# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- PWI PF01480.17 EWC43382.1 - 2.4e-11 43.8 1.9 4.1e-11 43.0 0.1 2.1 2 0 0 2 2 2 1 PWI domain zf-CCCH PF00642.24 EWC43382.1 - 2.6e-06 27.2 3.1 4.7e-06 26.4 3.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EWC43382.1 - 5e-06 26.2 0.0 1.7e-05 24.5 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EWC43382.1 - 1.8e-05 24.6 4.1 3.4e-05 23.7 4.1 1.5 1 0 0 1 1 1 1 Zinc finger domain Nup35_RRM_2 PF14605.6 EWC43382.1 - 4.8e-05 23.3 0.0 0.02 14.9 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PIN_12 PF16289.5 EWC43382.1 - 0.9 10.0 6.8 1.7 9.1 6.8 1.4 1 0 0 1 1 1 0 PIN domain IER PF05760.12 EWC43382.1 - 2 8.7 9.5 0.17 12.1 4.7 1.7 2 0 0 2 2 2 0 Immediate early response protein (IER) RRM_3 PF08777.11 EWC43382.1 - 2.2 8.4 14.8 0.31 11.1 0.1 2.7 1 1 0 2 2 2 0 RNA binding motif AAA_23 PF13476.6 EWC43382.1 - 3 8.3 10.5 4.8 7.6 10.5 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EWC43383.1 - 1.8e-34 119.0 2.4 2.4e-34 118.6 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EWC43383.1 - 1.8e-18 66.6 0.0 4.8e-18 65.2 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EWC43383.1 - 5.4e-10 39.5 12.1 7.7e-10 39.0 0.1 4.0 4 0 0 4 4 4 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EWC43383.1 - 1e-09 38.2 0.1 3.5e-09 36.5 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EWC43383.1 - 2.5e-07 30.7 0.4 4.9e-06 26.6 0.0 3.1 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 EWC43383.1 - 5.7e-05 23.3 0.0 0.00015 22.0 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EWC43383.1 - 0.0051 16.6 0.0 0.015 15.1 0.0 1.9 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Ras PF00071.22 EWC43383.1 - 0.043 13.4 0.0 0.22 11.1 0.0 2.4 1 1 0 1 1 1 0 Ras family AAA_22 PF13401.6 EWC43383.1 - 0.11 12.7 0.2 1.1 9.5 0.2 2.5 1 1 0 1 1 1 0 AAA domain Peptidase_S64 PF08192.11 EWC43384.1 - 0.057 11.9 0.1 0.16 10.4 0.0 1.7 2 0 0 2 2 2 0 Peptidase family S64 Abhydrolase_1 PF00561.20 EWC43385.1 - 1.2e-21 77.6 0.1 1.8e-21 77.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC43385.1 - 4.2e-16 58.9 0.0 7e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EWC43385.1 - 2e-12 48.2 1.2 3.5e-12 47.4 1.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EWC43385.1 - 4.5e-06 26.5 0.0 7.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase LIDHydrolase PF10230.9 EWC43385.1 - 0.0016 18.0 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ndr PF03096.14 EWC43385.1 - 0.015 14.1 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Ndr family Thioesterase PF00975.20 EWC43385.1 - 0.023 14.8 0.0 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 Thioesterase domain Lipase_3 PF01764.25 EWC43385.1 - 0.026 14.4 0.0 0.07 13.0 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) Chlorophyllase2 PF12740.7 EWC43385.1 - 0.051 12.5 0.0 0.071 12.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF915 PF06028.11 EWC43385.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_3 PF07859.13 EWC43385.1 - 0.072 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase PF07224.11 EWC43385.1 - 0.072 12.1 0.0 0.093 11.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_5 PF12695.7 EWC43385.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 EWC43385.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Nop PF01798.18 EWC43386.1 - 4e-62 209.7 0.0 5.3e-62 209.3 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin PGA2 PF07543.12 EWC43386.1 - 0.34 10.9 2.7 0.53 10.3 2.7 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 SUZ PF12752.7 EWC43387.1 - 3.3e-05 24.5 12.5 3.3e-05 24.5 12.5 3.3 1 1 1 2 2 2 1 SUZ domain Fe_hyd_lg_C PF02906.14 EWC43388.1 - 6e-50 170.2 0.0 1.1e-49 169.3 0.0 1.4 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain IF3_N PF05198.16 EWC43388.1 - 0.12 12.7 0.0 25 5.2 0.0 2.5 2 0 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain Arb1 PF09692.10 EWC43390.1 - 4.2e-101 339.0 0.0 1e-100 337.8 0.0 1.5 1 1 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 IPK PF03770.16 EWC43391.1 - 2.4e-57 194.0 0.0 2.9e-57 193.7 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase Nucleo_P87 PF07267.11 EWC43391.1 - 0.092 11.6 1.4 0.12 11.2 1.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RXT2_N PF08595.11 EWC43391.1 - 0.26 11.3 3.1 0.39 10.7 3.1 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 EWC43391.1 - 0.71 9.5 3.8 1.1 8.9 3.8 1.2 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 EWC43391.1 - 1.4 6.9 3.1 1.9 6.5 3.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Roughex PF06020.11 EWC43391.1 - 2.8 6.9 5.0 4.2 6.4 5.0 1.2 1 0 0 1 1 1 0 Drosophila roughex protein NOA36 PF06524.12 EWC43391.1 - 3.6 6.8 5.7 5 6.4 5.7 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 EWC43391.1 - 4 7.7 11.8 2.5 8.4 10.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 EWC43391.1 - 4.1 5.4 8.2 5.5 5.0 8.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Het-C PF07217.11 EWC43392.1 - 3.7e-245 814.8 0.0 4.5e-245 814.5 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Hid1 PF12722.7 EWC43393.1 - 3.8e-284 944.9 0.0 5.3e-284 944.4 0.0 1.2 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EWC43393.1 - 4.3e-109 365.7 0.0 4.7e-109 365.6 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein DUF913 PF06025.12 EWC43393.1 - 0.038 13.0 0.9 0.078 11.9 0.9 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RDM PF11002.8 EWC43393.1 - 0.14 12.2 0.6 0.33 11.0 0.6 1.6 1 0 0 1 1 1 0 RFPL defining motif (RDM) DUF3484 PF11983.8 EWC43393.1 - 0.99 10.6 5.4 1.3 10.2 1.1 2.7 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch tRNA-synt_1c PF00749.21 EWC43394.1 - 3.4e-110 367.8 0.0 4.5e-110 367.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EWC43394.1 - 1.6e-37 129.0 0.0 2.7e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_2 PF13410.6 EWC43394.1 - 1.9e-05 24.6 0.0 6.8e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EWC43394.1 - 0.00077 19.6 0.0 0.0055 16.9 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Glycogen_syn PF05693.13 EWC43395.1 - 0 1148.1 0.0 0 1147.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EWC43395.1 - 3.9e-05 23.3 0.0 0.011 15.3 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EWC43395.1 - 0.00011 22.1 0.8 0.00023 21.0 0.8 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 EWC43395.1 - 0.00012 22.6 0.0 0.22 12.0 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EWC43395.1 - 0.00019 21.5 1.1 0.00071 19.6 0.9 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EWC43395.1 - 0.0023 18.4 2.2 0.0048 17.4 2.2 1.6 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Oxidored_molyb PF00174.19 EWC43396.1 - 2e-56 190.3 0.0 3.5e-56 189.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EWC43396.1 - 1.1e-14 54.6 0.1 2.6e-14 53.4 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain DUF2111 PF09884.9 EWC43396.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2111) CTP_transf_like PF01467.26 EWC43397.1 - 8.5e-23 81.1 0.0 1.1e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Glyco_transf_15 PF01793.16 EWC43398.1 - 1.3e-114 382.8 6.3 1.6e-114 382.6 6.3 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase GCP_N_terminal PF17681.1 EWC43399.1 - 3.4e-27 95.9 0.0 1.1e-26 94.2 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP5-Mod21 PF14609.6 EWC43399.1 - 1.2e-08 33.8 0.1 2.6e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 GCP_C_terminal PF04130.13 EWC43399.1 - 3.8e-07 29.9 0.0 0.0072 15.8 0.0 3.5 2 1 1 3 3 3 2 Gamma tubulin complex component C-terminal Sigma70_ner PF04546.13 EWC43399.1 - 0.02 14.8 0.6 0.02 14.8 0.6 2.8 2 1 0 2 2 2 0 Sigma-70, non-essential region RRN3 PF05327.11 EWC43399.1 - 3.5 6.1 8.5 6 5.3 0.1 3.0 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 Pkinase PF00069.25 EWC43400.1 - 9.3e-18 64.5 0.0 1.1e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43400.1 - 2.1e-14 53.4 0.0 2.5e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Mucin PF01456.17 EWC43400.1 - 5.9 6.9 17.0 8.2 6.4 17.0 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Pkinase PF00069.25 EWC43401.1 - 1.3e-32 113.3 0.0 2e-32 112.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43401.1 - 5.4e-20 71.8 0.0 8e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC43401.1 - 0.023 14.0 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like SUI1 PF01253.22 EWC43403.1 - 1.2e-18 67.4 0.2 2.4e-18 66.4 0.2 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 Sporozoite_P67 PF05642.11 EWC43403.1 - 0.035 12.2 1.3 0.041 12.0 1.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen HIG_1_N PF04588.13 EWC43404.1 - 1.8e-07 31.3 0.9 5.2e-07 29.8 0.9 1.8 1 0 0 1 1 1 1 Hypoxia induced protein conserved region RNase_H PF00075.24 EWC43405.1 - 3.9e-36 124.4 0.0 7.3e-36 123.5 0.0 1.4 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EWC43405.1 - 3.7e-35 120.0 9.8 4.2e-17 62.2 0.5 3.0 3 0 0 3 3 3 2 Caulimovirus viroplasmin FA_desaturase PF00487.24 EWC43405.1 - 1.1e-22 81.1 19.7 2.3e-22 80.1 19.7 1.4 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EWC43405.1 - 2.9e-06 27.5 0.0 6.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) RVT_3 PF13456.6 EWC43405.1 - 0.026 14.3 0.1 0.14 11.9 0.0 2.4 2 1 0 2 2 2 0 Reverse transcriptase-like 4HBT_2 PF13279.6 EWC43406.1 - 1.2e-07 32.3 0.0 1.9e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily FMN_dh PF01070.18 EWC43407.1 - 1.9e-30 106.1 1.1 2e-30 106.0 1.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EWC43407.1 - 6e-07 28.9 0.1 8.9e-07 28.4 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EWC43407.1 - 6.8e-06 25.3 1.1 3.8e-05 22.9 0.4 1.9 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EWC43407.1 - 0.0019 17.6 0.0 0.0019 17.6 0.0 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EWC43407.1 - 0.0022 17.5 0.1 0.0024 17.3 0.1 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein DHO_dh PF01180.21 EWC43407.1 - 0.12 11.6 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Ribul_P_3_epim PF00834.19 EWC43407.1 - 0.14 11.5 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family vWF_A PF12450.8 EWC43409.1 - 0.067 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor PQ-loop PF04193.14 EWC43411.1 - 1.1e-18 66.7 1.4 2.2e-18 65.8 1.4 1.5 1 0 0 1 1 1 1 PQ loop repeat RHD3 PF05879.12 EWC43412.1 - 5.8e-235 781.9 0.0 8.5e-235 781.4 0.0 1.2 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EWC43412.1 - 1.3e-07 31.1 0.0 2.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain AAA_28 PF13521.6 EWC43412.1 - 3.3e-05 24.2 0.0 8.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Dynamin_N PF00350.23 EWC43412.1 - 5.2e-05 23.4 0.0 0.0001 22.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EWC43412.1 - 0.00012 22.2 0.0 0.00034 20.7 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Closter_coat PF01785.17 EWC43412.1 - 0.016 14.5 0.2 0.034 13.4 0.2 1.5 1 0 0 1 1 1 0 Closterovirus coat protein AAA_16 PF13191.6 EWC43412.1 - 0.18 12.2 1.2 2.2 8.7 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain CENP-F_leu_zip PF10473.9 EWC43413.1 - 0.021 14.9 54.4 0.024 14.6 8.2 4.6 2 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAD PF05557.13 EWC43413.1 - 0.43 8.9 44.8 0.76 8.1 44.8 1.4 1 0 0 1 1 1 0 Mitotic checkpoint protein ATG16 PF08614.11 EWC43413.1 - 0.76 10.0 64.1 2.9 8.1 18.8 3.7 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) DUF2779 PF11074.8 EWC43413.1 - 3 8.3 5.4 2.3 8.7 1.1 2.7 1 1 0 2 2 2 0 Domain of unknown function(DUF2779) ApbA_C PF08546.11 EWC43414.1 - 2.3e-23 82.7 0.0 3.5e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal TMEM171 PF15471.6 EWC43414.1 - 1 8.3 5.4 1.8 7.5 5.4 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 Mito_fiss_reg PF05308.11 EWC43414.1 - 2.4 8.2 9.0 5.7 7.0 9.0 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator AdoMet_MTase PF07757.13 EWC43415.1 - 1.3e-20 73.8 0.0 4.5e-20 72.1 0.0 2.0 2 1 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase RRM_1 PF00076.22 EWC43415.1 - 3.4e-06 26.8 0.0 9.8e-06 25.3 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_6 PF13912.6 EWC43415.1 - 0.086 12.9 0.1 1 9.4 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Lyase_1 PF00206.20 EWC43416.1 - 2e-86 290.2 4.0 1.6e-74 251.1 0.0 2.2 1 1 1 2 2 2 2 Lyase FumaraseC_C PF10415.9 EWC43416.1 - 5.2e-20 71.6 0.0 1.1e-19 70.6 0.0 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus RNase_PH PF01138.21 EWC43417.1 - 1.2e-09 38.8 0.0 2.4e-09 37.8 0.0 1.5 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RRM_1 PF00076.22 EWC43418.1 - 0.074 12.9 0.0 0.19 11.6 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EWC43419.1 - 7.8e-71 238.5 0.0 9.6e-71 238.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43419.1 - 4.6e-37 127.7 0.0 7.1e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC43419.1 - 2.9e-05 23.5 0.0 0.00065 19.1 0.0 2.4 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EWC43419.1 - 0.00092 19.2 0.5 0.02 14.9 0.3 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EWC43419.1 - 0.0066 15.4 0.1 0.0095 14.9 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EWC43419.1 - 0.015 14.1 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EWC43419.1 - 0.017 14.5 0.1 0.027 13.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EWC43419.1 - 0.091 12.3 0.1 0.2 11.2 0.1 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase Zn_clus PF00172.18 EWC43420.1 - 1.2e-07 31.7 6.2 1.8e-07 31.1 6.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fic PF02661.18 EWC43422.1 - 1.3e-05 26.0 0.0 0.0027 18.6 0.0 2.9 1 1 0 1 1 1 1 Fic/DOC family Asp PF00026.23 EWC43423.1 - 2e-28 99.7 0.0 2.7e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease SKG6 PF08693.10 EWC43423.1 - 0.0092 15.4 1.7 0.018 14.5 1.7 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Beta-APP PF03494.13 EWC43423.1 - 1.2 9.1 4.9 2.6 8.0 4.9 1.6 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) RRM_1 PF00076.22 EWC43424.1 - 4.7e-41 138.5 0.9 1.8e-19 69.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EWC43424.1 - 3.2e-22 79.4 0.0 9.9e-22 77.8 0.0 1.9 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein Nup35_RRM_2 PF14605.6 EWC43424.1 - 0.0075 16.2 0.0 12 5.9 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EWC43424.1 - 0.051 13.4 0.0 8.1 6.4 0.0 2.8 3 0 0 3 3 3 0 Occluded RNA-recognition motif ABC_membrane PF00664.23 EWC43425.1 - 6.3e-92 308.1 35.3 4.2e-51 174.2 18.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EWC43425.1 - 1.6e-64 216.5 0.0 1.1e-31 110.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EWC43425.1 - 3.6e-10 39.6 3.7 0.00045 19.7 0.0 4.5 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EWC43425.1 - 7e-09 35.0 0.2 0.0034 16.2 0.0 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 EWC43425.1 - 2.8e-08 34.1 0.7 0.023 15.0 0.0 4.3 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EWC43425.1 - 2.4e-07 31.3 0.3 0.014 15.8 0.0 3.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EWC43425.1 - 5.3e-07 29.3 1.1 0.017 14.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EWC43425.1 - 9.2e-06 25.7 0.7 0.48 10.2 0.0 4.0 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 EWC43425.1 - 1.9e-05 24.0 0.0 0.0084 15.4 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin RsgA_GTPase PF03193.16 EWC43425.1 - 2.1e-05 24.5 0.0 0.18 11.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EWC43425.1 - 0.00016 21.6 0.0 0.012 15.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EWC43425.1 - 0.00016 21.3 0.2 0.77 9.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EWC43425.1 - 0.0006 19.6 0.1 3.3 7.4 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.6 EWC43425.1 - 0.0021 18.3 0.9 0.43 10.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EWC43425.1 - 0.0025 18.0 3.2 1.5 9.1 0.3 4.1 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 EWC43425.1 - 0.0036 17.5 0.0 5.3 7.2 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EWC43425.1 - 0.0042 17.6 0.0 1 9.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EWC43425.1 - 0.0083 15.3 0.0 0.53 9.4 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_23 PF13476.6 EWC43425.1 - 0.021 15.4 0.1 11 6.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EWC43425.1 - 0.03 14.0 0.0 0.83 9.4 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 EWC43425.1 - 0.036 14.0 0.1 0.28 11.1 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_5 PF07728.14 EWC43425.1 - 0.044 13.8 3.3 3.7 7.5 0.0 3.9 5 0 0 5 5 4 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EWC43425.1 - 0.054 13.9 0.9 1.4e+02 2.9 0.0 4.6 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EWC43425.1 - 0.057 13.5 3.2 4.7 7.2 0.2 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EWC43425.1 - 0.082 12.3 0.4 3.4 6.9 0.1 2.7 3 0 0 3 3 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EWC43425.1 - 0.093 12.2 0.0 20 4.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EWC43425.1 - 0.095 13.1 0.1 9.1 6.7 0.0 3.1 2 0 0 2 2 2 0 RNA helicase MoaE PF02391.17 EWC43425.1 - 0.11 12.7 0.4 22 5.3 0.1 2.9 2 0 0 2 2 2 0 MoaE protein MMR_HSR1 PF01926.23 EWC43425.1 - 0.15 12.1 0.2 6.7 6.8 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EWC43425.1 - 0.17 11.6 0.1 18 5.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain CRCB PF02537.15 EWC43425.1 - 0.71 10.2 5.0 0.71 10.2 0.5 3.3 3 0 0 3 3 2 0 CrcB-like protein, Camphor Resistance (CrcB) Zn_clus PF00172.18 EWC43426.1 - 6.4e-10 39.0 13.0 1.3e-09 38.0 13.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EWC43426.1 - 6.7e-07 28.6 0.4 2e-06 27.0 0.1 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain Ribosomal_S7 PF00177.21 EWC43427.1 - 7.4e-36 123.0 1.2 1e-35 122.6 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e PAP2 PF01569.21 EWC43428.1 - 8.5e-25 87.1 5.9 8.5e-25 87.1 5.9 1.8 2 0 0 2 2 2 1 PAP2 superfamily DUF983 PF06170.12 EWC43428.1 - 2.1 8.8 5.5 5.4 7.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF983) SPRY PF00622.28 EWC43430.1 - 3.4e-21 75.6 0.0 6e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain TMEM132D_C PF15706.5 EWC43430.1 - 0.21 11.4 0.0 0.43 10.4 0.0 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term PAC4 PF16093.5 EWC43431.1 - 3.2e-17 62.5 0.1 8.7e-17 61.1 0.0 1.7 2 0 0 2 2 2 1 Proteasome assembly chaperone 4 Cyt-b5 PF00173.28 EWC43432.1 - 1.9e-17 63.1 2.3 9.9e-17 60.9 0.0 2.8 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EWC43432.1 - 8.2e-12 45.6 20.2 8.7e-12 45.5 19.0 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily ATP-synt_I PF03899.15 EWC43432.1 - 0.0066 16.8 0.8 3.6 8.0 0.1 2.2 2 0 0 2 2 2 2 ATP synthase I chain Anth_synt_I_N PF04715.13 EWC43432.1 - 0.15 12.3 0.1 0.27 11.4 0.1 1.3 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region F-box PF00646.33 EWC43433.1 - 2.8e-07 30.3 0.2 0.00015 21.5 0.0 2.8 2 0 0 2 2 2 2 F-box domain F-box-like PF12937.7 EWC43433.1 - 0.076 12.9 0.0 0.076 12.9 0.0 2.2 3 0 0 3 3 3 0 F-box-like F-box-like PF12937.7 EWC43434.1 - 3.4e-09 36.4 0.0 8.1e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 F-box-like SsgA PF04686.12 EWC43435.1 - 0.023 14.7 0.0 0.064 13.3 0.0 1.7 1 0 0 1 1 1 0 Streptomyces sporulation and cell division protein, SsgA Rad51 PF08423.11 EWC43436.1 - 0.083 12.1 0.0 1.1 8.5 0.0 2.5 2 1 0 2 2 2 0 Rad51 Amidase PF01425.21 EWC43437.1 - 1.4e-76 258.3 0.0 7.4e-75 252.6 0.0 2.0 1 1 0 1 1 1 1 Amidase RTA1 PF04479.13 EWC43438.1 - 5.9e-49 166.5 11.0 1.2e-48 165.5 11.0 1.5 1 1 0 1 1 1 1 RTA1 like protein TMEM208_SND2 PF05620.11 EWC43438.1 - 0.25 11.1 9.1 0.17 11.7 2.9 3.1 2 2 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Methyltransf_31 PF13847.6 EWC43439.1 - 2.9e-17 62.9 0.0 3.9e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC43439.1 - 1.2e-06 29.2 0.1 2.2e-06 28.3 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC43439.1 - 4.1e-06 27.4 0.0 7.8e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC43439.1 - 0.0011 18.8 0.0 0.0022 17.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EWC43439.1 - 0.0016 18.0 0.0 0.069 12.7 0.0 2.4 3 0 0 3 3 3 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 EWC43439.1 - 0.0026 17.8 0.0 0.0038 17.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC43439.1 - 0.0041 17.7 0.0 0.011 16.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EWC43439.1 - 0.012 15.1 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 EWC43439.1 - 0.098 11.9 0.0 0.32 10.3 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EWC43440.1 - 4.8e-10 39.4 0.0 6.5e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase GidB PF02527.15 EWC43440.1 - 0.052 12.9 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G PrmA PF06325.13 EWC43440.1 - 0.11 11.9 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NNMT_PNMT_TEMT PF01234.17 EWC43440.1 - 0.18 10.9 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family LMBR1 PF04791.16 EWC43441.1 - 1.9e-106 357.0 3.5 2.2e-106 356.8 3.5 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein CitMHS PF03600.16 EWC43441.1 - 1.5 8.0 7.7 2.5 7.2 7.2 1.8 1 1 0 1 1 1 0 Citrate transporter SLS PF14611.6 EWC43442.1 - 2.7e-31 109.2 0.6 2.7e-31 109.2 0.6 2.3 3 0 0 3 3 3 1 Mitochondrial inner-membrane-bound regulator Secretin_N PF03958.17 EWC43442.1 - 0.0026 18.1 0.0 0.01 16.2 0.0 2.0 1 0 0 1 1 1 1 Bacterial type II/III secretion system short domain DUF4440 PF14534.6 EWC43444.1 - 0.012 16.0 0.0 0.028 14.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Xpo1 PF08389.12 EWC43444.1 - 0.1 12.7 0.0 0.7 10.0 0.0 2.2 2 0 0 2 2 2 0 Exportin 1-like protein MAGE PF01454.19 EWC43445.1 - 1.8e-54 184.7 0.6 2.6e-54 184.2 0.0 1.5 2 0 0 2 2 2 1 MAGE family RRN3 PF05327.11 EWC43445.1 - 4.6 5.7 6.0 6.8 5.1 6.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PI3K_1B_p101 PF10486.9 EWC43445.1 - 6.2 4.5 5.4 3.5 5.3 3.4 1.5 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit HEAT PF02985.22 EWC43446.1 - 4.7e-39 129.1 19.0 0.0065 16.6 0.0 13.7 15 0 0 15 15 15 10 HEAT repeat HEAT_2 PF13646.6 EWC43446.1 - 1.5e-32 111.8 13.1 3.3e-09 37.0 0.0 8.5 3 1 5 8 8 8 7 HEAT repeats HEAT_EZ PF13513.6 EWC43446.1 - 1.6e-11 44.5 12.6 0.012 16.1 0.5 9.5 8 2 3 11 11 11 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EWC43446.1 - 3e-11 43.8 2.8 0.1 13.2 0.0 7.5 5 2 4 9 9 9 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EWC43446.1 - 1.3e-10 41.5 8.4 0.00024 21.2 0.2 5.9 4 1 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EWC43446.1 - 3.1e-07 29.3 10.4 0.025 13.1 0.4 5.6 3 1 2 6 6 6 3 Adaptin N terminal region RTP1_C1 PF10363.9 EWC43446.1 - 1e-05 25.7 5.1 0.072 13.3 0.1 4.7 4 1 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EWC43446.1 - 0.00024 20.8 0.5 6.9 6.2 0.1 4.5 4 1 1 5 5 5 2 CLASP N terminal Arm PF00514.23 EWC43446.1 - 0.031 14.3 16.2 0.15 12.2 0.0 6.8 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat DNA_alkylation PF08713.11 EWC43446.1 - 0.071 12.8 0.1 1.1 8.9 0.0 2.7 2 1 0 3 3 3 0 DNA alkylation repair enzyme Ecm29 PF13001.7 EWC43446.1 - 0.27 9.9 5.7 0.35 9.5 0.1 2.8 3 0 0 3 3 3 0 Proteasome stabiliser IFRD PF05004.13 EWC43446.1 - 0.32 10.1 2.4 0.52 9.4 0.1 2.5 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) HEAT_PBS PF03130.16 EWC43446.1 - 0.39 11.5 3.3 2.4 9.1 0.1 4.1 5 0 0 5 5 3 0 PBS lyase HEAT-like repeat Proteasom_PSMB PF10508.9 EWC43446.1 - 0.83 8.1 5.4 0.77 8.2 0.1 2.4 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit API5 PF05918.11 EWC43446.1 - 3.3 6.4 9.7 0.12 11.1 0.4 3.1 5 0 0 5 5 5 0 Apoptosis inhibitory protein 5 (API5) tRNA_synthFbeta PF17759.1 EWC43447.1 - 4.4e-48 163.6 0.0 6.7e-48 163.0 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EWC43447.1 - 8.8e-34 115.6 0.3 6.2e-31 106.5 0.0 2.5 2 0 0 2 2 2 2 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EWC43447.1 - 4.6e-23 81.8 0.0 7.4e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EWC43447.1 - 1.7e-18 66.6 0.1 2.6e-16 59.7 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain 2OG-FeII_Oxy_2 PF13532.6 EWC43448.1 - 7.8e-10 39.3 0.0 1.4e-08 35.2 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UAA PF08449.11 EWC43449.1 - 4.6e-48 164.0 4.8 5.4e-48 163.7 4.8 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EWC43449.1 - 7.9e-09 35.8 21.8 2e-07 31.2 2.7 3.2 3 0 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EWC43449.1 - 5e-06 25.9 1.8 0.00045 19.5 0.1 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter TPT PF03151.16 EWC43449.1 - 0.18 11.1 4.3 0.29 10.4 0.5 2.3 2 0 0 2 2 2 0 Triose-phosphate Transporter family SLC35F PF06027.12 EWC43449.1 - 0.97 8.9 9.5 0.25 10.8 5.6 1.9 2 1 0 2 2 2 0 Solute carrier family 35 Abhydrolase_6 PF12697.7 EWC43450.1 - 8.8e-17 62.4 4.7 1.4e-16 61.8 2.2 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EWC43450.1 - 8.1e-11 42.0 0.0 1.3e-10 41.4 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC43450.1 - 0.0009 18.6 0.0 0.0017 17.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 EHN PF06441.12 EWC43450.1 - 0.024 15.0 0.0 0.11 12.9 0.0 2.0 2 0 0 2 2 2 0 Epoxide hydrolase N terminus Herpes_UL17 PF04559.12 EWC43450.1 - 0.059 12.2 0.0 0.085 11.7 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein MFS_1 PF07690.16 EWC43451.1 - 1.8e-44 152.1 30.2 3.9e-35 121.4 22.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EWC43451.1 - 6.3e-05 21.6 14.9 0.0014 17.2 4.6 2.8 3 0 0 3 3 3 2 Transmembrane secretion effector MFS_1_like PF12832.7 EWC43451.1 - 6.4e-05 22.0 15.9 0.00052 19.0 5.2 4.0 2 2 2 4 4 4 1 MFS_1 like family Sugar_tr PF00083.24 EWC43451.1 - 0.0091 14.9 1.5 0.0091 14.9 1.5 3.3 2 2 1 3 3 3 2 Sugar (and other) transporter ATG22 PF11700.8 EWC43451.1 - 0.059 12.0 7.1 2.1 6.9 0.2 3.3 2 1 0 3 3 3 0 Vacuole effluxer Atg22 like CLN3 PF02487.17 EWC43451.1 - 0.082 11.9 6.9 0.16 11.0 0.6 2.3 2 0 0 2 2 2 0 CLN3 protein OATP PF03137.20 EWC43451.1 - 0.13 10.6 9.4 0.014 13.7 1.9 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Deltameth_res PF16020.5 EWC43451.1 - 0.34 10.8 2.3 1.5 8.7 0.0 3.2 3 0 0 3 3 3 0 Deltamethrin resistance DUF4131 PF13567.6 EWC43451.1 - 0.47 10.1 9.9 0.21 11.2 0.9 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) V-ATPase_G PF03179.15 EWC43452.1 - 2.2e-30 105.3 17.4 2.6e-30 105.1 17.4 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit RGS-like PF09128.11 EWC43452.1 - 0.025 14.3 3.6 0.026 14.2 3.6 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain YusW PF14039.6 EWC43452.1 - 0.033 14.7 3.1 0.033 14.7 3.1 1.4 1 1 0 1 1 1 0 YusW-like protein CTNNB1_binding PF08347.11 EWC43452.1 - 0.1 12.8 0.5 0.12 12.5 0.5 1.1 1 0 0 1 1 1 0 N-terminal CTNNB1 binding OmpH PF03938.14 EWC43452.1 - 0.16 12.3 12.1 0.21 11.9 12.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ATP-synt_B PF00430.18 EWC43452.1 - 0.53 10.4 23.0 6 7.0 22.4 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) CemA PF03040.14 EWC43452.1 - 1 9.2 4.3 1.4 8.8 4.3 1.2 1 0 0 1 1 1 0 CemA family DUF4230 PF14014.6 EWC43452.1 - 4 7.7 9.4 14 5.9 9.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4230) HAUS6_N PF14661.6 EWC43452.1 - 4.4 6.8 8.7 4.9 6.7 8.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus PET117 PF15786.5 EWC43453.1 - 9e-24 83.5 1.3 1e-23 83.4 1.3 1.0 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial DUF4956 PF16316.5 EWC43453.1 - 0.059 13.0 0.2 0.064 12.9 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) Methyltransf_16 PF10294.9 EWC43455.1 - 1.5e-19 70.4 0.0 2.3e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EWC43455.1 - 6.5e-05 22.5 0.1 8.6e-05 22.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ribosomal_S24e PF01282.19 EWC43456.1 - 1.7e-33 114.4 0.1 3.2e-33 113.5 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e DnaJ PF00226.31 EWC43457.1 - 5.3e-15 55.3 0.1 1.1e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Yip1 PF04893.17 EWC43457.1 - 4.7 6.9 8.5 0.24 11.1 0.4 2.2 2 0 0 2 2 2 0 Yip1 domain Nsp1_C PF05064.13 EWC43458.1 - 1.2e-32 112.1 2.4 1.7e-32 111.7 0.3 2.0 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EWC43458.1 - 0.0032 18.3 72.7 0.028 15.3 5.1 4.5 2 1 0 2 2 2 1 Nucleoporin FG repeat region PRCC PF10253.9 EWC43458.1 - 0.013 16.4 2.4 0.013 16.4 2.4 2.1 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting BORCS8 PF10167.9 EWC43458.1 - 0.018 15.0 0.8 0.035 14.0 0.2 1.7 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 BRE1 PF08647.11 EWC43458.1 - 0.092 12.8 5.4 0.81 9.8 0.7 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase LMBR1 PF04791.16 EWC43458.1 - 0.56 9.1 3.2 1.1 8.1 0.5 1.9 1 1 1 2 2 2 0 LMBR1-like membrane protein DUF1664 PF07889.12 EWC43458.1 - 7.2 6.7 5.7 13 5.8 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) SBDS PF01172.18 EWC43459.1 - 3.1e-26 91.3 0.1 3.6e-26 91.1 0.1 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein PhageP22-tail PF09251.10 EWC43459.1 - 0.015 13.7 0.0 0.017 13.5 0.0 1.0 1 0 0 1 1 1 0 Salmonella phage P22 tail-spike Tropomyosin_1 PF12718.7 EWC43461.1 - 0.004 17.3 21.8 0.004 17.3 21.8 1.9 2 0 0 2 2 2 1 Tropomyosin like ADIP PF11559.8 EWC43461.1 - 0.061 13.4 24.4 0.32 11.1 6.4 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Tropomyosin PF00261.20 EWC43461.1 - 0.081 12.3 27.6 0.045 13.1 6.3 2.7 1 1 2 3 3 3 0 Tropomyosin Jnk-SapK_ap_N PF09744.9 EWC43461.1 - 0.28 11.4 30.4 0.44 10.8 13.9 2.6 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 CHD5 PF04420.14 EWC43461.1 - 1.5 8.7 12.5 0.11 12.4 4.2 2.6 2 1 1 3 3 3 0 CHD5-like protein Shugoshin_N PF07558.11 EWC43461.1 - 2 8.4 7.6 0.79 9.6 0.2 3.0 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region LPP PF04728.13 EWC43461.1 - 7.3 7.1 9.4 12 6.4 1.6 3.8 1 1 2 3 3 3 0 Lipoprotein leucine-zipper HAP1_N PF04849.13 EWC43461.1 - 7.4 5.7 33.7 60 2.7 33.4 2.2 1 1 0 1 1 1 0 HAP1 N-terminal conserved region ubiquitin PF00240.23 EWC43462.1 - 6e-21 74.0 0.0 9.1e-21 73.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EWC43462.1 - 2.5e-08 33.6 0.0 4.1e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 EWC43462.1 - 8.2e-06 25.6 0.0 8.2e-06 25.6 0.0 2.8 3 0 0 3 3 3 1 UBA/TS-N domain DUF2407 PF10302.9 EWC43462.1 - 0.00012 22.6 0.0 0.00022 21.8 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EWC43462.1 - 0.00066 19.8 0.0 0.0016 18.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EWC43462.1 - 0.0028 18.1 0.0 0.0077 16.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain HOIP-UBA PF16678.5 EWC43462.1 - 0.058 13.4 0.0 0.095 12.7 0.0 1.2 1 0 0 1 1 1 0 HOIP UBA domain pair TBK1_ULD PF18396.1 EWC43462.1 - 0.21 11.5 0.0 0.41 10.6 0.0 1.4 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain NAD_binding_6 PF08030.12 EWC43464.1 - 2.4e-23 83.0 0.0 4e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EWC43464.1 - 4.7e-23 81.3 0.0 1.1e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EWC43464.1 - 3e-19 69.3 9.5 3e-19 69.3 9.5 2.3 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 EWC43464.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EWC43464.1 - 0.12 13.1 0.0 1.3 9.7 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain SNF2_N PF00176.23 EWC43465.1 - 1e-60 205.3 0.1 1.7e-60 204.6 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC43465.1 - 6.6e-17 61.9 0.1 3.3e-16 59.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 EWC43465.1 - 4.6e-07 29.8 1.6 9.8e-07 28.7 1.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger ResIII PF04851.15 EWC43465.1 - 5.1e-07 29.8 0.3 2.8e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EWC43465.1 - 6.9e-07 29.0 5.9 1.3e-06 28.1 5.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC43465.1 - 3.9e-06 26.6 4.7 8e-06 25.6 4.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC43465.1 - 4.8e-06 26.8 3.8 9.7e-06 25.8 3.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EWC43465.1 - 0.00025 20.9 4.5 0.00046 20.1 4.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EWC43465.1 - 0.0024 17.7 3.2 0.0024 17.7 3.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EWC43465.1 - 0.037 13.9 8.1 0.2 11.6 8.1 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EWC43465.1 - 0.061 13.1 4.1 0.14 11.9 4.1 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EWC43465.1 - 0.1 12.8 5.4 0.24 11.6 5.4 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING SH3_1 PF00018.28 EWC43466.1 - 7.1e-12 44.7 0.0 1.4e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC43466.1 - 1.1e-10 41.2 0.1 1.9e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.17 EWC43466.1 - 1.9e-10 40.7 0.2 3.3e-10 39.9 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 EWC43466.1 - 5.4e-09 36.5 0.0 2.3e-08 34.5 0.0 2.0 1 1 0 1 1 1 1 PH domain SH3_2 PF07653.17 EWC43466.1 - 0.00082 19.0 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EWC43466.1 - 0.023 15.1 0.0 0.061 13.8 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PH_8 PF15409.6 EWC43466.1 - 0.039 14.2 0.2 0.19 12.0 0.2 2.2 1 1 1 2 2 2 0 Pleckstrin homology domain SAM_1 PF00536.30 EWC43466.1 - 0.045 14.2 0.1 0.077 13.4 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Avl9 PF09794.9 EWC43467.1 - 1.8e-131 438.4 0.0 2.4e-131 437.9 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 EWC43467.1 - 6.1e-06 26.2 0.0 0.0012 18.8 0.0 2.3 2 0 0 2 2 2 1 Stabilization of polarity axis Na_trans_assoc PF06512.13 EWC43467.1 - 0.4 10.9 12.4 0.15 12.3 7.4 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated DUF2347 PF09804.9 EWC43467.1 - 0.71 9.4 19.7 0.054 13.1 2.2 4.1 4 1 0 4 4 4 0 Uncharacterized conserved protein (DUF2347) PPP4R2 PF09184.11 EWC43467.1 - 0.76 9.3 13.3 1.5 8.4 13.3 1.4 1 0 0 1 1 1 0 PPP4R2 CKAP2_C PF15297.6 EWC43467.1 - 1.4 7.9 18.6 0.044 12.9 1.0 2.2 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus RR_TM4-6 PF06459.12 EWC43467.1 - 3.3 7.5 18.7 0.42 10.4 10.1 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RPN2_C PF18004.1 EWC43467.1 - 3.5 7.5 24.6 1.3 8.9 14.2 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain AIM3 PF17096.5 EWC43467.1 - 3.6 8.6 16.7 0.6 11.1 5.3 2.9 3 0 0 3 3 3 0 Altered inheritance of mitochondria protein 3 DUF719 PF05334.13 EWC43467.1 - 7.9 6.6 13.7 3.9 7.6 4.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Pkinase PF00069.25 EWC43468.1 - 2.4e-68 230.3 0.0 3e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43468.1 - 6.7e-32 110.8 0.0 8.5e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EWC43468.1 - 8.1e-06 25.0 0.1 1.1e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EWC43468.1 - 0.00021 20.7 0.1 0.00069 19.0 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EWC43468.1 - 0.00065 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EWC43468.1 - 0.00097 18.5 0.0 0.16 11.3 0.0 2.2 1 1 1 2 2 2 2 Kinase-like FTA2 PF13095.6 EWC43468.1 - 0.016 14.9 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EWC43468.1 - 0.031 13.9 0.0 0.072 12.7 0.0 1.6 2 0 0 2 2 2 0 RIO1 family CAP PF00188.26 EWC43469.1 - 5.3e-09 37.0 0.1 5.3e-09 37.0 0.1 2.0 2 0 0 2 2 2 1 Cysteine-rich secretory protein family RXLR PF16810.5 EWC43469.1 - 0.017 15.6 0.0 0.037 14.5 0.0 1.6 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity SKN1 PF03935.15 EWC43470.1 - 1.2e-232 772.7 0.4 1.5e-232 772.5 0.4 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) MARVEL PF01284.23 EWC43471.1 - 0.0011 19.1 6.3 0.0015 18.5 6.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain Herpes_LMP1 PF05297.11 EWC43471.1 - 0.53 9.4 2.2 2.3 7.3 0.2 2.1 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Cullin PF00888.22 EWC43472.1 - 1.5e-198 661.4 15.1 1.8e-198 661.1 15.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EWC43472.1 - 2.6e-25 88.2 2.2 9e-25 86.5 2.2 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain AnfG_VnfG PF03139.15 EWC43472.1 - 0.073 13.2 1.8 0.66 10.1 0.6 3.1 3 0 0 3 3 3 0 Vanadium/alternative nitrogenase delta subunit Iso_dh PF00180.20 EWC43473.1 - 4.6e-95 318.7 0.0 5.5e-95 318.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PhzC-PhzF PF02567.16 EWC43474.1 - 5.9e-37 127.7 0.0 1.4e-36 126.4 0.0 1.6 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.11 EWC43474.1 - 0.0075 15.4 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Proline racemase DUF2046 PF09755.9 EWC43475.1 - 0.14 11.4 0.3 0.31 10.2 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) PH PF00169.29 EWC43476.1 - 0.2 12.1 0.0 0.45 11.1 0.0 1.6 1 1 0 1 1 1 0 PH domain Ank_2 PF12796.7 EWC43477.1 - 7.6e-07 29.6 0.0 0.047 14.3 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EWC43477.1 - 2.7e-06 27.3 0.0 2 9.2 0.0 5.4 5 0 0 5 5 5 2 Ankyrin repeat NACHT PF05729.12 EWC43477.1 - 3.6e-06 27.0 0.1 2.5e-05 24.2 0.0 2.4 3 0 0 3 3 3 1 NACHT domain Ank_5 PF13857.6 EWC43477.1 - 1.8e-05 24.9 0.0 0.93 9.9 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) AAA_22 PF13401.6 EWC43477.1 - 0.00072 19.8 0.0 0.0024 18.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain Ank PF00023.30 EWC43477.1 - 0.063 13.8 0.0 19 5.9 0.0 4.4 5 0 0 5 5 5 0 Ankyrin repeat Sec5 PF15469.6 EWC43479.1 - 2.6e-51 174.1 0.1 5e-51 173.2 0.1 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 EWC43479.1 - 1.7e-05 24.8 0.1 5.5e-05 23.2 0.1 1.9 1 0 0 1 1 1 1 Vps51/Vps67 HAD_2 PF13419.6 EWC43480.1 - 6.2e-07 29.7 0.0 9.1e-07 29.1 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EWC43480.1 - 3e-06 27.7 0.0 1.1e-05 25.8 0.0 1.7 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EWC43480.1 - 6.4e-05 22.9 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Acid_PPase PF12689.7 EWC43480.1 - 0.024 14.5 0.0 0.66 9.8 0.0 2.1 2 0 0 2 2 2 0 Acid Phosphatase Xpo1 PF08389.12 EWC43484.1 - 1.9e-31 109.2 0.2 1.6e-30 106.1 0.0 2.7 3 0 0 3 3 3 1 Exportin 1-like protein ALMS_repeat PF18727.1 EWC43484.1 - 0.026 14.4 0.0 0.11 12.4 0.0 2.1 1 0 0 1 1 1 0 Alstrom syndrome repeat Exo_endo_phos PF03372.23 EWC43485.1 - 3e-19 69.5 0.7 1.9e-18 66.8 0.7 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 EWC43485.1 - 2.1e-07 31.1 10.4 0.00012 22.4 0.3 3.5 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EWC43485.1 - 7.5e-07 28.8 7.3 0.00032 20.4 1.2 2.4 1 1 1 2 2 2 2 Leucine rich repeat DUF366 PF04017.12 EWC43485.1 - 0.19 11.2 0.0 2.3 7.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF366) LRR_1 PF00560.33 EWC43485.1 - 0.22 12.2 3.4 1.4e+02 3.6 0.0 4.9 3 1 0 3 3 3 0 Leucine Rich Repeat Methyltransf_25 PF13649.6 EWC43486.1 - 5.2e-12 46.3 0.0 3.2e-11 43.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC43486.1 - 2.7e-08 34.3 0.0 7.6e-08 32.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC43486.1 - 4.6e-08 33.1 0.0 1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC43486.1 - 2.3e-05 24.3 0.0 0.0022 17.8 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC43486.1 - 5.2e-05 23.9 0.0 0.00053 20.7 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC43486.1 - 0.00041 19.8 0.0 0.0009 18.6 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EWC43486.1 - 0.083 12.5 0.0 0.56 9.8 0.0 2.1 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 EWC43486.1 - 0.11 12.0 0.0 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase Biotin_lipoyl PF00364.22 EWC43487.1 - 2e-18 66.0 0.2 6.1e-18 64.4 0.1 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 EWC43487.1 - 2.3e-08 34.2 1.4 4.2e-08 33.4 0.1 2.2 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EWC43487.1 - 0.00028 20.6 0.1 0.015 15.1 0.0 2.5 2 0 0 2 2 2 1 Biotin-lipoyl like DNA_primase_lrg PF04104.14 EWC43488.1 - 6.7e-83 278.1 0.0 1.5e-82 277.0 0.0 1.5 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit DUF2457 PF10446.9 EWC43489.1 - 5.1e-68 230.3 54.9 5.1e-68 230.3 54.9 3.4 3 1 0 3 3 3 2 Protein of unknown function (DUF2457) TFIIA PF03153.13 EWC43489.1 - 1.6 8.7 13.1 0.24 11.3 8.8 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Extensin_2 PF04554.13 EWC43489.1 - 4.9 7.3 19.9 9.1 6.4 6.2 2.9 2 0 0 2 2 2 0 Extensin-like region K_channel_TID PF07941.11 EWC43490.1 - 0.0027 18.1 2.4 0.01 16.3 2.4 2.0 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain Peptidase_M18 PF02127.15 EWC43491.1 - 4.6e-169 562.8 0.0 6.1e-168 559.1 0.0 1.9 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EWC43491.1 - 0.00086 18.4 0.1 0.0026 16.8 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase WD40 PF00400.32 EWC43492.1 - 3.4e-25 87.8 8.6 1.4e-05 25.7 0.0 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC43492.1 - 4.5e-13 49.3 4.0 0.00083 19.6 0.1 4.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EWC43492.1 - 4.3e-09 36.5 0.3 0.0044 16.9 0.1 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EWC43492.1 - 0.0037 16.3 0.0 0.0089 15.0 0.0 1.6 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein HLH PF00010.26 EWC43493.1 - 8.2e-14 51.3 0.1 1.6e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain NTF2 PF02136.20 EWC43495.1 - 2e-27 96.1 0.2 2.9e-27 95.6 0.2 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EWC43495.1 - 3.6e-05 23.5 0.0 6.7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_6 PF12697.7 EWC43496.1 - 0.031 14.9 0.0 0.035 14.7 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family DND1_DSRM PF14709.7 EWC43499.1 - 0.074 13.3 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 TatD_DNase PF01026.21 EWC43500.1 - 5.3e-26 91.5 0.0 7.8e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase OAD_gamma PF04277.13 EWC43501.1 - 0.016 15.8 0.0 0.025 15.2 0.0 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF202 PF02656.15 EWC43501.1 - 0.021 15.3 0.1 0.026 15.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) PAP_PilO PF06864.12 EWC43501.1 - 0.051 12.4 0.0 0.053 12.4 0.0 1.0 1 0 0 1 1 1 0 Pilin accessory protein (PilO) S1FA PF04689.13 EWC43501.1 - 0.11 12.6 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 DNA binding protein S1FA HP1451_C PF18472.1 EWC43503.1 - 0.06 13.3 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 HP1451 C-terminal domain Cellulase PF00150.18 EWC43504.1 - 7.5e-37 127.3 0.6 1.1e-36 126.7 0.6 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) TetR_C_19 PF17924.1 EWC43504.1 - 0.4 11.3 1.3 7.3 7.2 0.2 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain SNF2_N PF00176.23 EWC43505.1 - 6.2e-61 206.0 0.1 1.6e-60 204.7 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC43505.1 - 3.3e-22 78.9 0.0 1.1e-21 77.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC43505.1 - 2.5e-07 30.9 0.0 9.5e-07 29.0 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EWC43505.1 - 0.00014 21.2 0.9 0.00023 20.4 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 EWC43505.1 - 0.00094 18.4 0.2 1.2 8.2 0.0 3.3 2 2 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 Carn_acyltransf PF00755.20 EWC43506.1 - 2.8e-198 660.3 0.0 3.2e-198 660.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Eaf7 PF07904.13 EWC43507.1 - 1.4e-22 80.1 0.0 1.4e-22 80.1 0.0 3.8 3 2 0 3 3 3 1 Chromatin modification-related protein EAF7 GCP_C_terminal PF04130.13 EWC43508.1 - 4.8e-65 220.0 0.0 8.9e-65 219.2 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EWC43508.1 - 1.6e-48 166.0 0.2 1.6e-48 166.0 0.2 1.5 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal 5-FTHF_cyc-lig PF01812.20 EWC43508.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family GFO_IDH_MocA PF01408.22 EWC43511.1 - 1.9e-23 83.5 0.0 3.1e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EWC43511.1 - 3.5e-05 23.8 0.0 6.8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EWC43511.1 - 0.0014 19.3 0.1 0.0024 18.5 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 EWC43511.1 - 0.0058 17.1 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain BrnT_toxin PF04365.13 EWC43511.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system MCM PF00493.23 EWC43512.1 - 2.1e-96 321.4 0.1 4.3e-96 320.4 0.1 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EWC43512.1 - 2.5e-31 108.1 0.0 4.4e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EWC43512.1 - 5.2e-23 81.3 2.3 1.1e-22 80.2 2.3 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EWC43512.1 - 3.4e-14 53.3 0.0 1.1e-13 51.6 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EWC43512.1 - 1.6e-07 30.9 0.0 1.9e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EWC43512.1 - 0.0039 17.1 0.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EWC43512.1 - 0.011 15.5 4.2 0.027 14.3 4.2 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EWC43512.1 - 0.019 14.7 0.0 0.056 13.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF3246 PF11596.8 EWC43512.1 - 0.023 14.2 2.6 0.053 13.0 2.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) SARAF PF06682.12 EWC43512.1 - 0.36 10.4 3.0 0.65 9.6 3.0 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Tmemb_cc2 PF10267.9 EWC43512.1 - 2.3 7.3 9.0 0.08 12.1 0.6 2.2 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein p450 PF00067.22 EWC43513.1 - 6.8e-52 176.8 0.0 9.5e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Histone_H2A_C PF16211.5 EWC43514.1 - 1.4e-21 75.9 2.8 2.8e-21 74.9 2.8 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EWC43514.1 - 8e-18 65.1 0.0 1e-17 64.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EWC43514.1 - 1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EWC43515.1 - 2.5e-22 79.6 1.6 3.1e-22 79.3 1.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EWC43515.1 - 0.00011 22.4 0.0 0.00011 22.4 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EWC43515.1 - 0.00027 21.4 0.0 0.00046 20.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 EWC43515.1 - 0.029 14.0 0.1 0.065 12.9 0.1 1.5 1 1 0 1 1 1 0 Replication protein C N-terminal domain DUF1018 PF06252.12 EWC43515.1 - 0.047 14.7 0.3 0.069 14.1 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) Cytochrome-c551 PF10643.9 EWC43515.1 - 0.058 13.0 0.2 0.081 12.5 0.2 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 NUDIX PF00293.28 EWC43516.1 - 3.7e-08 33.5 0.0 1.3e-07 31.7 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain eIF3_N PF09440.10 EWC43517.1 - 2e-47 160.9 1.3 8.6e-47 158.9 1.2 2.1 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EWC43517.1 - 4.5e-14 52.8 0.2 1.4e-13 51.2 0.1 2.0 2 0 0 2 2 2 1 PCI domain Oxysterol_BP PF01237.18 EWC43518.1 - 1.6e-35 122.7 0.2 3.4e-18 65.6 0.5 3.0 1 1 1 2 2 2 2 Oxysterol-binding protein COX4 PF02936.14 EWC43519.1 - 2.9e-48 163.4 0.0 3.5e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF3106 PF11304.8 EWC43519.1 - 0.038 14.4 1.1 0.038 14.4 1.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) Gp_dh_C PF02800.20 EWC43520.1 - 1.2e-70 236.2 0.0 1.6e-70 235.8 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EWC43520.1 - 1.1e-37 128.4 0.0 2e-37 127.6 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EWC43520.1 - 0.0051 16.9 0.1 0.092 12.9 0.0 2.5 3 0 0 3 3 3 1 Dihydrodipicolinate reductase, N-terminus SAE2 PF08573.10 EWC43521.1 - 7.9e-18 65.6 4.7 7.9e-18 65.6 4.7 2.6 3 1 0 3 3 3 1 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF4200 PF13863.6 EWC43521.1 - 0.031 14.7 0.9 0.031 14.7 0.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Arm PF00514.23 EWC43522.1 - 9.1e-06 25.5 9.2 0.13 12.4 0.1 7.4 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EWC43522.1 - 0.017 15.3 4.8 6 7.4 0.0 5.7 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 EWC43522.1 - 0.037 14.5 6.7 0.97 10.0 0.1 4.9 5 0 0 5 5 5 0 HEAT-like repeat BAF250_C PF12031.8 EWC43522.1 - 0.05 12.9 0.0 0.16 11.3 0.0 1.9 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa IFRD PF05004.13 EWC43522.1 - 0.085 11.9 0.4 1.3 8.0 0.1 2.9 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) Cyclin PF08613.11 EWC43523.1 - 2.1e-29 103.0 0.4 2.1e-29 103.0 0.4 2.0 2 1 0 2 2 2 1 Cyclin Mito_carr PF00153.27 EWC43524.1 - 5.1e-16 58.4 0.1 8.3e-10 38.5 0.0 2.6 2 0 0 2 2 2 2 Mitochondrial carrier protein ERG4_ERG24 PF01222.17 EWC43525.1 - 6.3e-137 456.9 21.1 8.3e-137 456.5 21.1 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Fructosamin_kin PF03881.14 EWC43525.1 - 1.3e-62 211.7 0.0 1.7e-62 211.2 0.0 1.2 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EWC43525.1 - 4.3e-05 23.6 0.0 8.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Velvet PF11754.8 EWC43526.1 - 6.6e-51 173.7 0.0 5.5e-34 118.2 0.0 4.2 2 2 1 3 3 3 2 Velvet factor U1snRNP70_N PF12220.8 EWC43527.1 - 1.6 9.4 12.3 1.4 9.6 0.1 3.5 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal SPT16 PF08644.11 EWC43528.1 - 2.5e-56 190.1 0.6 2.5e-56 190.1 0.6 2.0 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EWC43528.1 - 7.5e-48 162.4 0.1 2e-47 161.0 0.1 1.8 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EWC43528.1 - 7.2e-25 87.9 0.0 1.3e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EWC43528.1 - 1.1e-14 54.6 0.8 2.5e-14 53.4 0.1 2.0 2 0 0 2 2 2 1 Histone chaperone Rttp106-like RTA1 PF04479.13 EWC43529.1 - 7.1e-42 143.4 4.5 1e-41 142.8 4.5 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF308 PF03729.13 EWC43529.1 - 0.016 15.5 1.0 0.24 11.8 0.5 2.9 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) MSA-2c PF12238.8 EWC43529.1 - 0.18 11.8 0.1 0.26 11.3 0.1 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c 7TMR-DISM_7TM PF07695.11 EWC43529.1 - 0.68 9.8 9.9 0.6 10.0 3.2 2.3 2 0 0 2 2 2 0 7TM diverse intracellular signalling 6PF2K PF01591.18 EWC43530.1 - 2.2e-64 216.8 0.0 1.4e-45 155.3 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EWC43530.1 - 7.5e-30 104.1 0.0 1.6e-22 80.1 0.0 2.5 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EWC43530.1 - 0.0038 17.4 0.0 0.085 13.