 0 5 5 5 3 HEAT repeats HEAT PF02985.17 AMD20453.1 - 1.3e-12 46.6 2.0 0.15 12.1 0.0 8.0 8 0 0 8 8 8 3 HEAT repeat IBN_N PF03810.14 AMD20453.1 - 8.5e-09 35.2 4.1 1.6e-06 27.9 0.0 4.2 4 0 0 4 4 4 1 Importin-beta N-terminal domain CLASP_N PF12348.3 AMD20453.1 - 1.9e-06 27.4 1.9 0.98 8.7 0.0 4.6 6 0 0 6 6 6 3 CLASP N terminal RIX1 PF08167.7 AMD20453.1 - 1.6e-05 24.6 1.6 0.0025 17.5 0.1 3.9 3 2 1 4 4 4 1 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.2 AMD20453.1 - 2.1e-05 24.8 7.5 1.1 9.7 0.0 6.6 7 1 1 8 8 8 1 Vacuolar 14 Fab1-binding region Ipi1_N PF12333.3 AMD20453.1 - 3.8e-05 23.5 0.3 0.2 11.6 0.0 5.1 4 1 1 5 5 5 1 Rix1 complex component involved in 60S ribosome maturation CD99L2 PF12301.3 AMD20453.1 - 0.066 12.9 1.0 0.57 9.8 0.2 2.3 2 0 0 2 2 2 0 CD99 antigen like protein 2 PAD_M PF08527.5 AMD20453.1 - 0.086 12.2 0.2 0.27 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain Ank_4 PF13637.1 AMD20454.1 - 2.9e-09 37.1 4.2 0.0012 19.3 0.3 3.1 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD20454.1 - 5.1e-09 36.3 1.8 0.0055 17.0 0.0 3.1 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 AMD20454.1 - 3.2e-08 33.5 1.6 0.0083 16.3 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) KilA-N PF04383.8 AMD20454.1 - 9e-08 31.7 0.6 5.1e-07 29.2 0.4 2.3 1 1 0 1 1 1 1 KilA-N domain Ank PF00023.25 AMD20454.1 - 2.1e-07 30.4 2.4 0.017 14.8 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 AMD20454.1 - 2e-05 24.3 4.0 0.081 13.2 0.0 4.2 4 1 1 5 5 5 2 Ankyrin repeat FlaC_arch PF05377.6 AMD20454.1 - 0.027 14.3 1.2 0.099 12.5 0.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) LSM PF01423.17 AMD20455.1 - 9.2e-16 57.1 0.1 1.7e-15 56.3 0.1 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 AMD20455.1 - 0.0094 15.8 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain EMP70 PF02990.11 AMD20456.1 - 4.4e-62 210.2 14.6 2.7e-60 204.3 10.1 2.2 1 1 0 1 1 1 1 Endomembrane protein 70 TPR_2 PF07719.12 AMD20457.1 - 3e-45 148.5 12.0 1.8e-07 30.5 0.0 10.4 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_11 PF13414.1 AMD20457.1 - 3.3e-42 141.9 21.7 5.9e-14 51.4 2.9 8.2 3 2 6 9 9 9 6 TPR repeat Apc3 PF12895.2 AMD20457.1 - 2.6e-38 130.0 27.6 5.2e-23 80.9 3.4 5.1 4 1 1 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 AMD20457.1 - 1e-37 126.2 20.4 3.6e-08 32.6 0.0 9.5 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20457.1 - 1.5e-30 102.6 10.8 5.8e-05 22.5 0.3 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.1 AMD20457.1 - 4.2e-27 94.1 4.0 2.4e-07 31.2 0.0 6.5 5 2 1 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 AMD20457.1 - 1.8e-23 82.2 24.1 1.6e-06 27.9 1.0 7.8 4 2 4 8 8 8 6 Tetratricopeptide repeat TPR_17 PF13431.1 AMD20457.1 - 2e-22 77.4 20.6 3.2e-05 23.7 0.2 9.1 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 AMD20457.1 - 3.6e-21 73.7 1.5 0.025 15.2 0.0 8.8 4 3 4 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.1 AMD20457.1 - 4.3e-17 62.2 6.7 5.2e-05 23.5 0.0 5.6 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.1 AMD20457.1 - 3.8e-15 55.2 19.5 0.044 14.2 0.0 10.1 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_7 PF13176.1 AMD20457.1 - 8.2e-15 53.3 6.6 0.26 11.1 0.0 8.6 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_15 PF13429.1 AMD20457.1 - 8.1e-11 41.4 4.3 0.0091 15.0 0.0 5.0 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.1 AMD20457.1 - 2.5e-05 24.0 1.2 0.32 10.8 0.0 4.9 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 AMD20457.1 - 3.8e-05 23.4 6.5 1.4 8.9 0.0 6.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_4 PF07721.9 AMD20457.1 - 0.00016 21.7 0.3 3.9 8.1 0.0 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat DUF3856 PF12968.2 AMD20457.1 - 0.00057 19.7 0.5 1.3 8.8 0.2 5.0 3 1 1 4 4 4 1 Domain of Unknown Function (DUF3856) TPR_3 PF07720.7 AMD20457.1 - 0.00063 19.4 14.3 0.058 13.2 1.4 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.1 AMD20457.1 - 0.00096 19.2 0.2 40 4.4 0.0 4.9 3 2 2 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.12 AMD20457.1 - 0.0064 16.8 0.0 0.29 11.4 0.0 2.9 2 1 1 3 3 2 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.1 AMD20457.1 - 0.52 10.2 17.3 2.9 7.8 0.5 6.2 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat TFIIA PF03153.8 AMD20457.1 - 0.94 9.3 12.7 1.4 8.7 8.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MIT PF04212.13 AMD20457.1 - 0.95 9.3 5.5 23 4.9 0.0 4.9 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain PPR PF01535.15 AMD20457.1 - 2.9 8.0 8.1 32 4.7 0.0 4.5 5 0 0 5 5 4 0 PPR repeat PH PF00169.24 AMD20458.1 - 2.2e-13 50.3 0.0 7.3e-13 48.6 0.0 2.0 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.23 AMD20458.1 - 3.1e-13 48.8 0.3 7.4e-13 47.6 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.12 AMD20458.1 - 9.9e-13 47.7 0.0 1.7e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.1 AMD20458.1 - 2.9e-09 36.3 0.1 5.5e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.1 AMD20458.1 - 9e-08 32.3 0.0 2.8e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain SAM_1 PF00536.25 AMD20458.1 - 9.2e-08 32.1 0.0 1.6e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.12 AMD20458.1 - 0.00025 20.4 0.0 0.00052 19.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_8 PF15409.1 AMD20458.1 - 0.0027 17.7 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain NT-C2 PF10358.4 AMD20459.1 - 2.4e-39 134.0 0.0 3.9e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DUF330 PF03886.8 AMD20459.1 - 0.082 12.2 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF330) zf-C3HC4 PF00097.20 AMD20461.1 - 6.6e-11 41.6 4.3 1.1e-10 40.9 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD20461.1 - 5.8e-10 38.6 4.7 9.3e-10 38.0 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD20461.1 - 3.6e-09 36.3 6.6 6.2e-09 35.5 4.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 AMD20461.1 - 8.7e-08 32.0 6.6 1.5e-07 31.2 4.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD20461.1 - 1e-07 31.5 5.5 1.8e-07 30.7 3.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 AMD20461.1 - 2.2e-05 24.0 3.6 4.3e-05 23.1 2.5 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 AMD20461.1 - 0.00027 20.7 5.4 0.00076 19.2 3.8 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 AMD20461.1 - 0.0022 17.7 1.7 0.0034 17.1 1.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 AMD20461.1 - 0.024 14.7 2.8 0.074 13.1 2.0 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger zf-RING_4 PF14570.1 AMD20461.1 - 0.038 13.5 5.6 0.14 11.7 4.0 1.9 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.7 AMD20461.1 - 0.63 10.2 3.9 4.2 7.5 1.0 2.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ribosomal_L14 PF00238.14 AMD20462.1 - 1e-31 109.2 0.0 1.1e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e PI3_PI4_kinase PF00454.22 AMD20463.1 - 1e-47 162.6 0.0 2.2e-47 161.5 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.3 AMD20463.1 - 6.2e-28 97.4 4.6 6.2e-28 97.4 3.2 3.7 4 0 0 4 4 4 1 Telomere-length maintenance and DNA damage repair FATC PF02260.15 AMD20463.1 - 1.1e-12 47.1 0.1 6.4e-12 44.7 0.0 2.4 2 0 0 2 2 2 1 FATC domain SH3_1 PF00018.23 AMD20464.1 - 9.1e-10 37.7 0.1 1.8e-09 36.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 AMD20464.1 - 1.1e-09 37.7 0.0 1.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 AMD20464.1 - 1.1e-08 34.3 0.0 2.4e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain 7TMR-DISM_7TM PF07695.6 AMD20464.1 - 0.006 16.2 7.8 0.008 15.8 5.4 1.1 1 0 0 1 1 1 1 7TM diverse intracellular signalling Aa_trans PF01490.13 AMD20465.1 - 4.4e-101 338.3 25.6 5.4e-101 338.0 17.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ribosomal_S21 PF01165.15 AMD20466.1 - 1.7e-11 43.3 3.3 2.9e-11 42.6 2.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 Peptidase_M24 PF00557.19 AMD20467.1 - 1.1e-53 181.8 0.3 1.4e-53 181.5 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Motile_Sperm PF00635.21 AMD20468.1 - 4.5e-26 90.6 0.2 9.5e-26 89.5 0.1 1.6 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Ribosomal_L32e PF01655.13 AMD20469.1 - 2.8e-45 152.8 2.3 3.3e-45 152.6 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 DUF3437 PF11919.3 AMD20469.1 - 0.13 11.9 0.3 0.25 11.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) Rox3 PF08633.5 AMD20470.1 - 1.1e-60 205.2 1.1 1.2e-60 205.0 0.8 1.0 1 0 0 1 1 1 1 Rox3 mediator complex subunit ArfGap PF01412.13 AMD20471.1 - 1.5e-34 118.2 0.8 3.2e-34 117.2 0.1 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf GATase PF00117.23 AMD20471.1 - 0.07 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Lysozyme_like PF13702.1 AMD20471.1 - 0.11 11.9 2.3 0.14 11.6 0.2 2.2 2 0 0 2 2 2 0 Lysozyme-like 4HBT PF03061.17 AMD20472.1 - 9.9e-06 25.5 0.0 2.2e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Thioesterase superfamily FAD_binding_3 PF01494.14 AMD20473.1 - 1.3e-17 63.9 0.0 2.5e-17 62.9 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 AMD20473.1 - 6e-08 31.9 0.0 4e-05 22.6 0.0 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.17 AMD20473.1 - 1.9e-05 23.7 0.0 3.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 AMD20473.1 - 3.7e-05 23.6 0.0 8.7e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 AMD20473.1 - 5.7e-05 23.4 0.0 0.00041 20.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 AMD20473.1 - 6.1e-05 22.9 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 AMD20473.1 - 0.00029 19.7 0.3 0.0012 17.6 0.0 1.9 2 0 0 2 2 2 1 Squalene epoxidase FAD_binding_2 PF00890.19 AMD20473.1 - 0.00083 18.3 0.0 0.0056 15.5 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.13 AMD20473.1 - 0.0017 18.0 0.0 0.0028 17.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 AMD20473.1 - 0.002 17.9 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 AMD20473.1 - 0.0036 16.7 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.9 AMD20473.1 - 0.013 13.9 0.0 0.02 13.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_2 PF03446.10 AMD20473.1 - 0.044 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Trp_halogenase PF04820.9 AMD20473.1 - 0.046 12.3 0.0 2.4 6.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase FAD_oxidored PF12831.2 AMD20473.1 - 0.06 12.4 0.1 0.1 11.6 0.1 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 AMD20473.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Cnd2 PF05786.9 AMD20474.1 - 1.4e-126 423.8 25.7 5.5e-126 421.9 17.8 1.7 1 1 0 1 1 1 1 Condensin complex subunit 2 Nuc_rec_co-act PF08815.5 AMD20474.1 - 0.0043 16.5 0.2 0.17 11.4 0.2 2.5 2 0 0 2 2 2 1 Nuclear receptor coactivator Peptidase_M41 PF01434.13 AMD20475.1 - 4e-70 235.6 0.2 6.6e-70 234.9 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 AMD20475.1 - 2.5e-41 140.9 0.0 5.1e-41 139.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 AMD20475.1 - 1.9e-05 24.7 0.3 0.0001 22.3 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 AMD20475.1 - 2e-05 24.7 0.2 0.02 15.0 0.1 3.1 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.8 AMD20475.1 - 0.00049 18.9 0.0 0.00091 18.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_17 PF13207.1 AMD20475.1 - 0.00062 20.5 0.0 0.0018 19.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD20475.1 - 0.00097 18.8 1.3 0.0036 17.0 0.9 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 AMD20475.1 - 0.001 18.8 0.1 0.0046 16.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 AMD20475.1 - 0.0013 17.7 0.0 0.0034 16.4 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 AMD20475.1 - 0.002 17.5 1.1 0.059 12.7 0.2 2.5 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.12 AMD20475.1 - 0.0039 16.6 0.0 0.0078 15.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 AMD20475.1 - 0.006 16.4 0.0 0.12 12.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.9 AMD20475.1 - 0.022 14.7 0.0 0.096 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 AMD20475.1 - 0.022 15.0 0.0 0.063 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 AMD20475.1 - 0.022 13.8 0.0 0.049 12.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 AMD20475.1 - 0.025 14.4 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 AMD20475.1 - 0.042 12.9 0.1 0.094 11.8 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CHAT PF12770.2 AMD20475.1 - 0.082 12.0 0.0 0.27 10.3 0.0 1.8 1 0 0 1 1 1 0 CHAT domain AAA_28 PF13521.1 AMD20475.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Cyclin_N PF00134.18 AMD20476.1 - 5.5e-10 38.8 0.4 1.2e-09 37.7 0.2 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.14 AMD20476.1 - 0.00021 21.0 0.0 0.00038 20.1 0.0 1.5 1 0 0 1 1 1 1 Transcription factor TFIIB repeat DUF2320 PF10082.4 AMD20476.1 - 0.093 11.4 0.0 0.25 10.0 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2320) ATP-synt_ab PF00006.20 AMD20477.1 - 1.7e-70 236.8 0.0 3.2e-70 235.9 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 AMD20477.1 - 1.1e-26 93.5 0.9 2.8e-26 92.2 0.6 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 AMD20477.1 - 1e-16 60.8 2.6 2.9e-16 59.4 1.8 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 AMD20477.1 - 0.0047 16.7 0.8 0.012 15.5 0.5 1.7 1 0 0 1 1 1 1 HAS barrel domain AAA_25 PF13481.1 AMD20477.1 - 0.0083 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain HTH_IclR PF09339.5 AMD20477.1 - 0.086 12.4 0.4 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain Glyco_hydro_65m PF03632.10 AMD20478.1 - 6.5e-93 311.3 2.5 3.5e-92 308.9 1.7 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 AMD20478.1 - 7.2e-27 94.3 0.1 1.8e-26 93.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.10 AMD20478.1 - 4.2e-08 33.1 0.0 1.3e-07 31.5 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain TB2_DP1_HVA22 PF03134.14 AMD20479.1 - 3.2e-32 110.1 5.1 4.3e-32 109.7 3.5 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Adaptin_N PF01602.15 AMD20480.1 - 2.9e-105 352.5 14.3 3.7e-105 352.2 9.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 AMD20480.1 - 6.9e-09 36.0 0.1 1.9e-08 34.6 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.1 AMD20480.1 - 3e-05 24.2 0.6 0.98 9.7 0.0 4.5 3 1 1 4 4 4 1 HEAT repeats DNA_pol_B_3 PF08408.5 AMD20480.1 - 0.0038 17.1 0.4 0.01 15.6 0.3 1.7 1 0 0 1 1 1 1 DNA polymerase family B viral insert HEAT_EZ PF13513.1 AMD20480.1 - 0.02 15.3 2.3 17 6.0 0.1 4.3 3 1 1 4 4 4 0 HEAT-like repeat HEAT PF02985.17 AMD20480.1 - 0.073 13.1 0.6 9.4 6.6 0.1 3.8 3 0 0 3 3 3 0 HEAT repeat Arm PF00514.18 AMD20480.1 - 7.5 6.5 8.1 3.7 7.5 0.1 4.4 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Arrestin_C PF02752.17 AMD20481.1 - 6.2e-18 65.2 0.0 1.6e-17 63.8 0.0 1.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Got1 PF04178.7 AMD20482.1 - 7e-31 106.7 16.9 9.4e-31 106.3 11.7 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family HLH PF00010.21 AMD20483.1 - 2.4e-12 46.3 0.6 5.5e-12 45.2 0.4 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Cyclin_N PF00134.18 AMD20484.1 - 6.9e-41 138.7 0.1 1.4e-40 137.7 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 AMD20484.1 - 1.1e-28 99.5 0.1 3e-28 98.0 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain Sas10 PF09368.5 AMD20485.1 - 4.7e-30 103.5 11.4 4.7e-30 103.5 7.9 2.0 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 AMD20485.1 - 2.4e-12 46.8 1.7 1.3e-11 44.5 0.0 2.8 1 1 1 2 2 2 1 Sas10/Utp3/C1D family RNA_pol_Rpc4 PF05132.9 AMD20486.1 - 4.2e-30 104.4 0.3 4.2e-30 104.4 0.2 3.4 4 0 0 4 4 4 1 RNA polymerase III RPC4 TraC PF07820.7 AMD20486.1 - 0.043 14.0 0.2 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 TraC-like protein zf-C4H2 PF10146.4 AMD20486.1 - 0.31 11.0 14.4 1.6 8.7 10.0 2.0 1 1 0 1 1 1 0 Zinc finger-containing protein APG9 PF04109.11 AMD20487.1 - 3.3e-158 526.4 6.9 4.4e-158 526.0 4.8 1.2 1 0 0 1 1 1 1 Autophagy protein Apg9 Nop14 PF04147.7 AMD20488.1 - 6.7e-226 752.1 59.2 1.8e-130 436.4 9.5 2.0 1 1 1 2 2 2 2 Nop14-like family PCI PF01399.22 AMD20489.1 - 1.1e-21 77.1 3.1 1.4e-20 73.5 0.0 2.8 2 1 0 2 2 2 1 PCI domain TPR_20 PF14561.1 AMD20489.1 - 0.0072 16.4 1.1 0.061 13.4 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat OspE PF02471.12 AMD20489.1 - 0.084 12.7 1.9 0.32 10.9 0.1 2.4 2 0 0 2 2 2 0 Borrelia outer surface protein E AHS1 PF02682.11 AMD20489.1 - 0.14 11.5 0.3 0.36 10.2 0.2 1.7 1 0 0 1 1 1 0 Allophanate hydrolase subunit 1 NPV_P10 PF05531.7 AMD20489.1 - 0.99 9.6 6.8 0.19 12.0 0.2 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4259 PF14078.1 AMD20489.1 - 1.8 9.0 6.8 0.6 10.6 0.1 3.2 3 2 1 4 4 4 0 Domain of unknown function (DUF4259) DUF2216 PF10226.4 AMD20490.1 - 0.002 17.6 2.2 0.002 17.6 1.5 2.0 2 0 0 2 2 2 1 Uncharacterized conserved proteins (DUF2216) DUF1465 PF07323.7 AMD20490.1 - 0.023 14.2 1.1 0.047 13.2 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) bZIP_1 PF00170.16 AMD20490.1 - 0.035 14.0 1.4 0.035 14.0 1.0 3.3 2 2 1 3 3 3 0 bZIP transcription factor TCTP PF00838.12 AMD20490.1 - 0.04 13.9 2.1 0.048 13.6 0.0 1.9 2 0 0 2 2 2 0 Translationally controlled tumour protein DUF972 PF06156.8 AMD20490.1 - 0.37 11.1 12.0 0.096 13.0 3.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF972) FUN14 PF04930.10 AMD20490.1 - 0.47 10.7 1.8 0.74 10.1 0.2 2.0 2 1 0 2 2 2 0 FUN14 family DUF2935 PF11155.3 AMD20490.1 - 0.57 10.2 4.4 11 6.0 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Spectrin PF00435.16 AMD20490.1 - 0.59 10.4 13.2 0.093 13.0 4.2 2.3 2 1 0 2 2 2 0 Spectrin repeat DUF2013 PF09431.5 AMD20491.1 - 1.1e-39 135.3 12.7 1.1e-39 135.3 8.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Ovate PF04844.8 AMD20491.1 - 0.038 13.7 1.7 0.14 11.9 0.0 2.6 2 0 0 2 2 2 0 Transcriptional repressor, ovate Tubulin PF00091.20 AMD20492.1 - 5.4e-70 235.5 0.0 7.9e-70 235.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 AMD20492.1 - 7.2e-32 110.0 0.1 1.9e-31 108.6 0.0 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 AMD20492.1 - 6.9e-07 29.3 0.0 2.3e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Coatomer_WDAD PF04053.9 AMD20493.1 - 6.6e-134 447.0 4.6 1e-133 446.4 3.2 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 AMD20493.1 - 4.3e-66 223.1 0.0 6.2e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 AMD20493.1 - 1.9e-54 179.6 16.1 9.2e-10 38.0 0.0 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat eIF2A PF08662.6 AMD20493.1 - 0.00019 21.2 0.9 0.64 9.6 0.0 3.7 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 AMD20493.1 - 0.00021 19.5 3.8 0.47 8.5 0.0 3.7 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Herpes_MCP PF03122.9 AMD20493.1 - 0.067 10.5 0.0 0.22 8.7 0.0 1.6 2 0 0 2 2 2 0 Herpes virus major capsid protein Rapsyn_N PF10579.4 AMD20493.1 - 0.097 12.4 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region TPR_2 PF07719.12 AMD20493.1 - 9.8 6.3 7.5 3.3 7.8 0.0 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat Glyco_hydro_16 PF00722.16 AMD20494.1 - 5.3e-46 156.2 0.3 7.7e-46 155.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 WAP PF00095.16 AMD20494.1 - 0.0053 16.7 3.2 0.009 15.9 2.3 1.3 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' DUF2243 PF10002.4 AMD20494.1 - 0.053 13.3 0.8 0.097 12.4 0.3 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2243) Chitin_bind_1 PF00187.14 AMD20494.1 - 0.17 11.8 11.3 0.28 11.1 7.8 1.3 1 0 0 1 1 1 0 Chitin recognition protein ApbA_C PF08546.6 AMD20495.1 - 6.8e-27 93.9 0.0 1.1e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 AMD20495.1 - 2.1e-20 72.6 0.0 4.3e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DAO PF01266.19 AMD20495.1 - 0.0052 15.7 0.0 0.0081 15.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF2092 PF09865.4 AMD20495.1 - 0.0089 15.1 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 Predicted periplasmic protein (DUF2092) Pyr_redox PF00070.22 AMD20495.1 - 0.014 15.7 0.0 0.044 14.1 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 AMD20495.1 - 0.033 14.2 0.1 0.071 13.2 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.16 AMD20495.1 - 0.042 13.6 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 ThiF family NAD_binding_8 PF13450.1 AMD20495.1 - 0.054 13.5 0.2 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.1 AMD20495.1 - 0.057 13.6 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Pyr_redox_2 PF07992.9 AMD20495.1 - 0.12 12.2 0.6 0.28 11.0 0.3 1.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ferric_reduct PF01794.14 AMD20496.1 - 1.8e-21 76.5 6.1 6e-21 74.8 4.2 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 AMD20496.1 - 2.4e-21 75.5 0.0 5.2e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 AMD20496.1 - 2.4e-09 37.3 0.0 4.3e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF4405 PF14358.1 AMD20496.1 - 0.014 15.5 6.9 1.4 9.0 1.7 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) DUF373 PF04123.8 AMD20496.1 - 0.087 11.8 1.9 0.15 11.0 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) D123 PF07065.9 AMD20497.1 - 2.2e-109 365.1 1.9 2.9e-109 364.7 1.3 1.2 1 0 0 1 1 1 1 D123 Cpn60_TCP1 PF00118.19 AMD20498.1 - 4.3e-136 454.3 13.3 4.9e-136 454.1 9.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CDP-OH_P_transf PF01066.16 AMD20499.1 - 8.4e-17 61.3 7.4 2.3e-16 59.9 5.1 1.9 1 1 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Mito_carr PF00153.22 AMD20500.1 - 7.5e-54 179.4 3.7 8.7e-20 70.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltrans PF00432.16 AMD20501.1 - 8.5e-33 111.5 6.0 2.7e-07 30.0 0.0 5.2 5 1 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 AMD20501.1 - 2.5e-16 60.0 0.0 7.9e-05 23.0 0.0 3.4 2 1 1 3 3 3 3 Prenyltransferase-like Glyco_hydro_38 PF01074.17 AMD20502.1 - 1.7e-81 273.5 0.3 2.6e-81 272.8 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 AMD20502.1 - 3.7e-66 223.8 1.5 5.1e-66 223.3 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 AMD20502.1 - 9.1e-25 86.6 0.0 2.4e-24 85.3 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase, middle domain HMG_CoA_synt_C PF08540.5 AMD20502.1 - 0.011 15.2 1.1 0.8 9.1 0.1 2.4 2 0 0 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal Inhibitor_I9 PF05922.11 AMD20503.1 - 0.00029 21.3 0.1 0.00085 19.8 0.1 1.8 1 1 0 1 1 1 1 Peptidase inhibitor I9 Frataxin_Cyay PF01491.11 AMD20504.1 - 3.2e-32 110.5 0.0 4.2e-32 110.1 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain HCMV_UL139 PF12507.3 AMD20505.1 - 0.1 12.7 1.5 0.14 12.3 1.0 1.1 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein UCH PF00443.24 AMD20506.1 - 6.7e-48 163.1 0.0 8.9e-48 162.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD20506.1 - 9.2e-11 41.7 3.9 3.4e-05 23.4 0.3 3.3 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase RRM_1 PF00076.17 AMD20507.1 - 9.2e-52 172.5 1.8 1.3e-18 66.4 0.2 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD20507.1 - 1.5e-27 95.3 0.3 1.7e-10 40.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20507.1 - 1.7e-24 85.4 2.4 2.5e-08 33.6 0.1 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cas_Cas2CT1978 PF09707.5 AMD20507.1 - 0.061 13.2 0.0 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) DUF4152 PF13680.1 AMD20507.1 - 0.13 11.2 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4152) DFP PF04127.10 AMD20508.1 - 2.4e-17 63.1 0.0 1.1e-09 38.1 0.0 2.6 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Bac_surface_Ag PF01103.18 AMD20509.1 - 1.2e-43 149.8 7.1 1.6e-43 149.4 4.9 1.2 1 0 0 1 1 1 1 Surface antigen zf-C2H2 PF00096.21 AMD20510.1 - 8.9e-14 50.9 12.6 1.6e-06 28.1 1.6 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD20510.1 - 2.2e-13 49.7 8.0 4.3e-07 29.9 0.3 3.9 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 AMD20510.1 - 7.3e-11 41.6 9.2 0.00048 20.2 0.7 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.2 AMD20510.1 - 3.8e-07 30.0 4.3 2.9e-05 24.1 0.3 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD20510.1 - 2.1e-06 27.7 7.7 0.00058 19.9 0.4 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding Zn_ribbon_recom PF13408.1 AMD20510.1 - 0.0049 17.0 2.3 0.0049 17.0 1.6 2.2 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain FYVE PF01363.16 AMD20510.1 - 0.14 12.0 4.6 0.28 11.1 3.2 1.5 1 0 0 1 1 1 0 FYVE zinc finger C1_2 PF03107.11 AMD20510.1 - 0.25 11.4 1.1 21 5.3 0.0 2.6 2 0 0 2 2 2 0 C1 domain zf-C2H2_6 PF13912.1 AMD20510.1 - 0.27 11.1 6.7 16 5.6 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.10 AMD20510.1 - 0.27 11.0 6.2 1.4 8.7 0.3 3.1 2 1 1 3 3 3 0 BED zinc finger C1_4 PF07975.7 AMD20510.1 - 1.9 8.5 4.3 16 5.6 3.0 2.3 1 1 1 2 2 2 0 TFIIH C1-like domain zf-H2C2_5 PF13909.1 AMD20510.1 - 2.4 8.5 5.2 1 9.7 0.8 2.6 3 0 0 3 3 2 0 C2H2-type zinc-finger domain Sds3 PF08598.6 AMD20511.1 - 2.4e-59 200.3 6.2 3.2e-59 199.9 4.3 1.2 1 0 0 1 1 1 1 Sds3-like Histone PF00125.19 AMD20512.1 - 2.9e-14 52.9 0.2 3.5e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 AMD20512.1 - 5.5e-05 23.0 0.2 8e-05 22.5 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 AMD20512.1 - 6.6e-05 23.0 0.1 9.7e-05 22.4 0.1 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 AMD20512.1 - 8e-05 22.6 0.1 0.00015 21.7 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 AMD20512.1 - 0.003 16.8 0.0 0.0032 16.7 0.0 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 AMD20512.1 - 0.0046 16.6 0.0 0.0059 16.3 0.0 1.3 1 1 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.8 AMD20512.1 - 0.036 14.3 0.1 0.062 13.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.10 AMD20512.1 - 0.14 11.9 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.19 AMD20513.1 - 5.2e-30 103.3 0.7 8.5e-30 102.7 0.5 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 AMD20513.1 - 9.4e-07 28.9 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 AMD20513.1 - 0.002 18.1 1.0 0.0025 17.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 AMD20513.1 - 0.058 13.1 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated DUF2416 PF10315.4 AMD20514.1 - 1.5e-37 128.0 0.8 1.8e-37 127.8 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2416) Y_phosphatase2 PF03162.8 AMD20515.1 - 2.1e-63 212.5 0.1 2.8e-63 212.1 0.1 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 AMD20515.1 - 6.9e-07 29.6 0.0 1.2e-06 28.9 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 AMD20515.1 - 0.0025 17.3 0.0 0.0045 16.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 AMD20515.1 - 0.0035 16.6 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Aa_trans PF01490.13 AMD20516.1 - 1.9e-99 332.9 12.9 2.2e-99 332.7 8.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PepSY_TM_2 PF13703.1 AMD20516.1 - 0.097 12.8 0.4 0.097 12.8 0.3 3.6 6 0 0 6 6 6 0 PepSY-associated TM helix TRAM_LAG1_CLN8 PF03798.11 AMD20517.1 - 3.3e-37 127.9 23.7 3.3e-37 127.9 16.4 1.5 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.6 AMD20517.1 - 7e-16 57.4 0.8 7e-16 57.4 0.6 2.5 2 0 0 2 2 2 1 TRAM1-like protein Cyclin_N PF00134.18 AMD20518.1 - 1.1e-17 63.7 0.6 1.3e-16 60.3 0.2 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 AMD20518.1 - 0.00012 21.9 0.5 0.024 14.5 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain ICE2 PF08426.5 AMD20519.1 - 2.2e-152 507.4 32.5 2.6e-152 507.2 22.5 1.0 1 0 0 1 1 1 1 ICE2 DUF1253 PF06862.7 AMD20520.1 - 1.4e-156 521.3 11.7 1.4e-156 521.3 8.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1253) DEAD PF00270.24 AMD20520.1 - 7.4e-05 22.2 2.8 0.00094 18.7 1.1 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase DUF1242 PF06842.7 AMD20521.1 - 1.7e-14 52.9 0.2 2.3e-14 52.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) MRP-S25 PF13741.1 AMD20522.1 - 6e-85 284.3 1.1 6.9e-85 284.1 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.4 AMD20522.1 - 0.0034 17.2 3.7 0.044 13.6 0.1 2.6 2 1 0 3 3 3 2 Mitochondrial ribosomal protein S23 R3H PF01424.17 AMD20523.1 - 1.1e-12 47.3 0.1 2.3e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.12 AMD20523.1 - 1.9e-05 24.4 32.6 4.7e-05 23.2 8.7 12.1 11 2 0 11 11 11 5 NF-X1 type zinc finger Iso_dh PF00180.15 AMD20524.1 - 5.1e-103 344.6 0.1 6e-103 344.4 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase TrmE_N PF10396.4 AMD20524.1 - 0.061 13.2 0.1 0.23 11.4 0.0 1.9 1 1 0 1 1 1 0 GTP-binding protein TrmE N-terminus PdxA PF04166.7 AMD20524.1 - 0.095 11.8 0.0 0.2 10.8 0.0 1.5 2 0 0 2 2 2 0 Pyridoxal phosphate biosynthetic protein PdxA DUF1447 PF07288.6 AMD20524.1 - 0.12 12.2 0.1 2.3 8.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1447) Nol1_Nop2_Fmu PF01189.12 AMD20525.1 - 2e-16 60.2 0.0 2.1e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 AMD20525.1 - 0.00012 22.0 0.0 0.00068 19.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD20525.1 - 0.033 13.7 0.0 0.16 11.5 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain Hist_deacetyl PF00850.14 AMD20526.1 - 3.3e-96 322.2 0.0 4.7e-96 321.7 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.4 AMD20526.1 - 2.5e-51 173.6 0.1 3.6e-51 173.1 0.1 1.2 1 0 0 1 1 1 1 Arb2 domain Pkinase PF00069.20 AMD20527.1 - 4.3e-38 130.9 0.0 6.6e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20527.1 - 2.4e-27 95.6 0.0 3.2e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20527.1 - 5.9e-06 25.4 0.0 1.1e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD20527.1 - 0.011 15.4 0.0 0.74 9.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Dabb PF07876.7 AMD20527.1 - 0.036 14.5 0.0 0.09 13.2 0.0 1.6 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain WD40 PF00400.27 AMD20528.1 - 1.6e-12 46.7 0.0 1e-05 25.2 0.1 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat Myb_DNA-binding PF00249.26 AMD20529.1 - 1.2e-07 31.6 0.0 2.7e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD20529.1 - 0.14 12.3 0.2 0.14 12.3 0.1 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain CotJB PF12652.2 AMD20529.1 - 2.5 8.2 5.7 0.73 9.9 0.3 2.6 2 0 0 2 2 2 0 CotJB protein PIG-H PF10181.4 AMD20530.1 - 1.7e-22 78.8 1.6 2.7e-22 78.1 1.1 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DUF805 PF05656.9 AMD20530.1 - 2.2 8.1 5.4 1.4 8.7 2.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF805) DUF2431 PF10354.4 AMD20531.1 - 3.9e-52 176.5 0.0 6.4e-52 175.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Tantalus PF15386.1 AMD20531.1 - 0.13 12.0 3.1 0.47 10.2 2.2 1.9 1 0 0 1 1 1 0 Drosophila Tantalus-like CLTH PF10607.4 AMD20532.1 - 1.6e-28 99.2 0.4 1.6e-28 99.2 0.3 2.3 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain U-box PF04564.10 AMD20532.1 - 0.028 14.3 0.0 0.083 12.8 0.0 1.8 1 0 0 1 1 1 0 U-box domain Iso_dh PF00180.15 AMD20533.1 - 2.1e-82 276.8 0.0 2.6e-82 276.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Complex1_LYR_2 PF13233.1 AMD20534.1 - 2.9e-17 63.0 8.4 6.4e-17 61.9 5.9 1.5 1 1 0 1 1 1 1 Complex1_LYR-like SurA_N_2 PF13623.1 AMD20534.1 - 0.051 13.5 2.3 0.8 9.6 0.3 2.1 2 0 0 2 2 2 0 SurA N-terminal domain Speriolin_N PF15058.1 AMD20534.1 - 0.11 12.4 1.2 0.5 10.2 0.9 1.9 1 1 0 1 1 1 0 Speriolin N terminus Microtub_assoc PF07989.6 AMD20534.1 - 0.62 9.9 5.7 0.95 9.3 2.5 2.3 2 1 0 2 2 2 0 Microtubule associated MRP-L28 PF09812.4 AMD20534.1 - 0.87 9.4 8.1 0.2 11.4 0.2 2.1 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L28 Glyco_hydro_15 PF00723.16 AMD20535.1 - 5.4e-52 176.8 0.0 8.9e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 DUF247 PF03140.10 AMD20535.1 - 0.035 13.1 0.4 0.059 12.3 0.3 1.3 1 0 0 1 1 1 0 Plant protein of unknown function FrpC PF06901.7 AMD20535.1 - 0.13 11.8 0.1 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 RTX iron-regulated protein FrpC Pro_CA PF00484.14 AMD20536.1 - 3.8e-39 134.1 0.0 4.6e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase ODC_AZ PF02100.12 AMD20536.1 - 0.067 12.6 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Ornithine decarboxylase antizyme Pkinase PF00069.20 AMD20538.1 - 1.3e-65 221.1 0.2 1.6e-65 220.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20538.1 - 2.5e-35 121.8 0.0 3.5e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 AMD20538.1 - 3.2e-17 62.3 0.0 8.5e-17 61.0 0.0 1.8 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.1 AMD20538.1 - 4.9e-06 25.7 0.0 7.9e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD20538.1 - 0.00078 18.5 0.0 0.0014 17.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD20538.1 - 0.089 12.5 0.0 0.3 10.7 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1132 PF06575.7 AMD20538.1 - 0.34 11.2 3.2 15 5.9 0.2 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1132) FAM91_C PF14648.1 AMD20539.1 - 0.014 14.2 0.1 0.12 11.1 0.0 2.0 1 1 1 2 2 2 0 FAM91 C-terminus SOG2 PF10428.4 AMD20540.1 - 7.2e-124 413.8 16.5 7.2e-124 413.8 11.4 2.2 1 1 1 2 2 2 1 RAM signalling pathway protein LRR_4 PF12799.2 AMD20540.1 - 1e-14 53.7 15.3 5.1e-08 32.3 0.7 4.0 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 AMD20540.1 - 7.8e-14 51.1 12.2 4.7e-11 42.2 2.0 3.8 3 1 1 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 AMD20540.1 - 9.8e-08 31.0 9.3 0.02 14.8 0.0 5.8 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 AMD20540.1 - 7.3e-05 22.3 5.8 0.073 13.3 0.0 5.6 5 0 0 5 5 5 1 Leucine rich repeat LRR_6 PF13516.1 AMD20540.1 - 0.34 11.1 11.1 1.6 9.0 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeat Cyto_heme_lyase PF01265.12 AMD20541.1 - 6.2e-68 229.1 0.0 7e-68 229.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase Med12 PF09497.5 AMD20542.1 - 0.092 12.7 0.0 0.31 11.0 0.0 1.9 1 0 0 1 1 1 0 Transcription mediator complex subunit Med12 Cyclin_N PF00134.18 AMD20543.1 - 1.6e-30 105.3 0.6 2.9e-30 104.4 0.4 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cupin_8 PF13621.1 AMD20544.1 - 6.6e-47 160.1 0.0 7e-45 153.4 0.0 2.1 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 AMD20544.1 - 0.03 14.5 0.1 0.068 13.4 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_4 PF08007.7 AMD20544.1 - 0.038 13.2 0.3 7 5.7 0.0 2.9 3 1 0 3 3 3 0 Cupin superfamily protein ETF_QO PF05187.8 AMD20546.1 - 1.4e-38 131.2 0.0 2.3e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 AMD20546.1 - 1.1e-11 44.2 2.5 4.3e-05 22.5 0.7 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AMD20546.1 - 2.6e-08 33.1 1.2 0.00087 18.2 0.5 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 AMD20546.1 - 8.2e-07 28.9 0.1 2.4e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 AMD20546.1 - 2.4e-05 24.5 0.1 0.00022 21.3 0.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 AMD20546.1 - 3.4e-05 23.0 0.0 0.006 15.7 0.1 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 AMD20546.1 - 8.1e-05 22.5 0.0 0.0002 21.3 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 AMD20546.1 - 8.7e-05 21.1 0.5 0.0013 17.3 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.14 AMD20546.1 - 0.00011 21.3 0.3 0.00033 19.8 0.2 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 AMD20546.1 - 0.00013 22.2 0.7 0.11 12.9 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 AMD20546.1 - 0.0008 18.5 0.0 0.0014 17.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 AMD20546.1 - 0.0027 17.5 0.2 0.0061 16.3 0.2 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Fer4_7 PF12838.2 AMD20546.1 - 0.0085 16.4 0.6 0.025 14.9 0.4 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Lycopene_cycl PF05834.7 AMD20546.1 - 0.0091 14.9 0.2 0.013 14.4 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.16 AMD20546.1 - 0.017 14.6 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.9 AMD20546.1 - 0.017 13.7 0.6 0.5 8.9 0.2 2.2 2 0 0 2 2 2 0 Tryptophan halogenase RhoGEF PF00621.15 AMD20547.1 - 3.3e-38 131.3 5.4 1.2e-37 129.5 3.7 2.0 1 0 0 1 1 1 1 RhoGEF domain CDC24 PF06395.6 AMD20547.1 - 1.9e-35 120.7 1.7 3.4e-35 119.9 0.4 2.1 2 0 0 2 2 2 1 CDC24 Calponin PH_10 PF15411.1 AMD20547.1 - 2.6e-22 79.2 5.2 2.9e-22 79.0 0.5 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain PB1 PF00564.19 AMD20547.1 - 3.4e-06 26.6 1.3 8e-06 25.4 0.3 2.1 2 0 0 2 2 2 1 PB1 domain COPIIcoated_ERV PF07970.7 AMD20548.1 - 6e-72 241.8 0.0 7.9e-72 241.4 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 AMD20548.1 - 1.2e-27 95.7 0.4 2.6e-27 94.6 0.2 1.6 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PX PF00787.19 AMD20549.1 - 3.6e-21 75.0 0.1 4.7e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 PX domain CBFD_NFYB_HMF PF00808.18 AMD20550.1 - 1.1e-22 79.8 1.6 1.1e-22 79.8 1.1 1.4 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 AMD20550.1 - 2.4e-16 59.5 0.2 3.2e-16 59.1 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 AMD20550.1 - 0.0016 18.2 0.2 0.0024 17.6 0.1 1.3 1 0 0 1 1 1 1 CENP-S associating Centromere protein X DUF2248 PF10005.4 AMD20550.1 - 0.041 12.8 0.1 0.077 11.9 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2248) TAFII28 PF04719.9 AMD20550.1 - 0.05 13.3 0.2 0.066 13.0 0.2 1.2 1 0 0 1 1 1 0 hTAFII28-like protein conserved region DUF3791 PF12668.2 AMD20550.1 - 0.065 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) TAF PF02969.12 AMD20550.1 - 0.079 12.9 0.3 0.14 12.1 0.1 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) DUF3453 PF11935.3 AMD20551.1 - 7.1e-57 192.5 0.1 1.1e-56 191.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) K_channel_TID PF07941.6 AMD20551.1 - 0.0065 16.6 0.2 0.0065 16.6 0.2 3.3 2 1 1 3 3 3 1 Potassium channel Kv1.4 tandem inactivation domain MSP1_C PF07462.6 AMD20551.1 - 1.1 7.6 4.6 2.1 6.6 3.2 1.4 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus SAM_2 PF07647.12 AMD20552.1 - 1.9e-06 27.6 0.0 3.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 AMD20552.1 - 2.3e-06 27.6 1.1 4.1e-06 26.8 0.1 1.9 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) PDEase_I PF00233.14 AMD20553.1 - 2.3e-41 142.1 0.2 4.4e-40 137.9 0.1 2.3 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF2775 PF10950.3 AMD20553.1 - 0.09 13.0 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2775) GCV_H PF01597.14 AMD20554.1 - 2.1e-43 146.8 0.1 2.5e-43 146.6 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein BolA PF01722.13 AMD20555.1 - 6.4e-25 86.9 1.5 8.5e-25 86.5 1.0 1.1 1 0 0 1 1 1 1 BolA-like protein BolA PF01722.13 AMD20556.1 - 2.2e-17 62.7 0.0 3e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein eIF2A PF08662.6 AMD20557.1 - 8.2e-27 94.1 2.0 4e-23 82.1 1.3 4.0 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.17 AMD20557.1 - 4.5e-10 39.0 0.1 1.4e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20557.1 - 2.6e-07 30.3 0.0 1.1e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD20557.1 - 4.6e-06 26.5 0.0 1.3e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Mto2_bdg PF12808.2 AMD20558.1 - 0.0036 17.3 6.3 0.0036 17.3 4.3 4.9 5 0 0 5 5 5 1 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF948 PF06103.6 AMD20558.1 - 0.29 11.0 20.3 0.11 12.3 1.1 4.5 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF641 PF04859.7 AMD20558.1 - 7.1 6.4 37.3 0.21 11.3 0.5 6.0 3 2 2 6 6 6 0 Plant protein of unknown function (DUF641) PEP-utilisers_N PF05524.8 AMD20558.1 - 7.5 6.3 17.1 0.14 11.9 0.3 4.4 3 2 0 3 3 3 0 PEP-utilising enzyme, N-terminal Proteasome PF00227.21 AMD20559.1 - 8.6e-52 175.1 0.1 3.1e-51 173.3 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.4 AMD20559.1 - 7.5e-12 44.3 0.9 9.4e-12 44.0 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Miro PF08477.8 AMD20560.1 - 4.4e-42 143.3 0.0 3.9e-21 75.7 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein EF_assoc_1 PF08355.7 AMD20560.1 - 3e-29 100.1 0.8 5.7e-29 99.2 0.5 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.7 AMD20560.1 - 1.8e-27 94.8 0.0 8.5e-27 92.7 0.0 2.1 2 0 0 2 2 2 1 EF hand associated Ras PF00071.17 AMD20560.1 - 4.6e-26 91.1 0.0 2.7e-13 49.6 0.0 2.5 2 0 0 2 2 2 2 Ras family EF-hand_1 PF00036.27 AMD20560.1 - 3.2e-11 41.6 4.2 0.00026 20.0 0.2 3.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 AMD20560.1 - 7e-10 37.9 5.0 0.00044 19.8 0.1 3.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 AMD20560.1 - 2.7e-09 37.0 1.8 0.0079 16.3 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 AMD20560.1 - 2.4e-07 29.8 1.5 0.0018 17.5 0.2 2.7 2 0 0 2 2 2 2 EF hand Dynamin_N PF00350.18 AMD20560.1 - 8.1e-07 29.0 0.0 0.017 14.9 0.0 2.5 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.18 AMD20560.1 - 6e-06 26.1 0.0 0.021 14.7 0.0 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.1 AMD20560.1 - 2.3e-05 24.4 0.0 0.13 12.2 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain GTP_EFTU PF00009.22 AMD20560.1 - 3e-05 23.5 0.0 0.48 9.8 0.0 3.4 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 AMD20560.1 - 0.0004 19.8 0.0 0.23 11.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.1 AMD20560.1 - 0.00086 19.4 0.0 0.34 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 AMD20560.1 - 0.0011 19.2 0.0 0.063 13.5 0.0 2.4 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.11 AMD20560.1 - 0.0018 17.4 0.0 0.018 14.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 AMD20560.1 - 0.0096 15.9 0.1 0.29 11.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 AMD20560.1 - 0.018 14.4 0.0 1 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain RNA_helicase PF00910.17 AMD20560.1 - 0.033 14.3 0.0 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Septin PF00735.13 AMD20560.1 - 0.04 12.9 0.0 1 8.3 0.0 2.4 3 0 0 3 3 3 0 Septin AAA_24 PF13479.1 AMD20560.1 - 0.05 13.1 0.0 1.6 8.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_32 PF13654.1 AMD20560.1 - 0.052 12.1 0.0 0.23 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 AMD20560.1 - 0.079 12.6 0.0 4.9 6.8 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.1 AMD20560.1 - 0.093 13.0 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain EF-hand_10 PF14788.1 AMD20560.1 - 0.12 12.0 1.1 2.7 7.7 0.0 2.7 3 0 0 3 3 2 0 EF hand SPARC_Ca_bdg PF10591.4 AMD20560.1 - 0.14 12.2 2.9 36 4.4 0.1 3.6 4 0 0 4 4 3 0 Secreted protein acidic and rich in cysteine Ca binding region MCM PF00493.18 AMD20560.1 - 0.22 10.3 0.1 2.9 6.6 0.0 2.3 2 0 0 2 2 2 0 MCM2/3/5 family EF-hand_8 PF13833.1 AMD20560.1 - 0.44 10.2 3.1 9.9 5.8 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain pair Zn_clus PF00172.13 AMD20561.1 - 5.2e-11 42.2 13.6 1.2e-10 41.1 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 AMD20562.1 - 2.5e-08 33.6 10.4 5e-08 32.7 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.13 AMD20563.1 - 1.8e-10 40.5 6.6 3.8e-10 39.5 4.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KxDL PF10241.4 AMD20563.1 - 0.061 13.2 0.4 0.85 9.5 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein TRP PF06011.7 AMD20564.1 - 7.2e-154 512.5 29.3 1e-153 512.0 20.3 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 AMD20564.1 - 8.4e-37 126.3 2.8 1.4e-36 125.5 1.9 1.4 1 0 0 1 1 1 1 ML-like domain Neur_chan_memb PF02932.11 AMD20564.1 - 0.081 12.7 0.0 0.081 12.7 0.0 2.5 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region AMP-binding PF00501.23 AMD20565.1 - 1.9e-92 309.8 0.1 2.3e-92 309.5 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 AMD20565.1 - 8.4e-18 65.0 0.1 3e-17 63.3 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain MHC_II_beta PF00969.14 AMD20565.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain CH PF00307.26 AMD20566.1 - 3.7e-09 36.5 0.0 5.2e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Peroxin-22 PF12827.2 AMD20567.1 - 5.7e-19 67.9 0.0 8.1e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family Rad1 PF02144.11 AMD20568.1 - 1.1e-60 204.7 1.6 1.1e-60 204.7 1.1 1.5 2 0 0 2 2 2 1 Repair protein Rad1/Rec1/Rad17 Ribosomal_L7Ae PF01248.21 AMD20569.1 - 6.4e-20 70.4 0.1 9e-20 69.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1269 PF06897.7 AMD20569.1 - 0.0089 16.0 0.2 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1269) NTP_transf_3 PF12804.2 AMD20569.1 - 0.021 14.9 0.2 0.025 14.6 0.1 1.1 1 0 0 1 1 1 0 MobA-like NTP transferase domain GDI PF00996.13 AMD20570.1 - 3.7e-58 196.8 0.0 4.7e-58 196.5 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor DUF1749 PF08538.5 AMD20570.1 - 0.062 12.1 0.3 0.12 11.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Kelch_4 PF13418.1 AMD20571.1 - 3.7e-12 45.8 3.2 1.9e-05 24.3 0.1 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.1 AMD20571.1 - 5.6e-08 32.7 0.0 0.0052 16.9 0.0 4.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.1 AMD20571.1 - 1.6e-07 31.2 4.2 0.0014 18.7 0.1 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.10 AMD20571.1 - 2.1e-05 24.0 1.4 0.091 12.5 0.3 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 AMD20571.1 - 0.00015 21.2 0.3 0.54 9.8 0.0 3.3 4 0 0 4 4 4 2 Kelch motif InvH PF04741.7 AMD20571.1 - 0.0053 16.6 0.1 0.019 14.8 0.0 2.0 1 0 0 1 1 1 1 InvH outer membrane lipoprotein LRR_4 PF12799.2 AMD20573.1 - 1.5e-12 46.8 47.1 2.6e-06 26.8 0.5 7.9 4 4 3 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 AMD20573.1 - 2.3e-10 40.0 39.8 6.1e-07 29.0 4.3 6.8 4 2 3 7 7 7 3 Leucine rich repeat LRR_6 PF13516.1 AMD20573.1 - 0.049 13.7 36.0 0.26 11.4 0.8 8.9 8 2 2 10 10 10 0 Leucine Rich repeat LRR_1 PF00560.28 AMD20573.1 - 0.13 12.4 42.4 1.2 9.4 0.0 10.4 10 2 1 11 11 11 0 Leucine Rich Repeat FNIP PF05725.7 AMD20573.1 - 2.8 7.9 11.5 11 6.0 1.3 4.0 4 0 0 4 4 4 0 FNIP Repeat Alb1 PF09135.6 AMD20575.1 - 9.6e-26 90.5 12.2 9.6e-26 90.5 8.5 1.8 1 1 1 2 2 2 1 Alb1 BRCT PF00533.21 AMD20575.1 - 0.085 13.0 0.1 0.2 11.8 0.1 1.8 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain PKI PF02827.11 AMD20575.1 - 8.5 6.5 8.3 2.5 8.2 1.2 2.5 2 1 0 2 2 2 0 cAMP-dependent protein kinase inhibitor SNO PF01174.14 AMD20576.1 - 5.9e-69 231.4 0.0 6.8e-69 231.2 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 AMD20576.1 - 7.6e-09 35.3 0.0 1.4e-08 34.5 0.0 1.4 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 AMD20576.1 - 2.8e-06 26.8 0.0 3.6e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I DUF4066 PF13278.1 AMD20576.1 - 0.025 13.8 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative amidotransferase UPF0180 PF03698.8 AMD20576.1 - 0.069 12.9 0.0 0.38 10.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) DUF4154 PF13689.1 AMD20576.1 - 0.13 11.9 0.0 0.31 10.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4154) SOR_SNZ PF01680.12 AMD20577.1 - 1.6e-104 348.0 4.7 2.2e-104 347.5 3.2 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 AMD20577.1 - 4.2e-09 35.8 1.7 3.5e-07 29.5 0.0 2.6 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG IGPS PF00218.16 AMD20577.1 - 0.0015 17.6 0.0 0.0048 15.9 0.0 1.8 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase His_biosynth PF00977.16 AMD20577.1 - 0.0023 17.2 0.3 0.05 12.8 0.0 2.7 2 1 1 3 3 3 1 Histidine biosynthesis protein NMO PF03060.10 AMD20577.1 - 0.0061 15.7 0.6 0.021 14.0 0.0 2.0 2 1 0 2 2 2 1 Nitronate monooxygenase NanE PF04131.9 AMD20577.1 - 0.0068 15.4 0.4 0.061 12.2 0.0 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase TMP-TENI PF02581.12 AMD20577.1 - 0.021 13.9 0.2 0.2 10.7 0.0 2.3 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI RRM_1 PF00076.17 AMD20578.1 - 0.00013 21.5 0.0 0.019 14.5 0.0 2.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD20578.1 - 0.00026 20.9 0.0 0.0018 18.2 0.0 2.4 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20578.1 - 0.0028 17.4 0.1 0.031 14.1 0.1 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHD_3 PF13922.1 AMD20578.1 - 0.99 9.6 0.0 0.99 9.6 0.0 3.3 3 1 0 3 3 3 0 PHD domain of transcriptional enhancer, Asx NGP1NT PF08153.7 AMD20579.1 - 1.2e-48 164.3 0.1 2e-48 163.6 0.1 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 AMD20579.1 - 8.3e-20 70.8 0.0 3.9e-15 55.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD20579.1 - 2e-05 23.9 0.0 9e-05 21.7 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 AMD20579.1 - 0.00012 21.9 0.1 0.33 10.7 0.0 3.5 2 1 1 3 3 3 1 Dynamin family DUF258 PF03193.11 AMD20579.1 - 0.00069 18.8 0.0 0.0015 17.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Arf PF00025.16 AMD20579.1 - 0.0019 17.4 0.1 0.22 10.7 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD20579.1 - 0.0033 16.8 0.0 0.61 9.4 0.0 3.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SusD-like_3 PF14322.1 AMD20579.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Starch-binding associating with outer membrane CAF1 PF04857.15 AMD20580.1 - 3e-51 174.2 0.8 5.1e-51 173.5 0.5 1.3 1 0 0 1 1 1 1 CAF1 family ribonuclease NTF2 PF02136.15 AMD20581.1 - 1e-19 71.0 0.7 2.1e-19 70.0 0.1 1.9 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 AMD20581.1 - 0.001 18.6 0.0 0.0029 17.1 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD20581.1 - 0.0058 16.5 0.1 0.02 14.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20581.1 - 0.011 15.5 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Y_phosphatase2 PF03162.8 AMD20582.1 - 4e-34 117.3 2.3 3.4e-32 111.0 1.6 2.3 1 1 0 1 1 1 1 Tyrosine phosphatase family Saccharop_dh PF03435.13 AMD20583.1 - 2.2e-109 365.9 0.0 2.5e-109 365.7 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 AMD20583.1 - 6.4e-08 32.7 0.2 1.3e-07 31.7 0.2 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 AMD20583.1 - 2.8e-07 30.7 0.7 3.9e-07 30.2 0.1 1.5 2 0 0 2 2 2 1 NADH(P)-binding F420_oxidored PF03807.12 AMD20583.1 - 2.1e-06 28.0 0.2 9.9e-06 25.9 0.2 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 AMD20583.1 - 3.4e-06 27.0 0.9 6.2e-06 26.2 0.6 1.4 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.14 AMD20583.1 - 8.4e-05 21.3 0.1 0.00012 20.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 AMD20583.1 - 0.00062 19.2 0.1 0.00094 18.6 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2325 PF10087.4 AMD20583.1 - 0.002 17.9 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2325) Semialdhyde_dh PF01118.19 AMD20583.1 - 0.0025 18.1 0.2 0.0078 16.5 0.1 1.8 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.11 AMD20583.1 - 0.071 13.5 0.2 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Mso1_Sec1_bdg PF14475.1 AMD20584.1 - 3e-19 68.1 0.1 8.9e-19 66.6 0.0 1.8 1 0 0 1 1 1 1 Sec1-binding region of Mso1 DLIC PF05783.6 AMD20584.1 - 6.9 5.2 6.9 2.4 6.6 2.6 1.6 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) Not1 PF04054.10 AMD20585.1 - 2.9e-144 480.6 3.6 2.9e-144 480.6 2.5 3.8 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 AMD20585.1 - 1.8e-43 147.7 6.4 1.8e-43 147.7 4.5 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3819) Caldesmon PF02029.10 AMD20585.1 - 0.00021 19.8 11.5 0.00029 19.4 8.0 1.1 1 0 0 1 1 1 1 Caldesmon Hom_end_hint PF05203.11 AMD20585.1 - 0.012 15.3 6.7 0.027 14.2 4.6 1.6 1 0 0 1 1 1 0 Hom_end-associated Hint POR PF01558.13 AMD20585.1 - 0.036 13.9 0.3 0.54 10.1 0.1 2.4 2 0 0 2 2 2 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Asp-B-Hydro_N PF05279.6 AMD20585.1 - 0.77 9.5 24.8 1.6 8.5 17.2 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CDC50 PF03381.10 AMD20586.1 - 1.1e-97 326.5 0.1 1.3e-97 326.3 0.1 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family UQ_con PF00179.21 AMD20587.1 - 1.9e-41 140.7 0.0 2.3e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.5 AMD20587.1 - 1.4e-27 94.9 2.7 2.3e-27 94.3 1.9 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain UBA_2 PF08587.6 AMD20587.1 - 0.053 13.7 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) HTH_37 PF13744.1 AMD20587.1 - 0.078 12.7 0.0 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain RWD PF05773.17 AMD20587.1 - 0.082 12.8 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 RWD domain MutS_V PF00488.16 AMD20588.1 - 1.3e-78 263.6 0.0 2.6e-78 262.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 AMD20588.1 - 1.3e-38 132.8 1.5 1.3e-38 132.8 1.0 2.0 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.15 AMD20588.1 - 4.2e-28 97.6 0.1 8.9e-28 96.5 0.1 1.6 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.13 AMD20588.1 - 1.8e-10 40.8 0.3 1.8e-10 40.8 0.2 2.3 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.12 AMD20588.1 - 2.2e-08 34.2 0.3 2.9e-07 30.6 0.0 2.7 2 0 0 2 2 2 1 MutS domain II AAA_14 PF13173.1 AMD20588.1 - 0.089 12.6 2.4 0.4 10.5 0.0 3.2 3 1 1 4 4 4 0 AAA domain Nif11 PF07862.6 AMD20588.1 - 0.092 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function Pkinase PF00069.20 AMD20589.1 - 2.8e-72 242.9 0.0 4.2e-72 242.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20589.1 - 1.2e-31 109.6 0.0 2.2e-30 105.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20589.1 - 1.9e-06 27.0 0.1 5.6e-05 22.2 0.0 2.4 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 AMD20589.1 - 0.024 13.7 0.0 0.041 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Trm112p PF03966.11 AMD20590.1 - 6e-19 68.1 0.1 7.6e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Thiolase_N PF00108.18 AMD20591.1 - 2.3e-98 328.3 3.4 2.9e-98 328.0 2.4 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 AMD20591.1 - 8.2e-45 151.1 0.4 8.2e-45 151.1 0.3 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 AMD20591.1 - 8.5e-07 28.7 3.3 2.2e-06 27.3 2.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AAA_17 PF13207.1 AMD20592.1 - 3.3e-13 50.5 0.0 4.3e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 AMD20592.1 - 9.4e-13 48.3 0.0 1e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.1 AMD20592.1 - 8.4e-11 41.9 0.0 1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD20592.1 - 2.2e-09 37.7 0.0 3.8e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.15 AMD20592.1 - 4.8e-09 36.0 0.0 6e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase CPT PF07931.7 AMD20592.1 - 1.1e-05 25.1 0.1 1.9e-05 24.3 0.1 1.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Cytidylate_kin2 PF13189.1 AMD20592.1 - 2.6e-05 24.2 0.0 0.00086 19.2 0.0 2.1 2 0 0 2 2 2 1 Cytidylate kinase-like family Thymidylate_kin PF02223.12 AMD20592.1 - 0.00039 19.8 0.0 0.16 11.2 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase PRK PF00485.13 AMD20592.1 - 0.0006 19.4 0.0 0.00098 18.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.7 AMD20592.1 - 0.0024 17.0 0.1 0.01 14.9 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin DUF2075 PF09848.4 AMD20592.1 - 0.003 16.5 0.0 0.0036 16.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 AMD20592.1 - 0.0032 17.5 0.0 0.0096 16.0 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.9 AMD20592.1 - 0.0068 16.1 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 AMD20592.1 - 0.0094 15.8 0.0 0.66 9.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AMD20592.1 - 0.011 15.1 0.7 0.035 13.5 0.5 2.0 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 AMD20592.1 - 0.012 15.6 0.0 0.078 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 AMD20592.1 - 0.014 15.4 0.1 0.057 13.4 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.1 AMD20592.1 - 0.026 14.2 0.2 0.15 11.8 0.4 2.2 2 1 0 2 2 1 0 Part of AAA domain ABC_tran PF00005.22 AMD20592.1 - 0.037 14.3 0.0 0.061 13.6 0.0 1.4 1 1 0 1 1 1 0 ABC transporter CoaE PF01121.15 AMD20592.1 - 0.056 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_29 PF13555.1 AMD20592.1 - 0.057 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 AMD20592.1 - 0.089 11.9 0.0 0.099 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SRP54 PF00448.17 AMD20592.1 - 0.091 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ETF PF01012.16 AMD20592.1 - 0.092 12.4 0.0 0.25 11.0 0.0 1.7 2 0 0 2 2 2 0 Electron transfer flavoprotein domain AAA PF00004.24 AMD20592.1 - 0.097 12.8 0.0 0.14 12.3 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 AMD20592.1 - 0.11 12.1 0.0 0.28 10.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.17 AMD20592.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.6 2 0 0 2 2 1 0 RNA helicase NB-ARC PF00931.17 AMD20592.1 - 0.12 11.2 0.1 0.23 10.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain ANF_receptor PF01094.23 AMD20592.1 - 0.14 10.9 0.0 0.59 8.8 0.0 1.8 1 1 1 2 2 2 0 Receptor family ligand binding region Pkinase PF00069.20 AMD20593.1 - 4.6e-50 170.1 0.1 1.4e-48 165.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20593.1 - 3e-20 72.3 0.1 9.5e-19 67.4 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20593.1 - 3.3e-06 26.2 0.0 5.1e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 AMD20593.1 - 0.00083 19.1 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 AMD20593.1 - 0.015 14.0 1.4 0.02 13.6 0.5 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase p450 PF00067.17 AMD20594.1 - 5e-98 328.6 0.0 5.8e-98 328.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_11 PF08241.7 AMD20595.1 - 0.04 14.4 0.0 0.15 12.5 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Sod_Fe_C PF02777.13 AMD20596.1 - 3.8e-38 129.5 0.8 8.1e-38 128.5 0.4 1.7 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 AMD20596.1 - 1.9e-25 88.9 2.6 4.3e-25 87.7 1.8 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Phos_pyr_kin PF08543.7 AMD20597.1 - 1.2e-11 44.2 0.0 1.7e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 AMD20597.1 - 4e-08 32.7 0.0 5.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CDC27 PF09507.5 AMD20598.1 - 5.2e-08 32.5 42.7 3.3e-06 26.6 27.6 2.4 2 1 0 2 2 2 2 DNA polymerase subunit Cdc27 DUF1675 PF07897.6 AMD20598.1 - 0.42 10.4 21.0 0.6 9.9 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) ATP-synt_C PF00137.16 AMD20599.1 - 1.3e-32 111.4 28.1 5.3e-19 67.8 7.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.3 AMD20599.1 - 5.2 6.7 10.2 0.45 10.1 0.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Nucleopor_Nup85 PF07575.8 AMD20600.1 - 4.9e-163 543.3 13.2 6e-163 543.0 9.2 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin Urb2 PF10441.4 AMD20601.1 - 1.3e-52 178.6 1.4 3.3e-52 177.3 1.0 1.7 1 0 0 1 1 1 1 Urb2/Npa2 family Voltage_CLC PF00654.15 AMD20602.1 - 1e-79 268.1 22.9 1e-79 268.1 15.9 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 AMD20602.1 - 4.5e-12 45.5 0.0 3.8e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 CBS domain Ribosomal_L7Ae PF01248.21 AMD20603.1 - 8.5e-27 92.5 0.1 1e-26 92.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 AMD20603.1 - 0.0035 17.1 0.0 0.0037 17.0 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.1 AMD20603.1 - 0.044 13.5 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 PELOTA RNA binding domain HECT PF00632.20 AMD20606.1 - 2.7e-86 289.6 6.8 4e-86 289.0 1.7 2.4 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Phi-29_GP3 PF05435.6 AMD20606.1 - 0.087 12.0 0.9 0.18 10.9 0.0 1.9 2 0 0 2 2 2 0 Phi-29 DNA terminal protein GP3 UCR_TM PF02921.9 AMD20607.1 - 1.1e-22 80.0 3.2 2e-22 79.2 2.2 1.4 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.21 AMD20607.1 - 3.5e-18 64.9 0.0 6e-18 64.2 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Transp_cyt_pur PF02133.10 AMD20607.1 - 0.1 11.1 0.2 0.12 10.8 0.1 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2235 PF09994.4 AMD20608.1 - 1.2e-82 277.4 0.0 1.7e-82 276.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SNF2_N PF00176.18 AMD20609.1 - 2.1e-78 263.1 0.3 5e-78 261.9 0.2 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD20609.1 - 1.4e-14 53.6 0.0 7e-14 51.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_11 PF13086.1 AMD20609.1 - 0.088 12.3 0.0 0.088 12.3 0.0 3.8 4 1 0 4 4 4 0 AAA domain Pet191_N PF10203.4 AMD20610.1 - 4.6e-26 90.6 4.4 5.9e-26 90.3 3.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 AMD20610.1 - 0.057 13.2 2.0 5 6.9 0.1 2.6 2 1 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 AMD20610.1 - 0.47 10.4 3.0 0.83 9.6 0.3 2.4 2 0 0 2 2 2 0 CHCH domain Rav1p_C PF12234.3 AMD20611.1 - 5.2e-239 794.6 7.1 5.2e-239 794.6 4.9 1.9 3 0 0 3 3 3 1 RAVE protein 1 C terminal WD40 PF00400.27 AMD20611.1 - 0.00051 19.8 1.1 2.5 8.1 0.0 5.4 5 0 0 5 5 5 1 WD domain, G-beta repeat Tir_receptor_C PF07489.6 AMD20611.1 - 0.3 10.8 0.4 0.52 10.0 0.3 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Pro_isomerase PF00160.16 AMD20612.1 - 5.9e-40 137.0 0.2 9e-40 136.4 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 AMD20612.1 - 1.5e-12 46.9 0.1 5e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 AMD20612.1 - 4.4e-09 35.5 6.7 1.3e-07 30.9 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20612.1 - 3.3e-08 32.8 5.0 3.3e-06 26.5 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 AMD20612.1 - 2.2e-05 24.3 0.1 0.00047 20.0 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20612.1 - 7.1e-05 22.3 5.0 0.00055 19.5 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 AMD20612.1 - 0.00021 21.8 0.0 0.00042 20.9 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 AMD20612.1 - 0.0073 16.4 4.2 0.12 12.5 0.1 3.1 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 adh_short_C2 PF13561.1 AMD20612.1 - 0.025 14.3 0.1 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Sec7 PF01369.15 AMD20613.1 - 6.7e-62 208.5 0.9 1.6e-61 207.3 0.2 1.9 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.2 AMD20613.1 - 9e-16 57.7 0.2 9e-16 57.7 0.2 3.3 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF2666 PF10869.3 AMD20613.1 - 0.0051 16.8 1.8 0.066 13.2 0.1 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2666) Mito_carr PF00153.22 AMD20614.1 - 2.8e-14 52.5 0.5 1.5e-09 37.4 0.1 3.4 4 0 0 4 4 4 2 Mitochondrial carrier protein OMPdecase PF00215.19 AMD20615.1 - 1.8e-74 249.9 0.0 2e-74 249.7 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family zf-Tim10_DDP PF02953.10 AMD20616.1 - 9.5e-21 72.8 5.0 1.5e-20 72.2 3.5 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Ku_PK_bind PF08785.6 AMD20616.1 - 0.0046 16.8 2.4 0.0054 16.6 1.6 1.1 1 0 0 1 1 1 1 Ku C terminal domain like Phasin_2 PF09361.5 AMD20616.1 - 0.058 13.4 0.2 0.39 10.7 0.1 2.0 1 1 1 2 2 2 0 Phasin protein Mmp37 PF09139.6 AMD20616.1 - 0.096 11.6 0.2 0.099 11.6 0.1 1.0 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 Gemini_AL1_M PF08283.6 AMD20616.1 - 0.099 12.4 0.2 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Geminivirus rep protein central domain DUF842 PF05811.8 AMD20616.1 - 0.48 9.8 7.1 0.85 9.0 4.9 1.4 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) TPP_enzyme_N PF02776.13 AMD20618.1 - 2.2e-39 134.6 0.0 3.9e-39 133.8 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 AMD20618.1 - 1.6e-22 79.7 0.0 4.9e-22 78.1 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 AMD20618.1 - 5.5e-22 77.9 0.0 1.3e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain DXP_synthase_N PF13292.1 AMD20618.1 - 0.004 16.1 0.2 0.007 15.3 0.2 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase tRNA-synt_2 PF00152.15 AMD20619.1 - 3.8e-72 242.8 0.0 5e-72 242.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AMD20619.1 - 9.4e-09 35.0 0.0 1.9e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 AMD20619.1 - 0.0012 18.0 0.0 0.36 9.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) zf-Nse PF11789.3 AMD20620.1 - 1.5e-18 66.0 0.3 3.9e-18 64.7 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 AMD20620.1 - 1.6e-08 34.1 0.9 5.1e-08 32.5 0.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.7 AMD20620.1 - 6.7e-06 25.4 0.7 0.00078 18.7 0.0 2.1 2 0 0 2 2 2 2 Rtf2 RING-finger U-box PF04564.10 AMD20620.1 - 0.00019 21.3 0.1 0.00052 19.9 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-RING_2 PF13639.1 AMD20620.1 - 0.00019 21.1 0.5 0.00039 20.1 0.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 AMD20620.1 - 0.00099 19.0 0.7 0.0021 18.0 0.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.15 AMD20620.1 - 0.0067 15.9 0.4 0.015 14.7 0.3 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4 PF00097.20 AMD20620.1 - 0.011 15.3 0.1 0.026 14.1 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 AMD20620.1 - 0.063 13.3 0.1 0.17 12.0 0.0 1.8 2 0 0 2 2 2 0 RING-H2 zinc finger SNARE PF05739.14 AMD20620.1 - 0.33 10.6 3.0 0.62 9.7 1.8 1.8 1 1 0 1 1 1 0 SNARE domain DUF3256 PF11644.3 AMD20621.1 - 0.0015 18.0 0.5 0.0022 17.5 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3256) RseA_C PF03873.8 AMD20621.1 - 0.25 11.2 1.5 4.4 7.2 0.1 2.5 2 0 0 2 2 2 0 Anti sigma-E protein RseA, C-terminal domain Rho_N PF07498.7 AMD20622.1 - 0.11 12.3 0.2 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain DUF2457 PF10446.4 AMD20622.1 - 3 6.4 10.0 4.3 5.9 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Phosphodiest PF01663.17 AMD20623.1 - 3.2e-69 233.9 1.7 4.1e-69 233.6 1.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 AMD20623.1 - 0.0001 21.6 0.1 0.00022 20.5 0.1 1.5 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.12 AMD20623.1 - 0.0058 15.1 0.0 0.013 13.9 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF229) YjeF_N PF03853.10 AMD20624.1 - 2.9e-25 88.8 0.1 5.2e-25 87.9 0.1 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 AMD20624.1 - 6.4e-08 33.0 1.8 1.9e-07 31.5 1.3 1.7 1 0 0 1 1 1 1 FDF domain Arm PF00514.18 AMD20625.1 - 1.9e-68 224.1 31.1 8.2e-12 44.4 0.0 11.0 11 0 0 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 AMD20625.1 - 5.8e-25 87.3 6.6 2e-06 27.9 0.1 6.5 2 2 5 7 7 7 6 HEAT repeats HEAT_EZ PF13513.1 AMD20625.1 - 3.5e-17 62.3 13.5 1.5e-05 25.2 0.2 7.4 6 2 2 8 8 8 5 HEAT-like repeat HEAT PF02985.17 AMD20625.1 - 2.5e-15 55.1 20.3 0.015 15.2 0.1 9.8 10 0 0 10 10 10 4 HEAT repeat Adaptin_N PF01602.15 AMD20625.1 - 1.5e-11 43.3 13.5 1.5e-08 33.4 2.3 2.4 1 1 0 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.8 AMD20625.1 - 4.8e-09 35.6 12.3 6.7e-08 31.9 2.6 3.5 2 1 0 3 3 3 2 Armadillo-like KAP PF05804.7 AMD20625.1 - 1.7e-08 32.8 1.4 6.2e-08 31.0 0.9 2.0 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) DUF2454 PF10521.4 AMD20625.1 - 5.8e-05 22.2 0.1 0.15 11.0 0.0 3.4 4 0 0 4 4 4 2 Protein of unknown function (DUF2454) V-ATPase_H_N PF03224.9 AMD20625.1 - 7.1e-05 22.0 8.5 0.0015 17.7 1.0 3.5 1 1 1 2 2 2 1 V-ATPase subunit H Vac14_Fab1_bd PF12755.2 AMD20625.1 - 0.00046 20.5 0.4 1.3 9.4 0.0 3.6 2 1 0 3 3 3 2 Vacuolar 14 Fab1-binding region V-ATPase_H_C PF11698.3 AMD20625.1 - 0.0028 17.5 3.7 0.099 12.5 0.1 4.1 2 2 4 6 6 6 1 V-ATPase subunit H DUF1981 PF09324.5 AMD20625.1 - 0.0031 17.0 0.4 16 5.0 0.0 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF1981) Cnd1 PF12717.2 AMD20625.1 - 0.014 15.2 7.2 0.26 11.1 0.1 4.7 3 2 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Phage_30_3 PF08010.6 AMD20625.1 - 0.088 12.2 0.0 0.27 10.7 0.0 1.9 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 LSM PF01423.17 AMD20626.1 - 2.3e-10 39.8 0.1 3.2e-10 39.4 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 AMD20626.1 - 0.025 14.5 0.0 0.031 14.2 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain UQ_con PF00179.21 AMD20628.1 - 2.8e-38 130.4 0.1 4e-38 129.9 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 AMD20628.1 - 0.031 14.1 0.0 0.063 13.1 0.0 1.6 1 0 0 1 1 1 0 RWD domain F-protein PF00469.15 AMD20628.1 - 0.044 13.1 2.2 0.061 12.6 1.5 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Vfa1 PF08432.5 AMD20628.1 - 0.44 10.5 3.9 0.58 10.1 2.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Alpha-amylase_C PF02806.13 AMD20629.1 - 1e-22 80.0 0.1 2.5e-22 78.8 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 AMD20629.1 - 3.9e-16 59.3 1.2 2.7e-15 56.5 0.1 2.6 2 1 0 2 2 2 1 Alpha amylase, catalytic domain CBM_48 PF02922.13 AMD20629.1 - 3.5e-12 46.1 0.1 1.2e-11 44.4 0.1 2.0 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Ribonuclease PF00545.15 AMD20629.1 - 0.3 11.1 2.3 1.2 9.2 0.0 2.8 3 0 0 3 3 3 0 ribonuclease APC_CDC26 PF10471.4 AMD20630.1 - 2.1e-15 57.2 6.9 5.7e-15 55.8 4.1 1.9 1 1 1 2 2 2 2 Anaphase-promoting complex APC subunit 1 MMgT PF10270.4 AMD20631.1 - 2.8e-24 85.5 0.2 3.3e-24 85.3 0.1 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter TcpE PF12648.2 AMD20631.1 - 0.12 12.5 0.4 0.3 11.2 0.1 1.7 1 1 1 2 2 2 0 TcpE family STAG PF08514.6 AMD20632.1 - 2e-09 37.1 1.1 1.3e-08 34.5 0.8 2.5 1 0 0 1 1 1 1 STAG domain HEAT PF02985.17 AMD20632.1 - 0.0016 18.3 5.6 0.022 14.7 0.0 4.7 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.1 AMD20632.1 - 0.011 15.9 0.1 0.17 12.1 0.0 3.0 3 0 0 3 3 3 0 HEAT repeats MFS_1 PF07690.11 AMD20634.1 - 2.2e-32 112.1 26.6 2.2e-32 112.1 18.4 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 AMD20634.1 - 3.6e-08 32.4 37.3 7.1e-07 28.1 10.4 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter DDT PF02791.12 AMD20634.1 - 0.084 12.6 0.1 0.69 9.7 0.0 2.3 2 0 0 2 2 2 0 DDT domain Zip PF02535.17 AMD20635.1 - 1.2e-32 113.2 4.4 3.9e-31 108.2 1.5 2.8 3 0 0 3 3 3 2 ZIP Zinc transporter Lectin_N PF03954.9 AMD20635.1 - 0.033 13.5 0.0 0.074 12.4 0.0 1.5 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain CN_hydrolase PF00795.17 AMD20635.1 - 0.12 11.7 0.0 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Carbon-nitrogen hydrolase SWIRM PF04433.12 AMD20636.1 - 2.3e-33 114.1 0.2 6.7e-33 112.6 0.2 1.9 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.12 AMD20636.1 - 3.4e-11 42.4 3.7 5.4e-11 41.8 2.6 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.26 AMD20636.1 - 2.1e-06 27.6 0.2 4.3e-06 26.6 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD20636.1 - 2.7e-05 24.1 0.3 0.00012 22.0 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain RusA PF05866.6 AMD20636.1 - 0.0051 17.2 1.0 0.0051 17.2 0.7 2.6 2 1 1 3 3 3 1 Endodeoxyribonuclease RusA THOC7 PF05615.8 AMD20636.1 - 0.0081 16.4 6.6 0.0081 16.4 4.6 2.4 2 1 0 2 2 2 1 Tho complex subunit 7 Elf1 PF05129.8 AMD20636.1 - 0.061 13.0 0.3 0.15 11.8 0.2 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like SNF2_N PF00176.18 AMD20637.1 - 1.7e-68 230.5 0.7 3.7e-68 229.5 0.5 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD20637.1 - 2.6e-18 65.6 0.0 1.3e-17 63.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD20637.1 - 6.5e-09 35.8 0.1 5.5e-08 32.8 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 AMD20637.1 - 2.6e-05 23.7 0.0 5.9e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 AMD20637.1 - 0.0088 16.1 0.1 0.058 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain cNMP_binding PF00027.24 AMD20638.1 - 6e-43 144.5 0.4 3.7e-21 74.7 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.12 AMD20638.1 - 2.4e-08 33.2 1.5 2.4e-08 33.2 1.0 2.2 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit DUF2051 PF09738.4 AMD20638.1 - 0.086 12.1 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 Double stranded RNA binding protein (DUF2051) Cupin_2 PF07883.6 AMD20638.1 - 1.4 8.4 3.4 9.8 5.7 0.1 2.4 2 0 0 2 2 2 0 Cupin domain Erg28 PF03694.8 AMD20639.1 - 5.1e-45 152.0 0.5 6.2e-45 151.7 0.3 1.1 1 0 0 1 1 1 1 Erg28 like protein DUF308 PF03729.8 AMD20639.1 - 0.0016 18.3 1.1 0.0053 16.7 0.0 2.2 3 0 0 3 3 3 1 Short repeat of unknown function (DUF308) F_actin_cap_B PF01115.12 AMD20640.1 - 6.3e-92 307.1 0.2 7.5e-92 306.9 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Pkinase PF00069.20 AMD20641.1 - 1.4e-58 198.0 8.0 1.6e-56 191.3 5.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20641.1 - 5.1e-21 74.9 3.7 1.8e-16 60.0 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 AMD20641.1 - 8e-07 29.0 0.1 3.5e-05 23.6 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 AMD20641.1 - 0.0068 16.0 0.9 0.021 14.4 0.5 2.0 1 1 1 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.9 AMD20641.1 - 0.039 13.0 0.2 0.077 12.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BRICHOS PF04089.9 AMD20642.1 - 0.012 15.4 0.4 0.043 13.6 0.1 2.1 2 0 0 2 2 2 0 BRICHOS domain Ubiquitin_3 PF14836.1 AMD20642.1 - 0.028 14.0 1.1 1.8 8.2 0.1 3.3 2 2 1 3 3 3 0 Ubiquitin-like domain bZIP_1 PF00170.16 AMD20643.1 - 3.4e-14 52.5 7.8 5.8e-14 51.7 5.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 AMD20643.1 - 3.9e-08 33.0 10.0 8.8e-08 31.8 6.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Inos-1-P_synth PF01658.12 AMD20643.1 - 0.085 12.6 0.6 0.16 11.8 0.4 1.4 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase bZIP_Maf PF03131.12 AMD20643.1 - 0.13 12.5 6.1 0.3 11.3 4.2 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor Pro-NT_NN PF07421.6 AMD20643.1 - 0.15 11.5 1.3 0.29 10.6 0.9 1.4 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor DUF2301 PF10063.4 AMD20645.1 - 0.037 14.2 2.8 0.073 13.2 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized integral membrane protein (DUF2301) Not3 PF04065.10 AMD20646.1 - 1.4e-91 305.9 24.9 1.4e-91 305.9 17.3 1.8 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 AMD20646.1 - 1e-24 86.9 1.4 1e-24 86.9 0.9 2.4 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family Syntaxin_2 PF14523.1 AMD20646.1 - 0.013 15.5 2.5 0.013 15.5 1.7 3.4 3 0 0 3 3 3 0 Syntaxin-like protein Ribosomal_S18 PF01084.15 AMD20646.1 - 0.14 12.0 0.9 0.35 10.7 0.6 1.7 1 0 0 1 1 1 0 Ribosomal protein S18 MerR-DNA-bind PF09278.6 AMD20646.1 - 0.42 11.0 5.1 0.38 11.1 0.5 2.8 2 0 0 2 2 2 0 MerR, DNA binding Syntaxin PF00804.20 AMD20646.1 - 1 9.5 22.1 0.037 14.1 1.0 4.0 4 0 0 4 4 4 0 Syntaxin AAA PF00004.24 AMD20647.1 - 6e-39 133.2 0.0 1.8e-38 131.7 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 AMD20647.1 - 2.9e-06 27.4 0.5 0.00024 21.2 0.1 3.4 3 1 0 3 3 2 1 AAA domain AAA_16 PF13191.1 AMD20647.1 - 5.6e-05 23.2 0.0 0.056 13.4 0.0 3.3 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.7 AMD20647.1 - 0.00012 21.1 0.0 0.00026 20.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Vps4_C PF09336.5 AMD20647.1 - 0.00015 21.5 0.0 0.00099 18.9 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_11 PF13086.1 AMD20647.1 - 0.00026 20.6 0.1 0.00074 19.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 AMD20647.1 - 0.00032 19.5 0.1 0.0028 16.4 0.0 2.1 2 0 0 2 2 2 1 TIP49 C-terminus AAA_2 PF07724.9 AMD20647.1 - 0.00041 20.2 0.0 0.001 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 AMD20647.1 - 0.00042 20.0 0.0 0.0023 17.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 AMD20647.1 - 0.00077 19.3 0.0 0.044 13.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.12 AMD20647.1 - 0.0035 16.7 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 AMD20647.1 - 0.0038 16.4 0.1 0.0081 15.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 AMD20647.1 - 0.0045 16.4 0.5 0.24 10.7 0.0 3.0 2 1 1 3 3 3 1 AAA domain ABC_tran PF00005.22 AMD20647.1 - 0.0073 16.6 0.0 0.028 14.7 0.0 2.0 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.1 AMD20647.1 - 0.0097 15.7 0.0 0.026 14.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD20647.1 - 0.0098 15.6 0.0 0.031 14.0 0.0 1.8 2 0 0 2 2 1 1 Part of AAA domain AAA_17 PF13207.1 AMD20647.1 - 0.013 16.3 0.0 0.063 14.0 0.0 2.3 2 0 0 2 2 1 0 AAA domain DUF815 PF05673.8 AMD20647.1 - 0.014 14.3 0.0 0.027 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Chromo PF00385.19 AMD20647.1 - 0.017 14.7 0.0 0.039 13.6 0.0 1.5 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain AAA_18 PF13238.1 AMD20647.1 - 0.037 14.3 0.0 0.22 11.8 0.0 2.4 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 AMD20647.1 - 0.048 13.3 0.3 0.35 10.4 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.1 AMD20647.1 - 0.061 13.2 0.1 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 AMD20647.1 - 0.065 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 AMD20647.1 - 0.091 11.9 0.0 0.24 10.6 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein Guanylate_kin PF00625.16 AMD20647.1 - 0.1 12.0 0.4 0.83 9.0 0.0 2.6 2 1 1 3 3 3 0 Guanylate kinase Metallophos PF00149.23 AMD20648.1 - 6.9e-24 84.3 4.8 6.9e-24 84.3 3.3 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DnaJ-X PF14308.1 AMD20649.1 - 7.8e-58 195.1 6.8 1.4e-57 194.2 4.7 1.4 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.26 AMD20649.1 - 7.8e-26 89.6 2.4 7.8e-26 89.6 1.6 3.0 3 0 0 3 3 3 1 DnaJ domain Peptidase_M32 PF02074.10 AMD20649.1 - 0.0026 16.4 2.0 0.004 15.8 1.4 1.2 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase Stork_head PF10264.4 AMD20649.1 - 0.15 12.2 0.0 0.41 10.8 0.0 1.7 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain Apq12 PF12716.2 AMD20650.1 - 0.0021 17.6 10.3 0.0042 16.7 7.1 1.5 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis BRI3BP PF14965.1 AMD20650.1 - 0.71 9.2 4.1 0.95 8.7 2.9 1.3 1 0 0 1 1 1 0 Negative regulator of p53/TP53 Complex1_LYR PF05347.10 AMD20651.1 - 7.7e-11 41.6 5.2 1.1e-10 41.1 3.6 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 AMD20651.1 - 2.7e-10 40.2 5.9 3.4e-10 39.9 4.1 1.1 1 0 0 1 1 1 1 Complex1_LYR-like ArsC PF03960.10 AMD20651.1 - 0.092 12.8 0.3 0.1 12.6 0.2 1.2 1 0 0 1 1 1 0 ArsC family Complex1_LYR_2 PF13233.1 AMD20651.1 - 0.15 12.5 4.9 0.2 12.1 3.4 1.2 1 0 0 1 1 1 0 Complex1_LYR-like DUF3573 PF12097.3 AMD20651.1 - 0.18 10.4 0.5 0.2 10.2 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Ofd1_CTDD PF10637.4 AMD20652.1 - 1.2e-90 303.3 0.9 4.2e-87 291.6 0.9 2.3 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 AMD20652.1 - 1.8e-16 60.4 0.1 1.2e-15 57.8 0.1 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily BAR_2 PF10455.4 AMD20653.1 - 1e-72 244.5 13.3 1e-72 244.5 9.2 1.8 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 AMD20653.1 - 3.5e-11 43.0 11.7 3.5e-11 43.0 8.1 2.5 1 1 1 2 2 2 1 BAR domain ATP-synt_ab PF00006.20 AMD20653.1 - 0.019 14.4 0.9 0.64 9.4 0.0 2.5 1 1 1 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Inhibitor_I24 PF10465.4 AMD20653.1 - 0.048 13.4 0.2 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 PinA peptidase inhibitor DUF2422 PF10337.4 AMD20653.1 - 0.1 11.3 6.0 0.013 14.3 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2422) TMEM247 PF15444.1 AMD20653.1 - 0.23 11.2 2.6 0.33 10.7 1.1 1.8 2 0 0 2 2 2 0 Transmembrane protein 247 UPF0223 PF05256.7 AMD20653.1 - 0.25 11.4 6.2 3.4 7.8 0.1 3.2 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0223) HtaA PF04213.8 AMD20653.1 - 0.36 11.0 2.4 0.7 10.1 0.0 2.5 3 1 0 3 3 3 0 Htaa DASH_Dad2 PF08654.5 AMD20653.1 - 0.66 9.9 5.5 8.3 6.4 0.1 3.1 2 1 1 3 3 3 0 DASH complex subunit Dad2 DUF3106 PF11304.3 AMD20653.1 - 2 8.8 8.6 0.57 10.6 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) BCDHK_Adom3 PF10436.4 AMD20654.1 - 6.4e-21 74.5 0.6 9.6e-21 73.9 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 AMD20654.1 - 6e-18 64.5 0.0 9.7e-18 63.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 AMD20654.1 - 0.00011 21.8 0.0 0.00018 21.1 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 AMD20654.1 - 0.029 14.1 0.0 0.071 12.8 0.0 1.5 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain Ribosomal_S18 PF01084.15 AMD20655.1 - 1.2e-20 73.1 0.0 2.6e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 Tim44 PF04280.10 AMD20656.1 - 6e-30 104.1 0.0 1.5e-29 102.8 0.0 1.7 1 0 0 1 1 1 1 Tim44-like domain Spore_III_AB PF09548.5 AMD20656.1 - 0.022 14.5 0.2 0.051 13.3 0.2 1.6 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) ChaB PF06150.7 AMD20656.1 - 0.067 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 ChaB CCDC32 PF14989.1 AMD20656.1 - 0.08 12.7 0.3 4 7.2 0.1 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing 32 RNA_pol_A_bac PF01000.21 AMD20658.1 - 3.8e-32 110.7 0.3 1.4e-31 108.9 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 AMD20658.1 - 4e-15 54.6 0.0 5.5e-15 54.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain His_biosynth PF00977.16 AMD20659.1 - 2.7e-27 95.5 0.1 3.3e-27 95.2 0.1 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein TM231 PF10149.4 AMD20659.1 - 0.061 12.3 0.1 0.097 11.6 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 231 DUF4602 PF15375.1 AMD20660.1 - 0.2 11.6 13.7 0.024 14.7 4.3 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4602) HLH PF00010.21 AMD20661.1 - 3.2e-15 55.5 1.1 1.4e-14 53.5 1.2 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain UCR_hinge PF02320.11 AMD20662.1 - 8.8e-26 89.6 4.0 1.3e-25 89.1 2.8 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Sigma70_ner PF04546.8 AMD20662.1 - 0.0044 16.6 8.2 0.0052 16.4 5.7 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region DUF506 PF04720.7 AMD20662.1 - 0.019 14.6 1.6 0.022 14.3 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF506) Nop14 PF04147.7 AMD20662.1 - 0.12 10.3 13.0 0.12 10.2 9.0 1.0 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.6 AMD20662.1 - 0.15 10.1 7.7 0.16 10.0 5.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop53 PF07767.6 AMD20662.1 - 0.16 10.9 7.3 0.19 10.6 5.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Bd3614_N PF14442.1 AMD20662.1 - 0.25 11.3 7.7 0.35 10.8 5.3 1.3 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal CENP-T PF15511.1 AMD20662.1 - 0.47 9.6 7.7 0.51 9.5 5.3 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T CDC45 PF02724.9 AMD20662.1 - 0.65 7.9 8.5 0.72 7.8 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.6 AMD20662.1 - 0.68 7.7 7.7 0.71 7.6 5.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Cwf_Cwc_15 PF04889.7 AMD20662.1 - 0.84 9.3 13.0 1 9.0 9.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein eIF-3c_N PF05470.7 AMD20662.1 - 1.1 7.2 5.4 1.1 7.2 3.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CobT PF06213.7 AMD20662.1 - 1.5 7.9 15.6 1.7 7.7 10.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mpp10 PF04006.7 AMD20662.1 - 1.7 6.8 13.8 1.8 6.8 9.6 1.0 1 0 0 1 1 1 0 Mpp10 protein Pox_RNA_Pol_19 PF05320.7 AMD20662.1 - 1.8 8.3 8.1 2.5 7.8 5.6 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF3381 PF11861.3 AMD20662.1 - 2 7.9 8.5 13 5.2 4.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Prothymosin PF03247.9 AMD20662.1 - 3.2 7.9 24.6 1.9 8.6 15.6 1.7 2 0 0 2 2 2 0 Prothymosin/parathymosin family DNA_pol_phi PF04931.8 AMD20662.1 - 4.3 4.9 18.3 3.9 5.1 12.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.6 AMD20662.1 - 6.1 6.6 8.0 8.7 6.1 5.5 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal TRAP_alpha PF03896.11 AMD20662.1 - 7.1 5.5 10.2 7.7 5.4 7.1 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.5 AMD20662.1 - 9.5 5.1 13.0 9.5 5.1 9.0 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.7 AMD20662.1 - 10 5.3 14.7 9.9 5.3 10.2 1.1 1 0 0 1 1 1 0 SDA1 Ribosomal_L29e PF01779.12 AMD20663.1 - 9.6e-23 79.7 11.4 1.4e-22 79.2 7.9 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family RRM_6 PF14259.1 AMD20664.1 - 1.5e-19 69.6 0.0 1.1e-09 38.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD20664.1 - 3.2e-18 65.1 0.0 7.7e-10 38.2 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20664.1 - 3.3e-05 23.6 0.0 0.0012 18.6 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L2_C PF03947.13 AMD20665.1 - 3.9e-41 139.8 3.1 6.5e-41 139.1 2.1 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 AMD20665.1 - 1e-13 51.0 0.1 2.3e-13 49.8 0.1 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain SMC_N PF02463.14 AMD20666.1 - 3.1e-68 229.2 16.1 2e-36 125.2 3.2 3.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 AMD20666.1 - 2.4e-19 69.4 0.8 1.2e-18 67.1 0.0 2.6 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 AMD20666.1 - 2.5e-09 37.5 9.8 4e-06 26.9 0.1 4.2 3 2 0 3 3 3 2 AAA domain AAA_29 PF13555.1 AMD20666.1 - 2.1e-05 23.9 0.0 5e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MscS_porin PF12795.2 AMD20666.1 - 0.00059 19.2 12.8 0.00059 19.2 8.8 6.6 4 2 3 7 7 7 3 Mechanosensitive ion channel porin domain IncA PF04156.9 AMD20666.1 - 0.0039 16.7 22.1 0.0039 16.7 15.3 7.4 3 2 4 7 7 7 4 IncA protein ATG16 PF08614.6 AMD20666.1 - 0.0061 16.4 20.5 0.0061 16.4 14.2 7.8 3 3 2 7 7 7 2 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 AMD20666.1 - 0.032 13.3 36.3 0.15 11.2 2.1 4.8 3 2 3 6 6 6 0 Reovirus sigma C capsid protein FUSC PF04632.7 AMD20666.1 - 1.5 7.1 2.6 2.7 6.3 0.1 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein family AAA_23 PF13476.1 AMD20666.1 - 3.2 8.0 126.2 0.0078 16.5 37.3 7.2 2 2 1 3 3 3 0 AAA domain FAD_binding_1 PF00667.15 AMD20667.1 - 7.5e-62 208.6 0.0 1.2e-61 207.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 AMD20667.1 - 4e-10 40.2 0.0 1.4e-09 38.5 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR PF01558.13 AMD20667.1 - 0.05 13.5 0.0 0.7 9.7 0.0 2.4 2 0 0 2 2 2 0 Pyruvate ferredoxin/flavodoxin oxidoreductase BAG PF02179.11 AMD20669.1 - 1.8e-14 53.5 2.1 4.4e-14 52.3 1.5 1.6 1 0 0 1 1 1 1 BAG domain CDC37_N PF03234.9 AMD20669.1 - 0.17 12.1 2.1 0.24 11.7 1.5 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Asp PF00026.18 AMD20670.1 - 1.5e-63 214.9 0.0 1.8e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD20670.1 - 7.6e-06 25.9 0.0 4.6e-05 23.4 0.0 2.3 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 AMD20670.1 - 0.014 15.8 0.3 1.1 9.7 0.1 3.1 2 1 0 2 2 2 0 Aspartyl protease Lum_binding PF00677.12 AMD20671.1 - 6.3e-49 163.7 5.2 1e-24 86.2 0.5 2.2 2 0 0 2 2 2 2 Lumazine binding domain WD40 PF00400.27 AMD20672.1 - 2.4e-09 36.7 11.1 0.00068 19.4 0.4 6.7 7 1 0 7 7 7 3 WD domain, G-beta repeat Apc4_WD40 PF12894.2 AMD20672.1 - 0.0055 16.1 0.0 0.069 12.6 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Sortase PF04203.8 AMD20672.1 - 0.0098 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 Sortase family Cut8_C PF08559.5 AMD20673.1 - 5.2e-42 143.0 0.3 7.6e-42 142.5 0.2 1.2 1 0 0 1 1 1 1 Cut8 six-helix bundle Cut8_M PF14483.1 AMD20673.1 - 3.1e-08 33.2 1.7 5.9e-08 32.3 1.2 1.5 1 0 0 1 1 1 1 Cut8 dimerisation domain DUF929 PF06053.6 AMD20674.1 - 0.079 12.0 0.0 0.094 11.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Sedlin_N PF04628.8 AMD20676.1 - 2.1e-44 150.6 0.0 3.2e-44 149.9 0.0 1.3 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 AMD20676.1 - 8e-06 25.6 0.1 1e-05 25.2 0.1 1.6 1 1 0 1 1 1 1 Sybindin-like family MIS13 PF08202.6 AMD20677.1 - 3.3e-70 236.5 3.3 6.2e-70 235.6 2.3 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family Med22 PF06179.7 AMD20678.1 - 1.3e-20 73.4 1.7 1.6e-20 73.1 1.2 1.0 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Polysacc_deac_1 PF01522.16 AMD20678.1 - 0.14 11.7 0.6 0.49 10.0 0.2 1.8 1 1 0 2 2 2 0 Polysaccharide deacetylase dUTPase PF00692.14 AMD20679.1 - 3.9e-44 149.2 0.0 4.7e-44 148.9 0.0 1.1 1 0 0 1 1 1 1 dUTPase DUF3086 PF11285.3 AMD20679.1 - 0.27 10.0 1.9 0.16 10.7 0.1 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) Peptidase_M16 PF00675.15 AMD20680.1 - 3.5e-30 104.7 0.2 8.4e-30 103.5 0.1 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 AMD20680.1 - 5.3e-09 36.0 0.1 4e-06 26.6 0.0 3.5 3 1 0 3 3 3 2 Peptidase M16 inactive domain Rap1_C PF11626.3 AMD20680.1 - 0.033 14.0 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Rrp15p PF07890.7 AMD20681.1 - 1.5e-32 112.3 13.5 1.5e-32 112.3 9.4 2.7 2 1 1 3 3 3 1 Rrp15p Daxx PF03344.10 AMD20681.1 - 0.48 8.8 37.6 0.61 8.5 26.1 1.0 1 0 0 1 1 1 0 Daxx Family Kinesin PF00225.18 AMD20682.1 - 4e-100 334.7 2.3 4e-100 334.7 1.6 3.0 3 0 0 3 3 3 1 Kinesin motor domain Reo_sigmaC PF04582.7 AMD20682.1 - 0.0014 17.8 2.2 0.0094 15.1 0.2 2.6 1 1 1 2 2 2 1 Reovirus sigma C capsid protein Ribonucleas_3_2 PF11469.3 AMD20682.1 - 0.052 13.7 0.2 0.2 11.8 0.1 2.0 1 0 0 1 1 1 0 Ribonuclease III Acyltransferase PF01553.16 AMD20683.1 - 8.1e-14 51.1 0.0 1.4e-13 50.4 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.16 AMD20684.1 - 0.00027 20.3 0.0 0.0008 18.8 0.0 1.8 1 1 0 1 1 1 1 Acyltransferase Ammonium_transp PF00909.16 AMD20686.1 - 6.6e-115 383.7 19.7 7.5e-115 383.5 13.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF373 PF04123.8 AMD20686.1 - 9.5 5.1 7.4 0.44 9.5 0.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF373) Metallophos PF00149.23 AMD20687.1 - 9e-38 129.6 0.3 1.5e-37 128.9 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_11 PF13414.1 AMD20687.1 - 2.9e-21 74.9 1.2 2.9e-17 62.0 0.1 2.4 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 AMD20687.1 - 6.7e-13 47.6 0.4 0.00027 20.4 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20687.1 - 5.6e-12 44.6 0.8 0.0041 16.9 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 AMD20687.1 - 2.9e-06 27.0 0.0 0.019 15.0 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat PPP5 PF08321.7 AMD20687.1 - 3.4e-06 26.9 0.1 0.0011 18.9 0.0 3.0 2 1 0 2 2 2 1 PPP5 TPR repeat region TPR_16 PF13432.1 AMD20687.1 - 5e-05 23.8 2.8 0.021 15.5 0.1 2.5 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 AMD20687.1 - 0.0008 19.2 1.2 0.014 15.2 0.1 2.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 AMD20687.1 - 0.0057 17.1 1.3 13 6.7 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 AMD20687.1 - 0.016 15.1 0.6 2.8 7.9 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 AMD20687.1 - 0.078 13.1 0.2 24 5.1 0.1 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 AMD20687.1 - 0.3 11.4 1.9 4.6 7.6 0.2 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat PH PF00169.24 AMD20688.1 - 2.6e-13 50.0 0.4 6.9e-13 48.7 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 AMD20688.1 - 0.042 14.0 0.2 0.36 11.1 0.0 2.6 3 0 0 3 3 3 0 Pleckstrin homology domain Flavin_Reduct PF01613.13 AMD20689.1 - 2.2e-23 82.8 0.1 1.2e-22 80.4 0.0 1.8 1 1 0 1 1 1 1 Flavin reductase like domain DUF790 PF05626.6 AMD20690.1 - 0.0093 14.5 0.0 0.013 14.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF790) Peptidase_C50 PF03568.12 AMD20691.1 - 5.8e-120 400.4 1.3 1e-119 399.6 0.1 2.0 2 0 0 2 2 2 1 Peptidase family C50 Telomere_reg-2 PF10193.4 AMD20692.1 - 1.5e-24 86.4 1.0 4.9e-24 84.7 0.7 2.0 1 0 0 1 1 1 1 Telomere length regulation protein RcsC PF09456.5 AMD20692.1 - 0.0024 17.4 0.0 0.0064 16.1 0.0 1.8 1 0 0 1 1 1 1 RcsC Alpha-Beta-Loop (ABL) RTTN_N PF14726.1 AMD20692.1 - 0.011 16.2 2.0 0.047 14.2 0.1 2.8 3 0 0 3 3 3 0 Rotatin, an armadillo repeat protein, centriole functioning DUF1788 PF08747.6 AMD20692.1 - 0.014 15.2 0.3 2.7 7.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1788) RabGAP-TBC PF00566.13 AMD20693.1 - 1.1e-50 172.1 0.5 3.1e-50 170.6 0.4 1.9 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.15 AMD20693.1 - 1.7e-14 53.1 0.1 4.7e-14 51.6 0.1 1.9 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.1 AMD20693.1 - 4.7e-05 22.9 0.7 0.096 12.6 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 AMD20693.1 - 0.00011 22.2 4.1 0.00037 20.5 0.6 3.0 2 0 0 2 2 2 1 EF-hand domain pair Vps36_ESCRT-II PF11605.3 AMD20693.1 - 0.029 14.1 1.1 0.078 12.7 0.0 2.4 3 0 0 3 3 3 0 Vacuolar protein sorting protein 36 Vps36 EF-hand_1 PF00036.27 AMD20693.1 - 0.79 9.1 6.0 0.69 9.3 0.1 3.3 3 0 0 3 3 3 0 EF hand Rhomboid PF01694.17 AMD20694.1 - 2.4e-28 99.0 19.5 5.1e-28 97.9 13.5 1.5 1 0 0 1 1 1 1 Rhomboid family DUF2207 PF09972.4 AMD20694.1 - 0.0029 16.2 0.8 0.0029 16.2 0.5 2.0 1 1 0 2 2 2 1 Predicted membrane protein (DUF2207) QCR10 PF09796.4 AMD20694.1 - 0.26 10.9 2.9 1.3 8.7 0.0 3.3 3 1 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Pescadillo_N PF06732.6 AMD20696.1 - 8.5e-119 395.9 3.3 8.5e-119 395.9 2.3 2.8 3 0 0 3 3 3 1 Pescadillo N-terminus BRCT PF00533.21 AMD20696.1 - 3.9e-11 42.9 0.1 2.4e-10 40.3 0.0 2.5 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain Med18 PF09637.5 AMD20697.1 - 4e-66 223.1 0.0 4.5e-66 222.9 0.0 1.0 1 0 0 1 1 1 1 Med18 protein VMA21 PF09446.5 AMD20698.1 - 5.3e-15 55.1 7.7 6.5e-15 54.8 5.4 1.1 1 0 0 1 1 1 1 VMA21-like domain DUF3816 PF12822.2 AMD20698.1 - 0.028 14.2 0.8 0.034 14.0 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) MscS_TM PF12794.2 AMD20698.1 - 0.085 11.4 0.3 0.091 11.3 0.2 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF3278 PF11683.3 AMD20698.1 - 0.1 12.5 0.3 0.11 12.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) DUF1430 PF07242.6 AMD20698.1 - 0.15 12.1 1.8 0.17 11.9 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1430) ATP-synt_S1 PF05827.7 AMD20699.1 - 0.017 14.4 0.0 0.034 13.4 0.0 1.6 1 1 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) AHS1 PF02682.11 AMD20699.1 - 0.068 12.6 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Allophanate hydrolase subunit 1 IF-2B PF01008.12 AMD20700.1 - 3e-76 256.0 0.0 3.6e-76 255.8 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Cyclin_N PF00134.18 AMD20701.1 - 5.6e-39 132.6 0.3 2.6e-38 130.4 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 AMD20701.1 - 1.7e-31 108.6 2.3 4.8e-31 107.1 0.0 2.4 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.18 AMD20702.1 - 1.8e-41 140.6 0.8 4.3e-41 139.4 0.5 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 AMD20702.1 - 2.7e-16 59.5 0.3 2.7e-16 59.5 0.2 2.1 3 0 0 3 3 3 1 Cyclin, C-terminal domain DUF2235 PF09994.4 AMD20702.1 - 0.04 13.2 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) LZ_Tnp_IS66 PF13007.2 AMD20703.1 - 0.74 10.5 5.9 1.3 9.7 4.1 1.4 1 0 0 1 1 1 0 Transposase C of IS166 homeodomain WD40 PF00400.27 AMD20704.1 - 2.6e-22 77.8 0.9 4.2e-07 29.6 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF3639 PF12341.3 AMD20705.1 - 6.3e-11 42.0 0.1 1.5e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3639) PQQ_2 PF13360.1 AMD20705.1 - 0.00028 20.4 0.0 0.4 10.1 0.0 2.6 2 0 0 2 2 2 2 PQQ-like domain DNA_gyraseA_C PF03989.8 AMD20705.1 - 0.039 13.2 0.0 5.8 6.3 0.0 2.9 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller WD40 PF00400.27 AMD20705.1 - 0.06 13.2 0.1 1.3 9.0 0.0 3.3 4 0 0 4 4 4 0 WD domain, G-beta repeat COG2 PF06148.6 AMD20706.1 - 1.6e-06 27.9 10.3 7.3e-06 25.8 6.6 2.2 1 1 1 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Spectrin PF00435.16 AMD20706.1 - 4.1e-05 23.7 4.2 6.4e-05 23.1 0.6 2.4 1 1 1 2 2 2 1 Spectrin repeat P22_AR_C PF10548.4 AMD20706.1 - 0.0084 15.9 0.3 0.91 9.4 0.0 3.1 3 1 1 4 4 4 1 P22AR C-terminal domain Exonuc_VII_L PF02601.10 AMD20706.1 - 0.083 12.0 3.4 0.1 11.7 2.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mating_N PF12731.2 AMD20706.1 - 2.1 8.2 13.1 0.32 10.9 3.7 2.9 1 1 1 3 3 3 0 Mating-type protein beta 1 Nup54 PF13874.1 AMD20707.1 - 9.9e-41 138.7 3.0 9.9e-41 138.7 2.1 2.7 2 1 1 3 3 3 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.1 AMD20707.1 - 7.1e-29 100.3 196.6 8.2e-10 38.9 29.7 5.2 1 1 4 5 5 5 4 Nucleoporin FG repeat region Tom5 PF10642.4 AMD20708.1 - 1.4e-20 72.6 0.3 1.5e-20 72.5 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Med26 PF08711.6 AMD20709.1 - 8e-14 50.8 1.5 1.4e-13 50.1 0.1 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Ribosom_S12_S23 PF00164.20 AMD20710.1 - 5.8e-41 138.7 0.7 6.8e-41 138.5 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 LisH PF08513.6 AMD20711.1 - 0.005 16.5 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 LisH Acetyltransf_1 PF00583.19 AMD20713.1 - 4.2e-11 42.7 0.0 6.9e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 AMD20713.1 - 6.7e-06 25.7 0.0 1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein JAB PF01398.16 AMD20713.1 - 0.0014 18.3 0.0 0.0036 17.0 0.0 1.6 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Acetyltransf_7 PF13508.1 AMD20713.1 - 0.0021 18.1 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 AMD20713.1 - 0.0044 17.1 0.0 0.0063 16.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 AMD20713.1 - 0.068 13.0 0.0 0.089 12.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AMD20713.1 - 0.069 13.0 0.1 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1196 PF06709.6 AMD20713.1 - 0.1 12.5 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1196) LSM14 PF12701.2 AMD20714.1 - 9.5e-26 89.4 2.2 1.3e-25 89.0 0.0 2.3 2 0 0 2 2 2 1 Scd6-like Sm domain FDF PF09532.5 AMD20714.1 - 2.3e-10 40.9 13.1 2.3e-10 40.9 9.1 3.0 1 1 1 2 2 2 1 FDF domain SM-ATX PF14438.1 AMD20714.1 - 0.0059 16.5 1.7 0.0067 16.3 0.0 2.0 2 1 0 2 2 2 1 Ataxin 2 SM domain Med15 PF09606.5 AMD20714.1 - 0.086 11.0 39.7 0.098 10.8 27.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MMR1 PF08505.5 AMD20714.1 - 2 8.3 22.9 3.3 7.6 15.9 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4175 PF13779.1 AMD20714.1 - 3.5 5.2 33.8 4.9 4.7 23.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Band_3_cyto PF07565.8 AMD20714.1 - 4.1 6.8 13.2 6.7 6.1 9.2 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Mito_carr PF00153.22 AMD20715.1 - 7.2e-56 185.9 1.3 1e-18 66.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.17 AMD20716.1 - 1.3e-70 232.9 6.0 2.3e-16 59.1 0.0 6.3 5 1 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD20716.1 - 2.8e-67 222.6 1.1 3e-15 55.9 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20716.1 - 1.8e-39 133.3 0.0 2.1e-09 37.1 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 AMD20716.1 - 0.0077 15.9 0.0 3.4 7.4 0.0 4.3 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 AMD20716.1 - 0.017 14.8 0.2 12 5.7 0.0 4.1 4 0 0 4 4 4 0 Limkain b1 CwfJ_C_1 PF04677.10 AMD20717.1 - 5.1e-33 113.3 1.5 9.6e-33 112.4 1.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 AMD20717.1 - 7.6e-21 74.4 0.7 1.5e-20 73.5 0.5 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Pkinase PF00069.20 AMD20718.1 - 1.8e-52 178.1 0.0 1.2e-51 175.3 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20718.1 - 2.9e-28 98.6 0.2 5.3e-19 68.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 AMD20718.1 - 0.00019 21.8 0.4 0.00045 20.6 0.2 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 AMD20718.1 - 0.00049 19.1 0.1 0.0073 15.3 0.0 2.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 AMD20718.1 - 0.042 13.5 0.0 0.21 11.3 0.0 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 AMD20718.1 - 0.046 12.7 0.1 0.16 10.9 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Nop PF01798.13 AMD20719.1 - 1.5e-34 118.4 0.2 4.6e-34 116.8 0.0 1.9 2 0 0 2 2 2 1 Putative snoRNA binding domain Prp31_C PF09785.4 AMD20719.1 - 1.7e-26 93.0 3.7 2.2e-26 92.7 1.7 1.9 2 0 0 2 2 2 1 Prp31 C terminal domain NOSIC PF08060.8 AMD20719.1 - 0.00042 20.0 0.1 0.00089 19.0 0.1 1.6 1 0 0 1 1 1 1 NOSIC (NUC001) domain RNA_pol_A_bac PF01000.21 AMD20720.1 - 3.9e-29 101.0 0.0 9.1e-29 99.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 AMD20720.1 - 2.3e-15 55.4 0.0 3e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF771 PF05595.6 AMD20720.1 - 0.074 12.9 0.1 0.95 9.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF771) CbiQ PF02361.11 AMD20721.1 - 0.23 10.9 2.1 1.3 8.5 0.5 2.0 2 0 0 2 2 2 0 Cobalt transport protein DUF485 PF04341.7 AMD20721.1 - 2.1 8.1 5.9 1.9 8.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function, DUF485 Nrap PF03813.9 AMD20722.1 - 0 1189.3 4.6 0 1189.1 3.2 1.0 1 0 0 1 1 1 1 Nrap protein IFP_35_N PF07334.8 AMD20722.1 - 0.024 14.5 0.0 0.081 12.9 0.0 1.8 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Glyco_hydro_72 PF03198.9 AMD20723.1 - 2.4e-140 466.9 6.4 2.9e-140 466.7 4.5 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.12 AMD20723.1 - 1.6e-05 23.9 0.2 2.4e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.13 AMD20723.1 - 0.0075 15.4 0.1 0.023 13.8 0.1 1.7 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DUF1517 PF07466.6 AMD20723.1 - 1.8 7.4 11.5 3 6.7 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) bZIP_1 PF00170.16 AMD20724.1 - 8.7e-05 22.3 10.5 8.7e-05 22.3 7.3 2.2 1 1 1 2 2 2 1 bZIP transcription factor Hap4_Hap_bind PF10297.4 AMD20724.1 - 0.00028 20.6 5.4 0.00048 19.9 3.8 1.3 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_Maf PF03131.12 AMD20724.1 - 0.0022 18.2 4.7 0.0049 17.1 3.2 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor RNase_HII PF01351.13 AMD20724.1 - 0.031 13.9 1.8 0.043 13.4 1.2 1.2 1 0 0 1 1 1 0 Ribonuclease HII KIAA1430 PF13879.1 AMD20724.1 - 0.14 12.5 14.3 0.45 10.9 2.2 2.3 1 1 1 2 2 2 0 KIAA1430 homologue bZIP_2 PF07716.10 AMD20724.1 - 0.16 11.7 20.1 0.41 10.5 10.1 2.6 1 1 1 2 2 2 0 Basic region leucine zipper APG6 PF04111.7 AMD20724.1 - 2.6 7.0 7.2 3.5 6.5 5.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 WSC PF01822.14 AMD20725.1 - 1e-12 47.7 13.9 1e-12 47.7 9.6 1.8 2 0 0 2 2 2 1 WSC domain Plasmodium_Vir PF05795.6 AMD20725.1 - 0.0006 19.1 0.3 0.00084 18.6 0.2 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF1191 PF06697.7 AMD20725.1 - 0.0026 16.6 0.0 0.0039 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) Herpes_gE PF02480.11 AMD20725.1 - 0.0093 14.2 0.0 0.013 13.8 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E TMEM51 PF15345.1 AMD20725.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 Mid2 PF04478.7 AMD20725.1 - 0.026 13.9 0.5 0.045 13.1 0.3 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF1517 PF07466.6 AMD20725.1 - 0.044 12.7 0.3 0.044 12.7 0.2 2.1 1 1 1 2 2 1 0 Protein of unknown function (DUF1517) Prim_Zn_Ribbon PF08273.7 AMD20725.1 - 0.048 13.7 0.4 0.048 13.7 0.3 2.1 2 0 0 2 2 1 0 Zinc-binding domain of primase-helicase Syndecan PF01034.15 AMD20725.1 - 0.067 12.8 2.1 0.083 12.5 0.3 1.9 2 0 0 2 2 2 0 Syndecan domain MadL PF03817.8 AMD20725.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Malonate transporter MadL subunit TMEM154 PF15102.1 AMD20725.1 - 0.11 12.1 0.2 0.21 11.2 0.1 1.4 1 1 0 1 1 1 0 TMEM154 protein family DUF2408 PF10303.4 AMD20726.1 - 7.9e-58 194.3 13.0 2.1e-34 118.5 0.4 4.8 2 2 3 5 5 5 4 Protein of unknown function (DUF2408) NPV_P10 PF05531.7 AMD20726.1 - 0.0015 18.7 5.6 1.2 9.3 0.4 4.3 2 1 2 4 4 4 2 Nucleopolyhedrovirus P10 protein AATF-Che1 PF13339.1 AMD20726.1 - 0.029 14.5 7.5 0.14 12.2 0.4 3.9 4 1 0 4 4 4 0 Apoptosis antagonizing transcription factor zf-C4H2 PF10146.4 AMD20726.1 - 0.24 11.3 9.0 0.099 12.6 0.9 2.7 1 1 1 2 2 2 0 Zinc finger-containing protein DUF2205 PF10224.4 AMD20726.1 - 0.39 10.3 5.7 0.35 10.4 1.7 2.6 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) AhpC-TSA PF00578.16 AMD20727.1 - 2.4e-26 91.8 0.0 3.7e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AMD20727.1 - 1.4e-16 60.3 0.0 2.3e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 AMD20727.1 - 0.026 14.4 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme Rota_NS26 PF01525.11 AMD20727.1 - 0.034 13.9 3.1 3.1 7.5 0.3 2.4 2 0 0 2 2 2 0 Rotavirus NS26 DUF1644 PF07800.7 AMD20727.1 - 0.11 12.2 0.1 0.25 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Adap_comp_sub PF00928.16 AMD20728.1 - 7e-85 284.2 0.0 9.3e-85 283.8 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 AMD20728.1 - 1.4e-05 24.7 0.6 2.6e-05 23.9 0.4 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TPP1 PF10341.4 AMD20729.1 - 1e-20 73.6 0.0 1.4e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD Urm1 PF09138.6 AMD20730.1 - 4.8e-35 119.5 0.6 5.4e-35 119.4 0.4 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 AMD20730.1 - 0.00018 21.8 0.0 0.00022 21.5 0.0 1.2 1 0 0 1 1 1 1 ThiS family YchF-GTPase_C PF06071.8 AMD20730.1 - 0.063 13.0 0.0 0.37 10.6 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF933) PDZ PF00595.19 AMD20731.1 - 9.3e-08 32.1 0.1 1.4e-07 31.6 0.1 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 AMD20731.1 - 3.8e-06 26.6 0.0 7.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.9 AMD20731.1 - 6.9e-06 26.0 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain DUF288 PF03385.12 AMD20731.1 - 0.033 12.6 0.0 0.04 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF288 Septin PF00735.13 AMD20731.1 - 0.064 12.2 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 Septin bZIP_1 PF00170.16 AMD20732.1 - 1.7e-14 53.5 7.8 3e-14 52.6 5.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 AMD20732.1 - 2.3e-12 46.5 7.8 2.3e-12 46.5 5.4 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.12 AMD20732.1 - 0.0014 18.8 3.0 0.0031 17.7 2.1 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF904 PF06005.7 AMD20732.1 - 0.11 12.7 3.7 0.2 11.9 2.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Gti1_Pac2 PF09729.4 AMD20733.1 - 6.1e-57 192.1 0.0 6.1e-57 192.1 0.0 2.5 2 1 0 2 2 2 1 Gti1/Pac2 family PAT1 PF09770.4 AMD20733.1 - 0.14 10.3 30.9 0.19 9.9 21.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Mito_carr PF00153.22 AMD20734.1 - 6.1e-72 237.4 5.0 3e-24 84.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Thioredoxin PF00085.15 AMD20735.1 - 1.3e-23 82.6 0.3 1.3e-19 69.7 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 AMD20735.1 - 1.4e-06 28.2 6.7 0.00028 20.7 0.1 4.1 3 1 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_4 PF13462.1 AMD20735.1 - 0.002 18.1 0.1 0.0052 16.8 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 AMD20735.1 - 0.26 11.4 3.6 0.43 10.7 0.0 3.0 3 0 0 3 3 3 0 Thioredoxin-like SNARE PF05739.14 AMD20736.1 - 1.2e-07 31.3 1.0 1.6e-07 30.8 0.7 1.3 1 0 0 1 1 1 1 SNARE domain Sec20 PF03908.8 AMD20736.1 - 0.0018 17.9 2.7 0.013 15.1 0.2 2.1 1 1 1 2 2 2 1 Sec20 Use1 PF09753.4 AMD20736.1 - 0.022 14.1 1.2 0.029 13.8 0.6 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 Synaptobrevin PF00957.16 AMD20736.1 - 0.032 13.8 4.3 0.055 13.0 3.0 1.4 1 1 0 1 1 1 0 Synaptobrevin Tropomyosin_1 PF12718.2 AMD20736.1 - 0.043 13.6 0.2 0.055 13.3 0.1 1.2 1 0 0 1 1 1 0 Tropomyosin like AIP3 PF03915.8 AMD20736.1 - 0.11 11.4 0.4 0.12 11.2 0.3 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 MttA_Hcf106 PF02416.11 AMD20736.1 - 5.2 6.2 6.4 0.66 9.1 1.0 2.1 3 0 0 3 3 3 0 mttA/Hcf106 family ParA PF10609.4 AMD20737.1 - 2e-34 117.2 0.0 3.8e-34 116.4 0.0 1.5 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 AMD20737.1 - 1.4e-14 54.0 0.0 2.1e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 AMD20737.1 - 1e-07 31.2 0.0 3.3e-07 29.6 0.0 1.7 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.10 AMD20737.1 - 3.4e-06 26.3 0.3 1.9e-05 23.8 0.1 2.2 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_31 PF13614.1 AMD20737.1 - 7.2e-06 26.0 0.0 0.00012 22.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain Fer4_NifH PF00142.13 AMD20737.1 - 0.00024 20.3 0.1 0.52 9.4 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family YhjQ PF06564.7 AMD20737.1 - 0.0012 18.2 0.0 0.0022 17.3 0.0 1.4 1 1 0 1 1 1 1 YhjQ protein AAA_25 PF13481.1 AMD20737.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 AMD20737.1 - 0.027 13.2 0.1 0.049 12.4 0.1 1.3 1 0 0 1 1 1 0 ArgK protein DUF258 PF03193.11 AMD20737.1 - 0.12 11.5 0.1 0.27 10.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_26 PF13500.1 AMD20737.1 - 0.14 11.7 0.4 0.64 9.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain IDO PF01231.13 AMD20738.1 - 0.0044 15.5 1.1 0.0074 14.7 0.7 1.4 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Fzo_mitofusin PF04799.8 AMD20738.1 - 0.0085 15.4 4.2 0.013 14.8 2.9 1.3 1 0 0 1 1 1 1 fzo-like conserved region Syntaxin PF00804.20 AMD20738.1 - 0.0088 16.1 2.5 0.03 14.4 1.8 1.9 1 0 0 1 1 1 1 Syntaxin Nup54 PF13874.1 AMD20738.1 - 0.026 14.1 1.4 0.067 12.8 0.9 1.7 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Syntaxin-6_N PF09177.6 AMD20738.1 - 0.033 14.5 3.7 0.036 14.4 0.3 2.5 3 0 0 3 3 3 0 Syntaxin 6, N-terminal NPV_P10 PF05531.7 AMD20738.1 - 0.092 13.0 3.8 2.1 8.6 2.6 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein HTH_26 PF13443.1 AMD20738.1 - 0.12 12.5 0.4 0.88 9.8 0.0 2.5 3 0 0 3 3 3 0 Cro/C1-type HTH DNA-binding domain Baculo_PEP_C PF04513.7 AMD20738.1 - 0.16 11.7 6.1 0.27 11.0 4.2 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.8 AMD20738.1 - 0.17 10.9 2.5 0.24 10.4 1.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein Pneumovirus_M2 PF06436.6 AMD20738.1 - 0.22 10.7 6.9 0.36 10.0 4.7 1.4 1 1 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) Prominin PF05478.6 AMD20738.1 - 5.1 4.5 7.1 8.2 3.8 4.9 1.3 1 0 0 1 1 1 0 Prominin Prefoldin_2 PF01920.15 AMD20739.1 - 3.7e-21 74.8 5.0 4.1e-21 74.7 3.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit FlaC_arch PF05377.6 AMD20739.1 - 0.017 15.0 0.8 0.017 15.0 0.5 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Spc24 PF08286.6 AMD20739.1 - 0.031 13.9 2.0 2.8 7.6 0.1 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 CENP-F_leu_zip PF10473.4 AMD20739.1 - 0.084 12.7 4.3 1.3 8.8 0.3 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2935 PF11155.3 AMD20739.1 - 0.11 12.5 0.4 0.14 12.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Baculo_PEP_C PF04513.7 AMD20739.1 - 0.16 11.7 1.6 0.23 11.2 0.2 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlxA PF14282.1 AMD20739.1 - 0.34 10.8 3.8 0.75 9.7 0.3 2.0 2 0 0 2 2 2 0 FlxA-like protein DUF904 PF06005.7 AMD20739.1 - 0.5 10.7 4.5 17 5.7 3.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DASH_Dad3 PF08656.5 AMD20739.1 - 0.66 9.7 3.1 1.4 8.6 0.3 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad3 DUF972 PF06156.8 AMD20739.1 - 0.73 10.2 3.4 2.3 8.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DDOST_48kD PF03345.9 AMD20740.1 - 1.5e-126 422.3 1.1 1.8e-126 422.1 0.8 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta DUF4349 PF14257.1 AMD20741.1 - 0.0017 17.6 1.3 0.002 17.4 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) CotH PF08757.6 AMD20741.1 - 0.002 17.4 0.3 0.002 17.4 0.2 1.0 1 0 0 1 1 1 1 CotH protein YvrJ PF12841.2 AMD20741.1 - 0.0075 15.5 0.6 0.021 14.0 0.1 1.9 2 0 0 2 2 2 1 YvrJ protein family Tropomyosin_1 PF12718.2 AMD20741.1 - 0.026 14.3 2.3 0.029 14.1 1.6 1.2 1 0 0 1 1 1 0 Tropomyosin like Laminin_I PF06008.9 AMD20741.1 - 0.048 12.9 0.6 0.049 12.9 0.4 1.0 1 0 0 1 1 1 0 Laminin Domain I Fzo_mitofusin PF04799.8 AMD20741.1 - 0.053 12.9 0.5 0.054 12.8 0.4 1.0 1 0 0 1 1 1 0 fzo-like conserved region CK2S PF15011.1 AMD20741.1 - 0.066 12.9 0.6 0.074 12.8 0.4 1.1 1 0 0 1 1 1 0 Casein Kinase 2 substrate DnaG_DnaB_bind PF08278.6 AMD20741.1 - 0.098 12.8 0.3 0.15 12.3 0.2 1.4 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding AKNA PF12443.3 AMD20741.1 - 0.1 12.6 0.1 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 AT-hook-containing transcription factor PNPase PF03726.9 AMD20741.1 - 0.11 12.8 0.7 0.13 12.5 0.5 1.2 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain PilJ PF13675.1 AMD20741.1 - 0.12 12.7 0.1 0.12 12.6 0.1 1.1 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF2951 PF11166.3 AMD20741.1 - 0.37 10.6 2.3 0.43 10.4 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Syja_N PF02383.13 AMD20742.1 - 1.9e-60 204.2 1.7 3e-60 203.6 1.2 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 AMD20742.1 - 3.7e-24 86.0 0.0 5.4e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Wzt_C PF14524.1 AMD20743.1 - 0.038 13.6 0.5 0.067 12.8 0.3 1.3 1 0 0 1 1 1 0 Wzt C-terminal domain Nop16 PF09420.5 AMD20744.1 - 7.9e-55 185.4 7.3 9.2e-55 185.1 5.1 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 PMI_typeI PF01238.16 AMD20745.1 - 9.2e-147 488.8 0.0 1.1e-146 488.6 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.14 AMD20745.1 - 5e-06 26.2 0.0 0.0036 16.9 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_2 PF07883.6 AMD20745.1 - 0.11 12.0 0.0 4.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Cupin domain Hexapep PF00132.19 AMD20746.1 - 2.1e-05 23.8 15.6 0.0094 15.4 3.7 5.0 4 1 1 5 5 5 3 Bacterial transferase hexapeptide (six repeats) E1-E2_ATPase PF00122.15 AMD20746.1 - 0.058 12.4 0.1 0.081 11.9 0.0 1.4 1 0 0 1 1 1 0 E1-E2 ATPase Hexapep_2 PF14602.1 AMD20746.1 - 1.8 8.2 15.9 5 6.7 6.3 3.6 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase GDA1_CD39 PF01150.12 AMD20747.1 - 4.7e-130 433.9 0.6 6.7e-130 433.4 0.4 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family TFIIB PF00382.14 AMD20748.1 - 1.7e-49 165.4 4.1 8.8e-26 89.5 1.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 AMD20748.1 - 1.4e-13 49.9 0.8 2.4e-13 49.1 0.5 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Poxvirus PF06227.7 AMD20748.1 - 0.063 12.8 0.2 0.091 12.3 0.1 1.4 1 0 0 1 1 1 0 dsDNA Poxvirus Cyclin_C PF02984.14 AMD20748.1 - 0.093 12.6 0.2 0.27 11.1 0.0 1.9 2 1 0 2 2 2 0 Cyclin, C-terminal domain Rubredoxin PF00301.15 AMD20748.1 - 0.37 10.7 1.8 37 4.3 0.0 3.2 3 0 0 3 3 3 0 Rubredoxin GN3L_Grn1 PF08701.6 AMD20749.1 - 1.2e-24 86.0 17.8 1.2e-24 86.0 12.4 2.3 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 AMD20749.1 - 4.8e-23 81.3 0.1 1.1e-15 57.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD20749.1 - 5.1e-09 35.5 0.0 1.6e-07 30.7 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 AMD20749.1 - 7.7e-06 25.4 0.1 0.014 14.8 0.0 2.8 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 AMD20749.1 - 8.4e-05 22.4 6.6 0.096 12.5 0.0 3.8 2 2 1 3 3 3 2 Dynamin family DUF258 PF03193.11 AMD20749.1 - 0.0002 20.6 0.2 0.00037 19.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 AMD20749.1 - 0.0023 18.4 0.2 0.6 10.6 0.0 2.8 2 0 0 2 2 2 1 Miro-like protein cobW PF02492.14 AMD20749.1 - 0.021 14.2 0.1 1.3 8.4 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 AMD20749.1 - 0.027 14.7 3.9 0.088 13.1 0.0 3.3 4 0 0 4 4 4 0 AAA domain ArgK PF03308.11 AMD20749.1 - 0.035 12.8 0.0 0.035 12.8 0.0 2.0 2 0 0 2 2 2 0 ArgK protein AAA_17 PF13207.1 AMD20749.1 - 0.52 11.1 0.0 0.52 11.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain CAP_GLY PF01302.20 AMD20750.1 - 1.5e-17 63.0 0.3 2.9e-17 62.0 0.2 1.5 1 0 0 1 1 1 1 CAP-Gly domain LRR_8 PF13855.1 AMD20750.1 - 2e-15 56.3 23.5 7.3e-09 35.2 2.7 5.3 3 1 4 7 7 7 5 Leucine rich repeat LRR_4 PF12799.2 AMD20750.1 - 3.1e-15 55.3 35.7 1.4e-06 27.7 2.3 7.0 2 2 5 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 AMD20750.1 - 1.8e-10 39.7 26.1 0.66 10.2 0.3 9.3 7 1 2 9 9 9 5 Leucine Rich repeat LRR_7 PF13504.1 AMD20750.1 - 1e-08 33.9 20.6 2.5 8.6 0.0 9.0 8 1 0 8 8 8 4 Leucine rich repeat LRR_1 PF00560.28 AMD20750.1 - 5.7e-07 28.6 34.2 0.004 16.9 0.3 9.2 8 1 1 9 9 9 4 Leucine Rich Repeat LysM PF01476.15 AMD20750.1 - 2.2e-05 24.2 0.5 0.0002 21.1 0.0 3.1 3 0 0 3 3 3 1 LysM domain LRR_9 PF14580.1 AMD20750.1 - 0.00068 19.2 7.0 0.0038 16.8 2.3 2.7 2 1 0 2 2 2 1 Leucine-rich repeat PUA PF01472.15 AMD20751.1 - 1.6e-21 75.8 0.1 2.9e-21 74.9 0.0 1.5 2 0 0 2 2 2 1 PUA domain DUF1947 PF09183.5 AMD20751.1 - 0.061 13.0 0.5 0.13 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) Helicase_C PF00271.26 AMD20752.1 - 3.4e-20 71.6 0.3 8.8e-20 70.3 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AMD20752.1 - 8.3e-20 70.9 0.0 7.3e-19 67.8 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.10 AMD20752.1 - 8.6e-17 61.5 3.1 2.5e-16 60.0 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 AMD20752.1 - 0.00015 21.8 0.0 0.0067 16.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain PhoH PF02562.11 AMD20752.1 - 0.0092 15.2 0.0 0.023 13.9 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein Sec3_C PF09763.4 AMD20753.1 - 3e-147 491.7 20.5 3e-147 491.7 14.2 1.9 3 0 0 3 3 3 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 AMD20753.1 - 1.3e-23 82.6 0.2 4.2e-23 81.0 0.1 2.0 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH NTF2 PF02136.15 AMD20754.1 - 5.1e-34 117.1 0.5 5.7e-34 117.0 0.4 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.1 AMD20754.1 - 0.0015 17.5 0.2 0.0019 17.3 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) DUF4440 PF14534.1 AMD20754.1 - 0.079 13.1 0.0 0.098 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DUF3210 PF11489.3 AMD20755.1 - 5.8e-15 55.0 33.6 5.8e-15 55.0 23.3 3.7 2 1 0 3 3 3 2 Protein of unknown function (DUF3210) DnaJ-X PF14308.1 AMD20756.1 - 3.2e-60 202.9 1.0 3.2e-60 202.9 0.7 2.3 2 1 0 2 2 2 2 X-domain of DnaJ-containing DnaJ PF00226.26 AMD20756.1 - 2.3e-23 81.6 1.4 2.3e-23 81.6 0.9 2.3 2 0 0 2 2 2 1 DnaJ domain Hid1 PF12722.2 AMD20756.1 - 1 6.9 11.3 1.4 6.4 7.8 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM60A PF15396.1 AMD20756.1 - 3.8 7.1 12.0 9.6 5.8 8.3 1.7 1 0 0 1 1 1 0 Protein Family FAM60A Ndc1_Nup PF09531.5 AMD20756.1 - 7.4 4.8 8.8 11 4.3 6.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Methyltransf_6 PF03737.10 AMD20757.1 - 1.1e-28 99.9 0.0 1.5e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Demethylmenaquinone methyltransferase RRM_1 PF00076.17 AMD20758.1 - 3.2e-15 55.4 0.0 5.1e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD20758.1 - 4.5e-12 45.7 0.0 6.3e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20758.1 - 6.1e-09 35.5 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2004 PF09406.5 AMD20758.1 - 0.036 14.1 0.3 0.36 10.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2004) AraC_binding PF02311.14 AMD20758.1 - 0.11 12.2 0.9 0.57 9.8 0.1 2.0 2 0 0 2 2 2 0 AraC-like ligand binding domain EF-hand_4 PF12763.2 AMD20759.1 - 3.5e-26 90.9 0.0 5.5e-13 48.5 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 AMD20759.1 - 8.1e-08 31.0 0.0 0.00077 18.5 0.0 3.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 AMD20759.1 - 3.4e-07 30.3 0.0 0.0009 19.3 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 AMD20759.1 - 1e-06 28.0 0.1 0.21 11.5 0.0 4.5 4 0 0 4 4 4 2 EF-hand domain DUF1720 PF08226.6 AMD20759.1 - 2e-05 24.5 64.3 8.3e-05 22.5 21.5 9.3 4 2 5 9 9 9 5 Domain of unknown function (DUF1720) EF-hand_8 PF13833.1 AMD20759.1 - 0.034 13.7 0.0 0.42 10.2 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_5 PF13202.1 AMD20759.1 - 0.042 13.2 0.0 0.12 11.8 0.0 1.8 1 0 0 1 1 1 0 EF hand ALMT PF11744.3 AMD20759.1 - 0.36 9.4 2.9 0.92 8.0 2.0 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter SRP1_TIP1 PF00660.12 AMD20760.1 - 8.7e-24 83.3 0.1 1.2e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Seripauperin and TIP1 family ARD PF03079.9 AMD20761.1 - 3.1e-41 140.9 0.4 3.5e-41 140.7 0.3 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 AMD20761.1 - 4.1e-08 32.6 0.1 7.5e-08 31.7 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 AMD20761.1 - 0.0031 17.1 0.0 0.0053 16.4 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 AMD20761.1 - 0.0038 16.6 0.0 0.0064 15.9 0.0 1.3 1 0 0 1 1 1 1 Cupin PQ-loop PF04193.9 AMD20762.1 - 8.3e-10 38.0 8.7 1.3e-09 37.4 2.6 4.2 4 1 1 5 5 5 3 PQ loop repeat COX2-transmemb PF09125.5 AMD20762.1 - 0.54 9.8 2.9 2 8.0 0.1 2.8 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane TauD PF02668.11 AMD20763.1 - 2.6e-48 164.9 0.0 3.6e-48 164.4 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 AMD20763.1 - 0.084 13.2 0.0 0.65 10.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF971) TP6A_N PF04406.9 AMD20764.1 - 1e-12 47.4 0.0 2.3e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Type IIB DNA topoisomerase EMP24_GP25L PF01105.19 AMD20765.1 - 2.6e-35 121.8 0.0 3e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RPN7 PF10602.4 AMD20766.1 - 4.8e-52 175.8 4.4 8.8e-52 175.0 3.0 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 AMD20766.1 - 3.1e-16 59.6 1.0 9.7e-16 57.9 0.2 2.1 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 AMD20766.1 - 0.00084 19.1 0.2 0.0024 17.6 0.0 1.8 2 0 0 2 2 2 1 COP9 signalosome, subunit CSN8 TPR_12 PF13424.1 AMD20766.1 - 0.0056 16.6 2.4 0.061 13.2 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.1 AMD20766.1 - 0.0076 15.3 0.2 0.019 14.0 0.1 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Interferon PF00143.14 AMD20766.1 - 0.0078 16.0 0.4 0.018 14.9 0.3 1.6 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF357 PF04010.8 AMD20766.1 - 0.029 14.0 0.1 0.079 12.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF357) TPR_7 PF13176.1 AMD20766.1 - 0.037 13.8 0.1 1.3 9.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 AMD20766.1 - 0.065 12.8 0.6 0.2 11.2 0.1 2.0 2 0 0 2 2 2 0 TPR repeat DUF1955 PF09205.5 AMD20766.1 - 0.091 12.2 0.6 0.22 11.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1955) MtrA PF04208.9 AMD20766.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A DUF1423 PF07227.6 AMD20767.1 - 0.00059 18.6 4.4 0.00092 17.9 3.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1423) Filament PF00038.16 AMD20767.1 - 0.27 10.6 20.5 1.5 8.1 2.8 2.2 1 1 1 2 2 2 0 Intermediate filament protein DivIC PF04977.10 AMD20767.1 - 0.91 9.0 18.0 2.6 7.5 0.2 4.8 4 1 1 5 5 5 0 Septum formation initiator Laminin_II PF06009.7 AMD20767.1 - 1.5 8.5 12.8 1.7 8.3 4.4 3.1 1 1 1 3 3 3 0 Laminin Domain II DUF948 PF06103.6 AMD20767.1 - 2.9 7.7 16.9 0.63 9.9 0.1 3.5 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4164 PF13747.1 AMD20767.1 - 5 7.3 15.6 17 5.6 0.9 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF1664 PF07889.7 AMD20767.1 - 5.1 6.9 11.7 1.2 8.9 2.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) bZIP_Maf PF03131.12 AMD20767.1 - 7.9 6.8 12.0 9.2 6.6 0.1 3.6 3 1 0 3 3 3 0 bZIP Maf transcription factor cwf21 PF08312.7 AMD20769.1 - 8e-14 51.2 3.8 1.3e-13 50.5 2.6 1.3 1 0 0 1 1 1 1 cwf21 domain Trans_reg_C PF00486.23 AMD20769.1 - 0.018 14.9 0.9 0.19 11.6 0.5 2.4 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal Phage_Gp23 PF10669.4 AMD20769.1 - 1.6 8.8 6.5 0.38 10.8 2.0 1.7 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) OrfB_Zn_ribbon PF07282.6 AMD20770.1 - 3.8e-17 61.7 1.7 8e-17 60.6 1.2 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain HTH_OrfB_IS605 PF12323.3 AMD20770.1 - 7e-08 31.6 0.2 1.8e-07 30.3 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain MIP PF00230.15 AMD20772.1 - 1.3e-40 139.2 21.8 2e-40 138.6 15.1 1.2 1 0 0 1 1 1 1 Major intrinsic protein Glyco_transf_15 PF01793.11 AMD20773.1 - 6.7e-145 482.1 13.5 8.1e-145 481.8 9.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TPR_11 PF13414.1 AMD20774.1 - 5.3e-19 67.6 7.0 6.2e-14 51.3 1.3 2.7 1 1 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 AMD20774.1 - 1.9e-13 49.1 1.8 0.003 17.3 0.0 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 AMD20774.1 - 1.1e-12 46.9 4.8 0.00014 21.2 0.3 3.6 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 AMD20774.1 - 6.2e-08 33.1 0.0 0.00016 22.2 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 AMD20774.1 - 1.1e-06 28.6 1.6 2.9e-06 27.3 0.6 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 AMD20774.1 - 2.9e-06 27.0 2.8 0.0095 16.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 AMD20774.1 - 4.6e-06 26.8 0.2 0.00039 20.7 0.0 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 AMD20774.1 - 1.6e-05 24.7 0.2 0.011 15.5 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20774.1 - 0.00011 21.7 5.1 0.19 11.5 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 AMD20774.1 - 0.00027 21.2 0.2 2.8 8.8 0.0 4.2 2 1 2 4 4 3 1 Tetratricopeptide repeat DUF3808 PF10300.4 AMD20774.1 - 0.0011 17.6 0.8 0.0014 17.2 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) Nro1 PF12753.2 AMD20774.1 - 0.0053 15.7 3.8 0.0086 15.0 2.6 1.2 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 THOC7 PF05615.8 AMD20774.1 - 0.0086 16.3 5.9 0.015 15.5 3.4 1.9 1 1 1 2 2 2 1 Tho complex subunit 7 TPR_6 PF13174.1 AMD20774.1 - 0.032 14.6 3.1 4.3 8.0 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 AMD20774.1 - 0.17 11.8 4.3 17 5.3 0.1 3.4 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat INCENP_ARK-bind PF03941.10 AMD20775.1 - 6.7e-20 70.6 0.6 6.7e-20 70.6 0.4 2.1 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region zf-CCCH PF00642.19 AMD20777.1 - 1.1e-10 40.9 12.2 1.2e-05 24.8 1.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 AMD20777.1 - 0.62 10.1 15.1 0.12 12.4 3.1 2.8 2 1 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type LRR_4 PF12799.2 AMD20778.1 - 6.2e-07 28.8 0.0 0.047 13.3 0.1 3.6 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 AMD20778.1 - 9.4e-05 22.0 1.0 0.58 10.3 0.0 4.9 4 1 0 4 4 4 1 Leucine Rich repeat LRR_7 PF13504.1 AMD20778.1 - 0.00029 20.5 1.0 6.8 7.3 0.4 5.2 5 0 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.28 AMD20778.1 - 1 9.6 4.6 31 5.1 0.0 4.1 3 1 0 3 3 3 0 Leucine Rich Repeat Lge1 PF11488.3 AMD20779.1 - 5.5e-18 64.9 1.3 5.5e-18 64.9 0.9 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein LGE1 Mucin PF01456.12 AMD20779.1 - 1.3 8.7 8.5 2.3 7.9 5.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein adh_short PF00106.20 AMD20780.1 - 1.4e-24 86.9 0.0 2.2e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AMD20780.1 - 3e-09 36.9 0.0 4.5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AMD20780.1 - 5e-09 36.0 0.0 8.1e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 AMD20780.1 - 0.0013 18.7 0.0 0.0052 16.7 0.0 1.9 2 0 0 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 AMD20780.1 - 0.035 13.5 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 AMD20780.1 - 0.1 11.4 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Dus PF01207.12 AMD20780.1 - 0.14 10.9 0.1 12 4.5 0.0 2.3 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) Pkinase PF00069.20 AMD20781.1 - 2.9e-74 249.5 0.0 3.2e-74 249.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20781.1 - 1.4e-34 119.3 0.0 1.7e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20781.1 - 4.5e-07 29.1 0.0 1e-06 27.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 AMD20781.1 - 0.0079 15.9 0.3 0.1 12.3 0.1 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 AMD20781.1 - 0.028 13.4 0.2 0.099 11.6 0.0 1.9 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 AMD20781.1 - 0.067 12.0 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pox_ser-thr_kin PF05445.6 AMD20781.1 - 0.46 9.2 2.6 5 5.7 0.1 2.1 1 1 1 2 2 2 0 Poxvirus serine/threonine protein kinase DUF2401 PF10287.4 AMD20782.1 - 3.9e-95 317.8 0.6 5.8e-95 317.2 0.4 1.3 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 AMD20782.1 - 4.5e-26 90.7 0.1 1.1e-25 89.5 0.1 1.7 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) RR_TM4-6 PF06459.7 AMD20782.1 - 1.8 8.4 6.8 2.8 7.7 4.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RAMP4 PF06624.7 AMD20783.1 - 0.0053 16.2 0.0 0.0062 16.0 0.0 1.2 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Exo5 PF09810.4 AMD20784.1 - 1.3e-21 77.1 0.0 6.8e-21 74.8 0.0 1.9 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease Glutaredoxin PF00462.19 AMD20785.1 - 5.4e-17 61.5 0.0 8.4e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin AMP-binding PF00501.23 AMD20786.1 - 2.1e-75 253.6 0.0 2.7e-75 253.