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 EWC43530.1 - 0.021 14.3 0.0 0.05 13.1 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Thoc2 PF11732.8 EWC43530.1 - 0.05 13.7 0.0 0.32 11.1 0.0 2.1 2 0 0 2 2 2 0 Transcription- and export-related complex subunit dCMP_cyt_deam_1 PF00383.23 EWC43531.1 - 5e-11 42.4 0.1 1.1e-10 41.3 0.1 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EWC43531.1 - 5.5e-05 22.9 0.1 0.00017 21.4 0.1 1.8 1 0 0 1 1 1 1 MafB19-like deaminase MFS_1 PF07690.16 EWC43532.1 - 7e-22 77.8 58.0 3.1e-18 65.8 34.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CFTR_R PF14396.6 EWC43532.1 - 0.016 14.8 0.4 0.016 14.8 0.4 1.7 1 1 1 2 2 2 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain zf-RING_2 PF13639.6 EWC43534.1 - 2.4e-10 40.6 0.5 5.1e-10 39.5 0.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EWC43534.1 - 4.4e-10 39.1 1.7 8e-10 38.3 1.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EWC43534.1 - 7.9e-08 32.2 0.7 1.6e-07 31.2 0.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EWC43534.1 - 1.7e-06 27.8 0.2 3.9e-06 26.6 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC43534.1 - 1.7e-05 24.6 0.3 1.7e-05 24.6 0.3 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC43534.1 - 0.00013 21.9 0.2 0.00013 21.9 0.2 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EWC43534.1 - 0.0012 19.1 0.4 0.0047 17.2 0.4 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EWC43534.1 - 0.025 14.7 0.4 0.065 13.4 0.4 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EWC43534.1 - 0.084 12.5 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EWC43534.1 - 0.96 9.4 4.1 34 4.4 4.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 PPP4R2 PF09184.11 EWC43535.1 - 6.9e-10 39.0 0.2 1e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 PPP4R2 Med13_C PF06333.12 EWC43535.1 - 0.032 13.5 7.3 0.043 13.1 7.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain SGL PF08450.12 EWC43536.1 - 0.00078 19.1 0.0 0.042 13.4 0.0 2.5 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EWC43536.1 - 0.0041 17.1 0.0 3 8.0 0.0 3.6 4 0 0 4 4 4 2 NHL repeat Ntox33 PF15533.6 EWC43536.1 - 0.055 13.9 0.0 5.3 7.6 0.0 2.6 2 0 0 2 2 2 0 Bacterial toxin 33 zinc_ribbon_15 PF17032.5 EWC43537.1 - 4.7e-08 33.7 0.3 5.9e-08 33.4 0.3 1.1 1 0 0 1 1 1 1 zinc-ribbon family PSCyt2 PF07583.11 EWC43537.1 - 0.018 15.0 0.2 0.025 14.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1549) Elf1 PF05129.13 EWC43537.1 - 0.11 12.5 3.1 1.2 9.2 3.1 2.0 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like DUF1924 PF09086.11 EWC43537.1 - 0.15 12.4 2.1 0.82 10.1 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1924) 2OG-FeII_Oxy PF03171.20 EWC43539.1 - 0.001 19.5 0.0 0.011 16.2 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Catalase PF00199.19 EWC43540.1 - 7.8e-170 565.1 0.0 1.2e-169 564.5 0.0 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EWC43540.1 - 2.2e-15 56.6 0.0 4.5e-15 55.6 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EWC43540.1 - 3.4e-11 43.0 0.1 1.6e-10 40.8 0.1 2.2 2 1 0 2 2 2 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 EWC43540.1 - 6.8e-09 35.7 0.0 1.2e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family FRG1 PF06229.12 EWC43541.1 - 1.6e-37 129.1 0.0 1.6e-37 129.1 0.0 1.9 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 EWC43541.1 - 0.0028 17.9 0.0 0.0072 16.5 0.0 1.7 1 0 0 1 1 1 1 Fascin domain DUF496 PF04363.12 EWC43541.1 - 0.059 13.4 0.4 0.059 13.4 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF496) YojJ PF10372.9 EWC43541.1 - 0.14 12.3 0.1 0.97 9.6 0.1 2.4 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Spc7 PF08317.11 EWC43541.1 - 0.52 9.1 5.9 1.4 7.7 5.9 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein UQ_con PF00179.26 EWC43542.1 - 3.6e-50 169.3 0.0 4.1e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EWC43542.1 - 0.0031 17.4 0.0 0.0044 16.9 0.0 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 EWC43542.1 - 0.0075 16.5 0.0 0.016 15.5 0.0 1.4 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EWC43542.1 - 0.063 13.0 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Pkinase PF00069.25 EWC43543.1 - 1.4e-64 218.1 0.0 1.9e-64 217.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43543.1 - 8e-32 110.5 0.0 1.2e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC43543.1 - 2.1e-07 30.5 0.0 3.1e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EWC43543.1 - 0.033 13.3 0.0 0.057 12.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EWC43543.1 - 0.046 13.6 0.0 0.18 11.7 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EWC43543.1 - 0.082 11.8 1.0 0.1 11.5 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain Ost5 PF05251.12 EWC43546.1 - 0.14 12.5 8.8 0.29 11.4 2.2 3.2 3 0 0 3 3 3 0 Oligosaccharyltransferase subunit 5 INO80_Ies4 PF08193.11 EWC43547.1 - 2.5e-36 125.9 11.4 2.5e-36 125.9 11.4 1.7 1 1 1 2 2 2 1 INO80 complex subunit Ies4 RSF PF14876.6 EWC43547.1 - 0.25 10.3 1.0 0.46 9.4 1.0 1.3 1 0 0 1 1 1 0 Respiratory growth transcriptional regulator Peptidase_S8 PF00082.22 EWC43548.1 - 1.9e-32 112.7 3.0 4.2e-32 111.6 3.0 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EWC43548.1 - 0.019 15.6 0.0 0.032 14.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 Glyco_hydro_16 PF00722.21 EWC43549.1 - 6.1e-43 146.3 5.9 9.8e-43 145.7 5.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Conotoxin PF02950.17 EWC43549.1 - 0.17 12.9 2.1 0.37 11.8 2.1 1.5 1 0 0 1 1 1 0 Conotoxin Chitin_bind_1 PF00187.19 EWC43549.1 - 1.2 9.6 20.8 0.07 13.6 15.2 1.8 2 0 0 2 2 2 0 Chitin recognition protein AKAP7_NLS PF10469.9 EWC43550.1 - 4.7e-20 72.4 0.0 6.2e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Glyco_hydro_76 PF03663.14 EWC43551.1 - 6.8e-23 81.8 4.4 5.7e-22 78.7 4.4 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EWC43551.1 - 0.0056 15.8 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 DUF498 PF04430.14 EWC43552.1 - 1e-26 93.1 0.0 1.4e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) PA26 PF04636.13 EWC43553.1 - 2.6e-73 247.4 0.0 6.1e-47 160.5 0.0 3.1 3 0 0 3 3 3 3 PA26 p53-induced protein (sestrin) NIF PF03031.18 EWC43554.1 - 2.4e-43 147.6 0.0 3.2e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase COX5B PF01215.19 EWC43555.1 - 9.2e-51 170.9 0.0 1.2e-50 170.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb CTNNB1_binding PF08347.11 EWC43555.1 - 0.082 13.1 0.0 0.097 12.8 0.0 1.2 1 0 0 1 1 1 0 N-terminal CTNNB1 binding PROCN PF08083.11 EWC43556.1 - 7.3e-231 766.0 6.4 1.1e-230 765.4 6.4 1.2 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EWC43556.1 - 7.9e-124 411.8 0.9 1.4e-123 410.9 0.9 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EWC43556.1 - 1.9e-84 281.4 1.1 5.2e-84 280.0 1.1 1.8 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EWC43556.1 - 2.5e-79 264.5 3.1 5.6e-79 263.4 3.1 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EWC43556.1 - 5.7e-71 236.8 0.1 1.1e-70 235.9 0.1 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EWC43556.1 - 5.3e-47 158.1 0.2 1.3e-46 156.9 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EWC43556.1 - 6e-43 145.7 0.0 2.1e-42 143.9 0.0 2.0 2 0 0 2 2 2 1 PROCT (NUC072) domain JAB PF01398.21 EWC43556.1 - 0.00018 21.5 0.1 0.00046 20.2 0.1 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ribosomal_L34e PF01199.18 EWC43557.1 - 9.8e-43 144.4 2.9 1.3e-42 144.0 2.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e XLF PF09302.11 EWC43558.1 - 1.2e-45 155.9 0.4 2.7e-45 154.7 0.0 1.8 2 0 0 2 2 2 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Forkhead PF00250.18 EWC43559.1 - 1.4e-26 92.6 0.0 4.4e-26 90.9 0.0 1.8 2 0 0 2 2 2 1 Forkhead domain Med3 PF11593.8 EWC43559.1 - 0.005 16.1 1.4 0.007 15.6 1.4 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Cactin_mid PF10312.9 EWC43560.1 - 9.2e-65 218.1 6.7 1.7e-64 217.2 6.7 1.5 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EWC43560.1 - 2.8e-57 192.1 4.4 4.9e-57 191.3 4.4 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein SAYSvFN PF10260.9 EWC43561.1 - 9.2e-26 89.6 0.4 1.2e-25 89.2 0.4 1.2 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) ADH_zinc_N PF00107.26 EWC43564.1 - 1.6e-21 76.6 0.4 2.7e-21 75.9 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EWC43564.1 - 6.7e-13 49.8 0.0 1.2e-12 49.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EWC43564.1 - 7.7e-09 35.4 0.0 9.8e-08 31.9 0.0 2.4 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain Senescence PF06911.12 EWC43565.1 - 9e-27 94.6 9.0 1.1e-26 94.2 9.0 1.1 1 0 0 1 1 1 1 Senescence-associated protein Ribosomal_S19e PF01090.19 EWC43566.1 - 1.8e-58 196.1 0.1 2e-58 196.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e DUF805 PF05656.14 EWC43568.1 - 0.056 13.9 16.3 0.12 12.8 4.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF805) zf-C2H2_4 PF13894.6 EWC43569.1 - 2.9e-05 24.5 3.9 0.12 13.3 0.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EWC43569.1 - 0.029 14.8 4.5 0.078 13.5 0.1 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Abhydrolase_6 PF12697.7 EWC43570.1 - 4.5e-18 66.7 0.0 7.2e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EWC43570.1 - 2.1e-14 53.8 0.1 4.1e-12 46.3 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC43570.1 - 1.3e-13 50.8 0.0 3e-13 49.6 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DSPc PF00782.20 EWC43570.1 - 1.9e-10 40.7 0.0 3.9e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain BAAT_C PF08840.11 EWC43570.1 - 0.0023 17.9 0.2 0.0053 16.7 0.0 1.6 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Y_phosphatase PF00102.27 EWC43570.1 - 0.004 16.8 0.0 0.0073 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Peptidase_S9 PF00326.21 EWC43570.1 - 0.0068 15.9 0.1 0.019 14.4 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family PTPlike_phytase PF14566.6 EWC43570.1 - 0.0088 16.2 0.0 0.026 14.7 0.0 1.6 1 1 0 2 2 2 1 Inositol hexakisphosphate Abhydrolase_4 PF08386.10 EWC43570.1 - 0.027 14.6 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein LCAT PF02450.15 EWC43570.1 - 0.072 12.2 0.0 0.74 8.9 0.0 2.0 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase DLH PF01738.18 EWC43570.1 - 0.11 12.1 0.1 4.5 6.8 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family PGAP1 PF07819.13 EWC43570.1 - 0.13 11.9 0.1 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein Thioesterase PF00975.20 EWC43570.1 - 0.13 12.3 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.25 EWC43570.1 - 0.15 11.9 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) ILVD_EDD PF00920.21 EWC43571.1 - 1.1e-207 690.7 0.0 1.3e-207 690.5 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family Glyco_hydro_61 PF03443.14 EWC43572.1 - 3e-52 177.6 0.0 3e-52 177.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EWC43572.1 - 1.5e-12 47.3 6.6 5e-12 45.5 6.6 2.1 1 0 0 1 1 1 1 Fungal cellulose binding domain E1-E2_ATPase PF00122.20 EWC43573.1 - 5.6e-33 114.0 7.7 6.4e-25 87.7 0.1 4.1 5 0 0 5 5 5 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EWC43573.1 - 2.5e-28 99.0 1.5 2.5e-28 99.0 1.5 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EWC43573.1 - 7.1e-22 77.3 0.0 3.4e-21 75.1 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EWC43573.1 - 1.1e-18 66.6 0.1 3.7e-18 65.0 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 EWC43573.1 - 2.4e-17 63.9 0.0 3.3e-16 60.2 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EWC43573.1 - 0.00043 20.1 1.0 0.0035 17.1 0.5 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EWC43573.1 - 0.0011 19.4 0.1 0.0036 17.7 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DctM PF06808.12 EWC43573.1 - 0.0022 16.9 2.1 0.0033 16.3 0.1 2.0 2 0 0 2 2 2 1 Tripartite ATP-independent periplasmic transporter, DctM component RPOL_N PF14700.6 EWC43573.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal NVEALA PF14055.6 EWC43573.1 - 0.73 9.9 0.0 0.73 9.9 0.0 2.2 2 0 0 2 2 2 0 NVEALA protein IMPDH PF00478.25 EWC43574.1 - 6.6e-131 436.4 4.0 8e-131 436.1 4.0 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EWC43574.1 - 1.4e-11 44.6 0.4 0.00025 21.4 0.1 2.7 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 EWC43574.1 - 2.6e-07 30.0 1.4 3.7e-06 26.2 0.6 2.3 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EWC43574.1 - 0.00056 19.4 5.2 0.037 13.4 3.6 2.8 3 1 0 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 EWC43574.1 - 0.0051 16.3 4.2 0.072 12.5 0.2 2.7 2 1 1 3 3 3 2 Histidine biosynthesis protein PcrB PF01884.17 EWC43574.1 - 0.12 11.8 0.6 6.4 6.2 0.0 3.1 3 0 0 3 3 3 0 PcrB family SH3BGR PF04908.15 EWC43575.1 - 6.2e-06 26.3 0.0 1.3e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 EWC43575.1 - 0.0058 16.8 0.0 0.021 15.0 0.0 1.9 2 0 0 2 2 2 1 Glutaredoxin GST_N_3 PF13417.6 EWC43575.1 - 0.011 16.1 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EWC43575.1 - 0.033 14.5 0.0 0.068 13.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EWC43576.1 - 1.1e-11 44.7 0.0 1.9e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EWC43576.1 - 1.2e-11 44.6 0.0 2.4e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EWC43576.1 - 1.5e-11 44.4 0.0 3.1e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EWC43576.1 - 1.9e-10 41.0 0.0 3.7e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EWC43576.1 - 6.5e-10 39.2 0.0 1.9e-09 37.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EWC43576.1 - 1.2e-08 34.8 0.1 2.2e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain AAA_15 PF13175.6 EWC43579.1 - 0.29 10.8 4.9 0.83 9.3 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain Kinesin PF00225.23 EWC43581.1 - 1.3e-115 385.8 0.0 2.2e-115 385.2 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EWC43581.1 - 5e-27 94.7 0.0 1e-26 93.6 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding AAA_33 PF13671.6 EWC43581.1 - 0.032 14.4 0.0 0.15 12.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain PPI_Ypi1 PF07491.11 EWC43581.1 - 0.043 13.6 0.3 0.12 12.2 0.3 1.7 1 0 0 1 1 1 0 Protein phosphatase inhibitor AAA_16 PF13191.6 EWC43581.1 - 0.15 12.4 0.3 0.83 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Laminin_II PF06009.12 EWC43581.1 - 1.2 9.2 8.9 1.2 9.2 1.7 3.7 4 0 0 4 4 4 0 Laminin Domain II SHE3 PF17078.5 EWC43581.1 - 2.6 7.7 9.1 0.29 10.8 2.6 2.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 AAA_13 PF13166.6 EWC43581.1 - 7.4 5.1 9.4 1.6 7.2 2.0 2.2 2 0 0 2 2 2 0 AAA domain RRM_1 PF00076.22 EWC43582.1 - 2.9e-16 59.1 0.0 4.4e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EWC43582.1 - 0.00059 19.4 0.0 0.00086 18.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EWC43582.1 - 0.0013 18.8 0.1 0.0018 18.3 0.1 1.2 1 0 0 1 1 1 1 RNA binding motif Myb_DNA-binding PF00249.31 EWC43583.1 - 6.9e-16 58.2 2.7 5.7e-09 36.0 0.9 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EWC43583.1 - 4.6e-09 36.4 3.8 5.9e-05 23.2 1.9 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF3292 PF11696.8 EWC43583.1 - 0.0024 16.3 5.1 0.0038 15.7 5.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) Myb_DNA-bind_7 PF15963.5 EWC43583.1 - 0.0064 16.4 1.2 0.0097 15.8 1.2 1.3 1 0 0 1 1 1 1 Myb DNA-binding like ALGX PF16822.5 EWC43583.1 - 0.012 15.3 1.7 0.016 14.9 1.0 1.5 1 1 0 1 1 1 0 SGNH hydrolase-like domain, acetyltransferase AlgX Ndc1_Nup PF09531.10 EWC43583.1 - 0.93 8.1 10.0 1.1 7.8 10.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Malic_M PF03949.15 EWC43585.1 - 2.1e-89 299.2 0.1 2.8e-89 298.8 0.1 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EWC43585.1 - 1.4e-63 214.0 0.0 2.1e-63 213.4 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Myb_DNA-binding PF00249.31 EWC43586.1 - 1.9e-06 28.0 1.3 0.00038 20.6 0.5 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EWC43586.1 - 0.00028 21.1 0.9 0.032 14.5 0.5 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain G_path_suppress PF15991.5 EWC43586.1 - 0.16 12.1 4.2 0.25 11.4 4.2 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor RNA_pol_Rpc34 PF05158.12 EWC43587.1 - 3.1e-92 309.5 0.0 6.6e-91 305.2 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit HxlR PF01638.17 EWC43587.1 - 0.0086 15.9 0.2 0.027 14.3 0.2 1.9 2 1 0 2 2 2 1 HxlR-like helix-turn-helix PPTA PF01239.22 EWC43588.1 - 0.00024 20.7 10.8 0.0073 16.0 0.3 3.3 4 0 0 4 4 4 2 Protein prenyltransferase alpha subunit repeat Kelch_4 PF13418.6 EWC43589.1 - 2.3e-25 88.3 15.3 3.1e-08 33.5 0.0 6.6 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EWC43589.1 - 4.6e-22 77.8 12.8 2.3e-07 30.9 0.1 6.6 7 0 0 7 7 7 3 Galactose oxidase, central domain DUF4110 PF13422.6 EWC43589.1 - 2.7e-21 75.5 0.9 2.7e-21 75.5 0.9 4.2 5 1 1 6 6 3 1 Domain of unknown function (DUF4110) Kelch_5 PF13854.6 EWC43589.1 - 1.4e-15 56.9 3.0 4.7e-05 23.3 0.1 6.3 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 EWC43589.1 - 1.6e-13 50.4 11.3 1e-06 28.8 0.1 5.6 5 1 1 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EWC43589.1 - 3.1e-12 46.0 6.6 2.1e-05 24.3 0.0 6.1 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 EWC43589.1 - 8.2e-12 44.5 8.3 2e-06 27.3 0.0 4.9 5 0 0 5 5 4 2 Kelch motif YL1 PF05764.13 EWC43589.1 - 2.8e-05 24.4 9.3 2.8e-05 24.4 9.3 2.7 3 0 0 3 3 2 1 YL1 nuclear protein Nop14 PF04147.12 EWC43589.1 - 0.00033 19.0 9.2 0.00033 19.0 9.2 2.1 2 0 0 2 2 2 1 Nop14-like family CDC45 PF02724.14 EWC43589.1 - 0.0018 16.7 7.2 0.0018 16.7 7.2 2.1 2 0 0 2 2 2 1 CDC45-like protein SDA1 PF05285.12 EWC43589.1 - 0.0024 17.4 14.8 0.0024 17.4 14.8 2.3 2 0 0 2 2 1 1 SDA1 BUD22 PF09073.10 EWC43589.1 - 0.39 10.0 26.3 0.012 15.0 9.6 2.3 2 0 0 2 2 2 0 BUD22 TEX19 PF15553.6 EWC43589.1 - 0.44 10.5 5.9 1.1 9.2 5.9 1.6 1 0 0 1 1 1 0 Testis-expressed protein 19 PI3K_1B_p101 PF10486.9 EWC43589.1 - 0.7 7.6 3.9 1.4 6.6 3.9 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Rrn6 PF10214.9 EWC43589.1 - 6.8 5.0 9.9 2 6.8 3.1 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Mpp10 PF04006.12 EWC43589.1 - 9.6 4.5 27.8 0.0063 15.0 10.4 2.1 2 0 0 2 2 2 0 Mpp10 protein DUF2151 PF10221.9 EWC43589.1 - 9.7 4.6 8.1 1.3 7.5 1.5 2.0 2 0 0 2 2 2 0 Cell cycle and development regulator Oxysterol_BP PF01237.18 EWC43590.1 - 2e-87 293.5 0.0 9e-85 284.7 0.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Tim17 PF02466.19 EWC43591.1 - 0.006 17.0 3.6 0.0078 16.6 3.1 1.6 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family MHYT PF03707.16 EWC43592.1 - 3.6e-28 97.5 17.0 3.4e-13 49.5 0.7 4.5 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat HATPase_c PF02518.26 EWC43592.1 - 4.5e-27 94.8 0.0 1e-26 93.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EWC43592.1 - 2.4e-18 66.3 0.0 6.4e-18 64.9 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EWC43592.1 - 3.1e-14 52.7 0.0 8.5e-14 51.3 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 EWC43592.1 - 0.05 13.6 0.0 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain PMSR PF01625.21 EWC43593.1 - 2.7e-58 196.5 2.9 3.3e-58 196.2 2.9 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Phage_GPA PF05840.13 EWC43593.1 - 0.027 13.6 0.1 0.036 13.2 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage replication gene A protein (GPA) TPR_1 PF00515.28 EWC43594.1 - 2e-47 157.2 19.1 2.6e-07 30.2 0.0 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EWC43594.1 - 3.2e-39 129.9 18.7 1.3e-05 24.9 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 EWC43594.1 - 6.2e-32 109.3 13.6 1.5e-17 63.3 4.8 3.0 3 0 0 3 3 2 2 STI1 domain TPR_12 PF13424.6 EWC43594.1 - 2e-21 76.0 14.5 6.8e-11 42.3 1.1 6.6 3 3 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EWC43594.1 - 4.5e-19 67.0 20.7 0.00026 20.9 0.1 8.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 EWC43594.1 - 1.2e-18 66.2 14.4 0.12 13.3 0.1 8.9 5 3 4 9 9 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 EWC43594.1 - 1.7e-18 66.0 14.1 0.001 18.7 1.0 7.7 6 2 2 8 8 8 5 TPR repeat TPR_7 PF13176.6 EWC43594.1 - 4.8e-16 57.5 4.3 2.8e-05 23.8 0.0 6.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EWC43594.1 - 3.6e-13 49.8 8.0 0.074 13.6 0.0 7.0 6 1 0 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 EWC43594.1 - 7.4e-13 48.9 11.0 0.12 13.0 0.0 6.4 4 2 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 EWC43594.1 - 1.2e-12 47.2 1.4 0.14 12.6 0.0 8.2 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 EWC43594.1 - 5.3e-12 45.2 5.7 0.027 14.3 0.1 6.5 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EWC43594.1 - 3.9e-08 33.3 1.1 0.11 12.7 0.1 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EWC43594.1 - 1.2e-07 31.9 9.1 0.038 14.6 0.2 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_3 PF07720.12 EWC43594.1 - 1.6e-05 24.7 3.7 0.39 10.8 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EWC43594.1 - 0.00014 21.9 2.6 21 5.3 0.1 6.0 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EWC43594.1 - 0.00067 19.8 10.1 0.23 11.7 0.9 4.7 3 2 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3274 PF11678.8 EWC43594.1 - 0.00076 18.8 0.8 0.0017 17.7 0.8 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3274) RPN7 PF10602.9 EWC43594.1 - 0.017 14.8 8.4 1.6 8.4 0.0 4.4 3 2 0 4 4 4 0 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 EWC43594.1 - 0.71 9.4 3.7 4.6 6.8 0.0 4.1 5 0 0 5 5 5 0 SHNi-TPR TPR_20 PF14561.6 EWC43594.1 - 2.3 8.6 11.5 2.5 8.5 0.2 4.7 5 2 2 7 7 4 0 Tetratricopeptide repeat cNMPbd_u2 PF16643.5 EWC43595.1 - 2.4e-32 112.6 9.4 2.4e-32 112.6 9.4 2.0 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein cNMP_binding PF00027.29 EWC43595.1 - 3.3e-32 110.4 0.0 6.9e-19 67.7 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_4 PF12799.7 EWC43595.1 - 7.1e-11 42.2 0.0 0.0047 17.3 0.0 5.8 6 0 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EWC43595.1 - 2.9e-07 30.0 5.7 12 6.2 0.0 8.4 9 0 0 9 9 9 2 Leucine Rich repeat F-box PF00646.33 EWC43595.1 - 1.1e-06 28.3 0.8 3.3e-05 23.6 0.3 2.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EWC43595.1 - 0.00012 21.9 0.8 0.0006 19.6 0.1 2.6 3 0 0 3 3 3 1 F-box-like LRR_1 PF00560.33 EWC43595.1 - 0.0017 18.6 4.1 81 4.4 0.2 7.2 8 1 0 8 8 8 0 Leucine Rich Repeat Cupin_3 PF05899.12 EWC43595.1 - 0.01 15.5 0.1 1.5 8.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF861) CHAT PF12770.7 EWC43596.1 - 3.8e-15 56.1 0.0 6.7e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 CHAT domain DUF4164 PF13747.6 EWC43597.1 - 0.0014 18.8 11.1 0.014 15.6 6.2 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4164) CEP209_CC5 PF16574.5 EWC43597.1 - 0.004 17.3 3.9 0.004 17.3 3.9 2.0 1 1 1 2 2 2 1 Coiled-coil region of centrosome protein CE290 MCRS_N PF13325.6 EWC43597.1 - 0.0099 15.9 1.4 0.49 10.4 0.1 2.6 2 0 0 2 2 2 1 N-terminal region of micro-spherule protein LPP PF04728.13 EWC43597.1 - 0.047 14.1 3.1 2.7 8.4 0.2 3.4 2 1 1 3 3 3 0 Lipoprotein leucine-zipper MbeD_MobD PF04899.12 EWC43597.1 - 0.049 13.7 4.2 0.048 13.8 0.9 2.9 4 0 0 4 4 2 0 MbeD/MobD like TetR_C_22 PF17928.1 EWC43597.1 - 0.052 13.9 0.8 3.9 7.8 0.0 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain AAA_13 PF13166.6 EWC43597.1 - 0.094 11.3 7.8 0.13 10.9 7.8 1.2 1 0 0 1 1 1 0 AAA domain Vps54_N PF10475.9 EWC43597.1 - 0.18 11.1 4.9 0.29 10.4 4.9 1.3 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Rootletin PF15035.6 EWC43597.1 - 0.18 11.8 12.3 0.45 10.5 12.3 1.6 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Fez1 PF06818.15 EWC43597.1 - 0.27 11.7 13.2 0.59 10.6 12.9 1.7 1 1 0 1 1 1 0 Fez1 DUF4407 PF14362.6 EWC43597.1 - 0.27 10.5 5.6 0.55 9.5 5.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1690 PF07956.11 EWC43597.1 - 0.49 10.8 7.5 0.84 10.1 6.3 2.1 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) FlaC_arch PF05377.11 EWC43597.1 - 0.53 10.7 2.5 14 6.2 1.0 3.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Fzo_mitofusin PF04799.13 EWC43597.1 - 0.87 9.1 7.6 0.055 13.0 1.9 1.9 2 0 0 2 2 2 0 fzo-like conserved region SlyX PF04102.12 EWC43597.1 - 2.2 8.9 13.2 3.7 8.2 1.5 4.4 2 2 1 4 4 4 0 SlyX TMF_DNA_bd PF12329.8 EWC43597.1 - 2.3 8.3 12.0 5.8 7.0 0.4 3.5 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding ABC_tran_CTD PF16326.5 EWC43597.1 - 2.7 8.3 13.1 0.71 10.2 0.1 3.6 2 1 1 3 3 2 0 ABC transporter C-terminal domain Lzipper-MIP1 PF14389.6 EWC43597.1 - 5.4 7.4 9.7 1.2 9.5 4.4 2.7 3 0 0 3 3 2 0 Leucine-zipper of ternary complex factor MIP1 TolA_bind_tri PF16331.5 EWC43597.1 - 5.8 7.1 9.9 0.36 10.9 1.3 3.1 2 1 0 2 2 2 0 TolA binding protein trimerisation zf-C4H2 PF10146.9 EWC43597.1 - 6.4 7.0 17.0 1.2e+02 2.9 17.0 2.5 1 1 0 1 1 1 0 Zinc finger-containing protein NUDIX PF00293.28 EWC43598.1 - 5.3e-10 39.4 0.0 8.2e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain C2 PF00168.30 EWC43599.1 - 3.7e-83 274.5 0.3 9e-22 77.3 0.0 5.4 5 0 0 5 5 5 4 C2 domain LST1 PF05083.13 EWC43599.1 - 0.057 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 LST-1 protein 2OG-FeII_Oxy PF03171.20 EWC43600.1 - 1.2e-07 32.1 0.0 5.4e-07 30.0 0.0 2.1 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily HJURP_C PF12347.8 EWC43601.1 - 2 8.5 4.0 0.59 10.2 0.6 1.9 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat MFS_1 PF07690.16 EWC43602.1 - 4.9e-39 134.3 25.8 3.8e-30 105.0 0.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC43602.1 - 2.1e-08 33.5 2.0 2.1e-08 33.5 2.0 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EWC43602.1 - 0.0057 15.1 0.8 0.0057 15.1 0.8 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.18 EWC43603.1 - 4.6e-16 58.6 1.5 4.8e-16 58.6 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC43603.1 - 1.3e-07 31.6 10.3 2.5e-07 30.7 10.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PIG-Y PF15159.6 EWC43603.1 - 0.07 14.1 0.2 3.4 8.7 0.0 2.6 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PAT1 PF09770.9 EWC43603.1 - 0.073 11.3 17.5 0.1 10.9 17.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF2909 PF11137.8 EWC43603.1 - 0.13 12.2 0.1 0.58 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) LRRFIP PF09738.9 EWC43603.1 - 0.35 10.3 0.0 0.35 10.3 0.0 2.5 3 0 0 3 3 3 0 LRRFIP family Chorion_2 PF03964.15 EWC43603.1 - 2.5 9.0 10.5 0.47 11.3 5.7 2.3 2 0 0 2 2 2 0 Chorion family 2 TFIIA PF03153.13 EWC43603.1 - 4 7.3 28.0 8.2 6.3 28.0 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CGI-121 PF08617.10 EWC43604.1 - 2e-49 167.9 0.0 2.2e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 F-box PF00646.33 EWC43605.1 - 1.2e-05 25.0 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EWC43605.1 - 0.0022 17.9 0.0 0.0046 16.8 0.0 1.4 1 0 0 1 1 1 1 F-box-like HMG-CoA_red PF00368.18 EWC43606.1 - 3e-142 474.0 4.1 4.6e-142 473.4 4.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EWC43606.1 - 1e-17 64.4 0.2 2e-17 63.5 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EWC43606.1 - 6.9e-13 48.7 3.8 4.3e-12 46.1 3.8 2.2 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EWC43606.1 - 1.1e-05 23.8 0.4 2e-05 22.9 0.4 1.3 1 0 0 1 1 1 1 Patched family Ribosomal_S21e PF01249.18 EWC43607.1 - 6.2e-41 138.4 0.1 6.9e-41 138.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e F-box-like PF12937.7 EWC43608.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 F-box-like SH3_1 PF00018.28 EWC43609.1 - 6.9e-10 38.4 0.0 1.3e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC43609.1 - 1.5e-09 37.5 0.2 2.8e-09 36.7 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EWC43609.1 - 8.1e-06 25.4 0.0 1.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ssu72 PF04722.13 EWC43610.1 - 5.6e-85 283.7 0.0 6.4e-85 283.5 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein GIT_SHD PF08518.11 EWC43611.1 - 7.3e-25 86.3 9.3 1.8e-13 49.8 2.5 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GTP-bdg_M PF16360.5 EWC43611.1 - 0.018 15.6 1.5 0.018 15.6 1.5 3.3 3 1 0 3 3 2 0 GTP-binding GTPase Middle Region DUF2935 PF11155.8 EWC43611.1 - 0.091 13.1 0.0 9.1 6.6 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF3573 PF12097.8 EWC43611.1 - 0.22 10.3 2.7 0.59 8.9 2.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Rootletin PF15035.6 EWC43611.1 - 0.23 11.5 30.1 0.24 11.4 14.6 3.0 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion Nup54_57_C PF18570.1 EWC43611.1 - 0.27 10.9 0.9 2.4 7.8 0.5 2.4 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain Atg14 PF10186.9 EWC43611.1 - 1.8 7.6 19.0 1.4 8.0 10.4 3.1 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF948 PF06103.11 EWC43611.1 - 2.7 8.3 7.0 43 4.4 0.6 3.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1843 PF08898.10 EWC43611.1 - 6.8 7.3 6.5 4.1 8.0 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) NPV_P10 PF05531.12 EWC43611.1 - 7.7 7.1 6.0 8.2 7.0 1.7 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 EWC43611.1 - 9.4 5.0 33.6 1.3 7.9 2.8 3.1 3 0 0 3 3 3 0 Spc7 kinetochore protein Transp_cyt_pur PF02133.15 EWC43612.1 - 1.8e-47 162.2 32.0 2.2e-47 161.8 32.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Phage_holin_4_1 PF05105.12 EWC43612.1 - 0.089 12.9 1.2 0.19 11.9 0.3 2.1 2 0 0 2 2 2 0 Bacteriophage holin family DUF1129 PF06570.11 EWC43612.1 - 4.6 6.7 5.6 13 5.2 1.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) Cellulase PF00150.18 EWC43613.1 - 5.6e-15 55.5 0.6 9.2e-15 54.8 0.0 1.5 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 EWC43613.1 - 0.0029 17.0 0.1 0.038 13.3 0.1 2.3 2 0 0 2 2 2 1 Beta-galactosidase AAA_23 PF13476.6 EWC43614.1 - 8.7e-34 117.8 3.3 8.7e-34 117.8 3.3 7.7 2 1 3 5 5 5 1 AAA domain AAA_21 PF13304.6 EWC43614.1 - 7.2e-08 32.6 8.4 0.0018 18.2 0.0 4.3 4 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EWC43614.1 - 1.7e-05 25.0 0.0 5e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 EWC43614.1 - 0.00014 21.3 46.4 0.0011 18.4 46.4 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EWC43614.1 - 0.00083 19.1 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EWC43614.1 - 0.00085 19.1 54.2 1.8e+04 -19.1 54.2 4.9 1 1 0 1 1 1 0 AAA ATPase domain Tup_N PF08581.10 EWC43614.1 - 0.0089 16.3 1.6 0.0089 16.3 1.6 9.8 6 4 4 10 10 10 1 Tup N-terminal AAA_16 PF13191.6 EWC43614.1 - 0.075 13.4 0.0 0.075 13.4 0.0 5.3 5 1 1 6 6 6 0 AAA ATPase domain AAA_13 PF13166.6 EWC43614.1 - 0.076 11.6 0.0 0.076 11.6 0.0 7.6 3 1 5 8 8 8 0 AAA domain GATA PF00320.27 EWC43615.1 - 9.9e-16 57.1 6.1 2e-15 56.1 6.1 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 EWC43615.1 - 6.5e-13 48.8 0.1 1.3e-12 47.8 0.1 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EWC43615.1 - 4.3e-11 42.8 0.4 9.5e-11 41.7 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 EWC43615.1 - 2.2e-08 34.2 0.0 5.1e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EWC43615.1 - 2.3e-07 31.0 0.1 1e-06 28.9 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EWC43615.1 - 1.3e-05 25.4 0.0 2.7e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold Zn-ribbon_8 PF09723.10 EWC43615.1 - 0.0062 16.6 0.2 0.013 15.6 0.2 1.5 1 0 0 1 1 1 1 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 EWC43615.1 - 0.04 13.4 0.8 0.24 10.9 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding MscS_TM PF12794.7 EWC43616.1 - 0.01 14.7 11.0 0.1 11.4 0.6 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 LRR19-TM PF15176.6 EWC43616.1 - 0.48 10.5 0.0 0.48 10.5 0.0 2.4 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain TctB PF07331.11 EWC43616.1 - 1.5 9.1 21.1 20 5.5 15.3 3.6 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family Oxidored_q3 PF00499.20 EWC43616.1 - 2.7 7.7 15.0 0.097 12.4 2.9 3.0 1 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 NPR2 PF06218.11 EWC43617.1 - 1.9e-116 389.4 7.1 3.1e-64 217.4 0.9 3.0 1 1 2 3 3 3 3 Nitrogen permease regulator 2 NPR3 PF03666.13 EWC43617.1 - 0.00016 20.7 0.2 0.28 9.9 0.1 2.9 2 1 1 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 PqqD PF05402.12 EWC43617.1 - 0.13 12.6 0.1 6.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) ADH_N_2 PF16884.5 EWC43618.1 - 4.2e-23 81.3 0.0 8.6e-23 80.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EWC43618.1 - 3.9e-17 62.5 0.1 5.7e-17 61.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EWC43618.1 - 0.00076 20.5 0.0 0.0014 19.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 EWC43618.1 - 0.088 12.5 0.6 1 9.0 0.1 2.1 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Maf PF02545.14 EWC43619.1 - 1.8e-49 167.8 0.0 2.7e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Maf-like protein TFR_dimer PF04253.15 EWC43621.1 - 5.6e-24 84.6 0.0 1e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EWC43621.1 - 1.5e-19 70.4 0.9 2.1e-17 63.5 0.9 2.4 1 1 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EWC43621.1 - 2.3e-11 43.5 0.0 1.7e-10 40.7 0.0 2.3 2 0 0 2 2 2 1 PA domain Nicastrin PF05450.15 EWC43621.1 - 0.017 14.6 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Nicastrin MFS_1 PF07690.16 EWC43622.1 - 2.8e-16 59.4 20.1 2.8e-16 59.4 20.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 EWC43623.1 - 4.7e-05 23.4 10.9 8.5e-05 22.6 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EWC43623.1 - 0.011 14.8 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Macoilin PF09726.9 EWC43623.1 - 0.043 12.4 5.0 0.07 11.7 5.0 1.2 1 0 0 1 1 1 0 Macoilin family PAC3 PF10178.9 EWC43624.1 - 0.0021 18.1 0.0 0.0058 16.7 0.0 1.8 2 0 0 2 2 2 1 Proteasome assembly chaperone 3 GCSF PF16647.5 EWC43624.1 - 0.023 14.5 0.5 0.067 13.0 0.1 1.8 2 0 0 2 2 2 0 Granulocyte colony-stimulating factor SNF2_N PF00176.23 EWC43625.1 - 6.8e-50 169.7 0.0 1.2e-49 169.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 EWC43625.1 - 8.3e-23 80.3 1.3 3.8e-22 78.2 1.3 2.3 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 EWC43625.1 - 2.3e-21 76.2 0.0 6.2e-21 74.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Rad1 PF02144.16 EWC43626.1 - 8.7e-62 208.7 0.1 4.5e-36 124.3 0.1 2.1 2 0 0 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Ank_2 PF12796.7 EWC43627.1 - 1.1e-42 144.5 17.0 1.6e-12 47.8 0.1 5.6 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC43627.1 - 1.4e-30 105.3 5.2 9.1e-07 29.3 0.1 8.2 5 1 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC43627.1 - 6.8e-27 90.6 8.4 0.037 14.6 0.0 10.1 10 0 0 10 10 9 7 Ankyrin repeat Ank PF00023.30 EWC43627.1 - 4.8e-25 86.8 18.3 0.0041 17.5 0.0 10.1 10 0 0 10 10 9 7 Ankyrin repeat Ank_5 PF13857.6 EWC43627.1 - 1.1e-16 60.6 8.4 4.1e-05 23.8 0.1 6.7 3 2 3 6 6 6 3 Ankyrin repeats (many copies) NACHT PF05729.12 EWC43627.1 - 3.8e-11 43.2 0.1 6.9e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EWC43627.1 - 3.9e-08 33.9 0.2 4.2e-07 30.5 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain ATPase_2 PF01637.18 EWC43627.1 - 7.4e-07 29.3 0.0 1.8e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EWC43627.1 - 1.2e-05 25.6 0.5 7.5e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain PNP_UDP_1 PF01048.20 EWC43627.1 - 2.3e-05 23.8 0.0 6.5e-05 22.3 0.0 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_14 PF13173.6 EWC43627.1 - 0.00011 22.2 0.6 0.0008 19.4 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EWC43627.1 - 0.0042 17.5 0.0 0.014 15.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EWC43627.1 - 0.0081 16.5 0.1 0.068 13.6 0.0 2.4 2 0 0 2 2 2 1 RNA helicase KAP_NTPase PF07693.14 EWC43627.1 - 0.0084 15.4 0.0 2.2 7.4 0.0 2.4 1 1 1 2 2 2 2 KAP family P-loop domain NB-ARC PF00931.22 EWC43627.1 - 0.016 14.4 0.0 0.055 12.7 0.0 1.8 1 1 0 1 1 1 0 NB-ARC domain ATPase PF06745.13 EWC43627.1 - 0.075 12.4 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 KaiC COG5 PF10392.9 EWC43627.1 - 0.12 12.5 0.6 0.29 11.3 0.6 1.6 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF1843 PF08898.10 EWC43627.1 - 1.8 9.1 7.0 12 6.5 0.1 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) Pro_isomerase PF00160.21 EWC43628.1 - 6.4e-47 159.7 0.5 7.2e-47 159.6 0.5 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF155 PF02582.14 EWC43629.1 - 4.3e-55 186.5 0.0 7.5e-55 185.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 RGS PF00615.19 EWC43630.1 - 1e-13 51.6 0.0 2.1e-10 40.9 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain RTBV_P46 PF06216.11 EWC43631.1 - 0.037 12.9 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein FAM86 PF14904.6 EWC43632.1 - 0.13 12.4 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function Bromodomain PF00439.25 EWC43633.1 - 5e-23 81.0 0.5 9.7e-23 80.0 0.5 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EWC43633.1 - 6e-08 32.9 0.0 1.2e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC43633.1 - 1.2e-06 28.4 0.0 2.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC43633.1 - 0.00087 19.7 0.1 0.0016 18.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Sugar_tr PF00083.24 EWC43634.1 - 2.9e-84 283.5 25.8 3.3e-84 283.4 25.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC43634.1 - 2.8e-28 98.9 33.0 2.8e-28 98.9 33.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EWC43634.1 - 0.0055 15.0 18.4 0.01 14.1 2.0 2.9 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Peptidase_S8 PF00082.22 EWC43635.1 - 4.2e-31 108.3 6.0 6.5e-31 107.7 3.9 2.1 2 1 0 2 2 2 1 Subtilase family Peptidase_M28 PF04389.17 EWC43637.1 - 8.9e-38 130.0 0.0 1.6e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EWC43637.1 - 7.3e-13 48.3 1.3 1.6e-12 47.3 1.3 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EWC43637.1 - 0.00045 20.0 0.0 0.00087 19.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF1349 PF07081.11 EWC43638.1 - 9.9e-17 61.2 0.0 2.3e-16 60.0 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) CLTH PF10607.9 EWC43639.1 - 6.4e-33 113.7 0.0 1.4e-32 112.6 0.0 1.6 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EWC43639.1 - 1.3e-24 86.6 0.1 2.6e-24 85.7 0.1 1.5 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EWC43639.1 - 7.2e-06 25.8 0.0 1.7e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 LisH Ribosomal_L31e PF01198.19 EWC43640.1 - 3.1e-41 139.5 2.3 6.6e-41 138.4 2.3 1.6 1 0 0 1 1 1 1 Ribosomal protein L31e DRMBL PF07522.14 EWC43640.1 - 2.6e-05 24.4 0.0 0.00011 22.3 0.0 2.1 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EWC43640.1 - 3.7e-05 23.3 0.0 8.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EWC43640.1 - 0.0027 17.7 0.0 0.006 16.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Proteasom_Rpn13 PF04683.13 EWC43641.1 - 2.2e-20 73.0 0.0 3.3e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EWC43641.1 - 8.2e-19 67.8 0.0 1.5e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 UCH-binding domain PolyA_pol_arg_C PF12626.7 EWC43642.1 - 0.015 15.4 1.4 0.021 14.8 0.4 1.9 2 1 0 2 2 2 0 Polymerase A arginine-rich C-terminus DUF1656 PF07869.12 EWC43642.1 - 0.1 12.6 0.8 0.19 11.8 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) tRNA-synt_2b PF00587.25 EWC43643.1 - 1.9e-30 106.1 0.0 1.1e-27 97.2 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) XdhC_C PF13478.6 EWC43643.1 - 0.11 13.0 0.1 26 5.3 0.1 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain HLH PF00010.26 EWC43644.1 - 1.9e-07 30.9 0.0 1.9e-07 30.9 0.0 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain FRG2 PF15315.6 EWC43644.1 - 7.7 6.7 8.7 12 6.0 8.7 1.4 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 zf-CCCH PF00642.24 EWC43645.1 - 1.5e-09 37.5 21.2 3e-07 30.2 2.5 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EWC43645.1 - 0.00044 20.0 0.0 0.00071 19.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EWC43645.1 - 0.0058 16.7 3.3 0.0058 16.7 3.3 3.3 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 EWC43645.1 - 0.016 15.9 4.5 0.47 11.2 0.3 2.5 2 0 0 2 2 2 0 Torus domain SCRG1 PF15224.6 EWC43645.1 - 0.11 12.7 4.5 0.2 11.8 0.1 2.5 2 1 0 2 2 2 0 Scrapie-responsive protein 1 zf-CCCH_3 PF15663.5 EWC43645.1 - 0.23 11.7 5.7 0.24 11.6 1.1 2.4 2 0 0 2 2 2 0 Zinc-finger containing family CTNNBL PF08216.11 EWC43646.1 - 1e-40 138.1 0.1 4e-40 136.2 0.0 2.1 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear E3_UbLigase_R4 PF13764.6 EWC43646.1 - 0.0065 14.7 0.1 0.01 14.1 0.1 1.4 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 DUF1664 PF07889.12 EWC43646.1 - 0.18 11.8 1.2 1.9 8.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4944 PF16302.5 EWC43646.1 - 0.64 10.1 2.9 11 6.1 1.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4944) MKRN1_C PF15815.5 EWC43646.1 - 5.9 7.4 11.2 7.1 7.1 0.2 4.3 5 0 0 5 5 5 0 E3 ubiquitin-protein ligase makorin-1, C-terminal Mem_trans PF03547.18 EWC43647.1 - 1.4e-12 46.7 3.8 2.5e-12 45.9 3.8 1.3 1 0 0 1 1 1 1 Membrane transport protein TEA PF01285.18 EWC43648.1 - 6.7e-29 99.8 0.0 1.5e-28 98.7 0.0 1.6 1 0 0 1 1 1 1 TEA/ATTS domain F-box-like PF12937.7 EWC43649.1 - 0.031 14.2 0.5 0.059 13.3 0.5 1.4 1 0 0 1 1 1 0 F-box-like DUF4953 PF16313.5 EWC43650.1 - 0.12 11.6 0.7 0.16 11.2 0.7 1.2 1 0 0 1 1 1 0 Met-zincin DEC-1_N PF04625.13 EWC43650.1 - 8.9 5.2 6.5 1.1 8.2 0.4 2.0 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region F-box-like PF12937.7 EWC43651.1 - 0.0025 17.7 2.6 0.0038 17.1 1.1 2.0 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 EWC43651.1 - 0.11 12.8 0.0 0.59 10.5 0.0 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EWC43651.1 - 0.19 11.7 0.2 0.45 10.5 0.2 1.7 1 0 0 1 1 1 0 F-box domain Metallophos PF00149.28 EWC43654.1 - 4.5e-12 46.9 0.4 6.5e-12 46.4 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EWC43654.1 - 4.2e-05 23.8 0.4 0.0004 20.6 0.4 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF924 PF06041.11 EWC43655.1 - 2.1e-46 158.3 0.0 2.5e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Pkinase PF00069.25 EWC43655.1 - 0.042 13.2 0.4 0.06 12.7 0.4 1.2 1 0 0 1 1 1 0 Protein kinase domain Fungal_trans_2 PF11951.8 EWC43656.1 - 4.3e-05 22.5 3.7 0.00017 20.5 3.6 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Terminase_3C PF17288.2 EWC43657.1 - 0.092 13.1 0.6 0.25 11.7 0.6 1.7 1 0 0 1 1 1 0 Terminase RNAseH like domain Pal1 PF08316.11 EWC43657.1 - 0.6 10.9 5.0 0.26 12.0 0.5 2.6 2 0 0 2 2 2 0 Pal1 cell morphology protein Spt20 PF12090.8 EWC43657.1 - 1.7 8.2 23.6 4.5 6.8 23.6 1.7 1 0 0 1 1 1 0 Spt20 family ubiquitin PF00240.23 EWC43658.1 - 2.5e-21 75.2 0.0 5.8e-21 74.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EWC43658.1 - 1.1e-08 34.8 0.0 2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-C2H2 PF00096.26 EWC43659.1 - 2.5e-08 33.9 14.2 0.0026 18.1 0.2 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EWC43659.1 - 9.1e-06 25.5 3.3 0.096 12.7 0.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EWC43659.1 - 1.8e-05 25.2 11.8 0.022 15.6 0.2 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EWC43659.1 - 0.01 16.1 0.2 0.027 14.7 0.2 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-SNAP50_C PF12251.8 EWC43659.1 - 0.05 13.3 0.3 0.084 12.5 0.3 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal C1_4 PF07975.12 EWC43659.1 - 0.17 12.1 0.1 0.39 11.0 0.1 1.5 1 0 0 1 1 1 0 TFIIH C1-like domain APC_N_CC PF16689.5 EWC43660.1 - 0.034 14.2 0.3 0.086 12.9 0.3 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Peptidase_M41 PF01434.18 EWC43660.1 - 0.09 12.6 0.2 0.09 12.6 0.2 2.5 2 0 0 2 2 2 0 Peptidase family M41 dCache_2 PF08269.11 EWC43660.1 - 0.65 9.1 5.8 9.5 5.3 0.1 2.5 2 0 0 2 2 2 0 Cache domain T3SS_needle_F PF09392.10 EWC43660.1 - 0.7 10.1 4.4 6.9 7.0 0.0 4.1 3 0 0 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF KxDL PF10241.9 EWC43660.1 - 2.7 8.3 11.3 2.5 8.4 1.8 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein RmuC PF02646.16 EWC43661.1 - 0.012 14.8 3.2 0.17 11.0 0.1 2.5 1 1 0 2 2 2 0 RmuC family DUF3912 PF13051.6 EWC43661.1 - 0.053 13.8 0.1 14 6.0 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3912) DUF1611_N PF17396.2 EWC43661.1 - 0.057 13.6 1.3 0.17 12.2 1.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1611_N) Rossmann-like domain AAA_27 PF13514.6 EWC43661.1 - 0.084 12.5 3.9 0.036 13.7 1.5 1.5 2 0 0 2 2 2 0 AAA domain BLOC1_2 PF10046.9 EWC43661.1 - 0.21 11.9 3.3 5 7.5 0.3 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cob_adeno_trans PF01923.18 EWC43661.1 - 0.27 11.4 4.2 0.19 11.9 1.0 1.9 1 1 1 2 2 2 0 Cobalamin adenosyltransferase APG6_N PF17675.1 EWC43661.1 - 0.74 10.4 7.5 0.079 13.5 0.4 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region GCN5L1 PF06320.13 EWC43661.1 - 1.4 9.1 8.1 7.9 6.7 4.6 2.4 2 1 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) HWE_HK PF07536.14 EWC43662.1 - 0.019 15.7 2.5 0.028 15.1 2.5 1.3 1 0 0 1 1 1 0 HWE histidine kinase Pkinase PF00069.25 EWC43664.1 - 1.8e-73 247.2 0.0 2.6e-73 246.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43664.1 - 2.6e-36 125.3 0.0 5.3e-36 124.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC43664.1 - 0.00082 19.4 0.6 0.013 15.5 0.1 2.7 1 1 2 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EWC43664.1 - 0.0013 18.1 0.4 1.4 8.2 0.0 2.5 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EWC43664.1 - 0.015 14.1 0.0 0.032 13.0 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase SpoIID PF08486.10 EWC43666.1 - 0.22 12.1 0.0 0.64 10.6 0.0 1.7 2 0 0 2 2 2 0 Stage II sporulation protein Tom22 PF04281.13 EWC43667.1 - 0.016 15.0 1.8 0.029 14.2 1.8 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 ANTH PF07651.16 EWC43667.1 - 0.11 11.4 0.0 0.26 10.2 0.0 1.6 1 0 0 1 1 1 0 ANTH domain Cwf_Cwc_15 PF04889.12 EWC43667.1 - 0.14 11.9 8.2 0.23 11.2 8.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 EWC43667.1 - 0.16 11.6 1.3 2.1 8.0 1.0 2.3 2 0 0 2 2 2 0 FAM176 family NOA36 PF06524.12 EWC43667.1 - 2.6 7.3 8.5 4.8 6.4 8.5 1.4 1 0 0 1 1 1 0 NOA36 protein Aldo_ket_red PF00248.21 EWC43670.1 - 5.5e-45 153.8 0.0 6.3e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GST_C_3 PF14497.6 EWC43673.1 - 8.9e-21 73.9 0.0 2.2e-20 72.7 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EWC43673.1 - 0.014 15.4 2.2 0.036 14.1 2.1 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EWC43673.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MAPEG PF01124.18 EWC43674.1 - 4.5e-21 75.1 2.3 5.6e-21 74.8 2.3 1.1 1 0 0 1 1 1 1 MAPEG family OPT PF03169.15 EWC43675.1 - 5e-94 316.1 37.0 5.8e-94 315.9 37.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Cellulase PF00150.18 EWC43676.1 - 3.1e-10 40.0 0.0 3.1e-10 40.0 0.0 1.7 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) MRI PF15325.6 EWC43676.1 - 0.13 13.4 4.1 0.29 12.2 4.1 1.5 1 0 0 1 1 1 0 Modulator of retrovirus infection Pneumo_att_G PF05539.11 EWC43676.1 - 1 8.9 9.2 1.5 8.3 9.2 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SKG6 PF08693.10 EWC43676.1 - 1.6 8.2 10.0 3.1 7.3 10.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain F-box-like PF12937.7 EWC43678.1 - 0.0087 15.9 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EWC43678.1 - 0.21 11.9 0.0 0.43 10.9 0.0 1.5 1 0 0 1 1 1 0 PRANC domain Glyco_hydro_43 PF04616.14 EWC43679.1 - 4.1e-27 95.2 2.7 3.6e-26 92.2 2.7 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 F-box-like PF12937.7 EWC43680.1 - 0.017 15.0 0.1 0.076 12.9 0.0 2.1 2 0 0 2 2 2 0 F-box-like SAP130_C PF16014.5 EWC43681.1 - 2.8 6.9 14.3 3.6 6.6 14.3 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Acyl-CoA_dh_1 PF00441.24 EWC43682.1 - 1.2e-27 97.0 0.0 1.6e-27 96.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EWC43682.1 - 5.4e-25 87.4 0.1 1e-24 86.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EWC43682.1 - 1.4e-22 80.5 0.0 4e-22 79.0 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EWC43682.1 - 2.6e-05 24.5 0.0 4.1e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acetyltransf_1 PF00583.25 EWC43685.1 - 1.1e-09 38.5 0.0 2.5e-09 37.4 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC43685.1 - 4.1e-09 36.4 0.0 2.4e-07 30.7 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC43685.1 - 3.7e-08 33.7 0.0 3.3e-07 30.7 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EWC43685.1 - 0.17 11.9 0.0 0.41 10.7 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein Amidohydro_3 PF07969.11 EWC43686.1 - 8.2e-50 170.6 1.4 1.1e-49 170.2 1.4 1.1 1 0 0 1 1 1 1 Amidohydrolase family F-box-like PF12937.7 EWC43688.1 - 1.4e-05 24.9 0.5 4e-05 23.4 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC43688.1 - 2.6e-05 23.9 0.1 5.1e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 F-box domain Tannase PF07519.11 EWC43689.1 - 4.2e-75 253.5 0.5 5.3e-75 253.1 0.5 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EWC43689.1 - 0.00011 21.5 0.0 0.009 15.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EWC43689.1 - 0.00032 20.4 0.3 0.037 13.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EWC43689.1 - 0.00057 19.4 2.0 0.17 11.3 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family F-box-like PF12937.7 EWC43690.1 - 3.5e-08 33.2 1.3 0.00028 20.7 0.0 2.3 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 EWC43690.1 - 7.1e-06 25.8 0.1 0.019 14.9 0.0 2.7 1 1 1 2 2 2 2 F-box domain Nop53 PF07767.11 EWC43690.1 - 1 8.7 6.1 1.3 8.3 6.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) MR_MLE_C PF13378.6 EWC43691.1 - 4.3e-39 134.4 0.0 5.7e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EWC43691.1 - 3.7e-10 40.0 0.0 7.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DHDPS PF00701.22 EWC43692.1 - 1e-29 103.2 0.1 1.3e-29 102.9 0.1 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family CbiD PF01888.17 EWC43692.1 - 0.045 13.0 0.1 0.074 12.3 0.1 1.3 1 0 0 1 1 1 0 CbiD Glyco_trans_4_5 PF16994.5 EWC43692.1 - 0.15 11.7 0.1 0.28 10.8 0.1 1.4 1 0 0 1 1 1 0 Glycosyl-transferase family 4 DUF4470 PF14737.6 EWC43694.1 - 0.00075 19.6 0.1 0.0015 18.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Voltage_CLC PF00654.20 EWC43695.1 - 0.0041 16.4 0.3 0.0048 16.2 0.3 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel Glyco_hydro_15 PF00723.21 EWC43696.1 - 3.6e-67 227.1 0.0 4.4e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 TAD2 PF18521.1 EWC43697.1 - 0.12 12.4 0.6 5.6 7.1 0.0 2.7 2 0 0 2 2 2 0 Transactivation domain 2 G-alpha PF00503.20 EWC43699.1 - 1.1e-110 370.1 0.9 1.3e-110 369.9 0.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EWC43699.1 - 9e-14 51.3 1.7 5.2e-09 35.8 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EWC43699.1 - 5.3e-06 26.0 2.4 0.009 15.4 0.0 3.1 3 0 0 3 3 3 2 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.18 EWC43699.1 - 0.0031 16.9 0.0 0.0058 16.0 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family Roc PF08477.13 EWC43699.1 - 0.0062 16.8 0.1 2.1 8.6 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EWC43699.1 - 0.055 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 EWC43699.1 - 0.079 12.5 0.0 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF2231 PF09990.9 EWC43699.1 - 0.17 12.3 0.0 0.29 11.6 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) DUF676 PF05057.14 EWC43700.1 - 2.6e-53 180.8 0.0 3.7e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EWC43700.1 - 2.9e-06 27.3 0.0 4.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 EWC43700.1 - 1.1e-05 26.2 0.1 2e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EWC43700.1 - 0.0001 22.1 0.0 0.00033 20.4 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EWC43700.1 - 0.043 13.7 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Homeodomain PF00046.29 EWC43701.1 - 5e-15 55.1 4.7 2.1e-14 53.1 4.8 2.1 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EWC43701.1 - 0.029 14.3 0.6 0.085 12.8 0.6 1.8 1 0 0 1 1 1 0 Homeobox KN domain Methyltransf_34 PF11312.8 EWC43702.1 - 2.7e-54 184.5 0.0 4.1e-54 183.9 0.0 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Amino_oxidase PF01593.24 EWC43703.1 - 6.4e-51 174.0 0.1 9.2e-50 170.2 0.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EWC43703.1 - 5.2e-13 49.0 0.1 1.2e-12 47.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EWC43703.1 - 7.1e-07 28.7 0.2 7.6e-06 25.4 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EWC43703.1 - 3.7e-05 22.6 0.3 6.9e-05 21.7 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EWC43703.1 - 8.7e-05 21.9 0.6 0.00014 21.2 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EWC43703.1 - 0.00018 21.3 1.4 0.00077 19.1 1.3 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EWC43703.1 - 0.00018 22.0 0.6 0.0004 20.9 0.6 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EWC43703.1 - 0.00023 20.5 0.1 0.00042 19.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 EWC43703.1 - 0.00063 19.1 0.3 0.001 18.4 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EWC43703.1 - 0.00074 18.7 1.7 0.0012 18.1 1.7 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EWC43703.1 - 0.00084 18.8 0.1 0.0013 18.2 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EWC43703.1 - 0.0012 19.2 0.0 0.0022 18.4 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 EWC43703.1 - 0.003 16.9 1.0 0.0061 15.9 0.6 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EWC43703.1 - 0.0033 16.5 0.3 1.6 7.7 0.4 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Shikimate_DH PF01488.20 EWC43703.1 - 0.0089 16.1 0.1 0.016 15.3 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EWC43703.1 - 0.016 14.6 0.1 0.026 13.9 0.1 1.3 1 0 0 1 1 1 0 ThiF family 3HCDH_N PF02737.18 EWC43703.1 - 0.021 14.7 0.4 0.034 14.0 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EWC43703.1 - 0.053 12.6 1.1 0.072 12.2 0.3 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 EWC43703.1 - 0.095 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EWC43703.1 - 0.12 12.3 0.4 1.7 8.6 0.2 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding Band_7 PF01145.25 EWC43704.1 - 8.6e-24 84.5 5.6 2e-23 83.3 5.6 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EWC43704.1 - 0.00039 19.6 2.9 0.0005 19.2 2.9 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial GatB_Yqey PF02637.18 EWC43704.1 - 0.0022 17.9 2.0 0.0037 17.2 2.0 1.4 1 0 0 1 1 1 1 GatB domain UcrQ PF02939.16 EWC43705.1 - 2.7e-34 117.0 0.2 3e-34 116.8 0.2 1.0 1 0 0 1 1 1 1 UcrQ family Ribosomal_L7Ae PF01248.26 EWC43708.1 - 9.6e-26 89.4 0.0 1.2e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EWC43708.1 - 0.00017 21.7 0.1 0.00019 21.5 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 EWC43708.1 - 0.00054 19.8 0.0 0.00071 19.4 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain ATP-synt_C PF00137.21 EWC43709.1 - 1.3e-33 115.1 32.5 2.9e-22 78.8 14.4 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Tetraspanin PF00335.20 EWC43709.1 - 2.9 7.5 7.2 5.1 6.7 7.2 1.3 1 0 0 1 1 1 0 Tetraspanin family Sugar_tr PF00083.24 EWC43710.1 - 4e-81 273.2 15.7 4.9e-81 272.9 15.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC43710.1 - 5.2e-09 35.5 42.1 2.7e-06 26.5 19.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily UAA PF08449.11 EWC43710.1 - 0.0014 17.9 0.2 0.0032 16.7 0.2 1.5 2 0 0 2 2 2 1 UAA transporter family DUF2574 PF10836.8 EWC43710.1 - 0.26 11.2 0.4 0.71 9.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2574) DUF4530 PF15039.6 EWC43711.1 - 0.73 10.0 5.6 1.4 9.1 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Mito_carr PF00153.27 EWC43715.1 - 1.9e-49 165.5 0.1 3e-18 65.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4907 PF16250.5 EWC43716.1 - 0.024 14.5 0.0 0.063 13.2 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4907) CHORD PF04968.12 EWC43716.1 - 0.076 13.7 2.6 0.15 12.8 2.6 1.4 1 0 0 1 1 1 0 CHORD RNase_T PF00929.24 EWC43716.1 - 0.083 13.4 0.0 12 6.4 0.0 2.9 3 0 0 3 3 3 0 Exonuclease BTK PF00779.19 EWC43716.1 - 0.19 11.6 5.2 0.37 10.6 5.2 1.5 1 0 0 1 1 1 0 BTK motif Golgin_A5 PF09787.9 EWC43717.1 - 0.0067 15.9 3.5 0.011 15.2 3.5 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 HMMR_N PF15905.5 EWC43717.1 - 0.011 15.3 4.1 0.015 14.8 4.1 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Csm1_N PF18504.1 EWC43717.1 - 0.093 13.1 6.4 2.8 8.3 0.7 2.6 1 1 1 2 2 2 0 Csm1 N-terminal domain DUF641 PF04859.12 EWC43717.1 - 0.14 12.4 5.9 2.9 8.2 5.9 2.4 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Rx_N PF18052.1 EWC43717.1 - 0.22 11.8 5.2 0.71 10.2 3.7 2.6 1 1 1 2 2 2 0 Rx N-terminal domain Cwf_Cwc_15 PF04889.12 EWC43718.1 - 0.13 12.0 2.8 0.15 11.8 2.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Cupin_8 PF13621.6 EWC43722.1 - 9.2e-17 61.6 0.0 1.2e-16 61.2 0.0 1.4 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EWC43722.1 - 0.023 15.1 0.0 0.11 12.9 0.0 1.9 2 0 0 2 2 2 0 JmjC domain, hydroxylase Cupin_4 PF08007.12 EWC43722.1 - 0.066 12.7 0.0 0.3 10.5 0.0 1.9 2 0 0 2 2 2 0 Cupin superfamily protein Cupin_1 PF00190.22 EWC43722.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Cupin Peptidase_S8 PF00082.22 EWC43724.1 - 2.8e-39 135.2 16.7 4e-39 134.7 16.7 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EWC43724.1 - 2.2e-13 50.7 0.3 6.8e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Peptidase inhibitor I9 DUF1127 PF06568.11 EWC43725.1 - 0.23 11.2 0.3 0.39 10.5 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) Glyco_hydro_61 PF03443.14 EWC43726.1 - 7.6e-59 199.1 0.0 8.8e-59 198.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Peptidase_S41 PF03572.18 EWC43727.1 - 1.1e-07 31.6 0.0 7.5e-07 28.9 0.0 2.0 1 1 0 1 1 1 1 Peptidase family S41 Y_phosphatase3 PF13350.6 EWC43728.1 - 4.7e-34 118.4 0.0 7.7e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EWC43728.1 - 5.7e-06 26.0 0.0 1.2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family MapZ_EC1 PF18041.1 EWC43728.1 - 0.079 13.2 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 MapZ extracellular domain 1 Y_phosphatase PF00102.27 EWC43728.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ABC_membrane PF00664.23 EWC43729.1 - 6.1e-57 193.4 37.7 6.7e-34 117.8 17.8 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EWC43729.1 - 1.2e-51 174.9 0.1 3.1e-29 102.2 0.1 2.8 2 0 0 2 2 2 2 ABC transporter MMR_HSR1 PF01926.23 EWC43729.1 - 1.4e-07 31.6 3.8 0.0088 16.1 0.1 3.8 3 0 0 3 3 3 2 50S ribosome-binding GTPase SMC_N PF02463.19 EWC43729.1 - 6.1e-07 29.1 2.9 0.046 13.1 0.0 3.5 2 1 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EWC43729.1 - 3.6e-05 24.2 0.7 0.16 12.3 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EWC43729.1 - 5.1e-05 23.2 1.7 0.27 11.1 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EWC43729.1 - 9.9e-05 22.5 1.3 0.081 13.0 0.5 2.6 2 0 0 2 2 2 2 Dynamin family AAA_22 PF13401.6 EWC43729.1 - 0.00011 22.5 1.6 0.2 11.9 0.2 3.2 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EWC43729.1 - 0.00011 21.9 1.0 0.22 11.3 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EWC43729.1 - 0.0003 21.0 2.1 0.11 12.5 0.3 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_15 PF13175.6 EWC43729.1 - 0.00035 20.4 0.0 0.39 10.4 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EWC43729.1 - 0.00081 19.9 0.3 0.96 9.9 0.1 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EWC43729.1 - 0.0028 17.0 0.0 0.23 10.7 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Roc PF08477.13 EWC43729.1 - 0.0058 16.8 0.5 2.9 8.1 0.1 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 EWC43729.1 - 0.0069 16.2 6.2 2.8 7.6 0.3 4.3 3 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 EWC43729.1 - 0.0094 15.5 0.4 1.1 8.8 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EWC43729.1 - 0.014 15.8 0.1 3.7 8.0 0.0 3.2 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 EWC43729.1 - 0.026 14.2 1.2 5.6 6.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EWC43729.1 - 0.057 12.8 0.4 5.9 6.2 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.17 EWC43729.1 - 0.12 12.1 0.4 7.2 6.3 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein CDC45 PF02724.14 EWC43729.1 - 0.12 10.6 0.4 0.22 9.8 0.4 1.3 1 0 0 1 1 1 0 CDC45-like protein Ploopntkinase3 PF18751.1 EWC43729.1 - 0.15 11.9 0.3 9.4 6.1 0.1 2.6 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 LZ3wCH PF18517.1 EWC43730.1 - 2.2e-06 27.7 0.5 1.2e-05 25.3 0.1 2.3 2 1 0 2 2 2 1 Leucine zipper with capping helix domain Arrestin_N PF00339.29 EWC43731.1 - 2.4e-11 43.9 0.0 7.9e-11 42.2 0.0 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EWC43731.1 - 9.7e-05 22.8 0.2 0.015 15.7 0.1 2.7 2 2 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Mucin-like PF16058.5 EWC43733.1 - 0.0016 18.5 33.9 0.25 11.5 1.1 7.4 2 2 4 6 6 6 5 Mucin-like TraV PF09676.10 EWC43733.1 - 0.14 13.1 24.8 1.4e+02 3.4 0.2 9.3 2 2 2 6 6 6 0 Type IV conjugative transfer system lipoprotein (TraV) PhetRS_B1 PF18262.1 EWC43734.1 - 0.12 12.6 0.0 4.4 7.6 0.0 2.3 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain SPX PF03105.19 EWC43734.1 - 0.38 10.6 7.9 0.4 10.5 7.9 1.1 1 0 0 1 1 1 0 SPX domain Apc15p PF05841.11 EWC43734.1 - 3.4 8.5 8.1 0.36 11.6 0.7 2.4 1 1 2 3 3 3 0 Apc15p protein Fungal_trans PF04082.18 EWC43735.1 - 1.9e-18 66.5 3.4 1.1e-17 64.0 3.4 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF2605 PF10792.9 EWC43736.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Glyco_hydro_1 PF00232.18 EWC43738.1 - 0.079 11.4 0.0 0.095 11.1 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 BNR PF02012.20 EWC43739.1 - 0.0017 18.1 3.5 0.97 9.7 0.1 3.5 3 0 0 3 3 3 2 BNR/Asp-box repeat BNR_2 PF13088.6 EWC43739.1 - 0.018 14.3 0.2 0.2 11.0 0.3 2.2 1 1 1 2 2 2 0 BNR repeat-like domain zf-CCCH PF00642.24 EWC43741.1 - 5.4e-05 23.0 1.7 0.00014 21.7 1.7 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EWC43741.1 - 0.00012 22.7 0.1 0.00029 21.5 0.1 1.5 1 0 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 EWC43741.1 - 0.0006 19.5 1.8 0.0016 18.2 1.8 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EWC43741.1 - 0.011 16.2 3.2 0.03 14.8 3.2 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 EWC43741.1 - 0.046 13.8 5.7 0.12 12.5 5.7 1.7 1 0 0 1 1 1 0 Zinc finger domain Herpes_BLLF1 PF05109.13 EWC43744.1 - 0.31 9.0 5.1 0.78 7.6 0.1 2.0 2 0 0 2 2 2 0 Herpes virus major outer envelope glycoprotein (BLLF1) zf-C3HC4_3 PF13920.6 EWC43745.1 - 6.3e-11 42.0 3.5 1.3e-10 41.0 3.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EWC43745.1 - 4.8e-07 29.5 3.3 2e-06 27.5 3.3 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EWC43745.1 - 2.8e-05 24.0 1.8 4.6e-05 23.3 1.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EWC43745.1 - 0.00033 20.9 3.2 0.00066 19.9 3.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EWC43745.1 - 0.0019 18.1 1.8 0.0038 17.1 1.3 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EWC43745.1 - 0.12 12.2 8.0 0.16 11.9 2.1 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) NUDIX PF00293.28 EWC43748.1 - 1.2e-05 25.4 0.0 4.1e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 NUDIX domain Ribonuclease_T2 PF00445.18 EWC43749.1 - 5.1e-39 134.4 3.5 5.1e-39 134.4 3.5 1.6 2 0 0 2 2 2 1 Ribonuclease T2 family EamA PF00892.20 EWC43751.1 - 2.9e-09 37.2 32.0 8.4e-07 29.2 1.8 2.6 3 0 0 3 3 3 2 EamA-like transporter family DUF4179 PF13786.6 EWC43751.1 - 0.1 13.1 4.1 4.5 7.8 0.3 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) DMT_6 PF04342.12 EWC43751.1 - 6.3 7.1 9.5 1.3 9.2 1.2 3.1 3 0 0 3 3 3 0 Putative member of DMT superfamily (DUF486) HATPase_c PF02518.26 EWC43752.1 - 1.1e-26 93.5 0.0 8.1e-25 87.5 0.0 2.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EWC43752.1 - 1.2e-26 93.0 1.2 2.3e-26 92.2 1.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EWC43752.1 - 2e-13 50.1 0.0 5.6e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Zn_clus PF00172.18 EWC43752.1 - 8.7e-08 32.2 8.8 1.5e-07 31.4 8.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EWC43752.1 - 0.0002 20.5 0.0 0.00032 19.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HAMP PF00672.25 EWC43752.1 - 0.00034 20.9 0.0 0.25 11.8 0.0 3.1 3 0 0 3 3 3 2 HAMP domain Fungal_trans PF04082.18 EWC43753.1 - 7e-15 54.8 0.0 1.1e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC43753.1 - 5.5e-09 36.0 7.1 1e-08 35.2 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2439 PF10382.9 EWC43756.1 - 3.2e-23 81.9 0.6 5.2e-23 81.2 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) MFS_1 PF07690.16 EWC43757.1 - 1.9e-44 152.0 50.0 4.3e-44 150.9 50.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EWC43757.1 - 2.8e-13 49.2 19.6 3.6e-13 48.8 19.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EWC43757.1 - 5.3e-06 25.6 14.3 5.3e-06 25.6 14.3 3.6 3 2 1 4 4 4 2 Sugar (and other) transporter TauD PF02668.16 EWC43759.1 - 8.5e-25 88.1 0.0 1.2e-24 87.5 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EWC43759.1 - 0.068 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 CsiD ETF PF01012.21 EWC43760.1 - 4.3e-41 140.8 0.4 5.3e-41 140.5 0.4 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain AbiEi_1 PF09407.10 EWC43760.1 - 0.045 14.1 0.1 0.091 13.1 0.1 1.4 1 0 0 1 1 1 0 AbiEi antitoxin C-terminal domain EF-hand_1 PF00036.32 EWC43761.1 - 7e-35 116.0 15.9 2.7e-10 39.0 1.7 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EWC43761.1 - 2.7e-30 104.6 11.3 2.6e-16 59.8 2.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EWC43761.1 - 6.6e-29 97.3 13.4 2.8e-09 36.1 0.2 4.6 4 1 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 EWC43761.1 - 7.4e-22 77.0 15.4 2.1e-12 46.7 1.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EWC43761.1 - 5.4e-18 65.1 1.0 1.2e-08 35.1 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EWC43761.1 - 1e-17 62.7 19.2 3.1e-06 26.4 0.9 4.8 5 1 1 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.9 EWC43761.1 - 5.5e-07 29.9 2.3 0.0033 17.7 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EWC43761.1 - 8.5e-07 28.9 4.8 0.0066 16.4 0.7 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 EWC43761.1 - 5.3e-05 23.2 0.0 0.34 11.0 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) TerB PF05099.13 EWC43761.1 - 0.00047 20.1 3.4 0.73 9.8 0.1 3.0 1 1 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_14 PF17959.1 EWC43761.1 - 0.003 17.8 1.1 1.5 9.2 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain DUF2267 PF10025.9 EWC43761.1 - 0.0043 17.3 0.4 0.0081 16.4 0.3 1.5 2 0 0 2 2 1 1 Uncharacterized conserved protein (DUF2267) SapB_1 PF05184.15 EWC43761.1 - 0.0053 16.8 0.0 4.1 7.5 0.0 2.5 2 0 0 2 2 2 1 Saposin-like type B, region 1 SurA_N_2 PF13623.6 EWC43761.1 - 0.01 15.7 0.7 0.4 10.5 0.2 2.5 1 1 2 3 3 3 0 SurA N-terminal domain EF-hand_11 PF08976.11 EWC43761.1 - 0.015 16.1 1.0 1.4 9.8 0.1 2.1 1 1 1 2 2 2 0 EF-hand domain Caleosin PF05042.13 EWC43761.1 - 0.021 14.7 1.4 7.6 6.4 0.0 2.9 1 1 3 4 4 4 0 Caleosin related protein DUF3349 PF11829.8 EWC43761.1 - 0.03 15.1 1.0 5.1 7.9 0.0 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF3349) ApbA_C PF08546.11 EWC43761.1 - 0.067 13.4 0.1 4.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal UBA_6 PF18039.1 EWC43761.1 - 0.077 12.9 0.0 5.2 7.1 0.0 2.3 2 0 0 2 2 2 0 UBA-like domain DUF1456 PF07308.13 EWC43761.1 - 0.088 13.2 0.7 5.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) DUF4539 PF15072.6 EWC43761.1 - 0.091 12.8 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) SurA_N_3 PF13624.6 EWC43761.1 - 0.094 12.5 0.4 0.52 10.1 0.2 2.0 1 1 1 2 2 2 0 SurA N-terminal domain HTH_40 PF14493.6 EWC43761.1 - 0.11 13.0 0.1 0.83 10.1 0.1 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain HGD-D PF06050.13 EWC43761.1 - 0.13 12.0 0.8 0.48 10.1 0.6 1.8 1 1 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component DUF1801 PF08818.11 EWC43761.1 - 0.14 12.7 0.1 1.6 9.3 0.0 2.5 2 1 0 2 2 1 0 Domain of unknown function (DU1801) Glycos_trans_3N PF02885.17 EWC43761.1 - 0.15 11.9 3.6 29 4.6 0.0 4.3 3 2 1 4 4 4 0 Glycosyl transferase family, helical bundle domain RNA_pol_Rpb4 PF03874.16 EWC43761.1 - 0.19 12.1 2.4 10 6.5 0.2 2.6 1 1 1 2 2 2 0 RNA polymerase Rpb4 VbhA PF18495.1 EWC43761.1 - 0.25 11.3 1.1 85 3.1 0.1 3.8 4 0 0 4 4 4 0 Antitoxin VbhA Fer2_BFD PF04324.15 EWC43761.1 - 0.28 11.5 0.4 4.3 7.8 0.1 2.7 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain EF-hand_10 PF14788.6 EWC43761.1 - 0.37 10.7 6.6 0.48 10.3 0.1 3.6 2 2 1 4 4 4 0 EF hand T4_Rnl2_C PF18043.1 EWC43761.1 - 0.39 10.9 4.7 0.34 11.1 0.5 2.8 1 1 1 2 2 2 0 T4 RNA ligase 2 C-terminal SAP PF02037.27 EWC43762.1 - 1.1e-11 44.2 2.4 1.8e-11 43.5 2.4 1.4 1 0 0 1 1 1 1 SAP domain RSB_motif PF16294.5 EWC43762.1 - 1.1e-06 28.8 0.0 1.1e-06 28.8 0.0 5.7 4 2 1 5 5 5 1 RNSP1-SAP18 binding (RSB) motif Pinin_SDK_memA PF04696.13 EWC43762.1 - 0.048 13.7 0.1 0.048 13.7 0.1 3.7 4 1 1 5 5 5 0 pinin/SDK/memA/ protein conserved region Apolipoprotein PF01442.18 EWC43763.1 - 0.0018 18.2 4.7 0.0091 15.9 4.7 1.8 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain GARP PF16731.5 EWC43763.1 - 0.097 12.4 12.1 0.13 12.0 12.1 1.2 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF1664 PF07889.12 EWC43763.1 - 0.1 12.6 1.8 0.16 12.0 1.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) ISG65-75 PF11727.8 EWC43763.1 - 0.12 11.6 11.8 0.15 11.3 11.8 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein SKA1 PF07160.12 EWC43763.1 - 0.13 12.0 3.1 0.16 11.8 3.1 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 YtxH PF12732.7 EWC43763.1 - 0.28 11.8 14.6 1.2e+02 3.3 14.6 2.4 1 1 0 1 1 1 0 YtxH-like protein SH3BP5 PF05276.14 EWC43763.1 - 0.3 10.9 6.2 0.41 10.4 6.0 1.3 1 1 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) CsbD PF05532.12 EWC43763.1 - 0.34 10.9 17.3 0.19 11.7 1.1 4.3 2 2 2 4 4 4 0 CsbD-like DDHD PF02862.17 EWC43763.1 - 0.92 9.6 3.8 1.1 9.4 3.8 1.1 1 0 0 1 1 1 0 DDHD domain Phage_holin_6_1 PF09682.10 EWC43763.1 - 1.1 9.8 8.2 1.2 9.6 6.9 1.8 1 1 1 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) DUF948 PF06103.11 EWC43763.1 - 2 8.7 6.2 9.2 6.6 6.2 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) HSP9_HSP12 PF04119.12 EWC43763.1 - 3.5 8.1 8.5 3.4 8.1 0.4 3.3 1 1 2 3 3 3 0 Heat shock protein 9/12 GATase PF00117.28 EWC43765.1 - 1.3e-44 152.3 0.0 1.8e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EWC43765.1 - 3.3e-44 149.8 0.0 6.3e-44 148.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 EWC43765.1 - 0.00069 19.4 0.4 0.065 13.0 0.4 2.3 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 EWC43765.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.2 1 0 0 1 1 1 0 DJ-1/PfpI family Nitroreductase PF00881.24 EWC43766.1 - 4.2e-16 59.5 0.0 4.9e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Epimerase PF01370.21 EWC43767.1 - 3.4e-33 115.1 0.0 1e-32 113.5 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EWC43767.1 - 5.9e-28 98.2 0.0 2.9e-26 92.7 0.0 2.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EWC43767.1 - 4.5e-08 32.6 0.0 1.1e-07 31.4 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EWC43767.1 - 3.6e-07 29.5 0.0 9.2e-07 28.1 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EWC43767.1 - 8e-06 25.2 0.0 2.4e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EWC43767.1 - 0.023 14.2 0.0 0.6 9.5 0.0 2.7 2 1 0 2 2 2 0 short chain dehydrogenase IF2_N PF04760.15 EWC43767.1 - 0.083 12.7 0.0 0.27 11.1 0.0 1.9 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region RgpF PF05045.12 EWC43768.1 - 0.014 14.2 0.0 0.036 12.9 0.0 1.6 2 0 0 2 2 2 0 Rhamnan synthesis protein F SARAF PF06682.12 EWC43769.1 - 0.0071 16.0 0.3 0.017 14.8 0.1 1.9 1 1 1 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis Fig1 PF12351.8 EWC43769.1 - 0.18 11.7 3.7 6.8 6.6 1.8 2.2 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Ammonium_transp PF00909.21 EWC43770.1 - 2.2e-110 369.1 27.5 2.5e-110 368.9 27.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family BTB PF00651.31 EWC43774.1 - 2.7e-09 37.2 0.0 1.6e-06 28.3 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain DUF4535 PF15054.6 EWC43774.1 - 0.032 14.0 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) zf-CSL PF05207.13 EWC43774.1 - 0.36 10.6 3.5 4 7.2 1.1 2.5 2 0 0 2 2 2 0 CSL zinc finger MFS_1 PF07690.16 EWC43776.1 - 2.3e-28 99.2 83.5 6.3e-25 87.8 51.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC43776.1 - 0.00021 20.3 40.0 0.079 11.8 13.3 3.6 1 1 2 3 3 3 3 Sugar (and other) transporter FAD_binding_4 PF01565.23 EWC43778.1 - 4.1e-25 88.1 1.2 7.4e-25 87.3 1.2 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EWC43778.1 - 3e-13 49.6 0.6 5.7e-13 48.7 0.6 1.5 1 0 0 1 1 1 1 Berberine and berberine like Acid_PPase PF12689.7 EWC43778.1 - 0.18 11.6 0.0 0.68 9.8 0.0 1.8 2 0 0 2 2 2 0 Acid Phosphatase WSC PF01822.19 EWC43779.1 - 1.3e-32 111.8 25.2 1.4e-18 66.8 8.3 5.6 6 0 0 6 6 6 2 WSC domain GRDP-like PF07173.12 EWC43780.1 - 1.7e-20 74.1 0.3 5.8e-17 62.7 0.1 2.5 2 0 0 2 2 2 2 Glycine-rich domain-containing protein-like DUF2183 PF09949.9 EWC43781.1 - 3.4e-29 101.1 0.0 6.4e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) NiFe_hyd_3_EhaA PF17367.2 EWC43782.1 - 2.2 8.5 7.2 0.62 10.2 3.6 2.0 1 1 1 2 2 2 0 NiFe-hydrogenase-type-3 Eha complex subunit A C2 PF00168.30 EWC43783.1 - 1.9e-05 24.9 0.0 5.1e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 C2 domain 4HBT_3 PF13622.6 EWC43784.1 - 1.1e-46 160.2 0.0 1.2e-46 160.0 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily TauD PF02668.16 EWC43785.1 - 6.8e-05 22.8 0.0 0.004 17.0 0.0 2.4 2 0 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family Metallophos PF00149.28 EWC43786.1 - 5.9e-15 56.3 0.2 7e-15 56.1 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase HTH_38 PF13936.6 EWC43787.1 - 0.31 10.8 2.7 4.3 7.2 0.2 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Ferritin PF00210.24 EWC43788.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Ferritin-like domain polyprenyl_synt PF00348.17 EWC43790.1 - 5.1e-93 310.8 0.1 6.3e-93 310.5 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 EWC43790.1 - 0.093 12.1 0.0 0.26 10.6 0.0 1.7 1 1 0 1 1 1 0 Terpene synthase family, metal binding domain Cnd3 PF12719.7 EWC43791.1 - 2.2e-97 325.8 1.0 4.1e-97 324.9 1.0 1.5 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 EWC43791.1 - 0.0016 18.6 3.4 41 4.8 0.0 6.0 6 0 0 6 6 6 2 HEAT repeat GATase_5 PF13507.6 EWC43792.1 - 6.9e-101 336.7 0.0 9.9e-101 336.2 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EWC43792.1 - 2.7e-40 138.1 0.6 4.5e-26 91.8 0.4 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EWC43792.1 - 1.3e-28 99.3 0.0 2.6e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EWC43792.1 - 2.7e-18 66.2 0.0 8.6e-18 64.6 0.0 1.9 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 EWC43792.1 - 0.036 14.7 0.1 0.87 10.3 0.0 2.6 2 0 0 2 2 2 0 AIR synthase related protein, N-terminal domain Tegument_dsDNA PF12818.7 EWC43792.1 - 0.14 11.3 0.0 0.5 9.5 0.0 1.8 2 0 0 2 2 2 0 dsDNA viral tegument protein PALP PF00291.25 EWC43793.1 - 5.9e-67 226.2 0.1 7.2e-67 225.9 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Telomere_Sde2_2 PF13297.6 EWC43793.1 - 0.1 12.3 0.2 26 4.5 0.0 3.3 3 0 0 3 3 3 0 Telomere stability C-terminal SLATT_fungal PF18142.1 EWC43794.1 - 0.0052 16.8 0.7 0.0052 16.8 0.7 2.0 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain RRM_1 PF00076.22 EWC43795.1 - 2.9e-17 62.3 0.0 1.8e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EWC43795.1 - 0.11 12.6 0.0 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 RNA binding motif GalKase_gal_bdg PF10509.9 EWC43796.1 - 4.4e-19 67.8 0.0 9.6e-19 66.7 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EWC43796.1 - 7e-17 61.4 1.7 1.5e-16 60.3 1.7 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EWC43796.1 - 1.4e-15 57.4 0.0 3.4e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal TPP_enzyme_N PF02776.18 EWC43797.1 - 2.3e-54 183.6 0.1 2.9e-53 180.0 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EWC43797.1 - 1.9e-50 170.6 0.6 1.8e-48 164.2 0.1 3.1 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EWC43797.1 - 8e-43 145.5 0.5 2.1e-42 144.1 0.2 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain GAD PF02938.14 EWC43797.1 - 0.097 12.9 0.0 25 5.2 0.0 3.1 2 1 1 3 3 3 0 GAD domain ATP_sub_h PF10775.9 EWC43798.1 - 1e-27 95.9 0.5 1.8e-27 95.1 0.5 1.4 1 0 0 1 1 1 1 ATP synthase complex subunit h TFIIB PF00382.19 EWC43799.1 - 1.3e-36 124.5 0.6 9e-20 70.5 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EWC43799.1 - 1.9e-12 46.5 1.7 1.9e-12 46.5 1.7 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding Cyclin_N PF00134.23 EWC43799.1 - 0.0018 18.0 0.1 1.1 9.1 0.0 2.1 1 1 0 2 2 2 2 Cyclin, N-terminal domain SRPRB PF09439.10 EWC43799.1 - 0.0093 15.4 0.1 0.015 14.7 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Cyclin_C PF02984.19 EWC43799.1 - 0.011 15.8 0.1 2.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Cyclin, C-terminal domain TrmB PF01978.19 EWC43799.1 - 0.012 15.5 0.0 6.2 6.8 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 EWC43799.1 - 0.025 14.4 0.0 3.7 7.5 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family zf-ribbon_3 PF13248.6 EWC43799.1 - 0.15 11.5 0.0 0.15 11.5 0.0 2.5 3 0 0 3 3 3 0 zinc-ribbon domain TMIE PF16038.5 EWC43799.1 - 0.17 11.8 0.8 0.47 10.3 0.4 1.9 2 0 0 2 2 2 0 TMIE protein FANCL_C PF11793.8 EWC43801.1 - 1.2e-07 31.7 5.1 2.1e-07 31.0 5.1 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.7 EWC43801.1 - 1.5e-05 25.0 7.9 2.6e-05 24.2 7.9 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EWC43801.1 - 0.022 15.1 6.5 0.039 14.3 6.5 1.4 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 EWC43801.1 - 2.4 8.1 5.1 4.1 7.4 5.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 EWC43802.1 - 1.6e-51 175.2 0.0 2.1e-51 174.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43802.1 - 1.8e-31 109.4 0.0 2.2e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC43802.1 - 1.6e-05 25.0 0.0 4.5e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EWC43802.1 - 0.00055 19.4 0.0 0.0017 17.8 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EWC43802.1 - 0.031 13.6 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EWC43802.1 - 0.066 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EWC43802.1 - 0.11 12.0 0.0 1.4 8.5 0.0 2.0 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EWC43802.1 - 0.19 11.3 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.25 EWC43803.1 - 1.7e-52 178.4 0.1 2.3e-52 178.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43803.1 - 6e-22 78.2 0.1 1.2e-21 77.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EWC43803.1 - 0.011 14.8 0.1 0.018 14.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 EWC43803.1 - 7 5.3 10.2 0.047 12.5 0.4 2.2 2 1 0 2 2 2 0 Fungal protein kinase HlyIII PF03006.20 EWC43804.1 - 3.4e-62 210.1 11.8 4e-62 209.9 11.8 1.0 1 0 0 1 1 1 1 Haemolysin-III related Pox_I5 PF04713.12 EWC43804.1 - 0.07 13.2 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Poxvirus protein I5 DASH_Duo1 PF08651.10 EWC43806.1 - 4.6e-15 55.1 0.3 6.5e-15 54.7 0.3 1.1 1 0 0 1 1 1 1 DASH complex subunit Duo1 Laminin_II PF06009.12 EWC43806.1 - 0.023 14.7 0.9 0.031 14.3 0.9 1.1 1 0 0 1 1 1 0 Laminin Domain II DUF3168 PF11367.8 EWC43806.1 - 0.031 14.5 0.2 0.047 13.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3168) UTP15_C PF09384.10 EWC43806.1 - 0.036 13.8 0.1 0.047 13.4 0.1 1.2 1 0 0 1 1 1 0 UTP15 C terminal ANAPC4_WD40 PF12894.7 EWC43808.1 - 0.0015 18.8 0.1 7.9 6.9 0.0 4.2 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Pescadillo_N PF06732.11 EWC43809.1 - 6.6e-122 406.3 0.1 6.6e-122 406.3 0.1 1.9 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EWC43809.1 - 0.013 15.9 0.0 0.041 14.3 0.0 1.9 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain PRKG1_interact PF15898.5 EWC43810.1 - 1.8 9.5 8.3 0.14 13.0 0.6 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Glycos_transf_2 PF00535.26 EWC43811.1 - 2.8e-34 118.4 0.0 3.4e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EWC43811.1 - 4.4e-12 46.4 0.0 6.5e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EWC43811.1 - 0.00045 19.7 0.0 0.0007 19.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 EWC43811.1 - 0.002 17.6 0.0 0.0029 17.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EWC43811.1 - 0.19 12.3 0.0 0.44 11.1 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Laminin_G_3 PF13385.6 EWC43812.1 - 0.0046 17.1 0.3 0.008 16.3 0.3 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CBM_11 PF03425.13 EWC43812.1 - 0.031 14.2 0.1 0.047 13.6 0.1 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) CBM_4_9 PF02018.17 EWC43812.1 - 0.091 13.0 0.2 0.14 12.4 0.2 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain Peptidase_M24 PF00557.24 EWC43813.1 - 2e-47 161.6 0.0 2.4e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EWC43813.1 - 3.8e-21 75.1 9.7 3.8e-21 75.1 9.7 1.7 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EWC43813.1 - 0.00013 22.0 5.7 0.00013 22.0 5.7 2.4 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 EWC43813.1 - 1.7 8.6 4.9 4.2 7.3 4.9 1.7 1 0 0 1 1 1 0 HIT zinc finger Aminotran_1_2 PF00155.21 EWC43814.1 - 1.7e-39 136.1 0.0 2.1e-39 135.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EWC43814.1 - 0.0087 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase AA_permease_N PF08403.10 EWC43815.1 - 0.16 11.5 0.1 0.34 10.4 0.1 1.6 1 0 0 1 1 1 0 Amino acid permease N-terminal tRNA-synt_1 PF00133.22 EWC43816.1 - 3.6e-157 524.2 0.0 4.8e-157 523.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EWC43816.1 - 3.9e-23 82.1 0.6 7.7e-23 81.1 0.6 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EWC43816.1 - 2.9e-17 62.5 0.2 3.7e-09 35.8 0.0 4.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EWC43816.1 - 0.0014 18.1 0.0 0.054 12.8 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain zf-FPG_IleRS PF06827.14 EWC43816.1 - 0.0021 17.9 4.8 0.0092 15.8 0.4 2.5 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS tRNA-synt_1_2 PF13603.6 EWC43816.1 - 0.0089 15.6 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1f PF01921.18 EWC43816.1 - 0.089 11.7 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Ribosomal_L36 PF00444.18 EWC43817.1 - 2.8e-20 72.2 9.3 4.1e-20 71.7 9.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 Syja_N PF02383.18 EWC43818.1 - 1.9e-88 296.9 0.5 2.4e-88 296.6 0.5 1.1 1 0 0 1 1 1 1 SacI homology domain YlaC PF10777.9 EWC43818.1 - 0.52 10.1 1.7 1.6 8.6 1.7 1.8 1 0 0 1 1 1 0 Inner membrane protein YlaC PIG-U PF06728.13 EWC43819.1 - 3.2e-118 395.1 33.8 3.7e-118 394.9 33.8 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 EWC43819.1 - 4.6 6.9 18.2 0.3 10.8 12.7 1.9 2 1 0 2 2 2 0 8TM Microsporidial transmembrane domain Acetyltransf_1 PF00583.25 EWC43820.1 - 1.7e-12 47.6 0.1 2.5e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC43820.1 - 5e-06 26.5 0.0 7.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC43820.1 - 5.3e-06 26.8 0.1 8.3e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EWC43820.1 - 0.0069 16.3 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Complex1_LYR PF05347.15 EWC43821.1 - 2.1e-15 56.5 0.1 3.2e-15 55.9 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EWC43821.1 - 0.018 15.7 0.0 0.024 15.4 0.0 1.1 1 0 0 1 1 1 0 Complex1_LYR-like SDA1 PF05285.12 EWC43823.1 - 0.069 12.6 5.7 0.74 9.2 0.1 2.2 2 0 0 2 2 2 0 SDA1 DeoRC PF00455.22 EWC43823.1 - 0.18 11.7 0.0 0.31 11.0 0.0 1.3 1 0 0 1 1 1 0 DeoR C terminal sensor domain Sugar_tr PF00083.24 EWC43824.1 - 4.1e-101 339.1 21.4 5e-101 338.8 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC43824.1 - 2.9e-23 82.4 30.7 7.1e-17 61.4 13.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EWC43824.1 - 2.5e-05 23.0 19.0 0.00039 19.1 3.5 2.8 2 2 1 3 3 3 2 MFS/sugar transport protein OATP PF03137.20 EWC43824.1 - 2.4 6.4 17.6 0.091 11.0 1.6 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2701 PF10857.8 EWC43825.1 - 0.3 11.2 0.0 1e+02 3.0 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2701) MARVEL PF01284.23 EWC43826.1 - 1.5e-06 28.3 25.2 2.9e-05 24.1 25.2 2.1 1 1 1 2 2 2 2 Membrane-associating domain DUF2070 PF09843.9 EWC43826.1 - 2.4 6.3 13.6 2.8 6.1 13.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Fig1 PF12351.8 EWC43826.1 - 3.9 7.4 7.1 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 ABC2_membrane_5 PF13346.6 EWC43826.1 - 5.3 6.5 18.1 7.2 6.1 18.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein SPX PF03105.19 EWC43827.1 - 4.6 7.1 7.6 7.5 6.4 7.6 1.4 1 0 0 1 1 1 0 SPX domain Peptidase_M20 PF01546.28 EWC43828.1 - 6.2e-35 120.8 0.0 9.5e-35 120.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EWC43828.1 - 9.9e-09 35.1 0.1 2.5e-08 33.8 0.1 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EWC43828.1 - 2.1e-08 34.1 0.0 7.7e-08 32.3 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M28 Glyco_hydro_10 PF00331.20 EWC43829.1 - 2.9e-104 348.6 2.0 3.6e-104 348.3 2.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.18 EWC43829.1 - 4.5e-13 48.9 7.7 4.5e-13 48.9 7.7 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain Dicty_REP PF05086.12 EWC43829.1 - 0.0016 16.6 4.2 0.0025 15.9 4.2 1.3 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein TMEM151 PF14857.6 EWC43829.1 - 0.62 8.9 6.4 0.28 10.1 0.2 2.1 2 0 0 2 2 2 0 TMEM151 family Zn_clus PF00172.18 EWC43830.1 - 5.3e-07 29.7 11.2 8.3e-07 29.0 11.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EWC43830.1 - 4.6e-06 25.8 0.1 8.5e-06 25.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain AhpC-TSA PF00578.21 EWC43831.1 - 0.00029 20.7 0.0 0.00054 19.9 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 EWC43831.1 - 0.00082 19.2 0.0 0.0023 17.7 0.0 1.8 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin Tyrosinase PF00264.20 EWC43835.1 - 8.9e-43 147.1 0.2 1.2e-42 146.7 0.2 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase fn3_5 PF06280.12 EWC43836.1 - 0.049 14.3 2.2 0.45 11.2 0.0 2.7 2 0 0 2 2 2 0 Fn3-like domain HSDR_N_2 PF13588.6 EWC43837.1 - 2.9e-05 24.0 0.0 4e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) Peptidase_S78 PF04586.17 EWC43839.1 - 0.069 13.3 0.6 0.22 11.7 0.1 1.9 2 0 0 2 2 2 0 Caudovirus prohead serine protease Importin_rep_6 PF18829.1 EWC43839.1 - 0.093 12.9 1.3 5.4 7.2 0.3 2.6 2 0 0 2 2 2 0 Importin repeat 6 CFEM PF05730.11 EWC43840.1 - 0.021 14.9 5.0 0.021 14.9 5.0 2.6 2 0 0 2 2 2 0 CFEM domain PPP4R2 PF09184.11 EWC43840.1 - 9.2 5.8 8.6 3 7.3 3.5 1.9 2 0 0 2 2 2 0 PPP4R2 Pyr_redox_3 PF13738.6 EWC43841.1 - 4e-13 49.3 0.0 1.2e-10 41.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EWC43841.1 - 1.7e-10 40.0 0.0 1.1e-06 27.3 0.0 3.1 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EWC43841.1 - 1.8e-10 40.6 0.0 9.7e-06 25.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC43841.1 - 1.7e-09 37.9 0.2 0.00047 20.2 0.1 3.3 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 EWC43841.1 - 4.3e-08 32.7 0.0 0.00015 21.0 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EWC43841.1 - 1.4e-06 28.4 0.0 5.1e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EWC43841.1 - 1.1e-05 25.2 0.1 0.049 13.2 0.5 3.4 4 0 0 4 4 4 1 FAD dependent oxidoreductase Thi4 PF01946.17 EWC43841.1 - 7.7e-05 22.0 0.0 0.0002 20.7 0.0 1.6 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EWC43841.1 - 0.0022 16.8 0.5 1.7 7.3 0.0 2.9 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 EWC43841.1 - 0.03 13.4 0.2 0.12 11.4 0.2 1.9 1 1 0 1 1 1 0 Lycopene cyclase protein Amino_oxidase PF01593.24 EWC43841.1 - 0.04 13.2 0.0 5.9 6.0 0.0 2.6 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase GIDA PF01134.22 EWC43841.1 - 0.067 12.3 0.1 1.3 8.0 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF4246 PF14033.6 EWC43842.1 - 3.2e-127 425.4 0.1 4e-127 425.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) F-box PF00646.33 EWC43842.1 - 0.2 11.6 0.5 4.7 7.2 0.2 2.7 2 0 0 2 2 2 0 F-box domain Baculo_PEP_C PF04513.12 EWC43843.1 - 0.74 9.8 2.9 7.2 6.6 2.6 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MFS_1 PF07690.16 EWC43844.1 - 1.3e-25 90.1 64.6 5.1e-20 71.7 45.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C2H2 PF00096.26 EWC43845.1 - 1.1e-06 28.7 12.3 0.00074 19.8 3.3 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC43845.1 - 0.00011 22.8 11.8 0.016 16.0 2.8 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EWC43845.1 - 0.00037 20.8 2.8 0.00037 20.8 2.8 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EWC43845.1 - 0.016 15.5 4.5 0.37 11.1 1.2 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding BolA PF01722.18 EWC43845.1 - 0.21 11.9 0.9 0.44 10.9 0.9 1.5 1 0 0 1 1 1 0 BolA-like protein zf-met PF12874.7 EWC43845.1 - 0.27 11.7 6.8 0.74 10.3 1.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 EWC43845.1 - 0.32 11.7 3.0 5 7.8 0.3 2.3 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf_C2H2_ZHX PF18387.1 EWC43845.1 - 2.2 8.0 5.0 2.4 7.9 2.8 2.0 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain adh_short_C2 PF13561.6 EWC43846.1 - 6.7e-47 160.0 0.0 7.8e-47 159.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EWC43846.1 - 2.2e-34 118.6 0.0 2.9e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EWC43846.1 - 6.4e-05 22.9 0.1 0.0001 22.2 0.1 1.4 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EWC43846.1 - 0.0095 15.3 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EWC43846.1 - 0.019 14.4 0.0 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EWC43847.1 - 2.9e-44 150.9 0.0 3.8e-44 150.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC43847.1 - 3.8e-37 128.1 0.0 5.1e-37 127.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC43847.1 - 0.0016 18.4 0.3 0.036 14.0 0.1 2.2 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EWC43847.1 - 0.11 12.0 0.1 2.2 7.7 0.1 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Beta-lactamase PF00144.24 EWC43848.1 - 5.7e-34 117.8 0.0 9.1e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase TPR_1 PF00515.28 EWC43849.1 - 1.3e-06 28.0 0.0 0.0092 15.8 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EWC43849.1 - 0.00017 21.4 0.0 0.28 11.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EWC43849.1 - 0.0006 20.4 0.1 0.006 17.2 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EWC43849.1 - 0.0042 16.7 0.0 2 8.2 0.0 2.7 2 0 0 2 2 2 2 TPR repeat TPR_19 PF14559.6 EWC43849.1 - 0.01 16.3 0.1 1.9 9.1 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EWC43849.1 - 0.024 15.3 0.1 5.2 7.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EWC43849.1 - 0.029 14.1 0.2 0.051 13.3 0.2 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_14 PF13428.6 EWC43849.1 - 0.03 15.1 0.1 16 6.6 0.0 3.3 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EWC43849.1 - 0.049 13.9 0.8 5.2 7.5 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EWC43849.1 - 0.15 12.2 0.0 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DIOX_N PF14226.6 EWC43850.1 - 4.3e-35 121.0 0.0 6.5e-35 120.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EWC43850.1 - 6.1e-22 78.0 0.0 1.1e-21 77.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box PF00646.33 EWC43851.1 - 3e-07 30.2 0.1 5.1e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 F-box domain Skp1_POZ PF03931.15 EWC43851.1 - 0.13 12.4 0.6 0.31 11.3 0.0 1.8 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Peptidase_S8 PF00082.22 EWC43852.1 - 1.1e-25 90.5 3.7 7.3e-25 87.8 3.7 2.0 1 1 0 1 1 1 1 Subtilase family LCIB_C_CA PF18599.1 EWC43852.1 - 0.25 10.6 0.0 0.25 10.6 0.0 1.5 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Ricin_B_lectin PF00652.22 EWC43853.1 - 7.4e-21 74.7 0.9 1.3e-20 73.9 0.9 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Cellulase PF00150.18 EWC43853.1 - 3.8e-20 72.5 7.3 1.1e-19 71.0 7.3 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) RicinB_lectin_2 PF14200.6 EWC43853.1 - 5.7e-11 43.0 4.6 8.6e-06 26.4 1.9 3.2 2 1 0 3 3 3 2 Ricin-type beta-trefoil lectin domain-like Glyco_hydro_42 PF02449.15 EWC43853.1 - 1e-05 25.1 0.0 3.2e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_1 PF00232.18 EWC43853.1 - 7.4e-05 21.3 0.2 0.00012 20.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_5_C PF18564.1 EWC43853.1 - 0.0002 21.8 0.5 0.00056 20.4 0.3 1.9 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_72 PF03198.14 EWC43853.1 - 0.0047 16.2 0.3 0.0095 15.2 0.3 1.4 1 1 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_35 PF01301.19 EWC43853.1 - 0.036 13.7 0.3 0.069 12.8 0.3 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 DUF648 PF04890.13 EWC43853.1 - 0.16 11.7 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF648) DUF1943 PF09172.11 EWC43854.1 - 4.9e-09 35.9 42.3 0.0035 16.6 11.4 3.1 1 1 2 3 3 3 3 Domain of unknown function (DUF1943) DUF1062 PF06353.12 EWC43854.1 - 9.6e-05 23.2 7.1 18 6.2 7.1 3.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1062) DUF3194 PF11419.8 EWC43854.1 - 0.028 14.8 42.7 1.8e+04 -25.7 42.7 5.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3194) Noc2 PF03715.13 EWC43855.1 - 7.2e-123 409.6 0.0 2.1e-122 408.1 0.0 1.8 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 EWC43855.1 - 0.015 13.5 0.0 0.015 13.5 0.0 4.0 2 2 1 3 3 3 0 Nop14-like family DUF2749 PF10907.8 EWC43857.1 - 0.17 12.0 2.0 0.32 11.2 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) Nterm_IS4 PF13006.7 EWC43857.1 - 0.2 11.8 1.8 0.29 11.3 0.9 1.7 2 0 0 2 2 2 0 Insertion element 4 transposase N-terminal CLTH PF10607.9 EWC43858.1 - 3.3e-31 108.2 0.0 4.9e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EWC43858.1 - 1.5e-08 34.5 0.3 2.9e-08 33.6 0.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EWC43858.1 - 0.0023 17.3 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.6 EWC43858.1 - 0.0068 16.7 0.3 0.012 16.0 0.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC43858.1 - 0.0074 16.1 0.7 0.014 15.3 0.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC43858.1 - 0.0085 15.9 0.4 0.015 15.1 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC43858.1 - 0.01 15.7 0.1 0.018 15.0 0.1 1.3 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EWC43858.1 - 0.018 14.9 0.4 0.033 14.0 0.4 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EWC43858.1 - 0.031 14.4 0.5 0.06 13.5 0.5 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EWC43858.1 - 0.064 13.1 0.2 0.11 12.4 0.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EWC43858.1 - 0.4 10.5 1.4 0.78 9.6 1.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Utp11 PF03998.13 EWC43859.1 - 5.5e-58 196.8 7.2 6.1e-58 196.6 7.2 1.0 1 0 0 1 1 1 1 Utp11 protein Rad50_zn_hook PF04423.14 EWC43860.1 - 0.96 9.3 2.4 1.6 8.7 2.4 1.3 1 0 0 1 1 1 0 Rad50 zinc hook motif Bac_export_2 PF01312.19 EWC43860.1 - 6.5 5.9 7.6 0.89 8.7 2.9 1.7 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family LRR_4 PF12799.7 EWC43861.1 - 9.4e-30 102.2 33.4 6.3e-08 32.8 5.2 7.1 2 2 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EWC43861.1 - 1.2e-20 73.1 30.6 8.4e-07 28.7 6.1 5.9 2 1 3 6 6 6 6 Leucine rich repeat LRR_9 PF14580.6 EWC43861.1 - 1.9e-15 56.8 11.1 1e-06 28.4 0.5 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EWC43861.1 - 0.0009 19.5 28.1 3 8.7 0.1 9.2 10 1 0 10 10 10 2 Leucine Rich Repeat LRR_6 PF13516.6 EWC43861.1 - 0.016 15.2 28.6 0.3 11.3 0.4 8.1 10 0 0 10 10 10 0 Leucine Rich repeat PCI PF01399.27 EWC43862.1 - 3.2e-13 50.1 0.0 8.5e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 PCI domain Cmc1 PF08583.10 EWC43863.1 - 1.9e-19 69.4 4.9 1.9e-19 69.4 4.9 1.5 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 EWC43863.1 - 7.1e-05 22.4 2.0 0.00011 21.8 2.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.13 EWC43863.1 - 0.00043 20.3 2.1 0.00069 19.7 2.1 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 EWC43863.1 - 0.03 14.3 0.3 0.051 13.6 0.3 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, RuvC_III PF18541.1 EWC43863.1 - 0.036 14.0 1.1 0.038 13.9 1.1 1.1 1 0 0 1 1 1 0 RuvC endonuclease subdomain 3 DUF3128 PF11326.8 EWC43863.1 - 0.93 9.9 9.6 69 3.9 9.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) MMM1 PF10296.9 EWC43864.1 - 1.9e-05 23.9 0.0 3.4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 SUIM_assoc PF16619.5 EWC43864.1 - 6.2 7.0 12.9 13 6.0 0.7 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TFIID-31kDa PF02291.15 EWC43865.1 - 2.7e-48 163.1 0.0 3.3e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit GAS PF13851.6 EWC43867.1 - 0.0033 16.8 27.3 0.12 11.7 12.8 2.9 2 2 0 2 2 2 2 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EWC43867.1 - 0.018 15.1 29.2 0.056 13.5 4.5 3.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EWC43867.1 - 0.036 14.6 33.7 0.064 13.8 8.2 3.7 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF4094 PF13334.6 EWC43867.1 - 0.24 11.8 2.6 1.8 9.0 1.0 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DUF724 PF05266.14 EWC43867.1 - 0.42 10.4 18.5 0.031 14.1 1.8 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF724) JIP_LZII PF16471.5 EWC43867.1 - 0.42 10.8 28.5 0.34 11.1 0.9 6.2 4 2 3 7 7 7 0 JNK-interacting protein leucine zipper II SlyX PF04102.12 EWC43867.1 - 1.6 9.4 0.0 1.6 9.4 0.0 3.8 4 2 1 5 5 4 0 SlyX Spc7 PF08317.11 EWC43867.1 - 3.8 6.3 30.7 3.1 6.6 7.9 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein MitMem_reg PF13012.6 EWC43867.1 - 4.6 7.7 7.2 1.6 9.2 0.5 2.8 3 0 0 3 3 2 0 Maintenance of mitochondrial structure and function Seryl_tRNA_N PF02403.22 EWC43867.1 - 6.7 7.0 19.1 1.7 8.9 0.4 3.7 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 EWC43867.1 - 7.1 6.7 8.7 21 5.1 0.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 EWC43867.1 - 7.6 6.8 22.2 3 8.1 7.0 3.6 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) CALCOCO1 PF07888.11 EWC43867.1 - 9.8 4.9 31.0 5.5 5.7 3.0 2.3 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like BLOC1_2 PF10046.9 EWC43868.1 - 0.1 12.9 0.2 0.2 11.9 0.2 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MCM3AP_GANP PF16769.5 EWC43868.1 - 0.2 9.9 0.1 0.26 9.5 0.1 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP fn3 PF00041.21 EWC43870.1 - 2e-10 40.9 0.1 4.8e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 EWC43870.1 - 0.069 13.7 0.0 0.38 11.4 0.0 2.4 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Laminin_I PF06008.14 EWC43870.1 - 0.72 9.5 24.6 1.4 8.6 24.6 1.4 1 0 0 1 1 1 0 Laminin Domain I OmpH PF03938.14 EWC43870.1 - 2.8 8.3 26.9 0.029 14.7 15.6 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.9 EWC43870.1 - 2.8 8.1 37.6 33 4.7 20.1 2.5 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF812 PF05667.11 EWC43870.1 - 9.1 5.0 33.1 26 3.5 33.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) LNS2 PF08235.13 EWC43871.1 - 2.9e-95 318.1 0.0 4.4e-95 317.4 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EWC43871.1 - 9e-42 141.2 0.0 1.8e-41 140.2 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region AlaDh_PNT_N PF05222.15 EWC43872.1 - 1.3e-25 90.3 0.0 1.8e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EWC43872.1 - 1.9e-05 24.1 0.0 0.00032 20.1 0.0 2.1 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain RNA_pol_Rpb1_1 PF04997.12 EWC43873.1 - 2.1e-113 378.8 0.0 4e-113 377.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EWC43873.1 - 3.1e-104 348.2 0.2 4.8e-104 347.5 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EWC43873.1 - 1.3e-76 256.4 0.0 2.5e-76 255.