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FTR1 PF03239.9 AMD20787.1 - 2e-94 316.0 9.1 2.4e-94 315.7 6.3 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family CorA PF01544.13 AMD20788.1 - 0.00091 18.3 7.6 0.0026 16.8 5.3 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Glyco_transf_15 PF01793.11 AMD20789.1 - 6.9e-137 455.8 12.1 8.8e-137 455.4 8.4 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase UPF0118 PF01594.11 AMD20789.1 - 0.11 11.4 0.0 0.24 10.3 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function DUF20 Abhydrolase_6 PF12697.2 AMD20790.1 - 1.3e-15 57.8 0.0 2.2e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AMD20790.1 - 6.6e-08 32.4 0.0 1.5e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 AMD20790.1 - 0.0093 15.7 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase NIF PF03031.13 AMD20791.1 - 2e-40 138.0 0.0 3.5e-40 137.2 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pro_isomerase PF00160.16 AMD20792.1 - 5e-08 33.3 0.0 5.1e-07 30.0 0.0 2.2 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD VPS28 PF03997.7 AMD20793.1 - 1.3e-68 230.3 3.8 1.5e-68 230.1 2.7 1.0 1 0 0 1 1 1 1 VPS28 protein DUF1759 PF03564.10 AMD20793.1 - 0.04 13.7 5.1 0.49 10.1 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1759) DUF3890 PF13029.1 AMD20793.1 - 0.29 11.2 6.8 2.4 8.2 0.3 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3890) Arrestin_C PF02752.17 AMD20794.1 - 0.00059 19.9 6.6 0.0049 16.9 0.3 2.4 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain MCM PF00493.18 AMD20795.1 - 7.3e-136 452.3 0.0 1e-135 451.8 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 AMD20795.1 - 5.2e-25 88.2 0.9 1.8e-24 86.5 0.2 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 AMD20795.1 - 1.3e-07 31.0 0.1 4.3e-05 22.7 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 AMD20795.1 - 5.9e-07 29.2 0.0 2.1e-06 27.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_2 PF13335.1 AMD20795.1 - 0.00097 19.4 0.4 0.0043 17.4 0.2 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 AMD20795.1 - 0.022 14.3 0.0 0.074 12.6 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-HYPF PF07503.7 AMD20795.1 - 0.67 9.4 3.1 0.26 10.7 0.2 1.8 2 0 0 2 2 2 0 HypF finger COX7C PF02935.11 AMD20796.1 - 0.089 12.6 0.2 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc DUF2577 PF10844.3 AMD20798.1 - 0.053 13.5 0.1 0.074 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2577) DUF2708 PF10917.3 AMD20798.1 - 0.37 10.6 1.6 1.8 8.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2708) polyprenyl_synt PF00348.12 AMD20799.1 - 1.1e-42 145.7 0.0 1.4e-42 145.3 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase VPS9 PF02204.13 AMD20800.1 - 3e-17 62.5 1.0 6.1e-17 61.5 0.7 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SH3_1 PF00018.23 AMD20802.1 - 8.5e-22 76.2 0.0 6.7e-11 41.4 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 AMD20802.1 - 1.5e-14 53.3 0.3 6.5e-10 38.4 0.1 2.7 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.19 AMD20802.1 - 5.7e-14 51.8 0.0 1.2e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.12 AMD20802.1 - 1.2e-06 27.9 0.1 1.6e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain PB1 PF00564.19 AMD20802.1 - 0.00024 20.6 0.0 0.00075 19.1 0.0 1.9 2 0 0 2 2 2 1 PB1 domain IL3 PF02059.10 AMD20802.1 - 0.049 13.6 0.4 0.11 12.4 0.3 1.5 1 0 0 1 1 1 0 Interleukin-3 UCH PF00443.24 AMD20803.1 - 9e-41 139.7 8.9 5.8e-38 130.5 4.6 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase AAA PF00004.24 AMD20804.1 - 4.4e-39 133.7 0.0 1.4e-38 132.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD20804.1 - 1.3e-05 24.3 0.0 2.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 AMD20804.1 - 2.7e-05 24.3 0.1 0.0012 19.0 0.1 2.6 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 AMD20804.1 - 0.00013 20.7 0.0 0.00024 19.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_2 PF07724.9 AMD20804.1 - 0.00049 20.0 0.0 0.0024 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 AMD20804.1 - 0.0012 19.6 0.0 0.0046 17.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 AMD20804.1 - 0.0013 18.1 0.0 0.0026 17.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 AMD20804.1 - 0.0021 18.3 0.0 0.013 15.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 AMD20804.1 - 0.0026 17.4 2.6 0.59 9.7 0.0 3.7 3 1 1 4 4 4 1 Archaeal ATPase AAA_5 PF07728.9 AMD20804.1 - 0.0026 17.4 0.0 0.011 15.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 AMD20804.1 - 0.0033 16.6 0.1 0.0075 15.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 AMD20804.1 - 0.0045 16.6 0.2 0.018 14.7 0.1 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 AMD20804.1 - 0.0055 16.7 0.1 0.066 13.1 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 AMD20804.1 - 0.0058 16.0 0.3 0.11 11.8 0.0 2.5 1 1 2 3 3 3 1 AAA domain AAA_33 PF13671.1 AMD20804.1 - 0.0093 15.8 0.0 0.026 14.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain Vps4_C PF09336.5 AMD20804.1 - 0.0098 15.7 0.0 0.029 14.2 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_14 PF13173.1 AMD20804.1 - 0.017 15.0 0.0 0.041 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Chromo PF00385.19 AMD20804.1 - 0.027 14.1 0.1 0.073 12.7 0.0 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain DUF815 PF05673.8 AMD20804.1 - 0.028 13.3 0.0 0.05 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 AMD20804.1 - 0.096 12.1 0.0 0.25 10.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 AMD20804.1 - 0.1 12.5 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain GCR1_C PF12550.3 AMD20805.1 - 1e-24 86.1 2.1 1e-24 86.1 1.5 1.9 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes WD40 PF00400.27 AMD20806.1 - 1.4e-61 202.3 17.9 7.3e-12 44.6 0.0 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 AMD20806.1 - 1.8e-50 170.6 2.1 3.3e-50 169.8 1.5 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit LisH PF08513.6 AMD20806.1 - 1.8e-06 27.4 0.1 3.8e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 LisH Nup160 PF11715.3 AMD20806.1 - 0.0023 16.1 1.5 1.1 7.3 0.0 3.2 2 2 2 4 4 4 2 Nucleoporin Nup120/160 Hira PF07569.6 AMD20806.1 - 0.068 12.3 0.0 5.2 6.2 0.0 2.7 2 1 1 3 3 3 0 TUP1-like enhancer of split GPI2 PF06432.6 AMD20807.1 - 9.4e-60 202.3 27.6 6.5e-59 199.5 19.1 1.8 1 1 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase UPF0060 PF02694.10 AMD20807.1 - 1.1 9.3 8.0 0.23 11.4 0.2 2.6 1 1 1 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family PGI PF00342.14 AMD20809.1 - 1.1e-225 749.6 4.0 1.4e-225 749.3 2.8 1.1 1 0 0 1 1 1 1 Phosphoglucose isomerase SAP30_Sin3_bdg PF13867.1 AMD20809.1 - 0.021 14.7 0.3 3.1 7.7 0.0 3.1 3 0 0 3 3 3 0 Sin3 binding region of histone deacetylase complex subunit SAP30 CAF1C_H4-bd PF12265.3 AMD20810.1 - 1.5e-17 63.2 1.6 4.1e-17 61.8 1.1 1.8 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 AMD20810.1 - 7.2e-13 47.8 12.5 0.0009 19.0 1.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat CAT PF00302.13 AMD20810.1 - 0.029 13.9 0.8 0.067 12.8 0.6 1.5 1 0 0 1 1 1 0 Chloramphenicol acetyltransferase Yopt PF09467.5 AMD20810.1 - 0.14 12.0 0.1 0.34 10.7 0.1 1.7 1 0 0 1 1 1 0 Hypothetical protein Yopt Mt_ATP-synt_B PF05405.9 AMD20811.1 - 2.5e-51 173.3 9.4 3e-51 173.1 6.5 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DASH_Duo1 PF08651.5 AMD20811.1 - 0.42 10.2 3.4 6.7 6.3 0.3 2.7 1 1 1 2 2 2 0 DASH complex subunit Duo1 DivIC PF04977.10 AMD20811.1 - 0.57 9.6 6.8 0.12 11.9 0.7 2.5 2 1 0 2 2 2 0 Septum formation initiator DUF724 PF05266.9 AMD20811.1 - 1.1 8.8 8.1 9.8 5.7 5.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Med8 PF10232.4 AMD20812.1 - 6.8e-42 143.5 0.1 9.7e-42 143.0 0.1 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 G10 PF01125.12 AMD20812.1 - 0.016 14.7 0.1 0.043 13.3 0.1 1.6 2 0 0 2 2 2 0 G10 protein Mito_carr PF00153.22 AMD20813.1 - 8.3e-79 259.4 0.7 3.1e-27 94.0 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.11 AMD20813.1 - 0.034 14.0 0.0 0.42 10.5 0.0 2.6 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Ribosomal_L21e PF01157.13 AMD20814.1 - 3.9e-44 148.4 5.2 6.5e-44 147.7 3.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e LRS4 PF10422.4 AMD20814.1 - 0.005 16.2 0.0 0.006 15.9 0.0 1.1 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 Ribosomal_S4 PF00163.14 AMD20815.1 - 3.7e-27 94.5 1.8 5.8e-27 93.9 1.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 AMD20815.1 - 3e-12 45.7 0.3 1.1e-11 44.0 0.2 1.9 1 0 0 1 1 1 1 S4 domain DUF3535 PF12054.3 AMD20816.1 - 1.8e-145 484.9 4.0 1.4e-144 481.9 0.6 3.4 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 AMD20816.1 - 6e-79 264.9 0.0 1e-78 264.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.17 AMD20816.1 - 2.8e-15 54.9 1.2 0.37 11.0 0.0 9.1 9 0 0 9 9 9 4 HEAT repeat Helicase_C PF00271.26 AMD20816.1 - 2.8e-13 49.5 0.0 7.3e-13 48.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_2 PF13646.1 AMD20816.1 - 8.2e-07 29.2 4.1 1.3 9.3 0.0 6.9 6 3 1 7 7 7 3 HEAT repeats HEAT_EZ PF13513.1 AMD20816.1 - 1.9e-06 28.1 8.2 1.2 9.7 0.0 8.0 8 1 1 9 9 9 2 HEAT-like repeat cwf18 PF08315.7 AMD20817.1 - 0.014 15.8 4.0 0.022 15.2 2.8 1.5 1 1 0 1 1 1 0 cwf18 pre-mRNA splicing factor Asp-B-Hydro_N PF05279.6 AMD20817.1 - 0.046 13.5 0.1 0.051 13.4 0.1 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Med28 PF11594.3 AMD20817.1 - 0.082 13.1 0.7 0.096 12.9 0.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 28 UPF0016 PF01169.14 AMD20818.1 - 1.5e-42 143.5 23.0 7e-22 77.3 4.2 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 LysE PF01810.13 AMD20818.1 - 0.0035 16.6 12.2 0.013 14.7 1.1 2.5 2 1 0 2 2 2 2 LysE type translocator DUF308 PF03729.8 AMD20818.1 - 0.27 11.2 10.0 3.3 7.7 0.3 3.0 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) DUF4131 PF13567.1 AMD20818.1 - 1 8.7 5.0 1.8 7.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) TerC PF03741.11 AMD20818.1 - 3.8 6.9 12.2 1.6 8.1 2.2 2.5 2 1 0 2 2 2 0 Integral membrane protein TerC family AAA PF00004.24 AMD20819.1 - 2.7e-32 111.7 0.0 6.2e-32 110.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 AMD20819.1 - 2.3e-08 34.2 0.1 1.4e-07 31.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD20819.1 - 1e-07 32.7 0.1 6.5e-07 30.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 AMD20819.1 - 5.5e-07 29.7 0.1 1.2e-05 25.3 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.1 AMD20819.1 - 8.6e-07 28.7 0.0 1.7e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD20819.1 - 2.6e-06 27.0 0.1 5.8e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 AMD20819.1 - 5.9e-06 26.6 0.0 2.2e-05 24.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 AMD20819.1 - 0.00011 21.2 0.0 0.00033 19.6 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_24 PF13479.1 AMD20819.1 - 0.00017 21.2 0.0 0.00035 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AMD20819.1 - 0.00028 20.7 0.0 0.00071 19.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 AMD20819.1 - 0.00029 20.5 0.4 0.003 17.2 0.3 2.5 1 1 0 1 1 1 1 NACHT domain RNA_helicase PF00910.17 AMD20819.1 - 0.00037 20.6 0.0 0.0024 18.0 0.0 2.4 2 0 0 2 2 1 1 RNA helicase RuvB_N PF05496.7 AMD20819.1 - 0.0005 19.1 0.0 0.00084 18.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 AMD20819.1 - 0.00077 19.1 0.2 0.012 15.3 0.1 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_23 PF13476.1 AMD20819.1 - 0.00078 19.8 0.1 0.00078 19.8 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.1 AMD20819.1 - 0.00086 19.2 0.1 0.0027 17.5 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AMD20819.1 - 0.0013 18.1 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 AMD20819.1 - 0.0015 18.2 0.0 0.0054 16.4 0.0 1.9 1 1 0 1 1 1 1 Archaeal ATPase Sigma54_activat PF00158.21 AMD20819.1 - 0.0016 17.9 0.0 0.0031 16.9 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.1 AMD20819.1 - 0.0021 17.6 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 AMD20819.1 - 0.0031 17.7 0.2 0.0092 16.2 0.0 1.9 2 1 1 3 3 1 1 ABC transporter DUF2075 PF09848.4 AMD20819.1 - 0.0034 16.4 0.0 0.0061 15.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_10 PF12846.2 AMD20819.1 - 0.0038 16.6 0.1 3.1 7.1 0.0 2.5 2 1 0 2 2 2 1 AAA-like domain IstB_IS21 PF01695.12 AMD20819.1 - 0.008 15.6 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein cobW PF02492.14 AMD20819.1 - 0.0087 15.5 1.2 1.1 8.7 0.0 2.8 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_31 PF13614.1 AMD20819.1 - 0.0096 15.8 1.3 0.29 11.0 0.0 3.0 2 1 1 3 3 3 1 AAA domain NTPase_1 PF03266.10 AMD20819.1 - 0.0098 15.6 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 1 NTPase AAA_28 PF13521.1 AMD20819.1 - 0.0099 15.8 0.2 0.029 14.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 AMD20819.1 - 0.014 14.6 0.1 0.1 11.7 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.17 AMD20819.1 - 0.017 13.9 0.0 0.051 12.4 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.7 AMD20819.1 - 0.018 14.1 0.0 0.093 11.8 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin Sigma54_activ_2 PF14532.1 AMD20819.1 - 0.019 15.0 0.0 0.052 13.5 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Viral_helicase1 PF01443.13 AMD20819.1 - 0.023 14.2 0.0 0.058 12.9 0.0 1.8 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase UPF0079 PF02367.12 AMD20819.1 - 0.025 14.2 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 MobB PF03205.9 AMD20819.1 - 0.025 14.2 0.0 0.066 12.9 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B KaiC PF06745.8 AMD20819.1 - 0.026 13.6 0.1 0.076 12.1 0.0 1.8 2 0 0 2 2 2 0 KaiC KTI12 PF08433.5 AMD20819.1 - 0.042 13.0 0.0 0.091 11.9 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ResIII PF04851.10 AMD20819.1 - 0.045 13.5 1.5 0.12 12.1 0.0 2.4 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit TrwB_AAD_bind PF10412.4 AMD20819.1 - 0.073 11.6 0.1 0.29 9.6 0.0 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.13 AMD20819.1 - 0.15 11.5 0.1 0.25 10.8 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family tRNA_int_end_N2 PF12928.2 AMD20820.1 - 2.8e-20 71.5 0.0 8.7e-20 69.9 0.0 1.8 2 0 0 2 2 2 1 tRNA-splicing endonuclease subunit sen54 N-term EF-hand_1 PF00036.27 AMD20820.1 - 0.03 13.6 0.2 0.64 9.4 0.0 2.7 2 0 0 2 2 2 0 EF hand BRO1 PF03097.13 AMD20821.1 - 2.4e-84 283.2 5.8 2.4e-84 283.2 4.0 2.1 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 AMD20821.1 - 4e-40 137.6 15.9 1.5e-39 135.7 11.0 1.9 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV ABC2_membrane_3 PF12698.2 AMD20821.1 - 0.015 14.3 0.4 0.034 13.1 0.3 1.6 1 0 0 1 1 1 0 ABC-2 family transporter protein MBA1 PF07961.6 AMD20822.1 - 3.4e-93 310.8 1.7 4.1e-93 310.5 1.2 1.1 1 0 0 1 1 1 1 MBA1-like protein Sec16_C PF12931.2 AMD20823.1 - 3.2e-75 253.5 0.0 6.2e-75 252.5 0.0 1.5 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 AMD20823.1 - 7.3e-17 61.4 0.2 7.3e-17 61.4 0.1 2.5 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region Radical_SAM PF04055.16 AMD20824.1 - 2e-17 63.8 0.4 6.5e-17 62.1 0.0 2.0 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 AMD20824.1 - 6.6e-12 45.3 0.0 2.1e-11 43.6 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 AMD20824.1 - 0.053 13.6 0.0 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 AMD20824.1 - 0.098 12.8 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ceramidase PF05875.7 AMD20825.1 - 1.5e-94 315.9 17.6 1.8e-94 315.7 12.2 1.0 1 0 0 1 1 1 1 Ceramidase Bac_rhodopsin PF01036.13 AMD20825.1 - 0.00018 20.9 2.5 0.00018 20.9 1.7 1.7 2 0 0 2 2 2 1 Bacteriorhodopsin-like protein Transposase_28 PF04195.7 AMD20825.1 - 0.16 11.2 1.6 0.33 10.2 1.1 1.5 1 0 0 1 1 1 0 Putative gypsy type transposon DUF3753 PF12575.3 AMD20825.1 - 0.4 10.5 0.1 0.4 10.5 0.0 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF3753) DUF3816 PF12822.2 AMD20825.1 - 2.2 8.1 14.4 3.8 7.3 3.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3816) SRF-TF PF00319.13 AMD20826.1 - 2.3e-23 81.1 0.3 8.6e-23 79.3 0.0 2.1 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ribosomal_S6e PF01092.14 AMD20827.1 - 3.2e-64 214.2 1.4 7.9e-64 213.0 1.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S6e DUF2992 PF11208.3 AMD20827.1 - 0.19 11.6 8.8 0.28 11.0 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Pyr_redox_2 PF07992.9 AMD20828.1 - 5.8e-43 147.1 0.0 1.3e-42 145.9 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 AMD20828.1 - 9.7e-36 122.1 0.2 9.5e-35 118.9 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 AMD20828.1 - 7.7e-19 67.8 2.6 9.9e-18 64.3 0.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 AMD20828.1 - 6.1e-11 42.7 0.1 2.4e-07 31.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 AMD20828.1 - 6.9e-09 34.6 1.4 0.0038 15.7 0.0 3.1 3 0 0 3 3 3 3 HI0933-like protein FAD_oxidored PF12831.2 AMD20828.1 - 9.9e-05 21.5 0.0 0.00016 20.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.16 AMD20828.1 - 0.00018 21.1 0.1 0.23 11.0 0.0 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.1 AMD20828.1 - 0.00062 18.7 0.0 0.013 14.4 0.0 2.2 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.17 AMD20828.1 - 0.0017 17.2 3.7 0.0033 16.3 1.7 2.2 2 1 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.19 AMD20828.1 - 0.0027 16.6 2.2 0.0071 15.2 0.2 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AMD20828.1 - 0.0033 16.3 6.3 0.045 12.5 1.5 2.8 3 0 0 3 3 3 1 FAD binding domain 2-Hacid_dh_C PF02826.14 AMD20828.1 - 0.0046 16.1 1.2 0.28 10.3 0.0 2.9 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 AMD20828.1 - 0.035 13.7 0.0 0.035 13.7 0.0 2.3 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.14 AMD20828.1 - 0.076 12.0 1.4 7.5 5.4 0.2 2.3 2 0 0 2 2 2 0 FAD binding domain NAD_Gly3P_dh_N PF01210.18 AMD20828.1 - 0.083 12.6 0.8 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Thi4 PF01946.12 AMD20828.1 - 0.085 11.9 0.6 0.26 10.3 0.2 2.0 2 0 0 2 2 2 0 Thi4 family MFS_1 PF07690.11 AMD20829.1 - 4.9e-43 147.2 22.3 4.9e-43 147.2 15.4 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 AMD20829.1 - 8.9e-17 60.7 23.5 1.9e-16 59.7 1.0 3.5 3 1 0 3 3 3 3 Sugar (and other) transporter Peptidase_M50 PF02163.17 AMD20829.1 - 0.025 13.5 0.1 0.025 13.5 0.1 2.0 2 0 0 2 2 2 0 Peptidase family M50 Peptidase_S64 PF08192.6 AMD20829.1 - 1.7 6.8 10.9 2.4 6.4 7.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 NOGCT PF08155.6 AMD20830.1 - 2.7e-27 94.2 2.2 4.5e-27 93.5 0.4 2.2 1 1 1 2 2 2 1 NOGCT (NUC087) domain NOG1 PF06858.9 AMD20830.1 - 2.8e-26 91.1 0.4 6.5e-26 89.9 0.3 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.18 AMD20830.1 - 8.7e-17 61.1 0.0 2.6e-16 59.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD20830.1 - 9e-09 34.7 0.1 2.1e-08 33.6 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 AMD20830.1 - 0.00019 21.8 0.1 0.0013 19.2 0.0 2.4 1 1 1 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 AMD20830.1 - 0.00083 18.5 0.3 0.0015 17.7 0.2 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.18 AMD20830.1 - 0.011 15.5 1.0 2.4 7.9 0.0 3.1 2 1 1 3 3 3 0 Dynamin family MobB PF03205.9 AMD20830.1 - 0.059 13.0 0.0 0.31 10.7 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 AMD20830.1 - 0.096 12.9 3.6 1.7 8.9 0.0 3.4 2 1 1 3 3 3 0 AAA domain Sec62 PF03839.11 AMD20831.1 - 4.3e-59 199.6 0.5 5e-59 199.4 0.3 1.0 1 0 0 1 1 1 1 Translocation protein Sec62 Dynamin_N PF00350.18 AMD20832.1 - 4.1e-18 65.7 0.3 1.1e-17 64.3 0.2 1.8 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 AMD20832.1 - 3.1e-10 40.0 0.1 1.9e-09 37.5 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD20832.1 - 3.3e-09 36.4 2.9 1e-07 31.5 2.1 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 AMD20832.1 - 0.0009 18.7 0.5 0.99 8.8 0.2 2.8 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.1 AMD20832.1 - 0.0061 16.8 1.9 0.15 12.4 0.2 3.3 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD20832.1 - 0.009 16.8 0.0 0.57 11.0 0.0 3.3 2 1 0 2 2 2 1 AAA domain Miro PF08477.8 AMD20832.1 - 0.026 14.9 1.6 0.48 10.9 0.2 3.1 2 1 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 AMD20832.1 - 0.03 13.8 0.0 0.065 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.13 AMD20832.1 - 0.04 13.1 1.3 7.7 5.7 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B cobW PF02492.14 AMD20832.1 - 0.093 12.1 8.0 0.082 12.3 1.7 3.0 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Abhydrolase_1 PF00561.15 AMD20833.1 - 4.4e-16 59.1 0.0 1e-15 57.9 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 AMD20833.1 - 2.5e-12 47.2 0.0 4.5e-12 46.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AMD20833.1 - 3.6e-05 23.5 0.0 0.00058 19.6 0.0 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Rad4 PF03835.10 AMD20834.1 - 3.2e-14 52.5 0.4 9.1e-14 51.0 0.3 1.7 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Transglut_core PF01841.14 AMD20834.1 - 5.9e-10 39.3 0.3 1.2e-09 38.3 0.2 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Ogr_Delta PF04606.7 AMD20834.1 - 0.034 13.7 2.5 0.1 12.2 1.8 1.8 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger IBR PF01485.16 AMD20834.1 - 0.07 13.0 1.8 0.31 10.9 1.2 2.1 1 0 0 1 1 1 0 IBR domain DUF950 PF06106.6 AMD20834.1 - 0.43 10.6 4.2 0.56 10.3 0.7 2.4 2 1 0 2 2 2 0 Staphylococcus protein of unknown function (DUF950) DUF1273 PF06908.6 AMD20834.1 - 1.2 8.7 5.2 2.1 7.9 0.2 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF1273) zf-B_box PF00643.19 AMD20834.1 - 1.3 9.0 5.4 0.78 9.6 0.4 2.7 3 0 0 3 3 3 0 B-box zinc finger Zn_Tnp_IS1595 PF12760.2 AMD20834.1 - 4.2 7.2 7.6 10 6.0 4.1 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain PrgI PF12666.2 AMD20835.1 - 0.12 12.4 0.9 0.13 12.4 0.6 1.1 1 0 0 1 1 1 0 PrgI family protein 2TM PF13239.1 AMD20835.1 - 0.39 10.8 4.6 0.49 10.4 3.2 1.2 1 0 0 1 1 1 0 2TM domain TrbE PF11100.3 AMD20835.1 - 0.55 10.1 4.9 0.9 9.4 1.3 2.0 2 0 0 2 2 2 0 Conjugal transfer protein TrbE tRNA-synt_1b PF00579.20 AMD20836.1 - 8.1e-73 245.0 0.0 1e-72 244.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Romo1 PF10247.4 AMD20837.1 - 9.9e-29 99.3 7.8 1.2e-28 99.0 5.4 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Ku_PK_bind PF08785.6 AMD20838.1 - 0.1 12.4 0.6 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Ku C terminal domain like Microtub_assoc PF07989.6 AMD20838.1 - 0.2 11.4 4.5 6.8 6.6 0.6 2.5 2 0 0 2 2 2 0 Microtubule associated WD40 PF00400.27 AMD20839.1 - 4.2e-06 26.4 2.5 0.0013 18.5 0.0 4.2 4 1 0 4 4 4 2 WD domain, G-beta repeat Lactonase PF10282.4 AMD20839.1 - 0.008 15.2 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller PAXNEB PF05625.6 AMD20840.1 - 1.5e-104 349.7 0.6 1.8e-104 349.4 0.4 1.1 1 0 0 1 1 1 1 PAXNEB protein dsrm PF00035.20 AMD20841.1 - 9.3e-08 32.5 0.0 1.8e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.21 AMD20841.1 - 1.6e-05 25.3 0.0 3.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain PUL PF08324.6 AMD20841.1 - 0.06 12.1 0.0 0.093 11.5 0.0 1.2 1 0 0 1 1 1 0 PUL domain OrfB_IS605 PF01385.14 AMD20842.1 - 0.16 11.3 0.1 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Probable transposase Pex2_Pex12 PF04757.9 AMD20843.1 - 1.1e-32 113.3 6.6 1.3e-32 113.0 4.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 AMD20843.1 - 1.9e-06 27.7 1.8 3.6e-06 26.9 1.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD20843.1 - 6.1e-05 22.5 0.6 0.00011 21.8 0.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD20843.1 - 0.05 13.2 0.7 0.089 12.4 0.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD20843.1 - 0.13 12.0 1.5 0.3 10.9 1.0 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.1 AMD20843.1 - 0.15 11.9 4.1 0.31 10.9 2.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING F_bP_aldolase PF01116.15 AMD20844.1 - 1.6e-94 316.2 0.0 1.8e-94 316.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II DUF89 PF01937.14 AMD20845.1 - 2.2e-104 349.0 0.2 2.5e-104 348.9 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DWNN PF08783.6 AMD20846.1 - 1e-31 108.7 1.4 1.3e-31 108.3 0.1 1.8 2 0 0 2 2 2 1 DWNN domain U-box PF04564.10 AMD20846.1 - 1.2e-05 25.1 0.0 0.00017 21.4 0.0 2.4 2 0 0 2 2 2 1 U-box domain zf-CCHC_2 PF13696.1 AMD20846.1 - 0.00076 18.9 4.1 0.0017 17.7 2.9 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 AMD20846.1 - 0.0016 18.2 4.1 0.0032 17.3 2.8 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-Nse PF11789.3 AMD20846.1 - 0.0032 16.9 0.3 0.0076 15.7 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Rubredoxin PF00301.15 AMD20846.1 - 0.0032 17.2 3.9 1.1 9.2 0.0 3.1 3 0 0 3 3 3 2 Rubredoxin zf-CCHC_3 PF13917.1 AMD20846.1 - 0.014 15.1 0.1 0.026 14.2 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle Telomere_Sde2_2 PF13297.1 AMD20846.1 - 0.026 13.7 0.0 0.061 12.6 0.0 1.6 1 0 0 1 1 1 0 Telomere stability C-terminal TFIIA_gamma_C PF02751.9 AMD20847.1 - 3.1e-26 90.9 2.2 4.6e-26 90.3 1.6 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.11 AMD20847.1 - 2.5e-25 87.8 0.3 3.4e-25 87.3 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TAP42 PF04177.7 AMD20848.1 - 2.2e-92 309.5 16.1 2.5e-92 309.4 11.2 1.0 1 0 0 1 1 1 1 TAP42-like family Nup160 PF11715.3 AMD20849.1 - 9.8e-11 40.4 1.2 5.2e-10 38.0 0.8 1.9 2 1 0 2 2 2 1 Nucleoporin Nup120/160 Striatin PF08232.7 AMD20850.1 - 4.5e-27 95.0 5.3 3.2e-24 85.7 1.1 2.4 1 1 1 2 2 2 2 Striatin family HAP1_N PF04849.8 AMD20850.1 - 0.021 13.7 1.7 0.042 12.7 1.2 1.5 1 0 0 1 1 1 0 HAP1 N-terminal conserved region TSC22 PF01166.13 AMD20850.1 - 0.082 12.8 0.5 0.23 11.4 0.4 1.8 1 0 0 1 1 1 0 TSC-22/dip/bun family Herpes_BLRF2 PF05812.7 AMD20850.1 - 0.11 12.3 1.1 0.41 10.4 0.4 2.1 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein Mto2_bdg PF12808.2 AMD20850.1 - 0.11 12.5 1.9 0.27 11.3 1.3 1.5 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region bZIP_1 PF00170.16 AMD20850.1 - 0.12 12.3 0.7 0.61 10.0 0.3 2.1 2 0 0 2 2 2 0 bZIP transcription factor DERM PF14704.1 AMD20850.1 - 0.13 12.1 0.0 16 5.4 0.0 2.3 2 0 0 2 2 2 0 Dermatopontin TCTP PF00838.12 AMD20851.1 - 3.8e-74 248.1 1.8 4.3e-74 247.9 1.2 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein NAGidase PF07555.8 AMD20851.1 - 0.024 13.5 0.1 0.027 13.3 0.1 1.1 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase adh_short PF00106.20 AMD20852.1 - 1.7e-11 44.3 0.1 4.6e-06 26.6 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase DUF3815 PF12821.2 AMD20852.1 - 0.015 15.2 0.4 0.034 14.0 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3815) CUE PF02845.11 AMD20853.1 - 0.061 12.8 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 CUE domain UPF0203 PF05254.7 AMD20854.1 - 3e-30 103.8 4.4 3.6e-30 103.6 3.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.11 AMD20854.1 - 0.00054 19.8 4.1 0.0016 18.3 2.9 1.7 1 1 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.5 AMD20854.1 - 0.00055 19.6 2.6 0.072 12.8 0.1 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.12 AMD20854.1 - 0.11 12.5 6.0 0.29 11.1 0.4 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Mvb12 PF09452.5 AMD20854.1 - 0.54 10.4 2.4 0.86 9.8 0.3 2.0 1 1 1 2 2 2 0 ESCRT-I subunit Mvb12 DASH_Ask1 PF08655.5 AMD20855.1 - 2.3e-29 101.0 0.4 6.2e-29 99.6 0.3 1.8 1 0 0 1 1 1 1 DASH complex subunit Ask1 Frag1 PF10277.4 AMD20856.1 - 2.5e-74 249.3 23.8 3e-74 249.1 16.5 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF3812 PF12757.2 AMD20857.1 - 2.3e-29 101.9 3.6 2.3e-29 101.9 2.5 4.9 3 1 1 4 4 4 1 Protein of unknown function (DUF3812) FCH PF00611.18 AMD20858.1 - 1e-17 64.0 0.1 1e-17 64.0 0.1 4.1 4 1 0 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.1 AMD20858.1 - 8.8e-09 34.8 0.0 1.6e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 AMD20858.1 - 1e-07 31.2 0.1 2e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 AMD20858.1 - 8.3e-07 28.4 0.0 1.7e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Histone PF00125.19 AMD20859.1 - 3.8e-26 90.9 1.1 9.1e-26 89.7 0.5 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 AMD20859.1 - 0.0036 17.4 0.1 0.007 16.5 0.1 1.4 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 AMD20859.1 - 0.1 12.6 0.1 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Actin PF00022.14 AMD20860.1 - 2.6e-21 75.5 0.2 2.3e-18 65.7 0.0 2.8 2 1 0 2 2 2 2 Actin MutL PF13941.1 AMD20860.1 - 0.046 12.0 0.1 0.97 7.6 0.0 2.1 2 0 0 2 2 2 0 MutL protein Hydantoinase_A PF01968.13 AMD20860.1 - 0.11 11.6 0.1 0.21 10.6 0.1 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase DUF4137 PF13593.1 AMD20861.1 - 2.3e-101 339.0 14.0 2.6e-101 338.8 9.7 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.11 AMD20861.1 - 2e-11 43.6 9.9 6e-11 42.0 6.6 1.9 1 1 0 1 1 1 1 Sodium Bile acid symporter family Peptidase_S24 PF00717.18 AMD20862.1 - 3.2e-07 29.8 0.2 6.3e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.4 AMD20862.1 - 2.3e-06 27.1 0.0 7.6e-05 22.2 0.0 2.2 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Rhodanese PF00581.15 AMD20863.1 - 2.3e-09 37.6 0.0 5.6e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.20 AMD20864.1 - 2.5e-35 121.8 0.2 3e-32 111.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20864.1 - 1.7e-16 60.1 0.0 3.4e-12 45.9 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Kinase-like PF14531.1 AMD20864.1 - 6.1e-05 22.1 0.0 0.073 12.0 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 AMD20864.1 - 0.0029 17.3 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-C2H2 PF00096.21 AMD20865.1 - 8.3e-13 47.8 13.3 5.6e-06 26.3 2.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD20865.1 - 3e-10 39.6 13.3 6.9e-05 22.8 2.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD20865.1 - 5.1e-07 29.6 20.5 3.2e-06 27.1 2.4 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 AMD20865.1 - 3.8e-06 26.8 8.7 0.00067 19.7 1.4 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 AMD20865.1 - 5.9e-05 22.7 6.0 0.024 14.3 0.9 2.6 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.1 AMD20865.1 - 0.0013 18.5 0.7 0.0013 18.5 0.5 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.2 AMD20865.1 - 0.12 12.6 5.5 1.2 9.3 0.5 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 AMD20865.1 - 0.18 11.9 6.4 0.62 10.2 0.5 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.7 AMD20865.1 - 0.34 11.0 5.5 1.1 9.4 3.8 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF629 PF04780.7 AMD20865.1 - 1 7.7 6.6 0.67 8.4 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) GAGA PF09237.6 AMD20865.1 - 8.5 6.0 7.3 3.7 7.2 0.6 3.0 2 1 1 3 3 3 0 GAGA factor Seryl_tRNA_N PF02403.17 AMD20866.1 - 0.057 13.4 2.0 0.078 12.9 1.4 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HMA PF00403.21 AMD20867.1 - 7.7e-12 45.1 0.1 3.7e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Heavy-metal-associated domain CorA PF01544.13 AMD20868.1 - 1.2e-40 139.4 5.9 4.6e-23 81.6 0.8 3.4 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein PC4 PF02229.11 AMD20869.1 - 4.2e-22 77.1 0.0 9.7e-22 75.9 0.0 1.6 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) NusB PF01029.13 AMD20869.1 - 0.18 11.7 0.9 11 5.9 0.1 2.3 2 0 0 2 2 2 0 NusB family FRG2 PF15315.1 AMD20869.1 - 1 9.2 8.2 4.2 7.3 3.9 2.4 1 1 1 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 Aldo_ket_red PF00248.16 AMD20870.1 - 3.9e-47 160.4 0.0 4.7e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Bap31 PF05529.7 AMD20871.1 - 1.1e-42 145.7 5.3 2.4e-42 144.5 3.7 1.6 1 1 0 1 1 1 1 B-cell receptor-associated protein 31-like ADIP PF11559.3 AMD20871.1 - 0.00014 21.8 2.4 0.00017 21.5 1.6 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding HemX PF04375.9 AMD20871.1 - 0.0039 15.8 1.9 0.067 11.7 0.8 2.0 2 0 0 2 2 2 1 HemX IncA PF04156.9 AMD20871.1 - 0.022 14.3 1.0 0.022 14.3 0.7 1.5 2 0 0 2 2 2 0 IncA protein DUF4140 PF13600.1 AMD20871.1 - 0.026 14.9 1.4 0.041 14.3 1.0 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) MRG PF05712.8 AMD20871.1 - 0.038 12.8 0.5 0.13 11.1 0.1 1.9 1 1 1 2 2 2 0 MRG TMF_DNA_bd PF12329.3 AMD20871.1 - 0.047 13.5 10.4 0.08 12.7 7.2 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 AMD20871.1 - 0.24 10.8 5.2 0.47 9.9 3.6 1.5 1 0 0 1 1 1 0 Septum formation initiator Ax_dynein_light PF10211.4 AMD20871.1 - 1.5 8.6 7.3 2 8.2 5.1 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain NDK PF00334.14 AMD20872.1 - 7e-55 184.5 0.0 8.1e-55 184.3 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PWWP PF00855.12 AMD20873.1 - 1e-16 60.8 2.2 1.5e-16 60.3 0.2 2.3 2 0 0 2 2 2 1 PWWP domain SRF-TF PF00319.13 AMD20874.1 - 8.9e-24 82.4 0.2 1.2e-23 82.0 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) TFIIE-A_C-term PF11521.3 AMD20874.1 - 0.0099 15.7 1.8 0.0099 15.7 1.3 2.0 3 0 0 3 3 3 1 C-terminal general transcription factor TFIIE alpha Metal_resist PF13801.1 AMD20874.1 - 0.013 15.4 0.9 0.025 14.5 0.6 1.5 1 0 0 1 1 1 0 Heavy-metal resistance CENP-B_dimeris PF09026.5 AMD20874.1 - 0.52 10.5 5.3 1.2 9.3 3.6 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nucleoporin_FG PF13634.1 AMD20875.1 - 1.4e-57 192.8 401.3 8.5e-13 48.5 28.2 12.6 2 2 8 11 11 11 9 Nucleoporin FG repeat region Nucleoporin2 PF04096.9 AMD20875.1 - 2.3e-39 134.4 0.0 3.7e-39 133.7 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Yeast_MT PF11403.3 AMD20876.1 - 0.089 12.9 1.2 0.16 12.1 0.8 1.4 1 0 0 1 1 1 0 Yeast metallothionein Bd3614_N PF14442.1 AMD20876.1 - 0.16 11.9 0.8 0.16 11.9 0.6 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Pox_Ag35 PF03286.9 AMD20876.1 - 0.22 11.0 1.6 0.24 10.8 1.1 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF3245 PF11595.3 AMD20876.1 - 1.9 8.7 4.9 2.5 8.3 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Swi3 PF07962.7 AMD20877.1 - 2.1e-28 97.7 0.3 4e-28 96.8 0.2 1.5 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 BOP1NT PF08145.7 AMD20878.1 - 3.2e-104 348.2 8.4 5.4e-104 347.5 5.8 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 AMD20878.1 - 4.7e-30 102.3 4.4 2e-11 43.2 0.4 7.4 7 1 0 7 7 7 4 WD domain, G-beta repeat Aminotran_5 PF00266.14 AMD20878.1 - 0.22 10.2 0.0 0.4 9.3 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V DUF1289 PF06945.8 AMD20878.1 - 0.24 10.8 0.4 0.59 9.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) GAF_2 PF13185.1 AMD20879.1 - 7.9e-11 42.6 0.0 8.7e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.21 AMD20879.1 - 0.00019 21.5 0.0 0.00026 21.1 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.1 AMD20879.1 - 0.096 12.7 0.0 0.11 12.6 0.0 1.3 1 1 0 1 1 1 0 GAF domain HGD-D PF06050.8 AMD20880.1 - 0.25 10.0 2.0 0.18 10.6 0.2 1.6 2 0 0 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component PG_binding_1 PF01471.13 AMD20881.1 - 1.6e-05 24.7 0.0 0.00019 21.3 0.0 2.4 2 0 0 2 2 2 1 Putative peptidoglycan binding domain THP2 PF09432.5 AMD20881.1 - 0.0066 16.3 0.4 0.018 14.9 0.3 1.7 1 0 0 1 1 1 1 Tho complex subunit THP2 COG5 PF10392.4 AMD20881.1 - 0.0082 16.1 0.5 0.017 15.0 0.3 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 DUF1664 PF07889.7 AMD20881.1 - 0.044 13.5 0.6 0.12 12.1 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Lectin_N PF03954.9 AMD20881.1 - 0.13 11.6 3.1 0.11 11.8 0.6 2.0 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain V_ATPase_I PF01496.14 AMD20882.1 - 2e-278 925.3 8.6 2.3e-278 925.1 6.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family BLOC1_2 PF10046.4 AMD20882.1 - 0.25 11.4 5.1 0.52 10.4 0.2 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med9 PF07544.8 AMD20882.1 - 0.26 11.0 1.9 1 9.1 0.5 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HSP70 PF00012.15 AMD20883.1 - 4.2e-46 157.0 1.3 5e-46 156.8 0.0 1.7 1 1 0 1 1 1 1 Hsp70 protein RNA_pol_Rpb1_5 PF04998.12 AMD20883.1 - 1.7 7.8 6.2 3.7 6.7 4.3 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 RRM_1 PF00076.17 AMD20884.1 - 0.0086 15.6 0.0 0.03 13.9 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD20884.1 - 0.028 14.2 0.0 0.062 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RabGAP-TBC PF00566.13 AMD20885.1 - 1.4e-33 116.1 0.0 2.2e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Cu-oxidase_3 PF07732.10 AMD20886.1 - 9.1e-42 141.5 3.2 3.4e-40 136.4 0.2 3.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 AMD20886.1 - 9.3e-42 141.8 6.9 1.1e-37 128.5 0.2 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.17 AMD20886.1 - 3.3e-33 114.8 0.6 1.4e-30 106.2 0.2 3.3 3 0 0 3 3 3 2 Multicopper oxidase DNA_pol3_alpha PF07733.7 AMD20887.1 - 0.0017 16.8 0.3 0.0094 14.4 0.1 2.0 1 1 1 2 2 2 1 Bacterial DNA polymerase III alpha subunit DUF4448 PF14610.1 AMD20888.1 - 4.9e-53 179.4 1.4 8e-53 178.7 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Neur_chan_memb PF02932.11 AMD20888.1 - 0.028 14.3 0.5 0.028 14.3 0.4 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Sorb PF02208.11 AMD20888.1 - 0.031 13.6 0.1 0.13 11.6 0.1 2.0 1 0 0 1 1 1 0 Sorbin homologous domain Sen15 PF09631.5 AMD20889.1 - 5.7e-25 87.4 0.1 6.4e-25 87.3 0.0 1.0 1 0 0 1 1 1 1 Sen15 protein Tom37_C PF11801.3 AMD20890.1 - 3.6e-38 131.0 4.4 4.5e-38 130.7 3.0 1.1 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.4 AMD20890.1 - 7.9e-21 74.1 0.6 1.3e-20 73.3 0.4 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein Suf PF05843.9 AMD20891.1 - 2e-71 241.0 24.3 4.2e-59 200.5 3.7 5.7 4 2 1 5 5 5 4 Suppressor of forked protein (Suf) TPR_19 PF14559.1 AMD20891.1 - 0.0021 18.3 0.1 0.009 16.3 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 AMD20891.1 - 0.059 14.0 0.0 1.6 9.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2795 PF11387.3 AMD20891.1 - 0.064 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) ArgJ PF01960.13 AMD20892.1 - 7e-135 449.3 3.1 8e-135 449.1 2.2 1.0 1 0 0 1 1 1 1 ArgJ family Sugar_tr PF00083.19 AMD20893.1 - 8e-113 377.3 18.6 9.2e-113 377.1 12.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD20893.1 - 7.3e-24 84.1 25.6 1.4e-17 63.4 5.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OppC_N PF12911.2 AMD20893.1 - 0.033 13.5 0.2 0.12 11.7 0.1 1.9 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C HA2 PF04408.18 AMD20894.1 - 8.1e-19 67.5 0.0 1.6e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 AMD20894.1 - 1.4e-14 53.8 0.0 2.7e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 AMD20894.1 - 7e-12 45.0 0.0 1.8e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AMD20894.1 - 1.4e-07 31.1 0.3 2.8e-07 30.2 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 AMD20894.1 - 7.2e-06 26.1 0.2 1.7e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 AMD20894.1 - 7.4e-05 22.3 0.1 0.35 10.2 0.0 3.3 2 1 0 2 2 2 2 AAA-like domain AAA_29 PF13555.1 AMD20894.1 - 0.0017 17.8 0.0 0.0056 16.1 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 AMD20894.1 - 0.0031 16.9 0.0 0.0066 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD20894.1 - 0.0033 17.1 0.4 0.0073 16.0 0.3 1.6 1 0 0 1 1 1 1 Part of AAA domain SRP54 PF00448.17 AMD20894.1 - 0.0091 15.4 0.4 0.03 13.7 0.3 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.9 AMD20894.1 - 0.013 15.2 0.2 0.15 11.8 0.1 2.2 2 0 0 2 2 2 0 Flavivirus DEAD domain DUF258 PF03193.11 AMD20894.1 - 0.02 14.0 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 AMD20894.1 - 0.039 14.2 0.8 0.16 12.2 0.4 1.8 1 1 0 2 2 2 0 ABC transporter T2SE PF00437.15 AMD20894.1 - 0.11 11.4 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.1 AMD20894.1 - 0.12 12.6 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain SUR7 PF06687.7 AMD20895.1 - 5.6e-18 65.2 19.6 7.2e-18 64.9 13.6 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2198 PF09964.4 AMD20895.1 - 0.6 9.8 7.1 7.4 6.4 0.0 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) DUF1280 PF06918.9 AMD20896.1 - 0.009 15.2 0.1 0.016 14.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1280) Vps54 PF07928.7 AMD20896.1 - 0.16 12.1 1.2 14 5.8 0.0 2.7 2 0 0 2 2 2 0 Vps54-like protein Tht1 PF04163.7 AMD20897.1 - 7.2e-38 130.2 15.7 2.5e-36 125.2 1.3 2.1 1 1 1 2 2 2 2 Tht1-like nuclear fusion protein Apolipoprotein PF01442.13 AMD20897.1 - 1.5e-05 24.5 5.2 0.00078 19.0 3.7 2.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF948 PF06103.6 AMD20897.1 - 0.00042 20.1 12.6 0.0051 16.6 1.2 3.8 3 1 0 3 3 3 1 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.7 AMD20897.1 - 0.00065 19.9 13.1 0.039 14.2 1.5 3.2 3 0 0 3 3 2 2 Nucleopolyhedrovirus P10 protein DUF3552 PF12072.3 AMD20897.1 - 0.0029 16.8 3.3 1 8.5 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) AAA_13 PF13166.1 AMD20897.1 - 0.0068 14.9 14.1 0.17 10.3 5.2 2.1 1 1 1 2 2 2 2 AAA domain DUF1548 PF07579.6 AMD20897.1 - 0.0071 16.4 4.3 0.024 14.7 1.5 2.4 1 1 0 2 2 2 1 Domain of Unknown Function (DUF1548) Baculo_PEP_C PF04513.7 AMD20897.1 - 0.0082 15.9 17.9 0.055 13.2 2.6 3.4 2 1 1 4 4 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Muted PF14942.1 AMD20897.1 - 0.016 15.0 5.6 1.8 8.3 1.2 2.6 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein COG2 PF06148.6 AMD20897.1 - 0.016 15.0 11.3 1 9.2 3.6 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin-6_N PF09177.6 AMD20897.1 - 0.019 15.3 8.9 1.9 8.9 2.7 3.5 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Carbpep_Y_N PF05388.6 AMD20897.1 - 0.019 15.0 7.4 1.2 9.3 0.4 3.5 2 1 1 3 3 3 0 Carboxypeptidase Y pro-peptide FliJ PF02050.11 AMD20897.1 - 0.021 14.8 1.5 0.061 13.3 0.6 2.1 2 0 0 2 2 1 0 Flagellar FliJ protein DUF4546 PF15079.1 AMD20897.1 - 0.025 13.7 1.4 0.053 12.6 0.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4546) s48_45 PF07422.8 AMD20897.1 - 0.051 13.6 0.2 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain DUF2960 PF11173.3 AMD20897.1 - 0.052 13.8 0.2 0.12 12.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2960) ATP-synt_B PF00430.13 AMD20897.1 - 0.072 12.8 0.4 0.072 12.8 0.3 2.4 2 1 1 3 3 3 0 ATP synthase B/B' CF(0) ApoLp-III PF07464.6 AMD20897.1 - 0.12 12.4 7.5 0.89 9.5 2.5 2.5 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Phage_GPO PF05929.6 AMD20897.1 - 0.14 11.4 3.6 1.5 7.9 1.1 2.2 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase LMP PF04778.7 AMD20897.1 - 0.17 11.6 8.9 0.081 12.6 3.5 2.2 2 0 0 2 2 2 0 LMP repeated region DUF2935 PF11155.3 AMD20897.1 - 0.23 11.5 2.9 1.6 8.8 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) Pox_A_type_inc PF04508.7 AMD20897.1 - 0.28 11.0 2.3 21 5.2 0.0 3.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Nup54 PF13874.1 AMD20897.1 - 0.62 9.7 3.1 3.7 7.1 0.9 2.5 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Nsp1_C PF05064.8 AMD20897.1 - 1.2 8.7 9.2 0.28 10.8 3.3 2.2 2 0 0 2 2 2 0 Nsp1-like C-terminal region YtxH PF12732.2 AMD20897.1 - 1.5 9.2 6.0 4e+02 1.4 4.2 3.3 1 1 0 1 1 1 0 YtxH-like protein Exonuc_VII_L PF02601.10 AMD20897.1 - 3 6.9 8.3 11 5.1 5.7 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit TBPIP PF07106.8 AMD20897.1 - 5.1 6.6 10.7 9.4 5.7 4.4 2.6 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Fzo_mitofusin PF04799.8 AMD20897.1 - 6.4 6.1 7.1 9.2 5.6 1.6 2.6 2 1 0 2 2 2 0 fzo-like conserved region Med2 PF11214.3 AMD20897.1 - 6.6 6.8 12.4 0.16 11.9 0.4 3.1 3 1 0 3 3 3 0 Mediator complex subunit 2 FlxA PF14282.1 AMD20897.1 - 7.3 6.5 7.6 44 4.0 2.3 2.6 2 0 0 2 2 2 0 FlxA-like protein Endonuclease_NS PF01223.18 AMD20898.1 - 7.4e-59 198.8 0.0 9e-59 198.5 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease FAM150 PF15129.1 AMD20898.1 - 0.0077 16.1 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 FAM150 family Endonuclea_NS_2 PF13930.1 AMD20898.1 - 0.026 14.5 0.0 0.058 13.4 0.0 1.7 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease Kinesin PF00225.18 AMD20899.1 - 1.7e-97 326.1 1.1 1.7e-97 326.1 0.8 1.6 2 0 0 2 2 2 1 Kinesin motor domain ADIP PF11559.3 AMD20899.1 - 0.72 9.7 34.0 1.2 9.0 10.7 2.6 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Nup54 PF13874.1 AMD20899.1 - 4.4 6.9 20.8 0.4 10.3 3.0 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 V-ATPase_C PF03223.10 AMD20900.1 - 4.1e-124 414.2 3.4 4.6e-124 414.1 2.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C EF1G PF00647.14 AMD20901.1 - 1.5e-46 156.5 0.2 2.9e-46 155.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 AMD20901.1 - 3.3e-08 33.3 0.0 3.3e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 AMD20901.1 - 7.7e-06 25.9 0.1 5.2e-05 23.3 0.0 2.5 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 AMD20901.1 - 0.0016 18.6 0.1 0.005 17.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 AMD20901.1 - 0.017 15.0 0.0 0.042 13.7 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SURF6 PF04935.7 AMD20902.1 - 1.1e-50 171.9 46.9 1.1e-50 171.9 32.5 2.7 2 1 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.1 AMD20902.1 - 4.4e-17 61.8 3.1 4.4e-17 61.8 2.2 6.2 4 2 0 4 4 4 1 60S ribosome biogenesis protein Rrp14 CX PF01705.14 AMD20902.1 - 0.24 11.3 0.8 1.8 8.6 0.0 2.4 2 0 0 2 2 2 0 CX module UBX PF00789.15 AMD20904.1 - 4.7e-10 39.3 0.0 1.5e-09 37.8 0.0 1.9 1 0 0 1 1 1 1 UBX domain TUG-UBL1 PF11470.3 AMD20904.1 - 1.6e-08 34.2 0.0 4.3e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 GLUT4 regulating protein TUG Ank_2 PF12796.2 AMD20905.1 - 3.8e-39 132.9 11.4 1.3e-14 54.2 0.5 2.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 AMD20905.1 - 1.7e-21 76.1 6.0 9.8e-10 38.6 0.4 4.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 AMD20905.1 - 1.9e-20 71.5 9.9 1.6e-05 24.4 0.2 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 AMD20905.1 - 1.4e-15 56.9 4.0 3.2e-06 27.2 0.0 4.2 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 AMD20905.1 - 1.6e-12 46.3 5.8 0.0079 16.3 0.1 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ldh_1_C PF02866.13 AMD20906.1 - 2.6e-46 157.4 0.0 4.8e-46 156.6 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 AMD20906.1 - 1.7e-41 141.3 0.0 2.4e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 AMD20906.1 - 0.00011 21.0 0.0 0.00015 20.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 AMD20906.1 - 0.073 13.0 0.3 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 NADH(P)-binding ParBc PF02195.13 AMD20907.1 - 7e-12 45.3 0.0 8.9e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain G-alpha PF00503.15 AMD20908.1 - 9.2e-118 393.2 0.1 1e-117 393.1 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 AMD20908.1 - 6.9e-15 54.7 1.2 1.1e-09 37.7 0.0 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 AMD20908.1 - 0.0005 20.5 0.0 0.38 11.2 0.0 2.5 2 0 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 AMD20908.1 - 0.00072 18.7 0.3 0.079 12.0 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 AMD20908.1 - 0.05 13.5 0.0 13 5.7 0.0 2.8 3 0 0 3 3 3 0 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD20908.1 - 0.064 12.6 0.1 2.1 7.7 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 AMD20908.1 - 0.13 11.8 0.1 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cyto_heme_lyase PF01265.12 AMD20909.1 - 2.9e-84 282.6 0.0 3.3e-84 282.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase zf-Tim10_DDP PF02953.10 AMD20910.1 - 4.8e-23 80.2 2.0 5.7e-23 79.9 1.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 AMD20910.1 - 0.0072 15.7 1.1 0.01 15.2 0.8 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Tom5 PF10642.4 AMD20910.1 - 0.02 14.5 0.2 0.031 13.9 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Flavoprotein PF02441.14 AMD20911.1 - 1.3e-45 154.2 0.0 2e-45 153.6 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein DUF1510 PF07423.6 AMD20911.1 - 2.4 7.4 15.8 3.9 6.7 11.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SDA1 PF05285.7 AMD20911.1 - 4.6 6.4 21.3 6.8 5.8 14.8 1.1 1 0 0 1 1 1 0 SDA1 Ydc2-catalyt PF09159.5 AMD20913.1 - 1.4e-42 146.1 0.5 1.8e-42 145.7 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.8 AMD20913.1 - 0.00061 19.6 0.6 0.76 9.6 0.1 3.1 2 1 0 2 2 2 2 Poxvirus A22 protein NAD_binding_10 PF13460.1 AMD20914.1 - 7.4e-30 104.3 0.0 9.1e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 AMD20914.1 - 6.2e-11 41.9 0.1 2e-10 40.3 0.1 1.7 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 AMD20914.1 - 1.9e-07 30.7 0.0 2.8e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 AMD20914.1 - 3.1e-06 26.0 0.1 5.1e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 AMD20914.1 - 6.7e-05 23.1 0.2 0.00013 22.2 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.7 AMD20914.1 - 0.00019 20.4 0.0 0.037 12.9 0.0 2.5 1 1 1 2 2 2 2 Male sterility protein DapB_N PF01113.15 AMD20914.1 - 0.00062 19.6 0.4 0.0012 18.7 0.3 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.18 AMD20914.1 - 0.00071 19.4 0.5 0.0016 18.2 0.3 1.7 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 AMD20914.1 - 0.0023 16.8 0.0 0.0057 15.5 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain GARS_N PF02844.10 AMD20914.1 - 0.02 15.3 0.3 0.059 13.8 0.1 1.8 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, N domain Polysacc_synt_2 PF02719.10 AMD20914.1 - 0.068 12.0 0.2 0.73 8.6 0.1 2.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_Gly3P_dh_N PF01210.18 AMD20914.1 - 0.083 12.6 0.1 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Peptidase_S24 PF00717.18 AMD20915.1 - 1.4e-08 34.2 0.1 2.5e-08 33.4 0.1 1.5 1 1 0 1 1 1 1 Peptidase S24-like FF PF01846.14 AMD20916.1 - 2.5e-37 126.5 11.8 2.8e-12 46.3 0.2 5.3 4 0 0 4 4 4 4 FF domain WW PF00397.21 AMD20916.1 - 1.4e-18 66.4 15.0 2.2e-11 43.4 0.9 3.6 3 0 0 3 3 3 2 WW domain ARPC4 PF05856.7 AMD20917.1 - 2.2e-69 232.2 6.4 2.4e-69 232.0 4.4 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Fungal_trans PF04082.13 AMD20918.1 - 5.4e-25 87.7 0.6 5.4e-25 87.7 0.4 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD20918.1 - 2.8e-06 27.1 7.7 6.1e-06 26.0 5.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amnionless PF14828.1 AMD20919.1 - 0.03 12.8 0.2 0.04 12.4 0.1 1.2 1 0 0 1 1 1 0 Amnionless COX16 PF14138.1 AMD20919.1 - 0.26 11.4 1.8 0.33 11.1 0.1 2.1 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Z1 PF10593.4 AMD20919.1 - 0.34 10.0 3.8 0.61 9.2 2.5 1.4 1 1 0 1 1 1 0 Z1 domain Syntaxin PF00804.20 AMD20919.1 - 5.7 7.1 8.9 0.56 10.4 3.1 1.6 2 0 0 2 2 2 0 Syntaxin Npa1 PF11707.3 AMD20920.1 - 3.5e-100 335.2 2.8 3.5e-100 335.2 2.0 2.4 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal Fungal_trans PF04082.13 AMD20921.1 - 2e-24 85.8 0.1 3.2e-24 85.1 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD20921.1 - 2.5e-09 36.8 6.7 6.5e-09 35.5 4.6 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mt_ATP-synt_D PF05873.7 AMD20922.1 - 2.3e-15 56.5 3.1 3e-15 56.2 2.1 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) EzrA PF06160.7 AMD20922.1 - 0.00038 18.7 5.5 0.00083 17.6 3.0 1.7 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA Dor1 PF04124.7 AMD20922.1 - 0.0017 16.9 2.8 0.002 16.6 1.9 1.1 1 0 0 1 1 1 1 Dor1-like family DUF4201 PF13870.1 AMD20922.1 - 0.0088 15.4 2.6 0.023 14.1 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) LTXXQ PF07813.7 AMD20922.1 - 0.033 14.6 3.4 1.3 9.5 0.4 2.2 2 0 0 2 2 2 0 LTXXQ motif family protein Vps51 PF08700.6 AMD20922.1 - 0.086 12.6 1.0 0.23 11.3 0.1 2.1 2 1 0 2 2 2 0 Vps51/Vps67 Myosin_tail_1 PF01576.14 AMD20922.1 - 0.092 10.4 8.2 0.053 11.2 2.3 1.8 1 1 1 2 2 2 0 Myosin tail DUF1319 PF07028.6 AMD20922.1 - 0.1 12.7 6.3 0.14 12.3 0.7 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1319) Baculo_PEP_C PF04513.7 AMD20922.1 - 0.14 11.9 2.4 1.3 8.8 1.7 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 AMD20922.1 - 0.15 11.6 2.6 0.2 11.2 1.8 1.1 1 0 0 1 1 1 0 IncA protein Phage_GP20 PF06810.6 AMD20922.1 - 0.34 10.3 5.2 3.8 6.9 0.5 2.2 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF4404 PF14357.1 AMD20922.1 - 0.35 11.3 4.8 0.2 12.0 1.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF2408 PF10303.4 AMD20922.1 - 0.6 10.2 3.9 2.7 8.1 2.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) AAA_12 PF13087.1 AMD20923.1 - 2.5e-59 200.0 0.0 5e-59 199.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 AMD20923.1 - 3.3e-53 180.6 1.4 4.8e-53 180.1 0.4 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 AMD20923.1 - 5.2e-14 51.7 0.0 1.2e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 AMD20923.1 - 3.2e-10 39.9 0.0 3.6e-08 33.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 AMD20923.1 - 7.8e-07 28.8 0.1 0.44 10.0 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 AMD20923.1 - 8.1e-07 28.6 0.2 0.00091 18.6 0.1 2.4 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain DEAD PF00270.24 AMD20923.1 - 1.2e-06 28.1 0.5 8.9e-05 22.0 0.4 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 AMD20923.1 - 3.6e-05 23.6 0.0 0.00014 21.7 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.11 AMD20923.1 - 6.5e-05 22.2 0.0 0.0043 16.2 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.1 AMD20923.1 - 0.00026 21.1 0.1 0.002 18.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.9 AMD20923.1 - 0.00045 19.8 0.0 0.0044 16.6 0.0 2.7 2 1 0 2 2 2 1 Helicase T2SE PF00437.15 AMD20923.1 - 0.0017 17.3 0.0 0.0048 15.8 0.0 1.6 1 1 0 1 1 1 1 Type II/IV secretion system protein Zot PF05707.7 AMD20923.1 - 0.002 17.5 0.0 0.0049 16.3 0.0 1.7 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) AAA PF00004.24 AMD20923.1 - 0.0028 17.8 0.9 0.24 11.5 0.0 3.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 AMD20923.1 - 0.0063 16.4 0.2 0.64 9.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.4 AMD20923.1 - 0.009 15.0 0.3 0.26 10.2 0.0 2.7 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.4 AMD20923.1 - 0.016 13.8 0.0 0.031 12.9 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_17 PF13207.1 AMD20923.1 - 0.021 15.6 0.6 0.25 12.1 0.2 2.8 2 2 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 AMD20923.1 - 0.029 13.7 0.0 0.089 12.2 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_10 PF12846.2 AMD20923.1 - 0.036 13.5 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.1 AMD20923.1 - 0.044 13.7 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.1 AMD20923.1 - 0.048 13.0 0.0 0.16 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 AMD20923.1 - 0.053 13.2 0.0 0.17 11.5 0.0 1.9 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) UvrD_C_2 PF13538.1 AMD20923.1 - 0.057 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Flavi_DEAD PF07652.9 AMD20923.1 - 0.075 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_33 PF13671.1 AMD20923.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 AMD20923.1 - 0.28 11.5 4.7 0.89 9.8 0.8 3.4 3 1 1 4 4 3 0 AAA domain WD40 PF00400.27 AMD20924.1 - 2.1e-15 55.9 0.1 3.5e-05 23.5 0.0 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 AMD20924.1 - 0.0082 14.4 0.0 0.24 9.6 0.0 2.4 2 1 0 2 2 2 2 Cytochrome D1 heme domain DUF3312 PF11768.3 AMD20924.1 - 0.14 10.3 0.0 0.47 8.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) DUF1748 PF08520.5 AMD20925.1 - 1.1e-22 79.3 0.1 1.4e-22 79.0 0.1 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Apc15p PF05841.6 AMD20926.1 - 2.8e-13 50.6 1.8 3.2e-13 50.4 0.1 1.9 1 1 1 2 2 2 1 Apc15p protein DSPc PF00782.15 AMD20927.1 - 1.2e-25 89.5 2.0 1.8e-24 85.8 0.6 2.7 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 AMD20927.1 - 0.00015 21.1 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 AMD20927.1 - 0.014 15.4 0.0 0.067 13.2 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate Yippee-Mis18 PF03226.9 AMD20927.1 - 0.017 15.1 1.4 0.18 11.8 0.9 2.4 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Elf1 PF05129.8 AMD20927.1 - 0.03 13.9 0.5 1.9 8.2 0.0 2.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like PPTA PF01239.17 AMD20928.1 - 6.8e-38 126.4 17.1 1e-08 34.1 0.1 5.8 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat LHH PF14411.1 AMD20928.1 - 0.045 13.9 0.1 0.11 12.7 0.1 1.7 1 0 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH Ank PF00023.25 AMD20929.1 - 7e-14 50.8 0.0 5.4e-07 29.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 AMD20929.1 - 2.7e-12 46.8 0.1 6e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) TIG PF01833.19 AMD20929.1 - 6.8e-09 35.6 0.3 3.9e-08 33.1 0.2 2.3 2 0 0 2 2 2 1 IPT/TIG domain Ank_4 PF13637.1 AMD20929.1 - 6.3e-08 32.9 0.0 1.8e-07 31.4 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 AMD20929.1 - 9.7e-08 31.5 0.1 0.00072 19.5 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 AMD20929.1 - 1.2e-07 31.7 0.0 6.3e-05 23.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) WD40 PF00400.27 AMD20930.1 - 1e-33 113.9 3.6 4.6e-10 38.9 0.2 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat Nucleoporin_N PF08801.6 AMD20930.1 - 5.2e-06 25.4 2.4 0.22 10.2 0.0 4.3 1 1 3 4 4 4 3 Nup133 N terminal like Nup160 PF11715.3 AMD20930.1 - 9.1e-06 24.0 0.5 0.028 12.5 0.2 2.5 2 1 0 2 2 2 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 AMD20930.1 - 0.0054 16.5 1.3 3.9 7.2 0.0 3.9 5 0 0 5 5 5 1 Ciliary BBSome complex subunit 2, middle region SUKH_5 PF14567.1 AMD20930.1 - 0.017 14.6 1.1 0.49 9.8 0.1 2.9 2 1 0 2 2 2 0 SMI1-KNR4 cell-wall CRT10 PF08728.5 AMD20930.1 - 0.017 13.1 0.3 0.092 10.7 0.0 2.0 2 0 0 2 2 2 0 CRT10 Hira PF07569.6 AMD20930.1 - 0.029 13.5 0.1 0.28 10.3 0.0 2.4 3 0 0 3 3 3 0 TUP1-like enhancer of split DUF1312 PF07009.6 AMD20930.1 - 1.6 8.5 4.2 2.4 7.9 0.5 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1312) AlaDh_PNT_N PF05222.10 AMD20931.1 - 4.5e-29 101.1 0.0 6.9e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 AMD20931.1 - 8e-13 48.2 0.0 1.1e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TPR_1 PF00515.23 AMD20932.1 - 4e-38 127.4 10.9 2.5e-06 26.8 0.0 10.1 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20932.1 - 1.1e-34 115.5 6.7 0.00033 20.3 0.0 10.1 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.1 AMD20932.1 - 6.4e-32 109.0 10.0 2.3e-08 33.5 0.0 7.2 4 2 0 6 6 6 5 TPR repeat Apc3 PF12895.2 AMD20932.1 - 4.5e-31 106.8 10.9 1.2e-21 76.6 0.1 5.4 3 2 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 AMD20932.1 - 2.4e-24 85.0 6.9 1.4e-07 31.3 0.0 7.8 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20932.1 - 4.1e-20 69.9 8.3 0.0089 15.7 0.0 8.1 10 0 0 10 10 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 AMD20932.1 - 6.1e-20 71.3 0.0 9.2e-05 23.0 0.0 6.6 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 AMD20932.1 - 1.6e-19 69.9 0.2 6.8e-05 23.1 0.1 7.4 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 AMD20932.1 - 4.2e-17 61.0 0.0 0.013 16.0 0.0 7.8 4 2 4 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.1 AMD20932.1 - 1.1e-16 59.5 4.0 0.0098 16.0 0.0 9.4 9 1 0 10 10 10 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD20932.1 - 3.6e-14 51.3 1.7 0.0073 16.0 0.0 7.5 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_10 PF13374.1 AMD20932.1 - 1.2e-10 40.8 0.1 0.55 10.2 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 AMD20932.1 - 7.2e-09 35.5 11.2 0.97 10.0 0.1 8.4 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_15 PF13429.1 AMD20932.1 - 1e-07 31.3 2.0 0.1 11.6 0.0 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_3 PF07720.7 AMD20932.1 - 1.5e-06 27.8 4.7 0.16 11.7 0.0 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 AMD20932.1 - 3.5e-06 26.7 0.1 0.0071 16.1 0.0 4.7 6 1 1 7 7 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 AMD20932.1 - 7.3e-05 22.5 6.8 4.8 7.1 0.0 5.8 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.5 AMD20932.1 - 0.00026 19.8 0.8 0.077 11.7 0.0 3.4 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.1 AMD20932.1 - 0.017 15.2 0.0 3.2 7.9 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.4 AMD20932.1 - 0.067 13.1 4.0 9.9 6.0 0.0 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 AMD20932.1 - 2.3 8.9 6.8 33 5.2 0.0 4.2 4 1 0 4 4 2 0 Sel1 repeat ADK PF00406.17 AMD20933.1 - 5.7e-45 152.8 0.0 7.4e-45 152.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 AMD20933.1 - 1.1e-11 45.1 0.0 1.8e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AMD20933.1 - 1e-09 38.4 0.0 1.8e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD20933.1 - 1.8e-07 32.0 0.0 2.6e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 AMD20933.1 - 4.9e-07 29.0 0.0 7e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.12 AMD20933.1 - 6.4e-05 22.4 0.4 0.13 11.6 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase AAA_19 PF13245.1 AMD20933.1 - 0.027 14.2 0.1 0.074 12.8 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain adh_short PF00106.20 AMD20934.1 - 8.5e-30 103.8 0.3 1.2e-29 103.4 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AMD20934.1 - 2.7e-15 56.8 0.0 3.2e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AMD20934.1 - 2.3e-12 46.9 0.1 3.4e-12 46.3 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 AMD20934.1 - 0.003 17.0 0.1 0.0097 15.3 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 AMD20934.1 - 0.02 14.9 0.0 0.034 14.1 0.0 1.4 1 1 0 1 1 1 0 NADH(P)-binding AA_permease_2 PF13520.1 AMD20937.1 - 3.4e-74 249.9 48.9 4.2e-74 249.6 33.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AMD20937.1 - 5.4e-19 67.8 45.1 2.4e-18 65.7 31.3 1.7 1 1 0 1 1 1 1 Amino acid permease SUI1 PF01253.17 AMD20938.1 - 7.9e-29 99.3 0.4 9.5e-29 99.0 0.3 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.3 AMD20938.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Cas_Csa5 PF09702.5 AMD20938.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) Homeobox PF00046.24 AMD20939.1 - 1.7e-15 56.3 1.8 2e-15 56.1 1.3 1.1 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 AMD20939.1 - 1e-05 25.1 1.0 2.7e-05 23.7 0.2 2.0 2 0 0 2 2 2 1 Homeobox KN domain HA PF03457.9 AMD20940.1 - 0.062 13.4 0.2 0.082 13.0 0.1 1.2 1 0 0 1 1 1 0 Helicase associated domain WD40 PF00400.27 AMD20942.1 - 0.0047 16.7 1.1 1.3 9.0 0.1 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Sld5 PF05916.6 AMD20943.1 - 1.7e-14 53.9 1.2 1.7e-14 53.9 0.8 1.7 2 0 0 2 2 2 1 GINS complex protein Herpes_UL46 PF03387.9 AMD20943.1 - 0.046 11.9 0.1 0.06 11.5 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL46 protein Peptidase_M16_C PF05193.16 AMD20944.1 - 1.8e-20 73.3 0.1 2.3e-18 66.5 0.0 3.5 4 0 0 4 4 4 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 AMD20944.1 - 3.3e-10 39.8 0.0 1.4e-09 37.9 0.0 2.1 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Tbf5 PF06331.7 AMD20944.1 - 0.035 13.8 0.2 6.2 6.6 0.0 3.0 2 1 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 DUF1949 PF09186.6 AMD20944.1 - 0.065 12.8 0.0 7 6.3 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1949) DUF479 PF04336.7 AMD20944.1 - 0.16 12.0 1.3 0.6 10.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF479 Pkinase PF00069.20 AMD20945.1 - 9.9e-66 221.5 0.1 1.8e-65 220.7 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD20945.1 - 7.2e-33 113.7 0.0 1.3e-32 112.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD20945.1 - 7.7e-10 38.2 0.0 1.3e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD20945.1 - 8.3e-07 28.2 0.5 1.8e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD20945.1 - 0.026 14.2 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Reprolysin_3 PF13582.1 AMD20945.1 - 1.9 9.0 6.2 22 5.5 0.0 3.4 3 0 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like DUF1493 PF07377.7 AMD20946.1 - 0.0067 16.5 1.9 0.15 12.1 0.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1493) SPT2 PF08243.6 AMD20946.1 - 0.011 16.0 0.8 0.023 15.0 0.1 1.8 2 0 0 2 2 2 0 SPT2 chromatin protein DUF3748 PF12566.3 AMD20946.1 - 0.015 15.1 0.1 0.025 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) HlyIII PF03006.15 AMD20947.1 - 1.5e-52 178.2 23.6 1.8e-52 177.9 16.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related PTS_2-RNA PF01885.11 AMD20949.1 - 2.7e-51 173.5 1.9 3.7e-51 173.0 1.3 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family La PF05383.12 AMD20949.1 - 0.036 13.8 0.0 0.077 12.7 0.0 1.6 1 0 0 1 1 1 0 La domain CNH PF00780.17 AMD20951.1 - 2.3e-05 23.9 0.7 0.00015 21.3 0.2 2.3 1 1 1 2 2 2 1 CNH domain CPL PF08144.6 AMD20952.1 - 8.5e-19 67.8 1.0 5.5e-16 58.7 0.0 4.2 5 1 0 5 5 5 1 CPL (NUC119) domain PUF PF00806.14 AMD20952.1 - 3.3e-07 29.4 3.7 0.22 11.0 0.0 5.8 6 0 0 6 6 6 3 Pumilio-family RNA binding repeat Nop14 PF04147.7 AMD20952.1 - 1.8 6.3 22.6 3.9 5.2 15.7 1.5 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 AMD20952.1 - 5.1 5.4 19.2 8.6 4.6 13.3 1.3 1 0 0 1 1 1 0 Daxx Family Sugar_tr PF00083.19 AMD20953.1 - 9.6e-133 443.0 30.3 1.1e-132 442.8 21.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD20953.1 - 9.4e-33 113.3 33.8 9.4e-31 106.7 17.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 AMD20953.1 - 3.5e-07 28.8 4.8 5.9e-07 28.0 3.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 AMD20953.1 - 0.00024 19.3 1.5 0.00024 19.3 1.0 2.2 2 0 0 2 2 2 1 Transmembrane secretion effector Sec20 PF03908.8 AMD20954.1 - 3e-22 78.1 2.1 8.4e-22 76.6 1.5 1.8 1 0 0 1 1 1 1 Sec20 DUF4263 PF14082.1 AMD20954.1 - 0.071 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4263) Cep57_MT_bd PF06657.8 AMD20954.1 - 0.089 12.7 0.2 0.089 12.7 0.1 2.8 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Synaptobrevin PF00957.16 AMD20954.1 - 0.096 12.3 0.5 0.26 10.9 0.4 1.7 1 0 0 1 1 1 0 Synaptobrevin DUF678 PF05077.7 AMD20955.1 - 0.00064 19.6 0.3 0.49 10.4 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF678) Utp12 PF04003.7 AMD20955.1 - 0.0025 17.6 2.2 0.0031 17.3 0.8 1.7 2 0 0 2 2 2 1 Dip2/Utp12 Family DUF4230 PF14014.1 AMD20955.1 - 0.088 12.6 2.3 0.26 11.1 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4230) Pribosyltran PF00156.22 AMD20956.1 - 6.2e-14 51.7 0.3 4.9e-13 48.8 0.2 2.0 1 1 0 1 1 1 1 Phosphoribosyl transferase domain vWA-TerF-like PF10138.4 AMD20956.1 - 0.032 14.0 0.0 0.074 12.8 0.0 1.5 1 1 1 2 2 2 0 vWA found in TerF C terminus CCDC92 PF14916.1 AMD20956.1 - 0.095 12.3 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain of unknown function TMF_TATA_bd PF12325.3 AMD20957.1 - 2.4e-30 104.7 14.5 2.4e-30 104.7 10.0 6.0 2 1 4 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 AMD20957.1 - 9.2e-10 38.2 14.3 9.2e-10 38.2 9.9 8.3 2 2 7 9 9 9 2 TATA element modulatory factor 1 DNA binding DUF869 PF05911.6 AMD20957.1 - 0.00014 20.2 21.7 0.00014 20.2 15.0 3.2 2 1 1 3 3 3 2 Plant protein of unknown function (DUF869) Spc7 PF08317.6 AMD20957.1 - 0.0032 16.1 27.0 0.0032 16.1 18.7 3.5 2 1 0 3 3 3 1 Spc7 kinetochore protein Reo_sigmaC PF04582.7 AMD20957.1 - 0.0048 16.1 22.9 0.0061 15.7 1.5 3.4 2 1 1 3 3 3 2 Reovirus sigma C capsid protein DUF3584 PF12128.3 AMD20957.1 - 0.0091 13.3 59.9 0.0013 16.1 28.4 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF3584) IncA PF04156.9 AMD20957.1 - 1.4 8.5 85.6 0.025 14.1 10.9 5.6 2 1 3 5 5 5 0 IncA protein DUF948 PF06103.6 AMD20957.1 - 4.3 7.2 23.9 0.084 12.7 2.2 4.5 4 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.7 AMD20957.1 - 5.3 6.8 36.7 0.31 10.8 4.5 5.7 3 3 2 5 5 5 0 Protein of unknown function (DUF1664) DUF745 PF05335.8 AMD20957.1 - 7.6 6.0 34.3 0.81 9.1 1.5 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF745) IFT57 PF10498.4 AMD20957.1 - 8.1 5.0 63.7 0.33 9.6 8.4 4.4 2 1 2 4 4 4 0 Intra-flagellar transport protein 57 RIX1 PF08167.7 AMD20958.1 - 2.3e-44 150.9 1.5 6.7e-44 149.4 1.0 1.9 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis FAM176 PF14851.1 AMD20958.1 - 0.16 11.6 7.3 0.19 11.3 3.0 2.2 2 0 0 2 2 2 0 FAM176 family zf-Tim10_DDP PF02953.10 AMD20960.1 - 1.6e-20 72.1 2.0 2e-20 71.8 1.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 AMD20960.1 - 0.038 13.4 2.9 0.062 12.7 2.0 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) DUF2454 PF10521.4 AMD20961.1 - 6.4e-53 179.5 2.6 8.5e-53 179.1 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) Chalcone PF02431.10 AMD20962.1 - 5.9e-48 162.9 0.0 7.3e-48 162.5 0.0 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase NIR_SIR PF01077.17 AMD20963.1 - 6.5e-49 165.3 0.0 2.7e-44 150.3 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 AMD20963.1 - 3.5e-26 90.6 0.1 1e-12 47.4 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.20 AMD20963.1 - 1.1e-24 87.0 0.0 2.2e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin VWA_2 PF13519.1 AMD20964.1 - 3.4e-09 37.0 0.0 5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 AMD20964.1 - 2.6e-05 23.9 0.1 3.7e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.15 AMD20964.1 - 0.028 13.9 1.5 0.072 12.7 1.1 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF3608 PF12257.3 AMD20965.1 - 1.5e-136 453.8 1.4 2.5e-136 453.1 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 AMD20965.1 - 3.4e-25 87.5 0.2 8e-25 86.3 0.2 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Homoserine_dh PF00742.14 AMD20966.1 - 4.2e-51 173.1 0.0 5.5e-51 172.7 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 AMD20966.1 - 1e-18 67.8 0.0 1.7e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 AMD20966.1 - 0.00059 20.1 0.0 0.0017 18.6 0.0 1.7 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.12 AMD20966.1 - 0.0015 18.9 0.0 0.0043 17.4 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 AMD20966.1 - 0.092 12.7 0.0 0.77 9.7 0.0 2.4 3 0 0 3 3 3 0 TrkA-N domain Nif11 PF07862.6 AMD20966.1 - 0.34 10.8 1.3 13 5.8 0.0 3.1 4 0 0 4 4 4 0 Nitrogen fixation protein of unknown function HECT_2 PF09814.4 AMD20968.1 - 1.8e-70 237.4 0.1 2.1e-70 237.2 0.1 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding rOmpB PF12334.3 AMD20968.1 - 0.021 14.1 0.2 0.04 13.2 0.1 1.4 1 0 0 1 1 1 0 Rickettsia outer membrane protein B DHHA2 PF02833.9 AMD20969.1 - 3.7e-19 69.1 0.1 6.5e-19 68.3 0.1 1.4 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.15 AMD20969.1 - 1.2e-10 41.1 0.0 2.4e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 DHH family NUDIX PF00293.23 AMD20970.1 - 3.2e-06 26.8 0.0 6.4e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain PMT PF02366.13 AMD20971.1 - 2.6e-79 266.0 22.5 2.6e-79 266.0 15.6 1.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 AMD20971.1 - 1.2e-25 90.2 1.3 2e-25 89.4 0.3 1.8 2 0 0 2 2 2 1 MIR domain Mgm101p PF06420.7 AMD20972.1 - 1e-89 298.3 0.0 1.4e-89 297.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 tRNA-synt_2b PF00587.20 AMD20974.1 - 4.5e-36 124.0 0.4 1.2e-35 122.5 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 AMD20974.1 - 2.8e-23 81.9 11.2 2.8e-23 81.9 7.7 2.0 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DUF342 PF03961.8 AMD20974.1 - 0.025 13.0 5.2 0.038 12.4 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Occludin_ELL PF07303.8 AMD20974.1 - 2.2 9.0 10.9 0.17 12.6 2.9 2.4 3 0 0 3 3 3 0 Occludin homology domain Ribosomal_S17 PF00366.15 AMD20976.1 - 7.2e-31 106.0 3.0 1.1e-30 105.3 2.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Imm20 PF15568.1 AMD20976.1 - 0.065 13.1 0.1 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 20 Myb_DNA-binding PF00249.26 AMD20977.1 - 2.8e-19 68.8 15.0 1.9e-09 37.4 0.5 5.7 5 1 0 5 5 5 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD20977.1 - 1.6e-18 66.5 20.2 4.8e-15 55.3 1.6 4.3 3 2 1 4 4 4 2 Myb-like DNA-binding domain DUF3895 PF13034.1 AMD20977.1 - 0.052 13.0 0.2 0.63 9.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3895) MADF_DNA_bdg PF10545.4 AMD20977.1 - 0.092 12.9 11.5 0.49 10.6 0.6 4.0 2 2 1 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.1 AMD20977.1 - 7.1 6.8 20.7 0.2 11.8 0.8 5.2 4 2 2 6 6 6 0 Myb/SANT-like DNA-binding domain Vps54 PF07928.7 AMD20978.1 - 0.0012 19.0 7.5 0.0015 18.6 0.6 3.4 3 1 0 3 3 3 1 Vps54-like protein PP1_inhibitor PF05361.7 AMD20978.1 - 0.0015 18.2 2.0 0.0016 18.1 0.1 2.1 2 0 0 2 2 2 1 PKC-activated protein phosphatase-1 inhibitor DASH_Dad4 PF08650.5 AMD20978.1 - 0.01 15.7 1.4 3.6 7.5 0.1 3.0 2 0 0 2 2 2 0 DASH complex subunit Dad4 Pex2_Pex12 PF04757.9 AMD20979.1 - 6e-17 61.8 12.2 1.5e-16 60.5 8.4 1.6 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region RALF PF05498.6 AMD20979.1 - 0.018 15.8 1.2 0.031 15.0 0.9 1.4 1 0 0 1 1 1 0 Rapid ALkalinization Factor (RALF) zinc_ribbon_2 PF13240.1 AMD20979.1 - 0.031 13.7 0.9 0.095 12.2 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF2593 PF10767.4 AMD20979.1 - 0.11 12.1 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2593) zf-ribbon_3 PF13248.1 AMD20979.1 - 0.12 11.5 0.2 0.12 11.5 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4_2 PF13923.1 AMD20979.1 - 1.8 8.6 14.8 1.5 8.8 7.3 2.6 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF1752 PF08550.5 AMD20980.1 - 3.7e-09 36.0 1.7 3.7e-09 36.0 1.2 1.9 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) WD40 PF00400.27 AMD20981.1 - 1.2e-11 44.0 5.8 0.0079 16.0 0.0 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat CHCH PF06747.8 AMD20982.1 - 3e-08 33.3 15.1 8.8e-05 22.3 2.8 2.4 2 0 0 2 2 2 2 CHCH domain COX6B PF02297.12 AMD20982.1 - 5.1e-05 23.2 10.7 0.0037 17.2 0.7 2.1 1 1 1 2 2 2 2 Cytochrome oxidase c subunit VIb Cmc1 PF08583.5 AMD20982.1 - 0.00039 20.1 13.5 0.078 12.7 1.3 3.0 1 1 2 3 3 3 2 Cytochrome c oxidase biogenesis protein Cmc1 like DB PF01682.14 AMD20982.1 - 0.0041 17.0 11.5 0.0083 16.1 5.7 2.1 1 1 1 2 2 2 1 DB module UPF0203 PF05254.7 AMD20982.1 - 0.0068 16.2 9.3 0.13 12.1 3.0 3.1 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.11 AMD20982.1 - 0.024 14.5 8.4 0.15 12.0 0.4 2.9 1 1 2 3 3 3 0 Ubiquinol-cytochrome C reductase hinge protein Pet191_N PF10203.4 AMD20982.1 - 0.066 13.2 12.2 0.34 10.9 5.6 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DUF1903 PF08991.5 AMD20982.1 - 0.069 13.3 11.1 0.15 12.2 0.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1903) Med2 PF11214.3 AMD20982.1 - 0.1 12.6 0.2 0.12 12.4 0.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 2 ALMT PF11744.3 AMD20982.1 - 0.18 10.4 1.2 0.35 9.4 0.8 1.4 1 1 0 1 1 1 0 Aluminium activated malate transporter GCK PF07802.6 AMD20982.1 - 0.47 10.6 10.7 2.9 8.1 2.6 2.3 1 1 1 2 2 2 0 GCK domain SGL PF08450.7 AMD20983.1 - 3.6e-60 203.3 0.0 4.5e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.15 AMD20983.1 - 1.2e-05 25.2 0.4 0.13 12.3 0.0 3.9 4 0 0 4 4 4 2 Arylesterase Transposase_23 PF03017.9 AMD20983.1 - 0.023 14.2 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 TNP1/EN/SPM transposase Str_synth PF03088.11 AMD20983.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Strictosidine synthase PRP1_N PF06424.7 AMD20985.1 - 1.5e-30 106.2 0.2 4e-30 104.8 0.2 1.8 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 AMD20985.1 - 2.5e-25 86.6 2.0 0.0014 19.1 0.0 9.5 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_11 PF13414.1 AMD20985.1 - 2.3e-15 55.9 1.9 0.0006 19.3 0.0 6.7 4 1 1 6 6 6 2 TPR repeat TPR_16 PF13432.1 AMD20985.1 - 8.4e-15 54.9 0.0 0.00058 20.4 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 AMD20985.1 - 1.9e-13 50.5 7.4 3.5e-05 24.0 0.0 6.4 6 2 1 7 7 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 AMD20985.1 - 5.3e-09 35.3 0.2 0.018 14.9 0.0 6.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 AMD20985.1 - 1.6e-08 34.4 0.8 0.074 13.5 0.0 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat Suf PF05843.9 AMD20985.1 - 4.4e-07 29.9 7.2 0.052 13.2 0.1 4.7 3 2 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_15 PF13429.1 AMD20985.1 - 2.6e-06 26.7 16.8 0.069 12.2 0.2 6.3 3 2 2 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 AMD20985.1 - 8.2e-06 25.6 5.3 0.24 11.3 0.0 4.9 4 2 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 AMD20985.1 - 2.5e-05 24.1 1.0 6.9 7.1 0.0 7.1 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD20985.1 - 0.00046 19.7 0.0 2.9 7.8 0.0 4.3 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 AMD20985.1 - 0.0059 16.1 0.0 0.068 12.8 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 AMD20985.1 - 0.01 15.9 4.1 1.2 9.3 0.3 3.6 3 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 AMD20985.1 - 0.03 14.1 1.1 3.6 7.4 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Cellulase PF00150.13 AMD20986.1 - 3.2e-08 33.1 0.9 3.2e-08 33.1 0.6 1.6 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DAHP_synth_1 PF00793.15 AMD20987.1 - 1.4e-96 322.3 0.0 1.7e-96 322.0 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family DUF342 PF03961.8 AMD20988.1 - 7.8 4.7 16.9 3.9 5.7 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Aminotran_1_2 PF00155.16 AMD20989.1 - 2.7e-74 250.3 0.0 3.3e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 AMD20989.1 - 3.6e-06 25.5 0.0 5.6e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 AMD20989.1 - 8.3e-06 25.1 0.1 2.6e-05 23.5 0.1 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 AMD20989.1 - 1.4e-05 24.0 0.1 4.5e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Reticulon PF02453.12 AMD20990.1 - 4.2e-37 127.3 1.4 5.5e-37 126.9 1.0 1.1 1 0 0 1 1 1 1 Reticulon Aconitase PF00330.15 AMD20991.1 - 1.3e-73 248.0 0.0 1.4e-49 168.8 0.0 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 AMD20991.1 - 7.1e-29 100.5 0.0 1.3e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Porphobil_deam PF01379.15 AMD20992.1 - 3e-87 291.0 0.0 4e-87 290.6 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 AMD20992.1 - 3.4e-19 68.7 0.1 5.8e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain DUF1938 PF09153.5 AMD20992.1 - 0.026 14.3 0.2 4.7 7.0 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1938) Flavokinase PF01687.12 AMD20994.1 - 4.2e-33 113.9 0.0 5.3e-33 113.5 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase GLE1 PF07817.8 AMD20995.1 - 2.4e-83 278.9 0.0 2.4e-83 278.9 0.0 2.2 2 0 0 2 2 2 1 GLE1-like protein Activator_LAG-3 PF11498.3 AMD20995.1 - 0.0038 16.0 12.6 0.0056 15.4 8.7 1.3 1 0 0 1 1 1 1 Transcriptional activator LAG-3 DUF966 PF06136.8 AMD20995.1 - 0.13 11.6 10.3 0.19 11.1 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Asp-B-Hydro_N PF05279.6 AMD20995.1 - 0.13 12.0 19.1 0.2 11.4 13.2 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PLRV_ORF5 PF01690.12 AMD20995.1 - 0.76 8.8 11.3 0.99 8.4 7.9 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DDHD PF02862.12 AMD20995.1 - 3.7 7.2 10.1 6 6.6 7.0 1.4 1 0 0 1 1 1 0 DDHD domain Ribosomal_L5_C PF00673.16 AMD20996.1 - 1.6e-19 69.4 0.0 2.5e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 AMD20996.1 - 0.00092 18.9 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 Adaptin_N PF01602.15 AMD20997.1 - 7.7e-104 347.8 18.7 1.2e-103 347.2 12.5 1.5 1 1 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 AMD20997.1 - 1.1e-58 196.5 0.0 3.7e-58 194.8 0.0 2.0 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 AMD20997.1 - 4.5e-49 165.7 0.7 3.4e-48 162.8 0.0 2.5 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 AMD20997.1 - 1.2e-09 38.2 3.5 0.00035 20.7 0.0 4.8 3 1 1 4 4 4 3 HEAT repeats AP4E_app_platf PF14807.1 AMD20997.1 - 0.027 14.6 0.2 0.14 12.3 0.0 2.4 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform Vac14_Fab1_bd PF12755.2 AMD20997.1 - 0.037 14.3 0.1 0.2 12.0 0.1 2.3 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 AMD20997.1 - 0.15 12.6 0.6 84 3.8 0.0 4.6 5 1 0 5 5 5 0 HEAT-like repeat Swi5 PF07061.6 AMD20999.1 - 0.075 12.8 0.0 0.45 10.3 0.1 2.2 2 0 0 2 2 2 0 Swi5 Ribosomal_L7Ae PF01248.21 AMD21000.1 - 1e-27 95.4 0.4 1.4e-27 95.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 AMD21000.1 - 0.00021 21.1 0.0 0.00028 20.7 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 MKT1_C PF12246.3 AMD21001.1 - 5.1e-60 202.4 0.4 1.2e-59 201.2 0.4 1.5 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 AMD21001.1 - 7.4e-30 103.1 0.1 2.2e-29 101.6 0.1 1.9 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.12 AMD21001.1 - 5e-18 65.2 0.0 1.9e-17 63.3 0.0 2.0 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 AMD21001.1 - 4e-12 46.0 0.0 1.5e-10 41.0 0.0 3.0 3 0 0 3 3 3 1 XPG I-region OST3_OST6 PF04756.8 AMD21002.1 - 2.7e-19 69.3 6.2 2.7e-19 69.3 4.3 1.6 2 0 0 2 2 2 1 OST3 / OST6 family Thioredoxin_8 PF13905.1 AMD21002.1 - 0.00062 19.8 0.9 0.21 11.7 0.4 3.8 3 1 0 3 3 3 1 Thioredoxin-like Thioredoxin PF00085.15 AMD21002.1 - 0.0078 15.8 0.0 0.034 13.8 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin MscS_TM PF12794.2 AMD21002.1 - 0.027 13.0 2.7 0.091 11.3 0.4 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Thioredoxin_2 PF13098.1 AMD21002.1 - 0.053 13.7 0.1 0.22 11.7 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain MotB_plug PF13677.1 AMD21002.1 - 0.082 12.2 0.0 0.31 10.4 0.0 2.0 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB Colicin_im PF03857.8 AMD21002.1 - 1.1 9.0 6.8 0.24 11.1 0.6 2.2 2 0 0 2 2 2 0 Colicin immunity protein DPM3 PF08285.6 AMD21002.1 - 3.1 7.7 8.6 9.4 6.1 0.3 3.1 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Snapin_Pallidin PF14712.1 AMD21003.1 - 8.4e-06 26.0 1.4 1e-05 25.7 1.0 1.1 1 0 0 1 1 1 1 Snapin/Pallidin NPV_P10 PF05531.7 AMD21003.1 - 0.025 14.8 0.7 0.15 12.3 0.5 2.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein FolB PF02152.13 AMD21003.1 - 0.03 14.4 0.0 0.049 13.7 0.0 1.3 1 0 0 1 1 1 0 Dihydroneopterin aldolase Transposase_22 PF02994.9 AMD21003.1 - 0.051 12.0 0.8 0.056 11.9 0.5 1.0 1 0 0 1 1 1 0 L1 transposable element TBPIP PF07106.8 AMD21003.1 - 0.066 12.7 2.6 0.083 12.4 1.8 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) MIF4G_like_2 PF09090.6 AMD21003.1 - 0.1 11.8 0.9 0.11 11.6 0.6 1.0 1 0 0 1 1 1 0 MIF4G like DUF2762 PF10960.3 AMD21003.1 - 0.16 11.7 1.2 0.25 11.0 0.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2762) C2 PF00168.25 AMD21004.1 - 1.6e-46 156.0 0.6 5e-21 74.3 0.0 4.7 4 0 0 4 4 4 4 C2 domain DNA_topoisoIV PF00521.15 AMD21005.1 - 3e-122 408.5 0.1 3e-122 408.5 0.0 2.0 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 AMD21005.1 - 2.4e-34 118.0 6.4 7e-34 116.5 4.4 1.8 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 AMD21005.1 - 3.7e-13 49.3 0.0 1.6e-12 47.3 0.0 2.1 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.21 AMD21005.1 - 8.5e-10 38.3 0.0 1.9e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mito_carr PF00153.22 AMD21006.1 - 4.6e-48 160.8 8.4 1.1e-19 69.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NDUF_B12 PF08122.7 AMD21006.1 - 0.044 13.5 1.8 2.1 8.1 0.0 2.9 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family NMT1 PF09084.6 AMD21007.1 - 8.4e-78 260.8 0.0 1.1e-77 260.5 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 AMD21007.1 - 5.3e-09 35.8 0.2 1.3e-07 31.2 0.1 2.3 1 1 0 1 1 1 1 NMT1-like family Phosphonate-bd PF12974.2 AMD21007.1 - 0.032 13.5 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein PBP_like PF12727.2 AMD21007.1 - 0.13 11.2 0.0 0.82 8.5 0.0 2.0 2 0 0 2 2 2 0 PBP superfamily domain Cu-oxidase_3 PF07732.10 AMD21008.1 - 6.3e-37 125.9 1.3 1.3e-35 121.6 0.3 3.1 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 AMD21008.1 - 2.7e-35 120.8 10.3 3.4e-33 114.0 0.1 3.7 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 AMD21008.1 - 7.4e-30 103.9 0.4 2.7e-29 102.0 0.0 2.1 2 1 0 2 2 2 1 Multicopper oxidase Phosphoesterase PF04185.9 AMD21009.1 - 1.3e-38 133.1 2.1 3.8e-38 131.6 1.4 1.7 1 1 0 1 1 1 1 Phosphoesterase family SET PF00856.23 AMD21010.1 - 1.1e-08 35.5 0.0 3.1e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 SET domain HTH_Tnp_Tc5 PF03221.11 AMD21011.1 - 2.3e-14 52.9 0.7 6.4e-14 51.5 0.5 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF2392 PF10288.4 AMD21011.1 - 0.033 14.5 0.7 0.46 10.8 0.5 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2392) RRS1 PF04939.7 AMD21011.1 - 0.053 13.0 0.5 0.053 13.0 0.4 1.8 1 1 1 2 2 2 0 Ribosome biogenesis regulatory protein (RRS1) Cofilin_ADF PF00241.15 AMD21012.1 - 2.1e-42 143.9 0.4 2.4e-42 143.8 0.3 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2360 PF10152.4 AMD21013.1 - 0.6 10.3 2.7 4.3 7.6 0.3 2.6 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein (DUF2360) ABC_tran PF00005.22 AMD21014.1 - 1.7e-58 196.7 0.2 4.3e-34 117.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 AMD21014.1 - 1.1e-50 172.6 35.6 1.5e-28 100.0 5.0 4.4 3 1 1 4 4 4 3 ABC transporter transmembrane region AAA_21 PF13304.1 AMD21014.1 - 1.2e-11 45.1 3.4 3.7e-06 27.1 0.1 4.4 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.1 AMD21014.1 - 1.2e-09 38.7 5.1 6.9e-05 23.2 0.4 2.9 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.1 AMD21014.1 - 3.9e-08 32.6 0.4 0.00043 19.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.14 AMD21014.1 - 1e-07 31.4 8.2 0.00021 20.6 0.9 4.4 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain ATP_bind_1 PF03029.12 AMD21014.1 - 3.1e-05 23.6 0.1 1.9 8.0 0.0 3.5 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein Miro PF08477.8 AMD21014.1 - 5e-05 23.7 0.1 0.48 10.9 0.0 3.1 2 0 0 2 2 2 2 Miro-like protein MMR_HSR1 PF01926.18 AMD21014.1 - 0.00018 21.4 0.1 0.053 13.4 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 AMD21014.1 - 0.0002 20.6 2.2 0.38 9.9 0.0 2.9 3 0 0 3 3 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 AMD21014.1 - 0.00029 19.8 0.1 0.15 10.9 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF87 PF01935.12 AMD21014.1 - 0.00079 19.3 1.2 0.76 9.5 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function DUF87 AAA_22 PF13401.1 AMD21014.1 - 0.0012 19.0 0.1 1.9 8.6 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD21014.1 - 0.0015 19.3 0.1 2.9 8.7 0.1 2.9 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 AMD21014.1 - 0.0024 17.3 0.0 1.7 8.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_25 PF13481.1 AMD21014.1 - 0.0026 17.2 0.0 1.1 8.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 AMD21014.1 - 0.0026 16.8 0.1 1.7 7.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin MobB PF03205.9 AMD21014.1 - 0.0037 16.9 1.1 2.5 7.8 0.1 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 AMD21014.1 - 0.0042 16.9 0.2 0.53 10.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 AMD21014.1 - 0.0049 16.8 0.4 3.4 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_10 PF12846.2 AMD21014.1 - 0.0076 15.7 0.1 0.82 9.0 0.0 2.5 2 0 0 2 2 2 1 AAA-like domain AAA_15 PF13175.1 AMD21014.1 - 0.01 14.9 1.6 1.4 7.8 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.1 AMD21014.1 - 0.024 14.9 0.2 6.4 7.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 AMD21014.1 - 0.07 13.0 0.0 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 AMD21014.1 - 0.071 12.9 0.0 11 5.7 0.0 2.7 3 0 0 3 3 2 0 Dynamin family Adeno_IVa2 PF02456.10 AMD21014.1 - 0.085 11.4 0.8 2.8 6.5 0.0 3.0 3 0 0 3 3 3 0 Adenovirus IVa2 protein AAA PF00004.24 AMD21014.1 - 0.087 13.0 0.3 15 5.7 0.0 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 AMD21014.1 - 0.11 12.0 0.7 6.6 6.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain ResIII PF04851.10 AMD21014.1 - 0.14 12.0 0.0 10 5.9 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_24 PF13479.1 AMD21014.1 - 0.19 11.2 0.7 5.8 6.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 AMD21014.1 - 0.38 10.1 3.7 3.8 6.9 0.6 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RRM_1 PF00076.17 AMD21015.1 - 3.1e-18 65.1 4.3 5.1e-11 42.0 0.3 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21015.1 - 9.6e-14 51.1 0.4 1.2e-06 28.4 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21015.1 - 2.8e-06 27.0 0.7 0.0054 16.5 0.1 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) T2SM PF04612.7 AMD21015.1 - 0.018 14.8 0.3 0.031 14.0 0.2 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Phage_gp53 PF11246.3 AMD21015.1 - 0.32 10.4 2.5 3.9 6.8 0.3 2.2 2 0 0 2 2 2 0 Base plate wedge protein 53 Ribosomal_L7Ae PF01248.21 AMD21016.1 - 1.1e-22 79.2 0.3 1.9e-22 78.5 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 AMD21016.1 - 0.0053 16.5 0.1 0.0098 15.7 0.1 1.4 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF349 PF03993.7 AMD21016.1 - 6.1 7.0 9.4 0.092 12.9 0.8 2.2 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) FGGY_C PF02782.11 AMD21017.1 - 1.8e-73 246.4 0.8 6.9e-73 244.4 0.3 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 AMD21017.1 - 1.3e-45 155.6 0.1 9.8e-38 129.8 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain MIP PF00230.15 AMD21018.1 - 4.7e-59 199.6 10.3 6e-59 199.2 7.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein PrgI PF12666.2 AMD21018.1 - 3.2 7.9 7.2 0.76 9.9 1.7 2.4 2 0 0 2 2 2 0 PrgI family protein V-SNARE_C PF12352.3 AMD21019.1 - 1.5e-15 57.0 3.7 1.5e-15 57.0 2.5 2.6 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec34 PF04136.10 AMD21019.1 - 0.0077 15.9 5.3 0.0094 15.6 2.9 1.6 1 1 0 1 1 1 1 Sec34-like family NT5C PF06941.7 AMD21019.1 - 0.021 14.3 0.2 0.35 10.3 0.0 2.2 1 1 0 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) APG6 PF04111.7 AMD21019.1 - 0.024 13.6 14.7 0.1 11.6 4.2 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 EIF4E-T PF10477.4 AMD21019.1 - 0.025 13.3 5.7 0.029 13.1 3.9 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TipAS PF07739.8 AMD21019.1 - 0.039 14.2 0.1 0.072 13.4 0.0 1.4 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain Phage_GPL PF05926.6 AMD21019.1 - 0.039 13.7 0.2 0.12 12.2 0.1 1.8 1 0 0 1 1 1 0 Phage head completion protein (GPL) ATG16 PF08614.6 AMD21019.1 - 0.1 12.4 14.7 0.073 12.8 9.2 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) SGIII PF15467.1 AMD21019.1 - 0.11 11.5 7.3 0.38 9.7 5.0 1.8 1 1 0 1 1 1 0 Secretogranin-3 DUF479 PF04336.7 AMD21019.1 - 0.21 11.7 1.4 2.4 8.2 0.0 2.8 2 2 0 2 2 2 0 Protein of unknown function, DUF479 DUF4611 PF15387.1 AMD21019.1 - 0.27 11.4 2.1 0.32 11.1 0.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) DUF148 PF02520.12 AMD21019.1 - 0.41 10.4 7.3 0.065 13.0 1.8 2.0 2 1 0 2 2 2 0 Domain of unknown function DUF148 FliT PF05400.8 AMD21019.1 - 0.52 10.7 5.3 1.4 9.4 3.6 1.9 1 1 0 1 1 1 0 Flagellar protein FliT zf-C4H2 PF10146.4 AMD21019.1 - 0.62 10.0 7.3 1.5 8.8 4.8 1.7 1 1 1 2 2 2 0 Zinc finger-containing protein DUF948 PF06103.6 AMD21019.1 - 5.7 6.8 5.7 7.6 6.4 0.3 2.6 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Autophagy_act_C PF03987.10 AMD21020.1 - 0.0008 19.5 1.0 0.0015 18.7 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Fer2_3 PF13085.1 AMD21021.1 - 7.2e-34 115.9 0.1 1.3e-33 115.0 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.1 AMD21021.1 - 6.9e-11 42.3 8.9 6.9e-11 42.3 6.2 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 AMD21021.1 - 2e-09 37.3 6.9 2e-09 37.3 4.8 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 AMD21021.1 - 0.00016 22.0 4.3 0.00016 22.0 3.0 2.7 1 1 2 3 3 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.1 AMD21021.1 - 0.00031 20.4 6.6 0.00031 20.4 4.6 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 AMD21021.1 - 0.0021 18.2 10.0 0.028 14.6 0.3 3.3 3 1 0 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.22 AMD21021.1 - 0.0087 15.7 1.1 0.0087 15.7 0.8 2.5 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_15 PF13459.1 AMD21021.1 - 3.1 8.4 7.8 1.1 9.9 0.1 2.6 3 0 0 3 3 3 0 4Fe-4S single cluster domain Fer4_7 PF12838.2 AMD21021.1 - 3.8 7.9 18.5 0.27 11.6 7.3 2.9 1 1 2 3 3 3 0 4Fe-4S dicluster domain DUF1162 PF06650.7 AMD21022.1 - 4.2e-85 285.3 1.0 8.4e-81 271.2 0.0 3.9 3 0 0 3 3 3 3 Protein of unknown function (DUF1162) Chorein_N PF12624.2 AMD21022.1 - 1.2e-39 134.5 0.1 3.3e-39 133.0 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Ecm29 PF13001.2 AMD21023.1 - 1.8e-123 412.7 5.5 1.8e-123 412.7 3.8 2.2 2 0 0 2 2 2 1 Proteasome stabiliser HEAT PF02985.17 AMD21023.1 - 3.4e-13 48.4 1.2 0.0075 16.2 0.0 7.0 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 AMD21023.1 - 0.0001 22.7 1.6 8.5 7.0 0.0 5.8 5 1 1 6 6 6 1 HEAT-like repeat ubiquitin PF00240.18 AMD21024.1 - 1.1e-102 335.4 15.6 6.8e-34 115.0 0.6 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.3 AMD21024.1 - 2e-59 197.1 13.8 2.6e-19 68.6 0.5 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 AMD21024.1 - 6.8e-19 67.9 6.4 9.4e-05 22.6 0.1 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain Telomere_Sde2 PF13019.1 AMD21024.1 - 5.7e-17 61.8 0.8 0.00025 20.7 0.0 3.0 3 0 0 3 3 3 3 Telomere stability and silencing Rad60-SLD_2 PF13881.1 AMD21024.1 - 7.6e-11 41.8 1.2 0.081 12.8 0.0 3.8 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 AMD21024.1 - 1.5e-10 41.0 0.9 0.082 13.0 0.0 3.2 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain DUF2870 PF11069.3 AMD21024.1 - 4.1e-08 33.1 0.0 0.82 9.7 0.0 3.9 3 0 0 3 3 3 3 Protein of unknown function (DUF2870) TUG-UBL1 PF11470.3 AMD21024.1 - 2.2e-05 24.2 2.6 2.9 7.8 0.0 3.2 3 0 0 3 3 3 3 GLUT4 regulating protein TUG FlgD_ig PF13860.1 AMD21024.1 - 0.00048 19.8 2.4 9.5 6.0 0.0 3.3 3 0 0 3 3 3 0 FlgD Ig-like domain Methyltrans_RNA PF04452.9 AMD21024.1 - 0.00085 18.5 0.1 1.2 8.1 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase Plexin_cytopl PF08337.7 AMD21024.1 - 0.00085 17.7 8.1 1.5 7.0 0.2 4.6 4 2 0 4 4 4 2 Plexin cytoplasmic RasGAP domain Big_3_3 PF13750.1 AMD21024.1 - 0.012 15.0 0.0 32 3.9 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) DUF3861 PF12977.2 AMD21024.1 - 0.018 15.0 2.8 33 4.6 0.0 3.4 1 1 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_4 PF13291.1 AMD21024.1 - 0.021 15.1 0.4 70 3.8 0.0 3.2 3 0 0 3 3 3 0 ACT domain GABP-alpha PF11620.3 AMD21024.1 - 0.035 14.0 3.9 27 4.8 0.1 3.1 3 0 0 3 3 3 0 GA-binding protein alpha chain Tash_PEST PF07708.6 AMD21024.1 - 0.039 13.8 19.8 2.6 8.1 1.2 3.4 3 0 0 3 3 3 0 Tash protein PEST motif CTDII PF01556.13 AMD21024.1 - 0.052 13.4 9.1 5.2 7.0 0.2 3.4 1 1 2 3 3 3 0 DnaJ C terminal domain EMG1 PF03587.9 AMD21024.1 - 0.064 12.5 0.9 17 4.6 0.0 2.9 3 0 0 3 3 3 0 EMG1/NEP1 methyltransferase FERM_N PF09379.5 AMD21024.1 - 0.12 12.4 8.7 29 4.8 0.2 4.7 3 3 0 3 3 3 0 FERM N-terminal domain DUF3781 PF12636.2 AMD21024.1 - 0.31 11.0 3.6 72 3.4 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3781) CDC48_2 PF02933.12 AMD21024.1 - 3.6 7.3 7.5 47 3.7 0.1 3.1 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 KID PF02524.9 AMD21024.1 - 7.6 7.1 8.1 2.1e+02 2.7 0.1 4.8 3 0 0 3 3 3 0 KID repeat ENTH PF01417.15 AMD21025.1 - 8.2e-28 96.7 3.9 1.1e-27 96.3 2.7 1.2 1 0 0 1 1 1 1 ENTH domain CCDC155 PF14662.1 AMD21025.1 - 0.0031 17.1 0.1 0.0056 16.2 0.1 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 DUF1539 PF07560.6 AMD21025.1 - 1.1 9.1 5.8 5 7.0 3.1 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) Prp19 PF08606.6 AMD21026.1 - 2.4e-31 107.2 0.3 4.2e-31 106.4 0.2 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.10 AMD21026.1 - 0.0016 18.3 0.1 0.0042 17.0 0.0 1.7 1 0 0 1 1 1 1 U-box domain DUF4221 PF13970.1 AMD21026.1 - 0.0072 15.6 0.6 0.036 13.3 0.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4221) AMPKBI PF04739.10 AMD21026.1 - 0.02 14.7 0.6 0.057 13.2 0.4 1.8 1 0 0 1 1 1 0 5'-AMP-activated protein kinase beta subunit, interation domain Cys_Met_Meta_PP PF01053.15 AMD21027.1 - 3.7e-114 381.0 0.0 4.4e-114 380.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Zn_clus PF00172.13 AMD21028.1 - 3.9e-08 33.0 9.2 3.9e-08 33.0 6.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 AMD21028.1 - 5.9e-05 22.0 1.5 0.00022 20.2 1.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.21 AMD21029.1 - 7.1e-14 51.2 11.4 4.9e-07 29.7 0.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD21029.1 - 1.2e-10 40.9 8.0 5.6e-05 23.1 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AMD21029.1 - 1.7e-09 37.5 4.1 0.00047 20.2 0.3 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 AMD21029.1 - 1.2e-08 34.7 17.3 1.1e-07 31.8 1.5 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.2 AMD21029.1 - 2.9e-06 27.2 3.3 0.028 14.6 0.3 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-BED PF02892.10 AMD21029.1 - 0.00075 19.2 7.8 0.0099 15.6 0.6 2.5 1 1 1 2 2 2 2 BED zinc finger zf-Di19 PF05605.7 AMD21029.1 - 0.0019 18.2 1.5 0.0033 17.5 1.0 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 AMD21029.1 - 0.0026 17.6 3.8 0.0091 15.8 0.1 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-CHCC PF10276.4 AMD21029.1 - 0.0078 16.0 3.3 0.14 12.0 0.2 2.5 2 0 0 2 2 2 1 Zinc-finger domain zf-C2H2_2 PF12756.2 AMD21029.1 - 0.06 13.4 4.0 5 7.2 0.3 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.10 AMD21029.1 - 0.082 12.3 0.5 1.7 8.1 0.0 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.1 AMD21029.1 - 0.096 12.3 7.7 1.6 8.5 0.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-DBF PF07535.7 AMD21029.1 - 0.24 11.0 2.7 13 5.5 0.2 2.5 2 0 0 2 2 2 0 DBF zinc finger Mnd1 PF03962.10 AMD21030.1 - 5.9e-46 156.4 9.5 7.5e-46 156.1 6.6 1.1 1 0 0 1 1 1 1 Mnd1 family Alpha-2-MRAP_N PF06400.6 AMD21030.1 - 0.067 12.8 4.1 0.044 13.4 1.0 2.0 2 0 0 2 2 2 0 Alpha-2-macroglobulin RAP, N-terminal domain Lectin_N PF03954.9 AMD21030.1 - 0.094 12.1 2.6 0.14 11.5 0.4 2.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Occludin_ELL PF07303.8 AMD21030.1 - 0.26 12.0 8.4 3.7 8.3 0.5 3.1 2 1 1 3 3 3 0 Occludin homology domain Syntaxin-6_N PF09177.6 AMD21030.1 - 0.35 11.2 9.4 2 8.8 3.9 3.1 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF1409 PF07197.7 AMD21030.1 - 0.36 10.9 5.6 7.1 6.7 0.4 3.2 3 1 0 3 3 2 0 Protein of unknown function (DUF1409) CENP-F_leu_zip PF10473.4 AMD21030.1 - 0.36 10.6 13.6 0.089 12.6 6.9 1.9 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Nsp1_C PF05064.8 AMD21030.1 - 0.39 10.3 6.0 0.31 10.6 1.4 2.3 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF4206 PF13901.1 AMD21030.1 - 0.41 10.1 4.2 0.3 10.6 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4206) DUF3373 PF11853.3 AMD21030.1 - 0.41 9.1 3.1 0.57 8.6 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Seryl_tRNA_N PF02403.17 AMD21030.1 - 0.48 10.4 10.1 2.6 8.0 1.8 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CALCOCO1 PF07888.6 AMD21030.1 - 0.6 8.3 9.7 0.18 10.0 4.8 1.4 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spectrin PF00435.16 AMD21030.1 - 0.76 10.0 11.6 0.31 11.3 2.6 2.8 2 2 1 4 4 2 0 Spectrin repeat DUF4404 PF14357.1 AMD21030.1 - 1 9.8 6.9 5.7 7.4 1.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) Atg14 PF10186.4 AMD21030.1 - 1.1 8.2 14.1 0.044 12.7 2.8 3.0 2 1 2 4 4 4 0 UV radiation resistance protein and autophagy-related subunit 14 NPV_P10 PF05531.7 AMD21030.1 - 1.1 9.5 4.6 4.1 7.7 0.6 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_23 PF13476.1 AMD21030.1 - 1.3 9.2 11.2 40 4.4 7.8 2.1 1 1 0 1 1 1 0 AAA domain Syntaxin_2 PF14523.1 AMD21030.1 - 1.6 8.7 10.8 2.4 8.2 2.2 2.8 1 1 2 3 3 3 0 Syntaxin-like protein BLOC1_2 PF10046.4 AMD21030.1 - 2 8.6 7.8 1.9 8.7 1.9 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-Q PF13094.1 AMD21030.1 - 2.1 8.3 9.8 0.65 9.9 4.4 1.7 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit ADIP PF11559.3 AMD21030.1 - 2.8 7.8 13.2 2.2 8.1 3.7 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4140 PF13600.1 AMD21030.1 - 3.4 8.1 6.2 14 6.1 0.3 2.8 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.10 AMD21030.1 - 3.8 7.0 12.6 1.3 8.5 0.1 3.4 3 1 1 4 4 4 0 Septum formation initiator Fib_alpha PF08702.5 AMD21030.1 - 7.3 6.7 13.1 7.9 6.6 1.2 3.0 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 AMD21030.1 - 8.6 6.2 14.0 0.82 9.5 1.1 3.0 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ArfGap PF01412.13 AMD21031.1 - 3.8e-29 100.8 0.3 3.8e-29 100.8 0.2 2.6 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf Pkinase PF00069.20 AMD21032.1 - 1.1e-59 201.7 0.0 2.8e-59 200.3 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain DUF3543 PF12063.3 AMD21032.1 - 9.7e-59 198.4 5.4 3.9e-57 193.1 3.7 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase_Tyr PF07714.12 AMD21032.1 - 1e-44 152.5 0.0 1.8e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21032.1 - 0.0078 15.1 0.0 0.12 11.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.20 AMD21033.1 - 4.3e-55 186.6 0.0 1e-54 185.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21033.1 - 5.2e-26 91.2 0.1 7.9e-25 87.4 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21033.1 - 0.00019 20.5 0.0 0.003 16.5 0.0 2.2 1 1 0 1 1 1 1 Kinase-like Vfa1 PF08432.5 AMD21034.1 - 2e-40 138.7 8.1 2.3e-40 138.5 5.6 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 zf-LITAF-like PF10601.4 AMD21034.1 - 0.088 12.6 0.4 0.13 12.0 0.3 1.2 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Sas10_Utp3 PF04000.10 AMD21035.1 - 1.2e-09 38.2 1.4 4.5e-09 36.3 0.1 2.2 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Syntaxin_2 PF14523.1 AMD21035.1 - 0.14 12.2 2.4 1.7 8.7 0.0 2.9 3 0 0 3 3 3 0 Syntaxin-like protein RNase_H2-Ydr279 PF09468.5 AMD21035.1 - 0.33 10.1 5.6 0.22 10.6 1.9 1.9 2 0 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) Ribosomal_S8e PF01201.17 AMD21036.1 - 4.2e-40 136.9 7.2 2.2e-39 134.6 5.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S8e YebF PF13995.1 AMD21036.1 - 0.02 14.8 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 YebF-like protein HPD PF05044.7 AMD21036.1 - 0.089 12.4 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Homeo-prospero domain PUF PF00806.14 AMD21037.1 - 1.3e-54 178.6 34.1 6.5e-08 31.6 0.1 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat HECT PF00632.20 AMD21038.1 - 6.3e-91 304.8 0.0 8.7e-91 304.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 AMD21038.1 - 1.3e-34 117.6 20.5 1.3e-11 44.0 1.4 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.25 AMD21038.1 - 4e-15 55.4 0.2 1e-14 54.1 0.1 1.7 1 0 0 1 1 1 1 C2 domain Abhydrolase_6 PF12697.2 AMD21039.1 - 2e-20 73.6 0.0 2.6e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD21039.1 - 9.5e-06 25.3 0.0 2.3e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AMD21039.1 - 0.0034 17.1 0.0 0.0065 16.2 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 AMD21039.1 - 0.007 15.8 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Whi5 PF08528.6 AMD21040.1 - 3.6e-10 39.1 0.5 7.3e-10 38.1 0.3 1.5 1 0 0 1 1 1 1 Whi5 like LIM PF00412.17 AMD21041.1 - 1.1e-15 57.3 24.8 1.2e-09 38.1 5.0 2.3 2 0 0 2 2 2 2 LIM domain DUF3336 PF11815.3 AMD21042.1 - 1.2e-40 138.3 9.7 3.3e-40 136.9 6.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 AMD21042.1 - 1.2e-28 100.4 0.0 2.3e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Peptidase_S51 PF03575.12 AMD21042.1 - 0.075 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S51 TPR_11 PF13414.1 AMD21043.1 - 2.4e-06 27.0 3.1 0.0018 17.8 0.2 3.0 2 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 AMD21043.1 - 8.9e-06 25.0 10.4 0.018 14.6 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 AMD21043.1 - 1.8e-05 24.2 4.9 0.3 11.1 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat LRR_4 PF12799.2 AMD21043.1 - 2.2e-05 23.9 11.7 2.5 7.8 0.0 6.2 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) TPR_12 PF13424.1 AMD21043.1 - 0.00014 21.7 3.6 4.6 7.2 0.2 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat F-box PF00646.28 AMD21043.1 - 0.00073 19.1 1.4 0.0038 16.8 0.9 2.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 AMD21043.1 - 0.0022 17.7 0.6 0.011 15.3 0.4 2.3 1 0 0 1 1 1 1 F-box-like Imm43 PF15602.1 AMD21043.1 - 0.016 15.1 0.1 2.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Immunity protein 43 LRR_8 PF13855.1 AMD21043.1 - 0.019 14.7 1.5 0.019 14.7 1.0 5.4 5 1 2 7 7 7 0 Leucine rich repeat MIT PF04212.13 AMD21043.1 - 0.096 12.5 0.7 8.4 6.3 0.1 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 AMD21043.1 - 1 9.3 6.5 6.7 6.7 0.0 3.8 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 AMD21043.1 - 1.6 8.6 11.4 0.1 12.4 0.7 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_6 PF13516.1 AMD21043.1 - 2.5 8.4 13.4 40 4.7 0.0 6.5 7 0 0 7 7 7 0 Leucine Rich repeat Zip PF02535.17 AMD21044.1 - 1.6e-28 99.6 14.7 3.3e-15 55.9 5.6 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter U3_snoRNA_assoc PF08297.6 AMD21045.1 - 1.7e-19 69.8 8.4 1.7e-19 69.8 5.8 2.9 2 1 0 2 2 2 1 U3 snoRNA associated YodL PF14191.1 AMD21045.1 - 0.58 10.6 4.5 0.8 10.2 2.5 1.7 1 1 0 1 1 1 0 YodL-like SNARE_assoc PF09335.6 AMD21047.1 - 4.9e-14 52.5 13.2 3.7e-13 49.7 5.4 3.0 2 1 1 3 3 3 2 SNARE associated Golgi protein VHP PF02209.14 AMD21047.1 - 0.27 10.9 3.7 3.4 7.4 0.4 2.5 2 0 0 2 2 2 0 Villin headpiece domain DUF2207 PF09972.4 AMD21047.1 - 1.3 7.4 10.2 0.26 9.8 4.2 1.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Kin17_mid PF10357.4 AMD21048.1 - 1.1e-41 141.4 6.4 1.7e-41 140.8 4.5 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 AMD21048.1 - 1.7e-05 24.7 1.3 1.7e-05 24.7 0.9 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 AMD21048.1 - 0.0021 18.2 1.4 0.0021 18.2 1.0 2.1 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 AMD21048.1 - 0.0073 16.3 1.0 0.0073 16.3 0.7 2.5 2 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) TFIID_90kDa PF04494.10 AMD21048.1 - 0.0073 16.3 1.6 0.0073 16.3 1.1 1.8 2 0 0 2 2 2 1 WD40 associated region in TFIID subunit AKAP95 PF04988.7 AMD21048.1 - 0.23 11.2 6.7 0.088 12.5 2.5 1.8 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) Peptidase_M48 PF01435.13 AMD21049.1 - 5.1e-23 81.8 0.0 1e-22 80.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M48 HA2 PF04408.18 AMD21050.1 - 4.6e-27 94.0 0.0 3.7e-26 91.1 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 AMD21050.1 - 3.3e-20 72.0 0.4 9.6e-20 70.5 0.0 1.9 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 AMD21050.1 - 6.6e-13 48.3 0.0 1.5e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AMD21050.1 - 9.8e-07 28.4 0.0 2.2e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 AMD21050.1 - 7e-05 22.9 0.0 0.00023 21.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 AMD21050.1 - 0.0012 18.7 0.1 0.97 9.2 0.0 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit T2SE PF00437.15 AMD21050.1 - 0.006 15.5 0.0 0.013 14.4 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein KaiC PF06745.8 AMD21050.1 - 0.021 13.9 0.1 0.056 12.5 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_10 PF12846.2 AMD21050.1 - 0.024 14.0 0.3 0.73 9.2 0.0 3.0 3 0 0 3 3 3 0 AAA-like domain Flavi_DEAD PF07652.9 AMD21050.1 - 0.024 14.3 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_14 PF13173.1 AMD21050.1 - 0.052 13.4 0.7 0.86 9.5 0.5 2.9 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 AMD21050.1 - 0.063 13.0 0.0 0.19 11.5 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 AMD21050.1 - 0.082 12.3 0.4 4.5 6.6 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.1 AMD21050.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain MRP-L20 PF12824.2 AMD21051.1 - 5e-46 156.6 3.3 6e-46 156.4 2.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_3 PF01381.17 AMD21051.1 - 0.014 15.2 0.1 0.32 10.8 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix Frankia_peptide PF14407.1 AMD21051.1 - 0.026 14.2 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. GTP_EFTU PF00009.22 AMD21053.1 - 3.7e-42 143.8 0.0 6.2e-42 143.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.5 AMD21053.1 - 7e-12 45.2 5.6 1.6e-11 44.1 3.9 1.6 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.18 AMD21053.1 - 2.2e-05 24.3 0.0 6.7e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 AMD21053.1 - 4.5e-05 23.4 0.0 0.0001 22.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.12 AMD21053.1 - 0.0045 17.1 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D4 PF14578.1 AMD21053.1 - 0.0068 16.0 0.0 0.017 14.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Arf PF00025.16 AMD21053.1 - 0.008 15.4 0.2 3 7.0 0.0 2.6 3 0 0 3 3 3 2 ADP-ribosylation factor family Invasin_D3 PF09134.5 AMD21053.1 - 0.062 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Invasin, domain 3 FeoB_N PF02421.13 AMD21053.1 - 0.082 12.1 0.1 0.98 8.6 0.0 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B tRNA-synt_2c PF01411.14 AMD21054.1 - 1.5e-222 739.7 0.3 6.7e-222 737.6 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 AMD21054.1 - 2.3e-19 69.0 0.1 7.1e-19 67.4 0.0 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 AMD21054.1 - 1.7e-08 34.0 2.4 4e-08 32.8 1.7 1.7 1 0 0 1 1 1 1 DHHA1 domain FKBP_N PF01346.13 AMD21054.1 - 0.4 10.7 5.8 1.3 9.0 1.8 2.7 3 0 0 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase UDP-g_GGTase PF06427.6 AMD21055.1 - 4.3e-08 32.7 0.2 1.8e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 UDP-glucose:Glycoprotein Glucosyltransferase CUE PF02845.11 AMD21055.1 - 0.00068 19.0 0.5 0.02 14.3 0.0 3.4 4 0 0 4 4 4 1 CUE domain Fungal_trans PF04082.13 AMD21056.1 - 1.3e-18 66.7 0.4 5.6e-17 61.4 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD21056.1 - 2e-07 30.7 11.3 3.4e-07 30.0 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3502 PF12010.3 AMD21056.1 - 0.057 13.3 0.7 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3502) SWIRM PF04433.12 AMD21057.1 - 1.1e-13 51.1 0.0 1.8e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 SWIRM domain Mis12 PF05859.7 AMD21058.1 - 2.8e-39 134.1 0.5 4.7e-39 133.4 0.4 1.4 1 0 0 1 1 1 1 Mis12 protein RAMPs PF03787.10 AMD21058.1 - 0.15 11.9 0.2 0.18 11.5 0.1 1.4 1 1 0 1 1 1 0 RAMP superfamily PK PF00224.16 AMD21059.1 - 7.1e-167 554.3 0.4 9e-167 553.9 0.3 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 AMD21059.1 - 2.2e-28 98.1 0.1 7.4e-28 96.4 0.1 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 AMD21059.1 - 1.1e-06 27.7 0.4 3.2e-06 26.1 0.1 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMS PF00817.15 AMD21060.1 - 1.2e-34 119.2 0.1 2.9e-34 117.9 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family BRCT PF00533.21 AMD21060.1 - 6.5e-11 42.2 0.0 2e-10 40.6 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain IMS_C PF11799.3 AMD21060.1 - 3.6e-10 39.8 0.0 1.2e-09 38.1 0.0 1.9 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain PTCB-BRCT PF12738.2 AMD21060.1 - 6.1e-05 22.7 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain DUF4414 PF14377.1 AMD21060.1 - 0.0039 17.0 0.2 0.0098 15.8 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4414) IMS_HHH PF11798.3 AMD21060.1 - 0.0076 16.2 0.0 0.028 14.4 0.0 2.0 2 0 0 2 2 2 1 IMS family HHH motif HHH_8 PF14716.1 AMD21060.1 - 0.093 12.9 0.0 0.29 11.3 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain HLH PF00010.21 AMD21061.1 - 8.2e-21 73.4 0.1 1.8e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PMSI1 PF15322.1 AMD21061.1 - 0.36 9.8 4.9 0.59 9.1 3.2 1.5 1 1 0 1 1 1 0 Protein missing in infertile sperm 1, putative Neur_chan_memb PF02932.11 AMD21061.1 - 0.61 9.9 5.4 0.94 9.3 3.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.9 AMD21061.1 - 2.9 5.8 11.7 4.1 5.3 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein TGS PF02824.16 AMD21063.1 - 1e-21 76.4 0.0 1.9e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 AMD21063.1 - 5e-17 61.9 0.0 1.3e-16 60.5 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD21063.1 - 5.7e-09 35.4 0.1 1.4e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 AMD21063.1 - 0.0022 17.8 0.2 1.6 8.5 0.0 2.3 1 1 1 2 2 2 2 Dynamin family ArgK PF03308.11 AMD21063.1 - 0.005 15.6 0.1 0.012 14.4 0.1 1.6 2 0 0 2 2 2 1 ArgK protein Miro PF08477.8 AMD21063.1 - 0.012 16.1 0.0 0.027 14.9 0.0 1.7 2 0 0 2 2 2 0 Miro-like protein Arf PF00025.16 AMD21063.1 - 0.071 12.3 0.1 2 7.6 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD21064.1 - 9.1e-33 113.2 0.0 5.3e-32 110.7 0.0 2.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 AMD21064.1 - 6.5e-21 74.2 0.0 2.1e-20 72.6 0.0 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 AMD21064.1 - 1.8e-13 50.3 0.8 2.3e-09 37.2 0.0 3.1 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AMD21064.1 - 4e-06 26.7 2.4 1.1e-05 25.3 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase RNA_pol_Rpb1_5 PF04998.12 AMD21065.1 - 5.7e-99 330.8 0.0 2.9e-98 328.5 0.0 2.2 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 AMD21065.1 - 1.8e-64 216.6 0.1 6e-64 214.9 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 AMD21065.1 - 1.9e-40 138.1 0.8 3.6e-38 130.7 0.0 3.2 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 AMD21065.1 - 6.2e-23 80.5 1.9 1.9e-22 79.0 0.0 3.0 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.7 AMD21065.1 - 5.5e-20 71.8 5.7 5.5e-20 71.8 4.0 4.6 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 1 Fungal_trans PF04082.13 AMD21066.1 - 6.6e-15 54.6 0.2 1.2e-14 53.7 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD21066.1 - 8e-05 22.4 8.7 0.00016 21.4 6.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD-oxidase_C PF02913.14 AMD21066.1 - 0.26 10.5 0.0 0.44 9.8 0.0 1.2 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain SHS2_Rpb7-N PF03876.12 AMD21067.1 - 4.6e-11 42.6 0.0 8.4e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Toxin_5 PF05294.8 AMD21068.1 - 0.13 12.4 0.5 0.3 11.3 0.3 1.6 1 0 0 1 1 1 0 Scorpion short toxin COG6 PF06419.6 AMD21069.1 - 1.3e-151 505.7 23.6 2.1e-151 505.1 16.4 1.2 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Ribosomal_S30AE PF02482.14 AMD21069.1 - 0.014 15.8 0.2 0.36 11.2 0.0 2.7 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Diphthamide_syn PF01866.12 AMD21070.1 - 1.6e-113 379.0 0.1 2.1e-113 378.6 0.1 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein SHQ1 PF04925.10 AMD21071.1 - 7.8e-75 250.4 0.9 1.1e-74 249.9 0.7 1.2 1 0 0 1 1 1 1 SHQ1 protein DUF2722 PF10846.3 AMD21072.1 - 5.6e-28 98.1 12.5 2.3e-26 92.7 8.7 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2722) PRA1 PF03208.14 AMD21073.1 - 4.1e-40 136.6 3.3 4.6e-40 136.4 2.3 1.0 1 0 0 1 1 1 1 PRA1 family protein BNIP3 PF06553.7 AMD21073.1 - 0.093 12.1 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 BNIP3 IncA PF04156.9 AMD21073.1 - 9.4 5.7 11.3 1.4 8.5 0.1 2.9 3 0 0 3 3 3 0 IncA protein Peptidase_M1 PF01433.15 AMD21074.1 - 4.6e-66 223.5 0.0 6.5e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 AMD21074.1 - 4.6e-40 136.5 0.9 8.6e-40 135.6 0.6 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 AMD21074.1 - 2.4e-15 56.6 0.1 4.2e-15 55.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 AMD21074.1 - 2 8.4 4.5 2.7 8.0 1.4 2.5 2 1 0 2 2 2 0 M61 glycyl aminopeptidase PH PF00169.24 AMD21075.1 - 4.3e-14 52.5 0.7 1.1e-13 51.2 0.5 1.8 1 0 0 1 1 1 1 PH domain Glycos_transf_1 PF00534.15 AMD21076.1 - 2.2e-15 56.5 0.0 8.8e-15 54.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 AMD21076.1 - 1.7e-05 24.5 0.6 3.5e-05 23.5 0.0 1.8 3 0 0 3 3 3 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 AMD21076.1 - 0.00029 20.9 0.0 0.00067 19.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Mob1_phocein PF03637.12 AMD21077.1 - 9.1e-69 230.6 0.4 1.1e-68 230.2 0.3 1.1 1 0 0 1 1 1 1 Mob1/phocein family GFO_IDH_MocA PF01408.17 AMD21078.1 - 1.2e-20 74.2 0.3 6.7e-20 71.7 0.1 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 AMD21078.1 - 1.3e-07 31.4 0.0 2.4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DCP1 PF06058.8 AMD21079.1 - 2.7e-18 66.2 0.5 4.5e-10 39.6 0.0 3.0 2 1 1 3 3 3 3 Dcp1-like decapping family Spt20 PF12090.3 AMD21080.1 - 4.1e-52 176.1 9.6 4.1e-52 176.1 6.7 3.7 3 1 0 3 3 3 2 Spt20 family DUF4179 PF13786.1 AMD21080.1 - 0.87 9.8 6.8 0.95 9.7 0.6 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) PEX11 PF05648.9 AMD21081.1 - 1.8e-60 204.0 2.5 2e-60 203.8 1.7 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sld5 PF05916.6 AMD21082.1 - 1.1e-11 44.9 0.0 1.5e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein TPR_11 PF13414.1 AMD21083.1 - 8.1e-28 95.8 18.6 9.7e-07 28.3 0.0 8.8 6 2 2 8 8 8 5 TPR repeat TPR_2 PF07719.12 AMD21083.1 - 1.1e-23 81.1 36.8 5.5e-05 22.7 0.1 12.7 16 0 0 16 16 13 6 Tetratricopeptide repeat TPR_19 PF14559.1 AMD21083.1 - 2.9e-23 81.9 22.1 0.00058 20.1 0.0 10.8 10 2 1 11 11 10 6 Tetratricopeptide repeat TPR_16 PF13432.1 AMD21083.1 - 1.3e-21 76.7 7.0 0.00022 21.8 0.0 9.0 6 1 4 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.23 AMD21083.1 - 1.7e-21 74.8 32.4 6.6e-05 22.3 0.0 11.5 13 0 0 13 13 11 6 Tetratricopeptide repeat TPR_12 PF13424.1 AMD21083.1 - 2.7e-20 72.0 21.2 1.3e-07 31.4 0.0 10.1 6 3 5 11 11 11 4 Tetratricopeptide repeat TPR_14 PF13428.1 AMD21083.1 - 3.6e-17 61.2 16.2 0.0037 17.7 0.0 12.7 13 3 3 16 16 13 3 Tetratricopeptide repeat Apc3 PF12895.2 AMD21083.1 - 6.6e-16 58.2 11.9 3.2e-05 23.9 0.1 6.9 5 2 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 AMD21083.1 - 2.5e-15 55.0 23.2 0.089 12.6 0.0 11.0 10 1 0 10 10 10 5 Tetratricopeptide repeat TPR_6 PF13174.1 AMD21083.1 - 4.4e-08 33.0 24.6 0.24 11.9 0.1 11.1 14 0 0 14 14 9 3 Tetratricopeptide repeat TPR_17 PF13431.1 AMD21083.1 - 3.4e-07 29.9 10.2 18 5.8 0.0 10.9 13 0 0 13 13 11 0 Tetratricopeptide repeat TPR_9 PF13371.1 AMD21083.1 - 5.2e-06 26.2 0.3 0.014 15.2 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 AMD21083.1 - 1.3e-05 24.6 12.2 0.75 9.7 0.0 9.2 10 1 1 11 11 10 2 Tetratricopeptide repeat TPR_10 PF13374.1 AMD21083.1 - 4.9e-05 23.1 14.1 2.3 8.2 0.1 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_3 PF07720.7 AMD21083.1 - 0.0028 17.3 9.3 0.93 9.3 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat PPR PF01535.15 AMD21083.1 - 0.0066 16.3 3.6 1.8 8.6 0.0 5.4 5 0 0 5 5 5 1 PPR repeat GAGA_bind PF06217.7 AMD21083.1 - 3.8 7.3 13.7 11 5.8 9.5 1.8 1 0 0 1 1 1 0 GAGA binding protein-like family RRM_5 PF13893.1 AMD21084.1 - 2.7e-09 36.7 0.2 5.7e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD21084.1 - 7.9e-05 22.2 0.2 0.00019 21.0 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DMRL_synthase PF00885.14 AMD21085.1 - 3.6e-49 166.1 0.2 4.4e-49 165.8 0.2 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Hist_deacetyl PF00850.14 AMD21086.1 - 5.8e-80 268.8 0.1 8.4e-80 268.3 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain AAA PF00004.24 AMD21087.1 - 4.2e-57 192.0 0.0 9.5e-44 148.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 AMD21087.1 - 1.1e-07 32.7 0.0 0.0014 19.4 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 AMD21087.1 - 4.7e-05 23.4 0.1 0.04 13.9 0.0 3.4 2 1 0 3 3 3 1 AAA ATPase domain Parvo_NS1 PF01057.12 AMD21087.1 - 9.2e-05 21.4 0.0 0.00018 20.4 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_25 PF13481.1 AMD21087.1 - 9.9e-05 21.8 0.0 0.0034 16.8 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD21087.1 - 0.00014 21.9 0.0 0.0085 16.2 0.0 3.2 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 AMD21087.1 - 0.00052 20.1 0.0 0.022 14.9 0.0 2.9 2 0 0 2 2 2 1 RNA helicase RuvB_N PF05496.7 AMD21087.1 - 0.00058 18.9 0.0 0.0026 16.8 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 AMD21087.1 - 0.0036 16.7 0.0 0.007 15.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.9 AMD21087.1 - 0.0038 17.1 0.0 0.02 14.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 AMD21087.1 - 0.0049 16.7 0.0 0.25 11.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 AMD21087.1 - 0.0049 17.1 0.0 0.072 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 AMD21087.1 - 0.0052 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 AMD21087.1 - 0.0096 15.7 0.0 0.45 10.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 AMD21087.1 - 0.011 15.4 0.0 0.047 13.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.8 AMD21087.1 - 0.015 14.0 0.0 0.031 13.0 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus Mg_chelatase PF01078.16 AMD21087.1 - 0.015 14.4 0.0 0.052 12.6 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI KaiC PF06745.8 AMD21087.1 - 0.033 13.3 0.0 0.068 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC NACHT PF05729.7 AMD21087.1 - 0.048 13.3 0.1 20 4.8 0.0 3.3 3 0 0 3 3 3 0 NACHT domain AAA_3 PF07726.6 AMD21087.1 - 0.052 13.1 0.0 1.2 8.7 0.0 2.9 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 AMD21087.1 - 0.093 11.9 0.0 0.23 10.6 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.1 AMD21087.1 - 0.095 12.6 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain DnaJ PF00226.26 AMD21088.1 - 3.8e-06 26.5 0.1 6.9e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 AMD21088.1 - 0.025 14.3 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 Pam16 TauD PF02668.11 AMD21088.1 - 0.045 13.4 0.1 0.056 13.1 0.1 1.1 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family zf-DHHC PF01529.15 AMD21090.1 - 5.7e-36 123.5 10.6 5.7e-36 123.5 7.3 1.6 1 1 1 2 2 2 1 DHHC palmitoyltransferase FtsX PF02687.16 AMD21090.1 - 7.4 6.3 12.7 0.071 12.8 2.1 2.3 2 2 0 2 2 2 0 FtsX-like permease family Syja_N PF02383.13 AMD21092.1 - 3e-94 315.3 0.2 3e-94 315.3 0.1 2.1 2 1 0 2 2 2 1 SacI homology domain Peripla_BP_5 PF13433.1 AMD21092.1 - 0.033 12.9 0.1 0.058 12.1 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein domain DUF3533 PF12051.3 AMD21093.1 - 3.4e-112 374.9 6.5 3.9e-112 374.7 4.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) CDC50 PF03381.10 AMD21094.1 - 2.9e-93 312.0 0.8 3.9e-93 311.6 0.6 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family MARVEL PF01284.18 AMD21094.1 - 0.38 10.5 2.9 5.1 6.9 0.2 2.2 2 0 0 2 2 2 0 Membrane-associating domain Keratin_B2_2 PF13885.1 AMD21095.1 - 0.0008 19.0 13.2 0.044 13.5 2.2 3.4 1 1 2 3 3 3 3 Keratin, high sulfur B2 protein ATP_bind_1 PF03029.12 AMD21096.1 - 5.2e-76 255.3 0.0 6.6e-76 254.9 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 AMD21096.1 - 0.00032 20.6 0.0 0.001 19.0 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_10 PF12846.2 AMD21096.1 - 0.0053 16.2 0.0 0.012 15.0 0.0 1.4 1 1 0 1 1 1 1 AAA-like domain AAA_17 PF13207.1 AMD21096.1 - 0.0061 17.3 0.2 0.0061 17.3 0.1 2.7 2 2 0 2 2 2 1 AAA domain MobB PF03205.9 AMD21096.1 - 0.0097 15.6 0.0 2.7 7.6 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 AMD21096.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain ArgK PF03308.11 AMD21096.1 - 0.023 13.4 0.0 0.041 12.6 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_33 PF13671.1 AMD21096.1 - 0.036 13.9 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 AMD21096.1 - 0.051 13.7 0.0 0.17 12.0 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA PF00004.24 AMD21096.1 - 0.055 13.6 0.0 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 AMD21096.1 - 0.085 13.1 2.9 0.97 9.7 0.2 2.5 2 0 0 2 2 2 0 AAA domain MitMem_reg PF13012.1 AMD21097.1 - 6.8e-40 135.7 2.6 7.4e-40 135.6 0.6 1.9 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.16 AMD21097.1 - 4.3e-28 97.3 0.0 1e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UbiA PF01040.13 AMD21098.1 - 1.7e-22 79.9 16.1 1.7e-22 79.8 10.7 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Hexapep PF00132.19 AMD21099.1 - 9.8e-07 28.0 4.7 0.004 16.6 2.0 3.7 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 AMD21099.1 - 5.8e-06 26.4 0.0 8.9e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.18 AMD21099.1 - 0.00013 21.3 0.0 0.00022 20.5 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.7 AMD21099.1 - 0.0086 14.6 1.6 0.064 11.8 0.9 2.1 1 1 1 2 2 2 1 L-fucokinase Hexapep_2 PF14602.1 AMD21099.1 - 0.06 12.9 10.0 0.43 10.1 1.5 3.0 3 0 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase E1-E2_ATPase PF00122.15 AMD21100.1 - 4.5e-66 222.1 6.1 4.5e-66 222.1 4.2 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 AMD21100.1 - 1.6e-31 109.2 6.4 1.6e-31 109.2 4.5 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 AMD21100.1 - 4.1e-29 102.5 0.0 2.5e-25 90.1 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 AMD21100.1 - 2.8e-18 65.6 0.0 5.7e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 AMD21100.1 - 1.5e-17 64.4 0.0 3.5e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 AMD21100.1 - 1.5e-13 49.9 0.8 3.7e-13 48.7 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 AMD21100.1 - 0.0015 18.2 0.1 0.016 14.8 0.3 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2207 PF09972.4 AMD21100.1 - 0.0029 16.2 1.6 0.0029 16.2 1.1 2.4 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) Aminotran_5 PF00266.14 AMD21101.1 - 3.2e-14 52.4 0.0 5e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Zn_clus PF00172.13 AMD21102.1 - 3.2e-10 39.7 7.5 5.3e-10 39.0 5.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 AMD21102.1 - 4.1 7.6 9.7 7.5 6.7 6.7 1.4 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region EST1_DNA_bind PF10373.4 AMD21103.1 - 4.3e-41 140.9 0.7 8.8e-41 139.9 0.0 1.8 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.4 AMD21103.1 - 5.9e-30 103.9 1.8 5.2e-28 97.6 1.0 3.2 3 0 0 3 3 3 1 Telomerase activating protein Est1 TPR_11 PF13414.1 AMD21103.1 - 0.071 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 TPR repeat Topoisom_bac PF01131.15 AMD21104.1 - 2.7e-99 332.7 0.6 3.3e-99 332.4 0.4 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 AMD21104.1 - 9.4e-19 67.2 0.0 2.2e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Toprim domain Cation_efflux PF01545.16 AMD21105.1 - 8.5e-52 175.9 7.3 8.5e-52 175.9 5.1 3.6 3 1 0 3 3 3 2 Cation efflux family Coq4 PF05019.8 AMD21106.1 - 5.7e-93 309.8 0.0 7.3e-93 309.5 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Toprim_4 PF13662.1 AMD21106.1 - 0.039 13.9 0.0 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 Toprim domain DUF569 PF04601.8 AMD21106.1 - 0.044 13.2 0.0 0.18 11.2 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF569) Rogdi_lz PF10259.4 AMD21107.1 - 2.1e-73 246.8 6.1 2.4e-73 246.6 4.2 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Orthopox_F14 PF06076.7 AMD21107.1 - 0.37 10.8 3.4 9.1 6.4 0.0 3.2 3 0 0 3 3 3 0 Orthopoxvirus F14 protein DASH_Spc19 PF08287.6 AMD21108.1 - 6e-41 139.6 10.4 6.7e-41 139.4 7.2 1.0 1 0 0 1 1 1 1 Spc19 Sds3 PF08598.6 AMD21108.1 - 0.00034 20.2 2.4 0.00045 19.7 1.2 1.4 1 1 0 1 1 1 1 Sds3-like DUF3209 PF11483.3 AMD21108.1 - 0.068 13.5 0.7 0.15 12.4 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3209) APG6 PF04111.7 AMD21108.1 - 0.27 10.2 8.2 0.29 10.1 4.8 1.6 1 1 1 2 2 2 0 Autophagy protein Apg6 Mnd1 PF03962.10 AMD21108.1 - 0.47 10.0 5.0 0.47 10.1 2.8 1.5 1 1 0 1 1 1 0 Mnd1 family DASH_Dad2 PF08654.5 AMD21108.1 - 0.5 10.3 8.7 0.2 11.6 2.0 2.6 2 1 0 2 2 2 0 DASH complex subunit Dad2 Prefoldin_2 PF01920.15 AMD21108.1 - 0.53 10.0 9.3 0.6 9.8 0.5 2.4 2 0 0 2 2 2 0 Prefoldin subunit Spc7 PF08317.6 AMD21108.1 - 0.59 8.7 6.4 1.1 7.8 4.5 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF2951 PF11166.3 AMD21108.1 - 0.72 9.7 5.5 0.24 11.2 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2951) DUF4140 PF13600.1 AMD21108.1 - 0.79 10.1 6.6 6.3 7.2 0.3 2.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4515 PF14988.1 AMD21108.1 - 1.1 8.8 12.9 1.1 8.8 7.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4515) CorA PF01544.13 AMD21108.1 - 1.6 7.6 4.9 0.31 10.0 0.8 1.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Med9 PF07544.8 AMD21108.1 - 2.2 8.0 5.8 5.2 6.8 0.2 2.8 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF848 PF05852.6 AMD21108.1 - 2.5 7.9 7.1 0.6 9.9 1.1 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) TMF_TATA_bd PF12325.3 AMD21108.1 - 2.6 7.7 9.3 7.7 6.2 0.5 2.5 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Syntaxin PF00804.20 AMD21108.1 - 4 7.6 7.1 3.4 7.8 1.0 2.3 2 1 0 2 2 2 0 Syntaxin DivIC PF04977.10 AMD21108.1 - 4.2 6.9 9.7 4 7.0 0.4 3.2 2 1 1 3 3 3 0 Septum formation initiator FHA PF00498.21 AMD21109.1 - 2.5e-18 65.9 0.9 8.4e-17 61.0 0.1 3.0 3 0 0 3 3 3 1 FHA domain V_ATPase_I PF01496.14 AMD21109.1 - 0.0018 16.2 5.9 0.0023 15.8 4.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF2894 PF11445.3 AMD21109.1 - 0.019 15.2 3.7 0.035 14.3 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) DUF4407 PF14362.1 AMD21109.1 - 1.2 7.9 5.9 1.8 7.4 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XhlA PF10779.4 AMD21109.1 - 3.5 7.5 8.2 11 5.9 5.6 2.0 1 1 0 1 1 1 0 Haemolysin XhlA LRS4 PF10422.4 AMD21109.1 - 4.1 6.6 15.8 8.3 5.6 10.9 1.5 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Exonuc_VII_L PF02601.10 AMD21109.1 - 5.2 6.1 16.2 7.4 5.6 11.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BPL_LplA_LipB PF03099.14 AMD21110.1 - 1.6e-17 63.6 0.0 2.7e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family SET PF00856.23 AMD21111.1 - 5.6e-05 23.5 0.4 9.8e-05 22.7 0.3 1.7 1 1 0 1 1 1 1 SET domain TetR_C_4 PF08359.6 AMD21111.1 - 0.037 13.9 0.6 7.6 6.4 0.0 2.6 3 0 0 3 3 3 0 YsiA-like protein, C-terminal region MCM_N PF14551.1 AMD21111.1 - 0.063 13.7 0.2 0.17 12.4 0.1 1.7 1 0 0 1 1 1 0 MCM N-terminal domain ApbA_C PF08546.6 AMD21112.1 - 5.4e-16 58.7 0.0 1.1e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 AMD21112.1 - 0.0051 16.2 0.0 0.024 14.0 0.0 2.0 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA CoaE PF01121.15 AMD21113.1 - 3.5e-58 195.9 0.0 5.2e-58 195.4 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 AMD21113.1 - 5e-06 27.3 0.1 1.5e-05 25.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD21113.1 - 2.9e-05 24.3 0.2 0.0005 20.3 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AMD21113.1 - 0.00026 20.8 0.0 0.00064 19.6 0.0 1.8 2 1 0 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.1 AMD21113.1 - 0.0043 16.9 0.0 0.2 11.5 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family Herpes_UL69 PF05459.7 AMD21113.1 - 0.024 13.7 0.1 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus transcriptional regulator family PRK PF00485.13 AMD21113.1 - 0.029 13.9 0.1 0.064 12.8 0.0 1.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family GAS PF13851.1 AMD21114.1 - 0.015 14.4 4.6 0.031 13.4 3.2 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF3665 PF12427.3 AMD21114.1 - 0.025 13.9 1.6 0.047 13.0 0.1 2.3 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase DUF1759 PF03564.10 AMD21114.1 - 0.069 12.9 3.3 5.6 6.7 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) DEAD PF00270.24 AMD21115.1 - 1.7e-39 135.0 0.6 1.2e-37 128.9 0.1 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21115.1 - 3e-21 75.0 0.2 6.6e-21 73.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD21115.1 - 3.5e-07 30.2 0.0 9.9e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 AMD21115.1 - 0.094 12.2 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain cwf21 PF08312.7 AMD21115.1 - 0.4 10.5 2.6 1.2 9.0 0.3 2.7 2 0 0 2 2 2 0 cwf21 domain PI3Ka PF00613.15 AMD21116.1 - 1.1e-64 216.9 3.0 1.9e-64 216.2 2.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 AMD21116.1 - 7.6e-46 156.4 0.1 6.9e-45 153.3 0.0 2.5 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 AMD21116.1 - 8.4e-24 83.9 0.3 2.4e-23 82.5 0.1 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 Closter_coat PF01785.12 AMD21116.1 - 0.018 14.0 0.1 0.048 12.6 0.1 1.7 1 0 0 1 1 1 0 Closterovirus coat protein DUF221 PF02714.10 AMD21117.1 - 3.6e-100 334.9 19.0 3.6e-100 334.9 13.1 1.9 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 AMD21117.1 - 5.3e-39 133.3 2.6 5.3e-39 133.3 1.8 2.4 2 1 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 AMD21117.1 - 4e-13 49.6 0.0 8e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) Arv1 PF04161.8 AMD21118.1 - 2e-71 240.2 14.6 2.8e-71 239.7 10.1 1.2 1 0 0 1 1 1 1 Arv1-like family zf-CCCH PF00642.19 AMD21119.1 - 4e-06 26.3 3.6 6.5e-06 25.6 2.5 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ATP_bind_1 PF03029.12 AMD21120.1 - 8.2e-84 280.8 0.0 9.4e-84 280.6 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 AMD21120.1 - 0.0014 18.1 0.0 0.0039 16.6 0.0 1.7 2 0 0 2 2 2 1 AAA-like domain GTP_EFTU PF00009.22 AMD21120.1 - 0.0022 17.4 0.0 0.49 9.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD21120.1 - 0.006 16.5 0.0 0.015 15.2 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 AMD21120.1 - 0.011 16.5 0.0 0.024 15.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain ArgK PF03308.11 AMD21120.1 - 0.014 14.1 0.1 0.028 13.2 0.0 1.4 2 0 0 2 2 2 0 ArgK protein AAA_24 PF13479.1 AMD21120.1 - 0.029 13.9 0.0 0.16 11.5 0.0 2.2 2 1 1 3 3 3 0 AAA domain AAA_16 PF13191.1 AMD21120.1 - 0.039 13.9 0.0 0.5 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 AMD21120.1 - 0.05 13.7 0.0 0.21 11.7 0.0 2.1 3 0 0 3 3 2 0 RNA helicase Gtr1_RagA PF04670.7 AMD21120.1 - 0.067 12.3 0.0 0.36 9.9 0.0 2.2 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.22 AMD21120.1 - 0.087 13.1 0.0 0.19 12.0 0.0 1.6 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.1 AMD21120.1 - 0.091 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 AMD21120.1 - 0.094 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin KAP_NTPase PF07693.9 AMD21120.1 - 0.094 11.6 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain MobB PF03205.9 AMD21120.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 AMD21120.1 - 0.15 11.1 0.0 0.3 10.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_30 PF13604.1 AMD21120.1 - 0.19 11.2 0.0 0.39 10.2 0.0 1.5 2 0 0 2 2 2 0 AAA domain SIR2 PF02146.12 AMD21121.1 - 3e-31 108.5 0.0 5.4e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TIP49 PF06068.8 AMD21122.1 - 1.2e-189 630.0 0.7 1.4e-189 629.8 0.5 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 AMD21122.1 - 1.2e-08 35.2 1.1 6.5e-05 23.1 0.0 2.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD21122.1 - 1.4e-08 34.1 2.1 0.00092 18.3 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 AMD21122.1 - 0.001 19.1 0.0 0.14 12.1 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 AMD21122.1 - 0.0012 18.7 0.1 0.0027 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD21122.1 - 0.0014 18.2 0.1 0.016 14.9 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain Zeta_toxin PF06414.7 AMD21122.1 - 0.0099 14.9 0.1 0.028 13.5 0.1 1.8 1 0 0 1 1 1 1 Zeta toxin DnaB_C PF03796.10 AMD21122.1 - 0.017 13.9 0.0 0.033 13.0 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Mg_chelatase PF01078.16 AMD21122.1 - 0.023 13.8 0.1 3.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI CPT PF07931.7 AMD21122.1 - 0.03 13.9 0.0 0.081 12.5 0.0 1.8 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Sigma54_activat PF00158.21 AMD21122.1 - 0.052 13.0 0.0 6.9 6.1 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 AMD21122.1 - 0.076 12.4 0.4 0.83 9.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.9 AMD21122.1 - 0.11 12.1 0.3 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Parvo_NS1 PF01057.12 AMD21122.1 - 0.13 11.0 0.0 0.33 9.7 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 MinE PF03776.9 AMD21122.1 - 0.2 11.1 1.8 0.93 9.0 0.1 2.5 2 0 0 2 2 2 0 Septum formation topological specificity factor MinE Sec1 PF00995.18 AMD21123.1 - 9.2e-146 486.7 7.0 1.1e-145 486.5 4.9 1.0 1 0 0 1 1 1 1 Sec1 family Cpn60_TCP1 PF00118.19 AMD21124.1 - 1.3e-145 485.8 1.9 1.4e-145 485.6 1.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mur_ligase_M PF08245.7 AMD21125.1 - 8e-10 39.0 0.4 5.5e-08 33.0 0.0 3.0 2 1 0 2 2 2 1 Mur ligase middle domain Mur_ligase_C PF02875.16 AMD21125.1 - 0.00036 20.4 0.0 0.0008 19.3 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain RRM_5 PF13893.1 AMD21126.1 - 0.00011 22.0 0.0 0.064 13.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD21126.1 - 0.013 15.1 0.0 0.042 13.4 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TruD PF01142.13 AMD21127.1 - 4.8e-64 216.3 0.2 3.4e-58 197.1 0.0 4.5 2 1 2 4 4 4 2 tRNA pseudouridine synthase D (TruD) YhzD PF14120.1 AMD21127.1 - 0.0017 18.1 0.1 0.028 14.2 0.1 2.7 2 0 0 2 2 2 1 YhzD-like protein ABM PF03992.11 AMD21127.1 - 0.021 14.8 0.0 0.062 13.3 0.0 1.8 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase WD40 PF00400.27 AMD21128.1 - 3.2e-47 156.7 14.8 1.5e-11 43.6 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 AMD21128.1 - 6.2e-05 21.9 1.6 1.1 7.8 0.0 4.9 1 1 2 3 3 3 2 Nup133 N terminal like PQQ_2 PF13360.1 AMD21128.1 - 0.011 15.2 0.0 0.25 10.7 0.0 2.4 2 1 0 2 2 2 0 PQQ-like domain eIF2A PF08662.6 AMD21128.1 - 0.076 12.7 0.0 0.81 9.3 0.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A MOZ_SAS PF01853.13 AMD21129.1 - 1e-88 295.5 0.8 1.5e-88 295.0 0.5 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 AMD21129.1 - 4e-22 77.6 0.0 9.1e-22 76.5 0.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_1 PF00583.19 AMD21129.1 - 0.041 13.9 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family PTPA PF03095.10 AMD21130.1 - 6.6e-115 383.3 0.5 8.2e-115 383.0 0.3 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DAGAT PF03982.8 AMD21131.1 - 1.3e-81 273.6 2.9 6.7e-74 248.2 0.1 2.1 1 1 1 2 2 2 2 Diacylglycerol acyltransferase Pkinase PF00069.20 AMD21132.1 - 9.2e-78 260.9 0.0 1.4e-77 260.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21132.1 - 1.4e-37 129.2 0.0 2.3e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 AMD21132.1 - 2.3e-24 85.2 2.1 8.3e-14 51.4 0.1 3.2 3 0 0 3 3 3 2 FHA domain Kinase-like PF14531.1 AMD21132.1 - 5.7e-08 32.0 0.0 1e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD21132.1 - 1.1e-05 25.2 0.0 0.015 15.0 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 AMD21132.1 - 6.9e-05 22.0 0.0 0.00013 21.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 AMD21132.1 - 0.0036 16.6 0.0 0.009 15.3 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Asp PF00026.18 AMD21133.1 - 4.1e-98 328.5 0.0 4.9e-98 328.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 AMD21133.1 - 2e-08 33.9 0.0 2.7e-06 27.0 0.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal TAXi_N PF14543.1 AMD21133.1 - 9.5e-08 32.1 0.0 2.6e-07 30.7 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 AMD21133.1 - 0.00043 20.7 0.0 0.015 15.7 0.0 2.8 3 0 0 3 3 3 1 Aspartyl protease Kinesin PF00225.18 AMD21134.1 - 7.9e-104 346.9 1.1 1.5e-103 346.0 0.8 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF4168 PF13767.1 AMD21134.1 - 1.1 9.9 6.8 32 5.2 4.7 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4168) Fib_alpha PF08702.5 AMD21134.1 - 4.1 7.5 15.5 11 6.1 5.0 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Methyltransf_15 PF09445.5 AMD21136.1 - 6.5e-60 201.4 0.0 8.6e-60 201.0 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 AMD21136.1 - 3e-08 33.6 0.0 4.4e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 AMD21136.1 - 5.5e-07 29.3 0.0 7.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.1 AMD21136.1 - 4.1e-05 23.2 0.0 6.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MethyltransfD12 PF02086.10 AMD21136.1 - 6.2e-05 22.5 0.1 6.2e-05 22.5 0.1 1.6 2 0 0 2 2 2 1 D12 class N6 adenine-specific DNA methyltransferase N6_N4_Mtase PF01555.13 AMD21136.1 - 0.00018 21.0 0.7 0.055 12.9 0.1 2.3 1 1 1 2 2 2 2 DNA methylase Methyltransf_18 PF12847.2 AMD21136.1 - 0.00053 20.5 0.0 0.00092 19.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD21136.1 - 0.0025 18.1 0.0 0.0065 16.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD21136.1 - 0.0031 17.2 0.0 0.0055 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AMD21136.1 - 0.0041 16.5 0.0 0.0062 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 AMD21136.1 - 0.012 14.6 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Met_10 PF02475.11 AMD21136.1 - 0.03 13.9 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Cons_hypoth95 PF03602.10 AMD21136.1 - 0.037 13.4 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Abhydrolase_1 PF00561.15 AMD21138.1 - 4.3e-15 55.8 0.0 6.1e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 AMD21138.1 - 4.6e-10 39.7 0.0 7e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AMD21138.1 - 1.3e-06 28.2 0.0 2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.5 AMD21138.1 - 0.0052 15.7 0.0 0.009 14.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) DUF900 PF05990.7 AMD21138.1 - 0.045 13.0 0.0 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Transpos_assoc PF13963.1 AMD21139.1 - 0.036 14.0 0.0 0.043 13.8 0.0 1.1 1 0 0 1 1 1 0 Transposase-associated domain tRNA-synt_1 PF00133.17 AMD21140.1 - 3.3e-43 147.6 0.0 8.8e-34 116.4 0.0 2.6 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 AMD21140.1 - 1.7e-18 66.4 0.1 1.6e-10 40.2 0.0 3.9 4 0 0 4 4 4 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 AMD21140.1 - 6e-12 45.5 0.0 1.5e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 AMD21140.1 - 9.3e-07 28.2 1.1 1.4e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain adh_short PF00106.20 AMD21141.1 - 8.3e-13 48.5 0.2 1.5e-11 44.5 0.0 2.4 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 AMD21141.1 - 0.00062 19.5 0.0 0.00096 18.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AMD21141.1 - 0.0058 16.3 0.0 0.016 14.9 0.0 1.7 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 AMD21141.1 - 0.061 13.3 0.0 2.8 7.9 0.0 2.7 1 1 1 2 2 2 0 NADH(P)-binding CENP-T PF15511.1 AMD21142.1 - 0.00079 18.7 1.3 0.001 18.4 0.9 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T CobT PF06213.7 AMD21142.1 - 0.0026 16.9 13.9 0.0041 16.3 9.7 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT CDC45 PF02724.9 AMD21142.1 - 0.0098 13.9 6.3 0.014 13.4 4.3 1.2 1 0 0 1 1 1 1 CDC45-like protein Sigma70_ner PF04546.8 AMD21142.1 - 0.11 12.0 16.9 0.23 11.0 11.7 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region NARP1 PF12569.3 AMD21142.1 - 0.26 9.9 8.1 0.6 8.7 5.6 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2722 PF10846.3 AMD21142.1 - 0.61 9.0 3.8 0.88 8.5 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Daxx PF03344.10 AMD21142.1 - 0.65 8.4 18.0 1 7.8 12.5 1.2 1 0 0 1 1 1 0 Daxx Family Paf1 PF03985.8 AMD21142.1 - 0.8 8.3 16.1 1.3 7.6 11.2 1.3 1 0 0 1 1 1 0 Paf1 Pox_Ag35 PF03286.9 AMD21142.1 - 1.3 8.5 11.8 0.97 8.9 6.8 1.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Nop14 PF04147.7 AMD21142.1 - 1.7 6.4 21.9 0.11 10.4 10.7 2.0 2 0 0 2 2 2 0 Nop14-like family FAM176 PF14851.1 AMD21142.1 - 1.9 8.1 8.3 3.8 7.1 5.8 1.4 1 0 0 1 1 1 0 FAM176 family Astro_capsid PF03115.9 AMD21142.1 - 2.9 6.0 4.7 4.1 5.5 3.3 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF1510 PF07423.6 AMD21142.1 - 4.5 6.5 13.6 7.4 5.8 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TRAP_alpha PF03896.11 AMD21142.1 - 7.6 5.4 14.3 13 4.6 9.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.5 AMD21142.1 - 8.5 5.3 14.9 15 4.5 10.3 1.3 1 0 0 1 1 1 0 BUD22 DUF3661 PF12400.3 AMD21143.1 - 1.1e-37 129.0 8.0 1.5e-37 128.5 5.6 1.2 1 0 0 1 1 1 1 Vaculolar membrane protein zf-DHHC PF01529.15 AMD21143.1 - 6.6 6.0 7.5 3.3 7.0 3.3 1.8 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF3661 PF12400.3 AMD21144.1 - 6.1e-43 145.9 9.3 9.1e-43 145.4 6.4 1.3 1 0 0 1 1 1 1 Vaculolar membrane protein HATPase_c_3 PF13589.1 AMD21146.1 - 9.2e-10 38.3 0.0 1.7e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 AMD21146.1 - 1.8e-08 34.0 0.0 3.5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.6 AMD21146.1 - 1.2e-07 31.4 0.0 1.2e-06 28.1 0.0 2.2 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 AMD21146.1 - 0.00086 18.7 0.0 0.0052 16.2 0.0 2.3 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Myc_N PF01056.13 AMD21146.1 - 0.1 11.7 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Apc5 PF12862.2 AMD21147.1 - 3.8e-18 65.0 3.4 4.8e-18 64.7 0.1 2.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 Clp1 PF06807.9 AMD21148.1 - 1.6e-16 60.6 0.0 2.5e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 AAA_16 PF13191.1 AMD21148.1 - 0.00014 21.9 0.0 0.00025 21.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain MobB PF03205.9 AMD21148.1 - 0.0057 16.3 0.0 0.014 15.0 0.0 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 AMD21148.1 - 0.0069 16.6 0.1 0.015 15.5 0.1 1.5 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.18 AMD21148.1 - 0.019 14.9 0.1 0.094 12.6 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.4 AMD21148.1 - 0.02 14.3 0.0 0.054 12.9 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.13 AMD21148.1 - 0.021 14.3 0.2 0.072 12.5 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.1 AMD21148.1 - 0.026 14.8 0.3 0.36 11.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 AMD21148.1 - 0.035 13.6 0.0 0.08 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 AMD21148.1 - 0.045 13.1 0.1 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 AMD21148.1 - 0.1 12.1 0.0 0.18 11.2 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.1 AMD21148.1 - 0.12 12.3 0.1 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 AMD21148.1 - 0.14 13.0 0.1 0.26 12.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain Rhodanese PF00581.15 AMD21149.1 - 3.3e-19 69.3 0.0 4.1e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Myb_DNA-bind_6 PF13921.1 AMD21150.1 - 0.0073 16.3 0.6 0.013 15.5 0.4 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3939 PF13075.1 AMD21150.1 - 0.046 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) DNA_pol_B PF00136.16 AMD21151.1 - 1.5e-89 300.9 0.0 2.1e-89 300.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 AMD21151.1 - 6.3e-17 61.4 0.0 4.6e-08 32.2 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 AMD21151.1 - 4.5e-09 36.1 7.8 8.7e-09 35.2 5.4 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DUF2962 PF11176.3 AMD21152.1 - 1.2e-52 177.5 6.1 1.4e-52 177.3 4.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) MRC1 PF09444.5 AMD21152.1 - 0.026 14.8 5.6 0.04 14.2 3.9 1.3 1 0 0 1 1 1 0 MRC1-like domain FlxA PF14282.1 AMD21153.1 - 0.041 13.8 1.3 0.041 13.8 0.9 3.4 2 1 2 4 4 4 0 FlxA-like protein Acetyltransf_1 PF00583.19 AMD21154.1 - 3.9e-11 42.8 0.0 5.8e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AMD21154.1 - 3.1e-09 36.8 0.0 6.7e-09 35.8 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 AMD21154.1 - 2e-07 31.1 0.0 2.2e-07 30.9 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AMD21154.1 - 5.8e-05 23.0 0.0 5.8e-05 23.0 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 AMD21154.1 - 0.0017 18.0 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Slx4 PF09494.5 AMD21154.1 - 0.016 14.9 0.0 0.1 12.3 0.0 2.1 2 0 0 2 2 2 0 Slx4 endonuclease Acetyltransf_8 PF13523.1 AMD21154.1 - 0.022 14.6 0.0 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sec63 PF02889.11 AMD21155.1 - 6.4e-19 68.3 0.2 2e-17 63.3 0.0 2.1 1 1 1 2 2 2 1 Sec63 Brl domain DnaJ PF00226.26 AMD21155.1 - 6.8e-16 57.7 0.9 1.4e-15 56.7 0.6 1.6 1 0 0 1 1 1 1 DnaJ domain CobT PF06213.7 AMD21155.1 - 0.73 8.9 8.8 1 8.4 6.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TAP_C PF03943.8 AMD21156.1 - 5.3e-14 51.3 0.3 1.7e-13 49.7 0.0 2.1 2 0 0 2 2 2 1 TAP C-terminal domain LRR_4 PF12799.2 AMD21156.1 - 2.6e-06 26.9 5.7 4.9e-05 22.8 2.4 2.7 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 AMD21156.1 - 2.4e-05 23.9 0.3 5e-05 22.9 0.2 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.1 AMD21156.1 - 0.0071 16.3 4.8 1 9.6 0.1 3.4 2 1 0 3 3 3 2 Leucine Rich repeat HATPase_c_5 PF14501.1 AMD21156.1 - 0.042 13.5 0.1 0.26 10.9 0.0 2.3 2 0 0 2 2 2 0 GHKL domain LRR_1 PF00560.28 AMD21156.1 - 3.4 8.0 6.7 10 6.5 0.6 3.7 2 1 1 3 3 3 0 Leucine Rich Repeat KIAA1430 PF13879.1 AMD21157.1 - 0.13 12.6 0.6 0.43 11.0 0.3 1.9 1 1 0 1 1 1 0 KIAA1430 homologue Cyt-b5 PF00173.23 AMD21158.1 - 6.4e-13 48.3 0.0 8.8e-13 47.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFR_dimer PF04253.10 AMD21159.1 - 1.5e-28 98.8 0.0 3.1e-28 97.8 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PIGA PF08288.7 AMD21160.1 - 1e-45 153.9 2.8 4.1e-45 152.0 1.9 2.1 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 AMD21160.1 - 3.7e-28 98.0 0.0 5.9e-28 97.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 AMD21160.1 - 6.2e-17 61.8 0.5 1.1e-16 61.0 0.3 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 AMD21160.1 - 6.6e-14 52.3 0.0 3.2e-13 50.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 AMD21160.1 - 8.8e-13 48.5 0.0 2e-12 47.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 AMD21160.1 - 0.006 16.8 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 AMD21160.1 - 0.011 15.5 1.2 0.026 14.3 0.9 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like Glyco_transf_5 PF08323.6 AMD21160.1 - 0.088 12.2 0.2 0.39 10.1 0.1 2.0 1 1 1 2 2 2 0 Starch synthase catalytic domain Mec-17 PF05301.6 AMD21160.1 - 0.14 12.1 0.1 3.5 7.5 0.0 2.3 2 0 0 2 2 2 0 Touch receptor neuron protein Mec-17 CAP_GLY PF01302.20 AMD21161.1 - 8.3e-20 70.2 1.5 1.5e-19 69.4 1.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain EF-hand_1 PF00036.27 AMD21162.1 - 1.6e-27 92.6 17.2 2.2e-08 32.7 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 AMD21162.1 - 9e-25 86.5 13.6 1e-13 51.1 1.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 AMD21162.1 - 5e-22 75.7 14.5 1e-07 31.1 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 AMD21162.1 - 4.5e-21 74.2 15.5 2.1e-11 43.2 0.5 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 AMD21162.1 - 6.8e-18 63.1 12.0 5.6e-06 25.4 0.1 4.4 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.2 AMD21162.1 - 3.7e-09 36.2 4.6 1.3e-05 24.8 0.2 2.4 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 AMD21162.1 - 1.7e-07 31.0 0.8 0.00015 21.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 AMD21162.1 - 0.0086 16.0 0.9 0.56 10.2 0.0 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region MgtE_N PF03448.12 AMD21162.1 - 0.015 15.6 2.0 0.054 13.8 0.1 2.5 3 0 0 3 3 3 0 MgtE intracellular N domain VCBS PF13517.1 AMD21162.1 - 0.026 14.8 1.8 0.41 11.0 0.0 2.5 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Imm25 PF15571.1 AMD21162.1 - 0.098 12.7 1.5 0.21 11.7 0.2 2.1 2 1 0 2 2 2 0 Immunity protein 25 DUF4469 PF14734.1 AMD21163.1 - 0.069 13.0 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4469) with IG-like fold AAA PF00004.24 AMD21164.1 - 9e-43 145.6 0.0 1.7e-42 144.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 AMD21164.1 - 7.5e-08 32.5 0.2 6.5e-05 22.9 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 AMD21164.1 - 1.1e-06 28.3 0.2 3e-05 23.7 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 AMD21164.1 - 2.8e-05 24.1 0.0 8.2e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 AMD21164.1 - 8e-05 22.7 0.1 0.0037 17.4 0.0 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 AMD21164.1 - 8.7e-05 21.6 0.0 0.00018 20.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 AMD21164.1 - 0.00017 21.2 0.1 0.00034 20.2 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 AMD21164.1 - 0.00061 20.6 1.1 0.0019 19.0 0.1 2.3 2 1 0 2 2 2 1 AAA domain UPF0079 PF02367.12 AMD21164.1 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 AMD21164.1 - 0.0018 18.4 0.0 0.004 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.8 AMD21164.1 - 0.0019 17.0 0.1 0.0034 16.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.16 AMD21164.1 - 0.0042 16.2 0.1 0.0096 15.1 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 AMD21164.1 - 0.0068 16.2 0.2 0.017 14.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.1 AMD21164.1 - 0.0075 16.5 0.1 0.041 14.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 AMD21164.1 - 0.0076 15.6 0.1 0.0076 15.6 0.1 1.6 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_28 PF13521.1 AMD21164.1 - 0.0078 16.1 0.4 0.02 14.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 AMD21164.1 - 0.0087 15.4 3.0 0.015 14.6 0.2 2.4 2 1 1 3 3 3 1 AAA domain AAA_24 PF13479.1 AMD21164.1 - 0.0095 15.5 0.8 0.021 14.4 0.2 1.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 AMD21164.1 - 0.014 15.3 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.6 AMD21164.1 - 0.014 14.0 1.1 0.028 13.1 0.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Zeta_toxin PF06414.7 AMD21164.1 - 0.02 13.9 1.9 0.17 10.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin PhoH PF02562.11 AMD21164.1 - 0.041 13.1 0.3 0.085 12.0 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.12 AMD21164.1 - 0.065 12.0 0.1 0.13 11.1 0.1 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.6 AMD21164.1 - 0.071 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 AMD21164.1 - 0.086 12.4 0.1 0.31 10.6 0.0 1.9 1 1 0 1 1 1 0 NACHT domain AAA_11 PF13086.1 AMD21164.1 - 0.09 12.3 1.6 0.88 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 AMD21164.1 - 0.094 11.8 0.0 0.094 11.8 0.0 2.4 4 0 0 4 4 4 0 KaiC Fib_alpha PF08702.5 AMD21164.1 - 0.14 12.2 1.8 0.34 11.0 1.3 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family AAA_23 PF13476.1 AMD21164.1 - 0.21 11.8 8.4 7.1 6.8 2.6 2.6 2 1 0 2 2 2 0 AAA domain IncA PF04156.9 AMD21164.1 - 0.44 10.1 5.0 0.89 9.1 3.5 1.4 1 0 0 1 1 1 0 IncA protein Anp1 PF03452.9 AMD21165.1 - 1.6e-123 411.1 0.0 2.2e-123 410.7 0.0 1.1 1 0 0 1 1 1 1 Anp1 UBA PF00627.26 AMD21166.1 - 1.8e-21 75.3 2.4 9.9e-13 47.5 0.1 2.6 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.18 AMD21166.1 - 1.9e-13 49.5 0.9 3.7e-13 48.6 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.6 AMD21166.1 - 2.4e-13 49.3 0.1 4.4e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.3 AMD21166.1 - 2.5e-08 33.4 0.9 4.8e-08 32.5 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 AMD21166.1 - 6.6e-06 26.2 0.0 1.9e-05 24.7 0.0 1.8 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain CUE PF02845.11 AMD21166.1 - 7.1e-05 22.2 0.8 4 7.0 0.0 5.2 4 2 1 5 5 5 2 CUE domain Rad60-SLD_2 PF13881.1 AMD21166.1 - 0.0002 21.1 0.1 0.00042 20.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF1421 PF07223.6 AMD21166.1 - 0.02 14.6 0.1 0.2 11.3 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1421) Cytochrome_CBB3 PF13442.1 AMD21167.1 - 6.4e-08 32.6 2.1 1e-06 28.7 1.5 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.16 AMD21167.1 - 1.1e-07 32.5 0.4 2.1e-07 31.6 0.3 1.4 1 1 0 1 1 1 1 Cytochrome c zf-LSD1 PF06943.7 AMD21167.1 - 0.024 14.2 0.2 0.038 13.5 0.1 1.4 1 0 0 1 1 1 0 LSD1 zinc finger NAD_kinase PF01513.16 AMD21168.1 - 7.4e-76 254.6 0.0 9.9e-76 254.2 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 AMD21168.1 - 0.046 13.1 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain GDA1_CD39 PF01150.12 AMD21169.1 - 3.5e-111 371.7 0.0 4.2e-111 371.5 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Isy1 PF06246.7 AMD21170.1 - 3.1e-60 203.7 14.5 1.2e-58 198.5 10.0 2.0 1 1 0 1 1 1 1 Isy1-like splicing family TBPIP PF07106.8 AMD21170.1 - 0.026 14.0 2.9 3.8 7.0 0.7 2.5 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF904 PF06005.7 AMD21170.1 - 5.2 7.4 10.7 0.72 10.1 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF904) fn3 PF00041.16 AMD21171.1 - 0.0011 18.9 0.0 0.0057 16.7 0.0 2.3 1 1 0 1 1 1 1 Fibronectin type III domain CENP-Q PF13094.1 AMD21171.1 - 0.12 12.4 14.9 0.28 11.2 10.3 1.7 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Prefoldin_2 PF01920.15 AMD21171.1 - 0.59 9.9 19.6 0.56 10.0 4.5 3.4 2 1 0 3 3 3 0 Prefoldin subunit DUF2316 PF10078.4 AMD21171.1 - 0.82 9.6 7.6 6.6 6.7 0.1 3.1 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) V_ATPase_I PF01496.14 AMD21171.1 - 1.3 6.7 7.5 2.5 5.8 5.2 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mnd1 PF03962.10 AMD21171.1 - 1.8 8.1 17.1 2.6 7.6 7.5 2.4 1 1 1 2 2 2 0 Mnd1 family DUF1664 PF07889.7 AMD21171.1 - 4.7 7.0 13.2 7 6.4 0.9 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) YL1_C PF08265.6 AMD21172.1 - 4.6e-15 54.8 0.5 5e-14 51.5 0.0 2.4 3 0 0 3 3 3 1 YL1 nuclear protein C-terminal domain Beta_elim_lyase PF01212.16 AMD21173.1 - 2.6e-77 259.8 0.0 3.3e-77 259.4 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Sedlin_N PF04628.8 AMD21174.1 - 5.9e-11 42.3 0.0 7.8e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF676 PF05057.9 AMD21175.1 - 6.3e-42 143.3 0.1 9.9e-42 142.6 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 AMD21175.1 - 1e-06 28.8 0.0 1.6e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 AMD21175.1 - 9.8e-06 25.3 0.0 1.8e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 AMD21175.1 - 0.00012 21.8 0.0 0.00029 20.5 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.6 AMD21175.1 - 0.0042 16.2 0.1 0.7 8.9 0.0 2.6 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_1 PF00561.15 AMD21175.1 - 0.019 14.5 0.1 0.47 9.9 0.0 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 AMD21175.1 - 0.024 14.2 0.0 0.054 13.0 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Lipase_2 PF01674.13 AMD21175.1 - 0.052 12.8 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 2) Zn_clus PF00172.13 AMD21176.1 - 6.2e-07 29.2 12.9 1.1e-06 28.4 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 AMD21176.1 - 6.5 7.0 11.7 21 5.3 7.7 2.0 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region Ctr PF04145.10 AMD21177.1 - 2.1e-25 89.4 14.2 1.3e-13 51.2 5.7 2.0 1 1 1 2 2 2 2 Ctr copper transporter family Enolase_C PF00113.17 AMD21178.1 - 5.4e-153 508.1 0.0 7.3e-153 507.7 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 AMD21178.1 - 6.4e-60 200.8 0.3 1.1e-59 200.1 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE PF01188.16 AMD21178.1 - 0.0014 19.1 0.0 0.0036 17.8 0.0 1.8 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MAAL_C PF07476.6 AMD21178.1 - 0.033 13.1 0.9 0.079 11.8 0.0 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Spc97_Spc98 PF04130.8 AMD21179.1 - 2.1e-86 290.4 5.0 3.5e-86 289.6 3.4 1.3 1 0 0 1 1 1 1 Spc97 / Spc98 family Proteasome PF00227.21 AMD21180.1 - 4.5e-53 179.3 0.1 6.1e-53 178.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 AMD21180.1 - 2.3e-13 49.1 0.1 4e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Bromodomain PF00439.20 AMD21181.1 - 9.3e-25 86.3 1.4 2e-24 85.2 0.9 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 AMD21181.1 - 6e-09 35.9 0.5 1.3e-08 34.8 0.2 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 AMD21181.1 - 3.9e-08 33.1 0.1 7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 AMD21181.1 - 0.0021 18.1 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AMD21181.1 - 0.0056 16.6 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Daxx PF03344.10 AMD21181.1 - 0.021 13.3 20.5 0.03 12.8 14.2 1.2 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 AMD21181.1 - 0.96 7.3 16.0 1.4 6.9 11.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Myc_N PF01056.13 AMD21181.1 - 2 7.5 11.9 2.7 7.0 8.3 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Nop14 PF04147.7 AMD21181.1 - 6.2 4.6 25.2 8.6 4.1 17.5 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.4 AMD21181.1 - 9.7 4.7 29.7 14 4.2 20.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) ThiF PF00899.16 AMD21182.1 - 7.6e-30 103.5 0.0 1.2e-29 102.8 0.0 1.3 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 AMD21182.1 - 0.00081 19.4 0.0 0.0017 18.4 0.0 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 AMD21182.1 - 0.0045 16.1 0.0 0.19 10.8 0.0 2.7 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NMD3 PF04981.8 AMD21183.1 - 1.1e-74 250.5 2.2 1.7e-74 249.8 1.5 1.3 1 0 0 1 1 1 1 NMD3 family zinc_ribbon_6 PF14599.1 AMD21183.1 - 0.27 11.0 0.1 0.27 11.0 0.1 3.3 2 1 1 3 3 3 0 Zinc-ribbon HypA PF01155.14 AMD21183.1 - 0.29 10.8 5.5 7.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family FYVE PF01363.16 AMD21183.1 - 4.2 7.3 6.6 3.4 7.6 2.2 2.3 2 0 0 2 2 2 0 FYVE zinc finger DUF2702 PF10863.3 AMD21184.1 - 1.5e-50 170.6 8.5 2e-50 170.2 5.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2702) RFC1 PF08519.7 AMD21184.1 - 0.16 11.7 2.2 0.098 12.4 0.3 1.5 2 0 0 2 2 2 0 Replication factor RFC1 C terminal domain DEAD PF00270.24 AMD21185.1 - 6.2e-43 146.2 0.1 2.2e-41 141.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21185.1 - 6.3e-28 96.4 0.0 1.3e-27 95.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 AMD21185.1 - 0.00033 19.5 0.0 0.00061 18.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain RRF PF01765.14 AMD21185.1 - 0.0011 18.4 0.1 0.0023 17.4 0.0 1.4 1 0 0 1 1 1 1 Ribosome recycling factor ResIII PF04851.10 AMD21185.1 - 0.0013 18.5 0.0 0.004 17.0 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit GTP1_OBG PF01018.17 AMD21186.1 - 3.4e-33 114.5 2.2 4.3e-24 84.9 1.3 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.18 AMD21186.1 - 5.8e-22 77.8 0.1 1.1e-21 76.9 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD21186.1 - 1.2e-11 44.1 0.1 2.1e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.16 AMD21186.1 - 4.7e-11 42.2 0.1 1.3e-10 40.8 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 AMD21186.1 - 6.7e-06 26.5 0.0 1.6e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 AMD21186.1 - 0.00012 21.5 0.4 0.0049 16.3 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.17 AMD21186.1 - 0.0041 16.5 0.0 0.0084 15.5 0.0 1.6 1 1 0 1 1 1 1 Ras family ArgK PF03308.11 AMD21186.1 - 0.0067 15.2 0.0 0.29 9.8 0.0 2.2 2 0 0 2 2 2 1 ArgK protein SRPRB PF09439.5 AMD21186.1 - 0.035 13.3 0.0 0.093 11.9 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 AMD21186.1 - 0.05 13.4 0.3 7 6.4 0.1 2.4 1 1 1 2 2 2 0 Dynamin family AIG1 PF04548.11 AMD21186.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 AIG1 family THP2 PF09432.5 AMD21187.1 - 1.1e-38 132.0 0.7 1.1e-38 132.0 0.5 1.7 2 0 0 2 2 2 1 Tho complex subunit THP2 APC8 PF04049.8 AMD21188.1 - 1.4e-40 138.3 3.8 2.8e-40 137.3 2.6 1.4 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.23 AMD21188.1 - 6.3e-28 95.2 15.9 3.3e-05 23.2 0.0 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.1 AMD21188.1 - 5.7e-24 83.5 19.1 8.7e-10 38.1 0.3 5.8 5 1 1 6 6 6 4 TPR repeat TPR_8 PF13181.1 AMD21188.1 - 5.2e-21 72.8 15.8 0.00086 18.9 0.0 7.6 5 1 2 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.12 AMD21188.1 - 1.9e-20 71.0 21.2 0.00018 21.1 0.0 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 AMD21188.1 - 1.2e-14 53.4 0.2 0.0083 16.6 0.0 6.3 4 1 3 7 7 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 AMD21188.1 - 1e-12 47.7 21.6 2.7e-05 24.0 0.1 6.3 4 1 3 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 AMD21188.1 - 2e-10 41.0 4.0 3.2e-05 24.4 0.0 6.0 5 1 2 7 7 7 2 Tetratricopeptide repeat Apc3 PF12895.2 AMD21188.1 - 1.4e-09 37.9 23.0 0.0003 20.8 1.7 4.9 3 1 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 AMD21188.1 - 1.8e-08 33.5 2.5 0.065 13.0 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 AMD21188.1 - 2e-07 30.6 11.4 0.0066 16.5 0.1 6.7 8 0 0 8 8 7 2 Tetratricopeptide repeat ChAPs PF09295.5 AMD21188.1 - 1e-06 27.8 0.2 2.9e-06 26.3 0.1 1.8 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.1 AMD21188.1 - 2.5e-06 27.7 2.6 0.006 16.8 0.2 4.6 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 AMD21188.1 - 3.9e-06 26.6 1.6 0.062 13.1 0.5 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 AMD21188.1 - 1.7e-05 24.9 13.0 3.1 8.4 0.0 7.8 8 0 0 8 8 7 1 Tetratricopeptide repeat BTAD PF03704.12 AMD21188.1 - 5.1e-05 23.6 1.4 0.00047 20.4 0.1 2.8 3 0 0 3 3 3 1 Bacterial transcriptional activator domain TPR_15 PF13429.1 AMD21188.1 - 0.00016 20.8 5.1 0.0013 17.8 0.4 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat HTH_Tnp_Mu_2 PF09039.6 AMD21188.1 - 0.011 15.4 0.2 0.03 14.0 0.1 1.7 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain TPR_10 PF13374.1 AMD21188.1 - 0.047 13.6 0.0 2.9 7.9 0.0 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat Sel1 PF08238.7 AMD21188.1 - 0.5 11.0 10.4 44 4.8 0.0 5.3 5 0 0 5 5 5 0 Sel1 repeat PROCN PF08083.6 AMD21189.1 - 3.4e-217 720.7 12.2 6.4e-217 719.8 8.4 1.5 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 AMD21189.1 - 6e-121 402.0 1.0 1e-120 401.2 0.7 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 AMD21189.1 - 3.8e-88 292.8 0.5 7.3e-88 291.9 0.4 1.5 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 AMD21189.1 - 6.1e-77 256.4 2.4 1.4e-76 255.3 1.6 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 AMD21189.1 - 2.2e-65 218.3 0.0 5.3e-65 217.1 0.0 1.7 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.6 AMD21189.1 - 1.1e-46 157.6 0.0 2.4e-46 156.4 0.0 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.4 AMD21189.1 - 9.3e-42 140.8 0.0 2.6e-41 139.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 ALMS_motif PF15309.1 AMD21190.1 - 0.081 12.7 0.2 0.081 12.7 0.1 2.7 3 0 0 3 3 3 0 ALMS motif zf-C3H1 PF10650.4 AMD21190.1 - 0.091 12.2 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative zinc-finger domain CRT10 PF08728.5 AMD21191.1 - 1.1e-165 552.6 4.9 2.5e-165 551.4 3.4 1.5 1 1 0 1 1 1 1 CRT10 MFS_1 PF07690.11 AMD21192.1 - 8.5e-37 126.6 27.5 1.2e-36 126.1 19.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3311 PF11755.3 AMD21192.1 - 0.013 14.9 0.3 0.22 11.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3311) Raptor_N PF14538.1 AMD21193.1 - 6.5e-67 224.1 0.0 1.4e-66 223.1 0.0 1.6 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.27 AMD21193.1 - 3.3e-06 26.7 7.6 0.15 11.9 0.1 6.0 8 0 0 8 8 8 3 WD domain, G-beta repeat BBS2_Mid PF14783.1 AMD21193.1 - 4.5e-05 23.1 1.9 0.00067 19.4 0.0 3.4 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region HEAT PF02985.17 AMD21193.1 - 9.2e-05 22.2 2.4 0.044 13.8 0.0 5.1 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.2 AMD21193.1 - 0.0063 16.3 0.4 0.27 11.0 0.0 2.8 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 AMD21193.1 - 0.035 14.4 0.0 0.57 10.5 0.0 2.9 2 1 1 3 3 3 0 HEAT repeats DUF2435 PF10363.4 AMD21193.1 - 0.06 13.2 0.1 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2435) Elong_Iki1 PF10483.4 AMD21194.1 - 4.6e-82 275.5 4.0 5.2e-82 275.3 2.7 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Gpi16 PF04113.9 AMD21195.1 - 6.6e-190 631.8 0.0 8.4e-190 631.5 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component FUSC PF04632.7 AMD21195.1 - 0.45 8.9 0.1 0.64 8.3 0.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family HEAT_2 PF13646.1 AMD21196.1 - 2.9e-16 59.5 0.0 0.0031 17.7 0.0 7.9 3 2 6 9 9 9 5 HEAT repeats HEAT PF02985.17 AMD21196.1 - 2.7e-15 55.0 8.3 0.015 15.3 0.0 10.3 12 0 0 12 12 12 3 HEAT repeat HEAT_EZ PF13513.1 AMD21196.1 - 7.2e-14 51.7 0.0 1.5 9.3 0.0 8.9 8 2 1 9 9 9 3 HEAT-like repeat Vac14_Fab1_bd PF12755.2 AMD21196.1 - 2.5e-08 34.1 0.0 0.0042 17.4 0.0 4.6 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 AMD21196.1 - 1.7e-06 27.9 0.8 2 8.2 0.0 5.7 6 0 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 AMD21196.1 - 0.0031 16.8 0.5 9.9 5.4 0.0 4.1 3 2 0 3 3 3 2 CLASP N terminal DUF4042 PF13251.1 AMD21196.1 - 0.0059 16.0 0.0 5.4 6.4 0.0 3.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4042) MMS19_C PF12460.3 AMD21196.1 - 0.033 12.9 0.0 13 4.3 0.0 3.8 3 1 0 3 3 3 0 RNAPII transcription regulator C-terminal VHS PF00790.14 AMD21196.1 - 0.046 13.3 0.1 12 5.4 0.0 3.4 3 0 0 3 3 3 0 VHS domain TIP120 PF08623.5 AMD21196.1 - 0.055 13.0 1.4 9.8 5.7 0.0 4.1 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) Adaptin_N PF01602.15 AMD21197.1 - 5.5e-97 325.2 10.4 6.7e-97 324.9 7.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 AMD21197.1 - 6.5e-12 45.5 5.1 0.00014 22.0 0.1 5.5 5 1 1 6 6 6 3 HEAT repeats HEAT PF02985.17 AMD21197.1 - 1.3e-08 34.2 5.9 0.0041 17.0 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 AMD21197.1 - 8.8e-05 22.8 2.6 6.3 7.4 0.1 4.4 3 1 1 4 4 4 2 HEAT-like repeat Cohesin_HEAT PF12765.2 AMD21197.1 - 0.0026 17.6 0.2 2 8.4 0.0 3.1 2 0 0 2 2 2 2 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.2 AMD21197.1 - 0.0069 16.2 6.9 0.13 12.1 0.1 4.6 3 2 3 6 6 6 1 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.1 AMD21197.1 - 0.015 15.2 0.9 8.3 6.3 0.0 4.0 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Sigma70_ner PF04546.8 AMD21197.1 - 7.4 6.1 13.2 14 5.2 9.1 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Ssl1 PF04056.9 AMD21198.1 - 6.1e-87 290.2 0.0 9.1e-87 289.6 0.0 1.3 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 AMD21198.1 - 1.3e-21 76.3 12.9 1.3e-21 76.3 9.0 2.7 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.1 AMD21198.1 - 1.8e-13 50.9 0.0 2.7e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 AMD21198.1 - 4.4e-06 26.5 0.0 9e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Taeniidae_ag PF05596.6 AMD21198.1 - 0.07 12.9 0.1 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 Taeniidae antigen Sporozoite_P67 PF05642.6 AMD21198.1 - 2.7 5.7 4.7 4 5.1 3.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Glyco_hydro_92 PF07971.7 AMD21199.1 - 7.7e-123 410.7 4.2 1.2e-122 410.1 2.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 CMS1 PF14617.1 AMD21200.1 - 7.7e-10 38.2 19.4 4.4e-05 22.6 7.6 3.0 1 1 2 3 3 3 2 U3-containing 90S pre-ribosomal complex subunit DUF162 PF02589.10 AMD21200.1 - 0.093 12.2 0.0 14 5.0 0.0 2.5 1 1 0 2 2 2 0 Uncharacterised ACR, YkgG family COG1556 Adaptin_N PF01602.15 AMD21201.1 - 9.1e-56 189.2 15.1 1.1e-55 188.9 10.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 AMD21201.1 - 7.4e-06 26.1 0.9 0.18 12.0 0.3 3.9 2 1 1 3 3 3 2 HEAT repeats S_100 PF01023.14 AMD21201.1 - 0.01 15.1 0.0 0.035 13.4 0.0 2.0 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Response_reg PF00072.19 AMD21202.1 - 1.9e-19 69.7 0.0 3.4e-12 46.3 0.0 2.4 2 0 0 2 2 2 2 Response regulator receiver domain AMIN PF11741.3 AMD21202.1 - 0.03 14.2 0.7 0.1 12.5 0.1 2.2 2 0 0 2 2 2 0 AMIN domain SMC_Nse1 PF07574.8 AMD21203.1 - 7.4e-51 172.6 0.5 8.9e-51 172.3 0.3 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 AMD21203.1 - 3.8e-11 42.8 8.5 7.3e-11 41.8 5.9 1.5 1 0 0 1 1 1 1 RING-like domain LOH1CR12 PF10158.4 AMD21203.1 - 0.047 13.4 0.7 0.77 9.5 0.0 2.6 3 0 0 3 3 3 0 Tumour suppressor protein zf-RING_2 PF13639.1 AMD21203.1 - 0.7 9.7 6.6 1.6 8.6 3.3 2.4 2 1 0 2 2 2 0 Ring finger domain DnaJ PF00226.26 AMD21204.1 - 2.9e-05 23.7 0.1 5.2e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 AMD21204.1 - 0.00047 19.9 0.0 0.00061 19.5 0.0 1.2 1 0 0 1 1 1 1 Pam16 Ribosomal_L24e PF01246.15 AMD21205.1 - 1.3e-30 105.0 1.8 3.3e-30 103.7 1.3 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FCS PF06467.9 AMD21205.1 - 0.3 10.7 3.2 0.63 9.7 2.2 1.5 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Ribosomal_L28e PF01778.12 AMD21207.1 - 1.7e-33 115.4 2.5 1.7e-33 115.4 1.7 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.9 AMD21207.1 - 7.4e-29 99.8 16.7 7.4e-29 99.8 11.6 2.7 1 1 1 2 2 2 1 Mak16 protein C-terminal region CDC45 PF02724.9 AMD21207.1 - 1.5 6.7 23.3 2.4 6.0 16.2 1.2 1 0 0 1 1 1 0 CDC45-like protein E1-E2_ATPase PF00122.15 AMD21208.1 - 7.6e-18 64.3 1.5 1.4e-17 63.5 1.1 1.4 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 AMD21208.1 - 2.6e-17 63.6 0.1 7.7e-17 62.0 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AMD21208.1 - 2.1e-13 51.1 4.1 5.6e-10 39.9 3.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 AMD21208.1 - 9e-10 38.3 0.0 2.2e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 AMD21208.1 - 0.00025 20.7 1.2 0.0071 15.9 0.9 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 AMD21208.1 - 0.0074 16.5 0.1 0.026 14.7 0.1 1.9 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Aldedh PF00171.17 AMD21209.1 - 1e-10 40.5 0.2 4.9e-08 31.7 0.0 2.2 2 0 0 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.12 AMD21209.1 - 0.0083 15.0 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) PyrI PF01948.13 AMD21209.1 - 0.22 11.5 0.2 0.22 11.5 0.1 1.9 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain Saw1 PF11561.3 AMD21210.1 - 4.1e-42 144.0 5.9 8.9e-42 142.9 4.1 1.5 1 1 0 1 1 1 1 Single strand annealing-weakened 1 Hph PF13694.1 AMD21211.1 - 8.2e-06 25.9 0.4 2e-05 24.6 0.1 1.8 2 0 0 2 2 2 1 Sec63/Sec62 complex-interacting family COG5 PF10392.4 AMD21211.1 - 0.0054 16.6 1.7 0.011 15.7 1.2 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 NPV_P10 PF05531.7 AMD21211.1 - 0.075 13.2 1.8 1.7 8.9 0.1 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FliJ PF02050.11 AMD21211.1 - 1.3 9.0 7.7 6 6.9 5.4 2.0 1 1 0 1 1 1 0 Flagellar FliJ protein Myosin_head PF00063.16 AMD21212.1 - 7.9e-261 866.9 8.1 7.9e-261 866.9 5.6 1.7 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.14 AMD21212.1 - 9.6e-35 118.6 1.8 6.6e-34 115.9 1.3 2.6 1 0 0 1 1 1 1 DIL domain IQ PF00612.22 AMD21212.1 - 0.00044 19.6 14.4 2.2 8.1 0.0 6.1 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_22 PF13401.1 AMD21212.1 - 0.0023 18.0 0.0 0.0023 18.0 0.0 3.9 3 1 0 3 3 3 1 AAA domain Myosin_N PF02736.14 AMD21212.1 - 0.0031 17.1 0.0 0.0086 15.7 0.0 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Saccharop_dh_N PF04455.7 AMD21212.1 - 0.0089 16.1 0.4 0.19 11.8 0.0 2.7 2 0 0 2 2 2 1 LOR/SDH bifunctional enzyme conserved region AAA_16 PF13191.1 AMD21212.1 - 0.025 14.5 2.7 0.1 12.5 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain DUF972 PF06156.8 AMD21212.1 - 0.11 12.8 16.8 0.076 13.3 0.3 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF972) AAA_19 PF13245.1 AMD21212.1 - 0.14 11.9 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain FlaC_arch PF05377.6 AMD21212.1 - 0.36 10.7 15.2 0.38 10.6 1.0 4.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 AMD21212.1 - 1 8.4 11.3 0.27 10.3 1.9 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF948 PF06103.6 AMD21212.1 - 4.4 7.2 9.9 0.92 9.4 1.3 3.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.6 AMD21212.1 - 6.9 6.4 32.4 0.43 10.3 9.1 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DivIC PF04977.10 AMD21212.1 - 8.4 5.9 29.8 1.4 8.4 0.7 5.6 4 1 1 5 5 5 0 Septum formation initiator Synaptobrevin PF00957.16 AMD21213.1 - 4.3e-32 109.5 1.9 5e-32 109.3 1.3 1.0 1 0 0 1 1 1 1 Synaptobrevin TMEM117 PF15113.1 AMD21213.1 - 0.029 12.9 0.2 0.035 12.7 0.1 1.0 1 0 0 1 1 1 0 TMEM117 protein family Chloroplast_duf PF14476.1 AMD21213.1 - 0.099 11.4 0.0 0.12 11.1 0.0 1.0 1 0 0 1 1 1 0 Petal formation-expressed DUF912 PF06024.7 AMD21213.1 - 0.099 12.6 1.0 0.13 12.2 0.6 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ODV-E18 PF10717.4 AMD21213.1 - 0.2 11.1 0.7 0.35 10.3 0.5 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 OppC_N PF12911.2 AMD21213.1 - 1.9 7.9 6.4 3.8 6.9 4.4 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF2040 PF09745.4 AMD21215.1 - 1.1e-09 38.1 8.4 1.1e-09 38.1 5.8 2.2 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) bZIP_2 PF07716.10 AMD21215.1 - 1.4 8.7 7.4 4.1 7.3 0.4 3.0 2 0 0 2 2 2 0 Basic region leucine zipper DNA_pol_A PF00476.15 AMD21216.1 - 4.5e-104 348.1 0.0 1.1e-103 346.8 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 AMD21216.1 - 0.041 13.3 0.6 0.19 11.1 0.4 2.0 1 1 0 1 1 1 0 3'-5' exonuclease vATP-synt_E PF01991.13 AMD21217.1 - 4.2e-56 189.3 17.7 4.9e-56 189.1 12.3 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Vps35 PF03635.12 AMD21217.1 - 0.0036 15.5 7.7 0.0044 15.2 5.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 BAR_3_WASP_bdg PF10456.4 AMD21217.1 - 0.0057 15.9 2.3 0.0068 15.7 1.6 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein CorA PF01544.13 AMD21218.1 - 2.8e-09 36.4 3.2 4.6e-09 35.7 2.2 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SKIP_SNW PF02731.10 AMD21220.1 - 8.6e-52 174.7 4.5 8.6e-52 174.7 3.1 2.6 3 0 0 3 3 3 1 SKIP/SNW domain DltD_M PF04918.7 AMD21220.1 - 1.1 9.4 14.3 3.6 7.7 7.2 2.3 2 0 0 2 2 2 0 DltD central region RNase_P_Rpp14 PF01900.14 AMD21221.1 - 4.3e-32 110.1 0.1 5.4e-32 109.8 0.1 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family Syntaxin-18_N PF10496.4 AMD21222.1 - 2.5e-20 72.0 0.9 1.1e-19 70.0 0.7 2.1 1 0 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.14 AMD21222.1 - 2.9e-05 23.6 4.6 2.9e-05 23.6 3.2 2.4 3 0 0 3 3 3 1 SNARE domain SecE PF00584.15 AMD21222.1 - 1 8.9 2.9 1.2 8.7 0.6 2.1 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex Y2_Tnp PF04986.8 AMD21222.1 - 1.1 8.9 8.0 0.12 12.1 0.5 2.4 2 1 1 3 3 3 0 Putative transposase Thymidylat_synt PF00303.14 AMD21223.1 - 8.5e-120 398.7 0.0 9.5e-120 398.6 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase DIT1_PvcA PF05141.7 AMD21223.1 - 0.088 12.1 0.1 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Shugoshin_N PF07558.6 AMD21224.1 - 9.1e-15 54.0 6.6 9.1e-15 54.0 4.6 2.3 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.6 AMD21224.1 - 2.3e-11 42.9 3.6 2.3e-11 42.9 2.5 2.0 2 0 0 2 2 2 1 Shugoshin C terminus DASH_Dad2 PF08654.5 AMD21225.1 - 3.3e-35 120.1 1.5 3.9e-35 119.9 1.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad2 DHC_N2 PF08393.8 AMD21225.1 - 0.00087 17.9 3.7 0.001 17.6 2.6 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 DASH_Duo1 PF08651.5 AMD21225.1 - 0.01 15.4 2.2 0.015 14.8 1.5 1.3 1 0 0 1 1 1 0 DASH complex subunit Duo1 Ran-binding PF05508.6 AMD21225.1 - 0.034 13.0 1.7 0.04 12.7 1.2 1.1 1 0 0 1 1 1 0 RanGTP-binding protein Med9 PF07544.8 AMD21225.1 - 0.056 13.1 2.2 0.077 12.7 1.6 1.2 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 HTH_Tnp_IS630 PF01710.11 AMD21225.1 - 0.09 12.4 0.2 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 Transposase Reo_sigmaC PF04582.7 AMD21225.1 - 0.13 11.3 0.4 0.14 11.3 0.3 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF2762 PF10960.3 AMD21225.1 - 0.21 11.3 1.3 16 5.2 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2762) G-gamma PF00631.17 AMD21225.1 - 0.27 10.9 2.1 7.1 6.4 1.4 2.4 1 1 0 1 1 1 0 GGL domain DUF3744 PF12558.3 AMD21225.1 - 0.36 11.2 2.9 13 6.2 0.7 2.4 1 1 1 2 2 2 0 ATP-binding cassette cobalt transporter Nucleoporin_C PF03177.9 AMD21226.1 - 5.9e-63 213.3 19.6 9.3e-63 212.6 13.6 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 AMD21226.1 - 4.9e-56 190.2 5.1 7.2e-56 189.7 3.5 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Brix PF04427.13 AMD21227.1 - 5.6e-37 127.2 1.0 7.3e-37 126.8 0.7 1.1 1 0 0 1 1 1 1 Brix domain THF_DHG_CYH PF00763.18 AMD21228.1 - 2.1e-19 69.6 0.1 2.1e-18 66.4 0.0 2.1 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 AMD21228.1 - 5e-18 64.7 0.0 3.9e-11 42.2 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain RTP PF02334.11 AMD21228.1 - 0.065 13.1 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Replication terminator protein FTP PF07504.8 AMD21228.1 - 0.13 11.7 1.0 0.26 10.7 0.3 1.8 2 0 0 2 2 2 0 Fungalysin/Thermolysin Propeptide Motif RabGAP-TBC PF00566.13 AMD21229.1 - 8e-51 172.5 1.8 8e-51 172.5 1.2 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Lactamase_B_2 PF12706.2 AMD21230.1 - 1.9e-30 105.8 0.3 3.2e-30 105.1 0.2 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 AMD21230.1 - 4.6e-22 77.2 0.0 9.6e-22 76.2 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.22 AMD21230.1 - 0.043 13.4 0.1 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Vps5 PF09325.5 AMD21231.1 - 2.9e-78 262.3 9.2 4.7e-78 261.6 6.4 1.4 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 AMD21231.1 - 2.1e-23 82.2 0.2 9.7e-23 80.1 0.0 2.2 2 0 0 2 2 2 1 PX domain BAR_3_WASP_bdg PF10456.4 AMD21231.1 - 0.011 15.0 2.2 0.024 13.9 1.3 1.8 2 1 0 2 2 2 0 WASP-binding domain of Sorting nexin protein Fib_alpha PF08702.5 AMD21231.1 - 8.3 6.5 11.0 1.6 8.8 2.9 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Alg6_Alg8 PF03155.10 AMD21232.1 - 5e-151 503.7 40.5 5.8e-151 503.4 28.1 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Cytochrom_C1 PF02167.10 AMD21234.1 - 2.9e-82 275.5 0.0 3.5e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.1 AMD21234.1 - 0.00036 20.6 0.0 0.0007 19.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.16 AMD21234.1 - 0.0019 18.9 0.0 0.0051 17.6 0.0 1.8 1 0 0 1 1 1 1 Cytochrome c Actin PF00022.14 AMD21235.1 - 5.5e-54 183.0 0.0 2.3e-38 131.6 0.0 2.0 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.8 AMD21235.1 - 2.2e-06 26.5 0.0 0.0054 15.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein NuA4 PF09340.5 AMD21236.1 - 8.6e-23 79.7 0.2 1.1e-22 79.4 0.2 1.1 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 DUF668 PF05003.7 AMD21236.1 - 0.048 13.8 0.2 0.068 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF668) Malate_synthase PF01274.17 AMD21236.1 - 0.091 10.7 0.1 0.079 10.9 0.1 1.0 1 0 0 1 1 1 0 Malate synthase DUF2811 PF10929.3 AMD21236.1 - 0.18 11.8 2.9 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2811) Transposase_1 PF01359.13 AMD21236.1 - 0.23 11.2 2.3 0.39 10.5 1.4 1.5 1 1 0 1 1 1 0 Transposase (partial DDE domain) AIM24 PF01987.12 AMD21237.1 - 0.0011 18.4 0.0 0.033 13.6 0.0 2.6 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 tRNA-synt_His PF13393.1 AMD21238.1 - 1e-39 136.4 0.0 1.2e-38 132.9 0.0 2.1 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 AMD21238.1 - 5.3e-19 68.4 0.0 2.2e-18 66.4 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AMD21238.1 - 1.1e-12 47.7 0.0 2.1e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 AMD21238.1 - 0.0057 15.4 0.0 0.46 9.2 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 AMD21238.1 - 0.065 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) IDO PF01231.13 AMD21239.1 - 8.4e-158 525.2 0.0 9.9e-158 525.0 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Clathrin_propel PF01394.15 AMD21239.1 - 0.1 12.9 0.0 0.31 11.4 0.0 1.8 1 0 0 1 1 1 0 Clathrin propeller repeat Cid2 PF09774.4 AMD21240.1 - 5.8e-25 88.1 2.4 7.7e-25 87.7 1.6 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Ribos_L4_asso_C PF14374.1 AMD21240.1 - 0.023 14.5 0.2 0.023 14.5 0.1 2.1 3 0 0 3 3 3 0 60S ribosomal protein L4 C-terminal domain HHH_2 PF12826.2 AMD21240.1 - 0.046 13.6 0.0 1.2 9.0 0.0 2.3 1 1 0 1 1 1 0 Helix-hairpin-helix motif DUF2524 PF10732.4 AMD21240.1 - 0.051 13.7 0.4 0.24 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) Lgl_C PF08596.5 AMD21241.1 - 3.7e-111 371.3 0.5 8.3e-111 370.2 0.2 1.7 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal Apc4_WD40 PF12894.2 AMD21241.1 - 3.3e-05 23.2 0.0 0.0042 16.5 0.0 2.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 AMD21241.1 - 0.015 15.1 4.3 13 5.8 0.0 5.4 6 0 0 6 6 6 0 WD domain, G-beta repeat IR1-M PF12185.3 AMD21241.1 - 0.17 11.6 0.3 0.33 10.6 0.2 1.4 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain Pkinase PF00069.20 AMD21242.1 - 1e-63 214.9 0.0 2.6e-63 213.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21242.1 - 2.6e-35 121.7 0.0 5.2e-35 120.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 AMD21242.1 - 2.1e-28 97.8 13.4 2.9e-16 58.9 3.6 2.4 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.17 AMD21242.1 - 4.3e-19 67.9 35.3 5.5e-10 38.8 9.8 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 AMD21242.1 - 3.3e-11 43.5 0.4 1e-10 41.9 0.3 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 AMD21242.1 - 0.01 14.8 0.0 0.02 13.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like PHD_2 PF13831.1 AMD21242.1 - 1.2 8.5 16.4 0.81 9.0 2.7 2.7 2 0 0 2 2 2 0 PHD-finger zf-RING_2 PF13639.1 AMD21243.1 - 1.1 9.1 10.1 0.94 9.3 2.1 3.4 3 0 0 3 3 3 0 Ring finger domain zf-HC5HC2H_2 PF13832.1 AMD21244.1 - 1.3e-32 112.0 6.3 1.3e-32 112.0 4.3 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 AMD21244.1 - 1.5e-28 98.7 4.5 1.5e-28 98.7 3.1 3.5 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.1 AMD21244.1 - 2.1e-14 52.5 3.0 2.1e-14 52.5 2.1 2.7 2 0 0 2 2 2 1 PHD-finger EPL1 PF10513.4 AMD21244.1 - 2.3e-14 53.9 1.5 2.3e-14 53.9 1.0 1.8 2 0 0 2 2 2 1 Enhancer of polycomb-like PHD PF00628.24 AMD21244.1 - 2.3e-11 43.2 19.4 6.1e-10 38.6 3.2 2.6 2 0 0 2 2 2 2 PHD-finger zf-RING-like PF08746.6 AMD21244.1 - 0.0057 16.6 16.3 0.082 12.9 4.9 2.6 2 0 0 2 2 2 2 RING-like domain DNA_topoisoIV PF00521.15 AMD21244.1 - 0.011 14.6 0.6 0.011 14.6 0.4 1.8 2 0 0 2 2 2 0 DNA gyrase/topoisomerase IV, subunit A Bromodomain PF00439.20 AMD21244.1 - 0.012 15.5 0.1 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 Bromodomain C1_1 PF00130.17 AMD21244.1 - 0.041 13.6 0.2 0.041 13.6 0.1 2.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 AMD21244.1 - 0.067 12.9 17.3 0.12 12.1 2.8 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 WD40 PF00400.27 AMD21245.1 - 9.2e-14 50.7 0.8 2.8e-05 23.8 0.0 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat DDE_Tnp_1 PF01609.16 AMD21245.1 - 0.038 13.5 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE domain Pkinase PF00069.20 AMD21247.1 - 5.3e-63 212.5 0.0 8e-63 212.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21247.1 - 5.3e-40 137.1 0.0 8e-40 136.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21247.1 - 0.00041 19.4 0.0 0.00077 18.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 AMD21247.1 - 0.011 14.5 0.0 0.021 13.6 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 DEAD PF00270.24 AMD21248.1 - 1.7e-41 141.5 0.0 3.4e-41 140.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21248.1 - 4.7e-25 87.2 0.0 9.8e-25 86.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD21248.1 - 0.0074 16.1 1.2 0.062 13.1 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit PNP_UDP_1 PF01048.15 AMD21249.1 - 2.5e-37 128.1 0.0 2.9e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily WD40 PF00400.27 AMD21250.1 - 5.1e-43 143.4 19.5 6.8e-10 38.4 0.3 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 AMD21250.1 - 0.0026 17.4 3.5 0.25 11.0 0.1 3.3 2 1 2 4 4 4 2 Transcription factor IIIC subunit delta N-term VCBS PF13517.1 AMD21250.1 - 0.0093 16.3 0.2 11 6.4 0.0 4.0 4 0 0 4 4 4 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Kelch_6 PF13964.1 AMD21250.1 - 0.019 15.1 0.5 3.5 7.9 0.0 3.2 3 0 0 3 3 3 0 Kelch motif YmzC PF14157.1 AMD21250.1 - 0.069 12.9 0.1 4.6 7.1 0.0 3.2 3 0 0 3 3 3 0 YmzC-like protein BCS1_N PF08740.6 AMD21252.1 - 2.7e-50 170.5 0.4 5.1e-50 169.6 0.3 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 AMD21252.1 - 1.3e-22 80.4 0.0 8.2e-22 77.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 AMD21252.1 - 4.1e-06 27.6 0.0 8.9e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD21252.1 - 0.00041 20.4 0.0 0.0029 17.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.1 AMD21252.1 - 0.00052 20.0 0.0 0.00077 19.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AMD21252.1 - 0.00078 19.3 0.0 0.0017 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 AMD21252.1 - 0.0012 17.8 0.0 0.0042 16.1 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 AMD21252.1 - 0.0016 18.7 0.0 0.0052 17.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 AMD21252.1 - 0.0023 17.5 0.1 0.045 13.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 AMD21252.1 - 0.0024 17.7 0.0 0.0044 16.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 AMD21252.1 - 0.003 17.3 0.0 0.0082 15.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 AMD21252.1 - 0.0069 16.3 0.0 0.02 14.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 AMD21252.1 - 0.007 15.7 0.0 0.017 14.5 0.0 1.6 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.8 AMD21252.1 - 0.009 14.9 0.0 0.017 14.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 AMD21252.1 - 0.013 14.6 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.1 AMD21252.1 - 0.014 14.9 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.12 AMD21252.1 - 0.021 14.3 0.2 1.4 8.4 0.0 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.17 AMD21252.1 - 0.035 14.2 0.0 0.081 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 AMD21252.1 - 0.037 14.3 0.0 0.068 13.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 AMD21252.1 - 0.038 13.6 0.0 0.078 12.6 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase KaiC PF06745.8 AMD21252.1 - 0.048 12.7 0.0 0.085 11.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.1 AMD21252.1 - 0.055 13.2 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_28 PF13521.1 AMD21252.1 - 0.064 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 AMD21252.1 - 0.086 13.3 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein NACHT PF05729.7 AMD21252.1 - 0.11 12.1 0.0 0.27 10.8 0.0 1.7 1 0 0 1 1 1 0 NACHT domain GATase_3 PF07685.9 AMD21252.1 - 0.11 12.0 0.1 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain AAA_11 PF13086.1 AMD21252.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 AMD21252.1 - 0.12 11.1 0.0 0.35 9.5 0.0 1.7 2 0 0 2 2 2 0 TIP49 C-terminus AAA_23 PF13476.1 AMD21252.1 - 0.12 12.7 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Polyoma_lg_T_C PF06431.6 AMD21252.1 - 0.16 10.5 0.0 0.22 10.1 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus Lipase_GDSL PF00657.17 AMD21253.1 - 3.5e-24 85.9 0.0 4.1e-24 85.7 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 AMD21253.1 - 1.4e-19 70.9 0.0 1.7e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_3 PF14606.1 AMD21253.1 - 0.022 14.4 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Pyr_redox_3 PF13738.1 AMD21254.1 - 0.0011 19.0 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 AMD21254.1 - 0.0061 16.3 0.0 0.03 14.0 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 AMD21254.1 - 0.0095 15.9 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 AMD21254.1 - 0.026 14.3 0.0 0.34 10.7 0.0 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F1F0-ATPsyn_F PF10791.4 AMD21255.1 - 3e-39 133.1 0.3 3.4e-39 132.9 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.4 AMD21255.1 - 0.0065 16.5 0.0 0.0075 16.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f LSM PF01423.17 AMD21256.1 - 6e-17 60.9 0.0 7.1e-17 60.7 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 AMD21256.1 - 1.1e-05 25.3 0.0 1.3e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.2 AMD21256.1 - 0.015 15.0 0.0 0.019 14.7 0.0 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain RhoGAP PF00620.22 AMD21257.1 - 4e-41 140.1 3.6 5e-41 139.8 0.9 2.2 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.17 AMD21257.1 - 6.5e-12 45.3 28.2 8.1e-06 25.8 5.8 2.5 2 0 0 2 2 2 2 LIM domain DFF-C PF09033.5 AMD21257.1 - 0.13 12.0 4.8 0.067 13.0 1.4 1.9 2 0 0 2 2 2 0 DNA Fragmentation factor 45kDa, C terminal domain Complex1_LYR PF05347.10 AMD21258.1 - 8e-12 44.7 1.4 9.5e-12 44.5 1.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 AMD21258.1 - 5.2e-10 39.3 1.9 6.1e-10 39.1 1.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Nuc-transf PF10127.4 AMD21258.1 - 0.08 12.2 0.4 0.082 12.2 0.3 1.1 1 0 0 1 1 1 0 Predicted nucleotidyltransferase Glyco_transf_21 PF13506.1 AMD21259.1 - 7.2e-18 64.4 0.0 4.9e-14 51.9 0.0 2.5 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.1 AMD21259.1 - 1.3e-11 44.7 0.0 3.6e-11 43.2 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 AMD21259.1 - 2.5e-05 24.0 0.0 4.4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 AIRC PF00731.15 AMD21260.1 - 1.1e-63 213.0 7.3 3.2e-63 211.5 2.5 2.3 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.17 AMD21260.1 - 1e-61 207.2 0.0 1.6e-61 206.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 AMD21260.1 - 1e-05 25.3 0.0 2.2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain 2-Hacid_dh_C PF02826.14 AMD21260.1 - 0.0024 17.0 0.0 0.0051 15.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Dala_Dala_lig_C PF07478.8 AMD21260.1 - 0.0052 16.1 0.0 0.056 12.8 0.0 2.5 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus TrkA_N PF02254.13 AMD21260.1 - 0.0086 16.0 0.1 0.057 13.4 0.0 2.2 2 0 0 2 2 2 1 TrkA-N domain FleQ PF06490.6 AMD21260.1 - 0.021 14.9 0.1 0.26 11.4 0.0 2.7 3 0 0 3 3 3 0 Flagellar regulatory protein FleQ PHP PF02811.14 AMD21260.1 - 0.032 14.0 0.0 0.095 12.4 0.0 1.7 2 0 0 2 2 2 0 PHP domain Afi1 PF07792.7 AMD21261.1 - 3.7e-41 140.5 0.0 7.7e-41 139.4 0.0 1.6 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.5 AMD21261.1 - 4.4e-27 94.0 0.2 1e-26 92.8 0.1 1.7 1 0 0 1 1 1 1 Stabilization of polarity axis RRM_1 PF00076.17 AMD21262.1 - 4.3e-12 45.4 0.0 8.3e-12 44.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21262.1 - 1.1e-10 41.3 0.0 1.8e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21262.1 - 0.00031 20.5 0.0 0.00057 19.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 AMD21262.1 - 2.3 8.7 14.6 0.064 13.6 3.3 2.9 2 1 1 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 Mito_carr PF00153.22 AMD21264.1 - 7.7e-60 198.6 0.7 3.7e-20 71.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_60s PF00428.14 AMD21265.1 - 5.2e-25 87.6 10.0 6.2e-25 87.4 6.9 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Peptidase_M22 PF00814.20 AMD21266.1 - 7.2e-84 281.4 0.0 8.6e-84 281.1 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family CmcH_NodU PF02543.10 AMD21266.1 - 0.015 14.4 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase Acetyltransf_CG PF14542.1 AMD21266.1 - 0.063 13.1 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DASH_Spc34 PF08657.5 AMD21267.1 - 7.7e-69 232.2 3.6 8.7e-69 232.0 2.5 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 HALZ PF02183.13 AMD21267.1 - 0.0012 18.5 0.2 0.0012 18.5 0.2 2.4 2 0 0 2 2 2 1 Homeobox associated leucine zipper AAA_23 PF13476.1 AMD21267.1 - 0.071 13.4 4.6 0.1 12.9 3.1 1.3 1 1 0 1 1 1 0 AAA domain WD40 PF00400.27 AMD21268.1 - 1.4e-37 126.2 7.5 2e-09 36.9 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.3 AMD21268.1 - 2.5e-08 32.5 9.6 0.0016 16.7 0.0 5.2 3 2 2 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 AMD21268.1 - 7.1e-07 28.9 0.2 4.1e-05 23.3 0.0 3.3 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Mdv1 PF11542.3 AMD21268.1 - 0.00073 19.4 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial division protein 1 DUF3249 PF11615.3 AMD21268.1 - 0.012 15.3 0.1 2.7 7.8 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3249) Nefa_Nip30_N PF10187.4 AMD21269.1 - 0.0023 18.0 13.7 0.0023 18.0 9.5 1.8 1 1 1 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF1593 PF07632.6 AMD21269.1 - 0.3 10.3 4.1 0.34 10.1 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) She9_MDM33 PF05546.6 AMD21269.1 - 1.1 8.7 11.8 1.3 8.4 8.1 1.1 1 0 0 1 1 1 0 She9 / Mdm33 family Fcf1 PF04900.7 AMD21270.1 - 1.3e-37 127.8 0.2 6.2e-37 125.7 0.1 1.9 2 0 0 2 2 2 1 Fcf1 PP2C PF00481.16 AMD21271.1 - 1.7e-68 230.8 0.3 2.6e-68 230.1 0.2 1.3 1 1 0 1 1 1 1 Protein phosphatase 2C Nitrate_red_del PF02613.10 AMD21271.1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Nitrate reductase delta subunit Med2 PF11214.3 AMD21272.1 - 1.5e-30 105.3 5.7 2.8e-30 104.4 4.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit 2 ATP-synt_DE_N PF02823.11 AMD21273.1 - 7.9e-17 60.7 0.0 1.1e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Rad21_Rec8_N PF04825.8 AMD21274.1 - 2.4e-24 85.4 0.1 5e-24 84.4 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 AMD21274.1 - 8e-10 37.7 0.1 1.7e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 AMD21274.1 - 6.6e-05 22.6 0.1 0.00012 21.7 0.1 1.4 1 0 0 1 1 1 1 ScpA/B protein DRIM PF07539.7 AMD21275.1 - 1.3e-45 154.2 1.3 2e-44 150.4 0.0 3.9 3 0 0 3 3 3 1 Down-regulated in metastasis RIX1 PF08167.7 AMD21275.1 - 0.0097 15.5 0.0 0.0097 15.5 0.0 6.7 7 2 2 9 9 9 1 rRNA processing/ribosome biogenesis HEAT PF02985.17 AMD21275.1 - 0.011 15.7 6.5 6.2 7.1 0.0 7.5 8 0 0 8 8 8 0 HEAT repeat HMG_box PF00505.14 AMD21276.1 - 3.7e-16 59.1 2.2 6.4e-16 58.3 1.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 AMD21276.1 - 1.1e-13 51.3 1.1 1.8e-13 50.6 0.8 1.4 1 0 0 1 1 1 1 HMG-box domain DUF155 PF02582.9 AMD21277.1 - 2.2e-60 203.5 1.9 3.2e-60 203.0 1.0 1.5 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.1 AMD21277.1 - 0.02 15.1 0.0 0.053 13.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Histone PF00125.19 AMD21278.1 - 5.1e-26 90.5 0.0 6.8e-26 90.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 AMD21278.1 - 3.7e-06 26.8 0.0 6.5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 AMD21279.1 - 1.6e-21 76.2 0.2 2.2e-21 75.7 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 AMD21279.1 - 1.7e-06 28.0 0.1 3.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 AMD21279.1 - 0.0013 18.9 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 AMD21279.1 - 0.016 13.9 2.2 0.019 13.6 1.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein RNA_pol_Rpb2_1 PF04563.10 AMD21279.1 - 0.92 8.3 3.9 6.1 5.7 0.7 2.0 1 1 1 2 2 2 0 RNA polymerase beta subunit Trehalase PF01204.13 AMD21280.1 - 5.3e-181 602.7 0.1 6.2e-181 602.4 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 AMD21280.1 - 1.2e-16 59.6 0.6 2.2e-16 58.8 0.4 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Ran_BP1 PF00638.13 AMD21281.1 - 3.2e-54 182.1 3.0 4.5e-54 181.6 2.1 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 AMD21281.1 - 1.4e-05 24.8 1.3 0.00018 21.2 0.9 2.1 1 1 0 1 1 1 1 WH1 domain Prenyltransf PF01255.14 AMD21282.1 - 1.4e-73 246.7 0.0 1.7e-73 246.4 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase DUF4146 PF13652.1 AMD21282.1 - 0.045 13.5 0.0 0.097 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4146) polyprenyl_synt PF00348.12 AMD21283.1 - 1.3e-54 184.8 0.1 1.7e-48 164.7 0.1 3.1 2 1 0 2 2 2 2 Polyprenyl synthetase Mannosyl_trans2 PF04188.8 AMD21284.1 - 2.6e-66 224.3 43.6 4.3e-64 217.0 30.2 2.2 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V)) RCR PF12273.3 AMD21285.1 - 5.1e-30 104.6 5.5 2.9e-29 102.2 3.8 1.8 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Git3 PF11710.3 AMD21285.1 - 0.041 13.4 0.0 0.056 12.9 0.0 1.2 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 DAG1 PF05454.6 AMD21285.1 - 0.13 11.4 0.1 0.13 11.4 0.1 1.8 1 1 1 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) HA2 PF04408.18 AMD21286.1 - 7.2e-27 93.3 0.0 1.7e-26 92.1 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 AMD21286.1 - 1.2e-24 86.3 0.0 2.8e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 AMD21286.1 - 2.9e-12 46.2 0.0 6.6e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AMD21286.1 - 2.1e-09 37.0 0.1 3.6e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 AMD21286.1 - 9.4e-07 29.0 0.1 4.6e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 AMD21286.1 - 0.0002 21.2 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 AMD21286.1 - 0.00078 19.2 1.1 0.0012 18.6 0.0 1.8 2 0 0 2 2 2 1 Flavivirus DEAD domain SRP54 PF00448.17 AMD21286.1 - 0.0016 17.9 0.0 0.0044 16.4 0.0 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_23 PF13476.1 AMD21286.1 - 0.0091 16.3 0.0 0.061 13.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 AMD21286.1 - 0.013 14.4 0.0 0.027 13.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 AMD21286.1 - 0.045 13.3 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC1 PF03109.11 AMD21287.1 - 4.9e-33 113.6 0.0 1.2e-32 112.4 0.0 1.7 1 0 0 1 1 1 1 ABC1 family RNA_pol_3_Rpc31 PF11705.3 AMD21288.1 - 0.038 13.9 0.0 0.19 11.6 0.0 1.9 1 1 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 WD40 PF00400.27 AMD21289.1 - 3.7e-24 83.6 11.7 2.1e-08 33.7 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat CBS PF00571.23 AMD21290.1 - 1.1e-28 98.7 4.1 1.5e-12 47.0 0.1 4.2 4 0 0 4 4 4 4 CBS domain HTH_9 PF08221.6 AMD21290.1 - 0.37 10.6 2.1 3 7.7 0.1 2.9 4 0 0 4 4 4 0 RNA polymerase III subunit RPC82 helix-turn-helix domain OPT PF03169.10 AMD21291.1 - 2.6e-149 498.5 19.9 2.9e-149 498.4 13.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein BCNT PF07572.7 AMD21292.1 - 1.6e-26 92.0 0.3 1.6e-26 92.0 0.2 2.0 2 0 0 2 2 2 1 Bucentaur or craniofacial development KH_1 PF00013.24 AMD21293.1 - 8.7e-34 114.9 6.0 1.5e-11 43.7 1.0 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 AMD21293.1 - 5.6e-25 86.4 8.6 2.7e-08 33.2 1.2 3.7 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 AMD21293.1 - 3.1e-11 42.6 3.8 0.0055 16.2 0.4 3.5 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 AMD21293.1 - 0.0015 18.3 3.9 0.16 11.7 0.3 3.5 3 0 0 3 3 3 1 NusA-like KH domain KH_4 PF13083.1 AMD21293.1 - 0.0066 16.0 1.8 3.2 7.4 0.0 3.1 2 1 1 3 3 3 2 KH domain SLD3 PF08639.5 AMD21294.1 - 3.5e-62 210.6 21.1 6.4e-62 209.8 14.6 1.4 1 1 0 1 1 1 1 DNA replication regulator SLD3 DUF1546 PF07571.8 AMD21295.1 - 3.1e-31 107.3 0.0 7e-31 106.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1546) TAF PF02969.12 AMD21295.1 - 4.3e-27 93.8 0.4 1.1e-26 92.5 0.3 1.8 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 AMD21295.1 - 0.0048 16.9 1.9 0.0048 16.9 0.1 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CLASP_N PF12348.3 AMD21295.1 - 0.01 15.2 0.3 0.38 10.0 0.1 2.3 2 0 0 2 2 2 0 CLASP N terminal TFIID-31kDa PF02291.10 AMD21295.1 - 0.032 13.9 0.1 0.1 12.3 0.0 1.8 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TAF4 PF05236.9 AMD21295.1 - 0.087 12.0 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF4303 PF14136.1 AMD21295.1 - 0.11 12.1 0.1 0.31 10.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) CENP-S PF15630.1 AMD21295.1 - 0.2 11.8 2.0 1.2 9.4 0.1 2.9 3 0 0 3 3 3 0 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 AMD21295.1 - 0.25 11.4 3.4 0.5 10.4 0.1 2.9 4 0 0 4 4 4 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DASH_Dad3 PF08656.5 AMD21296.1 - 1.2e-24 85.7 2.3 1.3e-24 85.6 1.6 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 WD40 PF00400.27 AMD21297.1 - 4.2e-15 54.9 11.2 8e-06 25.5 0.3 5.9 6 1 0 6 6 6 3 WD domain, G-beta repeat Rax2 PF12768.2 AMD21297.1 - 0.00023 20.4 0.1 0.0034 16.6 0.1 2.2 2 0 0 2 2 2 1 Cortical protein marker for cell polarity eIF2A PF08662.6 AMD21297.1 - 0.0026 17.4 0.1 0.094 12.4 0.0 2.6 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A CUE PF02845.11 AMD21299.1 - 1.3e-08 34.1 0.1 3.2e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 CUE domain AA_permease PF00324.16 AMD21300.1 - 1.5e-48 165.3 38.4 1.5e-48 165.3 26.6 1.6 2 0 0 2 2 2 1 Amino acid permease AA_permease_2 PF13520.1 AMD21300.1 - 1.1e-14 53.8 44.8 1.7e-14 53.2 31.0 1.3 1 0 0 1 1 1 1 Amino acid permease Pox_MCEL PF03291.11 AMD21301.1 - 1.5e-95 319.9 0.1 2.1e-95 319.4 0.0 1.2 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_23 PF13489.1 AMD21301.1 - 8.6e-08 32.0 0.0 1.5e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD21301.1 - 8.9e-08 32.7 0.0 1.8e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD21301.1 - 1.9e-07 31.4 0.2 6.4e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD21301.1 - 5.9e-07 29.7 0.0 1.2e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD21301.1 - 8.9e-07 29.3 0.0 2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD21301.1 - 1.3e-06 28.1 0.9 2.4e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 AMD21301.1 - 0.0037 16.3 0.0 0.0079 15.2 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 AMD21301.1 - 0.008 16.2 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 AMD21301.1 - 0.021 13.9 0.0 0.072 12.1 0.0 1.8 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase NNMT_PNMT_TEMT PF01234.12 AMD21301.1 - 0.03 13.2 0.0 0.073 12.0 0.0 1.6 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family PCMT PF01135.14 AMD21301.1 - 0.095 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.7 AMD21301.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DEAD PF00270.24 AMD21302.1 - 5.3e-43 146.4 0.0 1.9e-42 144.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21302.1 - 1.8e-18 66.1 0.0 5.6e-18 64.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4319 PF14203.1 AMD21302.1 - 0.0054 16.2 0.2 0.027 13.9 0.1 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4319) Helicase_C_2 PF13307.1 AMD21302.1 - 0.027 14.4 0.0 0.09 12.7 0.0 1.9 1 0 0 1 1 1 0 Helicase C-terminal domain Fis1_TPR_N PF14852.1 AMD21302.1 - 0.1 11.9 0.1 0.44 9.8 0.0 2.2 2 0 0 2 2 2 0 Fis1 N-terminal tetratricopeptide repeat EF-hand_7 PF13499.1 AMD21304.1 - 6.9e-14 51.7 0.2 5.2e-09 36.1 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 AMD21304.1 - 2.1e-10 39.5 0.6 0.00087 18.9 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 AMD21304.1 - 2.3e-09 35.8 3.5 0.0008 18.5 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.1 AMD21304.1 - 6.1e-09 35.6 0.0 0.0013 18.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 AMD21304.1 - 1.6e-07 30.8 1.7 2.4e-06 27.0 0.3 2.8 2 1 1 3 3 3 1 EF-hand domain pair Adeno_terminal PF02459.10 AMD21304.1 - 0.13 10.3 0.0 0.25 9.4 0.0 1.5 1 1 0 2 2 2 0 Adenoviral DNA terminal protein EF-hand_5 PF13202.1 AMD21304.1 - 1.6 8.2 3.9 1.7 8.1 0.1 2.8 3 0 0 3 3 3 0 EF hand PAS PF00989.19 AMD21305.1 - 1.1e-12 47.7 0.0 2.4e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.13 AMD21305.1 - 9.9e-07 28.5 9.8 9.9e-07 28.5 6.8 2.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_4 PF08448.5 AMD21305.1 - 0.084 12.9 0.0 0.29 11.1 0.0 2.0 2 0 0 2 2 2 0 PAS fold PAS_9 PF13426.1 AMD21305.1 - 0.087 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 PAS domain tRNA_bind PF01588.15 AMD21306.1 - 4.2e-28 97.0 0.0 7.4e-28 96.2 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain Sugar_tr PF00083.19 AMD21307.1 - 1.1e-90 304.4 21.4 1.3e-90 304.1 14.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD21307.1 - 8.6e-28 97.0 25.8 8.6e-28 97.0 17.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3054 PF11255.3 AMD21307.1 - 5.7 6.8 11.0 0.73 9.6 4.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) Ribosomal_L18e PF00828.14 AMD21308.1 - 1.6e-35 122.2 0.1 2.3e-35 121.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 HD_3 PF13023.1 AMD21309.1 - 3.8e-38 130.8 0.4 4.7e-38 130.5 0.3 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 AMD21309.1 - 6.1e-06 26.2 0.9 1.7e-05 24.7 0.6 1.7 1 1 0 1 1 1 1 HD domain HD_2 PF12917.2 AMD21309.1 - 0.042 13.6 0.3 0.097 12.4 0.1 1.7 1 1 1 2 2 2 0 HD containing hydrolase-like enzyme Glycos_transf_4 PF00953.16 AMD21310.1 - 5.5e-29 101.0 11.3 5.5e-29 101.0 7.8 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 4 WD40 PF00400.27 AMD21311.1 - 2e-34 116.2 20.0 5.6e-09 35.5 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat YmzC PF14157.1 AMD21311.1 - 0.0028 17.4 0.0 0.061 13.1 0.0 2.7 3 0 0 3 3 3 1 YmzC-like protein Apc4_WD40 PF12894.2 AMD21311.1 - 0.031 13.8 0.1 15 5.1 0.0 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain GSHPx PF00255.14 AMD21312.1 - 3e-45 152.0 0.1 4.1e-45 151.5 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 AMD21312.1 - 1.1e-05 25.1 0.0 2.9e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 AMD21312.1 - 1.3e-05 24.8 0.0 2.1e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Redoxin SNF2_N PF00176.18 AMD21313.1 - 4.3e-81 272.0 0.7 8.3e-81 271.0 0.5 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 AMD21313.1 - 2.1e-41 140.3 2.5 2.1e-41 140.3 1.7 3.2 4 0 0 4 4 4 1 SLIDE HAND PF09110.6 AMD21313.1 - 1.4e-31 109.1 0.4 1.4e-31 109.1 0.3 4.4 5 0 0 5 5 5 1 HAND Helicase_C PF00271.26 AMD21313.1 - 5.3e-16 58.2 0.0 1.6e-15 56.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 AMD21313.1 - 2.7e-12 46.1 0.1 6.8e-12 44.8 0.1 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 AMD21313.1 - 8.5e-11 42.0 0.0 2.9e-09 36.9 0.0 3.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 AMD21313.1 - 3.1e-06 26.7 0.0 7.1e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.10 AMD21313.1 - 0.001 18.5 0.1 0.0026 17.1 0.1 1.7 1 0 0 1 1 1 1 DEAD_2 AAA_14 PF13173.1 AMD21313.1 - 0.0097 15.8 1.2 0.04 13.8 0.1 2.7 2 0 0 2 2 2 1 AAA domain WD40 PF00400.27 AMD21314.1 - 1.6e-13 49.9 2.3 0.00016 21.4 0.4 5.9 6 1 0 6 6 6 4 WD domain, G-beta repeat MMR_HSR1 PF01926.18 AMD21315.1 - 1.7e-16 60.1 0.2 4.1e-14 52.5 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD21315.1 - 1.3e-07 31.0 0.2 2.3e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.11 AMD21315.1 - 0.0027 16.9 0.0 0.0052 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 AMD21315.1 - 0.011 15.5 2.4 0.2 11.4 0.0 3.0 3 0 0 3 3 3 0 Dynamin family Miro PF08477.8 AMD21315.1 - 0.042 14.3 0.3 0.35 11.3 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein Use1 PF09753.4 AMD21316.1 - 2e-09 37.2 2.7 3.1e-09 36.6 1.9 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 ABC2_membrane_3 PF12698.2 AMD21316.1 - 0.0038 16.3 0.6 0.0054 15.8 0.4 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF740 PF05340.7 AMD21316.1 - 0.019 13.3 1.7 0.024 13.0 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Nexin_C PF08628.7 AMD21316.1 - 0.029 14.4 0.7 0.069 13.2 0.5 1.6 1 0 0 1 1 1 0 Sorting nexin C terminal DUF1212 PF06738.7 AMD21316.1 - 0.041 13.3 0.0 0.081 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) DUF1993 PF09351.5 AMD21316.1 - 0.096 12.6 2.5 6.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) SMAP PF15477.1 AMD21316.1 - 1.7 8.9 5.5 1.2 9.4 1.7 2.2 2 0 0 2 2 2 0 Small acidic protein family Bystin PF05291.6 AMD21317.1 - 1.1e-123 412.0 0.2 1.6e-123 411.4 0.2 1.2 1 0 0 1 1 1 1 Bystin FGE-sulfatase PF03781.11 AMD21317.1 - 0.092 12.0 0.2 0.16 11.3 0.2 1.3 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 R3H PF01424.17 AMD21317.1 - 1.4 8.7 4.0 28 4.5 0.0 3.5 4 0 0 4 4 4 0 R3H domain RCC1 PF00415.13 AMD21318.1 - 8.8e-67 221.1 0.0 1.4e-11 44.3 0.2 7.7 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 AMD21318.1 - 6.8e-41 137.0 22.9 2.9e-10 39.4 0.0 7.1 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat His_biosynth PF00977.16 AMD21319.1 - 2.1e-44 151.5 0.4 1.1e-43 149.0 0.3 2.2 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 AMD21319.1 - 5.2e-25 88.0 0.0 1.1e-24 86.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.9 AMD21319.1 - 1.8e-10 40.6 0.0 3.7e-10 39.5 0.0 1.6 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.14 AMD21319.1 - 5.7e-07 29.3 0.0 0.0042 16.7 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family Peptidase_C26 PF07722.8 AMD21319.1 - 0.037 13.4 0.0 0.51 9.7 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 ThiG PF05690.9 AMD21319.1 - 0.071 12.1 0.1 0.16 11.0 0.0 1.6 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Peptidase_S51 PF03575.12 AMD21319.1 - 0.072 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S51 BtpA PF03437.10 AMD21319.1 - 0.089 12.0 0.1 1.6 7.9 0.0 2.5 2 1 1 3 3 3 0 BtpA family DAHP_synth_1 PF00793.15 AMD21320.1 - 1.4e-101 338.8 0.0 1.7e-101 338.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Arrestin_N PF00339.24 AMD21321.1 - 0.015 15.1 0.0 0.032 14.0 0.0 1.6 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Homeobox_KN PF05920.6 AMD21322.1 - 1.9e-17 62.6 0.8 3.5e-17 61.8 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 AMD21322.1 - 2.4e-06 27.0 0.4 5.8e-06 25.8 0.3 1.7 1 0 0 1 1 1 1 Homeobox domain RasGEF_N PF00618.15 AMD21322.1 - 0.084 12.9 0.2 0.24 11.5 0.0 1.8 2 0 0 2 2 2 0 RasGEF N-terminal motif EssA PF10661.4 AMD21322.1 - 0.12 12.0 0.3 0.2 11.3 0.2 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA RRM_1 PF00076.17 AMD21323.1 - 5.2e-16 58.0 0.0 7.9e-16 57.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21323.1 - 8.4e-13 48.1 0.0 1.3e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21323.1 - 1.1e-09 37.9 0.0 1.7e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zip PF02535.17 AMD21323.1 - 0.02 13.9 0.1 0.02 13.9 0.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 AMD21323.1 - 4.5 6.5 9.2 6.6 6.0 6.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Metallophos PF00149.23 AMD21324.1 - 4.6e-38 130.6 0.0 6.8e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PHD PF00628.24 AMD21325.1 - 5.1e-10 38.8 7.0 9.1e-10 38.0 4.8 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 AMD21325.1 - 0.87 8.9 5.7 1.5 8.2 4.0 1.4 1 0 0 1 1 1 0 PHD-finger Sec1 PF00995.18 AMD21326.1 - 3.2e-130 435.4 10.0 3.6e-130 435.2 7.0 1.0 1 0 0 1 1 1 1 Sec1 family HHH_6 PF14579.1 AMD21326.1 - 0.037 14.0 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif TMF_DNA_bd PF12329.3 AMD21326.1 - 0.22 11.3 2.7 2.4 8.0 0.7 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding TCO89 PF10452.4 AMD21327.1 - 8.7e-134 447.6 46.4 2e-99 334.1 17.6 2.2 1 1 1 2 2 2 2 TORC1 subunit TCO89 YwqJ-deaminase PF14431.1 AMD21327.1 - 0.026 14.3 0.1 0.063 13.1 0.0 1.7 1 0 0 1 1 1 0 YwqJ-like deaminase UCH_1 PF13423.1 AMD21328.1 - 9.5e-50 169.6 5.7 1.5e-49 169.0 4.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 AMD21328.1 - 4.3e-25 88.8 0.0 1.1e-24 87.5 0.0 1.8 1 0 0 1 1 1 1 Exonuclease UCH PF00443.24 AMD21328.1 - 1.7e-07 30.6 3.9 1.7e-07 30.6 2.7 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.27 AMD21329.1 - 1e-20 72.7 24.6 5.3e-09 35.6 0.0 8.7 9 0 0 9 9 9 6 WD domain, G-beta repeat DoxA PF07680.6 AMD21329.1 - 0.022 14.3 0.1 0.067 12.8 0.0 1.8 1 0 0 1 1 1 0 TQO small subunit DoxA Ribosomal_L36 PF00444.13 AMD21330.1 - 1.4e-20 72.9 6.5 1.7e-20 72.6 4.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.12 AMD21330.1 - 0.0022 17.2 1.4 0.0028 16.9 1.0 1.1 1 0 0 1 1 1 1 Crustacean CHH/MIH/GIH neurohormone family Spc7 PF08317.6 AMD21331.1 - 1.9e-73 246.9 11.9 3.4e-73 246.1 8.2 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF1068 PF06364.7 AMD21331.1 - 0.0074 15.9 0.2 0.017 14.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1068) Spc7_N PF15402.1 AMD21331.1 - 0.027 12.5 11.2 0.39 8.6 0.0 2.8 3 1 0 3 3 3 0 N-terminus of kinetochore NMS complex subunit Spc7 Reo_sigmaC PF04582.7 AMD21331.1 - 0.061 12.4 0.5 0.16 11.1 0.3 1.7 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DivIC PF04977.10 AMD21331.1 - 0.62 9.5 10.1 0.04 13.3 0.4 3.0 3 0 0 3 3 3 0 Septum formation initiator DUF4200 PF13863.1 AMD21331.1 - 0.72 9.8 13.4 0.052 13.4 4.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) BLOC1_2 PF10046.4 AMD21331.1 - 1.3 9.1 13.6 0.33 11.1 0.3 3.3 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.7 AMD21331.1 - 1.3 8.7 11.8 0.051 13.3 3.0 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Syntaxin PF00804.20 AMD21331.1 - 1.3 9.1 14.6 0.3 11.2 3.8 3.4 3 0 0 3 3 3 0 Syntaxin Atg14 PF10186.4 AMD21331.1 - 2.4 7.0 10.6 0.11 11.4 3.0 1.9 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1664 PF07889.7 AMD21331.1 - 7.7 6.3 12.0 0.59 9.9 1.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Nup96 PF12110.3 AMD21332.1 - 1.1e-56 192.1 0.8 1.7e-56 191.4 0.5 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.9 AMD21332.1 - 2.6e-46 156.9 0.1 8.7e-46 155.2 0.0 2.0 2 0 0 2 2 2 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.1 AMD21332.1 - 1.3e-11 44.7 97.1 0.00016 21.8 23.9 3.7 1 1 2 3 3 3 3 Nucleoporin FG repeat region ParA PF10609.4 AMD21333.1 - 1.1e-34 118.1 0.8 1.9e-34 117.3 0.1 1.8 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 AMD21333.1 - 2.4e-16 59.7 0.0 3.8e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 AMD21333.1 - 1.6e-07 30.7 0.0 2.6e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.1 AMD21333.1 - 3e-06 27.2 0.0 2.6e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.10 AMD21333.1 - 5.7e-06 25.6 1.8 0.0003 19.9 0.2 2.9 1 1 1 3 3 3 1 Anion-transporting ATPase DUF258 PF03193.11 AMD21333.1 - 0.011 14.9 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_26 PF13500.1 AMD21333.1 - 0.026 14.1 0.0 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 AMD21333.1 - 0.029 13.7 0.1 0.046 13.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain Fer4_NifH PF00142.13 AMD21333.1 - 0.093 11.8 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family YhjQ PF06564.7 AMD21333.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 YhjQ protein Cep57_CLD PF14073.1 AMD21334.1 - 0.013 15.2 0.2 0.013 15.2 0.2 1.6 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 RRM_6 PF14259.1 AMD21335.1 - 1.3e-28 98.7 1.3 3.8e-07 29.9 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD21335.1 - 5.2e-27 93.2 3.6 1.2e-06 27.9 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21335.1 - 2.9e-23 81.4 3.7 1.3e-06 28.1 0.1 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 AMD21335.1 - 0.0051 16.6 0.3 2.1 8.2 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif Pox_polyA_pol_C PF12629.2 AMD21335.1 - 0.043 13.5 0.0 4.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase C-terminal domain Nup35_RRM_2 PF14605.1 AMD21335.1 - 0.08 12.7 0.1 3 7.6 0.0 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif MF_alpha_N PF05436.6 AMD21336.1 - 4.6e-11 42.2 0.0 7.7e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus IBV_3B PF03622.8 AMD21336.1 - 0.47 10.4 9.7 35 4.4 0.1 4.1 1 1 3 4 4 4 0 IBV 3B protein NAD_kinase PF01513.16 AMD21337.1 - 1.7e-53 181.2 0.1 2.3e-53 180.8 0.1 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 AMD21337.1 - 0.04 13.3 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain UQ_con PF00179.21 AMD21338.1 - 1.7e-16 59.9 0.0 1.9e-16 59.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 AMD21338.1 - 0.075 12.9 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 RWD domain MAD PF05557.8 AMD21339.1 - 3.3e-28 98.2 83.5 4.1e-28 97.9 57.9 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF1735 PF08522.5 AMD21339.1 - 1.7 9.0 9.2 1 9.7 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1735) SNase PF00565.12 AMD21340.1 - 1.1e-23 83.4 0.0 1.8e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue MBOAT PF03062.14 AMD21341.1 - 1e-54 185.8 25.3 1e-54 185.8 17.5 2.2 2 1 1 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family Pkinase PF00069.20 AMD21342.1 - 2.5e-19 69.4 0.1 6.5e-19 68.0 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21342.1 - 1.2e-11 44.2 0.0 2.3e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase ParcG PF10274.4 AMD21342.1 - 0.048 13.5 0.9 0.1 12.4 0.2 1.8 2 0 0 2 2 2 0 Parkin co-regulated protein RRM_1 PF00076.17 AMD21344.1 - 2.6e-10 39.7 0.2 5.5e-10 38.7 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21344.1 - 7.2e-07 29.0 0.0 1.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21344.1 - 0.00065 19.5 0.1 0.0014 18.4 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF544 PF04424.8 AMD21345.1 - 2.3e-27 95.2 0.0 4.2e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) IMD PF08397.6 AMD21345.1 - 0.16 11.2 7.2 0.18 11.1 3.6 1.9 2 0 0 2 2 2 0 IRSp53/MIM homology domain FHA PF00498.21 AMD21346.1 - 3.3e-05 23.9 0.2 6.1e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 FHA domain DUF2407_C PF13373.1 AMD21347.1 - 0.059 13.2 0.0 0.072 13.0 0.0 1.2 1 0 0 1 1 1 0 DUF2407 C-terminal domain NUFIP1 PF10453.4 AMD21348.1 - 3.9e-16 58.3 0.6 1.2e-15 56.7 0.4 1.8 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) APC_CDC26 PF10471.4 AMD21348.1 - 0.041 14.6 0.3 0.041 14.6 0.2 2.4 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit 1 MPC PF03650.8 AMD21349.1 - 2.5e-40 137.1 0.2 2.8e-40 137.0 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Rad9 PF04139.8 AMD21350.1 - 2.5e-13 49.7 0.9 4.7e-07 29.1 0.2 2.2 2 0 0 2 2 2 2 Rad9 Adaptin_N PF01602.15 AMD21351.1 - 2.7e-113 379.0 17.5 3.7e-113 378.6 12.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 AMD21351.1 - 5.5e-08 32.9 0.0 0.31 11.3 0.0 5.3 2 2 1 4 4 4 2 HEAT repeats HEAT PF02985.17 AMD21351.1 - 8.5e-06 25.4 2.0 5.2 7.4 0.0 6.7 8 0 0 8 8 8 1 HEAT repeat Xpo1 PF08389.7 AMD21351.1 - 0.00088 19.2 4.1 1.2 9.0 0.3 4.9 3 2 1 4 4 4 1 Exportin 1-like protein BLVR PF06375.6 AMD21351.1 - 0.006 16.4 1.2 0.006 16.4 0.8 3.0 1 1 1 3 3 3 1 Bovine leukaemia virus receptor (BLVR) DUF2435 PF10363.4 AMD21351.1 - 0.13 12.1 3.3 0.82 9.6 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2435) KxDL PF10241.4 AMD21352.1 - 5.8e-08 32.5 0.6 8.1e-08 32.0 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein CENP-B_N PF04218.8 AMD21352.1 - 0.1 12.0 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain DNA_pol_lambd_f PF10391.4 AMD21352.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda TLD PF07534.11 AMD21353.1 - 2e-28 99.1 0.1 1.6e-27 96.1 0.0 2.0 1 1 0 1 1 1 1 TLD FA_desaturase PF00487.19 AMD21354.1 - 3.1e-38 131.6 21.7 6.2e-38 130.6 15.1 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 AMD21354.1 - 3.1e-10 39.7 0.1 5.8e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DEAD PF00270.24 AMD21355.1 - 1.5e-51 174.2 0.1 5.1e-49 166.0 0.0 2.8 2 1 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21355.1 - 3.6e-30 103.6 0.2 1.2e-28 98.7 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CMS1 PF14617.1 AMD21355.1 - 0.003 16.6 0.0 0.003 16.6 0.0 3.6 2 1 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Mem_trans PF03547.13 AMD21355.1 - 0.13 10.4 2.0 0.16 10.2 1.4 1.3 1 0 0 1 1 1 0 Membrane transport protein Ycf1 PF05758.7 AMD21355.1 - 5 4.6 35.7 9.2 3.8 21.3 2.0 2 0 0 2 2 2 0 Ycf1 MIP-T3 PF10243.4 AMD21355.1 - 5.2 5.4 51.1 7.9 4.8 35.4 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 AA_permease_2 PF13520.1 AMD21356.1 - 1.1e-48 165.7 54.3 1.4e-48 165.4 37.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AMD21356.1 - 1.2e-21 76.6 45.9 1.6e-21 76.2 31.8 1.0 1 0 0 1 1 1 1 Amino acid permease Ribosomal_L30 PF00327.15 AMD21357.1 - 9.2e-20 69.9 1.5 1.8e-19 69.0 1.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.7 AMD21357.1 - 4.1e-18 65.1 17.9 7.7e-18 64.2 12.4 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain HIG_1_N PF04588.8 AMD21358.1 - 0.036 13.8 0.3 0.057 13.1 0.2 1.3 1 0 0 1 1 1 0 Hypoxia induced protein conserved region ADIP PF11559.3 AMD21358.1 - 0.04 13.8 1.3 0.1 12.5 0.9 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DivIC PF04977.10 AMD21358.1 - 0.11 12.0 4.4 0.79 9.2 0.8 2.7 2 0 0 2 2 2 0 Septum formation initiator Ly49 PF08391.5 AMD21358.1 - 0.25 11.4 2.3 0.28 11.3 0.7 1.8 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region HSF_DNA-bind PF00447.12 AMD21359.1 - 1.5e-35 121.5 3.4 3.3e-35 120.3 2.3 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding eIF2A PF08662.6 AMD21360.1 - 1.8e-05 24.5 0.0 3.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A AFT PF08731.6 AMD21361.1 - 4.2e-45 152.5 3.1 4.2e-45 152.5 2.2 2.4 3 0 0 3 3 3 1 Transcription factor AFT DBD_Tnp_Mut PF03108.10 AMD21361.1 - 9.6e-05 21.8 1.9 0.072 12.6 0.1 2.5 2 0 0 2 2 2 2 MuDR family transposase RNA_POL_M_15KD PF02150.11 AMD21362.1 - 5.9e-15 54.6 3.4 5.9e-15 54.6 2.4 2.5 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.13 AMD21362.1 - 2.3e-14 52.6 14.9 3.7e-14 52.0 1.1 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Lar_restr_allev PF14354.1 AMD21362.1 - 0.00057 20.1 3.1 0.0078 16.4 0.2 2.2 2 0 0 2 2 2 1 Restriction alleviation protein Lar DUF2387 PF09526.5 AMD21362.1 - 0.0026 17.6 2.8 0.14 12.1 0.2 2.3 2 0 0 2 2 2 1 Probable metal-binding protein (DUF2387) DZR PF12773.2 AMD21362.1 - 0.068 12.9 9.2 0.13 12.0 0.6 2.5 2 1 0 2 2 2 0 Double zinc ribbon C1_4 PF07975.7 AMD21362.1 - 0.12 12.3 11.2 0.44 10.5 0.8 3.1 2 1 2 4 4 4 0 TFIIH C1-like domain Rubredoxin PF00301.15 AMD21362.1 - 0.13 12.1 3.6 55 3.7 0.0 3.9 4 0 0 4 4 4 0 Rubredoxin GFA PF04828.9 AMD21362.1 - 0.14 12.1 4.1 3.3 7.7 0.2 2.4 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Cytochrome_C7 PF14522.1 AMD21362.1 - 0.14 11.8 3.3 0.53 9.9 0.3 2.3 2 0 0 2 2 2 0 Cytochrome c7 DUF2296 PF10058.4 AMD21362.1 - 0.15 11.7 5.9 0.2 11.4 0.2 2.5 2 1 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Zn_Tnp_IS1595 PF12760.2 AMD21362.1 - 0.9 9.4 12.3 4.7 7.0 2.8 2.8 2 1 1 3 3 3 0 Transposase zinc-ribbon domain Rpr2 PF04032.11 AMD21362.1 - 0.95 9.3 5.7 12 5.8 1.0 2.7 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain IBR PF01485.16 AMD21362.1 - 1 9.2 8.0 1.7 8.5 0.4 2.8 2 1 0 2 2 2 0 IBR domain zf-CHY PF05495.7 AMD21362.1 - 1.4 9.1 8.7 0.84 9.8 0.5 2.4 2 1 1 3 3 3 0 CHY zinc finger HypA PF01155.14 AMD21362.1 - 2.4 7.8 8.3 10 5.8 3.5 2.8 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-UBP PF02148.14 AMD21362.1 - 2.5 8.2 6.1 1.9 8.6 0.3 2.3 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF3795 PF12675.2 AMD21362.1 - 3 8.0 6.0 3.4 7.8 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3795) Zn-ribbon_8 PF09723.5 AMD21362.1 - 3.2 7.7 13.4 4.3 7.3 0.1 3.8 3 1 1 4 4 4 0 Zinc ribbon domain Cytochrom_NNT PF03264.9 AMD21362.1 - 4.1 6.7 8.1 0.095 12.1 0.4 2.0 2 1 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region Ribosomal_L12 PF00542.14 AMD21363.1 - 1.5e-20 72.9 5.7 1.5e-20 72.9 3.9 2.9 3 0 0 3 3 3 1 Ribosomal protein L7/L12 C-terminal domain DUF2267 PF10025.4 AMD21363.1 - 0.0048 16.9 0.1 0.066 13.2 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2267) Bac_DNA_binding PF00216.16 AMD21363.1 - 0.13 12.2 5.3 0.35 10.9 0.4 2.5 1 1 1 2 2 2 0 Bacterial DNA-binding protein Ribosomal_60s PF00428.14 AMD21363.1 - 0.17 12.3 4.6 0.35 11.3 0.4 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pkinase PF00069.20 AMD21364.1 - 5.2e-69 232.2 0.0 6.1e-69 232.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21364.1 - 1.7e-39 135.4 0.0 2.1e-39 135.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21364.1 - 1.4e-05 24.1 0.0 2.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 AMD21364.1 - 0.003 16.8 0.4 0.0044 16.2 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 AMD21364.1 - 0.012 15.0 0.1 0.024 13.9 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 AMD21364.1 - 0.035 13.8 0.0 0.074 12.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 AMD21364.1 - 0.095 11.7 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 AMD21364.1 - 0.12 11.1 0.0 0.22 10.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.20 AMD21365.1 - 7e-41 140.0 1.3 1.7e-40 138.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21365.1 - 8e-15 54.6 0.1 3.3e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 AMD21365.1 - 0.037 12.8 0.1 0.071 11.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Flocculin PF00624.13 AMD21366.1 - 3.3e-226 731.0 634.9 7.8e-13 48.0 13.4 24.4 24 0 0 24 24 24 24 Flocculin repeat PA14_2 PF10528.4 AMD21366.1 - 2.4e-15 56.4 0.8 2.4e-14 53.2 0.6 2.9 1 0 0 1 1 1 1 GLEYA domain Mvb12 PF09452.5 AMD21366.1 - 0.0069 16.5 0.0 8.7e+02 0.1 0.0 6.8 8 0 0 8 8 8 0 ESCRT-I subunit Mvb12 GDPD PF03009.12 AMD21367.1 - 6.9e-29 101.1 0.5 1.3e-21 77.2 0.1 2.1 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.1 AMD21367.1 - 9.3e-05 22.4 0.7 0.00077 19.5 0.2 2.7 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family SBP_bac_1 PF01547.20 AMD21367.1 - 0.056 13.1 0.1 2.8 7.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein DHQS PF01959.11 AMD21367.1 - 0.27 9.8 1.2 0.35 9.4 0.8 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) SCA7 PF08313.7 AMD21368.1 - 2.1e-33 113.7 2.2 2.1e-33 113.7 1.5 2.1 2 0 0 2 2 2 1 SCA7, zinc-binding domain Glycos_transf_1 PF00534.15 AMD21369.1 - 4.2e-28 97.9 0.2 1.8e-27 95.8 0.0 2.1 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 AMD21369.1 - 1.7e-07 31.1 0.0 3.2e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 AMD21369.1 - 0.00021 21.4 0.0 0.00035 20.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 AMD21369.1 - 0.019 15.1 0.0 0.047 13.8 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferases group 1 Radical_SAM PF04055.16 AMD21370.1 - 4.9e-23 82.1 0.1 1.9e-22 80.1 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Wyosine_form PF08608.7 AMD21370.1 - 3.8e-21 74.9 0.0 1.5e-20 73.0 0.0 2.1 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.20 AMD21370.1 - 5.9e-14 52.2 0.0 2e-13 50.5 0.0 1.9 1 1 1 2 2 2 1 Flavodoxin Guanylate_kin PF00625.16 AMD21370.1 - 0.074 12.4 0.1 0.65 9.4 0.0 2.1 2 0 0 2 2 2 0 Guanylate kinase SET PF00856.23 AMD21371.1 - 2.9e-05 24.4 0.0 7.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 SET domain BCA_ABC_TP_C PF12399.3 AMD21371.1 - 0.005 16.4 0.2 0.011 15.3 0.1 1.6 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter Pkinase PF00069.20 AMD21372.1 - 1.2e-70 237.6 0.0 1.7e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21372.1 - 8.3e-45 152.8 0.0 1.1e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21372.1 - 2.2e-05 23.6 0.0 3.8e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 AMD21372.1 - 0.0068 15.7 0.7 0.022 14.1 0.1 2.0 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.4 AMD21372.1 - 0.007 15.7 0.3 0.17 11.1 0.0 2.6 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Kdo PF06293.9 AMD21372.1 - 0.03 13.3 0.0 0.07 12.1 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DEAD PF00270.24 AMD21373.1 - 9.4e-32 109.8 0.0 2.7e-31 108.3 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21373.1 - 2.7e-17 62.4 0.1 2.9e-16 59.0 0.0 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD21373.1 - 3.5e-08 33.4 0.2 2e-07 31.0 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 AMD21373.1 - 3.3e-07 29.3 0.2 5.9e-07 28.5 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SRP72 PF08492.7 AMD21374.1 - 1.8e-14 53.8 4.2 1.8e-14 53.8 2.9 2.0 2 0 0 2 2 1 1 SRP72 RNA-binding domain TPR_12 PF13424.1 AMD21374.1 - 1.3e-06 28.2 6.4 8.3e-06 25.6 1.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD21374.1 - 1.1e-05 24.9 1.6 1.5 8.9 0.3 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 AMD21374.1 - 2.4e-05 24.6 3.7 0.46 10.8 0.8 4.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 AMD21374.1 - 0.00017 21.8 0.3 1.3 9.6 0.0 5.0 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 AMD21374.1 - 0.00062 19.3 3.9 0.034 13.7 0.6 3.5 4 0 0 4 4 4 1 TPR repeat TPR_16 PF13432.1 AMD21374.1 - 0.00079 20.0 0.4 13 6.5 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 AMD21374.1 - 0.0033 17.9 1.8 7.4 7.5 0.3 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 AMD21374.1 - 0.027 14.2 1.7 2 8.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 AMD21374.1 - 0.059 13.5 7.6 1 9.5 0.5 3.5 2 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Apc5 PF12862.2 AMD21374.1 - 0.073 12.9 1.7 0.26 11.1 0.5 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_4 PF07721.9 AMD21374.1 - 0.15 12.6 0.3 0.36 11.3 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.1 AMD21374.1 - 4.4 7.3 5.3 32 4.6 0.6 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat UPF0113 PF03657.8 AMD21375.1 - 2.4e-12 46.7 0.0 3.1e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) PseudoU_synth_1 PF01416.15 AMD21376.1 - 5.4e-22 78.2 0.0 1e-10 41.9 0.0 2.8 2 1 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.4 AMD21376.1 - 0.054 12.9 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) DAP3 PF10236.4 AMD21377.1 - 1e-66 225.0 0.4 1.4e-66 224.6 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.1 AMD21377.1 - 3.7e-07 30.3 0.0 8.4e-07 29.1 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.10 AMD21377.1 - 0.0003 20.5 0.0 0.00078 19.1 0.0 1.7 1 0 0 1 1 1 1 NTPase ArgK PF03308.11 AMD21377.1 - 0.00038 19.3 0.5 0.00092 18.0 0.1 1.7 2 0 0 2 2 2 1 ArgK protein AAA_19 PF13245.1 AMD21377.1 - 0.0011 18.6 0.0 0.0036 17.0 0.0 1.8 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 AMD21377.1 - 0.0017 18.4 0.0 0.015 15.4 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AMD21377.1 - 0.0027 17.1 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 AMD21377.1 - 0.0038 16.4 0.0 0.0088 15.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 AMD21377.1 - 0.0039 16.6 0.0 0.011 15.3 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.7 AMD21377.1 - 0.0044 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_17 PF13207.1 AMD21377.1 - 0.0071 17.1 0.0 0.02 15.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 AMD21377.1 - 0.0088 15.4 0.0 0.024 14.0 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 AMD21377.1 - 0.011 15.6 0.1 0.053 13.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 AMD21377.1 - 0.012 15.9 0.0 0.03 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 AMD21377.1 - 0.013 14.9 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain ABC_tran PF00005.22 AMD21377.1 - 0.04 14.2 0.0 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.18 AMD21377.1 - 0.052 13.5 0.0 0.17 11.8 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.17 AMD21377.1 - 0.07 11.9 0.0 0.14 11.0 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Miro PF08477.8 AMD21377.1 - 0.073 13.5 0.0 0.23 11.9 0.0 2.0 1 0 0 1 1 1 0 Miro-like protein AAA_28 PF13521.1 AMD21377.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain mRNA_cap_enzyme PF01331.14 AMD21378.1 - 2e-55 187.4 0.1 3.9e-55 186.5 0.0 1.5 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 AMD21378.1 - 9.8e-22 77.2 0.9 8.4e-21 74.2 0.6 2.3 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 AMD21378.1 - 2.4e-07 30.3 0.0 1.5e-06 27.7 0.0 2.3 1 1 0 1 1 1 1 ATP dependent DNA ligase domain BAH PF01426.13 AMD21379.1 - 1.4e-14 53.8 0.6 3.5e-14 52.5 0.1 1.8 2 0 0 2 2 2 1 BAH domain zf-HC5HC2H_2 PF13832.1 AMD21379.1 - 6.3e-14 51.9 0.9 6.3e-14 51.9 0.6 5.4 5 1 0 5 5 5 2 PHD-zinc-finger like domain PHD PF00628.24 AMD21379.1 - 2.2e-13 49.6 57.2 8.4e-07 28.5 6.8 5.7 5 1 1 6 6 6 3 PHD-finger zf-HC5HC2H PF13771.1 AMD21379.1 - 1.3e-09 38.0 1.1 1.3e-09 38.0 0.8 5.0 4 1 0 4 4 4 2 PHD-like zinc-binding domain PHD_2 PF13831.1 AMD21379.1 - 1e-06 27.9 5.7 1e-06 27.9 4.0 5.1 6 0 0 6 6 6 3 PHD-finger Myb_DNA-binding PF00249.26 AMD21379.1 - 0.028 14.4 0.0 0.09 12.8 0.0 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain LRR_9 PF14580.1 AMD21380.1 - 9.1e-10 38.3 1.5 1.3e-09 37.8 0.6 1.7 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 AMD21380.1 - 8.2e-08 31.7 13.2 0.0011 18.5 3.0 4.2 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 AMD21380.1 - 0.003 17.2 8.7 0.21 11.3 2.8 3.2 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 AMD21380.1 - 0.015 15.2 11.5 7.8 6.9 0.2 4.5 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 AMD21380.1 - 0.25 11.4 10.4 6.2 7.2 0.2 5.1 4 1 1 5 5 5 0 Leucine Rich repeat HK PF02110.10 AMD21381.1 - 1.9e-81 272.8 1.0 2.6e-81 272.3 0.7 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.12 AMD21381.1 - 9.7e-60 200.7 0.0 1.6e-59 200.0 0.0 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI Phos_pyr_kin PF08543.7 AMD21381.1 - 0.031 13.4 0.6 0.26 10.4 0.4 2.1 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase Ubiq_cyt_C_chap PF03981.7 AMD21382.1 - 5.2e-41 139.8 0.2 7.5e-41 139.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone WAC_Acf1_DNA_bd PF10537.4 AMD21383.1 - 3.6e-36 123.4 1.7 3.6e-36 123.4 1.2 3.0 3 0 0 3 3 3 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.12 AMD21383.1 - 3.8e-13 48.9 3.1 9.6e-12 44.5 0.4 2.8 2 0 0 2 2 2 2 DDT domain WHIM2 PF15613.1 AMD21383.1 - 2.5e-07 30.3 0.1 7.2e-07 28.8 0.1 1.8 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 DUF663 PF04950.7 AMD21384.1 - 4.3e-103 344.3 0.1 4.3e-103 344.3 0.1 2.5 3 0 0 3 3 2 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 AMD21384.1 - 2.1e-27 94.4 0.0 5.7e-27 93.0 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 AMD21384.1 - 1.5e-07 31.0 0.0 2.7e-05 23.6 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 AMD21384.1 - 9.8e-06 25.6 1.0 2.7e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 AMD21384.1 - 1.1e-05 26.2 0.0 1.1e-05 26.2 0.0 3.9 4 2 0 4 4 2 1 AAA domain AAA_22 PF13401.1 AMD21384.1 - 1.5e-05 25.1 0.0 6e-05 23.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 AMD21384.1 - 1.5e-05 25.2 0.1 5.3e-05 23.4 0.0 2.1 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 AMD21384.1 - 1.8e-05 24.6 0.0 7.6e-05 22.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 AMD21384.1 - 2e-05 24.2 0.2 6e-05 22.7 0.1 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 AMD21384.1 - 4.6e-05 23.0 0.2 0.00011 21.8 0.2 1.5 1 0 0 1 1 1 1 Part of AAA domain Miro PF08477.8 AMD21384.1 - 0.0002 21.8 0.1 0.0011 19.4 0.0 2.5 2 0 0 2 2 1 1 Miro-like protein NACHT PF05729.7 AMD21384.1 - 0.00065 19.4 0.0 0.0014 18.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain MMR_HSR1 PF01926.18 AMD21384.1 - 0.00097 19.0 0.1 0.016 15.1 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.1 AMD21384.1 - 0.002 18.0 0.1 0.0088 16.0 0.1 2.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD21384.1 - 0.0032 17.7 0.0 0.0032 17.7 0.0 3.7 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.9 AMD21384.1 - 0.0046 16.6 0.1 0.014 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 AMD21384.1 - 0.0046 17.2 0.8 0.022 15.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter NTPase_1 PF03266.10 AMD21384.1 - 0.0095 15.6 0.3 0.02 14.6 0.2 1.5 1 0 0 1 1 1 1 NTPase RNA_helicase PF00910.17 AMD21384.1 - 0.012 15.7 0.0 0.033 14.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.1 AMD21384.1 - 0.022 14.1 0.0 0.07 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 AMD21384.1 - 0.024 14.2 0.0 0.024 14.2 0.0 3.2 3 0 0 3 3 3 0 AAA domain cobW PF02492.14 AMD21384.1 - 0.044 13.2 0.2 0.044 13.2 0.1 1.8 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 AMD21384.1 - 0.13 11.7 0.0 18 4.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.16 AMD21385.1 - 5.5e-66 221.1 0.0 6.2e-66 220.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 AMD21385.1 - 7.7e-09 36.0 0.0 1.1e-08 35.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 AMD21385.1 - 2.5e-08 33.0 0.6 3e-05 22.8 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 AMD21385.1 - 4.1e-08 32.7 0.0 4.8e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 AMD21385.1 - 3.2e-07 29.7 0.0 4.1e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 AMD21385.1 - 9.7e-06 25.5 0.0 1.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 AMD21385.1 - 0.00011 21.4 0.0 0.00011 21.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 AMD21385.1 - 0.0037 16.7 0.1 0.067 12.6 0.0 2.0 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 AMD21385.1 - 0.051 13.0 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Tegument_dsDNA PF12818.2 AMD21385.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 dsDNA viral tegument protein Cyclin PF08613.6 AMD21386.1 - 1.9e-12 47.7 0.3 3.5e-12 46.9 0.2 1.4 1 0 0 1 1 1 1 Cyclin GH3 PF03321.8 AMD21386.1 - 0.012 14.1 0.0 0.036 12.5 0.0 1.8 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Ribosomal_L1 PF00687.16 AMD21387.1 - 2.2e-46 157.9 1.6 2.6e-46 157.7 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family FtsJ PF01728.14 AMD21388.1 - 3.3e-58 196.6 0.0 4.1e-58 196.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 AMD21388.1 - 2e-05 24.2 0.0 0.017 14.7 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 AMD21388.1 - 6.4e-05 23.4 0.0 0.00018 22.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD21388.1 - 0.00014 21.5 0.0 0.0011 18.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Coatomer_WDAD PF04053.9 AMD21389.1 - 8.3e-160 532.4 0.1 9.7e-159 528.8 0.0 2.0 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.27 AMD21389.1 - 4.5e-47 156.3 7.8 1.1e-11 44.0 0.0 8.0 7 1 0 7 7 7 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 AMD21389.1 - 1.9e-05 24.4 0.1 0.23 11.2 0.0 4.8 1 1 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 AMD21389.1 - 5.9e-05 21.3 3.1 0.17 9.9 0.0 4.1 4 2 2 6 6 6 2 Nucleoporin Nup120/160 TPR_11 PF13414.1 AMD21389.1 - 0.033 13.8 0.1 0.033 13.8 0.0 2.0 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 AMD21389.1 - 0.11 12.4 0.1 0.11 12.4 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 AMD21389.1 - 0.38 10.4 2.5 0.67 9.6 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 AMD21389.1 - 0.61 9.9 2.7 1.7 8.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TRP PF06011.7 AMD21391.1 - 9e-139 462.8 36.9 1.1e-138 462.5 25.6 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 AMD21391.1 - 4.1e-42 143.5 0.1 6.8e-42 142.8 0.1 1.4 1 0 0 1 1 1 1 ML-like domain TMEM237 PF15383.1 AMD21392.1 - 0.49 9.4 4.7 1.4 7.9 3.2 1.8 1 0 0 1 1 1 0 Transmembrane protein 237 UPF0061 PF02696.9 AMD21393.1 - 1.9e-131 438.7 0.0 2.3e-131 438.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family GCR1_C PF12550.3 AMD21394.1 - 1.6e-24 85.5 1.9 3.1e-24 84.6 1.3 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Peptidase_M17 PF00883.16 AMD21394.1 - 0.0031 16.4 0.2 0.93 8.2 0.0 2.2 2 0 0 2 2 2 2 Cytosol aminopeptidase family, catalytic domain SlyX PF04102.7 AMD21394.1 - 0.36 11.2 2.9 0.85 10.0 2.0 1.7 1 0 0 1 1 1 0 SlyX CDV3 PF15359.1 AMD21395.1 - 0.95 9.5 8.3 1.5 8.9 2.6 2.4 1 1 1 2 2 2 0 Carnitine deficiency-associated protein 3 Ndc1_Nup PF09531.5 AMD21395.1 - 4.9 5.4 7.8 6.1 5.1 5.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ARID PF01388.16 AMD21396.1 - 3.1e-23 81.4 0.3 1.8e-22 78.9 0.0 2.5 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain JmjC PF02373.17 AMD21396.1 - 1.6e-17 63.7 0.0 7.4e-08 32.6 0.0 2.9 2 0 0 2 2 2 2 JmjC domain, hydroxylase PLU-1 PF08429.6 AMD21396.1 - 1.4e-10 40.6 2.0 1.6e-10 40.4 0.1 2.0 2 0 0 2 2 2 1 PLU-1-like protein PHD PF00628.24 AMD21396.1 - 2.1e-07 30.4 5.2 4.3e-07 29.5 3.6 1.5 1 0 0 1 1 1 1 PHD-finger Eclosion PF04736.7 AMD21396.1 - 0.054 12.9 0.1 0.25 10.8 0.0 2.2 2 0 0 2 2 2 0 Eclosion hormone Cation_efflux PF01545.16 AMD21397.1 - 1e-47 162.5 2.2 1.5e-47 162.0 1.5 1.2 1 0 0 1 1 1 1 Cation efflux family Polysacc_synt_4 PF04669.8 AMD21398.1 - 1.7e-21 76.4 1.3 7e-20 71.2 0.9 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Cullin_binding PF03556.10 AMD21398.1 - 0.0075 16.3 0.2 0.014 15.4 0.1 1.5 1 1 0 1 1 1 1 Cullin binding YcbB PF08664.5 AMD21398.1 - 0.078 12.7 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 YcbB domain MoCF_biosynth PF00994.19 AMD21399.1 - 5.5e-34 116.6 0.0 9e-34 115.9 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain ABC_tran PF00005.22 AMD21400.1 - 5.3e-46 156.3 0.0 4.9e-25 88.4 0.0 4.2 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 AMD21400.1 - 4.9e-16 59.5 3.2 5e-07 29.9 0.0 3.9 2 2 0 3 3 3 3 AAA domain SMC_N PF02463.14 AMD21400.1 - 4.1e-12 45.8 0.0 0.0032 16.7 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.19 AMD21400.1 - 2.5e-08 33.4 3.6 5.5e-08 32.3 2.5 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_29 PF13555.1 AMD21400.1 - 2.7e-07 30.0 0.5 0.017 14.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.1 AMD21400.1 - 5e-07 29.1 0.5 0.23 10.4 0.0 3.6 2 1 1 3 3 3 2 AAA ATPase domain AAA_23 PF13476.1 AMD21400.1 - 8.8e-07 29.4 0.9 0.017 15.4 0.0 3.1 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.18 AMD21400.1 - 3.1e-06 27.1 0.0 0.032 14.1 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 AMD21400.1 - 4.3e-06 27.2 0.0 0.014 15.9 0.0 3.0 2 1 0 2 2 2 2 Miro-like protein DUF258 PF03193.11 AMD21400.1 - 4.6e-06 25.9 0.3 0.02 14.0 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 AMD21400.1 - 7.4e-06 26.1 0.2 0.028 14.5 0.0 3.4 3 1 0 3 3 2 2 AAA domain AAA_17 PF13207.1 AMD21400.1 - 4.4e-05 24.2 0.0 0.41 11.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 AMD21400.1 - 5e-05 22.8 2.8 0.64 9.4 0.1 4.0 4 0 0 4 4 4 2 AAA-like domain NACHT PF05729.7 AMD21400.1 - 0.00014 21.5 0.2 0.076 12.6 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.1 AMD21400.1 - 0.00025 21.0 0.0 0.13 12.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 AMD21400.1 - 0.0008 19.1 0.0 1.7 8.3 0.1 3.0 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.1 AMD21400.1 - 0.00087 19.1 0.2 2 8.4 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ArgK PF03308.11 AMD21400.1 - 0.00091 18.0 0.1 0.82 8.3 0.0 2.5 2 0 0 2 2 2 2 ArgK protein DUF87 PF01935.12 AMD21400.1 - 0.0021 17.9 5.7 0.36 10.6 0.1 4.4 4 0 0 4 4 4 1 Domain of unknown function DUF87 AAA_30 PF13604.1 AMD21400.1 - 0.0034 16.9 0.1 2.1 7.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 AMD21400.1 - 0.0037 17.1 0.0 3.5 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 AMD21400.1 - 0.0045 15.9 0.4 0.28 10.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.17 AMD21400.1 - 0.0055 16.8 0.1 2.5 8.3 0.0 2.9 2 0 0 2 2 2 1 RNA helicase FtsK_SpoIIIE PF01580.13 AMD21400.1 - 0.006 16.0 0.1 0.65 9.4 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_13 PF13166.1 AMD21400.1 - 0.0093 14.4 0.2 1 7.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 AMD21400.1 - 0.013 15.3 0.0 2.2 8.1 0.0 3.1 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 AMD21400.1 - 0.014 15.1 2.8 0.38 10.5 0.0 3.3 4 1 0 4 4 2 0 Dynamin family DUF3584 PF12128.3 AMD21400.1 - 0.015 12.7 0.8 1.7 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_25 PF13481.1 AMD21400.1 - 0.029 13.7 0.0 9.4 5.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 AMD21400.1 - 0.08 13.1 0.2 13 6.0 0.0 3.6 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.4 AMD21400.1 - 0.083 12.3 0.1 8.1 5.9 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 AMD21400.1 - 2.5 8.0 5.2 9 6.2 0.1 3.6 3 1 0 3 3 3 0 AAA ATPase domain Glycos_transf_2 PF00535.21 AMD21402.1 - 2.9e-25 88.9 0.0 4.3e-25 88.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AMD21402.1 - 3.8e-09 36.6 0.0 5.4e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 AMD21402.1 - 0.0054 17.0 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 AMD21402.1 - 0.0066 15.5 0.0 0.0088 15.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 mRNA_triPase PF02940.10 AMD21403.1 - 2.7e-58 197.2 1.6 4.7e-58 196.4 1.1 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Tuberin PF03542.11 AMD21404.1 - 0.0035 16.4 1.1 0.0035 16.4 0.8 1.4 2 0 0 2 2 2 1 Tuberin Med15 PF09606.5 AMD21404.1 - 4.6 5.3 42.0 5.6 5.0 29.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal zf-C2H2 PF00096.21 AMD21405.1 - 1.5e-10 40.7 8.4 7e-05 22.9 0.9 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD21405.1 - 8.2e-10 38.4 2.1 8.2e-10 38.4 1.4 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 AMD21405.1 - 1e-09 38.0 7.4 0.00023 21.2 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 AMD21405.1 - 0.00073 19.6 3.5 0.035 14.3 0.3 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 AMD21405.1 - 0.0015 18.6 0.8 0.0015 18.6 0.5 2.9 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.3 AMD21405.1 - 0.014 15.5 0.4 0.014 15.5 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding RRN7 PF11781.3 AMD21405.1 - 0.02 14.3 0.1 0.039 13.4 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C2H2_6 PF13912.1 AMD21405.1 - 0.031 14.1 1.4 0.049 13.5 0.1 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger BolA PF01722.13 AMD21405.1 - 0.11 12.5 0.6 0.2 11.6 0.4 1.4 1 0 0 1 1 1 0 BolA-like protein ketoacyl-synt PF00109.21 AMD21406.1 - 7.6e-19 68.1 0.0 1.4e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain adh_short_C2 PF13561.1 AMD21406.1 - 1.6e-16 60.8 0.0 4.5e-16 59.3 0.0 1.8 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ACPS PF01648.15 AMD21406.1 - 5.1e-16 58.5 0.0 1.2e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 AMD21406.1 - 1e-11 44.7 0.9 2.4e-11 43.5 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.20 AMD21406.1 - 1.4e-05 25.0 0.0 3.8e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AMD21406.1 - 0.00053 19.7 0.1 0.002 17.8 0.0 2.0 2 0 0 2 2 2 1 KR domain SNARE PF05739.14 AMD21407.1 - 5.3e-15 54.8 7.4 1.7e-14 53.2 5.1 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.20 AMD21407.1 - 2.5e-05 24.3 18.3 0.0001 22.4 5.0 2.4 2 1 0 2 2 2 2 Syntaxin Rifin_STEVOR PF02009.11 AMD21407.1 - 0.0012 18.6 4.6 0.0012 18.6 3.2 1.6 1 1 1 2 2 2 1 Rifin/stevor family Synaptobrevin PF00957.16 AMD21407.1 - 0.004 16.7 2.6 0.004 16.7 1.8 2.1 2 1 0 2 2 2 1 Synaptobrevin Thr_dehydrat_C PF00585.13 AMD21407.1 - 0.0064 16.0 2.9 0.0085 15.6 0.0 2.5 3 0 0 3 3 3 1 C-terminal regulatory domain of Threonine dehydratase DUF3753 PF12575.3 AMD21407.1 - 0.0069 16.1 2.6 1.3 8.8 0.6 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3753) T2SF PF00482.18 AMD21407.1 - 0.025 14.5 0.6 0.025 14.5 0.4 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF4375 PF14300.1 AMD21407.1 - 0.32 10.9 6.3 0.058 13.3 0.8 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4375) OppC_N PF12911.2 AMD21407.1 - 0.33 10.3 1.7 0.62 9.4 1.2 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF1664 PF07889.7 AMD21407.1 - 0.65 9.8 8.7 0.33 10.7 1.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Med11 PF10280.4 AMD21407.1 - 1.3 9.0 15.9 9.6 6.2 11.0 2.2 1 1 0 1 1 1 0 Mediator complex protein ISG65-75 PF11727.3 AMD21407.1 - 1.3 7.9 13.5 0.066 12.2 1.7 2.3 2 0 0 2 2 2 0 Invariant surface glycoprotein Spc7 PF08317.6 AMD21407.1 - 1.8 7.1 21.7 0.071 11.7 3.4 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF4094 PF13334.1 AMD21407.1 - 3.5 8.0 9.0 0.35 11.2 0.2 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF4094) Fcf2 PF08698.6 AMD21407.1 - 3.7 7.6 7.1 0.77 9.8 0.3 2.9 2 1 2 4 4 4 0 Fcf2 pre-rRNA processing Allexi_40kDa PF05549.6 AMD21407.1 - 5.2 6.2 7.7 1.8 7.7 0.7 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF3708 PF12501.3 AMD21407.1 - 7.5 6.3 11.7 1.6 8.5 1.6 2.7 1 1 2 3 3 3 0 Phosphate ATP-binding cassette transporter Sugar_tr PF00083.19 AMD21408.1 - 1e-105 353.9 26.7 1.2e-105 353.6 18.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD21408.1 - 2.6e-25 88.8 30.7 1.3e-24 86.5 16.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2 PF04550.7 AMD21408.1 - 0.07 13.2 1.5 0.3 11.1 1.1 2.1 1 0 0 1 1 1 0 Phage holin family 2 Mis14 PF08641.7 AMD21409.1 - 1e-23 83.9 5.3 2.1e-23 82.9 3.7 1.6 1 0 0 1 1 1 1 Kinetochore protein Mis14 like DUF1804 PF08822.6 AMD21409.1 - 0.001 18.8 0.3 0.002 17.9 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1804) DUF4145 PF13643.1 AMD21409.1 - 0.047 13.5 0.8 0.28 11.0 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4145) Gemini_AL1_M PF08283.6 AMD21409.1 - 0.073 12.9 0.3 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 Geminivirus rep protein central domain ThiS PF02597.15 AMD21409.1 - 0.15 12.4 1.1 0.44 11.0 0.1 2.2 2 1 0 2 2 2 0 ThiS family Peptidase_M41 PF01434.13 AMD21409.1 - 1.1 8.7 5.7 5.8 6.3 0.2 2.9 1 1 2 3 3 3 0 Peptidase family M41 ATP-synt_C PF00137.16 AMD21410.1 - 5.5e-26 90.2 28.3 3.6e-15 55.6 3.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF3265 PF11665.3 AMD21410.1 - 1.4 8.8 5.6 5 7.0 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3265) TIP49 PF06068.8 AMD21411.1 - 3.3e-176 585.8 4.0 4e-176 585.5 2.7 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 AMD21411.1 - 7.2e-09 35.9 0.6 5.6e-06 26.5 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD21411.1 - 2.1e-06 26.9 3.7 0.00075 18.6 0.0 2.8 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus DnaB_C PF03796.10 AMD21411.1 - 3e-06 26.3 0.1 7.8e-06 24.9 0.1 1.7 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.1 AMD21411.1 - 8.1e-06 26.0 0.1 0.052 13.6 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_14 PF13173.1 AMD21411.1 - 0.00016 21.5 0.5 2.6 7.9 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.1 AMD21411.1 - 0.00023 21.1 0.3 0.0021 18.0 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 AMD21411.1 - 0.00061 19.2 0.2 0.0012 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 AMD21411.1 - 0.0066 16.4 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD21411.1 - 0.024 14.3 0.1 0.049 13.3 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain Mg_chelatase PF01078.16 AMD21411.1 - 0.025 13.7 1.1 0.16 11.1 0.2 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TFIID_20kDa PF03847.8 AMD21411.1 - 0.027 14.7 0.1 0.073 13.3 0.1 1.7 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A AAA_17 PF13207.1 AMD21411.1 - 0.04 14.7 0.0 0.11 13.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 AMD21411.1 - 0.056 13.1 1.3 2 8.1 0.0 3.1 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 AMD21411.1 - 0.093 12.6 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain eIF-5_eIF-2B PF01873.12 AMD21413.1 - 2.8e-44 149.7 0.4 4.7e-44 149.0 0.2 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.10 AMD21413.1 - 0.047 13.3 2.6 0.094 12.3 0.0 2.8 3 1 1 4 4 4 0 Translation initiation factor IF-2, N-terminal region TF_Zn_Ribbon PF08271.7 AMD21413.1 - 0.1 11.9 0.2 0.24 10.7 0.1 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding DUF3921 PF13060.1 AMD21413.1 - 0.1 12.4 0.1 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3921) Tox-REase-2 PF15646.1 AMD21413.1 - 0.19 11.5 2.7 0.18 11.6 0.7 1.9 2 1 0 2 2 2 0 Restriction endonuclease fold toxin 2 Ank_2 PF12796.2 AMD21414.1 - 5.5e-18 65.0 0.1 9e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 AMD21414.1 - 2e-17 62.0 0.1 1.1e-08 34.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 AMD21414.1 - 1.9e-16 59.7 0.2 1.2e-08 34.9 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 AMD21414.1 - 4.8e-14 51.0 0.2 3.7e-06 26.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 AMD21414.1 - 1.4e-11 44.5 0.1 3e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) DUF2435 PF10363.4 AMD21415.1 - 1.7e-25 88.7 0.4 1.7e-25 88.7 0.3 3.8 5 0 0 5 5 5 1 Protein of unknown function (DUF2435) DUF2411 PF10304.4 AMD21415.1 - 1.8e-06 27.3 0.5 4.8e-06 25.9 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2411) HEAT_2 PF13646.1 AMD21415.1 - 0.00084 19.5 0.4 0.11 12.7 0.0 3.6 3 0 0 3 3 3 1 HEAT repeats MCM_N PF14551.1 AMD21415.1 - 0.51 10.8 5.7 1.1 9.7 0.5 3.3 3 1 0 3 3 3 0 MCM N-terminal domain HSP90 PF00183.13 AMD21416.1 - 1.3e-253 842.3 37.5 1.5e-253 842.0 26.0 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.21 AMD21416.1 - 3.9e-12 45.8 0.0 8.4e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 AMD21416.1 - 3.8e-11 42.7 0.1 3.8e-11 42.7 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1510 PF07423.6 AMD21416.1 - 3.7 6.8 21.5 0.087 12.1 9.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) TBCC PF07986.7 AMD21417.1 - 2.1e-06 27.1 10.3 6.3e-06 25.5 7.1 1.8 1 1 0 1 1 1 1 Tubulin binding cofactor C Beta-lactamase2 PF13354.1 AMD21417.1 - 0.09 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase enzyme family RasGAP_C PF03836.10 AMD21418.1 - 1.2e-18 67.1 0.3 3.6e-18 65.6 0.2 1.8 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.14 AMD21418.1 - 2.3e-15 56.8 0.9 7.3e-15 55.1 0.7 1.9 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase CH PF00307.26 AMD21418.1 - 4e-09 36.4 0.0 2.1e-08 34.1 0.0 2.3 1 0 0 1 1 1 1 Calponin homology (CH) domain IQ PF00612.22 AMD21418.1 - 0.00018 20.8 36.4 0.16 11.6 0.5 10.3 11 0 0 11 11 11 3 IQ calmodulin-binding motif Ribosomal_L32p PF01783.18 AMD21420.1 - 0.026 14.6 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 Ribosomal L32p protein family RINGv PF12906.2 AMD21420.1 - 0.058 13.4 8.2 0.16 12.0 5.7 1.8 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 AMD21420.1 - 0.66 9.9 7.9 2.3 8.2 3.9 2.6 2 0 0 2 2 2 0 FANCL C-terminal domain TROVE PF05731.6 AMD21421.1 - 0.029 13.1 5.6 0.9 8.2 2.3 2.3 2 0 0 2 2 2 0 TROVE domain UAA PF08449.6 AMD21422.1 - 5.8e-71 238.8 12.8 7.3e-71 238.5 8.8 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 AMD21422.1 - 1.7e-11 44.0 6.2 1.7e-11 44.0 4.3 2.1 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 AMD21422.1 - 2e-09 37.5 5.0 2e-09 37.5 3.5 3.5 1 1 3 4 4 4 1 EamA-like transporter family DUF914 PF06027.7 AMD21422.1 - 0.00013 20.9 4.8 0.00017 20.5 3.3 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EmrE PF13536.1 AMD21422.1 - 0.00041 20.5 7.2 0.00041 20.5 5.0 2.7 3 1 0 3 3 3 1 Multidrug resistance efflux transporter Abhydrolase_9_N PF15420.1 AMD21422.1 - 0.009 15.7 2.4 0.011 15.5 0.7 1.8 2 0 0 2 2 2 1 Alpha/beta-hydrolase family N-terminus Rhomboid PF01694.17 AMD21423.1 - 2.1e-15 57.0 14.2 2.1e-15 57.0 9.9 1.4 2 0 0 2 2 2 1 Rhomboid family Ribosomal_S17 PF00366.15 AMD21424.1 - 5.4e-16 58.3 2.1 5.4e-16 58.3 1.4 2.1 2 0 0 2 2 2 1 Ribosomal protein S17 RNA_pol_Rpb1_5 PF04998.12 AMD21424.1 - 7.2 5.7 7.1 8.4 5.5 4.6 1.3 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 WD40 PF00400.27 AMD21425.1 - 1.1e-19 69.4 18.5 7.1e-09 35.2 0.4 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat PHD PF00628.24 AMD21426.1 - 0.028 14.0 9.5 0.063 12.9 6.6 1.8 1 1 0 1 1 1 0 PHD-finger RQC PF09382.5 AMD21427.1 - 3.6e-26 90.9 0.4 8.8e-26 89.6 0.3 1.7 1 0 0 1 1 1 1 RQC domain DEAD PF00270.24 AMD21427.1 - 6.6e-22 77.7 0.0 1.6e-21 76.