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EWC43873.1 - 5.4e-60 202.5 1.5 8.9e-60 201.8 1.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EWC43873.1 - 1.1e-45 155.4 0.0 2.4e-45 154.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EWC43873.1 - 1.1e-43 148.4 4.2 2.2e-43 147.5 4.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EWC43873.1 - 2.3e-36 124.0 0.2 6e-36 122.7 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EWC43873.1 - 6.4e-09 35.7 212.6 0.0062 16.8 11.3 14.3 9 1 10 19 19 19 14 RNA polymerase Rpb1 C-terminal repeat WD40 PF00400.32 EWC43874.1 - 4.5e-14 52.6 10.1 2.2e-06 28.3 0.6 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC43874.1 - 7.3e-09 35.8 0.4 0.19 12.0 0.0 4.3 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EWC43874.1 - 0.083 11.4 0.3 3.4 6.1 0.0 2.7 2 1 1 3 3 3 0 Cytochrome D1 heme domain CopG_antitoxin PF12441.8 EWC43874.1 - 0.16 12.5 0.7 0.37 11.4 0.7 1.6 1 0 0 1 1 1 0 CopG antitoxin of type II toxin-antitoxin system CSN7a_helixI PF18392.1 EWC43875.1 - 1.1e-06 28.4 0.4 2.4e-06 27.3 0.4 1.6 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 EWC43875.1 - 1.5e-05 25.4 0.1 3.5e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 PCI domain Ribosomal_60s PF00428.19 EWC43875.1 - 2.9 8.5 6.6 0.63 10.7 1.6 2.3 3 1 0 3 3 3 0 60s Acidic ribosomal protein FG-GAP PF01839.23 EWC43877.1 - 0.00012 22.1 12.9 0.0057 16.8 4.9 2.9 1 1 1 2 2 2 2 FG-GAP repeat VCBS PF13517.6 EWC43877.1 - 0.00042 20.9 7.6 0.052 14.1 0.9 3.0 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Trypan_PARP PF05887.11 EWC43877.1 - 0.0096 15.9 7.9 0.0096 15.9 7.9 2.0 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) EF-hand_5 PF13202.6 EWC43877.1 - 0.9 9.1 4.0 32 4.2 0.1 3.2 3 0 0 3 3 3 0 EF hand EF-hand_1 PF00036.32 EWC43877.1 - 1.2 8.8 2.7 53 3.7 0.1 3.1 3 0 0 3 3 3 0 EF hand HMA PF00403.26 EWC43878.1 - 1.7e-47 159.7 6.9 2e-13 50.6 0.3 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 EWC43878.1 - 5.1e-47 159.7 0.2 5.1e-47 159.7 0.2 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EWC43878.1 - 2e-38 132.8 2.3 2e-38 132.8 2.3 2.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EWC43878.1 - 3.9e-06 26.8 2.4 0.00018 21.3 2.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase B12-binding PF02310.19 EWC43878.1 - 0.013 15.5 0.5 19 5.3 0.1 3.6 3 0 0 3 3 3 0 B12 binding domain Thg1 PF04446.12 EWC43879.1 - 1.5e-48 164.0 0.0 2.2e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EWC43879.1 - 1.6e-46 157.4 3.1 1.3e-45 154.5 3.1 2.0 1 1 0 1 1 1 1 Thg1 C terminal domain Peptidase_M16 PF00675.20 EWC43880.1 - 2.6e-55 186.5 0.5 6.2e-55 185.3 0.5 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EWC43880.1 - 1.6e-39 135.8 0.0 6.7e-38 130.5 0.0 2.8 3 0 0 3 3 3 1 Peptidase M16 inactive domain CybS PF05328.12 EWC43881.1 - 5.6e-50 168.5 0.0 8e-50 168.0 0.0 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Apolipoprotein PF01442.18 EWC43882.1 - 5.3e-06 26.4 4.2 5.3e-06 26.4 4.2 2.6 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EWC43882.1 - 0.00027 21.0 4.1 0.00027 21.0 4.1 2.5 3 1 0 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1515 PF07439.11 EWC43882.1 - 0.033 14.2 2.9 0.057 13.4 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) XhlA PF10779.9 EWC43882.1 - 0.27 11.5 4.5 0.16 12.2 1.3 2.3 2 0 0 2 2 2 0 Haemolysin XhlA Med29 PF11568.8 EWC43882.1 - 0.39 10.9 7.0 0.41 10.9 0.3 3.1 3 0 0 3 3 3 0 Mediator complex subunit 29 DUF1664 PF07889.12 EWC43882.1 - 1 9.4 15.3 0.24 11.5 2.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EWC43882.1 - 1.1 9.3 14.9 0.25 11.3 0.9 3.5 4 0 0 4 4 4 0 Laminin Domain II FAM76 PF16046.5 EWC43882.1 - 2.9 7.2 12.7 8.9 5.6 12.3 1.9 1 1 1 2 2 2 0 FAM76 protein FlaC_arch PF05377.11 EWC43882.1 - 3.8 8.0 10.3 0.46 10.9 2.1 3.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DUF4618 PF15397.6 EWC43882.1 - 6.8 6.0 11.9 8.4 5.7 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF148 PF02520.17 EWC43882.1 - 9.2 6.4 8.6 0.78 9.9 0.2 3.0 2 1 1 3 3 3 0 Domain of unknown function DUF148 KfrA_N PF11740.8 EWC43883.1 - 0.0086 16.8 5.5 0.0096 16.6 4.3 1.7 2 0 0 2 2 2 1 Plasmid replication region DNA-binding N-term APG6_N PF17675.1 EWC43883.1 - 0.07 13.7 3.4 0.14 12.6 3.4 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Ada3 PF10198.9 EWC43884.1 - 2.5e-49 166.8 1.6 2.5e-49 166.8 1.6 2.3 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 FlxA PF14282.6 EWC43884.1 - 1.1 9.3 8.3 10 6.2 7.4 2.6 2 0 0 2 2 2 0 FlxA-like protein V_ATPase_I PF01496.19 EWC43884.1 - 1.4 6.7 8.2 3.9 5.3 0.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family CoA_transf_3 PF02515.17 EWC43885.1 - 9.1e-63 212.6 0.0 1.3e-62 212.1 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III F-box-like PF12937.7 EWC43886.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 F-box-like Amidohydro_1 PF01979.20 EWC43887.1 - 1.4e-70 238.3 0.1 2.5e-70 237.5 0.1 1.4 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 EWC43887.1 - 1.7e-56 189.7 5.0 1.6e-55 186.6 3.2 2.4 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 EWC43887.1 - 1.1e-41 140.8 1.2 2.3e-41 139.8 0.2 2.0 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.18 EWC43887.1 - 1.6e-40 137.4 0.2 3.5e-40 136.3 0.2 1.6 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 EWC43887.1 - 3.3e-09 36.7 0.1 1e-07 31.8 0.0 2.4 2 0 0 2 2 2 1 Amidohydrolase family HMG_box PF00505.19 EWC43888.1 - 2.5e-13 50.2 2.6 5.9e-13 49.0 2.6 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EWC43888.1 - 1.4e-05 25.6 1.9 1.4e-05 25.6 1.9 2.0 2 0 0 2 2 2 1 HMG-box domain CRISPR_Cse2 PF09485.10 EWC43888.1 - 0.7 10.4 4.5 1.1 9.8 4.3 1.6 1 1 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) SAPS PF04499.15 EWC43888.1 - 3.4 6.4 8.0 4 6.1 8.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pyridoxal_deC PF00282.19 EWC43890.1 - 1.5e-74 250.9 0.0 1.9e-74 250.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EWC43890.1 - 1.6e-06 27.6 0.0 2.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EWC43890.1 - 1.4e-05 24.3 0.0 2.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Gamma_PGA_hydro PF05908.11 EWC43890.1 - 0.039 13.3 0.0 0.073 12.5 0.0 1.3 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase Aminotran_1_2 PF00155.21 EWC43890.1 - 0.044 12.9 0.0 1.7 7.7 0.0 2.1 2 0 0 2 2 2 0 Aminotransferase class I and II Ank_2 PF12796.7 EWC43892.1 - 3.8e-110 360.7 10.9 6.5e-15 55.5 0.0 13.4 5 4 9 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC43892.1 - 4.4e-77 253.5 20.4 2.3e-12 47.2 0.0 18.0 11 3 9 20 20 20 16 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC43892.1 - 4.3e-73 232.5 18.7 1.2e-05 25.3 0.2 25.0 27 0 0 27 27 27 13 Ankyrin repeat Ank_5 PF13857.6 EWC43892.1 - 6e-65 214.5 25.3 2.8e-09 37.1 0.0 19.7 12 3 11 23 23 23 15 Ankyrin repeats (many copies) Ank PF00023.30 EWC43892.1 - 1.6e-60 199.0 25.1 2e-05 24.8 0.1 20.8 22 1 1 23 23 23 12 Ankyrin repeat SPRY PF00622.28 EWC43892.1 - 1.1e-14 54.6 0.0 3.7e-14 52.9 0.0 1.9 2 0 0 2 2 2 1 SPRY domain ABC_tran PF00005.27 EWC43892.1 - 0.0059 17.1 0.0 0.024 15.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 EWC43892.1 - 0.035 14.5 0.0 0.2 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 EWC43892.1 - 0.2 11.5 0.0 0.4 10.6 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Peptidase_S8 PF00082.22 EWC43894.1 - 2.6e-13 49.9 0.1 5.9e-13 48.7 0.1 1.6 1 0 0 1 1 1 1 Subtilase family Ank PF00023.30 EWC43894.1 - 0.00094 19.5 0.3 0.004 17.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EWC43894.1 - 0.063 13.9 1.6 0.25 11.9 0.8 2.4 1 1 2 3 3 3 0 Ankyrin repeats (3 copies) DcpS_C PF11969.8 EWC43894.1 - 0.17 12.4 0.1 0.35 11.3 0.1 1.5 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding E1-E2_ATPase PF00122.20 EWC43895.1 - 1.7e-39 135.2 7.0 4.5e-31 107.8 0.0 3.1 2 1 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EWC43895.1 - 1.1e-23 83.9 9.7 1.1e-23 83.9 9.7 2.4 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EWC43895.1 - 3.3e-20 73.3 0.0 1.6e-18 67.8 0.0 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EWC43895.1 - 6.7e-15 55.0 0.0 1.3e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EWC43895.1 - 0.00021 21.1 0.1 0.0046 16.7 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CoA_binding_3 PF13727.6 EWC43895.1 - 0.12 12.4 1.2 2.1 8.3 1.0 2.6 2 0 0 2 2 2 0 CoA-binding domain Lipase_3 PF01764.25 EWC43896.1 - 4.8e-27 94.6 0.0 6.5e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EWC43896.1 - 0.0012 19.5 0.3 0.0017 19.0 0.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family AAA PF00004.29 EWC43897.1 - 8.3e-43 146.0 0.0 1.7e-42 145.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC43897.1 - 1.4e-12 47.2 0.0 2.5e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EWC43897.1 - 9.1e-12 44.8 0.1 1.9e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EWC43897.1 - 3.8e-07 30.6 0.0 0.00015 22.2 0.1 2.7 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 EWC43897.1 - 1.3e-06 28.4 0.1 2.7e-05 24.2 0.1 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EWC43897.1 - 2.5e-06 27.7 0.0 6.3e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EWC43897.1 - 7.3e-06 25.8 0.0 1.7e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EWC43897.1 - 0.00017 21.9 0.1 0.0046 17.2 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EWC43897.1 - 0.00023 20.4 0.0 0.00082 18.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EWC43897.1 - 0.00089 19.8 0.2 0.0053 17.3 0.0 2.4 3 1 0 3 3 2 1 AAA domain AAA_7 PF12775.7 EWC43897.1 - 0.0019 17.8 0.0 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 EWC43897.1 - 0.0026 17.2 0.0 0.0053 16.2 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EWC43897.1 - 0.0034 16.6 0.0 0.0063 15.8 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 EWC43897.1 - 0.0041 17.1 0.0 0.0099 15.9 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EWC43897.1 - 0.0047 16.7 0.0 0.016 14.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EWC43897.1 - 0.0058 16.8 0.0 0.014 15.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 EWC43897.1 - 0.006 17.0 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 EWC43897.1 - 0.007 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EWC43897.1 - 0.0076 16.3 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 EWC43897.1 - 0.0082 15.8 0.1 0.022 14.4 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain Sigma54_activat PF00158.26 EWC43897.1 - 0.0084 15.8 0.0 0.026 14.2 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EWC43897.1 - 0.013 15.3 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EWC43897.1 - 0.021 14.5 0.1 0.066 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EWC43897.1 - 0.026 13.9 0.2 0.12 11.8 0.0 2.2 3 0 0 3 3 3 0 KaiC NACHT PF05729.12 EWC43897.1 - 0.035 14.0 0.1 0.084 12.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_11 PF13086.6 EWC43897.1 - 0.055 13.3 0.2 0.27 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EWC43897.1 - 0.055 13.7 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EWC43897.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 EWC43897.1 - 0.077 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EWC43897.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Med4 PF10018.9 EWC43897.1 - 0.13 12.0 0.5 0.24 11.1 0.5 1.4 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 CPT PF07931.12 EWC43897.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Enolase_C PF00113.22 EWC43898.1 - 7.7e-150 498.1 0.1 1e-149 497.6 0.1 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EWC43898.1 - 1.9e-54 183.4 0.0 3.2e-54 182.6 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EWC43898.1 - 1.5e-07 31.2 0.0 2.5e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like F-box-like PF12937.7 EWC43899.1 - 0.016 15.1 0.1 0.033 14.1 0.1 1.6 1 0 0 1 1 1 0 F-box-like Pro_isomerase PF00160.21 EWC43901.1 - 1.7e-48 164.9 0.4 2.3e-48 164.4 0.4 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FSA_C PF10479.9 EWC43901.1 - 0.042 12.0 1.1 0.059 11.5 1.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TMEM154 PF15102.6 EWC43901.1 - 0.052 13.5 0.1 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF4381 PF14316.6 EWC43901.1 - 0.24 11.6 0.0 0.41 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) CPSase_L_D2 PF02786.17 EWC43902.1 - 5.3e-82 274.4 0.0 8.3e-82 273.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EWC43902.1 - 3.7e-70 235.7 0.0 6.2e-70 235.0 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EWC43902.1 - 5.9e-39 133.0 0.1 1.4e-38 131.8 0.1 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EWC43902.1 - 4.5e-31 107.1 0.0 1.9e-30 105.1 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EWC43902.1 - 9.7e-29 100.7 0.0 2e-28 99.7 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EWC43902.1 - 4.3e-18 64.9 3.7 1.3e-17 63.4 3.7 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EWC43902.1 - 5.4e-11 42.4 0.0 1.2e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 EWC43902.1 - 9.5e-11 41.4 2.8 6.9e-08 32.2 0.3 3.0 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 EWC43902.1 - 1.4e-06 28.0 0.0 3e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 EWC43902.1 - 0.00015 21.0 0.2 0.0055 15.9 0.1 2.6 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 EWC43902.1 - 0.00026 21.1 0.0 0.0007 19.7 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 EWC43902.1 - 0.00048 20.8 1.5 1.1 10.0 0.1 3.1 3 0 0 3 3 2 2 HlyD family secretion protein RimK PF08443.11 EWC43902.1 - 0.0063 16.1 0.0 0.017 14.7 0.0 1.6 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 EWC43902.1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 EWC43902.1 - 0.023 14.5 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RnfC_N PF13375.6 EWC43902.1 - 0.024 14.6 1.8 0.14 12.1 1.8 2.3 1 1 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATPgrasp_ST PF14397.6 EWC43902.1 - 0.03 13.6 0.0 0.078 12.2 0.0 1.6 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp DUF2118 PF09891.9 EWC43902.1 - 0.034 14.1 0.1 0.095 12.6 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) GCV_H PF01597.19 EWC43902.1 - 0.041 13.8 1.4 0.17 11.8 0.5 2.4 1 1 1 2 2 2 0 Glycine cleavage H-protein NQRA PF05896.11 EWC43902.1 - 0.1 12.0 0.3 0.19 11.1 0.3 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) PYNP_C PF07831.13 EWC43902.1 - 0.33 10.6 1.7 2.5 7.8 0.0 2.9 3 0 0 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain Clathrin PF00637.20 EWC43903.1 - 1.8e-199 653.6 32.3 3.9e-32 111.1 0.3 7.8 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 EWC43903.1 - 4.2e-38 127.8 0.8 5.1e-08 32.8 0.1 6.6 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin_H_link PF13838.6 EWC43903.1 - 1.9e-29 101.4 2.1 4.7e-29 100.1 0.2 2.9 3 0 0 3 3 3 1 Clathrin-H-link TPR_14 PF13428.6 EWC43903.1 - 2.2e-05 24.9 4.3 20 6.3 0.1 8.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_8 PF13181.6 EWC43903.1 - 0.00012 22.0 1.3 2.3 8.6 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EWC43903.1 - 0.002 17.2 3.0 0.14 11.2 0.1 3.7 4 0 0 4 4 4 1 Coatomer WD associated region TPR_2 PF07719.17 EWC43903.1 - 0.0028 17.6 2.7 13 6.2 0.1 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC43903.1 - 0.0045 16.8 1.6 11 6.0 0.2 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EWC43903.1 - 0.0058 16.6 4.6 44 4.4 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Clathrin-link PF09268.10 EWC43903.1 - 0.0072 15.7 1.0 0.0072 15.7 1.0 2.5 3 0 0 3 3 3 1 Clathrin, heavy-chain linker DUF1467 PF07330.12 EWC43904.1 - 0.082 12.9 1.6 0.091 12.7 1.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) ArfGap PF01412.18 EWC43906.1 - 2.5e-34 117.9 0.0 1.1e-33 115.7 0.0 2.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EWC43906.1 - 1.7e-17 63.9 12.8 3e-17 63.1 12.8 1.2 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EWC43906.1 - 1e-12 48.5 0.1 3.2e-12 46.9 0.1 1.9 1 0 0 1 1 1 1 PH domain Neur_chan_memb PF02932.16 EWC43906.1 - 0.095 12.7 5.1 0.25 11.4 5.1 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PH_9 PF15410.6 EWC43906.1 - 0.79 10.1 2.9 0.54 10.6 0.4 2.1 2 1 0 2 2 2 0 Pleckstrin homology domain GAS PF13851.6 EWC43906.1 - 1.6 8.0 14.0 3.7 6.9 10.2 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Prion_bPrPp PF11587.8 EWC43907.1 - 0.31 10.9 1.9 0.68 9.8 1.9 1.6 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal LSM PF01423.22 EWC43908.1 - 1.9e-16 59.5 0.0 2.4e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_L5_C PF00673.21 EWC43909.1 - 9.2e-22 77.0 0.0 1.4e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EWC43909.1 - 1.7e-21 76.3 0.0 5.1e-21 74.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 EWC43909.1 - 0.072 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain RhoGAP PF00620.27 EWC43911.1 - 3.2e-43 147.2 0.1 6.2e-43 146.2 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EWC43911.1 - 2e-14 53.9 0.0 4.7e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EWC43911.1 - 0.19 12.0 0.0 0.58 10.5 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3450 PF11932.8 EWC43911.1 - 2.3 7.5 9.1 0.029 13.7 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) CFEM PF05730.11 EWC43912.1 - 2.2e-06 27.6 2.1 3.8e-06 26.9 2.1 1.3 1 0 0 1 1 1 1 CFEM domain TIL PF01826.17 EWC43912.1 - 0.52 10.6 4.6 1.1 9.6 4.6 1.5 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain WBS_methylT PF12589.8 EWC43914.1 - 3e-15 56.7 5.8 5.2e-15 56.0 5.8 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EWC43914.1 - 2.1e-13 50.8 0.1 5.8e-13 49.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC43914.1 - 2.2e-12 47.5 0.0 9e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC43914.1 - 7.7e-07 29.8 0.0 2.3e-06 28.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC43914.1 - 1.2e-05 25.1 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC43914.1 - 0.00013 21.8 0.0 0.00039 20.3 0.0 1.6 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EWC43914.1 - 0.00028 20.7 0.0 0.00048 19.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EWC43914.1 - 0.0036 16.8 0.0 0.0067 15.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 EWC43914.1 - 0.0052 16.8 0.1 0.38 10.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 EWC43914.1 - 0.025 13.9 0.0 0.12 11.7 0.0 1.9 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MetW PF07021.12 EWC43914.1 - 0.026 14.1 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.14 EWC43914.1 - 0.077 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain eIF2_C PF09173.11 EWC43916.1 - 1.2e-32 111.9 0.3 2.9e-32 110.8 0.3 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 EWC43916.1 - 4e-12 46.3 0.5 8.4e-12 45.3 0.5 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 EWC43916.1 - 2.2e-08 33.9 0.4 1.1e-06 28.3 0.5 2.8 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain OTT_1508_deam PF14441.6 EWC43916.1 - 1.3e-07 31.6 0.1 3e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase MMR_HSR1 PF01926.23 EWC43916.1 - 0.043 13.9 0.0 0.098 12.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Elicitin PF00964.17 EWC43916.1 - 0.08 13.0 0.6 9.9 6.3 0.1 2.5 2 0 0 2 2 2 0 Elicitin 7TMR-HDED PF07697.11 EWC43916.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.6 2 0 0 2 2 2 0 7TM-HD extracellular MMR_HSR1_Xtn PF16897.5 EWC43916.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Iso_dh PF00180.20 EWC43917.1 - 5.5e-80 269.1 0.0 6.7e-80 268.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Synthase_beta PF11421.8 EWC43917.1 - 0.089 13.5 2.2 0.22 12.2 1.2 2.1 2 0 0 2 2 2 0 ATP synthase F1 beta subunit Erv26 PF04148.13 EWC43918.1 - 5.8e-81 271.2 0.1 6.6e-81 271.0 0.1 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Ribosomal_S13 PF00416.22 EWC43919.1 - 1e-22 80.9 0.8 8.5e-21 74.7 0.8 2.1 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EWC43919.1 - 0.00014 20.8 0.0 0.00016 20.6 0.0 1.2 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_5 PF14520.6 EWC43919.1 - 0.029 15.0 0.0 0.51 11.0 0.0 2.4 2 1 1 3 3 3 0 Helix-hairpin-helix domain Glyco_hydro_47 PF01532.20 EWC43921.1 - 2e-163 544.6 0.0 2.4e-163 544.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 GlcNAc_2-epim PF07221.11 EWC43921.1 - 0.058 12.6 0.0 13 4.9 0.0 2.9 3 0 0 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) PRA1 PF03208.19 EWC43923.1 - 2.8e-30 104.8 0.1 3.5e-30 104.5 0.1 1.1 1 0 0 1 1 1 1 PRA1 family protein DnaJ PF00226.31 EWC43924.1 - 1.7e-06 28.0 0.1 1.9e-05 24.7 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain HLH PF00010.26 EWC43926.1 - 3.6e-06 26.8 0.0 1.1e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain APG17 PF04108.12 EWC43927.1 - 0.047 12.8 0.1 0.067 12.3 0.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 Ldh_1_N PF00056.23 EWC43928.1 - 1.9e-33 115.5 0.5 3.6e-33 114.6 0.5 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EWC43928.1 - 3.2e-22 79.2 0.0 6.7e-22 78.2 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain ApbA PF02558.16 EWC43928.1 - 7.9e-05 22.3 0.9 0.00017 21.3 0.9 1.6 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 EWC43928.1 - 0.00018 21.6 0.2 0.0041 17.1 0.0 2.8 2 1 1 3 3 3 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus OCD_Mu_crystall PF02423.15 EWC43928.1 - 0.0016 17.4 0.5 0.0032 16.5 0.5 1.4 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family 3HCDH_N PF02737.18 EWC43928.1 - 0.002 18.0 0.2 0.0039 17.1 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 EWC43928.1 - 0.0031 16.9 0.1 0.0078 15.6 0.1 1.6 1 0 0 1 1 1 1 ThiF family AlaDh_PNT_C PF01262.21 EWC43928.1 - 0.005 16.2 0.3 0.0095 15.2 0.3 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EWC43928.1 - 0.012 15.2 0.9 0.13 11.8 0.9 2.2 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 EWC43928.1 - 0.016 14.4 0.1 0.028 13.7 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC43928.1 - 0.019 14.5 2.1 0.033 13.8 1.2 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EWC43928.1 - 0.026 14.5 0.0 0.069 13.1 0.0 1.7 1 1 0 1 1 1 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EWC43928.1 - 0.035 14.3 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 EWC43928.1 - 0.037 14.3 0.2 0.069 13.4 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 EWC43928.1 - 0.059 13.9 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EWC43928.1 - 0.064 12.3 0.1 0.096 11.7 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein 3Beta_HSD PF01073.19 EWC43928.1 - 0.15 11.1 0.2 0.21 10.5 0.2 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family MFS_1 PF07690.16 EWC43929.1 - 3.3e-29 101.9 23.9 5.4e-29 101.2 23.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily OAD_gamma PF04277.13 EWC43929.1 - 0.045 14.4 0.0 3.4 8.3 0.0 2.8 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF3372 PF11852.8 EWC43930.1 - 0.068 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) DUF3220 PF11516.8 EWC43930.1 - 0.07 13.4 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) DNA_ligase_A_M PF01068.21 EWC43931.1 - 0.095 12.3 0.1 0.11 12.1 0.1 1.0 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Hydrolase_4 PF12146.8 EWC43932.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 EWC43932.1 - 0.19 11.2 0.0 0.47 9.9 0.0 1.7 1 1 0 1 1 1 0 Putative serine esterase (DUF676) DUF3089 PF11288.8 EWC43932.1 - 0.2 11.2 0.0 0.39 10.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Proteasome PF00227.26 EWC43933.1 - 2e-50 171.0 0.0 7.1e-50 169.1 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EWC43933.1 - 6e-13 48.2 0.1 1.2e-12 47.2 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature RNase_J_C PF17770.1 EWC43933.1 - 0.17 12.9 0.1 0.44 11.6 0.1 1.7 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain HSA PF07529.13 EWC43934.1 - 1.7e-13 50.7 1.5 1.7e-13 50.7 1.5 4.0 5 0 0 5 5 5 1 HSA Myb_DNA-bind_6 PF13921.6 EWC43934.1 - 5.2e-08 33.0 2.4 1.1e-07 31.9 2.4 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EWC43934.1 - 3.5e-06 27.1 0.9 1.1e-05 25.5 0.9 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.32 EWC43935.1 - 5.2e-05 23.9 0.1 1.9 9.5 0.0 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat Glyco_hydro_61 PF03443.14 EWC43936.1 - 4.8e-37 127.9 0.2 9e-36 123.7 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 PAP1 PF08601.10 EWC43936.1 - 1.9 8.1 8.0 2.8 7.6 8.0 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 ABC_tran PF00005.27 EWC43937.1 - 9.5e-55 184.9 0.0 6.8e-29 101.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EWC43937.1 - 9.8e-25 87.4 42.6 1.1e-14 54.3 17.7 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EWC43937.1 - 2.7e-18 66.8 0.6 2.1e-06 27.8 0.0 4.4 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EWC43937.1 - 3.4e-08 33.2 0.9 0.0052 16.3 0.0 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EWC43937.1 - 8e-07 29.1 0.8 0.00099 19.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EWC43937.1 - 1.2e-06 29.2 0.4 0.069 13.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EWC43937.1 - 2e-06 28.3 0.2 0.012 16.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EWC43937.1 - 1.1e-05 25.1 0.3 0.016 14.9 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EWC43937.1 - 0.00014 21.6 3.0 0.22 11.2 0.1 3.0 2 2 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EWC43937.1 - 0.00046 20.0 0.0 2.4 7.8 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain Rad17 PF03215.15 EWC43937.1 - 0.00079 19.4 0.1 0.47 10.4 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 EWC43937.1 - 0.0024 18.1 1.3 1.5 9.1 0.0 3.3 2 2 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EWC43937.1 - 0.0035 17.1 1.6 14 5.4 0.1 4.3 5 0 0 5 5 5 0 IstB-like ATP binding protein AAA_19 PF13245.6 EWC43937.1 - 0.0054 17.1 0.8 1.4 9.2 0.2 2.6 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EWC43937.1 - 0.0057 16.3 0.1 1.1 8.9 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 EWC43937.1 - 0.0082 15.2 0.1 1.7 7.6 0.0 2.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_24 PF13479.6 EWC43937.1 - 0.0091 15.7 0.1 3.5 7.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EWC43937.1 - 0.03 14.5 0.1 6.6 7.0 0.0 4.1 3 2 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 EWC43937.1 - 0.03 13.8 0.4 2.3 7.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF4162 PF13732.6 EWC43937.1 - 0.036 14.8 0.0 5.8 7.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_27 PF13514.6 EWC43937.1 - 0.038 13.6 0.1 3.1 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EWC43937.1 - 0.039 14.4 1.8 13 6.2 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MukB PF04310.12 EWC43937.1 - 0.073 12.9 0.6 0.89 9.3 0.0 2.2 2 0 0 2 2 2 0 MukB N-terminal AAA_28 PF13521.6 EWC43937.1 - 0.22 11.8 1.2 25 5.0 0.9 2.4 2 0 0 2 2 2 0 AAA domain Tyrosinase PF00264.20 EWC43938.1 - 5.9e-50 170.6 2.2 5.9e-50 170.6 2.2 2.4 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EWC43938.1 - 1.5e-29 103.2 0.0 3.9e-29 101.8 0.0 1.8 1 0 0 1 1 1 1 Tyosinase C-terminal domain SOG2 PF10428.9 EWC43938.1 - 0.037 13.2 20.4 0.063 12.5 20.4 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 EWC43938.1 - 0.12 11.2 7.4 0.18 10.7 7.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4551 PF15087.6 EWC43938.1 - 0.51 9.1 7.2 0.83 8.4 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SPX PF03105.19 EWC43938.1 - 0.58 10.0 7.5 0.93 9.3 7.5 1.5 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 EWC43938.1 - 4.5 5.7 9.8 6.3 5.2 9.8 1.1 1 0 0 1 1 1 0 Macoilin family Churchill PF06573.11 EWC43940.1 - 0.29 11.5 1.1 0.43 10.9 1.1 1.2 1 0 0 1 1 1 0 Churchill protein DUF4134 PF13572.6 EWC43941.1 - 0.1 12.9 1.2 0.19 12.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) AA_permease_2 PF13520.6 EWC43942.1 - 1.2e-80 271.4 26.8 1.6e-80 271.1 26.8 1.0 1 0 0 1 1 1 1 Amino acid permease Gram_pos_anchor PF00746.21 EWC43942.1 - 6 6.9 6.4 3.1 7.8 0.0 3.3 3 0 0 3 3 3 0 LPXTG cell wall anchor motif PTR2 PF00854.21 EWC43945.1 - 1.3e-89 300.8 15.7 1.8e-89 300.3 15.7 1.1 1 0 0 1 1 1 1 POT family DUF5373 PF17343.2 EWC43945.1 - 0.011 15.6 0.3 0.011 15.6 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5373) CorA PF01544.18 EWC43946.1 - 5.2e-08 32.5 0.5 9.9e-08 31.6 0.5 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein LapA_dom PF06305.11 EWC43947.1 - 0.018 14.8 1.4 0.33 10.8 0.3 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Pkinase PF00069.25 EWC43948.1 - 3.2e-27 95.5 0.0 3.7e-26 92.1 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC43948.1 - 2.1e-09 37.0 0.0 1.6e-07 30.9 0.0 2.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC43948.1 - 0.0013 18.7 0.1 0.3 11.0 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EWC43948.1 - 0.0048 16.3 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Zn_protease PF05618.11 EWC43948.1 - 0.11 12.4 0.0 0.65 9.9 0.0 2.0 2 0 0 2 2 2 0 Putative ATP-dependant zinc protease Kinase-like PF14531.6 EWC43948.1 - 0.2 11.0 0.1 2.6 7.3 0.0 2.5 3 0 0 3 3 3 0 Kinase-like Sarcoglycan_2 PF05510.13 EWC43949.1 - 0.0019 17.0 0.0 0.0022 16.8 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon EphA2_TM PF14575.6 EWC43949.1 - 0.056 14.3 0.0 0.075 13.9 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Cytochrome-c551 PF10643.9 EWC43949.1 - 0.067 12.8 0.0 0.076 12.6 0.0 1.1 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 DUF2663 PF10864.8 EWC43949.1 - 0.14 12.6 0.0 0.19 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Amnionless PF14828.6 EWC43949.1 - 0.14 10.9 0.0 0.14 10.9 0.0 1.0 1 0 0 1 1 1 0 Amnionless BatD PF13584.6 EWC43949.1 - 0.14 10.9 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance DUF2627 PF11118.8 EWC43950.1 - 0.089 13.4 0.1 0.12 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) Syndecan PF01034.20 EWC43950.1 - 0.24 11.3 0.9 0.47 10.4 0.9 1.4 1 0 0 1 1 1 0 Syndecan domain PhyH PF05721.13 EWC43951.1 - 9e-10 39.2 0.0 1.5e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) CFEM PF05730.11 EWC43952.1 - 1e-11 44.7 8.8 1e-11 44.7 8.8 1.6 2 0 0 2 2 2 1 CFEM domain SOG2 PF10428.9 EWC43952.1 - 2 7.5 9.0 2.2 7.4 9.0 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein RP-C_C PF11800.8 EWC43952.1 - 2.2 8.3 6.3 13 5.9 6.4 1.8 1 1 0 1 1 1 0 Replication protein C C-terminal region FMN_red PF03358.15 EWC43955.1 - 8.7e-22 77.5 0.0 1.2e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EWC43955.1 - 0.00047 19.9 0.0 0.00068 19.4 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold DUF685 PF05085.12 EWC43955.1 - 0.0039 16.5 0.2 2.5 7.3 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF685) CCB2_CCB4 PF11152.8 EWC43955.1 - 0.099 11.9 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 F-box-like PF12937.7 EWC43956.1 - 9e-05 22.3 1.1 0.00041 20.2 1.1 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC43956.1 - 0.0037 17.1 0.1 0.011 15.6 0.1 1.8 1 0 0 1 1 1 1 F-box domain Aldo_ket_red PF00248.21 EWC43957.1 - 4.1e-44 150.9 0.0 7.8e-42 143.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family UBD PF16455.5 EWC43958.1 - 9.4e-31 106.2 0.0 1.7e-30 105.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-binding domain WD40 PF00400.32 EWC43959.1 - 4.3e-19 68.5 24.3 0.00047 20.9 0.9 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC43959.1 - 6.8e-10 39.1 6.2 0.0039 17.5 0.1 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 EWC43959.1 - 0.16 9.9 1.8 2 6.3 0.0 2.0 2 0 0 2 2 2 0 IKI3 family Sugar_tr PF00083.24 EWC43960.1 - 6.2e-30 104.4 34.7 1.1e-17 64.1 14.9 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EWC43960.1 - 9.2e-19 67.6 40.8 1.2e-11 44.1 22.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RNB PF00773.19 EWC43961.1 - 8.1e-89 298.2 0.1 1.4e-88 297.4 0.1 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 EWC43961.1 - 5.8e-27 94.2 0.5 2e-26 92.5 0.5 1.9 1 1 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EWC43961.1 - 4.6e-21 74.6 2.3 1.1e-20 73.3 2.3 1.6 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 EWC43961.1 - 1.6e-20 72.9 0.0 4.4e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EWC43961.1 - 3.2e-11 43.6 0.1 8.7e-11 42.2 0.1 1.8 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 EWC43961.1 - 7e-05 22.9 0.0 0.017 15.3 0.0 2.9 2 0 0 2 2 2 1 Cold shock domain OB_RNB PF08206.11 EWC43961.1 - 0.044 13.5 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Ribonuclease B OB domain CRC_subunit PF08624.10 EWC43962.1 - 1.5e-53 180.9 0.1 2.5e-53 180.1 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit zf-C2H2_3 PF13878.6 EWC43963.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO RNase_H PF00075.24 EWC43964.1 - 0.011 15.9 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 RNase H UPF0029 PF01205.19 EWC43965.1 - 4.7e-22 78.3 1.3 1.3e-21 76.9 0.0 2.3 2 1 1 3 3 3 1 Uncharacterized protein family UPF0029 Amidinotransf PF02274.17 EWC43965.1 - 0.14 11.3 0.4 0.18 10.8 0.4 1.2 1 0 0 1 1 1 0 Amidinotransferase GN3L_Grn1 PF08701.11 EWC43966.1 - 1.1e-25 89.5 14.5 2.4e-25 88.4 14.5 1.5 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EWC43966.1 - 4.7e-15 55.7 0.0 8.6e-12 45.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EWC43966.1 - 3.5e-06 27.0 0.2 4.6e-05 23.4 0.2 2.3 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EWC43966.1 - 3.2e-05 23.5 0.3 0.00018 21.1 0.1 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EWC43966.1 - 0.00014 21.5 0.1 0.018 14.6 0.0 2.8 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EWC43966.1 - 0.00029 21.0 1.2 0.085 12.9 0.2 3.4 2 1 1 3 3 3 1 Dynamin family AIG1 PF04548.16 EWC43966.1 - 0.0048 16.3 0.0 0.049 13.0 0.0 2.2 2 0 0 2 2 2 1 AIG1 family cobW PF02492.19 EWC43966.1 - 0.024 14.2 0.1 3.4 7.2 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EWC43966.1 - 0.039 12.9 0.1 0.08 11.9 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 EWC43966.1 - 0.042 14.1 0.0 2.3 8.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Torsin PF06309.11 EWC43966.1 - 0.091 12.9 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 Torsin HicB PF05534.12 EWC43966.1 - 0.17 11.8 0.7 0.44 10.4 0.4 1.8 2 0 0 2 2 2 0 HicB family FlgM PF04316.13 EWC43967.1 - 0.0063 16.8 0.0 0.014 15.7 0.0 1.7 1 1 0 1 1 1 1 Anti-sigma-28 factor, FlgM DUF5345 PF17280.2 EWC43967.1 - 0.009 16.0 0.4 0.009 16.0 0.4 1.9 2 0 0 2 2 2 1 Family of unknown function (DUF5345) Dor1 PF04124.12 EWC43967.1 - 0.012 14.3 2.5 0.015 14.0 2.5 1.1 1 0 0 1 1 1 0 Dor1-like family DUF1664 PF07889.12 EWC43967.1 - 0.021 14.9 1.2 0.035 14.1 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CysG_dimeriser PF10414.9 EWC43967.1 - 0.022 14.5 1.1 1.8 8.3 0.3 2.4 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region T2SSF PF00482.23 EWC43967.1 - 0.026 14.5 0.8 0.083 12.8 0.8 1.8 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F Tropomyosin_1 PF12718.7 EWC43967.1 - 0.036 14.2 11.7 1.3 9.2 8.0 2.1 1 1 1 2 2 2 0 Tropomyosin like Borrelia_orfA PF02414.15 EWC43967.1 - 0.067 12.8 1.1 0.096 12.3 1.1 1.2 1 0 0 1 1 1 0 Borrelia ORF-A GvpL_GvpF PF06386.11 EWC43967.1 - 0.077 12.9 2.8 0.12 12.2 2.8 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Exonuc_VII_L PF02601.15 EWC43967.1 - 0.41 10.2 3.4 0.51 9.9 3.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FadA PF09403.10 EWC43967.1 - 0.64 10.5 8.7 12 6.5 8.2 2.5 1 1 1 2 2 2 0 Adhesion protein FadA Synaptobrevin PF00957.21 EWC43967.1 - 1.1 9.1 4.5 4.6 7.1 0.1 3.0 1 1 1 2 2 2 0 Synaptobrevin GAS PF13851.6 EWC43967.1 - 1.1 8.6 10.3 4.6 6.5 10.3 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 EWC43967.1 - 1.6 8.8 9.6 2.6 8.1 9.5 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Homeodomain PF00046.29 EWC43968.1 - 1.8e-15 56.5 2.9 1.8e-15 56.5 2.9 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 EWC43968.1 - 0.00039 20.3 0.9 0.0012 18.7 0.9 1.9 1 0 0 1 1 1 1 Homeobox KN domain MRP-L20 PF12824.7 EWC43968.1 - 0.011 15.9 0.5 0.033 14.4 0.5 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 SelP_N PF04592.14 EWC43968.1 - 8 5.8 10.4 0.63 9.4 5.2 1.7 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Ank_4 PF13637.6 EWC43969.1 - 1.3e-36 124.5 7.1 3.6e-09 37.0 0.0 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EWC43969.1 - 8.5e-35 119.2 1.5 1e-15 58.0 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EWC43969.1 - 2.5e-30 101.1 0.1 0.00026 21.2 0.0 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 EWC43969.1 - 4.3e-27 93.8 0.2 4.1e-08 33.3 0.1 4.6 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EWC43969.1 - 1.3e-25 88.6 5.4 7.5e-05 23.0 0.1 6.2 6 0 0 6 6 6 6 Ankyrin repeat Shal-type PF11601.8 EWC43969.1 - 0.034 13.7 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 Shal-type voltage-gated potassium channels, N-terminal ERAP1_C PF11838.8 EWC43969.1 - 0.093 12.3 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 ERAP1-like C-terminal domain Prefoldin_2 PF01920.20 EWC43970.1 - 1e-19 70.4 6.4 1.1e-19 70.4 5.9 1.3 1 1 0 1 1 1 1 Prefoldin subunit XhlA PF10779.9 EWC43970.1 - 0.36 11.1 4.9 0.16 12.2 0.9 2.1 2 0 0 2 2 2 0 Haemolysin XhlA Jnk-SapK_ap_N PF09744.9 EWC43970.1 - 0.47 10.7 9.6 3.8 7.7 9.6 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Gryzun PF07919.12 EWC43972.1 - 2.6e-138 462.4 0.0 3.3e-138 462.1 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 EWC43972.1 - 4.4e-42 144.4 3.3 1.5e-38 132.9 2.1 2.8 2 1 0 2 2 2 2 Foie gras liver health family 1 TPR_12 PF13424.6 EWC43972.1 - 0.054 13.8 0.4 5.3 7.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat RXT2_N PF08595.11 EWC43973.1 - 5e-41 140.3 0.2 5e-41 140.3 0.2 2.3 2 0 0 2 2 2 1 RXT2-like, N-terminal Tubulin PF00091.25 EWC43974.1 - 1.5e-68 230.9 0.0 2.8e-68 230.0 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EWC43974.1 - 3.2e-43 146.9 0.0 5.2e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EWC43974.1 - 6.9e-05 23.1 0.0 0.00015 22.0 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EWC43974.1 - 0.0039 16.9 0.0 0.0072 16.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EWC43974.1 - 0.009 15.2 0.0 0.024 13.8 0.0 1.6 2 0 0 2 2 2 1 Tubulin like Arginosuc_synth PF00764.19 EWC43975.1 - 3.2e-157 523.8 0.0 3.7e-157 523.6 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EWC43975.1 - 0.0012 18.3 0.0 0.0022 17.5 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EWC43975.1 - 0.011 14.5 0.0 0.019 13.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase Apq12 PF12716.7 EWC43976.1 - 0.014 15.3 8.6 0.027 14.4 8.6 1.4 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis SelK_SelG PF10961.8 EWC43976.1 - 0.93 10.2 7.3 0.78 10.4 3.1 2.2 1 1 1 2 2 2 0 Selenoprotein SelK_SelG TMF_TATA_bd PF12325.8 EWC43977.1 - 7.6e-36 122.8 10.2 7.6e-36 122.8 10.2 6.8 4 1 3 7 7 7 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EWC43977.1 - 5.1e-15 55.2 19.0 5.1e-15 55.2 19.0 8.3 7 2 2 9 9 9 2 TATA element modulatory factor 1 DNA binding MbeD_MobD PF04899.12 EWC43977.1 - 7.4 6.8 15.4 0.041 14.0 1.5 4.1 5 0 0 5 5 5 0 MbeD/MobD like Ceramidase PF05875.12 EWC43978.1 - 4.4e-91 304.9 18.0 5.1e-91 304.7 18.0 1.0 1 0 0 1 1 1 1 Ceramidase DUF3397 PF11877.8 EWC43978.1 - 0.013 15.7 0.8 0.013 15.7 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3397) TauE PF01925.19 EWC43978.1 - 0.049 13.3 6.7 0.097 12.3 6.7 1.4 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE DUF2157 PF09925.9 EWC43978.1 - 0.15 11.8 5.4 0.27 11.0 5.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Peptidase_M28 PF04389.17 EWC43980.1 - 4.4e-32 111.4 0.0 7.6e-32 110.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EWC43980.1 - 1.9e-05 24.5 0.2 3.6e-05 23.6 0.2 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 3A PF00803.18 EWC43980.1 - 0.0078 15.5 0.0 0.1 11.9 0.0 2.0 2 0 0 2 2 2 1 3A/RNA2 movement protein family FixO PF02433.15 EWC43980.1 - 0.14 11.6 0.1 0.21 11.0 0.1 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO PEMT PF04191.13 EWC43982.1 - 8.7e-33 112.9 2.5 1.7e-32 111.9 2.5 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase WD40 PF00400.32 EWC43983.1 - 6.2e-38 128.1 7.6 1.5e-07 32.0 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 EWC43983.1 - 0.24 10.0 1.8 54 2.2 0.0 3.6 1 1 3 4 4 4 0 Nucleoporin Nup120/160 Prefoldin PF02996.17 EWC43984.1 - 2.3e-29 101.7 0.5 3.7e-29 101.1 0.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit DUF1192 PF06698.11 EWC43984.1 - 0.0014 18.7 0.3 0.0058 16.7 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) DUF1664 PF07889.12 EWC43984.1 - 0.0043 17.1 2.5 0.13 12.3 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Med30 PF11315.8 EWC43984.1 - 0.0066 16.6 1.0 0.34 11.1 0.1 2.1 2 0 0 2 2 2 1 Mediator complex subunit 30 Fib_alpha PF08702.10 EWC43984.1 - 0.0069 16.6 1.4 0.3 11.3 1.4 2.1 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family NMT1_3 PF16868.5 EWC43984.1 - 0.017 14.6 0.1 0.41 10.0 0.0 2.1 2 0 0 2 2 2 0 NMT1-like family FadA PF09403.10 EWC43984.1 - 0.026 15.0 2.8 3.1 8.3 0.3 2.1 2 0 0 2 2 2 0 Adhesion protein FadA Med10 PF09748.9 EWC43984.1 - 0.035 14.1 0.7 1.8 8.6 0.1 2.3 1 1 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex GIT_CC PF16559.5 EWC43984.1 - 0.052 13.4 1.5 0.093 12.6 1.5 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Prefoldin_2 PF01920.20 EWC43984.1 - 0.073 13.0 3.5 0.71 9.9 0.5 2.1 2 0 0 2 2 2 0 Prefoldin subunit Rep_1 PF01446.17 EWC43984.1 - 0.093 12.2 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 Replication protein Cep57_MT_bd PF06657.13 EWC43984.1 - 0.13 12.8 0.9 0.17 12.3 0.2 1.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Tektin PF03148.14 EWC43984.1 - 0.32 9.7 3.3 1.8 7.3 0.4 2.0 2 0 0 2 2 2 0 Tektin family KH_1 PF00013.29 EWC43985.1 - 1.3e-10 41.0 0.0 5.4e-06 26.1 0.0 2.7 2 0 0 2 2 2 2 KH domain AAA PF00004.29 EWC43986.1 - 1.2e-14 54.9 0.0 2.1e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC43986.1 - 1.4e-11 45.1 0.0 1.5e-10 41.7 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_lid_10 PF17872.1 EWC43986.1 - 3.3e-09 36.8 0.0 1.1e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_22 PF13401.6 EWC43986.1 - 2.9e-08 34.1 0.0 7.6e-07 29.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain BAH PF01426.18 EWC43986.1 - 2.2e-05 24.3 0.0 6.9e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 BAH domain AAA_19 PF13245.6 EWC43986.1 - 0.0013 19.1 0.0 0.0033 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain ssDBP PF17878.1 EWC43986.1 - 0.019 15.2 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 Single-stranded DNA-binding protein AAA_11 PF13086.6 EWC43986.1 - 0.03 14.1 0.0 0.073 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 EWC43986.1 - 0.037 13.2 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase ATPase_2 PF01637.18 EWC43986.1 - 0.048 13.6 0.0 0.85 9.5 0.0 2.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TFIIF_alpha PF05793.12 EWC43986.1 - 0.089 11.4 5.0 0.24 10.0 5.0 1.7 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_30 PF13604.6 EWC43986.1 - 0.098 12.4 0.1 0.22 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EWC43986.1 - 0.11 12.9 0.0 0.45 10.9 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 EWC43986.1 - 0.13 12.5 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EWC43986.1 - 0.19 11.2 0.0 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region YL1 PF05764.13 EWC43986.1 - 0.34 11.0 5.6 0.054 13.6 1.7 1.5 2 0 0 2 2 2 0 YL1 nuclear protein LZ_Tnp_IS66 PF13007.7 EWC43986.1 - 7.7 7.4 7.3 6.9 7.5 2.1 3.2 3 0 0 3 3 3 0 Transposase C of IS166 homeodomain 4HBT PF03061.22 EWC43987.1 - 6.9e-06 26.3 0.0 1.7e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily Isochorismatase PF00857.20 EWC43988.1 - 4.1e-16 59.6 0.0 6.5e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family Cation_ATPase_C PF00689.21 EWC43989.1 - 4e-44 150.5 8.3 4e-44 150.5 8.3 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EWC43989.1 - 7.2e-33 113.6 1.6 7.2e-33 113.6 1.6 2.6 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EWC43989.1 - 8e-20 70.7 0.0 1.6e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EWC43989.1 - 2.8e-18 67.0 0.1 8.2e-18 65.4 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EWC43989.1 - 1.7e-06 27.6 2.2 2.2e-06 27.2 0.1 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EWC43989.1 - 1.8e-05 24.6 0.5 0.00023 21.0 0.6 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RskA PF10099.9 EWC43989.1 - 0.00049 20.4 3.1 1.7 8.9 0.0 4.2 3 1 0 3 3 3 2 Anti-sigma-K factor rskA DUF3429 PF11911.8 EWC43989.1 - 0.048 13.9 2.9 1.6 9.0 0.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3429) tRNA-synt_2 PF00152.20 EWC43990.1 - 6.7e-75 252.1 0.0 1.1e-74 251.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EWC43990.1 - 1.2e-17 63.9 0.0 1.7e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 EWC43990.1 - 0.00093 19.1 0.1 0.0018 18.2 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EWC43990.1 - 0.022 14.3 0.4 2.1 7.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) DUF2396 PF09654.10 EWC43990.1 - 0.34 11.0 4.1 0.39 10.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2396) Ion_trans PF00520.31 EWC43991.1 - 1.2e-128 427.5 84.4 8.8e-38 129.9 13.2 4.8 4 1 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 EWC43991.1 - 0.00066 18.5 5.6 0.00066 18.5 5.6 6.6 6 2 2 8 8 8 3 Polycystin cation channel GPHH PF16905.5 EWC43991.1 - 0.003 17.3 0.0 0.0091 15.7 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated SET PF00856.28 EWC43993.1 - 1.9e-20 73.9 0.0 6.8e-20 72.1 0.0 1.9 2 0 0 2 2 2 1 SET domain Pre-SET PF05033.16 EWC43993.1 - 1.1e-16 61.4 3.9 1.1e-16 61.4 3.9 2.2 2 0 0 2 2 2 1 Pre-SET motif Chromo PF00385.24 EWC43993.1 - 7.4e-14 51.4 1.8 1.3e-13 50.6 1.8 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 EWC43993.1 - 0.016 15.0 0.1 0.033 14.1 0.1 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain AT_hook PF02178.19 EWC43993.1 - 0.066 13.1 17.6 0.16 12.0 4.1 3.0 3 0 0 3 3 3 0 AT hook motif APP_amyloid PF10515.9 EWC43993.1 - 0.16 12.5 0.0 0.43 11.1 0.0 1.7 1 0 0 1 1 1 0 Beta-amyloid precursor protein C-terminus Chromo_shadow PF01393.19 EWC43993.1 - 0.47 10.6 1.7 5.1 7.3 0.1 2.6 2 0 0 2 2 2 0 Chromo shadow domain Cys_rich_CWC PF14375.6 EWC43993.1 - 3.2 8.2 17.6 0.47 10.9 13.2 1.9 2 0 0 2 2 2 0 Cysteine-rich CWC Nop52 PF05997.12 EWC43994.1 - 4.5e-76 255.4 0.1 5.6e-76 255.1 0.1 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 SDA1 PF05285.12 EWC43994.1 - 0.38 10.1 5.7 11 5.4 0.0 2.1 2 0 0 2 2 2 0 SDA1 DAGK_cat PF00781.24 EWC43995.1 - 8.2e-24 83.6 0.0 1.3e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Adaptin_N PF01602.20 EWC43996.1 - 4.1e-94 316.0 4.2 6.7e-94 315.3 4.2 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EWC43996.1 - 3.8e-59 198.6 0.7 8.7e-59 197.4 0.7 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EWC43996.1 - 5.2e-55 184.9 0.0 1.6e-54 183.3 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EWC43996.1 - 2.1e-13 50.6 4.8 1.3e-10 41.6 0.1 2.8 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC43996.1 - 2.9e-09 37.2 2.2 0.0094 16.3 0.0 5.3 2 1 3 5 5 5 4 HEAT repeats HEAT PF02985.22 EWC43996.1 - 0.00035 20.6 1.8 1.2 9.6 0.0 5.2 6 0 0 6 6 6 1 HEAT repeat Stork_head PF10264.9 EWC43996.1 - 0.0083 16.3 0.0 0.13 12.4 0.1 2.5 2 0 0 2 2 2 1 Winged helix Storkhead-box1 domain AP4E_app_platf PF14807.6 EWC43996.1 - 0.026 14.9 0.1 0.1 13.0 0.1 2.1 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Mago_nashi PF02792.14 EWC43997.1 - 5.3e-73 243.8 0.2 5.9e-73 243.6 0.2 1.0 1 0 0 1 1 1 1 Mago nashi protein Vac_ImportDeg PF09783.9 EWC43998.1 - 1.7e-63 213.3 0.8 2.2e-63 212.9 0.8 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein Methyltransf_4 PF02390.17 EWC43999.1 - 1.7e-59 200.2 0.0 2.5e-59 199.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EWC43999.1 - 0.00033 21.3 0.0 0.002 18.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC43999.1 - 0.001 19.7 0.0 0.0076 17.0 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 EWC43999.1 - 0.0031 17.1 0.0 0.036 13.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 EWC43999.1 - 0.045 14.4 0.0 0.61 10.8 0.0 2.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EWC43999.1 - 0.087 12.6 0.0 0.13 12.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EWC43999.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EWC43999.1 - 0.14 11.4 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PXA PF02194.15 EWC44000.1 - 4.6e-46 157.1 0.5 1.1e-45 155.8 0.5 1.7 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 EWC44000.1 - 1.7e-21 76.9 2.0 2.9e-21 76.1 0.1 2.5 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 EWC44000.1 - 2.5e-20 72.6 0.1 8.3e-20 70.9 0.1 1.9 1 0 0 1 1 1 1 PX domain RGS PF00615.19 EWC44000.1 - 1.3e-12 48.0 0.0 4.5e-12 46.3 0.0 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain Rbsn PF11464.8 EWC44000.1 - 0.042 13.6 0.5 0.11 12.3 0.5 1.8 1 0 0 1 1 1 0 Rabenosyn Rab binding domain ABC_tran PF00005.27 EWC44001.1 - 1.5e-47 161.5 0.2 6.1e-23 81.9 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EWC44001.1 - 3.4e-21 75.1 2.4 3.4e-21 75.1 2.4 2.7 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 EWC44001.1 - 1.3e-15 58.0 12.2 0.00034 20.5 0.0 4.8 3 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EWC44001.1 - 5.7e-09 35.7 0.1 0.28 10.6 0.0 4.4 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EWC44001.1 - 2.5e-07 31.3 4.5 0.00091 19.8 0.0 3.4 5 0 0 5 5 2 2 AAA domain AAA_22 PF13401.6 EWC44001.1 - 3.5e-07 30.6 0.0 0.0078 16.