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21427.1 - 2.7e-20 72.0 0.0 2.8e-18 65.5 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Helicase_Sgs1 PF11408.3 AMD21427.1 - 1.9e-09 37.2 0.6 7.2e-09 35.3 0.4 2.0 1 0 0 1 1 1 1 Sgs1 RecQ helicase RabGAP-TBC PF00566.13 AMD21428.1 - 3.8e-51 173.6 0.7 1.3e-50 171.8 0.5 1.9 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ATG16 PF08614.6 AMD21428.1 - 3.1 7.5 21.8 0.13 12.0 6.4 3.1 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Ribosomal_L28 PF00830.14 AMD21429.1 - 1.8e-22 78.9 0.6 3e-22 78.1 0.4 1.4 1 0 0 1 1 1 1 Ribosomal L28 family Sec66 PF09802.4 AMD21429.1 - 0.089 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Ribosomal_L36e PF01158.13 AMD21430.1 - 2.8e-37 126.6 3.5 3.1e-37 126.4 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Rsc14 PF08586.5 AMD21431.1 - 0.08 13.4 0.4 0.11 12.9 0.3 1.3 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit V-SNARE PF05008.10 AMD21433.1 - 1.1e-19 70.3 2.6 1.1e-19 70.3 1.8 2.3 3 0 0 3 3 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 AMD21433.1 - 1.7e-16 60.0 3.0 1.7e-16 60.0 2.1 3.9 3 1 1 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 AMD21433.1 - 0.00072 19.2 1.6 0.00072 19.2 1.1 2.5 1 1 3 4 4 4 1 Sec20 YqjK PF13997.1 AMD21433.1 - 0.0088 16.1 7.9 0.1 12.8 0.1 2.9 3 0 0 3 3 2 2 YqjK-like protein DUF106 PF01956.11 AMD21433.1 - 0.023 14.2 0.1 0.28 10.7 0.1 2.1 1 1 0 1 1 1 0 Integral membrane protein DUF106 DUF677 PF05055.7 AMD21433.1 - 0.031 12.9 1.1 1.5 7.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF677) MRP-S26 PF14943.1 AMD21433.1 - 0.047 13.2 3.9 0.057 12.9 2.0 1.6 1 1 0 1 1 1 0 Mitochondrial ribosome subunit S26 DUF2096 PF09869.4 AMD21433.1 - 0.072 12.9 1.7 7.6 6.3 0.2 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) TroA PF01297.12 AMD21433.1 - 0.086 12.0 0.9 0.36 10.0 0.0 2.2 3 0 0 3 3 3 0 Periplasmic solute binding protein family SPX PF03105.14 AMD21433.1 - 0.088 12.5 4.0 0.11 12.3 2.8 1.1 1 0 0 1 1 1 0 SPX domain HrpB7 PF09486.5 AMD21433.1 - 0.096 12.6 8.2 0.66 9.8 4.2 2.1 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF3837 PF12939.2 AMD21433.1 - 0.13 12.3 0.8 0.38 10.7 0.5 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF3837) RasGAP_C PF03836.10 AMD21433.1 - 0.13 11.9 5.4 0.5 10.0 0.6 2.7 2 1 0 2 2 2 0 RasGAP C-terminus Type_III_YscX PF09474.5 AMD21433.1 - 0.16 12.0 5.7 0.29 11.1 2.8 2.2 1 1 1 2 2 2 0 Type III secretion system YscX (type_III_YscX) Cupin_4 PF08007.7 AMD21433.1 - 0.18 11.0 5.5 0.09 12.0 2.2 1.7 1 1 1 2 2 2 0 Cupin superfamily protein DUF3753 PF12575.3 AMD21433.1 - 0.19 11.5 1.8 3.6 7.4 0.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) Fusion_gly PF00523.13 AMD21433.1 - 0.3 9.1 4.8 0.095 10.7 0.6 2.0 1 1 0 2 2 2 0 Fusion glycoprotein F0 Mnd1 PF03962.10 AMD21433.1 - 0.37 10.4 9.8 0.36 10.4 2.8 2.1 1 1 1 2 2 2 0 Mnd1 family FlaC_arch PF05377.6 AMD21433.1 - 0.37 10.7 2.5 0.96 9.3 0.1 2.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Retrotrans_gag PF03732.12 AMD21433.1 - 0.59 10.2 5.3 1.4 9.0 0.4 2.9 2 1 1 3 3 3 0 Retrotransposon gag protein Nsp1_C PF05064.8 AMD21433.1 - 1.5 8.4 6.3 0.43 10.2 0.4 2.7 1 1 0 2 2 2 0 Nsp1-like C-terminal region DUF4071 PF13281.1 AMD21433.1 - 1.8 7.3 9.3 0.23 10.2 1.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4071) Snapin_Pallidin PF14712.1 AMD21433.1 - 3.2 8.1 11.0 0.86 9.9 3.1 2.7 2 2 0 2 2 2 0 Snapin/Pallidin APG6 PF04111.7 AMD21433.1 - 4 6.3 10.7 6.5 5.7 4.2 1.8 1 1 1 2 2 2 0 Autophagy protein Apg6 Fib_alpha PF08702.5 AMD21433.1 - 4.1 7.5 11.0 3.9 7.5 2.2 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.6 AMD21433.1 - 5.3 7.5 8.7 10 6.5 1.7 3.4 1 1 0 2 2 2 0 Syntaxin 6, N-terminal Sas10_Utp3 PF04000.10 AMD21433.1 - 6.5 7.0 9.3 12 6.1 1.9 3.5 1 1 2 3 3 3 0 Sas10/Utp3/C1D family DUF745 PF05335.8 AMD21433.1 - 7.7 5.9 7.5 0.97 8.9 0.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Fer2 PF00111.22 AMD21434.1 - 1.1e-12 47.5 2.1 1.4e-12 47.1 1.4 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Laminin_II PF06009.7 AMD21435.1 - 0.22 11.2 18.3 0.15 11.8 2.6 3.4 2 2 1 3 3 3 0 Laminin Domain II SAGA-Tad1 PF12767.2 AMD21436.1 - 5e-72 242.5 0.5 7.1e-72 242.0 0.3 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.9 AMD21436.1 - 0.033 13.4 0.1 0.054 12.7 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family BBP1_C PF15272.1 AMD21437.1 - 2.8e-44 151.0 28.3 2.8e-44 151.0 19.6 1.7 2 0 0 2 2 2 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.1 AMD21437.1 - 3.4e-28 98.8 2.2 3.4e-28 98.8 1.5 2.5 2 1 0 2 2 2 1 Spindle pole body component BBP1, Mps2-binding protein DUF1617 PF07761.7 AMD21437.1 - 0.013 15.5 4.5 0.024 14.6 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1617) DUF2868 PF11067.3 AMD21437.1 - 0.26 10.3 1.8 0.33 10.0 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2868) DUF2779 PF11074.3 AMD21437.1 - 0.34 10.9 6.0 0.55 10.2 4.0 1.4 1 1 0 1 1 1 0 Domain of unknown function(DUF2779) Fib_alpha PF08702.5 AMD21437.1 - 1 9.4 13.0 1.4 9.0 8.4 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Cyclin_N PF00134.18 AMD21439.1 - 6.9e-36 122.6 0.0 1.3e-35 121.7 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Rot1 PF10681.4 AMD21440.1 - 3.8e-94 313.9 0.0 4.4e-94 313.7 0.0 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal VHS PF00790.14 AMD21441.1 - 2.8e-37 127.5 0.5 6.1e-37 126.3 0.3 1.6 1 0 0 1 1 1 1 VHS domain FYVE PF01363.16 AMD21441.1 - 1e-18 67.0 4.0 2.9e-18 65.5 2.8 1.8 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.15 AMD21441.1 - 0.19 11.3 20.6 0.061 12.9 0.4 4.9 5 0 0 5 5 5 0 Ubiquitin interaction motif zf-AN1 PF01428.11 AMD21441.1 - 0.22 11.4 7.9 0.59 10.0 5.5 1.8 1 0 0 1 1 1 0 AN1-like Zinc finger Ribosomal_S21 PF01165.15 AMD21441.1 - 0.92 9.0 5.8 2.3 7.7 4.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S21 XPA_C PF05181.7 AMD21442.1 - 6.9e-26 89.5 0.2 1.7e-25 88.3 0.1 1.7 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.13 AMD21442.1 - 0.033 13.8 2.0 0.05 13.2 0.2 2.0 2 0 0 2 2 2 0 XPA protein N-terminal Autophagy_N PF03986.8 AMD21443.1 - 1.1e-40 138.7 3.1 1.3e-40 138.5 0.1 2.0 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 AMD21443.1 - 5.7e-23 80.8 0.2 3.9e-22 78.2 0.1 2.4 3 0 0 3 3 3 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 AMD21443.1 - 7.2e-15 53.7 1.1 1.5e-14 52.7 0.8 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal DUF1940 PF09155.5 AMD21443.1 - 0.0065 16.3 0.1 0.012 15.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1940) LCAT PF02450.10 AMD21444.1 - 5.4e-125 417.3 0.0 6.7e-125 417.0 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_5 PF12695.2 AMD21444.1 - 0.0047 16.6 0.0 0.018 14.7 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 AMD21444.1 - 0.078 12.8 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_2 PF01674.13 AMD21444.1 - 0.11 11.7 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) ERG2_Sigma1R PF04622.7 AMD21445.1 - 8.8e-81 270.2 2.1 1e-80 270.0 1.4 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Med9 PF07544.8 AMD21446.1 - 4e-20 71.3 0.4 5.5e-20 70.8 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Porin_3 PF01459.17 AMD21447.1 - 3.3e-86 288.9 0.4 3.9e-86 288.7 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin Inp1 PF12634.2 AMD21448.1 - 6.6e-23 80.9 0.1 1.5e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 PFK PF00365.15 AMD21449.1 - 3.6e-165 547.8 2.6 2.1e-123 410.7 0.9 2.1 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.14 AMD21449.1 - 0.12 11.8 0.4 0.26 10.8 0.3 1.5 1 0 0 1 1 1 0 UvrB/uvrC motif Glyoxalase PF00903.20 AMD21450.1 - 3e-35 120.9 0.6 2.6e-18 66.2 0.0 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 AMD21450.1 - 2.2e-25 89.3 0.0 1.5e-11 44.8 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 AMD21450.1 - 2.5e-08 33.8 0.0 0.00027 20.8 0.0 2.9 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.1 AMD21450.1 - 0.00081 19.0 0.0 0.98 9.0 0.0 2.4 2 0 0 2 2 2 2 CppA N-terminal Glyoxalase_3 PF13468.1 AMD21450.1 - 0.003 17.4 0.0 0.0069 16.3 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain RRM_1 PF00076.17 AMD21450.1 - 0.024 14.2 0.1 12 5.6 0.0 3.1 2 1 1 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lectin_C PF00059.16 AMD21450.1 - 0.14 12.7 0.0 0.73 10.4 0.0 2.2 2 0 0 2 2 2 0 Lectin C-type domain OB_NTP_bind PF07717.11 AMD21451.1 - 5.9e-19 67.9 0.0 1.5e-18 66.6 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 AMD21451.1 - 2.9e-15 56.1 0.0 1e-14 54.3 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 AMD21451.1 - 1.2e-13 50.7 0.0 3.4e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AMD21451.1 - 3.8e-06 26.5 0.1 9.1e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 AMD21451.1 - 0.00018 20.5 0.0 0.00036 19.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 AMD21451.1 - 0.00019 21.5 0.2 0.0013 18.9 0.1 2.4 2 1 0 2 2 2 1 AAA domain ResIII PF04851.10 AMD21451.1 - 0.0012 18.7 0.1 0.083 12.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SRP54 PF00448.17 AMD21451.1 - 0.066 12.6 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.1 AMD21451.1 - 0.069 12.9 0.1 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain PRK PF00485.13 AMD21452.1 - 2.9e-61 206.4 0.0 4.3e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.1 AMD21452.1 - 1.1e-36 125.9 0.1 1.8e-36 125.3 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.1 AMD21452.1 - 3.9e-09 36.8 0.0 1.1e-08 35.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD21452.1 - 8e-09 36.3 0.0 1.8e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain CPT PF07931.7 AMD21452.1 - 0.00029 20.5 0.0 0.00059 19.4 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.7 AMD21452.1 - 0.0071 15.4 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 AMD21452.1 - 0.013 15.4 0.0 0.035 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain SPX PF03105.14 AMD21453.1 - 5.8e-39 134.5 10.6 2e-38 132.7 7.3 1.9 1 1 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 AMD21453.1 - 6.4e-23 81.3 42.4 1e-22 80.7 29.4 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 AMD21453.1 - 2.9e-13 49.1 21.0 2.9e-13 49.1 14.6 2.2 1 1 1 2 2 2 2 Citrate transporter DUF1708 PF08101.6 AMD21455.1 - 3.9e-69 233.5 3.0 6.2e-69 232.8 2.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Dus PF01207.12 AMD21456.1 - 1.1e-47 162.4 0.0 2.5e-47 161.2 0.0 1.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) ACC_central PF08326.7 AMD21457.1 - 2.9e-259 862.0 0.0 3.7e-259 861.6 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 AMD21457.1 - 8.4e-176 585.1 0.0 1.1e-175 584.7 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 AMD21457.1 - 7.9e-52 175.6 0.0 1.6e-51 174.6 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 AMD21457.1 - 1.7e-26 92.4 0.1 3.5e-26 91.4 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 AMD21457.1 - 7.7e-21 74.0 0.0 1.3e-19 70.1 0.0 2.8 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 AMD21457.1 - 7.6e-17 60.7 0.0 1.9e-16 59.4 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 AMD21457.1 - 1.1e-12 48.0 0.0 3e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 AMD21457.1 - 8.8e-10 37.8 0.0 9.7e-08 31.1 0.0 3.1 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 AMD21457.1 - 0.00023 20.6 0.0 0.00061 19.2 0.0 1.7 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 AMD21457.1 - 0.0019 18.1 0.0 0.0073 16.1 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain RnfC_N PF13375.1 AMD21457.1 - 0.024 14.3 0.0 0.096 12.4 0.0 2.0 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Tim17 PF02466.14 AMD21458.1 - 6.9e-27 94.0 2.0 8.8e-27 93.6 1.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Peptidase_S8 PF00082.17 AMD21459.1 - 2.5e-47 161.3 0.2 3.9e-47 160.7 0.2 1.3 1 0 0 1 1 1 1 Subtilase family DUF605 PF04652.11 AMD21459.1 - 3.2 7.0 21.7 4.6 6.5 15.0 1.1 1 0 0 1 1 1 0 Vta1 like Nop14 PF04147.7 AMD21459.1 - 7.8 4.2 35.3 12 3.7 24.5 1.1 1 0 0 1 1 1 0 Nop14-like family HIG_1_N PF04588.8 AMD21460.1 - 1.5e-05 24.6 2.0 3.3e-05 23.5 1.4 1.6 1 1 0 1 1 1 1 Hypoxia induced protein conserved region RapA_C PF12137.3 AMD21460.1 - 0.039 12.7 0.1 0.055 12.2 0.1 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Ribosomal_L19 PF01245.15 AMD21461.1 - 1.4e-10 40.9 0.2 1.9e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 MutS_IV PF05190.13 AMD21461.1 - 0.042 14.0 0.0 0.19 11.9 0.0 2.0 2 0 0 2 2 2 0 MutS family domain IV WBS_methylT PF12589.3 AMD21462.1 - 1.8e-16 60.4 6.0 3.9e-16 59.3 4.2 1.7 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 AMD21462.1 - 3.9e-13 49.7 0.0 9.1e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD21462.1 - 4.4e-07 29.7 0.0 6.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD21462.1 - 5.4e-07 29.9 0.0 1.2e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD21462.1 - 7.5e-07 29.5 0.0 2.9e-06 27.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD21462.1 - 1e-06 28.3 0.0 2.4e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 AMD21462.1 - 1.1e-05 24.6 0.0 6e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 AMD21462.1 - 2.7e-05 24.7 0.0 7.3e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 AMD21462.1 - 0.0016 17.9 0.0 0.0057 16.2 0.0 1.8 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 AMD21462.1 - 0.0017 18.3 0.0 0.006 16.6 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain AdoMet_MTase PF07757.8 AMD21462.1 - 0.005 16.9 0.1 0.013 15.6 0.0 1.7 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase PrmA PF06325.8 AMD21462.1 - 0.011 14.9 0.3 0.031 13.4 0.1 1.7 3 0 0 3 3 3 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.7 AMD21462.1 - 0.025 13.9 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MBOAT PF03062.14 AMD21463.1 - 3.1e-51 174.4 36.6 4e-51 174.0 25.3 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 AMD21463.1 - 0.0065 16.5 5.5 0.023 14.7 3.8 2.0 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Peptidase_M76 PF09768.4 AMD21464.1 - 6.2e-75 250.4 4.3 7.6e-75 250.1 3.0 1.1 1 0 0 1 1 1 1 Peptidase M76 family Tox-MPTase2 PF15638.1 AMD21464.1 - 0.034 13.6 0.1 0.058 12.9 0.1 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 2 NotI PF12183.3 AMD21464.1 - 0.035 13.1 0.1 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease NotI Dicty_spore_N PF04562.7 AMD21464.1 - 0.12 12.5 0.4 0.12 12.5 0.3 2.0 2 1 0 2 2 2 0 Dictyostelium spore coat protein, N terminus SprT-like PF10263.4 AMD21464.1 - 3.2 7.3 6.1 2.5 7.7 0.4 2.3 1 1 0 2 2 2 0 SprT-like family Ank_5 PF13857.1 AMD21465.1 - 3.2e-18 65.3 0.0 2.9e-13 49.5 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 AMD21465.1 - 5.9e-16 58.5 0.2 3.3e-08 33.8 0.3 3.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD21465.1 - 1.9e-12 47.3 0.1 6.3e-11 42.4 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 AMD21465.1 - 9.1e-11 41.0 3.5 5.8e-08 32.1 0.2 3.5 2 1 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 AMD21465.1 - 3.1e-09 36.1 1.1 6.3e-06 25.9 0.1 3.9 4 1 0 4 4 4 2 Ankyrin repeat DUF1682 PF07946.9 AMD21466.1 - 4.5e-77 259.0 6.5 5.3e-77 258.8 4.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Ribosomal_L9_N PF01281.14 AMD21467.1 - 0.0081 15.3 0.0 0.016 14.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain SWIB PF02201.13 AMD21468.1 - 0.013 15.1 0.0 0.031 13.9 0.0 1.8 1 1 0 1 1 1 0 SWIB/MDM2 domain Thr_synth_N PF14821.1 AMD21469.1 - 8.5e-28 96.2 0.0 3.1e-27 94.4 0.0 2.0 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.20 AMD21469.1 - 1e-17 64.3 0.0 1.7e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Atx10homo_assoc PF09759.4 AMD21470.1 - 2.1e-37 126.9 0.6 4.6e-37 125.8 0.4 1.6 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain WD40 PF00400.27 AMD21471.1 - 6.2e-58 190.7 13.4 4.9e-13 48.4 0.1 13.5 14 0 0 14 14 14 7 WD domain, G-beta repeat Utp12 PF04003.7 AMD21471.1 - 3.1e-31 107.5 0.0 5e-31 106.8 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Nbas_N PF15492.1 AMD21471.1 - 0.00049 19.2 1.4 2.6 7.0 0.0 4.6 4 1 1 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.11 AMD21471.1 - 0.00052 18.4 0.8 0.011 14.0 0.0 3.3 4 1 1 5 5 5 1 Cytochrome D1 heme domain NUC153 PF08159.7 AMD21472.1 - 3.6e-12 45.6 5.6 7.7e-12 44.5 3.9 1.6 1 0 0 1 1 1 1 NUC153 domain SEEEED PF14797.1 AMD21472.1 - 1.6 8.8 23.4 0.35 11.0 12.5 2.3 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex SNARE PF05739.14 AMD21473.1 - 0.005 16.5 1.8 0.005 16.5 1.2 3.5 4 1 0 4 4 4 1 SNARE domain DUF3153 PF11353.3 AMD21473.1 - 8.8 5.7 7.9 34 3.7 5.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3153) Ecl1 PF12855.2 AMD21474.1 - 6.6e-15 54.1 2.6 6.6e-15 54.1 1.8 1.7 2 0 0 2 2 2 1 Life-span regulatory factor zf-MYND PF01753.13 AMD21474.1 - 0.048 13.5 0.9 0.11 12.4 0.6 1.6 1 0 0 1 1 1 0 MYND finger DUF581 PF04570.9 AMD21474.1 - 0.07 12.4 3.7 0.33 10.2 2.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF581) DUF2116 PF09889.4 AMD21474.1 - 0.32 10.8 1.5 0.6 9.9 1.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF2256 PF10013.4 AMD21474.1 - 0.41 10.4 2.8 0.43 10.3 0.3 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2 PF00096.21 AMD21475.1 - 6.4e-09 35.6 11.7 0.00026 21.1 1.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD21475.1 - 9.7e-09 35.1 12.2 1.4e-05 25.0 1.6 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 AMD21475.1 - 1.1e-06 28.4 10.1 0.0025 18.0 0.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.1 AMD21475.1 - 0.03 13.9 4.7 1.6 8.4 0.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.1 AMD21475.1 - 0.053 13.4 4.6 1.9 8.4 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AMD21475.1 - 0.062 13.4 2.1 0.68 10.1 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding SPRR2 PF14820.1 AMD21475.1 - 1 9.3 0.0 1 9.3 0.0 3.3 3 0 0 3 3 3 0 Small proline-rich 2 Vezatin PF12632.2 AMD21476.1 - 0.13 11.2 2.8 0.23 10.5 0.1 2.0 2 0 0 2 2 2 0 Mysoin-binding motif of peroxisomes DUF1279 PF06916.8 AMD21478.1 - 3.2e-25 88.2 0.0 4.6e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) DUF2132 PF09905.4 AMD21478.1 - 0.1 12.5 0.1 1.4 8.9 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2132) Ribosomal_L24e PF01246.15 AMD21480.1 - 2.3e-33 113.8 0.2 2.3e-33 113.8 0.1 2.1 2 1 0 2 2 2 1 Ribosomal protein L24e PVL_ORF50 PF07768.6 AMD21480.1 - 0.26 11.2 9.2 0.34 10.9 6.4 1.3 1 0 0 1 1 1 0 PVL ORF-50-like family RR_TM4-6 PF06459.7 AMD21480.1 - 2.8 7.7 7.3 3.4 7.4 5.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L7Ae PF01248.21 AMD21481.1 - 2e-24 84.8 0.1 2.3e-24 84.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF2838 PF10998.3 AMD21482.1 - 2.8e-40 136.6 15.3 2.8e-40 136.6 10.6 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) PPR_2 PF13041.1 AMD21483.1 - 1.7e-19 69.5 2.6 1.2e-13 50.7 0.2 4.0 3 1 1 4 4 4 2 PPR repeat family PPR_1 PF12854.2 AMD21483.1 - 6.5e-14 51.1 0.1 1.9e-07 30.3 0.0 3.7 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.1 AMD21483.1 - 3.2e-09 36.3 7.4 0.0034 17.5 0.0 6.5 7 0 0 7 7 7 2 Pentatricopeptide repeat domain PPR PF01535.15 AMD21483.1 - 1e-08 34.5 0.3 1.2e-06 28.0 0.0 4.7 7 0 0 7 7 7 2 PPR repeat TPR_7 PF13176.1 AMD21483.1 - 0.048 13.4 0.0 0.33 10.8 0.0 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Cgr1 PF03879.9 AMD21484.1 - 1.5e-36 124.8 30.6 1.5e-36 124.8 21.2 1.4 1 1 1 2 2 2 1 Cgr1 family ASXH PF13919.1 AMD21484.1 - 0.13 12.1 12.0 0.38 10.5 8.3 1.9 1 1 0 1 1 1 0 Asx homology domain DRY_EERY PF09750.4 AMD21484.1 - 0.67 10.0 8.2 0.94 9.5 5.7 1.3 1 0 0 1 1 1 0 Alternative splicing regulator Trypan_glycop PF00913.14 AMD21484.1 - 1.7 7.4 8.8 2.4 6.9 6.1 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Atg14 PF10186.4 AMD21484.1 - 4.2 6.2 14.4 4 6.2 9.9 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 AMD21484.1 - 4.3 5.6 10.4 4 5.7 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.7 AMD21484.1 - 5.3 5.9 14.1 5.8 5.8 9.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 AMD21484.1 - 5.5 6.5 9.8 6.2 6.3 6.8 1.2 1 0 0 1 1 1 0 IncA protein DUF706 PF05153.10 AMD21485.1 - 7.2e-121 402.2 7.1 9.1e-121 401.9 4.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF706) HD PF01966.17 AMD21485.1 - 0.0053 16.7 1.4 0.68 9.9 0.0 2.6 1 1 1 2 2 2 2 HD domain Glyco_hydro_63 PF03200.11 AMD21486.1 - 1.7e-211 704.2 3.6 9e-211 701.8 2.5 1.8 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase GDE_C PF06202.9 AMD21486.1 - 0.00073 18.3 0.2 0.0017 17.1 0.0 1.7 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase Trehalase PF01204.13 AMD21486.1 - 0.012 14.2 0.3 0.023 13.3 0.2 1.4 1 1 0 1 1 1 0 Trehalase Rrn6 PF10214.4 AMD21487.1 - 2.8e-127 425.8 18.5 4.4e-127 425.2 12.8 1.3 1 1 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Trp_syntA PF00290.15 AMD21488.1 - 6.5e-91 303.4 0.1 1.2e-90 302.5 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 AMD21488.1 - 1.4e-44 152.5 1.0 2.4e-44 151.7 0.7 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Med3 PF11593.3 AMD21489.1 - 2.2e-54 185.1 5.0 3.6e-44 151.5 0.2 2.9 1 1 1 2 2 2 2 Mediator complex subunit 3 fungal Utp14 PF04615.8 AMD21491.1 - 2.5e-202 673.9 75.5 2.5e-202 673.9 52.3 2.0 1 1 1 2 2 2 1 Utp14 protein TcdB_toxin_midC PF12255.3 AMD21491.1 - 0.11 12.1 4.7 0.043 13.4 0.4 2.4 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/C-terminal region Proteasome PF00227.21 AMD21492.1 - 1.1e-58 197.7 0.0 1.4e-58 197.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 AMD21492.1 - 4.3e-09 35.5 0.7 8e-09 34.6 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature zf-CCCH PF00642.19 AMD21493.1 - 1.5e-07 30.9 6.6 2.8e-05 23.6 1.4 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 AMD21493.1 - 1.3e-05 24.9 0.0 2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD21493.1 - 0.00059 19.4 0.0 0.00089 18.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21493.1 - 0.057 13.4 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) 3H PF02829.9 AMD21493.1 - 0.11 12.5 0.1 0.22 11.5 0.0 1.5 1 1 0 1 1 1 0 3H domain LRV_FeS PF05484.6 AMD21493.1 - 0.15 11.7 2.8 3.2 7.3 0.2 2.6 2 0 0 2 2 2 0 LRV protein FeS4 cluster zf-CCCH_2 PF14608.1 AMD21493.1 - 2.1 8.4 9.8 7.4 6.7 0.8 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type Rtf2 PF04641.7 AMD21494.1 - 8e-37 126.8 0.0 1.7e-36 125.7 0.0 1.4 1 1 0 1 1 1 1 Rtf2 RING-finger COX14 PF14880.1 AMD21495.1 - 3.6e-22 77.7 1.1 3.9e-22 77.6 0.8 1.0 1 0 0 1 1 1 1 Cytochrome oxidase c assembly Bac_rhamnosid_N PF08531.5 AMD21495.1 - 0.012 15.1 0.1 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 Alpha-L-rhamnosidase N-terminal domain Ish1 PF10281.4 AMD21496.1 - 2.9e-32 110.3 37.4 3.1e-09 36.7 1.7 6.4 6 0 0 6 6 6 5 Putative stress-responsive nuclear envelope protein HeH PF12949.2 AMD21496.1 - 1.1e-07 31.3 7.8 0.0049 16.3 0.3 5.1 5 0 0 5 5 5 3 HeH/LEM domain DUF883 PF05957.8 AMD21496.1 - 1.6e-07 31.6 6.8 0.15 12.4 0.7 5.1 2 1 3 5 5 5 3 Bacterial protein of unknown function (DUF883) Slx4 PF09494.5 AMD21496.1 - 0.052 13.2 1.6 5.3 6.8 0.0 3.5 5 0 0 5 5 5 0 Slx4 endonuclease SAM_2 PF07647.12 AMD21496.1 - 0.33 10.8 3.5 19 5.2 0.0 4.5 5 0 0 5 5 5 0 SAM domain (Sterile alpha motif) DUF3708 PF12501.3 AMD21496.1 - 0.34 10.7 0.5 1.1e+02 2.5 0.0 3.4 1 1 2 3 3 3 0 Phosphate ATP-binding cassette transporter RPM2 PF08579.6 AMD21498.1 - 4.3e-39 133.3 0.4 3.4e-38 130.4 0.1 2.8 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.1 AMD21498.1 - 0.00095 19.1 2.9 0.42 10.6 0.0 5.8 8 0 0 8 8 8 1 PPR repeat family HMG_CoA_synt_C PF08540.5 AMD21499.1 - 8.2e-107 356.8 1.2 1e-106 356.5 0.8 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 AMD21499.1 - 4.9e-94 312.7 0.1 7.5e-94 312.1 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Mus7 PF09462.5 AMD21500.1 - 6.3e-35 121.1 22.1 6.6e-22 78.0 4.8 2.7 1 1 1 2 2 2 2 Mus7/MMS22 family AIP3 PF03915.8 AMD21501.1 - 3.1e-147 490.8 16.7 3.1e-147 490.8 11.6 2.3 2 1 0 2 2 2 1 Actin interacting protein 3 HRDC PF00570.18 AMD21501.1 - 0.033 13.9 0.1 2 8.2 0.0 2.7 2 0 0 2 2 2 0 HRDC domain FliL PF03748.9 AMD21501.1 - 0.046 13.7 3.7 0.051 13.5 0.0 3.0 3 0 0 3 3 3 0 Flagellar basal body-associated protein FliL HSBP1 PF06825.7 AMD21501.1 - 0.078 12.5 1.2 0.16 11.5 0.0 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Telomerase_RBD PF12009.3 AMD21502.1 - 2.8e-28 98.5 0.5 2.8e-28 98.5 0.3 2.2 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 AMD21502.1 - 1.2e-10 41.1 2.4 4.8e-10 39.1 1.5 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) dCMP_cyt_deam_1 PF00383.17 AMD21503.1 - 4.7e-07 29.3 0.2 7.7e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF3635 PF12330.3 AMD21504.1 - 3.8e-10 39.6 0.2 3.8e-10 39.6 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3635) Pkinase PF00069.20 AMD21504.1 - 6.3e-05 22.2 0.0 0.00018 20.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21504.1 - 0.00032 19.8 0.0 0.00088 18.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase STT3 PF02516.9 AMD21505.1 - 8e-133 443.9 44.0 5.8e-130 434.4 29.5 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit FYVE PF01363.16 AMD21506.1 - 2.1e-15 56.3 5.7 5.3e-15 55.0 3.9 1.7 1 0 0 1 1 1 1 FYVE zinc finger Acyltransferase PF01553.16 AMD21507.1 - 6e-10 38.6 0.0 3.8e-09 36.0 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase Formyl_trans_N PF00551.14 AMD21508.1 - 3.9e-26 91.7 0.0 5.8e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.13 AMD21508.1 - 0.00018 21.5 0.0 0.00031 20.7 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Prefoldin PF02996.12 AMD21509.1 - 2e-28 98.4 1.9 2.9e-28 97.9 1.3 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.1 AMD21509.1 - 0.0016 18.1 0.8 0.0038 16.9 0.2 1.7 1 1 1 2 2 2 1 Prefoldin subunit Omptin PF01278.15 AMD21509.1 - 0.0042 16.2 0.5 0.0058 15.7 0.3 1.1 1 0 0 1 1 1 1 Omptin family DLD PF14878.1 AMD21509.1 - 0.023 14.8 0.3 0.046 13.8 0.0 1.6 2 0 0 2 2 2 0 Death-like domain of SPT6 DUF2110 PF09883.4 AMD21509.1 - 0.066 12.8 0.1 0.075 12.6 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) Prefoldin_2 PF01920.15 AMD21509.1 - 0.36 10.5 8.4 1.7 8.4 0.3 2.3 2 0 0 2 2 2 0 Prefoldin subunit H-kinase_dim PF02895.9 AMD21509.1 - 0.52 10.6 2.4 2.9 8.3 0.6 2.2 2 0 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Sec20 PF03908.8 AMD21509.1 - 0.54 9.9 4.3 1.6 8.5 0.4 2.4 2 0 0 2 2 2 0 Sec20 Fib_alpha PF08702.5 AMD21509.1 - 0.89 9.6 4.6 3.2 7.8 0.2 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4200 PF13863.1 AMD21509.1 - 1 9.3 10.3 0.94 9.4 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) YlqD PF11068.3 AMD21509.1 - 2.9 7.9 12.0 0.71 9.9 2.0 2.2 2 0 0 2 2 2 0 YlqD protein FliJ PF02050.11 AMD21509.1 - 8.5 6.4 15.9 5.1 7.1 2.6 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein Rad10 PF03834.9 AMD21510.1 - 4.6e-26 90.2 0.1 8.1e-26 89.5 0.0 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Asn_synthase PF00733.16 AMD21511.1 - 3.6e-46 157.7 0.0 5.4e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 AMD21511.1 - 6.3e-11 42.0 0.1 3.4e-09 36.4 0.1 2.6 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 AMD21511.1 - 8.7e-06 25.7 0.0 2.5e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 AMD21511.1 - 0.028 13.6 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Aluminium induced protein DUF3252 PF11623.3 AMD21511.1 - 0.066 12.6 0.0 0.18 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3252) VPS9 PF02204.13 AMD21512.1 - 7.5e-29 99.8 0.1 1.6e-28 98.7 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 AMD21512.1 - 1.6e-11 43.4 0.0 4e-10 38.9 0.0 2.7 2 0 0 2 2 2 1 CUE domain ERO1 PF04137.10 AMD21513.1 - 2.3e-120 401.9 0.2 3.9e-120 401.1 0.1 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Muted PF14942.1 AMD21513.1 - 0.015 15.1 0.5 0.029 14.2 0.3 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein TFIID-18kDa PF02269.11 AMD21514.1 - 2.9e-31 107.1 0.0 4.3e-31 106.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.19 AMD21514.1 - 8.5e-05 22.5 0.1 0.00059 19.9 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 AMD21514.1 - 0.0036 17.2 0.3 0.025 14.5 0.0 2.1 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Aerolysin PF01117.15 AMD21514.1 - 0.021 13.7 0.1 0.026 13.4 0.0 1.1 1 0 0 1 1 1 0 Aerolysin toxin GLTSCR1 PF15249.1 AMD21514.1 - 0.074 13.1 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Glioma tumor suppressor candidate region Fungal_trans_2 PF11951.3 AMD21515.1 - 2e-76 257.0 4.8 3e-76 256.5 3.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD21515.1 - 9.3e-12 44.6 7.6 2.2e-11 43.4 5.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vac14_Fig4_bd PF11916.3 AMD21515.1 - 0.0017 17.5 1.5 0.0017 17.5 1.1 1.9 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding 6PF2K PF01591.13 AMD21516.1 - 1.2e-79 266.5 1.4 6.3e-79 264.1 0.1 2.1 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 AMD21516.1 - 6.7e-30 104.2 0.0 7.7e-29 100.8 0.0 2.4 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 AMD21516.1 - 5.4e-08 32.8 0.0 1.1e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD21516.1 - 6.2e-07 30.2 0.1 3.4e-06 27.8 0.0 2.5 2 2 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 AMD21516.1 - 0.00014 21.0 0.0 0.00026 20.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin MMR_HSR1 PF01926.18 AMD21516.1 - 0.0025 17.7 0.1 0.024 14.6 0.0 2.5 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_18 PF13238.1 AMD21516.1 - 0.0068 16.7 0.2 0.037 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 AMD21516.1 - 0.014 14.6 0.0 0.034 13.3 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Pox_A28 PF04584.9 AMD21516.1 - 0.083 12.7 1.3 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 Poxvirus A28 family Metallopep PF12044.3 AMD21517.1 - 2.3e-165 550.1 0.0 3.6e-165 549.5 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.12 AMD21517.1 - 3.5e-07 30.1 0.3 0.011 15.5 0.0 2.6 1 1 1 2 2 2 2 Jacalin-like lectin domain Reprolysin_5 PF13688.1 AMD21517.1 - 0.0073 16.2 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 AMD21517.1 - 0.039 14.4 0.0 0.082 13.4 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 AMD21517.1 - 0.18 11.8 0.2 0.35 10.8 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.19 AMD21517.1 - 0.21 10.9 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Sec23_trunk PF04811.10 AMD21518.1 - 1.5e-70 237.3 0.0 4.3e-70 235.8 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 AMD21518.1 - 1.3e-26 92.0 0.0 3.7e-26 90.5 0.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 AMD21518.1 - 1.8e-18 65.7 7.7 3.4e-18 64.9 5.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 AMD21518.1 - 7.8e-17 61.5 2.8 1.8e-16 60.3 0.1 2.9 4 0 0 4 4 4 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 AMD21518.1 - 3.7e-10 39.3 0.0 8.6e-10 38.1 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat DUF2011 PF09428.5 AMD21519.1 - 1.1e-26 93.2 19.2 1.6e-26 92.7 13.3 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Glyco_hydro_65C PF03633.10 AMD21519.1 - 0.029 14.4 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain COG5 PF10392.4 AMD21520.1 - 1.4e-37 128.6 3.3 1.4e-37 128.6 2.3 3.1 4 0 0 4 4 4 1 Golgi transport complex subunit 5 DUF733 PF05306.6 AMD21520.1 - 3.2 8.1 7.6 0.27 11.5 0.5 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF733) Methyltransf_16 PF10294.4 AMD21521.1 - 0.0091 15.4 0.9 2.6 7.4 0.0 2.3 1 1 1 2 2 2 2 Putative methyltransferase COX4 PF02936.9 AMD21522.1 - 4e-39 133.6 0.4 4.4e-39 133.4 0.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Ank_2 PF12796.2 AMD21523.1 - 2.1e-58 194.6 0.5 1.4e-23 83.0 0.1 3.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 AMD21523.1 - 3.7e-39 130.5 1.3 4.5e-11 41.9 0.2 6.1 5 1 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 AMD21523.1 - 8.4e-31 105.3 0.2 5.2e-08 32.8 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 AMD21523.1 - 1.1e-28 96.3 0.0 1.3e-07 31.2 0.2 6.3 5 1 1 6 6 6 4 Ankyrin repeat Ank_4 PF13637.1 AMD21523.1 - 4.3e-27 93.9 0.0 1.2e-11 44.7 0.0 4.9 3 1 1 4 4 4 4 Ankyrin repeats (many copies) DSPc PF00782.15 AMD21524.1 - 5.9e-35 119.7 0.2 1.3e-34 118.6 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 AMD21524.1 - 0.00012 21.5 0.1 0.00021 20.7 0.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 AMD21524.1 - 0.031 13.7 0.1 0.072 12.5 0.1 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 AMD21524.1 - 0.043 13.8 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Serglycin PF04360.7 AMD21524.1 - 0.051 13.2 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Serglycin Vac7 PF12751.2 AMD21525.1 - 7.4e-20 71.1 29.2 5.4e-12 45.2 10.1 3.6 2 1 1 3 3 3 2 Vacuolar segregation subunit 7 Porin_3 PF01459.17 AMD21526.1 - 4.5e-63 213.1 0.2 5e-63 212.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin Aminotran_1_2 PF00155.16 AMD21528.1 - 5.8e-62 209.7 0.0 7.1e-62 209.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 AMD21528.1 - 0.02 13.1 0.0 0.041 12.1 0.0 1.6 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.8 AMD21528.1 - 0.058 12.0 0.0 0.077 11.6 0.0 1.2 1 0 0 1 1 1 0 Allinase Med5 PF08689.5 AMD21528.1 - 0.097 10.3 0.1 0.12 9.9 0.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit Med5 Y_phosphatase2 PF03162.8 AMD21529.1 - 8.6e-54 181.3 0.0 1e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 AMD21529.1 - 1.3e-05 25.5 0.0 2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 AMD21529.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PMP1_2 PF08114.6 AMD21530.1 - 0.034 13.6 0.3 0.071 12.6 0.2 1.5 1 0 0 1 1 1 0 ATPase proteolipid family Herpes_gE PF02480.11 AMD21530.1 - 0.04 12.1 0.0 0.057 11.6 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Ras PF00071.17 AMD21531.1 - 7.8e-56 187.9 0.0 9.8e-56 187.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD21531.1 - 2e-16 60.5 0.0 2.9e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD21531.1 - 2.4e-09 36.6 0.0 5.6e-09 35.4 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 AMD21531.1 - 0.00087 18.5 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 AMD21531.1 - 0.0012 18.0 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 AMD21531.1 - 0.0019 18.1 0.0 0.0026 17.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arch_ATPase PF01637.13 AMD21531.1 - 0.023 14.3 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase ABC_tran PF00005.22 AMD21531.1 - 0.049 13.9 0.0 0.084 13.1 0.0 1.5 2 0 0 2 2 2 0 ABC transporter G-alpha PF00503.15 AMD21531.1 - 0.05 12.2 0.0 0.053 12.2 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Actin PF00022.14 AMD21532.1 - 1.4e-48 165.2 0.1 3.9e-29 101.2 0.0 2.2 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.8 AMD21532.1 - 0.014 14.0 0.0 0.16 10.5 0.0 2.4 3 0 0 3 3 3 0 MreB/Mbl protein DUF3040 PF11239.3 AMD21532.1 - 0.17 11.9 0.4 0.44 10.6 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Nol1_Nop2_Fmu PF01189.12 AMD21533.1 - 5.7e-108 360.5 0.0 8.6e-108 360.0 0.0 1.3 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_31 PF13847.1 AMD21533.1 - 0.002 17.7 0.0 0.004 16.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 AMD21533.1 - 0.002 18.1 0.0 0.0049 16.8 0.0 1.8 1 0 0 1 1 1 1 FtsJ-like methyltransferase Bradykinin PF06753.7 AMD21533.1 - 0.22 11.0 0.8 0.52 9.8 0.5 1.6 1 0 0 1 1 1 0 Bradykinin Gcd10p PF04189.8 AMD21534.1 - 1.6e-97 326.2 0.1 1.9e-97 325.9 0.1 1.1 1 0 0 1 1 1 1 Gcd10p family Methyltransf_26 PF13659.1 AMD21535.1 - 2.1e-13 50.3 0.0 5.7e-13 48.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 AMD21535.1 - 7.3e-11 41.7 0.0 1.1e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 AMD21535.1 - 7.7e-11 41.8 0.0 1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD21535.1 - 5.6e-10 39.7 0.0 8.9e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD21535.1 - 5.1e-08 33.1 0.0 8.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 AMD21535.1 - 0.00048 19.5 0.0 0.00071 19.0 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.13 AMD21535.1 - 0.0012 18.4 0.0 0.023 14.2 0.0 2.6 3 0 0 3 3 3 1 Putative RNA methylase family UPF0020 Methyltransf_10 PF05971.7 AMD21535.1 - 0.0016 17.6 0.0 0.0023 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF890) PrmA PF06325.8 AMD21535.1 - 0.0032 16.6 0.0 0.0044 16.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 AMD21535.1 - 0.0038 17.6 0.0 0.0067 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD21535.1 - 0.0053 16.5 0.0 0.0088 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD21535.1 - 0.011 16.1 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DnaJ PF00226.26 AMD21536.1 - 1.7e-26 91.7 3.1 2.8e-26 91.0 2.1 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 AMD21536.1 - 1.3e-19 69.9 0.6 1.1e-16 60.4 0.0 2.5 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 AMD21536.1 - 3e-13 49.6 16.2 3e-13 49.6 11.2 1.6 2 0 0 2 2 2 1 DnaJ central domain HypA PF01155.14 AMD21536.1 - 0.059 13.0 9.1 0.46 10.1 1.3 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Y_phosphatase2 PF03162.8 AMD21538.1 - 7.7e-56 187.9 0.0 9.2e-56 187.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 AMD21538.1 - 5.5e-06 26.7 0.0 5.6e-05 23.4 0.0 2.0 1 1 1 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 AMD21538.1 - 0.14 11.7 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DAD PF02109.11 AMD21539.1 - 2.5e-38 130.6 3.1 2.9e-38 130.3 2.2 1.1 1 0 0 1 1 1 1 DAD family Ras PF00071.17 AMD21540.1 - 2.2e-54 183.1 0.1 2.8e-54 182.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD21540.1 - 2.8e-20 72.9 0.0 4.5e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD21540.1 - 1.6e-09 37.2 0.0 1.9e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD21540.1 - 1.8e-05 24.2 0.1 6.4e-05 22.4 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD21540.1 - 0.00037 20.4 0.0 0.00055 19.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 AMD21540.1 - 0.032 13.3 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_25 PF13481.1 AMD21540.1 - 0.052 12.9 0.0 0.08 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 AMD21540.1 - 0.13 12.0 0.3 0.57 9.9 0.0 2.3 2 1 0 2 2 2 0 Part of AAA domain Neuromodulin PF06614.6 AMD21540.1 - 0.38 10.6 6.7 0.55 10.1 4.6 1.2 1 0 0 1 1 1 0 Neuromodulin ING PF12998.2 AMD21541.1 - 4.6e-17 62.2 2.4 7.2e-17 61.5 0.1 2.1 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 AMD21541.1 - 1.8e-08 33.9 8.5 3.3e-08 33.0 5.9 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 AMD21541.1 - 0.0075 16.3 1.0 0.018 15.1 0.7 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain PMT_C PF11647.3 AMD21541.1 - 0.015 14.9 0.2 0.55 9.8 0.0 2.5 2 0 0 2 2 2 0 C-terminal region of Pasteurella multocida toxin residues 569-1285 PHD_2 PF13831.1 AMD21541.1 - 0.17 11.2 2.1 0.37 10.1 1.5 1.5 1 0 0 1 1 1 0 PHD-finger 5_nucleotid PF05761.9 AMD21541.1 - 2 6.8 4.1 2.8 6.3 2.7 1.4 1 1 0 1 1 1 0 5' nucleotidase family zf-RING-like PF08746.6 AMD21541.1 - 2.1 8.4 5.3 4.3 7.4 3.7 1.6 1 0 0 1 1 1 0 RING-like domain Mito_carr PF00153.22 AMD21542.1 - 9.7e-55 182.2 8.9 1.5e-19 69.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_15 PF01793.11 AMD21543.1 - 3.1e-141 470.1 13.3 3.7e-141 469.8 9.2 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase SHIPPO-rpt PF07004.7 AMD21544.1 - 5.7 8.0 28.5 3.7 8.6 0.3 8.9 5 1 1 6 6 6 0 Sperm-tail PG-rich repeat Ribosomal_S7e PF01251.13 AMD21545.1 - 5.6e-82 273.8 3.5 6.6e-82 273.5 2.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Rib_5-P_isom_A PF06026.9 AMD21546.1 - 1.2e-55 187.5 0.0 1.5e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 AMD21546.1 - 5.5e-05 22.8 0.0 0.0036 16.9 0.0 2.2 1 1 0 1 1 1 1 DeoR C terminal sensor domain Sugar-bind PF04198.8 AMD21546.1 - 0.058 12.2 0.0 0.086 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain Arf PF00025.16 AMD21547.1 - 3.6e-71 237.9 0.1 4.1e-71 237.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 AMD21547.1 - 1.6e-13 50.3 0.0 2e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 AMD21547.1 - 5.6e-13 48.3 0.7 1.1e-08 34.1 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 AMD21547.1 - 9.5e-13 47.7 0.0 1.2e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 AMD21547.1 - 4.5e-11 42.3 0.0 5.2e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 AMD21547.1 - 1.1e-09 38.8 0.0 1.5e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 AMD21547.1 - 5.1e-06 26.4 0.0 6.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AMP-binding PF00501.23 AMD21548.1 - 1.2e-32 112.8 0.0 1.4e-10 40.1 0.0 5.1 5 0 0 5 5 5 5 AMP-binding enzyme DMAP_binding PF06464.6 AMD21548.1 - 1.6e-05 25.4 0.2 3.8e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 DMAP1-binding Domain Mem_trans PF03547.13 AMD21549.1 - 4.3e-74 249.1 0.0 1.7e-73 247.1 0.0 1.7 1 1 0 1 1 1 1 Membrane transport protein DUF2183 PF09949.4 AMD21550.1 - 2.6e-31 107.5 0.0 1.1e-30 105.4 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) zf-CCCH PF00642.19 AMD21551.1 - 2.4e-06 27.0 3.6 6.1e-06 25.7 0.2 2.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PP2C PF00481.16 AMD21552.1 - 3.3e-37 128.2 0.0 5.5e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Ras PF00071.17 AMD21553.1 - 1.8e-59 199.7 0.0 2.1e-59 199.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD21553.1 - 4.4e-21 75.5 0.0 6.7e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD21553.1 - 2.9e-17 62.4 0.0 3.2e-17 62.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 AMD21553.1 - 7.5e-08 31.8 0.0 9.2e-08 31.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 AMD21553.1 - 9e-06 25.2 0.0 1.6e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD21553.1 - 5.2e-05 23.1 0.0 7.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase N2227 PF07942.7 AMD21554.1 - 4.4e-95 317.7 0.1 5.6e-95 317.3 0.1 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 AMD21554.1 - 0.00067 19.4 0.0 0.0023 17.6 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD21554.1 - 0.0052 17.2 0.0 0.014 15.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD21554.1 - 0.0097 16.3 0.0 0.024 15.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 AMD21554.1 - 0.041 13.5 0.0 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase NST1 PF13945.1 AMD21555.1 - 2.9e-09 37.2 14.5 2.9e-09 37.2 10.0 5.4 3 2 1 4 4 4 1 Salt tolerance down-regulator Fe-ADH PF00465.14 AMD21555.1 - 0.03 12.9 0.0 0.069 11.7 0.0 1.5 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Ras PF00071.17 AMD21556.1 - 5.3e-50 168.9 0.0 6.2e-50 168.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD21556.1 - 1.3e-15 57.9 0.0 1.7e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD21556.1 - 2e-09 36.9 0.0 2.7e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.4 AMD21556.1 - 2.2e-05 23.9 0.1 0.00081 18.9 0.1 2.3 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.22 AMD21556.1 - 0.0016 17.9 0.0 0.024 14.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 AMD21556.1 - 0.025 13.7 0.0 0.035 13.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 AMD21556.1 - 0.1 11.7 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 AMD21556.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.1 AMD21556.1 - 0.11 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain RRM_6 PF14259.1 AMD21557.1 - 1.1e-06 28.5 0.1 1.6e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD21557.1 - 1.8e-06 27.4 0.1 3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.3 AMD21557.1 - 0.00024 20.3 0.1 0.0004 19.6 0.1 1.3 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Limkain-b1 PF11608.3 AMD21557.1 - 0.00065 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Limkain b1 RRM_5 PF13893.1 AMD21557.1 - 0.0045 16.8 0.0 0.0074 16.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 AMD21557.1 - 0.0055 17.1 0.9 0.0055 17.1 0.6 2.1 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 PUL PF08324.6 AMD21558.1 - 3.1e-51 173.7 2.3 4.6e-51 173.1 1.6 1.3 1 0 0 1 1 1 1 PUL domain PFU PF09070.6 AMD21558.1 - 1.1e-43 147.9 0.7 2.2e-43 146.9 0.5 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 AMD21558.1 - 1e-38 129.8 19.6 3.1e-10 39.5 0.1 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat Syja_N PF02383.13 AMD21559.1 - 5.7e-88 294.7 1.9 8.9e-88 294.0 1.3 1.3 1 0 0 1 1 1 1 SacI homology domain IGPS PF00218.16 AMD21560.1 - 5.9e-88 294.1 0.0 1.5e-87 292.8 0.0 1.7 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase GATase PF00117.23 AMD21560.1 - 1.1e-51 175.0 0.1 1.7e-51 174.4 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AMD21560.1 - 3.3e-09 36.5 0.1 4.2e-08 32.9 0.1 2.4 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.14 AMD21560.1 - 0.0012 18.4 0.1 0.0026 17.3 0.0 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain LuxE PF04443.7 AMD21560.1 - 0.012 14.3 0.0 0.018 13.7 0.0 1.2 1 0 0 1 1 1 0 Acyl-protein synthetase, LuxE TPD52 PF04201.10 AMD21560.1 - 0.1 12.2 0.1 0.26 10.9 0.1 1.6 2 0 0 2 2 2 0 Tumour protein D52 family FMN_dh PF01070.13 AMD21560.1 - 0.11 11.3 0.0 9 5.0 0.0 2.2 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Antimicrobial10 PF08105.6 AMD21560.1 - 0.11 12.1 0.0 0.3 10.7 0.0 1.8 1 0 0 1 1 1 0 Metchnikowin family Septin PF00735.13 AMD21561.1 - 2.4e-108 361.4 0.2 4e-108 360.6 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 AMD21561.1 - 1.6e-07 31.2 0.0 4e-07 30.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 AMD21561.1 - 1.8e-05 24.5 8.1 0.01 15.6 0.1 3.0 2 1 1 3 3 3 2 Dynamin family ABC_tran PF00005.22 AMD21561.1 - 4.4e-05 23.7 1.5 7.1e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.11 AMD21561.1 - 4.9e-05 22.5 0.9 0.00033 19.8 0.6 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 AMD21561.1 - 0.00029 20.0 0.0 0.00029 20.0 0.0 2.0 2 0 0 2 2 2 1 AIG1 family Miro PF08477.8 AMD21561.1 - 0.0026 18.2 0.3 0.012 16.1 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein IIGP PF05049.8 AMD21561.1 - 0.0053 15.6 0.0 0.011 14.5 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_10 PF12846.2 AMD21561.1 - 0.018 14.4 0.3 0.029 13.8 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain Gasdermin PF04598.7 AMD21561.1 - 0.021 13.5 3.9 0.023 13.4 1.4 1.8 2 0 0 2 2 2 0 Gasdermin family AAA_29 PF13555.1 AMD21561.1 - 0.051 13.1 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.9 AMD21561.1 - 0.065 12.9 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 AMD21561.1 - 0.076 13.1 0.1 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 AMD21561.1 - 0.13 11.6 0.0 0.13 11.6 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family G-alpha PF00503.15 AMD21561.1 - 0.14 10.8 4.7 0.16 10.6 0.1 2.7 3 0 0 3 3 3 0 G-protein alpha subunit PduV-EutP PF10662.4 AMD21561.1 - 0.17 11.3 1.4 2.4 7.6 0.1 2.6 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.1 AMD21561.1 - 0.25 11.6 7.2 1.5 9.0 2.3 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 AMD21561.1 - 0.38 10.5 2.8 8.6 6.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 Gly_transf_sug PF04488.10 AMD21562.1 - 4.4e-11 43.0 0.1 1.6e-10 41.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif HSBP1 PF06825.7 AMD21562.1 - 0.025 14.1 1.4 0.068 12.7 1.0 1.7 1 0 0 1 1 1 0 Heat shock factor binding protein 1 IncA PF04156.9 AMD21562.1 - 0.39 10.2 7.6 0.62 9.6 5.3 1.2 1 0 0 1 1 1 0 IncA protein Mog1 PF04603.7 AMD21563.1 - 2e-20 73.1 0.1 7.8e-20 71.2 0.1 1.9 1 1 0 1 1 1 1 Ran-interacting Mog1 protein ThiF PF00899.16 AMD21564.1 - 1.8e-48 163.8 0.4 9.4e-31 106.4 0.0 2.7 3 0 0 3 3 3 2 ThiF family UBA_e1_C PF09358.5 AMD21564.1 - 3.8e-43 146.6 0.1 2e-42 144.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 AMD21564.1 - 5.9e-32 109.0 0.1 8e-23 79.7 0.1 2.9 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 AMD21564.1 - 2.9e-26 90.5 0.4 4.3e-20 70.8 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.1 AMD21564.1 - 0.12 12.6 1.7 1.6 9.0 0.0 3.4 3 1 0 3 3 3 0 Putative NAD(P)-binding ABC_membrane PF00664.18 AMD21565.1 - 7.7e-75 251.8 40.4 1.3e-37 129.6 11.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 AMD21565.1 - 1.1e-59 200.6 0.4 1.5e-30 106.3 0.0 2.9 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.14 AMD21565.1 - 2.6e-18 66.0 3.9 2.6e-07 30.1 0.0 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 AMD21565.1 - 9.4e-09 35.6 20.6 7.1e-05 22.9 0.4 4.9 4 2 0 4 4 2 2 AAA domain AAA_17 PF13207.1 AMD21565.1 - 2.8e-08 34.6 0.3 0.0051 17.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_10 PF12846.2 AMD21565.1 - 5.7e-08 32.5 1.9 0.026 13.9 0.1 3.6 4 0 0 4 4 3 2 AAA-like domain AAA_29 PF13555.1 AMD21565.1 - 9.2e-08 31.5 0.4 0.013 15.0 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.4 AMD21565.1 - 3.8e-07 29.0 0.4 0.019 13.5 0.0 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class DUF258 PF03193.11 AMD21565.1 - 2.1e-06 27.0 0.2 0.017 14.3 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 AMD21565.1 - 6.5e-06 26.3 4.2 0.15 12.1 0.1 4.2 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 AMD21565.1 - 1.3e-05 25.4 0.6 0.1 12.9 0.0 3.2 3 1 0 3 3 2 2 AAA domain DUF87 PF01935.12 AMD21565.1 - 3.3e-05 23.8 0.4 0.022 14.5 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_5 PF07728.9 AMD21565.1 - 4.2e-05 23.2 0.1 0.82 9.3 0.0 4.3 5 0 0 5 5 5 1 AAA domain (dynein-related subfamily) AAA_23 PF13476.1 AMD21565.1 - 0.00011 22.5 0.2 0.08 13.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 AMD21565.1 - 0.0002 20.5 0.0 0.65 9.0 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin MobB PF03205.9 AMD21565.1 - 0.00022 20.9 0.3 0.47 10.1 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 AMD21565.1 - 0.00027 20.9 3.4 0.34 10.8 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.18 AMD21565.1 - 0.00039 20.3 0.0 1.4 8.8 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.1 AMD21565.1 - 0.0008 19.3 0.0 1 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 AMD21565.1 - 0.0012 18.7 0.1 3.5 7.5 0.0 4.4 4 1 0 4 4 3 1 AAA domain AAA_25 PF13481.1 AMD21565.1 - 0.0016 17.8 0.0 0.49 9.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain T2SE PF00437.15 AMD21565.1 - 0.0018 17.1 0.1 0.86 8.4 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein RNA_helicase PF00910.17 AMD21565.1 - 0.0038 17.3 0.9 0.8 9.8 0.0 3.1 3 0 0 3 3 2 1 RNA helicase FtsK_SpoIIIE PF01580.13 AMD21565.1 - 0.0048 16.3 0.0 4.1 6.8 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family APS_kinase PF01583.15 AMD21565.1 - 0.0072 15.9 0.1 3.1 7.4 0.0 2.5 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_13 PF13166.1 AMD21565.1 - 0.012 14.1 0.1 0.13 10.6 0.1 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 AMD21565.1 - 0.014 15.0 7.9 2.5 7.7 0.1 3.9 3 1 1 4 4 4 0 NACHT domain PduV-EutP PF10662.4 AMD21565.1 - 0.02 14.3 0.0 6.6 6.2 0.0 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PRK PF00485.13 AMD21565.1 - 0.022 14.3 0.0 2.5 7.6 0.0 2.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Miro PF08477.8 AMD21565.1 - 0.029 14.8 1.1 3.9 7.9 0.1 2.9 2 0 0 2 2 2 0 Miro-like protein DUF3987 PF13148.1 AMD21565.1 - 0.031 12.8 0.0 4.7 5.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) AAA_24 PF13479.1 AMD21565.1 - 0.034 13.7 0.7 3.2 7.2 0.1 2.9 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 AMD21565.1 - 0.048 13.1 0.0 5.1 6.5 0.0 2.8 3 0 0 3 3 2 0 Sigma-54 interaction domain Dynamin_N PF00350.18 AMD21565.1 - 0.081 12.7 1.8 4.8 6.9 0.1 2.7 2 0 0 2 2 2 0 Dynamin family Arch_ATPase PF01637.13 AMD21565.1 - 0.11 12.2 0.4 0.72 9.5 0.1 2.6 2 1 0 2 2 2 0 Archaeal ATPase SbcCD_C PF13558.1 AMD21565.1 - 0.11 12.4 1.8 0.8 9.6 0.1 3.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.1 AMD21565.1 - 0.12 11.9 0.0 8.2 5.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain Bunya_G2 PF03563.8 AMD21565.1 - 0.16 10.8 3.8 0.44 9.3 0.5 2.4 2 0 0 2 2 2 0 Bunyavirus glycoprotein G2 Peptidase_M13 PF01431.16 AMD21565.1 - 0.27 10.4 0.0 0.54 9.3 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M13 PEMT PF04191.8 AMD21566.1 - 8.2e-33 112.6 2.8 8.2e-33 112.6 2.0 1.7 3 0 0 3 3 3 1 Phospholipid methyltransferase PDR_assoc PF08370.6 AMD21566.1 - 1.3 8.5 6.8 0.29 10.6 0.5 2.5 2 0 0 2 2 2 0 Plant PDR ABC transporter associated DUF4118 PF13493.1 AMD21566.1 - 2.6 8.2 6.4 0.31 11.2 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4118) DUF1237 PF06824.6 AMD21567.1 - 2.1e-172 573.4 0.0 2.5e-172 573.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) DUF106 PF01956.11 AMD21568.1 - 3.2e-53 179.7 1.9 4e-53 179.3 1.3 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF106 ATP_bind_1 PF03029.12 AMD21569.1 - 9.9e-85 283.8 0.3 1.4e-84 283.3 0.2 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 AMD21569.1 - 6.9e-09 35.4 0.9 1.2e-07 31.3 0.6 2.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CbiA PF01656.18 AMD21569.1 - 2.4e-05 23.8 0.1 5.2e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.1 AMD21569.1 - 4.5e-05 23.6 0.1 0.00072 19.7 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.1 AMD21569.1 - 0.0002 21.2 0.0 0.00045 20.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD21569.1 - 0.00022 22.0 2.7 0.00069 20.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 AMD21569.1 - 0.00022 20.7 0.5 0.0051 16.2 0.2 2.3 1 1 0 1 1 1 1 AAA-like domain FeoB_N PF02421.13 AMD21569.1 - 0.00042 19.6 0.1 0.012 14.9 0.0 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B MMR_HSR1 PF01926.18 AMD21569.1 - 0.00075 19.4 0.0 0.0032 17.4 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.7 AMD21569.1 - 0.0013 18.4 0.0 0.0035 17.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain ArgK PF03308.11 AMD21569.1 - 0.0019 17.0 0.1 1.1 7.9 0.0 2.3 2 0 0 2 2 2 2 ArgK protein DUF2365 PF10157.4 AMD21569.1 - 0.0022 17.8 0.2 0.006 16.4 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2365) PduV-EutP PF10662.4 AMD21569.1 - 0.0036 16.8 0.2 0.077 12.4 0.0 2.6 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 AMD21569.1 - 0.0039 16.8 0.3 0.023 14.2 0.0 2.3 3 0 0 3 3 3 1 AAA domain Miro PF08477.8 AMD21569.1 - 0.017 15.6 0.1 0.89 10.0 0.1 2.6 1 1 0 1 1 1 0 Miro-like protein DUF258 PF03193.11 AMD21569.1 - 0.023 13.8 0.1 1.3 8.2 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 AMD21569.1 - 0.025 14.5 0.0 0.069 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 AMD21569.1 - 0.025 14.8 0.8 0.087 13.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.17 AMD21569.1 - 0.027 13.9 0.0 0.11 11.8 0.0 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.14 AMD21569.1 - 0.029 13.7 0.9 0.27 10.6 0.1 2.6 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.16 AMD21569.1 - 0.037 13.2 0.1 1.5 8.0 0.0 2.7 2 1 0 2 2 2 0 ADP-ribosylation factor family AAA_30 PF13604.1 AMD21569.1 - 0.041 13.4 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 AMD21569.1 - 0.068 12.8 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 AMD21569.1 - 0.072 13.2 0.0 1.6 8.9 0.0 2.8 3 0 0 3 3 2 0 RNA helicase SRPRB PF09439.5 AMD21569.1 - 0.13 11.4 4.7 0.35 10.0 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit PAC2 PF09754.4 AMD21570.1 - 3.3e-31 108.8 0.0 4e-31 108.5 0.0 1.1 1 0 0 1 1 1 1 PAC2 family HEAT_2 PF13646.1 AMD21571.1 - 3.7e-39 132.8 0.0 1.1e-16 60.8 0.0 3.3 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.11 AMD21571.1 - 2.9e-18 64.4 0.0 6.1e-05 23.1 0.0 6.2 7 0 0 7 7 7 3 PBS lyase HEAT-like repeat HEAT PF02985.17 AMD21571.1 - 5.8e-15 53.9 0.0 0.061 13.4 0.0 6.4 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 AMD21571.1 - 4.5e-11 42.8 0.2 0.0046 17.4 0.0 4.6 3 2 2 5 5 5 3 HEAT-like repeat Arm PF00514.18 AMD21571.1 - 0.0022 17.7 0.3 0.51 10.2 0.0 3.6 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat DUF310 PF03750.8 AMD21571.1 - 0.079 13.1 0.0 0.31 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF310) Cohesin_HEAT PF12765.2 AMD21571.1 - 0.094 12.6 0.5 0.95 9.4 0.0 2.8 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Ham1p_like PF01725.11 AMD21572.1 - 7.8e-51 172.1 0.0 8.7e-51 171.9 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Xpo1 PF08389.7 AMD21573.1 - 1.2e-42 145.3 0.8 8.4e-42 142.5 0.1 2.8 2 0 0 2 2 2 1 Exportin 1-like protein DUF1045 PF06299.7 AMD21573.1 - 0.11 12.1 0.0 0.33 10.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) DUF3861 PF12977.2 AMD21574.1 - 0.12 12.4 2.6 0.12 12.4 0.5 1.9 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) Rep_fac_C PF08542.6 AMD21575.1 - 2.3e-16 59.5 0.0 5.7e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.24 AMD21575.1 - 5.4e-16 58.9 0.0 1.1e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 AMD21575.1 - 7.1e-15 55.0 0.0 1.8e-14 53.7 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 AMD21575.1 - 6.6e-12 44.8 0.1 2.2e-09 36.5 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 AMD21575.1 - 2.1e-06 27.9 0.0 1.2e-05 25.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 AMD21575.1 - 4.5e-06 25.8 0.0 9.3e-06 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 AMD21575.1 - 3.2e-05 23.6 0.0 4.8e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AMD21575.1 - 5.3e-05 23.2 0.1 0.0009 19.2 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.16 AMD21575.1 - 8.8e-05 21.7 0.0 0.0027 16.9 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 AMD21575.1 - 0.00012 22.0 0.0 0.00048 20.0 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 AMD21575.1 - 0.00021 20.9 0.0 0.00044 19.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain DUF815 PF05673.8 AMD21575.1 - 0.00072 18.5 0.0 0.0012 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.1 AMD21575.1 - 0.00094 18.8 0.2 0.002 17.7 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 AMD21575.1 - 0.0028 17.2 0.0 0.0069 15.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 AMD21575.1 - 0.0039 17.0 0.1 0.017 14.9 0.0 2.0 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit DNA_pol3_delta PF06144.8 AMD21575.1 - 0.0042 16.6 0.4 0.16 11.4 0.0 2.6 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_17 PF13207.1 AMD21575.1 - 0.0055 17.5 0.0 0.041 14.6 0.0 2.3 1 1 0 2 2 2 1 AAA domain AAA_23 PF13476.1 AMD21575.1 - 0.0062 16.8 0.1 0.014 15.7 0.1 1.6 1 1 0 1 1 1 1 AAA domain DNA_pol3_gamma3 PF12169.3 AMD21575.1 - 0.01 15.5 0.3 0.06 13.0 0.0 2.4 3 0 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III SNF2_N PF00176.18 AMD21575.1 - 0.015 14.0 0.0 0.67 8.7 0.0 2.2 1 1 0 2 2 2 0 SNF2 family N-terminal domain DUF2075 PF09848.4 AMD21575.1 - 0.017 14.1 0.0 0.043 12.7 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.9 AMD21575.1 - 0.026 14.2 0.1 0.15 11.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.8 AMD21575.1 - 0.032 12.9 0.0 0.22 10.1 0.0 2.0 2 0 0 2 2 2 0 TIP49 C-terminus Arch_ATPase PF01637.13 AMD21575.1 - 0.043 13.4 0.1 1.3 8.6 0.0 2.6 1 1 1 3 3 3 0 Archaeal ATPase AAA_10 PF12846.2 AMD21575.1 - 0.045 13.1 0.1 0.22 10.9 0.0 2.4 1 1 0 1 1 1 0 AAA-like domain AAA_3 PF07726.6 AMD21575.1 - 0.057 13.0 0.0 0.6 9.7 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 AMD21575.1 - 0.068 12.6 0.1 0.19 11.1 0.0 1.7 1 1 1 2 2 2 0 FtsK/SpoIIIE family AAA_25 PF13481.1 AMD21575.1 - 0.079 12.3 0.1 0.2 11.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 AMD21575.1 - 0.085 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 AMD21575.1 - 0.087 13.1 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 AMD21575.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.7 1 1 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 AMD21575.1 - 0.13 12.5 0.1 3.7 7.8 0.0 2.6 2 1 0 2 2 2 0 ABC transporter Yae1_N PF09811.4 AMD21576.1 - 4.2e-12 45.3 0.1 5.5e-12 45.0 0.1 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Peptidase_M44 PF03410.8 AMD21576.1 - 0.098 10.8 0.0 0.12 10.5 0.0 1.1 1 0 0 1 1 1 0 Protein G1 FAT PF02259.18 AMD21577.1 - 1.8e-137 458.1 2.1 1.8e-137 458.1 1.5 2.5 3 0 0 3 3 3 1 FAT domain DUF3385 PF11865.3 AMD21577.1 - 1.7e-64 216.5 0.7 1.7e-64 216.5 0.5 5.1 6 1 1 7 7 7 1 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.22 AMD21577.1 - 2e-60 204.2 0.1 4.1e-60 203.1 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 AMD21577.1 - 4.1e-43 145.5 4.5 6.5e-43 144.8 0.4 3.3 3 0 0 3 3 3 1 Rapamycin binding domain FATC PF02260.15 AMD21577.1 - 3.8e-18 64.6 0.2 8.8e-18 63.4 0.1 1.7 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.1 AMD21577.1 - 7.7e-13 48.5 4.4 0.29 11.4 0.0 8.3 6 1 2 8 8 8 5 HEAT repeats HEAT_EZ PF13513.1 AMD21577.1 - 1.8e-10 40.9 0.4 0.0014 19.0 0.0 8.0 6 1 1 7 7 7 2 HEAT-like repeat HEAT PF02985.17 AMD21577.1 - 2.6e-05 23.9 10.3 0.65 10.2 0.0 8.1 8 0 0 8 8 8 1 HEAT repeat Vac14_Fab1_bd PF12755.2 AMD21577.1 - 0.11 12.9 9.9 13 6.2 0.0 6.0 6 0 0 6 6 6 0 Vacuolar 14 Fab1-binding region Gp23 PF07068.6 AMD21577.1 - 0.57 8.6 0.1 0.96 7.8 0.1 1.2 1 0 0 1 1 1 0 Major capsid protein Gp23 Actin PF00022.14 AMD21578.1 - 4.1e-89 298.7 0.0 1.1e-88 297.3 0.0 1.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 AMD21578.1 - 2.5e-05 23.0 0.0 0.017 13.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Cpn60_TCP1 PF00118.19 AMD21579.1 - 3.4e-139 464.5 3.8 4e-139 464.3 2.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TFIIS_C PF01096.13 AMD21580.1 - 2.1e-18 65.6 2.1 2.1e-18 65.6 1.5 3.2 4 0 0 4 4 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 AMD21580.1 - 4.7e-08 32.5 9.6 5.2e-07 29.2 0.1 3.0 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit zinc_ribbon_2 PF13240.1 AMD21580.1 - 0.00082 18.7 9.5 1.2 8.6 0.8 4.2 3 1 0 3 3 3 1 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 AMD21580.1 - 0.0012 18.5 3.2 0.018 14.8 0.2 2.5 2 1 1 3 3 3 1 Transposase zinc-ribbon domain DZR PF12773.2 AMD21580.1 - 0.0015 18.2 7.3 0.074 12.8 0.1 3.0 2 1 1 3 3 3 1 Double zinc ribbon RRN7 PF11781.3 AMD21580.1 - 0.0082 15.6 4.0 6.4 6.3 0.2 4.0 4 0 0 4 4 4 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-ribbon_3 PF13248.1 AMD21580.1 - 0.018 14.2 10.0 9.7 5.5 0.1 4.1 3 1 1 4 4 4 0 zinc-ribbon domain Lar_restr_allev PF14354.1 AMD21580.1 - 0.023 14.9 6.9 0.12 12.6 0.3 2.5 2 1 0 2 2 2 0 Restriction alleviation protein Lar DUF2387 PF09526.5 AMD21580.1 - 0.05 13.5 0.3 0.05 13.5 0.2 2.8 2 1 1 3 3 3 0 Probable metal-binding protein (DUF2387) zf-C2HC5 PF06221.8 AMD21580.1 - 0.058 13.1 3.3 1.5 8.6 0.1 3.1 3 0 0 3 3 3 0 Putative zinc finger motif, C2HC5-type Baculo_LEF5_C PF11792.3 AMD21580.1 - 0.073 12.4 0.0 0.073 12.4 0.0 3.3 4 0 0 4 4 4 0 Baculoviridae late expression factor 5 C-terminal domain C1_1 PF00130.17 AMD21580.1 - 0.1 12.3 2.9 5.1 6.8 0.1 2.6 2 2 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ArfGap PF01412.13 AMD21580.1 - 0.1 12.3 3.2 0.78 9.5 0.2 2.1 1 1 1 2 2 2 0 Putative GTPase activating protein for Arf PHD PF00628.24 AMD21580.1 - 0.11 12.1 7.7 1.4 8.6 0.3 2.8 2 1 1 3 3 3 0 PHD-finger zf-TFIIB PF13453.1 AMD21580.1 - 0.12 11.6 2.3 0.2 10.8 0.5 2.1 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-H2C2_2 PF13465.1 AMD21580.1 - 0.2 11.9 6.7 2.9 8.3 0.3 3.6 3 1 0 3 3 3 0 Zinc-finger double domain zf-RING_5 PF14634.1 AMD21580.1 - 0.44 10.3 5.6 4.1 7.2 0.4 3.0 3 0 0 3 3 3 0 zinc-RING finger domain OrfB_Zn_ribbon PF07282.6 AMD21580.1 - 0.47 10.1 7.3 7.1 6.3 1.6 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-C2H2_3 PF13878.1 AMD21580.1 - 0.84 9.2 0.0 0.84 9.2 0.0 3.4 3 1 1 4 4 3 0 zinc-finger of acetyl-transferase ESCO zf-C4_Topoisom PF01396.14 AMD21580.1 - 0.99 8.9 9.3 0.24 10.9 1.5 3.1 2 2 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-C3HC4_4 PF15227.1 AMD21580.1 - 1 9.3 5.7 2 8.3 0.5 3.0 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING Elf1 PF05129.8 AMD21580.1 - 1.3 8.7 5.9 0.31 10.7 0.2 2.4 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zf-RING_3 PF14369.1 AMD21580.1 - 1.5 8.8 10.1 10 6.1 0.1 3.6 3 1 0 3 3 3 0 zinc-finger zinc_ribbon_5 PF13719.1 AMD21580.1 - 1.6 8.4 9.5 8.8 6.0 0.0 3.5 4 0 0 4 4 3 0 zinc-ribbon domain SprT-like PF10263.4 AMD21580.1 - 1.8 8.1 4.4 12 5.4 0.0 2.3 1 1 0 2 2 2 0 SprT-like family Rpr2 PF04032.11 AMD21580.1 - 1.9 8.4 6.7 1.8 8.4 1.6 2.6 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zinc_ribbon_4 PF13717.1 AMD21580.1 - 2 8.2 9.6 11 5.7 0.0 3.5 4 0 0 4 4 3 0 zinc-ribbon domain DUF2072 PF09845.4 AMD21580.1 - 2.3 8.1 4.6 4.4 7.2 0.0 2.8 1 1 1 3 3 3 0 Zn-ribbon containing protein (DUF2072) IBR PF01485.16 AMD21580.1 - 2.3 8.1 9.7 11 5.9 0.7 2.9 2 2 0 2 2 2 0 IBR domain TF_Zn_Ribbon PF08271.7 AMD21580.1 - 2.3 7.5 15.0 1.8 7.9 2.9 3.2 2 2 1 3 3 3 0 TFIIB zinc-binding CpXC PF14353.1 AMD21580.1 - 3.1 7.7 7.6 1.9 8.4 0.1 2.9 1 1 1 3 3 3 0 CpXC protein Zn-ribbon_8 PF09723.5 AMD21580.1 - 3.3 7.7 13.0 14 5.7 0.8 3.4 3 1 0 3 3 3 0 Zinc ribbon domain Rubredoxin PF00301.15 AMD21580.1 - 6 6.8 10.9 2.4 8.1 0.4 3.5 3 1 0 3 3 3 0 Rubredoxin zf-HIT PF04438.11 AMD21580.1 - 8.4 6.1 15.4 15 5.3 0.1 3.8 4 0 0 4 4 4 0 HIT zinc finger zinc-ribbons_6 PF07191.7 AMD21580.1 - 9.7 6.0 10.3 5.6 6.8 0.5 3.2 2 2 0 2 2 2 0 zinc-ribbons LicD PF04991.8 AMD21581.1 - 9.4e-45 153.2 1.7 9.4e-45 153.2 1.2 4.0 3 1 1 4 4 4 1 LicD family GAGA_bind PF06217.7 AMD21581.1 - 0.62 9.9 13.6 1.1 9.1 9.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CAF-1_p150 PF11600.3 AMD21581.1 - 2.6 7.3 55.9 4.7 6.5 38.8 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CN_hydrolase PF00795.17 AMD21582.1 - 3.9e-13 49.1 0.0 5.5e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HLH PF00010.21 AMD21583.1 - 8.3e-12 44.6 3.1 1.9e-11 43.4 2.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain UPF0175 PF03683.8 AMD21583.1 - 0.018 14.4 0.1 0.062 12.7 0.0 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) Macoilin PF09726.4 AMD21583.1 - 0.026 12.8 9.7 0.032 12.5 6.7 1.1 1 0 0 1 1 1 0 Transmembrane protein MRP-S31 PF15433.1 AMD21583.1 - 0.074 12.4 15.4 0.015 14.7 7.9 1.8 1 1 1 2 2 2 0 Mitochondrial 28S ribosomal protein S31 SDA1 PF05285.7 AMD21583.1 - 0.2 10.9 22.5 0.25 10.6 15.6 1.2 1 0 0 1 1 1 0 SDA1 CbiG_C PF01890.11 AMD21583.1 - 0.44 10.8 4.1 0.66 10.2 0.2 2.4 2 1 0 2 2 2 0 Cobalamin synthesis G C-terminus LPP20 PF02169.11 AMD21583.1 - 4.5 7.4 7.1 4 7.5 1.9 2.3 2 0 0 2 2 2 0 LPP20 lipoprotein Pkinase PF00069.20 AMD21584.1 - 9.9e-43 146.1 0.1 2.2e-42 145.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21584.1 - 1.6e-10 40.5 0.0 4.4e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 AMD21584.1 - 0.0041 16.1 0.0 0.0075 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 AMD21584.1 - 0.011 14.7 0.0 0.041 12.8 0.0 1.9 1 1 0 1 1 1 0 Kinase-like AAA PF00004.24 AMD21585.1 - 2.3e-53 179.8 0.0 6.3e-44 149.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 AMD21585.1 - 5.2e-22 77.6 0.0 1.3e-21 76.3 0.0 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 AMD21585.1 - 1.3e-12 48.0 8.0 3.2e-06 27.2 0.0 5.4 4 2 2 6 6 5 2 AAA ATPase domain NACHT PF05729.7 AMD21585.1 - 8.5e-09 35.2 0.7 4.1e-05 23.2 0.0 3.7 3 1 0 3 3 3 1 NACHT domain AAA_22 PF13401.1 AMD21585.1 - 3.3e-08 33.7 0.1 0.025 14.6 0.0 3.8 2 2 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 AMD21585.1 - 1.9e-07 31.0 0.0 0.00019 21.2 0.0 3.1 2 1 1 3 3 3 1 Archaeal ATPase Bac_DnaA PF00308.13 AMD21585.1 - 1.9e-07 30.9 0.0 2e-05 24.3 0.0 3.0 3 1 0 3 3 3 1 Bacterial dnaA protein AAA_14 PF13173.1 AMD21585.1 - 7.1e-07 29.1 0.0 0.022 14.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 AMD21585.1 - 3.4e-06 27.0 0.0 0.0029 17.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 AMD21585.1 - 5.3e-05 22.9 0.1 0.76 9.5 0.0 3.4 2 2 1 3 3 3 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 AMD21585.1 - 5.6e-05 23.9 0.0 0.0072 17.1 0.0 3.0 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.8 AMD21585.1 - 0.00029 19.6 0.1 0.091 11.4 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus RuvB_N PF05496.7 AMD21585.1 - 0.00031 19.8 0.0 0.0057 15.7 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 AMD21585.1 - 0.00045 19.6 0.1 0.3 10.5 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein NB-ARC PF00931.17 AMD21585.1 - 0.00045 19.1 0.0 0.29 9.9 0.0 2.2 2 0 0 2 2 2 2 NB-ARC domain RNA_helicase PF00910.17 AMD21585.1 - 0.00048 20.2 0.0 1.1 9.5 0.0 3.1 3 0 0 3 3 3 1 RNA helicase AAA_33 PF13671.1 AMD21585.1 - 0.0012 18.7 0.0 0.054 13.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.4 AMD21585.1 - 0.0026 16.7 0.0 0.82 8.5 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Molydop_binding PF01568.16 AMD21585.1 - 0.0034 17.1 0.0 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 Molydopterin dinucleotide binding domain AAA_25 PF13481.1 AMD21585.1 - 0.0062 15.9 0.1 8.5 5.7 0.1 3.5 2 1 1 3 3 3 0 AAA domain AAA_19 PF13245.1 AMD21585.1 - 0.0071 16.0 0.0 2.5 7.9 0.0 3.1 2 0 0 2 2 2 1 Part of AAA domain AAA_3 PF07726.6 AMD21585.1 - 0.0079 15.8 0.0 0.44 10.1 0.0 2.7 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.1 AMD21585.1 - 0.01 15.7 0.1 0.75 9.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 AMD21585.1 - 0.012 15.9 0.2 35 4.6 0.0 3.9 3 1 1 4 4 4 0 ABC transporter Zeta_toxin PF06414.7 AMD21585.1 - 0.016 14.3 0.0 0.17 10.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Viral_helicase1 PF01443.13 AMD21585.1 - 0.023 14.2 0.0 0.096 12.1 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.16 AMD21585.1 - 0.031 13.4 0.7 0.83 8.7 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 AMD21585.1 - 0.046 14.0 0.0 0.45 10.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 AMD21585.1 - 0.07 12.5 0.2 10 5.5 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Cytidylate_kin2 PF13189.1 AMD21585.1 - 0.094 12.6 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 Cytidylate kinase-like family Sigma54_activat PF00158.21 AMD21585.1 - 0.11 11.9 0.1 17 4.8 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.10 AMD21585.1 - 0.13 11.9 0.0 4.7 6.9 0.0 2.3 2 0 0 2 2 2 0 NTPase MobB PF03205.9 AMD21585.1 - 0.13 11.9 0.1 0.49 10.1 0.0 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 AMD21585.1 - 0.19 11.1 0.0 2.7 7.4 0.0 2.5 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Clat_adaptor_s PF01217.15 AMD21586.1 - 8.3e-45 151.9 0.1 9.4e-45 151.8 0.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Thymidylate_kin PF02223.12 AMD21587.1 - 1.8e-43 148.0 0.0 2e-43 147.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.1 AMD21587.1 - 0.00047 20.1 0.0 0.00065 19.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD21587.1 - 0.011 15.9 0.1 0.038 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 AMD21587.1 - 0.033 14.0 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 AMD21587.1 - 0.1 12.5 0.1 0.23 11.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain SUR7 PF06687.7 AMD21588.1 - 2.5e-33 115.4 3.2 3e-33 115.1 2.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF4386 PF14329.1 AMD21588.1 - 0.057 12.9 7.8 0.21 11.0 4.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4386) Claudin_2 PF13903.1 AMD21588.1 - 1.2 8.8 12.8 0.22 11.1 3.5 2.6 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Wzy_C PF04932.10 AMD21588.1 - 1.3 8.8 4.9 6.1 6.5 2.8 2.3 2 1 0 2 2 2 0 O-Antigen ligase ABC2_membrane_3 PF12698.2 AMD21588.1 - 5.1 6.0 9.9 9.3 5.1 6.9 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-HIT PF04438.11 AMD21589.1 - 3.5e-09 36.1 11.4 6.5e-09 35.2 7.9 1.4 1 0 0 1 1 1 1 HIT zinc finger Ins_P5_2-kin PF06090.7 AMD21589.1 - 0.037 13.0 0.5 0.039 12.9 0.3 1.1 1 0 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase Inhibitor_I71 PF12628.2 AMD21589.1 - 0.059 13.0 0.2 0.08 12.5 0.2 1.2 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor PolC_DP2 PF03833.8 AMD21589.1 - 0.28 8.7 2.4 0.3 8.7 1.7 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF4428 PF14471.1 AMD21589.1 - 3.9 7.2 8.2 4.3 7.1 4.6 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) Suc_Fer-like PF06999.7 AMD21590.1 - 4.4e-35 121.7 0.0 6.5e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 Sucrase/ferredoxin-like CPSF_A PF03178.10 AMD21591.1 - 8.7e-57 192.6 3.1 5.2e-55 186.7 1.0 3.4 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.4 AMD21591.1 - 5.8e-27 93.9 1.0 1.5e-25 89.3 0.0 3.2 2 2 1 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Myc_N PF01056.13 AMD21591.1 - 0.71 8.9 11.9 3.8 6.5 0.0 2.4 2 0 0 2 2 2 0 Myc amino-terminal region Gsf2 PF11055.3 AMD21592.1 - 2.1e-160 533.3 0.8 2.3e-160 533.2 0.6 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 DUF2087 PF09860.4 AMD21593.1 - 0.02 14.6 0.6 8 6.3 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) LRR_4 PF12799.2 AMD21594.1 - 0.0004 19.9 16.6 0.0091 15.5 1.0 5.7 2 2 2 4 4 4 1 Leucine Rich repeats (2 copies) Soyouz_module PF14313.1 AMD21594.1 - 0.014 14.9 0.1 0.057 12.9 0.0 2.0 2 0 0 2 2 2 0 N-terminal region of Paramyxovirinae phosphoprotein (P) CDC27 PF09507.5 AMD21594.1 - 0.058 12.6 20.6 0.076 12.2 14.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 BUD22 PF09073.5 AMD21594.1 - 0.53 9.2 18.4 0.73 8.8 12.7 1.1 1 0 0 1 1 1 0 BUD22 LRR_7 PF13504.1 AMD21594.1 - 2.5 8.6 16.3 25 5.6 0.1 6.7 5 1 1 6 6 6 0 Leucine rich repeat Suf PF05843.9 AMD21595.1 - 0.00035 20.3 2.2 0.3 10.7 0.1 3.3 3 1 0 3 3 3 2 Suppressor of forked protein (Suf) TPR_15 PF13429.1 AMD21595.1 - 0.002 17.2 0.1 2.9 6.8 0.0 3.3 3 1 1 4 4 4 3 Tetratricopeptide repeat BNIP3 PF06553.7 AMD21596.1 - 0.096 12.0 3.2 0.082 12.2 0.8 1.9 2 0 0 2 2 2 0 BNIP3 Atg31 PF09795.4 AMD21597.1 - 4.7e-23 81.6 7.6 2.7e-22 79.1 5.3 1.8 1 1 0 1 1 1 1 Autophagy-related protein 31 DEAD PF00270.24 AMD21598.1 - 1.4e-41 141.8 4.6 3.3e-41 140.6 1.9 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21598.1 - 6.5e-27 93.2 0.4 2.5e-26 91.3 0.1 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 AMD21598.1 - 1.2e-05 24.9 0.3 4e-05 23.2 0.1 1.9 1 1 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 AMD21598.1 - 0.00011 22.2 0.1 0.0005 20.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 AMD21598.1 - 0.0097 15.5 0.6 0.029 13.9 0.4 1.8 2 1 0 2 2 2 1 AAA domain ResIII PF04851.10 AMD21598.1 - 0.015 15.1 0.1 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 AMD21598.1 - 0.04 13.5 0.0 0.084 12.5 0.0 1.6 1 1 0 1 1 1 0 Helicase AAA_11 PF13086.1 AMD21598.1 - 0.052 13.1 0.7 0.16 11.5 0.5 1.9 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.9 AMD21598.1 - 0.067 12.9 1.5 0.097 12.4 0.1 2.0 2 1 0 2 2 2 0 Flavivirus DEAD domain Helicase_C_2 PF13307.1 AMD21598.1 - 0.076 12.9 0.1 0.5 10.3 0.1 2.3 2 1 0 2 2 2 0 Helicase C-terminal domain UvrD-helicase PF00580.16 AMD21598.1 - 0.27 10.4 1.9 0.33 10.1 0.7 1.5 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain PhoH PF02562.11 AMD21598.1 - 0.29 10.3 3.4 0.92 8.6 2.4 1.9 1 1 0 1 1 1 0 PhoH-like protein PRK PF00485.13 AMD21599.1 - 1.7e-08 34.2 0.1 2.7e-08 33.5 0.1 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AA_permease PF00324.16 AMD21601.1 - 2.8e-109 365.6 38.3 3.4e-109 365.3 26.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD21601.1 - 1.9e-35 122.2 40.9 2.4e-35 121.9 28.4 1.1 1 0 0 1 1 1 1 Amino acid permease Bac_surface_Ag PF01103.18 AMD21602.1 - 1.8e-25 90.0 1.5 2.3e-25 89.7 1.1 1.1 1 0 0 1 1 1 1 Surface antigen FHA PF00498.21 AMD21603.1 - 1.2e-05 25.2 0.0 3.4e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 FHA domain BRCT PF00533.21 AMD21603.1 - 0.0041 17.2 0.0 0.043 13.9 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Aldo_ket_red PF00248.16 AMD21604.1 - 2.8e-56 190.4 0.0 3.4e-56 190.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Kei1 PF08552.6 AMD21605.1 - 5.2e-42 143.6 14.4 2.5e-35 121.8 5.3 2.0 1 1 1 2 2 2 2 Inositolphosphorylceramide synthase subunit Kei1 RIO1 PF01163.17 AMD21606.1 - 3e-72 241.9 0.8 3e-72 241.9 0.6 2.4 3 0 0 3 3 3 1 RIO1 family APH PF01636.18 AMD21606.1 - 0.059 13.1 0.0 0.5 10.0 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF2201_N PF13203.1 AMD21606.1 - 2.4 7.2 14.0 5 6.1 9.7 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain TLD PF07534.11 AMD21607.1 - 6.1e-27 94.3 0.0 5.1e-26 91.3 0.0 2.2 1 1 0 1 1 1 1 TLD NUC153 PF08159.7 AMD21608.1 - 5.9e-13 48.1 4.0 5.9e-13 48.1 2.8 3.5 3 0 0 3 3 3 2 NUC153 domain MEF2_binding PF09047.5 AMD21608.1 - 0.061 12.9 2.9 0.17 11.5 2.0 1.7 1 0 0 1 1 1 0 MEF2 binding MSC PF09402.5 AMD21609.1 - 9.4e-118 392.7 3.3 1.5e-117 392.0 2.3 1.3 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.2 AMD21609.1 - 4.9e-13 48.3 0.4 2.7e-12 46.0 0.3 2.4 1 0 0 1 1 1 1 HeH/LEM domain DUF3419 PF11899.3 AMD21609.1 - 0.0085 14.8 0.0 0.014 14.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) HECT PF00632.20 AMD21610.1 - 2.8e-91 305.9 2.6 1e-90 304.1 0.1 2.8 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.7 AMD21610.1 - 1e-74 251.8 7.6 1e-74 251.8 5.3 2.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF908) DUF913 PF06025.7 AMD21610.1 - 8.6e-43 146.5 0.1 8.6e-43 146.5 0.1 2.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) DUF4414 PF14377.1 AMD21610.1 - 1.6e-12 47.2 1.3 1e-11 44.7 0.9 2.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4414) Rad52_Rad22 PF04098.10 AMD21611.1 - 1.4e-56 190.4 0.0 2.6e-56 189.6 0.0 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ndc1_Nup PF09531.5 AMD21612.1 - 1.4e-117 393.6 20.1 3.8e-117 392.2 14.0 1.6 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Na_H_Exchanger PF00999.16 AMD21613.1 - 1.5e-64 217.9 36.0 1.9e-64 217.5 24.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DinB PF05163.7 AMD21613.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 DinB family Guanylate_kin PF00625.16 AMD21614.1 - 3.8e-69 231.8 0.0 4.1e-69 231.6 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.1 AMD21614.1 - 3.1e-06 27.5 0.0 7.2e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AMD21614.1 - 1.1e-05 25.4 0.0 7.4e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 AMD21614.1 - 1.5e-05 24.8 0.0 5.1e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD21614.1 - 6.3e-05 23.7 0.0 0.00015 22.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD21614.1 - 6.4e-05 23.1 0.0 0.00052 20.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 AMD21614.1 - 0.0002 21.3 0.0 0.0052 16.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 AMD21614.1 - 0.00024 21.4 0.0 0.00029 21.1 0.0 1.6 1 1 0 1 1 1 1 ABC transporter RNA_helicase PF00910.17 AMD21614.1 - 0.0015 18.6 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 RNA helicase Miro PF08477.8 AMD21614.1 - 0.0031 17.9 0.0 0.0073 16.7 0.0 1.6 1 1 0 1 1 1 1 Miro-like protein DUF258 PF03193.11 AMD21614.1 - 0.0033 16.6 0.0 0.0063 15.7 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 T2SE PF00437.15 AMD21614.1 - 0.0036 16.2 0.0 0.0065 15.4 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.1 AMD21614.1 - 0.0037 17.1 0.0 0.0053 16.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 AMD21614.1 - 0.0043 17.2 0.2 0.014 15.5 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 AMD21614.1 - 0.0062 16.8 1.2 0.01 16.1 0.8 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 AMD21614.1 - 0.0063 16.0 0.4 0.018 14.5 0.1 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.7 AMD21614.1 - 0.0085 15.7 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_21 PF13304.1 AMD21614.1 - 0.0089 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 AMD21614.1 - 0.013 15.4 0.0 0.022 14.7 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_10 PF12846.2 AMD21614.1 - 0.013 14.9 0.6 0.015 14.7 0.4 1.5 1 1 0 1 1 1 0 AAA-like domain Arch_ATPase PF01637.13 AMD21614.1 - 0.014 15.0 0.0 0.017 14.7 0.0 1.5 1 1 0 1 1 1 0 Archaeal ATPase AAA_19 PF13245.1 AMD21614.1 - 0.029 14.1 0.0 0.069 12.9 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Rad17 PF03215.10 AMD21614.1 - 0.048 12.3 0.0 0.054 12.1 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_24 PF13479.1 AMD21614.1 - 0.073 12.6 1.4 0.2 11.2 1.0 2.1 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 AMD21614.1 - 0.086 12.5 0.0 0.18 11.5 0.0 1.5 2 0 0 2 2 1 0 NTPase HIG_1_N PF04588.8 AMD21615.1 - 5.6e-20 70.8 0.7 7.8e-20 70.3 0.5 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF1068 PF06364.7 AMD21615.1 - 0.002 17.7 2.1 0.0051 16.4 0.9 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1068) AAA_23 PF13476.1 AMD21615.1 - 0.036 14.3 6.4 0.037 14.3 4.5 1.2 1 0 0 1 1 1 0 AAA domain DUF342 PF03961.8 AMD21615.1 - 0.047 12.1 3.2 0.049 12.0 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) AAA_13 PF13166.1 AMD21615.1 - 0.077 11.4 9.7 0.11 10.9 6.7 1.2 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 AMD21615.1 - 0.11 12.1 8.5 0.17 11.4 5.9 1.4 1 0 0 1 1 1 0 IncA protein Hormone_1 PF00103.15 AMD21615.1 - 0.29 10.4 4.0 0.43 9.8 2.8 1.2 1 0 0 1 1 1 0 Somatotropin hormone family PEARLI-4 PF05278.7 AMD21615.1 - 0.64 9.3 11.4 0.87 8.8 7.9 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Prefoldin_2 PF01920.15 AMD21615.1 - 0.91 9.3 13.9 0.44 10.3 7.9 1.8 1 1 0 1 1 1 0 Prefoldin subunit OPA3 PF07047.7 AMD21615.1 - 0.95 9.2 7.0 1.9 8.2 4.8 1.6 1 1 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Spc7 PF08317.6 AMD21615.1 - 1.1 7.9 13.2 1.7 7.2 7.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF4485 PF14846.1 AMD21615.1 - 1.2 8.9 4.9 1.2 8.8 2.3 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4485) CCDC-167 PF15188.1 AMD21615.1 - 1.2 9.1 9.3 1.9 8.4 6.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 HAUS6_N PF14661.1 AMD21615.1 - 1.6 8.0 8.9 2.1 7.6 6.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus APG6 PF04111.7 AMD21615.1 - 4.7 6.1 12.0 5.9 5.8 8.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 ubiquitin PF00240.18 AMD21616.1 - 0.00019 20.7 0.0 0.00048 19.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family AhpC-TSA PF00578.16 AMD21617.1 - 5.2e-35 119.8 0.0 9.9e-35 118.9 0.0 1.4 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 AMD21617.1 - 6.9e-20 71.0 0.0 1.1e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 AMD21617.1 - 2.5e-10 39.8 0.1 4.5e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Lipocalin_2 PF08212.7 AMD21617.1 - 0.017 14.9 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipocalin-like domain Homeobox PF00046.24 AMD21618.1 - 2.7e-18 65.2 8.2 5.4e-18 64.3 5.7 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 AMD21618.1 - 0.00079 19.0 0.4 0.00079 19.0 0.3 2.5 2 0 0 2 2 2 1 Homeobox KN domain Ribosomal_S13 PF00416.17 AMD21619.1 - 3.2e-42 143.3 1.8 3.7e-42 143.1 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 AMD21619.1 - 0.00046 18.8 0.1 0.00071 18.2 0.0 1.4 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_L4 PF00573.17 AMD21620.1 - 3.9e-49 166.6 0.0 5.2e-49 166.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family U3_assoc_6 PF08640.6 AMD21621.1 - 3e-32 110.2 9.4 3.6e-31 106.7 1.4 3.2 2 1 0 2 2 2 2 U3 small nucleolar RNA-associated protein 6 Suf PF05843.9 AMD21621.1 - 0.12 12.1 13.7 0.061 13.0 5.2 3.8 2 1 1 3 3 3 0 Suppressor of forked protein (Suf) TPR_14 PF13428.1 AMD21621.1 - 0.16 12.7 0.0 44 5.0 0.0 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat ZZ PF00569.12 AMD21622.1 - 3.9e-17 61.5 8.0 6.5e-17 60.8 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.12 AMD21622.1 - 6.5e-14 51.8 1.0 5.8e-12 45.5 0.0 3.1 3 0 0 3 3 3 1 SWIRM domain Myb_DNA-binding PF00249.26 AMD21622.1 - 7.3e-07 29.1 0.7 3.1e-06 27.1 0.0 2.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD21622.1 - 0.00044 20.2 0.5 0.004 17.2 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Ribosomal_S17e PF00833.13 AMD21623.1 - 6.1e-56 187.4 0.4 7.3e-56 187.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal S17 ECM11 PF15463.1 AMD21624.1 - 2.7e-28 99.0 3.1 2.7e-28 99.0 2.1 2.8 3 0 0 3 3 3 2 Extracellular mutant protein 11 DUF676 PF05057.9 AMD21625.1 - 4.4e-42 143.8 0.0 7.1e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 AMD21625.1 - 0.00012 21.7 0.0 0.00028 20.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.6 AMD21625.1 - 0.0049 15.9 0.0 0.0087 15.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.2 AMD21625.1 - 0.016 14.9 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.8 AMD21625.1 - 0.023 14.2 0.0 0.04 13.4 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.2 AMD21625.1 - 0.027 14.3 0.0 0.077 12.8 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD21625.1 - 0.068 12.7 0.0 0.84 9.1 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold Med13_C PF06333.7 AMD21626.1 - 4.1e-90 302.3 11.8 5.4e-59 199.8 1.4 3.1 2 1 1 3 3 3 2 Mediator complex subunit 13 C-terminal Nse5 PF08691.5 AMD21627.1 - 4.5e-98 328.9 2.2 5.5e-98 328.6 1.5 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Pribosyltran PF00156.22 AMD21628.1 - 4e-15 55.6 0.0 5.3e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 AMD21628.1 - 0.0066 15.6 0.0 0.0082 15.3 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_3 PF15610.1 AMD21628.1 - 0.062 12.2 0.0 0.083 11.7 0.0 1.1 1 0 0 1 1 1 0 PRTase ComF-like DOT1 PF08123.8 AMD21629.1 - 6.4e-86 286.8 0.0 9.8e-86 286.2 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_4 PF02390.12 AMD21629.1 - 0.038 13.0 0.0 0.088 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase UDG PF03167.14 AMD21630.1 - 6e-23 81.0 0.0 1.4e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Abhydrolase_5 PF12695.2 AMD21631.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 AMD21631.1 - 0.14 12.0 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family LRS4 PF10422.4 AMD21632.1 - 9.3e-24 84.1 29.9 6.1e-23 81.4 20.7 2.3 1 1 0 1 1 1 1 Monopolin complex subunit LRS4 CARD PF00619.16 AMD21632.1 - 0.25 11.1 5.8 0.11 12.3 1.8 2.1 3 0 0 3 3 3 0 Caspase recruitment domain TfuA PF07812.7 AMD21632.1 - 0.27 10.6 1.7 0.67 9.4 0.2 2.0 2 0 0 2 2 2 0 TfuA-like protein DUF1974 PF09317.6 AMD21632.1 - 0.78 9.0 9.4 0.1 12.0 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) DUF972 PF06156.8 AMD21632.1 - 5.9 7.2 19.2 0.15 12.4 6.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF972) OST3_OST6 PF04756.8 AMD21633.1 - 8.6e-22 77.4 14.9 1.6e-21 76.5 10.3 1.5 1 0 0 1 1 1 1 OST3 / OST6 family Thioredoxin PF00085.15 AMD21633.1 - 2.1e-06 27.3 0.1 4e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Halogen_Hydrol PF10112.4 AMD21633.1 - 0.66 9.3 0.0 0.66 9.3 0.0 2.5 3 1 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein EamA PF00892.15 AMD21634.1 - 1.1e-09 38.4 33.1 7.8e-09 35.6 0.9 3.3 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.6 AMD21634.1 - 0.0013 17.7 11.1 0.0013 17.7 7.7 1.6 2 0 0 2 2 2 1 UAA transporter family DUF2422 PF10337.4 AMD21635.1 - 0.26 10.0 0.4 0.64 8.7 0.0 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF2422) PIG-P PF08510.7 AMD21636.1 - 2.4e-32 111.2 1.1 2.9e-32 110.9 0.8 1.1 1 0 0 1 1 1 1 PIG-P TrkH PF02386.11 AMD21636.1 - 0.051 12.1 1.2 0.061 11.8 0.8 1.1 1 0 0 1 1 1 0 Cation transport protein Ion_trans_N PF08412.5 AMD21636.1 - 0.51 9.6 5.7 5.2 6.4 4.0 2.2 2 1 0 2 2 2 0 Ion transport protein N-terminal Metallophos PF00149.23 AMD21637.1 - 5.2e-39 133.7 0.2 7.7e-39 133.1 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LCM PF04072.9 AMD21638.1 - 7.5e-23 81.0 0.1 1.4e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase TAFII28 PF04719.9 AMD21639.1 - 6e-23 80.4 0.6 6e-23 80.4 0.4 2.3 3 0 0 3 3 3 1 hTAFII28-like protein conserved region PIG-S PF10510.4 AMD21640.1 - 3.4e-129 431.8 7.8 4.1e-129 431.5 5.4 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein DUF1611 PF07755.6 AMD21640.1 - 0.14 10.7 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1611) Methyltransf_11 PF08241.7 AMD21641.1 - 4.2e-11 43.1 0.0 7.3e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD21641.1 - 1.2e-06 28.3 0.0 6.1e-06 26.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD21641.1 - 1.5e-05 25.3 0.0 3.3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD21641.1 - 2e-05 24.1 0.0 3.1e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD21641.1 - 0.00069 19.9 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD21641.1 - 0.0018 18.7 0.0 0.0032 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UBA_4 PF14555.1 AMD21642.1 - 8.1e-12 44.4 0.0 1.6e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.15 AMD21642.1 - 4e-10 39.6 0.0 8.5e-09 35.3 0.0 3.0 3 1 0 3 3 3 1 UBX domain DUF2220 PF09983.4 AMD21642.1 - 1.8 7.7 6.5 3.3 6.8 4.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) RRM_1 PF00076.17 AMD21643.1 - 9e-30 102.1 0.6 6.4e-18 64.1 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21643.1 - 7.3e-18 64.3 0.1 1.4e-12 47.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21643.1 - 1.6e-14 53.4 0.0 4e-12 45.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.6 AMD21643.1 - 0.00021 21.1 0.0 0.00036 20.4 0.0 1.3 1 0 0 1 1 1 1 RNA binding domain Limkain-b1 PF11608.3 AMD21643.1 - 0.039 13.6 0.0 5.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 M16C_assoc PF08367.6 AMD21644.1 - 1.3e-73 246.8 0.8 1.3e-73 246.8 0.5 1.7 2 0 0 2 2 2 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 AMD21644.1 - 6e-31 107.5 0.1 4.2e-16 59.1 0.0 3.1 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 AMD21644.1 - 6.9e-07 29.1 0.5 1.3e-05 24.9 0.0 3.1 3 1 0 3 3 3 1 Insulinase (Peptidase family M16) EMP24_GP25L PF01105.19 AMD21645.1 - 7.5e-40 136.5 0.0 8.4e-40 136.4 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.7 AMD21645.1 - 0.021 13.0 0.3 0.024 12.8 0.2 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA COX2-transmemb PF09125.5 AMD21645.1 - 0.037 13.5 0.2 0.078 12.5 0.1 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane DASH_Dad2 PF08654.5 AMD21645.1 - 0.098 12.6 0.1 0.16 11.9 0.1 1.4 1 1 0 1 1 1 0 DASH complex subunit Dad2 Rad33 PF08730.5 AMD21646.1 - 3.4e-37 127.5 1.9 2.2e-35 121.6 1.3 2.0 1 1 0 1 1 1 1 Rad33 Spt5-NGN PF03439.8 AMD21647.1 - 2.2e-21 75.3 0.0 6e-21 73.9 0.0 1.8 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.3 AMD21647.1 - 1.5e-16 60.7 19.1 1.5e-16 60.7 13.2 3.6 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.24 AMD21647.1 - 3.1e-14 52.0 5.3 0.00031 20.3 0.0 4.7 4 0 0 4 4 4 4 KOW motif SPT6_acidic PF14632.1 AMD21647.1 - 0.0044 17.1 23.2 0.0044 17.1 16.1 3.0 1 1 1 2 2 2 1 Acidic N-terminal SPT6 CTD PF12815.2 AMD21647.1 - 0.0046 17.3 32.9 0.0046 17.3 22.8 2.9 2 1 0 2 2 2 1 Spt5 C-terminal nonapeptide repeat binding Spt4 Ribosomal_L33 PF00471.15 AMD21648.1 - 0.0052 16.9 0.2 0.035 14.3 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L33 eIF3g PF12353.3 AMD21649.1 - 9.3e-43 145.2 0.2 1.4e-42 144.6 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 AMD21649.1 - 6.3e-12 44.9 0.0 1.1e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21649.1 - 5.3e-09 35.9 0.0 1.2e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21649.1 - 4.5e-07 29.6 0.0 1.2e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 AMD21649.1 - 0.052 13.4 1.0 0.083 12.8 0.7 1.3 1 0 0 1 1 1 0 Zinc knuckle Abhydrolase_3 PF07859.8 AMD21650.1 - 3.3e-08 33.3 0.0 3.7e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 AMD21650.1 - 7.4e-05 21.5 0.0 0.00012 20.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_6 PF12697.2 AMD21650.1 - 0.0007 19.5 0.0 0.00078 19.3 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 AMD21650.1 - 0.00092 18.4 0.1 0.0024 17.1 0.1 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 AMD21650.1 - 0.0017 18.1 0.0 0.0025 17.5 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2305 PF10230.4 AMD21650.1 - 0.0032 16.9 0.1 0.0052 16.2 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_1 PF00561.15 AMD21650.1 - 0.022 14.3 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 AMD21650.1 - 0.03 13.9 0.5 0.22 11.1 0.3 2.5 1 1 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.7 AMD21650.1 - 0.11 11.8 0.8 0.15 11.3 0.1 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) PCI PF01399.22 AMD21651.1 - 1.1e-10 41.8 0.5 3.4e-10 40.1 0.2 2.1 2 0 0 2 2 2 1 PCI domain Foie-gras_1 PF11817.3 AMD21651.1 - 0.0036 16.8 0.1 0.0068 15.9 0.1 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 Spo0A_C PF08769.6 AMD21651.1 - 0.011 15.6 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal PCI_Csn8 PF10075.4 AMD21651.1 - 0.037 13.7 0.5 0.15 11.8 0.1 2.2 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 TPR_19 PF14559.1 AMD21651.1 - 0.064 13.6 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Thioredoxin_8 PF13905.1 AMD21651.1 - 0.11 12.6 0.4 0.27 11.3 0.3 1.7 1 0 0 1 1 1 0 Thioredoxin-like PX PF00787.19 AMD21652.1 - 2.8e-15 56.1 0.5 9.8e-15 54.3 0.0 2.2 3 0 0 3 3 3 1 PX domain MutS_III PF05192.13 AMD21652.1 - 0.0043 16.8 7.8 0.085 12.6 2.0 2.5 1 1 1 2 2 2 2 MutS domain III Vps5 PF09325.5 AMD21652.1 - 0.033 13.4 12.1 0.0087 15.3 5.1 2.0 2 0 0 2 2 2 0 Vps5 C terminal like Fib_alpha PF08702.5 AMD21652.1 - 0.41 10.7 6.6 4.1 7.5 0.6 3.0 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Mnd1 PF03962.10 AMD21652.1 - 2.3 7.8 12.3 0.12 12.0 2.3 2.7 2 1 0 3 3 3 0 Mnd1 family DUF489 PF04356.7 AMD21652.1 - 3.1 7.3 6.9 15 5.1 0.6 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF489) BLOC1_2 PF10046.4 AMD21652.1 - 3.4 7.8 9.6 7.4 6.7 0.1 3.5 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Dynein_light PF01221.13 AMD21653.1 - 1.6e-34 117.7 0.1 1.7e-34 117.6 0.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Kinesin PF00225.18 AMD21654.1 - 2.2e-99 332.3 2.6 3.3e-99 331.7 1.8 1.2 1 0 0 1 1 1 1 Kinesin motor domain EzrA PF06160.7 AMD21654.1 - 0.00068 17.9 3.7 0.0012 17.1 2.6 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4164 PF13747.1 AMD21654.1 - 0.02 15.0 4.2 0.13 12.4 1.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF972 PF06156.8 AMD21654.1 - 0.19 12.1 4.6 4.2 7.7 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF972) AMPKBI PF04739.10 AMD21655.1 - 3e-27 94.4 0.9 3e-27 94.4 0.6 2.8 2 2 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interation domain bZIP_1 PF00170.16 AMD21656.1 - 1.9e-06 27.7 11.5 4.4e-06 26.5 8.0 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 AMD21656.1 - 0.022 14.5 15.0 0.022 14.5 10.4 2.3 2 0 0 2 2 2 0 Basic region leucine zipper bZIP_Maf PF03131.12 AMD21656.1 - 5.1 7.4 22.4 0.51 10.6 7.6 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor Sterol_MT_C PF08498.5 AMD21657.1 - 3.1e-29 100.7 0.7 4.6e-29 100.1 0.5 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 AMD21657.1 - 9.6e-20 70.8 0.0 1.8e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD21657.1 - 4.3e-16 58.8 0.0 6.2e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AMD21657.1 - 9.9e-14 51.3 0.0 1.7e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AMD21657.1 - 4.7e-11 42.9 0.0 9.7e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AMD21657.1 - 5.6e-11 41.9 0.0 8.3e-11 41.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 AMD21657.1 - 9.9e-11 41.2 0.1 1.4e-10 40.7 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 AMD21657.1 - 4.4e-10 39.9 0.0 8.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD21657.1 - 1.2e-09 38.6 0.0 2.5e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AMD21657.1 - 2.5e-05 24.3 0.0 5.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 AMD21657.1 - 4.4e-05 23.0 0.7 9.1e-05 22.0 0.5 1.5 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.15 AMD21657.1 - 0.018 14.1 0.0 0.031 13.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase UPF0020 PF01170.13 AMD21657.1 - 0.054 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 MetW PF07021.7 AMD21657.1 - 0.076 12.3 0.0 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW DOT1 PF08123.8 AMD21657.1 - 0.078 12.2 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Histone methylation protein DOT1 Sugar_tr PF00083.19 AMD21658.1 - 1.3e-28 99.8 33.1 2.3e-20 72.5 6.6 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 AMD21658.1 - 5.7e-19 68.0 41.1 4.4e-11 42.1 14.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CYSTM PF12734.2 AMD21660.1 - 0.12 12.4 14.6 0.25 11.4 10.1 1.5 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance PIP5K PF01504.13 AMD21661.1 - 2.1e-85 285.8 0.2 3.1e-85 285.3 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase eIF-5a PF01287.15 AMD21662.1 - 4.1e-28 97.1 0.5 6.3e-28 96.5 0.3 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 AMD21662.1 - 0.00028 20.5 0.5 0.00052 19.6 0.4 1.5 1 0 0 1 1 1 1 KOW motif EFP_N PF08207.7 AMD21662.1 - 0.0063 16.3 0.0 0.0099 15.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain MCM PF00493.18 AMD21663.1 - 8.2e-128 425.8 0.3 1.2e-127 425.3 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 AMD21663.1 - 3.8e-20 72.5 0.0 1.2e-19 70.9 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 AMD21663.1 - 1.9e-07 30.4 0.0 1.7e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 AMD21663.1 - 0.0049 16.3 0.0 0.014 14.8 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 AMD21663.1 - 0.0064 16.0 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Hydrolase PF00702.21 AMD21664.1 - 7.1e-23 82.1 0.0 1.9e-22 80.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AMD21664.1 - 4.1e-21 76.0 0.0 8.3e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 AMD21664.1 - 2.1e-17 62.9 0.1 5.4e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 AMD21664.1 - 8e-05 22.5 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 AMD21664.1 - 0.0012 18.4 0.1 0.0059 16.2 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 AMD21664.1 - 0.079 12.2 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase RCC1_2 PF13540.1 AMD21664.1 - 0.15 11.7 0.4 1.4 8.6 0.1 2.4 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat DUF4140 PF13600.1 AMD21665.1 - 0.095 13.1 0.6 0.24 11.8 0.4 1.6 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HSP70 PF00012.15 AMD21666.1 - 4e-266 883.7 13.6 4.6e-266 883.5 9.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 AMD21666.1 - 1.4e-15 56.7 2.9 1.3e-13 50.2 0.5 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 AMD21666.1 - 0.0011 18.5 0.0 0.0034 17.0 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Gp-FAR-1 PF05823.7 AMD21666.1 - 0.004 17.1 7.5 0.0086 16.0 5.2 1.5 1 0 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) FtsA PF14450.1 AMD21666.1 - 0.012 15.4 12.9 0.8 9.5 1.4 4.9 3 2 0 3 3 3 0 Cell division protein FtsA DUF2797 PF10977.3 AMD21666.1 - 0.15 11.6 4.9 0.31 10.6 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Hydantoinase_A PF01968.13 AMD21666.1 - 0.29 10.1 13.2 0.18 10.8 0.1 4.0 2 1 1 4 4 4 0 Hydantoinase/oxoprolinase DP PF08781.5 AMD21666.1 - 0.33 10.6 8.2 5.3 6.7 0.1 2.5 2 0 0 2 2 2 0 Transcription factor DP Vps55 PF04133.9 AMD21667.1 - 2.8e-40 136.8 6.4 3.3e-40 136.5 4.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 7tm_6 PF02949.15 AMD21667.1 - 0.0021 16.9 0.7 0.0034 16.2 0.5 1.3 1 0 0 1 1 1 1 7tm Odorant receptor DUF2614 PF11023.3 AMD21667.1 - 7.8 6.3 8.5 16 5.3 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) YPEB PF14620.1 AMD21668.1 - 0.0018 17.3 2.7 0.0018 17.3 1.9 1.7 1 1 1 2 2 2 1 YpeB sporulation Borrelia_lipo_1 PF05714.6 AMD21668.1 - 0.012 14.7 8.5 0.023 13.7 5.9 1.5 1 1 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Sec20 PF03908.8 AMD21668.1 - 0.13 11.9 2.7 0.15 11.7 0.2 2.3 2 0 0 2 2 2 0 Sec20 Pkinase PF00069.20 AMD21669.1 - 1e-66 224.7 0.1 1.3e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21669.1 - 3e-31 108.4 0.0 4.2e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21669.1 - 3.1e-09 36.1 0.0 5.7e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD21669.1 - 0.0016 17.5 0.0 0.003 16.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD21669.1 - 0.0017 18.0 0.0 0.0082 15.8 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 AMD21669.1 - 0.073 12.4 0.1 0.51 9.6 0.0 2.2 2 0 0 2 2 2 0 RIO1 family DAO PF01266.19 AMD21670.1 - 8.9e-68 228.7 0.0 3.6e-67 226.7 0.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AMD21670.1 - 6.7e-07 29.2 0.0 2.1e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 AMD21670.1 - 0.00086 18.4 0.1 0.0015 17.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 AMD21670.1 - 0.0056 16.4 0.1 0.014 15.1 0.1 1.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 AMD21670.1 - 0.0092 16.0 0.0 0.32 11.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Saccharop_dh PF03435.13 AMD21670.1 - 0.011 14.7 0.2 0.016 14.2 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Trp_halogenase PF04820.9 AMD21670.1 - 0.017 13.7 0.1 0.025 13.2 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Strep_67kDa_ant PF06100.6 AMD21670.1 - 0.021 13.1 0.2 0.032 12.5 0.1 1.2 1 0 0 1 1 1 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family Pyr_redox PF00070.22 AMD21670.1 - 0.026 14.9 0.1 0.069 13.5 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 AMD21670.1 - 0.065 13.1 0.0 0.55 10.0 0.0 2.2 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SNARE PF05739.14 AMD21671.1 - 9.2e-10 38.0 1.6 9.2e-10 38.0 1.1 3.2 3 0 0 3 3 3 1 SNARE domain Syntaxin-6_N PF09177.6 AMD21671.1 - 1.5e-07 31.7 6.6 1.9e-07 31.3 0.9 3.1 2 2 0 2 2 2 1 Syntaxin 6, N-terminal Erp_C PF06780.6 AMD21671.1 - 0.0066 16.2 0.3 0.42 10.4 0.0 2.2 2 1 0 2 2 2 1 Erp protein C-terminus FlaC_arch PF05377.6 AMD21671.1 - 0.0084 15.9 0.3 29 4.6 0.0 3.6 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) TPD52 PF04201.10 AMD21671.1 - 0.035 13.8 1.0 0.083 12.6 0.4 1.8 2 0 0 2 2 2 0 Tumour protein D52 family Mg296 PF09644.5 AMD21671.1 - 0.039 13.8 0.0 0.082 12.7 0.0 1.6 1 0 0 1 1 1 0 Mg296 protein Ribosomal_L3 PF00297.17 AMD21671.1 - 0.042 13.2 0.1 0.054 12.8 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L3 TBPIP PF07106.8 AMD21671.1 - 0.046 13.2 6.0 0.24 10.9 3.0 2.4 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Sec20 PF03908.8 AMD21671.1 - 0.046 13.4 3.5 0.072 12.8 0.3 2.6 2 1 1 3 3 3 0 Sec20 Mod_r PF07200.8 AMD21671.1 - 0.057 13.3 5.3 0.14 12.0 0.6 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Reo_sigmaC PF04582.7 AMD21671.1 - 0.083 12.0 4.3 0.23 10.5 0.3 1.8 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF724 PF05266.9 AMD21671.1 - 0.14 11.7 2.2 0.22 11.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF3373 PF11853.3 AMD21671.1 - 0.14 10.6 0.9 0.17 10.3 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Med9 PF07544.8 AMD21671.1 - 0.22 11.2 5.0 16 5.3 1.6 3.0 1 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Filament PF00038.16 AMD21671.1 - 0.22 10.9 7.1 0.36 10.2 3.5 2.2 1 1 1 2 2 2 0 Intermediate filament protein Phage_GP20 PF06810.6 AMD21671.1 - 0.27 10.6 3.9 0.14 11.6 0.6 1.9 1 1 1 2 2 2 0 Phage minor structural protein GP20 AAA_13 PF13166.1 AMD21671.1 - 0.29 9.5 4.7 1.1 7.6 3.4 1.9 1 1 0 1 1 1 0 AAA domain DUF972 PF06156.8 AMD21671.1 - 0.44 10.9 2.8 9.4 6.6 1.9 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Spc7 PF08317.6 AMD21671.1 - 0.65 8.5 9.4 0.46 9.0 1.5 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein SlyX PF04102.7 AMD21671.1 - 2.4 8.5 11.5 2.1 8.7 1.3 3.4 1 1 1 3 3 3 0 SlyX Fib_alpha PF08702.5 AMD21671.1 - 2.4 8.2 8.6 2.4 8.2 1.0 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Tup_N PF08581.5 AMD21671.1 - 7.1 6.9 7.1 5.4 7.2 0.7 2.7 2 2 0 2 2 2 0 Tup N-terminal FlxA PF14282.1 AMD21671.1 - 7.2 6.6 16.4 0.21 11.5 4.5 2.6 1 1 1 2 2 2 0 FlxA-like protein DivIC PF04977.10 AMD21671.1 - 8.1 6.0 6.8 6.5 6.3 1.7 2.7 2 1 1 3 3 2 0 Septum formation initiator Dpy-30 PF05186.8 AMD21672.1 - 8.2e-14 50.8 0.0 1e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Mito_carr PF00153.22 AMD21673.1 - 6.4e-09 35.3 0.0 0.0065 16.1 0.0 4.1 4 0 0 4 4 4 3 Mitochondrial carrier protein Reo_sigmaC PF04582.7 AMD21674.1 - 1.2 8.2 9.6 1.7 7.7 4.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein zf-DNA_Pol PF08996.5 AMD21674.1 - 1.2 8.4 6.4 0.58 9.4 0.3 2.4 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger Ribosomal_L27e PF01777.13 AMD21675.1 - 1.8e-36 124.1 5.6 2.4e-36 123.7 3.9 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 AMD21675.1 - 0.0012 18.4 1.2 0.0023 17.5 0.8 1.5 1 0 0 1 1 1 1 KOW motif DUF1512 PF07431.7 AMD21675.1 - 0.045 12.4 0.2 0.073 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) Ndr PF03096.9 AMD21675.1 - 0.11 10.9 0.0 0.15 10.5 0.0 1.4 1 0 0 1 1 1 0 Ndr family tRNA-synt_2b PF00587.20 AMD21676.1 - 2.4e-22 79.3 0.0 4.3e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 AMD21676.1 - 1.1e-06 28.6 4.8 2e-06 27.7 3.4 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.6 AMD21676.1 - 0.0068 15.1 6.6 0.01 14.4 4.6 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein COG5 PF10392.4 AMD21676.1 - 0.0093 15.9 1.5 0.016 15.1 1.0 1.3 1 0 0 1 1 1 1 Golgi transport complex subunit 5 MscS_porin PF12795.2 AMD21676.1 - 0.013 14.8 6.8 0.019 14.2 4.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain WEMBL PF05701.6 AMD21676.1 - 0.013 13.9 4.9 0.021 13.3 3.4 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light IncA PF04156.9 AMD21676.1 - 0.034 13.7 6.5 0.055 13.0 4.5 1.2 1 0 0 1 1 1 0 IncA protein DUF724 PF05266.9 AMD21676.1 - 0.037 13.6 2.0 0.061 12.9 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.4 AMD21676.1 - 0.038 12.9 4.5 0.057 12.3 3.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 CENP-K PF11802.3 AMD21676.1 - 0.042 13.0 5.4 0.067 12.4 3.8 1.2 1 0 0 1 1 1 0 Centromere-associated protein K APG6 PF04111.7 AMD21676.1 - 0.043 12.8 3.2 0.088 11.8 2.3 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Reo_sigmaC PF04582.7 AMD21676.1 - 0.062 12.4 0.2 0.092 11.9 0.1 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein HrpB7 PF09486.5 AMD21676.1 - 0.073 12.9 0.2 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF342 PF03961.8 AMD21676.1 - 0.091 11.1 3.2 0.13 10.6 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) HemX PF04375.9 AMD21676.1 - 0.11 11.0 2.7 0.17 10.4 1.8 1.2 1 0 0 1 1 1 0 HemX Mod_r PF07200.8 AMD21676.1 - 0.16 11.9 8.3 0.3 11.0 5.8 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Allexi_40kDa PF05549.6 AMD21676.1 - 0.18 11.0 1.6 0.33 10.2 0.8 1.6 2 0 0 2 2 2 0 Allexivirus 40kDa protein rRNA_proc-arch PF13234.1 AMD21676.1 - 0.23 10.5 6.5 0.37 9.8 4.5 1.2 1 0 0 1 1 1 0 rRNA-processing arch domain Tho2 PF11262.3 AMD21676.1 - 0.3 10.0 4.8 0.47 9.4 3.3 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Sec2p PF06428.6 AMD21676.1 - 0.35 10.7 6.1 0.72 9.7 4.2 1.5 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p FliD_N PF02465.13 AMD21676.1 - 0.49 10.7 7.7 1.7 9.0 0.7 2.6 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DivIC PF04977.10 AMD21676.1 - 0.64 9.5 13.2 0.24 10.8 4.1 2.3 1 1 1 2 2 2 0 Septum formation initiator M_domain PF12938.2 AMD21676.1 - 0.82 9.4 5.2 1.3 8.8 3.6 1.2 1 0 0 1 1 1 0 M domain of GW182 Macoilin PF09726.4 AMD21676.1 - 1.1 7.4 7.2 0.77 7.9 4.0 1.4 2 0 0 2 2 2 0 Transmembrane protein Med4 PF10018.4 AMD21676.1 - 8.1 5.8 9.1 9.6 5.5 2.5 2.1 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Metallophos_2 PF12850.2 AMD21677.1 - 8.6e-17 61.4 0.0 1.4e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Myc_N PF01056.13 AMD21677.1 - 0.6 9.2 6.0 0.86 8.7 4.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region S-antigen PF05756.6 AMD21677.1 - 8.6 6.4 8.3 3.4 7.7 4.0 1.6 2 0 0 2 2 2 0 S-antigen protein S-methyl_trans PF02574.11 AMD21678.1 - 4.3e-59 200.2 0.0 4.9e-59 200.1 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Acetyltransf_1 PF00583.19 AMD21679.1 - 2.1e-13 50.0 0.0 3.1e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 AMD21679.1 - 7.4e-05 22.8 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 AMD21679.1 - 0.00018 21.6 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 AMD21679.1 - 0.00043 19.9 0.0 0.00075 19.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein TRAPP PF04051.11 AMD21680.1 - 1.1e-45 154.8 0.0 1.3e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF781 PF05612.7 AMD21680.1 - 0.029 13.0 0.2 0.033 12.9 0.1 1.1 1 0 0 1 1 1 0 Mouse protein of unknown function (DUF781) Med4 PF10018.4 AMD21680.1 - 0.075 12.4 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 KAR PF15222.1 AMD21680.1 - 0.076 13.1 0.1 3.7 7.6 0.1 2.2 2 0 0 2 2 2 0 Kidney androgen-regulated Ribosomal_L23 PF00276.15 AMD21683.1 - 4.5e-22 77.7 0.0 7.6e-22 77.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 RNA_pol_Rpb2_6 PF00562.23 AMD21684.1 - 7.4e-125 416.6 0.1 1.5e-124 415.6 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 AMD21684.1 - 6.8e-68 227.5 0.1 1.1e-67 226.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 AMD21684.1 - 1.6e-51 174.4 0.0 2.8e-51 173.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 AMD21684.1 - 1.2e-30 105.5 0.1 3e-30 104.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 AMD21684.1 - 1.3e-27 95.3 0.9 2.8e-27 94.2 0.6 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 AMD21684.1 - 6.5e-22 77.0 0.1 1.8e-21 75.6 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 AMD21684.1 - 1.1e-18 66.9 0.3 2.9e-18 65.5 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ribosomal_L13 PF00572.13 AMD21685.1 - 3.5e-43 146.7 0.1 4.2e-43 146.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 SHS2_Rpb7-N PF03876.12 AMD21686.1 - 5e-17 61.7 0.0 8.2e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 AMD21686.1 - 1.7e-11 44.0 0.0 2.7e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 AMD21686.1 - 0.00016 21.8 0.0 0.00031 20.9 0.0 1.5 1 1 1 2 2 2 1 RNA polymerase III subunit Rpc25 DIT1_PvcA PF05141.7 AMD21687.1 - 1e-102 343.1 0.0 1.4e-102 342.7 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein p450 PF00067.17 AMD21688.1 - 2.4e-55 187.8 0.1 3.3e-55 187.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 RPA_interact_N PF14766.1 AMD21688.1 - 0.2 11.1 0.0 0.2 11.1 0.0 2.6 3 0 0 3 3 3 0 Replication protein A interacting N-terminal IU_nuc_hydro PF01156.14 AMD21689.1 - 3e-78 263.1 0.0 3.4e-78 263.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Utp12 PF04003.7 AMD21690.1 - 1.9e-20 72.8 2.3 4e-20 71.7 1.6 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family IceA2 PF05862.6 AMD21690.1 - 2.5e-05 23.8 0.6 7.1e-05 22.4 0.1 2.0 2 0 0 2 2 2 1 Helicobacter pylori IceA2 protein CBFD_NFYB_HMF PF00808.18 AMD21691.1 - 2.8e-14 52.9 0.8 5e-14 52.1 0.5 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 AMD21691.1 - 0.086 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 DUF2960 PF11173.3 AMD21691.1 - 0.087 13.1 0.1 0.19 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2960) IBN_N PF03810.14 AMD21692.1 - 1.8e-14 53.4 0.2 6e-14 51.7 0.2 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF445 PF04286.7 AMD21692.1 - 0.048 13.1 2.7 0.19 11.2 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Vac14_Fab1_bd PF12755.2 AMD21692.1 - 0.63 10.4 6.1 0.29 11.5 0.3 3.4 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region TetR_C_8 PF14278.1 AMD21692.1 - 0.66 10.3 10.5 24 5.4 0.1 5.2 4 0 0 4 4 4 0 Transcriptional regulator C-terminal region Glyco_transf_22 PF03901.12 AMD21693.1 - 4.8e-60 203.7 13.7 6.2e-60 203.3 9.5 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family AAA PF00004.24 AMD21694.1 - 2.6e-46 157.0 0.0 7.5e-46 155.6 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 AMD21694.1 - 2.4e-08 34.0 0.0 4.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 AMD21694.1 - 5.8e-08 32.5 0.1 2.5e-07 30.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 AMD21694.1 - 4.1e-07 30.1 0.0 1.6e-06 28.2 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 AMD21694.1 - 9.9e-07 28.9 0.4 8.3e-05 22.7 0.3 2.7 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.8 AMD21694.1 - 5.6e-05 22.1 0.0 9.8e-05 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 AMD21694.1 - 0.00018 22.3 0.1 0.00067 20.4 0.0 2.0 2 1 0 2 2 1 1 AAA domain AAA_14 PF13173.1 AMD21694.1 - 0.00028 20.8 0.0 0.00076 19.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.7 AMD21694.1 - 0.00035 19.7 0.0 0.00083 18.4 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase ruvB N-terminus NTPase_1 PF03266.10 AMD21694.1 - 0.001 18.7 0.0 0.0029 17.3 0.0 1.8 1 0 0 1 1 1 1 NTPase AAA_19 PF13245.1 AMD21694.1 - 0.0013 18.4 0.1 0.0035 17.0 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 AMD21694.1 - 0.0016 18.6 0.0 0.0032 17.6 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Zeta_toxin PF06414.7 AMD21694.1 - 0.0018 17.3 0.0 0.0033 16.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_3 PF07726.6 AMD21694.1 - 0.0023 17.5 0.0 0.0074 15.8 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 AMD21694.1 - 0.0029 17.2 0.0 0.012 15.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 AMD21694.1 - 0.0031 16.2 0.0 0.0048 15.6 0.0 1.4 1 1 0 1 1 1 1 TIP49 C-terminus AAA_24 PF13479.1 AMD21694.1 - 0.0035 16.9 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 AMD21694.1 - 0.0036 16.7 0.0 0.15 11.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.1 AMD21694.1 - 0.0038 17.0 0.0 0.0075 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 AMD21694.1 - 0.004 17.1 0.0 0.0089 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 AMD21694.1 - 0.0042 16.6 0.0 0.011 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 AMD21694.1 - 0.0044 16.6 0.1 0.061 12.9 0.0 2.4 1 1 0 2 2 2 1 NACHT domain AAA_25 PF13481.1 AMD21694.1 - 0.0044 16.4 0.9 0.11 11.8 0.1 2.3 1 1 1 2 2 2 1 AAA domain UPF0079 PF02367.12 AMD21694.1 - 0.006 16.1 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 AMD21694.1 - 0.0062 15.7 0.1 0.015 14.4 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 AMD21694.1 - 0.014 14.8 0.0 0.033 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Arch_ATPase PF01637.13 AMD21694.1 - 0.014 15.0 0.8 0.15 11.7 0.0 2.6 2 1 0 3 3 3 0 Archaeal ATPase AAA_18 PF13238.1 AMD21694.1 - 0.024 14.9 0.0 0.063 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain Bac_DnaA PF00308.13 AMD21694.1 - 0.068 12.8 0.0 0.17 11.4 0.0 1.6 1 1 0 1 1 1 0 Bacterial dnaA protein AFG1_ATPase PF03969.11 AMD21694.1 - 0.082 11.6 0.0 0.18 10.6 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase SKI PF01202.17 AMD21694.1 - 0.091 12.6 0.0 24 4.7 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase NB-ARC PF00931.17 AMD21694.1 - 0.11 11.3 0.0 0.24 10.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain She9_MDM33 PF05546.6 AMD21695.1 - 1.8e-85 285.7 11.2 1.8e-85 285.7 7.8 2.0 2 0 0 2 2 2 1 She9 / Mdm33 family PsbH PF00737.15 AMD21695.1 - 0.00093 18.7 0.4 0.0022 17.4 0.3 1.6 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein Phi-29_GP16_7 PF06720.6 AMD21695.1 - 0.046 13.3 0.7 0.12 11.9 0.5 1.8 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 TMF_DNA_bd PF12329.3 AMD21695.1 - 0.066 13.0 0.1 0.066 13.0 0.0 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Cyclin_C PF02984.14 AMD21695.1 - 0.1 12.5 4.1 0.63 9.9 0.1 2.7 2 0 0 2 2 2 0 Cyclin, C-terminal domain DUF948 PF06103.6 AMD21695.1 - 1.6 8.6 4.2 2.8 7.8 0.1 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF972 PF06156.8 AMD21695.1 - 2.4 8.5 15.2 7.1 7.0 3.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Pox_A_type_inc PF04508.7 AMD21695.1 - 5.7 6.9 11.0 2.1 8.3 1.3 4.2 3 1 0 3 3 3 0 Viral A-type inclusion protein repeat G-patch_2 PF12656.2 AMD21696.1 - 1.8e-19 69.3 1.4 2.5e-19 68.8 0.0 1.9 2 0 0 2 2 2 1 DExH-box splicing factor binding site Pur_DNA_glyco PF02245.11 AMD21696.1 - 0.098 11.7 0.1 0.23 10.5 0.1 1.6 1 0 0 1 1 1 0 Methylpurine-DNA glycosylase (MPG) Moulting_cycle PF04870.11 AMD21696.1 - 0.37 9.8 4.2 8.4 5.3 1.1 2.1 2 0 0 2 2 2 0 Moulting cycle Senescence_reg PF04520.8 AMD21696.1 - 0.66 10.4 4.7 1.5 9.3 0.2 2.1 1 1 1 2 2 2 0 Senescence regulator MDM31_MDM32 PF08118.6 AMD21697.1 - 7.1e-73 245.7 11.3 5.6e-33 114.1 0.1 4.1 2 1 2 4 4 4 4 Yeast mitochondrial distribution and morphology (MDM) proteins KH_1 PF00013.24 AMD21698.1 - 0.0003 20.3 0.4 0.00062 19.3 0.3 1.5 1 0 0 1 1 1 1 KH domain DNA_pol3_delta PF06144.8 AMD21699.1 - 0.019 14.4 0.3 0.019 14.4 0.2 2.8 4 0 0 4 4 4 0 DNA polymerase III, delta subunit AAA PF00004.24 AMD21699.1 - 0.024 14.8 0.5 0.1 12.7 0.0 2.3 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) TFIID-18kDa PF02269.11 AMD21700.1 - 1.3e-35 121.0 0.6 2.6e-35 120.0 0.1 1.7 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit DUF3683 PF12447.3 AMD21700.1 - 0.027 14.2 1.0 0.046 13.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3683) TPK_catalytic PF04263.11 AMD21701.1 - 9.2e-19 67.2 0.0 3e-14 52.6 0.0 2.5 1 1 2 3 3 3 2 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 AMD21701.1 - 4.2e-13 48.8 0.3 8.8e-13 47.7 0.2 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain DUF1140 PF06600.6 AMD21702.1 - 0.084 13.0 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1140) Clat_adaptor_s PF01217.15 AMD21703.1 - 1.9e-53 180.0 0.7 2.2e-53 179.8 0.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TP_methylase PF00590.15 AMD21704.1 - 1.2e-23 83.9 0.0 1.8e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.1 AMD21704.1 - 0.019 14.7 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Mpv17_PMP22 PF04117.7 AMD21707.1 - 1.7e-28 98.0 3.4 1.7e-28 98.0 2.4 2.2 2 0 0 2 2 2 2 Mpv17 / PMP22 family ABC1 PF03109.11 AMD21708.1 - 4.5e-30 104.0 0.0 1.1e-29 102.8 0.0 1.7 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.17 AMD21708.1 - 4.1e-05 23.0 0.1 0.00023 20.5 0.0 2.2 3 0 0 3 3 3 1 RIO1 family m04gp34like PF12216.3 AMD21708.1 - 0.75 9.0 6.1 3.8 6.7 0.3 2.9 3 0 0 3 3 3 0 Immune evasion protein Atg14 PF10186.4 AMD21709.1 - 0.0009 18.2 5.7 0.00092 18.2 3.9 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 MAD PF05557.8 AMD21709.1 - 0.0053 14.9 14.2 0.0058 14.7 9.9 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Glyco_hydro_53 PF07745.8 AMD21709.1 - 0.042 12.6 0.4 0.052 12.3 0.3 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 hDGE_amylase PF14701.1 AMD21709.1 - 0.043 12.7 2.8 0.057 12.3 1.9 1.2 1 0 0 1 1 1 0 glucanotransferase domain of human glycogen debranching enzyme DUF603 PF04645.7 AMD21709.1 - 0.079 12.8 4.5 0.11 12.4 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF603 APG6 PF04111.7 AMD21709.1 - 0.11 11.5 16.8 0.14 11.1 11.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 bZIP_1 PF00170.16 AMD21709.1 - 0.36 10.8 17.9 1.1 9.2 3.3 3.4 1 1 2 3 3 3 0 bZIP transcription factor NTPase_1 PF03266.10 AMD21709.1 - 0.61 9.7 3.5 0.95 9.1 2.4 1.3 1 0 0 1 1 1 0 NTPase DUF1640 PF07798.6 AMD21709.1 - 2.7 8.0 15.5 4.1 7.4 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) G-gamma PF00631.17 AMD21709.1 - 2.9 7.7 6.9 0.38 10.5 0.2 2.6 2 1 0 2 2 2 0 GGL domain TBPIP PF07106.8 AMD21709.1 - 4 6.9 16.8 1.2 8.6 8.8 1.9 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) V_ATPase_I PF01496.14 AMD21709.1 - 4.2 5.1 8.8 5 4.8 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.7 AMD21709.1 - 4.5 7.0 20.3 16 5.2 14.0 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein SPX PF03105.14 AMD21709.1 - 6 6.5 7.0 8.2 6.1 4.8 1.3 1 0 0 1 1 1 0 SPX domain Fungal_trans PF04082.13 AMD21710.1 - 5.2e-09 35.3 3.8 5.2e-09 35.3 2.6 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD21710.1 - 1.6e-07 31.0 8.6 3.3e-07 30.0 6.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_8 PF08022.7 AMD21711.1 - 2.4e-13 49.8 0.0 5.6e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 AMD21711.1 - 1.7e-10 41.0 13.5 2e-10 40.8 7.5 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 AMD21711.1 - 5e-09 36.2 0.0 1.4e-08 34.8 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain GWT1 PF06423.7 AMD21711.1 - 0.14 12.2 0.2 0.14 12.2 0.1 3.4 1 1 2 3 3 3 0 GWT1 DUF4131 PF13567.1 AMD21711.1 - 2.6 7.4 6.8 3.1 7.1 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Vezatin PF12632.2 AMD21712.1 - 2.6e-29 102.0 11.6 2.6e-29 102.0 8.0 2.1 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes UDPGP PF01704.13 AMD21713.1 - 2e-51 174.8 0.0 2.6e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 AMD21713.1 - 0.037 14.1 0.0 0.097 12.7 0.0 1.9 1 1 0 1 1 1 0 MobA-like NTP transferase domain Hydrolase PF00702.21 AMD21714.1 - 1.9e-19 70.9 0.0 2.2e-17 64.2 0.0 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 AMD21714.1 - 3.8e-17 62.0 0.0 3.8e-17 62.0 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 AMD21714.1 - 9.4e-14 51.1 0.0 3.3e-13 49.3 0.0 2.0 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 AMD21714.1 - 1.2e-12 48.3 0.1 2.7e-11 44.0 0.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AMD21714.1 - 0.005 16.4 0.1 0.02 14.4 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DnaJ PF00226.26 AMD21715.1 - 9.2e-26 89.3 1.6 1.7e-25 88.5 1.1 1.4 1 0 0 1 1 1 1 DnaJ domain DNA_pol_B PF00136.16 AMD21716.1 - 1.3e-133 446.2 1.0 1.7e-133 445.8 0.7 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 AMD21716.1 - 2.2e-85 286.3 0.1 3.6e-85 285.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 AMD21716.1 - 9e-23 80.0 4.3 9e-23 80.0 3.0 1.8 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.4 AMD21716.1 - 2.6e-05 23.8 0.0 7.1e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 AMD21716.1 - 0.0009 19.0 0.2 0.0039 17.0 0.1 2.1 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_2 PF03175.8 AMD21716.1 - 0.004 15.8 7.8 0.0076 14.9 0.8 2.7 3 0 0 3 3 3 2 DNA polymerase type B, organellar and viral Pkinase PF00069.20 AMD21717.1 - 4.1e-69 232.6 0.0 5e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21717.1 - 8.9e-34 116.7 0.0 1.2e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 AMD21717.1 - 2.2e-17 62.8 0.3 4.7e-17 61.8 0.2 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.1 AMD21717.1 - 0.0011 17.9 0.7 3 6.7 0.1 3.1 2 1 0 3 3 3 2 Kinase-like Kdo PF06293.9 AMD21717.1 - 0.0027 16.7 0.4 0.0041 16.1 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 AMD21717.1 - 0.0097 15.2 0.4 0.018 14.3 0.3 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL ATG16 PF08614.6 AMD21719.1 - 2.9e-21 76.2 8.8 2.9e-20 72.9 5.8 1.9 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.3 AMD21719.1 - 0.00049 19.8 1.0 0.00065 19.4 0.7 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding DUF641 PF04859.7 AMD21719.1 - 0.055 13.2 0.6 0.1 12.3 0.3 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) ArsA_ATPase PF02374.10 AMD21720.1 - 6.4e-115 383.3 0.2 7.4e-115 383.1 0.1 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 AMD21720.1 - 2.7e-11 43.2 0.2 6.6e-11 41.9 0.1 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.13 AMD21720.1 - 0.00041 19.6 0.0 0.00083 18.6 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_31 PF13614.1 AMD21720.1 - 0.015 15.2 0.0 0.042 13.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 AMD21720.1 - 0.052 12.9 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 AMD21720.1 - 0.13 11.2 0.0 0.38 9.8 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AATF-Che1 PF13339.1 AMD21721.1 - 0.0033 17.5 3.5 0.0033 17.5 2.4 3.7 1 1 2 3 3 3 1 Apoptosis antagonizing transcription factor DUF848 PF05852.6 AMD21721.1 - 0.0097 15.7 4.2 0.0097 15.7 2.9 3.0 3 1 1 4 4 4 1 Gammaherpesvirus protein of unknown function (DUF848) Striatin PF08232.7 AMD21721.1 - 0.02 15.2 4.5 0.02 15.2 3.1 3.7 1 1 0 2 2 2 0 Striatin family DivIC PF04977.10 AMD21721.1 - 0.027 13.9 1.9 0.027 13.9 1.3 3.7 3 1 1 4 4 4 0 Septum formation initiator RsbRD_N PF14361.1 AMD21721.1 - 0.033 14.6 0.8 0.084 13.3 0.6 1.7 1 0 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain Pox_A_type_inc PF04508.7 AMD21721.1 - 0.1 12.4 5.0 0.72 9.7 0.0 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat IncA PF04156.9 AMD21721.1 - 3.3 7.2 13.7 3.6 7.1 8.0 2.1 1 1 0 1 1 1 0 IncA protein SlyX PF04102.7 AMD21721.1 - 5 7.5 10.5 2.5 8.5 3.3 3.0 2 1 1 3 3 3 0 SlyX TSC22 PF01166.13 AMD21721.1 - 6.6 6.7 8.5 11 6.0 0.0 3.0 3 0 0 3 3 3 0 TSC-22/dip/bun family Ribosomal_S8 PF00410.14 AMD21722.1 - 1.8e-18 66.5 0.0 2.5e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 TPT PF03151.11 AMD21723.1 - 0.03 13.9 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Triose-phosphate Transporter family DUF3398 PF11878.3 AMD21723.1 - 0.041 13.7 0.1 0.077 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) DUF387 PF04079.11 AMD21723.1 - 0.083 12.2 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative transcriptional regulators (Ypuh-like) zf-met PF12874.2 AMD21724.1 - 3.5e-06 26.9 1.2 3.5e-06 26.9 0.8 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD21724.1 - 5.5e-05 23.1 1.3 0.00014 21.8 0.9 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding SRP-alpha_N PF04086.8 AMD21724.1 - 0.00046 19.6 3.5 0.00094 18.6 2.4 1.4 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal zf-C2H2_4 PF13894.1 AMD21724.1 - 0.088 13.1 0.9 0.25 11.7 0.6 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AMD21724.1 - 0.16 11.9 0.7 0.35 10.8 0.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-DBF PF07535.7 AMD21724.1 - 1.4 8.6 7.6 0.15 11.7 0.7 2.6 3 0 0 3 3 3 0 DBF zinc finger PCI PF01399.22 AMD21725.1 - 2.3e-17 63.2 0.0 8.9e-17 61.3 0.0 2.1 1 0 0 1 1 1 1 PCI domain TPR_16 PF13432.1 AMD21725.1 - 2.3e-05 24.9 4.2 0.071 13.7 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 AMD21725.1 - 0.0051 17.1 6.4 0.65 10.3 0.4 3.8 4 1 0 4 4 4 2 Tetratricopeptide repeat PCI_Csn8 PF10075.4 AMD21725.1 - 0.042 13.6 0.8 0.083 12.6 0.6 1.5 1 0 0 1 1 1 0 COP9 signalosome, subunit CSN8 DDRGK PF09756.4 AMD21725.1 - 0.11 11.9 1.5 0.4 10.0 0.0 2.5 2 1 1 3 3 3 0 DDRGK domain TPR_2 PF07719.12 AMD21725.1 - 0.32 11.0 7.8 4.6 7.3 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 AMD21725.1 - 2.7 8.1 20.0 0.38 10.9 0.6 4.2 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PMT PF02366.13 AMD21726.1 - 3.9e-79 265.4 20.4 8.5e-79 264.3 14.1 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 AMD21726.1 - 3.6e-55 186.4 1.7 5.9e-55 185.7 1.2 1.3 1 0 0 1 1 1 1 MIR domain Glug PF07581.7 AMD21726.1 - 3.1 8.1 7.4 0.5 10.6 2.0 2.1 2 0 0 2 2 2 0 The GLUG motif MFS_1 PF07690.11 AMD21727.1 - 3.4e-15 55.6 15.1 5.9e-15 54.8 10.5 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.8 AMD21727.1 - 1.2e-12 47.6 2.3 1.2e-12 47.6 1.6 3.0 4 0 0 4 4 4 1 Nodulin-like SRP14 PF02290.10 AMD21728.1 - 3.1e-17 62.2 0.0 5.6e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle 14kD protein UBX PF00789.15 AMD21729.1 - 7.8e-14 51.4 0.0 2e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 UBX domain Prenyltrans PF00432.16 AMD21730.1 - 3.7e-36 122.3 9.8 2.2e-12 46.2 1.2 6.3 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 AMD21730.1 - 6.8e-21 74.7 0.0 9.4e-13 48.5 0.0 3.7 2 1 2 4 4 4 2 Prenyltransferase-like Prenyltrans_1 PF13243.1 AMD21730.1 - 0.0059 16.6 0.0 0.21 11.5 0.0 3.0 1 1 1 2 2 2 2 Prenyltransferase-like Crl PF07417.7 AMD21730.1 - 0.1 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator Crl Lenti_VIF_2 PF07401.7 AMD21731.1 - 0.065 12.3 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Bovine Lentivirus VIF protein DUF2418 PF10332.4 AMD21732.1 - 1e-21 77.0 0.5 1e-21 77.0 0.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) Mt_ATP-synt_B PF05405.9 AMD21732.1 - 0.092 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Nup35_RRM PF05172.8 AMD21733.1 - 1.1e-33 114.9 0.0 2.4e-33 113.8 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.1 AMD21733.1 - 0.00062 19.4 0.0 0.006 16.3 0.0 2.2 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_6 PF14259.1 AMD21733.1 - 0.039 13.9 0.0 1 9.3 0.0 2.9 2 1 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) MAS20 PF02064.10 AMD21733.1 - 0.11 12.4 0.5 0.23 11.3 0.1 1.9 2 0 0 2 2 2 0 MAS20 protein import receptor LUC7 PF03194.10 AMD21734.1 - 1.5e-67 227.8 7.9 1.8e-67 227.5 5.5 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Rho_Binding PF08912.6 AMD21734.1 - 0.013 15.7 1.4 0.028 14.6 0.2 2.2 2 0 0 2 2 2 0 Rho Binding FlaC_arch PF05377.6 AMD21734.1 - 0.069 13.0 2.1 0.34 10.8 0.8 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) FlgN PF05130.7 AMD21734.1 - 0.071 13.3 1.4 0.17 12.1 0.6 1.8 2 0 0 2 2 2 0 FlgN protein DUF4200 PF13863.1 AMD21734.1 - 0.21 11.5 6.2 1.3 8.9 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Peptidase_S24 PF00717.18 AMD21736.1 - 1.4e-07 30.9 0.1 1.8e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.4 AMD21736.1 - 0.0012 18.3 0.0 0.0022 17.5 0.0 1.4 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Ribophorin_II PF05817.9 AMD21737.1 - 6.4e-08 31.2 0.9 7.4e-08 31.0 0.6 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II PilO PF04350.8 AMD21738.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Pilus assembly protein, PilO DUF925 PF06042.6 AMD21739.1 - 0.11 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF925) WD40 PF00400.27 AMD21740.1 - 1.3e-29 100.9 0.0 1.2e-07 31.2 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 AMD21740.1 - 6.3e-06 26.0 0.1 0.00025 20.7 0.0 2.7 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Gmad1 PF10647.4 AMD21740.1 - 0.00059 19.3 0.1 0.0017 17.7 0.0 1.7 2 0 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain Cytochrom_D1 PF02239.11 AMD21740.1 - 0.019 13.2 0.3 0.19 9.9 0.1 2.5 1 1 2 4 4 4 0 Cytochrome D1 heme domain 4F5 PF04419.9 AMD21741.1 - 8.7e-10 39.1 10.4 8.7e-10 39.1 7.2 2.2 2 0 0 2 2 2 1 4F5 protein family PARP PF00644.15 AMD21741.1 - 0.34 10.3 2.0 0.4 10.0 1.4 1.0 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain Peptidase_M49 PF03571.10 AMD21741.1 - 0.39 8.7 2.5 0.44 8.5 1.7 1.0 1 0 0 1 1 1 0 Peptidase family M49 COG5 PF10392.4 AMD21741.1 - 0.42 10.5 4.7 0.48 10.3 3.3 1.1 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DDRGK PF09756.4 AMD21741.1 - 9.8 5.5 15.2 11 5.3 10.5 1.0 1 0 0 1 1 1 0 DDRGK domain Pyr_redox_2 PF07992.9 AMD21742.1 - 7.2e-26 91.3 0.0 4.5e-16 59.3 0.0 4.0 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 AMD21742.1 - 2.3e-12 47.1 0.0 1.9e-11 44.2 0.0 2.6 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 AMD21742.1 - 0.00015 21.9 0.1 0.21 11.6 0.0 3.8 4 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase DUF724 PF05266.9 AMD21742.1 - 0.021 14.4 1.2 0.035 13.7 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HTH_psq PF05225.11 AMD21743.1 - 0.0028 17.1 0.1 0.019 14.4 0.0 2.3 2 0 0 2 2 2 1 helix-turn-helix, Psq domain HTH_Tnp_Tc5 PF03221.11 AMD21743.1 - 0.036 13.8 0.0 0.14 12.0 0.0 2.1 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DUF455 PF04305.9 AMD21743.1 - 0.053 12.7 0.1 0.11 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF455) DEAD PF00270.24 AMD21744.1 - 2.5e-34 118.2 0.3 5.8e-34 117.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD21744.1 - 4.2e-24 84.2 0.0 1.3e-22 79.4 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD21744.1 - 1e-05 25.4 0.1 2.5e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 AMD21744.1 - 0.037 13.1 0.0 0.08 11.9 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Ribosomal_S9 PF00380.14 AMD21746.1 - 7e-39 132.8 0.5 7.9e-39 132.6 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Glyco_trans_1_3 PF13528.1 AMD21746.1 - 0.084 12.0 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 Ribosomal_L13e PF01294.13 AMD21747.1 - 2.3e-71 238.9 4.9 3e-71 238.5 3.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_60s PF00428.14 AMD21748.1 - 4.6e-22 78.2 12.5 5.7e-22 77.9 8.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3245 PF11595.3 AMD21748.1 - 0.073 13.3 0.1 0.088 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) DUF1420 PF07220.6 AMD21748.1 - 0.13 10.5 0.0 0.14 10.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1420) zf-C3HC4_2 PF13923.1 AMD21749.1 - 3.4 7.7 8.9 14 5.7 6.2 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPP_enzyme_N PF02776.13 AMD21750.1 - 2e-33 115.3 0.0 3e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 AMD21750.1 - 4.7e-23 81.4 0.0 1e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 AMD21750.1 - 1.2e-11 44.4 0.0 2.6e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Pkinase PF00069.20 AMD21751.1 - 7.1e-61 205.6 0.0 8.5e-61 205.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21751.1 - 2.2e-25 89.2 0.0 3.4e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AMD21751.1 - 0.00044 20.0 0.2 0.004 16.9 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 AMD21751.1 - 0.00091 18.2 0.0 0.015 14.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.15 AMD21751.1 - 0.0041 16.7 0.7 0.018 14.6 0.5 1.9 1 1 0 1 1 1 1 Choline/ethanolamine kinase Ldh_1_N PF00056.18 AMD21752.1 - 1.4e-41 141.6 0.2 2.3e-41 140.9 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 AMD21752.1 - 1.7e-29 102.7 0.0 2.8e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 AMD21752.1 - 0.0019 16.9 0.0 0.0028 16.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Arf PF00025.16 AMD21753.1 - 2.7e-42 143.9 0.0 3.1e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 AMD21753.1 - 6.3e-11 41.5 1.1 4e-06 25.7 0.0 2.9 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 AMD21753.1 - 1.7e-09 37.1 0.0 2e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 AMD21753.1 - 5.6e-06 25.9 0.0 0.00024 20.6 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.17 AMD21753.1 - 1.6e-05 24.3 0.0 2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD21753.1 - 7.4e-05 23.2 0.0 0.00019 21.9 0.0 1.7 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 AMD21753.1 - 0.00028 20.8 0.0 0.00041 20.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.14 AMD21753.1 - 0.00087 18.7 0.1 0.11 11.9 0.0 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.5 AMD21753.1 - 0.066 12.4 0.0 0.1 11.8 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DRMBL PF07522.9 AMD21754.1 - 7.5e-21 74.2 0.1 1.5e-20 73.2 0.1 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 AMD21754.1 - 4.3e-10 39.4 0.2 8.2e-10 38.5 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF2457 PF10446.4 AMD21754.1 - 2.4 6.7 10.4 3.4 6.2 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) GATA PF00320.22 AMD21755.1 - 3.2e-14 51.9 2.8 7e-14 50.8 2.0 1.6 1 0 0 1 1 1 1 GATA zinc finger CLTH PF10607.4 AMD21756.1 - 1.7e-21 76.4 3.0 1.7e-21 76.4 2.1 1.9 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Meiotic_rec114 PF03525.9 AMD21758.1 - 4.5e-17 61.5 4.0 9.6e-17 60.4 2.8 1.7 1 1 0 1 1 1 1 Meiotic recombination protein rec114 DUF814 PF05670.8 AMD21759.1 - 3.1e-18 65.4 0.0 5.6e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Glyco_hydro_17 PF00332.13 AMD21759.1 - 0.073 12.0 0.3 0.1 11.6 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 DUF2452 PF10504.4 AMD21759.1 - 0.077 12.2 1.0 0.12 11.6 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) Retrotrans_gag PF03732.12 AMD21759.1 - 0.086 12.9 1.3 0.19 11.7 0.9 1.5 1 0 0 1 1 1 0 Retrotransposon gag protein CAF1C_H4-bd PF12265.3 AMD21760.1 - 2.7e-17 62.4 0.0 8.3e-17 60.8 0.0 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.27 AMD21760.1 - 3.4e-16 58.4 9.6 2.4e-06 27.1 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Saw1 PF11561.3 AMD21760.1 - 0.027 13.8 1.8 0.068 12.5 1.3 1.7 1 0 0 1 1 1 0 Single strand annealing-weakened 1 FLO_LFY PF01698.11 AMD21760.1 - 0.04 12.7 0.0 0.04 12.7 0.0 1.8 3 0 0 3 3 3 0 Floricaula / Leafy protein TEX19 PF15553.1 AMD21760.1 - 2.8 7.7 10.1 0.065 13.1 0.4 2.6 3 0 0 3 3 3 0 Testis-expressed protein 19 Spt5_N PF11942.3 AMD21760.1 - 2.8 8.6 19.7 1.5 9.5 3.2 2.8 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal RIC1 PF07064.8 AMD21761.1 - 1.5e-09 37.6 0.0 8e-09 35.3 0.0 2.2 1 1 0 1 1 1 1 RIC1 COX6B PF02297.12 AMD21762.1 - 5.6e-21 74.3 5.0 6.6e-21 74.1 3.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Somatostatin PF03002.10 AMD21762.1 - 0.029 14.0 0.2 0.066 12.8 0.2 1.6 1 0 0 1 1 1 0 Somatostatin/Cortistatin family APOBEC_C PF05240.9 AMD21762.1 - 0.083 12.3 0.4 0.15 11.5 0.2 1.4 1 0 0 1 1 1 0 APOBEC-like C-terminal domain UPF0203 PF05254.7 AMD21762.1 - 0.42 10.4 2.8 0.49 10.2 0.8 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) HAD_2 PF13419.1 AMD21763.1 - 3.7e-17 63.1 0.0 6e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AMD21763.1 - 1.1e-05 24.9 0.0 2.3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 AMD21763.1 - 0.1 13.0 0.0 0.21 11.9 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Nramp PF01566.13 AMD21765.1 - 1.3e-92 310.3 19.3 2.1e-92 309.7 13.4 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Bromodomain PF00439.20 AMD21766.1 - 0.0014 18.4 0.0 0.0043 16.9 0.0 1.9 1 0 0 1 1 1 1 Bromodomain ELM2 PF01448.19 AMD21766.1 - 0.13 12.9 1.7 0.22 12.2 0.2 2.2 2 0 0 2 2 2 0 ELM2 domain HA2 PF04408.18 AMD21767.1 - 9.7e-23 80.1 0.0 9.7e-23 80.1 0.0 2.6 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 AMD21767.1 - 1.3e-14 53.7 0.1 2.8e-13 49.5 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 AMD21767.1 - 1.1e-13 50.9 0.0 3.9e-13 49.2 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 AMD21767.1 - 2.9e-09 36.6 0.0 7.9e-09 35.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 AMD21767.1 - 2.5e-06 27.6 0.1 1e-05 25.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 AMD21767.1 - 0.0079 15.3 0.2 0.0079 15.3 0.1 2.6 2 1 1 3 3 3 1 KaiC T2SE PF00437.15 AMD21767.1 - 0.013 14.4 0.0 0.03 13.2 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Yae1_N PF09811.4 AMD21767.1 - 0.33 10.5 1.7 0.59 9.7 1.2 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal MOZ_SAS PF01853.13 AMD21768.1 - 2.8e-61 206.0 1.0 4.5e-61 205.3 0.7 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-C2H2 PF00096.21 AMD21768.1 - 0.027 14.7 1.5 0.067 13.5 0.3 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type SNF2_N PF00176.18 AMD21769.1 - 4.3e-70 235.8 0.0 7.7e-70 235.0 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD21769.1 - 1.1e-11 44.4 0.0 2.5e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HIRAN PF08797.6 AMD21769.1 - 1.4e-10 41.0 0.0 3.6e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 HIRAN domain zf-RING_2 PF13639.1 AMD21769.1 - 2.7e-07 30.2 11.0 5.4e-07 29.3 7.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 AMD21769.1 - 9.1e-07 28.8 12.7 1.8e-06 27.8 8.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD21769.1 - 2.3e-05 23.9 13.2 4.8e-05 22.9 9.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD21769.1 - 8.6e-05 22.1 12.2 0.00018 21.1 8.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 AMD21769.1 - 0.008 16.2 4.0 0.021 14.9 2.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 AMD21769.1 - 0.024 14.4 1.9 0.051 13.4 1.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.1 AMD21769.1 - 0.69 9.7 4.9 1.7 8.4 3.4 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 AMD21769.1 - 1.4 8.8 12.1 3.3 7.6 8.4 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 AMD21769.1 - 2.3 7.7 8.3 6.7 6.3 5.8 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit NICE-3 PF07406.6 AMD21770.1 - 0.08 12.4 0.7 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 NICE-3 protein MIF4G_like PF09088.6 AMD21771.1 - 1.6e-58 197.2 1.0 3.5e-58 196.1 0.7 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.6 AMD21771.1 - 2.1e-55 187.6 3.4 2.1e-55 187.6 2.3 1.7 2 0 0 2 2 2 1 MIF4G like MIF4G PF02854.14 AMD21771.1 - 1.5e-12 47.3 0.4 1.5e-12 47.3 0.2 2.5 3 0 0 3 3 3 1 MIF4G domain Collagen PF01391.13 AMD21772.1 - 0.029 13.9 17.6 0.13 11.8 9.3 3.0 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) Pkr1 PF08636.5 AMD21773.1 - 8.3e-33 112.2 7.1 9.5e-33 112.1 4.9 1.0 1 0 0 1 1 1 1 ER protein Pkr1 CstA PF02554.9 AMD21773.1 - 0.014 14.0 0.4 0.014 14.0 0.2 1.0 1 0 0 1 1 1 0 Carbon starvation protein CstA DUF1772 PF08592.6 AMD21773.1 - 0.023 14.4 0.5 0.026 14.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Peptidase_A22B PF04258.8 AMD21773.1 - 0.024 14.0 0.6 0.026 13.9 0.4 1.1 1 0 0 1 1 1 0 Signal peptide peptidase DUF3487 PF11990.3 AMD21773.1 - 0.066 12.6 1.2 0.081 12.3 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) DUF4131 PF13567.1 AMD21773.1 - 0.1 12.0 0.2 0.11 11.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3985 PF13153.1 AMD21773.1 - 0.61 9.9 3.9 0.92 9.3 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3985) ATP-synt_8 PF00895.15 AMD21773.1 - 1.1 9.4 4.3 55 4.0 3.0 2.3 1 1 0 1 1 1 0 ATP synthase protein 8 HemY_N PF07219.8 AMD21773.1 - 9.8 5.7 6.9 1.6 8.2 0.4 2.0 1 1 1 2 2 2 0 HemY protein N-terminus CDK2AP PF09806.4 AMD21774.1 - 2.3 8.3 10.8 3.1 7.9 7.5 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Ribosomal_L15e PF00827.12 AMD21776.1 - 2e-90 301.4 14.3 2.3e-90 301.2 9.9 1.0 1 0 0 1 1 1 1 Ribosomal L15 AICARFT_IMPCHas PF01808.13 AMD21777.1 - 2.5e-120 401.3 0.0 3.5e-120 400.8 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 AMD21777.1 - 1.1e-23 82.9 0.2 2.7e-23 81.7 0.0 1.7 2 0 0 2 2 2 1 MGS-like domain zf-C3HC4_3 PF13920.1 AMD21778.1 - 3.7e-07 29.7 13.2 7.6e-07 28.7 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) YL1 PF05764.8 AMD21778.1 - 0.65 9.5 7.2 1.2 8.7 5.0 1.3 1 0 0 1 1 1 0 YL1 nuclear protein zf-C3HC4_2 PF13923.1 AMD21778.1 - 7.6 6.6 15.7 22 5.1 10.8 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Aminotran_1_2 PF00155.16 AMD21779.1 - 8.2e-81 271.7 0.0 9.3e-81 271.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SNARE PF05739.14 AMD21780.1 - 6.4e-18 64.2 3.4 6.4e-18 64.2 2.4 3.0 4 0 0 4 4 4 1 SNARE domain Syntaxin PF00804.20 AMD21780.1 - 3e-17 62.6 3.1 3e-17 62.6 2.2 2.6 2 1 0 2 2 2 1 Syntaxin Sed5p PF11416.3 AMD21780.1 - 1.8e-13 49.6 1.7 3e-12 45.7 0.0 2.5 2 0 0 2 2 2 1 Integral membrane protein Sed5p DIL PF01843.14 AMD21780.1 - 0.00014 21.7 0.1 0.00041 20.1 0.1 1.8 1 0 0 1 1 1 1 DIL domain Syntaxin-18_N PF10496.4 AMD21780.1 - 0.0002 21.1 0.4 0.00072 19.3 0.0 2.2 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus MCPsignal PF00015.16 AMD21780.1 - 0.00027 20.5 7.5 0.0024 17.4 0.6 2.6 2 1 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain Vac_Fusion PF02346.11 AMD21780.1 - 0.026 13.9 0.4 2.8 7.4 0.0 2.8 2 0 0 2 2 2 0 Chordopoxvirus fusion protein AF0941-like PF14591.1 AMD21780.1 - 0.043 13.8 3.1 1.2 9.2 0.0 3.0 3 0 0 3 3 3 0 AF0941-like Glutaredoxin2_C PF04399.8 AMD21780.1 - 0.049 13.2 7.3 0.13 11.8 0.3 3.4 4 1 0 4 4 4 0 Glutaredoxin 2, C terminal domain DUF1664 PF07889.7 AMD21780.1 - 0.1 12.3 7.4 0.6 9.9 0.3 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.6 AMD21780.1 - 0.14 12.5 6.4 0.67 10.3 0.2 3.2 2 2 0 2 2 2 0 Syntaxin 6, N-terminal Prominin PF05478.6 AMD21780.1 - 0.6 7.5 5.0 0.19 9.2 0.2 2.0 2 0 0 2 2 2 0 Prominin DUF745 PF05335.8 AMD21780.1 - 0.6 9.5 10.4 0.73 9.3 1.5 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Cluap1 PF10234.4 AMD21780.1 - 0.62 9.2 8.3 0.26 10.4 1.4 2.3 2 0 0 2 2 2 0 Clusterin-associated protein-1 NPV_P10 PF05531.7 AMD21780.1 - 0.7 10.1 8.2 5.4 7.3 0.5 3.4 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 AMD21780.1 - 0.73 9.7 4.6 5.2 7.0 0.1 3.6 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) V-SNARE PF05008.10 AMD21780.1 - 1.7 8.8 7.2 1.3 9.2 0.4 3.4 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Snf7 PF03357.16 AMD21781.1 - 4.7e-52 175.8 12.6 4.7e-52 175.8 8.7 1.9 2 0 0 2 2 2 1 Snf7 PspA_IM30 PF04012.7 AMD21781.1 - 0.014 14.7 15.4 0.044 13.1 10.7 2.0 1 1 0 1 1 1 0 PspA/IM30 family Cupin_8 PF13621.1 AMD21781.1 - 0.31 10.5 2.0 0.45 9.9 1.3 1.3 1 1 0 1 1 1 0 Cupin-like domain Syntaxin-6_N PF09177.6 AMD21781.1 - 0.36 11.2 3.0 1 9.8 0.8 2.4 1 1 0 2 2 2 0 Syntaxin 6, N-terminal Snapin_Pallidin PF14712.1 AMD21781.1 - 3.4 8.0 16.2 0.37 11.1 5.7 2.8 2 1 2 4 4 4 0 Snapin/Pallidin CHASE3 PF05227.8 AMD21781.1 - 3.6 7.2 11.8 0.22 11.2 4.2 1.8 2 0 0 2 2 2 0 CHASE3 domain TBPIP PF07106.8 AMD21781.1 - 5 6.6 14.6 0.86 9.1 2.0 3.1 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HALZ PF02183.13 AMD21782.1 - 0.0023 17.6 1.8 0.0054 16.4 1.2 1.7 1 0 0 1 1 1 1 Homeobox associated leucine zipper Nnf1 PF03980.9 AMD21782.1 - 0.027 14.4 0.8 0.44 10.5 0.1 2.6 2 1 0 2 2 2 0 Nnf1 DivIC PF04977.10 AMD21782.1 - 0.078 12.4 0.8 0.16 11.4 0.6 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_2 PF07716.10 AMD21782.1 - 0.13 12.0 0.6 0.32 10.8 0.4 1.7 1 0 0 1 1 1 0 Basic region leucine zipper Sdh_cyt PF01127.17 AMD21783.1 - 1.5e-26 92.5 2.4 2e-26 92.1 1.7 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Pkinase PF00069.20 AMD21784.1 - 4.4e-74 248.9 0.0 5.7e-74 248.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21784.1 - 2.8e-34 118.3 0.0 3.7e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21784.1 - 4e-05 22.7 0.0 9.4e-05 21.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 AMD21784.1 - 0.017 14.8 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 AMD21784.1 - 0.052 12.3 0.1 0.11 11.3 0.0 1.5 1 1 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.9 AMD21784.1 - 0.073 12.1 0.2 0.21 10.6 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DASH_Hsk3 PF08227.6 AMD21785.1 - 1.8e-18 66.4 3.9 2.3e-18 66.0 2.7 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Spc24 PF08286.6 AMD21786.1 - 3.2e-22 78.4 0.3 3.2e-22 78.4 0.2 2.2 1 1 0 2 2 2 1 Spc24 subunit of Ndc80 AIP3 PF03915.8 AMD21786.1 - 0.014 14.3 8.6 0.018 13.9 6.0 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 NdhM PF10664.4 AMD21786.1 - 0.098 12.5 0.8 0.28 11.1 0.4 1.9 1 1 1 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M DUF342 PF03961.8 AMD21786.1 - 0.49 8.7 4.9 0.59 8.4 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF16 PF01519.11 AMD21786.1 - 0.54 10.5 6.8 0.96 9.7 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF4613 PF15390.1 AMD21786.1 - 0.79 7.8 9.7 0.93 7.5 6.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) BssS PF13991.1 AMD21786.1 - 1 9.1 3.9 0.57 9.9 0.8 2.0 1 1 1 2 2 2 0 BssS protein family Seryl_tRNA_N PF02403.17 AMD21786.1 - 1.3 9.0 12.4 53 3.9 8.6 2.2 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Exonuc_VII_L PF02601.10 AMD21786.1 - 1.5 7.9 9.9 1.9 7.6 6.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_S46 PF10459.4 AMD21786.1 - 2.4 6.4 5.2 3 6.1 3.6 1.1 1 0 0 1 1 1 0 Peptidase S46 CCDC-167 PF15188.1 AMD21786.1 - 2.5 8.0 11.2 19 5.2 7.8 2.2 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF1690 PF07956.6 AMD21786.1 - 2.9 7.8 13.8 4.3 7.3 9.6 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) CorA PF01544.13 AMD21786.1 - 3 6.7 9.5 4 6.3 6.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF572 PF04502.8 AMD21786.1 - 4.1 6.5 8.2 4.9 6.2 5.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) COG2 PF06148.6 AMD21786.1 - 7.4 6.4 11.0 0.58 10.0 1.0 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 L31 PF09784.4 AMD21787.1 - 2.2e-41 140.1 2.8 5.2e-41 138.9 2.0 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L31 Cmc1 PF08583.5 AMD21788.1 - 3.5e-17 61.9 2.5 4.8e-17 61.4 1.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.4 AMD21788.1 - 0.001 19.0 2.5 0.081 12.9 0.5 2.2 2 0 0 2 2 2 2 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.12 AMD21788.1 - 0.022 14.7 1.2 0.033 14.1 0.9 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb COX17 PF05051.8 AMD21788.1 - 0.051 13.6 0.7 0.051 13.6 0.5 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Amidinotransf PF02274.12 AMD21788.1 - 0.11 11.6 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Amidinotransferase CHCH PF06747.8 AMD21788.1 - 0.46 10.4 3.1 0.8 9.6 2.2 1.4 1 0 0 1 1 1 0 CHCH domain Adaptin_N PF01602.15 AMD21789.1 - 1.7e-123 412.7 17.6 2.1e-123 412.4 12.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 AMD21789.1 - 7.1e-19 68.3 2.8 7.1e-19 68.3 2.0 3.2 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 AMD21789.1 - 1e-13 51.3 0.2 1.1e-07 32.0 0.0 4.8 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.17 AMD21789.1 - 2.9e-11 42.4 0.9 0.0073 16.3 0.0 5.9 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.1 AMD21789.1 - 0.00097 19.5 0.1 5.1 7.7 0.0 4.0 4 0 0 4 4 4 2 HEAT-like repeat Fimbrial_CS1 PF04449.7 AMD21789.1 - 0.041 13.9 2.0 0.25 11.3 0.5 2.4 2 0 0 2 2 2 0 CS1 type fimbrial major subunit Arm PF00514.18 AMD21789.1 - 0.054 13.3 0.9 3.4 7.6 0.2 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 AMD21789.1 - 0.069 12.8 1.9 1.3 8.8 0.0 3.7 4 1 1 5 5 5 0 Spinocerebellar ataxia type 10 protein domain DUF2435 PF10363.4 AMD21789.1 - 0.57 10.1 9.0 2.2 8.2 0.1 4.8 3 1 1 5 5 5 0 Protein of unknown function (DUF2435) WD40 PF00400.27 AMD21790.1 - 3.6e-55 181.9 16.6 1.2e-09 37.6 0.5 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 AMD21790.1 - 4.4e-07 28.4 10.5 0.012 13.7 0.4 4.3 1 1 4 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.6 AMD21790.1 - 0.0025 17.5 0.4 0.038 13.6 0.0 2.6 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 AMD21790.1 - 0.0057 15.4 1.4 0.25 10.0 0.3 3.1 2 2 0 3 3 3 1 Nup133 N terminal like DUF1513 PF07433.6 AMD21790.1 - 0.026 13.4 0.0 0.12 11.2 0.0 2.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1513) DUF4121 PF13497.1 AMD21790.1 - 0.12 11.3 0.0 0.22 10.4 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4121) Peptidase_M3 PF01432.15 AMD21791.1 - 9.5e-132 440.2 0.0 1.3e-131 439.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 AMD21791.1 - 0.21 10.9 0.1 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase M50B-like TPR_12 PF13424.1 AMD21792.1 - 3.4e-05 23.7 5.7 0.11 12.5 0.7 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD21792.1 - 0.081 12.7 0.7 6.9 6.7 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 AMD21792.1 - 0.79 9.7 7.0 22 5.2 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF159 PF02586.9 AMD21793.1 - 6.4e-60 202.2 0.3 8.7e-60 201.8 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, COG2135 Mur_ligase_M PF08245.7 AMD21794.1 - 1.8e-07 31.3 0.2 5.9e-07 29.7 0.0 2.0 2 1 0 2 2 2 1 Mur ligase middle domain DUF722 PF05263.6 AMD21794.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF722) DUF3894 PF13033.1 AMD21794.1 - 0.03 14.3 0.1 12 5.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3894) Mur_ligase_C PF02875.16 AMD21794.1 - 0.059 13.4 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Med11 PF10280.4 AMD21795.1 - 1.9e-21 76.3 1.1 2.1e-21 76.1 0.7 1.0 1 0 0 1 1 1 1 Mediator complex protein DASH_Dad3 PF08656.5 AMD21795.1 - 0.11 12.1 1.8 0.26 11.0 0.2 2.0 1 1 1 2 2 2 0 DASH complex subunit Dad3 GCR1_C PF12550.3 AMD21796.1 - 2.3e-27 94.6 1.4 2.7e-27 94.4 0.1 1.8 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes UBN2 PF14223.1 AMD21796.1 - 6.8 6.5 9.2 3.1 7.6 1.2 3.2 4 0 0 4 4 4 0 gag-polypeptide of LTR copia-type She2p PF11435.3 AMD21797.1 - 4.8e-67 225.3 8.8 5.8e-67 225.0 6.1 1.1 1 0 0 1 1 1 1 RNA binding protein She2p Myosin_head PF00063.16 AMD21798.1 - 2.4e-226 753.0 4.3 3.5e-226 752.4 2.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 AMD21798.1 - 1e-45 155.5 0.0 5.2e-45 153.1 0.0 2.1 2 0 0 2 2 2 1 Myosin tail SH3_1 PF00018.23 AMD21798.1 - 2.4e-11 42.8 0.0 4.4e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 AMD21798.1 - 3.6e-08 32.8 0.0 8.5e-08 31.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 AMD21798.1 - 2.1e-06 27.1 0.0 4.9e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Hpr_kinase_C PF07475.7 AMD21798.1 - 0.0071 15.6 0.1 2 7.6 0.0 2.5 2 0 0 2 2 2 1 HPr Serine kinase C-terminal domain AAA_22 PF13401.1 AMD21798.1 - 0.0096 16.0 0.0 0.029 14.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 AMD21798.1 - 0.016 14.2 0.4 0.067 12.2 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.21 AMD21798.1 - 0.031 13.7 0.0 0.069 12.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 AMD21798.1 - 0.084 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain UPF0079 PF02367.12 AMD21798.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_19 PF13245.1 AMD21798.1 - 0.13 11.9 0.0 0.4 10.4 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 AMD21798.1 - 0.18 11.4 0.0 0.37 10.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TPP_enzyme_N PF02776.13 AMD21799.1 - 1.2e-57 194.1 0.1 5e-57 192.1 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 AMD21799.1 - 6.5e-47 158.9 0.1 1e-45 155.0 0.0 2.7 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 AMD21799.1 - 6.6e-37 126.3 1.8 8.1e-37 126.0 0.3 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain His_Phos_1 PF00300.17 AMD21800.1 - 2.6e-20 73.0 0.0 3.5e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Glyco_hydro_17 PF00332.13 AMD21802.1 - 2.2e-05 23.6 0.0 2.2e-05 23.6 0.0 1.9 3 0 0 3 3 3 1 Glycosyl hydrolases family 17 Mid2 PF04478.7 AMD21803.1 - 3.7e-45 153.1 1.1 3.7e-45 153.1 0.8 2.3 2 1 0 2 2 2 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 AMD21803.1 - 0.1 11.9 3.3 0.4 10.0 2.3 2.1 1 0 0 1 1 1 0 Transmembrane alpha-helix domain E1-E2_ATPase PF00122.15 AMD21804.1 - 1.4e-75 253.3 2.3 3.4e-75 252.0 1.6 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 AMD21804.1 - 1.1e-45 155.3 1.1 1.1e-45 155.3 0.8 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 AMD21804.1 - 1.7e-30 107.0 0.1 4.3e-30 105.7 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 AMD21804.1 - 1.2e-17 63.6 0.1 2.3e-17 62.7 0.1 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 AMD21804.1 - 4.4e-17 62.8 0.0 1e-16 61.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 AMD21804.1 - 1.1e-13 50.3 0.0 2.4e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 AMD21804.1 - 7e-06 25.8 1.3 0.00026 20.6 0.7 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Sua5_yciO_yrdC PF01300.13 AMD21805.1 - 3.4e-48 163.2 0.0 1e-47 161.6 0.0 1.7 2 0 0 2 2 2 1 Telomere recombination SUA5 PF03481.8 AMD21805.1 - 2.7e-30 105.0 0.0 4.1e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding FTR1 PF03239.9 AMD21806.1 - 7.1e-88 294.4 9.2 8.3e-88 294.2 6.4 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family FAD_binding_4 PF01565.18 AMD21806.1 - 0.0028 17.1 0.1 0.022 14.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Bac_transf PF02397.11 AMD21806.1 - 0.066 12.3 0.2 0.17 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial sugar transferase DUF2456 PF10445.4 AMD21806.1 - 6.1 6.8 9.0 7.5 6.5 0.6 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2456) DUF4131 PF13567.1 AMD21806.1 - 6.8 6.0 12.3 4.6 6.6 2.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Copper-fist PF00649.13 AMD21807.1 - 9.6e-22 75.9 0.6 9.6e-22 75.9 0.4 2.8 2 1 1 3 3 3 1 Copper fist DNA binding domain Ran-binding PF05508.6 AMD21808.1 - 7.4e-102 340.3 4.7 1.1e-101 339.7 3.2 1.2 1 0 0 1 1 1 1 RanGTP-binding protein ABC_membrane_3 PF13748.1 AMD21808.1 - 0.067 12.2 0.0 0.15 11.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter transmembrane region SNF2_N PF00176.18 AMD21809.1 - 1.9e-68 230.4 0.0 3.1e-68 229.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.5 AMD21809.1 - 2.3e-52 177.6 0.4 1.6e-51 174.8 0.3 2.0 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.26 AMD21809.1 - 2e-12 46.7 0.0 4.9e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 AMD21809.1 - 5.5e-07 28.7 0.2 2.2e-06 26.7 0.2 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 AMD21809.1 - 1.8e-06 27.5 0.0 1e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Zn_clus PF00172.13 AMD21810.1 - 0.00029 20.6 0.6 0.00029 20.6 0.4 2.4 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP-synt_C PF00137.16 AMD21811.1 - 0.026 14.4 0.4 0.026 14.4 0.2 2.1 2 0 0 2 2 2 0 ATP synthase subunit C Phage_holin_5 PF06946.6 AMD21811.1 - 1.2 9.3 6.1 1 9.5 2.4 2.1 1 1 1 2 2 2 0 Phage holin Oxysterol_BP PF01237.13 AMD21812.1 - 1.6e-84 283.4 0.0 2.1e-84 283.0 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein UPF0118 PF01594.11 AMD21814.1 - 0.034 13.1 0.4 0.43 9.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF20 Ribosomal_L50 PF10501.4 AMD21815.1 - 1.2e-17 63.8 0.1 3.6e-17 62.3 0.1 1.8 1 0 0 1 1 1 1 Ribosomal subunit 39S LAMTOR PF15454.1 AMD21816.1 - 1.4e-10 41.3 8.0 2e-10 40.7 5.6 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator V_ATPase_I PF01496.14 AMD21816.1 - 0.19 9.5 2.2 0.18 9.5 1.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TBPIP PF07106.8 AMD21816.1 - 0.26 10.8 7.4 2.9 7.4 0.1 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Bromodomain PF00439.20 AMD21817.1 - 1.2e-35 121.2 6.0 9e-23 79.9 0.4 2.5 2 0 0 2 2 2 2 Bromodomain DUF1810 PF08837.6 AMD21817.1 - 0.0085 15.6 0.1 0.85 9.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1810) Sec5 PF15469.1 AMD21817.1 - 0.026 14.2 7.9 0.034 13.8 2.2 2.3 1 1 1 2 2 2 0 Exocyst complex component Sec5 LMSTEN PF07988.7 AMD21817.1 - 0.052 12.8 0.3 0.15 11.3 0.2 1.7 1 0 0 1 1 1 0 LMSTEN motif Rad21_Rec8_N PF04825.8 AMD21818.1 - 5.4e-15 55.3 0.0 1e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein DASH_Dad3 PF08656.5 AMD21819.1 - 0.22 11.2 4.6 0.33 10.6 0.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad3 NYD-SP28_assoc PF14775.1 AMD21819.1 - 0.47 10.1 3.9 0.48 10.1 0.0 2.8 3 1 0 3 3 3 0 Sperm tail C-terminal domain Cep57_MT_bd PF06657.8 AMD21819.1 - 4.2 7.3 7.2 0.7 9.8 0.1 2.5 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 GldM_N PF12081.3 AMD21819.1 - 5.4 6.4 8.2 12 5.3 1.0 2.3 2 1 0 2 2 2 0 GldM N-terminal domain GLTP PF08718.6 AMD21819.1 - 6.2 6.8 6.6 7.9 6.5 4.2 1.5 1 1 0 1 1 1 0 Glycolipid transfer protein (GLTP) eIF2A PF08662.6 AMD21820.1 - 5.9e-76 254.5 0.0 9.1e-75 250.6 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 AMD21820.1 - 0.0074 16.1 0.2 25 4.9 0.0 4.5 3 1 0 3 3 3 1 WD domain, G-beta repeat Fascin PF06268.8 AMD21820.1 - 0.032 14.3 0.0 3.3 7.8 0.0 2.6 2 0 0 2 2 2 0 Fascin domain ETRAMP PF09716.5 AMD21822.1 - 0.17 11.8 1.3 1.1 9.2 0.0 2.3 2 2 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) IlvC PF01450.14 AMD21823.1 - 1.8e-46 157.6 0.0 2.7e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvN PF07991.7 AMD21823.1 - 3.2e-46 156.7 0.0 4.6e-46 156.1 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.10 AMD21823.1 - 0.044 13.6 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 AMD21823.1 - 0.096 13.1 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Transaldolase PF00923.14 AMD21824.1 - 1.2e-98 329.7 0.8 1.4e-98 329.5 0.5 1.0 1 0 0 1 1 1 1 Transaldolase Zn_clus PF00172.13 AMD21825.1 - 2.9e-08 33.4 10.0 4.8e-08 32.7 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2248 PF10005.4 AMD21825.1 - 0.085 11.7 3.1 0.09 11.6 2.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2248) DUF2797 PF10977.3 AMD21825.1 - 0.24 10.9 2.4 0.32 10.5 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) DUF2439 PF10382.4 AMD21826.1 - 2.9e-24 85.0 3.9 3e-24 85.0 1.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) LRR_4 PF12799.2 AMD21828.1 - 2.2e-05 23.9 6.2 0.00029 20.3 0.6 4.0 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 AMD21828.1 - 0.034 14.2 6.7 49 4.7 0.0 5.9 6 0 0 6 6 6 0 Leucine rich repeat LRR_8 PF13855.1 AMD21828.1 - 0.56 9.9 5.0 0.54 10.0 0.8 3.0 4 0 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.28 AMD21828.1 - 0.81 9.9 10.6 19 5.7 0.1 5.6 5 2 1 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.1 AMD21828.1 - 3.6 7.9 10.1 28 5.1 0.0 5.0 6 0 0 6 6 6 0 Leucine Rich repeat Pkinase PF00069.20 AMD21829.1 - 2.7e-74 249.6 0.0 3.5e-74 249.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21829.1 - 5.8e-32 110.7 0.0 9.2e-32 110.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21829.1 - 6.2e-06 25.3 0.0 1.2e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 AMD21829.1 - 0.00015 20.9 0.0 0.00025 20.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD21829.1 - 0.0079 15.9 0.1 0.018 14.7 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family CN_hydrolase PF00795.17 AMD21830.1 - 1.1e-30 106.3 0.0 1.5e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ORMDL PF04061.9 AMD21831.1 - 1.7e-57 192.7 5.8 2e-57 192.5 4.0 1.1 1 0 0 1 1 1 1 ORMDL family ACBP PF00887.14 AMD21832.1 - 6.6e-29 99.4 1.2 7.2e-29 99.2 0.8 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.13 AMD21832.1 - 0.015 15.5 0.2 0.059 13.5 0.0 1.8 1 1 1 2 2 2 0 FERM central domain HEAT PF02985.17 AMD21833.1 - 5.1e-22 75.9 16.0 9.7e-05 22.1 0.0 11.3 12 0 0 12 12 12 6 HEAT repeat IBN_N PF03810.14 AMD21833.1 - 7.3e-12 45.0 1.1 8.5e-11 41.6 0.3 3.3 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_EZ PF13513.1 AMD21833.1 - 1.6e-11 44.3 10.8 1.2e-05 25.6 0.0 8.3 7 2 3 10 10 10 2 HEAT-like repeat HEAT_2 PF13646.1 AMD21833.1 - 2.8e-10 40.3 14.5 0.00018 21.7 0.0 7.6 1 1 4 6 6 6 3 HEAT repeats CLASP_N PF12348.3 AMD21833.1 - 1.3e-05 24.6 0.5 0.31 10.3 0.0 4.5 4 1 1 5 5 5 2 CLASP N terminal Arm PF00514.18 AMD21833.1 - 0.0013 18.4 11.7 0.011 15.5 0.1 6.2 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat PAP2 PF01569.16 AMD21834.1 - 1.7e-18 66.5 1.0 1.7e-18 66.5 0.7 1.5 2 0 0 2 2 2 1 PAP2 superfamily 6PF2K PF01591.13 AMD21835.1 - 5.6e-59 198.9 0.1 7.9e-59 198.4 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 AMD21835.1 - 1.9e-18 67.0 0.1 1.2e-17 64.3 0.0 2.2 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.5 AMD21835.1 - 0.018 14.2 0.0 0.039 13.1 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.1 AMD21835.1 - 0.036 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain KOW PF00467.24 AMD21836.1 - 0.0011 18.6 1.6 0.002 17.7 0.0 2.2 3 0 0 3 3 3 1 KOW motif TIM21 PF08294.6 AMD21837.1 - 2.8e-52 176.2 0.0 3.6e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 TIM21 60KD_IMP PF02096.15 AMD21837.1 - 0.054 13.1 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein DUF4064 PF13273.1 AMD21837.1 - 0.059 13.4 0.2 0.098 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Glyco_hydro_72 PF03198.9 AMD21838.1 - 3.5e-138 459.8 0.3 4.6e-138 459.4 0.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 AMD21838.1 - 2.3e-13 50.4 0.5 7e-13 48.8 0.3 1.8 1 0 0 1 1 1 1 X8 domain Glucan_synthase PF02364.10 AMD21839.1 - 0 1429.7 0.0 0 1429.7 0.0 1.6 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 AMD21839.1 - 1e-37 128.6 0.1 2.5e-37 127.3 0.0 1.7 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 HTH_19 PF12844.2 AMD21839.1 - 0.12 12.4 0.3 0.29 11.2 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Abhydrolase_6 PF12697.2 AMD21840.1 - 9e-27 94.4 0.0 1.1e-26 94.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD21840.1 - 9.1e-15 54.8 0.0 2.3e-13 50.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AMD21840.1 - 9.3e-12 44.9 0.0 1.3e-11 44.4 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 AMD21840.1 - 2.6e-07 31.0 0.0 3.9e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 AMD21840.1 - 9.3e-05 22.1 0.0 0.00031 20.3 0.0 1.8 1 1 0 1 1 1 1 PGAP1-like protein Esterase PF00756.15 AMD21840.1 - 0.0041 16.5 0.0 0.0057 16.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.8 AMD21840.1 - 0.0045 16.5 0.0 0.0056 16.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.6 AMD21840.1 - 0.022 13.8 0.1 0.078 12.0 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydro_lipase PF04083.11 AMD21840.1 - 0.064 12.6 0.1 2.1 7.7 0.0 2.9 3 0 0 3 3 3 0 Partial alpha/beta-hydrolase lipase region Lipase_3 PF01764.20 AMD21840.1 - 0.069 12.7 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.3 AMD21840.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase Ribosomal_L10 PF00466.15 AMD21842.1 - 1.9e-27 95.1 0.2 3.8e-27 94.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 AMD21842.1 - 4.3e-19 68.6 3.8 4.3e-19 68.6 2.6 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein Alba PF01918.16 AMD21843.1 - 1.9e-06 27.3 0.1 3.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Alba Arv1 PF04161.8 AMD21843.1 - 0.2 11.5 3.3 0.24 11.2 2.3 1.1 1 0 0 1 1 1 0 Arv1-like family EMP24_GP25L PF01105.19 AMD21845.1 - 7.8e-45 152.8 0.7 8.9e-45 152.6 0.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Phage_Coat_Gp8 PF05371.7 AMD21845.1 - 0.043 13.3 3.2 10 5.7 0.0 3.1 3 0 0 3 3 3 0 Phage major coat protein, Gp8 WD40 PF00400.27 AMD21846.1 - 6.4e-15 54.3 11.7 6.1e-05 22.7 3.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat Lgl_C PF08596.5 AMD21846.1 - 0.0094 14.4 0.1 0.1 11.0 0.0 2.1 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal eIF2A PF08662.6 AMD21846.1 - 0.012 15.3 0.0 0.094 12.4 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 AMD21847.1 - 2.3e-32 109.6 0.2 5.7e-06 25.9 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 AMD21847.1 - 0.00012 21.8 0.3 0.015 14.9 0.2 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Rep_fac-A_C PF08646.5 AMD21848.1 - 6.9e-57 191.2 1.9 3.3e-54 182.5 0.4 2.7 2 1 0 2 2 2 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 AMD21848.1 - 1.5e-17 63.2 0.5 5.1e-10 39.0 0.0 4.7 4 1 0 4 4 4 4 OB-fold nucleic acid binding domain Rep-A_N PF04057.7 AMD21848.1 - 0.0054 16.4 0.5 0.022 14.5 0.1 2.1 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain DUF421 PF04239.7 AMD21848.1 - 0.088 12.3 0.0 0.25 10.8 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF421) WD40 PF00400.27 AMD21849.1 - 1.7e-17 62.5 7.6 7.4e-08 31.9 0.0 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat Vps53_N PF04100.7 AMD21850.1 - 0.00084 18.2 3.8 0.00096 18.0 2.6 1.1 1 0 0 1 1 1 1 Vps53-like, N-terminal COG5 PF10392.4 AMD21850.1 - 0.0031 17.4 4.3 0.012 15.5 3.0 2.0 1 1 0 1 1 1 1 Golgi transport complex subunit 5 Tropomyosin_1 PF12718.2 AMD21850.1 - 0.0044 16.8 1.1 0.0044 16.8 0.8 2.0 2 0 0 2 2 2 1 Tropomyosin like MutS_III PF05192.13 AMD21850.1 - 0.0054 16.5 0.4 0.01 15.6 0.3 1.5 1 0 0 1 1 1 1 MutS domain III Snapin_Pallidin PF14712.1 AMD21850.1 - 0.02 15.1 0.6 0.02 15.1 0.4 2.5 3 0 0 3 3 3 0 Snapin/Pallidin LOH1CR12 PF10158.4 AMD21850.1 - 0.029 14.1 0.4 0.15 11.8 0.2 1.9 1 1 1 2 2 2 0 Tumour suppressor protein ORF6C PF10552.4 AMD21850.1 - 0.029 14.0 1.6 0.26 11.0 0.1 2.4 1 1 1 2 2 2 0 ORF6C domain Streptin-Immun PF11083.3 AMD21850.1 - 0.32 10.9 7.3 0.15 12.0 2.3 2.3 1 1 0 2 2 2 0 Lantibiotic streptin immunity protein Phage_GP20 PF06810.6 AMD21850.1 - 0.49 9.8 11.1 1.4 8.3 6.2 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 E1-E2_ATPase PF00122.15 AMD21851.1 - 4e-62 209.2 0.5 4e-62 209.2 0.3 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 AMD21851.1 - 3.4e-43 147.2 6.8 3.4e-43 147.2 4.7 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 AMD21851.1 - 1.8e-22 80.7 0.0 1.3e-21 77.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 AMD21851.1 - 6.2e-15 54.9 0.0 1.6e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 AMD21851.1 - 2e-11 44.4 0.0 6e-11 42.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 AMD21851.1 - 8.3e-09 34.7 0.0 2.3e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 AMD21851.1 - 0.00019 21.0 0.8 0.00049 19.7 0.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase tRNA_int_endo PF01974.12 AMD21852.1 - 2.1e-13 49.8 0.0 4.4e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain FOP_dimer PF09398.5 AMD21853.1 - 0.11 12.4 0.1 0.37 10.8 0.0 1.8 1 0 0 1 1 1 0 FOP N terminal dimerisation domain B-block_TFIIIC PF04182.7 AMD21854.1 - 5e-16 58.3 0.0 1.7e-15 56.6 0.0 2.0 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC N6-adenineMlase PF10237.4 AMD21855.1 - 1.7e-60 203.3 0.4 2.4e-60 202.8 0.2 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase 3Beta_HSD PF01073.14 AMD21856.1 - 4.6e-83 278.1 0.0 5.6e-83 277.8 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 AMD21856.1 - 7.4e-29 100.8 0.0 9.6e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 AMD21856.1 - 1.6e-15 56.7 0.0 9e-15 54.2 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 AMD21856.1 - 2.6e-13 49.5 0.0 4.1e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 AMD21856.1 - 9.6e-08 31.2 0.0 4.6e-07 29.0 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 AMD21856.1 - 5.3e-07 29.8 0.0 7.8e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 AMD21856.1 - 8e-05 22.6 0.0 0.00045 20.1 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AMD21856.1 - 0.0014 18.3 0.0 0.0065 16.1 0.0 1.9 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 AMD21856.1 - 0.0017 17.6 0.0 0.0023 17.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Vps8 PF12816.2 AMD21857.1 - 4.7e-56 189.1 8.9 5.2e-55 185.7 3.6 2.6 2 0 0 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.15 AMD21857.1 - 2.1e-08 33.8 2.1 1e-05 25.1 0.1 3.4 2 1 1 3 3 3 2 Region in Clathrin and VPS zf-C3HC4 PF00097.20 AMD21857.1 - 0.0046 16.5 1.3 0.0046 16.5 0.9 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD21857.1 - 0.013 15.3 1.2 0.013 15.3 0.8 2.2 2 0 0 2 2 2 0 Ring finger domain EF1_GNE PF00736.14 AMD21858.1 - 4.6e-32 109.5 2.6 8.8e-32 108.6 1.8 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 AMD21858.1 - 4.3e-13 49.1 6.1 4.3e-13 49.1 4.2 2.8 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region GST_C PF00043.20 AMD21858.1 - 0.05 13.6 2.1 0.28 11.1 0.1 2.6 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 AMD21858.1 - 0.066 13.7 0.0 0.18 12.3 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF4291 PF14124.1 AMD21858.1 - 0.32 10.5 4.1 8.8 5.9 2.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4291) MRC1 PF09444.5 AMD21858.1 - 9.5 6.5 12.8 0.39 11.0 4.8 1.6 2 0 0 2 2 2 0 MRC1-like domain SNF5 PF04855.7 AMD21859.1 - 1.8e-66 224.1 2.1 1.1e-40 139.6 0.0 2.3 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 CHD5 PF04420.9 AMD21861.1 - 3e-38 131.0 2.6 3.4e-38 130.8 1.8 1.1 1 0 0 1 1 1 1 CHD5-like protein GED PF02212.13 AMD21861.1 - 0.0016 18.2 0.2 0.0027 17.5 0.1 1.4 1 0 0 1 1 1 1 Dynamin GTPase effector domain ExbD PF02472.11 AMD21861.1 - 0.0042 17.0 0.5 0.0061 16.5 0.3 1.3 1 0 0 1 1 1 1 Biopolymer transport protein ExbD/TolR RE_TaqI PF09573.5 AMD21861.1 - 0.0062 15.7 0.6 0.0083 15.2 0.4 1.1 1 0 0 1 1 1 1 TaqI restriction endonuclease LRS4 PF10422.4 AMD21861.1 - 0.17 11.2 6.4 0.22 10.8 4.4 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 UCH PF00443.24 AMD21862.1 - 1.2e-67 227.8 0.7 1.2e-67 227.8 0.5 2.1 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD21862.1 - 1.7e-24 86.8 0.3 1.7e-24 86.8 0.2 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 AMD21862.1 - 0.0016 18.7 0.0 0.0044 17.3 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.15 AMD21862.1 - 0.012 15.1 3.2 0.012 15.1 2.2 2.4 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Zn-ribbon_8 PF09723.5 AMD21862.1 - 0.053 13.4 3.7 0.37 10.7 1.3 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Y_phosphatase2 PF03162.8 AMD21863.1 - 2.6e-52 176.5 0.3 3e-52 176.2 0.2 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 AMD21863.1 - 0.051 13.8 0.0 0.092 12.9 0.0 1.4 1 1 0 1 1 1 0 Tyrosine phosphatase family Phage_glycop_gL PF11108.3 AMD21863.1 - 0.055 13.4 1.1 0.088 12.7 0.3 1.6 2 0 0 2 2 2 0 Viral glycoprotein L Vezatin PF12632.2 AMD21863.1 - 0.061 12.3 0.8 0.1 11.6 0.5 1.4 1 1 0 1 1 1 0 Mysoin-binding motif of peroxisomes Asp_protease PF09668.5 AMD21864.1 - 2.3e-50 169.3 0.1 4.1e-50 168.4 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 AMD21864.1 - 1.5e-09 38.1 0.1 3.2e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 AMD21864.1 - 2.8e-08 33.5 0.1 6.6e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA PF00627.26 AMD21864.1 - 7.8e-08 31.9 0.0 2.7e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 UBA/TS-N domain RVP_2 PF08284.6 AMD21864.1 - 4e-06 26.8 0.0 7.2e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 AMD21864.1 - 4.6e-05 23.1 0.0 0.0001 22.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Peptidase_A2B PF12384.3 AMD21864.1 - 0.019 14.2 0.1 0.073 12.3 0.0 2.0 1 1 1 2 2 2 0 Ty3 transposon peptidase RuvA_C PF07499.8 AMD21864.1 - 0.15 12.2 0.0 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 RuvA, C-terminal domain COX15-CtaA PF02628.10 AMD21865.1 - 3.8e-101 337.9 3.8 4.6e-101 337.6 2.6 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein CD20 PF04103.10 AMD21865.1 - 0.14 12.1 2.2 1.5 8.7 0.5 2.6 3 0 0 3 3 3 0 CD20-like family Claudin_2 PF13903.1 AMD21865.1 - 0.21 11.2 3.6 2.4 7.8 0.2 3.0 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction DUF4131 PF13567.1 AMD21865.1 - 0.97 8.8 10.1 0.14 11.5 0.5 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4131) Lon_C PF05362.8 AMD21866.1 - 1.7e-65 220.1 0.0 3.6e-65 219.1 0.0 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 AMD21866.1 - 1.4e-27 96.7 1.2 3.6e-27 95.3 0.1 2.2 2 0 0 2 2 2 1 ATP-dependent protease La (LON) domain AAA PF00004.24 AMD21866.1 - 2.5e-23 82.7 0.0 8.7e-23 80.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 AMD21866.1 - 1.5e-06 28.2 0.0 4.3e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 AMD21866.1 - 3.6e-06 26.7 0.0 1.4e-05 24.8 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.1 AMD21866.1 - 2.7e-05 23.6 0.0 5.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_22 PF13401.1 AMD21866.1 - 4.8e-05 23.5 0.1 0.0023 18.0 0.1 3.2 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 AMD21866.1 - 0.00025 20.1 0.0 0.0027 16.8 0.0 2.5 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 AMD21866.1 - 0.0006 19.8 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_PrkA PF08298.6 AMD21866.1 - 0.00061 18.5 0.0 0.0013 17.5 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_17 PF13207.1 AMD21866.1 - 0.0013 19.5 0.0 0.0076 17.0 0.0 2.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AMD21866.1 - 0.0016 18.3 0.0 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 AMD21866.1 - 0.0025 17.2 0.0 0.0053 16.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.6 AMD21866.1 - 0.0049 16.4 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 AMD21866.1 - 0.0072 16.6 0.4 0.042 14.1 0.0 2.7 3 0 0 3 3 1 1 AAA domain DUF258 PF03193.11 AMD21866.1 - 0.021 14.0 0.0 0.044 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SKI PF01202.17 AMD21866.1 - 0.031 14.1 0.4 0.11 12.3 0.0 2.3 2 0 0 2 2 1 0 Shikimate kinase NTPase_1 PF03266.10 AMD21866.1 - 0.032 13.9 2.2 0.76 9.4 0.1 3.0 2 1 1 3 3 3 0 NTPase NACHT PF05729.7 AMD21866.1 - 0.045 13.4 0.0 0.55 9.8 0.0 2.3 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 AMD21866.1 - 0.062 13.4 0.0 0.2 11.8 0.0 2.0 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 AMD21866.1 - 0.081 13.2 0.5 0.38 11.0 0.0 2.4 2 0 0 2 2 2 0 ABC transporter CBFD_NFYB_HMF PF00808.18 AMD21867.1 - 7.6e-26 89.9 0.1 1.2e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 AMD21867.1 - 4.2e-06 26.7 0.0 6.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 AMD21867.1 - 0.0047 16.6 0.1 0.048 13.3 0.0 2.2 2 0 0 2 2 2 1 Bromodomain associated TFIID_20kDa PF03847.8 AMD21867.1 - 0.013 15.7 0.3 0.075 13.3 0.1 2.2 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Rft-1 PF04506.8 AMD21868.1 - 2.6e-160 534.4 39.5 3.2e-160 534.1 27.4 1.0 1 0 0 1 1 1 1 Rft protein DUF3800 PF12686.2 AMD21868.1 - 0.05 13.2 0.2 0.05 13.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3800) Exo_endo_phos PF03372.18 AMD21869.1 - 1.8e-19 70.6 0.0 2.5e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 AMD21869.1 - 5.3e-13 48.6 0.1 6.9e-12 45.0 0.1 2.3 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase zf-GRF PF06839.7 AMD21869.1 - 2.3e-07 30.6 1.8 4.9e-07 29.5 1.2 1.6 1 0 0 1 1 1 1 GRF zinc finger BNR PF02012.15 AMD21871.1 - 2.9e-11 41.4 31.4 0.091 12.6 0.1 10.8 11 0 0 11 11 11 8 BNR/Asp-box repeat Mo-co_dimer PF03404.11 AMD21871.1 - 0.039 13.5 0.2 40 3.8 0.0 4.2 5 0 0 5 5 5 0 Mo-co oxidoreductase dimerisation domain Pkinase PF00069.20 AMD21872.1 - 2.4e-72 243.2 0.0 2.9e-72 242.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21872.1 - 5e-32 110.9 0.0 6.7e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21872.1 - 0.022 13.7 0.0 0.072 12.0 0.0 1.7 1 1 0 1 1 1 0 Kinase-like APH PF01636.18 AMD21872.1 - 0.047 13.4 0.2 0.16 11.6 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 AMD21872.1 - 0.1 11.6 0.2 0.22 10.5 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family AcetylCoA_hydro PF02550.10 AMD21873.1 - 1.8e-59 200.8 0.0 2.8e-59 200.2 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.1 AMD21873.1 - 1.2e-39 135.5 0.0 2.6e-39 134.3 0.0 1.6 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.7 AMD21873.1 - 0.003 16.2 0.1 0.013 14.2 0.0 1.8 2 0 0 2 2 2 1 Citrate lyase, alpha subunit (CitF) Acid_PPase PF12689.2 AMD21874.1 - 3.9e-38 130.7 0.0 4.3e-38 130.5 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase DUF2046 PF09755.4 AMD21875.1 - 0.014 14.2 0.1 0.019 13.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) MerR_2 PF13591.1 AMD21875.1 - 0.025 14.1 1.0 0.046 13.3 0.7 1.5 1 0 0 1 1 1 0 MerR HTH family regulatory protein NYD-SP28_assoc PF14775.1 AMD21875.1 - 1.6 8.4 4.1 1.3 8.8 0.4 2.2 2 0 0 2 2 2 0 Sperm tail C-terminal domain Collagen PF01391.13 AMD21876.1 - 4.6e-40 134.9 483.3 0.00085 18.8 20.9 23.5 7 5 8 15 15 15 7 Collagen triple helix repeat (20 copies) MIP-T3 PF10243.4 AMD21876.1 - 0.15 10.4 17.2 0.3 9.5 11.9 1.4 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RRM_1 PF00076.17 AMD21877.1 - 1.1e-40 137.1 0.0 1.6e-19 69.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21877.1 - 4.9e-28 96.9 0.0 7e-15 54.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD21877.1 - 3.7e-20 71.5 0.0 5.1e-10 39.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prothymosin PF03247.9 AMD21877.1 - 9.3 6.4 46.7 24 5.1 11.0 2.4 1 1 1 2 2 2 0 Prothymosin/parathymosin family Arrestin_N PF00339.24 AMD21878.1 - 1.4e-16 60.6 0.0 4.3e-16 59.0 0.0 1.9 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 AMD21878.1 - 1.3e-05 25.3 4.2 3.9e-05 23.7 0.1 3.0 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.10 AMD21878.1 - 0.046 12.5 0.0 0.17 10.6 0.0 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 26 RNase_PH PF01138.16 AMD21879.1 - 6.8e-19 68.4 0.0 9.1e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PEMT PF04191.8 AMD21880.1 - 1.9e-50 169.3 19.3 9.3e-28 96.4 1.4 3.5 3 1 0 3 3 3 2 Phospholipid methyltransferase Septin PF00735.13 AMD21881.1 - 1.4e-113 378.5 0.8 1.4e-113 378.5 0.6 1.9 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 AMD21881.1 - 1e-06 28.6 0.8 3e-06 27.1 0.1 2.4 2 2 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 AMD21881.1 - 0.00047 19.3 0.2 0.0027 16.9 0.2 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 AMD21881.1 - 0.00097 19.1 0.9 0.01 15.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 AMD21881.1 - 0.0031 17.7 2.7 0.072 13.3 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.1 AMD21881.1 - 0.012 15.7 0.4 0.12 12.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_10 PF12846.2 AMD21881.1 - 0.013 14.9 1.3 0.22 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain GTP_EFTU PF00009.22 AMD21881.1 - 0.013 14.9 4.2 0.046 13.1 0.0 3.1 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Lipocalin PF00061.18 AMD21881.1 - 0.013 15.4 1.5 0.036 14.0 1.1 1.7 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family AAA_33 PF13671.1 AMD21881.1 - 0.014 15.2 0.0 0.042 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 AMD21881.1 - 0.043 13.7 2.6 0.045 13.6 0.0 2.4 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.18 AMD21881.1 - 0.084 12.6 12.4 0.14 11.9 0.4 3.6 2 2 0 2 2 2 0 Dynamin family AIG1 PF04548.11 AMD21881.1 - 0.092 11.8 7.2 0.59 9.2 0.0 3.0 3 0 0 3 3 3 0 AIG1 family Miro PF08477.8 AMD21881.1 - 0.14 12.6 1.8 0.44 11.0 0.0 2.7 2 2 0 2 2 2 0 Miro-like protein DUF2937 PF11157.3 AMD21881.1 - 0.41 9.9 4.9 0.79 9.0 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) DUF342 PF03961.8 AMD21881.1 - 1.1 7.6 14.2 1.9 6.8 9.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.9 AMD21881.1 - 3.1 7.3 15.6 7.7 6.0 10.8 1.7 1 0 0 1 1 1 0 IncA protein SHNi-TPR PF10516.4 AMD21882.1 - 1e-16 59.8 3.0 8.2e-16 56.9 1.0 3.1 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.1 AMD21882.1 - 0.0014 18.5 10.4 0.031 14.2 0.5 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 AMD21882.1 - 0.002 17.9 0.2 1.5 8.8 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 AMD21882.1 - 0.0091 15.6 7.9 0.22 11.2 0.1 2.9 2 1 1 3 3 3 3 TPR repeat TPR_16 PF13432.1 AMD21882.1 - 0.11 13.2 4.2 10 6.9 0.1 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat Daxx PF03344.10 AMD21882.1 - 0.11 10.9 34.8 0.14 10.6 24.1 1.4 1 0 0 1 1 1 0 Daxx Family TPR_2 PF07719.12 AMD21882.1 - 0.21 11.5 14.1 0.29 11.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 AMD21882.1 - 1.1 9.1 4.8 4 7.3 0.9 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat UPF0121 PF03661.8 AMD21883.1 - 3.2e-11 42.9 1.9 4.4e-11 42.4 1.3 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) HSP70 PF00012.15 AMD21884.1 - 1.9e-273 907.9 7.6 2.2e-273 907.7 5.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 AMD21884.1 - 4.5e-18 64.9 0.0 6.8e-17 61.0 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 AMD21884.1 - 0.00085 18.9 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 AMD21884.1 - 0.0027 16.8 1.9 0.0064 15.6 0.0 2.4 2 1 1 3 3 3 1 Hydantoinase/oxoprolinase DUF1484 PF07363.6 AMD21884.1 - 0.055 13.8 0.4 10 6.5 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1484) DUF3599 PF12206.3 AMD21885.1 - 0.0064 16.7 0.0 0.0071 16.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3599) SAICAR_synt PF01259.13 AMD21885.1 - 0.033 13.2 0.0 0.036 13.1 0.0 1.0 1 0 0 1 1 1 0 SAICAR synthetase DUF2586 PF10758.4 AMD21885.1 - 0.092 11.7 0.0 0.1 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2586) COX6A PF02046.10 AMD21886.1 - 4.7e-40 136.1 0.7 5e-40 136.0 0.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa WD40 PF00400.27 AMD21887.1 - 2e-18 65.4 2.4 0.0056 16.5 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Flo11 PF10182.4 AMD21887.1 - 0.025 14.1 0.1 0.053 13.0 0.1 1.6 1 0 0 1 1 1 0 Flo11 domain Ribosomal_S26e PF01283.14 AMD21888.1 - 2.4e-50 169.5 9.1 2.9e-50 169.2 6.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e DUF1101 PF06503.6 AMD21888.1 - 0.043 12.6 0.1 0.047 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1101) COX5B PF01215.14 AMD21889.1 - 1.1e-54 183.7 0.0 1.4e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb RabGAP-TBC PF00566.13 AMD21890.1 - 0.00014 21.3 5.1 0.022 14.2 0.3 3.0 3 0 0 3 3 3 2 Rab-GTPase-TBC domain WSC PF01822.14 AMD21891.1 - 2.2e-09 37.1 9.8 6.8e-09 35.5 6.8 1.9 1 0 0 1 1 1 1 WSC domain SIT PF15330.1 AMD21891.1 - 0.069 13.2 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT zf-C2H2 PF00096.21 AMD21892.1 - 6.5e-06 26.1 24.7 0.00016 21.7 2.3 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-met PF12874.2 AMD21892.1 - 0.0044 17.1 0.5 0.0044 17.1 0.4 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 AMD21892.1 - 0.0059 16.8 3.6 0.0059 16.8 2.5 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.3 AMD21892.1 - 0.0095 16.0 1.5 0.018 15.1 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 AMD21892.1 - 0.068 13.5 1.0 0.068 13.5 0.7 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2HC_2 PF13913.1 AMD21892.1 - 0.087 12.5 1.2 0.19 11.4 0.8 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Clp1 PF06807.9 AMD21893.1 - 2.4e-05 24.2 0.0 0.00043 20.1 0.0 2.4 2 1 0 2 2 2 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 AMD21893.1 - 0.00047 19.8 0.1 0.00098 18.8 0.1 1.6 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 AMD21893.1 - 0.014 15.3 1.2 0.053 13.4 0.2 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase G-alpha PF00503.15 AMD21893.1 - 0.014 14.0 0.1 0.021 13.5 0.1 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Arf PF00025.16 AMD21893.1 - 0.09 12.0 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_14 PF13173.1 AMD21893.1 - 0.11 12.3 0.0 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.5 AMD21893.1 - 0.11 11.6 0.0 0.94 8.6 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit FtsK_SpoIIIE PF01580.13 AMD21893.1 - 0.19 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA PF00004.24 AMD21894.1 - 4.7e-93 308.3 0.0 4e-47 159.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD21894.1 - 2.6e-14 52.8 0.0 2.7e-07 29.8 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 AMD21894.1 - 5.4e-12 46.0 1.0 0.00021 21.3 0.0 3.7 3 2 0 3 3 2 2 AAA ATPase domain AAA_17 PF13207.1 AMD21894.1 - 6e-12 46.4 0.0 8.2e-07 29.8 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.1 AMD21894.1 - 1.1e-11 44.9 0.3 0.0062 16.6 0.0 5.6 3 2 1 4 4 4 2 AAA domain AAA_14 PF13173.1 AMD21894.1 - 4.3e-11 42.7 0.0 0.0015 18.3 0.0 3.8 4 0 0 4 4 4 2 AAA domain AAA_2 PF07724.9 AMD21894.1 - 6.2e-11 42.5 0.0 0.00052 19.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.7 AMD21894.1 - 1.5e-10 40.5 0.0 0.00058 19.0 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_33 PF13671.1 AMD21894.1 - 6.8e-10 38.9 0.0 0.00043 20.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 AMD21894.1 - 2.7e-09 36.8 0.1 0.0047 16.6 0.0 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 AMD21894.1 - 7.1e-09 36.0 0.0 8.6e-05 22.8 0.0 2.9 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 AMD21894.1 - 7.5e-09 34.7 0.0 0.00022 20.0 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus RNA_helicase PF00910.17 AMD21894.1 - 2.3e-07 30.9 0.0 0.014 15.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.22 AMD21894.1 - 4.6e-07 30.2 0.0 0.019 15.2 0.0 2.8 2 0 0 2 2 2 2 ABC transporter Vps4_C PF09336.5 AMD21894.1 - 5.8e-07 29.2 0.1 0.00024 20.9 0.0 3.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.12 AMD21894.1 - 5.9e-07 29.0 0.2 0.022 14.1 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_19 PF13245.1 AMD21894.1 - 1e-06 28.3 0.2 0.076 12.7 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain AAA_28 PF13521.1 AMD21894.1 - 1.1e-06 28.7 0.0 0.024 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 AMD21894.1 - 3.1e-06 26.5 0.3 0.043 12.9 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 AMD21894.1 - 3.9e-06 26.3 2.3 2.5 7.4 0.0 4.3 2 2 1 4 4 4 1 AAA domain AAA_3 PF07726.6 AMD21894.1 - 6.8e-06 25.7 0.0 0.035 13.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 AMD21894.1 - 8.7e-06 25.6 0.0 0.064 13.1 0.0 3.2 3 0 0 3 3 2 2 Shikimate kinase Cytidylate_kin2 PF13189.1 AMD21894.1 - 1.8e-05 24.7 0.0 0.0015 18.4 0.0 2.6 2 0 0 2 2 2 1 Cytidylate kinase-like family NACHT PF05729.7 AMD21894.1 - 2.9e-05 23.8 0.1 0.66 9.6 0.0 3.5 4 0 0 4 4 3 2 NACHT domain Rad17 PF03215.10 AMD21894.1 - 7.5e-05 21.6 0.0 0.03 13.0 0.0 2.4 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 AMD21894.1 - 0.00023 20.9 0.0 2.5 7.7 0.0 3.5 2 2 1 3 3 3 2 Archaeal ATPase Viral_helicase1 PF01443.13 AMD21894.1 - 0.00025 20.6 0.0 0.79 9.1 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF815 PF05673.8 AMD21894.1 - 0.0003 19.7 0.0 0.095 11.6 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 AMD21894.1 - 0.00031 20.2 0.0 0.24 10.8 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 AMD21894.1 - 0.00034 20.6 0.0 0.67 10.0 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.17 AMD21894.1 - 0.00055 18.8 0.0 0.32 9.7 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain CPT PF07931.7 AMD21894.1 - 0.00089 18.9 0.0 0.021 14.4 0.0 2.4 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_11 PF13086.1 AMD21894.1 - 0.001 18.7 0.4 0.96 8.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain KaiC PF06745.8 AMD21894.1 - 0.002 17.3 0.1 1.4 7.9 0.0 3.1 2 1 0 3 3 3 1 KaiC Parvo_NS1 PF01057.12 AMD21894.1 - 0.0023 16.8 0.1 1.6 7.5 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ATP-synt_ab PF00006.20 AMD21894.1 - 0.0026 17.2 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.1 AMD21894.1 - 0.003 17.1 0.0 2.3 7.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.5 AMD21894.1 - 0.0065 15.7 0.0 1.9 7.6 0.0 2.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PhoH PF02562.11 AMD21894.1 - 0.0071 15.6 0.0 1.6 7.9 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein PduV-EutP PF10662.4 AMD21894.1 - 0.013 14.9 0.0 5.6 6.4 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 AMD21894.1 - 0.018 14.7 0.0 4.1 7.0 0.0 2.6 2 0 0 2 2 2 0 NTPase UPF0079 PF02367.12 AMD21894.1 - 0.018 14.6 0.0 7.2 6.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 MMR_HSR1 PF01926.18 AMD21894.1 - 0.018 14.9 0.1 3.2 7.7 0.0 3.6 3 1 0 3 3 3 0 50S ribosome-binding GTPase ResIII PF04851.10 AMD21894.1 - 0.047 13.5 0.0 5.3 6.8 0.0 2.8 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit AFG1_ATPase PF03969.11 AMD21894.1 - 0.061 12.1 0.0 10 4.7 0.0 2.6 3 0 0 3 3 2 0 AFG1-like ATPase KTI12 PF08433.5 AMD21894.1 - 0.062 12.4 1.0 4 6.5 0.0 3.2 3 0 0 3 3 3 0 Chromatin associated protein KTI12 DUF258 PF03193.11 AMD21894.1 - 0.066 12.4 0.0 1 8.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 FeoB_N PF02421.13 AMD21894.1 - 0.075 12.3 0.1 2.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.1 AMD21894.1 - 0.15 11.5 0.0 8.8 5.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.1 AMD21894.1 - 2.5 8.3 6.5 2.1 8.6 0.0 3.3 3 1 0 3 3 2 0 AAA domain KH_dom-like PF14714.1 AMD21895.1 - 0.0025 17.7 0.5 0.0061 16.4 0.4 1.7 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal Complex1_LYR PF05347.10 AMD21895.1 - 0.14 12.0 2.1 0.38 10.5 1.5 1.8 1 0 0 1 1 1 0 Complex 1 protein (LYR family) KH_1 PF00013.24 AMD21896.1 - 7.8e-15 54.2 0.1 2.2e-07 30.4 0.0 4.2 4 0 0 4 4 4 2 KH domain KH_3 PF13014.1 AMD21896.1 - 1.4e-10 40.5 5.4 3.5e-05 23.3 0.0 4.5 5 0 0 5 5 5 3 KH domain Pilt PF15453.1 AMD21897.1 - 0.081 12.5 6.0 0.13 11.9 4.2 1.3 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions DUF2052 PF09747.4 AMD21897.1 - 0.17 11.7 16.9 0.019 14.9 7.6 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF607 PF04678.8 AMD21897.1 - 1 9.2 4.7 5.1 6.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF607 Peptidase_S49_N PF08496.5 AMD21897.1 - 1.7 8.3 9.9 2.9 7.6 4.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TEX19 PF15553.1 AMD21897.1 - 2.5 7.9 6.1 5.3 6.8 4.2 1.5 1 0 0 1 1 1 0 Testis-expressed protein 19 CCDC66 PF15236.1 AMD21897.1 - 3 7.4 28.6 0.11 12.1 14.0 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 ChaC PF04752.7 AMD21898.1 - 1.3e-48 165.2 0.0 1.9e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 ChaC-like protein GDI PF00996.13 AMD21899.1 - 2.5e-214 711.5 0.6 2.9e-214 711.3 0.4 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.1 AMD21899.1 - 0.019 14.9 0.0 0.045 13.7 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain LSM PF01423.17 AMD21900.1 - 8e-16 57.3 0.2 1.1e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 AMD21900.1 - 0.12 12.2 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain Bacillus_HBL PF05791.6 AMD21901.1 - 0.028 13.7 1.2 0.036 13.4 0.8 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DCD PF06559.6 AMD21901.1 - 0.048 12.0 0.0 0.048 12.0 0.0 1.2 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) CENP-N PF05238.8 AMD21901.1 - 0.067 12.2 1.2 0.072 12.1 0.8 1.0 1 0 0 1 1 1 0 Kinetochore protein CHL4 like zf-CCHC_4 PF14392.1 AMD21901.1 - 0.078 12.6 1.1 0.16 11.6 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.18 AMD21901.1 - 0.18 11.8 1.1 0.28 11.1 0.8 1.3 1 0 0 1 1 1 0 Zinc knuckle UAF_Rrn10 PF05234.6 AMD21902.1 - 1.1e-31 109.3 0.0 1.2e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Nol1_Nop2_Fmu PF01189.12 AMD21903.1 - 3.2e-70 236.7 0.0 1.7e-54 185.1 0.0 2.2 1 1 1 2 2 2 2 NOL1/NOP2/sun family FtsJ PF01728.14 AMD21903.1 - 0.0037 17.2 0.0 0.0092 15.9 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 AMD21903.1 - 0.016 15.8 0.0 0.075 13.6 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_26 PF13659.1 AMD21903.1 - 0.066 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MCM PF00493.18 AMD21904.1 - 7.1e-141 468.7 0.1 9.7e-141 468.3 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM2_N PF12619.3 AMD21904.1 - 3.3e-28 98.6 28.4 3.3e-28 98.6 19.7 3.5 4 0 0 4 4 4 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 AMD21904.1 - 2.3e-15 57.1 0.1 5.7e-15 55.8 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 AMD21904.1 - 1.9e-09 36.9 0.0 2e-07 30.3 0.0 2.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 AMD21904.1 - 2e-07 30.8 0.0 4.4e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 AMD21904.1 - 0.00084 18.9 0.0 0.0036 16.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 AMD21904.1 - 0.0014 18.1 0.1 0.01 15.3 0.1 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.24 AMD21904.1 - 0.013 15.7 0.0 0.036 14.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Yippee-Mis18 PF03226.9 AMD21904.1 - 0.14 12.2 0.1 0.45 10.5 0.0 1.8 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-UBR PF02207.15 AMD21905.1 - 3.4e-15 55.5 12.9 3.4e-15 55.5 9.0 2.7 3 1 1 4 4 4 1 Putative zinc finger in N-recognin (UBR box) DUF1572 PF07609.6 AMD21905.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1572) DUF747 PF05346.6 AMD21906.1 - 1.5e-95 320.0 17.1 2.2e-95 319.5 11.8 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family HPD PF05044.7 AMD21906.1 - 0.059 13.0 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Homeo-prospero domain RPAP2_Rtr1 PF04181.8 AMD21907.1 - 3.5e-18 65.4 0.3 5.6e-18 64.8 0.2 1.3 1 0 0 1 1 1 1 Rtr1/RPAP2 family PLDc_2 PF13091.1 AMD21909.1 - 9.7e-17 60.8 0.1 3.7e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 AMD21909.1 - 4.2e-08 32.7 1.1 0.0025 17.5 0.0 3.0 2 1 0 2 2 2 2 Phospholipase D Active site motif Rer1 PF03248.8 AMD21910.1 - 2.2e-75 252.0 5.7 2.6e-75 251.9 4.0 1.0 1 0 0 1 1 1 1 Rer1 family ABC_membrane PF00664.18 AMD21910.1 - 0.15 11.4 2.1 0.21 10.9 0.0 1.9 2 0 0 2 2 2 0 ABC transporter transmembrane region eRF1_2 PF03464.10 AMD21911.1 - 2.6e-29 102.2 0.1 4.2e-29 101.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 AMD21911.1 - 1.1e-25 90.0 0.2 6.2e-25 87.6 0.0 2.3 2 1 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.10 AMD21911.1 - 9e-14 51.1 0.4 1.4e-13 50.5 0.3 1.3 1 0 0 1 1 1 1 eRF1 domain 1 SRP1_TIP1 PF00660.12 AMD21911.1 - 0.032 14.0 0.1 0.33 10.7 0.0 2.4 2 0 0 2 2 2 0 Seripauperin and TIP1 family Septin PF00735.13 AMD21912.1 - 6.2e-107 356.8 2.7 7.3e-107 356.5 1.9 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 AMD21912.1 - 1e-09 38.3 0.2 1.6e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD21912.1 - 9.5e-08 31.6 0.8 1.9e-06 27.4 0.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.11 AMD21912.1 - 1.1e-06 27.9 0.6 3.5e-06 26.2 0.4 1.9 1 1 0 1 1 1 1 AIG1 family DUF258 PF03193.11 AMD21912.1 - 2e-06 27.0 0.0 3.6e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 AMD21912.1 - 5.4e-06 26.3 1.7 0.0062 16.3 0.3 2.5 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 AMD21912.1 - 0.00086 19.7 1.0 0.0023 18.4 0.2 2.0 1 1 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 AMD21912.1 - 0.00088 19.3 0.1 0.0035 17.3 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 AMD21912.1 - 0.0011 18.8 0.5 0.035 13.9 0.8 2.9 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 AMD21912.1 - 0.0016 17.9 0.1 0.0035 16.8 0.0 1.4 1 1 0 1 1 1 1 AAA-like domain AAA_23 PF13476.1 AMD21912.1 - 0.0021 18.4 1.3 0.0088 16.3 0.4 1.8 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.22 AMD21912.1 - 0.0027 18.0 1.0 0.0059 16.9 0.7 1.7 1 1 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.13 AMD21912.1 - 0.0049 16.3 0.1 0.014 14.8 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.1 AMD21912.1 - 0.0058 16.1 0.0 0.038 13.5 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_24 PF13479.1 AMD21912.1 - 0.0068 16.0 0.5 0.02 14.5 0.4 1.9 1 1 0 1 1 1 1 AAA domain IIGP PF05049.8 AMD21912.1 - 0.011 14.5 0.0 0.017 13.9 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.1 AMD21912.1 - 0.012 15.7 0.1 0.028 14.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 AMD21912.1 - 0.025 14.2 0.0 0.057 13.1 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 AMD21912.1 - 0.027 13.8 0.0 0.061 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 AMD21912.1 - 0.033 14.0 0.1 0.14 12.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.17 AMD21912.1 - 0.046 12.5 0.4 0.081 11.7 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain PduV-EutP PF10662.4 AMD21912.1 - 0.053 13.0 0.1 0.93 8.9 0.0 2.7 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 AMD21912.1 - 0.058 12.2 0.1 0.14 11.0 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.17 AMD21912.1 - 0.075 13.2 0.1 0.21 11.8 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_28 PF13521.1 AMD21912.1 - 0.079 12.9 0.3 1.5 8.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.1 AMD21912.1 - 0.1 13.3 0.5 0.29 11.9 0.2 2.0 1 1 0 1 1 1 0 AAA domain Ribosomal_L32p PF01783.18 AMD21913.1 - 7e-11 42.1 6.0 7e-11 42.1 4.1 1.6 2 0 0 2 2 2 1 Ribosomal L32p protein family Elongin_A PF06881.6 AMD21913.1 - 0.0042 17.4 2.7 0.0066 16.8 1.9 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF2930 PF11152.3 AMD21913.1 - 0.063 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2930) zf-FPG_IleRS PF06827.9 AMD21913.1 - 0.5 10.0 4.4 1.5 8.5 3.1 1.7 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS Cupin_8 PF13621.1 AMD21914.1 - 3e-13 49.8 0.2 6.1e-13 48.8 0.1 1.4 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 AMD21914.1 - 3e-10 40.3 0.1 1.5e-09 38.1 0.1 2.3 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.2 AMD21914.1 - 5.1e-06 26.1 0.1 2e-05 24.2 0.0 2.1 1 0 0 1 1 1 1 F-box-like Cupin_2 PF07883.6 AMD21914.1 - 0.0033 16.9 0.0 0.021 14.3 0.0 2.2 2 0 0 2 2 2 1 Cupin domain F-box-like_2 PF13013.1 AMD21914.1 - 0.04 13.6 0.5 1.1 8.9 0.0 3.1 3 1 0 3 3 3 0 F-box-like domain Citrate_synt PF00285.16 AMD21915.1 - 8.2e-101 337.2 0.0 1e-100 336.9 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase SH3BGR PF04908.10 AMD21917.1 - 4.6e-05 23.2 0.0 0.00026 20.9 0.0 2.2 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.19 AMD21917.1 - 0.0002 21.2 0.0 0.00046 20.1 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin Glycogen_syn PF05693.8 AMD21919.1 - 0 1065.0 0.0 0 1064.8 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.15 AMD21919.1 - 8.9e-10 38.2 0.0 4.1e-06 26.3 0.0 2.6 2 1 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 AMD21919.1 - 1.7e-05 25.0 1.6 4.8e-05 23.5 1.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.6 AMD21919.1 - 5.5e-05 22.7 0.3 9.8e-05 21.9 0.2 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Pkinase PF00069.20 AMD21920.1 - 4.8e-73 245.5 0.0 6.5e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD21920.1 - 5.5e-43 146.9 0.0 1.4e-42 145.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD21920.1 - 0.00016 20.7 0.0 0.021 13.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 AMD21920.1 - 0.0039 16.2 0.0 0.0067 15.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD21920.1 - 0.14 11.8 0.1 0.36 10.5 0.0 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family bZIP_2 PF07716.10 AMD21921.1 - 6.5e-08 32.2 11.4 6.5e-08 32.2 7.9 3.4 2 1 2 4 4 4 2 Basic region leucine zipper bZIP_1 PF00170.16 AMD21921.1 - 0.00074 19.4 19.8 0.0028 17.5 9.6 3.3 2 1 1 3 3 3 1 bZIP transcription factor bZIP_Maf PF03131.12 AMD21921.1 - 0.85 9.9 17.0 0.31 11.3 8.9 2.2 1 1 1 2 2 2 0 bZIP Maf transcription factor Mto2_bdg PF12808.2 AMD21921.1 - 5.9 7.0 21.7 1.8 8.7 0.2 2.8 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF972 PF06156.8 AMD21921.1 - 6.6 7.1 10.9 2.2 8.6 4.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Proteasome PF00227.21 AMD21923.1 - 1.3e-56 190.9 0.0 1.7e-56 190.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 AMD21923.1 - 7.2e-13 47.5 0.0 1.6e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TOM13 PF08219.6 AMD21924.1 - 4.4e-26 90.4 0.3 8e-26 89.6 0.2 1.6 1 1 0 1 1 1 1 Outer membrane protein TOM13 Rpr2 PF04032.11 AMD21925.1 - 1.2e-17 63.4 1.1 1.8e-17 62.9 0.7 1.3 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-CDGSH PF09360.5 AMD21925.1 - 0.0067 16.2 0.2 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type zf-CSL PF05207.8 AMD21925.1 - 0.11 12.0 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 CSL zinc finger DUF1746 PF08508.5 AMD21926.1 - 0.042 13.7 4.9 0.088 12.7 3.4 1.5 1 1 0 1 1 1 0 Fungal domain of unknown function (DUF1746) LETM1 PF07766.8 AMD21927.1 - 2.6e-100 334.9 5.6 4.2e-100 334.2 3.9 1.3 1 0 0 1 1 1 1 LETM1-like protein Cellulase PF00150.13 AMD21928.1 - 3.6e-12 46.0 0.0 6e-07 28.9 0.0 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) DNA_primase_S PF01896.14 AMD21929.1 - 2.4e-53 179.8 0.5 4.4e-53 178.9 0.3 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Proteasome PF00227.21 AMD21930.1 - 4.7e-39 133.6 0.0 5.5e-39 133.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit HA2 PF04408.18 AMD21931.1 - 7e-28 96.6 0.0 2.7e-27 94.7 0.0 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 AMD21931.1 - 7e-24 83.8 0.0 1.8e-23 82.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.18 AMD21931.1 - 1.7e-14 53.6 0.2 4.1e-14 52.4 0.1 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.26 AMD21931.1 - 7.8e-13 48.1 0.2 4.7e-12 45.5 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 AMD21931.1 - 6.8e-06 26.2 0.1 3.8e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain DEAD PF00270.24 AMD21931.1 - 2e-05 24.1 0.2 5.4e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.1 AMD21931.1 - 0.00032 20.3 0.0 0.00073 19.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 AMD21931.1 - 0.002 17.1 0.1 0.014 14.3 0.0 2.2 2 1 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.22 AMD21931.1 - 0.0046 17.2 5.4 0.052 13.8 0.3 3.4 2 1 0 2 2 2 1 ABC transporter AAA_14 PF13173.1 AMD21931.1 - 0.0067 16.3 0.5 0.054 13.3 0.1 2.6 2 1 0 2 2 2 1 AAA domain KaiC PF06745.8 AMD21931.1 - 0.0095 15.0 0.1 0.19 10.7 0.0 2.4 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.1 AMD21931.1 - 0.022 14.1 0.0 0.061 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 AMD21931.1 - 0.034 14.6 0.1 0.19 12.2 0.0 2.3 1 0 0 1 1 1 0 Miro-like protein SRP54 PF00448.17 AMD21931.1 - 0.044 13.2 0.1 0.13 11.7 0.0 1.8 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.1 AMD21931.1 - 0.05 13.6 0.1 0.52 10.3 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain PWI PF01480.12 AMD21931.1 - 0.13 12.4 0.9 1.6 8.9 0.2 2.7 2 0 0 2 2 2 0 PWI domain AAA_29 PF13555.1 AMD21931.1 - 0.2 11.2 0.0 0.5 9.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NAD_binding_8 PF13450.1 AMD21932.1 - 1.6e-09 37.6 0.0 6.7e-09 35.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 AMD21932.1 - 1.5e-06 27.5 0.0 5.8e-06 25.6 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 AMD21932.1 - 2.6e-06 26.5 0.0 1.3e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 AMD21932.1 - 8.4e-05 22.8 0.0 0.0035 17.7 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 AMD21932.1 - 0.00075 18.6 0.0 0.0046 16.0 0.0 2.0 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 AMD21932.1 - 0.015 15.1 0.0 0.037 13.9 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.10 AMD21932.1 - 0.016 13.3 0.0 0.033 12.3 0.0 1.4 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Pyr_redox_3 PF13738.1 AMD21932.1 - 0.039 14.0 0.0 0.41 10.6 0.0 2.4 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Beta_helix PF13229.1 AMD21932.1 - 0.2 11.4 3.6 0.15 11.8 1.0 1.9 2 0 0 2 2 2 0 Right handed beta helix region RRM_5 PF13893.1 AMD21933.1 - 9.1e-13 47.8 0.0 1.4e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD21933.1 - 1.8e-09 37.1 0.1 3e-09 36.3 0.1 1.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD21933.1 - 9.9e-09 35.0 0.1 1.9e-08 34.1 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 AMD21933.1 - 0.00046 19.8 0.0 0.0006 19.5 0.0 1.2 1 0 0 1 1 1 1 Limkain b1 Ubiquitin_2 PF14560.1 AMD21933.1 - 0.056 13.7 0.0 0.079 13.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain EB1 PF03271.12 AMD21934.1 - 5.1e-18 64.8 0.8 1.1e-17 63.7 0.6 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 AMD21934.1 - 2.7e-05 24.1 1.2 7.1e-05 22.8 0.8 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain SlyX PF04102.7 AMD21934.1 - 0.0016 18.7 1.6 0.0043 17.4 1.1 1.7 1 0 0 1 1 1 1 SlyX DUF869 PF05911.6 AMD21934.1 - 0.0019 16.5 0.6 0.0029 15.9 0.4 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) DUF1202 PF06717.6 AMD21934.1 - 0.0022 17.3 0.2 0.0039 16.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1202) HR1 PF02185.11 AMD21934.1 - 0.026 14.2 1.5 0.066 12.9 1.0 1.6 1 0 0 1 1 1 0 Hr1 repeat Apc15p PF05841.6 AMD21934.1 - 1.9 9.2 7.0 14 6.4 4.8 2.1 1 1 0 1 1 1 0 Apc15p protein Peptidase_M41 PF01434.13 AMD21935.1 - 1.2e-73 247.0 0.0 1.8e-73 246.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 AMD21935.1 - 1.2e-41 142.0 0.0 3.4e-41 140.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 AMD21935.1 - 0.00066 20.4 0.0 0.003 18.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain FtsH_ext PF06480.10 AMD21935.1 - 0.0015 18.6 0.0 0.0047 17.0 0.0 1.9 1 0 0 1 1 1 1 FtsH Extracellular IstB_IS21 PF01695.12 AMD21935.1 - 0.0021 17.5 0.1 0.0077 15.6 0.0 1.9 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.9 AMD21935.1 - 0.0026 17.4 0.1 0.012 15.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 AMD21935.1 - 0.0027 17.4 0.4 0.0072 16.0 0.3 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 AMD21935.1 - 0.0049 17.0 1.0 0.12 12.4 0.1 2.7 2 1 0 3 3 2 1 AAA domain TIP49 PF06068.8 AMD21935.1 - 0.0067 15.1 0.0 0.012 14.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_25 PF13481.1 AMD21935.1 - 0.012 15.0 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 AMD21935.1 - 0.021 14.7 0.0 0.053 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.7 AMD21935.1 - 0.024 13.6 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 AMD21935.1 - 0.029 13.4 0.0 0.055 12.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_2 PF07724.9 AMD21935.1 - 0.056 13.3 0.0 0.23 11.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.16 AMD21935.1 - 0.16 11.0 0.1 0.34 10.0 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI HMG_box PF00505.14 AMD21936.1 - 4.4e-14 52.5 6.0 6.3e-13 48.7 4.2 2.2 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 AMD21936.1 - 4.1e-05 23.8 1.9 0.0001 22.6 1.3 1.7 1 1 0 1 1 1 1 HMG-box domain Ribosomal_S5 PF00333.15 AMD21937.1 - 9.3e-25 86.1 0.0 1.5e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 AMD21937.1 - 9.7e-20 69.6 0.0 1.6e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain SURF1 PF02104.10 AMD21938.1 - 6e-63 212.5 0.0 7.8e-63 212.1 0.0 1.1 1 0 0 1 1 1 1 SURF1 family Ig_2 PF13895.1 AMD21938.1 - 0.013 15.6 0.0 0.032 14.3 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.12 AMD21938.1 - 0.051 13.4 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain DASH_Dam1 PF08653.5 AMD21939.1 - 1.1e-29 101.9 0.9 2.4e-29 100.8 0.6 1.6 1 0 0 1 1 1 1 DASH complex subunit Dam1 Suppressor_APC PF11414.3 AMD21939.1 - 0.057 13.2 1.2 0.31 10.8 0.5 2.2 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein Ctr PF04145.10 AMD21940.1 - 1.9e-28 99.3 2.0 1.9e-28 99.3 1.4 1.6 2 0 0 2 2 2 1 Ctr copper transporter family Fijivirus_P9-2 PF06837.6 AMD21940.1 - 9.1 5.3 7.6 2.5 7.1 2.8 1.7 2 0 0 2 2 2 0 Fijivirus P9-2 protein SH2_2 PF14633.1 AMD21941.1 - 1.4e-100 334.9 3.2 1.4e-100 334.9 2.2 2.2 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.1 AMD21941.1 - 7e-59 197.7 0.2 2.8e-58 195.7 0.1 2.1 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 DLD PF14878.1 AMD21941.1 - 9.4e-48 161.0 4.7 9.4e-48 161.0 3.2 4.0 3 0 0 3 3 3 1 Death-like domain of SPT6 HHH_7 PF14635.1 AMD21941.1 - 2.6e-40 136.7 0.0 1e-39 134.8 0.0 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.1 AMD21941.1 - 4.7e-35 120.2 3.2 4.7e-35 120.2 2.2 3.0 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.1 AMD21941.1 - 7.4e-23 80.5 17.7 7.4e-23 80.5 12.3 4.4 4 0 0 4 4 4 2 Acidic N-terminal SPT6 SH2 PF00017.19 AMD21941.1 - 1.1e-11 44.3 0.0 4.4e-11 42.4 0.0 2.1 1 0 0 1 1 1 1 SH2 domain WHG PF13305.1 AMD21941.1 - 0.036 14.6 0.2 8.9 6.9 0.2 3.2 2 0 0 2 2 2 0 WHG domain LETM1 PF07766.8 AMD21942.1 - 1.4e-101 339.0 2.0 1.4e-101 339.0 1.4 1.7 2 0 0 2 2 2 1 LETM1-like protein RNA_pol_3_Rpc31 PF11705.3 AMD21942.1 - 0.086 12.7 8.2 0.63 9.9 0.1 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 CCDC71L PF15374.1 AMD21942.1 - 0.17 11.1 5.7 0.082 12.2 2.0 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 71L tRNA-synt_1 PF00133.17 AMD21943.1 - 1.2e-226 753.4 0.0 1.2e-226 753.4 0.0 2.2 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 AMD21943.1 - 4.3e-33 114.2 2.0 4.3e-33 114.2 1.4 2.7 3 0 0 3 3 3 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 AMD21943.1 - 2e-18 66.2 0.1 9.7e-10 37.6 0.0 4.4 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 AMD21943.1 - 3.9e-09 36.0 0.0 1.6e-07 30.7 0.0 4.0 4 1 1 5 5 5 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.14 AMD21943.1 - 0.17 10.9 6.4 1.2 8.1 0.0 3.4 3 1 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.16 AMD21943.1 - 3.9 6.0 9.8 1.6 7.3 0.0 3.4 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain Bud13 PF09736.4 AMD21943.1 - 5.8 7.1 17.0 0.27 11.4 5.5 2.6 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex RNase_PH PF01138.16 AMD21944.1 - 1.5e-15 57.6 0.0 2.5e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 AMD21944.1 - 2.7e-05 24.0 0.0 4.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Mito_carr PF00153.22 AMD21945.1 - 1.3e-61 204.3 2.6 1.4e-23 82.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1914 PF08932.5 AMD21945.1 - 0.042 13.8 0.8 0.34 10.9 0.0 2.6 2 2 1 3 3 3 0 Domain of unknown function (DUF1914) Romo1 PF10247.4 AMD21945.1 - 0.078 13.1 0.8 2.5 8.3 0.2 2.7 1 1 1 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 ABC2_membrane_5 PF13346.1 AMD21945.1 - 0.16 11.2 3.6 0.63 9.2 0.1 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein CDP-OH_P_transf PF01066.16 AMD21946.1 - 1.4e-19 70.2 1.9 1.4e-19 70.2 1.3 1.6 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CBF PF03914.12 AMD21947.1 - 1.4e-45 154.6 0.2 3e-45 153.6 0.1 1.6 1 0 0 1 1 1 1 CBF/Mak21 family Lipase_GDSL_3 PF14606.1 AMD21947.1 - 0.1 12.3 0.0 0.3 10.7 0.0 1.8 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Asn_synthase PF00733.16 AMD21948.1 - 2.5e-70 236.8 0.0 3.3e-70 236.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 AMD21948.1 - 5.2e-34 116.6 0.0 8.9e-34 115.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 AMD21948.1 - 2e-27 95.7 0.0 4.5e-27 94.6 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_2 PF00310.16 AMD21948.1 - 0.00026 19.8 0.0 0.023 13.3 0.0 2.4 1 1 1 2 2 2 2 Glutamine amidotransferases class-II DUF3700 PF12481.3 AMD21948.1 - 0.00071 18.8 0.0 0.0012 18.0 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.12 AMD21948.1 - 0.0032 16.4 0.0 0.0061 15.4 0.0 1.6 1 1 0 1 1 1 1 NAD synthase GTP_cyclohydroI PF01227.17 AMD21949.1 - 2.9e-74 248.2 0.3 3.4e-74 247.9 0.2 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 AMD21949.1 - 0.00024 20.9 0.0 0.00067 19.5 0.0 1.7 1 0 0 1 1 1 1 QueF-like protein DUF2703 PF10865.3 AMD21949.1 - 0.0086 16.0 0.5 2.4 8.1 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF2703) DnaJ_CXXCXGXG PF00684.14 AMD21950.1 - 0.00032 20.6 9.3 0.0041 17.1 1.1 2.4 2 0 0 2 2 2 2 DnaJ central domain HypA PF01155.14 AMD21950.1 - 0.042 13.5 1.2 3.6 7.3 0.1 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 AMD21950.1 - 4.9 7.1 9.7 0.39 10.7 0.3 3.0 2 1 1 3 3 3 0 Zinc ribbon domain zf-RING_5 PF14634.1 AMD21950.1 - 5.4 6.8 9.2 5.7 6.7 0.4 2.8 2 1 1 3 3 3 0 zinc-RING finger domain Got1 PF04178.7 AMD21951.1 - 4.2e-20 72.0 13.3 4.9e-20 71.8 9.2 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family DUF973 PF06157.6 AMD21951.1 - 5.6e-05 22.2 3.5 6.9e-05 21.9 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF973) DUF4401 PF14351.1 AMD21951.1 - 0.0017 17.3 5.2 0.0017 17.3 3.6 1.9 1 1 0 2 2 2 1 Domain of unknown function (DUF4401) DUF373 PF04123.8 AMD21951.1 - 0.42 9.5 2.0 0.48 9.4 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF872 PF05915.7 AMD21951.1 - 2.2 8.1 7.8 0.47 10.3 1.0 2.3 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) YrhK PF14145.1 AMD21951.1 - 3 7.5 10.9 1.1 8.9 2.2 2.7 1 1 1 2 2 2 0 YrhK-like protein PEMT PF04191.8 AMD21951.1 - 9.2 6.4 8.9 1.1 9.3 0.6 2.6 2 1 0 2 2 2 0 Phospholipid methyltransferase AAA PF00004.24 AMD21952.1 - 3.6e-51 172.8 0.0 2.3e-42 144.3 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 AMD21952.1 - 1.1e-08 35.2 0.7 3.1e-05 23.9 0.0 3.9 4 0 0 4 4 4 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 AMD21952.1 - 2.2e-07 31.0 0.1 7.4e-05 22.8 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 AMD21952.1 - 1.6e-06 27.6 0.0 0.00012 21.5 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.1 AMD21952.1 - 2.6e-06 27.5 0.0 0.1 12.6 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.9 AMD21952.1 - 2.5e-05 24.0 0.0 0.0002 21.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 AMD21952.1 - 4.2e-05 23.0 0.0 0.49 9.8 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 AMD21952.1 - 0.00014 22.0 1.0 0.0045 17.1 0.1 3.2 2 2 0 2 2 2 1 AAA domain Bromodomain PF00439.20 AMD21952.1 - 0.00032 20.5 0.0 0.0011 18.7 0.0 1.9 1 0 0 1 1 1 1 Bromodomain AAA_17 PF13207.1 AMD21952.1 - 0.00035 21.3 5.0 0.043 14.6 0.0 4.3 4 0 0 4 4 3 1 AAA domain T2SE PF00437.15 AMD21952.1 - 0.00089 18.2 0.0 0.18 10.6 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_14 PF13173.1 AMD21952.1 - 0.0012 18.7 0.0 0.018 14.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 AMD21952.1 - 0.0013 18.4 0.0 0.013 15.2 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain TIP49 PF06068.8 AMD21952.1 - 0.0039 15.9 0.0 0.021 13.5 0.0 1.9 2 0 0 2 2 2 1 TIP49 C-terminus AAA_25 PF13481.1 AMD21952.1 - 0.0045 16.4 0.1 0.016 14.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 AMD21952.1 - 0.0065 16.3 3.0 0.023 14.5 0.0 3.1 3 1 0 3 3 2 1 Type III restriction enzyme, res subunit AAA_33 PF13671.1 AMD21952.1 - 0.0099 15.7 0.0 0.03 14.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 AMD21952.1 - 0.011 16.0 2.5 0.034 14.4 0.0 3.1 3 0 0 3 3 3 0 ABC transporter RNA_helicase PF00910.17 AMD21952.1 - 0.012 15.7 0.0 0.043 14.0 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.12 AMD21952.1 - 0.014 14.2 0.0 0.49 9.2 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Mg_chelatase PF01078.16 AMD21952.1 - 0.018 14.2 0.1 0.098 11.7 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PhoH PF02562.11 AMD21952.1 - 0.023 13.9 0.0 0.089 12.0 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.6 AMD21952.1 - 0.037 13.6 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AMD21952.1 - 0.039 12.9 0.0 0.087 11.8 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_30 PF13604.1 AMD21952.1 - 0.054 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Amidase PF01425.16 AMD21953.1 - 1.6e-113 379.8 0.0 2e-113 379.6 0.0 1.0 1 0 0 1 1 1 1 Amidase Dynamitin PF04912.9 AMD21954.1 - 2.2e-15 56.3 10.9 2.2e-15 56.3 7.5 2.6 1 1 0 2 2 2 1 Dynamitin Laminin_II PF06009.7 AMD21954.1 - 0.0033 17.2 1.7 0.0033 17.2 1.2 4.1 3 1 1 4 4 4 1 Laminin Domain II Latarcin PF10279.4 AMD21954.1 - 0.0062 16.7 0.1 4.1 7.6 0.5 3.6 2 2 0 2 2 2 1 Latarcin precursor Glyco_hydro_42C PF08533.5 AMD21954.1 - 0.11 12.0 0.0 0.3 10.6 0.0 1.7 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain Noelin-1 PF12308.3 AMD21954.1 - 0.11 12.2 5.3 0.83 9.4 0.7 2.9 2 0 0 2 2 2 0 Neurogenesis glycoprotein DUF1664 PF07889.7 AMD21954.1 - 0.72 9.6 13.2 0.69 9.7 0.3 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DASH_Duo1 PF08651.5 AMD21954.1 - 1.7 8.3 8.1 0.14 11.7 0.4 3.1 3 1 1 4 4 4 0 DASH complex subunit Duo1 Hpt PF01627.18 AMD21954.1 - 2.1 8.4 5.7 3.8 7.5 0.0 3.2 3 1 0 3 3 3 0 Hpt domain Osmo_CC PF08946.5 AMD21954.1 - 2.9 7.9 13.0 6.1 6.9 1.5 3.6 3 0 0 3 3 3 0 Osmosensory transporter coiled coil Baculo_PEP_C PF04513.7 AMD21954.1 - 4.8 7.0 9.1 1.5 8.6 0.2 3.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus AKNA PF12443.3 AMD21954.1 - 6.3 6.8 9.6 15 5.7 0.1 3.3 2 1 1 3 3 3 0 AT-hook-containing transcription factor DUF948 PF06103.6 AMD21954.1 - 6.4 6.7 9.2 2.3 8.1 0.1 4.0 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Sec63 PF02889.11 AMD21955.1 - 3.9e-136 453.3 0.3 2.3e-90 303.0 0.0 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 AMD21955.1 - 3.7e-55 185.9 3.3 5.9e-28 97.4 0.7 4.5 6 0 0 6 6 6 2 DEAD/DEAH box helicase ResIII PF04851.10 AMD21955.1 - 4.7e-21 75.4 0.0 4.3e-09 36.4 0.0 2.7 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 AMD21955.1 - 7e-21 73.8 0.0 2.1e-09 37.1 0.0 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain SNF2_N PF00176.18 AMD21955.1 - 8.5e-07 28.0 0.6 0.0025 16.6 0.1 2.6 2 0 0 2 2 2 2 SNF2 family N-terminal domain PhoH PF02562.11 AMD21955.1 - 4.5e-06 26.0 0.1 0.026 13.7 0.0 3.3 3 0 0 3 3 3 2 PhoH-like protein AAA PF00004.24 AMD21955.1 - 2.3e-05 24.6 1.3 0.095 12.9 0.0 3.9 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 AMD21955.1 - 0.00072 19.0 0.3 1.5 8.2 0.0 4.0 4 0 0 4 4 4 1 IstB-like ATP binding protein T2SE PF00437.15 AMD21955.1 - 0.0063 15.4 0.0 2.4 6.9 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_10 PF12846.2 AMD21955.1 - 0.041 13.3 0.5 27 4.0 0.1 3.7 2 2 1 4 4 4 0 AAA-like domain Zeta_toxin PF06414.7 AMD21955.1 - 0.11 11.5 0.0 8.7 5.3 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin DUF2361 PF10153.4 AMD21956.1 - 7.3e-35 119.6 11.1 1.3e-34 118.8 7.7 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2361) DASH_Dad3 PF08656.5 AMD21956.1 - 0.073 12.7 0.2 0.29 10.8 0.0 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad3 TRAP-delta PF05404.7 AMD21956.1 - 0.076 12.4 0.2 9.5 5.6 0.0 2.2 1 1 0 2 2 2 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) VanY PF02557.12 AMD21956.1 - 0.1 12.4 0.3 4.3 7.2 0.0 2.2 1 1 1 2 2 2 0 D-alanyl-D-alanine carboxypeptidase DUF2937 PF11157.3 AMD21956.1 - 0.16 11.3 2.4 6.1 6.1 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2937) DUF2406 PF10295.4 AMD21957.1 - 2.7e-24 85.4 0.1 5.3e-24 84.5 0.1 1.5 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) Aminotran_1_2 PF00155.16 AMD21958.1 - 6.2e-62 209.6 0.1 7.5e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_S10 PF00450.17 AMD21959.1 - 7.9e-132 440.3 0.5 9.6e-132 440.0 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.6 AMD21959.1 - 1.4e-09 38.0 0.1 4.3e-09 36.5 0.1 1.8 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide Abhydrolase_6 PF12697.2 AMD21959.1 - 0.0018 18.2 0.0 0.0093 15.8 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF3591 PF12157.3 AMD21961.1 - 3.4e-199 661.9 2.2 6.6e-199 661.0 1.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.1 AMD21961.1 - 8.2e-08 31.7 0.8 2.1e-07 30.4 0.6 1.6 1 0 0 1 1 1 1 Zinc knuckle PcfK PF14058.1 AMD21961.1 - 0.9 9.6 12.5 0.62 10.2 2.6 3.4 3 0 0 3 3 3 0 PcfK-like protein Rtt102p PF09510.5 AMD21962.1 - 5.4e-22 78.1 0.3 5.4e-22 78.1 0.2 2.6 2 1 0 2 2 2 1 Rtt102p-like transcription regulator protein Pex14_N PF04695.8 AMD21962.1 - 0.19 11.7 1.7 0.4 10.7 1.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RNase_T PF00929.19 AMD21963.1 - 8.8e-26 91.1 0.1 1.8e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DUF3682 PF12446.3 AMD21963.1 - 1.2 9.4 7.3 0.5 10.6 3.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) GATase_2 PF00310.16 AMD21965.1 - 9.2e-24 83.8 0.0 7.2e-18 64.4 0.0 2.3 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 AMD21965.1 - 5.4e-16 58.7 0.0 1.2e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 AMD21965.1 - 7.4e-15 54.7 0.0 1.5e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 AMD21965.1 - 6.9e-12 45.1 0.2 1.2e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 AMD21965.1 - 2.6e-05 23.0 0.0 4.4e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II ABC_membrane PF00664.18 AMD21966.1 - 1.7e-35 122.7 18.2 2.6e-35 122.1 12.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 AMD21966.1 - 2.8e-35 121.6 0.4 6.8e-35 120.3 0.0 1.9 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.14 AMD21966.1 - 5.7e-10 38.8 0.2 7.3e-07 28.6 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 AMD21966.1 - 1.3e-06 28.5 0.4 0.0064 16.4 0.2 3.3 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.1 AMD21966.1 - 0.00026 20.4 0.2 0.00068 19.1 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 AMD21966.1 - 0.00036 19.7 0.0 0.00079 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_ATPase PF09818.4 AMD21966.1 - 0.00063 18.4 0.9 0.0047 15.5 0.1 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_17 PF13207.1 AMD21966.1 - 0.005 17.6 0.0 0.0097 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATP-synt_ab PF00006.20 AMD21966.1 - 0.011 15.1 0.1 0.14 11.6 0.0 2.2 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.1 AMD21966.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.1 AMD21966.1 - 0.014 14.7 0.0 0.038 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 AMD21966.1 - 0.026 14.6 0.0 0.091 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.8 AMD21966.1 - 0.027 13.3 0.0 0.058 12.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_14 PF13173.1 AMD21966.1 - 0.041 13.7 0.1 0.15 11.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 AMD21966.1 - 0.096 13.0 4.7 0.76 10.0 3.3 2.4 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 AMD21966.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Proteasome PF00227.21 AMD21967.1 - 8.1e-48 162.2 0.1 9.9e-48 161.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 AMD21967.1 - 1e-12 47.0 0.2 1.9e-12 46.2 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature AFOR_N PF02730.10 AMD21967.1 - 0.13 11.5 0.2 0.4 9.9 0.0 1.8 2 0 0 2 2 2 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain DUF3336 PF11815.3 AMD21968.1 - 1.3e-27 96.0 0.0 2.6e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 AMD21968.1 - 5.3e-08 33.0 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase URO-D PF01208.12 AMD21969.1 - 0.082 11.8 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) DnaJ PF00226.26 AMD21970.1 - 1.1e-16 60.2 0.2 1.1e-16 60.2 0.2 2.3 2 1 0 2 2 2 1 DnaJ domain Sec62 PF03839.11 AMD21970.1 - 2.7 7.3 18.6 1.5 8.1 11.3 1.7 1 1 0 1 1 1 0 Translocation protein Sec62 PLRV_ORF5 PF01690.12 AMD21970.1 - 6.8 5.7 18.1 1.8 7.6 10.2 1.5 2 0 0 2 2 2 0 Potato leaf roll virus readthrough protein SURF4 PF02077.10 AMD21971.1 - 3.9e-96 321.5 12.3 4.5e-96 321.3 8.5 1.0 1 0 0 1 1 1 1 SURF4 family IPP-2 PF04979.9 AMD21972.1 - 7e-09 36.0 3.8 7e-09 36.0 2.7 1.9 1 1 1 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Methyltrn_RNA_3 PF02598.12 AMD21973.1 - 1.2e-88 297.2 0.0 1.7e-88 296.7 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methyltransferase Plasmid_stab_B PF10784.4 AMD21973.1 - 0.065 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Plasmid stability protein DUF381 PF04038.7 AMD21973.1 - 0.092 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF381) CC PF04942.9 AMD21973.1 - 0.14 12.0 0.8 0.28 11.1 0.6 1.4 1 0 0 1 1 1 0 CC domain Glyco_hydro_17 PF00332.13 AMD21974.1 - 1.8e-55 188.1 0.0 2.2e-55 187.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 DUF2895 PF11444.3 AMD21974.1 - 0.026 13.7 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) Herpeto_peptide PF14409.1 AMD21974.1 - 0.064 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Herpetosiphon DUF1663 PF07909.6 AMD21974.1 - 0.1 11.0 0.0 0.14 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1663) eIF-3c_N PF05470.7 AMD21975.1 - 1.7e-151 505.2 17.3 1.5e-118 396.5 2.3 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 AMD21975.1 - 6.5e-11 42.4 0.8 3.1e-09 37.1 0.1 3.9 4 1 0 4 4 4 1 PCI domain HMG_box PF00505.14 AMD21976.1 - 0.0042 17.3 2.5 2.7 8.3 0.1 3.4 3 0 0 3 3 3 2 HMG (high mobility group) box DUF4407 PF14362.1 AMD21976.1 - 0.97 8.3 34.7 2 7.2 24.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM60A PF15396.1 AMD21976.1 - 1.6 8.4 19.0 7.4 6.2 12.6 2.5 2 0 0 2 2 2 0 Protein Family FAM60A Mem_trans PF03547.13 AMD21976.1 - 3.6 5.7 7.4 0.19 10.0 1.6 1.6 2 0 0 2 2 2 0 Membrane transport protein LMBR1 PF04791.11 AMD21976.1 - 6.6 5.1 7.0 9.8 4.6 4.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein HSP70 PF00012.15 AMD21976.1 - 9.3 4.0 20.5 16 3.2 14.2 1.3 1 0 0 1 1 1 0 Hsp70 protein eIF3_subunit PF08597.5 AMD21976.1 - 9.3 5.7 27.2 0.036 13.6 11.5 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit ABC_membrane PF00664.18 AMD21977.1 - 1.9e-60 204.6 33.9 2.9e-33 115.4 8.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 AMD21977.1 - 2.6e-48 163.8 0.0 5.9e-29 101.1 0.0 3.1 2 1 0 2 2 2 2 ABC transporter AAA_23 PF13476.1 AMD21977.1 - 5.2e-10 39.9 0.3 3.6e-05 24.1 0.1 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 AMD21977.1 - 1.7e-08 34.0 6.5 0.077 12.2 0.3 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 AMD21977.1 - 5e-08 32.3 0.6 0.0022 17.4 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 AMD21977.1 - 8.7e-08 32.4 2.7 0.0048 16.9 0.0 5.0 3 2 1 4 4 4 1 AAA domain AAA_16 PF13191.1 AMD21977.1 - 5.7e-06 26.4 0.2 0.07 13.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.7 AMD21977.1 - 7.6e-06 25.1 0.1 0.0047 16.0 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin Miro PF08477.8 AMD21977.1 - 9.9e-06 26.0 1.1 0.23 11.9 0.2 3.1 2 0 0 2 2 2 2 Miro-like protein AAA_17 PF13207.1 AMD21977.1 - 0.00011 23.0 0.3 1.1 10.1 0.0 3.3 3 0 0 3 3 2 2 AAA domain DUF258 PF03193.11 AMD21977.1 - 0.00027 20.1 1.6 0.071 12.3 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 AMD21977.1 - 0.00039 20.3 2.7 0.16 11.9 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.1 AMD21977.1 - 0.00085 19.6 3.3 2.1 8.6 0.0 3.7 4 0 0 4 4 3 2 AAA domain Dynamin_N PF00350.18 AMD21977.1 - 0.0014 18.4 0.1 0.72 9.6 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_15 PF13175.1 AMD21977.1 - 0.0022 17.1 0.4 0.17 10.9 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain FtsK_SpoIIIE PF01580.13 AMD21977.1 - 0.0023 17.4 0.1 1.2 8.5 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_25 PF13481.1 AMD21977.1 - 0.0073 15.7 0.1 0.47 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 AMD21977.1 - 0.024 14.2 1.8 0.058 13.0 0.3 2.1 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 AMD21977.1 - 0.029 13.9 1.2 3 7.3 0.1 2.8 3 0 0 3 3 3 0 AAA domain T2SE PF00437.15 AMD21977.1 - 0.06 12.2 1.8 1.3 7.8 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ATP-synt_ab PF00006.20 AMD21977.1 - 0.18 11.2 0.0 4.6 6.6 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.4 AMD21977.1 - 0.21 11.0 0.7 2.8 7.4 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 AMD21977.1 - 0.28 11.3 5.1 8.5 6.5 0.3 3.6 3 1 0 3 3 3 0 AAA domain AAA_28 PF13521.1 AMD21977.1 - 0.33 10.8 1.2 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 AMD21977.1 - 0.85 9.0 4.0 0.94 8.9 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Fungal_trans PF04082.13 AMD21978.1 - 3.2e-20 72.0 0.1 7.2e-20 70.9 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain HEAT_2 PF13646.1 AMD21979.1 - 1.3e-20 73.4 0.0 4.2e-08 33.3 0.0 6.3 4 2 2 6 6 6 4 HEAT repeats HEAT_EZ PF13513.1 AMD21979.1 - 5.8e-20 71.1 7.8 5.4e-07 29.9 0.0 10.8 10 2 3 13 13 13 3 HEAT-like repeat HEAT PF02985.17 AMD21979.1 - 5.2e-19 66.5 11.2 0.0078 16.2 0.0 9.9 11 0 0 11 11 11 4 HEAT repeat Arm PF00514.18 AMD21979.1 - 5.5e-07 29.1 0.4 5.8 6.8 0.0 5.9 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat MMS19_C PF12460.3 AMD21979.1 - 7.7e-07 28.1 13.1 0.0048 15.6 3.3 4.4 3 1 1 5 5 5 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.2 AMD21979.1 - 8.6e-06 26.0 0.1 0.34 11.3 0.0 5.7 3 2 4 7 7 7 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 AMD21979.1 - 1.1e-05 24.9 0.2 0.035 13.4 0.6 5.0 4 2 1 5 5 5 1 CLASP N terminal ParcG PF10274.4 AMD21979.1 - 0.0013 18.6 3.2 0.11 12.4 0.0 3.5 4 0 0 4 4 4 1 Parkin co-regulated protein DNA_alkylation PF08713.6 AMD21979.1 - 0.0032 16.9 0.0 0.013 15.0 0.0 2.0 1 1 0 1 1 1 1 DNA alkylation repair enzyme DUF3385 PF11865.3 AMD21979.1 - 0.0033 17.3 0.1 0.18 11.6 0.1 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3385) G-patch PF01585.18 AMD21980.1 - 1e-09 38.0 0.5 2.1e-09 36.9 0.3 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 AMD21980.1 - 0.00051 19.8 0.3 0.00051 19.8 0.2 3.2 2 1 0 2 2 1 1 DExH-box splicing factor binding site PLRV_ORF5 PF01690.12 AMD21980.1 - 0.042 13.0 11.6 0.048 12.8 8.0 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein APC_CDC26 PF10471.4 AMD21980.1 - 0.072 13.8 0.8 0.072 13.8 0.6 2.9 1 1 1 2 2 2 0 Anaphase-promoting complex APC subunit 1 MIP-T3 PF10243.4 AMD21980.1 - 0.15 10.5 30.0 0.19 10.1 20.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RR_TM4-6 PF06459.7 AMD21980.1 - 0.44 10.3 16.5 0.67 9.8 11.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.5 AMD21980.1 - 0.53 10.2 26.4 0.96 9.4 18.3 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1510 PF07423.6 AMD21980.1 - 0.57 9.5 27.6 0.72 9.1 17.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Zip PF02535.17 AMD21980.1 - 0.81 8.6 4.8 1 8.3 3.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NARP1 PF12569.3 AMD21980.1 - 0.98 8.0 20.7 1.2 7.7 14.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Neur_chan_memb PF02932.11 AMD21980.1 - 1.1 9.1 5.8 1.4 8.7 4.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Parvo_coat PF00740.13 AMD21980.1 - 1.2 7.9 6.9 1.5 7.6 4.8 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Serinc PF03348.10 AMD21980.1 - 2.1 6.9 4.4 2.8 6.5 3.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4407 PF14362.1 AMD21980.1 - 2.6 6.9 8.8 3 6.7 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.2 AMD21980.1 - 2.8 5.4 13.4 3.2 5.3 9.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Paramyxo_ncap PF00973.14 AMD21980.1 - 3.2 6.3 10.1 4 6.0 7.0 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FAM60A PF15396.1 AMD21980.1 - 4.3 7.0 17.6 7.1 6.3 12.2 1.4 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.9 AMD21980.1 - 5 5.0 18.4 6.2 4.7 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_72 PF03198.9 AMD21981.1 - 2.6e-144 480.0 3.2 3.5e-144 479.5 2.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 AMD21981.1 - 5.7e-25 87.6 4.1 1.6e-24 86.1 2.8 1.8 1 0 0 1 1 1 1 X8 domain Glyco_hydro_72 PF03198.9 AMD21982.1 - 3.7e-134 446.6 3.5 5.4e-134 446.1 2.4 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 AMD21982.1 - 5.5e-26 90.8 5.3 1.5e-25 89.4 3.7 1.8 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.13 AMD21982.1 - 0.00024 20.3 0.3 0.006 15.8 0.2 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glucan_synthase PF02364.10 AMD21983.1 - 0 1345.7 0.1 0 1345.7 0.1 2.0 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 AMD21983.1 - 1.3e-37 128.3 0.7 2.6e-37 127.3 0.0 2.0 2 0 0 2 2 2 1 1,3-beta-glucan synthase subunit FKS1, domain-1 NOG1 PF06858.9 AMD21983.1 - 0.21 11.4 7.2 1.6 8.6 0.1 3.5 3 0 0 3 3 3 0 Nucleolar GTP-binding protein 1 (NOG1) Glyco_hydro_17 PF00332.13 AMD21984.1 - 6.4e-07 28.7 0.6 1.4e-06 27.6 0.4 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 PhageMin_Tail PF10145.4 AMD21984.1 - 0.009 15.6 0.2 1.6 8.3 0.1 2.3 2 0 0 2 2 2 2 Phage-related minor tail protein DUF605 PF04652.11 AMD21984.1 - 9.4 5.5 19.8 14 4.9 13.7 1.2 1 0 0 1 1 1 0 Vta1 like MA3 PF02847.12 AMD21985.1 - 2.5e-19 69.0 0.3 8.8e-19 67.2 0.0 2.1 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.14 AMD21985.1 - 8.8e-06 25.2 3.6 8.8e-06 25.2 2.5 1.9 2 0 0 2 2 2 1 MIF4G domain CTP_transf_2 PF01467.21 AMD21986.1 - 3e-11 43.5 0.0 4.9e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase AAA_6 PF12774.2 AMD21986.1 - 0.062 12.8 0.0 0.095 12.2 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region D1 USP7_C2 PF14533.1 AMD21987.1 - 8e-55 185.5 3.2 8e-55 185.5 2.2 3.3 3 1 1 4 4 4 1 Ubiquitin-specific protease C-terminal UCH PF00443.24 AMD21987.1 - 2.4e-53 180.9 2.1 2.4e-53 180.9 1.5 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.3 AMD21987.1 - 7.6e-32 110.5 0.5 3e-31 108.5 0.1 2.1 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.1 AMD21987.1 - 1.4e-31 110.1 0.0 3e-31 108.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UN_NPL4 PF11543.3 AMD21987.1 - 0.049 13.9 0.4 0.88 9.9 0.0 3.2 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 RNA12 PF10443.4 AMD21988.1 - 8.3e-165 548.4 0.0 1.1e-164 547.9 0.0 1.2 1 0 0 1 1 1 1 RNA12 protein RRM_1 PF00076.17 AMD21988.1 - 2.4e-06 27.1 0.0 7.3e-06 25.5 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arch_ATPase PF01637.13 AMD21988.1 - 3.3e-06 26.9 0.5 2.3e-05 24.2 0.0 2.5 2 1 0 2 2 2 1 Archaeal ATPase AAA_14 PF13173.1 AMD21988.1 - 0.00013 21.9 0.1 0.0014 18.5 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 AMD21988.1 - 0.0064 16.6 0.0 0.074 13.2 0.0 2.6 1 1 0 1 1 1 1 AAA domain ADH_zinc_N PF00107.21 AMD21989.1 - 2.1e-20 72.6 0.3 3.4e-20 71.9 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 AMD21989.1 - 7.5e-05 23.6 0.0 0.00019 22.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.3 AMD21989.1 - 0.018 14.2 0.1 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) Transp_cyt_pur PF02133.10 AMD21990.1 - 5.8e-71 239.3 34.6 9.2e-71 238.6 24.0 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin FH2 PF02181.18 AMD21991.1 - 9.1e-63 212.3 8.7 9.1e-63 212.3 6.0 2.5 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.8 AMD21991.1 - 6.7e-09 35.3 2.0 6.7e-09 35.3 1.4 3.6 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain CheB_methylest PF01339.12 AMD21991.1 - 0.013 14.8 0.0 0.033 13.6 0.0 1.6 1 0 0 1 1 1 0 CheB methylesterase Syntaxin-6_N PF09177.6 AMD21991.1 - 0.15 12.4 8.2 0.22 11.9 3.5 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Pyrid_oxidase_2 PF13883.1 AMD21992.1 - 7.5e-15 55.0 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Aldo_ket_red PF00248.16 AMD21993.1 - 1.5e-53 181.4 0.0 1.8e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Asp PF00026.18 AMD21994.1 - 3.2e-66 223.7 0.0 3.8e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD21994.1 - 3.4e-07 30.3 0.0 5.4e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 AMD21994.1 - 0.015 14.8 0.0 1.8 8.1 0.0 2.3 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Lys PF00062.15 AMD21995.1 - 0.0096 15.9 0.2 0.015 15.2 0.1 1.3 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family NiFeSe_Hases PF00374.14 AMD21995.1 - 0.018 13.8 0.3 0.023 13.4 0.2 1.0 1 0 0 1 1 1 0 Nickel-dependent hydrogenase Aminotran_4 PF01063.14 AMD21996.1 - 4.2e-28 98.3 0.0 5.9e-28 97.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV 5-FTHF_cyc-lig PF01812.15 AMD21997.1 - 2.8e-39 134.8 0.0 3.2e-39 134.6 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family SET PF00856.23 AMD21999.1 - 2.4e-12 47.4 0.0 5.2e-11 43.1 0.0 2.5 1 1 0 1 1 1 1 SET domain GAGA PF09237.6 AMD21999.1 - 0.079 12.5 0.0 0.2 11.2 0.0 1.7 1 0 0 1 1 1 0 GAGA factor HSF_DNA-bind PF00447.12 AMD22000.1 - 3.7e-36 123.4 4.4 9.1e-36 122.1 2.9 1.8 2 0 0 2 2 2 1 HSF-type DNA-binding Response_reg PF00072.19 AMD22000.1 - 6.2e-27 93.8 0.2 1.4e-26 92.7 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HALZ PF02183.13 AMD22000.1 - 0.0024 17.5 0.2 0.0045 16.6 0.2 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF904 PF06005.7 AMD22000.1 - 0.017 15.4 0.0 0.043 14.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF4559 PF15112.1 AMD22000.1 - 0.054 12.6 0.2 0.11 11.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) bZIP_1 PF00170.16 AMD22000.1 - 0.09 12.7 0.2 0.23 11.4 0.1 1.7 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.10 AMD22000.1 - 0.11 12.0 0.2 0.25 10.8 0.2 1.5 1 0 0 1 1 1 0 Septum formation initiator Methyltransf_26 PF13659.1 AMD22000.1 - 0.13 12.2 0.0 0.49 10.4 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.20 AMD22001.1 - 5.5e-69 232.1 0.0 7.5e-69 231.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22001.1 - 5e-31 107.7 0.0 7.3e-31 107.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 AMD22001.1 - 5.1e-13 49.3 3.0 1.5e-12 47.8 2.1 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 AMD22001.1 - 6.8e-09 35.0 0.0 1.7e-08 33.7 0.0 1.7 1 1 1 2 2 2 1 Kinase-like C2 PF00168.25 AMD22001.1 - 6.6e-05 22.6 0.0 0.00035 20.3 0.0 2.2 1 1 0 1 1 1 1 C2 domain YrbL-PhoP_reg PF10707.4 AMD22001.1 - 0.073 12.3 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 AMD22001.1 - 0.14 11.8 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Glyco_hydro_47 PF01532.15 AMD22002.1 - 7.6e-124 413.8 0.9 9.2e-124 413.5 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ribosomal_S4e PF00900.15 AMD22003.1 - 3.8e-34 116.1 1.4 1e-33 114.7 0.7 1.8 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.7 AMD22003.1 - 6.6e-20 70.6 4.4 1.4e-19 69.6 3.1 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 AMD22003.1 - 1.8e-07 30.4 0.1 4.8e-07 29.1 0.0 1.8 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 AMD22003.1 - 2.9e-05 23.6 1.2 2.9e-05 23.6 0.8 3.5 4 0 0 4 4 4 1 KOW motif Metallophos PF00149.23 AMD22004.1 - 2.8e-09 36.6 4.3 6.5e-09 35.4 3.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Ligase_CoA PF00549.14 AMD22005.1 - 1.8e-24 86.0 0.6 3.3e-24 85.2 0.4 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.14 AMD22005.1 - 1.1e-23 83.5 3.4 5e-23 81.4 0.6 2.3 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.1 AMD22005.1 - 2.5e-08 33.6 0.1 4.3e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 AMD22005.1 - 1.1e-05 25.5 0.1 5.5e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 CoA binding domain Actin PF00022.14 AMD22006.1 - 8.9e-24 83.6 0.0 5.3e-16 58.0 0.0 3.3 3 1 0 3 3 3 3 Actin MreB_Mbl PF06723.8 AMD22006.1 - 6e-06 25.0 0.0 0.00074 18.2 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein DUF507 PF04368.8 AMD22006.1 - 0.028 14.0 4.8 2 8.0 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF507) FtsA PF14450.1 AMD22006.1 - 2.3 8.0 5.4 0.7 9.7 0.1 2.5 2 1 0 2 2 2 0 Cell division protein FtsA HSF_DNA-bind PF00447.12 AMD22007.1 - 8.8e-38 128.6 0.3 2.6e-37 127.1 0.2 1.8 1 0 0 1 1 1 1 HSF-type DNA-binding DUF3436 PF11918.3 AMD22007.1 - 1.4 9.2 4.6 16 5.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3436) Iso_dh PF00180.15 AMD22008.1 - 1.1e-99 333.6 0.1 1.3e-99 333.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ThiF PF00899.16 AMD22009.1 - 6.3e-34 116.7 0.0 1.5e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 AMD22009.1 - 2.1e-24 84.8 1.0 4.3e-24 83.8 0.6 1.7 1 1 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 AMD22009.1 - 1.3e-20 72.5 3.5 2.2e-20 71.7 2.5 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.1 AMD22009.1 - 0.0082 16.2 0.4 0.0082 16.2 0.3 2.6 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.15 AMD22009.1 - 0.027 14.5 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Utp13 PF08625.6 AMD22009.1 - 0.041 13.5 0.4 0.1 12.2 0.2 1.7 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain NAD_binding_7 PF13241.1 AMD22009.1 - 0.095 12.9 0.0 0.32 11.2 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding RhoGAP PF00620.22 AMD22010.1 - 1.5e-31 109.0 0.0 5.5e-18 65.0 0.0 2.5 2 0 0 2 2 2 2 RhoGAP domain BAR PF03114.13 AMD22011.1 - 2.5e-52 177.6 9.4 3.1e-52 177.3 6.5 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.1 AMD22011.1 - 4.3e-13 48.6 0.1 7.8e-13 47.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 AMD22011.1 - 1.4e-11 43.5 1.3 1.8e-11 43.2 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 AMD22011.1 - 4.5e-06 26.0 0.0 8.9e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF869 PF05911.6 AMD22011.1 - 2.3 6.3 12.2 0.39 8.8 6.0 1.4 2 0 0 2 2 2 0 Plant protein of unknown function (DUF869) ERCC4 PF02732.10 AMD22012.1 - 1.5e-22 79.8 0.1 4.1e-22 78.4 0.0 1.8 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 AMD22012.1 - 0.0016 18.6 0.0 0.0034 17.5 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain GTP_EFTU PF00009.22 AMD22013.1 - 5.6e-63 211.7 0.2 7.9e-63 211.2 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 AMD22013.1 - 1.2e-37 128.1 0.0 3e-37 126.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 AMD22013.1 - 2.3e-21 75.4 0.0 6.3e-21 74.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 AMD22013.1 - 7e-14 51.7 0.7 4.2e-13 49.2 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 EFG_II PF14492.1 AMD22013.1 - 3e-13 49.4 0.0 1.1e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 AMD22013.1 - 6.2e-06 26.1 0.2 1.3e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SUKH-4 PF14435.1 AMD22013.1 - 0.097 12.3 0.1 0.38 10.4 0.0 2.0 2 0 0 2 2 2 0 SUKH-4 immunity protein PduV-EutP PF10662.4 AMD22013.1 - 0.12 11.8 0.4 0.56 9.6 0.2 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PX PF00787.19 AMD22014.1 - 8.1e-10 38.4 2.2 1.1e-09 38.0 0.1 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 AMD22014.1 - 1.1e-07 31.3 9.2 1.6e-07 30.8 6.4 1.2 1 0 0 1 1 1 1 Vps5 C terminal like IZUMO PF15005.1 AMD22014.1 - 1.2 9.1 5.1 0.39 10.7 0.2 2.5 3 0 0 3 3 3 0 Izumo sperm-egg fusion MFS_1 PF07690.11 AMD22015.1 - 1.6e-23 83.0 34.2 1.6e-23 83.0 23.7 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 AMD22015.1 - 4.9e-21 74.8 29.5 1.2e-20 73.5 20.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_3 PF05977.8 AMD22015.1 - 0.004 15.3 0.1 0.004 15.3 0.1 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector Ribosomal_L4 PF00573.17 AMD22016.1 - 9.4e-45 152.3 1.7 1.5e-44 151.6 1.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 AMD22016.1 - 1e-29 102.1 5.7 3.3e-29 100.5 1.4 2.7 2 1 1 3 3 3 1 60S ribosomal protein L4 C-terminal domain Methyltransf_31 PF13847.1 AMD22017.1 - 1.4e-13 50.6 0.0 3.2e-13 49.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD22017.1 - 5.4e-12 46.2 0.0 1.5e-10 41.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 AMD22017.1 - 3.9e-11 42.6 0.0 6e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 AMD22017.1 - 6e-11 42.4 0.0 1.7e-10 40.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 AMD22017.1 - 6.2e-08 33.0 0.0 2.6e-07 31.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 AMD22017.1 - 2.8e-07 29.8 0.0 4e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 AMD22017.1 - 3.1e-07 30.2 0.0 5.9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AMD22017.1 - 1.3e-06 27.8 0.0 2.3e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 AMD22017.1 - 5.1e-06 26.7 0.0 2.9e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.6 AMD22017.1 - 5.2e-06 25.3 0.0 7.1e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PRMT5 PF05185.11 AMD22017.1 - 4.7e-05 22.4 0.0 5.7e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.7 AMD22017.1 - 0.00025 21.4 0.0 0.00083 19.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 AMD22017.1 - 0.00041 20.3 0.0 0.0014 18.6 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.4 AMD22017.1 - 0.00042 19.8 0.0 0.00064 19.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.14 AMD22017.1 - 0.0011 18.5 0.1 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 AMD22017.1 - 0.0012 18.0 0.1 0.0027 16.8 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family UPF0020 PF01170.13 AMD22017.1 - 0.0084 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.11 AMD22017.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_32 PF13679.1 AMD22017.1 - 0.027 14.1 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 AMD22017.1 - 0.029 15.2 0.0 0.056 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 AMD22017.1 - 0.055 12.5 0.0 0.086 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase TehB PF03848.9 AMD22017.1 - 0.062 12.4 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB Cons_hypoth95 PF03602.10 AMD22017.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Sld5 PF05916.6 AMD22018.1 - 1.3e-12 47.9 0.3 1.9e-12 47.4 0.2 1.3 1 0 0 1 1 1 1 GINS complex protein PIF1 PF05970.9 AMD22018.1 - 0.0067 15.4 0.0 0.016 14.2 0.0 1.5 1 1 1 2 2 2 1 PIF1-like helicase TRF PF08558.5 AMD22018.1 - 0.017 14.4 0.2 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) PNPOx_C PF10590.4 AMD22020.1 - 3.7e-18 64.7 1.9 7.7e-18 63.7 1.3 1.6 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxidase PF01243.15 AMD22020.1 - 1.8e-14 53.5 0.0 3.5e-14 52.5 0.0 1.5 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.2 AMD22020.1 - 7.2e-05 23.0 0.1 0.00013 22.1 0.1 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF1776 PF08643.5 AMD22020.1 - 0.042 12.9 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DASH_Dad1 PF08649.5 AMD22021.1 - 9.9e-29 98.8 3.5 1.7e-28 98.0 1.3 1.9 2 0 0 2 2 2 1 DASH complex subunit Dad1 IPK PF03770.11 AMD22022.1 - 2.6e-49 167.5 0.2 2.6e-49 167.5 0.2 1.8 2 0 0 2 2 2 1 Inositol polyphosphate kinase ATP-synt PF00231.14 AMD22023.1 - 1.1e-67 228.4 6.7 1.2e-67 228.2 4.6 1.0 1 0 0 1 1 1 1 ATP synthase Folliculin PF11704.3 AMD22023.1 - 0.046 13.3 3.1 0.16 11.5 0.5 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Cache_3 PF14827.1 AMD22023.1 - 0.079 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Sensory domain of two-component sensor kinase Fig1 PF12351.3 AMD22024.1 - 1.7e-39 135.5 4.8 1.7e-39 135.5 3.4 1.7 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.7 AMD22024.1 - 0.0031 17.0 12.1 0.0053 16.3 8.4 1.4 1 1 0 1 1 1 1 SUR7/PalI family MFS_1 PF07690.11 AMD22024.1 - 0.75 8.4 11.0 9.2 4.8 6.7 2.6 2 1 1 3 3 3 0 Major Facilitator Superfamily AMP-binding PF00501.23 AMD22025.1 - 3.5e-65 220.0 0.0 4.1e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 AMD22025.1 - 9.1e-06 26.5 0.0 2.3e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acyltransferase PF01553.16 AMD22026.1 - 1.2e-26 92.6 0.0 2e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase MFS_1 PF07690.11 AMD22027.1 - 2.3e-38 131.8 34.7 2.3e-38 131.8 24.0 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Wbp11 PF09429.5 AMD22027.1 - 0.16 11.9 0.7 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 WW domain binding protein 11 Dynactin_p62 PF05502.8 AMD22027.1 - 0.18 10.5 0.6 0.25 10.0 0.4 1.1 1 0 0 1 1 1 0 Dynactin p62 family YCII PF03795.9 AMD22030.1 - 2.9e-08 33.7 0.0 3.6e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Profilin PF00235.14 AMD22031.1 - 1.8e-38 131.3 0.1 2e-38 131.2 0.1 1.0 1 0 0 1 1 1 1 Profilin MEDS PF14417.1 AMD22031.1 - 0.086 11.8 0.0 0.094 11.7 0.0 1.1 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Leo1 PF04004.8 AMD22032.1 - 7.7e-43 146.1 0.3 1.5e-42 145.1 0.2 1.5 1 0 0 1 1 1 1 Leo1-like protein HUN PF08729.5 AMD22032.1 - 0.0036 17.1 5.6 0.015 15.1 3.9 2.1 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Glyco_hydro_18 PF00704.23 AMD22033.1 - 3.9e-76 256.7 2.4 4.7e-76 256.4 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.6 AMD22034.1 - 2.2e-63 214.0 0.0 2.8e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) UCH PF00443.24 AMD22035.1 - 2.1e-57 194.3 7.0 6.9e-57 192.5 4.8 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 AMD22035.1 - 1.9e-41 139.2 6.9 7.7e-16 57.2 0.1 5.2 5 0 0 5 5 5 4 A repeated domain in UCH-protein UCH_1 PF13423.1 AMD22035.1 - 1.6e-09 37.6 10.2 7.2e-05 22.3 0.1 3.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase EF-hand_1 PF00036.27 AMD22036.1 - 4.1e-28 94.5 7.6 1e-07 30.6 0.3 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 AMD22036.1 - 8.9e-25 84.3 2.9 2.1e-06 27.1 0.1 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 AMD22036.1 - 1.4e-24 85.9 4.2 1.5e-14 53.8 0.2 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 AMD22036.1 - 3.2e-18 64.1 8.7 3.2e-06 26.2 0.2 5.3 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 AMD22036.1 - 1.6e-17 62.8 8.2 9.7e-10 37.9 0.1 3.8 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 AMD22036.1 - 7.6e-06 25.9 1.4 0.2 11.7 0.1 2.9 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 AMD22036.1 - 3e-05 23.6 5.8 0.45 10.2 0.1 3.6 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 AMD22036.1 - 0.0022 17.8 0.3 0.33 10.8 0.0 3.0 1 1 1 2 2 2 1 EF-hand domain S10_plectin PF03501.10 AMD22036.1 - 0.0065 16.2 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Plectin/S10 domain EF-hand_10 PF14788.1 AMD22036.1 - 0.05 13.2 1.3 6.9 6.4 0.1 3.3 3 0 0 3 3 3 0 EF hand COQ7 PF03232.8 AMD22037.1 - 7.2e-74 246.9 0.1 1.1e-73 246.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 PARP_regulatory PF01358.13 AMD22037.1 - 0.052 12.1 0.3 0.069 11.7 0.2 1.2 1 0 0 1 1 1 0 Poly A polymerase regulatory subunit Rubrerythrin PF02915.12 AMD22037.1 - 0.093 13.0 0.8 0.15 12.3 0.0 1.8 3 0 0 3 3 3 0 Rubrerythrin YTH PF04146.10 AMD22038.1 - 2.7e-38 130.7 0.1 4.7e-38 129.9 0.1 1.4 1 0 0 1 1 1 1 YT521-B-like domain Sel1 PF08238.7 AMD22039.1 - 4.8e-21 74.6 19.6 0.00037 21.0 0.1 8.5 9 0 0 9 9 9 6 Sel1 repeat TPR_12 PF13424.1 AMD22039.1 - 0.0046 16.8 10.8 0.038 13.9 0.2 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 AMD22039.1 - 0.008 15.8 4.8 1.7 8.6 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD22039.1 - 0.016 14.9 16.0 0.99 9.3 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 AMD22039.1 - 0.12 12.3 12.9 0.23 11.4 0.2 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.1 AMD22039.1 - 0.21 11.2 9.8 4.1 7.1 0.1 4.6 3 2 2 5 5 5 0 TPR repeat TPR_1 PF00515.23 AMD22039.1 - 3.7 7.2 16.3 1.4 8.6 0.2 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Dynactin_p62 PF05502.8 AMD22040.1 - 4.8e-16 58.5 26.9 2.2e-08 33.3 0.1 2.1 2 0 0 2 2 2 2 Dynactin p62 family CENP-X PF09415.5 AMD22041.1 - 4.7e-24 83.9 0.1 5.3e-24 83.8 0.1 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X ENTH PF01417.15 AMD22042.1 - 9.3e-42 141.8 0.0 1.9e-41 140.7 0.0 1.6 1 0 0 1 1 1 1 ENTH domain DNA_ligase_A_M PF01068.16 AMD22043.1 - 2.8e-59 199.9 0.1 4.1e-59 199.3 0.1 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 AMD22043.1 - 1.4e-51 174.8 0.0 2.1e-51 174.2 0.0 1.3 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 AMD22043.1 - 2.7e-23 82.1 0.0 1.1e-22 80.2 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 AMD22043.1 - 0.11 12.2 0.1 1.9 8.1 0.0 2.4 2 0 0 2 2 2 0 DNA ligase OB-like domain DUF1713 PF08213.6 AMD22044.1 - 9.2e-13 47.5 19.6 1.3e-12 47.0 13.6 1.2 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) zf-Mss51 PF13824.1 AMD22045.1 - 4.1e-20 71.3 0.8 4.1e-20 71.3 0.6 2.2 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 NOT2_3_5 PF04153.13 AMD22046.1 - 2.7e-35 121.1 0.2 3.4e-35 120.8 0.1 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family AAA_18 PF13238.1 AMD22047.1 - 1.2e-29 103.2 0.4 1.2e-29 103.2 0.3 1.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD22047.1 - 3e-16 60.3 3.0 1.5e-15 58.0 2.1 1.9 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.1 AMD22047.1 - 3.8e-05 23.6 0.3 0.00012 21.9 0.2 2.0 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_28 PF13521.1 AMD22047.1 - 3.9e-05 23.6 0.0 0.0001 22.2 0.0 1.7 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 AMD22047.1 - 0.0001 22.5 0.0 0.00021 21.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 AMD22047.1 - 0.00011 22.1 0.1 0.043 13.6 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AMD22047.1 - 0.00013 21.8 0.2 0.0004 20.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.12 AMD22047.1 - 0.00017 21.0 0.1 0.17 11.2 0.0 2.4 2 1 0 2 2 2 2 Thymidylate kinase GvpD PF07088.6 AMD22047.1 - 0.00023 19.6 0.0 0.00037 18.9 0.0 1.3 1 1 0 1 1 1 1 GvpD gas vesicle protein RNA_helicase PF00910.17 AMD22047.1 - 0.00024 21.2 0.1 0.0005 20.2 0.1 1.5 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.1 AMD22047.1 - 0.00045 20.3 0.0 0.002 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 AMD22047.1 - 0.00076 18.7 0.0 0.0093 15.1 0.0 2.1 2 0 0 2 2 2 1 Chromatin associated protein KTI12 NTPase_1 PF03266.10 AMD22047.1 - 0.0031 17.2 0.0 0.0066 16.1 0.0 1.5 1 0 0 1 1 1 1 NTPase ADK PF00406.17 AMD22047.1 - 0.0044 16.9 0.0 0.61 9.9 0.0 2.3 2 0 0 2 2 2 1 Adenylate kinase AAA_5 PF07728.9 AMD22047.1 - 0.0058 16.3 0.0 0.0098 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) SKI PF01202.17 AMD22047.1 - 0.006 16.4 0.5 0.066 13.0 0.3 2.0 1 1 0 1 1 1 1 Shikimate kinase Viral_helicase1 PF01443.13 AMD22047.1 - 0.0061 16.1 0.0 0.0087 15.5 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.4 AMD22047.1 - 0.0075 15.7 0.1 0.047 13.1 0.0 2.0 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.7 AMD22047.1 - 0.0078 15.3 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin ABC_tran PF00005.22 AMD22047.1 - 0.012 15.8 0.0 0.058 13.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.1 AMD22047.1 - 0.014 15.4 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.1 AMD22047.1 - 0.016 14.9 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain Rad17 PF03215.10 AMD22047.1 - 0.019 13.6 0.0 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Mg_chelatase PF01078.16 AMD22047.1 - 0.043 12.9 0.0 0.063 12.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SRPRB PF09439.5 AMD22047.1 - 0.049 12.8 0.0 0.089 11.9 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit T2SE PF00437.15 AMD22047.1 - 0.049 12.5 0.0 0.088 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_10 PF12846.2 AMD22047.1 - 0.078 12.3 0.2 0.099 12.0 0.1 1.7 1 1 0 1 1 1 0 AAA-like domain zf-RanBP PF00641.13 AMD22048.1 - 8.4e-19 66.3 10.7 5.6e-10 38.1 1.2 2.6 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 AMD22048.1 - 3.1e-07 29.9 0.0 0.00085 18.