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EWC44001.1 - 4.5e-07 30.6 12.4 0.012 16.1 0.0 4.7 5 0 0 5 5 5 2 AAA domain AAA_16 PF13191.6 EWC44001.1 - 3.5e-06 27.5 0.5 0.059 13.8 0.1 2.9 3 0 0 3 3 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EWC44001.1 - 6.8e-06 26.2 0.3 0.11 12.6 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EWC44001.1 - 9.6e-06 25.3 0.4 0.13 12.0 0.1 3.0 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EWC44001.1 - 1.2e-05 25.3 2.1 0.037 13.9 0.1 2.7 2 1 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EWC44001.1 - 1.9e-05 24.5 0.2 0.41 10.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 EWC44001.1 - 8e-05 22.9 0.1 0.36 11.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EWC44001.1 - 0.00013 22.1 0.4 0.92 9.7 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 EWC44001.1 - 0.00047 20.0 10.3 0.33 10.6 0.0 4.2 4 1 0 4 4 4 2 AAA ATPase domain AAA PF00004.29 EWC44001.1 - 0.00084 19.8 0.0 1.7 9.1 0.0 3.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_27 PF13514.6 EWC44001.1 - 0.0012 18.5 1.0 4.9 6.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 EWC44001.1 - 0.0025 17.9 0.0 1.8 8.6 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EWC44001.1 - 0.0031 17.3 0.7 0.71 9.6 0.6 3.4 3 1 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EWC44001.1 - 0.0032 16.8 2.2 1.7 7.8 0.2 3.4 3 0 0 3 3 3 1 Zeta toxin NACHT PF05729.12 EWC44001.1 - 0.0055 16.6 0.9 0.87 9.5 0.0 2.7 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EWC44001.1 - 0.0062 16.9 0.0 5.8 7.4 0.0 2.7 2 0 0 2 2 2 0 RNA helicase cobW PF02492.19 EWC44001.1 - 0.01 15.5 0.6 1.8 8.2 0.3 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EWC44001.1 - 0.017 14.6 0.1 5.7 6.4 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EWC44001.1 - 0.019 15.0 0.5 3.4 7.7 0.0 3.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Roc PF08477.13 EWC44001.1 - 0.019 15.2 0.1 4.1 7.6 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 EWC44001.1 - 0.019 14.6 0.0 0.4 10.3 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.15 EWC44001.1 - 0.025 14.5 0.4 1.9 8.4 0.0 2.7 2 1 0 2 2 2 0 Rad17 P-loop domain MeaB PF03308.16 EWC44001.1 - 0.028 13.4 3.3 1.1 8.1 0.1 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EWC44001.1 - 0.031 14.2 0.2 2.7 7.9 0.2 2.6 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 EWC44001.1 - 0.041 13.6 0.1 7 6.4 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 EWC44001.1 - 0.095 12.2 0.1 1.6 8.2 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family FeoB_N PF02421.18 EWC44001.1 - 0.098 12.2 0.2 10 5.6 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B SbcCD_C PF13558.6 EWC44001.1 - 0.13 12.5 0.6 6.7 7.0 0.2 3.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.6 EWC44001.1 - 0.17 12.3 4.1 27 5.2 0.2 3.7 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 EWC44001.1 - 0.56 10.2 8.6 7.9 6.5 0.0 4.2 4 1 1 5 5 4 0 Dynamin family TraF_2 PF13729.6 EWC44002.1 - 0.1 11.9 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein Vps26 PF03643.15 EWC44006.1 - 9.9e-126 418.3 0.7 1.1e-125 418.1 0.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EWC44006.1 - 0.0021 18.1 0.4 0.48 10.5 0.1 3.1 2 1 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain SKI PF01202.22 EWC44007.1 - 2.4e-11 44.0 0.0 3.3e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 EWC44007.1 - 6e-09 36.2 0.0 1e-08 35.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EWC44007.1 - 4.7e-08 33.7 0.0 9.2e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EWC44007.1 - 7.1e-05 22.6 0.0 0.00025 20.9 0.0 1.7 1 1 0 1 1 1 1 Cytidylate kinase AAA_17 PF13207.6 EWC44007.1 - 0.00052 20.4 0.2 0.0017 18.8 0.0 1.9 2 1 0 2 2 1 1 AAA domain dNK PF01712.19 EWC44007.1 - 0.00078 19.3 0.0 0.37 10.6 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_16 PF13191.6 EWC44007.1 - 0.002 18.5 0.0 0.0028 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EWC44007.1 - 0.0035 17.6 0.0 0.0069 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EWC44007.1 - 0.0053 17.2 0.0 0.013 15.9 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EWC44007.1 - 0.0066 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain Ploopntkinase1 PF18748.1 EWC44007.1 - 0.0068 15.9 0.0 0.22 11.0 0.0 2.1 2 0 0 2 2 2 1 P-loop Nucleotide Kinase1 APS_kinase PF01583.20 EWC44007.1 - 0.0091 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase RNA_helicase PF00910.22 EWC44007.1 - 0.0099 16.3 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA helicase CoaE PF01121.20 EWC44007.1 - 0.027 14.2 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Dephospho-CoA kinase Zeta_toxin PF06414.12 EWC44007.1 - 0.039 13.2 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 EWC44007.1 - 0.052 13.1 0.1 0.33 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EWC44007.1 - 0.088 13.3 0.0 0.11 13.0 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 EWC44007.1 - 0.095 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 EWC44007.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EWC44007.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain PRK PF00485.18 EWC44007.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 EWC44007.1 - 0.15 12.0 0.0 0.4 10.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EWC44007.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Herpes_Helicase PF02689.14 EWC44007.1 - 0.17 9.8 0.0 0.22 9.4 0.0 1.1 1 0 0 1 1 1 0 Helicase 2-oxoacid_dh PF00198.23 EWC44008.1 - 2.1e-74 249.9 0.1 3.3e-74 249.3 0.1 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EWC44008.1 - 5.7e-20 70.9 0.0 1.1e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EWC44008.1 - 6e-15 55.3 0.4 1.4e-14 54.1 0.4 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EWC44008.1 - 0.021 14.7 0.3 0.077 12.8 0.0 2.1 3 0 0 3 3 3 0 Biotin-lipoyl like bZIP_2 PF07716.15 EWC44010.1 - 5.2e-07 29.6 5.0 1.2e-06 28.5 5.0 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EWC44010.1 - 1.4e-06 28.2 6.8 3e-06 27.2 6.8 1.5 1 0 0 1 1 1 1 bZIP transcription factor DUF4529 PF15032.6 EWC44010.1 - 0.015 14.5 1.4 0.025 13.7 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4529) bZIP_Maf PF03131.17 EWC44010.1 - 0.05 14.1 3.7 0.11 13.0 3.7 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.15 EWC44010.1 - 0.9 9.4 4.8 1.7 8.5 4.8 1.3 1 0 0 1 1 1 0 Septum formation initiator Rcd1 PF04078.13 EWC44011.1 - 5.2e-127 422.5 3.0 8e-127 421.9 3.0 1.3 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like TFIIA PF03153.13 EWC44011.1 - 6e-07 29.8 43.9 8.1e-07 29.4 43.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 EWC44011.1 - 0.0045 17.2 8.4 0.0073 16.5 8.4 1.5 1 0 0 1 1 1 1 DDHD domain Ndc1_Nup PF09531.10 EWC44011.1 - 0.022 13.5 11.6 0.034 12.9 11.6 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 EWC44011.1 - 0.023 13.9 17.6 0.03 13.5 17.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein PAT1 PF09770.9 EWC44011.1 - 0.028 12.7 28.7 0.034 12.4 28.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Het-C PF07217.11 EWC44011.1 - 0.053 12.1 6.8 0.084 11.4 6.8 1.4 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Exonuc_VII_L PF02601.15 EWC44011.1 - 0.14 11.7 21.6 0.23 11.0 21.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit MMR1 PF08505.10 EWC44011.1 - 0.24 11.7 24.1 0.4 10.9 24.1 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Glyco_transf_41 PF13844.6 EWC44011.1 - 1.9 6.8 8.6 2.6 6.4 8.6 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 PNISR PF15996.5 EWC44011.1 - 3.3 7.9 24.3 5.4 7.2 24.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR V_ATPase_I PF01496.19 EWC44011.1 - 4 5.2 17.5 5.9 4.7 17.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 EWC44011.1 - 4.5 6.5 19.1 8.9 5.6 19.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.7 EWC44011.1 - 4.9 5.2 24.0 7.6 4.5 24.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 EWC44011.1 - 5.4 5.7 23.6 8.1 5.1 23.6 1.2 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 EWC44011.1 - 5.5 6.9 11.6 9.8 6.1 11.6 1.5 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 EWC44011.1 - 6.8 5.6 20.9 10 5.0 20.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TMEM43 PF07787.12 EWC44011.1 - 9.1 5.6 0.0 9.1 5.6 0.0 2.5 1 1 1 2 2 1 0 Transmembrane protein 43 AUX_IAA PF02309.16 EWC44011.1 - 9.3 6.0 11.0 16 5.2 11.0 1.5 1 0 0 1 1 1 0 AUX/IAA family Pkinase PF00069.25 EWC44012.1 - 1.7e-68 230.9 0.0 2.4e-68 230.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44012.1 - 5.7e-38 130.7 0.0 1e-37 129.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EWC44012.1 - 1.4e-17 63.2 0.1 2.5e-17 62.4 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 EWC44012.1 - 1.6e-05 24.0 0.0 3.2e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EWC44012.1 - 0.00016 21.1 0.0 0.00027 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EWC44012.1 - 0.0002 20.8 0.1 0.00042 19.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EWC44012.1 - 0.0024 17.8 0.0 0.012 15.6 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.11 EWC44012.1 - 0.035 13.7 0.1 0.055 13.1 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 EWC44012.1 - 0.047 13.3 0.0 0.091 12.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family PHD PF00628.29 EWC44013.1 - 2.9e-09 36.7 8.3 3e-09 36.6 6.6 2.0 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EWC44013.1 - 2.6e-05 23.7 2.2 2.6e-05 23.7 2.2 1.8 2 0 0 2 2 2 1 PHD-finger WHIM1 PF15612.6 EWC44013.1 - 0.00014 21.3 0.0 0.00034 20.1 0.0 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 CENP-N PF05238.13 EWC44013.1 - 0.48 9.7 8.7 0.25 10.6 6.7 1.5 2 0 0 2 2 2 0 Kinetochore protein CHL4 like HMG_box PF00505.19 EWC44014.1 - 8.1e-08 32.6 1.2 1.6e-07 31.6 0.2 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box Sld5 PF05916.11 EWC44015.1 - 5.6e-13 49.3 0.0 7.9e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Sulfate_transp PF00916.20 EWC44016.1 - 1.1e-62 212.0 20.4 3e-62 210.6 20.8 1.5 2 0 0 2 2 2 1 Sulfate permease family cNMP_binding PF00027.29 EWC44016.1 - 3.4e-16 59.1 0.0 7.1e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 EWC44016.1 - 7.9e-13 48.1 0.1 2e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 STAS domain PH_6 PF15406.6 EWC44017.1 - 2.4e-20 72.9 0.3 2.4e-20 72.9 0.3 3.3 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 EWC44017.1 - 0.0098 16.4 0.0 0.031 14.8 0.0 1.9 1 0 0 1 1 1 1 PH domain DEAD PF00270.29 EWC44019.1 - 1.3e-48 165.0 0.0 3.4e-48 163.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC44019.1 - 1.5e-25 89.7 0.0 5e-25 88.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC44019.1 - 0.0034 17.4 0.0 0.0081 16.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PTS_2-RNA PF01885.16 EWC44020.1 - 3.5e-63 212.9 0.0 4.1e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family TPP_enzyme_N PF02776.18 EWC44022.1 - 7.7e-33 113.5 0.0 1.8e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EWC44022.1 - 1.5e-16 60.4 0.0 3.5e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EWC44022.1 - 1e-15 57.8 0.0 2.6e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Man-6-P_recep PF02157.15 EWC44023.1 - 1.2e-12 47.5 0.0 2e-12 46.8 0.0 1.3 1 1 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EWC44023.1 - 1.3e-12 48.2 0.1 3.8e-12 46.6 0.1 1.6 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EWC44023.1 - 8.2e-11 42.2 0.0 2.1e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat ERG4_ERG24 PF01222.17 EWC44024.1 - 1.4e-135 452.4 7.8 1.5e-135 452.3 7.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EWC44024.1 - 7.8e-05 22.3 0.5 7.8e-05 22.3 0.5 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1295) Scs3p PF10261.9 EWC44025.1 - 1.2e-64 218.2 23.2 7.9e-62 209.0 23.2 2.1 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Methyltransf_23 PF13489.6 EWC44026.1 - 4.5e-10 39.6 0.0 6.4e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC44026.1 - 2.6e-06 28.0 0.0 7.9e-06 26.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44026.1 - 0.00014 21.7 0.0 0.00033 20.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC44026.1 - 0.00022 21.9 0.0 0.00056 20.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44026.1 - 0.0011 19.6 0.0 0.0083 16.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain CLU PF13236.6 EWC44027.1 - 3.4e-75 252.7 0.0 5.4e-75 252.0 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EWC44027.1 - 1.5e-50 171.7 0.0 3.6e-50 170.4 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EWC44027.1 - 2.5e-25 88.6 7.4 1.6e-12 47.5 0.3 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 EWC44027.1 - 3.6e-25 88.1 0.1 8.9e-25 86.9 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 EWC44027.1 - 9.7e-22 76.2 6.1 1.5e-06 27.8 0.1 5.4 5 1 1 6 6 6 3 Tetratricopeptide repeat DUF727 PF05303.12 EWC44027.1 - 1.5e-05 25.0 0.0 5e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_2 PF07719.17 EWC44027.1 - 0.00053 19.9 0.3 8.3 6.8 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EWC44027.1 - 0.001 19.1 0.5 2.4 8.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EWC44027.1 - 0.026 14.9 2.9 66 4.2 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EWC44027.1 - 0.052 13.4 0.5 7.2 6.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat GNAT_C PF18164.1 EWC44027.1 - 0.16 11.7 0.1 0.37 10.5 0.1 1.6 1 0 0 1 1 1 0 GNAT-like C-terminal domain AAA_16 PF13191.6 EWC44028.1 - 3.5e-07 30.7 0.3 3.3e-06 27.6 0.2 2.7 3 1 0 3 3 3 1 AAA ATPase domain ATPase_2 PF01637.18 EWC44028.1 - 3.2e-06 27.2 0.0 5.7e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EWC44028.1 - 0.016 14.9 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Forkhead PF00250.18 EWC44029.1 - 7.9e-35 119.0 0.1 1.4e-34 118.2 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EWC44029.1 - 1.8e-08 34.6 0.1 4.8e-08 33.2 0.0 1.8 2 0 0 2 2 2 1 FHA domain Fungal_trans PF04082.18 EWC44030.1 - 6.2e-23 81.2 0.0 1e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44030.1 - 3.6e-09 36.6 14.3 8.9e-09 35.3 14.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EWC44030.1 - 0.044 13.9 0.9 0.076 13.2 0.0 1.8 2 0 0 2 2 2 0 Gal4-like dimerisation domain Pkinase PF00069.25 EWC44031.1 - 7.7e-62 209.0 0.0 9.5e-62 208.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44031.1 - 4.8e-34 117.8 0.0 7e-34 117.3 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC44031.1 - 0.00015 20.7 0.0 0.00024 20.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EWC44031.1 - 0.0002 20.8 0.0 0.00083 18.8 0.0 1.7 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EWC44031.1 - 0.034 13.8 0.0 1.9 8.0 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 EWC44031.1 - 0.043 12.9 0.0 0.062 12.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.32 EWC44032.1 - 1.4e-22 79.6 15.2 1.1e-05 26.1 0.4 6.6 5 1 0 5 5 5 5 WD domain, G-beta repeat F-box-like PF12937.7 EWC44032.1 - 6.4e-11 42.0 0.6 1.3e-10 41.0 0.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC44032.1 - 2.9e-08 33.4 0.0 6.1e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EWC44032.1 - 6e-06 25.2 0.5 0.14 10.8 0.0 4.0 3 1 1 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EWC44032.1 - 0.0017 18.6 0.2 14 6.1 0.0 4.1 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EWC44032.1 - 0.057 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 F-box EB1 PF03271.17 EWC44033.1 - 1.4e-17 63.6 0.4 2.6e-17 62.8 0.4 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EWC44033.1 - 6.1e-08 32.8 0.2 9.8e-08 32.1 0.2 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain TPR_1 PF00515.28 EWC44034.1 - 1e-31 107.4 15.0 5.8e-06 25.9 0.3 8.1 6 1 2 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 EWC44034.1 - 8.8e-31 103.5 18.6 2.3e-05 24.2 0.1 8.5 6 1 2 8 8 8 6 Tetratricopeptide repeat DnaJ PF00226.31 EWC44034.1 - 4e-27 94.1 2.2 9.2e-27 93.0 2.2 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_11 PF13414.6 EWC44034.1 - 1.9e-20 72.2 14.0 2.3e-07 30.4 1.2 6.6 3 2 3 6 6 6 4 TPR repeat TPR_16 PF13432.6 EWC44034.1 - 3.5e-19 69.2 22.7 1.5e-05 25.5 0.7 6.3 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 EWC44034.1 - 5.4e-19 67.1 6.5 3.3e-05 24.0 0.2 6.0 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 EWC44034.1 - 1.5e-17 62.2 9.8 0.00071 19.6 0.4 7.7 7 1 3 10 10 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 EWC44034.1 - 3.3e-17 62.7 18.9 0.00034 21.1 1.1 5.9 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EWC44034.1 - 5.2e-14 51.7 23.6 0.0046 17.7 0.1 8.5 5 2 4 9 9 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 EWC44034.1 - 1.4e-11 44.4 8.3 5.3e-05 23.3 0.1 4.9 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EWC44034.1 - 3.8e-10 39.9 10.5 0.11 12.9 0.1 6.7 3 2 2 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC44034.1 - 2.9e-09 37.0 3.0 0.00022 21.4 0.0 3.7 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EWC44034.1 - 3.8e-06 26.5 6.2 1.3 9.2 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 EWC44034.1 - 2.4e-05 24.0 19.1 4.5 7.3 0.1 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EWC44034.1 - 0.0045 17.5 6.2 37 5.3 0.3 5.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 EWC44034.1 - 0.0085 16.4 16.1 1.7 9.0 0.1 5.2 4 2 0 5 5 5 1 Tetratricopeptide repeat BTAD PF03704.17 EWC44034.1 - 0.011 16.1 7.4 0.3 11.5 0.2 4.5 3 2 1 4 4 4 0 Bacterial transcriptional activator domain DUF928 PF06051.12 EWC44034.1 - 0.032 14.1 0.1 0.073 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Alkyl_sulf_dimr PF14863.6 EWC44034.1 - 0.038 14.5 4.7 9.8 6.6 0.6 4.2 2 2 0 2 2 2 0 Alkyl sulfatase dimerisation Fis1_TPR_C PF14853.6 EWC44034.1 - 0.11 12.6 4.8 4.8 7.3 0.0 4.8 5 1 1 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 EWC44034.1 - 3.1 8.7 13.0 62 4.7 0.0 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF4451 PF14616.6 EWC44035.1 - 3.4e-23 82.2 0.3 9.1e-23 80.8 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) BAR_3 PF16746.5 EWC44036.1 - 7.2e-17 61.9 0.6 1.4e-16 61.0 0.6 1.4 1 0 0 1 1 1 1 BAR domain of APPL family VASt PF16016.5 EWC44036.1 - 3.6e-14 53.4 0.0 7e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 EWC44036.1 - 2.3e-10 40.9 0.1 1.7e-09 38.2 0.1 2.4 2 0 0 2 2 2 1 PH domain GRAM PF02893.20 EWC44036.1 - 0.034 14.0 0.0 0.088 12.7 0.0 1.6 1 0 0 1 1 1 0 GRAM domain PX PF00787.24 EWC44037.1 - 5.8e-16 58.5 0.1 5.4e-15 55.4 0.0 2.1 2 0 0 2 2 2 1 PX domain Syntaxin-6_N PF09177.11 EWC44037.1 - 0.0043 17.6 0.9 0.74 10.4 0.1 2.9 2 0 0 2 2 2 2 Syntaxin 6, N-terminal Snapin_Pallidin PF14712.6 EWC44037.1 - 2.2 8.8 7.0 1.1 9.7 4.2 2.0 2 0 0 2 2 2 0 Snapin/Pallidin ING PF12998.7 EWC44038.1 - 0.00018 22.0 0.1 0.00079 20.0 0.0 2.0 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding RWP-RK PF02042.15 EWC44039.1 - 0.015 15.3 0.7 0.14 12.2 0.2 2.4 2 0 0 2 2 2 0 RWP-RK domain RNase_T PF00929.24 EWC44039.1 - 0.086 13.4 0.2 0.4 11.2 0.0 2.0 2 0 0 2 2 2 0 Exonuclease KH_1 PF00013.29 EWC44040.1 - 1.2e-42 143.5 7.2 3.5e-17 62.0 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EWC44040.1 - 3.8e-10 39.4 7.8 0.0056 16.5 0.3 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EWC44040.1 - 8.3e-09 35.2 1.4 0.052 13.4 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EWC44040.1 - 0.00038 20.5 6.1 0.29 11.3 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 EWC44040.1 - 0.04 13.9 0.0 16 5.6 0.0 2.6 3 0 0 3 3 3 0 KH-like RNA-binding domain PKI PF02827.16 EWC44040.1 - 0.079 13.2 1.2 0.17 12.1 1.2 1.6 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor Ku PF02735.16 EWC44041.1 - 5.7e-31 107.8 0.0 1.5e-30 106.5 0.0 1.6 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 EWC44041.1 - 7.6e-29 100.3 0.2 1.9e-28 99.0 0.2 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.15 EWC44041.1 - 3.3e-13 49.9 0.0 7.2e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA PF00092.28 EWC44041.1 - 0.0042 17.4 0.3 0.011 16.0 0.1 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EWC44041.1 - 0.03 15.0 0.0 0.12 13.0 0.0 2.1 1 1 0 1 1 1 0 von Willebrand factor type A domain NT-C2 PF10358.9 EWC44042.1 - 2.4e-31 108.4 0.0 3.4e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Abhydrolase_1 PF00561.20 EWC44043.1 - 4.4e-19 69.1 0.0 1.3e-18 67.6 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC44043.1 - 2.1e-16 60.0 0.1 6e-16 58.4 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EWC44043.1 - 1.3e-10 42.2 0.0 2.4e-10 41.4 0.0 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family BAAT_C PF08840.11 EWC44043.1 - 0.00018 21.5 0.2 0.0027 17.7 0.2 2.1 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EWC44043.1 - 0.00054 19.6 0.1 0.052 13.1 0.1 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EWC44043.1 - 0.00083 19.2 0.0 0.15 11.9 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EWC44043.1 - 0.0031 17.0 0.2 2.5 7.5 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family PGAP1 PF07819.13 EWC44043.1 - 0.0041 16.9 0.0 0.027 14.2 0.0 2.0 2 0 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.20 EWC44043.1 - 0.0053 16.9 0.0 0.019 15.1 0.0 1.8 2 0 0 2 2 2 1 Thioesterase domain DUF1100 PF06500.11 EWC44043.1 - 0.0066 15.3 0.0 0.0087 14.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) UPF0227 PF05728.12 EWC44043.1 - 0.023 14.7 0.0 0.15 12.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Esterase_phd PF10503.9 EWC44043.1 - 0.071 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Esterase PHB depolymerase Esterase PF00756.20 EWC44043.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.4 1 1 0 1 1 1 0 Putative esterase FOP_dimer PF09398.10 EWC44043.1 - 0.16 12.3 0.0 7.5 6.9 0.0 2.4 2 0 0 2 2 2 0 FOP N terminal dimerisation domain FIST PF08495.10 EWC44043.1 - 0.16 12.0 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 FIST N domain PHD PF00628.29 EWC44044.1 - 1.8e-12 46.9 8.8 3.9e-12 45.9 8.8 1.6 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 EWC44044.1 - 0.23 11.6 4.0 0.55 10.4 4.0 1.7 1 0 0 1 1 1 0 PHD-finger Ribosomal_L24e PF01246.20 EWC44045.1 - 3.4e-06 27.2 0.8 8.4e-06 25.9 0.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e Peptidase_M41 PF01434.18 EWC44046.1 - 1.7e-67 227.0 0.0 2.5e-67 226.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EWC44046.1 - 1.3e-43 148.6 0.0 3e-43 147.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC44046.1 - 9.2e-11 41.4 0.1 1.9e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EWC44046.1 - 2.6e-08 34.2 0.0 6.8e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 EWC44046.1 - 0.00016 21.7 0.0 0.00055 19.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EWC44046.1 - 0.001 19.5 0.2 0.068 13.6 0.1 3.0 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EWC44046.1 - 0.0057 16.9 0.1 0.34 11.2 0.1 2.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EWC44046.1 - 0.0062 15.8 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 EWC44046.1 - 0.023 14.4 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EWC44046.1 - 0.056 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 EWC44046.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EWC44046.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF1295 PF06966.12 EWC44047.1 - 1.3e-33 116.4 9.2 1.8e-33 116.1 9.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) MBOAT PF03062.19 EWC44048.1 - 1.4e-37 129.9 27.8 1.5e-36 126.5 27.8 2.1 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EWC44048.1 - 0.00019 21.6 4.7 0.00066 19.9 4.7 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Pex14_N PF04695.13 EWC44048.1 - 0.053 14.2 0.0 12 6.6 0.0 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pal1 PF08316.11 EWC44049.1 - 9.6e-48 162.4 0.3 9.6e-48 162.4 0.3 2.4 2 0 0 2 2 2 1 Pal1 cell morphology protein TMEM171 PF15471.6 EWC44049.1 - 0.57 9.1 3.2 0.93 8.4 3.2 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 CDC45 PF02724.14 EWC44049.1 - 2.8 6.1 11.6 4.4 5.5 11.6 1.2 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 EWC44049.1 - 4.2 6.0 10.6 7.2 5.3 10.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Stm1_N PF09598.10 EWC44050.1 - 3.8e-13 50.1 0.8 3.8e-13 50.1 0.8 4.2 4 2 0 4 4 4 1 Stm1 HABP4_PAI-RBP1 PF04774.15 EWC44050.1 - 1.9e-09 38.4 12.7 1.9e-09 38.4 12.7 2.6 1 1 1 2 2 2 1 Hyaluronan / mRNA binding family LRR_6 PF13516.6 EWC44051.1 - 6e-16 57.1 34.0 0.025 14.6 0.0 13.6 14 0 0 14 14 14 5 Leucine Rich repeat F-box-like PF12937.7 EWC44051.1 - 5.7e-11 42.1 1.2 1.6e-10 40.7 1.2 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EWC44051.1 - 8.3e-11 42.0 31.6 0.044 14.2 1.3 8.7 7 2 4 11 11 11 7 Leucine Rich repeats (2 copies) Recep_L_domain PF01030.24 EWC44051.1 - 0.00044 20.3 4.6 0.32 11.1 0.2 4.2 3 1 1 4 4 4 1 Receptor L domain F-box PF00646.33 EWC44051.1 - 0.00047 20.0 0.3 0.0039 17.0 0.1 2.7 3 0 0 3 3 3 1 F-box domain LRR_2 PF07723.13 EWC44051.1 - 0.2 12.4 1.6 0.84 10.4 0.1 3.1 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_1 PF00560.33 EWC44051.1 - 0.22 12.2 24.1 17 6.4 0.0 9.6 10 3 0 10 10 10 0 Leucine Rich Repeat LRR_8 PF13855.6 EWC44051.1 - 1.6 8.5 25.4 0.034 13.9 1.1 6.7 6 2 2 8 8 8 0 Leucine rich repeat Adaptin_N PF01602.20 EWC44052.1 - 6.4e-142 473.8 3.6 8e-142 473.5 3.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EWC44052.1 - 7.2e-22 77.8 0.2 1.8e-21 76.5 0.2 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EWC44052.1 - 8.7e-12 45.4 5.5 9.6e-08 32.2 0.1 3.7 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC44052.1 - 1.4e-06 28.5 1.6 0.012 16.0 0.0 4.0 4 0 0 4 4 4 2 HEAT repeats DUF3730 PF12530.8 EWC44052.1 - 0.0026 17.4 0.0 0.096 12.2 0.0 2.4 1 1 0 2 2 2 1 Protein of unknown function (DUF3730) HEAT PF02985.22 EWC44052.1 - 0.012 15.9 3.1 19 5.8 0.1 4.7 4 0 0 4 4 4 0 HEAT repeat Dopey_N PF04118.14 EWC44052.1 - 0.036 13.2 0.1 0.073 12.2 0.1 1.5 1 0 0 1 1 1 0 Dopey, N-terminal RICTOR_M PF14666.6 EWC44052.1 - 0.13 12.0 0.0 0.66 9.8 0.0 2.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain Arm PF00514.23 EWC44052.1 - 0.13 12.3 0.0 99 3.2 0.1 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 EWC44052.1 - 6.8 5.9 7.6 8.3 5.6 0.7 3.4 2 1 1 3 3 3 0 V-ATPase subunit H Topoisom_bac PF01131.20 EWC44053.1 - 5.4e-101 338.6 0.0 4.8e-95 319.0 0.0 2.1 2 0 0 2 2 2 2 DNA topoisomerase Toprim PF01751.22 EWC44053.1 - 9.1e-17 61.2 0.0 1.8e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Toprim domain DUF3535 PF12054.8 EWC44054.1 - 1.9e-129 432.7 0.0 7e-127 424.3 0.0 3.3 5 0 0 5 5 5 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EWC44054.1 - 3.3e-68 230.0 0.1 7.2e-68 228.8 0.1 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.22 EWC44054.1 - 6.8e-18 63.2 8.7 0.01 16.0 0.0 8.1 8 0 0 8 8 8 6 HEAT repeat Helicase_C PF00271.31 EWC44054.1 - 1.2e-15 57.7 0.0 4.3e-15 56.0 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_2 PF13646.6 EWC44054.1 - 2.5e-05 24.6 9.9 0.025 14.9 0.0 7.2 8 0 0 8 8 8 1 HEAT repeats HEAT_EZ PF13513.6 EWC44054.1 - 5.2e-05 23.7 9.2 48 4.6 0.0 8.7 8 1 2 10 10 10 0 HEAT-like repeat ResIII PF04851.15 EWC44054.1 - 0.00026 21.0 0.0 0.001 19.1 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CLASP_N PF12348.8 EWC44054.1 - 0.0003 20.4 0.4 0.02 14.5 0.0 3.6 3 1 1 4 4 4 1 CLASP N terminal Vac14_Fab1_bd PF12755.7 EWC44054.1 - 0.0072 16.9 0.1 8.4 7.1 0.0 4.0 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region TAF6_C PF07571.13 EWC44054.1 - 0.096 13.0 0.2 5.6 7.4 0.0 3.5 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain Pkinase PF00069.25 EWC44055.1 - 9.1e-40 136.7 0.0 1.4e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44055.1 - 1.5e-27 96.5 0.0 2.3e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC44055.1 - 0.042 13.7 0.0 8.4 6.2 0.0 2.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EWC44055.1 - 0.076 12.4 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EWC44055.1 - 0.25 10.1 0.1 0.6 8.8 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase DUF5437 PF17505.2 EWC44056.1 - 0.0051 16.8 0.5 0.0074 16.3 0.5 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5437) bZIP_1 PF00170.21 EWC44057.1 - 1.7e-05 24.8 5.8 1.7e-05 24.8 5.8 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EWC44057.1 - 0.0054 16.8 7.6 0.012 15.7 7.6 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Mei4 PF13971.6 EWC44057.1 - 0.2 11.1 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Meiosis-specific protein Mei4 bZIP_Maf PF03131.17 EWC44057.1 - 0.78 10.3 8.1 0.33 11.5 5.3 1.8 2 0 0 2 2 2 0 bZIP Maf transcription factor DUF4407 PF14362.6 EWC44057.1 - 3.3 7.0 7.1 1.2 8.4 3.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Arrestin_C PF02752.22 EWC44058.1 - 7e-07 29.8 0.0 1.4e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EWC44058.1 - 0.028 14.5 0.1 0.074 13.1 0.1 1.7 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Med10 PF09748.9 EWC44059.1 - 3.1e-35 120.8 0.0 3.7e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex NAAA-beta PF15508.6 EWC44059.1 - 0.13 12.6 0.1 23 5.4 0.0 2.6 3 0 0 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Nuc_sug_transp PF04142.15 EWC44060.1 - 1.3e-06 27.9 0.2 2e-06 27.2 0.2 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EWC44060.1 - 2.1e-05 24.7 26.8 0.0032 17.7 10.6 2.9 3 1 0 3 3 3 2 EamA-like transporter family CRT-like PF08627.10 EWC44060.1 - 0.002 17.1 1.7 0.002 17.1 1.7 2.0 3 0 0 3 3 3 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EWC44060.1 - 0.0028 16.9 9.0 0.0054 16.0 9.0 1.4 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.16 EWC44060.1 - 0.15 11.4 8.1 0.17 11.2 0.8 2.2 2 0 0 2 2 2 0 Triose-phosphate Transporter family F-box-like PF12937.7 EWC44061.1 - 2.4e-09 37.0 0.1 6.4e-09 35.6 0.1 1.7 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EWC44061.1 - 3.5e-08 32.8 15.0 0.22 11.6 0.0 8.1 8 0 0 8 8 8 2 Leucine Rich repeat F-box PF00646.33 EWC44061.1 - 3.5e-06 26.7 0.1 1.1e-05 25.1 0.1 1.9 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EWC44061.1 - 0.051 14.0 12.6 12 6.5 0.0 5.4 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EWC44061.1 - 0.88 10.4 13.4 1.4e+02 3.6 0.0 7.0 6 1 0 6 6 6 0 Leucine Rich Repeat PXA PF02194.15 EWC44062.1 - 3e-48 164.2 1.2 5.7e-48 163.3 1.2 1.5 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 EWC44062.1 - 1.1e-05 26.0 0.0 0.00014 22.4 0.0 2.7 2 1 1 3 3 3 1 Sorting nexin C terminal HTH_Tnp_Tc5 PF03221.16 EWC44063.1 - 2.4e-08 33.9 0.0 5.2e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EWC44063.1 - 0.00077 19.0 0.0 0.0018 17.9 0.0 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Crp_2 PF13545.6 EWC44063.1 - 0.0082 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain MarR PF01047.22 EWC44063.1 - 0.0084 16.0 0.0 0.028 14.3 0.0 1.9 2 0 0 2 2 2 1 MarR family Sigma70_r4 PF04545.16 EWC44063.1 - 0.084 12.4 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_4 PF13613.6 EWC44063.1 - 0.092 12.5 0.0 0.26 11.1 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease DUF3544 PF12064.8 EWC44063.1 - 0.11 12.8 2.5 3 8.1 0.1 2.5 2 0 0 2 2 2 0 Protein kinase C-binding protein 1 HTH_23 PF13384.6 EWC44063.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_28 PF13518.6 EWC44063.1 - 0.22 11.7 3.0 0.44 10.7 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain CDO_I PF05995.12 EWC44064.1 - 1.7e-39 134.8 0.1 2.3e-39 134.4 0.1 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EWC44064.1 - 0.14 11.6 0.7 1.6 8.2 0.7 2.0 1 1 0 1 1 1 0 PCO_ADO zinc_ribbon_16 PF17034.5 EWC44065.1 - 3e-29 101.8 9.6 6.7e-29 100.6 9.6 1.6 1 0 0 1 1 1 1 Zinc-ribbon like family Nup84_Nup100 PF04121.13 EWC44065.1 - 0.00092 17.4 0.1 0.0013 16.9 0.1 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 WD40 PF00400.32 EWC44065.1 - 0.058 14.3 1.6 2.7 9.0 0.0 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat RAMP PF04901.13 EWC44065.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Receptor activity modifying family Sgf11 PF08209.11 EWC44065.1 - 0.3 10.7 4.0 3.3 7.4 0.7 2.7 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Zn_ribbon_17 PF17120.5 EWC44065.1 - 1.5 8.5 16.2 0.057 13.1 7.6 2.7 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type Efg1 PF10153.9 EWC44066.1 - 2.2e-33 115.0 2.0 2.4e-33 114.9 0.1 2.0 2 0 0 2 2 2 1 rRNA-processing protein Efg1 Asp-B-Hydro_N PF05279.11 EWC44066.1 - 0.046 13.8 0.7 0.1 12.6 0.7 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Fungal_trans PF04082.18 EWC44067.1 - 1.7e-28 99.4 0.0 7.6e-28 97.3 0.0 2.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44067.1 - 3.8e-11 42.9 12.6 6.8e-11 42.1 12.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OCRL_clath_bd PF16726.5 EWC44067.1 - 0.025 14.8 0.1 0.054 13.7 0.1 1.5 1 0 0 1 1 1 0 Inositol polyphosphate 5-phosphatase clathrin binding domain Suf PF05843.14 EWC44067.1 - 7.7 6.4 6.7 47 3.8 0.0 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Prenyltransf PF01255.19 EWC44070.1 - 1.6e-26 93.2 0.0 1.9e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase MAD PF05557.13 EWC44071.1 - 1.4e-29 103.0 67.3 1.6e-28 99.5 67.3 2.2 1 1 0 1 1 1 1 Mitotic checkpoint protein Golgin_A5 PF09787.9 EWC44071.1 - 0.0019 17.7 9.4 0.0019 17.7 9.4 4.8 3 1 1 4 4 4 3 Golgin subfamily A member 5 KLRAQ PF10205.9 EWC44071.1 - 0.011 16.0 3.4 0.011 16.0 3.4 5.6 4 2 1 5 5 5 0 Predicted coiled-coil domain-containing protein Lectin_N PF03954.14 EWC44071.1 - 0.018 14.8 2.5 0.018 14.8 2.5 5.1 4 2 2 6 6 6 0 Hepatic lectin, N-terminal domain TSC22 PF01166.18 EWC44071.1 - 1.9 8.8 32.1 1.6 9.1 1.0 7.6 6 2 2 8 8 8 0 TSC-22/dip/bun family zf-C2H2 PF00096.26 EWC44072.1 - 2.6e-21 74.8 29.2 1.1e-05 25.5 1.9 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC44072.1 - 2.2e-16 59.5 21.9 2.2e-06 27.9 0.9 4.9 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC44072.1 - 5.4e-09 36.1 26.4 0.068 14.0 1.2 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger FOXP-CC PF16159.5 EWC44072.1 - 0.0023 18.5 11.4 0.066 13.8 0.8 4.3 2 1 2 4 4 4 1 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 EWC44072.1 - 0.0024 17.6 1.9 0.0024 17.6 1.9 3.1 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-TRAF PF02176.18 EWC44072.1 - 0.0083 16.8 2.0 0.0083 16.8 2.0 3.1 2 1 1 3 3 3 2 TRAF-type zinc finger zf-C2H2_jaz PF12171.8 EWC44072.1 - 0.32 11.4 7.5 7.3 7.0 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EWC44072.1 - 1.1 9.1 16.7 9.8 6.0 2.6 4.6 4 0 0 4 4 4 0 C2H2-type zinc-finger domain SPR1 PF15356.6 EWC44072.1 - 2 9.0 8.3 4.3 7.9 4.1 2.2 1 1 1 2 2 2 0 Psoriasis susceptibility locus 2 zf-met PF12874.7 EWC44072.1 - 2.3 8.7 12.1 1.3 9.5 0.3 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type VPS13_mid_rpt PF16910.5 EWC44073.1 - 5.4e-95 317.3 23.5 1.4e-91 306.1 2.1 6.8 8 0 0 8 8 8 2 Repeating coiled region of VPS13 SHR-BD PF06650.12 EWC44073.1 - 1.5e-93 313.1 0.2 7.5e-92 307.5 0.1 2.9 2 1 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.5 EWC44073.1 - 2.9e-82 276.0 3.6 1.5e-79 267.1 0.1 3.5 3 0 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 EWC44073.1 - 8.5e-76 253.7 10.3 1.3e-71 240.1 0.4 3.3 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EWC44073.1 - 5.2e-43 145.9 1.7 9.4e-43 145.0 0.2 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EWC44073.1 - 3.5e-07 30.5 0.0 2.5e-06 27.8 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3979 PF13141.6 EWC44073.1 - 0.13 12.5 0.4 0.44 10.8 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3979) Utp14 PF04615.13 EWC44074.1 - 7.6e-78 262.9 18.7 4e-39 134.8 0.1 3.1 2 1 1 3 3 3 3 Utp14 protein DUF4549 PF15082.6 EWC44074.1 - 0.016 15.0 0.5 0.03 14.1 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) CLASP_N PF12348.8 EWC44075.1 - 2.6e-08 33.7 0.3 3.3e-07 30.1 0.2 2.4 2 0 0 2 2 2 1 CLASP N terminal HEAT_2 PF13646.6 EWC44075.1 - 3.8e-06 27.2 0.2 0.071 13.5 0.0 4.8 4 2 1 5 5 5 1 HEAT repeats HEAT PF02985.22 EWC44075.1 - 7.6e-06 25.8 1.1 6 7.4 0.0 5.9 6 0 0 6 6 6 1 HEAT repeat MMS19_N PF14500.6 EWC44075.1 - 0.00014 21.6 0.1 0.00076 19.1 0.1 2.3 2 1 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II Adaptin_N PF01602.20 EWC44075.1 - 0.00069 18.3 0.3 0.029 12.9 0.3 2.4 2 1 0 2 2 2 1 Adaptin N terminal region ERM PF00769.19 EWC44075.1 - 0.084 12.7 5.8 0.24 11.2 5.8 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF445 PF04286.12 EWC44075.1 - 0.3 10.8 5.3 0.51 10.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Transket_pyr PF02779.24 EWC44076.1 - 2.1e-63 213.2 0.0 3.3e-63 212.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EWC44076.1 - 8.1e-59 199.0 0.0 1.3e-58 198.3 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EWC44076.1 - 2.8e-53 179.7 0.0 5.2e-53 178.8 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EWC44076.1 - 9.9e-21 73.1 0.9 2.1e-20 72.0 0.9 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus Glyco_hydro_17 PF00332.18 EWC44076.1 - 0.017 14.7 0.2 3.7 7.1 0.1 2.5 3 0 0 3 3 3 0 Glycosyl hydrolases family 17 ING PF12998.7 EWC44077.1 - 5.3e-14 52.6 0.0 1.1e-06 29.2 0.0 2.4 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EWC44077.1 - 9.5e-06 25.4 7.7 1.6e-05 24.7 7.7 1.4 1 0 0 1 1 1 1 PHD-finger SLY PF12485.8 EWC44077.1 - 0.01 16.6 2.6 0.029 15.1 2.6 1.7 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein PHD_2 PF13831.6 EWC44077.1 - 0.25 11.0 3.2 0.43 10.2 3.2 1.4 1 0 0 1 1 1 0 PHD-finger WD40 PF00400.32 EWC44078.1 - 1.9e-41 139.2 22.6 4.2e-06 27.4 0.6 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EWC44078.1 - 7.7e-10 38.5 0.5 1.7e-09 37.4 0.5 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC44078.1 - 6.8e-09 35.4 0.2 1.5e-08 34.3 0.2 1.6 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EWC44078.1 - 2.8e-08 33.9 1.0 0.53 10.6 0.0 5.2 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC44078.1 - 0.00014 20.7 4.9 1.5 7.4 0.2 5.5 3 1 3 6 6 6 1 Nucleoporin Nup120/160 PQQ_2 PF13360.6 EWC44078.1 - 0.00074 19.2 0.9 0.67 9.5 0.0 2.9 1 1 2 3 3 3 3 PQQ-like domain F-box_4 PF15966.5 EWC44078.1 - 0.14 12.0 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 F-box adh_short PF00106.25 EWC44080.1 - 1e-05 25.1 0.4 0.031 13.7 0.5 3.3 2 1 0 2 2 2 2 short chain dehydrogenase ATP_bind_3 PF01171.20 EWC44081.1 - 3.1e-18 66.2 0.0 5.1e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 PP-loop family TF_Zn_Ribbon PF08271.12 EWC44081.1 - 0.048 13.2 1.0 0.23 11.0 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding tRNA_Me_trans PF03054.16 EWC44081.1 - 0.11 11.3 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase SAT PF16073.5 EWC44081.1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Cyclin_N PF00134.23 EWC44082.1 - 3.2e-13 49.5 0.0 5.4e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EWC44082.1 - 2.8e-08 34.3 0.2 7.3e-08 32.9 0.0 1.8 2 0 0 2 2 2 1 Cyclin Aha1_N PF09229.11 EWC44083.1 - 6e-22 78.3 0.3 3.8e-12 46.6 0.0 2.3 1 1 1 2 2 2 2 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EWC44083.1 - 2.7e-14 53.4 0.1 4.1e-14 52.9 0.1 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Uds1 PF15456.6 EWC44084.1 - 8.5e-35 119.8 0.8 8.5e-35 119.8 0.8 7.5 7 1 1 8 8 8 2 Up-regulated During Septation APG6_N PF17675.1 EWC44084.1 - 0.0025 18.3 5.7 0.0025 18.3 5.7 8.0 3 2 4 7 7 7 1 Apg6 coiled-coil region DUF1192 PF06698.11 EWC44084.1 - 0.03 14.4 1.0 0.03 14.4 1.0 6.2 7 0 0 7 7 7 0 Protein of unknown function (DUF1192) T7SS_ESX_EspC PF10824.8 EWC44084.1 - 0.051 14.1 0.3 0.051 14.1 0.3 5.0 5 1 1 6 6 6 0 Excreted virulence factor EspC, type VII ESX diderm VGPC1_C PF16799.5 EWC44084.1 - 2.9 8.0 21.8 0.59 10.2 1.2 4.6 3 1 1 4 4 4 0 C-terminal membrane-localisation domain of ion-channel, VCN1 BLM10_mid PF16507.5 EWC44085.1 - 1.9e-192 640.6 0.0 2.6e-192 640.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EWC44085.1 - 1e-29 102.3 0.0 7.7e-29 99.5 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EWC44085.1 - 1.4e-18 66.9 0.1 3.5e-18 65.7 0.1 1.7 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal HEAT PF02985.22 EWC44085.1 - 0.0046 17.1 0.0 6.3 7.3 0.0 4.7 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 EWC44085.1 - 2.7 8.6 9.8 3.6 8.2 0.0 5.1 6 0 0 6 6 6 0 HEAT-like repeat DUF2628 PF10947.8 EWC44086.1 - 0.19 12.1 8.2 0.28 11.6 6.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2628) BSD PF03909.17 EWC44088.1 - 2.3e-22 78.8 1.7 5.4e-10 39.1 0.3 2.7 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 EWC44088.1 - 2.6e-17 62.9 0.1 5.1e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain PTB PF08416.13 EWC44088.1 - 0.0033 17.6 1.4 0.0062 16.7 0.1 2.0 3 0 0 3 3 3 1 Phosphotyrosine-binding domain CysG_dimeriser PF10414.9 EWC44088.1 - 0.19 11.5 1.2 8.8 6.1 0.1 2.6 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region VID27 PF08553.10 EWC44089.1 - 7.8e-188 623.8 0.1 1.1e-187 623.4 0.1 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EWC44089.1 - 4.8e-65 218.6 0.9 4.8e-65 218.6 0.9 2.2 3 0 0 3 3 3 1 VID27 N-terminal region VID27_PH PF17747.1 EWC44089.1 - 2.5e-37 127.5 0.2 5.8e-37 126.3 0.2 1.7 1 0 0 1 1 1 1 VID27 PH-like domain Usp PF00582.26 EWC44090.1 - 2.3e-11 44.4 0.0 0.00023 21.7 0.0 2.7 2 0 0 2 2 2 2 Universal stress protein family Peptidase_M6 PF05547.11 EWC44091.1 - 3.4e-07 29.0 0.4 0.0058 15.0 0.9 2.2 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 MliC PF09864.9 EWC44091.1 - 0.048 13.6 0.2 6.6 6.8 0.1 2.7 2 0 0 2 2 2 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme MFS_1 PF07690.16 EWC44093.1 - 4.5e-45 154.1 44.2 4.5e-45 154.1 44.2 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EWC44093.1 - 3.2e-17 62.2 27.5 4.7e-17 61.6 27.5 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EWC44093.1 - 1.3e-12 47.4 11.7 1.3e-12 47.4 11.7 2.9 2 1 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EWC44093.1 - 0.094 11.0 18.9 0.082 11.2 0.8 3.1 4 0 0 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family Thioesterase PF00975.20 EWC44094.1 - 8.4e-16 58.8 0.0 2.6e-15 57.2 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EWC44094.1 - 1.8e-06 28.7 0.0 2.3e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EWC44094.1 - 0.02 14.7 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase AMP-binding PF00501.28 EWC44095.1 - 5.3e-79 265.8 0.0 7.6e-79 265.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 EWC44095.1 - 2.7e-71 240.1 0.0 4.9e-71 239.3 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Condensation PF00668.20 EWC44095.1 - 2e-69 234.5 0.0 3.4e-69 233.7 0.0 1.3 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 EWC44095.1 - 5.2e-55 186.1 0.1 2.6e-54 183.9 0.1 2.3 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EWC44095.1 - 4.4e-48 164.4 0.0 7.4e-48 163.7 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EWC44095.1 - 5.5e-38 129.6 0.1 1.4e-37 128.3 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EWC44095.1 - 2.7e-30 105.4 0.0 8e-30 103.8 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein PP-binding PF00550.25 EWC44095.1 - 1.1e-18 67.3 0.1 1.5e-10 41.2 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EWC44095.1 - 4e-18 65.9 0.0 1.1e-17 64.5 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 EWC44095.1 - 4.4e-18 65.6 0.0 7.4e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase adh_short PF00106.25 EWC44095.1 - 4.6e-10 39.3 0.0 2e-09 37.2 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase ACP_syn_III PF08545.10 EWC44095.1 - 0.0098 15.7 0.1 0.03 14.2 0.1 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 EWC44095.1 - 0.019 14.3 0.2 0.037 13.4 0.2 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain AMP-binding_C PF13193.6 EWC44095.1 - 0.19 12.7 0.0 0.56 11.2 0.0 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Diedel PF13164.6 EWC44096.1 - 0.38 11.2 8.8 0.13 12.7 0.9 2.2 2 0 0 2 2 2 0 Diedel Ribosomal_L30_N PF08079.12 EWC44097.1 - 3.5e-24 84.9 15.2 6.2e-24 84.0 15.2 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EWC44097.1 - 5e-19 67.9 1.1 2e-18 66.0 1.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Aminotran_5 PF00266.19 EWC44097.1 - 7.2e-12 44.9 0.0 1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EWC44097.1 - 0.02 14.2 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EWC44097.1 - 0.065 11.8 0.0 0.098 11.2 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DNA_pol_B PF00136.21 EWC44098.1 - 6.1e-110 368.1 0.0 1.2e-109 367.1 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EWC44098.1 - 1.4e-56 191.1 3.0 2.9e-56 190.1 3.0 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EWC44098.1 - 4.6e-37 127.9 0.0 7e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EWC44098.1 - 1.5e-20 73.1 7.7 1.5e-20 73.1 7.7 2.6 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal Fungal_trans PF04082.18 EWC44099.1 - 1.3e-30 106.3 0.0 2.3e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44099.1 - 0.18 11.9 3.0 0.32 11.1 3.0 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PWI PF01480.17 EWC44101.1 - 6.8e-13 48.7 0.7 2e-12 47.3 0.7 1.8 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 EWC44101.1 - 2e-05 24.3 0.0 4.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.29 EWC44102.1 - 7.6e-37 126.7 0.0 2.2e-36 125.2 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC44102.1 - 9.8e-10 38.1 0.1 2.8e-09 36.6 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EWC44102.1 - 5.8e-07 29.4 0.0 1.5e-06 28.1 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EWC44102.1 - 4.1e-06 26.8 0.2 7.9e-05 22.7 0.2 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EWC44102.1 - 5.6e-06 26.9 0.1 0.00011 22.6 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EWC44102.1 - 6.6e-06 26.4 0.1 0.0018 18.6 0.1 2.7 2 1 0 2 2 1 1 AAA domain AAA_14 PF13173.6 EWC44102.1 - 1.2e-05 25.3 0.0 2.4e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EWC44102.1 - 6.3e-05 23.2 0.0 0.00017 21.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EWC44102.1 - 0.00044 20.4 0.0 0.00085 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EWC44102.1 - 0.00058 19.3 0.2 0.0017 17.8 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EWC44102.1 - 0.00059 20.4 0.1 0.0023 18.5 0.0 2.0 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EWC44102.1 - 0.00086 19.1 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TniB PF05621.11 EWC44102.1 - 0.00086 18.8 0.0 1.4 8.3 0.0 2.7 3 0 0 3 3 3 2 Bacterial TniB protein AAA_25 PF13481.6 EWC44102.1 - 0.00089 18.9 1.0 0.037 13.6 0.1 2.7 2 1 1 3 3 3 1 AAA domain TIP49 PF06068.13 EWC44102.1 - 0.0032 16.8 0.1 0.085 12.1 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 EWC44102.1 - 0.0035 17.7 0.0 0.0069 16.8 0.0 1.7 1 1 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 EWC44102.1 - 0.0042 16.8 0.0 0.0072 16.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EWC44102.1 - 0.0068 16.7 0.0 0.018 15.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain NACHT PF05729.12 EWC44102.1 - 0.007 16.3 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Rad17 PF03215.15 EWC44102.1 - 0.0072 16.3 0.1 0.021 14.7 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain Parvo_NS1 PF01057.17 EWC44102.1 - 0.015 14.4 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 EWC44102.1 - 0.015 15.4 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Guanylate_kin PF00625.21 EWC44102.1 - 0.018 14.7 0.0 0.79 9.4 0.0 2.6 3 0 0 3 3 3 0 Guanylate kinase Zeta_toxin PF06414.12 EWC44102.1 - 0.024 13.9 0.0 0.048 12.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 EWC44102.1 - 0.025 14.1 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EWC44102.1 - 0.031 14.8 0.0 0.066 13.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter ATPase_2 PF01637.18 EWC44102.1 - 0.036 14.0 0.2 0.22 11.4 0.0 2.2 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 EWC44102.1 - 0.048 13.4 0.0 0.12 12.0 0.0 1.6 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_21 PF13304.6 EWC44102.1 - 0.06 13.2 0.3 4.9 6.9 0.2 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system CPT PF07931.12 EWC44102.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DUF815 PF05673.13 EWC44102.1 - 0.065 12.4 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TsaE PF02367.17 EWC44102.1 - 0.087 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 EWC44102.1 - 0.095 12.0 0.1 1.7 7.9 0.0 2.3 1 1 1 2 2 2 0 KaiC NB-ARC PF00931.22 EWC44102.1 - 0.12 11.5 0.0 0.28 10.3 0.0 1.7 1 1 0 1 1 1 0 NB-ARC domain PGI PF00342.19 EWC44103.1 - 1.4e-237 789.1 1.1 1.6e-237 788.9 1.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Dip PF17679.1 EWC44103.1 - 0.055 13.1 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 gp37/Dip protein GCP_N_terminal PF17681.1 EWC44104.1 - 1.5e-66 225.1 0.1 2.5e-66 224.4 0.1 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EWC44104.1 - 7.3e-60 203.0 2.9 1.5e-59 202.0 2.9 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal SMC_N PF02463.19 EWC44105.1 - 1.7e-69 233.6 0.0 3e-69 232.8 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EWC44105.1 - 1.8e-21 76.6 1.2 1.7e-20 73.5 0.1 3.0 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EWC44105.1 - 1.3e-09 38.3 4.2 0.00017 21.5 0.1 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EWC44105.1 - 0.001 18.8 0.1 0.0025 17.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tup_N PF08581.10 EWC44105.1 - 0.017 15.4 2.8 0.017 15.4 2.8 8.4 5 3 3 9 9 9 0 Tup N-terminal SLATT_5 PF18160.1 EWC44105.1 - 0.35 10.2 5.5 0.37 10.1 2.3 2.