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22048.1 - 0.06 13.3 0.0 0.34 10.9 0.0 2.2 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 AMD22048.1 - 0.11 12.3 10.4 1.6 8.6 1.3 2.5 2 0 0 2 2 2 0 Double zinc ribbon PAT1 PF09770.4 AMD22048.1 - 0.57 8.3 26.8 0.78 7.9 18.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Dicty_REP PF05086.7 AMD22048.1 - 1 7.0 6.5 1.5 6.4 4.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-ribbon_3 PF13248.1 AMD22048.1 - 2.8 7.2 9.2 3.9 6.7 0.2 3.0 3 0 0 3 3 3 0 zinc-ribbon domain ADH_N PF08240.7 AMD22049.1 - 1e-25 89.5 1.6 1e-25 89.5 1.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 AMD22049.1 - 2.4e-19 69.1 0.1 4.1e-19 68.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 AMD22049.1 - 0.021 13.9 0.1 0.036 13.2 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 AMD22049.1 - 0.03 14.3 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Gp_dh_N PF00044.19 AMD22049.1 - 0.057 13.3 0.4 0.6 10.0 0.3 2.2 1 1 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.1 AMD22049.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase COQ9 PF08511.6 AMD22050.1 - 2.1e-19 68.7 0.2 4.6e-19 67.6 0.1 1.5 1 0 0 1 1 1 1 COQ9 Prefoldin_2 PF01920.15 AMD22051.1 - 6.8e-23 80.4 11.5 7.2e-23 80.3 8.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF1192 PF06698.6 AMD22051.1 - 0.02 14.7 0.5 0.02 14.7 0.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) Macoilin PF09726.4 AMD22051.1 - 0.22 9.7 6.4 0.28 9.4 4.5 1.1 1 0 0 1 1 1 0 Transmembrane protein YgaB PF14182.1 AMD22051.1 - 0.28 11.4 8.0 0.18 12.0 0.4 2.2 2 0 0 2 2 2 0 YgaB-like protein OmpH PF03938.9 AMD22051.1 - 0.46 10.4 5.0 0.76 9.6 3.5 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Prefoldin PF02996.12 AMD22051.1 - 0.48 10.0 7.5 1.9 8.1 5.2 1.8 1 1 0 1 1 1 0 Prefoldin subunit DUF1843 PF08898.5 AMD22051.1 - 0.53 10.3 5.9 1.4 8.9 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) DUF1664 PF07889.7 AMD22051.1 - 0.75 9.5 4.3 0.5 10.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FliJ PF02050.11 AMD22051.1 - 0.96 9.5 10.5 3.7 7.6 0.2 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein Spc24 PF08286.6 AMD22051.1 - 1.1 8.9 12.5 1.1 8.9 2.3 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Fib_alpha PF08702.5 AMD22051.1 - 2.3 8.3 6.6 2.1 8.4 0.4 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Seryl_tRNA_N PF02403.17 AMD22051.1 - 3.5 7.6 11.4 5.4 7.0 1.1 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Med9 PF07544.8 AMD22051.1 - 4.7 7.0 7.1 0.58 9.9 0.9 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4164 PF13747.1 AMD22051.1 - 5.2 7.2 8.9 7.3 6.7 1.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) IncA PF04156.9 AMD22051.1 - 9.5 5.7 10.3 20 4.7 7.1 1.4 1 1 0 1 1 1 0 IncA protein POC1 PF10450.4 AMD22052.1 - 9.5e-42 142.6 0.0 1.1e-41 142.4 0.0 1.0 1 0 0 1 1 1 1 POC1 chaperone Nop PF01798.13 AMD22053.1 - 6.3e-60 200.8 0.1 1.5e-59 199.6 0.1 1.7 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 AMD22053.1 - 5.4e-27 93.3 0.1 1.7e-26 91.7 0.1 1.9 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 AMD22053.1 - 1.6e-22 79.4 0.5 1.6e-22 79.4 0.3 3.7 2 1 1 3 3 3 1 NOP5NT (NUC127) domain MIP-T3 PF10243.4 AMD22053.1 - 0.53 8.7 64.2 0.77 8.1 44.5 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CDC27 PF09507.5 AMD22053.1 - 3.4 6.7 54.5 4.6 6.3 37.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AAA_22 PF13401.1 AMD22054.1 - 4e-10 39.9 0.0 1.1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 AMD22054.1 - 2.6e-09 37.3 0.5 3e-08 33.9 0.0 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Cdc6_C PF09079.6 AMD22054.1 - 4.9e-07 29.3 0.1 1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 CDC6, C terminal AAA_16 PF13191.1 AMD22054.1 - 3.4e-06 27.1 0.0 0.00038 20.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 AMD22054.1 - 0.00075 19.2 0.1 0.0018 17.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 AMD22054.1 - 0.013 15.7 0.0 0.044 14.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.4 AMD22054.1 - 0.043 12.7 0.3 0.88 8.4 0.0 2.7 2 1 1 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 AAA_17 PF13207.1 AMD22054.1 - 0.075 13.8 0.1 0.22 12.3 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 AMD22054.1 - 0.086 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Beach PF02138.13 AMD22055.1 - 2.6e-107 358.2 0.0 5.5e-107 357.2 0.0 1.6 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 AMD22055.1 - 2.5e-12 46.5 0.1 6.2e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 AMD22055.1 - 0.045 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily DUF2012 PF09430.5 AMD22056.1 - 0.0098 15.7 0.1 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) Ribosomal_S11 PF00411.14 AMD22057.1 - 1.9e-40 137.4 1.0 2.3e-40 137.1 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF814 PF05670.8 AMD22057.1 - 0.11 12.3 0.0 0.17 11.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF814) Ribosomal_S8 PF00410.14 AMD22058.1 - 8.3e-27 93.5 0.1 1.1e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L39 PF00832.15 AMD22059.1 - 8.3e-22 76.3 11.1 9.8e-22 76.1 7.7 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein YchF-GTPase_C PF06071.8 AMD22060.1 - 7.7e-37 124.9 0.5 1.7e-36 123.8 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 AMD22060.1 - 9e-13 48.2 0.0 1.7e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 AMD22060.1 - 0.00024 20.8 0.0 0.00051 19.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 AMD22060.1 - 0.0084 15.3 0.0 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Dna2 PF08696.6 AMD22060.1 - 0.0085 15.4 0.1 0.019 14.2 0.1 1.6 1 0 0 1 1 1 1 DNA replication factor Dna2 SecA_PP_bind PF01043.15 AMD22060.1 - 0.055 13.8 0.5 0.83 10.0 0.0 2.3 2 0 0 2 2 2 0 SecA preprotein cross-linking domain MobB PF03205.9 AMD22060.1 - 0.079 12.6 0.4 6.2 6.5 0.0 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B BetaGal_dom3 PF13363.1 AMD22060.1 - 0.091 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase, domain 3 Cupin_2 PF07883.6 AMD22060.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 Cupin domain SCO1-SenC PF02630.9 AMD22061.1 - 7.8e-70 233.9 0.0 1e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 AMD22061.1 - 0.0071 16.0 0.0 0.013 15.2 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family DUF4169 PF13770.1 AMD22061.1 - 0.015 15.2 0.4 0.027 14.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) Chitin_synth_1 PF01644.12 AMD22062.1 - 4.6e-70 234.6 0.4 9.7e-70 233.5 0.3 1.6 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 AMD22062.1 - 2.2e-24 84.9 0.0 6.3e-24 83.4 0.0 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 AMD22062.1 - 3.4e-20 71.9 6.8 5.6e-17 61.3 0.1 2.9 2 1 1 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.1 AMD22062.1 - 2.3e-06 27.4 1.8 2.3e-06 27.4 1.3 2.7 3 2 1 4 4 4 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 AMD22062.1 - 4.5e-06 26.6 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF2576 PF10845.3 AMD22062.1 - 0.018 14.1 0.1 0.054 12.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Chitin_synth_2 PF03142.10 AMD22063.1 - 5.4e-278 922.6 0.0 8.3e-278 922.0 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 AMD22063.1 - 1e-17 64.4 0.8 4.7e-17 62.3 0.6 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 AMD22063.1 - 1.3e-14 54.5 0.0 3.9e-12 46.4 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 AMD22063.1 - 9.9e-06 25.3 0.0 0.00087 19.0 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 AMD22063.1 - 6e-05 22.3 0.0 0.00014 21.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cyt-b5 PF00173.23 AMD22063.1 - 0.00025 20.8 0.0 0.00075 19.2 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain RNR_inhib PF08591.5 AMD22064.1 - 5.1e-15 56.1 0.1 7.6e-15 55.6 0.1 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase inhibitor Aminotran_3 PF00202.16 AMD22065.1 - 3.2e-107 358.2 0.0 3.8e-107 358.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 AMD22065.1 - 2.4e-05 23.6 0.0 5.2e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 AMD22065.1 - 0.12 11.4 0.1 0.32 9.9 0.0 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family cNMP_binding PF00027.24 AMD22066.1 - 7e-40 134.7 0.3 5.6e-17 61.3 0.0 4.3 4 0 0 4 4 4 3 Cyclic nucleotide-binding domain Patatin PF01734.17 AMD22066.1 - 1.9e-18 67.1 3.6 4.2e-12 46.4 0.6 3.1 3 0 0 3 3 3 2 Patatin-like phospholipase DPM3 PF08285.6 AMD22066.1 - 0.0012 18.6 3.1 0.0033 17.2 2.1 1.7 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LSM PF01423.17 AMD22067.1 - 6.7e-19 67.2 0.1 7.8e-19 67.0 0.1 1.0 1 0 0 1 1 1 1 LSM domain SH3_9 PF14604.1 AMD22067.1 - 0.065 12.8 0.0 2.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Variant SH3 domain SM-ATX PF14438.1 AMD22067.1 - 0.078 12.9 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain MRP-L47 PF06984.8 AMD22068.1 - 2.1e-24 85.2 2.9 3.2e-24 84.6 0.6 2.2 2 0 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) OGG_N PF07934.7 AMD22069.1 - 3.9e-23 81.6 0.4 1.1e-22 80.1 0.3 1.8 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 AMD22069.1 - 1.2e-15 57.7 0.0 2.3e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein PIF1 PF05970.9 AMD22070.1 - 9.3e-67 225.5 2.1 5.9e-54 183.3 0.4 2.4 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 AMD22070.1 - 2.4e-13 50.1 0.0 4.8e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD22070.1 - 3.6e-06 27.1 0.0 1e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 AMD22070.1 - 7.7e-05 22.7 0.1 0.0033 17.5 0.0 2.7 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 AMD22070.1 - 8.7e-05 20.4 0.4 0.00034 18.5 0.0 1.9 2 0 0 2 2 2 1 Helicase Viral_helicase1 PF01443.13 AMD22070.1 - 0.002 17.6 0.2 0.36 10.3 0.1 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 AMD22070.1 - 0.0052 15.7 0.1 0.021 13.8 0.0 2.0 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 AMD22070.1 - 0.0072 16.5 0.1 0.025 14.7 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 AMD22070.1 - 0.0078 15.1 0.1 0.023 13.5 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.1 AMD22070.1 - 0.017 15.1 0.1 0.048 13.6 0.1 1.8 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.11 AMD22070.1 - 0.037 13.2 0.0 0.1 11.8 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein DEAD PF00270.24 AMD22070.1 - 0.048 13.1 0.1 1.2 8.5 0.0 2.4 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_19 PF13245.1 AMD22070.1 - 0.15 11.8 0.3 0.41 10.4 0.2 1.7 1 0 0 1 1 1 0 Part of AAA domain RNA_helicase PF00910.17 AMD22070.1 - 0.25 11.5 2.4 0.46 10.6 0.1 2.7 2 1 0 2 2 2 0 RNA helicase AAA_17 PF13207.1 AMD22070.1 - 0.84 10.4 4.2 1.3 9.8 0.2 3.1 3 2 0 3 3 3 0 AAA domain Sec39 PF08314.6 AMD22071.1 - 1.2e-111 373.8 18.9 1.5e-111 373.6 13.1 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 THOC7 PF05615.8 AMD22072.1 - 8.7e-12 45.4 7.1 8.7e-12 45.4 4.9 2.1 2 0 0 2 2 2 1 Tho complex subunit 7 Vps53_N PF04100.7 AMD22072.1 - 0.00026 19.8 1.9 0.00026 19.8 1.3 1.8 2 0 0 2 2 2 1 Vps53-like, N-terminal COG2 PF06148.6 AMD22072.1 - 0.049 13.5 6.6 0.15 11.8 1.6 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4546 PF15079.1 AMD22072.1 - 0.076 12.1 5.8 0.44 9.6 0.2 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4546) Reo_sigmaC PF04582.7 AMD22072.1 - 0.25 10.4 1.5 0.45 9.6 0.5 1.7 2 0 0 2 2 2 0 Reovirus sigma C capsid protein CENP-T PF15511.1 AMD22072.1 - 1.2 8.2 16.4 2 7.5 11.4 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Ribosomal_S3Ae PF01015.13 AMD22073.1 - 1.1e-79 266.3 8.4 1.3e-79 266.0 5.8 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.11 AMD22073.1 - 0.024 13.9 0.0 0.083 12.2 0.0 1.9 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Ribosomal_L22 PF00237.14 AMD22073.1 - 0.054 13.4 1.9 1.6 8.6 1.2 2.5 1 1 0 1 1 1 0 Ribosomal protein L22p/L17e Ras PF00071.17 AMD22074.1 - 9.2e-30 103.1 0.0 1.2e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22074.1 - 5.5e-19 68.8 0.0 3e-18 66.4 0.0 2.0 2 1 1 3 3 3 1 Miro-like protein Gtr1_RagA PF04670.7 AMD22074.1 - 4.1e-05 22.8 0.1 5.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 AMD22074.1 - 8.4e-05 21.8 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD22074.1 - 0.00029 20.3 0.1 0.0052 16.2 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD22074.1 - 0.0048 16.8 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 AMD22074.1 - 0.05 12.8 0.0 0.069 12.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.4 AMD22074.1 - 0.075 12.5 0.2 0.4 10.1 0.1 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.24 AMD22075.1 - 1.9e-18 66.9 0.0 4.2e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 AMD22075.1 - 5e-08 33.1 0.0 1.7e-05 24.8 0.0 2.7 1 1 0 1 1 1 1 AAA ATPase domain BAH PF01426.13 AMD22075.1 - 2e-07 30.7 0.6 6.1e-07 29.2 0.1 2.1 2 0 0 2 2 2 1 BAH domain AAA_22 PF13401.1 AMD22075.1 - 2.5e-07 30.8 0.0 1.5e-06 28.3 0.0 2.4 3 0 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 AMD22075.1 - 5.4e-06 26.2 0.1 5.4e-06 26.2 0.0 3.6 3 2 1 4 4 4 2 Archaeal ATPase AAA_17 PF13207.1 AMD22075.1 - 0.0023 18.7 0.6 0.018 15.8 0.0 2.9 3 0 0 3 3 3 1 AAA domain NACHT PF05729.7 AMD22075.1 - 0.003 17.2 0.0 0.0061 16.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.1 AMD22075.1 - 0.0037 17.5 1.6 0.018 15.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 AMD22075.1 - 0.053 13.2 0.1 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain Stm1_N PF09598.5 AMD22075.1 - 3.3 8.4 11.4 1.7 9.3 3.8 3.0 2 0 0 2 2 2 0 Stm1 Cas_Csa4 PF09703.5 AMD22076.1 - 0.00015 20.8 0.1 0.00026 20.1 0.1 1.3 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Csa4) SUR7 PF06687.7 AMD22076.1 - 0.0002 20.9 11.4 0.0011 18.5 7.9 2.1 1 1 0 1 1 1 1 SUR7/PalI family SCIMP PF15050.1 AMD22076.1 - 0.1 12.4 0.2 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 SCIMP protein MLANA PF14991.1 AMD22076.1 - 1.3 9.0 4.3 2.9 7.9 0.4 2.5 2 0 0 2 2 2 0 Protein melan-A GpcrRhopsn4 PF10192.4 AMD22077.1 - 0.0019 17.4 7.8 0.014 14.6 1.5 3.3 2 2 0 3 3 3 2 Rhodopsin-like GPCR transmembrane domain SUR7 PF06687.7 AMD22077.1 - 3.9 6.9 12.5 50 3.3 8.6 2.5 1 1 0 1 1 1 0 SUR7/PalI family COPIIcoated_ERV PF07970.7 AMD22078.1 - 2.6e-30 105.6 0.1 3.9e-30 105.1 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 AMD22078.1 - 6.9e-19 67.6 0.1 6.9e-19 67.6 0.1 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF2660 PF10859.3 AMD22079.1 - 0.021 15.0 0.2 0.038 14.2 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2660) Amdo_NSP PF12475.3 AMD22079.1 - 0.064 13.1 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Amdovirus non-structural protein TipAS PF07739.8 AMD22079.1 - 2.4 8.4 6.9 0.39 11.0 1.7 1.8 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain SSrecog PF03531.9 AMD22080.1 - 8.2e-73 244.4 2.2 5.9e-72 241.5 1.6 2.3 1 1 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 AMD22080.1 - 1.8e-28 98.3 0.3 4.6e-26 90.6 0.1 3.4 4 0 0 4 4 4 1 Histone chaperone Rttp106-like Dak1 PF02733.12 AMD22081.1 - 3.2e-126 420.3 1.0 4.8e-126 419.7 0.7 1.3 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 AMD22081.1 - 9.2e-47 158.9 0.2 1.7e-46 158.1 0.1 1.4 1 0 0 1 1 1 1 DAK2 domain BAR PF03114.13 AMD22082.1 - 1.1e-15 57.7 0.7 3.7e-15 56.0 0.5 1.8 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.1 AMD22082.1 - 5.4e-13 48.3 0.1 1.1e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 AMD22082.1 - 2.7e-12 45.8 0.1 5.5e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 AMD22082.1 - 2.9e-11 42.6 0.0 4.9e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF1804 PF08822.6 AMD22082.1 - 0.0028 17.4 0.1 2.4 7.8 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF1804) DASH_Dad1 PF08649.5 AMD22082.1 - 1.2 8.8 7.7 14 5.4 0.0 3.7 3 1 1 4 4 4 0 DASH complex subunit Dad1 DUF972 PF06156.8 AMD22082.1 - 6.4 7.1 6.4 6.4 7.1 1.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF972) Zn_clus PF00172.13 AMD22083.1 - 2.3e-06 27.3 7.7 4.6e-06 26.4 5.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CoA_binding_2 PF13380.1 AMD22084.1 - 1.5e-19 70.2 0.0 1.9e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain Cyt-b5 PF00173.23 AMD22085.1 - 1.3e-09 37.7 0.0 1.9e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain vATP-synt_AC39 PF01992.11 AMD22086.1 - 2.6e-83 279.9 0.1 3e-83 279.7 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Dor1 PF04124.7 AMD22087.1 - 1.2e-25 89.6 6.4 3e-25 88.4 4.4 1.5 1 1 0 1 1 1 1 Dor1-like family Sec5 PF15469.1 AMD22087.1 - 2.7e-05 23.9 0.4 8e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Exocyst complex component Sec5 TPR_11 PF13414.1 AMD22087.1 - 0.0038 16.8 0.0 0.0092 15.6 0.0 1.6 1 0 0 1 1 1 1 TPR repeat C2 PF00168.25 AMD22088.1 - 2e-40 136.5 1.0 2.4e-17 62.5 0.0 5.4 5 0 0 5 5 5 5 C2 domain Ribosomal_L6e PF01159.14 AMD22089.1 - 2.7e-40 136.9 0.5 3.6e-40 136.5 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e FKBP_C PF00254.23 AMD22090.1 - 1.3e-27 95.6 0.0 1.3e-27 95.6 0.0 2.4 3 1 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase MtrA PF04208.9 AMD22090.1 - 0.15 11.5 3.3 0.34 10.3 2.3 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A ELL PF10390.4 AMD22090.1 - 0.16 11.1 9.1 0.25 10.5 6.3 1.2 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL HMG-CoA_red PF00368.13 AMD22091.1 - 2.4e-156 520.1 0.1 3.6e-156 519.5 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 AMD22091.1 - 1.4e-36 125.4 3.0 1.4e-36 125.4 2.1 1.7 2 0 0 2 2 2 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 AMD22091.1 - 1.5e-07 31.0 8.5 4.7e-07 29.4 5.9 1.9 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Sybindin PF04099.7 AMD22092.1 - 6.5e-21 74.5 0.2 8.3e-21 74.2 0.2 1.1 1 0 0 1 1 1 1 Sybindin-like family ENTH PF01417.15 AMD22093.1 - 1.2e-45 154.3 0.1 2e-45 153.6 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 AMD22093.1 - 0.0004 19.1 0.0 0.00063 18.5 0.0 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.14 AMD22093.1 - 0.001 18.7 0.1 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 VHS domain Pro_isomerase PF00160.16 AMD22094.1 - 8.9e-49 165.6 0.1 1e-48 165.4 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_M28 PF04389.12 AMD22095.1 - 1.7e-12 47.4 0.0 2.8e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.10 AMD22095.1 - 3.7e-11 42.6 0.1 1e-10 41.2 0.0 1.8 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain PA PF02225.17 AMD22095.1 - 0.0012 18.4 0.0 0.0039 16.8 0.0 1.8 2 0 0 2 2 2 1 PA domain Dus PF01207.12 AMD22096.1 - 4.8e-79 265.4 0.0 5.9e-79 265.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DMPK_coil PF08826.5 AMD22097.1 - 0.01 15.7 3.5 0.01 15.7 2.4 2.4 3 0 0 3 3 3 0 DMPK coiled coil domain like Hormone_1 PF00103.15 AMD22097.1 - 0.03 13.6 1.2 0.064 12.5 0.4 1.8 1 1 1 2 2 2 0 Somatotropin hormone family NYD-SP28_assoc PF14775.1 AMD22097.1 - 0.055 13.1 0.4 0.055 13.1 0.3 3.4 3 0 0 3 3 3 0 Sperm tail C-terminal domain DUF1854 PF08909.6 AMD22097.1 - 0.15 11.6 0.3 0.25 10.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1854) DUF837 PF05769.6 AMD22097.1 - 0.23 10.9 6.7 0.47 9.9 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF837) CorA PF01544.13 AMD22097.1 - 0.32 9.9 6.0 5.2 6.0 2.4 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein FTA4 PF13093.1 AMD22097.1 - 0.38 10.1 6.6 4.5 6.6 0.9 2.9 2 1 1 3 3 3 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Med9 PF07544.8 AMD22097.1 - 0.53 10.0 6.3 13 5.6 0.1 3.5 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF972 PF06156.8 AMD22097.1 - 0.59 10.5 6.6 15 5.9 1.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF972) APG6 PF04111.7 AMD22097.1 - 1.1 8.2 11.2 1.2 8.0 6.3 1.7 2 0 0 2 2 2 0 Autophagy protein Apg6 Methyltransf_16 PF10294.4 AMD22098.1 - 5e-20 71.6 0.0 7.6e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 AMD22098.1 - 3.6e-05 24.3 0.0 6.6e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AMD22098.1 - 0.0004 19.8 0.0 0.00067 19.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 AMD22098.1 - 0.00049 19.7 0.0 0.0012 18.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD22098.1 - 0.014 15.8 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain dTMP_synthase PF02593.9 AMD22098.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Thymidylate synthase ATP-synt_J PF04911.7 AMD22099.1 - 3.3e-26 90.5 0.2 3.5e-26 90.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase j chain DUF3054 PF11255.3 AMD22099.1 - 0.11 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) DUF3582 PF12122.3 AMD22099.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3582) Cys_Met_Meta_PP PF01053.15 AMD22100.1 - 5.1e-28 97.4 0.0 1.8e-26 92.3 0.0 2.3 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme PDE6_gamma PF04868.7 AMD22100.1 - 0.063 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit Glyco_hydro_47 PF01532.15 AMD22101.1 - 2.3e-135 451.7 1.9 2.6e-135 451.6 1.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.9 AMD22101.1 - 0.005 16.2 0.8 0.043 13.1 0.0 2.5 2 1 0 2 2 2 1 Glycosyl hydrolase family 76 DUF1563 PF07599.6 AMD22101.1 - 0.36 10.7 7.4 0.075 12.9 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) Ctf8 PF09696.5 AMD22102.1 - 1.8e-21 76.1 0.0 2.5e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 Ctf8 DUF2296 PF10058.4 AMD22103.1 - 1.8e-09 37.1 1.3 3.3e-09 36.3 0.5 1.7 2 0 0 2 2 2 1 Predicted integral membrane metal-binding protein (DUF2296) Orthopox_A5L PF06193.6 AMD22103.1 - 0.001 19.0 1.0 0.15 11.9 0.1 2.4 2 0 0 2 2 2 2 Orthopoxvirus A5L protein-like OmpH PF03938.9 AMD22103.1 - 0.0013 18.7 0.1 0.0024 17.8 0.1 1.5 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) YtpI PF14007.1 AMD22103.1 - 0.031 14.2 0.6 0.058 13.3 0.4 1.4 1 0 0 1 1 1 0 YtpI-like protein CHAD PF05235.9 AMD22103.1 - 0.096 12.2 0.1 0.15 11.6 0.1 1.3 1 1 0 1 1 1 0 CHAD domain Cuticle_3 PF11018.3 AMD22103.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Pupal cuticle protein C1 FliD_N PF02465.13 AMD22103.1 - 0.23 11.8 3.3 0.28 11.5 0.8 2.2 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DASH_Duo1 PF08651.5 AMD22103.1 - 0.29 10.7 4.2 7.2 6.2 0.2 2.6 2 1 0 2 2 2 0 DASH complex subunit Duo1 Prefoldin_2 PF01920.15 AMD22103.1 - 0.54 10.0 7.6 4 7.2 0.0 2.9 2 1 1 3 3 3 0 Prefoldin subunit IncA PF04156.9 AMD22103.1 - 0.98 8.9 11.3 3.8 7.0 6.1 2.5 2 1 0 2 2 2 0 IncA protein SlyX PF04102.7 AMD22103.1 - 1.9 8.9 9.4 15 6.0 1.2 3.3 3 1 1 4 4 4 0 SlyX NAC PF01849.13 AMD22104.1 - 1.1e-19 69.6 0.3 7.7e-19 66.9 0.1 2.1 2 0 0 2 2 2 1 NAC domain UBA PF00627.26 AMD22104.1 - 0.00024 20.8 0.2 0.00047 19.9 0.2 1.4 1 0 0 1 1 1 1 UBA/TS-N domain SPT6_acidic PF14632.1 AMD22104.1 - 0.11 12.6 0.5 0.23 11.6 0.3 1.6 1 1 0 1 1 1 0 Acidic N-terminal SPT6 MDM31_MDM32 PF08118.6 AMD22105.1 - 2.2e-269 894.0 1.1 2.6e-269 893.8 0.7 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins IBN_N PF03810.14 AMD22107.1 - 1.7e-19 69.4 0.0 1.8e-16 59.7 0.0 4.1 3 1 0 3 3 3 2 Importin-beta N-terminal domain DUF212 PF02681.9 AMD22108.1 - 0.04 13.6 0.0 0.084 12.6 0.0 1.5 1 0 0 1 1 1 0 Divergent PAP2 family DUF3479 PF11965.3 AMD22108.1 - 0.1 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) ERG4_ERG24 PF01222.12 AMD22109.1 - 6.1e-155 515.9 14.0 6.9e-155 515.8 9.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 AMD22109.1 - 0.0043 16.3 0.4 0.0043 16.3 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) Aha1_N PF09229.6 AMD22110.1 - 4.5e-30 104.2 1.5 5.5e-30 103.9 1.0 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal S6PP_C PF08472.5 AMD22110.1 - 0.14 11.7 1.5 0.28 10.8 1.1 1.4 1 0 0 1 1 1 0 Sucrose-6-phosphate phosphohydrolase C-terminal RNase_P_pop3 PF08228.6 AMD22111.1 - 7.2e-49 165.6 0.1 8.4e-49 165.4 0.0 1.0 1 0 0 1 1 1 1 RNase P subunit Pop3 WSC PF01822.14 AMD22112.1 - 1.4e-09 37.7 8.7 1.4e-09 37.7 6.0 2.3 2 0 0 2 2 2 1 WSC domain Syndecan PF01034.15 AMD22112.1 - 0.091 12.4 0.1 0.83 9.3 0.0 2.2 2 0 0 2 2 2 0 Syndecan domain SKG6 PF08693.5 AMD22112.1 - 0.16 11.2 1.9 0.87 8.9 1.3 2.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ribosomal_L18e PF00828.14 AMD22113.1 - 2e-22 79.9 1.8 3.1e-22 79.3 0.7 1.7 2 0 0 2 2 2 1 Ribosomal protein L18e/L15 DUF1751 PF08551.5 AMD22114.1 - 2.8e-26 91.7 3.4 2.8e-26 91.7 2.3 2.1 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 AMD22114.1 - 0.22 11.5 10.5 0.054 13.5 4.0 2.1 2 1 0 2 2 2 0 Rhomboid family HLH PF00010.21 AMD22115.1 - 0.00026 20.6 0.1 0.00062 19.4 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PLC-beta_C PF08703.5 AMD22115.1 - 0.00039 20.1 1.1 0.00051 19.8 0.8 1.1 1 0 0 1 1 1 1 PLC-beta C terminal Osmo_CC PF08946.5 AMD22115.1 - 0.012 15.6 0.2 0.032 14.2 0.0 1.8 1 1 0 1 1 1 0 Osmosensory transporter coiled coil YqeY PF09424.5 AMD22115.1 - 0.15 11.8 1.4 0.21 11.4 1.0 1.2 1 0 0 1 1 1 0 Yqey-like protein ADH_zinc_N PF00107.21 AMD22117.1 - 3.5e-07 29.8 0.0 5.9e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AMD22117.1 - 0.03 14.0 0.0 0.057 13.1 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Mannosyl_trans3 PF11051.3 AMD22118.1 - 7.8e-42 143.4 0.0 1.6e-41 142.4 0.0 1.5 1 0 0 1 1 1 1 Mannosyltransferase putative Pkinase PF00069.20 AMD22120.1 - 8.9e-63 211.8 0.0 1.3e-62 211.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22120.1 - 1.6e-31 109.3 0.0 3.9e-31 108.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 AMD22120.1 - 0.0016 18.9 2.4 0.0016 18.9 1.6 2.0 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 AMD22120.1 - 0.09 11.7 0.0 0.24 10.3 0.0 1.6 2 0 0 2 2 2 0 Kinase-like CTP_transf_1 PF01148.15 AMD22121.1 - 1.5e-76 257.4 24.7 2e-76 257.0 17.1 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family DUF2370 PF10176.4 AMD22121.1 - 0.21 10.9 0.6 1.7 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) DUF3449 PF11931.3 AMD22122.1 - 3.6e-66 222.4 0.9 3.8e-64 215.8 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) zf-met PF12874.2 AMD22122.1 - 9.3e-08 32.0 3.5 6.4e-05 23.0 0.1 3.0 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD22122.1 - 2.3e-07 30.7 8.0 5.5e-06 26.3 0.0 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 AMD22122.1 - 0.00018 21.5 3.4 0.051 13.6 0.0 3.2 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 AMD22122.1 - 0.19 12.1 2.8 8.5 6.9 0.0 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF2175 PF09943.4 AMD22122.1 - 7.1 6.7 9.9 3.9 7.5 0.2 3.6 3 2 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2175) DEAD PF00270.24 AMD22123.1 - 4.4e-47 159.7 0.0 8.3e-46 155.5 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase DBP10CT PF08147.7 AMD22123.1 - 5e-21 74.2 5.7 5e-21 74.2 4.0 2.3 2 0 0 2 2 2 1 DBP10CT (NUC160) domain Helicase_C PF00271.26 AMD22123.1 - 1.7e-20 72.6 0.0 5.6e-20 70.9 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Glyco_hydro_1 PF00232.13 AMD22123.1 - 0.021 13.0 0.0 0.042 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 tRNA_Me_trans PF03054.11 AMD22124.1 - 1.5e-112 375.7 0.0 1.7e-112 375.5 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.16 AMD22124.1 - 0.00043 19.8 0.0 0.00068 19.2 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 AMD22124.1 - 0.0016 17.4 0.0 0.023 13.5 0.0 2.1 2 0 0 2 2 2 1 NAD synthase Inositol_P PF00459.20 AMD22125.1 - 5.6e-53 179.9 0.0 8.9e-53 179.3 0.0 1.3 1 1 0 1 1 1 1 Inositol monophosphatase family Git3 PF11710.3 AMD22126.1 - 1.4e-73 246.7 10.6 2.6e-73 245.9 7.3 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 AMD22126.1 - 3.4e-33 113.2 3.1 1.1e-32 111.5 2.2 2.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term SPC12 PF06645.8 AMD22126.1 - 4.8 7.0 8.6 13 5.6 0.1 2.9 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Exo_endo_phos PF03372.18 AMD22127.1 - 2.8e-15 56.9 0.0 7.7e-15 55.4 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PepSY_TM PF03929.11 AMD22127.1 - 0.03 14.6 2.5 0.077 13.4 1.7 1.7 1 0 0 1 1 1 0 PepSY-associated TM helix PseudoU_synth_2 PF00849.17 AMD22128.1 - 1.8e-33 115.6 0.1 3.4e-33 114.8 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.17 AMD22128.1 - 1e-18 66.8 0.0 1.8e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region S4 PF01479.20 AMD22128.1 - 0.04 13.3 0.1 0.44 10.0 0.0 2.6 2 0 0 2 2 2 0 S4 domain XOO_2897-deam PF14440.1 AMD22128.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase NARP1 PF12569.3 AMD22129.1 - 2.4e-112 376.3 25.6 2e-78 264.4 3.5 3.3 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.12 AMD22129.1 - 1.1e-12 46.8 14.8 0.046 13.6 0.0 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.1 AMD22129.1 - 1.3e-12 47.1 2.8 0.016 15.7 0.0 7.5 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 AMD22129.1 - 4.2e-12 46.3 4.9 0.00079 20.0 0.0 5.7 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 AMD22129.1 - 8e-12 44.6 10.6 0.0001 21.9 0.2 6.4 5 1 0 5 5 5 3 TPR repeat TPR_17 PF13431.1 AMD22129.1 - 2.5e-10 39.6 0.8 0.34 11.2 0.0 6.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 AMD22129.1 - 2.9e-10 40.3 8.5 0.024 14.9 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 AMD22129.1 - 5.3e-08 32.6 6.6 0.045 13.6 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 AMD22129.1 - 4.9e-06 26.5 17.1 0.00048 20.2 0.1 5.2 5 1 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 AMD22129.1 - 7.8e-06 25.2 19.2 0.053 13.1 0.1 8.4 10 0 0 10 10 10 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 AMD22129.1 - 0.00017 21.4 6.0 0.65 9.9 0.2 3.9 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 AMD22129.1 - 0.12 12.9 17.9 0.82 10.2 0.1 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat ABC2_membrane PF01061.19 AMD22130.1 - 2.9e-65 219.3 57.7 2.7e-38 131.2 11.7 3.0 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 AMD22130.1 - 9.9e-42 142.4 0.1 3.1e-20 72.8 0.0 3.6 4 0 0 4 4 3 2 ABC transporter PDR_CDR PF06422.7 AMD22130.1 - 1.3e-40 137.2 1.5 1.3e-34 117.9 0.0 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.1 AMD22130.1 - 3.5e-09 36.6 0.0 8.7e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal ABC2_membrane_3 PF12698.2 AMD22130.1 - 6.2e-09 35.3 55.9 4.2e-07 29.3 9.7 3.5 2 1 0 3 3 3 2 ABC-2 family transporter protein AAA_25 PF13481.1 AMD22130.1 - 8.2e-08 31.8 0.0 0.0014 18.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.1 AMD22130.1 - 2.7e-05 24.2 0.7 0.083 12.8 0.2 2.8 2 1 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 AMD22130.1 - 3.2e-05 23.1 0.1 0.0004 19.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 AMD22130.1 - 7.9e-05 22.7 0.0 0.78 9.6 0.0 3.5 3 0 0 3 3 3 1 AAA domain cobW PF02492.14 AMD22130.1 - 0.00011 21.6 0.1 0.0004 19.8 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 AMD22130.1 - 0.00021 20.7 0.2 0.069 12.6 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.14 AMD22130.1 - 0.00032 20.0 0.0 0.11 11.7 0.0 3.4 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 AMD22130.1 - 0.00048 20.2 0.1 0.018 15.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 AMD22130.1 - 0.0019 18.1 0.0 0.26 11.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 AMD22130.1 - 0.0022 18.4 0.0 2.5 8.6 0.0 3.0 3 0 0 3 3 2 1 Miro-like protein FtsK_SpoIIIE PF01580.13 AMD22130.1 - 0.0023 17.4 0.1 2.1 7.7 0.0 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_18 PF13238.1 AMD22130.1 - 0.0055 17.0 0.0 0.18 12.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD22130.1 - 0.011 16.5 0.0 0.28 12.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 AMD22130.1 - 0.015 14.9 0.5 0.099 12.2 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 AMD22130.1 - 0.027 14.1 0.2 0.39 10.3 0.1 2.4 2 0 0 2 2 2 0 NACHT domain SbcCD_C PF13558.1 AMD22130.1 - 0.076 12.9 0.3 2.1 8.3 0.0 2.9 3 0 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.1 AMD22130.1 - 0.077 12.9 0.2 0.2 11.5 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 AMD22130.1 - 0.093 12.1 0.0 0.52 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain Septin PF00735.13 AMD22130.1 - 0.13 11.3 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_33 PF13671.1 AMD22130.1 - 0.15 11.9 0.6 0.89 9.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.1 AMD22130.1 - 0.18 11.3 0.1 3.5 7.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 AMD22130.1 - 1.1 9.0 3.9 19 5.0 0.3 2.8 3 0 0 3 3 2 0 Part of AAA domain Hid1 PF12722.2 AMD22131.1 - 1e-193 645.5 17.5 1.2e-193 645.3 12.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 AMD22131.1 - 3.6e-10 38.6 8.5 2.5e-09 35.8 5.9 2.4 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein WGG PF10273.4 AMD22132.1 - 2.8e-31 107.4 0.4 2.8e-31 107.4 0.3 1.8 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 Vfa1 PF08432.5 AMD22132.1 - 0.15 12.0 2.0 0.22 11.5 1.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NOA36 PF06524.7 AMD22132.1 - 0.45 9.7 6.2 0.59 9.3 4.3 1.1 1 0 0 1 1 1 0 NOA36 protein Metallophos PF00149.23 AMD22133.1 - 1.8e-42 145.0 0.1 2.6e-42 144.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase IMPDH PF00478.20 AMD22134.1 - 1.5e-145 484.5 3.4 1.8e-145 484.2 2.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 AMD22134.1 - 5.4e-17 61.3 0.0 2.5e-07 30.3 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.13 AMD22134.1 - 3.5e-09 35.9 0.5 7.8e-09 34.8 0.4 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.10 AMD22134.1 - 2e-08 33.7 4.6 0.00023 20.4 1.2 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.16 AMD22134.1 - 5.5e-05 22.5 1.4 0.0025 17.1 0.2 2.4 1 1 1 2 2 2 1 Histidine biosynthesis protein Aldolase PF01081.14 AMD22134.1 - 0.0026 16.9 0.5 0.011 14.9 0.0 2.2 2 0 0 2 2 2 1 KDPG and KHG aldolase ThiG PF05690.9 AMD22134.1 - 0.026 13.5 1.8 0.042 12.9 0.6 1.7 1 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG Response_reg PF00072.19 AMD22134.1 - 0.031 14.2 0.0 0.1 12.6 0.0 1.8 1 0 0 1 1 1 0 Response regulator receiver domain EAL PF00563.15 AMD22134.1 - 0.035 13.5 0.2 0.33 10.3 0.0 2.1 2 0 0 2 2 2 0 EAL domain DHO_dh PF01180.16 AMD22134.1 - 1.2 8.0 5.9 0.81 8.5 0.4 2.9 3 0 0 3 3 3 0 Dihydroorotate dehydrogenase SUR7 PF06687.7 AMD22135.1 - 4.2e-08 33.0 20.0 4.2e-08 33.0 13.9 2.1 2 1 0 2 2 2 1 SUR7/PalI family SNARE PF05739.14 AMD22136.1 - 3.8e-17 61.7 2.3 3.8e-17 61.7 1.6 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 AMD22136.1 - 0.00016 21.8 0.2 0.00016 21.8 0.1 2.7 1 1 0 2 2 2 1 Syntaxin DUF3357 PF11837.3 AMD22136.1 - 0.00024 20.9 0.0 0.00056 19.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3357) RNase_H2_suC PF08615.6 AMD22136.1 - 0.007 16.2 0.2 0.025 14.4 0.1 1.8 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) KASH PF10541.4 AMD22136.1 - 0.018 14.8 0.0 0.049 13.4 0.0 1.7 1 0 0 1 1 1 0 Nuclear envelope localisation domain Zot PF05707.7 AMD22136.1 - 0.095 12.1 0.5 0.13 11.6 0.3 1.2 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) TMPIT PF07851.8 AMD22136.1 - 0.41 9.6 7.6 0.043 12.8 2.0 1.7 1 1 0 2 2 2 0 TMPIT-like protein DSPn PF14671.1 AMD22137.1 - 1.4e-49 167.7 0.0 4.3e-49 166.1 0.0 1.9 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 AMD22137.1 - 2.1e-23 82.3 0.1 2.2e-21 75.8 0.0 2.7 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 AMD22137.1 - 0.00011 21.6 0.2 0.00031 20.1 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 AMD22137.1 - 0.0021 17.5 0.1 0.0044 16.4 0.1 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 AMD22137.1 - 0.032 14.3 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 AMD22137.1 - 0.039 14.1 0.1 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family Acetyltransf_13 PF13880.1 AMD22138.1 - 1.5e-20 72.7 0.2 2.8e-20 71.8 0.1 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.1 AMD22138.1 - 6.6e-09 35.1 0.1 1.1e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.19 AMD22138.1 - 0.0011 18.9 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AMD22138.1 - 0.011 15.9 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PHP PF02811.14 AMD22139.1 - 2.2e-19 69.9 0.6 5.1e-19 68.7 0.4 1.6 1 1 0 1 1 1 1 PHP domain ProRS-C_1 PF09180.6 AMD22140.1 - 8.3e-26 89.7 1.1 1.6e-25 88.7 0.8 1.5 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.20 AMD22140.1 - 1.8e-21 76.4 0.1 3.1e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AMD22140.1 - 3.1e-21 75.1 0.0 2.9e-20 72.0 0.0 2.6 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2 PF00152.15 AMD22141.1 - 1.1e-74 251.1 0.0 2.3e-74 250.1 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AMD22141.1 - 6.7e-11 41.8 0.0 1.3e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.6 AMD22141.1 - 0.01 14.8 0.0 0.021 13.8 0.0 1.5 1 0 0 1 1 1 0 Inositol 1, 3, 4-trisphosphate 5/6-kinase Lyase_1 PF00206.15 AMD22142.1 - 2.4e-96 322.6 0.0 3.7e-96 322.0 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 AMD22142.1 - 1.9e-26 91.9 0.0 3.6e-26 91.0 0.0 1.5 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DUF1776 PF08643.5 AMD22143.1 - 6.5e-67 225.7 0.1 1e-66 225.1 0.1 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DUF500 PF04366.7 AMD22144.1 - 6.5e-45 151.6 1.2 1e-44 150.9 0.8 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF500) SH3_9 PF14604.1 AMD22144.1 - 5.1e-13 48.3 0.0 1.1e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 AMD22144.1 - 6.6e-13 47.8 0.0 1.5e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 AMD22144.1 - 1.2e-11 43.8 0.1 4e-11 42.2 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain RRM_1 PF00076.17 AMD22145.1 - 2.3e-47 158.4 8.2 7.1e-18 64.0 0.4 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22145.1 - 6.8e-29 99.6 1.2 9e-10 38.3 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22145.1 - 1.4e-21 76.1 1.0 5e-07 29.4 0.5 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 AMD22145.1 - 5.9e-05 22.8 0.3 0.45 10.4 0.0 3.8 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.1 AMD22145.1 - 0.0066 16.1 0.0 6.5 6.6 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RXT2_N PF08595.6 AMD22145.1 - 0.42 10.3 5.9 0.64 9.8 2.6 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Pkinase PF00069.20 AMD22146.1 - 6.2e-63 212.3 0.0 1e-62 211.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22146.1 - 3.2e-23 82.1 0.0 4.9e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD22146.1 - 0.0033 16.4 0.0 0.0057 15.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD22146.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 AMD22146.1 - 0.047 12.7 0.0 0.087 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 AMD22146.1 - 0.055 13.0 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase CDtoxinA PF03498.9 AMD22146.1 - 0.067 12.5 0.1 13 5.1 0.0 2.3 2 0 0 2 2 2 0 Cytolethal distending toxin A/C family WD40 PF00400.27 AMD22147.1 - 0.011 15.6 0.1 0.051 13.4 0.0 2.2 1 0 0 1 1 1 0 WD domain, G-beta repeat BAR PF03114.13 AMD22148.1 - 3.7e-52 177.1 0.8 4.9e-52 176.7 0.5 1.2 1 0 0 1 1 1 1 BAR domain MgtE_N PF03448.12 AMD22148.1 - 0.054 13.8 1.2 2.6 8.4 0.0 3.2 3 1 0 3 3 3 0 MgtE intracellular N domain UPF0261 PF06792.6 AMD22148.1 - 0.14 10.5 0.2 0.29 9.5 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0261) Grp1_Fun34_YaaH PF01184.14 AMD22149.1 - 1.5e-90 302.1 16.1 1.8e-90 301.8 11.1 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family RNA_pol_Rpc34 PF05158.7 AMD22150.1 - 2.1e-98 329.5 1.9 2.5e-98 329.2 1.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.7 AMD22150.1 - 0.012 15.4 0.7 0.034 14.0 0.1 1.9 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC Rrf2 PF02082.15 AMD22150.1 - 0.031 14.3 0.1 0.066 13.3 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator LSM14 PF12701.2 AMD22150.1 - 0.094 12.5 0.0 3 7.7 0.0 2.7 2 1 0 2 2 2 0 Scd6-like Sm domain ABC2_membrane PF01061.19 AMD22151.1 - 6.8e-36 123.4 15.8 6.8e-36 123.4 10.9 2.5 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.22 AMD22151.1 - 3.2e-26 92.2 0.0 5.5e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AMD22151.1 - 2.2e-06 27.8 0.3 8.8e-06 25.8 0.2 2.0 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 AMD22151.1 - 4.3e-05 22.7 0.3 0.00014 21.0 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 hEGF PF12661.2 AMD22151.1 - 0.0023 17.8 20.7 0.016 15.2 2.0 3.8 3 0 0 3 3 3 2 Human growth factor-like EGF SMC_N PF02463.14 AMD22151.1 - 0.0038 16.4 0.1 0.0091 15.2 0.0 1.6 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 AMD22151.1 - 0.0059 16.0 0.2 0.77 9.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 AMD22151.1 - 0.007 16.3 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.1 AMD22151.1 - 0.068 13.0 0.0 0.17 11.7 0.0 1.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit EGF_2 PF07974.8 AMD22151.1 - 0.072 13.2 0.3 0.072 13.2 0.2 4.8 5 0 0 5 5 4 0 EGF-like domain AAA_22 PF13401.1 AMD22151.1 - 0.076 13.1 0.2 0.28 11.3 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 AMD22151.1 - 0.22 11.0 0.6 0.44 10.1 0.1 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Laminin_EGF PF00053.19 AMD22151.1 - 4 7.4 34.0 0.065 13.1 5.3 3.8 2 2 1 3 3 2 0 Laminin EGF-like (Domains III and V) Peptidase_M28 PF04389.12 AMD22152.1 - 2e-39 135.1 0.0 2.8e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PIP5K PF01504.13 AMD22153.1 - 1.7e-64 217.3 0.6 1.7e-64 217.3 0.4 2.4 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 AMD22153.1 - 1.7e-23 83.0 0.2 3.1e-23 82.1 0.1 1.4 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 AMD22153.1 - 9.2e-17 60.7 12.5 9.2e-17 60.7 8.7 3.4 4 0 0 4 4 4 1 FYVE zinc finger IBR PF01485.16 AMD22153.1 - 0.13 12.2 7.6 0.13 12.1 3.5 2.4 2 0 0 2 2 2 0 IBR domain WD40 PF00400.27 AMD22154.1 - 2.1e-09 36.9 0.0 0.0019 17.9 0.0 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF2890 PF11081.3 AMD22154.1 - 0.059 13.4 0.2 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) CENP-B_dimeris PF09026.5 AMD22154.1 - 7.4 6.8 11.3 15 5.9 7.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Arrestin_C PF02752.17 AMD22155.1 - 2.9e-12 46.8 0.0 9.1e-12 45.2 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 AMD22155.1 - 2e-07 30.9 0.0 3.1e-06 27.0 0.0 2.4 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 AMD22155.1 - 2e-05 24.1 0.0 5.4e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Arrestin_N terminal like Glyco_hydro_16 PF00722.16 AMD22156.1 - 3.7e-47 160.0 3.3 5.6e-47 159.4 2.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 RNA_pol_Rpb4 PF03874.11 AMD22157.1 - 7.3e-28 96.9 0.4 9.3e-28 96.5 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Herpes_LAMP2 PF06126.6 AMD22157.1 - 0.036 12.4 0.0 0.046 12.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 Mad3_BUB1_I PF08311.7 AMD22158.1 - 2.3e-40 137.3 1.5 6.1e-40 135.9 1.0 1.8 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.6 AMD22158.1 - 3.6e-26 90.8 0.1 3.7e-25 87.5 0.0 2.7 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.20 AMD22158.1 - 2.3e-21 76.1 0.0 4.3e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22158.1 - 0.00012 21.2 0.0 0.00023 20.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD22158.1 - 0.015 14.2 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Cpn60_TCP1 PF00118.19 AMD22159.1 - 2.2e-152 508.1 0.8 2.5e-152 507.9 0.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GCN5L1 PF06320.8 AMD22160.1 - 0.082 12.7 0.0 0.097 12.5 0.0 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) DUF4288 PF14119.1 AMD22160.1 - 0.094 12.8 0.2 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) Sad1_UNC PF07738.8 AMD22162.1 - 1.6e-08 34.4 0.2 4.2e-08 33.0 0.1 1.7 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal eIF3_p135 PF12807.2 AMD22162.1 - 0.31 10.9 9.5 4 7.3 1.7 3.1 2 1 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Bot1p PF12298.3 AMD22163.1 - 4.2e-51 173.3 0.4 5.6e-51 172.8 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein BLVR PF06375.6 AMD22163.1 - 0.0089 15.8 0.4 0.024 14.4 0.2 1.8 2 0 0 2 2 2 1 Bovine leukaemia virus receptor (BLVR) Trs65 PF12735.2 AMD22164.1 - 1.8e-36 126.0 2.1 3.5e-36 125.0 0.6 2.0 2 1 0 2 2 2 1 TRAPP trafficking subunit Trs65 Clathrin_lg_ch PF01086.12 AMD22165.1 - 8.6e-42 143.5 13.5 9.1e-42 143.4 9.4 1.0 1 0 0 1 1 1 1 Clathrin light chain Phosducin PF02114.11 AMD22165.1 - 0.014 14.1 4.8 0.015 14.0 3.3 1.2 1 0 0 1 1 1 0 Phosducin DUF89 PF01937.14 AMD22165.1 - 0.049 12.4 2.9 0.054 12.2 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF89 SR-25 PF10500.4 AMD22165.1 - 0.087 12.2 5.4 0.11 11.9 3.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PSII_Pbs27 PF13326.1 AMD22165.1 - 0.17 11.8 2.6 0.33 10.9 1.7 1.5 1 1 0 1 1 1 0 Photosystem II Pbs27 UPF0172 PF03665.8 AMD22165.1 - 0.49 9.8 3.6 0.73 9.2 2.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) DUF2852 PF11014.3 AMD22165.1 - 0.52 10.2 7.0 0.84 9.6 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) MAP7 PF05672.6 AMD22165.1 - 0.67 9.3 16.1 0.95 8.8 11.2 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family DUF3154 PF11351.3 AMD22165.1 - 2.4 7.8 6.1 0.68 9.6 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3154) SH3_1 PF00018.23 AMD22167.1 - 1.7e-05 24.1 1.6 1.9e-05 23.9 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.12 AMD22167.1 - 0.0001 21.7 0.2 0.00047 19.5 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.1 AMD22167.1 - 0.00027 20.4 0.0 0.00062 19.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PseudoU_synth_2 PF00849.17 AMD22168.1 - 2.4e-31 108.8 0.0 3.7e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase YXWGXW PF12779.2 AMD22168.1 - 0.082 12.8 1.3 0.24 11.3 0.9 1.8 1 0 0 1 1 1 0 YXWGXW repeat (2 copies) FSH1 PF03959.8 AMD22170.1 - 4.8e-57 192.8 0.0 5.3e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 AMD22170.1 - 0.00011 21.9 0.0 0.00016 21.4 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.6 AMD22170.1 - 0.00054 19.7 0.2 0.044 13.4 0.0 2.2 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.11 AMD22170.1 - 0.0016 17.9 1.2 0.09 12.2 0.8 2.5 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 AMD22170.1 - 0.015 15.1 0.0 0.35 10.7 0.0 2.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.15 AMD22170.1 - 0.026 14.7 0.0 0.087 13.0 0.0 1.7 1 1 1 2 2 2 0 Thioesterase domain dCMP_cyt_deam_1 PF00383.17 AMD22171.1 - 1.2e-22 79.4 0.4 1.7e-22 78.9 0.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 AMD22171.1 - 3e-05 23.7 0.0 5.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 APOBEC-like N-terminal domain XOO_2897-deam PF14440.1 AMD22171.1 - 0.0012 18.5 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Xanthomonas XOO_2897-like deaminase Bd3614-deam PF14439.1 AMD22171.1 - 0.0045 16.8 0.4 0.037 13.8 0.3 2.2 1 1 0 1 1 1 1 Bd3614-like deaminase MafB19-deam PF14437.1 AMD22171.1 - 0.015 14.9 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 MafB19-like deaminase PX PF00787.19 AMD22172.1 - 2e-22 79.1 0.0 5.2e-22 77.7 0.0 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 AMD22172.1 - 1.7e-05 24.2 13.2 0.0061 15.8 2.2 2.4 2 1 0 2 2 2 2 Vps5 C terminal like Gp-FAR-1 PF05823.7 AMD22172.1 - 0.027 14.4 1.8 0.027 14.4 1.2 2.9 1 1 2 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF848 PF05852.6 AMD22172.1 - 0.044 13.6 8.6 1.2 8.9 0.1 2.7 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) APC2 PF08672.6 AMD22172.1 - 0.06 13.6 0.2 2.3 8.5 0.0 2.8 2 0 0 2 2 2 0 Anaphase promoting complex (APC) subunit 2 Vac_Fusion PF02346.11 AMD22172.1 - 0.78 9.2 6.8 5.5 6.4 0.1 3.9 5 0 0 5 5 5 0 Chordopoxvirus fusion protein BAR PF03114.13 AMD22172.1 - 2.6 7.4 14.3 11 5.4 9.7 2.2 1 1 0 1 1 1 0 BAR domain DPPIV_N PF00930.16 AMD22173.1 - 2e-88 296.3 3.4 2.8e-88 295.8 2.4 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 AMD22173.1 - 1.3e-50 171.6 2.2 2.1e-50 170.9 0.6 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 AMD22173.1 - 2.1e-07 30.8 0.0 9e-07 28.7 0.0 2.1 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 AMD22173.1 - 0.14 11.5 0.0 18 4.6 0.1 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PC_rep PF01851.17 AMD22174.1 - 3.5e-23 80.4 11.6 0.00014 21.8 0.1 8.8 9 0 0 9 9 9 6 Proteasome/cyclosome repeat ATP-synt_C PF00137.16 AMD22175.1 - 2.4e-27 94.6 36.7 7.4e-18 64.2 6.3 2.7 3 0 0 3 3 3 2 ATP synthase subunit C GHMP_kinases_N PF00288.21 AMD22176.1 - 3.1e-13 49.5 0.0 6e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 AMD22176.1 - 0.00052 20.1 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal Peptidase_M16_C PF05193.16 AMD22177.1 - 3.1e-44 150.8 0.0 7.7e-44 149.5 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 AMD22177.1 - 9e-35 119.6 0.8 2.8e-34 118.0 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF1947 PF09183.5 AMD22177.1 - 0.12 12.1 0.7 1.5 8.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) Myosin_head PF00063.16 AMD22178.1 - 3.7e-247 821.8 12.2 3.7e-247 821.8 8.5 3.9 4 2 1 5 5 5 1 Myosin head (motor domain) DUF4201 PF13870.1 AMD22178.1 - 0.00015 21.3 14.3 0.00015 21.3 9.9 9.1 3 2 3 7 7 7 2 Domain of unknown function (DUF4201) Myosin_N PF02736.14 AMD22178.1 - 0.0014 18.2 0.0 0.0035 16.9 0.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain MAPEG PF01124.13 AMD22178.1 - 0.45 10.1 0.1 5.6 6.5 0.0 2.2 2 0 0 2 2 2 0 MAPEG family Ras PF00071.17 AMD22179.1 - 2.1e-24 85.7 0.1 2.3e-19 69.3 0.1 2.3 1 1 1 2 2 2 2 Ras family Miro PF08477.8 AMD22179.1 - 3.7e-13 50.0 0.0 6.2e-12 46.0 0.0 2.3 1 1 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 AMD22179.1 - 1.9e-05 24.1 0.1 3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD22179.1 - 0.034 14.0 0.0 0.48 10.4 0.0 2.5 1 1 1 2 2 2 0 50S ribosome-binding GTPase Peptidase_S10 PF00450.17 AMD22180.1 - 4.4e-95 319.2 0.0 5.7e-95 318.9 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase HIG_1_N PF04588.8 AMD22180.1 - 0.13 12.0 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Hypoxia induced protein conserved region Aminotran_1_2 PF00155.16 AMD22181.1 - 1.4e-18 66.9 0.0 1.9e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 AMD22181.1 - 0.026 13.5 0.1 0.059 12.3 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Phosphorylase PF00343.15 AMD22182.1 - 0 1021.5 0.0 0 1021.3 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase MCM PF00493.18 AMD22183.1 - 7.4e-139 462.1 0.5 7.4e-139 462.1 0.4 1.4 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 AMD22183.1 - 7.3e-18 65.2 2.5 2.8e-17 63.3 0.0 2.8 2 1 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 AMD22183.1 - 3.6e-07 29.5 0.0 1.4e-06 27.6 0.0 1.9 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 AMD22183.1 - 0.0053 16.2 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 AMD22183.1 - 0.0063 16.1 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 AMD22183.1 - 0.054 13.2 0.0 0.15 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SKN1 PF03935.10 AMD22184.1 - 7.2e-248 822.7 1.5 8.4e-248 822.5 1.0 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.16 AMD22184.1 - 8.6e-05 21.9 0.8 0.016 14.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl hydrolases family 16 SIS PF01380.17 AMD22185.1 - 1.9e-11 43.6 0.0 3.2e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.1 AMD22185.1 - 7.8e-06 25.6 0.0 0.1 12.2 0.0 2.3 1 1 1 2 2 2 2 SIS domain Herpes_UL25 PF01499.11 AMD22185.1 - 0.12 10.6 0.4 0.2 9.9 0.0 1.4 2 0 0 2 2 2 0 Herpesvirus UL25 family DNA_pol3_tau_4 PF12168.3 AMD22186.1 - 0.89 10.0 10.2 0.23 11.8 4.4 2.0 2 1 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding NpwBP PF12622.2 AMD22187.1 - 0.22 12.0 1.7 0.66 10.5 1.2 1.9 1 0 0 1 1 1 0 mRNA biogenesis factor Actin PF00022.14 AMD22188.1 - 6.7e-23 80.7 0.0 3.8e-12 45.3 0.0 2.4 1 1 1 2 2 2 2 Actin Shufflon_N PF04917.7 AMD22188.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Serinc PF03348.10 AMD22189.1 - 1.6e-139 465.3 16.9 2e-139 465.0 11.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Peptidase_M24 PF00557.19 AMD22191.1 - 3.3e-09 36.6 0.2 5.8e-08 32.5 0.0 2.2 2 0 0 2 2 2 2 Metallopeptidase family M24 E1_dh PF00676.15 AMD22192.1 - 1.1e-120 401.8 0.2 1.7e-120 401.2 0.2 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 AMD22192.1 - 0.00094 18.1 0.0 0.0017 17.3 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.1 AMD22192.1 - 0.051 14.2 0.1 0.051 14.2 0.1 3.1 2 2 1 3 3 3 0 KRTAP type 7 family Ste5_C PF12194.3 AMD22193.1 - 1.8e-71 239.7 4.9 3.8e-71 238.7 3.4 1.5 1 0 0 1 1 1 1 Protein kinase Fus3-binding zf-RING_2 PF13639.1 AMD22193.1 - 0.00047 19.9 6.4 0.0009 19.0 4.5 1.5 1 0 0 1 1 1 1 Ring finger domain PH_10 PF15411.1 AMD22193.1 - 0.042 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain B12-binding PF02310.14 AMD22193.1 - 0.05 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain PH_4 PF15404.1 AMD22194.1 - 7.8e-63 211.3 0.0 1.4e-62 210.5 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Spo7_2_N PF15407.1 AMD22194.1 - 2.5e-18 65.2 0.0 6.9e-18 63.8 0.0 1.8 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.24 AMD22194.1 - 1.2e-08 35.0 0.1 0.00035 20.7 0.0 4.1 4 1 0 4 4 4 2 PH domain COPI_assoc PF08507.5 AMD22195.1 - 6.6e-28 97.1 7.9 7.4e-28 96.9 5.5 1.0 1 0 0 1 1 1 1 COPI associated protein 14-3-3 PF00244.15 AMD22196.1 - 7.5e-116 385.2 4.3 8.7e-116 385.0 3.0 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.6 AMD22196.1 - 0.022 14.6 0.2 0.06 13.2 0.1 1.7 1 0 0 1 1 1 0 Flagellar protein FlaF DUF885 PF05960.6 AMD22196.1 - 0.046 12.8 1.4 0.058 12.5 0.3 1.5 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF885) SPACA7 PF15307.1 AMD22196.1 - 0.12 12.4 3.5 8.9 6.4 0.0 3.0 2 1 0 3 3 3 0 Sperm acrosome-associated protein 7 Glutaredoxin PF00462.19 AMD22197.1 - 3.2e-19 68.6 0.1 1.4e-17 63.4 0.0 2.7 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin PF00085.15 AMD22197.1 - 7.4e-15 54.5 0.0 1.4e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 AMD22197.1 - 6.8e-08 32.5 0.2 3.7e-05 23.7 0.0 2.5 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.16 AMD22197.1 - 7.1e-05 22.4 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.1 AMD22197.1 - 0.0031 17.6 0.1 0.025 14.7 0.0 2.4 2 2 0 2 2 2 1 Thioredoxin-like domain HyaE PF07449.6 AMD22197.1 - 0.075 12.9 0.0 0.94 9.4 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE ArsC PF03960.10 AMD22197.1 - 0.095 12.7 0.0 0.56 10.3 0.0 2.1 2 0 0 2 2 2 0 ArsC family Thioredoxin_7 PF13899.1 AMD22197.1 - 0.13 12.3 0.0 0.43 10.6 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin-like Rad17 PF03215.10 AMD22198.1 - 3.3e-87 293.3 1.0 5.4e-64 216.7 0.0 2.1 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 AMD22198.1 - 0.0094 15.9 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 AMD22198.1 - 0.014 15.1 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 AMD22198.1 - 0.014 15.5 0.0 0.049 13.8 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 AMD22198.1 - 0.023 13.6 0.0 0.043 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.1 AMD22198.1 - 0.024 14.1 0.1 0.056 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RuvB_N PF05496.7 AMD22198.1 - 0.078 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 AMD22198.1 - 0.1 12.8 0.0 0.41 10.8 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.1 AMD22198.1 - 0.1 12.7 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 AMD22198.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_17 PF13207.1 AMD22198.1 - 0.13 13.1 0.0 1.3 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 AMD22198.1 - 0.16 12.2 0.4 0.53 10.5 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Sec63 PF02889.11 AMD22199.1 - 5e-168 558.1 12.0 9.9e-90 300.9 0.3 2.9 3 0 0 3 3 3 2 Sec63 Brl domain DEAD PF00270.24 AMD22199.1 - 3.2e-48 163.4 0.0 3.9e-32 111.0 0.1 3.6 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22199.1 - 8.1e-10 38.4 0.0 6.1e-09 35.6 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD22199.1 - 1.2e-09 38.2 0.0 1.2e-09 38.2 0.0 3.9 4 1 1 5 5 5 2 Type III restriction enzyme, res subunit AAA_22 PF13401.1 AMD22199.1 - 1.4e-06 28.4 1.8 0.064 13.3 0.0 4.4 4 0 0 4 4 4 2 AAA domain DUF1227 PF06777.6 AMD22200.1 - 2.6e-58 195.8 3.5 3.4e-58 195.4 1.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 AMD22200.1 - 6e-51 172.2 5.0 6e-51 172.2 3.4 1.8 2 0 0 2 2 2 1 DEAD_2 Helicase_C_2 PF13307.1 AMD22200.1 - 1.2e-44 152.1 0.0 4.2e-44 150.4 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD PF00270.24 AMD22200.1 - 0.0014 18.1 0.3 1.1 8.7 0.0 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase SNF2_N PF00176.18 AMD22200.1 - 0.0076 15.0 1.9 0.48 9.1 0.1 2.9 2 1 1 3 3 3 1 SNF2 family N-terminal domain ResIII PF04851.10 AMD22200.1 - 0.03 14.1 3.9 0.096 12.5 0.3 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit ADK PF00406.17 AMD22201.1 - 2e-38 131.6 0.0 2.4e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 AMD22201.1 - 2.6e-13 49.3 0.0 4.3e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.1 AMD22201.1 - 0.00055 20.7 0.0 0.0018 19.0 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 AMD22201.1 - 0.00068 19.5 0.0 0.0041 16.9 0.0 2.0 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 AMD22201.1 - 0.0078 15.3 0.0 0.022 13.8 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.1 AMD22201.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain MutS_V PF00488.16 AMD22202.1 - 7.9e-76 254.5 0.0 1.2e-75 253.9 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 AMD22202.1 - 1e-42 146.2 0.2 1.7e-42 145.5 0.1 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 AMD22202.1 - 7.3e-32 109.7 0.0 1.8e-31 108.4 0.0 1.7 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.13 AMD22202.1 - 3.8e-15 55.8 0.1 1e-14 54.4 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 AMD22202.1 - 7.6e-13 48.7 0.0 1.8e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.1 AMD22202.1 - 0.032 13.7 0.0 0.1 12.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain JmjC PF02373.17 AMD22203.1 - 3.1e-40 136.9 2.3 7.6e-40 135.7 1.0 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.12 AMD22203.1 - 9.2e-12 44.2 2.4 9.2e-12 44.2 1.6 2.3 2 0 0 2 2 2 1 jmjN domain zf-C2H2 PF00096.21 AMD22203.1 - 2.1e-07 30.8 16.4 0.00089 19.4 2.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD22203.1 - 2.3e-07 30.7 11.7 3.5e-07 30.1 4.7 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 AMD22203.1 - 6.5e-07 29.2 13.2 0.0012 19.0 1.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AMD22203.1 - 0.0047 16.7 10.4 0.037 13.9 3.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger HypA PF01155.14 AMD22203.1 - 0.15 11.7 0.2 0.28 10.8 0.2 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-C2H2_jaz PF12171.3 AMD22203.1 - 0.55 10.4 15.7 0.074 13.2 3.2 3.0 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 AMD22203.1 - 0.65 9.9 6.7 4 7.4 4.7 2.2 1 1 0 1 1 1 0 Zinc ribbon domain zf-met PF12874.2 AMD22203.1 - 6.7 7.0 9.3 23 5.3 0.5 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PolyA_pol PF01743.15 AMD22204.1 - 2.4e-23 82.7 0.0 4.1e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 AMD22204.1 - 1.5e-05 24.4 0.0 3.5e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A Pox_I1 PF03289.8 AMD22204.1 - 0.0088 14.9 1.4 0.055 12.3 0.1 2.6 2 1 1 3 3 3 1 Poxvirus protein I1 tRNA_NucTran2_2 PF13735.1 AMD22204.1 - 0.016 15.0 0.4 3.3 7.5 0.1 2.4 1 1 1 2 2 2 0 tRNA nucleotidyltransferase domain 2 putative DUF4021 PF13213.1 AMD22205.1 - 0.13 11.8 3.9 0.24 11.0 0.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4021) E1-E2_ATPase PF00122.15 AMD22206.1 - 3.7e-17 62.1 0.0 1.1e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 AMD22206.1 - 3.4e-13 49.3 0.0 8.9e-13 48.0 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 AMD22206.1 - 1.9e-12 48.0 0.1 1.4e-10 41.9 0.0 3.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AMD22206.1 - 2.7e-12 47.2 0.2 1.1e-11 45.2 0.2 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AMD22206.1 - 0.00095 18.8 0.1 0.0025 17.4 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Tox-GHH2 PF15635.1 AMD22206.1 - 0.23 11.8 1.0 0.5 10.7 0.7 1.5 1 0 0 1 1 1 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin 2 YwiC PF14256.1 AMD22206.1 - 2 8.5 13.3 30 4.7 3.3 3.7 3 1 0 3 3 3 0 YwiC-like protein UQ_con PF00179.21 AMD22207.1 - 8e-47 158.1 0.0 9.1e-47 158.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 AMD22207.1 - 7.2e-05 22.5 0.0 9.4e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 AMD22207.1 - 0.0057 16.3 0.1 0.0097 15.5 0.1 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 AMD22207.1 - 0.01 15.7 0.1 0.012 15.4 0.1 1.2 1 0 0 1 1 1 0 RWD domain RRM_1 PF00076.17 AMD22208.1 - 7.7e-87 284.9 3.3 9.6e-21 73.2 0.1 4.7 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22208.1 - 1.1e-58 195.0 0.1 1.4e-15 56.9 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22208.1 - 2.8e-50 167.9 0.0 4.5e-11 42.4 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 AMD22208.1 - 4.7e-22 77.4 2.4 2.7e-21 74.9 0.2 2.8 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_3 PF08777.6 AMD22208.1 - 3.6e-07 29.9 10.6 0.42 10.4 0.1 5.1 4 1 1 5 5 5 3 RNA binding motif OB_RNB PF08206.6 AMD22208.1 - 0.0059 16.0 1.9 10 5.7 0.1 3.5 3 0 0 3 3 3 2 Ribonuclease B OB domain PNPase PF03726.9 AMD22208.1 - 0.031 14.5 4.5 0.054 13.7 0.2 3.0 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF4523 PF15023.1 AMD22208.1 - 0.038 13.5 0.0 0.87 9.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) PAT1 PF09770.4 AMD22208.1 - 4.8 5.3 22.0 6.8 4.7 15.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SNF2_N PF00176.18 AMD22209.1 - 7.6e-74 248.1 0.1 1.6e-73 247.1 0.1 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4208 PF13907.1 AMD22209.1 - 7e-26 90.3 0.7 7e-26 90.3 0.5 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Chromo PF00385.19 AMD22209.1 - 9.4e-21 73.2 3.4 8.9e-13 47.7 0.1 3.2 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 AMD22209.1 - 2.1e-15 56.3 0.0 7.4e-15 54.5 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Myb_DNA-binding PF00249.26 AMD22209.1 - 0.00023 21.1 0.0 0.00074 19.5 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD22209.1 - 0.00024 21.1 0.0 0.002 18.2 0.0 2.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ABC_tran PF00005.22 AMD22210.1 - 6.7e-34 117.1 0.0 3e-16 59.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.10 AMD22210.1 - 1.2e-14 53.5 6.5 2.9e-14 52.3 4.5 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.1 AMD22210.1 - 5.9e-14 52.7 8.4 0.00087 19.3 0.9 4.3 2 2 1 3 3 3 3 AAA domain SMC_N PF02463.14 AMD22210.1 - 2.5e-09 36.6 3.2 0.019 14.1 0.3 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 AMD22210.1 - 7.5e-09 35.1 0.1 0.035 13.1 0.0 4.0 3 1 1 4 4 4 2 AAA ATPase domain Fer4 PF00037.22 AMD22210.1 - 2.7e-08 33.0 2.8 2.7e-08 33.0 2.0 2.6 3 0 0 3 3 2 1 4Fe-4S binding domain DUF258 PF03193.11 AMD22210.1 - 5.2e-06 25.7 2.1 0.039 13.1 0.0 3.1 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA PF00004.24 AMD22210.1 - 9.1e-06 25.9 0.0 0.033 14.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 AMD22210.1 - 1.9e-05 24.0 0.4 0.13 11.7 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 AMD22210.1 - 2.9e-05 24.2 0.0 0.051 13.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD22210.1 - 4.2e-05 24.3 0.3 0.26 12.1 0.0 2.9 2 2 0 2 2 2 2 AAA domain Fer4_6 PF12837.2 AMD22210.1 - 7.8e-05 22.3 12.9 0.00038 20.2 2.1 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_16 PF13191.1 AMD22210.1 - 0.00012 22.1 0.0 0.024 14.6 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain VirE PF05272.6 AMD22210.1 - 0.00019 20.9 0.0 0.7 9.3 0.0 2.5 2 0 0 2 2 2 2 Virulence-associated protein E Fer4_7 PF12838.2 AMD22210.1 - 0.00021 21.6 0.4 0.00021 21.6 0.3 2.6 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 AMD22210.1 - 0.00023 20.8 2.3 0.00023 20.8 1.6 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.1 AMD22210.1 - 0.00027 20.7 12.3 0.00054 19.7 8.5 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Miro PF08477.8 AMD22210.1 - 0.00034 21.0 0.0 0.66 10.4 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein NB-ARC PF00931.17 AMD22210.1 - 0.0005 19.0 0.1 0.14 10.9 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.1 AMD22210.1 - 0.00068 19.9 0.1 1.3 9.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.1 AMD22210.1 - 0.0011 18.3 0.0 0.65 9.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.1 AMD22210.1 - 0.0016 18.2 1.2 0.0016 18.2 0.9 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.1 AMD22210.1 - 0.0018 18.9 0.1 0.0018 18.9 0.1 2.7 3 0 0 3 3 2 1 4Fe-4S double cluster binding domain AAA_28 PF13521.1 AMD22210.1 - 0.002 18.1 0.0 0.61 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 AMD22210.1 - 0.0021 17.7 1.1 0.3 10.7 0.0 2.5 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.17 AMD22210.1 - 0.0026 17.9 0.0 0.83 9.8 0.0 2.8 2 0 0 2 2 2 1 RNA helicase MobB PF03205.9 AMD22210.1 - 0.003 17.2 0.8 0.62 9.7 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 AMD22210.1 - 0.0037 17.1 0.0 0.76 9.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 AMD22210.1 - 0.0045 16.4 2.3 0.26 10.6 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_9 PF13187.1 AMD22210.1 - 0.0053 16.9 2.1 0.0053 16.9 1.4 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.2 AMD22210.1 - 0.0058 17.1 4.2 0.0058 17.1 2.9 2.5 2 0 0 2 2 1 1 4Fe-4S binding domain SbcCD_C PF13558.1 AMD22210.1 - 0.0075 16.1 0.0 9.4 6.2 0.0 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit UPF0079 PF02367.12 AMD22210.1 - 0.0086 15.7 0.1 0.12 11.9 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_5 PF07728.9 AMD22210.1 - 0.013 15.2 0.5 0.17 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 AMD22210.1 - 0.021 14.4 0.0 0.55 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 AMD22210.1 - 0.024 14.5 0.0 7.2 6.5 0.0 2.9 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 AMD22210.1 - 0.044 12.6 0.2 0.11 11.3 0.0 1.7 2 0 0 2 2 1 0 Type II/IV secretion system protein AAA_23 PF13476.1 AMD22210.1 - 0.046 14.0 0.1 0.046 14.0 0.1 3.1 2 1 0 2 2 1 0 AAA domain PduV-EutP PF10662.4 AMD22210.1 - 0.054 12.9 0.9 0.24 10.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 AMD22210.1 - 0.059 12.9 0.4 1.2 8.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_17 PF13534.1 AMD22210.1 - 0.063 13.6 0.2 0.063 13.6 0.1 2.6 2 0 0 2 2 1 0 4Fe-4S dicluster domain Rad17 PF03215.10 AMD22210.1 - 0.069 11.8 0.0 1.1 7.8 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 AMD22210.1 - 0.079 12.6 0.0 5 6.7 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase MMR_HSR1 PF01926.18 AMD22210.1 - 0.086 12.8 0.0 13 5.8 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Fer4_8 PF13183.1 AMD22210.1 - 0.1 12.6 8.4 0.082 12.9 0.9 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Thymidylate_kin PF02223.12 AMD22210.1 - 0.12 11.7 0.3 21 4.4 0.0 2.8 3 0 0 3 3 2 0 Thymidylate kinase DUF815 PF05673.8 AMD22210.1 - 0.13 11.1 0.0 5.1 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TrwB_AAD_bind PF10412.4 AMD22210.1 - 0.22 10.0 0.1 10 4.6 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Fer4_4 PF12800.2 AMD22210.1 - 0.58 10.6 14.3 0.12 12.7 2.1 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain AAA_13 PF13166.1 AMD22210.1 - 0.97 7.8 0.0 0.97 7.8 0.0 2.3 4 0 0 4 4 3 0 AAA domain Phosphodiest PF01663.17 AMD22211.1 - 5.8e-12 45.6 0.1 1e-11 44.7 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 AMD22211.1 - 2.5e-05 23.7 0.1 4.1e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 AMD22211.1 - 0.055 12.6 0.1 0.12 11.4 0.1 1.6 1 0 0 1 1 1 0 Sulfatase Aminotran_1_2 PF00155.16 AMD22212.1 - 1e-67 228.6 0.0 1.4e-67 228.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 AMD22212.1 - 0.00099 17.9 0.0 0.0016 17.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 AMD22212.1 - 0.0069 15.5 0.0 0.0096 15.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1 PF01276.15 AMD22212.1 - 0.018 13.6 0.0 0.027 13.0 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Acetyltransf_1 PF00583.19 AMD22213.1 - 1e-08 35.1 0.0 1.4e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AMD22213.1 - 3.2e-08 33.6 0.0 6.7e-08 32.5 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AMD22213.1 - 3.5e-07 30.1 0.0 0.00013 21.8 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 AMD22213.1 - 0.00053 19.9 0.0 0.00084 19.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AMD22213.1 - 0.015 15.2 0.2 0.026 14.4 0.2 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 AMD22213.1 - 0.11 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein FTR1 PF03239.9 AMD22214.1 - 7.7e-91 304.2 6.6 9e-91 303.9 4.6 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family PrgI PF12666.2 AMD22214.1 - 0.024 14.7 0.4 0.024 14.7 0.3 3.3 4 0 0 4 4 4 0 PrgI family protein LSM PF01423.17 AMD22215.1 - 2.9e-18 65.1 0.2 3.5e-18 64.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain Glyco_transf_20 PF00982.16 AMD22217.1 - 1.1e-148 495.6 0.1 1.5e-148 495.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 AMD22217.1 - 1.3e-81 272.9 0.0 2.2e-81 272.2 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Cohesin_load PF10345.4 AMD22218.1 - 2.1e-85 287.1 20.8 2.6e-85 286.8 14.4 1.0 1 0 0 1 1 1 1 Cohesin loading factor BRO1 PF03097.13 AMD22218.1 - 0.0041 15.9 1.0 0.092 11.4 0.1 2.3 2 0 0 2 2 2 2 BRO1-like domain IL10 PF00726.12 AMD22218.1 - 0.024 13.9 2.7 0.053 12.8 0.0 2.9 3 1 1 4 4 4 0 Interleukin 10 TBP PF00352.16 AMD22219.1 - 5e-70 230.9 0.1 2.4e-35 119.7 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 AMD22219.1 - 0.00014 21.8 0.1 0.61 10.1 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF3378) Rootletin PF15035.1 AMD22220.1 - 0.21 11.5 17.1 0.016 15.1 4.5 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion MscS_porin PF12795.2 AMD22220.1 - 0.83 8.9 17.2 1.4 8.1 0.4 3.1 2 1 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF4441 PF14536.1 AMD22220.1 - 1.8 8.5 7.3 59 3.6 3.7 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4441) Metallophos PF00149.23 AMD22221.1 - 9e-42 142.7 0.6 1.1e-41 142.4 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 AMD22221.1 - 0.00034 20.4 0.0 0.00047 20.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain KaiC PF06745.8 AMD22222.1 - 3.7e-07 29.4 0.1 1.2e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.1 AMD22222.1 - 1.2e-05 24.8 0.0 2.7e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 AMD22222.1 - 2.7e-05 23.8 0.0 4.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad51 PF08423.6 AMD22222.1 - 7e-05 21.8 0.1 0.00092 18.1 0.1 2.0 1 1 0 1 1 1 1 Rad51 RecA PF00154.16 AMD22222.1 - 0.0006 18.9 0.0 0.001 18.2 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein DnaB_C PF03796.10 AMD22222.1 - 0.0013 17.6 0.1 0.0041 16.0 0.0 1.8 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Arch_ATPase PF01637.13 AMD22222.1 - 0.0018 18.0 0.5 0.0049 16.5 0.0 2.0 2 1 0 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 AMD22222.1 - 0.0068 16.5 0.0 0.014 15.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 AMD22222.1 - 0.012 15.8 0.0 0.05 13.7 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 AMD22222.1 - 0.038 13.4 0.0 0.074 12.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.1 AMD22222.1 - 0.056 13.0 0.1 0.12 11.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 AMD22222.1 - 0.078 12.8 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain UCH PF00443.24 AMD22224.1 - 7.3e-54 182.6 8.3 2e-53 181.2 5.8 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD22224.1 - 3e-08 33.4 3.0 3e-08 33.4 2.1 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MgtE_N PF03448.12 AMD22224.1 - 0.036 14.3 0.2 0.074 13.3 0.1 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain SWIM PF04434.12 AMD22225.1 - 0.0038 16.6 0.8 0.077 12.4 0.1 2.3 2 0 0 2 2 2 2 SWIM zinc finger PET122 PF05476.6 AMD22226.1 - 9.4e-52 175.8 9.5 1.2e-51 175.5 6.6 1.0 1 0 0 1 1 1 1 PET122 60KD_IMP PF02096.15 AMD22227.1 - 5.9e-36 123.9 0.7 5.9e-36 123.9 0.5 1.8 2 0 0 2 2 2 1 60Kd inner membrane protein RhoGAP PF00620.22 AMD22228.1 - 2.7e-38 130.9 0.2 1.3e-37 128.7 0.0 2.3 2 0 0 2 2 2 1 RhoGAP domain RasGEF PF00617.14 AMD22228.1 - 3.3e-23 82.3 0.1 6.2e-22 78.2 0.0 2.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 AMD22228.1 - 3.1e-15 56.1 2.8 2.1e-14 53.4 0.9 3.0 2 0 0 2 2 2 1 RasGEF N-terminal motif PH PF00169.24 AMD22228.1 - 0.00026 21.1 1.2 0.0005 20.2 0.1 2.1 2 0 0 2 2 2 1 PH domain UPF0160 PF03690.8 AMD22229.1 - 3.3e-125 417.7 0.0 3.7e-125 417.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) CR6_interact PF10147.4 AMD22230.1 - 0.036 13.3 0.8 0.045 13.0 0.5 1.1 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF1947 PF09183.5 AMD22230.1 - 0.49 10.1 2.3 0.28 10.9 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) Cwf_Cwc_15 PF04889.7 AMD22230.1 - 1.2 8.7 5.6 1.6 8.4 3.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sec34 PF04136.10 AMD22231.1 - 6.1e-22 78.0 7.8 6.1e-22 78.0 5.4 2.6 3 0 0 3 3 3 1 Sec34-like family HycH PF07450.6 AMD22231.1 - 0.048 13.7 1.3 2 8.5 0.1 2.9 3 0 0 3 3 3 0 Formate hydrogenlyase maturation protein HycH Tbf5 PF06331.7 AMD22232.1 - 1.8e-26 91.6 0.0 2.1e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Clathrin PF00637.15 AMD22233.1 - 5.5e-27 94.1 0.8 5.5e-27 94.1 0.6 3.1 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.4 AMD22233.1 - 9.4e-06 25.6 1.4 2.1e-05 24.5 0.1 2.3 2 1 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 DUF504 PF04457.7 AMD22233.1 - 0.00017 21.6 0.0 0.00042 20.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF504) WD40 PF00400.27 AMD22233.1 - 0.0019 17.9 0.5 0.0068 16.2 0.3 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat CENP-B_dimeris PF09026.5 AMD22233.1 - 0.64 10.2 8.9 0.061 13.5 2.2 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DDE_1 PF03184.14 AMD22234.1 - 1.3e-65 220.5 0.2 2.5e-65 219.6 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 AMD22234.1 - 7.1e-12 44.9 0.1 2.5e-11 43.1 0.1 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_32 PF13565.1 AMD22234.1 - 0.055 14.2 0.1 0.21 12.4 0.0 2.1 1 0 0 1 1 1 0 Homeodomain-like domain Stn1 PF10451.4 AMD22235.1 - 2.1e-37 128.3 0.7 3.3e-37 127.7 0.5 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.2 AMD22235.1 - 4.2e-19 68.6 0.8 4.2e-19 68.6 0.6 2.2 2 0 0 2 2 2 1 Telomere capping C-terminal wHTH Intein_splicing PF14890.1 AMD22235.1 - 0.015 14.2 0.2 0.023 13.5 0.2 1.3 1 0 0 1 1 1 0 Intein splicing domain tRNA_anti-codon PF01336.20 AMD22235.1 - 0.04 13.7 0.3 0.14 12.0 0.1 2.0 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain Methyltransf_8 PF05148.10 AMD22236.1 - 4.4e-67 225.9 1.6 3e-65 219.9 0.2 2.6 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_11 PF08241.7 AMD22236.1 - 3.5e-08 33.8 0.0 1.5e-07 31.7 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD22236.1 - 0.00024 20.6 0.1 0.0071 15.9 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 AMD22236.1 - 0.031 13.9 0.5 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 AMD22236.1 - 0.086 12.2 0.0 7.2 5.9 0.0 2.5 1 1 1 2 2 2 0 Methyltransferase small domain DUF846 PF05832.7 AMD22237.1 - 1.1e-43 148.3 3.6 1.3e-43 148.0 2.5 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Mannosyl_trans3 PF11051.3 AMD22238.1 - 1.2e-68 231.4 1.0 1.7e-68 230.9 0.7 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative OCC1 PF15506.1 AMD22239.1 - 5 7.0 7.4 0.7 9.8 1.7 2.2 2 0 0 2 2 2 0 OCC1 family SSF PF00474.12 AMD22240.1 - 6.4e-06 25.0 35.6 8.9e-05 21.2 24.7 2.3 1 1 0 1 1 1 1 Sodium:solute symporter family CBFD_NFYB_HMF PF00808.18 AMD22241.1 - 4e-12 46.0 0.2 7.1e-12 45.2 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 AMD22241.1 - 0.0031 17.6 0.0 0.0046 17.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 EVI2A PF05399.6 AMD22241.1 - 0.049 12.8 0.0 0.053 12.7 0.0 1.0 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) SecE PF00584.15 AMD22242.1 - 2e-10 40.0 0.0 2.2e-10 39.9 0.0 1.0 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Nop52 PF05997.7 AMD22243.1 - 1.3e-66 224.1 4.4 1.5e-66 223.9 3.1 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.3 AMD22243.1 - 0.0034 17.1 0.2 0.012 15.3 0.0 1.9 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair DUF600 PF04634.7 AMD22243.1 - 0.013 15.5 0.9 0.025 14.5 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF600 E3_binding PF02817.12 AMD22243.1 - 0.16 11.6 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 e3 binding domain Slu7 PF11708.3 AMD22244.1 - 4.8e-30 105.0 3.4 5.9e-30 104.7 2.4 1.1 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.18 AMD22244.1 - 0.019 14.8 1.4 0.019 14.8 1.0 1.7 2 0 0 2 2 2 0 Zinc knuckle SPX PF03105.14 AMD22245.1 - 7.2e-08 32.5 4.8 0.00012 21.9 0.2 2.3 2 0 0 2 2 2 2 SPX domain SPT2 PF08243.6 AMD22246.1 - 2e-27 95.7 26.2 2e-27 95.7 18.2 3.0 2 1 1 3 3 3 2 SPT2 chromatin protein Rad4 PF03835.10 AMD22247.1 - 2.5e-32 111.2 1.6 5.5e-32 110.1 1.1 1.6 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 AMD22247.1 - 3.1e-26 90.9 1.6 3.6e-26 90.6 0.2 1.8 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 AMD22247.1 - 3.5e-17 61.6 0.0 2e-16 59.2 0.0 2.2 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 AMD22247.1 - 1.7e-10 41.0 0.0 7.7e-10 38.9 0.0 2.3 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 AMD22247.1 - 4e-05 23.7 0.0 0.00013 22.1 0.0 1.9 2 0 0 2 2 2 1 Transglutaminase-like superfamily CK_II_beta PF01214.13 AMD22248.1 - 5.5e-70 234.6 0.0 7e-70 234.2 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HSCB_C PF07743.8 AMD22249.1 - 2.5e-11 43.8 5.3 4e-11 43.2 3.6 1.3 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 AMD22249.1 - 2.8e-07 30.1 0.1 4.2e-06 26.4 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain MatP PF06303.7 AMD22249.1 - 0.017 15.0 0.6 0.025 14.4 0.4 1.2 1 0 0 1 1 1 0 Organiser of macrodomain of Terminus of chromosome DNAPolymera_Pol PF11590.3 AMD22249.1 - 0.26 11.0 0.0 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase catalytic subunit Pol ATE_C PF04377.10 AMD22250.1 - 1.8e-43 147.6 0.5 4.3e-43 146.4 0.4 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 AMD22250.1 - 1.3e-24 85.7 3.3 3.5e-24 84.4 2.3 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Aminotran_1_2 PF00155.16 AMD22252.1 - 2.1e-14 53.2 0.0 3.1e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II WD40 PF00400.27 AMD22253.1 - 2.1e-38 128.8 13.0 2e-10 40.1 0.0 8.5 8 0 0 8 8 8 5 WD domain, G-beta repeat Hira PF07569.6 AMD22253.1 - 8.5e-11 41.4 0.0 2.5e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 TUP1-like enhancer of split HIRA_B PF09453.5 AMD22253.1 - 1.9e-06 27.2 0.0 4.3e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 HIRA B motif eIF2A PF08662.6 AMD22253.1 - 0.022 14.5 0.3 2.7 7.6 0.0 4.0 4 1 1 5 5 5 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 AMD22253.1 - 0.037 13.6 0.1 25 4.6 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Aconitase PF00330.15 AMD22254.1 - 1.9e-185 616.7 0.0 2.4e-185 616.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 AMD22254.1 - 2.7e-44 150.4 0.0 6.4e-44 149.2 0.0 1.7 1 0 0 1 1 1 1 Aconitase C-terminal domain SH3_1 PF00018.23 AMD22255.1 - 3e-37 125.7 9.6 2.3e-14 52.5 0.0 4.6 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.1 AMD22255.1 - 1.5e-32 110.9 8.4 1.1e-10 40.8 0.2 4.5 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.12 AMD22255.1 - 7e-32 108.7 0.4 1.3e-11 43.8 0.0 4.4 4 0 0 4 4 4 4 Variant SH3 domain SHD1 PF03983.7 AMD22255.1 - 1.5e-30 104.6 0.6 2.8e-30 103.7 0.4 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 DUF3104 PF11302.3 AMD22255.1 - 0.02 14.2 0.1 0.057 12.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) IRS PF02174.12 AMD22255.1 - 0.18 11.3 0.0 0.37 10.4 0.0 1.4 1 0 0 1 1 1 0 PTB domain (IRS-1 type) DUF962 PF06127.6 AMD22256.1 - 8.5e-25 86.4 2.5 2.5e-24 84.9 1.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF4257 PF14074.1 AMD22256.1 - 0.036 13.7 1.6 0.041 13.5 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4257) Proteasome PF00227.21 AMD22257.1 - 1.5e-45 154.7 0.0 2.2e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 AMD22257.1 - 1.6e-15 56.1 0.1 3.3e-15 55.0 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Rsc14 PF08586.5 AMD22258.1 - 4e-38 129.9 0.2 5.6e-38 129.4 0.1 1.2 1 0 0 1 1 1 1 RSC complex, Rsc14/Ldb7 subunit ERG4_ERG24 PF01222.12 AMD22259.1 - 2.8e-162 540.1 24.5 3.2e-162 539.9 17.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family CytoC_RC PF02276.13 AMD22259.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Photosynthetic reaction centre cytochrome C subunit DUF485 PF04341.7 AMD22259.1 - 8 6.2 10.6 7.1 6.4 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function, DUF485 PUF PF00806.14 AMD22260.1 - 7.3e-61 198.3 12.4 1e-08 34.1 0.5 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Toxin_17 PF08086.6 AMD22260.1 - 0.63 10.1 5.1 1.5 8.9 3.5 1.6 1 0 0 1 1 1 0 Ergtoxin family E1-E2_ATPase PF00122.15 AMD22261.1 - 3.7e-63 212.6 7.3 7.6e-63 211.6 5.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 AMD22261.1 - 1.1e-23 84.7 0.0 2.2e-23 83.8 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AMD22261.1 - 1.2e-14 54.9 0.0 2.7e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 AMD22261.1 - 1.1e-11 43.9 0.0 3.1e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 AMD22261.1 - 0.0065 16.0 0.1 0.016 14.8 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 AMD22261.1 - 0.022 14.6 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit Zn_clus PF00172.13 AMD22262.1 - 1.2e-06 28.2 10.2 2.9e-06 27.0 7.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BAF1_ABF1 PF04684.8 AMD22262.1 - 0.0068 15.3 17.3 0.011 14.6 12.0 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor Suf PF05843.9 AMD22262.1 - 0.039 13.6 6.6 0.08 12.6 4.5 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4175 PF13779.1 AMD22262.1 - 1.1 6.8 25.0 1.7 6.2 17.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Macoilin PF09726.4 AMD22262.1 - 4 5.6 14.5 8.5 4.5 10.0 1.5 1 0 0 1 1 1 0 Transmembrane protein PAT1 PF09770.4 AMD22262.1 - 4.1 5.5 29.3 6.3 4.9 20.3 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UDPGP PF01704.13 AMD22263.1 - 4.5e-189 628.3 0.0 5.5e-189 628.0 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.1 AMD22263.1 - 0.017 13.7 0.1 0.14 10.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4301) zf-RING_2 PF13639.1 AMD22264.1 - 5e-11 42.2 4.8 1.2e-10 41.0 3.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 AMD22264.1 - 1.1e-08 35.0 4.3 2.6e-08 33.8 3.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 AMD22264.1 - 1.9e-07 30.7 3.8 3.1e-07 30.0 2.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 AMD22264.1 - 7e-07 28.8 3.1 1.4e-06 27.8 2.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD22264.1 - 2.1e-06 27.3 6.6 3.9e-06 26.4 4.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD22264.1 - 1.1e-05 25.3 3.6 1.1e-05 25.3 2.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 AMD22264.1 - 0.0015 18.3 1.0 0.0035 17.1 0.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 AMD22264.1 - 0.0021 17.7 1.5 0.0056 16.3 1.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger DUF2921 PF11145.3 AMD22264.1 - 0.043 11.5 0.0 1.6 6.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2921) Baculo_RING PF05883.6 AMD22264.1 - 0.044 13.6 1.2 0.12 12.1 0.8 1.7 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.3 AMD22264.1 - 0.12 12.2 6.4 0.49 10.4 4.5 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 AMD22264.1 - 1.5 8.9 5.9 4.6 7.3 4.1 1.9 1 1 0 1 1 1 0 RING-variant domain HAD_2 PF13419.1 AMD22265.1 - 1e-14 55.1 0.0 1.2e-14 54.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AMD22265.1 - 1.2e-08 35.6 0.0 1.3e-08 35.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 AMD22265.1 - 0.00017 21.4 0.0 0.00045 20.0 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.2 AMD22265.1 - 0.14 12.2 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Pribosyl_synth PF14572.1 AMD22266.1 - 1.3e-41 142.3 3.7 3.4e-35 121.4 2.0 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 AMD22266.1 - 4.1e-39 132.8 0.7 2.4e-38 130.4 0.0 2.2 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 AMD22266.1 - 5e-11 42.3 0.8 1.2e-10 41.2 0.5 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 AMD22266.1 - 0.0019 17.4 0.2 0.0039 16.4 0.2 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase zf-UBP PF02148.14 AMD22267.1 - 3.1e-21 75.2 9.9 3.1e-21 75.2 6.8 2.0 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein BRAP2 PF07576.7 AMD22267.1 - 8.9e-20 70.3 0.0 1.8e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-RING_2 PF13639.1 AMD22267.1 - 1.8e-09 37.2 9.2 1.8e-09 37.2 6.4 2.6 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.1 AMD22267.1 - 2.3e-06 27.2 8.4 2.3e-06 27.2 5.8 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 AMD22267.1 - 4.4e-05 23.4 9.0 4.4e-05 23.4 6.2 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD22267.1 - 0.00026 20.5 8.8 0.00026 20.5 6.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD22267.1 - 0.00035 20.1 21.1 0.0007 19.2 4.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 AMD22267.1 - 0.00059 19.8 4.9 0.00059 19.8 3.4 2.6 3 0 0 3 3 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 AMD22267.1 - 0.0032 17.1 2.6 0.0032 17.1 1.8 3.3 1 1 1 2 2 1 1 RING-type zinc-finger zf-Apc11 PF12861.2 AMD22267.1 - 0.0083 15.9 5.0 0.0083 15.9 3.5 2.1 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF3829 PF12889.2 AMD22267.1 - 0.025 13.7 8.8 0.041 13.0 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) DUF1664 PF07889.7 AMD22267.1 - 0.044 13.5 7.2 0.11 12.3 5.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CorA PF01544.13 AMD22267.1 - 0.044 12.8 11.4 0.064 12.2 7.9 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein NPV_P10 PF05531.7 AMD22267.1 - 0.31 11.3 6.0 0.65 10.2 0.3 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.7 AMD22267.1 - 0.39 10.5 8.5 1.5 8.6 5.9 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1528 PF07515.6 AMD22267.1 - 0.42 10.6 5.4 0.38 10.8 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1528) DUF4482 PF14818.1 AMD22267.1 - 0.82 10.3 13.9 1.8 9.2 5.8 2.6 2 1 1 3 3 2 0 Domain of unknown function (DUF4482) Phasin PF05597.6 AMD22267.1 - 1.7 8.4 10.1 0.52 10.0 4.8 1.7 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Lzipper-MIP1 PF14389.1 AMD22267.1 - 2.1 8.5 13.7 1.1 9.4 2.8 3.0 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 zf-RING_4 PF14570.1 AMD22267.1 - 2.8 7.6 15.4 0.019 14.5 4.7 1.9 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain DUF4200 PF13863.1 AMD22267.1 - 4.1 7.3 19.2 7.2 6.5 13.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Laminin_II PF06009.7 AMD22267.1 - 7.6 6.3 10.9 3.9 7.2 4.5 2.1 1 1 1 2 2 2 0 Laminin Domain II zf-RING_6 PF14835.1 AMD22267.1 - 8.1 6.3 12.8 0.21 11.4 3.4 2.4 2 1 0 3 3 2 0 zf-RING of BARD1-type protein CDC45 PF02724.9 AMD22268.1 - 0.0033 15.5 0.6 0.0052 14.8 0.4 1.2 1 0 0 1 1 1 1 CDC45-like protein Cnd1 PF12717.2 AMD22268.1 - 0.018 14.9 1.7 0.056 13.2 0.1 2.7 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Form_Nir_trans PF01226.12 AMD22269.1 - 1e-64 217.8 24.4 1.3e-64 217.5 16.9 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter DUF3592 PF12158.3 AMD22269.1 - 0.016 15.0 0.0 6.6 6.5 0.5 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3592) YrhK PF14145.1 AMD22269.1 - 1.7 8.3 8.9 1.4 8.5 0.6 2.8 1 1 1 2 2 2 0 YrhK-like protein HEAT_2 PF13646.1 AMD22270.1 - 0.00045 20.4 0.0 0.026 14.8 0.0 3.4 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.17 AMD22270.1 - 0.00048 19.9 0.3 11 6.3 0.0 4.9 4 0 0 4 4 4 1 HEAT repeat PHD PF00628.24 AMD22271.1 - 4e-16 58.4 22.0 1.8e-10 40.3 6.0 3.0 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.1 AMD22271.1 - 0.0026 17.0 10.4 0.11 11.8 0.2 3.5 3 0 0 3 3 3 2 PHD-finger zf-PHD-like PF15446.1 AMD22271.1 - 0.61 9.3 10.6 0.74 9.0 0.5 2.9 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.1 AMD22271.1 - 1.5 8.6 14.6 0.78 9.5 3.1 3.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.17 AMD22271.1 - 4.2 7.1 18.9 0.6 9.8 1.3 2.9 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) dsDNA_bind PF01984.15 AMD22272.1 - 1.4e-24 86.0 4.1 2.8e-24 85.1 2.8 1.4 1 1 0 1 1 1 1 Double-stranded DNA-binding domain Sigma70_r2 PF04542.9 AMD22272.1 - 0.093 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-70 region 2 Cyt-b5 PF00173.23 AMD22273.1 - 4.1e-16 58.5 0.0 6.4e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HMG_box PF00505.14 AMD22274.1 - 2.9e-32 110.7 13.8 2.1e-18 66.3 4.2 2.8 3 0 0 3 3 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 AMD22274.1 - 1.3e-18 67.0 10.4 6.5e-12 45.6 3.5 3.4 3 0 0 3 3 2 2 HMG-box domain CHDNT PF08073.7 AMD22274.1 - 0.00012 21.6 0.0 0.26 11.0 0.0 2.4 2 0 0 2 2 2 2 CHDNT (NUC034) domain Serinc PF03348.10 AMD22274.1 - 0.032 12.9 7.7 0.046 12.4 5.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) zf-DHHC PF01529.15 AMD22274.1 - 0.7 9.2 3.2 1.6 8.1 2.2 1.6 1 0 0 1 1 1 0 DHHC palmitoyltransferase YjgP_YjgQ PF03739.9 AMD22274.1 - 1.7 7.3 3.8 2.3 6.8 2.6 1.2 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family OATP PF03137.15 AMD22274.1 - 1.7 6.5 4.6 2.5 6.0 3.2 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family FLO_LFY PF01698.11 AMD22274.1 - 2.6 6.7 10.9 5.2 5.8 7.6 1.4 1 0 0 1 1 1 0 Floricaula / Leafy protein Hid1 PF12722.2 AMD22274.1 - 6 4.4 10.9 8.8 3.8 7.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4557 PF15101.1 AMD22274.1 - 7.9 6.2 18.7 18 5.0 13.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) FimP PF09766.4 AMD22274.1 - 9.1 5.2 24.4 17 4.3 16.9 1.4 1 0 0 1 1 1 0 Fms-interacting protein zinc_ribbon_6 PF14599.1 AMD22275.1 - 3.7e-22 77.8 2.8 3.7e-22 77.8 1.9 3.9 4 1 1 5 5 5 1 Zinc-ribbon zf-CHY PF05495.7 AMD22275.1 - 4.4e-13 49.1 17.0 4.4e-13 49.1 11.8 4.3 1 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.1 AMD22275.1 - 1.5e-05 24.7 11.0 1.5e-05 24.7 7.6 5.5 2 1 3 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.1 AMD22275.1 - 0.00041 20.3 8.1 0.00041 20.3 5.6 5.3 3 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD22275.1 - 0.0007 19.2 11.4 0.0007 19.2 7.9 6.1 3 3 2 5 5 5 1 zinc-RING finger domain Cg6151-P PF10233.4 AMD22276.1 - 2.6e-37 127.2 10.7 3.2e-37 126.9 7.4 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF3270 PF11674.3 AMD22276.1 - 7.9 6.5 13.7 1.8 8.6 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) zf-C2H2 PF00096.21 AMD22277.1 - 0.00041 20.5 6.3 0.00041 20.5 4.4 3.6 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22277.1 - 0.003 17.7 5.3 0.003 17.7 3.7 4.3 4 1 0 4 4 4 2 C2H2-type zinc finger Acetyltransf_1 PF00583.19 AMD22278.1 - 4.2e-09 36.3 0.0 7.5e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AMD22278.1 - 0.0011 19.1 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NIF PF03031.13 AMD22279.1 - 1.7e-51 174.0 0.0 2.4e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MFS_1 PF07690.11 AMD22280.1 - 2.7e-35 121.7 22.9 4.3e-35 121.0 15.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 AMD22280.1 - 8.3e-17 60.8 24.5 6.2e-14 51.4 5.0 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.8 AMD22280.1 - 0.0011 17.2 5.0 0.0019 16.4 3.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Malic_M PF03949.10 AMD22281.1 - 1.1e-74 251.1 0.0 1.6e-74 250.7 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 AMD22281.1 - 3e-61 206.1 0.0 4.9e-61 205.4 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain TFIIE_alpha PF02002.12 AMD22282.1 - 3.3e-28 97.2 0.3 1.1e-27 95.5 0.0 2.1 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.7 AMD22282.1 - 4.5e-08 32.2 1.2 1.5e-07 30.6 0.8 1.9 1 0 0 1 1 1 1 TFIIB zinc-binding ThiF PF00899.16 AMD22283.1 - 7.5e-37 126.1 0.0 1.2e-36 125.4 0.0 1.4 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 AMD22283.1 - 0.0007 19.7 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 AMD22283.1 - 0.0074 16.2 0.0 0.023 14.7 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain ApbA PF02558.11 AMD22283.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.1 AMD22283.1 - 0.13 12.5 0.0 0.38 11.0 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding Saccharop_dh PF03435.13 AMD22283.1 - 0.17 10.7 0.3 0.37 9.7 0.2 1.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase Mito_carr PF00153.22 AMD22284.1 - 1.2e-58 194.8 1.9 1.1e-20 73.1 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF2370 PF10176.4 AMD22285.1 - 2.3e-76 256.2 0.0 2.9e-76 255.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Mito_carr PF00153.22 AMD22286.1 - 3.1e-65 215.9 3.1 2.3e-26 91.2 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein GNVR PF13807.1 AMD22286.1 - 0.092 12.5 0.1 0.23 11.2 0.1 1.6 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase SNF5 PF04855.7 AMD22287.1 - 9.7e-65 218.4 1.4 9.7e-65 218.4 1.0 3.8 3 2 0 3 3 3 1 SNF5 / SMARCB1 / INI1 Adap_comp_sub PF00928.16 AMD22288.1 - 6.4e-42 143.4 0.0 8.3e-42 143.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 AMD22288.1 - 6.4e-05 22.6 0.1 0.00011 21.9 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain adh_short PF00106.20 AMD22289.1 - 3e-65 219.1 9.8 9.5e-33 113.4 0.7 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 AMD22289.1 - 9.5e-30 103.5 5.0 1.2e-15 57.6 0.2 2.3 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.14 AMD22289.1 - 1.5e-24 85.7 0.0 3.1e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain adh_short_C2 PF13561.1 AMD22289.1 - 3.8e-19 69.4 1.0 2.9e-09 37.0 0.1 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydrat_N PF13452.1 AMD22289.1 - 5e-07 29.5 0.0 1.6e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase DUF1776 PF08643.5 AMD22289.1 - 0.035 13.2 0.0 0.067 12.3 0.0 1.4 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 3HCDH_N PF02737.13 AMD22289.1 - 1.6 8.3 5.6 3.7 7.1 0.2 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.19 AMD22289.1 - 5.9 5.6 7.1 0.78 8.5 1.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase QCR10 PF09796.4 AMD22290.1 - 3.1e-26 90.7 0.1 3.6e-26 90.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.5 AMD22290.1 - 8.9e-05 22.1 0.1 0.00014 21.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Reo_sigmaC PF04582.7 AMD22291.1 - 0.85 8.7 9.5 0.87 8.7 0.3 2.8 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF1664 PF07889.7 AMD22291.1 - 1.2 8.9 21.6 2 8.2 1.2 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) ERM PF00769.14 AMD22291.1 - 1.5 8.2 46.8 0.083 12.4 2.6 3.6 2 1 1 3 3 3 0 Ezrin/radixin/moesin family COG2 PF06148.6 AMD22291.1 - 2.4 8.0 25.4 3.1 7.6 0.6 3.8 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin-6_N PF09177.6 AMD22291.1 - 8.5 6.8 27.5 1.6 9.1 2.8 5.1 3 1 0 3 3 3 0 Syntaxin 6, N-terminal RXT2_N PF08595.6 AMD22292.1 - 0.0018 18.0 5.8 0.0036 17.1 4.0 1.5 1 0 0 1 1 1 1 RXT2-like, N-terminal TFIIA PF03153.8 AMD22292.1 - 0.011 15.6 7.8 0.013 15.4 5.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Daxx PF03344.10 AMD22292.1 - 0.014 13.9 6.0 0.018 13.5 4.1 1.2 1 0 0 1 1 1 0 Daxx Family FAM176 PF14851.1 AMD22292.1 - 0.081 12.6 4.8 0.19 11.4 3.3 1.7 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.7 AMD22292.1 - 0.086 10.7 12.9 0.11 10.4 8.9 1.1 1 0 0 1 1 1 0 Nop14-like family Nucleo_P87 PF07267.6 AMD22292.1 - 0.11 11.1 7.9 0.16 10.5 5.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SDA1 PF05285.7 AMD22292.1 - 0.58 9.3 10.9 0.84 8.8 7.5 1.2 1 0 0 1 1 1 0 SDA1 PBP1_TM PF14812.1 AMD22292.1 - 1.6 9.0 20.8 3.6 7.9 14.4 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BUD22 PF09073.5 AMD22292.1 - 4.3 6.2 11.9 6.4 5.7 8.3 1.2 1 0 0 1 1 1 0 BUD22 AAA_33 PF13671.1 AMD22293.1 - 2e-05 24.4 0.0 0.038 13.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 AMD22293.1 - 5e-05 23.6 0.0 0.00032 20.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain PRK PF00485.13 AMD22293.1 - 0.00021 20.9 0.0 0.3 10.6 0.0 2.3 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 AMD22293.1 - 0.00037 21.3 0.1 0.0024 18.6 0.0 2.1 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 AMD22293.1 - 0.0017 17.5 0.0 0.0033 16.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin KTI12 PF08433.5 AMD22293.1 - 0.0041 16.3 0.0 0.0067 15.6 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 NB-ARC PF00931.17 AMD22293.1 - 0.0047 15.8 0.0 0.012 14.5 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain AAA_5 PF07728.9 AMD22293.1 - 0.011 15.4 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 AMD22293.1 - 0.027 14.4 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.16 AMD22293.1 - 0.027 13.6 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MobB PF03205.9 AMD22293.1 - 0.041 13.5 0.0 0.079 12.6 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 AMD22293.1 - 0.046 13.2 0.0 0.098 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.17 AMD22293.1 - 0.049 13.0 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain 6PF2K PF01591.13 AMD22293.1 - 0.055 12.5 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.14 AMD22293.1 - 0.06 12.7 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.18 AMD22293.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.14 AMD22293.1 - 0.08 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.10 AMD22293.1 - 0.082 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.1 AMD22293.1 - 0.095 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_30 PF13604.1 AMD22293.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 AMD22293.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.15 AMD22293.1 - 0.11 11.1 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Viral_helicase1 PF01443.13 AMD22293.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ArgK PF03308.11 AMD22293.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 ArgK protein NACHT PF05729.7 AMD22293.1 - 0.13 11.8 0.0 0.36 10.4 0.0 1.6 2 0 0 2 2 2 0 NACHT domain ETF_alpha PF00766.14 AMD22294.1 - 2.8e-34 116.5 0.1 5e-34 115.7 0.1 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.16 AMD22294.1 - 8.3e-30 103.6 0.0 1.4e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ATP-synt_F PF01990.12 AMD22295.1 - 9.9e-31 105.9 0.4 1.1e-30 105.7 0.3 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF1882 PF08966.6 AMD22295.1 - 0.11 12.4 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) DUF257 PF03192.8 AMD22295.1 - 0.11 11.7 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Pyrococcus protein of unknown function, DUF257 DUF2235 PF09994.4 AMD22295.1 - 0.14 11.4 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) BRCT PF00533.21 AMD22296.1 - 2.6e-13 49.8 0.0 6.5e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 AMD22296.1 - 3e-07 30.1 0.0 5.9e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain fn3 PF00041.16 AMD22296.1 - 0.001 19.1 0.0 0.0028 17.7 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.3 AMD22296.1 - 0.011 15.5 0.1 0.028 14.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3006) Pyridox_oxase_2 PF12766.2 AMD22297.1 - 4.4e-30 103.9 0.0 6.5e-30 103.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase B12D PF06522.6 AMD22298.1 - 2.9e-05 23.6 0.0 3.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Glyco_tran_28_C PF04101.11 AMD22299.1 - 5e-23 81.5 0.0 1.2e-22 80.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 AMD22299.1 - 0.034 13.3 0.0 0.057 12.6 0.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 1 Toxin_36 PF10550.4 AMD22299.1 - 0.12 13.5 0.2 0.31 12.2 0.1 1.7 1 0 0 1 1 1 0 Conantokin-G mollusc-toxin AAA PF00004.24 AMD22300.1 - 9.4e-44 148.8 0.0 1.7e-43 148.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 AMD22300.1 - 5.9e-07 29.2 0.0 5.2e-06 26.2 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 AMD22300.1 - 3.7e-06 26.9 0.0 8.6e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 AMD22300.1 - 4.7e-06 26.7 0.0 0.00031 20.8 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AMD22300.1 - 2.9e-05 24.1 0.0 0.00011 22.2 0.0 1.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 AMD22300.1 - 5.4e-05 24.0 0.2 0.00014 22.6 0.0 1.9 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 AMD22300.1 - 0.00012 21.2 0.0 0.00027 20.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 AMD22300.1 - 0.00013 21.6 0.1 0.00031 20.4 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 AMD22300.1 - 0.00022 20.6 0.0 0.00044 19.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 AMD22300.1 - 0.00063 19.6 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD22300.1 - 0.0011 19.2 0.7 0.019 15.2 0.0 2.8 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.1 AMD22300.1 - 0.0017 18.2 0.0 0.0034 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 AMD22300.1 - 0.0018 18.2 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2072 PF09845.4 AMD22300.1 - 0.0025 17.7 0.2 0.006 16.4 0.2 1.6 1 0 0 1 1 1 1 Zn-ribbon containing protein (DUF2072) Zeta_toxin PF06414.7 AMD22300.1 - 0.003 16.6 0.0 0.0067 15.5 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_3 PF07726.6 AMD22300.1 - 0.0048 16.5 0.0 0.015 14.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 AMD22300.1 - 0.0074 15.4 0.2 0.025 13.7 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 AMD22300.1 - 0.009 14.7 0.0 0.022 13.4 0.0 1.7 1 0 0 1 1 1 1 TIP49 C-terminus PhoH PF02562.11 AMD22300.1 - 0.011 14.9 0.0 0.046 12.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.17 AMD22300.1 - 0.024 14.8 0.0 0.077 13.1 0.0 2.0 1 1 1 2 2 2 0 RNA helicase AAA_25 PF13481.1 AMD22300.1 - 0.024 14.0 0.1 0.098 12.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.21 AMD22300.1 - 0.027 13.9 0.0 0.15 11.4 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_24 PF13479.1 AMD22300.1 - 0.031 13.8 0.0 0.07 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 AMD22300.1 - 0.072 11.9 0.0 0.16 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Parvo_NS1 PF01057.12 AMD22300.1 - 0.084 11.7 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.7 AMD22300.1 - 0.087 12.4 0.0 0.36 10.4 0.0 1.9 1 1 1 2 2 2 0 NACHT domain MIF4G PF02854.14 AMD22301.1 - 9.3e-43 146.0 0.1 1.6e-42 145.3 0.1 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 AMD22301.1 - 1.9e-23 82.1 0.8 8.9e-23 79.9 0.6 2.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 SapB_1 PF05184.10 AMD22301.1 - 0.13 12.1 0.0 0.65 9.8 0.0 2.3 1 0 0 1 1 1 0 Saposin-like type B, region 1 TYW3 PF02676.9 AMD22302.1 - 2.3e-61 206.5 0.0 3.3e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 U1snRNP70_N PF12220.3 AMD22302.1 - 0.49 10.7 4.0 0.97 9.8 2.8 1.4 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Gtr1_RagA PF04670.7 AMD22303.1 - 2.9e-67 226.2 0.7 3.7e-67 225.8 0.5 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 AMD22303.1 - 0.0024 17.1 0.2 0.0087 15.3 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF2118 PF09891.4 AMD22303.1 - 0.034 13.8 0.1 0.11 12.2 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) GTP_cyclohydro2 PF00925.15 AMD22303.1 - 0.053 12.7 0.0 0.095 11.9 0.0 1.4 1 0 0 1 1 1 0 GTP cyclohydrolase II KKLCAg1 PF15204.1 AMD22303.1 - 0.097 12.7 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Kita-kyushu lung cancer antigen 1 ELFV_dehydrog PF00208.16 AMD22304.1 - 1e-61 208.6 0.0 1.8e-61 207.8 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 AMD22304.1 - 4.7e-20 70.7 0.0 2e-13 48.7 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase FAST_1 PF06743.10 AMD22304.1 - 0.0072 16.0 0.1 0.041 13.6 0.1 2.4 2 0 0 2 2 2 1 FAST kinase-like protein, subdomain 1 NPR3 PF03666.8 AMD22305.1 - 1.4e-161 538.0 0.7 4.3e-161 536.4 0.0 1.9 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 RRM_1 PF00076.17 AMD22306.1 - 1.2e-30 104.9 2.9 1.1e-13 50.6 0.1 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22306.1 - 1.2e-19 69.8 0.5 2.8e-07 30.2 0.1 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22306.1 - 2.1e-18 66.0 0.1 5.2e-07 29.5 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 AMD22306.1 - 0.00011 21.9 0.1 1.7 8.5 0.0 3.4 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 AMD22306.1 - 0.0067 16.1 0.0 0.062 13.0 0.0 2.5 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Prothymosin PF03247.9 AMD22306.1 - 0.014 15.5 8.6 0.014 15.5 6.0 2.7 3 0 0 3 3 3 0 Prothymosin/parathymosin family Myc_N PF01056.13 AMD22306.1 - 0.59 9.2 13.4 0.27 10.3 3.3 2.4 2 0 0 2 2 2 0 Myc amino-terminal region AAA_2 PF07724.9 AMD22307.1 - 1.7e-45 155.0 0.1 5e-44 150.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 AMD22307.1 - 6.6e-25 87.8 0.3 2.6e-14 53.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 AMD22307.1 - 1.8e-24 85.4 0.4 6.7e-24 83.6 0.3 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 AMD22307.1 - 4.4e-16 58.8 0.0 1.6e-08 34.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.15 AMD22307.1 - 1.5e-12 47.2 2.0 6.7e-06 25.9 0.1 3.3 2 1 0 2 2 2 2 Clp amino terminal domain Sigma54_activat PF00158.21 AMD22307.1 - 3.8e-12 45.9 0.1 3.8e-08 33.0 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 AMD22307.1 - 1.1e-11 45.0 0.1 0.00096 19.3 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.1 AMD22307.1 - 3e-11 43.6 5.7 0.00044 20.2 0.0 4.5 3 2 1 5 5 4 2 AAA ATPase domain TIP49 PF06068.8 AMD22307.1 - 2.7e-05 23.0 5.4 0.051 12.2 0.0 4.1 4 0 0 4 4 4 2 TIP49 C-terminus Mg_chelatase PF01078.16 AMD22307.1 - 0.00029 20.0 0.0 1.1 8.4 0.0 3.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Arch_ATPase PF01637.13 AMD22307.1 - 0.00085 19.0 3.8 0.96 9.1 0.1 4.3 3 1 1 4 4 4 1 Archaeal ATPase AAA_19 PF13245.1 AMD22307.1 - 0.0011 18.7 0.0 0.51 10.1 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 AMD22307.1 - 0.0012 18.7 0.2 0.077 12.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_3 PF07726.6 AMD22307.1 - 0.0016 18.0 0.0 0.46 10.0 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 AMD22307.1 - 0.0019 17.3 0.5 0.071 12.2 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin NACHT PF05729.7 AMD22307.1 - 0.0023 17.5 0.0 1.3 8.6 0.0 3.0 2 0 0 2 2 2 1 NACHT domain AAA_17 PF13207.1 AMD22307.1 - 0.003 18.3 8.3 0.36 11.6 0.0 4.5 5 1 0 5 5 4 1 AAA domain NTPase_1 PF03266.10 AMD22307.1 - 0.0083 15.8 0.1 3 7.5 0.0 3.5 3 0 0 3 3 3 1 NTPase IstB_IS21 PF01695.12 AMD22307.1 - 0.0097 15.3 0.0 1.2 8.5 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein PEPCK_ATP PF01293.15 AMD22307.1 - 0.014 13.9 0.0 0.026 13.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase Torsin PF06309.6 AMD22307.1 - 0.015 15.1 0.0 0.074 12.9 0.0 2.1 2 0 0 2 2 2 0 Torsin MobB PF03205.9 AMD22307.1 - 0.031 13.9 0.0 4.1 7.1 0.0 2.9 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 AMD22307.1 - 0.048 13.9 3.7 7.4 6.9 0.0 3.7 3 1 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 AMD22307.1 - 0.15 12.2 0.1 13 6.0 0.0 2.9 3 0 0 3 3 2 0 RNA helicase AAA_24 PF13479.1 AMD22307.1 - 0.22 11.1 2.7 4.1 6.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain APG6 PF04111.7 AMD22307.1 - 0.54 9.2 10.6 0.99 8.3 7.4 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Uds1 PF15456.1 AMD22307.1 - 0.57 10.1 15.3 2 8.4 10.6 1.9 1 0 0 1 1 1 0 Up-regulated During Septation ABC_tran PF00005.22 AMD22307.1 - 0.6 10.4 4.4 11 6.2 0.0 3.4 3 0 0 3 3 3 0 ABC transporter Sod_Cu PF00080.15 AMD22308.1 - 3e-16 59.8 0.0 5.1e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Fe-S_biosyn PF01521.15 AMD22309.1 - 1.5e-17 63.5 0.0 2.3e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Peptidase_M24 PF00557.19 AMD22310.1 - 1.2e-38 132.8 0.0 2e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 AMD22310.1 - 1.5e-13 51.3 0.0 6.4e-13 49.3 0.0 2.0 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain DUF367 PF04034.8 AMD22310.1 - 0.029 13.9 0.2 0.067 12.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF367) Cofilin_ADF PF00241.15 AMD22311.1 - 7.9e-09 35.4 0.0 9.5e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S13_N PF08069.7 AMD22312.1 - 4e-27 93.8 0.9 5.4e-27 93.4 0.1 1.6 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 AMD22312.1 - 3.1e-23 81.3 0.1 9.9e-23 79.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S15 WD40 PF00400.27 AMD22315.1 - 1.2e-48 161.3 15.5 2.2e-11 43.1 0.5 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.2 AMD22315.1 - 2e-07 30.5 0.2 4.5e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 AMD22315.1 - 3.4e-07 29.7 0.5 3.4e-07 29.7 0.3 2.4 2 1 1 3 3 3 1 F-box domain PRANC PF09372.5 AMD22315.1 - 9.3e-05 22.3 0.1 9.3e-05 22.3 0.1 2.8 3 0 0 3 3 3 1 PRANC domain Nup160 PF11715.3 AMD22315.1 - 0.0031 15.7 6.1 0.52 8.3 0.0 4.6 3 2 1 5 5 5 2 Nucleoporin Nup120/160 CNH PF00780.17 AMD22315.1 - 0.024 14.0 0.0 0.081 12.3 0.0 1.8 1 1 0 1 1 1 0 CNH domain GtrA PF04138.9 AMD22316.1 - 0.041 13.8 0.5 0.06 13.3 0.4 1.2 1 0 0 1 1 1 0 GtrA-like protein 7TM_GPCR_Srsx PF10320.4 AMD22316.1 - 0.068 12.3 4.1 0.096 11.8 2.7 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx SieB PF14163.1 AMD22316.1 - 1.6 8.2 4.5 8.5 5.9 0.4 2.0 1 1 0 2 2 2 0 Superinfection exclusion protein B SMC_N PF02463.14 AMD22317.1 - 1e-58 198.1 26.2 3e-58 196.6 18.2 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 AMD22317.1 - 6.7e-26 90.6 0.0 2e-25 89.1 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 AMD22317.1 - 9.7e-10 38.8 14.5 5.2e-07 29.9 1.2 4.6 2 2 1 4 4 4 2 AAA domain AAA_23 PF13476.1 AMD22317.1 - 1.8e-09 38.2 33.4 1.8e-09 38.2 23.1 6.3 3 2 2 5 5 5 1 AAA domain AAA_29 PF13555.1 AMD22317.1 - 3.4e-08 32.9 0.1 7.7e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 AMD22317.1 - 0.0067 15.6 36.6 0.038 13.1 2.0 5.5 2 2 4 6 6 6 3 Reovirus sigma C capsid protein SbcCD_C PF13558.1 AMD22317.1 - 0.025 14.4 0.0 0.098 12.5 0.0 2.1 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RNA_pol_Rpb2_4 PF04566.8 AMD22317.1 - 0.13 12.0 0.5 1.5 8.7 0.0 2.9 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 4 R_equi_Vir PF05526.6 AMD22317.1 - 0.15 11.7 0.0 0.4 10.3 0.0 1.7 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein AAA_17 PF13207.1 AMD22317.1 - 0.4 11.5 0.0 0.4 11.5 0.0 3.8 3 3 0 3 3 3 0 AAA domain DUF3437 PF11919.3 AMD22318.1 - 3.2e-28 97.2 0.0 1.1e-27 95.5 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) DUF1546 PF07571.8 AMD22318.1 - 0.032 14.3 0.0 0.14 12.2 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1546) Ras PF00071.17 AMD22319.1 - 1.4e-61 206.5 0.6 1.7e-61 206.3 0.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22319.1 - 1.7e-20 73.7 0.1 2.5e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD22319.1 - 9.3e-19 67.3 0.1 1.2e-18 67.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 AMD22319.1 - 2e-08 33.7 0.1 2.3e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 AMD22319.1 - 5e-08 32.5 0.1 3.9e-07 29.7 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD22319.1 - 3e-06 27.1 0.1 5.1e-06 26.4 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 AMD22319.1 - 8.7e-06 25.0 0.1 1.1e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 AMD22319.1 - 0.00026 20.3 0.1 0.0018 17.5 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.24 AMD22319.1 - 0.0041 17.3 0.1 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 AMD22319.1 - 0.0075 15.4 0.1 0.021 14.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 AMD22319.1 - 0.014 15.5 0.0 0.041 14.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.1 AMD22319.1 - 0.021 14.3 0.1 0.063 12.8 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 AMD22319.1 - 0.023 14.7 0.0 0.057 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain MCM PF00493.18 AMD22319.1 - 0.034 12.9 0.0 0.057 12.2 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family DUF815 PF05673.8 AMD22319.1 - 0.037 12.9 0.0 0.13 11.1 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF815) Septin PF00735.13 AMD22319.1 - 0.073 12.0 0.1 0.17 10.8 0.1 1.5 1 0 0 1 1 1 0 Septin ABC_tran PF00005.22 AMD22319.1 - 0.13 12.5 0.3 0.35 11.1 0.2 2.0 1 1 0 1 1 1 0 ABC transporter Peptidase_C48 PF02902.14 AMD22320.1 - 3.8e-34 118.1 0.2 3.8e-34 118.1 0.2 2.0 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain SIR2 PF02146.12 AMD22321.1 - 1.9e-54 184.0 0.0 2.8e-54 183.5 0.0 1.3 1 0 0 1 1 1 1 Sir2 family CRC_subunit PF08624.5 AMD22321.1 - 0.015 15.1 0.0 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Stc1 PF12898.2 AMD22321.1 - 0.025 14.6 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Stc1 domain Paired_CXXCH_1 PF09699.5 AMD22321.1 - 0.14 11.6 1.0 0.27 10.7 0.7 1.5 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) RVT_1 PF00078.22 AMD22322.1 - 6.9e-21 74.5 0.0 1.5e-20 73.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 AMD22322.1 - 4.2e-19 68.8 0.0 1.6e-18 66.9 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain Asp_protease_2 PF13650.1 AMD22322.1 - 3.1e-06 27.5 0.0 7.6e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 AMD22322.1 - 1.8e-05 24.4 1.0 3.5e-05 23.5 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.5 AMD22322.1 - 0.00068 18.9 0.0 0.0039 16.5 0.0 2.2 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger FbpA PF05833.6 AMD22323.1 - 5.3e-30 104.3 22.9 5.3e-30 104.3 15.9 3.4 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3441 PF11923.3 AMD22323.1 - 6.3e-30 103.0 0.4 6.3e-30 103.0 0.3 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 AMD22323.1 - 2.5e-08 33.6 0.0 7.2e-08 32.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Clat_adaptor_s PF01217.15 AMD22324.1 - 1.4e-12 47.5 3.9 2.5e-12 46.6 2.7 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_hydro_81 PF03639.8 AMD22324.1 - 0.027 12.5 0.1 0.035 12.1 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 81 Bromo_TP PF07524.8 AMD22325.1 - 3.5e-07 29.8 0.3 8.7e-07 28.5 0.0 1.8 2 0 0 2 2 2 1 Bromodomain associated NUC173 PF08161.7 AMD22326.1 - 3.1e-71 238.8 0.7 2.8e-69 232.4 0.0 3.6 4 0 0 4 4 4 1 NUC173 domain UME PF08064.8 AMD22326.1 - 0.0025 17.7 4.0 1.4 8.9 0.5 3.9 3 0 0 3 3 3 2 UME (NUC010) domain HEAT PF02985.17 AMD22326.1 - 0.0063 16.4 0.6 6.9 7.0 0.0 4.7 5 0 0 5 5 5 1 HEAT repeat Ribosomal_S16 PF00886.14 AMD22327.1 - 2.1e-18 65.8 0.1 2.8e-18 65.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 Helicase_C_2 PF13307.1 AMD22330.1 - 2.9e-48 163.9 0.0 7.8e-48 162.5 0.0 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.10 AMD22330.1 - 9.8e-47 158.5 2.3 1.6e-46 157.8 1.6 1.3 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.10 AMD22330.1 - 1.5e-06 28.1 0.3 0.0052 16.6 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit PhoH PF02562.11 AMD22330.1 - 0.0016 17.7 0.1 0.35 10.0 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein DEAD PF00270.24 AMD22330.1 - 0.004 16.6 0.0 0.015 14.8 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 AMD22330.1 - 0.0061 16.7 0.1 1.6 8.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain zf-TFIIIC PF12660.2 AMD22331.1 - 1.6e-08 34.3 0.0 3.8e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex WD40 PF00400.27 AMD22331.1 - 0.0012 18.6 0.2 0.24 11.3 0.0 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat PD40 PF07676.7 AMD22331.1 - 0.12 12.0 0.5 22 4.8 0.0 3.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Patched PF02460.13 AMD22332.1 - 1.3e-45 155.6 36.6 5.7e-42 143.6 25.4 3.3 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.3 AMD22332.1 - 4.9e-38 129.9 12.0 4.9e-38 129.9 8.3 2.8 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 AMD22332.1 - 0.00014 20.6 4.3 0.00014 20.6 3.0 2.5 2 0 0 2 2 2 1 MMPL family PPR_2 PF13041.1 AMD22333.1 - 1.3e-11 44.3 11.1 3.5e-06 26.8 0.5 4.1 4 1 1 5 5 5 3 PPR repeat family PPR_3 PF13812.1 AMD22333.1 - 2.4e-06 27.3 0.3 0.92 9.9 0.0 4.8 4 0 0 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.15 AMD22333.1 - 0.29 11.1 6.4 0.95 9.5 0.1 4.2 4 0 0 4 4 4 0 PPR repeat Pil1 PF13805.1 AMD22334.1 - 2.2e-151 502.5 0.6 2.5e-151 502.3 0.4 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.5 AMD22334.1 - 0.017 14.9 1.1 0.14 12.0 0.2 2.7 3 0 0 3 3 3 0 Proto-chlorophyllide reductase 57 kD subunit DEAD PF00270.24 AMD22336.1 - 2.4e-37 128.0 0.0 6.3e-37 126.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22336.1 - 7e-21 73.8 0.2 9.4e-20 70.2 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 AMD22336.1 - 1.4e-14 53.3 0.1 2.9e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 AMD22336.1 - 0.0005 19.9 1.8 0.00064 19.5 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.16 AMD22336.1 - 0.012 14.8 4.3 0.079 12.2 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain PseudoU_synth_1 PF01416.15 AMD22337.1 - 1.1e-28 99.6 0.0 1.2e-18 67.4 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase EAP30 PF04157.11 AMD22338.1 - 1.9e-45 154.7 0.0 2e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family DUF842 PF05811.8 AMD22338.1 - 0.066 12.6 0.6 2.2 7.7 0.1 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Hat1_N PF10394.4 AMD22339.1 - 8.2e-37 126.7 0.8 2e-36 125.4 0.6 1.7 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_7 PF13508.1 AMD22339.1 - 0.007 16.5 0.0 0.025 14.7 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain ScpA_ScpB PF02616.9 AMD22340.1 - 7.2 6.1 15.6 6.4 6.2 1.8 2.2 2 0 0 2 2 2 0 ScpA/B protein MmgE_PrpD PF03972.9 AMD22341.1 - 1e-134 449.1 0.0 1.1e-134 448.9 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Nic96 PF04097.9 AMD22342.1 - 1.5e-220 733.4 12.3 2e-220 733.0 8.5 1.2 1 0 0 1 1 1 1 Nup93/Nic96 XET_C PF06955.7 AMD22342.1 - 0.15 11.8 0.0 0.45 10.2 0.0 1.8 1 0 0 1 1 1 0 Xyloglucan endo-transglycosylase (XET) C-terminus PPI_Ypi1 PF07491.6 AMD22343.1 - 1.4e-20 72.6 18.3 1e-19 69.9 12.7 2.2 1 1 0 1 1 1 1 Protein phosphatase inhibitor CDC45 PF02724.9 AMD22343.1 - 0.4 8.6 15.2 0.45 8.4 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2220 PF09983.4 AMD22343.1 - 2.7 7.0 5.8 5.2 6.1 4.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) JAB PF01398.16 AMD22344.1 - 6.3e-33 112.9 1.1 7.1e-33 112.7 0.1 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 AMD22344.1 - 3.5e-25 88.3 4.6 8.5e-25 87.0 3.2 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 AMD22344.1 - 1.3e-08 34.3 0.0 2.2e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 AMD22344.1 - 0.17 11.3 3.0 2.3 7.6 2.1 2.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0172) UCH PF00443.24 AMD22345.1 - 2.4e-13 49.8 7.1 1.1e-12 47.6 4.9 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 AMD22345.1 - 1.4e-08 34.6 0.0 2.8e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 AMD22345.1 - 3.1 7.1 9.6 0.53 9.6 2.1 2.1 1 1 1 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Peptidase_M24 PF00557.19 AMD22346.1 - 7.2e-57 192.3 0.0 9.5e-57 191.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 AMD22346.1 - 1.4e-24 86.0 0.0 3.8e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain RVT_1 PF00078.22 AMD22347.1 - 5.7e-21 74.8 0.0 1.2e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 AMD22347.1 - 3e-19 69.2 0.0 1.3e-18 67.2 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain Asp_protease_2 PF13650.1 AMD22347.1 - 2.6e-06 27.8 0.0 6.5e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 AMD22347.1 - 1.5e-05 24.6 1.0 3e-05 23.7 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-H2C2 PF09337.5 AMD22347.1 - 0.00054 19.3 0.0 0.0034 16.7 0.0 2.2 2 0 0 2 2 2 1 His(2)-Cys(2) zinc finger CSTF2_hinge PF14327.1 AMD22348.1 - 1e-22 79.9 4.1 1e-21 76.8 2.7 2.7 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.1 AMD22348.1 - 6.3e-05 22.1 1.8 0.00032 19.9 1.0 2.3 1 1 1 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.17 AMD22348.1 - 0.11 12.1 0.0 0.28 10.8 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22348.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PAT1 PF09770.4 AMD22348.1 - 0.15 10.2 24.1 0.2 9.8 16.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RRM_1 PF00076.17 AMD22349.1 - 5.5e-19 67.5 0.0 1.2e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22349.1 - 2.6e-14 52.9 0.0 6.6e-14 51.6 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22349.1 - 3.6e-10 39.5 0.0 7.5e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.1 AMD22349.1 - 1e-08 34.3 0.2 2.3e-08 33.1 0.2 1.6 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.1 AMD22349.1 - 6.1e-06 26.2 0.8 6.1e-06 26.2 0.5 1.6 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 DUF4332 PF14229.1 AMD22349.1 - 0.12 12.3 0.3 0.21 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) TFIIS_M PF07500.9 AMD22350.1 - 5.8e-30 103.7 1.0 5.8e-30 103.7 0.7 2.2 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 AMD22350.1 - 3.1e-17 61.9 6.3 5e-17 61.2 4.4 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 AMD22350.1 - 8.1e-15 54.0 3.0 8.1e-15 54.0 2.1 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Phyto_Pns9_10 PF05878.6 AMD22350.1 - 0.013 14.4 6.4 0.019 13.9 4.4 1.2 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 DUF3752 PF12572.3 AMD22350.1 - 0.014 15.4 3.0 0.034 14.2 2.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) DUF1104 PF06518.6 AMD22350.1 - 0.059 13.5 2.9 2.1 8.5 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) DUF755 PF05501.6 AMD22350.1 - 0.19 11.8 9.8 0.59 10.1 6.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF755) ComZ PF10815.3 AMD22351.1 - 0.13 12.0 0.1 0.36 10.6 0.0 1.8 2 0 0 2 2 2 0 ComZ PALP PF00291.20 AMD22352.1 - 2.9e-58 197.5 0.0 3.7e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 AMD22352.1 - 1.3e-16 60.0 0.2 1.3e-12 47.2 0.1 2.5 2 0 0 2 2 2 2 CBS domain Snf7 PF03357.16 AMD22353.1 - 1.5e-33 115.5 8.1 1.8e-33 115.3 5.6 1.1 1 0 0 1 1 1 1 Snf7 Effector_1 PF04518.7 AMD22353.1 - 0.2 10.6 6.5 0.24 10.3 2.9 1.9 1 1 1 2 2 2 0 Effector from type III secretion system DNA_topoisoIV PF00521.15 AMD22353.1 - 0.69 8.6 8.2 1.4 7.7 5.7 1.4 1 1 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Nsp1_C PF05064.8 AMD22353.1 - 1.7 8.3 10.8 0.73 9.4 2.4 2.9 1 1 2 3 3 3 0 Nsp1-like C-terminal region ALAD PF00490.16 AMD22354.1 - 3.3e-112 374.5 0.0 4.1e-112 374.2 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase PITH PF06201.8 AMD22355.1 - 1.4e-42 145.0 0.1 1.8e-42 144.6 0.1 1.1 1 0 0 1 1 1 1 PITH domain YycI PF09648.5 AMD22356.1 - 0.077 12.4 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 YycH protein YqzH PF14164.1 AMD22357.1 - 0.12 12.3 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 YqzH-like protein P12 PF12669.2 AMD22358.1 - 4.9 7.4 3.7 12 6.2 2.6 1.6 1 1 0 1 1 1 0 Virus attachment protein p12 family PWI PF01480.12 AMD22359.1 - 0.006 16.6 3.1 0.0088 16.1 0.2 2.6 3 0 0 3 3 3 1 PWI domain PALP PF00291.20 AMD22360.1 - 2.8e-61 207.4 0.0 3.3e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AlaDh_PNT_C PF01262.16 AMD22360.1 - 0.0044 16.5 0.0 0.026 14.0 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain CTP_transf_2 PF01467.21 AMD22361.1 - 2.9e-35 121.6 0.0 4e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase UCH PF00443.24 AMD22362.1 - 6.1e-44 150.1 0.1 6.1e-44 150.1 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD22362.1 - 1.1e-22 80.8 1.4 4.6e-22 78.8 0.0 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 AMD22362.1 - 5.9e-21 74.3 5.3 5.9e-21 74.3 3.7 3.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 AMD22362.1 - 1.1e-14 53.6 0.1 2.1e-08 33.7 0.0 3.2 3 0 0 3 3 3 2 UBA/TS-N domain ECH PF00378.15 AMD22363.1 - 3.6e-30 104.8 0.0 1.9e-29 102.4 0.0 1.9 1 1 2 3 3 3 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 AMD22363.1 - 2.8e-18 66.1 0.3 6.5e-18 64.9 0.2 1.6 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region DUF3317 PF11779.3 AMD22364.1 - 0.44 10.0 6.9 0.75 9.2 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) Pkinase PF00069.20 AMD22365.1 - 3.8e-37 127.8 0.9 5.1e-37 127.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22365.1 - 1.7e-28 99.4 0.0 2.8e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD22365.1 - 0.0075 15.2 0.0 0.017 14.0 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 AMD22365.1 - 0.091 12.4 0.0 0.51 10.0 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family ORC2 PF04084.9 AMD22366.1 - 1e-100 336.8 0.7 1.3e-100 336.4 0.5 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 AT_hook PF02178.14 AMD22366.1 - 0.1 12.3 4.7 0.23 11.2 3.3 1.6 1 0 0 1 1 1 0 AT hook motif TFIIS_C PF01096.13 AMD22367.1 - 1.9e-22 78.5 1.2 1.9e-22 78.5 0.8 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 AMD22367.1 - 2.8e-10 39.7 4.4 3.6e-10 39.3 0.8 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit DZR PF12773.2 AMD22367.1 - 0.002 17.9 5.3 0.034 13.9 0.2 2.4 2 1 0 2 2 2 1 Double zinc ribbon Terminase_GpA PF05876.7 AMD22367.1 - 0.017 13.5 1.1 0.5 8.6 0.7 2.0 1 1 0 1 1 1 0 Phage terminase large subunit (GpA) Elf1 PF05129.8 AMD22367.1 - 0.028 14.1 0.9 1 9.0 0.0 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.1 AMD22367.1 - 0.038 14.2 5.0 0.26 11.6 0.5 2.5 1 1 1 2 2 2 0 Restriction alleviation protein Lar Baculo_LEF5_C PF11792.3 AMD22367.1 - 0.092 12.1 0.8 0.44 9.9 0.0 2.2 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain C1_4 PF07975.7 AMD22367.1 - 0.11 12.4 3.4 2.4 8.2 0.1 2.5 2 1 0 2 2 2 0 TFIIH C1-like domain Zn_Tnp_IS1595 PF12760.2 AMD22367.1 - 0.21 11.4 0.3 0.21 11.4 0.2 2.9 2 1 1 3 3 3 0 Transposase zinc-ribbon domain Desulfoferrod_N PF06397.7 AMD22367.1 - 0.25 10.7 1.7 0.31 10.4 0.1 1.9 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain IBR PF01485.16 AMD22367.1 - 0.53 10.1 8.7 0.27 11.1 0.3 2.8 2 1 0 2 2 2 0 IBR domain zf-CHY PF05495.7 AMD22367.1 - 3.5 7.8 5.3 2 8.5 0.1 2.3 2 1 0 2 2 2 0 CHY zinc finger zf-RING_3 PF14369.1 AMD22367.1 - 7.1 6.7 12.0 1.2e+02 2.8 4.3 3.8 3 1 0 3 3 3 0 zinc-finger Coprogen_oxidas PF01218.13 AMD22368.1 - 3.4e-130 432.9 0.0 3.9e-130 432.7 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase zf-H2C2_2 PF13465.1 AMD22369.1 - 8.5e-06 25.8 16.0 4.2e-05 23.6 2.4 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 AMD22369.1 - 0.0038 17.4 4.7 0.0038 17.4 3.3 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22369.1 - 0.0086 16.3 17.6 0.32 11.4 4.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger FYVE PF01363.16 AMD22369.1 - 0.6 10.0 14.9 3.6 7.5 10.3 2.1 1 1 0 1 1 1 0 FYVE zinc finger DUF2296 PF10058.4 AMD22370.1 - 0.007 16.0 5.8 5.2 6.9 2.2 3.7 3 0 0 3 3 3 3 Predicted integral membrane metal-binding protein (DUF2296) TP2 PF01254.13 AMD22370.1 - 1.3 9.3 11.4 1.6 9.0 2.2 2.3 2 0 0 2 2 2 0 Nuclear transition protein 2 zf-RING_2 PF13639.1 AMD22372.1 - 1.1e-10 41.1 10.8 1.7e-10 40.5 7.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 AMD22372.1 - 1.4e-08 34.7 9.8 1.8e-08 34.3 6.2 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 AMD22372.1 - 1.5e-05 24.7 7.8 3.4e-05 23.5 5.2 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 AMD22372.1 - 0.0003 20.3 11.3 0.00047 19.7 7.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD22372.1 - 0.00036 20.4 12.6 0.00059 19.8 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD22372.1 - 0.00068 19.2 9.1 0.0012 18.5 6.3 1.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD22372.1 - 0.0054 16.4 8.5 0.0081 15.8 5.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 AMD22372.1 - 0.24 11.1 6.6 0.45 10.2 4.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.3 AMD22372.1 - 0.31 10.5 5.2 0.55 9.7 3.6 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.1 AMD22372.1 - 0.36 10.7 10.4 0.88 9.4 7.2 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.3 AMD22372.1 - 0.39 10.6 8.3 3.6 7.6 5.7 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-P11 PF03854.9 AMD22372.1 - 4.8 6.7 10.5 10 5.6 6.2 2.0 1 1 1 2 2 2 0 P-11 zinc finger Ribosomal_S10 PF00338.17 AMD22373.1 - 3.8e-27 93.9 0.0 8.4e-27 92.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e FtsJ PF01728.14 AMD22374.1 - 2.2e-64 216.8 0.0 2.7e-64 216.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 AMD22374.1 - 0.13 11.8 0.0 0.8 9.2 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 AMD22374.1 - 0.14 12.7 0.0 0.66 10.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain tRNA-synt_2 PF00152.15 AMD22375.1 - 1.3e-88 297.0 0.7 1.3e-88 297.0 0.5 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AMD22375.1 - 2.6e-11 43.2 0.3 1.4e-10 40.8 0.1 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 AMD22375.1 - 3.2e-08 33.0 0.0 0.00028 20.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 AMD22375.1 - 0.028 13.9 0.5 1.3 8.5 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) AA_permease PF00324.16 AMD22376.1 - 2.6e-112 375.6 40.7 3e-112 375.4 28.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD22376.1 - 1.1e-32 113.1 40.9 1.4e-32 112.7 28.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AMD22377.1 - 3.6e-118 394.9 27.0 4.6e-118 394.5 18.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD22377.1 - 2.9e-30 105.1 28.4 3.6e-30 104.8 19.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AMD22378.1 - 1.3e-128 429.3 43.3 1.5e-128 429.1 30.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 AMD22378.1 - 9.1e-36 123.2 44.6 1.1e-35 123.0 30.9 1.1 1 0 0 1 1 1 1 Amino acid permease Trp_oprn_chp PF09534.5 AMD22378.1 - 0.076 12.6 2.0 0.16 11.5 0.1 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Spore_permease PF03845.8 AMD22378.1 - 5.3 5.5 32.9 1.6 7.2 12.9 3.5 3 1 0 3 3 3 0 Spore germination protein TIM PF00121.13 AMD22380.1 - 7.4e-91 303.5 0.3 8.4e-91 303.3 0.2 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase MreB_Mbl PF06723.8 AMD22380.1 - 0.023 13.3 0.1 0.29 9.6 0.0 2.4 2 1 1 3 3 3 0 MreB/Mbl protein Alg14 PF08660.6 AMD22381.1 - 2.5e-47 161.0 0.0 3.4e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like UQ_con PF00179.21 AMD22382.1 - 1.8e-44 150.5 0.0 2.4e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 AMD22382.1 - 0.0037 17.0 0.0 0.012 15.3 0.0 1.8 1 1 0 1 1 1 1 Prokaryotic E2 family B AMNp_N PF10423.4 AMD22382.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Daxx PF03344.10 AMD22382.1 - 5.8 5.2 19.8 6.9 5.0 13.8 1.1 1 0 0 1 1 1 0 Daxx Family NOA36 PF06524.7 AMD22382.1 - 6.8 5.8 17.1 8.8 5.4 11.9 1.1 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.7 AMD22382.1 - 8.5 4.1 24.0 11 3.7 16.7 1.2 1 0 0 1 1 1 0 Nop14-like family Fimbrial_PilY2 PF14481.1 AMD22383.1 - 0.0014 18.0 0.0 0.0023 17.3 0.0 1.3 1 0 0 1 1 1 1 Type 4 fimbrial biogenesis protein PilY2 Dfp1_Him1_M PF08630.5 AMD22384.1 - 2.4e-45 153.3 0.1 9.4e-45 151.4 0.0 2.1 1 1 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.7 AMD22384.1 - 1.1e-20 72.9 0.9 1.1e-20 72.9 0.6 1.8 2 0 0 2 2 2 1 DBF zinc finger Zn_clus PF00172.13 AMD22385.1 - 6.1e-08 32.4 10.0 6.1e-08 32.4 6.9 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.21 AMD22386.1 - 7.2e-12 44.9 7.6 5e-06 26.5 0.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22386.1 - 3e-07 30.2 5.8 0.0007 19.7 0.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD22386.1 - 1.6e-06 28.1 11.2 2.5e-06 27.4 0.3 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 AMD22386.1 - 0.0069 16.5 0.7 0.098 12.8 0.0 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 AMD22386.1 - 0.014 15.2 5.7 0.36 10.7 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.2 AMD22386.1 - 0.063 13.4 1.3 1.8 8.8 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type ADK_lid PF05191.9 AMD22386.1 - 0.25 11.0 3.4 1.6 8.4 0.1 2.5 2 0 0 2 2 2 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.5 AMD22386.1 - 0.26 11.2 2.2 6 6.9 0.3 2.8 1 1 1 2 2 2 0 Zinc ribbon domain Peptidase_M28 PF04389.12 AMD22387.1 - 2.2e-32 112.2 0.2 4.7e-32 111.1 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.23 AMD22387.1 - 1.5e-06 27.8 0.0 1.8e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 AMD22387.1 - 0.00082 18.2 0.0 0.0018 17.1 0.0 1.5 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase URO-D PF01208.12 AMD22388.1 - 1.3e-119 399.1 0.0 1.5e-119 398.9 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ank_5 PF13857.1 AMD22389.1 - 3.2e-05 24.0 0.0 6.9e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 AMD22389.1 - 0.014 15.6 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) zf-C2H2_jaz PF12171.3 AMD22389.1 - 0.091 12.9 0.6 0.41 10.8 0.4 2.1 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ank PF00023.25 AMD22389.1 - 0.15 11.9 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat SNF2_N PF00176.18 AMD22390.1 - 7.2e-62 208.8 0.0 1e-61 208.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD22390.1 - 7.7e-11 41.7 0.0 3.1e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 AMD22390.1 - 2.3e-09 36.4 1.6 2.7e-08 32.9 1.1 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 AMD22390.1 - 5.2e-08 32.5 0.0 1.4e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 AMD22390.1 - 7.3e-08 32.4 0.0 1.8e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2439 PF10382.4 AMD22390.1 - 0.00015 21.8 0.0 0.00053 20.1 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DUF2075 PF09848.4 AMD22390.1 - 0.041 12.8 0.0 0.12 11.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) LemA PF04011.7 AMD22391.1 - 0.056 12.5 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 LemA family Ion_trans_N PF08412.5 AMD22394.1 - 0.054 12.7 0.1 0.055 12.7 0.1 1.1 1 0 0 1 1 1 0 Ion transport protein N-terminal zf-C3HC4_4 PF15227.1 AMD22395.1 - 3.2e-10 39.6 10.4 3.2e-10 39.6 7.2 2.3 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 AMD22395.1 - 3.2e-09 36.3 9.2 3.2e-09 36.3 6.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD22395.1 - 2.1e-08 34.0 9.4 2.1e-08 34.0 6.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD22395.1 - 2.4e-08 33.6 8.7 2.4e-08 33.6 6.1 2.3 2 1 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 AMD22395.1 - 6.9e-07 28.8 1.1 2e-06 27.4 0.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.1 AMD22395.1 - 1.5e-06 27.7 6.5 1.5e-06 27.7 4.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD22395.1 - 3.7e-05 23.3 7.5 3.7e-05 23.3 5.2 2.6 2 0 0 2 2 2 1 zinc-RING finger domain PolC_DP2 PF03833.8 AMD22395.1 - 0.00014 19.7 3.8 0.012 13.2 0.4 2.1 2 0 0 2 2 2 2 DNA polymerase II large subunit DP2 zf-Apc11 PF12861.2 AMD22395.1 - 0.00015 21.5 2.5 0.00015 21.5 1.7 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 AMD22395.1 - 0.00024 21.1 6.3 0.00024 21.1 4.4 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_6 PF14835.1 AMD22395.1 - 0.025 14.3 8.3 0.04 13.7 1.3 2.3 2 0 0 2 2 2 0 zf-RING of BARD1-type protein DZR PF12773.2 AMD22395.1 - 0.094 12.5 11.6 1.4 8.7 0.4 2.9 2 1 1 3 3 3 0 Double zinc ribbon zinc_ribbon_4 PF13717.1 AMD22395.1 - 0.096 12.3 3.3 38 4.0 0.0 3.6 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AMD22395.1 - 0.14 11.7 4.0 29 4.3 0.0 3.6 3 0 0 3 3 3 0 zinc-ribbon domain Zn_ribbon_recom PF13408.1 AMD22395.1 - 0.63 10.3 10.2 8.2 6.7 2.7 3.3 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain CpXC PF14353.1 AMD22395.1 - 6.5 6.7 11.4 12 5.8 0.4 3.3 2 2 1 3 3 3 0 CpXC protein LRR_2 PF07723.8 AMD22397.1 - 4.3 8.0 0.0 4.3 8.0 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich Repeat DUF2428 PF10350.4 AMD22398.1 - 1e-66 224.5 0.1 1.8e-66 223.8 0.0 1.4 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 AMD22398.1 - 7e-06 25.6 0.7 0.22 11.7 0.0 5.1 4 0 0 4 4 4 2 HEAT repeat Mg_trans_NIPA PF05653.9 AMD22399.1 - 1.4e-102 342.6 17.0 1.7e-102 342.4 11.8 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 AMD22399.1 - 8.6e-07 29.1 4.6 8.6e-07 29.1 3.2 3.3 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 AMD22399.1 - 6.7e-06 26.1 6.3 6.7e-06 26.1 4.4 3.3 4 1 0 4 4 4 1 EamA-like transporter family DUF3671 PF12420.3 AMD22399.1 - 5.2 7.0 15.7 0.18 11.8 2.8 2.8 2 1 1 3 3 3 0 Protein of unknown function eIF-1a PF01176.14 AMD22400.1 - 2.7e-27 93.9 0.3 3.9e-27 93.4 0.2 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myb_DNA-bind_6 PF13921.1 AMD22400.1 - 0.047 13.8 0.0 0.081 13.0 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Glyco_transf_20 PF00982.16 AMD22401.1 - 7.8e-160 532.4 0.5 1.9e-159 531.1 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 AMD22401.1 - 1.8e-30 105.5 0.0 3.7e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase TatD_DNase PF01026.16 AMD22402.1 - 3.5e-34 118.1 0.0 4.4e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase SAP30_Sin3_bdg PF13867.1 AMD22403.1 - 5.1e-14 51.8 0.2 5.6e-11 42.1 0.0 2.3 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 CUE PF02845.11 AMD22404.1 - 1.3e-08 34.1 0.1 3.4e-08 32.7 0.0 1.8 2 0 0 2 2 2 1 CUE domain ORC6 PF05460.8 AMD22404.1 - 0.014 14.4 3.2 0.017 14.2 2.2 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) GvpO PF05800.6 AMD22404.1 - 0.085 12.7 0.1 0.42 10.5 0.0 2.2 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpO Shisa PF13908.1 AMD22404.1 - 0.09 12.9 1.9 0.12 12.5 0.1 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator WD40 PF00400.27 AMD22405.1 - 1.2e-29 101.1 4.3 4e-07 29.6 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 AMD22405.1 - 2.2e-06 27.5 0.2 0.0014 18.3 0.0 3.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 AMD22405.1 - 0.00048 19.0 0.9 0.66 8.7 0.3 2.4 2 1 0 2 2 2 2 Coatomer WD associated region BBS2_Mid PF14783.1 AMD22405.1 - 0.0078 15.9 0.1 6.1 6.6 0.0 3.4 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region HIRA_B PF09453.5 AMD22405.1 - 0.037 13.5 0.1 0.087 12.4 0.1 1.6 1 0 0 1 1 1 0 HIRA B motif Apc4_WD40 PF12894.2 AMD22405.1 - 0.068 12.6 0.0 0.72 9.3 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2410 PF10307.4 AMD22406.1 - 2.2e-63 213.2 0.1 3.5e-63 212.5 0.1 1.3 1 0 0 1 1 1 1 Hypothetical protein (DUF2410) DUF221 PF02714.10 AMD22407.1 - 6.9e-97 324.2 23.6 1.5e-96 323.0 16.3 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 AMD22407.1 - 1.4e-32 112.4 1.6 1.4e-32 112.4 1.1 2.9 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 AMD22407.1 - 7.1e-27 93.1 0.0 2.1e-26 91.6 0.0 1.8 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 AMD22407.1 - 7.9e-17 61.5 1.5 1.8e-16 60.4 1.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) XRCC4 PF06632.7 AMD22407.1 - 0.057 12.2 0.2 0.087 11.6 0.1 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Prion_bPrPp PF11587.3 AMD22407.1 - 1.5 8.5 4.4 5.2 6.8 0.2 2.6 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal DUF1700 PF08006.6 AMD22407.1 - 1.8 7.8 16.4 2.8 7.1 3.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Pyrophosphatase PF00719.14 AMD22408.1 - 1.7e-51 173.7 0.0 2.2e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Nup188 PF10487.4 AMD22409.1 - 3.4e-202 673.9 29.1 5.6e-202 673.2 20.1 1.3 1 0 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 RRM_1 PF00076.17 AMD22410.1 - 1.8e-36 123.5 1.0 1.2e-11 44.0 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22410.1 - 1.4e-30 105.0 0.6 2.1e-10 40.4 0.0 4.3 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22410.1 - 3.3e-22 78.0 3.0 1.9e-05 24.3 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 AMD22410.1 - 0.0096 15.6 0.7 0.14 11.9 0.0 3.2 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Lsm_interact PF05391.6 AMD22410.1 - 0.013 14.9 0.5 0.041 13.3 0.3 1.8 1 0 0 1 1 1 0 Lsm interaction motif Nup35_RRM_2 PF14605.1 AMD22410.1 - 0.096 12.4 0.0 6.7 6.5 0.0 2.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif G-patch PF01585.18 AMD22411.1 - 0.0093 15.7 2.8 0.14 11.9 1.9 2.4 1 1 0 1 1 1 1 G-patch domain RR_TM4-6 PF06459.7 AMD22411.1 - 0.44 10.4 8.6 0.5 10.2 5.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.17 AMD22411.1 - 2 7.3 3.8 2.3 7.1 2.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.9 AMD22411.1 - 6 4.7 12.3 7.4 4.4 8.5 1.0 1 0 0 1 1 1 0 CDC45-like protein PXA PF02194.10 AMD22412.1 - 6.8e-38 130.0 2.4 6.8e-38 130.0 1.7 2.6 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.7 AMD22412.1 - 1.8e-27 95.6 3.4 3.2e-27 94.8 0.1 2.7 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.19 AMD22412.1 - 6e-17 61.4 6.7 1.6e-15 56.8 1.8 3.2 2 1 0 2 2 2 2 PX domain RGS PF00615.14 AMD22412.1 - 4.7e-06 26.6 1.5 4.7e-06 26.6 1.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain ASFV_360 PF01671.11 AMD22412.1 - 0.0033 16.8 0.7 0.0088 15.4 0.5 1.6 1 0 0 1 1 1 1 African swine fever virus multigene family 360 protein RRN9 PF10680.4 AMD22413.1 - 7.9e-16 57.5 0.5 1.5e-15 56.6 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor SRP19 PF01922.12 AMD22414.1 - 5e-30 103.9 0.0 9.8e-30 102.9 0.0 1.5 1 0 0 1 1 1 1 SRP19 protein Pribosyltran PF00156.22 AMD22415.1 - 5.8e-16 58.3 0.5 9.9e-16 57.6 0.3 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain zf-C3HC PF07967.8 AMD22416.1 - 4.4e-13 49.1 0.7 1.8e-10 40.7 0.1 2.4 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.5 AMD22416.1 - 0.0012 18.6 0.3 0.0012 18.6 0.2 2.4 2 1 0 2 2 2 1 Rsm1-like SUN PF03856.8 AMD22417.1 - 5.2e-85 284.7 13.2 6.1e-85 284.4 9.2 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Glucosamine_iso PF01182.15 AMD22418.1 - 2.2e-49 167.8 0.0 2.6e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HSF_DNA-bind PF00447.12 AMD22419.1 - 2.6e-24 85.3 0.3 1.1e-23 83.3 0.0 2.1 2 0 0 2 2 2 1 HSF-type DNA-binding RRM_1 PF00076.17 AMD22420.1 - 8.8e-33 111.7 0.1 1.8e-15 56.3 0.0 5.8 5 1 1 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22420.1 - 1.4e-20 73.0 0.0 2.8e-09 36.8 0.0 4.6 5 1 0 5 5 5 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22420.1 - 2.6e-08 33.5 0.2 0.039 13.8 0.0 4.4 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dna2 PF08696.6 AMD22421.1 - 3.2e-60 203.0 1.3 3.2e-60 203.0 0.9 2.0 2 0 0 2 2 2 1 DNA replication factor Dna2 AAA_12 PF13087.1 AMD22421.1 - 1.8e-46 158.0 0.0 3.5e-46 157.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 AMD22421.1 - 4e-36 124.7 0.2 1.4e-17 64.1 0.0 2.8 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.1 AMD22421.1 - 3.1e-13 49.7 0.0 8.2e-13 48.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain PDDEXK_1 PF12705.2 AMD22421.1 - 7.8e-09 35.2 0.0 1.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily AAA_19 PF13245.1 AMD22421.1 - 4.5e-08 32.7 0.0 1.1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 AMD22421.1 - 1.4e-05 24.7 0.6 0.4 10.1 0.1 3.5 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.12 AMD22421.1 - 9.1e-05 22.4 0.1 0.00051 20.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF83 MobB PF03205.9 AMD22421.1 - 0.00028 20.6 0.2 0.00063 19.4 0.2 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 AMD22421.1 - 0.00076 19.5 0.0 0.0021 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain PhoH PF02562.11 AMD22421.1 - 0.0013 17.9 0.0 0.0025 17.0 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein SRP54 PF00448.17 AMD22421.1 - 0.0014 18.1 0.2 0.003 17.0 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.1 AMD22421.1 - 0.0017 18.2 0.1 0.021 14.6 0.0 2.7 3 0 0 3 3 3 1 AAA domain ResIII PF04851.10 AMD22421.1 - 0.0027 17.5 0.7 0.02 14.7 0.1 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 AMD22421.1 - 0.0028 17.2 0.0 0.0096 15.5 0.0 1.9 1 0 0 1 1 1 1 Helicase DUF2075 PF09848.4 AMD22421.1 - 0.003 16.5 0.0 0.0059 15.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.16 AMD22421.1 - 0.0036 16.6 0.0 0.011 15.0 0.0 1.8 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_25 PF13481.1 AMD22421.1 - 0.005 16.2 0.0 0.0097 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 AMD22421.1 - 0.0081 15.8 0.1 0.073 12.7 0.2 2.3 2 0 0 2 2 2 1 NTPase T2SE PF00437.15 AMD22421.1 - 0.012 14.4 0.0 0.024 13.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.9 AMD22421.1 - 0.014 15.0 0.1 0.04 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 AMD22421.1 - 0.029 14.5 0.1 0.081 13.1 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 AMD22421.1 - 0.06 13.4 0.2 0.28 11.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain CbiA PF01656.18 AMD22421.1 - 0.077 12.3 1.6 0.38 10.1 0.9 2.3 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ArgK PF03308.11 AMD22421.1 - 0.087 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 ArgK protein ATP_bind_1 PF03029.12 AMD22421.1 - 0.093 12.2 1.7 0.17 11.3 0.1 2.2 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein IL13 PF03487.8 AMD22421.1 - 0.79 9.4 2.4 13 5.5 0.1 3.5 4 0 0 4 4 4 0 Interleukin-13 PalH PF08733.5 AMD22422.1 - 1.7e-46 158.6 18.5 2.4e-46 158.2 12.9 1.2 1 0 0 1 1 1 1 PalH/RIM21 Cellulase PF00150.13 AMD22423.1 - 2.6e-11 43.2 7.8 4.6e-10 39.1 5.4 2.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) UAA PF08449.6 AMD22425.1 - 3.8e-15 55.5 23.4 4.7e-15 55.2 16.2 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 AMD22425.1 - 9.3e-10 38.3 6.4 9.3e-10 38.3 4.4 3.0 1 1 2 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 AMD22425.1 - 0.0063 16.5 30.3 0.052 13.5 5.0 2.5 2 1 0 2 2 2 2 EamA-like transporter family PHO4 PF01384.15 AMD22425.1 - 0.56 8.8 14.9 0.026 13.2 0.7 2.5 2 1 0 2 2 2 0 Phosphate transporter family Nse5 PF08691.5 AMD22426.1 - 7.1e-23 80.8 7.8 9.1e-23 80.5 5.4 1.1 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 HAD_2 PF13419.1 AMD22427.1 - 4.3e-24 85.6 0.1 5.7e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AMD22427.1 - 0.0059 17.0 0.0 0.083 13.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NifW PF03206.9 AMD22428.1 - 0.011 15.8 0.0 4.3 7.4 0.0 2.6 2 0 0 2 2 2 0 Nitrogen fixation protein NifW Vps51 PF08700.6 AMD22428.1 - 0.033 14.0 0.1 0.2 11.5 0.0 2.3 2 1 0 2 2 2 0 Vps51/Vps67 ABC_tran PF00005.22 AMD22429.1 - 2.5e-48 163.8 0.0 2.8e-23 82.7 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 AMD22429.1 - 2.7e-22 80.1 3.0 2e-06 28.0 0.0 4.3 2 2 1 3 3 3 3 AAA domain ABC_tran_2 PF12848.2 AMD22429.1 - 2.2e-21 75.4 1.6 2.2e-21 75.4 1.1 3.4 3 0 0 3 3 2 1 ABC transporter SMC_N PF02463.14 AMD22429.1 - 1.5e-09 37.3 1.4 0.24 10.5 0.1 4.9 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 AMD22429.1 - 1.1e-08 34.4 0.0 0.0019 17.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 AMD22429.1 - 3e-08 33.8 0.1 0.007 16.4 0.0 3.2 3 1 0 3 3 2 2 AAA domain Miro PF08477.8 AMD22429.1 - 1.4e-07 32.0 0.9 0.0088 16.5 0.0 3.4 3 0 0 3 3 3 2 Miro-like protein AAA_17 PF13207.1 AMD22429.1 - 1.8e-07 31.9 4.4 0.0019 18.9 0.0 3.6 3 2 0 3 3 2 2 AAA domain DUF258 PF03193.11 AMD22429.1 - 2.5e-07 30.0 0.8 0.00024 20.3 0.0 2.7 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_18 PF13238.1 AMD22429.1 - 7.2e-07 29.5 1.9 0.021 15.1 0.0 3.5 4 1 0 4 4 3 2 AAA domain AAA_23 PF13476.1 AMD22429.1 - 1e-06 29.2 13.6 0.0049 17.2 0.0 4.1 4 1 0 4 4 4 2 AAA domain AAA PF00004.24 AMD22429.1 - 7.5e-06 26.1 0.2 0.13 12.4 0.0 3.7 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 AMD22429.1 - 7.5e-06 25.5 0.0 0.039 13.3 0.1 3.2 3 0 0 3 3 3 2 AAA-like domain NACHT PF05729.7 AMD22429.1 - 8.4e-06 25.5 0.7 0.16 11.6 0.0 2.8 3 0 0 3 3 2 2 NACHT domain MMR_HSR1 PF01926.18 AMD22429.1 - 1.3e-05 25.1 0.4 0.039 13.9 0.1 3.4 3 2 0 3 3 3 2 50S ribosome-binding GTPase MobB PF03205.9 AMD22429.1 - 1.4e-05 24.7 0.3 0.00045 19.9 0.2 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 AMD22429.1 - 4e-05 23.6 0.2 0.44 10.5 0.0 3.3 3 1 0 3 3 3 2 AAA ATPase domain RNA_helicase PF00910.17 AMD22429.1 - 4.3e-05 23.6 0.0 0.29 11.3 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.1 AMD22429.1 - 5.1e-05 23.1 0.1 0.57 10.0 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.1 AMD22429.1 - 5.6e-05 23.0 0.2 0.11 12.4 0.0 3.4 4 0 0 4 4 3 1 AAA domain AAA_28 PF13521.1 AMD22429.1 - 0.00013 22.0 0.1 0.61 10.0 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_15 PF13175.1 AMD22429.1 - 0.00031 19.9 1.2 0.86 8.5 0.0 3.7 5 0 0 5 5 4 2 AAA ATPase domain AAA_25 PF13481.1 AMD22429.1 - 0.00043 19.7 0.1 0.6 9.4 0.1 3.4 2 1 0 2 2 2 1 AAA domain VirE PF05272.6 AMD22429.1 - 0.00078 18.9 0.2 0.37 10.2 0.0 3.0 3 0 0 3 3 3 1 Virulence-associated protein E MCM PF00493.18 AMD22429.1 - 0.0008 18.2 1.4 0.19 10.5 0.0 2.9 3 0 0 3 3 3 1 MCM2/3/5 family ArgK PF03308.11 AMD22429.1 - 0.00096 18.0 0.3 0.097 11.4 0.1 2.7 3 0 0 3 3 3 1 ArgK protein Arch_ATPase PF01637.13 AMD22429.1 - 0.0012 18.5 5.8 0.38 10.3 0.0 3.7 4 0 0 4 4 4 2 Archaeal ATPase NB-ARC PF00931.17 AMD22429.1 - 0.0027 16.6 0.0 2 7.2 0.0 2.8 2 1 0 2 2 2 1 NB-ARC domain AAA_5 PF07728.9 AMD22429.1 - 0.0047 16.6 0.1 2.7 7.7 0.1 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 AMD22429.1 - 0.0072 15.2 0.4 2.6 6.9 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) SbcCD_C PF13558.1 AMD22429.1 - 0.012 15.5 0.7 1.3 8.9 0.0 3.5 3 2 0 3 3 2 0 Putative exonuclease SbcCD, C subunit NTPase_1 PF03266.10 AMD22429.1 - 0.014 15.1 2.0 0.42 10.3 0.1 2.8 3 0 0 3 3 2 0 NTPase T2SE PF00437.15 AMD22429.1 - 0.016 14.1 0.0 0.51 9.1 0.0 2.5 2 1 0 2 2 2 0 Type II/IV secretion system protein Dynamin_N PF00350.18 AMD22429.1 - 0.019 14.7 5.5 0.89 9.3 0.0 3.8 3 1 1 4 4 4 0 Dynamin family PduV-EutP PF10662.4 AMD22429.1 - 0.021 14.3 0.2 6.6 6.2 0.1 3.1 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 AMD22429.1 - 0.021 14.4 2.1 0.95 9.0 0.0 3.2 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.10 AMD22429.1 - 0.034 12.8 0.1 3.4 6.2 0.0 2.7 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein DAP3 PF10236.4 AMD22429.1 - 0.041 12.8 1.8 6 5.7 0.1 2.9 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 FeoB_N PF02421.13 AMD22429.1 - 0.076 12.2 0.0 2 7.6 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B UPF0079 PF02367.12 AMD22429.1 - 0.083 12.5 0.0 10 5.7 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 SRP54 PF00448.17 AMD22429.1 - 3.1 7.1 7.6 2.6 7.4 0.0 3.6 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain DUF87 PF01935.12 AMD22429.1 - 4.5 7.0 11.3 11 5.7 0.0 3.9 4 1 1 5 5 3 0 Domain of unknown function DUF87 NIF3 PF01784.13 AMD22432.1 - 8.6e-61 205.5 0.0 1e-60 205.2 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.13 AMD22433.1 - 1.5e-16 60.1 0.0 2.5e-16 59.3 0.0 1.4 1 1 0 1 1 1 1 BolA-like protein Kinesin PF00225.18 AMD22435.1 - 6.3e-112 373.5 0.3 1.1e-111 372.7 0.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain Cyclin PF08613.6 AMD22436.1 - 4.8e-05 23.7 0.6 0.0001 22.7 0.0 1.8 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 AMD22436.1 - 0.023 14.2 0.0 0.055 13.0 0.0 1.6 1 1 0 1 1 1 0 Cyclin, N-terminal domain WD40 PF00400.27 AMD22437.1 - 4.7e-16 57.9 20.7 1.4e-07 31.0 0.1 5.7 7 0 0 7 7 7 4 WD domain, G-beta repeat Rhamnogal_lyase PF06045.6 AMD22437.1 - 0.014 14.7 0.1 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Rhamnogalacturonate lyase family PX PF00787.19 AMD22438.1 - 1.6e-14 53.6 1.6 4.3e-14 52.2 0.2 2.1 2 1 0 2 2 2 1 PX domain SNARE PF05739.14 AMD22438.1 - 4.2e-07 29.5 7.2 1e-06 28.3 5.0 1.7 1 0 0 1 1 1 1 SNARE domain DUF2312 PF10073.4 AMD22438.1 - 0.054 12.8 1.8 0.32 10.3 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF3806 PF12713.2 AMD22438.1 - 0.075 12.5 0.0 0.21 11.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3806) ATP_bind_3 PF01171.15 AMD22439.1 - 2.8e-18 66.0 0.0 5e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 PP-loop family DUF2392 PF10288.4 AMD22439.1 - 0.00086 19.6 0.0 0.0017 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) tRNA_Me_trans PF03054.11 AMD22439.1 - 0.0079 14.7 0.0 0.014 13.9 0.0 1.3 1 1 0 1 1 1 1 tRNA methyl transferase TF_Zn_Ribbon PF08271.7 AMD22439.1 - 0.85 8.9 8.2 3.5 7.0 0.1 3.2 3 0 0 3 3 3 0 TFIIB zinc-binding Ras PF00071.17 AMD22442.1 - 1.6e-60 203.1 0.6 2e-60 202.8 0.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22442.1 - 2.3e-19 70.0 0.0 4.4e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD22442.1 - 4.7e-14 52.0 0.0 6.5e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 AMD22442.1 - 3.8e-07 30.0 0.0 7.7e-07 29.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD22442.1 - 4.1e-05 23.1 0.1 0.00019 20.8 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 AMD22442.1 - 9.4e-05 21.6 0.1 0.00013 21.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_15 PF13175.1 AMD22442.1 - 0.00018 20.7 0.4 0.00035 19.7 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 AMD22442.1 - 0.00068 18.8 0.1 0.0015 17.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 PduV-EutP PF10662.4 AMD22442.1 - 0.0057 16.1 0.0 0.011 15.1 0.0 1.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 AMD22442.1 - 0.0066 16.5 0.0 0.018 15.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain TraG_N PF07916.6 AMD22442.1 - 0.014 13.8 0.2 0.017 13.5 0.1 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region FeoB_N PF02421.13 AMD22442.1 - 0.022 14.0 0.1 0.051 12.8 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_14 PF13173.1 AMD22442.1 - 0.024 14.5 0.0 0.05 13.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.5 AMD22442.1 - 0.028 13.6 0.1 0.077 12.2 0.0 1.7 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit SpoIIID PF12116.3 AMD22442.1 - 0.042 13.7 0.0 0.92 9.4 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D ABC_tran PF00005.22 AMD22442.1 - 0.067 13.4 1.6 0.18 12.0 1.1 1.9 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.1 AMD22442.1 - 0.069 13.1 0.1 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain NDT80_PhoG PF05224.7 AMD22442.1 - 0.077 12.9 0.0 0.079 12.9 0.0 1.2 1 0 0 1 1 1 0 NDT80 / PhoG like DNA-binding family AAA_16 PF13191.1 AMD22442.1 - 0.086 12.8 0.4 0.2 11.6 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 AMD22442.1 - 0.089 12.5 0.0 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 AMD22442.1 - 0.093 13.0 0.0 0.29 11.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain Formyl_trans_N PF00551.14 AMD22442.1 - 0.11 12.0 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Formyl transferase CHZ PF09649.5 AMD22443.1 - 4.3e-19 67.4 2.3 4.3e-19 67.4 1.6 2.8 3 1 0 3 3 3 1 Histone chaperone domain CHZ Prothymosin PF03247.9 AMD22443.1 - 8.8 6.5 43.2 0.34 11.0 7.4 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family LSM PF01423.17 AMD22444.1 - 1.4e-15 56.6 0.0 2.9e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 LSM domain SR-25 PF10500.4 AMD22444.1 - 0.00012 21.6 8.9 0.00016 21.2 6.2 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Nucleo_P87 PF07267.6 AMD22444.1 - 0.018 13.7 5.0 0.018 13.7 3.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SprA-related PF12118.3 AMD22444.1 - 0.025 13.9 22.9 0.029 13.7 15.9 1.1 1 0 0 1 1 1 0 SprA-related family DUF913 PF06025.7 AMD22444.1 - 0.16 10.6 6.2 0.2 10.3 4.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDK5_activator PF03261.10 AMD22444.1 - 0.16 11.2 11.8 0.17 11.1 8.2 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Serinc PF03348.10 AMD22444.1 - 0.17 10.5 4.8 0.2 10.3 3.3 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Suf PF05843.9 AMD22444.1 - 0.23 11.1 18.8 0.28 10.8 13.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PBP_sp32 PF07222.7 AMD22444.1 - 0.32 10.1 9.6 0.34 10.0 6.7 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Gag_spuma PF03276.9 AMD22444.1 - 0.35 9.1 19.2 0.44 8.8 13.3 1.3 1 0 0 1 1 1 0 Spumavirus gag protein DDHD PF02862.12 AMD22444.1 - 0.54 10.0 10.2 0.69 9.6 7.1 1.2 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.5 AMD22444.1 - 0.59 8.2 33.9 0.68 8.0 23.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4407 PF14362.1 AMD22444.1 - 1.2 7.9 11.3 1.4 7.8 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.8 AMD22444.1 - 1.7 8.4 22.0 2.1 8.1 15.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM60A PF15396.1 AMD22444.1 - 1.8 8.2 14.3 2.4 7.8 9.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A PAT1 PF09770.4 AMD22444.1 - 2.4 6.2 34.6 3.1 5.9 24.0 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Hid1 PF12722.2 AMD22444.1 - 4.7 4.7 10.7 5 4.6 7.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MMR1 PF08505.5 AMD22444.1 - 8.2 6.3 21.6 12 5.8 15.0 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein zf-H2C2_2 PF13465.1 AMD22445.1 - 2.3e-08 33.9 23.7 1e-06 28.7 2.9 3.6 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 AMD22445.1 - 1.3e-07 31.5 20.2 2.5e-05 24.3 2.1 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22445.1 - 0.00015 21.8 1.5 0.00015 21.8 1.1 3.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AMD22445.1 - 0.14 12.3 1.3 0.14 12.3 0.9 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF629 PF04780.7 AMD22445.1 - 0.14 10.6 3.8 1.6 7.1 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) AMPKBI PF04739.10 AMD22446.1 - 4.5e-31 106.7 2.5 1.1e-30 105.4 1.7 1.7 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain SPT16 PF08644.6 AMD22447.1 - 1.9e-53 180.3 0.2 5.7e-53 178.8 0.1 1.9 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 AMD22447.1 - 4.1e-48 162.9 1.3 2.2e-47 160.6 0.0 2.5 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 AMD22447.1 - 4.6e-27 94.9 0.0 7.6e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 AMD22447.1 - 2.6e-18 65.7 0.4 1.7e-17 63.1 0.1 2.4 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Clathrin PF00637.15 AMD22448.1 - 1.7e-191 627.4 49.9 1.4e-31 109.0 0.6 8.9 9 0 0 9 9 9 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 AMD22448.1 - 1.3e-23 82.6 2.8 1.8e-23 82.1 0.0 2.9 3 0 0 3 3 3 1 Clathrin-H-link Clathrin_propel PF01394.15 AMD22448.1 - 2e-13 49.6 6.3 0.0062 16.7 0.2 6.0 6 0 0 6 6 6 4 Clathrin propeller repeat Clathrin-link PF09268.5 AMD22448.1 - 8.3e-08 31.1 0.1 8.3e-08 31.1 0.0 2.7 3 0 0 3 3 3 1 Clathrin, heavy-chain linker TPR_12 PF13424.1 AMD22448.1 - 9.2e-05 22.3 11.8 0.42 10.5 0.5 6.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 AMD22448.1 - 0.0037 17.5 3.7 3.9 7.8 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 AMD22448.1 - 0.0057 16.2 11.4 0.16 11.6 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD22448.1 - 0.015 15.2 8.6 2.2 8.3 0.0 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.1 AMD22448.1 - 0.027 14.1 16.5 0.6 9.7 0.6 5.7 5 0 0 5 5 5 0 TPR repeat RcbX PF02341.10 AMD22448.1 - 0.029 14.4 0.0 3.5 7.7 0.0 2.7 2 0 0 2 2 2 0 RbcX protein Vps39_1 PF10366.4 AMD22448.1 - 0.061 13.3 12.7 1.6 8.8 0.1 6.3 6 0 0 6 6 6 0 Vacuolar sorting protein 39 domain 1 TPR_17 PF13431.1 AMD22448.1 - 0.068 13.3 3.6 2.3 8.6 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ACOX PF01756.14 AMD22449.1 - 7.1e-45 152.6 0.1 1.2e-44 151.9 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.14 AMD22449.1 - 1.8e-16 59.3 1.1 5.7e-16 57.7 0.7 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 AMD22449.1 - 4.4e-07 30.2 0.0 8.3e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.19 AMD22449.1 - 1.9e-05 24.7 0.0 0.01 15.9 0.0 2.6 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain SDH_beta PF03315.10 AMD22449.1 - 0.019 14.9 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 Serine dehydratase beta chain CDP-OH_P_transf PF01066.16 AMD22450.1 - 7e-11 42.3 4.6 1.2e-10 41.6 3.2 1.4 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase DUF2420 PF10336.4 AMD22451.1 - 5e-34 116.3 0.5 8.8e-34 115.5 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) PB1 PF00564.19 AMD22451.1 - 0.059 13.0 0.3 0.23 11.1 0.1 2.1 2 0 0 2 2 2 0 PB1 domain DUF4278 PF14105.1 AMD22451.1 - 0.1 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4278) Ppx-GppA PF02541.11 AMD22452.1 - 6.5e-61 206.0 0.0 8.5e-61 205.6 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family SAC3_GANP PF03399.11 AMD22453.1 - 2.5e-27 95.7 1.5 3.4e-27 95.3 1.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 AMD22453.1 - 1.2e-19 70.5 0.8 1.7e-19 70.0 0.6 1.2 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Hexokinase_2 PF03727.11 AMD22454.1 - 3.4e-96 321.1 0.0 7e-96 320.1 0.0 1.5 2 0 0 2 2 2 1 Hexokinase Hexokinase_1 PF00349.16 AMD22454.1 - 3.5e-80 268.1 0.0 4.8e-80 267.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Glyco_hydro_2_N PF02837.13 AMD22455.1 - 7.6e-08 32.0 0.1 1.9e-07 30.7 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 AMD22455.1 - 2e-05 25.0 0.0 0.00013 22.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Asp PF00026.18 AMD22456.1 - 2.5e-73 247.0 0.5 4e-73 246.4 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD22456.1 - 9.7e-11 41.8 0.3 1.8e-10 41.0 0.1 1.6 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 AMD22456.1 - 0.0012 18.4 0.1 0.03 13.8 0.0 2.6 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 AMD22456.1 - 0.0053 17.2 0.9 1.9 9.0 0.2 3.1 2 1 0 2 2 2 1 Aspartyl protease Asp PF00026.18 AMD22457.1 - 3.1e-76 256.6 0.7 3.7e-76 256.4 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 AMD22457.1 - 1.9e-11 44.1 0.0 3.7e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 AMD22457.1 - 0.009 15.5 0.0 0.027 14.0 0.0 1.9 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 AMD22457.1 - 0.009 16.4 2.3 1.7 9.1 0.8 3.3 2 1 0 2 2 2 1 Aspartyl protease RVP PF00077.15 AMD22457.1 - 0.033 14.1 0.1 2.6 8.0 0.0 2.6 2 0 0 2 2 2 0 Retroviral aspartyl protease AA_permease_2 PF13520.1 AMD22458.1 - 7.2e-87 291.6 45.2 8.7e-87 291.3 31.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AMD22458.1 - 8.9e-21 73.7 41.1 1.4e-20 73.0 28.5 1.2 1 0 0 1 1 1 1 Amino acid permease Peptidase_M16 PF00675.15 AMD22459.1 - 1.5e-24 86.4 0.1 2.4e-24 85.7 0.1 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 AMD22459.1 - 1.8e-09 37.5 0.1 1e-08 35.1 0.0 2.2 2 1 0 2 2 2 1 Peptidase M16 inactive domain RNA_pol_Rpc82 PF05645.8 AMD22460.1 - 3.8e-60 203.6 0.1 5.9e-60 202.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.6 AMD22460.1 - 2.1e-19 69.1 4.6 2.7e-18 65.5 0.2 3.4 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.12 AMD22460.1 - 5.5e-06 25.8 0.7 0.14 11.6 0.1 2.9 2 0 0 2 2 2 2 TFIIE alpha subunit TPR_11 PF13414.1 AMD22461.1 - 1e-32 111.5 18.0 3.7e-08 32.8 0.0 13.2 8 4 6 14 14 14 8 TPR repeat TPR_19 PF14559.1 AMD22461.1 - 5.9e-29 100.2 0.1 3.8e-07 30.3 0.0 9.2 7 2 2 9 9 8 5 Tetratricopeptide repeat TPR_2 PF07719.12 AMD22461.1 - 3e-27 92.2 10.8 0.00029 20.5 0.0 13.6 14 0 0 14 14 13 5 Tetratricopeptide repeat TPR_16 PF13432.1 AMD22461.1 - 8.3e-24 83.6 0.2 0.0022 18.6 0.1 9.5 9 2 2 11 11 10 6 Tetratricopeptide repeat TPR_1 PF00515.23 AMD22461.1 - 5.5e-23 79.5 9.9 6.9e-05 22.2 0.0 12.0 12 1 0 12 12 12 4 Tetratricopeptide repeat TPR_12 PF13424.1 AMD22461.1 - 5.1e-22 77.6 10.5 0.0013 18.6 0.0 10.0 7 4 3 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.1 AMD22461.1 - 5e-18 63.9 0.4 0.086 13.5 0.0 12.0 8 4 6 14 14 12 4 Tetratricopeptide repeat TPR_17 PF13431.1 AMD22461.1 - 1.6e-17 62.2 7.7 0.0077 16.3 0.0 12.2 14 0 0 14 14 12 2 Tetratricopeptide repeat TPR_8 PF13181.1 AMD22461.1 - 4.9e-15 54.0 10.7 0.0009 18.8 0.0 10.8 11 1 1 12 12 10 2 Tetratricopeptide repeat Apc3 PF12895.2 AMD22461.1 - 5.5e-15 55.2 5.8 3.9e-05 23.7 0.0 6.9 6 1 1 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 AMD22461.1 - 2.4e-11 43.2 1.0 25 5.6 0.0 11.6 13 0 0 13 13 11 0 Tetratricopeptide repeat TPR_7 PF13176.1 AMD22461.1 - 2e-07 30.3 0.9 0.028 14.1 0.0 7.8 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_9 PF13371.1 AMD22461.1 - 1.4e-06 28.0 0.6 0.2 11.5 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.1 AMD22461.1 - 4.1e-05 23.5 2.6 5.5 7.1 0.0 6.6 6 1 1 7 7 6 1 Tetratricopeptide repeat Coatomer_E PF04733.9 AMD22461.1 - 6.1e-05 22.3 0.7 0.0014 17.9 0.0 2.6 2 0 0 2 2 2 1 Coatomer epsilon subunit Fis1_TPR_C PF14853.1 AMD22461.1 - 0.022 14.6 0.0 0.23 11.3 0.0 2.7 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat HrpB1_HrpK PF09613.5 AMD22461.1 - 0.033 13.6 0.0 0.083 12.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_4 PF07721.9 AMD22461.1 - 0.039 14.3 0.0 88 3.9 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat EF-hand_6 PF13405.1 AMD22462.1 - 0.00011 21.7 1.9 0.00022 20.8 0.2 2.4 3 1 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 AMD22462.1 - 0.00014 20.8 0.6 0.0006 18.9 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 AMD22462.1 - 0.00094 19.2 0.1 0.003 17.6 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 AMD22462.1 - 0.061 12.6 2.1 0.12 11.7 0.7 2.1 2 0 0 2 2 2 0 EF hand RNA_pol_Rpb6 PF01192.17 AMD22463.1 - 5e-23 80.6 0.2 7.3e-23 80.0 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 zf-C2H2 PF00096.21 AMD22464.1 - 7.1e-31 104.6 66.8 0.00014 22.0 2.0 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22464.1 - 1e-24 84.9 60.6 0.00077 19.6 1.5 9.3 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD22464.1 - 8.8e-16 57.3 70.4 2.2e-05 24.4 1.5 9.8 10 0 0 10 10 10 8 Zinc-finger double domain zf-C2H2_jaz PF12171.3 AMD22464.1 - 3e-08 33.5 44.3 0.0099 16.0 0.0 8.5 10 0 0 10 10 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 AMD22464.1 - 0.00039 20.5 43.3 0.046 13.9 1.4 8.7 10 0 0 10 10 10 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 AMD22464.1 - 0.017 15.3 0.4 0.017 15.3 0.3 8.5 9 3 0 9 9 7 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.2 AMD22464.1 - 0.042 13.9 40.5 0.6 10.2 0.5 5.8 2 1 0 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF3797 PF12677.2 AMD22464.1 - 0.047 13.3 0.6 0.047 13.3 0.4 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3797) Zn_Tnp_IS1595 PF12760.2 AMD22464.1 - 0.15 11.8 21.7 1.2 9.0 0.6 4.9 4 1 0 4 4 4 0 Transposase zinc-ribbon domain Trm112p PF03966.11 AMD22464.1 - 0.23 11.8 2.9 13 6.2 0.6 3.0 2 1 0 2 2 2 0 Trm112p-like protein A2L_zn_ribbon PF08792.5 AMD22464.1 - 1.3 8.5 17.0 2.3 7.7 0.3 5.1 5 0 0 5 5 5 0 A2L zinc ribbon domain HypA PF01155.14 AMD22464.1 - 1.6 8.4 15.7 1 9.0 0.3 3.6 1 1 2 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-HYPF PF07503.7 AMD22464.1 - 2.6 7.5 6.4 14 5.2 0.1 3.6 3 0 0 3 3 3 0 HypF finger XPA_N PF01286.13 AMD22464.1 - 7.9 6.2 18.6 4.1 7.1 0.1 5.3 5 0 0 5 5 5 0 XPA protein N-terminal G-alpha PF00503.15 AMD22465.1 - 2.7e-113 378.6 0.2 2.9e-113 378.5 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 AMD22465.1 - 1.4e-13 50.4 0.6 2.2e-09 36.7 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 AMD22465.1 - 0.00022 21.7 0.0 0.72 10.3 0.0 2.5 2 0 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 AMD22465.1 - 0.00028 20.1 2.1 0.011 14.8 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 AMD22465.1 - 0.011 15.6 0.0 0.65 9.9 0.0 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.1 AMD22465.1 - 0.02 14.8 1.6 0.027 14.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 AMD22465.1 - 0.087 12.3 0.1 0.19 11.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Lipase_3 PF01764.20 AMD22466.1 - 1.1e-37 128.7 0.0 3.2e-37 127.2 0.0 1.7 2 0 0 2 2 2 1 Lipase (class 3) Esterase PF00756.15 AMD22466.1 - 0.056 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Na_Ca_ex PF01699.19 AMD22467.1 - 9e-38 129.0 28.9 3.2e-22 78.6 7.0 3.7 3 2 1 4 4 4 2 Sodium/calcium exchanger protein PfkB PF00294.19 AMD22468.1 - 2e-67 227.4 0.5 2.4e-67 227.1 0.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 AMD22468.1 - 0.0039 16.4 0.0 0.0071 15.5 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase STAT2_C PF12188.3 AMD22468.1 - 0.099 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal TRAM_LAG1_CLN8 PF03798.11 AMD22469.1 - 4.9e-25 88.2 18.5 7.7e-25 87.5 12.8 1.3 1 0 0 1 1 1 1 TLC domain DUF2645 PF10840.3 AMD22469.1 - 0.01 15.9 0.9 0.01 15.9 0.6 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2645) Peptidase_M48 PF01435.13 AMD22470.1 - 4.8e-50 170.2 0.0 6.4e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.6 AMD22470.1 - 0.032 13.1 0.1 0.079 11.9 0.1 1.7 1 1 0 1 1 1 0 BlaR1 peptidase M56 DUF2268 PF10026.4 AMD22470.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) Rpn3_C PF08375.6 AMD22471.1 - 1.2e-20 73.6 0.8 3.2e-20 72.2 0.3 1.9 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 AMD22471.1 - 4.3e-20 71.9 0.8 1.4e-19 70.3 0.6 2.0 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 AMD22471.1 - 0.0049 16.6 0.1 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 COP9 signalosome, subunit CSN8 MarR_2 PF12802.2 AMD22471.1 - 0.0072 15.9 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 MarR family TPR_2 PF07719.12 AMD22471.1 - 0.074 13.0 2.9 4.5 7.4 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3746 PF12562.3 AMD22471.1 - 0.22 11.4 1.8 0.35 10.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3746) Med17 PF10156.4 AMD22472.1 - 1.4e-130 435.7 11.1 1.8e-130 435.3 7.7 1.0 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Ilm1 PF10311.4 AMD22473.1 - 1.4e-38 131.9 7.5 2.1e-38 131.4 5.2 1.2 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 V_ATPase_I PF01496.14 AMD22473.1 - 0.0063 14.4 0.0 0.0081 14.0 0.0 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF3147 PF11345.3 AMD22473.1 - 0.029 14.3 0.1 0.046 13.7 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3147) JmjC PF02373.17 AMD22474.1 - 2.2e-39 134.2 0.5 5.3e-39 133.0 0.3 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 AMD22474.1 - 7.2e-13 47.8 0.0 2.1e-12 46.3 0.0 1.9 1 0 0 1 1 1 1 jmjN domain PHD PF00628.24 AMD22474.1 - 1.2e-09 37.6 9.5 1.2e-09 37.6 6.6 2.4 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.1 AMD22474.1 - 0.0013 18.4 10.8 0.0022 17.7 6.3 2.3 2 0 0 2 2 2 1 Ring finger domain PHD_2 PF13831.1 AMD22474.1 - 0.0019 17.4 4.2 0.0019 17.4 2.9 2.7 2 0 0 2 2 2 1 PHD-finger ARID PF01388.16 AMD22474.1 - 0.018 14.8 0.2 6.6 6.6 0.1 2.5 2 0 0 2 2 2 0 ARID/BRIGHT DNA binding domain Spore_coat_CotO PF14153.1 AMD22474.1 - 0.12 11.8 8.4 0.027 13.9 3.6 1.6 2 0 0 2 2 2 0 Spore coat protein CotO PHD_3 PF13922.1 AMD22474.1 - 0.32 11.2 9.0 0.027 14.6 2.3 2.1 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx Prok-RING_1 PF14446.1 AMD22474.1 - 0.43 10.3 13.3 0.024 14.3 4.3 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.17 AMD22474.1 - 0.69 9.6 9.0 0.18 11.5 2.3 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Nop14 PF04147.7 AMD22474.1 - 3.4 5.4 18.2 6.5 4.5 12.6 1.3 1 0 0 1 1 1 0 Nop14-like family P5CR_dimer PF14748.1 AMD22475.1 - 5.2e-32 110.0 0.3 8.9e-32 109.2 0.2 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 AMD22475.1 - 2.6e-11 43.7 0.0 7e-11 42.4 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 AMD22475.1 - 0.0058 16.3 0.4 0.014 15.0 0.3 1.8 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 AMD22475.1 - 0.021 14.3 0.1 0.046 13.1 0.1 1.5 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA zf-RING_2 PF13639.1 AMD22477.1 - 3.1e-05 23.7 3.0 8.8e-05 22.2 2.1 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 AMD22477.1 - 0.013 15.1 3.4 0.041 13.5 2.3 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD22477.1 - 0.12 12.4 2.7 0.35 10.9 1.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SRP40_C PF05022.7 AMD22477.1 - 0.14 12.6 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 SRP40, C-terminal domain PHD PF00628.24 AMD22477.1 - 0.16 11.6 3.5 0.36 10.5 2.4 1.7 1 0 0 1 1 1 0 PHD-finger Peptidase_S64 PF08192.6 AMD22478.1 - 1.8e-229 763.6 0.2 2.3e-229 763.3 0.2 1.0 1 0 0 1 1 1 1 Peptidase family S64 Trypsin_2 PF13365.1 AMD22478.1 - 0.019 14.9 0.0 0.045 13.7 0.0 1.6 1 0 0 1 1 1 0 Trypsin-like peptidase domain 6PF2K PF01591.13 AMD22479.1 - 9.6e-85 283.1 0.0 1.3e-84 282.6 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 AMD22479.1 - 6.4e-30 104.3 0.0 1.7e-29 102.9 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 AMD22479.1 - 1.4e-06 28.2 0.0 2.5e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD22479.1 - 0.0035 18.1 0.2 0.036 14.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain Vps35 PF03635.12 AMD22480.1 - 4.7e-276 917.8 21.2 5.6e-276 917.6 14.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 DUF2762 PF10960.3 AMD22480.1 - 0.012 15.3 0.1 0.037 13.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) Pam17 PF08566.5 AMD22481.1 - 1.4e-70 236.4 0.1 1.7e-70 236.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 F-box-like PF12937.2 AMD22482.1 - 6.4e-08 32.2 1.5 3.9e-07 29.6 0.2 2.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 AMD22482.1 - 6.6e-07 28.8 0.1 2.7e-06 26.8 0.0 2.1 1 0 0 1 1 1 1 F-box domain Zn_clus PF00172.13 AMD22483.1 - 2.6e-09 36.8 8.8 7.1e-09 35.4 6.1 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GH114_assoc PF14741.1 AMD22483.1 - 0.041 13.6 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 N-terminal glycosyl-hydrolase-114-associated domain Latarcin PF10279.4 AMD22483.1 - 0.065 13.4 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Latarcin precursor Las1 PF04031.8 AMD22484.1 - 1.2e-48 164.6 0.0 2.3e-48 163.7 0.0 1.5 1 0 0 1 1 1 1 Las1-like Wbp11 PF09429.5 AMD22484.1 - 0.05 13.5 2.3 6.6 6.7 0.1 2.5 2 0 0 2 2 2 0 WW domain binding protein 11 Prefoldin_2 PF01920.15 AMD22484.1 - 0.24 11.1 5.2 1.2 8.8 0.6 2.7 2 0 0 2 2 2 0 Prefoldin subunit RNA_polI_A34 PF08208.6 AMD22485.1 - 7.5e-39 133.4 27.8 1e-38 133.0 19.3 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 GAGA_bind PF06217.7 AMD22485.1 - 0.14 12.1 13.7 0.18 11.7 9.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.9 AMD22485.1 - 6.6 4.6 13.8 9.3 4.1 9.5 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIE_beta PF02186.10 AMD22486.1 - 7.2e-23 80.3 0.3 1.4e-22 79.4 0.2 1.5 1 0 0 1 1 1 1 TFIIE beta subunit core domain DUF1639 PF07797.9 AMD22486.1 - 0.0033 16.7 0.0 0.0064 15.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1639) UPF0184 PF03670.8 AMD22487.1 - 0.29 11.3 4.4 11 6.2 0.0 3.4 4 1 1 5 5 5 0 Uncharacterised protein family (UPF0184) DUF479 PF04336.7 AMD22487.1 - 1 9.4 4.5 4.5 7.4 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function, DUF479 CRAL_TRIO PF00650.15 AMD22489.1 - 3.3e-24 85.1 0.0 4.5e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 AMD22489.1 - 8.9e-08 32.1 0.3 2.9e-07 30.5 0.2 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain SHNi-TPR PF10516.4 AMD22489.1 - 0.057 12.6 0.0 0.15 11.3 0.0 1.6 1 0 0 1 1 1 0 SHNi-TPR Tim17 PF02466.14 AMD22491.1 - 6.4e-32 110.2 5.4 7.5e-32 110.0 3.7 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Pkinase PF00069.20 AMD22492.1 - 1.1e-51 175.4 0.0 2.3e-51 174.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22492.1 - 2e-23 82.7 0.0 3.3e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AMD22492.1 - 0.0064 16.2 0.1 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 AMD22492.1 - 0.011 15.3 2.5 0.064 12.8 0.1 2.7 2 1 1 3 3 3 0 Choline/ethanolamine kinase RIO1 PF01163.17 AMD22492.1 - 0.049 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family RNA_pol_Rpb4 PF03874.11 AMD22493.1 - 3.3e-36 123.8 3.0 5.6e-36 123.0 2.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb4 RXT2_N PF08595.6 AMD22493.1 - 0.0086 15.8 2.4 0.0086 15.8 1.7 1.6 2 0 0 2 2 2 1 RXT2-like, N-terminal IncFII_repA PF02387.10 AMD22493.1 - 1.2 8.2 4.5 1.7 7.7 2.8 1.6 1 1 0 1 1 1 0 IncFII RepA protein family Glyco_transf_15 PF01793.11 AMD22494.1 - 9.9e-136 452.0 14.2 1.2e-135 451.7 9.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_L1 PF00687.16 AMD22495.1 - 5.2e-48 163.2 3.2 6.2e-48 163.0 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DEAD PF00270.24 AMD22496.1 - 2.8e-45 153.8 1.3 6.8e-45 152.5 0.3 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22496.1 - 1.4e-27 95.3 0.1 1.8e-26 91.8 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD22496.1 - 4.1e-05 23.4 0.1 0.00056 19.8 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 AMD22496.1 - 0.00083 19.0 0.8 0.0095 15.6 0.2 2.5 2 1 1 3 3 3 1 Part of AAA domain DUF1253 PF06862.7 AMD22496.1 - 0.0015 17.0 0.2 0.72 8.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1253) AAA_30 PF13604.1 AMD22496.1 - 0.014 15.0 0.1 0.043 13.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.1 AMD22496.1 - 0.022 13.8 0.0 0.059 12.4 0.0 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_C_2 PF13307.1 AMD22496.1 - 0.051 13.5 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain Glyco_transf_8 PF01501.15 AMD22497.1 - 1.7e-28 99.6 0.0 2.6e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Gasdermin PF04598.7 AMD22497.1 - 0.12 11.0 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Gasdermin family Ribosomal_S21e PF01249.13 AMD22498.1 - 5.9e-40 135.1 0.0 6.4e-40 134.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e AFG1_ATPase PF03969.11 AMD22499.1 - 2.9e-75 253.3 0.0 1.5e-71 241.1 0.0 2.5 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.1 AMD22499.1 - 0.00041 20.3 0.7 0.19 11.7 0.0 2.7 1 1 1 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 AMD22499.1 - 0.0041 17.2 0.1 0.016 15.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 AMD22499.1 - 0.0067 16.6 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 AMD22499.1 - 0.029 14.0 0.0 0.096 12.3 0.0 1.9 1 1 0 1 1 1 0 Archaeal ATPase RNA_helicase PF00910.17 AMD22499.1 - 0.046 13.8 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase TPR_14 PF13428.1 AMD22500.1 - 3.7e-09 36.4 0.1 2.1 9.1 0.0 7.8 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 AMD22500.1 - 2.8e-06 27.5 0.3 0.02 15.2 0.0 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD22500.1 - 0.00019 20.9 0.5 0.009 15.7 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 AMD22500.1 - 0.00065 19.5 4.2 0.18 11.7 0.0 4.7 6 0 0 6 6 6 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 AMD22500.1 - 0.0017 18.0 8.8 1.3 8.7 0.2 5.6 6 1 0 6 6 6 2 Mad3/BUB1 homology region 1 TPR_7 PF13176.1 AMD22500.1 - 0.007 16.0 0.4 3 7.8 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 AMD22500.1 - 0.011 15.5 7.7 0.15 12.0 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.1 AMD22500.1 - 0.015 14.9 9.9 0.091 12.4 0.1 4.4 5 0 0 5 5 5 0 TPR repeat TPR_1 PF00515.23 AMD22500.1 - 0.055 13.0 1.1 2.7 7.7 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.4 AMD22500.1 - 0.059 12.7 3.4 0.31 10.3 0.0 3.6 5 0 0 5 5 5 0 26S proteasome subunit RPN7 NRDE-2 PF08424.5 AMD22500.1 - 0.28 10.0 13.0 1.8 7.3 0.3 5.0 4 2 1 5 5 5 0 NRDE-2, necessary for RNA interference TPR_6 PF13174.1 AMD22500.1 - 0.29 11.6 2.6 40 4.9 0.0 4.9 7 0 0 7 7 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 AMD22500.1 - 0.61 10.4 11.4 3.1 8.2 0.3 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat ATP-synt_D PF01813.12 AMD22501.1 - 1.5e-63 213.8 1.9 1.8e-63 213.6 1.3 1.1 1 0 0 1 1 1 1 ATP synthase subunit D Nup54 PF13874.1 AMD22501.1 - 0.08 12.6 4.0 1 9.0 0.3 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Ribosomal_L2_C PF03947.13 AMD22502.1 - 1.4e-48 163.9 1.0 2.7e-48 163.0 0.7 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 AMD22502.1 - 2.7e-28 97.7 0.7 6.8e-28 96.4 0.3 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain EXS PF03124.9 AMD22503.1 - 1.9e-60 204.7 22.2 2.1e-60 204.5 15.4 1.0 1 0 0 1 1 1 1 EXS family Nop25 PF09805.4 AMD22504.1 - 4.1e-34 117.5 17.6 4.1e-34 117.5 12.2 1.5 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) PA26 PF04636.8 AMD22504.1 - 0.62 8.6 6.3 0.79 8.3 4.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PAPS_reduct PF01507.14 AMD22504.1 - 8.7 6.1 7.0 6 6.6 3.7 1.6 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Thioredoxin PF00085.15 AMD22505.1 - 2.4e-28 97.8 0.0 3.8e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin DER1 PF04511.10 AMD22505.1 - 3.6e-21 75.5 19.3 4.6e-21 75.2 13.4 1.1 1 0 0 1 1 1 1 Der1-like family Thioredoxin_2 PF13098.1 AMD22505.1 - 5.8e-07 29.7 0.1 4.5e-06 26.8 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 AMD22505.1 - 2.1e-05 24.5 0.1 0.00042 20.3 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.16 AMD22505.1 - 0.00034 20.2 0.0 0.00063 19.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.1 AMD22505.1 - 0.0018 18.2 0.0 0.0039 17.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like DIM1 PF02966.11 AMD22505.1 - 0.0021 17.5 0.0 0.005 16.3 0.0 1.6 2 0 0 2 2 2 1 Mitosis protein DIM1 Redoxin PF08534.5 AMD22505.1 - 0.0054 16.2 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.1 AMD22505.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Glutaredoxin PF00462.19 AMD22505.1 - 0.019 14.9 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin TraF PF13728.1 AMD22505.1 - 0.057 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein Phosducin PF02114.11 AMD22505.1 - 0.084 11.5 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Phosducin MNHE PF01899.11 AMD22505.1 - 0.37 10.4 3.8 0.49 10.0 2.3 1.6 1 1 0 1 1 1 0 Na+/H+ ion antiporter subunit Carn_acyltransf PF00755.15 AMD22506.1 - 3e-170 567.1 0.1 3.5e-170 566.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-HIT PF04438.11 AMD22507.1 - 0.0026 17.3 11.4 0.0026 17.3 7.9 2.0 2 0 0 2 2 2 1 HIT zinc finger ICMT PF04140.9 AMD22508.1 - 3.8e-30 103.9 0.9 6.9e-30 103.1 0.6 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 AMD22508.1 - 1.4e-16 60.4 1.6 1.4e-16 60.4 1.1 1.7 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 AMD22508.1 - 0.00027 20.3 2.5 0.00034 19.9 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF4149 PF13664.1 AMD22508.1 - 7.4 6.7 9.1 2.4 8.2 4.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) PINIT PF14324.1 AMD22509.1 - 1.3e-33 116.1 0.0 1.3e-33 116.1 0.0 3.1 3 1 1 4 4 4 1 PINIT domain zf-MIZ PF02891.15 AMD22509.1 - 5.4e-21 73.8 5.2 9.4e-21 73.0 3.6 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.22 AMD22509.1 - 7.6e-12 44.4 0.1 1.3e-11 43.6 0.1 1.4 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.3 AMD22509.1 - 7.9e-06 25.2 1.8 1.7e-05 24.2 1.3 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.1 AMD22509.1 - 0.043 13.6 3.8 0.084 12.7 2.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 AMD22509.1 - 0.082 12.9 3.1 0.15 12.0 2.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD22509.1 - 0.14 11.8 1.8 0.25 11.0 1.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD22509.1 - 0.57 10.0 2.8 1 9.2 1.9 1.4 1 0 0 1 1 1 0 Ring finger domain Formyl_trans_N PF00551.14 AMD22510.1 - 3.1e-47 160.4 0.0 3.8e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase MannoseP_isomer PF01050.13 AMD22510.1 - 0.025 14.2 0.1 0.044 13.3 0.1 1.4 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Proteasome PF00227.21 AMD22511.1 - 1.7e-48 164.4 0.0 2.4e-48 163.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 AMD22511.1 - 4.3e-11 41.8 0.2 9.2e-11 40.8 0.1 1.6 1 0 0 1 1 1 1 Proteasome beta subunits C terminal TRAPPC9-Trs120 PF08626.6 AMD22512.1 - 2.8e-211 703.9 20.9 2.6e-210 700.7 14.5 1.9 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit LSM PF01423.17 AMD22514.1 - 5.7e-13 48.2 0.1 6.7e-13 47.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain Xpo1 PF08389.7 AMD22515.1 - 3.2e-30 104.9 1.0 1.5e-28 99.5 0.2 3.7 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.14 AMD22515.1 - 8.1e-07 28.8 0.4 4.2e-05 23.3 0.1 3.5 3 1 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.17 AMD22515.1 - 0.068 13.2 0.0 32 4.9 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat F-box-like PF12937.2 AMD22516.1 - 2.6 7.8 0.0 2.6 7.8 0.0 2.8 3 1 0 3 3 3 0 F-box-like Choline_transpo PF04515.7 AMD22517.1 - 2.8e-97 325.4 16.9 2.8e-97 325.4 11.7 2.0 2 0 0 2 2 2 1 Plasma-membrane choline transporter ISN1 PF06437.6 AMD22518.1 - 9e-166 551.6 0.0 1.1e-165 551.3 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase DDHD PF02862.12 AMD22520.1 - 2.5e-40 138.6 0.2 1.7e-27 96.6 0.1 2.4 1 1 1 2 2 2 2 DDHD domain LCAT PF02450.10 AMD22520.1 - 2.5e-06 26.7 0.1 5.1e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.9 AMD22520.1 - 4.8e-05 22.7 0.0 0.014 14.6 0.0 2.3 2 0 0 2 2 2 2 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 AMD22520.1 - 0.066 12.9 0.0 0.32 10.7 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.8 AMD22520.1 - 0.08 12.5 0.0 0.31 10.5 0.0 1.8 2 0 0 2 2 2 0 PGAP1-like protein RNA_Me_trans PF04252.8 AMD22521.1 - 1.2e-74 250.0 0.0 1.3e-74 249.8 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Cpn10 PF00166.16 AMD22522.1 - 8.9e-27 92.8 0.1 1e-26 92.7 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit PRP3 PF08572.5 AMD22523.1 - 2.5e-59 200.3 18.9 2.5e-59 200.3 13.1 1.7 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 AMD22523.1 - 1.9e-30 105.1 0.5 1.9e-30 105.1 0.3 2.9 4 0 0 4 4 4 1 Protein of unknown function (DUF1115) YfhO PF09586.5 AMD22523.1 - 2.5 6.0 4.8 3.3 5.6 3.4 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Usp PF00582.21 AMD22524.1 - 0.024 14.8 1.9 0.12 12.6 0.0 2.7 2 1 0 2 2 2 0 Universal stress protein family 2Fe-2S_thioredx PF01257.14 AMD22524.1 - 0.19 11.3 0.0 0.58 9.7 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin-like [2Fe-2S] ferredoxin Arf PF00025.16 AMD22525.1 - 1.4e-30 105.8 0.1 4.3e-29 100.9 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.17 AMD22525.1 - 2.9e-15 56.0 0.0 4.9e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22525.1 - 2.7e-09 37.5 0.0 4.4e-08 33.6 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 AMD22525.1 - 7e-09 35.6 0.0 1.3e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 AMD22525.1 - 7.5e-06 25.5 0.0 0.00039 19.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain G-alpha PF00503.15 AMD22525.1 - 1.1e-05 24.3 0.1 0.0011 17.7 0.0 2.3 2 1 0 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 AMD22525.1 - 0.00092 18.4 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 AMD22525.1 - 0.0016 17.5 0.0 0.0022 17.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.18 AMD22525.1 - 0.0019 18.0 0.4 0.1 12.3 0.0 2.5 1 1 1 3 3 3 1 Dynamin family FeoB_N PF02421.13 AMD22525.1 - 0.1 11.8 0.0 0.26 10.5 0.0 1.7 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF2470 PF10615.4 AMD22526.1 - 1.6e-15 57.0 0.0 2.5e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pkinase PF00069.20 AMD22527.1 - 1.1e-75 254.1 0.0 1.7e-75 253.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22527.1 - 7.1e-38 130.1 0.0 1.1e-37 129.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 AMD22527.1 - 8.1e-16 57.9 1.8 8.1e-16 57.9 1.2 2.0 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 AMD22527.1 - 9.3e-10 37.9 0.0 2.4e-09 36.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like YukC PF10140.4 AMD22527.1 - 2e-05 23.3 0.2 3.7e-05 22.4 0.2 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.17 AMD22527.1 - 0.00011 21.6 0.7 0.00023 20.5 0.5 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 AMD22527.1 - 0.0031 16.6 0.1 0.0049 15.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 AMD22527.1 - 0.0046 16.7 0.1 0.72 9.5 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Ribosomal_L37ae PF01780.14 AMD22527.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family SIR2 PF02146.12 AMD22528.1 - 2.6e-36 125.0 0.0 2.1e-35 122.0 0.0 2.1 1 1 0 1 1 1 1 Sir2 family DUF2256 PF10013.4 AMD22528.1 - 0.013 15.2 0.3 0.032 13.9 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Rpr2 PF04032.11 AMD22529.1 - 6.1e-12 45.2 7.4 6.9e-12 45.0 1.5 2.1 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4617 PF15395.1 AMD22529.1 - 0.0019 16.3 5.1 0.0023 16.0 3.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4617) zf-ribbon_3 PF13248.1 AMD22529.1 - 0.039 13.1 4.0 0.47 9.7 0.3 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Pex24p PF06398.6 AMD22530.1 - 5.9e-84 281.9 8.3 8.5e-84 281.3 5.7 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin WD40 PF00400.27 AMD22531.1 - 9e-09 34.8 9.0 0.00089 19.0 0.0 4.3 5 1 0 5 5 5 3 WD domain, G-beta repeat PQQ_3 PF13570.1 AMD22531.1 - 0.005 17.0 2.1 19 5.6 0.1 4.0 4 0 0 4 4 4 2 PQQ-like domain DUF3553 PF12073.3 AMD22531.1 - 0.039 13.2 0.0 0.096 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3553) SET PF00856.23 AMD22532.1 - 3.2e-14 53.5 0.0 9.1e-14 52.0 0.0 1.8 1 1 0 1 1 1 1 SET domain SAF PF08666.7 AMD22532.1 - 0.11 12.9 0.0 21 5.5 0.0 2.4 2 0 0 2 2 2 0 SAF domain TPR_11 PF13414.1 AMD22533.1 - 5.1e-59 195.8 39.0 8.5e-16 57.3 0.4 6.4 3 3 5 8 8 8 7 TPR repeat TPR_1 PF00515.23 AMD22533.1 - 6e-47 155.4 25.6 3.5e-09 35.8 0.5 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.12 AMD22533.1 - 5.3e-41 135.2 26.8 7.6e-08 31.7 0.4 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 AMD22533.1 - 2.3e-25 88.3 17.7 1.9e-11 43.7 0.6 5.7 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.1 AMD22533.1 - 5.3e-25 87.4 11.5 9.4e-05 22.9 0.1 6.7 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.1 AMD22533.1 - 3.6e-20 70.0 15.9 2.2e-05 23.9 0.0 8.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 AMD22533.1 - 1.2e-19 68.9 9.3 0.022 15.3 0.2 9.9 5 3 5 10 10 9 5 Tetratricopeptide repeat TPR_8 PF13181.1 AMD22533.1 - 2.4e-19 67.5 27.5 3e-05 23.4 0.6 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.1 AMD22533.1 - 4e-15 55.8 20.3 0.00022 21.4 0.1 7.2 4 4 3 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.1 AMD22533.1 - 1.2e-13 50.6 3.4 1.4e-05 24.8 0.0 6.2 5 3 2 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 AMD22533.1 - 8.8e-13 47.3 12.8 0.002 18.1 0.0 7.8 7 1 1 8 8 8 3 Tetratricopeptide repeat Apc3 PF12895.2 AMD22533.1 - 5.7e-10 39.1 16.3 0.0023 18.0 0.4 4.3 3 1 2 5 5 5 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 AMD22533.1 - 1.2e-08 34.8 21.2 0.81 10.2 0.0 9.0 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_10 PF13374.1 AMD22533.1 - 6.5e-07 29.0 2.1 0.057 13.3 0.1 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_3 PF07720.7 AMD22533.1 - 4.9e-05 23.0 16.2 0.21 11.4 0.2 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat RPN7 PF10602.4 AMD22533.1 - 0.0003 20.2 18.1 0.46 9.8 0.5 5.2 3 3 2 5 5 5 3 26S proteasome subunit RPN7 SHNi-TPR PF10516.4 AMD22533.1 - 0.0028 16.8 8.2 1.7 7.9 0.0 6.5 7 0 0 7 7 7 1 SHNi-TPR BTAD PF03704.12 AMD22533.1 - 0.0065 16.7 5.4 0.56 10.5 0.0 4.6 3 2 1 4 4 4 1 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.1 AMD22533.1 - 0.01 15.6 11.4 2.1 8.3 0.1 5.8 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.7 AMD22533.1 - 0.011 16.3 3.9 10 6.9 0.0 4.3 3 0 0 3 3 3 0 Sel1 repeat TPR_20 PF14561.1 AMD22533.1 - 0.012 15.6 10.7 0.081 13.0 0.1 4.7 4 2 1 5 5 4 0 Tetratricopeptide repeat PPR PF01535.15 AMD22533.1 - 0.013 15.4 5.3 12 6.1 0.1 6.1 6 0 0 6 6 6 0 PPR repeat DUF3856 PF12968.2 AMD22533.1 - 0.22 11.3 11.8 9.3 6.0 1.1 5.3 2 2 2 4 4 4 0 Domain of Unknown Function (DUF3856) MIT PF04212.13 AMD22533.1 - 0.37 10.7 22.0 25 4.8 0.1 6.9 6 1 0 6 6 6 0 MIT (microtubule interacting and transport) domain Imm42 PF15601.1 AMD22533.1 - 0.85 9.0 3.8 5.9 6.3 0.1 3.3 3 0 0 3 3 3 0 Immunity protein 42 DUF627 PF04781.7 AMD22533.1 - 3.3 7.3 6.9 7.7 6.1 0.1 4.1 2 2 3 5 5 5 0 Protein of unknown function (DUF627) AAA_2 PF07724.9 AMD22534.1 - 4.1e-51 173.3 0.2 4.4e-49 166.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 AMD22534.1 - 6.1e-27 93.3 2.6 1.1e-26 92.5 0.1 2.6 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 AMD22534.1 - 1.2e-21 77.2 0.1 7.3e-11 42.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 AMD22534.1 - 3.4e-16 59.2 0.3 2.7e-11 43.3 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 AMD22534.1 - 8.8e-13 48.6 3.5 0.00028 20.9 0.0 4.3 3 2 2 5 5 4 3 AAA ATPase domain AAA_22 PF13401.1 AMD22534.1 - 1.6e-08 34.7 0.2 0.0019 18.3 0.0 3.3 3 1 0 3 3 2 2 AAA domain Sigma54_activat PF00158.21 AMD22534.1 - 5.3e-07 29.2 0.1 4.5e-05 23.0 0.0 2.5 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.1 AMD22534.1 - 5.3e-07 29.9 2.0 0.011 16.0 0.0 3.7 3 1 0 3 3 3 2 AAA domain IstB_IS21 PF01695.12 AMD22534.1 - 7.8e-07 28.6 0.0 0.017 14.5 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.1 AMD22534.1 - 1.7e-06 27.9 0.0 0.046 13.6 0.0 3.1 2 1 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 AMD22534.1 - 2.4e-06 27.4 10.6 0.00093 18.9 0.3 5.0 4 2 0 4 4 3 1 Archaeal ATPase AAA_17 PF13207.1 AMD22534.1 - 8.1e-06 26.6 4.5 0.053 14.3 0.0 3.8 4 1 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.18 AMD22534.1 - 3.7e-05 23.6 0.1 0.12 12.3 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC_tran PF00005.22 AMD22534.1 - 4.7e-05 23.6 1.0 0.46 10.7 0.0 3.7 3 1 0 3 3 3 1 ABC transporter DUF258 PF03193.11 AMD22534.1 - 5.6e-05 22.3 0.1 0.034 13.3 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 NACHT PF05729.7 AMD22534.1 - 5.9e-05 22.7 0.0 0.06 13.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.1 AMD22534.1 - 0.00016 22.0 8.8 0.056 13.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain MobB PF03205.9 AMD22534.1 - 0.00018 21.2 0.0 0.3 10.7 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 AMD22534.1 - 0.00024 20.8 0.0 0.76 9.5 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain AAA_28 PF13521.1 AMD22534.1 - 0.00035 20.5 0.0 0.4 10.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 AMD22534.1 - 0.00036 19.9 0.0 0.12 11.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain PduV-EutP PF10662.4 AMD22534.1 - 0.00039 19.9 0.0 0.32 10.4 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 AMD22534.1 - 0.00049 20.2 0.0 1.1 9.5 0.0 3.0 3 0 0 3 3 2 1 RNA helicase UPF0079 PF02367.12 AMD22534.1 - 0.0011 18.5 0.0 0.72 9.4 0.0 2.7 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 AMD22534.1 - 0.0013 18.3 0.7 1.7 8.1 0.0 3.5 3 1 1 4 4 4 1 AAA domain Zeta_toxin PF06414.7 AMD22534.1 - 0.0015 17.7 0.0 0.027 13.5 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.16 AMD22534.1 - 0.0019 17.3 0.1 0.54 9.3 0.0 3.1 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 AMD22534.1 - 0.0021 17.0 3.2 0.49 9.2 0.2 3.7 2 2 0 2 2 2 1 Protein of unknown function (DUF815) ResIII PF04851.10 AMD22534.1 - 0.0028 17.4 0.3 1.9 8.2 0.0 3.8 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit SRP54 PF00448.17 AMD22534.1 - 0.0029 17.0 0.1 1.1 8.6 0.0 2.8 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.1 AMD22534.1 - 0.0035 16.7 0.0 3.6 6.9 0.0 3.0 3 0 0 3 3 2 0 AAA domain T2SE PF00437.15 AMD22534.1 - 0.0041 16.0 1.2 0.08 11.8 0.0 2.8 3 1 0 3 3 2 1 Type II/IV secretion system protein AAA_24 PF13479.1 AMD22534.1 - 0.0066 16.0 0.0 3.2 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 AMD22534.1 - 0.0096 15.3 0.1 0.62 9.4 0.0 3.0 2 1 1 3 3 3 1 AAA-like domain AAA_3 PF07726.6 AMD22534.1 - 0.013 15.0 0.2 0.27 10.8 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 AMD22534.1 - 0.014 14.6 0.0 1.4 8.1 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein Miro PF08477.8 AMD22534.1 - 0.017 15.5 0.3 0.57 10.6 0.0 2.9 3 0 0 3 3 2 0 Miro-like protein Torsin PF06309.6 AMD22534.1 - 0.032 14.1 0.0 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 Torsin AAA_33 PF13671.1 AMD22534.1 - 0.033 14.0 0.0 3.5 7.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 AMD22534.1 - 0.033 13.7 0.0 6.1 6.3 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein TrwB_AAD_bind PF10412.4 AMD22534.1 - 0.035 12.7 0.0 4.5 5.7 0.0 2.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain LacI PF00356.16 AMD22534.1 - 0.036 13.6 0.1 7.6 6.2 0.0 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family CbiA PF01656.18 AMD22534.1 - 0.052 12.9 0.5 1.5 8.2 0.0 2.8 3 0 0 3 3 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF641 PF04859.7 AMD22534.1 - 0.054 13.2 2.0 1.3 8.7 0.0 2.7 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF848 PF05852.6 AMD22534.1 - 0.1 12.4 6.2 0.3 10.9 4.3 1.8 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) AAA_6 PF12774.2 AMD22534.1 - 0.16 11.5 0.1 9.3 5.7 0.0 2.8 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region D1 NTPase_1 PF03266.10 AMD22534.1 - 0.29 10.8 5.3 13 5.4 0.0 3.9 4 0 0 4 4 4 0 NTPase bZIP_1 PF00170.16 AMD22535.1 - 8.2e-07 28.8 20.0 1.7e-05 24.7 13.9 2.4 1 1 0 1 1 1 1 bZIP transcription factor Phage_GP20 PF06810.6 AMD22535.1 - 0.0012 18.3 4.4 0.0025 17.2 3.0 1.5 1 0 0 1 1 1 1 Phage minor structural protein GP20 bZIP_Maf PF03131.12 AMD22535.1 - 0.16 12.3 14.8 0.045 14.0 6.3 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor Glutaredoxin2_C PF04399.8 AMD22535.1 - 0.22 11.1 1.3 0.37 10.3 0.9 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain bZIP_2 PF07716.10 AMD22535.1 - 5.8 6.8 20.6 7 6.5 4.8 2.4 1 1 1 2 2 2 0 Basic region leucine zipper WD40 PF00400.27 AMD22536.1 - 4.4e-84 273.6 37.2 7.8e-14 50.9 0.3 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat NLE PF08154.7 AMD22536.1 - 2.5e-09 37.0 0.0 4.5e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.6 AMD22536.1 - 1.6e-08 34.5 0.7 7.3e-05 22.5 0.0 3.4 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 AMD22536.1 - 1.7e-05 23.1 8.7 0.074 11.1 0.6 4.8 3 2 2 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 AMD22536.1 - 8.3e-05 21.5 0.8 0.069 11.8 0.1 3.4 2 1 0 2 2 2 1 Nup133 N terminal like Cytochrom_D1 PF02239.11 AMD22536.1 - 0.00015 20.2 0.0 0.1 10.8 0.1 2.8 2 1 1 3 3 3 2 Cytochrome D1 heme domain Gmad1 PF10647.4 AMD22536.1 - 0.0012 18.2 0.1 0.065 12.6 0.0 2.2 2 0 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain PD40 PF07676.7 AMD22536.1 - 0.0016 18.0 0.0 2.6 7.7 0.0 3.0 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.1 AMD22536.1 - 0.0024 17.0 1.4 0.22 10.5 0.1 3.0 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Lactamase_B PF00753.22 AMD22536.1 - 0.058 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily TFIIIC_delta PF12657.2 AMD22536.1 - 0.46 10.1 5.5 15 5.2 0.0 3.8 2 2 1 3 3 3 0 Transcription factor IIIC subunit delta N-term Pkinase PF00069.20 AMD22537.1 - 5.9e-63 212.4 0.0 1.2e-62 211.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22537.1 - 3.2e-32 111.6 0.0 5.5e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD22537.1 - 2.6e-05 23.3 0.0 0.00054 19.0 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Metallophos PF00149.23 AMD22538.1 - 8.6e-40 136.2 0.8 1.4e-39 135.6 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 AMD22538.1 - 0.0036 17.1 0.0 0.0049 16.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ubiquitin PF00240.18 AMD22539.1 - 6e-07 28.7 0.1 7e-07 28.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 AMD22539.1 - 0.00018 21.1 0.0 0.00019 21.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.5 AMD22539.1 - 0.026 15.0 0.1 0.029 14.9 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.1 AMD22539.1 - 0.059 13.6 0.2 0.36 11.1 0.1 2.0 1 1 0 1 1 1 0 Ubiquitin-like domain Chorismate_bind PF00425.13 AMD22540.1 - 2.2e-64 217.2 0.0 4.5e-64 216.2 0.0 1.5 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 AMD22540.1 - 1.4e-34 119.2 0.0 2.2e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 AMD22540.1 - 4.2e-13 49.5 0.0 1.1e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 AMD22540.1 - 1.8e-09 37.3 0.0 4e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 Glucosamine_iso PF01182.15 AMD22541.1 - 1.8e-49 168.1 0.0 1.7e-48 165.0 0.0 1.9 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PQ-loop PF04193.9 AMD22542.1 - 3.5e-19 68.1 8.6 1e-10 41.0 0.1 2.7 3 0 0 3 3 3 2 PQ loop repeat Kua-UEV1_localn PF10520.4 AMD22542.1 - 0.043 13.4 3.7 0.055 13.1 1.5 1.8 2 0 0 2 2 2 0 Kua-ubiquitin conjugating enzyme hybrid localisation domain MpPF26 PF07666.6 AMD22542.1 - 0.078 12.8 0.2 0.078 12.8 0.2 2.8 2 1 1 3 3 3 0 M penetrans paralogue family 26 LMBR1 PF04791.11 AMD22543.1 - 4.1e-15 55.3 17.0 9.5e-14 50.8 11.8 2.2 1 1 0 1 1 1 1 LMBR1-like membrane protein Fb_signal PF08341.6 AMD22543.1 - 0.048 13.6 0.1 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Fibronectin-binding protein signal sequence DUF3215 PF11503.3 AMD22544.1 - 6e-27 93.0 0.1 6.9e-27 92.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) PAT1 PF09770.4 AMD22546.1 - 2.8e-247 823.0 33.4 3.2e-247 822.8 23.2 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Vinculin PF01044.14 AMD22546.1 - 0.37 8.7 6.2 0.63 7.9 4.3 1.3 1 0 0 1 1 1 0 Vinculin family P34-Arc PF04045.9 AMD22547.1 - 5.7e-93 310.6 0.7 8.1e-93 310.1 0.5 1.2 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Ribosom_S12_S23 PF00164.20 AMD22548.1 - 2.5e-44 149.6 1.2 3e-44 149.3 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 PP2C PF00481.16 AMD22549.1 - 1.1e-30 106.9 0.0 1.5e-26 93.3 0.0 2.6 1 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 AMD22549.1 - 0.0006 19.2 0.0 0.0026 17.1 0.0 1.9 2 0 0 2 2 2 1 Protein phosphatase 2C Ribosomal_S19 PF00203.16 AMD22550.1 - 1.5e-21 75.8 0.0 2.1e-21 75.2 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S19 DEAD PF00270.24 AMD22551.1 - 2.2e-37 128.1 0.4 3.7e-37 127.3 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22551.1 - 8.4e-18 64.0 0.0 2.4e-17 62.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD22551.1 - 1.1e-08 35.1 0.0 1.1e-08 35.1 0.0 2.9 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 AMD22551.1 - 0.0004 20.1 0.9 0.0042 16.8 0.1 2.6 1 1 1 2 2 2 1 Flavivirus DEAD domain Med12 PF09497.5 AMD22552.1 - 1.4e-24 85.8 0.1 3e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Cation_efflux PF01545.16 AMD22553.1 - 9.5e-12 44.5 14.7 3.9e-11 42.5 10.1 2.0 2 1 0 2 2 2 1 Cation efflux family CCSMST1 PF15013.1 AMD22553.1 - 0.039 13.8 0.1 0.039 13.8 0.1 2.3 2 0 0 2 2 2 0 CCSMST1 family DUF4294 PF14127.1 AMD22554.1 - 0.061 12.9 0.9 0.082 12.5 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) UbiA PF01040.13 AMD22556.1 - 3.7e-32 111.5 16.2 4.7e-32 111.2 11.3 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family GHMP_kinases_N PF00288.21 AMD22557.1 - 3.9e-10 39.6 0.9 1.3e-09 37.9 0.6 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain Zn_clus PF00172.13 AMD22558.1 - 1.1e-08 34.8 8.7 1.6e-08 34.2 6.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.27 AMD22559.1 - 3.6e-62 204.1 14.4 2.1e-10 40.0 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.5 AMD22559.1 - 3.2e-30 104.1 12.1 4.9e-30 103.5 8.4 1.3 1 0 0 1 1 1 1 Tup N-terminal Nup160 PF11715.3 AMD22559.1 - 6.9e-07 27.7 2.3 0.14 10.2 0.1 4.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 AMD22559.1 - 0.0048 15.7 0.5 0.6 8.7 0.1 3.3 1 1 2 3 3 3 1 Nup133 N terminal like HDV_ag PF01517.13 AMD22559.1 - 0.085 12.5 0.0 0.2 11.3 0.0 1.5 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen NIT PF08376.5 AMD22559.1 - 0.11 11.9 5.2 0.16 11.4 3.6 1.2 1 0 0 1 1 1 0 Nitrate and nitrite sensing Csm1 PF12539.3 AMD22560.1 - 4.3e-33 113.6 0.0 7e-33 112.9 0.0 1.3 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 CENP-Q PF13094.1 AMD22560.1 - 0.0052 16.8 3.9 0.011 15.8 2.7 1.5 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Lebercilin PF15619.1 AMD22560.1 - 0.0063 15.9 5.0 0.0063 15.9 3.5 1.5 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Complex1_49kDa PF00346.14 AMD22560.1 - 0.0065 15.5 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit eIF3_subunit PF08597.5 AMD22560.1 - 0.0085 15.6 0.5 0.0098 15.4 0.3 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit PhoU PF01895.14 AMD22560.1 - 0.22 11.9 1.6 0.35 11.3 1.1 1.4 1 0 0 1 1 1 0 PhoU domain IncA PF04156.9 AMD22560.1 - 0.3 10.6 5.7 0.47 10.0 4.0 1.3 1 0 0 1 1 1 0 IncA protein Nup88 PF10168.4 AMD22560.1 - 0.9 7.2 4.0 1.2 6.9 2.8 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF16 PF01519.11 AMD22560.1 - 1.8 8.8 6.2 2.6 8.3 4.1 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF16 SlyX PF04102.7 AMD22560.1 - 1.8 9.0 5.1 3.6 8.0 3.4 1.7 1 1 0 1 1 1 0 SlyX zf-LYAR PF08790.6 AMD22561.1 - 3.4e-15 55.4 7.3 6.9e-15 54.4 5.0 1.5 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger Gar1 PF04410.9 AMD22561.1 - 0.046 13.1 1.6 0.077 12.4 1.1 1.4 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region zf-met PF12874.2 AMD22561.1 - 0.1 12.8 3.8 1.5 9.1 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type TraV PF09676.5 AMD22561.1 - 0.38 11.4 6.8 0.59 10.8 4.7 1.4 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) RNHCP PF12647.2 AMD22561.1 - 1.7 8.5 5.8 11 5.8 4.1 2.1 1 1 1 2 2 2 0 RNHCP domain COX6B PF02297.12 AMD22561.1 - 1.9 8.5 10.3 4.5 7.3 7.2 1.8 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb C1_4 PF07975.7 AMD22561.1 - 2.3 8.2 7.3 1.4 8.9 3.1 2.1 1 1 1 2 2 2 0 TFIIH C1-like domain zf-C2H2 PF00096.21 AMD22561.1 - 3 8.3 5.6 3.6 8.1 0.7 2.6 1 1 1 2 2 2 0 Zinc finger, C2H2 type A2L_zn_ribbon PF08792.5 AMD22561.1 - 9.1 5.8 7.8 7.9 6.0 1.4 2.7 1 1 1 2 2 2 0 A2L zinc ribbon domain Cofilin_ADF PF00241.15 AMD22562.1 - 2.9e-18 65.9 0.0 9.6e-18 64.2 0.0 1.9 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.23 AMD22562.1 - 8.4e-17 60.3 0.6 2e-16 59.1 0.4 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 AMD22562.1 - 7.2e-16 57.5 0.3 1.5e-15 56.4 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 AMD22562.1 - 2.3e-08 33.3 0.0 5.3e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Inhibitor_I53 PF11714.3 AMD22562.1 - 0.21 11.5 0.0 0.21 11.5 0.0 3.1 2 0 0 2 2 2 0 Thrombin inhibitor Madanin DUF866 PF05907.8 AMD22563.1 - 2.3e-22 79.2 10.9 1.1e-14 54.3 1.8 2.0 1 1 1 2 2 2 2 Eukaryotic protein of unknown function (DUF866) zf-BED PF02892.10 AMD22563.1 - 3.2 7.5 7.8 0.29 10.9 1.4 2.3 2 1 1 3 3 3 0 BED zinc finger Helicase_C PF00271.26 AMD22565.1 - 2.3e-12 46.5 0.0 4.8e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SUV3_C PF12513.3 AMD22565.1 - 1.9e-10 40.0 0.5 4.6e-10 38.7 0.3 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal DEAD PF00270.24 AMD22565.1 - 0.0019 17.7 0.0 0.0071 15.8 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AdoMet_MTase PF07757.8 AMD22566.1 - 2.3e-41 140.4 0.1 3.8e-41 139.7 0.1 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.1 AMD22566.1 - 0.054 13.0 0.0 0.18 11.3 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.1 AMD22566.1 - 0.1 12.2 0.0 5.6 6.6 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_23 PF13489.1 AMD22566.1 - 0.15 11.7 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.20 AMD22567.1 - 2.8e-75 252.8 0.0 3.2e-75 252.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22567.1 - 1.1e-36 126.2 0.0 1.5e-36 125.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD22567.1 - 3.8e-06 26.0 0.1 5.6e-06 25.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 AMD22567.1 - 0.0075 16.0 0.0 0.16 11.7 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family ApbA_C PF08546.6 AMD22569.1 - 4.4e-05 23.4 0.0 7.5e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal OmpH PF03938.9 AMD22569.1 - 0.04 13.8 5.5 0.11 12.3 2.2 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) APG6 PF04111.7 AMD22569.1 - 0.043 12.8 8.9 0.093 11.7 6.2 1.5 1 0 0 1 1 1 0 Autophagy protein Apg6 VitK2_biosynth PF02621.9 AMD22569.1 - 0.14 11.3 2.2 0.31 10.1 1.5 1.5 1 0 0 1 1 1 0 Menaquinone biosynthesis DUF342 PF03961.8 AMD22569.1 - 7.3 4.8 7.1 12 4.1 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) NAC PF01849.13 AMD22570.1 - 1.3e-17 63.0 0.2 2.4e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 NAC domain Glyco_hydro_20b PF02838.10 AMD22570.1 - 0.027 14.9 0.2 0.042 14.3 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 zf-C2H2_4 PF13894.1 AMD22571.1 - 2.7e-10 39.8 3.3 0.00035 20.6 0.0 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 AMD22571.1 - 2e-08 34.0 8.3 0.00065 19.8 1.3 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD22571.1 - 0.00058 20.0 7.3 0.1 12.9 0.5 3.5 3 1 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.2 AMD22571.1 - 0.0012 19.0 0.6 0.37 11.0 0.0 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD22571.1 - 0.017 15.2 2.9 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 AMD22571.1 - 0.038 14.2 0.3 0.038 14.2 0.2 3.0 3 1 0 3 3 3 0 C2H2-type zinc-finger domain LexA_DNA_bind PF01726.11 AMD22571.1 - 0.047 13.2 0.1 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain GAGA PF09237.6 AMD22571.1 - 0.069 12.7 0.3 0.26 10.9 0.1 2.0 2 0 0 2 2 2 0 GAGA factor Pox_A12 PF04651.8 AMD22571.1 - 0.088 12.9 0.8 0.1 12.7 0.6 1.2 1 0 0 1 1 1 0 Poxvirus A12 protein OrfB_Zn_ribbon PF07282.6 AMD22571.1 - 1.1 8.9 4.0 2.2 8.0 0.5 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zf-C2H2_6 PF13912.1 AMD22571.1 - 6.5 6.7 6.7 7.3 6.6 0.3 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger tRNA-synt_1 PF00133.17 AMD22573.1 - 2.7e-155 517.7 0.1 3.8e-155 517.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 AMD22573.1 - 4.4e-23 81.5 2.5 1.3e-13 50.3 0.0 3.7 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 AMD22573.1 - 1.4e-18 67.1 0.1 3.4e-18 65.8 0.1 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.1 AMD22573.1 - 0.00039 19.7 0.0 0.00099 18.4 0.0 1.6 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 zf-FPG_IleRS PF06827.9 AMD22573.1 - 0.004 16.7 3.3 0.0099 15.5 2.3 1.7 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS FLILHELTA PF10306.4 AMD22574.1 - 2.3e-17 62.7 0.0 4.2e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA Pkinase PF00069.20 AMD22575.1 - 7.1e-57 192.5 0.2 6.4e-55 186.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22575.1 - 9.5e-29 100.2 0.0 4.6e-27 94.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase RRM_1 PF00076.17 AMD22576.1 - 4.6e-59 195.9 0.9 4.5e-17 61.4 0.0 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22576.1 - 1.6e-49 165.7 0.4 7.7e-15 54.6 0.0 5.2 5 0 0 5 5 5 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22576.1 - 4.1e-19 68.1 0.4 4.6e-08 32.7 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-N PF05238.8 AMD22577.1 - 1.2e-67 228.7 0.0 1.5e-67 228.4 0.0 1.1 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Vps16_C PF04840.7 AMD22578.1 - 5.7e-76 255.4 5.8 1e-75 254.6 4.0 1.3 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.8 AMD22578.1 - 8.4e-61 205.7 0.0 1.5e-60 204.9 0.0 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region DUF1272 PF06906.6 AMD22578.1 - 0.12 12.2 0.1 0.28 11.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Skp1_POZ PF03931.10 AMD22579.1 - 4.2e-14 52.3 0.1 9e-14 51.3 0.0 1.5 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.26 AMD22579.1 - 0.0089 16.0 0.1 0.018 15.0 0.0 1.6 1 1 0 1 1 1 1 BTB/POZ domain zf-RING_UBOX PF13445.1 AMD22580.1 - 1.9e-13 49.8 4.1 5.9e-13 48.3 2.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger CLTH PF10607.4 AMD22580.1 - 5.1e-09 35.9 4.5 8.3e-08 32.0 0.6 2.9 2 1 0 2 2 2 2 CTLH/CRA C-terminal to LisH motif domain zf-RING_2 PF13639.1 AMD22580.1 - 0.012 15.4 2.6 0.027 14.2 1.8 1.7 1 0 0 1 1 1 0 Ring finger domain Flagellin_N PF00669.15 AMD22580.1 - 0.084 12.6 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region zf-RING_5 PF14634.1 AMD22580.1 - 0.09 12.5 2.3 0.28 10.9 1.6 1.8 1 0 0 1 1 1 0 zinc-RING finger domain Sgf11 PF08209.6 AMD22581.1 - 1.5e-17 62.5 3.6 2.1e-17 62.1 2.5 1.2 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) Catalase PF00199.14 AMD22582.1 - 9.7e-172 570.9 0.5 1.3e-171 570.5 0.4 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 AMD22582.1 - 1.5e-12 47.2 0.1 6.9e-12 45.0 0.0 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive GST_C PF00043.20 AMD22583.1 - 2.5e-08 33.7 0.2 4.2e-08 33.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 AMD22583.1 - 1.5e-05 25.0 0.0 5.7e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 AMD22583.1 - 0.0012 19.0 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Cytochrom_C_2 PF01322.15 AMD22583.1 - 0.017 15.6 0.1 0.026 15.0 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C' GST_C_2 PF13410.1 AMD22583.1 - 0.029 14.2 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Anp1 PF03452.9 AMD22585.1 - 3.7e-108 360.7 0.1 4.5e-108 360.4 0.1 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.21 AMD22585.1 - 0.0031 17.1 0.0 0.0062 16.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Alk_phosphatase PF00245.15 AMD22586.1 - 5.8e-110 367.8 0.1 6.9e-110 367.6 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 AMD22586.1 - 0.025 13.9 0.0 0.096 12.0 0.0 2.0 3 0 0 3 3 3 0 Metalloenzyme superfamily Arf PF00025.16 AMD22587.1 - 1.2e-43 148.3 0.1 1.6e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 AMD22587.1 - 8.8e-13 47.9 0.0 1.1e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22587.1 - 2.5e-12 47.3 0.0 3.8e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 AMD22587.1 - 9e-11 41.0 0.6 4.6e-05 22.2 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 AMD22587.1 - 5.8e-09 35.4 0.0 7.5e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 AMD22587.1 - 3.6e-08 33.0 0.0 4.2e-07 29.5 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD22587.1 - 1.3e-06 28.3 0.0 2.4e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 AMD22587.1 - 3.2e-06 26.4 0.0 3.9e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 AMD22587.1 - 0.079 13.1 0.1 0.82 9.8 0.1 2.4 1 1 0 1 1 1 0 AAA domain GIT_SHD PF08518.6 AMD22588.1 - 1.7e-21 75.2 0.6 3e-10 39.2 0.1 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Pentapeptide_4 PF13599.1 AMD22588.1 - 9.9e-10 38.0 3.2 0.00013 21.7 0.1 4.1 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) Herpes_BLRF2 PF05812.7 AMD22588.1 - 6.7 6.5 20.9 0.72 9.6 2.5 4.1 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein Ribonucleas_3_3 PF14622.1 AMD22589.1 - 2.3e-15 56.6 0.1 4.3e-15 55.8 0.1 1.4 1 1 0 1 1 1 1 Ribonuclease-III-like DEAD PF00270.24 AMD22590.1 - 3.2e-40 137.3 0.6 1e-39 135.7 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22590.1 - 3.1e-27 94.2 0.2 2.8e-26 91.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD22590.1 - 4.9e-05 23.2 0.0 4.9e-05 23.2 0.0 2.7 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 AMD22590.1 - 0.0013 18.8 0.4 0.0072 16.4 0.3 2.2 1 1 0 1 1 1 1 AAA domain ATP-synt_G PF04718.10 AMD22591.1 - 1.1e-30 106.2 0.4 1.3e-30 106.0 0.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit MCM PF00493.18 AMD22592.1 - 2.2e-140 467.2 0.1 3.1e-140 466.6 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 AMD22592.1 - 7.7e-24 84.5 0.3 7.7e-24 84.5 0.2 2.4 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.16 AMD22592.1 - 4.1e-06 26.1 0.0 0.00018 20.7 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 AMD22592.1 - 6.9e-06 25.8 0.0 4.1e-05 23.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 AMD22592.1 - 0.0009 18.8 0.0 0.01 15.4 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 AMD22592.1 - 0.062 12.7 0.5 3.4 7.1 0.0 3.3 4 0 0 4 4 4 0 Sigma-54 interaction domain RICTOR_V PF14668.1 AMD22593.1 - 0.078 12.9 0.3 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 DUF2207 PF09972.4 AMD22593.1 - 0.32 9.5 6.6 0.043 12.3 1.7 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) CAF1A PF12253.3 AMD22594.1 - 1.4e-20 73.1 15.7 1.4e-20 73.1 10.9 4.7 4 1 0 4 4 4 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.3 AMD22594.1 - 4e-18 65.5 78.5 4e-18 65.5 54.4 2.2 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal PspB PF06667.7 AMD22594.1 - 1.6 8.7 0.0 1.6 8.7 0.0 3.4 3 0 0 3 3 3 0 Phage shock protein B Mss4 PF04421.8 AMD22596.1 - 9.4e-11 41.4 0.3 2.8e-07 30.2 0.1 2.2 2 0 0 2 2 2 2 Mss4 protein eIF-6 PF01912.13 AMD22597.1 - 6.8e-85 283.1 1.5 8.4e-85 282.8 1.0 1.1 1 0 0 1 1 1 1 eIF-6 family RasGEF PF00617.14 AMD22598.1 - 2.9e-59 199.9 2.0 1.4e-58 197.7 0.1 2.4 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 AMD22598.1 - 1.9e-19 69.6 0.2 1.9e-19 69.6 0.1 3.1 3 0 0 3 3 3 1 RasGEF N-terminal motif SH3_9 PF14604.1 AMD22598.1 - 8.2e-13 47.7 0.6 1.3e-11 43.9 0.1 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 AMD22598.1 - 3e-11 42.5 0.0 7.8e-11 41.2 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 AMD22598.1 - 3.9e-06 26.2 0.1 1e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain GPS PF01825.16 AMD22598.1 - 8.3 6.6 8.5 21 5.3 0.2 4.0 4 0 0 4 4 4 0 Latrophilin/CL-1-like GPS domain CYSTM PF12734.2 AMD22599.1 - 0.00049 20.1 29.7 0.032 14.3 20.6 2.2 1 1 0 1 1 1 1 Cysteine-rich TM module stress tolerance VGLL4 PF15245.1 AMD22599.1 - 0.13 12.0 0.3 0.14 12.0 0.2 1.2 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 GRIP PF01465.15 AMD22600.1 - 1.3e-13 50.2 0.2 3.7e-13 48.7 0.1 1.9 1 0 0 1 1 1 1 GRIP domain IncA PF04156.9 AMD22600.1 - 6.3e-05 22.6 114.7 0.0012 18.5 10.2 7.3 2 2 3 5 5 4 3 IncA protein Tropomyosin_1 PF12718.2 AMD22600.1 - 7.1e-05 22.6 14.5 7.1e-05 22.6 10.1 7.1 2 2 4 6 6 6 3 Tropomyosin like Spc7 PF08317.6 AMD22600.1 - 0.0018 16.9 118.8 0.18 10.4 14.9 6.1 2 2 4 6 6 6 6 Spc7 kinetochore protein DUF1192 PF06698.6 AMD22600.1 - 0.0054 16.5 20.4 0.66 9.8 0.1 6.6 6 0 0 6 6 6 2 Protein of unknown function (DUF1192) AAA_13 PF13166.1 AMD22600.1 - 0.018 13.5 108.8 0.0064 15.0 22.1 4.7 2 2 2 4 4 4 0 AAA domain DUF869 PF05911.6 AMD22600.1 - 0.41 8.8 104.8 0.28 9.3 4.3 3.4 2 1 1 3 3 3 0 Plant protein of unknown function (DUF869) Myosin_tail_1 PF01576.14 AMD22600.1 - 1 7.0 118.6 0.028 12.1 37.8 4.2 1 1 2 3 3 3 0 Myosin tail Reo_sigmaC PF04582.7 AMD22600.1 - 1.4 8.0 61.2 0.094 11.8 3.7 6.8 2 2 4 6 6 6 0 Reovirus sigma C capsid protein ERM PF00769.14 AMD22600.1 - 2.9 7.3 107.6 0.52 9.7 11.5 6.4 1 1 6 7 7 7 0 Ezrin/radixin/moesin family CALCOCO1 PF07888.6 AMD22600.1 - 3.4 5.8 95.4 0.006 14.9 19.9 4.4 2 1 2 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin PF00261.15 AMD22600.1 - 3.7 6.5 112.8 0.069 12.2 7.1 6.1 2 2 2 4 4 4 0 Tropomyosin DUF1664 PF07889.7 AMD22600.1 - 7.2 6.4 66.2 0.19 11.5 5.3 7.8 3 3 4 8 8 8 0 Protein of unknown function (DUF1664) Polysacc_deac_1 PF01522.16 AMD22601.1 - 5e-25 87.5 0.0 8.4e-25 86.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase V_cholerae_RfbT PF05575.6 AMD22601.1 - 0.047 12.7 0.1 0.077 12.0 0.1 1.2 1 0 0 1 1 1 0 Vibrio cholerae RfbT protein UQ_con PF00179.21 AMD22603.1 - 8.6e-34 115.9 0.0 1.3e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 AMD22603.1 - 0.03 14.2 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.8 AMD22603.1 - 0.1 12.2 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 UEV domain PI3_PI4_kinase PF00454.22 AMD22605.1 - 3.3e-42 144.5 0.0 1.5e-41 142.4 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 AMD22605.1 - 4.8e-25 87.8 0.2 4.8e-25 87.8 0.1 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Spore_III_AE PF09546.5 AMD22605.1 - 0.002 17.1 0.8 0.0056 15.6 0.6 1.7 1 0 0 1 1 1 1 Stage III sporulation protein AE (spore_III_AE) Aconitase PF00330.15 AMD22606.1 - 3.5e-180 599.4 0.1 7.5e-180 598.3 0.1 1.5 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 AMD22606.1 - 4.8e-46 156.1 0.0 1.1e-45 154.9 0.0 1.7 2 0 0 2 2 2 1 Aconitase C-terminal domain tRNA-synt_2 PF00152.15 AMD22607.1 - 3.6e-85 285.6 0.4 6.4e-85 284.8 0.3 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AMD22607.1 - 1.9e-05 24.3 0.4 3.7e-05 23.5 0.3 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 AMD22607.1 - 0.055 12.6 0.8 0.43 9.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) zf-C2H2 PF00096.21 AMD22608.1 - 2e-08 34.1 14.9 0.00014 21.9 1.5 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22608.1 - 5.9e-07 29.3 9.1 0.003 17.7 1.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD22608.1 - 6.8e-06 26.1 8.6 7.4e-05 22.8 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.2 AMD22608.1 - 2.6e-05 24.2 5.8 0.0015 18.6 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD22608.1 - 0.00013 21.9 7.3 0.025 14.7 0.0 2.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 AMD22608.1 - 0.0089 15.9 2.9 2.9 7.9 0.4 2.6 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_2 PF12756.2 AMD22608.1 - 0.33 11.0 2.9 1.9 8.6 0.1 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) CHCH PF06747.8 AMD22609.1 - 0.012 15.5 0.3 0.022 14.6 0.2 1.5 1 1 0 1 1 1 0 CHCH domain Pet191_N PF10203.4 AMD22609.1 - 0.049 13.6 1.4 0.24 11.4 1.2 1.8 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 AMD22609.1 - 0.086 12.6 0.6 0.11 12.2 0.4 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like zf-C2H2 PF00096.21 AMD22610.1 - 1.4e-10 40.8 8.5 5.2e-05 23.3 0.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22610.1 - 5e-07 29.6 5.5 0.0023 18.1 0.0 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AMD22610.1 - 0.018 15.1 0.7 0.034 14.2 0.0 1.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 AMD22610.1 - 0.027 14.7 15.2 0.096 13.0 0.9 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.2 AMD22610.1 - 0.031 14.4 2.9 0.038 14.2 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-BED PF02892.10 AMD22610.1 - 0.76 9.5 7.7 87 2.9 5.4 2.4 1 1 0 1 1 1 0 BED zinc finger zf-C2H2_2 PF12756.2 AMD22610.1 - 1 9.5 5.2 0.58 10.2 0.2 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Pkinase PF00069.20 AMD22611.1 - 2.8e-50 170.8 0.0 7.7e-50 169.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22611.1 - 2.5e-20 72.6 0.0 1.4e-19 70.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 AMD22611.1 - 0.005 15.8 0.0 0.021 13.7 0.0 2.0 2 1 0 2 2 2 1 Kinase-like DUF1611 PF07755.6 AMD22611.1 - 0.14 10.8 0.0 0.22 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1611) Nucleoporin_FG PF13634.1 AMD22613.1 - 1.1e-17 64.3 81.8 4.5e-10 39.7 24.0 3.0 2 1 1 3 3 3 2 Nucleoporin FG repeat region Tweety PF04906.8 AMD22613.1 - 0.00098 17.6 0.3 0.00098 17.6 0.2 2.9 4 0 0 4 4 4 1 Tweety DUF2363 PF10155.4 AMD22613.1 - 0.055 13.3 1.9 2.4 8.1 0.3 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2363) DUF1664 PF07889.7 AMD22613.1 - 0.17 11.7 2.6 4 7.2 0.4 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.9 AMD22613.1 - 2.5 7.6 10.2 1.2 8.7 5.1 1.8 1 1 1 2 2 2 0 IncA protein XRN_N PF03159.13 AMD22614.1 - 6.4e-99 330.1 0.1 6.4e-99 330.1 0.1 1.8 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus Bud13 PF09736.4 AMD22615.1 - 1e-25 90.6 6.4 1e-25 90.6 4.4 3.2 2 2 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex Flu_M2 PF00599.12 AMD22616.1 - 0.025 14.3 0.3 0.061 13.1 0.0 1.8 2 0 0 2 2 2 0 Influenza Matrix protein (M2) SAE2 PF08573.5 AMD22616.1 - 0.34 11.6 4.4 2.6 8.8 0.5 2.9 1 1 1 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Mito_carr PF00153.22 AMD22617.1 - 7.8e-76 249.8 0.6 4.4e-26 90.4 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 AMD22617.1 - 0.0078 16.3 0.2 0.32 11.1 0.1 3.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 AMD22617.1 - 0.056 13.0 0.7 0.35 10.5 0.2 2.6 2 0 0 2 2 2 0 EF-hand domain pair zf-C2H2 PF00096.21 AMD22618.1 - 1.5e-11 43.9 8.9 1.2e-05 25.3 1.4 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22618.1 - 5.8e-09 35.6 6.5 0.00026 21.0 0.2 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD22618.1 - 2.4e-07 30.6 7.2 0.029 14.6 0.1 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-met PF12874.2 AMD22618.1 - 4.4e-05 23.5 5.2 0.01 16.0 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-BED PF02892.10 AMD22618.1 - 0.036 13.8 7.3 0.52 10.1 1.7 2.2 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_6 PF13912.1 AMD22618.1 - 0.17 11.8 0.4 5.2 7.1 0.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_5 PF13909.1 AMD22618.1 - 3 8.2 10.3 0.91 9.8 1.4 2.6 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.21 AMD22619.1 - 1.4e-07 31.4 9.8 0.00012 22.2 0.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22619.1 - 1.4e-06 28.2 7.5 0.00077 19.6 0.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AMD22619.1 - 1.8e-06 27.9 7.5 0.009 16.2 0.5 3.5 3 0 0 3 3 3 2 Zinc-finger double domain DUF1644 PF07800.7 AMD22619.1 - 0.00037 20.4 4.6 0.00045 20.1 3.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1644) zf-met PF12874.2 AMD22619.1 - 0.003 17.7 1.9 0.038 14.2 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type FMN_red PF03358.10 AMD22620.1 - 1.2e-05 24.8 0.1 1.7e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 AMD22620.1 - 4e-05 23.6 0.0 9.3e-05 22.4 0.0 1.6 2 1 0 2 2 2 1 Flavodoxin Flavodoxin_2 PF02525.12 AMD22620.1 - 0.039 13.4 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin-like fold Bacteriocin_IIc PF10439.4 AMD22620.1 - 0.71 10.0 5.5 0.92 9.6 1.1 2.2 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide MRG PF05712.8 AMD22621.1 - 6e-48 162.3 0.1 1.4e-47 161.1 0.0 1.5 2 0 0 2 2 2 1 MRG Tudor-knot PF11717.3 AMD22621.1 - 2.1e-06 27.3 0.3 4.4e-06 26.2 0.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Pkinase PF00069.20 AMD22622.1 - 1.5e-27 96.3 0.1 3.5e-27 95.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22622.1 - 4.9e-10 38.9 0.0 7e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AMD22622.1 - 0.029 14.0 0.0 0.89 9.2 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF3354 PF11834.3 AMD22622.1 - 0.032 13.8 0.0 0.065 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3354) Imm43 PF15602.1 AMD22625.1 - 0.31 10.9 2.6 4.6 7.1 0.1 2.2 1 1 1 2 2 2 0 Immunity protein 43 tRNA-synt_1 PF00133.17 AMD22626.1 - 1.6e-228 759.5 0.1 2.8e-228 758.8 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 AMD22626.1 - 8e-26 90.6 0.5 3.1e-25 88.7 0.1 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 AMD22626.1 - 3.6e-19 68.6 2.6 1.3e-07 30.6 0.7 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 AMD22626.1 - 0.00012 21.3 0.4 0.0014 17.7 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain HSP70 PF00012.15 AMD22627.1 - 3.8e-271 900.2 7.3 4.4e-271 900.1 5.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 AMD22627.1 - 1.1e-16 60.3 0.0 1.1e-15 57.0 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 AMD22627.1 - 0.0003 20.4 0.0 0.00068 19.3 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 AMD22627.1 - 0.019 13.7 0.9 0.31 9.8 0.2 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 AMD22627.1 - 0.043 12.9 0.1 0.39 9.7 0.0 2.5 1 1 1 2 2 2 0 Hydantoinase/oxoprolinase AAR2 PF05282.6 AMD22628.1 - 1.5e-63 214.9 6.0 1.8e-63 214.6 4.1 1.0 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S8e PF01201.17 AMD22629.1 - 2.5e-51 173.2 2.4 2.9e-51 173.0 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e zf-CSL PF05207.8 AMD22630.1 - 3.2e-24 84.2 1.5 4e-24 83.8 1.1 1.1 1 0 0 1 1 1 1 CSL zinc finger zf-H2C2_2 PF13465.1 AMD22630.1 - 0.34 11.2 2.1 2.7 8.4 0.4 2.1 2 0 0 2 2 2 0 Zinc-finger double domain ADH_zinc_N_2 PF13602.1 AMD22631.1 - 3.7e-12 47.2 0.0 7.1e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AMD22631.1 - 0.00044 19.9 0.2 0.00083 19.0 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PI3K_1B_p101 PF10486.4 AMD22631.1 - 0.53 7.8 1.8 0.74 7.3 1.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit YL1 PF05764.8 AMD22631.1 - 5.2 6.6 7.4 7.9 6.0 5.2 1.2 1 0 0 1 1 1 0 YL1 nuclear protein UQ_con PF00179.21 AMD22632.1 - 5.5e-29 100.3 0.1 1.1e-28 99.3 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 AMD22632.1 - 0.029 14.2 0.1 0.065 13.1 0.1 1.6 1 0 0 1 1 1 0 RWD domain EMP24_GP25L PF01105.19 AMD22632.1 - 0.044 13.4 0.1 0.057 13.1 0.1 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD CDI PF02234.14 AMD22632.1 - 0.71 9.7 3.8 0.46 10.3 0.7 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor Pribosyltran_N PF13793.1 AMD22633.1 - 7.4e-45 151.4 0.5 3.5e-42 142.8 0.0 2.5 2 1 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 AMD22633.1 - 9.1e-36 123.3 2.5 3.6e-29 101.8 1.5 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 AMD22633.1 - 2.1e-11 43.6 0.9 4.1e-11 42.6 0.0 1.9 3 0 0 3 3 3 1 Phosphoribosyl transferase domain UPRTase PF14681.1 AMD22633.1 - 0.0092 15.2 0.1 0.015 14.4 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase UCH PF00443.24 AMD22634.1 - 1.8e-70 237.1 4.4 9e-70 234.8 3.1 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD22634.1 - 1.4e-25 90.3 20.8 4.3e-22 78.9 0.3 3.4 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase RanGAP1_C PF07834.6 AMD22634.1 - 0.032 13.6 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 RanGAP1 C-terminal domain Fungal_trans PF04082.13 AMD22635.1 - 6.9e-23 80.8 2.5 1.5e-22 79.7 1.7 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD22635.1 - 1.8e-09 37.3 10.9 3.1e-09 36.5 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AhpC-TSA PF00578.16 AMD22636.1 - 1.9e-31 108.3 0.0 2.6e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.4 AMD22636.1 - 1.1e-14 53.7 0.2 2e-14 52.9 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.5 AMD22636.1 - 3e-09 36.5 0.0 4.4e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Redoxin Kinesin PF00225.18 AMD22637.1 - 2.1e-106 355.4 3.1 2.1e-106 355.4 2.1 2.6 2 1 0 2 2 2 1 Kinesin motor domain FlaC_arch PF05377.6 AMD22637.1 - 0.33 10.8 0.0 0.33 10.8 0.0 5.9 6 2 1 7 7 7 0 Flagella accessory protein C (FlaC) Sel1 PF08238.7 AMD22638.1 - 1.2e-44 149.7 11.6 1.4e-08 35.0 0.4 7.8 7 0 0 7 7 7 7 Sel1 repeat Rad51 PF08423.6 AMD22639.1 - 7e-139 460.9 0.0 1e-138 460.4 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 AMD22639.1 - 6.9e-14 51.6 0.0 1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 AMD22639.1 - 1.2e-12 47.8 0.2 3e-12 46.5 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.16 AMD22639.1 - 3.6e-11 42.7 0.0 5e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 AMD22639.1 - 4.4e-06 25.9 0.0 7.5e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.1 AMD22639.1 - 0.012 15.7 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.10 AMD22639.1 - 0.028 13.3 0.0 0.051 12.4 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain HHH PF00633.18 AMD22639.1 - 0.044 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif Sec7 PF01369.15 AMD22640.1 - 1.8e-23 83.1 1.0 3.5e-23 82.2 0.7 1.3 1 0 0 1 1 1 1 Sec7 domain FAM183 PF14886.1 AMD22640.1 - 0.029 14.9 0.1 0.08 13.4 0.0 1.7 1 0 0 1 1 1 0 FAM183A and FAM183B related Proteasome PF00227.21 AMD22641.1 - 8e-39 132.8 0.0 9.6e-39 132.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Cmc1 PF08583.5 AMD22642.1 - 1.5e-15 56.7 12.5 2.5e-15 55.9 8.7 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 AMD22642.1 - 0.0069 16.2 3.1 0.59 10.1 0.2 2.3 2 0 0 2 2 2 2 CHCH domain Ndufs5 PF10200.4 AMD22642.1 - 2.2 8.3 7.5 3.5 7.6 4.3 1.8 1 1 1 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF1358 PF07096.6 AMD22643.1 - 0.019 14.6 0.6 0.044 13.4 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1358) RICTOR_N PF14664.1 AMD22644.1 - 2.5e-94 315.9 15.1 3.2e-94 315.5 8.6 2.4 2 1 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.1 AMD22644.1 - 3.3e-76 255.2 0.4 3.3e-76 255.2 0.3 4.8 6 0 0 6 6 6 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.1 AMD22644.1 - 1.9e-26 91.7 0.0 2.2e-25 88.3 0.0 2.9 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.1 AMD22644.1 - 6.6e-25 87.2 3.6 3.9e-23 81.5 0.1 4.4 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Corona_NS4 PF03905.8 AMD22644.1 - 0.078 12.7 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Coronavirus non-structural protein NS4 HEAT PF02985.17 AMD22644.1 - 0.17 12.0 1.5 32 4.9 0.0 4.6 5 0 0 5 5 5 0 HEAT repeat Meth_synt_2 PF01717.13 AMD22646.1 - 6.5e-142 472.2 0.0 6.7e-135 449.2 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 AMD22646.1 - 1.9e-120 401.8 0.3 2.5e-100 335.7 0.0 4.1 4 0 0 4 4 4 4 Cobalamin-independent synthase, N-terminal domain SEP PF08059.8 AMD22647.1 - 2.2e-23 82.3 0.2 2.2e-23 82.3 0.2 2.1 3 0 0 3 3 3 1 SEP domain UBX PF00789.15 AMD22647.1 - 4.8e-15 55.3 0.1 9.4e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 AMD22647.1 - 8.7e-12 44.3 0.5 1.9e-11 43.2 0.3 1.6 1 0 0 1 1 1 1 UBA-like domain PTH2 PF01981.11 AMD22648.1 - 1e-41 141.2 0.0 1.6e-41 140.5 0.0 1.3 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Sigma70_r4 PF04545.11 AMD22648.1 - 0.13 11.6 0.2 0.28 10.5 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Imm12 PF15589.1 AMD22648.1 - 0.13 12.0 0.2 1 9.1 0.0 2.1 2 1 0 2 2 2 0 Immunity protein 12 Chorismate_bind PF00425.13 AMD22649.1 - 1.5e-89 299.7 0.0 3.1e-89 298.6 0.0 1.5 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 AMD22649.1 - 2.1e-27 95.8 0.0 6.2e-24 84.5 0.0 2.8 3 0 0 3 3 3 2 Anthranilate synthase component I, N terminal region PP2C PF00481.16 AMD22650.1 - 5.2e-79 265.2 0.0 6.6e-79 264.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C TatD_DNase PF01026.16 AMD22651.1 - 3.1e-38 131.4 0.0 9.9e-38 129.7 0.0 1.7 1 1 0 1 1 1 1 TatD related DNase DUF2087 PF09860.4 AMD22651.1 - 0.0097 15.6 0.0 7.3 6.4 0.0 2.8 3 0 0 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2087) Myb_DNA-bind_6 PF13921.1 AMD22652.1 - 7.6e-12 45.1 1.4 5.4e-10 39.2 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 AMD22652.1 - 6.2e-07 29.3 4.0 1.8e-06 27.8 0.2 2.6 2 1 0 2 2 2 1 Myb-like DNA-binding domain MOZ_SAS PF01853.13 AMD22653.1 - 7.6e-77 256.8 1.3 1.4e-76 255.9 0.9 1.4 1 0 0 1 1 1 1 MOZ/SAS family RRM_6 PF14259.1 AMD22654.1 - 1.9e-07 30.9 0.0 3.5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 AMD22654.1 - 5.7e-07 29.0 0.1 1.2e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22654.1 - 0.00015 21.4 0.0 0.00028 20.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TMEM51 PF15345.1 AMD22654.1 - 0.04 13.6 9.0 0.1 12.2 6.2 1.7 1 0 0 1 1 1 0 Transmembrane protein 51 RRM_2 PF04059.7 AMD22654.1 - 0.065 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif 2 zf-C4H2 PF10146.4 AMD22654.1 - 0.53 10.2 7.2 0.57 10.1 3.0 2.4 3 0 0 3 3 3 0 Zinc finger-containing protein Band_3_cyto PF07565.8 AMD22654.1 - 0.61 9.5 8.4 0.049 13.1 2.1 1.8 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Brr6_like_C_C PF10104.4 AMD22655.1 - 4.4e-36 123.3 0.2 5.1e-36 123.1 0.2 1.0 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain RAI1 PF08652.6 AMD22656.1 - 5.3e-28 96.5 0.2 1.1e-27 95.5 0.1 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Smoothelin PF12510.3 AMD22656.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein tRNA-synt_1c PF00749.16 AMD22657.1 - 7.2e-114 379.6 0.0 9.7e-114 379.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 AMD22657.1 - 3.4e-39 134.3 0.1 7.2e-39 133.2 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_2 PF13410.1 AMD22657.1 - 4.2e-05 23.3 0.0 0.00011 22.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 AMD22657.1 - 8.2e-05 23.0 0.0 0.00031 21.1 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 AMD22657.1 - 0.0046 16.9 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF155 PF02582.9 AMD22658.1 - 6.7e-59 198.7 0.0 1.2e-58 197.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Plus-3 PF03126.13 AMD22659.1 - 1.4e-33 115.1 0.1 1.4e-33 115.1 0.1 2.8 3 0 0 3 3 3 1 Plus-3 domain A_deamin PF02137.13 AMD22660.1 - 1.5e-60 205.3 0.1 1.9e-60 205.0 0.1 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Ank_2 PF12796.2 AMD22661.1 - 1.9e-09 37.7 0.0 2.5e-06 27.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 AMD22661.1 - 1.1e-08 34.3 0.0 0.00093 18.8 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 AMD22661.1 - 2.4e-08 33.9 0.0 3.4e-05 23.9 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 AMD22661.1 - 1e-07 32.2 0.3 0.0012 19.2 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 AMD22661.1 - 2e-05 24.3 0.2 0.029 14.6 0.0 3.7 3 1 0 3 3 3 1 Ankyrin repeat IBN_N PF03810.14 AMD22662.1 - 9.1e-06 25.5 0.0 0.00014 21.7 0.0 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.7 AMD22662.1 - 0.2 11.5 0.1 0.2 11.5 0.0 5.2 5 2 0 5 5 5 0 Exportin 1-like protein XPC-binding PF09280.6 AMD22662.1 - 0.29 10.6 2.5 7.4 6.1 0.0 3.6 3 0 0 3 3 3 0 XPC-binding domain QRPTase_C PF01729.14 AMD22664.1 - 2e-56 190.1 0.0 2.6e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 AMD22664.1 - 9.9e-22 76.5 0.0 2.8e-21 75.1 0.0 1.8 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain APC10 PF03256.11 AMD22665.1 - 6.8e-57 192.2 0.0 8.2e-57 191.9 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.20 AMD22665.1 - 9.7e-05 22.2 0.1 0.00024 20.9 0.0 1.7 2 1 0 2 2 2 1 F5/8 type C domain Cse1 PF08506.5 AMD22666.1 - 1.7e-167 556.6 8.8 3.4e-167 555.6 6.1 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.10 AMD22666.1 - 6.3e-110 367.4 4.7 6.3e-110 367.4 3.3 2.0 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.14 AMD22666.1 - 9e-15 54.3 0.4 2.7e-13 49.6 0.0 3.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 AMD22666.1 - 0.023 14.9 0.0 0.89 9.8 0.0 3.6 5 1 0 5 5 5 0 HEAT repeats Xpo1 PF08389.7 AMD22666.1 - 0.33 10.8 0.0 0.33 10.8 0.0 4.7 6 2 1 7 7 7 0 Exportin 1-like protein CBFB_NFYA PF02045.10 AMD22667.1 - 4e-28 97.7 7.8 9.1e-28 96.5 5.4 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B GIDA PF01134.17 AMD22669.1 - 1.6e-157 524.3 0.0 2.1e-157 524.0 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 AMD22669.1 - 1.8e-19 69.5 0.1 6.6e-19 67.7 0.0 2.0 2 0 0 2 2 2 1 GidA associated domain 3 Pyr_redox_2 PF07992.9 AMD22669.1 - 1.3e-06 28.4 0.2 2.7e-06 27.4 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 AMD22669.1 - 3.6e-05 23.0 0.4 8.5e-05 21.8 0.3 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 AMD22669.1 - 0.0028 16.6 4.0 0.21 10.4 0.0 2.9 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AMD22669.1 - 0.068 11.9 6.4 0.026 13.3 2.5 1.7 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.22 AMD22669.1 - 0.1 12.9 0.4 0.24 11.8 0.3 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 AMD22669.1 - 0.29 9.5 2.9 7.1 4.9 1.3 2.3 2 0 0 2 2 2 0 HI0933-like protein GARS_A PF01071.14 AMD22670.1 - 4.9e-81 270.9 0.0 9.1e-81 270.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 AMD22670.1 - 1.5e-34 118.4 0.5 1.1e-33 115.6 0.0 2.7 4 0 0 4 4 3 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.17 AMD22670.1 - 6.7e-33 113.8 0.0 8.2e-32 110.3 0.0 2.3 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.11 AMD22670.1 - 8.2e-27 93.2 0.1 2.1e-26 91.8 0.1 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.19 AMD22670.1 - 9.7e-17 61.0 4.0 4.7e-16 58.8 1.6 2.9 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain ATP-grasp_4 PF13535.1 AMD22670.1 - 5.4e-11 42.5 0.0 3.3e-10 39.9 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 AMD22670.1 - 1.9e-09 36.7 0.0 4.3e-09 35.5 0.0 1.5 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 AMD22670.1 - 4.3e-07 29.4 0.0 8.5e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 AMD22670.1 - 1.8e-06 27.4 0.0 3.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.9 AMD22670.1 - 7.9e-06 25.8 0.1 2.5e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.5 AMD22670.1 - 0.013 14.8 0.0 0.035 13.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.8 AMD22670.1 - 0.075 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus RimK PF08443.6 AMD22670.1 - 0.12 11.7 0.0 0.32 10.4 0.0 1.7 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Mito_carr PF00153.22 AMD22671.1 - 1.5e-43 146.3 1.8 3.8e-19 68.1 0.0 4.6 3 2 0 3 3 3 3 Mitochondrial carrier protein Peptidase_M20 PF01546.23 AMD22672.1 - 3.5e-26 91.8 0.0 5.4e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 AMD22672.1 - 1.3e-11 44.2 0.0 2.5e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Sec15 PF04091.7 AMD22673.1 - 2.9e-106 355.3 13.8 2.9e-106 355.3 9.6 2.4 3 0 0 3 3 3 1 Exocyst complex subunit Sec15-like THUMP PF02926.12 AMD22674.1 - 6e-22 78.0 0.8 1.2e-21 77.1 0.3 1.8 1 1 0 1 1 1 1 THUMP domain DUF1077 PF06417.7 AMD22675.1 - 4.5e-46 155.2 3.6 5.7e-46 154.9 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Adaptin_binding PF10199.4 AMD22676.1 - 0.0081 16.4 0.7 0.081 13.2 0.1 1.9 1 1 1 2 2 2 1 Alpha and gamma adaptin binding protein p34 DUF1442 PF07279.6 AMD22676.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1442) COX6A PF02046.10 AMD22677.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIa DnaJ PF00226.26 AMD22678.1 - 2.2e-13 49.7 1.3 1.8e-12 46.7 1.5 2.1 3 0 0 3 3 3 1 DnaJ domain SAPS PF04499.10 AMD22679.1 - 2.2e-166 554.2 8.2 1.6e-165 551.3 3.4 2.2 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein DUF651 PF04895.7 AMD22680.1 - 0.14 11.7 2.0 1.2 8.7 0.0 3.3 3 1 0 4 4 4 0 Archaeal protein of unknown function (DUF651) AdoHcyase PF05221.12 AMD22681.1 - 9.6e-141 467.3 0.1 1.1e-140 467.1 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 AMD22681.1 - 4.2e-86 286.8 3.2 6.6e-86 286.1 2.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 AMD22681.1 - 2.6e-06 26.6 0.1 5.2e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 AMD22681.1 - 0.00021 20.6 0.2 0.00037 19.9 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 AMD22681.1 - 0.00033 20.6 0.1 0.00072 19.5 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.16 AMD22681.1 - 0.047 13.2 0.1 0.083 12.4 0.1 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase SPRY PF00622.23 AMD22682.1 - 3.2e-20 72.4 0.0 9e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.4 AMD22682.1 - 1.1e-10 41.3 2.2 2.1e-10 40.4 1.6 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 AMD22682.1 - 0.06 13.1 0.0 0.15 11.8 0.0 1.8 1 0 0 1 1 1 0 LisH YtpI PF14007.1 AMD22683.1 - 0.019 14.8 0.4 0.023 14.5 0.2 1.2 1 0 0 1 1 1 0 YtpI-like protein Grp1_Fun34_YaaH PF01184.14 AMD22683.1 - 0.066 12.4 2.1 0.089 12.0 1.5 1.3 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family DUF2207 PF09972.4 AMD22683.1 - 0.15 10.5 0.9 0.17 10.4 0.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) COX4 PF02936.9 AMD22684.1 - 4.9e-11 42.5 0.1 6.6e-11 42.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Peptidase_M49 PF03571.10 AMD22684.1 - 0.093 10.7 0.0 0.13 10.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M49 PMSR PF01625.16 AMD22685.1 - 3.8e-49 166.5 0.2 4.9e-49 166.2 0.1 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase XPG_I PF00867.13 AMD22686.1 - 2e-22 79.0 0.0 5e-22 77.7 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 AMD22686.1 - 2.6e-05 24.3 0.0 0.0001 22.4 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain GATA PF00320.22 AMD22687.1 - 3.8e-16 58.1 1.7 8.9e-16 56.9 1.2 1.7 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 AMD22687.1 - 0.093 12.0 0.4 0.19 11.0 0.3 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Pilus_PilP PF11356.3 AMD22687.1 - 0.1 12.8 0.1 0.1 12.8 0.1 2.5 3 0 0 3 3 3 0 Type IV pilus biogenesis Img2 PF05046.9 AMD22688.1 - 1.8e-22 79.3 0.1 3.3e-22 78.5 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Glyco_transf_22 PF03901.12 AMD22689.1 - 7.1e-35 120.8 11.5 9.4e-35 120.4 8.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family cobW PF02492.14 AMD22690.1 - 1.6e-41 141.6 0.1 2.5e-41 141.0 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 AMD22690.1 - 0.00063 19.2 0.0 0.0021 17.5 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.1 AMD22690.1 - 0.0039 17.5 0.2 0.0099 16.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain GTP_EFTU PF00009.22 AMD22690.1 - 0.0059 16.0 0.0 3.1 7.1 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MobB PF03205.9 AMD22690.1 - 0.0072 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 AMD22690.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.1 AMD22690.1 - 0.012 15.8 1.1 0.047 13.9 0.3 2.4 2 1 0 2 2 2 0 AAA domain CobW_C PF07683.9 AMD22690.1 - 0.043 13.5 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain MMR_HSR1 PF01926.18 AMD22690.1 - 0.067 13.1 0.1 0.17 11.8 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 AMD22690.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 AMD22690.1 - 0.11 12.6 0.2 0.65 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 AMD22690.1 - 0.12 12.3 0.0 0.35 10.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 AMD22690.1 - 0.12 11.9 0.2 0.44 10.1 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Pro_isomerase PF00160.16 AMD22691.1 - 8.5e-29 100.7 0.1 1.5e-28 99.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lipase_3 PF01764.20 AMD22692.1 - 4.2e-08 32.9 0.0 8.2e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Phos_pyr_kin PF08543.7 AMD22693.1 - 1.3e-09 37.6 0.0 1.7e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 AMD22693.1 - 0.065 12.3 0.0 0.28 10.2 0.0 1.9 2 0 0 2 2 2 0 pfkB family carbohydrate kinase WD40 PF00400.27 AMD22694.1 - 1.2e-07 31.3 0.1 0.00024 20.8 0.0 4.0 5 0 0 5 5 5 2 WD domain, G-beta repeat zf-C3HC4_2 PF13923.1 AMD22695.1 - 3.2e-10 39.8 13.1 4.2e-10 39.4 6.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD22695.1 - 7.8e-10 38.2 12.4 2.7e-09 36.5 5.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 AMD22695.1 - 2e-08 33.8 3.9 2e-08 33.8 2.7 2.0 2 0 0 2 2 1 1 zf-RING of BARD1-type protein SAP PF02037.22 AMD22695.1 - 2.9e-08 33.0 0.0 9.1e-08 31.4 0.0 1.9 1 0 0 1 1 1 1 SAP domain zf-C3HC4_3 PF13920.1 AMD22695.1 - 7.9e-08 31.8 9.4 2.1e-07 30.5 3.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD22695.1 - 1e-07 31.5 11.8 1.6e-06 27.6 5.4 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 AMD22695.1 - 1.4e-07 31.2 16.5 3.8e-07 29.8 6.8 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 AMD22695.1 - 2.7e-07 30.2 11.4 6.1e-07 29.1 5.4 2.4 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 AMD22695.1 - 3.2e-05 23.9 7.0 7.7e-05 22.7 2.9 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 AMD22695.1 - 4.7e-05 23.0 4.5 4.7e-05 23.0 3.1 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-Di19 PF05605.7 AMD22695.1 - 0.00034 20.6 1.5 0.01 15.9 0.0 2.6 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-Apc11 PF12861.2 AMD22695.1 - 0.0035 17.1 2.7 0.014 15.2 0.9 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 AMD22695.1 - 0.0086 15.6 7.3 0.016 14.7 1.2 2.6 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 AMD22695.1 - 0.014 14.9 8.0 0.046 13.2 2.4 2.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.10 AMD22695.1 - 0.031 14.2 0.0 0.28 11.1 0.0 2.3 2 0 0 2 2 2 0 U-box domain Prok-RING_4 PF14447.1 AMD22695.1 - 0.31 10.6 5.3 0.38 10.3 1.5 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.9 AMD22695.1 - 0.51 9.8 8.5 8.2 5.9 0.1 4.2 4 0 0 4 4 4 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.5 AMD22695.1 - 1.1 9.2 5.6 18 5.3 0.8 2.8 3 0 0 3 3 3 0 Zinc ribbon domain zf-MIZ PF02891.15 AMD22695.1 - 5 6.7 9.2 24 4.5 4.4 2.4 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Fork_head PF00250.13 AMD22696.1 - 5.5e-34 116.0 0.4 1.3e-33 114.9 0.1 1.8 2 0 0 2 2 2 1 Fork head domain G10 PF01125.12 AMD22697.1 - 4.7e-53 178.6 5.8 5.7e-53 178.3 4.0 1.0 1 0 0 1 1 1 1 G10 protein Ytp1 PF10355.4 AMD22698.1 - 2.4e-105 351.5 19.3 3.3e-105 351.1 11.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 AMD22698.1 - 1.3e-24 85.7 7.0 1.3e-24 85.7 4.8 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Glucan_synthase PF02364.10 AMD22699.1 - 1.1e-298 992.7 3.4 1.6e-298 992.2 2.4 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 AMD22699.1 - 2.8e-29 101.4 0.1 8.3e-29 99.8 0.0 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 TPR_11 PF13414.1 AMD22700.1 - 6.3e-16 57.7 0.4 1e-15 57.1 0.3 1.3 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 AMD22700.1 - 1.6e-09 36.9 0.1 2.4e-05 23.9 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 AMD22700.1 - 2.8e-09 36.1 0.5 0.00011 21.6 0.6 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 AMD22700.1 - 0.00018 21.4 0.6 0.00094 19.1 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 AMD22700.1 - 0.00025 20.9 0.1 0.033 14.1 0.1 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 AMD22700.1 - 0.00025 20.5 0.1 0.0093 15.7 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 AMD22700.1 - 0.0011 19.0 0.1 0.0023 18.0 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 AMD22700.1 - 0.0015 18.1 0.4 0.1 12.4 0.1 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 AMD22700.1 - 0.0042 17.6 0.0 0.028 15.0 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 AMD22700.1 - 0.0058 16.9 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 AMD22700.1 - 0.01 16.5 0.0 0.023 15.3 0.0 1.5 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.13 AMD22700.1 - 0.016 15.0 1.2 0.18 11.7 0.1 2.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_9 PF13371.1 AMD22700.1 - 0.023 14.5 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Phasin PF05597.6 AMD22700.1 - 0.077 12.7 0.2 0.1 12.3 0.2 1.2 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TPR_10 PF13374.1 AMD22700.1 - 0.1 12.5 0.0 0.58 10.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat UPF0029 PF01205.14 AMD22701.1 - 1.1e-29 102.2 0.1 1.9e-29 101.5 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 AMD22701.1 - 1.1e-09 38.1 0.7 2.6e-09 36.9 0.5 1.6 1 0 0 1 1 1 1 RWD domain MPP6 PF10175.4 AMD22702.1 - 0.00089 19.6 4.3 0.002 18.5 3.0 1.9 1 1 0 1 1 1 1 M-phase phosphoprotein 6 HEAT_PBS PF03130.11 AMD22703.1 - 0.21 12.1 0.1 0.7 10.5 0.0 2.0 1 0 0 1 1 1 0 PBS lyase HEAT-like repeat BAF1_ABF1 PF04684.8 AMD22703.1 - 3.5 6.3 14.4 5.3 5.7 10.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FCP1_C PF09309.5 AMD22703.1 - 6.8 5.9 9.9 0.21 10.8 2.2 1.8 2 0 0 2 2 2 0 FCP1, C-terminal Isochorismatase PF00857.15 AMD22704.1 - 2.9e-21 76.1 0.4 8.6e-21 74.6 0.3 1.8 1 1 0 1 1 1 1 Isochorismatase family Varsurf_PPLC PF03490.8 AMD22704.1 - 0.22 11.2 1.3 2.8 7.6 0.0 2.6 3 1 0 3 3 3 0 Variant-surface-glycoprotein phospholipase C Gly_transf_sug PF04488.10 AMD22705.1 - 2.2e-12 47.2 0.1 5.5e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif MCPVI PF02993.9 AMD22706.1 - 0.015 15.5 1.3 0.015 15.5 0.9 1.1 1 0 0 1 1 1 0 Minor capsid protein VI DUF2370 PF10176.4 AMD22706.1 - 0.019 14.2 3.3 0.023 14.0 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Toxin_64 PF15542.1 AMD22706.1 - 0.13 12.8 4.6 0.23 12.0 3.2 1.3 1 0 0 1 1 1 0 Putative toxin 64 APC_CDC26 PF10471.4 AMD22706.1 - 3.4 8.4 7.4 4.9 7.9 5.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 Zip PF02535.17 AMD22706.1 - 5.6 5.8 5.4 6 5.7 3.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ras PF00071.17 AMD22707.1 - 9.2e-51 171.4 0.0 1.1e-50 171.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22707.1 - 1.7e-20 73.7 0.1 3e-20 72.8 0.0 1.4 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 AMD22707.1 - 2.8e-09 36.4 0.1 3.5e-09 36.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 AMD22707.1 - 1.7e-07 30.8 0.1 3.4e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 AMD22707.1 - 0.0023 17.8 0.0 0.004 17.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 AMD22707.1 - 0.055 13.6 0.4 0.46 10.6 0.3 2.2 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.15 AMD22707.1 - 0.056 12.1 0.3 2.9 6.4 0.0 2.5 1 1 1 2 2 2 0 G-protein alpha subunit MRP-L28 PF09812.4 AMD22708.1 - 3e-34 118.0 4.0 3.8e-34 117.7 2.8 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 DUF413 PF04219.7 AMD22708.1 - 0.053 13.2 0.8 0.077 12.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF FYRC PF05965.9 AMD22708.1 - 0.07 12.9 0.7 0.59 9.9 0.1 2.1 1 1 1 2 2 2 0 F/Y rich C-terminus TPT PF03151.11 AMD22709.1 - 9.4e-37 126.0 12.9 9.4e-37 126.0 9.0 2.1 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 AMD22709.1 - 6.1e-15 54.9 16.9 7.7e-15 54.5 11.7 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 AMD22709.1 - 0.00013 22.0 28.2 0.0016 18.5 7.5 3.2 3 1 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.10 AMD22709.1 - 0.00016 20.8 9.0 0.034 13.2 1.8 2.4 2 1 0 2 2 2 2 Nucleotide-sugar transporter UPF0546 PF10639.4 AMD22709.1 - 0.081 12.7 9.4 0.95 9.2 1.6 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0546 COX14 PF14880.1 AMD22709.1 - 3.6 7.2 8.7 0.77 9.4 0.6 2.8 2 0 0 2 2 2 0 Cytochrome oxidase c assembly zf-H2C2_2 PF13465.1 AMD22710.1 - 3.2e-05 23.9 12.3 0.00091 19.4 0.4 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 AMD22710.1 - 0.00038 20.6 13.2 0.0011 19.1 1.2 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AMD22710.1 - 0.00059 19.9 16.3 0.014 15.6 0.7 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AMD22710.1 - 0.0075 16.3 9.7 0.3 11.2 0.5 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 AMD22710.1 - 0.076 12.9 1.0 2.3 8.2 0.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.10 AMD22710.1 - 0.23 11.2 9.9 0.062 13.0 1.0 3.1 3 0 0 3 3 3 0 BED zinc finger DUF3020 PF11223.3 AMD22711.1 - 1.4e-14 54.1 6.1 1.4e-14 54.1 4.2 8.7 8 2 0 8 8 8 1 Protein of unknown function (DUF3020) Toprim_3 PF13362.1 AMD22711.1 - 0.025 14.8 1.4 0.048 13.8 0.2 2.0 2 0 0 2 2 2 0 Toprim domain Sybindin PF04099.7 AMD22712.1 - 1.6e-38 131.6 0.8 1.1e-23 83.5 0.0 2.1 2 0 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.8 AMD22712.1 - 1.5e-09 37.8 0.7 5e-09 36.1 0.1 1.8 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region MTHFR PF02219.12 AMD22714.1 - 8.2e-105 350.0 0.0 1e-104 349.6 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ERCC4 PF02732.10 AMD22715.1 - 9.3e-23 80.5 0.1 1.4e-21 76.7 0.0 2.4 2 0 0 2 2 2 1 ERCC4 domain RFC1 PF08519.7 AMD22716.1 - 1.8e-56 190.2 0.6 4.3e-56 188.9 0.1 1.9 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.24 AMD22716.1 - 1.3e-11 44.8 0.4 9.7e-11 41.9 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.21 AMD22716.1 - 6.3e-10 39.0 0.0 1.9e-09 37.5 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.10 AMD22716.1 - 3.5e-08 32.6 0.3 9.9e-06 24.5 0.0 2.8 3 0 0 3 3 3 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 AMD22716.1 - 3.5e-05 23.9 0.0 0.0015 18.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD22716.1 - 7.6e-05 23.5 5.4 8.6e-05 23.3 0.0 3.5 4 1 0 4 4 3 1 AAA domain RuvB_N PF05496.7 AMD22716.1 - 8.3e-05 21.7 0.0 0.00017 20.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 AMD22716.1 - 0.00097 19.4 0.9 0.0047 17.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 AMD22716.1 - 0.0012 18.6 0.0 0.0032 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AMD22716.1 - 0.0012 18.8 0.0 0.017 15.1 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 AMD22716.1 - 0.0024 17.7 0.0 0.022 14.