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 ABC_tran PF00005.27 EWC44105.1 - 1.3 9.5 24.1 1.7 9.2 0.1 5.7 3 2 0 3 3 3 0 ABC transporter Sugarporin_N PF11471.8 EWC44105.1 - 3.8 7.5 8.7 0.72 9.8 1.5 3.1 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension GDI PF00996.18 EWC44106.1 - 3e-159 530.2 0.0 3.7e-159 529.9 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor MRP-L47 PF06984.13 EWC44107.1 - 1e-21 76.9 1.1 1.3e-21 76.5 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Clc-like PF07062.12 EWC44107.1 - 0.023 14.2 1.0 0.038 13.4 1.0 1.2 1 0 0 1 1 1 0 Clc-like SUD-M PF11633.8 EWC44107.1 - 0.22 11.2 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Single-stranded poly(A) binding domain SAP30_Sin3_bdg PF13867.6 EWC44108.1 - 4.3e-09 36.6 0.1 6.8e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 TFIIA PF03153.13 EWC44108.1 - 2.2 8.2 3.8 2.6 8.0 3.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF5525 PF17663.1 EWC44108.1 - 5.9 4.8 19.4 7.2 4.5 19.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5525) Xan_ur_permease PF00860.20 EWC44109.1 - 4.7e-65 219.8 30.1 3e-63 213.9 30.1 2.1 1 1 0 1 1 1 1 Permease family Cyt-b5 PF00173.28 EWC44110.1 - 8.9e-17 61.0 0.3 3.1e-16 59.3 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 EWC44110.1 - 5.5e-16 59.2 14.0 5.5e-16 59.2 14.0 2.0 1 1 1 2 2 2 1 Fatty acid desaturase DnaJ_C PF01556.18 EWC44111.1 - 6e-37 127.0 0.0 8.1e-37 126.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EWC44111.1 - 1.1e-24 86.3 3.8 1.1e-24 86.3 3.8 2.5 3 0 0 3 3 3 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EWC44111.1 - 8.4e-09 35.7 18.7 1.6e-08 34.8 18.7 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EWC44111.1 - 0.18 11.8 18.1 0.37 10.8 4.3 2.6 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein CUE PF02845.16 EWC44112.1 - 1.6e-06 27.7 0.0 2.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 CUE domain Cue1_U7BR PF18499.1 EWC44112.1 - 0.072 13.1 1.9 0.14 12.2 1.9 1.4 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 WD40 PF00400.32 EWC44113.1 - 2.6e-30 104.0 17.9 8.4e-07 29.6 1.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC44113.1 - 2.5e-14 53.3 4.2 0.011 16.1 0.3 5.7 3 2 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain PP2C_2 PF13672.6 EWC44113.1 - 0.0057 16.3 0.7 0.081 12.5 0.2 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C IKI3 PF04762.12 EWC44113.1 - 0.014 13.4 1.7 0.07 11.1 0.4 2.1 2 0 0 2 2 2 0 IKI3 family Coatomer_WDAD PF04053.14 EWC44113.1 - 0.093 11.8 6.7 0.58 9.1 0.7 2.5 2 1 1 3 3 3 0 Coatomer WD associated region TcfC PF16967.5 EWC44113.1 - 0.2 11.2 0.0 0.6 9.6 0.0 1.8 2 0 0 2 2 2 0 E-set like domain Proteasome PF00227.26 EWC44114.1 - 8.1e-37 126.6 0.0 1e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Peptidase_M3 PF01432.20 EWC44115.1 - 2.5e-150 501.7 0.0 3.7e-150 501.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 EF-hand_9 PF14658.6 EWC44116.1 - 7.4e-15 55.0 0.0 9.8e-10 38.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EWC44116.1 - 3.3e-10 40.3 0.2 1.8e-05 25.1 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EWC44116.1 - 7.5e-10 37.9 0.7 0.00071 19.3 0.1 3.4 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EWC44116.1 - 8.7e-10 37.4 0.1 0.0004 19.7 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EWC44116.1 - 8.8e-06 25.5 0.0 5.6e-05 22.9 0.0 2.3 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_14 PF17959.1 EWC44116.1 - 0.023 15.0 0.0 0.76 10.2 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain GPHH PF16905.5 EWC44116.1 - 0.07 12.9 0.0 0.85 9.4 0.0 2.4 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Thioredoxin_3 PF13192.6 EWC44116.1 - 0.085 12.9 0.0 0.23 11.5 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin domain SapB_1 PF05184.15 EWC44116.1 - 0.29 11.2 0.6 9.9 6.3 0.1 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 1 CDC45 PF02724.14 EWC44117.1 - 0.1 10.9 4.8 0.11 10.8 4.8 1.2 1 0 0 1 1 1 0 CDC45-like protein PYST-C1 PF09690.10 EWC44117.1 - 0.27 11.0 0.1 0.27 11.0 0.1 2.4 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) Nop14 PF04147.12 EWC44117.1 - 0.29 9.3 7.3 0.41 8.8 7.3 1.2 1 0 0 1 1 1 0 Nop14-like family DUF3292 PF11696.8 EWC44117.1 - 0.45 8.8 3.0 0.62 8.4 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) GCIP PF13324.6 EWC44117.1 - 0.57 9.8 3.1 0.76 9.3 3.1 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RRN3 PF05327.11 EWC44117.1 - 1.3 7.4 4.0 1.9 6.9 4.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 EWC44117.1 - 1.7 7.8 5.0 2.9 7.0 5.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit YL1 PF05764.13 EWC44117.1 - 5.1 7.1 17.4 15 5.6 17.5 1.6 1 1 0 1 1 1 0 YL1 nuclear protein Peptidase_M28 PF04389.17 EWC44118.1 - 4.2e-29 101.6 0.0 6.7e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EWC44118.1 - 8.9e-08 32.1 0.1 1.8e-07 31.1 0.1 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 NOZZLE PF08744.10 EWC44119.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Plant transcription factor NOZZLE CoA_binding_2 PF13380.6 EWC44121.1 - 2.1e-30 105.6 0.0 2.4e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain ATP19 PF11022.8 EWC44122.1 - 2.8e-16 59.6 0.1 3.2e-16 59.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K MTP18 PF10558.9 EWC44123.1 - 9.9e-77 256.7 0.2 1.2e-76 256.5 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) Chitin_synth_1 PF01644.17 EWC44124.1 - 1e-79 266.2 0.0 1.7e-79 265.5 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EWC44124.1 - 8.2e-28 96.2 0.2 2e-27 95.0 0.2 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EWC44124.1 - 9.4e-24 83.9 2.7 9.4e-19 67.4 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EWC44124.1 - 5.1e-07 29.8 2.1 1.5e-06 28.3 2.1 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 CitMHS PF03600.16 EWC44124.1 - 0.22 10.7 3.1 0.36 10.0 3.1 1.3 1 0 0 1 1 1 0 Citrate transporter CDC45 PF02724.14 EWC44124.1 - 2.3 6.4 11.3 3.5 5.8 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2070 PF09843.9 EWC44124.1 - 5.3 5.2 12.5 9.3 4.4 12.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) NOA36 PF06524.12 EWC44124.1 - 7.9 5.7 11.1 14 4.9 11.1 1.3 1 0 0 1 1 1 0 NOA36 protein AFG1_ATPase PF03969.16 EWC44125.1 - 5.5e-94 315.0 0.1 7.9e-90 301.3 0.0 3.0 3 0 0 3 3 3 2 AFG1-like ATPase AAA_16 PF13191.6 EWC44125.1 - 0.00016 22.1 0.1 0.09 13.1 0.1 2.6 1 1 0 1 1 1 1 AAA ATPase domain Bac_DnaA PF00308.18 EWC44125.1 - 0.0027 17.6 0.3 0.095 12.5 0.2 2.4 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_22 PF13401.6 EWC44125.1 - 0.0029 17.9 0.0 0.018 15.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EWC44125.1 - 0.021 14.8 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EWC44125.1 - 0.039 14.4 0.0 0.092 13.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EWC44125.1 - 0.18 11.7 0.7 0.8 9.6 0.0 2.5 3 1 0 3 3 3 0 NACHT domain FKBP_C PF00254.28 EWC44127.1 - 5.6e-35 119.5 0.0 6.5e-35 119.3 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase bMG5 PF17972.1 EWC44127.1 - 0.02 15.3 0.0 0.031 14.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG5 domain TGT PF01702.18 EWC44128.1 - 3.1e-108 362.0 0.0 3.5e-108 361.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase RecA_dep_nuc PF16786.5 EWC44128.1 - 0.083 13.0 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Recombination enhancement, RecA-dependent nuclease Ribosomal_S17e PF00833.18 EWC44129.1 - 1.8e-58 195.8 0.4 2.1e-58 195.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal S17 Adaptin_N PF01602.20 EWC44130.1 - 1.1e-118 397.1 2.2 1.3e-118 396.8 2.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EWC44130.1 - 5.3e-56 189.1 5.4 1.9e-55 187.3 0.0 3.3 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC44130.1 - 3e-13 50.0 5.4 4.2e-08 33.5 0.1 4.7 4 1 0 4 4 4 3 HEAT repeats HEAT PF02985.22 EWC44130.1 - 8.5e-11 41.1 3.6 0.022 15.0 0.0 5.7 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 EWC44130.1 - 8.5e-07 29.4 1.5 8.9 6.9 0.0 6.2 6 0 0 6 6 6 2 HEAT-like repeat CLASP_N PF12348.8 EWC44130.1 - 0.01 15.4 0.6 3.2 7.3 0.1 3.1 2 1 0 2 2 2 0 CLASP N terminal RTP1_C1 PF10363.9 EWC44130.1 - 0.011 15.9 1.2 0.99 9.6 0.1 3.6 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 RICTOR_N PF14664.6 EWC44130.1 - 0.024 13.7 5.5 1.8 7.5 0.4 3.5 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, N-term Arm PF00514.23 EWC44130.1 - 0.025 14.6 4.3 3.2 7.9 0.0 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat TetR_C_14 PF17754.1 EWC44130.1 - 0.11 12.5 0.3 1.3 9.0 0.3 2.4 2 0 0 2 2 2 0 MftR C-terminal domain DUF1077 PF06417.12 EWC44131.1 - 1.9e-46 156.9 2.4 2.3e-46 156.6 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Rad4 PF03835.15 EWC44132.1 - 1e-29 103.2 0.1 2.1e-29 102.1 0.1 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EWC44132.1 - 2.8e-23 82.1 0.0 5.6e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 EWC44132.1 - 3.4e-19 69.6 2.2 5.6e-19 68.9 0.4 2.5 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 EWC44132.1 - 2e-15 56.3 0.0 4.1e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 EWC44132.1 - 0.00025 21.5 0.0 0.00073 20.0 0.0 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SUIM_assoc PF16619.5 EWC44132.1 - 0.72 10.0 5.0 0.26 11.4 0.8 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 EAP30 PF04157.16 EWC44133.1 - 6e-39 133.7 0.9 8.1e-39 133.3 0.9 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 EWC44133.1 - 1.1e-22 80.0 0.0 2.2e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Vps36-NZF-N PF16988.5 EWC44133.1 - 3.3e-17 61.6 2.1 3.3e-17 61.6 2.1 3.2 4 0 0 4 4 4 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 EWC44133.1 - 3.8e-05 23.6 5.7 0.0023 18.0 0.9 2.5 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EWC44133.1 - 0.0018 17.6 4.8 0.51 9.7 0.1 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others GRAM PF02893.20 EWC44133.1 - 0.024 14.5 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 GRAM domain Spt4 PF06093.13 EWC44133.1 - 0.14 12.3 0.3 0.41 10.8 0.3 1.8 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger LUC7 PF03194.15 EWC44133.1 - 0.3 10.7 0.4 0.71 9.5 0.2 1.6 2 0 0 2 2 2 0 LUC7 N_terminus DZR PF12773.7 EWC44133.1 - 0.42 10.7 6.9 0.77 9.8 0.9 2.3 1 1 2 3 3 3 0 Double zinc ribbon RecR PF02132.15 EWC44133.1 - 1 9.0 6.8 2.3 7.9 2.8 2.8 2 0 0 2 2 2 0 RecR protein Ran_BP1 PF00638.18 EWC44134.1 - 1.3e-14 54.5 0.5 2.8e-13 50.2 0.5 2.5 1 1 1 2 2 2 1 RanBP1 domain cobW PF02492.19 EWC44135.1 - 5.3e-44 149.9 0.5 2.4e-43 147.8 0.5 1.9 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EWC44135.1 - 1.4e-05 25.1 1.1 0.14 12.0 0.0 2.8 3 0 0 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EWC44135.1 - 0.00013 22.4 0.0 0.0003 21.2 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain CobW_C PF07683.14 EWC44135.1 - 0.00013 21.8 0.0 0.00023 21.0 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 EWC44135.1 - 0.0045 17.3 0.1 0.027 14.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EWC44135.1 - 0.01 16.4 0.1 0.22 12.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EWC44135.1 - 0.013 14.5 0.1 8.1 5.3 0.0 3.2 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EWC44135.1 - 0.026 13.8 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 EWC44135.1 - 0.028 14.4 0.0 0.072 13.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GTP_EFTU PF00009.27 EWC44135.1 - 0.029 13.9 0.1 7.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EWC44135.1 - 0.029 14.4 0.1 0.27 11.3 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase T2SSE PF00437.20 EWC44135.1 - 0.037 13.1 0.0 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EWC44135.1 - 0.05 14.1 0.0 0.16 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EWC44135.1 - 0.051 13.5 0.3 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EWC44135.1 - 0.079 13.0 0.1 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EWC44135.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 EWC44135.1 - 0.12 12.1 0.1 0.67 9.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EWC44135.1 - 0.16 11.8 0.0 0.76 9.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain Choline_transpo PF04515.12 EWC44136.1 - 9.6e-85 284.6 25.0 9.6e-85 284.6 25.0 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter Glyoxal_oxid_N PF07250.11 EWC44136.1 - 1.1e-44 152.5 0.0 6.9e-44 149.8 0.0 2.2 1 1 0 1 1 1 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EWC44136.1 - 2.2e-14 53.5 0.2 4.8e-14 52.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Chitin_bind_1 PF00187.19 EWC44136.1 - 0.012 16.1 8.9 0.012 16.1 8.9 1.9 2 0 0 2 2 2 0 Chitin recognition protein Kelch_4 PF13418.6 EWC44136.1 - 0.096 12.7 0.2 10 6.2 0.0 3.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 EWC44136.1 - 0.6 10.2 2.1 60 3.8 0.0 4.0 3 0 0 3 3 3 0 Kelch motif Deltameth_res PF16020.5 EWC44136.1 - 4.1 7.4 8.8 7 6.6 0.0 4.2 3 1 0 3 3 3 0 Deltamethrin resistance Peptidase_C37 PF05416.12 EWC44137.1 - 0.11 11.1 0.0 0.14 10.6 0.0 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase G-patch PF01585.23 EWC44138.1 - 2.2e-12 46.7 1.1 5.6e-12 45.4 1.1 1.7 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 EWC44138.1 - 8.9e-10 37.7 1.1 1.6e-09 36.9 1.1 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EWC44138.1 - 2.6e-08 33.6 0.2 1.8e-07 30.9 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 EWC44138.1 - 8.9e-06 25.7 0.8 3.2e-05 23.9 0.8 1.9 1 0 0 1 1 1 1 G-patch domain RED_N PF07808.13 EWC44138.1 - 0.012 15.2 3.1 0.012 15.2 3.1 1.8 2 0 0 2 2 2 0 RED-like protein N-terminal region zf-C2H2_jaz PF12171.8 EWC44138.1 - 0.028 14.7 0.5 0.068 13.5 0.5 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Rad50_zn_hook PF04423.14 EWC44138.1 - 0.051 13.4 0.8 0.17 11.7 0.8 1.9 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-met PF12874.7 EWC44138.1 - 3.5 8.1 6.1 0.6 10.6 0.8 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF4674 PF15719.5 EWC44138.1 - 8.3 6.4 11.2 1.6 8.7 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4674) Kelch_5 PF13854.6 EWC44139.1 - 4.1e-08 33.0 4.8 0.016 15.2 0.2 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EWC44139.1 - 0.0082 16.1 3.2 7.6 6.7 0.0 4.7 6 0 0 6 6 6 1 Kelch motif Kelch_6 PF13964.6 EWC44139.1 - 0.066 13.5 7.9 8.5 6.8 0.2 4.5 4 0 0 4 4 4 0 Kelch motif CD225 PF04505.12 EWC44139.1 - 0.15 12.2 0.2 0.33 11.1 0.2 1.6 1 0 0 1 1 1 0 Interferon-induced transmembrane protein Kelch_1 PF01344.25 EWC44139.1 - 5.1 6.8 8.9 7.8 6.2 0.0 4.5 5 0 0 5 5 5 0 Kelch motif YajC PF02699.15 EWC44139.1 - 6.5 6.7 5.1 5.4 7.0 0.3 2.2 1 1 1 2 2 2 0 Preprotein translocase subunit Coatomer_WDAD PF04053.14 EWC44141.1 - 1.1e-170 568.5 0.0 1.9e-170 567.7 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 EWC44141.1 - 3e-36 122.8 8.9 7.7e-06 26.6 0.1 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC44141.1 - 1.4e-08 35.0 0.1 1.4 9.3 0.0 6.0 5 2 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC44141.1 - 0.00029 19.6 2.3 0.24 10.0 0.0 3.7 1 1 3 4 4 4 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EWC44141.1 - 0.0013 18.8 0.1 0.95 9.5 0.0 4.5 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Cwf_Cwc_15 PF04889.12 EWC44141.1 - 2.2 8.0 6.9 3.2 7.4 6.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein GPI2 PF06432.11 EWC44142.1 - 7e-65 219.2 0.0 8.7e-65 218.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase ABC1 PF03109.16 EWC44143.1 - 8.9e-26 90.4 0.0 2e-25 89.3 0.0 1.6 1 0 0 1 1 1 1 ABC1 family SCO1-SenC PF02630.14 EWC44144.1 - 1.5e-46 157.7 0.0 1.9e-46 157.3 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EWC44144.1 - 2.5e-05 24.2 0.0 5.1e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EWC44144.1 - 0.048 13.4 0.0 1 9.1 0.0 2.2 1 1 0 1 1 1 0 Redoxin Thioredoxin_8 PF13905.6 EWC44144.1 - 0.11 12.8 0.0 0.27 11.6 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like Big_6 PF17936.1 EWC44144.1 - 0.18 12.1 0.1 0.7 10.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial Ig domain SNARE PF05739.19 EWC44145.1 - 1e-13 51.0 0.8 1.6e-13 50.4 0.1 1.7 2 0 0 2 2 2 1 SNARE domain Syntaxin-5_N PF11416.8 EWC44145.1 - 1.3e-06 27.5 3.6 1.3e-06 27.5 3.6 1.9 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin-18_N PF10496.9 EWC44145.1 - 0.00072 19.8 0.1 0.0044 17.2 0.0 2.3 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Syntaxin PF00804.25 EWC44145.1 - 0.0015 18.3 1.6 0.021 14.5 0.2 2.5 2 1 0 2 2 2 1 Syntaxin KxDL PF10241.9 EWC44145.1 - 0.0037 17.5 1.0 4.3 7.7 0.1 3.0 3 0 0 3 3 3 2 Uncharacterized conserved protein DUF4988 PF16378.5 EWC44145.1 - 0.0088 15.7 1.0 0.97 9.1 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function Spc7 PF08317.11 EWC44145.1 - 0.019 13.9 1.1 0.036 13.0 0.8 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein NPV_P10 PF05531.12 EWC44145.1 - 0.97 9.9 5.2 31 5.1 0.1 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 EWC44145.1 - 1.3 9.5 3.9 0.62 10.6 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 Prominin PF05478.11 EWC44145.1 - 1.7 6.5 5.7 3 5.7 0.5 2.2 1 1 0 2 2 2 0 Prominin CorA PF01544.18 EWC44147.1 - 1.8e-08 34.0 0.1 5.3e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein RAG1_imp_bd PF12560.8 EWC44148.1 - 8.4 5.8 6.5 0.45 10.0 1.2 1.5 2 0 0 2 2 2 0 RAG1 importin binding Arf PF00025.21 EWC44149.1 - 2.5e-80 268.0 0.1 2.8e-80 267.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EWC44149.1 - 1.5e-14 54.3 0.0 2.1e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EWC44149.1 - 2.6e-14 53.1 0.0 3.2e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EWC44149.1 - 1.6e-13 50.6 0.0 1.8e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EWC44149.1 - 4.2e-13 49.2 1.2 4.2e-09 36.0 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EWC44149.1 - 7.5e-11 41.8 0.0 9.2e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EWC44149.1 - 2.2e-06 27.7 0.0 3.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EWC44149.1 - 0.0073 15.6 0.7 0.02 14.2 0.7 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase Choline_kinase PF01633.20 EWC44150.1 - 1.2e-42 145.9 0.0 1.9e-41 142.0 0.0 2.2 2 1 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EWC44150.1 - 6.1e-05 23.1 0.0 0.00019 21.5 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family adh_short_C2 PF13561.6 EWC44151.1 - 1.5e-27 96.7 0.8 1.8e-27 96.4 0.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EWC44151.1 - 8.5e-20 71.0 0.2 1.1e-19 70.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EWC44151.1 - 9.2e-07 28.9 0.1 1.3e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EWC44151.1 - 0.11 11.9 0.2 0.43 10.0 0.1 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF3405 PF11885.8 EWC44152.1 - 8.9e-121 404.0 0.8 1.5e-120 403.3 0.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) SR-25 PF10500.9 EWC44152.1 - 0.44 10.1 4.2 0.8 9.3 4.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SpoU_methylase PF00588.19 EWC44153.1 - 4.2e-23 82.1 0.0 7.6e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EWC44153.1 - 7.7e-06 26.1 0.0 7.7e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding DSBA PF01323.20 EWC44153.1 - 0.019 14.7 1.0 0.076 12.8 0.0 2.2 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Recep_L_domain PF01030.24 EWC44154.1 - 5.9e-10 39.3 1.4 0.00018 21.6 0.0 3.9 2 2 2 4 4 4 4 Receptor L domain zf-PHD-like PF15446.6 EWC44155.1 - 2.5e-54 183.4 13.5 5.3e-54 182.4 13.5 1.6 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 EWC44155.1 - 1.2e-51 175.5 0.1 2.3e-51 174.6 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CCCH_6 PF18585.1 EWC44155.1 - 1.5e-20 72.8 0.0 4e-20 71.4 0.0 1.8 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 EWC44155.1 - 9.5e-16 58.1 0.0 2.5e-15 56.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.29 EWC44155.1 - 1.6e-05 24.7 13.2 0.00024 20.9 5.3 3.2 2 1 0 2 2 2 2 PHD-finger ResIII PF04851.15 EWC44155.1 - 3.6e-05 23.8 0.0 9.6e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PHD_2 PF13831.6 EWC44155.1 - 0.0035 16.9 3.3 0.0035 16.9 3.3 3.1 4 1 0 4 4 4 1 PHD-finger C1_1 PF00130.22 EWC44155.1 - 0.17 11.8 10.1 0.1 12.5 3.1 2.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 EWC44155.1 - 3.2 7.8 7.0 1.3 9.1 3.4 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-CCCH_7 PF18586.1 EWC44155.1 - 5 7.5 6.1 1.4 9.3 0.6 2.6 1 1 1 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 MRP-S28 PF10213.9 EWC44156.1 - 2.6e-42 144.2 0.4 5.4e-42 143.2 0.4 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Glyco_tran_28_C PF04101.16 EWC44157.1 - 3e-22 79.4 0.1 3.7e-22 79.1 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Btz PF09405.10 EWC44158.1 - 2.3e-22 79.7 9.3 2.3e-22 79.7 9.3 2.2 2 1 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding Glyco_hydro_72 PF03198.14 EWC44160.1 - 7e-129 429.6 1.0 8.6e-129 429.3 1.0 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EWC44160.1 - 0.00023 20.7 0.2 0.00041 19.9 0.2 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF681 PF05080.12 EWC44160.1 - 0.037 14.7 0.0 0.097 13.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF681) Glyco_hydro_2_C PF02836.17 EWC44160.1 - 0.043 12.9 0.0 0.062 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_114 PF03537.13 EWC44161.1 - 3.4e-67 226.2 0.0 4e-67 225.9 0.0 1.0 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 Lactamase_B_2 PF12706.7 EWC44162.1 - 5.4e-23 81.6 0.0 1e-21 77.4 0.0 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EWC44162.1 - 2.5e-11 43.7 0.0 4.3e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EWC44162.1 - 0.00058 19.9 2.4 0.094 12.7 1.7 3.0 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily Tsi6 PF18660.1 EWC44163.1 - 0.17 12.0 3.1 0.46 10.6 3.1 1.7 1 0 0 1 1 1 0 Tsi6 NmrA PF05368.13 EWC44165.1 - 0.17 11.4 0.0 0.35 10.4 0.0 1.7 1 1 0 1 1 1 0 NmrA-like family Fungal_trans PF04082.18 EWC44167.1 - 1.1e-38 132.8 0.1 2.2e-38 131.9 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44167.1 - 9.3e-10 38.5 11.8 1.6e-09 37.8 11.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EWC44168.1 - 1.6e-17 63.5 39.9 2e-17 63.1 39.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CNOT11 PF10155.9 EWC44169.1 - 3.2e-14 53.2 0.0 5.9e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 Caprin-1_C PF12287.8 EWC44169.1 - 0.019 15.1 0.9 0.036 14.2 0.9 1.3 1 0 0 1 1 1 0 Cytoplasmic activation/proliferation-associated protein-1 C term Pmp3 PF01679.17 EWC44170.1 - 6.5e-24 83.9 8.3 7.2e-24 83.7 8.3 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Ribosomal_L22e PF01776.17 EWC44172.1 - 4.3e-46 155.8 0.3 5.4e-46 155.5 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Transketolase_N PF00456.21 EWC44173.1 - 5.2e-155 515.5 0.0 6.6e-155 515.1 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EWC44173.1 - 1.7e-48 164.6 0.0 2.8e-48 163.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EWC44173.1 - 4.6e-13 49.1 0.3 1.3e-12 47.7 0.0 2.0 3 0 0 3 3 3 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EWC44173.1 - 3.4e-07 29.7 0.0 6.4e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 EWC44173.1 - 0.036 13.0 0.0 0.066 12.2 0.0 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component Anp1 PF03452.14 EWC44174.1 - 9.3e-106 353.1 0.0 1.1e-105 352.8 0.0 1.0 1 0 0 1 1 1 1 Anp1 p450 PF00067.22 EWC44175.1 - 2.2e-23 82.7 0.0 4.9e-23 81.6 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 NAD_kinase PF01513.21 EWC44176.1 - 1.6e-80 270.4 0.0 2.2e-80 270.0 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase AA_permease_2 PF13520.6 EWC44177.1 - 6.2e-68 229.6 52.3 8.3e-68 229.2 52.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC44177.1 - 9.1e-14 50.9 45.2 1.4e-13 50.3 45.2 1.2 1 0 0 1 1 1 1 Amino acid permease IlvGEDA_leader PF08046.11 EWC44177.1 - 4.4 6.8 9.7 8.4 5.9 0.2 3.2 3 0 0 3 3 3 0 IlvGEDA operon leader peptide Cu-oxidase PF00394.22 EWC44178.1 - 1.8e-34 119.2 0.0 4.7e-32 111.3 0.0 2.2 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EWC44178.1 - 6e-29 100.5 0.1 6e-29 100.5 0.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EWC44178.1 - 5.2e-18 65.1 9.5 1.3e-16 60.6 1.6 3.3 2 1 0 2 2 2 2 Multicopper oxidase TOM6p PF15184.6 EWC44178.1 - 0.094 12.5 0.0 18 5.2 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial import receptor subunit TOM6 homolog Ribosomal_L7Ae PF01248.26 EWC44179.1 - 4e-18 64.9 0.3 2.4e-12 46.4 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CENP-N PF05238.13 EWC44179.1 - 0.098 11.9 9.1 0.13 11.5 9.1 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like CLN3 PF02487.17 EWC44179.1 - 0.21 10.6 1.0 0.31 10.0 1.0 1.2 1 0 0 1 1 1 0 CLN3 protein Tim54 PF11711.8 EWC44179.1 - 0.69 8.6 13.5 0.9 8.3 13.6 1.4 1 1 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 EWC44179.1 - 1.2 8.3 6.8 1.7 7.8 6.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SOBP PF15279.6 EWC44179.1 - 1.3 9.5 11.3 2.2 8.8 11.3 1.3 1 1 0 1 1 1 0 Sine oculis-binding protein DUF2151 PF10221.9 EWC44179.1 - 1.7 7.1 9.9 2.3 6.7 9.9 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Presenilin PF01080.17 EWC44179.1 - 3.1 6.4 8.9 4.3 6.0 8.9 1.3 1 0 0 1 1 1 0 Presenilin Paramyxo_ncap PF00973.19 EWC44179.1 - 5 5.9 7.5 6.6 5.5 7.5 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PTPA PF03095.15 EWC44180.1 - 5.8e-108 360.9 0.0 6.9e-108 360.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RNase_PH PF01138.21 EWC44181.1 - 1.6e-14 54.5 0.0 2.6e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Glyco_hydro_75 PF07335.11 EWC44182.1 - 2.1e-51 174.4 0.2 3.2e-51 173.8 0.2 1.3 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 TIMELESS PF04821.14 EWC44183.1 - 2.4e-67 227.1 0.0 9.4e-67 225.2 0.0 1.9 2 0 0 2 2 2 1 Timeless protein TIMELESS_C PF05029.13 EWC44183.1 - 3e-11 43.2 8.2 2.9e-10 39.9 8.2 2.1 1 1 0 1 1 1 1 Timeless protein C terminal region BPL_N PF09825.9 EWC44184.1 - 8.7e-114 380.5 0.0 1.1e-113 380.1 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EWC44184.1 - 8e-26 90.5 0.0 1.4e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EWC44184.1 - 7.9e-06 25.7 0.1 1.6e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain GATase_3 PF07685.14 EWC44184.1 - 0.16 11.6 0.0 0.34 10.5 0.0 1.5 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Pkinase PF00069.25 EWC44185.1 - 3.3e-50 170.9 0.1 8.1e-50 169.6 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44185.1 - 1.4e-22 80.2 0.0 2.6e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC44185.1 - 0.00097 19.1 0.1 0.0019 18.1 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EWC44185.1 - 0.002 17.7 0.3 0.0061 16.2 0.3 1.7 1 1 0 1 1 1 1 RIO1 family Paf67 PF10255.9 EWC44186.1 - 1.3e-153 511.8 0.0 1.5e-153 511.6 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EWC44186.1 - 0.0003 20.7 0.0 0.0013 18.7 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC44186.1 - 0.00031 20.4 0.0 0.0013 18.5 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC44186.1 - 0.011 16.3 0.0 11 6.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EWC44186.1 - 0.021 15.1 0.0 0.3 11.4 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Spt5_N PF11942.8 EWC44186.1 - 0.15 13.0 2.9 0.6 11.1 1.9 2.2 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal TANGO2 PF05742.12 EWC44187.1 - 5.1e-22 79.1 0.0 6e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 HRDC PF00570.23 EWC44187.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 HRDC domain PCI PF01399.27 EWC44188.1 - 4.9e-13 49.5 0.0 7.7e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 PCI domain DUF2779 PF11074.8 EWC44188.1 - 0.18 12.3 0.0 1.3 9.5 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) eIF-3c_N PF05470.12 EWC44189.1 - 1.2e-91 307.9 9.3 1.2e-91 307.9 9.3 3.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CDC45 PF02724.14 EWC44189.1 - 0.049 11.9 18.1 0.072 11.4 18.1 1.3 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EWC44189.1 - 3.9 6.8 31.5 3 7.2 30.1 1.4 1 1 0 1 1 1 0 SDA1 DEAD PF00270.29 EWC44190.1 - 1.2e-50 171.7 0.0 8e-50 169.0 0.0 1.9 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC44190.1 - 3.5e-15 56.3 0.0 3e-14 53.3 0.0 2.3 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC44190.1 - 9e-05 22.5 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EWC44190.1 - 0.018 15.4 0.0 7 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF5335 PF17269.2 EWC44190.1 - 0.09 12.6 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5335) FAT PF02259.23 EWC44191.1 - 1.8e-134 448.4 2.9 1.9e-134 448.3 0.1 2.3 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EWC44191.1 - 4e-72 243.0 0.2 7.9e-72 242.1 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EWC44191.1 - 1.2e-69 233.3 11.2 7.6e-65 217.7 0.4 5.8 5 1 1 6 6 6 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EWC44191.1 - 1.4e-45 153.7 0.1 1.4e-45 153.7 0.1 3.4 3 1 1 4 4 3 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 EWC44191.1 - 1.4e-17 63.8 14.6 0.0019 18.6 0.1 8.5 6 2 0 6 6 6 5 HEAT repeats HEAT PF02985.22 EWC44191.1 - 3.3e-16 58.0 22.9 0.015 15.5 0.0 11.9 11 0 0 11 11 11 3 HEAT repeat FATC PF02260.20 EWC44191.1 - 4.4e-15 55.2 0.7 1.3e-14 53.7 0.7 1.9 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.6 EWC44191.1 - 1.4e-11 44.6 35.1 1.9e-05 25.0 0.0 11.3 12 1 1 13 13 11 4 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EWC44191.1 - 1.5e-07 32.0 1.1 21 5.8 0.0 7.7 6 1 2 8 8 8 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EWC44191.1 - 6e-07 29.2 3.8 4.2 6.9 0.0 6.3 4 3 2 6 6 6 1 CLASP N terminal IFRD PF05004.13 EWC44191.1 - 7.2e-07 28.6 1.7 4.6 6.3 0.0 6.2 5 2 2 7 7 7 1 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 EWC44191.1 - 2.6e-05 24.3 3.2 0.44 10.6 0.1 5.7 3 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EWC44191.1 - 0.011 14.3 15.7 1.4 7.4 0.0 5.2 3 2 0 4 4 4 0 Adaptin N terminal region RICTOR_N PF14664.6 EWC44191.1 - 0.035 13.1 1.6 0.082 11.9 0.2 2.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term TPR_19 PF14559.6 EWC44191.1 - 0.047 14.2 1.4 1.1e+02 3.3 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Xpo1 PF08389.12 EWC44191.1 - 0.049 13.7 6.0 3.1 7.8 0.8 4.8 4 1 0 4 4 4 0 Exportin 1-like protein V-ATPase_H_N PF03224.14 EWC44191.1 - 0.063 12.6 2.4 4.4 6.5 0.0 4.0 4 0 0 4 4 4 0 V-ATPase subunit H Sec7_N PF12783.7 EWC44191.1 - 0.079 12.9 3.0 20 5.1 0.8 4.2 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal MOR2-PAG1_C PF14225.6 EWC44191.1 - 0.29 11.0 2.8 0.7 9.7 0.7 2.9 2 1 0 2 2 2 0 Cell morphogenesis C-terminal TIP120 PF08623.10 EWC44191.1 - 0.85 9.4 4.8 11 5.8 0.5 4.0 3 1 0 3 3 2 0 TATA-binding protein interacting (TIP20) TPR_2 PF07719.17 EWC44191.1 - 2 8.7 5.0 50 4.4 0.2 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat HEAT_PBS PF03130.16 EWC44191.1 - 3.9 8.4 12.5 2.7e+02 2.7 0.1 7.6 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Aquarius_N PF16399.5 EWC44192.1 - 3.5e-210 700.1 0.0 5.1e-210 699.6 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 EWC44192.1 - 6.9e-20 71.9 0.0 3.3e-19 69.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EWC44192.1 - 6.5e-13 48.7 0.0 1.9e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EWC44192.1 - 3.2e-06 27.2 0.0 6.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EWC44192.1 - 4.8e-06 26.4 0.0 0.003 17.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EWC44192.1 - 1.8e-05 25.1 0.0 3.9e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EWC44192.1 - 0.0026 18.2 3.3 0.031 14.7 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EWC44192.1 - 0.0033 17.8 0.0 0.014 15.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EWC44192.1 - 0.034 14.4 0.0 0.73 10.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain UvrD-helicase PF00580.21 EWC44192.1 - 0.038 13.5 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 EWC44192.1 - 0.14 11.3 0.0 4.3 6.4 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase DUF2075 PF09848.9 EWC44192.1 - 0.16 11.2 0.0 0.37 10.0 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Snf7 PF03357.21 EWC44193.1 - 2.8e-12 46.6 11.8 3.4e-12 46.3 11.8 1.1 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 EWC44193.1 - 0.006 16.5 2.4 0.0087 16.0 2.4 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway IML1 PF12257.8 EWC44193.1 - 0.008 15.3 1.5 0.0091 15.1 1.5 1.1 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 COG5 PF10392.9 EWC44193.1 - 0.12 12.6 2.9 0.19 11.9 1.9 1.9 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Ribosomal_S20p PF01649.18 EWC44193.1 - 0.32 11.6 8.9 0.97 10.1 5.8 2.3 1 1 1 2 2 2 0 Ribosomal protein S20 DUF948 PF06103.11 EWC44193.1 - 0.51 10.6 7.5 0.33 11.2 1.6 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) PspA_IM30 PF04012.12 EWC44193.1 - 3.1 7.3 15.0 19 4.8 15.0 2.2 1 1 0 1 1 1 0 PspA/IM30 family Homeodomain PF00046.29 EWC44194.1 - 4.1e-17 61.8 3.1 8.6e-17 60.7 3.1 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EWC44194.1 - 0.12 12.3 0.1 0.12 12.3 0.1 2.3 2 0 0 2 2 2 0 Homeobox KN domain ADH_zinc_N PF00107.26 EWC44195.1 - 5.8e-09 36.0 0.0 8.7e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Amidase PF01425.21 EWC44196.1 - 3e-26 92.4 0.0 3.5e-26 92.2 0.0 1.0 1 0 0 1 1 1 1 Amidase dCMP_cyt_deam_1 PF00383.23 EWC44197.1 - 1.1e-22 79.8 0.1 1.6e-22 79.3 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EWC44197.1 - 1.1e-18 67.3 0.0 1.6e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EWC44197.1 - 0.0016 18.6 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EWC44197.1 - 0.041 14.0 0.0 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 APOBEC3 APOBEC2 PF18772.1 EWC44197.1 - 0.081 13.0 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 APOBEC2 APOBEC_N PF08210.11 EWC44197.1 - 0.082 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain NAD1 PF18778.1 EWC44197.1 - 0.092 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Bd3614-deam PF14439.6 EWC44197.1 - 0.16 12.1 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase PFK PF00365.20 EWC44198.1 - 3.1e-187 620.6 0.8 1.4e-101 339.5 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase Pfk_N PF18468.1 EWC44198.1 - 4.1e-07 30.3 0.0 1.1e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 Phosphofructokinase N-terminal domain yeast UVR PF02151.19 EWC44198.1 - 0.074 12.8 1.2 0.2 11.5 1.2 1.8 1 0 0 1 1 1 0 UvrB/uvrC motif TgMIC1 PF11476.8 EWC44198.1 - 0.19 11.4 0.8 2.4 7.9 0.0 2.3 2 0 0 2 2 2 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Transket_pyr PF02779.24 EWC44199.1 - 2.9e-41 141.1 0.0 3.4e-40 137.6 0.0 2.0 1 1 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EWC44199.1 - 6.3e-35 119.8 0.0 7.3e-34 116.3 0.0 2.3 2 0 0 2 2 2 1 Transketolase, C-terminal domain RRM_1 PF00076.22 EWC44200.1 - 1.7e-09 37.4 0.0 2.8e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC44200.1 - 0.0014 18.5 0.0 0.0026 17.6 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EWC44200.1 - 0.019 15.0 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EWC44200.1 - 0.028 14.4 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif FoP_duplication PF13865.6 EWC44200.1 - 3.8 8.1 8.5 8.4 7.0 8.5 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Sterol_MT_C PF08498.10 EWC44201.1 - 4.4e-28 97.4 0.1 8.4e-28 96.5 0.1 1.5 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EWC44201.1 - 1.5e-18 67.2 0.0 2.7e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44201.1 - 1.4e-17 63.9 0.0 2e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44201.1 - 1.7e-17 63.9 0.0 3.3e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EWC44201.1 - 1e-12 47.9 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EWC44201.1 - 6.5e-11 42.9 0.0 1.5e-10 41.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC44201.1 - 9.9e-11 41.7 0.0 1.6e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC44201.1 - 1.1e-08 34.7 0.0 1.7e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EWC44201.1 - 0.00053 19.8 0.0 0.00086 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.17 EWC44201.1 - 0.0016 17.6 0.0 0.0026 16.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_15 PF09445.10 EWC44201.1 - 0.0033 17.0 0.0 0.0048 16.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 EWC44201.1 - 0.0045 16.6 0.0 0.0085 15.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EWC44201.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 EWC44201.1 - 0.013 15.4 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 EWC44201.1 - 0.05 13.2 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_2 PF00891.18 EWC44201.1 - 0.083 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_4 PF02390.17 EWC44201.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase MetW PF07021.12 EWC44201.1 - 0.1 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_24 PF13578.6 EWC44201.1 - 0.14 13.2 0.0 0.43 11.6 0.0 1.8 2 0 0 2 2 1 0 Methyltransferase domain PEGSRP PF07623.11 EWC44201.1 - 0.19 11.6 0.0 0.39 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1584) RAC_head PF16717.5 EWC44202.1 - 1.6e-24 86.7 1.8 1.6e-24 86.7 1.8 2.9 3 1 0 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 EWC44202.1 - 4.2e-15 55.6 0.1 1.3e-10 41.2 0.1 3.1 2 0 0 2 2 2 2 DnaJ domain V_ATPase_I PF01496.19 EWC44202.1 - 1.8 6.4 6.3 2.4 6.0 6.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 EWC44202.1 - 3.1 6.5 6.2 6.5 5.4 6.2 1.6 1 0 0 1 1 1 0 Presenilin LMBR1 PF04791.16 EWC44202.1 - 9.7 5.0 7.1 14 4.5 7.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2781 PF10914.8 EWC44203.1 - 2e-29 102.9 8.1 2.3e-29 102.7 8.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Nepo_coat_N PF03689.15 EWC44203.1 - 0.086 12.8 0.0 0.75 9.8 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain Adhesin_P1 PF03257.13 EWC44204.1 - 0.024 15.2 2.9 0.062 13.8 2.9 1.7 1 0 0 1 1 1 0 Mycoplasma adhesin P1 PI3_PI4_kinase PF00454.27 EWC44205.1 - 3.2e-55 187.7 0.0 6.1e-55 186.7 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 EWC44205.1 - 1.2e-26 92.6 0.5 4.4e-25 87.6 0.0 3.6 3 1 1 4 4 4 1 UME (NUC010) domain FAT PF02259.23 EWC44205.1 - 5.4e-26 91.6 0.2 1.2e-25 90.5 0.2 1.6 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 EWC44205.1 - 8.3e-17 60.7 0.2 2.7e-16 59.1 0.2 2.0 1 0 0 1 1 1 1 FATC domain ISN1 PF06437.11 EWC44206.1 - 8.7e-173 574.9 0.0 9.8e-173 574.8 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Swi3 PF07962.12 EWC44207.1 - 4.5e-33 113.1 0.1 1.5e-32 111.4 0.1 1.8 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 Nnf1 PF03980.14 EWC44207.1 - 0.74 10.2 5.2 0.8 10.1 2.5 2.4 2 1 0 2 2 2 0 Nnf1 GET2 PF08690.10 EWC44207.1 - 1.1 8.8 5.9 1.6 8.3 5.9 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Adaptin_binding PF10199.9 EWC44207.1 - 2.2 8.9 9.9 2.4 8.8 7.6 2.3 1 1 1 2 2 2 0 Alpha and gamma adaptin binding protein p34 FMN_dh PF01070.18 EWC44208.1 - 2.1e-120 402.0 0.4 2.5e-120 401.7 0.4 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EWC44208.1 - 2.3e-22 78.9 0.0 4.3e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EWC44208.1 - 2.1e-08 33.7 0.1 3.3e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EWC44208.1 - 1.8e-05 24.3 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EWC44208.1 - 3.6e-05 22.9 0.7 0.00011 21.3 0.2 1.8 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EWC44208.1 - 0.0061 16.0 0.2 0.25 10.8 0.0 2.4 2 0 0 2 2 2 1 Histidine biosynthesis protein G3P_antiterm PF04309.12 EWC44208.1 - 0.04 13.3 0.0 4.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator ThiG PF05690.14 EWC44208.1 - 0.057 12.7 0.2 0.74 9.1 0.0 2.1 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG TFIIF_alpha PF05793.12 EWC44209.1 - 0.00037 19.2 98.6 0.0015 17.2 2.5 5.2 1 1 2 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3439 PF11921.8 EWC44209.1 - 0.011 15.7 8.4 0.025 14.6 8.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 EWC44209.1 - 0.27 9.4 7.5 0.58 8.3 7.5 1.5 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Med17 PF10156.9 EWC44210.1 - 3.3e-72 243.7 1.4 4.3e-72 243.3 1.4 1.2 1 0 0 1 1 1 1 Subunit 17 of Mediator complex DASH_Hsk3 PF08227.11 EWC44210.1 - 2.2e-18 66.3 6.5 4.5e-18 65.3 6.5 1.6 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Inhibitor_I71 PF12628.7 EWC44210.1 - 0.0074 16.2 0.2 0.012 15.5 0.2 1.2 1 0 0 1 1 1 1 Falstatin, cysteine peptidase inhibitor BTV_NS2 PF04514.12 EWC44210.1 - 0.047 12.5 1.1 0.07 12.0 1.1 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 TRAP_alpha PF03896.16 EWC44210.1 - 0.41 9.8 2.5 0.64 9.2 2.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4407 PF14362.6 EWC44210.1 - 3.6 6.9 9.9 6.8 5.9 9.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DSHCT PF08148.12 EWC44211.1 - 2.1e-53 180.4 0.3 6.1e-53 178.8 0.3 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EWC44211.1 - 1.9e-31 108.7 0.1 4e-31 107.6 0.1 1.6 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 EWC44211.1 - 4.7e-26 92.3 0.4 7e-26 91.7 0.4 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 EWC44211.1 - 2.1e-18 66.7 0.0 4e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC44211.1 - 5.7e-07 29.9 0.0 1.6e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC44211.1 - 4e-05 23.7 0.0 0.00011 22.2 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3516 PF12029.8 EWC44211.1 - 0.095 11.8 1.4 1.4 7.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3516) IBN_N PF03810.19 EWC44212.1 - 3.6e-16 58.8 0.7 2.7e-15 56.0 0.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 EWC44212.1 - 8.4e-11 41.3 0.4 8.4e-11 41.3 0.4 1.8 2 0 0 2 2 2 1 Cse1 HEAT_2 PF13646.6 EWC44212.1 - 0.0051 17.2 0.1 0.48 10.9 0.1 3.8 3 1 0 4 4 4 1 HEAT repeats Xpo1 PF08389.12 EWC44212.1 - 0.019 15.0 5.3 0.11 12.5 0.0 4.1 4 0 0 4 4 4 0 Exportin 1-like protein Cnd1 PF12717.7 EWC44212.1 - 0.023 14.8 1.9 0.081 13.0 0.7 2.6 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EWC44212.1 - 0.098 12.8 0.4 0.83 9.9 0.1 2.9 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 EWC44212.1 - 0.45 10.9 2.5 20 5.8 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat BUD22 PF09073.10 EWC44212.1 - 5.5 6.2 10.4 13 5.0 0.0 2.2 2 0 0 2 2 2 0 BUD22 Importin_rep_6 PF18829.1 EWC44212.1 - 6.8 6.9 7.7 0.53 10.4 0.1 3.1 2 0 0 2 2 2 0 Importin repeat 6 CBFD_NFYB_HMF PF00808.23 EWC44213.1 - 4.9e-20 71.6 1.3 4.9e-20 71.6 1.3 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EWC44213.1 - 1.7e-05 25.2 0.7 9.3e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 PrkA PF06798.12 EWC44213.1 - 0.0008 19.1 1.2 0.00095 18.9 1.2 1.1 1 0 0 1 1 1 1 PrkA serine protein kinase C-terminal domain Bromo_TP PF07524.13 EWC44213.1 - 0.038 14.0 0.1 0.086 12.9 0.0 1.6 1 1 1 2 2 2 0 Bromodomain associated Actin PF00022.19 EWC44214.1 - 1.3e-92 310.6 0.0 1.4e-91 307.1 0.0 1.9 1 1 0 1 1 1 1 Actin Pribosyltran PF00156.27 EWC44215.1 - 3.7e-07 29.8 0.0 6.3e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF383 PF04063.14 EWC44216.1 - 1.5e-59 200.9 0.1 3.9e-59 199.5 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EWC44216.1 - 1.3e-19 69.8 3.7 3.3e-19 68.5 1.8 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF384) Peptidase_C50 PF03568.17 EWC44216.1 - 0.00039 19.6 0.1 0.0013 17.9 0.0 1.6 1 1 1 2 2 2 1 Peptidase family C50 MlaA PF04333.13 EWC44216.1 - 0.049 13.3 0.0 0.1 12.3 0.0 1.5 1 1 0 1 1 1 0 MlaA lipoprotein ATP-grasp_2 PF08442.10 EWC44217.1 - 4.8e-75 251.6 0.5 4.8e-75 251.6 0.5 1.5 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EWC44217.1 - 1.3e-26 93.3 0.2 2.7e-26 92.2 0.2 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EWC44217.1 - 1.4e-08 34.5 0.5 3.8e-08 33.1 0.1 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EWC44217.1 - 0.00053 19.8 1.1 0.0041 16.9 0.1 2.5 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF3245 PF11595.8 EWC44218.1 - 1.7e-14 54.5 4.1 1.7e-14 54.5 4.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3245) SRP72 PF08492.12 EWC44218.1 - 0.01 16.2 0.8 0.01 16.2 0.8 3.5 2 1 1 3 3 3 0 SRP72 RNA-binding domain HSF_DNA-bind PF00447.17 EWC44219.1 - 6.2e-31 106.9 1.0 1.4e-30 105.7 1.0 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding DUF4795 PF16043.5 EWC44219.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) F-box PF00646.33 EWC44220.1 - 7e-10 38.5 0.5 2.3e-09 36.9 0.4 1.9 1 1 1 2 2 2 1 F-box domain F-box-like PF12937.7 EWC44220.1 - 2.1e-07 30.8 0.5 3.7e-07 29.9 0.5 1.5 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EWC44220.1 - 0.0038 17.1 0.0 0.0078 16.1 0.0 1.5 1 0 0 1 1 1 1 F-box SMC_Nse1 PF07574.13 EWC44221.1 - 7.5e-53 179.3 0.0 1.1e-52 178.8 0.0 1.3 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EWC44221.1 - 6.3e-11 42.4 12.1 1.2e-10 41.5 12.1 1.5 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H_2 PF13832.6 EWC44221.1 - 0.00015 21.9 3.7 0.00028 21.0 3.7 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EWC44221.1 - 0.00016 21.8 1.9 0.00033 20.9 1.9 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-RING_2 PF13639.6 EWC44221.1 - 0.049 14.0 10.8 0.088 13.2 10.8 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.6 EWC44221.1 - 6 6.7 7.3 12 5.7 7.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Bystin PF05291.11 EWC44222.1 - 1.5e-136 454.4 0.0 1.9e-136 454.1 0.0 1.1 1 0 0 1 1 1 1 Bystin CCDC158 PF15921.5 EWC44223.1 - 2 6.2 5.2 2.7 5.7 5.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Sec63 PF02889.16 EWC44224.1 - 5.2e-133 442.0 0.0 5.7e-80 268.2 0.3 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EWC44224.1 - 4.2e-50 169.9 0.0 3e-26 92.3 0.2 3.5 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 EWC44224.1 - 1.6e-22 80.3 0.0 2.6e-12 47.1 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EWC44224.1 - 3.5e-16 59.5 0.0 3.2e-06 27.5 0.0 3.8 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EWC44224.1 - 1.8e-08 34.8 0.2 0.0039 17.5 0.0 3.9 3 2 0 3 3 3 2 AAA domain Helicase_PWI PF18149.1 EWC44224.1 - 2.3e-06 27.7 0.0 7.4e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA_30 PF13604.6 EWC44224.1 - 2.5e-06 27.4 0.0 0.016 14.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EWC44224.1 - 0.0001 22.7 0.2 0.17 12.2 0.3 2.8 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EWC44224.1 - 0.0011 19.4 0.4 0.54 10.7 0.0 3.9 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EWC44224.1 - 0.004 16.2 0.0 0.16 11.0 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 EWC44224.1 - 0.021 14.5 0.2 11 5.7 0.0 3.6 5 0 0 5 5 5 0 IstB-like ATP binding protein DEK_C PF08766.11 EWC44224.1 - 0.029 14.3 0.1 0.089 12.7 0.1 1.9 1 0 0 1 1 1 0 DEK C terminal domain TniB PF05621.11 EWC44224.1 - 0.094 12.1 0.5 18 4.7 0.1 3.9 5 0 0 5 5 5 0 Bacterial TniB protein AAA_7 PF12775.7 EWC44224.1 - 0.16 11.5 0.1 2.9 7.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region PAP_assoc PF03828.19 EWC44225.1 - 2e-18 66.4 0.3 6.6e-18 64.7 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EWC44225.1 - 1.9e-05 24.9 0.0 4.2e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EWC44225.1 - 0.17 12.0 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Bud13 PF09736.9 EWC44226.1 - 3.3e-44 150.8 3.1 3.3e-44 150.8 3.1 1.6 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex Nop16 PF09420.10 EWC44226.1 - 0.0038 17.3 5.8 0.0053 16.8 5.8 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 DUF4715 PF15835.5 EWC44226.1 - 0.9 9.6 5.1 2.5 8.1 4.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4715) CRF PF00473.17 EWC44226.1 - 7.7 6.7 7.1 48 4.1 7.1 2.4 1 1 0 1 1 1 0 Corticotropin-releasing factor family Sterile PF03015.19 EWC44229.1 - 0.0084 16.3 0.2 4.1 7.7 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein Pro_CA PF00484.19 EWC44230.1 - 4.3e-49 166.8 0.1 5.6e-49 166.4 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase BCS1_N PF08740.11 EWC44231.1 - 1.1e-36 126.6 6.9 2.8e-36 125.3 6.9 1.7 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EWC44231.1 - 2.6e-19 69.9 0.0 6.3e-19 68.7 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC44231.1 - 0.0064 16.9 0.2 0.074 13.4 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EWC44231.1 - 0.0091 15.2 0.0 1.8 7.7 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF815) AAA_25 PF13481.6 EWC44231.1 - 0.012 15.2 0.0 0.038 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain ANAPC4 PF12896.7 EWC44231.1 - 0.063 12.8 0.0 0.26 10.8 0.1 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 IstB_IS21 PF01695.17 EWC44231.1 - 0.068 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EWC44231.1 - 0.1 13.2 0.0 0.52 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EWC44231.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 EWC44231.1 - 0.17 11.7 0.0 0.96 9.2 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain DHC PF09626.10 EWC44231.1 - 0.17 12.7 0.7 0.41 11.5 0.7 1.6 1 0 0 1 1 1 0 Dihaem cytochrome c Sld5 PF05916.11 EWC44232.1 - 5.1e-09 36.6 0.0 5.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein Sod_Fe_C PF02777.18 EWC44233.1 - 3.5e-37 126.7 0.3 6.4e-37 125.8 0.3 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EWC44233.1 - 8.9e-31 106.2 0.9 1.5e-30 105.5 0.9 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DnaJ PF00226.31 EWC44235.1 - 2.9e-28 97.8 2.7 5.2e-28 97.0 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EWC44235.1 - 9.2e-28 97.2 0.7 1.3e-27 96.7 0.7 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain CENP-T_C PF15511.6 EWC44236.1 - 0.12 12.5 0.1 0.32 11.1 0.1 1.7 1 1 1 2 2 2 0 Centromere kinetochore component CENP-T histone fold Forkhead_N PF08430.12 EWC44239.1 - 0.22 12.1 9.9 0.69 10.5 9.9 1.9 1 0 0 1 1 1 0 Forkhead N-terminal region DUF676 PF05057.14 EWC44240.1 - 2.4e-05 24.0 0.0 3.