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 AMD22716.1 - 0.0044 16.7 0.0 0.012 15.3 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 AMD22716.1 - 0.011 15.9 0.1 0.04 14.0 0.0 2.1 2 0 0 2 2 1 0 RNA helicase PTCB-BRCT PF12738.2 AMD22716.1 - 0.015 15.0 0.2 0.078 12.8 0.0 2.3 2 0 0 2 2 2 0 twin BRCT domain NTPase_1 PF03266.10 AMD22716.1 - 0.024 14.3 0.0 0.1 12.2 0.0 2.2 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.1 AMD22716.1 - 0.045 13.7 0.1 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 AMD22716.1 - 0.1 12.3 0.0 0.36 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) GRAB PF10375.4 AMD22717.1 - 8.8e-07 28.3 2.0 2.4e-06 26.9 1.4 1.8 1 0 0 1 1 1 1 GRIP-related Arf-binding domain IncA PF04156.9 AMD22717.1 - 0.00013 21.6 59.6 0.04 13.5 19.6 3.2 1 1 2 3 3 3 2 IncA protein THOC7 PF05615.8 AMD22717.1 - 0.014 15.7 12.0 0.014 15.7 8.3 4.2 1 1 3 4 4 4 0 Tho complex subunit 7 TPR_MLP1_2 PF07926.7 AMD22717.1 - 0.016 14.9 12.4 0.016 14.9 8.6 4.3 2 2 0 3 3 3 0 TPR/MLP1/MLP2-like protein Reo_sigmaC PF04582.7 AMD22717.1 - 0.021 14.0 22.8 0.039 13.1 1.6 3.2 1 1 2 3 3 3 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 AMD22717.1 - 0.054 11.9 45.2 0.0032 16.0 22.4 2.6 1 1 2 3 3 3 0 AAA domain ATG16 PF08614.6 AMD22717.1 - 0.063 13.0 54.3 0.18 11.6 2.0 4.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) SAP PF02037.22 AMD22717.1 - 0.14 11.7 5.3 0.23 10.9 0.3 3.6 3 0 0 3 3 3 0 SAP domain GAS PF13851.1 AMD22717.1 - 1.1 8.3 54.6 6.2 5.9 16.3 3.5 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Filament PF00038.16 AMD22717.1 - 1.8 7.9 49.6 1.5 8.2 30.1 3.5 1 1 1 2 2 2 0 Intermediate filament protein Syntaxin-6_N PF09177.6 AMD22717.1 - 6.2 7.3 33.5 3.8 7.9 2.9 4.5 1 1 2 4 4 4 0 Syntaxin 6, N-terminal YqeY PF09424.5 AMD22718.1 - 1.7e-19 70.1 3.6 2e-19 69.8 2.5 1.1 1 0 0 1 1 1 1 Yqey-like protein YEATS PF03366.11 AMD22719.1 - 1.1e-23 82.6 0.1 1.9e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 YEATS family YEATS PF03366.11 AMD22720.1 - 9.8e-21 73.2 0.0 1.9e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 YEATS family WD40 PF00400.27 AMD22721.1 - 7.3e-38 127.1 22.4 1e-07 31.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 AMD22721.1 - 0.086 11.1 0.2 0.35 9.1 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain TRF PF08558.5 AMD22722.1 - 7.2e-64 215.3 0.1 1.1e-63 214.8 0.0 1.3 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 AMD22722.1 - 9.5e-07 28.7 0.2 2.7e-06 27.3 0.1 1.8 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 AMD22722.1 - 0.00055 19.9 0.1 0.0013 18.7 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Linker_histone PF00538.14 AMD22723.1 - 1.6e-21 76.1 0.0 1.6e-21 76.1 0.0 2.5 3 1 0 3 3 3 1 linker histone H1 and H5 family HC2 PF07382.6 AMD22723.1 - 0.0034 17.2 38.7 0.0034 17.2 26.8 2.0 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 Dynamin_N PF00350.18 AMD22724.1 - 2.2e-41 141.4 0.2 2.2e-41 141.4 0.1 2.1 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.15 AMD22724.1 - 5.1e-05 22.2 1.3 5.1e-05 22.2 0.9 2.5 2 1 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.18 AMD22724.1 - 7.1e-05 22.7 0.1 0.0022 17.9 0.1 2.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 AMD22724.1 - 0.0005 20.5 0.0 0.0015 19.0 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AKAP7_RIRII_bdg PF10470.4 AMD22724.1 - 0.042 13.6 0.2 0.29 10.9 0.0 2.5 2 0 0 2 2 2 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein AAA_16 PF13191.1 AMD22724.1 - 0.053 13.4 5.4 0.065 13.2 0.1 3.5 3 1 1 4 4 4 0 AAA ATPase domain RNA_pol_N PF01194.12 AMD22725.1 - 4.9e-29 100.1 0.5 5.5e-29 99.9 0.3 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.7 AMD22725.1 - 0.074 13.1 0.2 0.093 12.8 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) YhfH PF14149.1 AMD22725.1 - 0.08 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 YhfH-like protein WD40 PF00400.27 AMD22726.1 - 8e-05 22.3 11.3 0.0016 18.2 0.2 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat rve_2 PF13333.1 AMD22727.1 - 0.17 11.9 4.0 0.36 10.9 0.0 2.5 2 0 0 2 2 2 0 Integrase core domain NAPRTase PF04095.11 AMD22728.1 - 1.2e-63 214.7 0.0 1.5e-63 214.3 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family IBN_N PF03810.14 AMD22729.1 - 5.5e-18 64.6 0.1 2.6e-15 56.0 0.0 3.5 3 0 0 3 3 3 2 Importin-beta N-terminal domain GerPC PF10737.4 AMD22729.1 - 0.08 12.7 0.0 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 Spore germination protein GerPC Y_phosphatase PF00102.22 AMD22730.1 - 1.7e-57 194.5 0.6 5e-57 192.9 0.4 1.9 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 AMD22730.1 - 0.0094 16.2 0.0 0.029 14.6 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 AMD22730.1 - 0.023 14.2 0.1 0.24 10.9 0.0 2.5 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Ribonuclease_T2 PF00445.13 AMD22732.1 - 5.2e-36 124.0 0.0 7.1e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Ribosomal_S27e PF01667.12 AMD22733.1 - 1e-29 101.8 3.3 1.4e-29 101.3 2.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.16 AMD22733.1 - 2e-05 24.3 0.8 2.4e-05 24.1 0.6 1.1 1 0 0 1 1 1 1 IBR domain TF_Zn_Ribbon PF08271.7 AMD22733.1 - 0.05 12.9 3.8 0.074 12.3 2.6 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding zinc_ribbon_5 PF13719.1 AMD22733.1 - 0.13 11.9 1.3 6.2 6.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AMD22733.1 - 0.14 11.9 1.3 6.3 6.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain FYVE_2 PF02318.11 AMD22733.1 - 0.14 12.0 0.6 0.17 11.7 0.4 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger Rsm22 PF09243.5 AMD22734.1 - 8.4e-29 100.4 0.5 5.3e-11 42.0 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.1 AMD22734.1 - 0.00022 21.0 0.0 0.00088 19.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD22734.1 - 0.076 13.5 0.0 0.27 11.8 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain SRPRB PF09439.5 AMD22735.1 - 1.1e-54 184.4 0.7 1.3e-54 184.1 0.5 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 AMD22735.1 - 1.6e-11 44.1 0.1 2.6e-11 43.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 AMD22735.1 - 5.3e-11 42.0 0.0 7.3e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 AMD22735.1 - 1.1e-06 29.1 0.1 1.9e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 AMD22735.1 - 4.4e-06 26.0 0.1 6.1e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 AMD22735.1 - 6.5e-06 25.7 0.2 0.00065 19.1 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 AMD22735.1 - 0.00014 21.0 0.2 0.0002 20.6 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 AMD22735.1 - 0.0021 17.4 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Arch_ATPase PF01637.13 AMD22735.1 - 0.0056 16.4 0.3 0.028 14.1 0.2 2.0 1 1 0 1 1 1 1 Archaeal ATPase DUF258 PF03193.11 AMD22735.1 - 0.0065 15.6 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 AMD22735.1 - 0.009 16.0 3.3 0.029 14.3 2.3 1.9 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 AMD22735.1 - 0.015 14.7 0.1 0.25 10.7 0.1 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.22 AMD22735.1 - 0.046 14.0 0.5 0.11 12.7 0.4 2.0 1 1 0 1 1 1 0 ABC transporter Dynamin_N PF00350.18 AMD22735.1 - 0.046 13.5 3.6 1.6 8.5 0.5 2.6 1 1 1 3 3 3 0 Dynamin family DPM2 PF07297.7 AMD22736.1 - 2e-10 40.8 6.2 2.2e-10 40.6 4.3 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.7 AMD22736.1 - 0.012 15.2 7.8 0.013 15.1 5.4 1.0 1 0 0 1 1 1 0 PIG-P Oxidored_q4 PF00507.14 AMD22736.1 - 3.3 7.5 8.0 4.1 7.2 5.5 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Peptidase_M50 PF02163.17 AMD22736.1 - 7.5 5.4 6.7 10 5.0 4.6 1.3 1 0 0 1 1 1 0 Peptidase family M50 DUF3414 PF11894.3 AMD22737.1 - 0 1489.1 57.4 0 1488.9 39.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) Nsp1_C PF05064.8 AMD22738.1 - 9.7e-38 128.4 7.6 9.7e-38 128.4 5.3 2.0 1 1 1 2 2 2 1 Nsp1-like C-terminal region EzrA PF06160.7 AMD22738.1 - 0.0039 15.4 8.7 0.0061 14.8 6.0 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Muted PF14942.1 AMD22738.1 - 0.96 9.3 5.9 1.2 9.0 3.3 1.7 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein LRR_6 PF13516.1 AMD22739.1 - 3.5e-05 23.4 6.4 0.17 12.0 0.2 4.9 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.2 AMD22739.1 - 0.0018 17.8 7.9 1.1 8.9 0.0 4.3 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) DUF544 PF04424.8 AMD22739.1 - 0.41 10.4 3.9 3.2 7.5 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF544) RabGAP-TBC PF00566.13 AMD22741.1 - 5.5e-25 88.1 2.4 7.4e-25 87.6 1.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain His_Phos_1 PF00300.17 AMD22742.1 - 6.3e-42 143.3 0.0 8.5e-42 142.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Carb_kinase PF01256.12 AMD22743.1 - 3.5e-50 170.5 0.0 1.1e-49 168.9 0.0 1.7 1 1 0 1 1 1 1 Carbohydrate kinase NAD_binding_1 PF00175.16 AMD22744.1 - 7.9e-28 97.2 0.0 1.3e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 AMD22744.1 - 1.6e-23 82.6 0.0 2.8e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 AMD22744.1 - 1.4e-08 34.8 0.0 3e-06 27.2 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain DBR1 PF05011.8 AMD22745.1 - 4.8e-10 39.4 0.1 7.8e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 AMD22745.1 - 4.1e-08 32.8 0.1 7.1e-07 28.8 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FAD_binding_2 PF00890.19 AMD22746.1 - 1.3e-123 413.0 3.2 1.6e-123 412.6 2.2 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 AMD22746.1 - 3.8e-48 162.5 0.5 5.8e-48 161.9 0.4 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.17 AMD22746.1 - 2.7e-06 26.5 1.7 0.00097 18.0 0.9 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.9 AMD22746.1 - 3e-06 27.2 1.0 0.00015 21.7 0.2 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 AMD22746.1 - 2.9e-05 23.2 0.1 0.0021 17.2 0.0 2.7 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 AMD22746.1 - 7.4e-05 21.8 3.0 0.001 18.0 2.1 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 AMD22746.1 - 0.0021 17.1 1.1 0.0094 15.0 0.1 2.3 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.9 AMD22746.1 - 0.017 13.5 0.6 0.068 11.6 0.1 2.1 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.1 AMD22746.1 - 0.43 10.6 2.3 1.5 8.8 0.3 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Aa_trans PF01490.13 AMD22747.1 - 1.3e-95 320.2 30.7 1.6e-95 320.0 21.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AAA PF00004.24 AMD22748.1 - 1.5e-40 138.4 0.0 4.5e-40 136.9 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 AMD22748.1 - 5.7e-06 26.4 0.0 0.0009 19.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 AMD22748.1 - 2e-05 24.3 0.0 0.00011 21.9 0.0 2.3 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 AMD22748.1 - 0.00012 22.1 0.0 0.00038 20.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 AMD22748.1 - 0.00031 20.6 0.0 0.00064 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 AMD22748.1 - 0.00089 18.2 0.0 0.0017 17.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 AMD22748.1 - 0.00099 19.9 0.0 0.0036 18.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 AMD22748.1 - 0.0047 16.0 0.0 0.0081 15.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 AMD22748.1 - 0.0058 16.3 0.2 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 AMD22748.1 - 0.0086 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 AMD22748.1 - 0.013 14.6 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 AMD22748.1 - 0.016 15.0 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 AMD22748.1 - 0.022 14.4 0.0 4.5 6.8 0.0 2.5 1 1 1 2 2 2 0 Archaeal ATPase AAA_18 PF13238.1 AMD22748.1 - 0.022 15.0 0.0 0.059 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 AMD22748.1 - 0.024 14.5 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 AMD22748.1 - 0.029 14.5 0.0 0.068 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.12 AMD22748.1 - 0.029 13.7 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.6 AMD22748.1 - 0.033 13.7 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 AMD22748.1 - 0.04 13.9 0.0 0.084 12.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 AMD22748.1 - 0.044 12.9 0.0 0.11 11.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 AMD22748.1 - 0.046 12.4 0.0 0.076 11.7 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 AMD22748.1 - 0.079 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_pol_Rbc25 PF08292.7 AMD22749.1 - 6.3e-45 152.3 0.3 8.8e-45 151.8 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 AMD22749.1 - 5e-20 71.3 0.0 7.5e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 AMD22749.1 - 0.066 13.3 0.0 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 S1 RNA binding domain UPF0370 PF13980.1 AMD22749.1 - 0.26 11.1 1.9 2.9 7.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) LTV PF04180.9 AMD22750.1 - 5.5e-110 368.7 28.1 6.5e-110 368.5 19.5 1.0 1 0 0 1 1 1 1 Low temperature viability protein DUF3294 PF07957.6 AMD22751.1 - 5.6e-79 264.6 5.1 6.2e-79 264.5 3.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) FlaC_arch PF05377.6 AMD22751.1 - 0.0082 16.0 2.3 3.1 7.7 0.0 3.4 2 1 1 3 3 3 2 Flagella accessory protein C (FlaC) CRF-BP PF05428.6 AMD22751.1 - 0.013 14.3 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Corticotropin-releasing factor binding protein (CRF-BP) FKBP_N PF01346.13 AMD22751.1 - 0.018 15.0 3.2 0.068 13.2 0.8 2.2 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase HsbA PF12296.3 AMD22751.1 - 0.32 10.8 5.2 0.68 9.7 1.2 2.9 2 1 2 4 4 4 0 Hydrophobic surface binding protein A BLOC1_2 PF10046.4 AMD22751.1 - 0.7 10.0 5.2 1.9 8.6 0.3 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PUF PF00806.14 AMD22752.1 - 7.9e-27 91.2 12.4 0.00014 21.1 0.0 8.9 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat Cpn60_TCP1 PF00118.19 AMD22753.1 - 8e-133 443.5 7.3 9.1e-133 443.3 5.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Vps53_N PF04100.7 AMD22754.1 - 1.5e-78 264.2 14.0 2.2e-78 263.7 9.7 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal Spc7_C2 PF15577.1 AMD22754.1 - 0.031 13.9 0.0 0.073 12.7 0.0 1.6 1 0 0 1 1 1 0 Spc7_C2 DUF3724 PF12521.3 AMD22754.1 - 0.1 12.3 0.1 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) HORMA PF02301.13 AMD22755.1 - 3.7e-46 157.2 0.5 4.2e-46 157.0 0.3 1.0 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.4 AMD22755.1 - 0.00017 21.0 0.2 0.0012 18.3 0.2 2.0 1 1 0 1 1 1 1 Autophagy-related protein 13 DUF3440 PF11922.3 AMD22755.1 - 0.042 13.4 0.1 0.059 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) SspB PF04386.8 AMD22755.1 - 0.095 12.3 1.4 0.23 11.0 0.1 2.0 1 1 2 3 3 3 0 Stringent starvation protein B PPTA PF01239.17 AMD22756.1 - 4.4e-41 136.5 14.8 2.6e-09 36.0 1.2 6.0 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Cyclin_N PF00134.18 AMD22757.1 - 1.4e-15 56.9 6.0 2.3e-14 53.0 1.6 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.14 AMD22757.1 - 0.0038 17.0 0.1 0.063 13.0 0.0 2.4 2 0 0 2 2 2 1 Transcription factor TFIIB repeat DEAD PF00270.24 AMD22758.1 - 3.3e-43 147.1 0.0 9.1e-43 145.6 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.1 AMD22758.1 - 1.3e-25 88.6 0.2 2.9e-25 87.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 AMD22758.1 - 7.8e-20 70.5 0.0 1.9e-19 69.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain FHA PF00498.21 AMD22759.1 - 4.6e-12 45.8 0.0 9.6e-12 44.8 0.0 1.7 1 1 0 1 1 1 1 FHA domain FKBP_N PF01346.13 AMD22759.1 - 0.014 15.4 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase HSP70 PF00012.15 AMD22760.1 - 3.7e-267 887.1 12.1 4.2e-267 886.9 8.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 AMD22760.1 - 2.1e-19 69.2 1.5 9e-18 63.9 0.2 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 AMD22760.1 - 5.5e-05 22.4 2.2 0.027 13.5 0.1 2.9 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase FGGY_C PF02782.11 AMD22760.1 - 0.0077 15.8 0.0 0.051 13.1 0.0 2.3 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 AMD22760.1 - 0.06 13.1 4.1 2.1 8.2 2.9 3.3 1 1 0 1 1 1 0 Cell division protein FtsA DUF1104 PF06518.6 AMD22760.1 - 9.5 6.4 12.7 28 4.9 4.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) Nramp PF01566.13 AMD22761.1 - 1.8e-89 300.0 18.6 2.4e-89 299.6 12.9 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein RNase_PH PF01138.16 AMD22763.1 - 6.4e-29 100.9 0.0 9.1e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 AMD22763.1 - 2.1e-05 24.3 0.2 4.9e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Mannosyl_trans PF05007.8 AMD22764.1 - 4.8e-79 265.6 26.0 4.8e-79 265.6 18.0 1.7 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 AMD22764.1 - 4.2e-11 42.3 24.0 1.1e-10 40.9 15.9 2.1 1 1 1 2 2 2 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 AMD22764.1 - 8.6e-08 31.9 9.2 1.4e-07 31.2 6.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2029) DUF4365 PF14280.1 AMD22765.1 - 0.054 13.2 0.5 0.058 13.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4365) CBF PF03914.12 AMD22766.1 - 6e-38 129.8 2.9 6.8e-38 129.6 0.1 2.4 3 0 0 3 3 3 1 CBF/Mak21 family NOC3p PF07540.6 AMD22766.1 - 1e-31 109.0 2.1 1e-31 109.0 1.5 3.4 3 0 0 3 3 3 1 Nucleolar complex-associated protein Ovate PF04844.8 AMD22766.1 - 0.0056 16.4 0.7 0.62 9.8 0.1 2.9 2 0 0 2 2 2 1 Transcriptional repressor, ovate Ssl1 PF04056.9 AMD22766.1 - 0.015 14.8 0.9 0.18 11.3 0.0 2.6 3 0 0 3 3 3 0 Ssl1-like GEMIN8 PF15348.1 AMD22766.1 - 1.1 9.2 19.8 0.33 10.9 6.5 2.8 2 1 1 3 3 3 0 Gemini of Cajal bodies-associated protein 8 FAM176 PF14851.1 AMD22766.1 - 4.9 6.8 9.7 0.84 9.3 2.4 2.5 2 0 0 2 2 2 0 FAM176 family Mpp10 PF04006.7 AMD22767.1 - 1.8e-125 419.6 51.2 2.5e-125 419.1 35.5 1.1 1 0 0 1 1 1 1 Mpp10 protein Aa_trans PF01490.13 AMD22768.1 - 3.6e-77 259.5 18.1 4.3e-77 259.3 12.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Fasciclin PF02469.17 AMD22769.1 - 2.2e-24 85.9 0.4 2.7e-06 27.3 0.0 6.0 5 2 0 5 5 5 5 Fasciclin domain Dynamin_M PF01031.15 AMD22770.1 - 1.2e-112 375.5 0.0 1.9e-112 374.9 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 AMD22770.1 - 1.5e-54 184.3 0.0 4.4e-54 182.8 0.0 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 AMD22770.1 - 1e-28 99.0 1.2 3.9e-28 97.1 0.8 2.1 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 AMD22770.1 - 0.00048 20.0 0.3 0.0076 16.2 0.2 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 AMD22770.1 - 0.019 15.4 0.0 0.08 13.4 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein KAT11 PF08214.6 AMD22771.1 - 1.5e-85 287.3 0.7 1.9e-85 287.0 0.5 1.1 1 0 0 1 1 1 1 Histone acetylation protein Proteasome PF00227.21 AMD22772.1 - 1.6e-48 164.4 0.7 1.9e-48 164.3 0.5 1.0 1 0 0 1 1 1 1 Proteasome subunit Pox_A51 PF04948.8 AMD22772.1 - 0.042 12.5 0.2 0.07 11.7 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A51 protein Sfi1 PF08457.5 AMD22773.1 - 2.5e-33 115.3 64.5 2.2e-29 102.3 36.3 2.4 1 1 1 2 2 2 2 Sfi1 spindle body protein Sfi1_C PF10638.4 AMD22773.1 - 1.9e-24 86.1 3.2 1.9e-24 86.1 2.2 2.1 2 0 0 2 2 2 1 Spindle body associated protein C-terminus Ribophorin_I PF04597.9 AMD22774.1 - 1.3e-123 412.7 2.7 1.5e-123 412.5 1.9 1.0 1 0 0 1 1 1 1 Ribophorin I ORC3_N PF07034.6 AMD22775.1 - 9.2e-08 31.4 1.4 5.6e-07 28.8 0.5 2.2 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus COX16 PF14138.1 AMD22776.1 - 1.7e-31 108.2 0.2 2.8e-31 107.5 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 bZIP_1 PF00170.16 AMD22776.1 - 0.027 14.4 2.9 0.049 13.5 0.0 2.1 2 0 0 2 2 2 0 bZIP transcription factor DUF2371 PF10177.4 AMD22776.1 - 0.034 14.0 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF221 PF02714.10 AMD22777.1 - 3.5e-89 298.8 22.6 3.5e-89 298.8 15.7 2.9 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 AMD22777.1 - 3.5e-29 101.3 3.4 3.5e-29 101.3 2.4 2.8 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 AMD22777.1 - 9.4e-07 28.6 0.0 2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Phosphate metabolism protein DUF2404 PF10296.4 AMD22778.1 - 1.6e-05 24.9 0.1 4.6e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) FerA PF08165.6 AMD22778.1 - 0.07 12.8 1.2 0.17 11.6 0.1 2.2 2 0 0 2 2 2 0 FerA (NUC095) domain DEAD PF00270.24 AMD22780.1 - 3.3e-45 153.6 0.1 9.1e-45 152.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22780.1 - 1.4e-26 92.0 0.2 5.2e-26 90.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 AMD22780.1 - 0.049 13.7 0.3 0.19 11.8 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 AMD22780.1 - 0.11 12.2 0.5 0.46 10.2 0.1 2.2 2 0 0 2 2 2 0 Part of AAA domain SYS1 PF09801.4 AMD22781.1 - 5.6e-49 165.8 14.5 6.6e-49 165.6 10.0 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network K_trans PF02705.11 AMD22781.1 - 0.0012 17.3 0.2 0.0015 16.9 0.1 1.1 1 0 0 1 1 1 1 K+ potassium transporter PP2C PF00481.16 AMD22782.1 - 1e-45 156.1 0.2 1.5e-45 155.5 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.1 AMD22782.1 - 3.1e-42 142.1 83.2 1e-09 38.0 3.8 10.0 6 3 2 9 9 9 7 Leucine rich repeat LRR_4 PF12799.2 AMD22782.1 - 5.3e-37 124.8 108.0 1.6e-07 30.7 0.4 13.9 6 3 7 14 14 14 10 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.15 AMD22782.1 - 1.2e-24 86.6 0.0 2.4e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 AMD22782.1 - 1.9e-12 45.3 92.5 0.15 12.2 0.2 19.9 19 1 0 19 19 19 8 Leucine Rich Repeat RA PF00788.18 AMD22782.1 - 9.2e-08 32.4 0.1 2.1e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PP2C_2 PF13672.1 AMD22782.1 - 0.07 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C LRR_7 PF13504.1 AMD22782.1 - 0.079 13.1 79.4 1.6 9.3 0.8 18.0 20 0 0 20 20 20 0 Leucine rich repeat LRR_9 PF14580.1 AMD22782.1 - 5.8 6.4 25.8 1.7 8.1 1.9 4.6 1 1 2 4 4 4 0 Leucine-rich repeat COX17 PF05051.8 AMD22783.1 - 4.1e-20 71.5 6.7 5.1e-20 71.2 4.7 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.8 AMD22783.1 - 0.00045 20.0 3.9 0.00064 19.5 2.7 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.5 AMD22783.1 - 0.043 13.5 5.3 0.16 11.8 0.0 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF1903 PF08991.5 AMD22783.1 - 0.4 10.8 9.0 1.1 9.4 3.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1903) PNP_UDP_1 PF01048.15 AMD22784.1 - 1.1e-31 109.5 0.0 1.4e-31 109.2 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily NPCC PF08058.6 AMD22785.1 - 1e-31 109.7 1.8 2.1e-31 108.7 1.3 1.5 1 0 0 1 1 1 1 Nuclear pore complex component NIF PF03031.13 AMD22786.1 - 3.1e-50 169.9 0.1 5.3e-50 169.1 0.1 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DNA_ligase_IV PF11411.3 AMD22786.1 - 0.019 14.7 0.7 0.051 13.3 0.5 1.8 1 0 0 1 1 1 0 DNA ligase IV WD40 PF00400.27 AMD22787.1 - 4.3e-35 118.3 6.8 7.9e-09 35.0 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat Sof1 PF04158.9 AMD22787.1 - 3.1e-28 97.6 13.4 6.6e-28 96.5 9.3 1.6 1 0 0 1 1 1 1 Sof1-like domain eIF2A PF08662.6 AMD22787.1 - 8.1e-05 22.4 2.8 0.09 12.4 0.2 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 AMD22787.1 - 0.0012 18.5 0.3 0.011 15.4 0.1 2.7 2 2 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region rRNA_processing PF08524.6 AMD22787.1 - 0.053 13.3 9.1 0.087 12.6 6.3 1.3 1 0 0 1 1 1 0 rRNA processing Abhydro_lipase PF04083.11 AMD22788.1 - 1.2e-15 56.5 0.0 2.4e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_6 PF12697.2 AMD22788.1 - 2.3e-06 27.6 0.0 3e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AMD22788.1 - 0.00052 19.6 0.2 0.0022 17.5 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Lipase_2 PF01674.13 AMD22788.1 - 0.00085 18.6 0.0 0.0017 17.6 0.0 1.6 1 1 0 1 1 1 1 Lipase (class 2) Abhydrolase_5 PF12695.2 AMD22788.1 - 0.0013 18.5 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 AMD22788.1 - 0.035 13.4 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.10 AMD22788.1 - 0.096 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase chaperone_DMP PF10448.4 AMD22789.1 - 1.4e-29 102.8 0.1 1.8e-29 102.4 0.1 1.2 1 0 0 1 1 1 1 20S proteasome chaperone SBDS_C PF09377.5 AMD22790.1 - 1.1e-35 122.0 1.0 2.6e-35 120.8 0.4 1.7 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.13 AMD22790.1 - 9e-32 108.7 0.3 1.4e-31 108.1 0.2 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein PUF PF00806.14 AMD22791.1 - 2.1e-53 174.8 11.2 5.8e-08 31.8 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat PAT1 PF09770.4 AMD22791.1 - 0.046 11.9 34.7 0.088 11.0 21.6 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Endonuc_Holl PF10107.4 AMD22791.1 - 0.86 9.2 8.5 1.2 8.7 5.0 1.9 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Rab5ip PF07019.7 AMD22792.1 - 5.8e-18 64.7 4.1 7.2e-18 64.4 2.8 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF383 PF04063.9 AMD22793.1 - 7.9e-73 244.1 1.2 2.5e-72 242.4 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.8 AMD22793.1 - 3.8e-23 80.8 1.0 9.3e-23 79.5 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF384) HEAT_2 PF13646.1 AMD22793.1 - 3.4e-05 24.0 0.0 0.0016 18.6 0.0 2.8 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.17 AMD22793.1 - 0.00015 21.5 0.3 1.5 9.1 0.0 3.9 4 0 0 4 4 4 2 HEAT repeat Adaptin_N PF01602.15 AMD22793.1 - 0.0032 15.8 2.6 0.3 9.3 1.4 2.5 2 1 1 3 3 3 2 Adaptin N terminal region Colicin_immun PF09204.5 AMD22793.1 - 0.0096 15.9 0.1 0.035 14.1 0.0 1.9 1 0 0 1 1 1 1 Bacterial self-protective colicin-like immunity Arm PF00514.18 AMD22793.1 - 0.066 13.0 0.3 1.5 8.8 0.0 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat TFIIF_alpha PF05793.7 AMD22794.1 - 3.5e-10 38.8 44.2 5.5e-09 34.9 0.5 3.3 2 2 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) tRNA-synt_1b PF00579.20 AMD22795.1 - 6.2e-75 252.0 0.0 8.1e-75 251.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) zf-UBR PF02207.15 AMD22796.1 - 1.8e-13 50.0 10.8 5.2e-13 48.5 7.5 1.9 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Methyltransf_19 PF04672.7 AMD22796.1 - 0.31 10.2 0.0 0.6 9.3 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl methyltransferase zf-UBR PF02207.15 AMD22797.1 - 3e-17 62.0 11.9 3e-17 62.0 8.2 2.2 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 AMD22797.1 - 8e-07 28.7 0.0 3.1e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.1 AMD22797.1 - 3.8e-05 23.4 0.5 3.8e-05 23.4 0.3 3.1 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 AMD22797.1 - 0.0051 16.8 1.0 0.0051 16.8 0.7 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD22797.1 - 0.0069 16.0 0.6 0.0069 16.0 0.4 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) UCR_UQCRX_QCR9 PF05365.7 AMD22798.1 - 5.7e-27 93.1 1.2 6.1e-27 93.0 0.9 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like zf-Tim10_DDP PF02953.10 AMD22799.1 - 5.8e-14 51.1 3.1 7.6e-14 50.7 2.2 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger GPAT_N PF14829.1 AMD22799.1 - 0.13 12.0 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal Clat_adaptor_s PF01217.15 AMD22800.1 - 2.4e-55 186.1 1.0 2.9e-55 185.8 0.7 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Symplekin_C PF12295.3 AMD22800.1 - 0.046 13.6 0.2 0.069 13.0 0.1 1.3 1 0 0 1 1 1 0 Symplekin tight junction protein C terminal DUF793 PF05633.6 AMD22800.1 - 0.05 12.3 0.0 0.063 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF793) CBP4 PF07960.6 AMD22801.1 - 4.8e-50 168.4 3.7 5.3e-50 168.3 2.6 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.1 AMD22801.1 - 0.00019 21.1 0.2 0.00041 20.0 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4574) Tmemb_161AB PF10268.4 AMD22801.1 - 0.015 13.8 0.0 0.015 13.8 0.0 1.2 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB DUF600 PF04634.7 AMD22801.1 - 0.026 14.5 0.1 0.059 13.3 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF600 Meckelin PF09773.4 AMD22801.1 - 0.035 11.8 1.8 0.045 11.5 1.2 1.0 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) AAA_13 PF13166.1 AMD22801.1 - 0.16 10.3 4.5 0.18 10.1 3.1 1.0 1 0 0 1 1 1 0 AAA domain Ly49 PF08391.5 AMD22801.1 - 0.35 11.0 1.8 2.5 8.2 0.0 2.1 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF3186 PF11382.3 AMD22801.1 - 0.37 9.8 0.0 0.37 9.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3186) Utp11 PF03998.8 AMD22801.1 - 2.5 7.8 11.1 6.3 6.5 7.7 1.5 1 1 0 1 1 1 0 Utp11 protein SE PF08491.5 AMD22802.1 - 3.4e-115 383.6 0.0 4.3e-115 383.2 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 AMD22802.1 - 3.4e-12 46.1 0.0 1.4e-11 44.0 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 AMD22802.1 - 1.6e-05 24.0 0.1 4.4e-05 22.5 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AMD22802.1 - 0.0018 18.2 0.0 0.0039 17.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 AMD22802.1 - 0.0024 18.2 0.1 0.0091 16.3 0.1 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 AMD22802.1 - 0.0033 17.0 0.1 0.0056 16.3 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.19 AMD22802.1 - 0.017 13.9 0.2 0.031 13.1 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.9 AMD22802.1 - 0.018 14.9 0.0 0.041 13.7 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 AMD22802.1 - 0.02 14.9 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.11 AMD22802.1 - 0.043 13.2 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 AMD22802.1 - 0.063 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_oxidored PF12831.2 AMD22802.1 - 0.087 11.8 0.2 0.18 10.8 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.12 AMD22802.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family RRN7 PF11781.3 AMD22803.1 - 8.2e-11 41.2 0.8 1.3e-10 40.6 0.5 1.3 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 LsmAD PF06741.8 AMD22804.1 - 6.6e-28 96.6 0.9 6.6e-28 96.6 0.7 2.1 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.1 AMD22804.1 - 2.4e-16 59.4 0.6 1.2e-15 57.1 0.1 2.5 2 0 0 2 2 2 1 Ataxin 2 SM domain Thi4 PF01946.12 AMD22806.1 - 1.6e-95 318.5 0.1 1.9e-95 318.3 0.1 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 AMD22806.1 - 7e-08 31.7 0.8 2.3e-07 30.0 0.3 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AMD22806.1 - 6.6e-07 29.2 0.6 1.3e-05 25.1 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 AMD22806.1 - 1.1e-05 24.4 1.8 0.00036 19.5 0.5 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.1 AMD22806.1 - 3e-05 23.8 0.2 0.00016 21.5 0.1 2.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 AMD22806.1 - 5.6e-05 22.2 0.4 9.8e-05 21.4 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 AMD22806.1 - 6.7e-05 22.8 0.0 0.0039 17.1 0.3 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 AMD22806.1 - 0.0003 20.9 0.0 0.00055 20.0 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 AMD22806.1 - 0.0013 17.8 0.1 0.0019 17.3 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 AMD22806.1 - 0.012 14.0 0.7 0.023 13.1 0.5 1.4 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.17 AMD22806.1 - 0.028 13.2 0.5 0.086 11.6 0.1 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.9 AMD22806.1 - 0.067 11.7 0.4 0.098 11.2 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Ribonuc_red_sm PF00268.16 AMD22807.1 - 1.3e-121 404.9 1.1 1.6e-121 404.6 0.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Yip1 PF04893.12 AMD22808.1 - 3.2e-08 33.2 18.1 9.4e-08 31.7 12.5 1.8 1 1 0 1 1 1 1 Yip1 domain MMR_HSR1 PF01926.18 AMD22809.1 - 3.1e-20 72.2 0.5 7.1e-20 71.0 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.16 AMD22809.1 - 1.2e-18 66.7 0.0 2.7e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 AMD22809.1 - 3.4e-13 49.1 0.0 5.7e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 AMD22809.1 - 3.7e-05 23.6 0.3 0.0096 15.7 0.0 2.4 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 AMD22809.1 - 7.6e-05 23.1 0.1 0.00029 21.3 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein AIG1 PF04548.11 AMD22809.1 - 0.00049 19.2 0.1 0.00082 18.5 0.1 1.3 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.5 AMD22809.1 - 0.0098 15.1 0.4 0.05 12.8 0.0 2.2 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MCM PF00493.18 AMD22809.1 - 0.015 14.1 0.0 0.032 13.0 0.0 1.5 1 0 0 1 1 1 0 MCM2/3/5 family Ras PF00071.17 AMD22809.1 - 0.042 13.2 0.5 0.9 8.9 0.0 2.3 2 0 0 2 2 2 0 Ras family tRNA-synt_1g PF09334.6 AMD22810.1 - 5.8e-108 361.0 0.1 7.5e-108 360.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 AMD22810.1 - 2.7e-22 78.5 0.1 3.1e-11 42.0 0.0 3.8 2 2 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 AMD22810.1 - 1.1e-08 34.5 0.0 0.00026 20.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 AMD22810.1 - 0.012 14.3 0.0 0.02 13.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Anticodon_1 PF08264.8 AMD22810.1 - 0.088 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA DNA_pol_E_B PF04042.11 AMD22811.1 - 1.8e-40 138.4 0.0 2.6e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B PS_Dcarbxylase PF02666.10 AMD22812.1 - 6.1e-55 185.6 0.0 9.6e-55 185.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 AMD22812.1 - 5.2e-19 67.8 1.5 1.9e-10 40.4 0.0 3.4 3 0 0 3 3 3 2 C2 domain MAP7 PF05672.6 AMD22813.1 - 0.076 12.3 20.6 0.092 12.1 14.3 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family YkyA PF10368.4 AMD22813.1 - 0.44 9.8 10.4 0.47 9.7 7.2 1.0 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF724 PF05266.9 AMD22813.1 - 2.4 7.7 9.9 2.8 7.5 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PV-1 PF06637.6 AMD22813.1 - 4 5.9 11.8 4.5 5.7 8.2 1.0 1 0 0 1 1 1 0 PV-1 protein (PLVAP) HSP20 PF00011.16 AMD22815.1 - 1.4e-13 50.5 0.0 1.9e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Peptidase_M1 PF01433.15 AMD22816.1 - 2.3e-142 474.7 0.7 3.6e-142 474.0 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 AMD22816.1 - 1.4e-85 287.4 0.7 1.4e-85 287.4 0.5 1.7 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 AMD22816.1 - 5.9e-20 71.6 0.3 2e-19 69.9 0.2 2.0 1 0 0 1 1 1 1 Peptidase MA superfamily HEAT_2 PF13646.1 AMD22816.1 - 0.077 13.2 0.0 2.8 8.2 0.0 2.8 2 1 1 3 3 3 0 HEAT repeats RNase_H2-Ydr279 PF09468.5 AMD22818.1 - 3.9e-48 164.1 0.1 4.5e-48 163.9 0.0 1.0 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) RED_C PF07807.6 AMD22818.1 - 0.093 12.9 0.3 0.21 11.8 0.2 1.5 1 0 0 1 1 1 0 RED-like protein C-terminal region RNase_PH PF01138.16 AMD22819.1 - 8.1e-20 71.4 0.0 1.2e-19 70.9 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 AMD22819.1 - 8.4e-12 44.8 0.2 3.9e-11 42.7 0.0 2.2 3 0 0 3 3 3 1 3' exoribonuclease family, domain 2 RRM_1 PF00076.17 AMD22820.1 - 5.5e-16 57.9 0.0 2.6e-15 55.8 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22820.1 - 4.2e-09 36.2 0.0 1.1e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Mem_trans PF03547.13 AMD22820.1 - 0.61 8.3 6.8 0.93 7.7 4.7 1.3 1 0 0 1 1 1 0 Membrane transport protein DUF4175 PF13779.1 AMD22820.1 - 1.5 6.4 65.4 2.8 5.5 45.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Macoilin PF09726.4 AMD22820.1 - 2.5 6.2 31.0 0.021 13.1 12.2 2.1 2 0 0 2 2 2 0 Transmembrane protein FLO_LFY PF01698.11 AMD22820.1 - 2.6 6.8 21.1 51 2.5 16.4 1.8 2 0 0 2 2 2 0 Floricaula / Leafy protein Utp14 PF04615.8 AMD22820.1 - 2.9 5.9 35.1 4.7 5.2 24.3 1.2 1 0 0 1 1 1 0 Utp14 protein RabGAP-TBC PF00566.13 AMD22822.1 - 4.3e-34 117.8 17.1 2.2e-30 105.7 5.7 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain PAPA-1 PF04795.7 AMD22823.1 - 5.4e-17 62.2 6.9 5.4e-17 62.2 4.8 2.6 2 1 2 4 4 4 1 PAPA-1-like conserved region DUF2924 PF11149.3 AMD22823.1 - 2.1 8.3 4.7 1.9 8.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) DUF4163 PF13739.1 AMD22823.1 - 3.9 8.3 6.8 0.38 11.5 0.2 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4163) LIM_bind PF01803.11 AMD22824.1 - 9.2e-53 178.8 2.3 9.2e-53 178.8 1.6 3.9 3 1 0 3 3 3 1 LIM-domain binding protein PRTP PF01366.13 AMD22824.1 - 0.0011 17.0 0.4 0.0019 16.3 0.3 1.3 1 0 0 1 1 1 1 Herpesvirus processing and transport protein GOLGA2L5 PF15070.1 AMD22824.1 - 5 5.4 13.3 7.9 4.8 0.1 2.1 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Uds1 PF15456.1 AMD22825.1 - 0.14 12.1 1.1 0.26 11.2 0.1 1.9 2 1 0 2 2 2 0 Up-regulated During Septation Neugrin PF06413.6 AMD22826.1 - 6.5e-09 35.9 0.6 1.2e-08 35.0 0.4 1.6 1 1 0 1 1 1 1 Neugrin Sigma70_r4 PF04545.11 AMD22826.1 - 0.00012 21.3 0.0 0.00024 20.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_11 PF08279.7 AMD22826.1 - 0.0035 16.9 0.0 0.0078 15.8 0.0 1.6 1 0 0 1 1 1 1 HTH domain Rota_NSP4 PF01452.11 AMD22826.1 - 0.41 9.9 2.1 0.5 9.6 0.2 1.8 2 0 0 2 2 2 0 Rotavirus non structural protein HTH_32 PF13565.1 AMD22826.1 - 0.79 10.5 4.4 0.84 10.4 0.0 2.6 2 2 0 2 2 2 0 Homeodomain-like domain HSP70 PF00012.15 AMD22827.1 - 3.5e-237 788.1 10.0 3.9e-237 787.9 6.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 AMD22827.1 - 8e-18 64.1 2.2 2.4e-16 59.2 0.6 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 AMD22827.1 - 0.00021 20.9 0.0 0.00038 20.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Flagellin_N PF00669.15 AMD22827.1 - 0.23 11.2 3.2 0.58 9.9 2.2 1.6 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region DUF2984 PF11203.3 AMD22827.1 - 0.33 11.0 4.4 0.46 10.6 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2984) KH_1 PF00013.24 AMD22828.1 - 4.6e-06 26.1 0.2 4.6e-05 22.9 0.0 2.4 2 0 0 2 2 2 1 KH domain KH_3 PF13014.1 AMD22828.1 - 0.00076 19.0 0.5 0.0021 17.6 0.1 2.0 2 0 0 2 2 2 1 KH domain DUF2179 PF10035.4 AMD22828.1 - 0.025 14.1 0.6 0.069 12.7 0.4 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) Y_phosphatase PF00102.22 AMD22829.1 - 1.7e-52 178.1 0.0 3.6e-52 177.0 0.0 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 AMD22829.1 - 8.3e-05 22.1 0.1 0.00024 20.7 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 AMD22829.1 - 0.015 15.3 0.0 0.05 13.6 0.0 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 AMD22829.1 - 0.044 14.0 0.0 0.1 12.8 0.0 1.6 1 1 0 1 1 1 0 Tyrosine phosphatase family DUF2697 PF10906.3 AMD22830.1 - 2.3e-24 85.1 0.8 2.7e-24 84.9 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2697) VID27 PF08553.5 AMD22831.1 - 3.2e-278 925.2 15.8 3.5e-278 925.1 11.0 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein ThiF PF00899.16 AMD22832.1 - 8.5e-41 138.9 0.0 1.7e-40 137.9 0.0 1.5 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 AMD22832.1 - 1.7e-21 75.6 0.4 4e-21 74.3 0.3 1.7 1 0 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 AMD22832.1 - 9.1e-10 38.8 0.0 1.7e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Shikimate_DH PF01488.15 AMD22832.1 - 0.00029 20.9 0.1 0.0017 18.4 0.0 2.2 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Herpes_BLRF2 PF05812.7 AMD22832.1 - 0.0044 16.8 0.1 0.0084 15.9 0.1 1.4 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein NAD_binding_7 PF13241.1 AMD22832.1 - 0.0053 16.9 0.0 0.015 15.5 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding WD40 PF00400.27 AMD22833.1 - 9.6e-06 25.2 11.4 0.0074 16.1 0.1 6.7 8 1 1 9 9 9 2 WD domain, G-beta repeat TruB-C_2 PF09157.6 AMD22833.1 - 0.18 11.6 0.0 0.56 10.0 0.0 1.8 1 0 0 1 1 1 0 Pseudouridine synthase II TruB, C-terminal Rad60-SLD PF11976.3 AMD22834.1 - 1.3e-23 82.4 0.5 5.1e-23 80.5 0.1 2.2 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 AMD22834.1 - 7.3e-07 28.4 0.0 2.4e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family RNA_pol_Rpb1_5 PF04998.12 AMD22835.1 - 1.7e-95 319.4 0.3 2.6e-95 318.8 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 AMD22835.1 - 1.1e-81 274.7 0.0 1.6e-81 274.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 AMD22835.1 - 1.3e-69 233.4 0.0 2.4e-69 232.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 AMD22835.1 - 2.3e-39 134.6 0.1 1.3e-38 132.1 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 AMD22835.1 - 3.2e-31 107.2 0.0 8.4e-31 105.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DUF2786 PF10979.3 AMD22835.1 - 0.054 13.2 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) DSS1_SEM1 PF05160.8 AMD22836.1 - 1.6e-18 66.2 14.6 1.8e-18 66.0 10.1 1.0 1 0 0 1 1 1 1 DSS1/SEM1 family Tropomyosin_1 PF12718.2 AMD22837.1 - 8.9e-44 148.8 43.7 1.1e-43 148.5 30.3 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.15 AMD22837.1 - 5.9e-06 25.5 41.3 9.9e-06 24.8 28.6 1.4 1 1 0 1 1 1 1 Tropomyosin CENP-F_leu_zip PF10473.4 AMD22837.1 - 6.2e-05 22.8 45.3 0.00047 20.0 5.5 2.3 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.1 AMD22837.1 - 7.4e-05 22.0 40.0 0.00011 21.4 27.7 1.3 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Mod_r PF07200.8 AMD22837.1 - 0.00017 21.5 32.5 0.00066 19.6 15.9 2.2 1 1 1 2 2 2 2 Modifier of rudimentary (Mod(r)) protein MscS_porin PF12795.2 AMD22837.1 - 0.00022 20.6 23.6 0.00022 20.6 16.4 2.0 1 1 1 2 2 2 1 Mechanosensitive ion channel porin domain Myosin_tail_1 PF01576.14 AMD22837.1 - 0.00051 17.9 40.3 0.0012 16.7 27.9 1.5 1 1 0 1 1 1 1 Myosin tail ATG16 PF08614.6 AMD22837.1 - 0.00055 19.8 37.2 0.023 14.5 10.8 2.1 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) ADIP PF11559.3 AMD22837.1 - 0.00081 19.3 36.4 0.13 12.2 10.6 2.7 1 1 2 3 3 3 3 Afadin- and alpha -actinin-Binding Laminin_II PF06009.7 AMD22837.1 - 0.0017 18.1 23.3 0.03 14.0 7.8 2.1 1 1 1 2 2 2 2 Laminin Domain II TMF_TATA_bd PF12325.3 AMD22837.1 - 0.0047 16.6 40.8 0.018 14.8 15.1 3.0 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.3 AMD22837.1 - 0.0055 16.0 12.5 0.0055 16.0 8.7 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) TBPIP PF07106.8 AMD22837.1 - 0.0056 16.2 37.0 0.024 14.1 13.3 2.3 1 1 1 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_DNA_bd PF12329.3 AMD22837.1 - 0.0077 16.0 21.6 0.0077 16.0 14.9 3.2 1 1 2 3 3 3 1 TATA element modulatory factor 1 DNA binding MbeD_MobD PF04899.7 AMD22837.1 - 0.013 15.4 14.4 0.02 14.7 1.0 3.1 1 1 2 3 3 3 0 MbeD/MobD like DUF3287 PF11690.3 AMD22837.1 - 0.023 14.7 4.0 0.023 14.7 2.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) bZIP_1 PF00170.16 AMD22837.1 - 0.03 14.2 38.5 0.05 13.5 5.7 4.6 1 1 3 4 4 4 0 bZIP transcription factor Lectin_N PF03954.9 AMD22837.1 - 0.031 13.6 15.6 0.022 14.1 5.3 2.4 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF4201 PF13870.1 AMD22837.1 - 0.057 12.8 35.3 0.21 11.0 15.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Spc24 PF08286.6 AMD22837.1 - 0.064 12.9 38.1 0.17 11.5 1.2 4.0 1 1 2 3 3 2 0 Spc24 subunit of Ndc80 Filament PF00038.16 AMD22837.1 - 0.067 12.6 33.3 0.33 10.3 23.1 1.8 1 1 0 1 1 1 0 Intermediate filament protein APG6 PF04111.7 AMD22837.1 - 0.077 12.0 43.5 0.44 9.5 20.2 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 BLOC1_2 PF10046.4 AMD22837.1 - 0.082 13.0 30.3 0.78 9.9 7.9 3.3 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spectrin PF00435.16 AMD22837.1 - 0.11 12.7 32.1 0.98 9.7 8.9 3.1 1 1 2 3 3 3 0 Spectrin repeat IncA PF04156.9 AMD22837.1 - 0.12 11.9 41.3 3.1 7.3 28.6 2.0 1 1 0 1 1 1 0 IncA protein Phage_GP20 PF06810.6 AMD22837.1 - 0.12 11.7 36.4 0.47 9.8 10.2 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 WXG100 PF06013.7 AMD22837.1 - 0.12 12.3 16.2 3.5 7.6 3.7 3.9 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Reo_sigmaC PF04582.7 AMD22837.1 - 0.13 11.4 8.2 0.47 9.5 1.4 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein EzrA PF06160.7 AMD22837.1 - 0.15 10.2 32.7 0.52 8.4 16.2 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF904 PF06005.7 AMD22837.1 - 0.16 12.3 50.3 4.2 7.7 7.9 4.0 2 1 1 3 3 2 0 Protein of unknown function (DUF904) TPR_MLP1_2 PF07926.7 AMD22837.1 - 0.16 11.7 43.2 0.09 12.5 11.1 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF972 PF06156.8 AMD22837.1 - 0.18 12.1 33.5 1.5e+04 -4.1 23.2 3.1 1 1 0 1 1 0 0 Protein of unknown function (DUF972) KLRAQ PF10205.4 AMD22837.1 - 0.2 11.6 27.1 2.1 8.4 9.6 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Prefoldin_2 PF01920.15 AMD22837.1 - 0.25 11.1 45.6 0.93 9.2 2.8 4.2 1 1 3 4 4 4 0 Prefoldin subunit IFT57 PF10498.4 AMD22837.1 - 0.27 9.9 31.9 5.7 5.5 22.1 2.0 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Nup54 PF13874.1 AMD22837.1 - 0.28 10.8 25.3 0.072 12.7 8.8 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF4200 PF13863.1 AMD22837.1 - 0.37 10.7 41.8 5.2 7.0 13.3 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ERM PF00769.14 AMD22837.1 - 0.43 10.0 41.1 3.5 7.1 21.8 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Ax_dynein_light PF10211.4 AMD22837.1 - 0.43 10.3 36.5 0.62 9.8 1.9 3.0 1 1 2 3 3 3 0 Axonemal dynein light chain CCDC155 PF14662.1 AMD22837.1 - 0.46 10.0 40.2 2.6 7.6 4.2 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 PspA_IM30 PF04012.7 AMD22837.1 - 0.51 9.6 29.0 0.92 8.8 19.9 1.6 1 1 0 1 1 1 0 PspA/IM30 family AAA_27 PF13514.1 AMD22837.1 - 0.59 7.7 27.8 1.2 6.6 19.3 1.5 1 1 0 1 1 1 0 AAA domain bZIP_2 PF07716.10 AMD22837.1 - 0.59 9.9 37.9 2.4 8.0 1.0 4.7 2 1 2 4 4 4 0 Basic region leucine zipper DUF1664 PF07889.7 AMD22837.1 - 0.7 9.6 19.5 0.64 9.8 4.3 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.1 AMD22837.1 - 0.71 8.2 31.6 1.4 7.2 21.9 1.5 1 1 0 1 1 1 0 AAA domain Fzo_mitofusin PF04799.8 AMD22837.1 - 0.72 9.2 22.1 0.51 9.6 3.9 2.7 1 1 1 2 2 2 0 fzo-like conserved region Lebercilin PF15619.1 AMD22837.1 - 0.81 9.0 38.4 1.4 8.2 26.6 1.5 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease HOOK PF05622.7 AMD22837.1 - 1 7.1 32.2 1.2 6.8 22.4 1.2 1 0 0 1 1 1 0 HOOK protein Atg14 PF10186.4 AMD22837.1 - 1.1 8.1 28.6 1.1 8.1 8.5 2.0 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DivIC PF04977.10 AMD22837.1 - 1.2 8.6 37.4 5.2 6.6 2.4 4.2 1 1 3 4 4 4 0 Septum formation initiator CALCOCO1 PF07888.6 AMD22837.1 - 1.5 6.9 29.7 2.7 6.1 20.6 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Seryl_tRNA_N PF02403.17 AMD22837.1 - 1.5 8.8 33.1 3.7 7.6 0.6 3.2 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF3584 PF12128.3 AMD22837.1 - 1.5 6.0 30.9 2.2 5.5 21.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TFR_dimer PF04253.10 AMD22837.1 - 1.6 8.2 8.9 22 4.6 3.6 3.0 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain MIS13 PF08202.6 AMD22837.1 - 1.7 7.6 29.5 15 4.5 4.6 2.2 1 1 1 2 2 2 0 Mis12-Mtw1 protein family Spc7 PF08317.6 AMD22837.1 - 1.9 7.1 35.5 5.5 5.5 15.1 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein Fmp27_WPPW PF10359.4 AMD22837.1 - 1.9 6.7 29.2 2.2 6.5 13.1 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Rab5-bind PF09311.6 AMD22837.1 - 2 8.2 37.7 29 4.4 26.1 2.3 1 1 0 1 1 1 0 Rabaptin-like protein NPV_P10 PF05531.7 AMD22837.1 - 2.1 8.6 15.6 2.2 8.5 0.1 3.6 1 1 1 2 2 1 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 AMD22837.1 - 2.2 8.2 28.5 5.8 6.8 0.6 4.8 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) Cortex-I_coil PF09304.5 AMD22837.1 - 2.4 8.2 33.8 2.1 8.4 10.2 3.0 1 1 2 3 3 3 0 Cortexillin I, coiled coil Mnd1 PF03962.10 AMD22837.1 - 2.7 7.5 35.6 3.5 7.2 11.9 2.3 1 1 1 2 2 2 0 Mnd1 family Kinetocho_Slk19 PF12709.2 AMD22837.1 - 3 7.9 37.8 1.1 9.3 4.6 4.0 1 1 3 4 4 4 0 Central kinetochore-associated FliD_C PF07195.7 AMD22837.1 - 3.1 7.0 21.1 3.1 7.0 0.6 3.0 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus Adeno_PIX PF03955.9 AMD22837.1 - 3.2 8.3 17.6 11 6.5 3.4 3.2 1 1 2 3 3 3 0 Adenovirus hexon-associated protein (IX) THOC7 PF05615.8 AMD22837.1 - 3.3 7.9 36.2 8.7 6.6 8.6 2.2 1 1 1 2 2 2 0 Tho complex subunit 7 MAD PF05557.8 AMD22837.1 - 3.5 5.6 39.0 4.5 5.2 27.0 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein OmpH PF03938.9 AMD22837.1 - 4.3 7.2 35.3 1.8 8.4 9.4 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Fumble PF03630.9 AMD22837.1 - 4.7 5.9 10.6 5.6 5.7 7.3 1.2 1 0 0 1 1 1 0 Fumble DUF869 PF05911.6 AMD22837.1 - 4.9 5.2 34.7 9.9 4.2 24.0 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) MeMO_Hyd_G PF02964.11 AMD22837.1 - 5.1 6.9 9.6 0.84 9.5 2.9 2.0 1 1 1 2 2 2 0 Methane monooxygenase, hydrolase gamma chain Striatin PF08232.7 AMD22837.1 - 5.4 7.3 28.5 1.9 8.7 0.5 2.3 1 1 1 2 2 2 0 Striatin family Fib_alpha PF08702.5 AMD22837.1 - 5.6 7.0 22.8 11 6.1 0.3 2.7 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Lge1 PF11488.3 AMD22837.1 - 5.9 7.1 33.8 15 5.8 7.8 3.0 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DegT_DnrJ_EryC1 PF01041.12 AMD22837.1 - 6 5.7 7.3 7 5.5 5.0 1.1 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Rootletin PF15035.1 AMD22837.1 - 6.3 6.7 39.2 55 3.6 8.5 2.8 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion TMCO5 PF14992.1 AMD22837.1 - 6.3 5.8 35.3 21 4.0 10.4 2.5 1 1 1 2 2 2 0 TMCO5 family Prominin PF05478.6 AMD22837.1 - 7.1 4.0 19.9 1.1e+02 0.1 13.6 2.0 1 1 0 1 1 1 0 Prominin Tweety PF04906.8 AMD22837.1 - 7.3 4.8 8.2 4.6 5.5 4.2 1.7 1 1 0 1 1 1 0 Tweety DivIVA PF05103.8 AMD22837.1 - 7.4 6.6 35.3 7.2 6.6 3.7 3.9 1 1 2 3 3 3 0 DivIVA protein Dor1 PF04124.7 AMD22837.1 - 7.9 4.8 20.9 3.9 5.8 12.8 1.6 1 1 0 1 1 1 0 Dor1-like family CDC37_N PF03234.9 AMD22837.1 - 9.6 6.4 32.3 14 5.9 16.3 2.1 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding EOS1 PF12326.3 AMD22838.1 - 5.5e-68 227.2 11.3 1.2e-67 226.1 7.8 1.6 1 1 0 1 1 1 1 N-glycosylation protein Ribosomal_S13 PF00416.17 AMD22839.1 - 1.4e-21 76.8 0.0 1.7e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 AMD22839.1 - 0.018 13.6 0.0 0.018 13.6 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DNA_mis_repair PF01119.14 AMD22840.1 - 6.5e-26 90.1 1.6 1.1e-25 89.3 0.0 2.2 3 0 0 3 3 3 1 DNA mismatch repair protein, C-terminal domain MutL_C PF08676.6 AMD22840.1 - 1.4e-23 83.1 0.0 3.1e-23 81.9 0.0 1.6 1 0 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c_3 PF13589.1 AMD22840.1 - 1.8e-16 60.0 0.0 6.6e-16 58.2 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 AMD22840.1 - 2.1e-10 40.2 0.0 6e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Carot_N PF09150.5 AMD22840.1 - 0.04 13.6 0.0 0.088 12.4 0.0 1.5 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal HORMA PF02301.13 AMD22841.1 - 1.8e-18 66.7 0.1 2.2e-18 66.4 0.1 1.1 1 0 0 1 1 1 1 HORMA domain RBD-FIP PF09457.5 AMD22841.1 - 0.11 12.2 2.8 0.16 11.7 0.4 2.4 3 0 0 3 3 3 0 FIP domain Mito_carr PF00153.22 AMD22842.1 - 4.6e-62 205.7 2.8 7.8e-21 73.5 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 AMD22842.1 - 2.3e-15 56.4 2.7 7.9e-09 35.5 0.3 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 AMD22842.1 - 6e-15 53.3 2.5 0.0015 17.7 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 AMD22842.1 - 2.3e-14 51.9 2.4 0.0096 15.7 0.0 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 AMD22842.1 - 1.7e-09 36.5 2.9 0.00024 20.2 0.1 3.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 AMD22842.1 - 0.0013 18.3 2.6 0.021 14.3 0.2 3.3 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.1 AMD22842.1 - 0.0099 15.7 0.0 2.2 8.2 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.4 AMD22842.1 - 0.079 12.9 2.3 0.25 11.3 0.8 2.2 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region 4HBT PF03061.17 AMD22843.1 - 0.00014 21.9 0.2 0.48 10.5 0.0 2.8 2 1 0 2 2 2 2 Thioesterase superfamily He_PIG PF05345.7 AMD22844.1 - 3.8e-06 26.8 2.3 0.0076 16.2 0.0 4.0 4 0 0 4 4 4 2 Putative Ig domain SKG6 PF08693.5 AMD22844.1 - 0.00037 19.7 0.2 0.00089 18.5 0.1 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain EF-hand_4 PF12763.2 AMD22845.1 - 8.2e-49 163.6 6.8 1.2e-48 163.1 1.1 2.7 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand End3 PF12761.2 AMD22845.1 - 3.7e-39 134.4 11.0 1e-38 132.9 7.7 1.7 1 1 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 Med4 PF10018.4 AMD22845.1 - 0.015 14.7 3.1 0.015 14.7 2.2 2.6 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 EF-hand_1 PF00036.27 AMD22845.1 - 0.019 14.2 1.9 0.068 12.5 1.3 2.0 1 0 0 1 1 1 0 EF hand Fib_alpha PF08702.5 AMD22845.1 - 0.02 15.0 4.5 0.047 13.8 3.1 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4094 PF13334.1 AMD22845.1 - 0.033 14.5 2.4 0.033 14.5 1.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) FlaC_arch PF05377.6 AMD22845.1 - 0.08 12.8 2.3 0.25 11.2 0.1 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) EF-hand_8 PF13833.1 AMD22845.1 - 0.091 12.3 1.1 0.25 10.9 0.7 1.8 2 0 0 2 2 2 0 EF-hand domain pair TBPIP PF07106.8 AMD22845.1 - 1.1 8.8 9.5 1.1 8.8 0.4 2.9 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin-6_N PF09177.6 AMD22845.1 - 1.1 9.7 7.4 2.9 8.3 2.2 2.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF4404 PF14357.1 AMD22845.1 - 3.5 8.1 6.9 5.7 7.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Cpn60_TCP1 PF00118.19 AMD22846.1 - 3e-142 474.6 11.7 3.6e-142 474.4 8.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Transposase_23 PF03017.9 AMD22846.1 - 0.026 14.0 0.0 0.086 12.3 0.0 1.8 1 0 0 1 1 1 0 TNP1/EN/SPM transposase zf-Apc11 PF12861.2 AMD22847.1 - 1.6e-41 140.0 6.9 2.1e-41 139.6 4.8 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 AMD22847.1 - 1.9e-28 98.3 9.7 2.7e-28 97.8 6.7 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 AMD22847.1 - 5.7e-07 29.2 19.8 2.8e-06 27.0 13.0 2.7 1 1 1 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 AMD22847.1 - 0.00022 20.8 13.6 0.0044 16.7 10.0 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.1 AMD22847.1 - 0.0059 16.1 14.4 0.008 15.7 1.4 3.1 2 1 1 3 3 3 1 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.1 AMD22847.1 - 0.02 14.9 15.4 0.2 11.7 10.7 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 AMD22847.1 - 0.024 14.3 13.7 0.98 9.1 9.6 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD22847.1 - 0.04 13.5 17.6 0.38 10.4 12.2 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Coleoptericin PF06286.6 AMD22847.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Coleoptericin zf-HC5HC2H PF13771.1 AMD22847.1 - 0.16 12.1 8.8 0.52 10.4 6.1 1.9 1 1 0 1 1 1 0 PHD-like zinc-binding domain Opy2 PF09463.5 AMD22847.1 - 0.19 11.8 11.7 0.1 12.6 4.5 2.3 2 0 0 2 2 2 0 Opy2 protein zf-HIT PF04438.11 AMD22847.1 - 0.28 10.8 9.4 0.093 12.3 3.4 2.2 2 0 0 2 2 2 0 HIT zinc finger zf-HC5HC2H_2 PF13832.1 AMD22847.1 - 0.33 10.9 8.5 0.13 12.2 3.7 1.9 1 1 0 1 1 1 0 PHD-zinc-finger like domain FANCL_C PF11793.3 AMD22847.1 - 0.57 10.1 20.3 3.4 7.7 12.3 3.6 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING-like PF08746.6 AMD22847.1 - 0.82 9.7 13.7 4.7 7.3 9.5 2.3 1 1 0 1 1 1 0 RING-like domain zf-Nse PF11789.3 AMD22847.1 - 1.6 8.3 5.9 3.2 7.3 4.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.1 AMD22847.1 - 3.6 7.5 13.2 2.3 8.1 6.9 2.4 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 AMD22847.1 - 9.4 6.1 8.8 9.2 6.1 3.7 2.4 1 1 1 2 2 2 0 zf-RING of BARD1-type protein Glutaredoxin PF00462.19 AMD22848.1 - 4.6e-12 45.7 0.0 9.8e-12 44.6 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 AMD22848.1 - 0.0074 16.4 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Mannosyl_trans3 PF11051.3 AMD22849.1 - 1.5e-80 270.4 0.0 2.8e-80 269.5 0.0 1.4 2 0 0 2 2 2 1 Mannosyltransferase putative DUF2611 PF11022.3 AMD22850.1 - 2.5e-23 81.9 0.0 2.7e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) Rsm22 PF09243.5 AMD22850.1 - 0.0066 15.5 0.0 0.0072 15.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Brix PF04427.13 AMD22851.1 - 5.2e-42 143.6 0.2 6.6e-42 143.3 0.2 1.1 1 0 0 1 1 1 1 Brix domain Peptidase_M11 PF05548.6 AMD22851.1 - 0.074 11.9 0.1 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Gametolysin peptidase M11 NatB_MDM20 PF09797.4 AMD22852.1 - 9.5e-63 212.0 3.7 9.5e-63 212.0 2.6 1.8 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit DUF2605 PF10792.4 AMD22853.1 - 0.15 11.7 0.4 12 5.5 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2605) SIN1 PF05422.7 AMD22854.1 - 9.3e-28 97.0 0.0 4.6e-27 94.7 0.0 1.9 1 1 0 1 1 1 1 Stress-activated map kinase interacting protein 1 (SIN1) TUG-UBL1 PF11470.3 AMD22854.1 - 6.1e-06 26.0 0.1 3.6e-05 23.5 0.1 2.3 2 0 0 2 2 2 1 GLUT4 regulating protein TUG RNase_T PF00929.19 AMD22855.1 - 1.6e-25 90.3 0.0 2.6e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 AMD22855.1 - 0.00051 19.5 0.0 0.0044 16.5 0.0 2.5 1 1 0 1 1 1 1 3'-5' exonuclease K167R PF08065.7 AMD22855.1 - 0.16 12.0 10.1 0.29 11.2 7.0 1.3 1 0 0 1 1 1 0 K167R (NUC007) repeat RasGAP PF00616.14 AMD22856.1 - 9.5e-36 123.3 0.0 3.1e-35 121.6 0.0 2.0 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase DUF3321 PF11968.3 AMD22857.1 - 4.8e-83 278.1 0.1 6.4e-83 277.7 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 AMD22857.1 - 0.0012 18.5 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AMD22857.1 - 0.071 13.5 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DEAD PF00270.24 AMD22858.1 - 5.2e-38 130.1 0.0 1.3e-37 128.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22858.1 - 5.1e-25 87.1 0.0 2.2e-24 85.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain FAM176 PF14851.1 AMD22858.1 - 2.1 8.0 7.8 1.9 8.1 4.1 2.0 1 1 0 1 1 1 0 FAM176 family eRF1_2 PF03464.10 AMD22859.1 - 1.7e-46 157.8 0.1 3.1e-46 156.9 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 AMD22859.1 - 9.3e-39 132.2 0.5 2.1e-38 131.0 0.4 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 AMD22859.1 - 3.2e-28 97.9 0.1 6.5e-28 96.9 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 1 ATG19_autophagy PF12744.2 AMD22860.1 - 3.6e-14 52.6 3.2 7.7e-14 51.5 2.2 1.6 1 0 0 1 1 1 1 Autophagy protein Atg19, Atg8-binding ZZ PF00569.12 AMD22860.1 - 1e-07 31.3 35.2 1.9e-06 27.3 6.2 4.5 4 1 0 4 4 4 2 Zinc finger, ZZ type DUF221 PF02714.10 AMD22861.1 - 8.5e-103 343.6 17.2 8.5e-103 343.6 11.9 2.4 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 AMD22861.1 - 2.8e-35 121.1 3.5 2.8e-35 121.1 2.4 3.5 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 AMD22861.1 - 4.7e-19 68.0 0.0 1e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 AMD22861.1 - 9.6e-15 54.8 2.0 1.6e-14 54.1 1.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) RRM_1 PF00076.17 AMD22861.1 - 0.044 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gp_dh_C PF02800.15 AMD22862.1 - 1.4e-73 245.5 0.0 3.5e-73 244.2 0.0 1.6 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 AMD22862.1 - 1.9e-60 203.2 1.7 4.9e-59 198.6 0.3 2.1 2 0 0 2 2 2 2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 AMD22862.1 - 0.0053 16.6 0.6 0.016 15.1 0.1 2.2 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.21 AMD22863.1 - 9.4e-33 112.5 1.0 1.4e-32 111.9 0.7 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AMD22863.1 - 9.4e-30 102.5 0.2 2.4e-29 101.2 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DapB_N PF01113.15 AMD22863.1 - 0.1 12.4 0.6 0.23 11.3 0.4 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Ribosomal_S9 PF00380.14 AMD22864.1 - 5.1e-40 136.4 0.3 5.1e-40 136.4 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein S9/S16 CENP-S PF15630.1 AMD22865.1 - 2.5e-25 88.4 0.0 3.2e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 AMD22865.1 - 0.00047 19.5 0.0 0.00062 19.1 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Nbs1_C PF08599.5 AMD22865.1 - 0.06 13.2 0.1 0.12 12.2 0.1 1.5 1 1 0 1 1 1 0 DNA damage repair protein Nbs1 DUF3337 PF11816.3 AMD22866.1 - 5.6e-61 206.7 0.0 7.3e-59 199.8 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3337) WD40 PF00400.27 AMD22866.1 - 1.4e-10 40.5 2.6 0.0042 16.9 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat RNA_pol_Rpb5_N PF03871.9 AMD22867.1 - 2.3e-33 114.4 0.3 4.2e-33 113.6 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain RNA_pol_Rpb5_C PF01191.14 AMD22867.1 - 3.8e-33 112.8 0.5 6.5e-33 112.1 0.4 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain Sof1 PF04158.9 AMD22867.1 - 0.071 13.1 0.3 0.13 12.3 0.2 1.4 1 0 0 1 1 1 0 Sof1-like domain RibD_C PF01872.12 AMD22868.1 - 3.7e-30 105.0 0.0 4.2e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain Prp19_bind PF06991.6 AMD22869.1 - 1.4e-05 24.5 14.8 2.3e-05 23.8 10.2 1.4 1 0 0 1 1 1 1 Splicing factor, Prp19-binding domain PBP_sp32 PF07222.7 AMD22869.1 - 0.88 8.6 8.6 0.027 13.6 1.3 1.9 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Tox-URI2 PF15653.1 AMD22869.1 - 3.9 7.7 9.0 0.33 11.1 2.1 2.1 2 0 0 2 2 2 0 URI fold toxin 2 Thioredoxin PF00085.15 AMD22870.1 - 7.6e-15 54.4 0.1 5.7e-14 51.6 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.1 AMD22870.1 - 0.00023 21.1 0.0 0.00057 19.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.1 AMD22870.1 - 0.00078 19.6 0.1 0.0019 18.3 0.0 1.7 2 1 0 2 2 2 1 Thioredoxin-like domain DUF4062 PF13271.1 AMD22870.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) Suc_Fer-like PF06999.7 AMD22871.1 - 2.1e-51 175.1 0.1 2.6e-51 174.8 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like FliH PF02108.11 AMD22871.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Flagellar assembly protein FliH Spc7 PF08317.6 AMD22873.1 - 0.00027 19.7 8.8 0.00045 18.9 6.1 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Phage_GP20 PF06810.6 AMD22873.1 - 0.00069 19.0 14.0 0.0049 16.3 9.4 2.2 1 1 1 2 2 2 1 Phage minor structural protein GP20 Jnk-SapK_ap_N PF09744.4 AMD22873.1 - 0.00071 19.5 9.3 0.0012 18.8 6.4 1.4 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 IncA PF04156.9 AMD22873.1 - 0.0038 16.8 15.5 0.0093 15.5 10.6 1.6 1 1 0 1 1 1 1 IncA protein DUF641 PF04859.7 AMD22873.1 - 0.0043 16.8 1.1 0.0043 16.8 0.7 2.5 1 1 1 2 2 2 1 Plant protein of unknown function (DUF641) Reo_sigmaC PF04582.7 AMD22873.1 - 0.0086 15.2 1.2 0.013 14.7 0.8 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein TMF_DNA_bd PF12329.3 AMD22873.1 - 0.0093 15.7 11.2 0.17 11.6 1.4 2.7 2 0 0 2 2 2 2 TATA element modulatory factor 1 DNA binding bZIP_1 PF00170.16 AMD22873.1 - 0.016 15.1 10.6 0.38 10.7 0.1 4.0 2 1 2 4 4 4 0 bZIP transcription factor FliJ PF02050.11 AMD22873.1 - 0.024 14.6 10.9 0.11 12.5 0.9 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein ADIP PF11559.3 AMD22873.1 - 0.025 14.4 17.0 0.73 9.7 5.6 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Cep57_MT_bd PF06657.8 AMD22873.1 - 0.035 14.0 5.5 0.11 12.4 2.2 2.6 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 V_ATPase_I PF01496.14 AMD22873.1 - 0.044 11.6 6.4 0.061 11.1 4.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.3 AMD22873.1 - 0.045 13.0 15.6 0.21 10.8 7.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4201 PF13870.1 AMD22873.1 - 0.086 12.2 15.3 0.038 13.4 5.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) THOC7 PF05615.8 AMD22873.1 - 0.11 12.7 11.6 0.6 10.3 1.3 2.8 1 1 1 2 2 2 0 Tho complex subunit 7 NICE-3 PF07406.6 AMD22873.1 - 0.15 11.5 2.8 0.24 10.8 1.9 1.4 1 1 0 1 1 1 0 NICE-3 protein Prefoldin_2 PF01920.15 AMD22873.1 - 0.2 11.4 13.3 0.93 9.2 3.0 2.7 2 0 0 2 2 2 0 Prefoldin subunit CCDC155 PF14662.1 AMD22873.1 - 0.23 11.0 14.9 0.82 9.2 10.3 1.8 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 COG2 PF06148.6 AMD22873.1 - 0.34 10.7 7.2 4.1 7.2 0.3 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Laminin_II PF06009.7 AMD22873.1 - 0.35 10.6 9.6 0.86 9.3 6.7 1.7 1 0 0 1 1 1 0 Laminin Domain II DUF1664 PF07889.7 AMD22873.1 - 0.45 10.3 8.5 0.84 9.4 1.3 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) SlyX PF04102.7 AMD22873.1 - 0.46 10.8 11.6 5.7 7.3 1.6 2.8 1 1 1 2 2 2 0 SlyX Kinesin-relat_1 PF12711.2 AMD22873.1 - 0.48 10.8 10.5 0.96 9.8 2.0 2.6 1 1 1 2 2 2 0 Kinesin motor TPR_MLP1_2 PF07926.7 AMD22873.1 - 0.56 9.9 18.5 0.61 9.8 3.2 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF848 PF05852.6 AMD22873.1 - 0.61 9.9 15.0 4.3 7.1 4.6 3.2 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF3373 PF11853.3 AMD22873.1 - 0.65 8.4 6.6 1 7.7 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF4407 PF14362.1 AMD22873.1 - 0.87 8.4 6.2 1.2 8.0 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.4 AMD22873.1 - 1.1 9.0 15.0 2.9 7.7 10.0 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.8 AMD22873.1 - 1.3 9.3 17.0 10 6.5 2.7 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF972) YlqD PF11068.3 AMD22873.1 - 1.5 8.8 13.3 4.1 7.4 9.1 1.8 1 1 0 1 1 1 0 YlqD protein Lebercilin PF15619.1 AMD22873.1 - 1.5 8.1 19.8 0.12 11.8 9.8 2.1 2 1 0 2 2 1 0 Ciliary protein causing Leber congenital amaurosis disease Uso1_p115_C PF04871.8 AMD22873.1 - 2.2 8.2 15.2 7.6 6.4 4.5 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc24 PF08286.6 AMD22873.1 - 2.8 7.6 12.9 3.1 7.5 2.9 3.0 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 TMF_TATA_bd PF12325.3 AMD22873.1 - 3.1 7.5 15.5 4.1 7.1 3.6 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF1043 PF06295.7 AMD22873.1 - 3.6 7.2 9.6 0.53 9.9 1.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) ATG16 PF08614.6 AMD22873.1 - 3.7 7.3 21.1 2.5 7.8 5.1 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4446 PF14584.1 AMD22873.1 - 4.5 7.0 8.2 15 5.3 1.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DivIVA PF05103.8 AMD22873.1 - 4.7 7.2 15.2 1.1 9.2 6.4 2.3 1 1 2 3 3 3 0 DivIVA protein Tnp_P_element PF12017.3 AMD22873.1 - 5 6.2 10.9 1.3 8.1 1.4 2.3 1 1 1 2 2 2 0 Transposase protein DUF2203 PF09969.4 AMD22873.1 - 5.2 7.3 6.7 5.7 7.1 2.9 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) APG6 PF04111.7 AMD22873.1 - 5.2 6.0 17.3 1.1 8.2 6.7 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Atg14 PF10186.4 AMD22873.1 - 5.5 5.8 16.7 2.6 6.8 9.8 1.8 1 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 CENP-Q PF13094.1 AMD22873.1 - 7.4 6.5 22.3 2.6 8.0 9.2 2.7 2 1 1 3 3 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Mnd1 PF03962.10 AMD22873.1 - 9.7 5.8 16.4 35 4.0 11.3 1.9 1 1 0 1 1 1 0 Mnd1 family CBM_21 PF03370.8 AMD22874.1 - 8.1e-28 96.6 6.2 2.9e-27 94.8 4.3 2.0 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit MCM PF00493.18 AMD22875.1 - 5.7e-141 469.0 0.5 7.4e-141 468.7 0.3 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 AMD22875.1 - 5.9e-19 68.7 0.4 1.9e-18 67.0 0.1 2.0 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.9 AMD22875.1 - 6.7e-06 25.8 0.0 1.8e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 AMD22875.1 - 2.7e-05 23.4 0.0 0.0044 16.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 AMD22875.1 - 0.0023 17.5 0.0 0.0081 15.7 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 AMD22875.1 - 0.011 15.2 0.0 0.55 9.6 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Imm19 PF15567.1 AMD22875.1 - 0.042 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 19 DUF2296 PF10058.4 AMD22875.1 - 0.13 11.9 1.1 6.8 6.5 0.1 2.6 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Mg_chelatase_2 PF13335.1 AMD22875.1 - 0.36 11.2 3.3 0.43 11.0 0.5 2.6 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI LSM PF01423.17 AMD22876.1 - 4.7e-18 64.4 1.0 5.9e-18 64.1 0.7 1.1 1 0 0 1 1 1 1 LSM domain DEAD PF00270.24 AMD22877.1 - 1.5e-36 125.4 0.3 3.1e-36 124.4 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AMD22877.1 - 1.9e-23 82.1 0.0 9e-12 44.7 0.0 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 AMD22877.1 - 4e-06 26.7 0.9 0.0001 22.2 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CPSF73-100_C PF11718.3 AMD22878.1 - 2.3e-60 203.6 0.7 2.3e-60 203.6 0.5 1.6 2 0 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 AMD22878.1 - 5.1e-33 113.6 0.0 3e-32 111.2 0.0 2.2 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 AMD22878.1 - 5.3e-16 58.8 0.7 8.6e-16 58.1 0.5 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 AMD22878.1 - 4.1e-13 49.3 1.0 2.8e-12 46.6 0.3 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.7 AMD22878.1 - 1.8e-10 40.4 0.2 4.5e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 AMD22878.1 - 2.9e-06 27.0 0.1 1e-05 25.3 0.1 1.9 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Fungal_trans PF04082.13 AMD22879.1 - 4.7e-17 61.7 0.9 1.2e-16 60.4 0.6 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD22879.1 - 0.00053 19.8 10.6 0.00053 19.8 7.3 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RF-1 PF00472.15 AMD22880.1 - 2.6e-18 65.8 7.5 6.3e-18 64.6 5.2 1.6 1 1 0 1 1 1 1 RF-1 domain CBP4 PF07960.6 AMD22880.1 - 0.019 14.5 4.6 0.03 13.9 3.2 1.3 1 0 0 1 1 1 0 CBP4 DUF2924 PF11149.3 AMD22880.1 - 0.12 12.3 1.2 0.16 11.9 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) DUF1640 PF07798.6 AMD22881.1 - 1.8e-07 31.3 0.2 2.7e-07 30.8 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) NLE PF08154.7 AMD22881.1 - 0.29 11.1 5.2 0.12 12.4 0.7 2.2 2 0 0 2 2 2 0 NLE (NUC135) domain ECH PF00378.15 AMD22882.1 - 1.2e-21 76.9 0.0 1.4e-21 76.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family FAST_1 PF06743.10 AMD22882.1 - 0.028 14.1 0.3 0.081 12.6 0.2 1.7 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 Init_tRNA_PT PF04179.7 AMD22882.1 - 0.047 12.5 0.0 0.063 12.1 0.0 1.2 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase Methyltransf_16 PF10294.4 AMD22883.1 - 8.1e-12 44.9 0.1 1.8e-10 40.5 0.1 2.1 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 AMD22883.1 - 0.00032 20.4 0.0 0.00049 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AMD22883.1 - 0.002 18.6 0.0 0.0036 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain WH1 PF00568.18 AMD22884.1 - 8.3e-29 99.5 0.0 1.2e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 WH1 domain CAP_N PF01213.14 AMD22884.1 - 1.7e-05 24.2 4.9 1.7e-05 24.2 3.4 6.0 3 1 2 5 5 5 1 Adenylate cyclase associated (CAP) N terminal WH2 PF02205.15 AMD22884.1 - 0.00042 19.8 0.3 0.00095 18.6 0.2 1.7 1 0 0 1 1 1 1 WH2 motif GCIP PF13324.1 AMD22885.1 - 3e-05 23.4 0.1 4.4e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting APG6 PF04111.7 AMD22885.1 - 0.015 14.4 4.5 0.31 10.0 0.1 2.7 2 1 1 3 3 3 0 Autophagy protein Apg6 Ribosomal_S30 PF04758.9 AMD22886.1 - 3.4e-30 103.5 5.6 3.9e-30 103.3 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Aminotran_5 PF00266.14 AMD22887.1 - 2.2e-34 118.8 0.0 2.7e-34 118.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Mei5 PF10376.4 AMD22887.1 - 0.037 13.5 0.1 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Double-strand recombination repair protein Hus1 PF04005.7 AMD22888.1 - 1.2e-27 96.6 0.6 7.6e-27 94.0 0.4 1.9 1 1 0 1 1 1 1 Hus1-like protein GTP_EFTU PF00009.22 AMD22889.1 - 6.7e-46 156.1 0.0 1.4e-45 155.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 AMD22889.1 - 8.9e-36 122.0 5.3 8.9e-36 122.0 3.7 1.7 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 AMD22889.1 - 2.9e-17 62.3 0.0 5.6e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 AMD22889.1 - 0.00062 19.8 0.9 0.0015 18.6 0.6 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.17 AMD22889.1 - 0.0028 17.0 0.0 0.0059 16.0 0.0 1.5 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 AMD22889.1 - 0.013 14.7 0.0 0.034 13.3 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NAD_binding_10 PF13460.1 AMD22890.1 - 1.6e-08 34.8 0.0 2.7e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 NADH(P)-binding 3Beta_HSD PF01073.14 AMD22890.1 - 1.5e-05 23.8 0.0 4.4e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 AMD22890.1 - 0.00016 21.1 0.0 0.00033 20.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 AMD22890.1 - 0.00063 18.7 0.0 0.1 11.5 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein IF-2B PF01008.12 AMD22891.1 - 5.1e-78 261.9 0.4 8e-78 261.2 0.2 1.3 1 1 0 1 1 1 1 Initiation factor 2 subunit family SecA_SW PF07516.8 AMD22891.1 - 0.021 14.6 0.1 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 SecA Wing and Scaffold domain TPR_11 PF13414.1 AMD22892.1 - 0.00013 21.5 1.9 0.0013 18.3 0.0 2.4 1 1 1 2 2 2 1 TPR repeat TPR_2 PF07719.12 AMD22892.1 - 0.00027 20.6 3.1 0.005 16.6 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 AMD22892.1 - 0.00036 20.0 1.9 0.0022 17.4 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 AMD22892.1 - 0.00043 20.5 0.4 0.00043 20.5 0.3 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 AMD22892.1 - 0.012 16.2 1.5 0.14 12.8 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 AMD22892.1 - 0.012 15.5 5.6 0.8 9.6 0.1 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat GTPase_Cys_C PF12631.2 AMD22892.1 - 0.025 14.9 0.8 0.072 13.5 0.3 2.1 2 0 0 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE DUF2992 PF11208.3 AMD22892.1 - 0.056 13.3 2.2 0.088 12.7 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) TPR_9 PF13371.1 AMD22892.1 - 0.067 13.0 4.5 0.55 10.1 0.2 2.9 1 1 0 2 2 2 0 Tetratricopeptide repeat Phage_term_smal PF05944.7 AMD22892.1 - 0.1 12.2 0.6 0.3 10.7 0.0 2.0 3 0 0 3 3 3 0 Phage small terminase subunit TPR_16 PF13432.1 AMD22892.1 - 0.12 13.0 3.3 0.21 12.2 0.5 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 AMD22892.1 - 0.66 9.8 7.8 0.35 10.7 0.4 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Ras PF00071.17 AMD22893.1 - 1.1e-50 171.1 0.0 1.4e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22893.1 - 6.1e-17 62.2 0.0 1.3e-16 61.1 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 AMD22893.1 - 1.7e-11 43.6 0.0 2.4e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.17 AMD22893.1 - 0.00082 19.5 0.1 0.0054 16.8 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.7 AMD22893.1 - 0.0011 18.1 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 AMD22893.1 - 0.014 14.5 0.0 0.025 13.7 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit KaiC PF06745.8 AMD22893.1 - 0.02 14.0 0.2 0.03 13.4 0.1 1.2 1 0 0 1 1 1 0 KaiC Pox_A32 PF04665.7 AMD22893.1 - 0.025 13.8 0.1 0.042 13.1 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_22 PF13401.1 AMD22893.1 - 0.041 14.0 0.2 0.16 12.1 0.1 2.0 1 1 1 2 2 2 0 AAA domain G-alpha PF00503.15 AMD22893.1 - 0.054 12.1 2.7 1.1 7.8 0.1 2.7 2 1 1 3 3 3 0 G-protein alpha subunit AAA_33 PF13671.1 AMD22893.1 - 0.071 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 AMD22893.1 - 0.14 11.7 0.1 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ADIP PF11559.3 AMD22894.1 - 0.00051 19.9 0.9 0.0011 18.9 0.1 1.9 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding DUF3498 PF12004.3 AMD22894.1 - 0.011 14.8 1.6 0.013 14.6 0.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3498) ATP_sub_h PF10775.4 AMD22895.1 - 7.4e-28 96.0 0.6 1e-27 95.6 0.4 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h zf-U1 PF06220.7 AMD22896.1 - 6.2e-18 64.0 5.7 6.2e-18 64.0 3.9 2.2 2 0 0 2 2 2 1 U1 zinc finger Cylicin_N PF15241.1 AMD22896.1 - 0.0047 16.7 0.4 0.0096 15.7 0.3 1.5 1 0 0 1 1 1 1 Cylicin N-terminus zf-C2H2_jaz PF12171.3 AMD22896.1 - 1.4 9.1 8.6 1.4 9.1 4.4 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding McyA_C PF12593.3 AMD22896.1 - 3.3 7.5 5.5 1.5 8.5 0.2 2.9 3 0 0 3 3 3 0 Microcystin synthetase C terminal GTP_EFTU PF00009.22 AMD22897.1 - 5.1e-61 205.3 0.2 6.8e-61 204.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 AMD22897.1 - 7.4e-26 90.2 0.0 1.8e-25 88.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 AMD22897.1 - 6e-21 74.3 1.4 1.6e-20 72.9 1.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AMD22897.1 - 1.8e-05 24.6 0.0 3.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 AMD22897.1 - 5e-05 22.8 0.2 0.00013 21.4 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Miro PF08477.8 AMD22897.1 - 0.0005 20.5 0.0 0.0009 19.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 AMD22897.1 - 0.062 12.7 0.6 8.4 5.8 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DisA_N PF02457.11 AMD22897.1 - 0.083 12.0 0.1 0.26 10.4 0.0 1.8 2 0 0 2 2 2 0 DisA bacterial checkpoint controller nucleotide-binding CbiA PF01656.18 AMD22897.1 - 0.28 10.5 2.1 5 6.4 0.0 2.4 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain G_glu_transpept PF01019.16 AMD22898.1 - 1.8e-139 465.5 0.0 2.3e-139 465.2 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF1708 PF08101.6 AMD22899.1 - 2.7e-132 441.5 3.3 7.1e-132 440.1 2.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) Cellulase PF00150.13 AMD22901.1 - 1.5e-11 44.0 0.1 1.5e-10 40.7 0.0 2.3 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) SNF2_N PF00176.18 AMD22902.1 - 6.4e-67 225.4 0.4 6.4e-67 225.4 0.3 2.6 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD22902.1 - 8.2e-13 48.0 0.0 3.9e-12 45.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 AMD22902.1 - 7.9e-07 28.9 1.0 2.3e-06 27.4 0.8 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 AMD22902.1 - 4.5e-06 26.2 2.2 9.4e-06 25.2 1.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 AMD22902.1 - 4.7e-06 26.3 3.2 9.9e-06 25.2 2.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 AMD22902.1 - 3.1e-05 23.5 2.9 6.4e-05 22.5 2.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD22902.1 - 0.00027 20.5 2.3 0.00061 19.3 1.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 AMD22902.1 - 0.00066 19.3 0.6 0.0023 17.6 0.4 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 AMD22902.1 - 0.25 11.2 2.5 0.75 9.7 1.8 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 AMD22902.1 - 0.35 10.4 3.6 0.23 11.0 0.6 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Cornichon PF03311.9 AMD22904.1 - 1.3e-50 170.8 9.9 1.5e-50 170.6 6.8 1.0 1 0 0 1 1 1 1 Cornichon protein DUF1634 PF07843.6 AMD22904.1 - 0.035 13.7 0.2 0.068 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) DUF1673 PF07895.6 AMD22904.1 - 2 7.8 6.4 1.5 8.2 3.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) RRM_1 PF00076.17 AMD22906.1 - 2.7e-40 135.8 0.0 6.8e-18 64.0 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 AMD22906.1 - 2.1e-26 91.6 0.0 6.1e-13 48.5 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 AMD22906.1 - 4e-19 68.2 0.0 6e-07 29.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 AMD22906.1 - 1.3e-06 28.2 0.1 3.1e-05 23.7 0.0 2.4 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.1 AMD22906.1 - 0.021 14.5 0.0 0.08 12.7 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif EMP70 PF02990.11 AMD22907.1 - 5e-197 655.4 10.5 6.3e-197 655.1 7.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 TRAPPC-Trs85 PF12739.2 AMD22908.1 - 8.6e-74 248.6 0.0 1.3e-73 248.0 0.0 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF3136 PF11334.3 AMD22908.1 - 0.053 12.9 0.0 8.5 5.8 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3136) Rax2 PF12768.2 AMD22909.1 - 8.3e-55 185.9 2.9 3.2e-54 184.0 0.0 3.2 3 1 1 4 4 4 1 Cortical protein marker for cell polarity GCR1_C PF12550.3 AMD22910.1 - 1.5e-11 44.0 0.1 3.2e-11 42.9 0.1 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Reo_sigmaC PF04582.7 AMD22910.1 - 0.15 11.1 3.1 0.26 10.4 2.2 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein FGGY_C PF02782.11 AMD22911.1 - 4e-36 124.5 0.0 7.8e-36 123.5 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 AMD22911.1 - 2.4e-23 82.7 0.0 1.4e-22 80.2 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.16 AMD22911.1 - 0.001 18.4 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Actin PF00022.14 AMD22912.1 - 4.4e-51 173.5 0.0 5.3e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 Actin SMC_N PF02463.14 AMD22913.1 - 9.7e-65 217.8 59.8 3.9e-64 215.9 41.5 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 AMD22913.1 - 2.7e-28 98.3 0.2 7.8e-28 96.8 0.0 2.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 AMD22913.1 - 9.5e-10 38.9 10.9 3.3e-07 30.5 0.0 5.4 3 2 2 5 5 5 2 AAA domain AAA_29 PF13555.1 AMD22913.1 - 3.8e-06 26.3 0.0 8.3e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 AMD22913.1 - 0.24 10.5 47.0 0.024 13.8 2.1 5.3 3 2 2 5 5 5 0 Reovirus sigma C capsid protein Gaa1 PF04114.9 AMD22915.1 - 2.4e-115 386.1 18.4 4.3e-109 365.5 3.7 2.1 1 1 1 2 2 2 2 Gaa1-like, GPI transamidase component AAA PF00004.24 AMD22916.1 - 1.6e-13 50.9 0.2 1.8e-12 47.5 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 AMD22916.1 - 5.5e-09 35.2 4.8 0.0013 17.5 0.0 3.8 3 1 1 4 4 4 2 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 AMD22916.1 - 6e-06 27.0 0.0 2.6e-05 25.0 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AMD22916.1 - 0.00012 21.9 0.0 0.00031 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD22916.1 - 0.00015 21.9 0.1 0.00079 19.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 AMD22916.1 - 0.00033 20.6 0.0 0.0011 19.0 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 AMD22916.1 - 0.00056 19.0 0.0 0.0015 17.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 AMD22916.1 - 0.0026 17.4 0.0 0.0059 16.3 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 AMD22916.1 - 0.0028 17.7 0.0 0.0085 16.2 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_11 PF13086.1 AMD22916.1 - 0.0053 16.3 0.8 0.029 13.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 AMD22916.1 - 0.006 16.4 0.1 0.016 15.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD22916.1 - 0.018 15.3 2.2 0.032 14.5 0.0 2.6 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.12 AMD22916.1 - 0.037 13.4 0.0 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF258 PF03193.11 AMD22916.1 - 0.054 12.6 0.2 0.14 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 AMD22916.1 - 0.08 12.6 0.0 0.55 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.1 AMD22916.1 - 0.089 13.1 0.0 0.089 13.1 0.0 3.0 3 1 0 3 3 3 0 AAA domain CRAL_TRIO PF00650.15 AMD22917.1 - 6.5e-35 119.9 0.0 9e-35 119.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 AMD22917.1 - 6.7e-10 38.9 0.0 1.5e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 AMD22917.1 - 0.0018 18.2 0.0 0.0036 17.1 0.0 1.5 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain RasGAP PF00616.14 AMD22918.1 - 1.9e-47 161.5 2.5 1.9e-47 161.5 1.7 1.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.25 AMD22918.1 - 0.0044 16.8 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF3530 PF12048.3 AMD22918.1 - 0.15 11.0 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) UPF1_Zn_bind PF09416.5 AMD22919.1 - 1.1e-66 223.1 11.5 2.4e-66 222.0 8.0 1.6 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.1 AMD22919.1 - 2.5e-58 196.7 0.0 8e-58 195.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 AMD22919.1 - 2.3e-53 181.1 0.4 4.3e-53 180.2 0.3 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 AMD22919.1 - 1.7e-14 53.8 0.0 9.5e-14 51.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AMD22919.1 - 2.4e-13 49.6 0.0 4.7e-12 45.4 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain UvrD-helicase PF00580.16 AMD22919.1 - 2.5e-05 23.7 0.2 0.02 14.2 0.0 3.0 2 1 0 3 3 3 2 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.13 AMD22919.1 - 3.3e-05 23.5 0.0 0.31 10.5 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 AMD22919.1 - 3.7e-05 22.8 1.8 0.00053 19.0 0.0 3.3 2 1 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 AMD22919.1 - 4.2e-05 23.4 0.4 0.00015 21.6 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T2SE PF00437.15 AMD22919.1 - 0.00093 18.1 0.0 0.0017 17.3 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein PIF1 PF05970.9 AMD22919.1 - 0.0014 17.6 0.0 0.99 8.2 0.0 2.3 2 0 0 2 2 2 2 PIF1-like helicase PhoH PF02562.11 AMD22919.1 - 0.0016 17.7 0.0 0.0052 16.0 0.0 1.9 2 0 0 2 2 2 1 PhoH-like protein Helicase_RecD PF05127.9 AMD22919.1 - 0.0026 17.4 0.0 0.0081 15.8 0.0 1.9 1 0 0 1 1 1 1 Helicase DEAD PF00270.24 AMD22919.1 - 0.0044 16.5 0.0 0.0096 15.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD_C_2 PF13538.1 AMD22919.1 - 0.018 15.1 0.0 0.7 10.0 0.0 2.7 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain Mg_chelatase PF01078.16 AMD22919.1 - 0.046 12.8 0.0 0.13 11.3 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 AMD22919.1 - 0.047 13.6 0.5 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.24 AMD22919.1 - 0.13 12.4 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Flavi_DEAD PF07652.9 AMD22919.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Flavivirus DEAD domain DUF572 PF04502.8 AMD22921.1 - 1.9e-48 165.3 11.2 1.9e-48 165.3 7.7 1.9 1 1 1 2 2 2 1 Family of unknown function (DUF572) Mu-like_Com PF10122.4 AMD22921.1 - 0.017 14.1 0.5 0.12 11.4 0.1 2.3 2 0 0 2 2 2 0 Mu-like prophage protein Com RuBisCO_large PF00016.15 AMD22921.1 - 0.091 11.5 0.2 0.13 11.0 0.2 1.2 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, catalytic domain zf-FPG_IleRS PF06827.9 AMD22921.1 - 0.099 12.3 0.8 7.1 6.3 0.1 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS DUF1635 PF07795.6 AMD22921.1 - 0.13 11.6 7.2 0.24 10.7 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Zn_Tnp_IS1 PF03811.8 AMD22921.1 - 0.15 11.5 1.6 0.56 9.7 0.1 2.2 2 0 0 2 2 2 0 InsA N-terminal domain PIR PF00399.14 AMD22923.1 - 7.2e-07 28.3 5.6 3.1e-06 26.3 3.9 2.2 1 0 0 1 1 1 1 Yeast PIR protein repeat RNA_pol_Rpb2_6 PF00562.23 AMD22924.1 - 1.6e-114 382.6 0.0 2.2e-114 382.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 AMD22924.1 - 2.9e-43 147.1 0.0 4.1e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 AMD22924.1 - 9e-32 110.0 0.0 1.8e-31 109.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 AMD22924.1 - 1.7e-24 85.3 0.1 1.4e-23 82.4 0.0 2.7 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.7 AMD22924.1 - 5.3e-24 83.9 0.0 1.1e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.15 AMD22924.1 - 2.2e-15 56.6 0.0 1.3e-14 54.1 0.0 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 AMD22924.1 - 3.7e-06 26.8 0.1 8.3e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Thg1 PF04446.7 AMD22926.1 - 4.5e-46 155.8 1.5 5.6e-46 155.5 0.5 1.5 2 0 0 2 2 2 1 tRNAHis guanylyltransferase Thg1C PF14413.1 AMD22926.1 - 1.1e-37 128.4 0.4 2.2e-37 127.3 0.3 1.5 1 0 0 1 1 1 1 Thg1 C terminal domain Xpo1 PF08389.7 AMD22926.1 - 0.14 12.0 0.6 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Exportin 1-like protein UPF0121 PF03661.8 AMD22927.1 - 0.03 13.5 4.1 0.3 10.2 2.5 2.3 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0121) DUF788 PF05620.6 AMD22927.1 - 1 9.1 6.2 12 5.7 1.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF788) Ribosomal_S25 PF03297.10 AMD22928.1 - 4.2e-44 148.8 5.4 4.7e-44 148.7 3.7 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Ftsk_gamma PF09397.5 AMD22928.1 - 0.0006 19.4 0.1 0.00089 18.9 0.0 1.3 1 0 0 1 1 1 1 Ftsk gamma domain HTH_CodY PF08222.6 AMD22928.1 - 0.038 13.3 0.2 0.061 12.6 0.1 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain HTH_20 PF12840.2 AMD22928.1 - 0.065 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain EAP30 PF04157.11 AMD22928.1 - 0.067 12.3 0.0 0.11 11.6 0.0 1.3 1 1 0 1 1 1 0 EAP30/Vps36 family MerR PF00376.18 AMD22928.1 - 0.069 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 MerR family regulatory protein GntR PF00392.16 AMD22928.1 - 0.12 11.7 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Ran_BP1 PF00638.13 AMD22929.1 - 7.6e-31 106.6 0.1 1.9e-30 105.3 0.0 1.7 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.6 AMD22929.1 - 2.7e-13 50.0 3.2 2.7e-12 46.8 2.2 2.9 1 0 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) MA3 PF02847.12 AMD22930.1 - 1.5e-23 82.6 2.3 4.1e-23 81.2 0.3 2.8 2 2 0 2 2 2 1 MA3 domain MIF4G PF02854.14 AMD22930.1 - 1.3e-19 70.4 6.4 2.6e-19 69.4 4.4 1.6 1 0 0 1 1 1 1 MIF4G domain AAA PF00004.24 AMD22931.1 - 3.4e-37 127.6 0.0 5.8e-37 126.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 AMD22931.1 - 1.7e-07 31.1 0.0 6.6e-07 29.2 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 AMD22931.1 - 7e-07 30.0 0.1 2.3e-06 28.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AMD22931.1 - 1e-06 28.9 0.3 0.0016 18.5 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 AMD22931.1 - 1.8e-06 28.0 1.7 2.5e-05 24.3 0.4 3.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 AMD22931.1 - 4.3e-06 25.9 0.0 9.4e-06 24.8 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 AMD22931.1 - 8.6e-06 25.5 0.1 6.4e-05 22.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 AMD22931.1 - 9e-06 25.7 0.0 2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_2 PF07724.9 AMD22931.1 - 2.3e-05 24.3 0.0 4.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.7 AMD22931.1 - 0.00014 21.0 0.0 0.00024 20.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 AMD22931.1 - 0.00022 21.5 0.1 0.001 19.3 0.0 2.3 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 AMD22931.1 - 0.00037 19.9 0.0 0.00072 19.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 AMD22931.1 - 0.00041 20.2 0.0 0.0022 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 AMD22931.1 - 0.00089 18.4 0.2 0.0023 17.1 0.1 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 AMD22931.1 - 0.001 19.1 0.0 0.0031 17.6 0.0 1.9 1 1 0 1 1 1 1 RNA helicase DUF815 PF05673.8 AMD22931.1 - 0.0012 17.8 0.0 0.0021 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.1 AMD22931.1 - 0.0024 17.2 0.3 0.049 13.0 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.1 AMD22931.1 - 0.0082 16.1 0.0 0.019 14.8 0.0 1.6 2 0 0 2 2 1 1 AAA domain TIP49 PF06068.8 AMD22931.1 - 0.0099 14.6 0.1 0.03 13.0 0.0 1.7 1 1 1 2 2 2 1 TIP49 C-terminus AAA_19 PF13245.1 AMD22931.1 - 0.013 15.1 0.1 0.06 13.0 0.0 2.1 2 0 0 2 2 1 0 Part of AAA domain Sigma54_activat PF00158.21 AMD22931.1 - 0.014 14.8 0.0 0.053 12.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.1 AMD22931.1 - 0.017 14.7 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 AMD22931.1 - 0.017 14.8 0.1 0.069 12.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.22 AMD22931.1 - 0.023 14.9 0.0 0.062 13.6 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Rad17 PF03215.10 AMD22931.1 - 0.023 13.3 0.0 0.033 12.8 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NB-ARC PF00931.17 AMD22931.1 - 0.03 13.1 0.3 0.16 10.8 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_3 PF07726.6 AMD22931.1 - 0.035 13.6 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 AMD22931.1 - 0.048 13.3 0.1 0.7 9.5 0.0 2.4 1 1 1 2 2 2 0 Archaeal ATPase Parvo_NS1 PF01057.12 AMD22931.1 - 0.055 12.3 0.0 0.095 11.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.13 AMD22931.1 - 0.062 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein FCH PF00611.18 AMD22931.1 - 0.074 13.2 0.0 13 6.0 0.0 2.5 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain AAA_10 PF12846.2 AMD22931.1 - 0.079 12.3 0.4 6.6 6.0 0.0 2.6 1 1 1 2 2 2 0 AAA-like domain AAA_21 PF13304.1 AMD22931.1 - 0.085 12.8 0.3 15 5.4 0.1 2.5 1 1 1 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 AMD22931.1 - 0.088 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase KTI12 PF08433.5 AMD22931.1 - 0.1 11.7 0.0 1.6 7.9 0.0 2.1 1 1 1 2 2 2 0 Chromatin associated protein KTI12 SKI PF01202.17 AMD22931.1 - 0.12 12.2 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 Shikimate kinase tRNA_lig_kinase PF08303.6 AMD22931.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 tRNA ligase kinase domain AAA_11 PF13086.1 AMD22931.1 - 0.14 11.6 0.0 0.24 10.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain Evr1_Alr PF04777.8 AMD22932.1 - 9.5e-31 105.5 2.6 9.5e-31 105.5 1.8 1.5 2 0 0 2 2 2 1 Erv1 / Alr family WH2 PF02205.15 AMD22933.1 - 7.8e-14 50.7 1.4 1.6e-10 40.2 0.2 3.1 3 0 0 3 3 3 2 WH2 motif OTU PF02338.14 AMD22934.1 - 5.7e-19 68.8 1.0 1.5e-18 67.5 0.0 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 AMD22934.1 - 0.00011 21.6 4.2 0.00092 18.6 0.0 2.8 3 0 0 3 3 3 2 Peptidase C65 Otubain NifT PF06988.6 AMD22934.1 - 0.39 10.2 3.3 0.6 9.6 0.1 2.7 3 0 0 3 3 3 0 NifT/FixU protein YchF-GTPase_C PF06071.8 AMD22935.1 - 7.4e-32 108.9 0.0 1.5e-31 107.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 AMD22935.1 - 2.6e-13 49.9 0.0 4.8e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 AMD22935.1 - 0.00024 20.4 0.0 0.00053 19.2 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Ribosomal_S10 PF00338.17 AMD22936.1 - 3.7e-26 90.8 0.8 4.9e-26 90.4 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Retrotrans_gag PF03732.12 AMD22936.1 - 0.034 14.2 0.0 0.056 13.5 0.0 1.5 1 1 0 1 1 1 0 Retrotransposon gag protein RII_binding_1 PF10522.4 AMD22936.1 - 0.19 11.9 2.7 1.4 9.3 0.3 2.4 2 0 0 2 2 2 0 RII binding domain Lung_7-TM_R PF06814.8 AMD22937.1 - 8.1e-76 254.7 22.9 1e-75 254.4 15.9 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor UbiA PF01040.13 AMD22937.1 - 0.037 13.2 16.6 0.013 14.7 7.3 2.3 2 0 0 2 2 2 0 UbiA prenyltransferase family SUR7 PF06687.7 AMD22937.1 - 7.4 6.0 12.7 39 3.7 8.8 2.3 1 1 0 1 1 1 0 SUR7/PalI family Nfu_N PF08712.6 AMD22938.1 - 4.9e-24 83.7 0.4 1.9e-23 81.8 0.0 2.1 3 0 0 3 3 3 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 AMD22938.1 - 2.5e-21 75.2 0.0 4.3e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 NifU-like domain YojJ PF10372.4 AMD22938.1 - 0.017 14.9 0.8 0.037 13.8 0.5 1.5 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus Pterin_4a PF01329.14 AMD22939.1 - 3.3e-29 100.4 0.2 3.8e-29 100.2 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Adap_comp_sub PF00928.16 AMD22940.1 - 4.7e-53 179.9 0.1 6.3e-53 179.5 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Opi1 PF08618.5 AMD22941.1 - 8.1e-34 117.2 8.5 1.7e-24 86.5 1.1 3.1 2 1 1 3 3 3 3 Transcription factor Opi1 Seadorna_Vp10 PF07322.6 AMD22941.1 - 0.079 12.2 0.1 0.77 8.9 0.0 2.0 1 1 1 2 2 2 0 Seadornavirus Vp10 FliJ PF02050.11 AMD22941.1 - 0.38 10.8 13.8 0.048 13.7 6.0 2.1 2 0 0 2 2 2 0 Flagellar FliJ protein Snf7 PF03357.16 AMD22942.1 - 1.1e-29 102.9 20.7 1.1e-29 102.9 14.3 1.6 1 1 0 1 1 1 1 Snf7 PAS_7 PF12860.2 AMD22942.1 - 0.0012 18.7 2.2 0.024 14.6 0.2 2.6 1 1 1 2 2 2 1 PAS fold DUF3425 PF11905.3 AMD22942.1 - 0.084 12.7 0.2 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3425) IL22 PF14565.1 AMD22942.1 - 0.13 12.3 2.7 0.19 11.8 1.9 1.4 1 0 0 1 1 1 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor Exotox-A_target PF09102.5 AMD22942.1 - 0.13 11.8 0.1 0.29 10.6 0.1 1.5 1 0 0 1 1 1 0 Exotoxin A, targeting DUF2096 PF09869.4 AMD22942.1 - 0.21 11.4 8.5 0.03 14.2 2.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) CaMBD PF02888.11 AMD22942.1 - 0.51 10.1 5.0 0.19 11.5 0.3 2.5 3 1 0 3 3 3 0 Calmodulin binding domain SpecificRecomb PF10136.4 AMD22942.1 - 1.2 7.1 5.3 1.5 6.8 3.7 1.1 1 0 0 1 1 1 0 Site-specific recombinase Peptidase_S46 PF10459.4 AMD22942.1 - 2.5 6.4 14.7 7.7 4.7 10.2 1.6 1 1 0 1 1 1 0 Peptidase S46 MerR-DNA-bind PF09278.6 AMD22942.1 - 3.5 8.0 5.6 20 5.6 0.2 3.6 3 1 0 3 3 3 0 MerR, DNA binding DUF2072 PF09845.4 AMD22942.1 - 3.6 7.5 9.9 0.31 10.9 0.8 2.7 2 2 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) Sec20 PF03908.8 AMD22942.1 - 9.2 6.0 12.8 0.47 10.1 1.3 3.5 1 1 4 5 5 5 0 Sec20 AAA PF00004.24 AMD22943.1 - 4.6e-41 140.1 0.0 9.6e-41 139.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 AMD22943.1 - 6e-06 26.3 0.2 0.0021 18.1 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.9 AMD22943.1 - 2.2e-05 24.4 0.1 0.00013 21.9 0.0 2.2 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 AMD22943.1 - 0.00011 21.9 2.3 0.0003 20.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 AMD22943.1 - 0.00026 20.1 0.0 0.00053 19.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 AMD22943.1 - 0.0014 18.7 1.8 0.012 15.6 0.1 2.7 2 1 0 2 2 2 1 AAA domain PhoH PF02562.11 AMD22943.1 - 0.004 16.3 0.1 0.022 14.0 0.1 2.0 2 0 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.1 AMD22943.1 - 0.0062 16.2 0.1 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain DUF815 PF05673.8 AMD22943.1 - 0.0064 15.4 0.0 0.012 14.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 AMD22943.1 - 0.0094 16.7 0.1 0.03 15.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.16 AMD22943.1 - 0.0094 15.1 0.2 0.025 13.7 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 AMD22943.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.1 AMD22943.1 - 0.018 14.9 0.0 0.051 13.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.1 AMD22943.1 - 0.02 14.3 0.5 0.19 11.1 0.1 2.2 1 1 1 2 2 2 0 AAA domain BLOC1_2 PF10046.4 AMD22943.1 - 0.034 14.2 1.1 0.14 12.2 0.7 2.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_11 PF13086.1 AMD22943.1 - 0.038 13.5 0.2 0.12 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 AMD22943.1 - 0.05 13.4 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 AMD22943.1 - 0.057 12.9 0.1 0.16 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 AMD22943.1 - 0.075 12.1 0.1 0.16 11.0 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.17 AMD22943.1 - 0.077 13.1 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase WD40 PF00400.27 AMD22944.1 - 1.9e-45 151.1 13.3 3e-11 42.7 0.1 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 AMD22944.1 - 0.026 12.6 0.2 6.9 4.6 0.0 3.0 1 1 1 3 3 3 0 Nucleoporin Nup120/160 Nbas_N PF15492.1 AMD22944.1 - 0.035 13.2 0.0 8.5 5.3 0.0 2.4 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal SURF2 PF05477.6 AMD22944.1 - 0.082 12.0 0.4 0.15 11.2 0.3 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) A_deaminase PF00962.17 AMD22945.1 - 1.1e-113 379.5 0.1 1.5e-113 379.0 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase zf-DHHC PF01529.15 AMD22946.1 - 3.1e-28 98.3 1.3 3.1e-28 98.3 0.9 2.4 2 1 1 3 3 3 1 DHHC palmitoyltransferase MAT1 PF06391.8 AMD22947.1 - 1.7e-55 187.7 30.2 2e-55 187.4 20.9 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_3 PF13920.1 AMD22947.1 - 0.0022 17.6 4.9 0.0038 16.8 3.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 AMD22947.1 - 0.003 17.5 6.0 0.0081 16.1 4.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 AMD22947.1 - 0.007 16.0 5.5 0.026 14.1 3.9 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 AMD22947.1 - 0.0071 16.1 5.8 0.014 15.2 4.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-piccolo PF05715.8 AMD22947.1 - 0.088 12.8 1.1 0.19 11.7 0.8 1.5 1 0 0 1 1 1 0 Piccolo Zn-finger zf-RING_5 PF14634.1 AMD22947.1 - 0.096 12.4 9.1 0.77 9.5 6.2 2.2 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.1 AMD22947.1 - 0.36 10.5 4.0 0.95 9.2 2.7 1.8 1 0 0 1 1 1 0 RING-type zinc-finger 3HCDH_N PF02737.13 AMD22947.1 - 0.41 10.2 4.9 0.69 9.5 3.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-RING_4 PF14570.1 AMD22947.1 - 1.2 8.7 9.7 11 5.6 6.7 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain CGI-121 PF08617.5 AMD22948.1 - 9.5e-38 129.3 0.7 1.1e-37 129.2 0.5 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Sel1 PF08238.7 AMD22949.1 - 2.4e-36 123.3 17.6 3.2e-07 30.7 0.1 8.1 7 1 0 7 7 7 7 Sel1 repeat DUF3767 PF12597.3 AMD22950.1 - 6.8e-42 141.8 0.1 1.1e-41 141.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) YrhK PF14145.1 AMD22950.1 - 0.056 13.1 0.4 0.089 12.4 0.3 1.3 1 0 0 1 1 1 0 YrhK-like protein DUF3353 PF11833.3 AMD22950.1 - 0.18 11.2 2.1 0.16 11.3 0.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3353) LigB PF02900.13 AMD22951.1 - 8e-33 113.5 0.0 1.1e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Sgf11 PF08209.6 AMD22952.1 - 0.18 11.1 0.3 0.37 10.1 0.0 1.6 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Cupin_8 PF13621.1 AMD22952.1 - 1.8 8.0 7.5 1 8.8 2.0 2.2 1 1 1 2 2 2 0 Cupin-like domain Ribosomal_L10 PF00466.15 AMD22953.1 - 2.4e-07 30.5 0.0 4.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Methyltransf_4 PF02390.12 AMD22954.1 - 8.4e-60 201.2 0.1 1.4e-59 200.5 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 AMD22954.1 - 4.4e-05 24.0 0.0 7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AMD22954.1 - 0.00045 19.8 0.0 0.00073 19.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AMD22954.1 - 0.00058 19.8 0.0 0.00094 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AMD22954.1 - 0.0032 16.8 0.0 0.01 15.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 AMD22954.1 - 0.0055 17.0 0.0 0.015 15.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 AMD22954.1 - 0.0096 15.0 0.1 0.02 13.9 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family DOT1 PF08123.8 AMD22954.1 - 0.018 14.3 0.0 0.042 13.1 0.0 1.6 2 0 0 2 2 2 0 Histone methylation protein DOT1 Mito_carr PF00153.22 AMD22955.1 - 4.9e-29 99.8 0.5 1e-14 53.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CFIA_Pcf11 PF11526.3 AMD22956.1 - 1.1e-24 86.3 5.1 1.1e-24 86.3 3.5 2.7 2 0 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 Activator_LAG-3 PF11498.3 AMD22956.1 - 1.9 7.1 48.3 3.6 6.2 33.5 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Sec34 PF04136.10 AMD22957.1 - 0.0088 15.7 1.2 0.0088 15.7 0.8 3.1 2 1 1 3 3 3 1 Sec34-like family Spc7 PF08317.6 AMD22957.1 - 0.25 9.9 30.3 0.038 12.6 1.9 3.6 1 1 2 3 3 3 0 Spc7 kinetochore protein HrpB7 PF09486.5 AMD22957.1 - 4 7.3 12.4 0.22 11.4 2.1 3.0 2 2 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF2636 PF11120.3 AMD22958.1 - 0.23 10.9 0.0 0.61 9.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2636) ADK PF00406.17 AMD22959.1 - 7.3e-61 204.4 0.0 8.6e-61 204.2 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 AMD22959.1 - 1.5e-14 53.3 0.0 3.5e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 AMD22959.1 - 7.7e-06 25.8 0.0 1.4e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AMD22959.1 - 0.00023 21.9 0.0 0.00042 21.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AMD22959.1 - 0.0043 17.3 0.0 0.008 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 AMD22959.1 - 0.057 12.9 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 AMD22959.1 - 0.11 11.6 0.0 0.18 10.8 0.0 1.5 1 1 0 1 1 1 0 Zeta toxin zf-C2H2 PF00096.21 AMD22960.1 - 8.5e-12 44.6 9.1 2.3e-05 24.4 0.7 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD22960.1 - 2.7e-08 33.7 13.6 3.1e-06 27.1 0.3 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 AMD22960.1 - 9.8e-08 31.8 8.5 0.0015 18.7 0.7 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 AMD22960.1 - 0.00054 20.0 9.8 0.021 15.0 0.2 3.0 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-Di19 PF05605.7 AMD22960.1 - 0.0081 16.2 1.8 0.56 10.3 0.0 2.6 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 AMD22960.1 - 0.073 13.2 8.6 1 9.6 0.3 3.0 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 AMD22960.1 - 0.14 12.4 8.8 0.35 11.1 1.1 3.0 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.2 AMD22960.1 - 0.42 10.7 6.3 3.9 7.6 0.5 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.4 AMD22960.1 - 0.64 9.8 3.6 2 8.2 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_6 PF13912.1 AMD22960.1 - 1 9.3 5.5 1.1 9.2 0.2 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger UPF0547 PF10571.4 AMD22960.1 - 1.4 8.6 4.9 0.92 9.2 0.5 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-C2HC_2 PF13913.1 AMD22960.1 - 3.5 7.4 6.6 16 5.2 0.6 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-BED PF02892.10 AMD22960.1 - 3.6 7.4 7.4 1.1 9.0 0.3 2.4 1 1 1 2 2 2 0 BED zinc finger Histone PF00125.19 AMD22962.1 - 3.5e-26 91.1 0.0 4.8e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 AMD22962.1 - 4.1e-06 26.7 0.0 6.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 AMD22963.1 - 2.4e-22 78.8 0.3 3.5e-22 78.3 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 AMD22963.1 - 7.6e-06 25.9 0.1 7.6e-06 25.9 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 AMD22963.1 - 0.0015 18.7 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 AMD22963.1 - 0.033 12.8 3.3 0.043 12.4 2.3 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF601 PF04642.7 AMD22963.1 - 0.33 10.2 6.4 0.39 10.0 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 RNA_pol_Rpb2_1 PF04563.10 AMD22963.1 - 1.3 7.8 5.3 4.3 6.2 1.3 2.0 1 1 1 2 2 2 0 RNA polymerase beta subunit VIT1 PF01988.14 AMD22964.1 - 1.9e-55 187.6 1.4 2.3e-55 187.4 1.0 1.1 1 0 0 1 1 1 1 VIT family Rsa3 PF14615.1 AMD22965.1 - 9.3e-22 76.0 0.1 1.6e-21 75.2 0.1 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 SR-25 PF10500.4 AMD22965.1 - 0.0028 17.1 8.4 0.004 16.6 5.8 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IFT43 PF15305.1 AMD22965.1 - 0.1 12.6 6.5 0.15 12.0 4.5 1.2 1 0 0 1 1 1 0 Intraflagellar transport protein 43 WD40 PF00400.27 AMD22966.1 - 3.8e-60 197.7 23.0 2.1e-08 33.7 0.0 11.3 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp13 PF08625.6 AMD22966.1 - 1.9e-48 163.6 1.1 3.3e-48 162.9 0.7 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 AMD22966.1 - 1e-07 30.5 11.9 0.19 9.8 0.5 6.4 4 1 2 7 7 7 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 AMD22966.1 - 0.00056 18.7 3.2 0.092 11.4 0.0 3.7 2 1 2 4 4 4 2 Nup133 N terminal like Imm29 PF15575.1 AMD22966.1 - 0.015 14.9 0.4 0.048 13.2 0.2 1.9 1 1 0 1 1 1 0 Immunity protein 29 CRF1 PF10380.4 AMD22967.1 - 3.9e-31 107.9 2.8 3.9e-31 107.9 1.9 3.2 3 0 0 3 3 3 1 Transcription factor CRF1 PRKCSH-like PF12999.2 AMD22968.1 - 3.5e-47 160.2 4.3 6.4e-47 159.3 2.2 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 AMD22968.1 - 8.9e-20 70.7 0.8 1.5e-18 66.7 0.0 3.1 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein Syntaxin PF00804.20 AMD22968.1 - 1.6e-05 24.9 6.0 0.0012 19.0 0.1 2.7 2 1 0 2 2 2 2 Syntaxin Herpes_UL6 PF01763.11 AMD22968.1 - 0.0081 14.3 1.0 0.014 13.5 0.0 1.8 2 0 0 2 2 2 1 Herpesvirus UL6 like HALZ PF02183.13 AMD22968.1 - 0.044 13.5 2.2 4.3 7.1 0.3 3.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper Phytoreo_P8 PF07124.6 AMD22968.1 - 0.047 12.3 0.1 0.074 11.7 0.1 1.2 1 0 0 1 1 1 0 Phytoreovirus outer capsid protein P8 FlxA PF14282.1 AMD22968.1 - 0.12 12.3 1.1 1 9.3 0.3 2.5 2 0 0 2 2 2 0 FlxA-like protein Cep57_CLD_2 PF14197.1 AMD22968.1 - 0.12 12.3 5.8 0.094 12.6 0.5 3.0 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 Ldl_recept_a PF00057.13 AMD22968.1 - 0.59 10.0 18.7 2.7 7.9 3.3 2.7 1 1 1 2 2 2 0 Low-density lipoprotein receptor domain class A Prefoldin_2 PF01920.15 AMD22968.1 - 1.2 8.9 6.4 6.6 6.5 0.6 2.9 2 0 0 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.3 AMD22968.1 - 1.8 8.4 7.3 0.53 10.1 1.6 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding F-box-like PF12937.2 AMD22969.1 - 2.3e-07 30.4 0.1 4.4e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 AMD22969.1 - 1.6e-06 27.6 0.0 2.9e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 F-box domain PRANC PF09372.5 AMD22969.1 - 0.031 14.2 0.1 0.074 13.0 0.1 1.6 1 0 0 1 1 1 0 PRANC domain PBP1_TM PF14812.1 AMD22969.1 - 9.4 6.6 8.3 0.57 10.5 0.9 2.5 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cyclin_N PF00134.18 AMD22970.1 - 0.062 12.8 3.7 0.28 10.7 2.5 2.0 1 1 0 1 1 1 0 Cyclin, N-terminal domain Septin PF00735.13 AMD22971.1 - 5.8e-83 278.1 3.9 9.5e-82 274.1 2.7 2.0 1 1 0 1 1 1 1 Septin Dynamin_N PF00350.18 AMD22971.1 - 0.00025 20.9 0.0 0.00066 19.5 0.0 1.7 1 0 0 1 1 1 1 Dynamin family AAA_17 PF13207.1 AMD22971.1 - 0.00034 21.4 0.0 0.0025 18.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 AMD22971.1 - 0.00087 18.2 0.0 0.0017 17.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 AMD22971.1 - 0.0013 18.8 0.0 0.0044 17.1 0.0 1.8 1 1 1 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 AMD22971.1 - 0.004 17.1 0.0 0.011 15.6 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 AMD22971.1 - 0.004 16.6 0.0 0.0073 15.8 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family Miro PF08477.8 AMD22971.1 - 0.0054 17.2 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 AMD22971.1 - 0.0054 16.2 0.1 0.13 11.7 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.15 AMD22971.1 - 0.0072 15.0 0.8 0.075 11.7 0.0 2.4 2 1 0 2 2 2 1 G-protein alpha subunit AAA_10 PF12846.2 AMD22971.1 - 0.0079 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain ABC_tran PF00005.22 AMD22971.1 - 0.0081 16.4 0.1 0.022 15.0 0.1 1.8 1 1 0 1 1 1 1 ABC transporter Pox_A32 PF04665.7 AMD22971.1 - 0.0082 15.4 0.0 0.018 14.3 0.0 1.5 1 0 0 1 1 1 1 Poxvirus A32 protein MobB PF03205.9 AMD22971.1 - 0.0093 15.6 0.0 0.025 14.2 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 AMD22971.1 - 0.011 15.1 0.1 0.055 12.8 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 AMD22971.1 - 0.013 15.8 0.1 0.044 14.0 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.1 AMD22971.1 - 0.013 15.3 0.0 0.075 12.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 AMD22971.1 - 0.024 14.2 0.0 0.057 13.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain GTP_EFTU PF00009.22 AMD22971.1 - 0.068 12.5 0.3 1.6 8.1 0.0 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Arch_ATPase PF01637.13 AMD22971.1 - 0.071 12.7 0.1 0.16 11.6 0.0 1.6 2 0 0 2 2 1 0 Archaeal ATPase AAA_23 PF13476.1 AMD22971.1 - 0.66 10.2 4.8 1.7 8.9 3.0 2.1 1 1 0 1 1 1 0 AAA domain Rad9_Rad53_bind PF08605.5 AMD22973.1 - 3.1e-37 127.2 0.1 1.3e-36 125.2 0.1 2.2 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.21 AMD22973.1 - 4.9e-11 42.6 0.3 1.3e-10 41.2 0.2 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain zf-C2H2 PF00096.21 AMD22974.1 - 1.3e-11 44.1 7.3 3.5e-05 23.8 0.2 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AMD22974.1 - 6e-08 32.6 5.3 1.7e-06 28.0 1.1 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 AMD22974.1 - 1.9e-07 30.9 7.3 0.006 16.8 0.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AMD22974.1 - 9.3e-07 28.5 2.8 0.021 14.6 0.6 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 AMD22974.1 - 9.5e-05 22.4 1.6 0.61 10.3 0.5 3.0 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AMD22974.1 - 0.0056 16.7 0.9 1.6 8.9 0.0 2.9 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding Aha1_N PF09229.6 AMD22975.1 - 1.2e-38 131.9 0.0 2.8e-38 130.8 0.0 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 AMD22975.1 - 2.8e-10 40.3 0.0 5e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DAP3 PF10236.4 AMD22975.1 - 0.067 12.1 0.0 0.1 11.4 0.0 1.3 1 1 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Fungal_trans_2 PF11951.3 AMD22976.1 - 3.9e-11 42.1 0.3 3.9e-11 42.1 0.2 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 AMD22976.1 - 1.3e-09 37.8 13.3 2.3e-09 36.9 9.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cpn60_TCP1 PF00118.19 AMD22977.1 - 5e-144 480.5 14.1 5.8e-144 480.3 9.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ras PF00071.17 AMD22978.1 - 3e-51 173.0 0.0 3.6e-51 172.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 AMD22978.1 - 9.7e-14 51.8 0.0 1.3e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 AMD22978.1 - 1.3e-07 31.0 0.0 1.7e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family W2 PF02020.13 AMD22979.1 - 5.4e-16 58.3 1.2 2e-15 56.5 0.8 2.0 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.18 AMD22979.1 - 1.5e-11 44.0 0.0 3.6e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 AMD22979.1 - 2.8e-11 42.3 13.1 0.0004 19.7 0.2 4.3 1 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 AMD22979.1 - 5.1e-06 25.9 9.5 0.02 14.4 0.2 3.5 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.2 AMD22979.1 - 0.0024 17.9 0.0 0.007 16.4 0.0 1.7 2 0 0 2 2 2 1 MobA-like NTP transferase domain DUF2340 PF10209.4 AMD22980.1 - 3.6e-55 185.3 3.4 4.2e-55 185.1 2.3 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Peptidase_C13 PF01650.13 AMD22980.1 - 0.00022 20.6 0.3 0.00027 20.3 0.2 1.0 1 0 0 1 1 1 1 Peptidase C13 family RDV-p3 PF09231.5 AMD22980.1 - 0.044 11.1 0.0 0.052 10.9 0.0 1.0 1 0 0 1 1 1 0 Rice dwarf virus p3 DUF676 PF05057.9 AMD22981.1 - 1.1e-41 142.5 0.3 2e-41 141.7 0.2 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 AMD22981.1 - 0.001 18.6 0.0 0.0024 17.4 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein SecE PF00584.15 AMD22981.1 - 0.005 16.3 0.7 0.0091 15.5 0.5 1.4 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex UXS1_N PF11803.3 AMD22981.1 - 0.093 12.4 0.3 0.29 10.9 0.0 1.9 2 0 0 2 2 2 0 UDP-glucuronate decarboxylase N-terminal Pkinase PF00069.20 AMD22983.1 - 5.2e-52 176.5 0.0 6.5e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AMD22983.1 - 1.6e-15 56.9 0.0 2.6e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AMD22983.1 - 3.9e-07 30.0 0.0 1.2e-06 28.5 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 AMD22983.1 - 0.0026 17.3 0.0 0.0051 16.3 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Ribosomal_L3 PF00297.17 AMD22984.1 - 7.4e-122 405.7 9.5 8.9e-122 405.5 6.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 PHD PF00628.24 AMD22985.1 - 6.5e-08 32.1 8.1 6.5e-08 32.1 5.6 1.7 1 1 1 2 2 2 1 PHD-finger FANCL_C PF11793.3 AMD22985.1 - 0.022 14.7 1.3 0.052 13.5 0.9 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.1 AMD22985.1 - 0.037 14.0 2.5 0.069 13.1 1.7 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 AMD22985.1 - 0.04 14.0 3.4 0.071 13.2 2.4 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain ING PF12998.2 AMD22985.1 - 0.048 13.9 0.2 1.1 9.5 0.1 2.3 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding DUF1835 PF08874.5 AMD22985.1 - 0.068 13.1 0.0 0.33 10.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1835) Ecl1 PF12855.2 AMD22985.1 - 0.51 9.6 6.1 0.058 12.6 1.4 1.6 2 0 0 2 2 2 0 Life-span regulatory factor zf-RING-like PF08746.6 AMD22985.1 - 2 8.4 4.9 4.4 7.3 3.4 1.7 1 0 0 1 1 1 0 RING-like domain PHD_2 PF13831.1 AMD22985.1 - 3.6 6.9 9.9 2.3 7.5 2.5 2.4 2 0 0 2 2 2 0 PHD-finger DUF2116 PF09889.4 AMD22985.1 - 7.3 6.4 6.5 1.3 8.8 1.7 1.9 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Gln-synt_C PF00120.19 AMD22986.1 - 3.4e-63 213.2 0.0 4.2e-63 212.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 AMD22986.1 - 7.4e-20 70.3 0.0 1.2e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.9 AMD22987.1 - 7e-57 192.9 5.9 7e-57 192.9 4.1 1.9 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 AMD22987.1 - 1.4e-39 134.7 1.8 1.4e-39 134.7 1.2 2.8 4 0 0 4 4 4 1 V-ATPase subunit H HEAT_2 PF13646.1 AMD22987.1 - 0.035 14.4 0.1 7.1 6.9 0.0 3.3 2 1 0 2 2 2 0 HEAT repeats Syntaxin PF00804.20 AMD22988.1 - 0.049 13.8 1.2 0.11 12.6 0.8 1.6 1 0 0 1 1 1 0 Syntaxin Mnd1 PF03962.10 AMD22988.1 - 0.06 13.0 2.1 0.092 12.3 1.4 1.3 1 0 0 1 1 1 0 Mnd1 family IncA PF04156.9 AMD22988.1 - 0.07 12.7 0.6 0.097 12.2 0.4 1.3 1 0 0 1 1 1 0 IncA protein MerR-DNA-bind PF09278.6 AMD22988.1 - 0.13 12.7 1.2 6.3 7.2 0.4 2.5 2 0 0 2 2 2 0 MerR, DNA binding DUF641 PF04859.7 AMD22988.1 - 0.14 11.9 2.5 0.11 12.2 0.3 1.9 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) YlqD PF11068.3 AMD22988.1 - 0.2 11.7 3.1 0.39 10.7 2.2 1.5 1 0 0 1 1 1 0 YlqD protein Lge1 PF11488.3 AMD22988.1 - 0.28 11.4 5.6 0.081 13.1 0.8 2.4 2 1 1 3 3 3 0 Transcriptional regulatory protein LGE1 V-SNARE PF05008.10 AMD22988.1 - 0.46 10.6 3.8 3.5 7.8 2.4 2.4 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus PCI PF01399.22 AMD22989.1 - 0.00021 21.5 0.0 0.00062 20.0 0.0 1.9 1 1 0 1 1 1 1 PCI domain Sel1 PF08238.7 AMD22989.1 - 0.024 15.2 0.7 0.024 15.2 0.5 2.1 2 0 0 2 2 2 0 Sel1 repeat TPR_12 PF13424.1 AMD22989.1 - 0.029 14.2 0.6 0.15 12.0 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Tmemb_14 PF03647.8 AMD22990.1 - 5.1e-23 81.3 5.6 6.1e-23 81.0 3.9 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF2416 PF10315.4 AMD22990.1 - 0.00061 20.0 1.7 0.0007 19.8 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2416) DUF4131 PF13567.1 AMD22990.1 - 0.61 9.4 3.7 7.5 5.9 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) G-gamma PF00631.17 AMD22991.1 - 5.3e-27 93.3 0.1 6.4e-27 93.0 0.0 1.1 1 0 0 1 1 1 1 GGL domain Evr1_Alr PF04777.8 AMD22992.1 - 2.3e-25 88.2 0.1 3.4e-25 87.7 0.1 1.2 1 0 0 1 1 1 1 Erv1 / Alr family Herpes_UL69 PF05459.7 AMD22992.1 - 0.078 12.1 0.0 0.72 8.9 0.0 2.0 1 1 1 2 2 2 0 Herpesvirus transcriptional regulator family TIP41 PF04176.8 AMD22993.1 - 7.1e-73 243.7 2.1 1.1e-72 243.1 1.5 1.3 1 0 0 1 1 1 1 TIP41-like family TPR_1 PF00515.23 AMD22994.1 - 6.3e-05 22.4 0.0 0.12 12.0 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 AMD22994.1 - 0.0001 21.9 0.2 0.015 15.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 AMD22994.1 - 0.00025 20.5 0.3 0.0051 16.4 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 AMD22994.1 - 0.00086 18.9 0.1 0.026 14.1 0.1 2.8 2 1 1 3 3 3 2 TPR repeat APG17 PF04108.7 AMD22994.1 - 0.024 13.4 0.5 0.086 11.6 0.2 1.8 1 1 0 2 2 2 0 Autophagy protein Apg17 TPR_14 PF13428.1 AMD22994.1 - 0.062 13.9 0.1 0.68 10.7 0.0 2.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 AMD22994.1 - 0.11 12.3 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat eIF-5_eIF-2B PF01873.12 AMD22995.1 - 9e-41 138.4 0.0 1.7e-40 137.5 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.13 AMD22995.1 - 8.5e-27 92.9 2.1 3.2e-26 91.0 0.0 2.5 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon F-box-like PF12937.2 AMD22997.1 - 1.7e-06 27.6 0.1 3.5e-06 26.6 0.1 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 AMD22997.1 - 0.0003 20.3 6.4 1.4 8.6 0.2 5.8 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) Nucleoporin_C PF03177.9 AMD22998.1 - 6.7e-135 450.8 14.1 8.9e-135 450.4 9.8 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 AMD22998.1 - 7.6e-115 384.0 9.5 1.4e-114 383.1 6.6 1.5 1 0 0 1 1 1 1 Nup133 N terminal like Atg8 PF02991.11 AMD22999.1 - 5.9e-48 161.1 0.1 6.7e-48 160.9 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 AMD22999.1 - 1.5e-07 31.5 0.0 1.8e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Mem_trans PF03547.13 AMD22999.1 - 0.11 10.7 0.0 0.14 10.4 0.0 1.1 1 0 0 1 1 1 0 Membrane transport protein YtxH PF12732.2 AMD23000.1 - 0.11 12.8 1.6 0.12 12.7 1.1 1.1 1 0 0 1 1 1 0 YtxH-like protein MT0933_antitox PF14013.1 AMD23000.1 - 0.24 11.5 7.8 0.33 11.0 5.4 1.3 1 0 0 1 1 1 0 MT0933-like antitoxin protein SRP40_C PF05022.7 AMD23001.1 - 1.2e-29 102.5 4.3 2.6e-29 101.5 3.0 1.6 1 0 0 1 1 1 1 SRP40, C-terminal domain Helicase_C_3 PF13625.1 AMD23002.1 - 1e-25 89.9 0.0 3.6e-25 88.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AMD23002.1 - 1.1e-13 51.4 0.0 2.3e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 AMD23002.1 - 6.6e-12 44.8 0.1 9.9e-12 44.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 AMD23002.1 - 1.2e-10 41.1 0.0 3.2e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AMD23002.1 - 7.6e-07 28.7 0.0 1.3e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.1 AMD23002.1 - 0.018 14.4 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein CheY-binding PF09078.6 AMD23002.1 - 0.51 10.3 2.6 9.7 6.2 0.7 2.9 2 0 0 2 2 2 0 CheY binding Ndc80_HEC PF03801.8 AMD23003.1 - 1.2e-55 187.2 5.8 1.8e-55 186.7 0.1 2.4 2 0 0 2 2 2 1 HEC/Ndc80p family Spc7 PF08317.6 AMD23003.1 - 0.00012 20.8 45.4 0.011 14.4 16.5 3.2 2 1 1 3 3 3 2 Spc7 kinetochore protein Cluap1 PF10234.4 AMD23003.1 - 2.6 7.1 0.0 2.6 7.1 0.0 5.5 5 2 1 6 6 6 0 Clusterin-associated protein-1 FliJ PF02050.11 AMD23003.1 - 8.4 6.4 45.9 1.9 8.5 7.5 3.9 3 2 1 4 4 4 0 Flagellar FliJ protein Pantoate_ligase PF02569.10 AMD23004.1 - 9.8e-105 349.3 0.0 1.1e-104 349.1 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Myosin_TH1 PF06017.8 AMD23004.1 - 0.023 13.9 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 Myosin tail FAD_syn PF06574.7 AMD23004.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 FAD synthetase SPOC PF07744.8 AMD23005.1 - 0.002 18.5 0.1 3.2 8.2 0.0 2.5 2 0 0 2 2 2 2 SPOC domain HATPase_c PF02518.21 AMD23006.1 - 2.6e-26 91.5 0.4 1.2e-25 89.3 0.2 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 AMD23006.1 - 4.5e-26 91.0 0.3 8.7e-26 90.1 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 AMD23006.1 - 3.6e-11 42.8 0.2 9.9e-11 41.4 0.0 1.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 AMD23006.1 - 1.2e-08 35.0 0.5 0.00011 22.2 0.1 2.9 2 0 0 2 2 2 2 HAMP domain Alpha-2-MRAP_C PF06401.6 AMD23006.1 - 0.024 14.4 0.1 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain ubiquitin PF00240.18 AMD23007.1 - 2.9e-33 113.0 0.7 4.1e-33 112.5 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.12 AMD23007.1 - 4.9e-30 102.8 11.7 8e-30 102.2 8.1 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.3 AMD23007.1 - 1.2e-18 66.5 0.6 1.9e-18 65.8 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 AMD23007.1 - 0.00026 21.1 0.2 0.0011 19.2 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 AMD23007.1 - 0.002 17.8 0.0 0.0031 17.2 0.0 1.2 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 AMD23007.1 - 0.027 14.3 0.0 0.049 13.5 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 AMD23007.1 - 0.031 14.4 0.1 0.038 14.1 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Fer2_3 PF13085.1 AMD23007.1 - 0.19 11.5 1.1 0.56 10.0 0.7 1.8 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain TPR_MLP1_2 PF07926.7 AMD23008.1 - 3.5e-27 94.7 24.4 3.5e-27 94.7 16.9 17.7 4 4 12 17 17 17 7 TPR/MLP1/MLP2-like protein Filament PF00038.16 AMD23008.1 - 0.0039 16.7 10.0 0.0039 16.7 6.9 11.8 2 1 9 12 12 12 5 Intermediate filament protein zf-primase PF09329.6 AMD23009.1 - 2.3e-11 43.0 0.4 4.4e-11 42.1 0.3 1.5 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.20 AMD23009.1 - 0.02 14.7 0.0 0.043 13.6 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DAGK_cat PF00781.19 AMD23010.1 - 2.9e-07 29.9 0.0 4.8e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pcc1 PF09341.5 AMD23011.1 - 1.1e-22 79.8 0.0 1.2e-22 79.6 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 PIN_4 PF13638.1 AMD23012.1 - 1.3e-11 44.6 0.1 1.3e-11 44.6 0.1 2.4 2 0 0 2 2 2 1 PIN domain PEPCK_ATP PF01293.15 AMD23014.1 - 2.5e-218 725.2 0.0 3.2e-218 724.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 AMD23014.1 - 0.023 14.5 0.1 0.15 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain PTPA PF03095.10 AMD23015.1 - 2.5e-102 342.0 0.0 2.9e-102 341.8 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DAO PF01266.19 AMD23017.1 - 8.2e-53 179.5 0.0 1.1e-52 179.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AMD23017.1 - 1.7e-12 46.9 3.6 8.1e-12 44.7 2.5 1.8 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 AMD23017.1 - 1.8e-09 37.1 4.5 4.9e-08 32.4 3.1 2.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 AMD23017.1 - 6.2e-05 22.9 0.1 0.00061 19.7 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 AMD23017.1 - 6.8e-05 21.9 0.8 0.0033 16.3 0.3 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.12 AMD23017.1 - 0.00017 20.7 0.2 0.049 12.7 0.0 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.14 AMD23017.1 - 0.00034 19.7 0.1 0.029 13.4 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 AMD23017.1 - 0.0006 18.3 0.7 0.00095 17.7 0.5 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.1 AMD23017.1 - 0.00076 19.4 0.8 0.0023 17.9 0.6 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.13 AMD23017.1 - 0.026 14.1 1.8 0.095 12.3 1.2 2.0 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 AMD23017.1 - 0.056 12.3 0.1 0.28 10.0 0.1 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.22 AMD23017.1 - 0.098 13.0 0.3 0.26 11.7 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 AMD23017.1 - 0.1 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding UCH PF00443.24 AMD23018.1 - 4.1e-55 186.7 5.7 4.1e-55 186.7 3.9 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 AMD23018.1 - 2.8e-24 86.0 5.0 2.8e-24 86.0 3.4 2.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 AMD23018.1 - 0.00077 19.7 0.0 0.002 18.4 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Galactosyl_T PF01762.16 AMD23018.1 - 0.06 12.9 0.3 0.39 10.3 0.0 2.2 2 0 0 2 2 2 0 Galactosyltransferase Myb_DNA-bind_6 PF13921.1 AMD23019.1 - 6.5e-26 90.2 3.8 5.5e-10 39.2 0.0 4.0 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 AMD23019.1 - 5.4e-21 74.3 7.9 3.4e-09 36.6 0.3 4.0 3 1 0 3 3 3 3 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.4 AMD23019.1 - 0.99 9.6 6.1 2.5 8.3 0.1 3.7 4 0 0 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF1748 PF08520.5 AMD23020.1 - 5.9e-29 99.5 0.1 6.5e-29 99.3 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Coa1 PF08695.5 AMD23021.1 - 2.7e-37 126.8 0.0 3.4e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 SKG6 PF08693.5 AMD23022.1 - 0.11 11.8 3.3 0.21 10.9 2.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain FH2 PF02181.18 AMD23023.1 - 2.1e-64 217.7 13.5 2.1e-64 217.7 9.3 2.5 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.8 AMD23023.1 - 3.8e-10 39.4 0.2 3.8e-10 39.4 0.2 3.1 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain LTXXQ PF07813.7 AMD23023.1 - 0.015 15.7 1.4 0.015 15.7 1.0 2.4 2 0 0 2 2 2 0 LTXXQ motif family protein DUF3373 PF11853.3 AMD23023.1 - 0.095 11.2 1.4 0.17 10.3 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Thiolase_N PF00108.18 AMD23024.1 - 4.8e-82 274.8 0.4 6.8e-82 274.3 0.3 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 AMD23024.1 - 1.4e-48 163.4 0.8 3e-48 162.2 0.5 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 AMD23024.1 - 0.00059 19.3 0.3 0.0014 18.1 0.1 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 AMD23024.1 - 0.38 10.4 4.0 2.2 7.9 0.1 3.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Aldo_ket_red PF00248.16 AMD23025.1 - 8.2e-39 133.1 0.1 1.5e-38 132.2 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Sugar_tr PF00083.19 AMD23026.1 - 8.2e-71 238.9 28.5 9.7e-71 238.6 19.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 AMD23026.1 - 2.8e-20 72.3 27.2 1.4e-19 69.9 14.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.15 AMD23026.1 - 0.0011 17.1 10.2 0.03 12.3 0.4 2.7 3 1 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Lig_chan PF00060.21 AMD23026.1 - 5.2 6.7 6.8 6.8 6.3 0.5 2.6 2 1 0 2 2 2 0 Ligand-gated ion channel Aldo_ket_red PF00248.16 AMD23027.1 - 2.7e-52 177.3 0.0 3.3e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family VAR1 PF05316.7 AMD23028.1 - 1e-32 113.1 54.9 7e-30 103.8 38.1 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal protein (VAR1) Ribosomal_S3_C PF00189.15 AMD23028.1 - 0.00085 19.4 3.3 0.00087 19.4 0.5 2.4 2 1 0 2 2 2 1 Ribosomal protein S3, C-terminal domain ATP-synt_C PF00137.16 AMD23029.1 - 1.8e-19 69.3 8.7 2.1e-19 69.1 6.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit C ABC2_membrane_4 PF12730.2 AMD23029.1 - 0.46 9.6 7.3 0.58 9.2 5.1 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein COX1 PF00115.15 AMD23030.1 - 9e-159 528.8 65.7 1.1e-158 528.5 45.6 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Fun_ATP-synt_8 PF05933.8 AMD23031.1 - 3.1e-21 75.1 10.6 3.3e-21 75.0 7.4 1.0 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) YMF19 PF02326.10 AMD23031.1 - 0.028 14.9 6.1 0.031 14.8 4.2 1.0 1 0 0 1 1 1 0 Plant ATP synthase F0 DUF3961 PF13106.1 AMD23031.1 - 0.069 12.7 3.2 0.1 12.2 2.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3961) ATP-synt_A PF00119.15 AMD23032.1 - 1.3e-53 181.6 37.9 1.7e-53 181.3 26.3 1.0 1 0 0 1 1 1 1 ATP synthase A chain Cytochrom_B_N_2 PF13631.1 AMD23033.1 - 2.6e-51 173.7 20.6 2.6e-51 173.7 14.3 2.9 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.12 AMD23033.1 - 2.7e-36 123.8 5.0 2.7e-36 123.8 3.5 3.9 2 1 2 4 4 4 1 Cytochrome b(C-terminal)/b6/petD Cytochrom_B_N PF00033.14 AMD23033.1 - 3.8e-15 55.7 17.5 3.8e-15 55.7 12.1 2.4 2 1 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB COX2 PF00116.15 AMD23034.1 - 3.4e-52 175.3 0.0 5.6e-52 174.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.10 AMD23034.1 - 6.1e-31 106.2 4.8 6.1e-31 106.2 3.3 1.8 2 0 0 2 2 2 1 Cytochrome C oxidase subunit II, transmembrane domain DUF1129 PF06570.6 AMD23034.1 - 2.5 7.3 5.8 3.4 6.9 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) COX3 PF00510.13 AMD23035.1 - 1.5e-104 349.0 31.9 1.7e-104 348.8 22.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III