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EWC44240.1 - 0.00011 22.0 0.0 0.00059 19.6 0.0 1.9 1 1 1 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EWC44240.1 - 0.00024 21.8 4.9 0.00039 21.1 4.5 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC44240.1 - 0.00092 18.5 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 EWC44240.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 EWC44240.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Amidohydro_2 PF04909.14 EWC44243.1 - 1.4e-15 57.9 0.3 4e-15 56.4 0.3 1.9 1 1 0 1 1 1 1 Amidohydrolase MMR_HSR1_C PF08438.10 EWC44244.1 - 1.2e-33 116.0 0.0 2.1e-33 115.3 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EWC44244.1 - 6.6e-21 74.5 0.0 5.6e-20 71.5 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EWC44244.1 - 8.5e-11 41.6 0.0 4.5e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Dynamin_N PF00350.23 EWC44244.1 - 0.011 15.8 1.0 0.023 14.7 0.2 2.0 3 0 0 3 3 3 0 Dynamin family RsgA_GTPase PF03193.16 EWC44244.1 - 0.037 13.9 0.2 3.5 7.5 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AIG1 PF04548.16 EWC44244.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 AIG1 family AAA_28 PF13521.6 EWC44244.1 - 0.12 12.6 0.0 0.79 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 EWC44244.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 GTP_EFTU PF00009.27 EWC44244.1 - 0.15 11.6 0.2 1.9 8.0 0.0 2.4 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain MFS_1 PF07690.16 EWC44245.1 - 2.9e-06 26.5 33.2 0.00017 20.7 25.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Abhydrolase_9_N PF15420.6 EWC44245.1 - 0.01 15.8 2.2 0.047 13.7 0.1 2.5 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus DUF962 PF06127.11 EWC44245.1 - 0.057 13.5 0.3 0.38 10.9 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF962) OST3_OST6 PF04756.13 EWC44245.1 - 0.64 9.3 3.8 0.17 11.2 0.2 1.9 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family ECH_1 PF00378.20 EWC44246.1 - 1.3e-52 178.6 0.0 1.9e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EWC44246.1 - 3e-24 86.2 0.0 2.9e-21 76.3 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EWC44246.1 - 0.0004 20.3 0.0 1 9.3 0.0 2.2 2 0 0 2 2 2 2 Peptidase family S49 DUF3074 PF11274.8 EWC44249.1 - 6.1e-32 111.1 0.0 8e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Lactonase PF10282.9 EWC44250.1 - 6.6e-76 255.8 0.0 8.5e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Pox_I3 PF04661.12 EWC44250.1 - 0.029 13.5 0.0 0.043 12.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus I3 ssDNA-binding protein PNGaseA PF12222.8 EWC44252.1 - 1.8e-115 386.3 0.8 2.5e-115 385.8 0.8 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Cellulase PF00150.18 EWC44253.1 - 9.7e-45 153.2 2.5 1.5e-44 152.6 2.5 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF3615 PF12274.8 EWC44253.1 - 0.15 12.6 0.0 0.28 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3615) DUF2721 PF11026.8 EWC44254.1 - 2.3 8.1 6.8 4.3 7.2 6.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Methyltransf_23 PF13489.6 EWC44255.1 - 8.3e-20 71.3 0.0 1.1e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44255.1 - 7.2e-13 49.1 0.0 1.9e-12 47.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC44255.1 - 6.8e-10 39.5 0.0 1.3e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44255.1 - 2.6e-08 33.8 0.0 0.0015 18.4 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EWC44255.1 - 2.1e-07 31.6 0.0 2e-06 28.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC44255.1 - 0.00013 21.4 0.0 0.0035 16.7 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EWC44255.1 - 0.0077 16.0 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_4 PF02390.17 EWC44255.1 - 0.0093 15.5 0.1 0.035 13.6 0.0 1.9 2 1 0 2 2 2 1 Putative methyltransferase PrmA PF06325.13 EWC44255.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EWC44255.1 - 0.019 14.5 0.0 0.046 13.3 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain FtsJ PF01728.19 EWC44255.1 - 0.026 14.7 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EWC44255.1 - 0.034 13.5 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain DUF938 PF06080.12 EWC44255.1 - 0.11 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_2 PF00891.18 EWC44256.1 - 1.9e-20 73.1 0.0 5.6e-20 71.5 0.0 1.7 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EWC44256.1 - 0.00018 22.1 0.0 0.0023 18.6 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 EWC44256.1 - 0.007 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Sigma70_r4 PF04545.16 EWC44256.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DUF1180 PF06679.12 EWC44257.1 - 1.9 8.9 8.0 2.3 8.6 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Fungal_trans_2 PF11951.8 EWC44258.1 - 3e-09 36.2 0.1 4.2e-09 35.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44258.1 - 2.1e-07 31.0 7.5 3.5e-07 30.2 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cellulase PF00150.18 EWC44259.1 - 6.2e-11 42.2 0.0 8.9e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) HpcH_HpaI PF03328.14 EWC44260.1 - 1.9e-35 122.0 0.0 1.2e-18 67.1 0.0 2.1 1 1 1 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EWC44260.1 - 8.7e-14 51.4 0.0 1.1e-05 24.8 0.0 2.9 2 1 1 3 3 3 2 C-C_Bond_Lyase of the TIM-Barrel fold PEPcase PF00311.17 EWC44260.1 - 0.094 10.8 0.0 0.14 10.2 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Glyco_hydro_18 PF00704.28 EWC44261.1 - 2.2e-13 50.7 0.0 4.3e-13 49.7 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 p450 PF00067.22 EWC44262.1 - 1.7e-47 162.3 0.0 2.3e-47 161.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.13 EWC44263.1 - 2.9e-78 262.2 10.9 3.9e-78 261.8 10.9 1.2 1 0 0 1 1 1 1 RTA1 like protein Catalase PF00199.19 EWC44264.1 - 4.2e-24 85.4 0.0 6.5e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Catalase UPF0182 PF03699.13 EWC44265.1 - 1.5 6.8 4.8 2.1 6.4 4.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Ceramidase_alk PF04734.13 EWC44267.1 - 5.3e-219 728.0 0.0 6.3e-219 727.8 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EWC44267.1 - 1.2e-58 197.7 0.0 1.9e-58 197.0 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal DUF4165 PF13752.6 EWC44267.1 - 0.08 12.9 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4165) GST_C_2 PF13410.6 EWC44269.1 - 6.2e-11 42.2 0.0 1.5e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EWC44269.1 - 3.2e-06 27.2 0.0 1.5e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EWC44269.1 - 5.8e-06 26.0 0.0 1.3e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EWC44269.1 - 7e-06 26.2 0.0 1.5e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EWC44269.1 - 0.0017 18.7 0.0 0.0037 17.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain CMD PF02627.20 EWC44270.1 - 0.17 12.0 1.3 0.74 9.9 0.0 2.2 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Pkinase PF00069.25 EWC44271.1 - 9.6e-09 35.0 0.0 2.5e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44271.1 - 0.0086 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CTP_transf_like PF01467.26 EWC44272.1 - 8.6e-24 84.4 0.0 2.8e-20 73.0 0.0 2.5 2 0 0 2 2 2 2 Cytidylyltransferase-like IBR PF01485.21 EWC44272.1 - 5e-12 45.9 44.1 4.1e-06 26.9 13.2 3.7 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain BET PF17035.5 EWC44273.1 - 0.016 15.4 0.1 0.18 12.0 0.0 2.1 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation CSTF2_hinge PF14327.6 EWC44273.1 - 0.087 13.3 1.8 0.9 10.0 0.1 2.3 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 Polysacc_deac_1 PF01522.21 EWC44274.1 - 8.5e-28 96.7 0.0 2.2e-27 95.4 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EWC44274.1 - 0.019 15.4 2.1 0.019 15.4 2.1 1.6 2 0 0 2 2 2 0 Chitin recognition protein Glyco_hydro_57 PF03065.15 EWC44274.1 - 0.15 11.2 0.0 0.46 9.6 0.0 1.8 1 1 0 1 1 1 0 Glycosyl hydrolase family 57 DAGK_cat PF00781.24 EWC44275.1 - 1.2e-11 44.3 0.0 1.9e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain D-ser_dehydrat PF14031.6 EWC44276.1 - 2e-23 82.8 0.2 6.9e-23 81.1 0.0 1.9 2 0 0 2 2 2 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EWC44276.1 - 8e-18 64.9 0.0 1.2e-17 64.4 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain FliE PF02049.18 EWC44276.1 - 0.14 12.3 0.6 0.29 11.3 0.6 1.5 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE MeaB PF03308.16 EWC44277.1 - 0.00012 21.2 0.0 0.00018 20.6 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB KAP_NTPase PF07693.14 EWC44277.1 - 0.00017 20.9 0.0 0.00017 20.9 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain PRK PF00485.18 EWC44277.1 - 0.0018 18.0 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 EWC44277.1 - 0.0032 17.9 0.0 0.0046 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EWC44277.1 - 0.0032 16.8 0.0 0.0047 16.2 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 EWC44277.1 - 0.012 15.3 0.1 0.099 12.4 0.0 2.4 3 0 0 3 3 3 0 P-loop containing region of AAA domain SRP54 PF00448.22 EWC44277.1 - 0.013 15.1 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 EWC44277.1 - 0.019 14.9 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DUF463 PF04317.12 EWC44277.1 - 0.029 13.3 0.0 0.039 12.9 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 Torsin PF06309.11 EWC44277.1 - 0.029 14.5 0.0 0.071 13.2 0.0 1.7 1 0 0 1 1 1 0 Torsin FtsK_SpoIIIE PF01580.18 EWC44277.1 - 0.045 13.1 0.0 0.082 12.2 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Virul_Fac PF10139.9 EWC44277.1 - 0.045 12.0 0.0 0.06 11.6 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor AAA_18 PF13238.6 EWC44277.1 - 0.046 14.3 0.0 0.1 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EWC44277.1 - 0.053 13.7 0.2 0.13 12.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 EWC44277.1 - 0.054 12.9 0.0 0.086 12.3 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain APS_kinase PF01583.20 EWC44277.1 - 0.072 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase CbiA PF01656.23 EWC44277.1 - 0.097 12.7 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 EWC44277.1 - 0.16 11.9 0.0 0.47 10.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EWC44277.1 - 0.17 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 EWC44277.1 - 0.2 11.1 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Glyco_transf_92 PF01697.27 EWC44278.1 - 3.9e-14 52.9 0.4 4.7e-14 52.7 0.4 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 EWC44278.1 - 4.2e-08 33.6 0.2 7.5e-08 32.8 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 F-box-like PF12937.7 EWC44279.1 - 0.017 15.0 0.3 0.056 13.3 0.0 2.1 2 0 0 2 2 2 0 F-box-like Glyco_hydro_10 PF00331.20 EWC44280.1 - 1.5e-91 306.9 0.1 1.8e-91 306.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 DUF3209 PF11483.8 EWC44283.1 - 0.16 12.5 0.1 0.31 11.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3209) C2 PF00168.30 EWC44284.1 - 2.6e-10 40.5 0.0 5e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain PEP_mutase PF13714.6 EWC44285.1 - 1.5e-59 201.4 0.5 1.7e-59 201.2 0.5 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase TetR_C_11 PF16859.5 EWC44285.1 - 0.024 14.9 0.3 0.051 13.9 0.3 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AP_endonuc_2 PF01261.24 EWC44285.1 - 0.11 11.9 0.1 0.28 10.6 0.0 1.7 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Ferric_reduct PF01794.19 EWC44287.1 - 1.1e-15 57.9 8.3 2.2e-15 56.9 8.3 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EWC44287.1 - 3.2e-13 50.1 0.0 1.2e-05 25.5 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EWC44287.1 - 1.5e-08 34.7 0.0 3.5e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EWC44287.1 - 2.9e-06 27.9 0.0 5.5e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF2871 PF11070.8 EWC44287.1 - 2.1 8.6 4.9 51 4.2 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2871) DcpS_C PF11969.8 EWC44289.1 - 3.7e-17 62.8 2.2 1.9e-07 31.6 0.0 2.5 3 0 0 3 3 3 2 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.5 EWC44289.1 - 3.9e-14 52.9 0.0 9.3e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 EWC44289.1 - 1.7e-12 47.9 0.3 6.2e-12 46.1 0.3 1.9 1 1 0 1 1 1 1 HIT domain zf-BED PF02892.15 EWC44289.1 - 0.16 12.0 0.1 0.16 12.0 0.1 2.0 2 0 0 2 2 2 0 BED zinc finger mIF3 PF14877.6 EWC44290.1 - 0.012 15.3 0.1 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial translation initiation factor HSP70 PF00012.20 EWC44291.1 - 1.3e-10 40.2 0.0 1.8e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein DUF4957 PF16318.5 EWC44292.1 - 0.00077 19.4 0.7 0.0031 17.4 0.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4957) RHS_repeat PF05593.14 EWC44292.1 - 0.02 15.4 26.0 0.037 14.6 0.8 6.0 8 0 0 8 8 8 0 RHS Repeat DUF4595 PF15283.6 EWC44292.1 - 0.74 9.8 6.6 2.6 8.1 1.6 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4595) with porin-like fold SpvB PF03534.13 EWC44293.1 - 2e-104 348.8 0.0 3.2e-104 348.2 0.0 1.3 1 0 0 1 1 1 1 Salmonella virulence plasmid 65kDa B protein TcdB_toxin_midN PF12256.8 EWC44293.1 - 7.6e-34 116.6 3.7 2e-25 89.2 0.0 6.3 5 2 2 7 7 7 4 Insecticide toxin TcdB middle/N-terminal region TcdB_toxin_midC PF12255.8 EWC44293.1 - 1.5e-27 96.5 0.1 3.3e-27 95.4 0.1 1.5 1 0 0 1 1 1 1 Insecticide toxin TcdB middle/C-terminal region VCBS PF13517.6 EWC44293.1 - 1.5e-12 47.9 15.0 6e-07 29.9 2.7 4.9 2 2 4 6 6 6 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EWC44293.1 - 0.017 15.3 13.6 2.2 8.5 2.1 4.5 4 0 0 4 4 4 0 FG-GAP repeat RHS_repeat PF05593.14 EWC44293.1 - 0.031 14.8 4.4 5.7 7.6 0.0 4.7 5 0 0 5 5 5 0 RHS Repeat CathepsinC_exc PF08773.11 EWC44294.1 - 0.077 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Cathepsin C exclusion domain Sacchrp_dh_C PF16653.5 EWC44295.1 - 0.021 15.0 0.6 1.1 9.3 0.2 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase C-terminal domain NnrS PF05940.12 EWC44295.1 - 0.88 8.9 2.2 1.3 8.4 2.2 1.1 1 0 0 1 1 1 0 NnrS protein ATP_transf PF09830.9 EWC44296.1 - 7e-12 45.3 0.1 1.3e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase Ion_trans_2 PF07885.16 EWC44297.1 - 7.9e-28 96.2 26.6 5.6e-17 61.5 5.2 3.7 3 1 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EWC44297.1 - 0.012 14.9 15.8 0.036 13.3 5.3 2.4 2 1 0 2 2 2 0 Ion transport protein EXS PF03124.14 EWC44297.1 - 0.13 11.6 7.9 0.88 8.8 0.1 2.3 2 0 0 2 2 2 0 EXS family Lig_chan PF00060.26 EWC44297.1 - 0.42 10.4 14.5 0.019 14.8 5.1 2.9 2 1 0 2 2 2 0 Ligand-gated ion channel DUF2976 PF11190.8 EWC44297.1 - 0.97 9.3 3.7 4.1 7.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) DUF2721 PF11026.8 EWC44297.1 - 1.3 9.0 0.0 1.3 9.0 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) Spo7 PF03907.13 EWC44297.1 - 2.7 7.4 4.4 6.9 6.1 2.9 2.1 2 0 0 2 2 2 0 Spo7-like protein MFS_1 PF07690.16 EWC44298.1 - 7.7e-20 71.1 36.5 7.7e-20 71.1 36.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC44298.1 - 0.0021 17.0 9.7 0.0021 17.0 9.7 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter Nucleotid_trans PF03407.16 EWC44299.1 - 3.6e-14 53.2 0.4 3.6e-14 53.2 0.4 1.8 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase FAD_binding_4 PF01565.23 EWC44300.1 - 2.5e-23 82.3 1.0 4e-23 81.7 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EWC44300.1 - 2.1e-05 24.5 0.4 6e-05 23.1 0.4 1.7 1 0 0 1 1 1 1 Berberine and berberine like Peptidase_S8 PF00082.22 EWC44301.1 - 0.0087 15.3 0.0 0.015 14.6 0.0 1.3 1 1 0 1 1 1 1 Subtilase family Fungal_lectin_2 PF18647.1 EWC44302.1 - 9.5e-08 32.4 0.1 9.5e-08 32.4 0.1 2.2 3 0 0 3 3 2 1 Alpha-galactosyl-binding fungal lectin SPX PF03105.19 EWC44302.1 - 0.069 13.1 19.1 0.12 12.3 19.1 1.3 1 0 0 1 1 1 0 SPX domain Presenilin PF01080.17 EWC44302.1 - 0.15 10.8 14.8 0.22 10.2 14.8 1.1 1 0 0 1 1 1 0 Presenilin DUF4614 PF15391.6 EWC44302.1 - 0.33 10.9 33.0 0.72 9.8 33.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) SDA1 PF05285.12 EWC44302.1 - 0.61 9.5 10.7 0.9 8.9 10.7 1.1 1 0 0 1 1 1 0 SDA1 Macoilin PF09726.9 EWC44302.1 - 0.61 8.6 19.6 0.9 8.0 19.6 1.1 1 0 0 1 1 1 0 Macoilin family SLC12 PF03522.15 EWC44302.1 - 0.64 9.0 5.0 0.93 8.4 5.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 EWC44302.1 - 0.89 8.7 3.9 1.4 8.0 3.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Apt1 PF10351.9 EWC44302.1 - 0.93 8.3 23.8 1.4 7.7 23.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 EWC44302.1 - 1.6 7.9 33.0 0.16 11.1 23.3 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein PPP4R2 PF09184.11 EWC44302.1 - 3.1 7.3 20.1 5.2 6.6 20.1 1.2 1 0 0 1 1 1 0 PPP4R2 DUF572 PF04502.13 EWC44302.1 - 3.7 7.1 14.5 5.8 6.4 14.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) SNARE PF05739.19 EWC44303.1 - 0.16 12.0 0.7 0.26 11.3 0.7 1.3 1 0 0 1 1 1 0 SNARE domain SP_C-Propep PF08999.10 EWC44303.1 - 9.6 6.1 5.6 19 5.1 0.1 2.6 2 1 1 3 3 3 0 Surfactant protein C, N terminal propeptide MARVEL PF01284.23 EWC44305.1 - 0.00047 20.2 11.1 0.00047 20.2 11.1 1.8 1 1 1 2 2 2 1 Membrane-associating domain DUF4336 PF14234.6 EWC44306.1 - 1.8e-16 60.3 0.0 3.4e-11 42.9 0.0 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) AA_permease PF00324.21 EWC44307.1 - 5.9e-136 453.8 38.5 7.2e-136 453.6 38.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EWC44307.1 - 5e-41 140.9 41.7 6.3e-41 140.6 41.7 1.1 1 0 0 1 1 1 1 Amino acid permease Adeno_E3_CR2 PF02439.15 EWC44307.1 - 0.58 10.0 4.1 2 8.3 4.1 1.9 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Asp PF00026.23 EWC44308.1 - 1.1e-30 107.1 0.3 1.5e-30 106.7 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease SKG6 PF08693.10 EWC44308.1 - 0.0014 18.0 0.7 0.003 16.9 0.7 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain GRP PF07172.11 EWC44308.1 - 0.07 13.8 7.8 0.15 12.7 7.8 1.5 1 0 0 1 1 1 0 Glycine rich protein family FSH1 PF03959.13 EWC44310.1 - 9.4e-62 208.4 0.0 1.1e-61 208.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 EWC44310.1 - 0.05 13.5 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal HET PF06985.11 EWC44311.1 - 2.5e-05 24.7 0.1 8.7e-05 22.9 0.1 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Cu-oxidase_2 PF07731.14 EWC44312.1 - 3.5e-40 136.9 1.8 7.6e-34 116.4 0.0 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EWC44312.1 - 6.7e-38 129.4 3.1 1.6e-37 128.2 2.4 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EWC44312.1 - 4.6e-33 114.6 0.0 7.7e-32 110.6 0.0 2.3 2 0 0 2 2 2 1 Multicopper oxidase adh_short PF00106.25 EWC44314.1 - 2.9e-27 95.4 0.0 8.5e-20 71.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC44314.1 - 2e-19 70.1 0.0 1.5e-14 54.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC44314.1 - 1.1e-10 41.7 0.0 2.5e-10 40.6 0.0 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EWC44314.1 - 2.9e-08 33.5 0.0 5.1e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EWC44314.1 - 2.3e-06 27.3 0.1 1.9e-05 24.2 0.0 2.3 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EWC44314.1 - 0.0019 17.4 0.0 0.0031 16.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EWC44314.1 - 0.02 14.9 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EWC44314.1 - 0.13 12.5 0.0 0.38 11.0 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EWC44314.1 - 0.15 11.1 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain LSPR PF06049.12 EWC44314.1 - 0.44 10.6 4.1 0.2 11.6 0.5 2.4 2 0 0 2 2 2 0 Coagulation Factor V LSPD Repeat Tyrosinase PF00264.20 EWC44315.1 - 6.7e-44 150.8 0.4 8e-44 150.6 0.4 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Metallophos PF00149.28 EWC44317.1 - 5.9e-12 46.5 0.8 7.9e-12 46.1 0.8 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EWC44317.1 - 6.5e-06 26.4 0.5 0.00035 20.8 0.5 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MCD PF05292.11 EWC44317.1 - 0.12 11.9 0.0 0.34 10.5 0.0 1.7 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain Tautomerase_3 PF14832.6 EWC44318.1 - 2.1e-08 34.5 0.0 3e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme Tautomerase PF01361.21 EWC44318.1 - 0.16 11.9 0.0 0.55 10.2 0.0 1.9 1 1 0 1 1 1 0 Tautomerase enzyme Lysine_decarbox PF03641.14 EWC44319.1 - 3.1e-36 124.4 0.0 4.1e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EWC44319.1 - 1.2e-10 41.2 0.2 1.5e-10 40.9 0.2 1.2 1 0 0 1 1 1 1 SLOG cluster4 family S1-P1_nuclease PF02265.16 EWC44320.1 - 1.3e-63 215.1 0.0 1.5e-63 215.0 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease Inhibitor_I66 PF16850.5 EWC44321.1 - 3.1e-23 82.3 0.0 4e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I66 RicinB_lectin_2 PF14200.6 EWC44321.1 - 0.00027 21.6 0.0 0.002 18.8 0.0 2.0 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like DUF3509 PF12021.8 EWC44321.1 - 0.15 11.8 0.9 2 8.2 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3509) Romo1 PF10247.9 EWC44323.1 - 0.062 13.7 0.8 0.46 10.9 0.1 2.4 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 PhoR PF11808.8 EWC44323.1 - 3.2 8.2 7.2 0.22 11.9 0.7 2.1 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR Synaptobrevin PF00957.21 EWC44324.1 - 5.5e-32 109.4 0.0 7.4e-32 109.0 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EWC44324.1 - 1.1e-23 83.0 0.1 1.9e-23 82.3 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF5542 PF17696.1 EWC44324.1 - 0.017 15.2 0.5 0.029 14.5 0.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5542) Glyco_hydro_17 PF00332.18 EWC44326.1 - 3e-17 63.2 0.5 3.4e-16 59.7 0.5 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 CFEM PF05730.11 EWC44327.1 - 1.1e-05 25.5 4.1 1.1e-05 25.5 4.1 5.8 3 1 4 7 7 7 1 CFEM domain Inhibitor_I66 PF16850.5 EWC44328.1 - 1.2e-19 70.6 0.0 1.7e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I66 DUF2235 PF09994.9 EWC44330.1 - 1.9e-47 162.0 0.0 2.7e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SIS_2 PF13580.6 EWC44330.1 - 0.043 13.8 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 SIS domain V-ATPase_H_N PF03224.14 EWC44333.1 - 6.3e-68 229.4 0.0 1.3e-67 228.3 0.0 1.5 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EWC44333.1 - 1.6e-37 128.2 0.0 1.7e-36 124.9 0.0 2.4 2 0 0 2 2 2 1 V-ATPase subunit H Arm PF00514.23 EWC44333.1 - 0.014 15.4 1.1 0.14 12.2 0.0 3.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EWC44333.1 - 0.041 14.2 0.8 0.28 11.5 0.0 2.8 3 0 0 3 3 3 0 HEAT repeat Pkinase PF00069.25 EWC44334.1 - 6.2e-19 68.4 0.0 1.1e-18 67.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44334.1 - 7.9e-14 51.6 0.0 1.9e-11 43.8 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase KRTAP PF11759.8 EWC44334.1 - 1.5 9.4 8.1 0.23 12.0 3.3 2.0 2 0 0 2 2 2 0 Keratin-associated matrix Aminotran_4 PF01063.19 EWC44335.1 - 5.7e-33 114.7 0.0 7.3e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Fungal_trans PF04082.18 EWC44336.1 - 6.6e-23 81.1 0.0 3.5e-22 78.7 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EWC44336.1 - 4.4e-07 30.0 5.7 0.014 15.8 0.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC44336.1 - 4.9e-07 30.0 5.0 0.0036 18.0 0.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EWC44336.1 - 0.042 14.3 1.1 6.2 7.4 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EWC44336.1 - 0.97 9.8 6.1 1.8 8.9 1.7 2.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EWC44336.1 - 1.6 8.8 7.9 2.6 8.1 0.4 2.5 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_6 PF13912.6 EWC44336.1 - 2.4 8.3 8.3 0.15 12.1 1.0 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EWC44336.1 - 9.8 6.8 15.4 1.8 9.2 4.4 3.0 3 0 0 3 3 3 0 Zinc-finger double domain Mucin PF01456.17 EWC44337.1 - 0.26 11.2 11.6 0.46 10.5 11.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 EWC44337.1 - 0.28 11.1 2.4 0.4 10.7 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4604 PF15377.6 EWC44337.1 - 0.3 11.5 7.5 0.46 10.9 7.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Dicty_REP PF05086.12 EWC44337.1 - 0.34 8.8 5.4 0.4 8.6 5.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AJAP1_PANP_C PF15298.6 EWC44337.1 - 0.46 10.7 7.5 0.63 10.2 7.5 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus RR_TM4-6 PF06459.12 EWC44337.1 - 0.86 9.4 3.7 0.99 9.2 3.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 KIX_2 PF16987.5 EWC44338.1 - 6.6e-08 32.4 1.0 6.8e-07 29.2 0.5 2.6 2 1 0 2 2 2 1 KIX domain BTB PF00651.31 EWC44339.1 - 1.8e-09 37.8 0.1 2e-08 34.4 0.0 2.2 2 1 1 3 3 3 1 BTB/POZ domain Ank PF00023.30 EWC44340.1 - 3.7e-07 30.3 0.0 0.15 12.6 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat TPR_12 PF13424.6 EWC44340.1 - 7.9e-07 29.3 0.2 0.026 14.8 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Ank_2 PF12796.7 EWC44340.1 - 5.6e-06 26.8 0.0 0.00025 21.6 0.0 2.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EWC44340.1 - 1.3e-05 25.2 0.1 1.9 9.3 0.0 4.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EWC44340.1 - 4.9e-05 23.8 0.0 0.16 12.6 0.0 3.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) TPR_10 PF13374.6 EWC44340.1 - 0.0012 18.6 0.7 2.8 7.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Helo_like_N PF17111.5 EWC44340.1 - 0.0037 16.7 1.6 0.023 14.1 0.1 2.2 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins TPR_19 PF14559.6 EWC44340.1 - 0.0045 17.5 0.0 0.37 11.3 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Ank_5 PF13857.6 EWC44340.1 - 0.0073 16.6 0.4 0.095 13.0 0.0 2.8 3 0 0 3 3 2 1 Ankyrin repeats (many copies) TPR_2 PF07719.17 EWC44340.1 - 0.01 15.9 0.1 2.6 8.4 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EWC44340.1 - 0.018 15.1 0.0 15 5.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Rhabdo_NV PF02484.15 EWC44340.1 - 0.063 13.4 0.1 5 7.3 0.0 2.4 2 0 0 2 2 2 0 Rhabdovirus Non-virion protein ATP_bind_2 PF03668.15 EWC44341.1 - 3.4e-05 23.3 0.0 0.005 16.2 0.0 2.0 2 0 0 2 2 2 2 P-loop ATPase protein family DUF1043 PF06295.12 EWC44341.1 - 0.094 12.7 0.2 0.14 12.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) FAD_binding_4 PF01565.23 EWC44342.1 - 4.7e-25 88.0 1.8 8.3e-25 87.1 1.0 1.8 2 1 0 2 2 2 1 FAD binding domain BBE PF08031.12 EWC44342.1 - 0.0053 16.8 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Flavi_M PF01004.19 EWC44343.1 - 0.1 12.4 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 Flavivirus envelope glycoprotein M MFS_1 PF07690.16 EWC44346.1 - 8.2e-26 90.8 37.5 8.2e-26 90.8 37.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EWC44347.1 - 2.7e-25 89.1 42.3 2e-14 53.3 26.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OCC1 PF15506.6 EWC44347.1 - 0.059 13.5 0.4 0.14 12.3 0.4 1.6 1 0 0 1 1 1 0 OCC1 family Ribosomal_L6 PF00347.23 EWC44348.1 - 1.5e-26 92.9 10.7 4.1e-13 49.8 2.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 GatB_N PF02934.15 EWC44348.1 - 0.055 12.8 0.6 0.062 12.7 0.6 1.1 1 0 0 1 1 1 0 GatB/GatE catalytic domain ESSS PF10183.9 EWC44350.1 - 4.8e-16 58.9 0.1 4.4e-14 52.6 0.0 2.3 2 0 0 2 2 2 2 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) MOSC PF03473.17 EWC44351.1 - 2.7e-23 82.4 0.0 5e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EWC44351.1 - 3.7e-18 65.5 0.0 6.2e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Neur PF00064.18 EWC44351.1 - 0.015 14.1 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 Neuraminidase Lipase_GDSL_3 PF14606.6 EWC44352.1 - 0.0033 17.6 0.0 0.0042 17.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Peptidase_M49 PF03571.15 EWC44354.1 - 5.1e-238 790.9 0.0 6.4e-238 790.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 WSC PF01822.19 EWC44357.1 - 3.5e-56 187.4 87.2 1e-16 60.9 8.0 7.5 6 1 0 6 6 6 5 WSC domain CyRPA PF18638.1 EWC44357.1 - 0.04 13.1 0.0 0.07 12.3 0.0 1.3 1 0 0 1 1 1 0 Cysteine-Rich Protective Antigen 6 bladed domain SOG2 PF10428.9 EWC44358.1 - 0.03 13.6 12.8 0.04 13.1 12.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 EWC44358.1 - 0.11 12.4 5.6 0.14 12.0 5.6 1.1 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 EWC44358.1 - 0.33 9.6 5.0 0.42 9.2 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 EWC44358.1 - 9 6.2 6.8 13 5.7 6.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rad60-SLD PF11976.8 EWC44359.1 - 5.3e-21 74.2 0.1 6.3e-21 74.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EWC44359.1 - 2.1e-12 46.6 0.0 2.4e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family MTCP1 PF08991.10 EWC44360.1 - 8e-26 90.1 9.6 9.8e-26 89.8 9.6 1.1 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 EWC44360.1 - 0.0061 16.7 9.5 0.012 15.7 9.5 1.6 1 0 0 1 1 1 1 CHCH domain Nup84_Nup100 PF04121.13 EWC44361.1 - 2.4e-176 588.0 0.0 2.8e-176 587.8 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TPR_4 PF07721.14 EWC44361.1 - 0.037 14.7 0.3 11 7.0 0.3 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EWC44361.1 - 0.057 13.7 1.0 1.6 9.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EWC44361.1 - 0.084 13.1 0.0 0.38 11.1 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat V-ATPase_C PF03223.15 EWC44362.1 - 2.8e-116 389.0 0.0 3.2e-116 388.8 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C mRNA_cap_C PF03919.15 EWC44362.1 - 0.029 15.0 0.1 0.064 13.9 0.1 1.6 1 0 0 1 1 1 0 mRNA capping enzyme, C-terminal domain Mod_r PF07200.13 EWC44362.1 - 3.8 7.6 7.4 20 5.3 4.7 2.8 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein tRNA-synt_2b PF00587.25 EWC44363.1 - 1.1e-33 116.7 0.0 2.1e-33 115.8 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EWC44363.1 - 5.3e-10 39.3 0.7 9.9e-10 38.5 0.7 1.5 1 0 0 1 1 1 1 Anticodon binding domain GCV_T PF01571.21 EWC44364.1 - 3.5e-83 278.9 0.0 4.5e-83 278.6 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EWC44364.1 - 6.6e-21 74.0 0.1 1.3e-20 73.1 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 EWC44364.1 - 1.3e-05 25.4 0.1 0.0001 22.5 0.0 2.5 4 0 0 4 4 4 1 Sarcosine oxidase, gamma subunit family CBF PF03914.17 EWC44365.1 - 1.2e-55 188.2 0.5 1.2e-55 188.2 0.5 3.4 4 1 0 4 4 4 1 CBF/Mak21 family Cnd1 PF12717.7 EWC44365.1 - 0.1 12.6 1.5 0.28 11.2 0.2 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 F-box-like PF12937.7 EWC44366.1 - 5e-05 23.1 0.0 0.00013 21.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC44366.1 - 0.2 11.6 1.8 4.3 7.3 1.8 2.6 1 1 0 1 1 1 0 F-box domain Aldedh PF00171.22 EWC44367.1 - 2.9e-108 362.4 0.0 3.5e-108 362.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_S8 PF00082.22 EWC44368.1 - 2.9e-41 141.7 0.1 1.1e-40 139.7 0.1 1.8 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EWC44368.1 - 6e-14 52.7 0.0 1.6e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain PA PF02225.22 EWC44368.1 - 0.00063 19.7 0.6 0.00063 19.7 0.6 2.8 3 0 0 3 3 3 1 PA domain NPCBM_assoc PF10633.9 EWC44368.1 - 0.24 11.7 3.4 7.6 6.9 0.1 3.5 3 0 0 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase F-box-like PF12937.7 EWC44369.1 - 1.4e-11 44.1 0.2 1.9e-11 43.7 0.2 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC44369.1 - 0.00012 21.9 1.0 0.00087 19.1 1.0 2.2 1 1 0 1 1 1 1 F-box domain FAD_binding_4 PF01565.23 EWC44370.1 - 1.8e-20 73.1 3.1 1.8e-20 73.1 3.1 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EWC44370.1 - 0.0023 18.0 0.0 0.0055 16.8 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like DUF5363 PF17320.2 EWC44370.1 - 0.034 14.0 0.5 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5363) AA_permease PF00324.21 EWC44371.1 - 5.2e-142 473.8 37.6 6.4e-142 473.5 37.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EWC44371.1 - 1.8e-40 139.1 41.7 2.3e-40 138.8 41.7 1.0 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.16 EWC44372.1 - 6.6e-42 143.7 47.3 6.6e-42 143.7 47.3 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Acetyltransf_3 PF13302.7 EWC44373.1 - 4.9e-13 49.9 0.0 6e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EWC44373.1 - 1.9e-06 28.1 0.0 2.6e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EWC44373.1 - 0.019 15.4 0.0 0.027 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_hydro_61 PF03443.14 EWC44375.1 - 2.1e-50 171.5 0.0 2.9e-50 171.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 bZIP_1 PF00170.21 EWC44376.1 - 0.21 11.7 11.0 0.38 10.9 11.0 1.4 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 EWC44376.1 - 0.38 10.9 9.4 0.7 10.0 9.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Sod_Fe_C PF02777.18 EWC44377.1 - 7.9e-33 112.7 0.2 1.5e-32 111.8 0.1 1.5 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EWC44377.1 - 1.5e-24 86.3 9.9 1.5e-24 86.3 9.9 2.5 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Glyoxalase PF00903.25 EWC44380.1 - 0.00019 21.6 0.0 0.0018 18.4 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EWC44380.1 - 0.023 15.5 0.0 0.046 14.5 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase-like domain Asp PF00026.23 EWC44381.1 - 1.8e-48 165.6 0.3 2.1e-48 165.4 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EWC44381.1 - 1.6e-06 28.7 0.9 0.0013 19.3 0.3 3.1 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.6 EWC44381.1 - 0.00081 19.2 0.0 0.0061 16.3 0.0 2.4 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 EWC44381.1 - 0.015 15.5 0.1 0.28 11.4 0.1 2.2 1 1 0 1 1 1 0 Xylanase inhibitor N-terminal VPDSG-CTERM PF18205.1 EWC44381.1 - 0.018 14.8 1.0 0.034 14.0 1.0 1.4 1 0 0 1 1 1 0 VPDSG-CTERM motif gag-asp_proteas PF13975.6 EWC44381.1 - 0.03 14.9 0.4 0.2 12.2 0.2 2.4 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease NAD_binding_4 PF07993.12 EWC44382.1 - 0.034 13.3 0.0 0.26 10.4 0.0 2.0 2 0 0 2 2 2 0 Male sterility protein FAD_binding_3 PF01494.19 EWC44383.1 - 5.6e-22 78.5 0.2 8.7e-22 77.8 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EWC44383.1 - 2.6e-07 30.2 0.1 0.00033 20.0 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC44383.1 - 0.00016 21.4 11.7 0.063 12.9 0.0 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EWC44383.1 - 0.0002 20.2 4.0 0.19 10.4 2.5 2.1 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 EWC44383.1 - 0.00021 21.4 2.9 0.00063 19.9 2.5 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EWC44383.1 - 0.00025 21.6 0.2 0.0092 16.5 0.6 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EWC44383.1 - 0.0063 15.8 0.1 0.014 14.7 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 EWC44383.1 - 0.0066 15.3 1.7 0.44 9.3 0.2 2.7 3 1 0 3 3 3 2 Tryptophan halogenase FAD_binding_2 PF00890.24 EWC44383.1 - 0.0068 15.5 5.9 0.016 14.3 4.1 2.1 1 1 1 2 2 2 1 FAD binding domain Amino_oxidase PF01593.24 EWC44383.1 - 0.036 13.4 0.5 5.8 6.1 0.1 2.7 2 1 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EWC44383.1 - 0.053 12.6 2.4 0.31 10.1 2.1 2.3 2 1 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 EWC44383.1 - 0.1 11.7 0.1 0.16 11.0 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Glyco_hydro_64 PF16483.5 EWC44385.1 - 5.8e-55 187.1 0.0 3.1e-27 95.8 0.0 2.0 1 1 1 2 2 2 2 Beta-1,3-glucanase Benyvirus_14KDa PF07255.11 EWC44385.1 - 0.13 12.5 0.1 0.22 11.7 0.1 1.3 1 0 0 1 1 1 0 Benyvirus 14KDa protein Cellulase PF00150.18 EWC44386.1 - 6.1e-23 81.6 0.2 1.1e-22 80.9 0.2 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 EWC44386.1 - 2.7e-12 46.4 7.3 8.5e-12 44.8 7.3 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain Glyco_hydro_2_C PF02836.17 EWC44386.1 - 5.5e-07 29.0 0.1 1.8e-06 27.3 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 EWC44386.1 - 0.00027 20.4 0.1 0.0018 17.7 0.0 2.2 2 1 0 2 2 2 1 Beta-galactosidase Apt1 PF10351.9 EWC44386.1 - 0.17 10.7 3.1 0.21 10.4 3.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 EWC44386.1 - 0.89 8.7 16.7 1.2 8.2 16.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SDA1 PF05285.12 EWC44387.1 - 0.031 13.7 23.2 0.046 13.2 23.2 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EWC44387.1 - 0.28 9.3 26.3 0.42 8.8 26.3 1.2 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 EWC44387.1 - 0.29 11.2 18.0 0.51 10.4 18.0 1.5 1 0 0 1 1 1 0 YL1 nuclear protein Trypan_PARP PF05887.11 EWC44387.1 - 0.34 10.9 11.3 0.75 9.8 11.3 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Cnd2 PF05786.14 EWC44387.1 - 0.51 8.9 14.4 0.7 8.5 14.4 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 Vfa1 PF08432.10 EWC44387.1 - 0.77 10.1 2.7 1.5 9.2 2.7 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mpp10 PF04006.12 EWC44387.1 - 2.2 6.6 17.7 3.2 6.1 17.7 1.1 1 0 0 1 1 1 0 Mpp10 protein CDC45 PF02724.14 EWC44387.1 - 6.1 5.0 18.9 8.8 4.5 18.9 1.1 1 0 0 1 1 1 0 CDC45-like protein MFS_1 PF07690.16 EWC44389.1 - 5.8e-30 104.4 46.5 2.5e-27 95.8 16.8 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EWC44389.1 - 2.8e-13 49.2 6.2 4.4e-13 48.5 6.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EWC44389.1 - 8.1e-09 34.8 3.7 8.1e-09 34.8 3.7 2.1 3 0 0 3 3 3 1 Sugar (and other) transporter Spc110_C PF18520.1 EWC44391.1 - 0.068 12.8 3.1 0.15 11.7 0.0 2.2 1 1 1 2 2 2 0 Spindle pole body component 110 C-terminal domain DUF2235 PF09994.9 EWC44392.1 - 5.7e-77 258.9 0.0 7.1e-77 258.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Gaa1 PF04114.14 EWC44394.1 - 1.8 7.5 11.2 0.18 10.8 5.4 1.7 1 1 0 2 2 2 0 Gaa1-like, GPI transamidase component Popeye PF04831.13 EWC44394.1 - 7.9 6.6 8.7 1.6 8.9 4.6 1.9 2 0 0 2 2 2 0 Popeye protein conserved region DUF515 PF04415.12 EWC44395.1 - 2.4 6.4 5.1 3 6.1 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Dabb PF07876.12 EWC44397.1 - 1.5e-12 48.0 0.0 1.8e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain HCO3_cotransp PF00955.21 EWC44398.1 - 3.4e-78 263.7 6.0 1.1e-38 133.3 4.5 2.1 1 1 1 2 2 2 2 HCO3- transporter family PepSY_TM PF03929.16 EWC44398.1 - 1.3 8.6 8.4 2.2 7.9 0.3 3.3 3 0 0 3 3 3 0 PepSY-associated TM region Tyrosinase PF00264.20 EWC44400.1 - 2.6e-49 168.5 7.2 4.1e-49 167.9 7.2 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EWC44400.1 - 1.6e-28 99.9 0.0 2.8e-28 99.0 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Chlam_PMP PF02415.17 EWC44400.1 - 1.3 9.6 4.0 3.4 8.4 0.4 3.2 2 1 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat SNARE_assoc PF09335.11 EWC44401.1 - 9.9e-19 68.0 8.9 9.9e-19 68.0 8.9 2.5 3 0 0 3 3 3 1 SNARE associated Golgi protein FxsA PF04186.13 EWC44401.1 - 0.031 14.4 0.9 0.031 14.4 0.9 3.0 1 1 2 4 4 4 0 FxsA cytoplasmic membrane protein SieB PF14163.6 EWC44401.1 - 0.16 11.4 9.3 0.85 9.1 0.2 2.7 3 0 0 3 3 3 0 Super-infection exclusion protein B DUF3278 PF11683.8 EWC44401.1 - 0.22 11.6 1.5 0.73 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) DUF2681 PF10883.8 EWC44401.1 - 0.54 10.7 4.3 0.87 10.0 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Phage_holin_3_6 PF07332.11 EWC44401.1 - 1.1 9.3 21.9 3.4 7.7 0.1 3.5 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III PBP_N PF17093.5 EWC44401.1 - 7.7 6.8 9.6 13 6.1 4.5 2.9 2 1 0 2 2 2 0 Penicillin-binding protein N-terminus Glyco_hydro_3_C PF01915.22 EWC44403.1 - 1.5e-50 172.0 0.1 1.5e-50 172.0 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EWC44403.1 - 4.7e-43 147.8 0.0 9.2e-43 146.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EWC44403.1 - 4.6e-24 84.3 0.0 8.5e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CBM_1 PF00734.18 EWC44403.1 - 2e-11 43.6 6.6 6.2e-11 42.1 6.6 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain SOG2 PF10428.9 EWC44403.1 - 1.3 8.2 13.8 2.4 7.3 13.8 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein WSC PF01822.19 EWC44404.1 - 2.5e-14 53.2 11.1 2.4e-11 43.7 7.0 2.7 2 0 0 2 2 2 2 WSC domain PapD_N PF00345.20 EWC44404.1 - 0.23 11.4 0.3 0.41 10.5 0.3 1.3 1 0 0 1 1 1 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain PQQ_3 PF13570.6 EWC44404.1 - 0.25 11.9 0.0 0.25 11.9 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain Aldo_ket_red PF00248.21 EWC44405.1 - 1.2e-58 198.6 0.0 1.5e-58 198.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Metallophos PF00149.28 EWC44406.1 - 6.3e-13 49.7 0.0 1e-12 49.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pyridoxal_deC PF00282.19 EWC44407.1 - 5.7e-81 272.1 0.0 7.8e-81 271.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 EWC44407.1 - 0.12 11.7 0.1 0.2 10.9 0.1 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family adh_short PF00106.25 EWC44408.1 - 8.1e-44 149.4 0.2 1.1e-43 149.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC44408.1 - 9.7e-43 146.4 0.1 1.2e-42 146.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC44408.1 - 1.5e-12 47.8 0.3 2.4e-12 47.2 0.3 1.2 1 0 0 1 1 1 1 KR domain LT-IIB PF06453.11 EWC44408.1 - 0.1 12.5 0.0 0.72 9.8 0.0 2.2 2 0 0 2 2 2 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) His_Phos_2 PF00328.22 EWC44409.1 - 2.6e-61 208.1 0.0 3.1e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) COesterase PF00135.28 EWC44411.1 - 4.2e-63 214.0 0.0 5.5e-63 213.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EWC44411.1 - 7.2e-05 22.7 0.2 0.001 19.0 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EWC44411.1 - 0.00047 19.7 0.2 0.00076 19.0 0.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 EWC44411.1 - 0.0031 16.4 0.0 0.0079 15.1 0.0 1.6 1 1 0 1 1 1 1 Steryl acetyl hydrolase CAP PF00188.26 EWC44412.1 - 3.2e-18 66.8 7.8 6.1e-18 65.9 7.8 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family DUF829 PF05705.14 EWC44413.1 - 1.3e-33 116.9 0.0 1.6e-33 116.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) NMO PF03060.15 EWC44413.1 - 0.24 10.7 0.1 0.36 10.2 0.1 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Glyco_hydro_17 PF00332.18 EWC44414.1 - 1.6e-20 73.9 0.6 1.9e-20 73.7 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 LRR_4 PF12799.7 EWC44415.1 - 3.7e-11 43.1 3.3 0.0011 19.4 0.0 4.6 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EWC44415.1 - 4.1e-10 39.3 1.7 0.0015 18.2 0.0 3.5 2 1 2 4 4 4 4 Leucine rich repeat LRR_9 PF14580.6 EWC44415.1 - 0.011 15.2 0.0 0.2 11.2 0.0 2.3 1 1 2 3 3 3 0 Leucine-rich repeat LRR_1 PF00560.33 EWC44415.1 - 0.031 14.8 2.7 2.9 8.8 0.1 3.9 3 2 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 EWC44415.1 - 0.051 13.6 0.6 16 5.8 0.1 3.8 4 0 0 4 4 4 0 Leucine Rich repeat DUF3246 PF11596.8 EWC44415.1 - 0.14 11.6 2.2 0.2 11.1 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) NOA36 PF06524.12 EWC44415.1 - 5.3 6.3 7.2 7.3 5.8 7.2 1.1 1 0 0 1 1 1 0 NOA36 protein Glyco_hydro_79C PF16862.5 EWC44416.1 - 9.8e-14 52.1 0.5 4.3e-13 50.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain FKBP_C PF00254.28 EWC44417.1 - 1.8e-31 108.3 0.0 2e-31 108.1 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase His_Phos_1 PF00300.22 EWC44418.1 - 5.3e-19 68.7 0.0 8.2e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ZZ PF00569.17 EWC44419.1 - 0.0036 17.1 6.5 0.0063 16.3 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type HypA PF01155.19 EWC44419.1 - 0.21 11.6 1.3 0.37 10.8 1.3 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Sgf11 PF08209.11 EWC44419.1 - 0.5 10.0 2.8 0.3 10.7 0.2 1.9 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) AAR2 PF05282.11 EWC44420.1 - 1.4e-75 255.0 0.0 1.6e-75 254.7 0.0 1.1 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S9 PF00380.19 EWC44421.1 - 3.2e-32 111.6 0.1 3.6e-32 111.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Med27 PF11571.8 EWC44422.1 - 3.5e-13 49.7 0.1 1.3e-12 47.9 0.1 2.0 1 1 0 1 1 1 1 Mediator complex subunit 27 Orn_Arg_deC_N PF02784.16 EWC44423.1 - 2.8e-63 213.6 0.0 3.5e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EWC44423.1 - 2.7e-15 56.4 0.0 4.8e-15 55.6 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Glyco_hydro_36 PF17167.4 EWC44423.1 - 0.19 10.4 0.0 0.26 9.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain Ribosomal_S11 PF00411.19 EWC44424.1 - 1.3e-45 154.3 1.3 1.6e-45 154.0 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EWC44424.1 - 0.086 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) AA_permease_2 PF13520.6 EWC44425.1 - 3.8e-63 213.8 47.1 4.9e-63 213.4 47.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC44425.1 - 5.2e-18 64.9 41.1 7.4e-18 64.4 41.1 1.2 1 0 0 1 1 1 1 Amino acid permease DUF5411 PF17424.2 EWC44426.1 - 1.3 9.0 3.4 3.2 7.7 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5411) TPR_12 PF13424.6 EWC44427.1 - 9.6e-38 128.3 28.1 3.2e-11 43.3 1.7 8.0 3 1 6 9 9 9 6 Tetratricopeptide repeat TPR_10 PF13374.6 EWC44427.1 - 9.6e-33 111.1 11.8 5.3e-07 29.3 0.0 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 EWC44427.1 - 1.3e-11 43.6 8.5 0.0058 16.6 1.5 6.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EWC44427.1 - 1.4e-10 40.5 5.4 0.0023 18.0 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC44427.1 - 7.1e-10 38.3 13.2 0.0016 18.2 1.3 7.1 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EWC44427.1 - 5.3e-09 36.5 5.5 0.00055 20.4 0.3 5.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EWC44427.1 - 2.2e-07 30.4 6.6 0.058 13.5 0.8 5.3 5 1 0 5 5 4 2 Tetratricopeptide repeat NB-ARC PF00931.22 EWC44427.1 - 3.6e-07 29.6 0.0 4.4e-06 26.1 0.0 2.3 1 1 0 1 1 1 1 NB-ARC domain TPR_4 PF07721.14 EWC44427.1 - 1.9e-06 28.0 6.0 0.47 11.2 0.1 6.3 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EWC44427.1 - 1.9e-06 28.2 16.1 0.31 12.0 0.6 7.0 6 1 1 7 7 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EWC44427.1 - 6.9e-06 26.4 10.8 0.51 11.1 1.2 6.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EWC44427.1 - 1e-05 26.0 13.7 0.011 16.3 3.4 6.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EWC44427.1 - 0.00016 21.2 4.5 0.31 10.4 1.2 3.1 2 1 1 3 3 3 2 MalT-like TPR region NACHT PF05729.12 EWC44427.1 - 0.00037 20.5 0.1 0.0025 17.8 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EWC44427.1 - 0.00075 19.8 0.0 0.0043 17.3 0.0 2.3 1 0 0 1 1 1 1 AAA domain Abhydrolase_6 PF12697.7 EWC44427.1 - 0.0087 16.7 0.4 0.033 14.8 0.2 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family SPO22 PF08631.10 EWC44427.1 - 0.0098 15.4 0.5 1.3 8.4 0.1 2.6 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like TPR_9 PF13371.6 EWC44427.1 - 0.014 15.5 6.5 5.4 7.2 0.0 5.3 3 2 3 6 6 6 0 Tetratricopeptide repeat IstB_IS21 PF01695.17 EWC44427.1 - 0.017 14.8 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PGAP1 PF07819.13 EWC44427.1 - 0.023 14.4 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein TPR_3 PF07720.12 EWC44427.1 - 0.041 13.9 8.8 4.2 7.5 2.9 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat AAA_25 PF13481.6 EWC44427.1 - 0.047 13.3 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain ANAPC3 PF12895.7 EWC44427.1 - 0.11 12.7 1.9 1.3 9.3 0.2 3.5 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EWC44427.1 - 0.54 10.0 8.8 15 5.4 0.9 4.7 5 0 0 5 5 5 0 TPR repeat DUF3619 PF12279.8 EWC44427.1 - 0.6 10.4 3.8 0.81 10.0 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3619) TPR_17 PF13431.6 EWC44427.1 - 0.92 10.0 2.8 35 5.1 0.3 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat MIT PF04212.18 EWC44427.1 - 3.5 7.8 7.2 2.2 8.4 1.4 3.3 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Ank_2 PF12796.7 EWC44428.1 - 2.4e-27 95.3 18.3 3.3e-07 30.8 0.1 10.5 6 2 2 10 10 10 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC44428.1 - 6.1e-13 49.0 3.2 0.093 13.3 0.0 9.4 12 1 0 12 12 12 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC44428.1 - 2.7e-12 45.7 6.4 11 6.9 0.0 12.5 16 0 0 16 16 16 2 Ankyrin repeat Ank_5 PF13857.6 EWC44428.1 - 5.4e-10 39.3 0.8 0.24 11.8 0.0 7.5 7 2 2 9 9 9 3 Ankyrin repeats (many copies) Ank PF00023.30 EWC44428.1 - 4.4e-08 33.2 10.1 6 7.5 0.0 11.0 11 0 0 11 11 11 1 Ankyrin repeat Amidase PF01425.21 EWC44431.1 - 5.5e-92 309.1 0.0 8e-92 308.5 0.0 1.2 1 0 0 1 1 1 1 Amidase FPN1 PF06963.12 EWC44432.1 - 3.4e-20 72.0 0.1 3.3e-17 62.2 0.0 2.0 2 0 0 2 2 2 2 Ferroportin1 (FPN1) Ferric_reduct PF01794.19 EWC44433.1 - 1.3e-23 83.5 6.7 1.3e-23 83.5 6.7 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EWC44433.1 - 1.3e-18 67.6 0.0 7.9e-12 45.6 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EWC44433.1 - 5.5e-14 52.2 0.0 3.3e-10 40.0 0.1 2.5 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 EWC44433.1 - 0.062 14.0 0.0 0.17 12.5 0.0 1.8 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Vps39_2 PF10367.9 EWC44434.1 - 5.1e-07 30.1 0.0 1.2e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EWC44434.1 - 0.0054 16.6 0.0 0.064 13.1 0.0 2.7 4 0 0 4 4 4 1 Region in Clathrin and VPS Vps39_1 PF10366.9 EWC44434.1 - 0.069 13.4 0.0 18 5.7 0.0 2.8 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 CASP_C PF08172.12 EWC44435.1 - 5.4e-82 274.9 0.1 5.4e-82 274.9 0.1 5.3 3 1 2 5 5 4 1 CASP C terminal APG6_N PF17675.1 EWC44435.1 - 0.00061 20.3 63.5 0.0045 17.5 3.5 5.9 4 1 2 6 6 6 3 Apg6 coiled-coil region bZIP_1 PF00170.21 EWC44435.1 - 0.0065 16.5 4.3 0.0065 16.5 4.3 6.9 6 1 1 7 7 7 2 bZIP transcription factor ZapB PF06005.12 EWC44435.1 - 0.019 15.4 0.2 0.019 15.4 0.2 6.7 3 2 2 5 5 4 0 Cell division protein ZapB HAP1_N PF04849.13 EWC44435.1 - 0.042 13.0 0.1 0.042 13.0 0.1 4.4 4 1 0 4 4 4 0 HAP1 N-terminal conserved region FlaC_arch PF05377.11 EWC44435.1 - 0.047 14.1 34.3 2.2 8.8 0.4 6.7 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 EWC44435.1 - 0.065 13.7 0.6 0.065 13.7 0.6 6.2 4 2 2 7 7 7 0 Centromere protein H (CENP-H) YabA PF06156.13 EWC44435.1 - 0.24 12.1 34.3 3.4 8.3 4.1 6.0 4 1 1 5 5 5 0 Initiation control protein YabA JIP_LZII PF16471.5 EWC44435.1 - 0.5 10.6 49.2 0.047 13.9 3.1 7.1 5 2 1 6 6 6 0 JNK-interacting protein leucine zipper II Baculo_PEP_C PF04513.12 EWC44435.1 - 0.69 10.0 21.5 9.4 6.3 1.1 4.6 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus bZIP_2 PF07716.15 EWC44435.1 - 3.6 7.7 58.4 0.089 12.9 2.5 8.1 7 2 2 10 10 10 0 Basic region leucine zipper Wtap PF17098.5 EWC44435.1 - 7.1 6.5 36.0 0.28 11.1 0.9 5.0 2 1 0 3 3 2 0 WTAP/Mum2p family DUF948 PF06103.11 EWC44435.1 - 7.8 6.8 19.8 3 8.1 1.1 5.2 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EWC44435.1 - 9.3 6.4 33.0 2.6 8.2 0.2 5.2 5 1 1 6 6 6 0 Fibrinogen alpha/beta chain family GH131_N PF18271.1 EWC44436.1 - 2e-93 312.8 0.0 2.3e-93 312.6 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Polysacc_lyase PF14099.6 EWC44436.1 - 0.055 13.3 0.0 0.071 13.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide lyase Ribosomal_L22 PF00237.19 EWC44437.1 - 6.9e-44 148.3 0.3 1.1e-43 147.6 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Fibrillarin PF01269.17 EWC44438.1 - 7.6e-105 349.0 0.0 8.9e-105 348.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EWC44438.1 - 9.3e-06 25.5 0.0 1.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 EWC44438.1 - 0.012 15.3 0.0 0.033 13.8 0.0 1.7 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EWC44438.1 - 0.053 13.6 0.0 0.07 13.2 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 EWC44438.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fasciclin PF02469.22 EWC44439.1 - 2e-28 99.2 0.0 5.1e-14 52.6 0.0 2.5 2 1 0 2 2 2 2 Fasciclin domain PDH PF02153.17 EWC44440.1 - 4.2e-16 58.7 0.0 6e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 EWC44440.1 - 3.2e-07 30.8 0.1 8.4e-07 29.5 0.0 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EWC44440.1 - 9.5e-06 25.9 0.0 1.6e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EWC44440.1 - 1.9e-05 24.1 0.0 3.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EWC44440.1 - 2.3e-05 24.1 0.0 4.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EWC44440.1 - 0.0034 17.6 0.0 0.0069 16.6 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.12 EWC44440.1 - 0.0065 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain PocR PF10114.9 EWC44440.1 - 0.011 15.6 0.0 0.22 11.3 0.0 2.2 2 0 0 2 2 2 0 Sensory domain found in PocR 3HCDH_N PF02737.18 EWC44440.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EWC44440.1 - 0.023 14.8 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 EWC44440.1 - 0.072 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain EccE PF11203.8 EWC44440.1 - 0.084 13.2 0.3 6.1 7.2 0.0 2.4 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE XdhC_C PF13478.6 EWC44440.1 - 0.14 12.7 0.0 0.35 11.4 0.0 1.6 1 1 0 1 1 1 0 XdhC Rossmann domain Peptidase_C12 PF01088.21 EWC44443.1 - 1.7e-68 230.5 0.0 2.7e-68 229.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EWC44443.1 - 9.6e-14 51.0 1.7 2.2e-13 49.8 1.7 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Cutinase PF01083.22 EWC44444.1 - 1.2e-54 184.9 6.8 2.1e-54 184.2 6.8 1.4 1 0 0 1 1 1 1 Cutinase CBM_1 PF00734.18 EWC44444.1 - 4e-10 39.5 18.0 4e-10 39.5 18.0 5.3 4 2 0 4 4 4 1 Fungal cellulose binding domain PE-PPE PF08237.11 EWC44444.1 - 0.0012 18.4 0.2 0.0012 18.4 0.2 2.1 2 0 0 2 2 2 1 PE-PPE domain Mucin PF01456.17 EWC44444.1 - 0.003 17.6 35.1 0.003 17.6 35.1 2.0 2 1 0 2 2 2 1 Mucin-like glycoprotein VirJ PF06057.11 EWC44444.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Sporozoite_P67 PF05642.11 EWC44444.1 - 0.78 7.8 10.9 1.1 7.3 10.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FSA_C PF10479.9 EWC44444.1 - 3.8 5.5 15.9 6.4 4.8 15.9 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Dicty_REP PF05086.12 EWC44444.1 - 9.5 4.1 12.4 14 3.5 12.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Sulfotransfer_3 PF13469.6 EWC44445.1 - 0.17 12.2 0.0 7 7.0 0.0 2.3 2 0 0 2 2 2 0 Sulfotransferase family ATG27 PF09451.10 EWC44446.1 - 6.4e-74 249.1 0.0 7.5e-74 248.9 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 Cation_efflux PF01545.21 EWC44447.1 - 1.9e-13 50.6 10.8 2.4e-13 50.3 10.8 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EWC44447.1 - 1.3e-12 47.7 0.3 1.3e-12 47.7 0.3 1.6 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter Prefoldin_2 PF01920.20 EWC44448.1 - 4.4e-21 74.8 0.5 5.1e-21 74.6 0.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit CCDC24 PF15669.5 EWC44448.1 - 0.028 14.3 2.3 0.028 14.3 2.3 1.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family DUF5082 PF16888.5 EWC44448.1 - 0.059 13.7 0.3 0.083 13.2 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF465 PF04325.13 EWC44448.1 - 0.094 12.8 1.3 0.094 12.8 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF465) Nucleoporin_FG PF13634.6 EWC44449.1 - 4.8e-06 27.3 1.4 7.6e-06 26.7 1.4 1.2 1 0 0 1 1 1 1 Nucleoporin FG repeat region Peptidase_G2 PF11962.8 EWC44450.1 - 0.14 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase_G2, IMC autoproteolytic cleavage domain Neisseria_TspB PF05616.13 EWC44450.1 - 1.1 7.6 8.0 1.7 7.1 8.0 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DDRGK PF09756.9 EWC44452.1 - 9.6e-05 22.0 10.3 0.65 9.6 0.0 2.2 2 0 0 2 2 2 2 DDRGK domain DUF4337 PF14235.6 EWC44452.1 - 1.4 9.0 4.1 2.5 8.2 4.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Nucleoporin_FG PF13634.6 EWC44453.1 - 5.6e-06 27.1 111.1 0.00011 23.0 17.8 7.2 3 1 5 8 8 8 3 Nucleoporin FG repeat region Methyltransf_23 PF13489.6 EWC44454.1 - 5e-13 49.2 0.2 2e-12 47.2 0.2 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44454.1 - 4.7e-09 36.8 0.0 1.2e-08 35.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC44454.1 - 5.9e-07 30.2 0.0 1.3e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC44454.1 - 1.1e-06 29.2 0.0 2.2e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44454.1 - 1.9e-06 27.8 0.0 3.1e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EWC44454.1 - 0.071 12.6 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Zip PF02535.22 EWC44454.1 - 0.16 11.2 7.5 0.21 10.8 7.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NicO PF03824.16 EWC44454.1 - 3 7.1 10.8 4 6.7 10.8 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein Acetyltransf_1 PF00583.25 EWC44455.1 - 5.5e-07 29.8 0.0 8.4e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC44455.1 - 2.9e-05 24.0 0.0 0.0016 18.4 0.0 2.4 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC44455.1 - 0.00078 19.8 0.0 0.0013 19.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 EWC44455.1 - 0.016 15.9 0.0 0.96 10.2 0.0 3.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EWC44455.1 - 0.041 14.0 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DnaJ PF00226.31 EWC44457.1 - 4.2e-16 58.8 0.2 1e-15 57.6 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EWC44457.1 - 1.4e-09 37.5 0.0 7.6e-09 35.1 0.0 1.9 1 1 0 1 1 1 1 Sec63 Brl domain NOA36 PF06524.12 EWC44457.1 - 2.3 7.5 8.3 3.5 6.9 8.3 1.3 1 0 0 1 1 1 0 NOA36 protein Thaumatin PF00314.17 EWC44458.1 - 1.6e-50 171.7 0.4 6.2e-49 166.5 0.4 2.1 1 1 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 EWC44458.1 - 0.033 13.5 0.3 6 6.0 0.0 2.2 2 0 0 2 2 2 0 Beta-1,3-glucanase Methyltransf_PK PF05891.12 EWC44461.1 - 3.3e-75 252.4 0.0 9.5e-75 250.9 0.0 1.6 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EWC44461.1 - 0.00059 20.5 0.0 0.0011 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC44461.1 - 0.0071 16.2 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC44461.1 - 0.02 15.5 0.0 0.044 14.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 EWC44461.1 - 0.2 10.9 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain ADH_N PF08240.12 EWC44463.1 - 1.2e-26 92.7 0.2 2.2e-26 91.9 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC44463.1 - 1.8e-12 47.3 0.2 5.8e-10 39.3 0.2 2.4 1 1 1 2 2 2 2 Zinc-binding dehydrogenase TPT PF03151.16 EWC44464.1 - 1.3 8.3 19.8 5.5 6.2 19.8 1.8 1 1 0 1 1 1 0 Triose-phosphate Transporter family Inositol_P PF00459.25 EWC44465.1 - 6.2e-50 170.2 0.9 4.8e-49 167.3 1.0 1.9 1 1 0 1 1 1 1 Inositol monophosphatase family Grg1 PF11034.8 EWC44466.1 - 3.2e-22 78.5 4.3 3.8e-22 78.3 4.3 1.1 1 0 0 1 1 1 1 Glucose-repressible protein Grg1 DUF802 PF05650.11 EWC44466.1 - 0.013 15.9 0.0 0.095 13.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF802) Pectate_lyase PF03211.13 EWC44467.1 - 3.2e-85 284.8 6.4 4.5e-85 284.3 6.4 1.2 1 0 0 1 1 1 1 Pectate lyase CBM_1 PF00734.18 EWC44467.1 - 9.1e-12 44.7 13.2 9.1e-12 44.7 13.2 4.0 4 0 0 4 4 4 1 Fungal cellulose binding domain Cep57_MT_bd PF06657.13 EWC44470.1 - 3.7e-28 97.8 1.0 3.7e-28 97.8 1.0 4.5 5 0 0 5 5 5 1 Centrosome microtubule-binding domain of Cep57 Filament PF00038.21 EWC44470.1 - 0.0012 18.5 13.3 0.0012 18.5 13.3 4.5 5 0 0 5 5 5 2 Intermediate filament protein Prominin PF05478.11 EWC44470.1 - 5.9 4.7 5.9 14 3.4 5.9 1.7 1 0 0 1 1 1 0 Prominin AAA_16 PF13191.6 EWC44471.1 - 6.9e-33 114.4 0.9 1.8e-31 109.8 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain HATPase_c PF02518.26 EWC44471.1 - 1.2e-30 106.3 0.4 3e-30 105.0 0.4 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EWC44471.1 - 9.7e-26 90.1 0.6 5e-23 81.4 0.1 2.9 3 0 0 3 3 2 1 Response regulator receiver domain HisKA PF00512.25 EWC44471.1 - 5.2e-14 52.0 0.0 2.5e-13 49.9 0.0 2.3 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 EWC44471.1 - 1.5e-12 48.3 0.0 7.2e-12 46.1 0.0 2.3 2 0 0 2 2 2 1 GAF domain Pkinase PF00069.25 EWC44471.1 - 3.9e-10 39.5 0.0 7.1e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SPO22 PF08631.10 EWC44471.1 - 3.7e-08 33.2 0.6 3.7e-08 33.2 0.6 1.7 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like GAF_2 PF13185.6 EWC44471.1 - 9.4e-07 29.2 0.0 7.2e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 GAF domain Pkinase_Tyr PF07714.17 EWC44471.1 - 2.6e-05 23.7 0.0 7.2e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase GAF_3 PF13492.6 EWC44471.1 - 9.6e-05 22.7 0.0 0.00028 21.2 0.0 1.8 1 0 0 1 1 1 1 GAF domain AAA_22 PF13401.6 EWC44471.1 - 0.0042 17.4 0.0 0.017 15.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EWC44471.1 - 0.028 14.3 0.1 0.069 13.1 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 EWC44471.1 - 0.091 12.0 0.0 0.26 10.5 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin DUF3369 PF11849.8 EWC44471.1 - 0.12 12.5 0.1 0.49 10.6 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3369) Rad17 PF03215.15 EWC44471.1 - 0.14 12.0 0.0 2.9 7.8 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain ANAPC3 PF12895.7 EWC44471.1 - 2.7 8.3 5.6 1 9.7 0.0 3.1 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Cyclin PF08613.11 EWC44472.1 - 3e-34 118.7 1.0 2.6e-33 115.7 1.0 2.0 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EWC44472.1 - 0.00069 19.4 0.1 0.0015 18.3 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain HTH_3 PF01381.22 EWC44472.1 - 0.15 12.2 0.0 0.41 10.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix KRE9 PF05390.11 EWC44473.1 - 1.7e-22 80.1 2.5 1.7e-22 80.1 2.5 1.9 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 EWC44473.1 - 2.9e-15 56.8 0.3 6.5e-15 55.7 0.0 1.7 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Peptidase_M24 PF00557.24 EWC44474.1 - 7.8e-54 182.5 0.0 1e-53 182.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EWC44474.1 - 3.7e-22 78.4 0.0 7.7e-22 77.3 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain HTH_Bact PF18768.1 EWC44475.1 - 0.057 13.0 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix bacterial domain CBM_1 PF00734.18 EWC44477.1 - 2.3e-13 49.8 13.3 2.3e-13 49.8 13.3 2.0 2 0 0 2 2 2 1 Fungal cellulose binding domain Lipase_GDSL_2 PF13472.6 EWC44477.1 - 9.5e-09 35.9 0.3 1.7e-08 35.1 0.3 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Apt1 PF10351.9 EWC44477.1 - 2.3 6.9 8.4 3.2 6.5 8.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain QWRF PF04484.12 EWC44477.1 - 6.3 6.5 10.6 11 5.6 10.6 1.3 1 0 0 1 1 1 0 QWRF family Med22 PF06179.12 EWC44479.1 - 5.5e-17 61.9 1.2 6.9e-17 61.6 1.2 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Y_phosphatase2 PF03162.13 EWC44479.1 - 0.12 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Pinin_SDK_memA PF04696.13 EWC44480.1 - 9.5e-22 77.4 13.6 9.5e-22 77.4 13.6 2.1 2 1 0 2 2 2 1 pinin/SDK/memA/ protein conserved region tRNA-synt_2 PF00152.20 EWC44481.1 - 1.4e-87 293.7 0.0 1.8e-87 293.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EWC44481.1 - 1.8e-11 43.9 0.0 3.7e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Cwf_Cwc_15 PF04889.12 EWC44482.1 - 4.5e-87 291.9 24.6 5e-87 291.7 24.6 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Roughex PF06020.11 EWC44482.1 - 0.17 10.9 14.6 0.22 10.6 14.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein BUD22 PF09073.10 EWC44482.1 - 0.83 8.9 25.5 1.1 8.5 25.5 1.3 1 0 0 1 1 1 0 BUD22 DUF4519 PF15012.6 EWC44482.1 - 2.6 8.3 4.9 7.3 6.8 4.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) PHF5 PF03660.14 EWC44483.1 - 3.8e-53 178.1 9.7 4.2e-53 177.9 9.7 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EWC44483.1 - 0.23 9.3 5.7 0.24 9.2 5.7 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EWC44483.1 - 0.9 9.6 14.5 2.1 8.5 1.2 3.0 1 1 1 2 2 2 0 Double zinc ribbon RNase_PH PF01138.21 EWC44484.1 - 8e-21 74.9 0.0 1.6e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EWC44484.1 - 4e-14 52.4 0.0 7.5e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Abhydrolase_3 PF07859.13 EWC44485.1 - 3.4e-37 128.4 0.0 5.9e-37 127.6 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EWC44485.1 - 4e-05 22.7 0.0 0.0001 21.3 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family PSI_integrin PF17205.3 EWC44485.1 - 0.029 14.1 0.0 0.067 12.9 0.0 1.6 1 0 0 1 1 1 0 Integrin plexin domain Chlorophyllase PF07224.11 EWC44485.1 - 0.069 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase RRM_1 PF00076.22 EWC44489.1 - 1.2e-37 127.6 0.1 3.2e-12 46.1 0.1 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC44489.1 - 2.3e-16 59.4 0.0 0.00015 21.6 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM_7 PF16367.5 EWC44489.1 - 8.9e-06 25.7 0.0 0.0056 16.8 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif RRM PF10378.9 EWC44489.1 - 7.1e-05 22.5 2.0 7.1e-05 22.5 2.0 3.1 3 1 0 3 3 3 1 Putative RRM domain DUF4523 PF15023.6 EWC44489.1 - 0.00011 22.0 0.0 0.13 12.1 0.0 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF4523) RRM_3 PF08777.11 EWC44489.1 - 0.002 18.1 0.0 0.23 11.5 0.1 2.8 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 EWC44489.1 - 0.11 12.6 0.0 21 5.2 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 EWC44489.1 - 0.14 12.2 0.2 0.85 9.7 0.0 2.3 3 0 0 3 3 3 0 RNA binding domain Spo7_2_N PF15407.6 EWC44489.1 - 0.17 11.6 0.0 5.7 6.6 0.0 2.7 3 0 0 3 3 3 0 Sporulation protein family 7 EF-hand_like PF09279.11 EWC44489.1 - 0.2 12.1 0.2 0.39 11.2 0.2 1.4 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like CTK3 PF12243.8 EWC44490.1 - 1e-37 128.9 0.8 1.5e-37 128.3 0.8 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EWC44490.1 - 2.7e-15 56.3 5.3 2.7e-15 56.3 5.3 2.3 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus Acetyltransf_2 PF00797.17 EWC44491.1 - 4.9e-36 124.7 0.0 8.4e-36 124.0 0.0 1.4 1 1 0 1 1 1 1 N-acetyltransferase Abhydrolase_1 PF00561.20 EWC44492.1 - 3.7e-23 82.5 0.0 9.1e-22 77.9 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EWC44492.1 - 1.7e-15 58.2 3.9 2.8e-15 57.5 3.9 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC44492.1 - 1.2e-08 34.6 0.0 1.9e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 EWC44492.1 - 0.033 13.2 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) NACHT PF05729.12 EWC44493.1 - 7e-22 78.1 0.1 1.3e-21 77.3 0.1 1.4 1 0 0 1 1 1 1 NACHT domain WD40 PF00400.32 EWC44493.1 - 1.3e-16 60.7 25.4 1.5e-05 25.7 0.4 9.6 10 0 0 10 10 10 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EWC44493.1 - 3.8e-07 29.4 8.5 0.3 10.0 0.8 5.8 3 3 1 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EWC44493.1 - 1.6e-06 28.3 3.0 3 8.2 0.1 5.8 4 2 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC44493.1 - 0.0028 16.4 2.6 2.2 6.8 0.0 3.8 3 1 0 4 4 4 3 Nucleoporin Nup120/160 Gmad1 PF10647.9 EWC44493.1 - 0.043 13.6 0.1 4.3 7.0 0.0 3.6 3 2 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 EWC44493.1 - 0.31 11.0 1.6 1.1e+02 2.9 0.0 4.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat PNP_UDP_1 PF01048.20 EWC44494.1 - 2.2e-18 66.4 0.0 4.9e-18 65.2 0.0 1.5 1 1 0 1 1 1 1 Phosphorylase superfamily Sacchrp_dh_NADP PF03435.18 EWC44495.1 - 1.6e-12 47.8 0.0 2.5e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Phage_TAC_6 PF09550.10 EWC44495.1 - 0.068 13.6 0.8 0.2 12.1 0.8 1.8 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC PRCC PF10253.9 EWC44496.1 - 1.7e-37 130.3 0.2 1.7e-37 130.3 0.2 2.6 2 1 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting P5CR_dimer PF14748.6 EWC44497.1 - 1.7e-35 121.4 2.0 1.7e-35 121.4 2.0 1.7 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EWC44497.1 - 2.4e-11 44.1 1.0 1.1e-06 29.1 0.0 2.5 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent DHFR_1 PF00186.19 EWC44498.1 - 1.6e-15 57.1 0.0 1.3e-14 54.2 0.0 2.0 1 1 0 1 1 1 1 Dihydrofolate reductase RNA_POL_M_15KD PF02150.16 EWC44500.1 - 1.6e-12 47.0 3.5 1.6e-12 47.0 3.5 2.1 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EWC44500.1 - 2.6e-05 24.0 0.4 2.6e-05 24.0 0.4 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) GFA PF04828.14 EWC44500.1 - 0.038 14.3 5.3 0.87 10.0 0.1 2.4 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme HAUS5 PF14817.6 EWC44500.1 - 0.062 12.1 0.1 0.071 11.9 0.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 SR-25 PF10500.9 EWC44500.1 - 0.12 11.9 4.5 0.039 13.6 1.6 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DZR PF12773.7 EWC44500.1 - 0.18 11.9 3.2 3.2 7.8 1.5 2.3 2 0 0 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 EWC44500.1 - 0.61 10.1 6.2 5.7 7.0 0.2 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Nudix_N_2 PF14803.6 EWC44500.1 - 2.6 8.0 5.7 0.53 10.3 1.2 2.1 2 0 0 2 2 2 0 Nudix N-terminal Ribosomal_L12 PF00542.19 EWC44501.1 - 2.2e-22 79.2 6.8 2.2e-22 79.2 6.8 1.9 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EWC44501.1 - 2e-07 30.6 1.3 2e-07 30.6 1.3 2.4 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain VPS38 PF17649.1 EWC44501.1 - 0.054 12.4 0.1 0.063 12.1 0.1 1.0 1 0 0 1 1 1 0 Vacuolar protein sorting 38 SET PF00856.28 EWC44502.1 - 2e-10 41.3 6.4 2.4e-10 41.1 0.1 3.3 2 2 1 3 3 3 1 SET domain DUF4620 PF15399.6 EWC44502.1 - 0.083 13.2 0.2 0.16 12.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4620) Sec7 PF01369.20 EWC44503.1 - 1.5e-32 112.8 0.9 2.5e-32 112.1 0.9 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EWC44503.1 - 5.4e-07 30.1 0.1 2.3e-06 28.0 0.1 2.2 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EWC44503.1 - 0.00016 22.0 0.1 0.00044 20.6 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain CDC45 PF02724.14 EWC44503.1 - 3.4 5.8 15.7 7.3 4.8 15.7 1.5 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M14 PF00246.24 EWC44504.1 - 8.3e-74 249.0 0.0 1.3e-73 248.3 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase OCRL_clath_bd PF16726.5 EWC44504.1 - 0.19 11.9 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 Inositol polyphosphate 5-phosphatase clathrin binding domain Ribosomal_L14 PF00238.19 EWC44505.1 - 1.2e-48 164.2 3.3 1.3e-48 164.1 3.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Pkinase PF00069.25 EWC44506.1 - 2.1e-71 240.4 0.0 2.6e-71 240.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44506.1 - 7.6e-37 127.0 0.0 1e-36 126.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC44506.1 - 4e-06 26.4 0.0 5.5e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like MAGE_N PF12440.8 EWC44506.1 - 1.7 9.4 5.3 3.4 8.4 5.3 1.6 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Spem1 PF15670.5 EWC44507.1 - 3.9 7.0 13.4 1.4 8.5 0.4 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 DUF2220 PF09983.9 EWC44507.1 - 5.5 6.3 12.1 0.24 10.8 3.9 2.3 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) MCM3AP_GANP PF16769.5 EWC44507.1 - 7.3 4.7 8.6 12 3.9 8.6 1.3 1 0 0 1 1 1 0 MCM3AP domain of GANP CLASP_N PF12348.8 EWC44508.1 - 0.00045 19.9 2.7 0.0048 16.5 0.4 2.9 3 0 0 3 3 3 1 CLASP N terminal GRIP PF01465.20 EWC44508.1 - 0.26 11.3 1.0 44 4.1 0.1 3.5 3 0 0 3 3 3 0 GRIP domain ParcG PF10274.9 EWC44508.1 - 0.37 10.9 2.3 7.2 6.7 0.0 3.3 4 0 0 4 4 4 0 Parkin co-regulated protein EPO_TPO PF00758.18 EWC44508.1 - 0.98 9.4 4.5 0.68 10.0 1.5 2.3 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin Ecl1 PF12855.7 EWC44509.1 - 4.3e-29 102.9 18.8 4.3e-29 102.9 18.8 2.3 2 0 0 2 2 2 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 EWC44509.1 - 0.00049 20.1 0.5 0.00097 19.2 0.5 1.4 1 0 0 1 1 1 1 MYND finger YL1 PF05764.13 EWC44510.1 - 5.8e-57 193.6 38.2 1e-56 192.8 38.2 1.4 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.11 EWC44510.1 - 1.1e-10 41.1 0.1 1.6e-10 40.5 0.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain PUF PF00806.19 EWC44511.1 - 1.2e-29 100.3 0.0 0.00012 21.5 0.0 5.9 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EWC44511.1 - 9.6e-11 41.4 0.0 2.3e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2811 PF10929.8 EWC44511.1 - 0.099 12.9 0.1 0.22 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) NicO PF03824.16 EWC44512.1 - 1.1e-61 208.7 13.0 1.1e-61 208.7 13.0 1.4 2 0 0 2 2 2 1 High-affinity nickel-transport protein Tom6 PF17112.5 EWC44512.1 - 0.0075 15.7 0.0 0.021 14.3 0.0 1.8 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal DHHC PF01529.20 EWC44512.1 - 5.1 7.2 6.2 46 4.1 1.0 3.2 3 0 0 3 3 3 0 DHHC palmitoyltransferase MBOAT PF03062.19 EWC44513.1 - 2.4e-22 79.8 13.9 3.3e-22 79.3 13.9 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EWC44513.1 - 0.0017 18.6 1.2 0.0017 18.6 1.2 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family CAAD PF14159.6 EWC44513.1 - 2 8.3 4.3 1.1 9.1 0.1 2.7 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase mRNA_cap_enzyme PF01331.19 EWC44514.1 - 4.9e-56 189.7 0.4 6.4e-56 189.3 0.4 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EWC44514.1 - 8.1e-33 113.3 0.2 1.7e-32 112.3 0.2 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EWC44514.1 - 1.7e-10 40.9 0.2 2e-05 24.4 0.1 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EWC44514.1 - 0.0035 17.7 0.1 0.0053 17.1 0.1 1.3 1 0 0 1 1 1 1 RNA ligase RNA_pol_3_Rpc31 PF11705.8 EWC44515.1 - 1e-47 163.3 17.6 1.3e-47 163.0 17.6 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 TFIIA PF03153.13 EWC44515.1 - 0.49 10.3 12.3 0.55 10.2 12.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3445 PF11927.8 EWC44516.1 - 3.2e-66 223.2 0.0 4e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) DUF4719 PF15843.5 EWC44517.1 - 0.53 10.4 2.9 0.77 9.8 2.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) F-box PF00646.33 EWC44518.1 - 0.00015 21.6 0.1 0.0003 20.6 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EWC44518.1 - 0.005 16.7 0.2 0.0099 15.7 0.2 1.5 1 0 0 1 1 1 1 F-box-like YbjQ_1 PF01906.17 EWC44519.1 - 2.6e-28 98.7 0.4 3.3e-28 98.4 0.4 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding ECH_1 PF00378.20 EWC44521.1 - 2.9e-19 69.4 0.0 3.1e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EWC44521.1 - 6.8e-05 22.5 0.0 0.00018 21.1 0.0 1.5 1 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EWC44521.1 - 0.15 12.0 0.0 7.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 THOC2_N PF16134.5 EWC44524.1 - 3.7e-180 600.7 0.0 1e-179 599.2 0.0 1.7 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EWC44524.1 - 5.1e-89 298.4 0.9 1e-88 297.4 0.9 1.6 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EWC44524.1 - 2e-26 91.8 0.0 1.5e-25 89.1 0.0 2.3 2 0 0 2 2 2 1 Transcription- and export-related complex subunit Autophagy_N PF03986.13 EWC44525.1 - 8.5e-44 148.8 0.1 8.5e-44 148.8 0.1 2.0 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 EWC44525.1 - 3e-16 58.6 0.5 5.7e-16 57.7 0.5 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 EWC44525.1 - 1.6e-11 44.6 0.0 3e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain VASt PF16016.5 EWC44526.1 - 3.9e-34 118.3 0.0 6.7e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EWC44526.1 - 2e-23 82.5 0.0 3.3e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DivIC PF04977.15 EWC44527.1 - 0.0084 15.9 1.1 0.0084 15.9 1.1 2.2 3 0 0 3 3 3 1 Septum formation initiator MIT PF04212.18 EWC44527.1 - 0.24 11.5 6.8 0.32 11.1 0.8 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain YabA PF06156.13 EWC44527.1 - 0.25 12.0 6.2 0.48 11.1 0.3 2.5 2 0 0 2 2 2 0 Initiation control protein YabA bZIP_1 PF00170.21 EWC44527.1 - 1.2 9.3 4.2 0.47 10.6 0.4 2.2 2 0 0 2 2 2 0 bZIP transcription factor Methyltransf_23 PF13489.6 EWC44528.1 - 8.5e-21 74.5 0.0 1.1e-20 74.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC44528.1 - 4.1e-15 56.3 0.0 7.8e-15 55.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44528.1 - 1.8e-13 51.0 0.0 6.7e-12 46.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC44528.1 - 9.6e-13 48.6 0.0 4.9e-12 46.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44528.1 - 5.8e-12 45.7 0.0 6.8e-11 42.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EWC44528.1 - 0.00017 21.1 0.0 0.00057 19.4 0.0 1.7 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EWC44528.1 - 0.00031 20.3 0.0 0.0087 15.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EWC44528.1 - 0.0039 17.0 0.0 0.0098 15.6 0.0 1.6 2 0 0 2 2 2 1 Lysine methyltransferase DREV PF05219.12 EWC44528.1 - 0.0055 15.8 0.0 0.0086 15.2 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_PK PF05891.12 EWC44528.1 - 0.0065 16.0 0.0 0.026 14.0 0.0 1.8 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_24 PF13578.6 EWC44528.1 - 0.0093 17.0 0.0 0.014 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EWC44528.1 - 0.26 11.3 0.0 0.39 10.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain CS PF04969.16 EWC44529.1 - 1.6e-16 61.1 0.0 4.2e-16 59.7 0.0 1.7 1 0 0 1 1 1 1 CS domain Auxin_repressed PF05564.12 EWC44531.1 - 0.0009 19.9 0.7 0.0016 19.1 0.7 1.4 1 0 0 1 1 1 1 Dormancy/auxin associated protein PRP38_assoc PF12871.7 EWC44531.1 - 0.29 11.7 6.1 0.59 10.8 6.1 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Img2 PF05046.14 EWC44532.1 - 5.9e-18 64.9 0.0 8e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) AMP-binding PF00501.28 EWC44533.1 - 2.7e-71 240.4 0.0 4.3e-71 239.7 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC44533.1 - 1.2e-14 55.0 0.3 2.7e-14 53.9 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain WD40 PF00400.32 EWC44534.1 - 2.5e-21 75.6 7.0 0.00025 21.8 0.0 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC44534.1 - 7e-12 45.5 0.0 0.014 15.7 0.0 4.9 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EWC44534.1 - 0.012 15.0 0.0 16 4.7 0.0 3.5 3 1 0 3 3 3 0 WD40-like domain SNase PF00565.17 EWC44535.1 - 7.9e-65 216.1 3.6 6.4e-23 81.3 0.0 5.7 6 0 0 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EWC44535.1 - 1e-25 90.1 0.0 7.6e-25 87.3 0.0 2.1 2 0 0 2 2 2 1 Tudor domain SMN PF06003.12 EWC44535.1 - 1.9e-06 27.4 0.0 3.8e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Agenet PF05641.12 EWC44535.1 - 0.0087 16.5 0.0 0.031 14.7 0.0 2.0 1 0 0 1 1 1 1 Agenet domain DUF3297 PF11730.8 EWC44535.1 - 0.14 12.1 0.0 0.5 10.3 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) Recep_L_domain PF01030.24 EWC44536.1 - 1.4e-11 44.5 2.1 0.0068 16.5 0.2 4.7 2 2 2 4 4 4 4 Receptor L domain LRR_5 PF13306.6 EWC44536.1 - 0.0003 20.8 0.3 0.019 14.9 0.4 2.9 3 0 0 3 3 3 1 BspA type Leucine rich repeat region (6 copies) S100PBPR PF15427.6 EWC44536.1 - 0.19 11.0 0.0 0.59 9.3 0.0 1.7 1 1 1 2 2 2 0 S100P-binding protein DUF1752 PF08550.10 EWC44537.1 - 1.2e-11 44.2 0.8 2.9e-11 43.0 0.8 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) EMC1_C PF07774.13 EWC44538.1 - 6.6e-70 235.1 0.0 1.6e-69 233.8 0.0 1.7 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EWC44538.1 - 4e-16 59.3 7.5 1.9e-11 44.0 1.6 3.3 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 EWC44538.1 - 0.01 15.7 3.6 1.1e+02 3.0 0.0 6.3 7 0 0 7 7 7 0 PQQ enzyme repeat DUF777 PF05606.11 EWC44538.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF777) IMS PF00817.20 EWC44539.1 - 8.1e-46 155.7 0.0 1.4e-45 155.0 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 EWC44539.1 - 1.2e-11 44.0 1.6 2.6e-11 42.9 1.6 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 EWC44539.1 - 4.9e-10 40.1 0.0 1.4e-09 38.7 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EWC44539.1 - 0.034 14.5 0.0 0.089 13.2 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif AT_hook PF02178.19 EWC44539.1 - 0.084 12.8 4.9 0.32 11.0 4.9 2.1 1 0 0 1 1 1 0 AT hook motif BORCS7 PF16088.5 EWC44540.1 - 0.0025 18.1 0.3 0.0032 17.7 0.3 1.2 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 7 DDOST_48kD PF03345.14 EWC44541.1 - 5.1e-139 463.7 0.0 5.8e-139 463.5 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta 2OG-FeII_Oxy_2 PF13532.6 EWC44543.1 - 1.7e-17 64.3 0.0 2.9e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EWC44544.1 - 0.00094 19.0 0.3 0.0022 17.8 0.3 1.7 1 0 0 1 1 1 1 F-box-like Ank_2 PF12796.7 EWC44545.1 - 2.6e-93 306.7 2.6 1.9e-20 73.3 0.0 7.7 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC44545.1 - 5.3e-79 259.7 1.0 4.9e-13 49.3 0.0 9.7 6 3 5 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC44545.1 - 2e-70 224.3 1.5 2.4e-06 27.4 0.0 15.1 15 0 0 15 15 15 13 Ankyrin repeat Ank PF00023.30 EWC44545.1 - 5.5e-70 229.0 15.8 4.2e-07 30.1 0.0 14.8 14 1 1 15 15 15 13 Ankyrin repeat Ank_5 PF13857.6 EWC44545.1 - 8.1e-66 217.2 6.0 1.4e-08 34.8 0.0 12.6 5 3 8 13 13 13 13 Ankyrin repeats (many copies) Plectin PF00681.20 EWC44545.1 - 0.024 14.5 0.0 22 5.0 0.0 4.3 5 0 0 5 5 5 0 Plectin repeat AAA PF00004.29 EWC44546.1 - 1.7e-33 115.9 0.0 5.6e-33 114.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC44546.1 - 1.2e-10 41.0 0.0 2.9e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EWC44546.1 - 2.9e-07 31.0 0.3 9.7e-06 26.1 0.2 2.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EWC44546.1 - 3.7e-05 23.7 0.0 0.00015 21.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EWC44546.1 - 4.2e-05 22.8 0.0 7.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 EWC44546.1 - 0.0011 19.2 0.1 0.0077 16.4 0.0 2.4 2 1 1 3 3 3 1 AAA domain AAA_24 PF13479.6 EWC44546.1 - 0.0016 18.2 0.0 0.0032 17.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EWC44546.1 - 0.0018 18.6 0.0 0.0048 17.3 0.0 1.8 1 1 0 1 1 1 1 RNA helicase AAA_22 PF13401.6 EWC44546.1 - 0.0032 17.7 0.3 0.11 12.8 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_11 PF13086.6 EWC44546.1 - 0.0033 17.2 0.0 0.0073 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EWC44546.1 - 0.004 17.2 0.0 0.0068 16.4 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EWC44546.1 - 0.0043 17.6 0.0 0.078 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EWC44546.1 - 0.0058 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC44546.1 - 0.013 15.2 0.2 0.043 13.5 0.2 1.9 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EWC44546.1 - 0.017 14.9 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RuvB_N PF05496.12 EWC44546.1 - 0.023 14.5 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 EWC44546.1 - 0.032 14.1 0.0 0.054 13.4 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_7 PF12775.7 EWC44546.1 - 0.057 12.9 0.1 0.14 11.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_6 PF12774.7 EWC44546.1 - 0.058 12.3 0.1 0.093 11.7 0.1 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_19 PF13245.6 EWC44546.1 - 0.073 13.4 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EWC44546.1 - 0.082 12.8 0.0 0.28 11.1 0.0 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EWC44546.1 - 0.14 11.5 0.1 0.3 10.4 0.1 1.5 1 0 0 1 1 1 0 KaiC AAA PF00004.29 EWC44547.1 - 6.3e-33 114.0 0.0 1.3e-32 113.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EWC44547.1 - 5.3e-06 25.9 0.0 1.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EWC44547.1 - 7.3e-05 23.2 3.1 0.033 14.6 0.0 3.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EWC44547.1 - 0.00017 21.9 0.1 0.0096 16.2 0.0 3.1 1 1 2 3 3 3 1 AAA domain RuvB_N PF05496.12 EWC44547.1 - 0.00019 21.2 0.0 0.00039 20.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EWC44547.1 - 0.00057 20.4 0.0 0.0014 19.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EWC44547.1 - 0.00076 19.2 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 EWC44547.1 - 0.0042 17.1 0.0 0.034 14.2 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EWC44547.1 - 0.0062 16.7 0.0 0.024 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EWC44547.1 - 0.0084 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 EWC44547.1 - 0.0087 16.3 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EWC44547.1 - 0.012 14.8 0.0 0.024 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EWC44547.1 - 0.017 15.5 0.0 0.059 13.8 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.6 EWC44547.1 - 0.02 15.3 0.0 0.071 13.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EWC44547.1 - 0.022 14.8 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EWC44547.1 - 0.035 14.1 0.0 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 EWC44547.1 - 0.041 13.9 0.0 0.51 10.4 0.0 2.8 3 0 0 3 3 2 0 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 EWC44547.1 - 0.042 13.2 0.1 1.2 8.4 0.1 2.3 1 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 EWC44547.1 - 0.097 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Bac_DnaA PF00308.18 EWC44547.1 - 0.12 12.2 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_24 PF13479.6 EWC44547.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain EzrA PF06160.12 EWC44548.1 - 0.028 12.6 0.0 0.036 12.3 0.0 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA SlyX PF04102.12 EWC44548.1 - 0.072 13.7 0.2 0.11 13.2 0.2 1.3 1 0 0 1 1 1 0 SlyX Pyr_redox_2 PF07992.14 EWC44549.1 - 1.8e-29 102.9 0.0 2.2e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EWC44549.1 - 7.4e-09 36.1 0.5 1.9e-06 28.3 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC44549.1 - 0.00018 21.5 0.0 0.35 10.8 0.0 3.6 4 0 0 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 EWC44549.1 - 0.00037 20.2 5.4 0.16 11.6 0.0 3.4 3 1 1 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.17 EWC44549.1 - 0.0025 17.1 1.4 0.59 9.3 0.2 2.3 2 0 0 2 2 2 2 Thi4 family Pyr_redox_3 PF13738.6 EWC44549.1 - 0.013 14.8 0.0 0.085 12.1 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EWC44549.1 - 0.024 13.8 0.1 0.085 12.0 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EWC44549.1 - 0.036 13.1 0.5 0.15 11.1 0.0 2.2 2 1 1 3 3 3 0 Lycopene cyclase protein NAD_binding_8 PF13450.6 EWC44549.1 - 0.57 10.5 2.5 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EWC44549.1 - 1.4 7.7 3.2 4 6.2 0.7 2.2 2 1 0 2 2 2 0 Tryptophan halogenase Fungal_trans PF04082.18 EWC44550.1 - 1.8e-09 37.0 0.0 3.4e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DHHC PF01529.20 EWC44551.1 - 1.1e-25 90.3 5.1 1.1e-25 90.3 5.1 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase COX4_pro_2 PF07835.12 EWC44551.1 - 0.074 13.2 3.5 0.17 12.0 3.5 1.6 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV Topo_Zn_Ribbon PF08272.11 EWC44551.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Topoisomerase I zinc-ribbon-like KAR9 PF08580.10 EWC44551.1 - 1.2 7.6 2.8 1.7 7.1 2.8 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 OTT_1508_deam PF14441.6 EWC44552.1 - 2.3e-07 30.7 0.1 9.8e-07 28.7 0.0 2.0 2 0 0 2 2 2 1 OTT_1508-like deaminase CNH PF00780.22 EWC44553.1 - 4.7e-81 272.4 0.0 1.4e-80 270.9 0.0 1.7 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 EWC44553.1 - 4.5e-46 156.3 0.0 4.5e-46 156.3 0.0 2.2 2 1 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.20 EWC44553.1 - 1.3e-39 136.4 0.1 2e-39 135.7 0.1 1.3 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EWC44553.1 - 1.8e-13 50.3 0.0 4.1e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_13 PF16652.5 EWC44553.1 - 0.00052 19.9 0.3 0.0081 16.0 0.0 2.8 3 1 0 3 3 3 1 Pleckstrin homology domain ATP-synt_C PF00137.21 EWC44554.1 - 6.7e-31 106.4 35.0 3.7e-20 72.0 13.4 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Pkinase PF00069.25 EWC44555.1 - 1.1e-62 211.8 0.0 1.4e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44555.1 - 2.4e-33 115.5 0.0 4.2e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC44555.1 - 8.3e-07 28.6 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EWC44555.1 - 9.9e-05 21.8 0.0 0.00068 19.0 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EWC44555.1 - 0.002 17.0 0.0 0.0044 15.8 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EWC44555.1 - 0.0026 16.8 0.0 0.0038 16.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EWC44555.1 - 0.0037 17.2 0.0 0.01 15.8 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Rad21_Rec8 PF04824.16 EWC44555.1 - 0.042 13.1 0.0 0.092 12.1 0.0 1.5 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein AMP-binding PF00501.28 EWC44556.1 - 1.7e-93 313.6 0.0 2.3e-93 313.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC44556.1 - 1.5e-20 73.9 0.0 3.5e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CRT10 PF08728.10 EWC44557.1 - 2.4e-23 82.3 0.0 1.2e-18 66.8 0.0 2.2 2 0 0 2 2 2 2 CRT10 YL1 PF05764.13 EWC44557.1 - 2.7 8.1 5.5 3.8 7.6 5.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 EWC44557.1 - 8.2 4.5 5.1 11 4.1 5.1 1.1 1 0 0 1 1 1 0 Nop14-like family NAD_binding_1 PF00175.21 EWC44558.1 - 2.5e-06 28.1 0.0 4.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EWC44558.1 - 1.7e-05 25.1 0.0 4.8e-05 23.6 0.0 1.9 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EWC44558.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.6 1 1 1 2 2 2 0 Ferric reductase NAD binding domain Sld7_C PF18596.1 EWC44559.1 - 7.8e-16 58.0 0.1 1.5e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 Sld7 C-terminal domain Sld7_N PF18636.1 EWC44559.1 - 0.046 14.1 0.1 0.11 12.8 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain Chorismate_bind PF00425.18 EWC44560.1 - 2.4e-65 220.7 0.0 9.6e-65 218.7 0.0 2.0 1 1 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EWC44560.1 - 6e-31 107.7 0.0 9.7e-31 107.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EWC44560.1 - 2.5e-14 53.7 0.0 6.5e-14 52.3 0.0 1.7 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EWC44560.1 - 5.8e-08 32.7 0.0 1.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 GPP34 PF05719.11 EWC44560.1 - 0.044 13.8 0.4 0.12 12.4 0.4 1.7 1 0 0 1 1 1 0 Golgi phosphoprotein 3 (GPP34) Vps55 PF04133.14 EWC44561.1 - 3.9e-45 152.6 8.4 4.4e-45 152.4 8.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Proteasome PF00227.26 EWC44562.1 - 1.4e-49 168.2 0.0 1.7e-49 167.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EWC44562.1 - 7.1e-12 44.8 0.1 1.3e-11 44.0 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TRAPPC9-Trs120 PF08626.11 EWC44563.1 - 0 1213.8 0.0 0 1213.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF3684 PF12449.8 EWC44564.1 - 0 1251.1 0.0 0 1251.1 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EWC44564.1 - 0.0066 16.3 0.0 0.026 14.3 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Reprolysin_4 PF13583.6 EWC44564.1 - 0.19 11.4 0.1 0.35 10.5 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF3402 PF11882.8 EWC44565.1 - 4.3e-154 514.0 0.0 5.9e-154 513.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EWC44565.1 - 7.2e-91 304.4 0.0 1.2e-90 303.7 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein Astro_capsid_N PF03115.14 EWC44565.1 - 0.025 13.2 0.1 0.038 12.6 0.1 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Sugar_tr PF00083.24 EWC44566.1 - 9.3e-73 245.6 24.2 1.1e-72 245.3 24.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC44566.1 - 4.2e-21 75.2 28.1 6.8e-21 74.6 28.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EWC44566.1 - 1.8e-10 40.0 17.3 5.5e-06 25.2 4.2 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein Phage_holin_2_4 PF16082.5 EWC44566.1 - 0.0058 16.3 5.1 0.028 14.1 0.2 2.8 2 0 0 2 2 2 1 Bacteriophage holin family, superfamily II-like Ndc1_Nup PF09531.10 EWC44566.1 - 5 5.7 7.0 9.2 4.8 7.0 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup IPPT PF01715.17 EWC44567.1 - 1.1e-62 211.8 0.0 1.4e-62 211.5 0.0 1.0 1 0 0 1 1 1 1 IPP transferase DUF1479 PF07350.12 EWC44568.1 - 5.8e-149 496.4 0.0 6.6e-149 496.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 EWC44568.1 - 0.0008 19.7 0.1 0.35 11.1 0.1 2.2 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) PAP2 PF01569.21 EWC44569.1 - 1.3e-16 60.6 4.4 6.3e-16 58.4 4.4 2.0 1 1 0 1 1 1 1 PAP2 superfamily UbiA PF01040.18 EWC44569.1 - 0.0098 15.2 3.6 0.012 14.9 1.2 2.0 2 0 0 2 2 2 1 UbiA prenyltransferase family DUF212 PF02681.14 EWC44569.1 - 0.036 14.2 1.1 0.38 10.9 0.0 2.2 1 1 1 2 2 2 0 Divergent PAP2 family DUF4203 PF13886.6 EWC44569.1 - 0.062 13.0 7.1 0.064 12.9 3.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) Longin PF13774.6 EWC44570.1 - 1.5e-26 92.2 0.7 2.8e-26 91.4 0.7 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EWC44570.1 - 2.4e-16 59.3 0.0 3.8e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.12 EWC44570.1 - 0.045 13.8 1.2 0.092 12.8 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ASXH PF13919.6 EWC44572.1 - 3.4e-21 75.7 0.2 5e-21 75.2 0.2 1.2 1 0 0 1 1 1 1 Asx homology domain CENP-I PF07778.11 EWC44573.1 - 1.5e-41 142.7 0.2 5e-41 141.0 0.2 1.7 1 1 0 1 1 1 1 Mis6 TetR PF13972.6 EWC44573.1 - 0.028 14.1 0.1 0.14 11.9 0.1 2.2 1 0 0 1 1 1 0 Bacterial transcriptional repressor Glyco_hydro_3 PF00933.21 EWC44574.1 - 1.3e-37 129.9 0.0 1.7e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 EWC44574.1 - 3.4e-06 27.3 0.0 2.6e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EWC44574.1 - 0.00066 20.0 0.0 0.002 18.5 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EWC44574.1 - 0.0082 16.1 0.0 0.024 14.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Glyco_hydro_3_C PF01915.22 EWC44574.1 - 0.022 14.7 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_CG PF14542.6 EWC44574.1 - 0.067 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EWC44574.1 - 0.11 12.6 0.0 0.94 9.6 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF4733 PF15878.5 EWC44575.1 - 0.23 12.0 0.8 1.4 9.4 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4733) FRG2 PF15315.6 EWC44575.1 - 5.8 7.1 21.7 0.094 12.9 10.4 2.1 2 0 0 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 Abhydrolase_1 PF00561.20 EWC44576.1 - 7.4e-15 55.3 0.0 2e-13 50.6 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC44576.1 - 7.7e-13 48.3 0.0 1.2e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 VirJ PF06057.11 EWC44576.1 - 0.036 13.9 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF3818 PF12825.7 EWC44577.1 - 1.4e-53 182.1 0.5 6.2e-32 111.0 0.1 2.5 2 1 1 3 3 3 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EWC44577.1 - 1e-35 122.6 0.0 2e-35 121.6 0.0 1.5 1 0 0 1 1 1 1 PX-associated Lgl_C PF08596.10 EWC44578.1 - 5.3e-85 285.5 0.0 5.4e-59 199.9 0.0 2.4 2 0 0 2 2 2 2 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 EWC44578.1 - 2.1e-05 24.7 0.0 3.3 8.1 0.0 5.8 6 1 0 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Lipase_C PF18067.1 EWC44578.1 - 0.11 13.1 0.0 0.43 11.2 0.0 2.0 1 0 0 1 1 1 0 Lipase C-terminal domain SHMT PF00464.19 EWC44579.1 - 9.6e-206 683.0 0.0 1.1e-205 682.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 EWC44579.1 - 0.038 13.3 0.2 0.11 11.7 0.2 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EWC44579.1 - 0.068 11.7 0.0 0.1 11.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Baculo_DNA_bind PF04786.12 EWC44579.1 - 0.19 11.0 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 ssDNA binding protein Med9 PF07544.13 EWC44580.1 - 2.7e-19 69.0 0.5 5e-19 68.2 0.5 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 EWC44580.1 - 0.014 15.7 10.3 0.024 14.9 10.3 1.7 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF16 PF01519.16 EWC44580.1 - 0.039 14.5 0.7 0.069 13.6 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 Spc29 PF17082.5 EWC44580.1 - 0.064 13.1 0.2 0.099 12.5 0.2 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 Atg14 PF10186.9 EWC44580.1 - 0.09 11.8 1.2 0.11 11.5 1.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.10 EWC44580.1 - 0.1 12.8 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Osmo_CC PF08946.10 EWC44580.1 - 0.35 11.1 6.2 0.83 9.9 6.2 1.6 1 0 0 1 1 1 0 Osmosensory transporter coiled coil iPGM_N PF06415.13 EWC44581.1 - 2.9e-75 252.4 0.0 3.9e-75 252.0 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EWC44581.1 - 2.8e-72 243.1 0.0 3.2e-72 242.9 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EWC44581.1 - 6.2e-05 22.5 0.0 0.00094 18.7 0.0 2.3 1 1 0 1 1 1 1 Sulfatase DUF4973 PF16343.5 EWC44581.1 - 0.023 14.8 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4973) Phosphodiest PF01663.22 EWC44581.1 - 0.024 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Alk_phosphatase PF00245.20 EWC44581.1 - 0.13 11.2 0.0 0.26 10.2 0.0 1.4 1 0 0 1 1 1 0 Alkaline phosphatase Metallophos PF00149.28 EWC44582.1 - 1.6e-15 58.2 0.6 3.1e-15 57.2 0.6 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TC1 PF15063.6 EWC44582.1 - 0.13 12.1 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Thyroid cancer protein 1 zf-RING_2 PF13639.6 EWC44583.1 - 1.7e-08 34.7 5.6 1.7e-08 34.7 5.6 2.1 2 0 0 2 2 2 1 Ring finger domain Prok-RING_1 PF14446.6 EWC44583.1 - 0.00025 20.9 2.6 0.00025 20.9 2.6 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 1 FANCL_C PF11793.8 EWC44583.1 - 0.0003 20.9 7.1 0.0014 18.8 4.2 2.4 2 0 0 2 2 2 1 FANCL C-terminal domain SWIM PF04434.17 EWC44583.1 - 0.0011 18.6 0.1 0.0021 17.7 0.1 1.4 1 0 0 1 1 1 1 SWIM zinc finger zf-RING_5 PF14634.6 EWC44583.1 - 0.0012 18.8 6.1 0.0012 18.8 6.1 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EWC44583.1 - 0.0023 17.7 4.1 0.0062 16.4 4.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC44583.1 - 0.0085 16.1 4.6 0.03 14.4 4.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 EWC44583.1 - 0.0092 15.8 5.3 0.022 14.5 5.3 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain FYVE_2 PF02318.16 EWC44583.1 - 0.0098 16.1 1.6 0.021 15.0 1.6 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger zf-rbx1 PF12678.7 EWC44583.1 - 0.012 15.8 7.1 0.14 12.4 0.8 3.4 4 0 0 4 4 3 0 RING-H2 zinc finger domain C1_1 PF00130.22 EWC44583.1 - 0.019 14.9 2.3 0.019 14.9 2.3 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RINGv PF12906.7 EWC44583.1 - 0.023 14.8 5.2 0.12 12.5 5.7 2.0 2 0 0 2 2 2 0 RING-variant domain PHD PF00628.29 EWC44583.1 - 0.024 14.5 5.0 0.1 12.5 5.0 2.0 1 1 1 2 2 2 0 PHD-finger zf-ANAPC11 PF12861.7 EWC44583.1 - 0.027 14.5 2.0 0.027 14.5 2.0 2.2 3 0 0 3 3 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Cys_Knot_tox PF17486.2 EWC44583.1 - 0.16 12.2 8.3 0.12 12.6 5.7 2.1 2 0 0 2 2 2 0 Cystine knot toxins Spore_coat_CotO PF14153.6 EWC44583.1 - 3.6 7.5 10.5 5.7 6.8 10.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO HATPase_c PF02518.26 EWC44585.1 - 2.6e-26 92.3 0.1 5.3e-26 91.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EWC44585.1 - 9.3e-22 76.8 0.6 2.5e-21 75.5 0.1 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EWC44585.1 - 1.1e-18 67.4 0.0 2.2e-12 47.1 0.0 2.5 2 0 0 2 2 2 2 Response regulator receiver domain MFS_1 PF07690.16 EWC44586.1 - 2.5e-38 131.9 69.4 4.5e-38 131.1 64.6 3.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EWC44586.1 - 1.2e-20 73.5 13.8 1.2e-20 73.5 13.8 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EWC44586.1 - 5.3e-14 51.9 13.1 5.3e-14 51.9 13.1 2.6 3 1 0 3 3 3 2 Sugar (and other) transporter MSA-2c PF12238.8 EWC44587.1 - 0.036 14.1 14.6 0.92 9.5 9.0 2.2 2 0 0 2 2 2 0 Merozoite surface antigen 2c Vasculin PF15337.6 EWC44587.1 - 0.12 13.2 0.0 0.31 11.9 0.0 1.6 1 0 0 1 1 1 0 Vascular protein family Vasculin-like 1 PX PF00787.24 EWC44588.1 - 4.6e-19 68.5 0.0 6.5e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 PX domain PACT_coil_coil PF10495.9 EWC44590.1 - 4.2e-20 72.1 2.8 4.2e-20 72.1 2.8 4.0 3 1 0 3 3 3 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc7 PF08317.11 EWC44590.1 - 0.0022 16.9 93.0 0.016 14.1 25.2 4.9 1 1 4 5 5 5 4 Spc7 kinetochore protein DUF3584 PF12128.8 EWC44590.1 - 0.2 9.2 91.0 0.31 8.5 23.0 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) MscS_porin PF12795.7 EWC44590.1 - 7.2 6.1 99.1 2.6 7.5 22.5 4.0 1 1 1 3 3 3 0 Mechanosensitive ion channel porin domain IL10 PF00726.17 EWC44590.1 - 8.5 5.9 10.8 3 7.3 0.1 3.4 4 0 0 4 4 4 0 Interleukin 10 Cnn_1N PF07989.11 EWC44591.1 - 4.9e-25 87.5 5.4 4.9e-25 87.5 5.4 8.9 4 2 2 6 6 6 2 Centrosomin N-terminal motif 1 Golgin_A5 PF09787.9 EWC44591.1 - 0.11 11.9 93.7 2.9 7.3 11.8 5.1 1 1 3 4 4 4 0 Golgin subfamily A member 5 WD40_alt PF14077.6 EWC44591.1 - 0.3 11.0 8.7 8.3 6.4 1.0 5.1 4 1 0 4 4 4 0 Alternative WD40 repeat motif SUIM_assoc PF16619.5 EWC44591.1 - 0.55 10.3 0.0 0.55 10.3 0.0 3.4 2 2 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 APG6_N PF17675.1 EWC44591.1 - 1.7 9.2 110.0 0.26 11.8 14.8 6.1 1 1 5 6 6 6 0 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 EWC44591.1 - 2.7 8.1 91.9 3 7.9 22.5 6.3 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein Glyco_hydro_17 PF00332.18 EWC44592.1 - 1.8e-05 24.5 0.0 3.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 PP28 PF10252.9 EWC44594.1 - 6.3e-21 74.6 23.5 1.3e-19 70.4 23.5 2.4 1 1 0 1 1 1 1 Casein kinase substrate phosphoprotein PP28 CENP-B_dimeris PF09026.10 EWC44594.1 - 7.4 7.0 13.2 16 5.9 10.6 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Acyltransferase PF01553.21 EWC44597.1 - 1.1e-11 44.4 0.0 2.5e-10 40.1 0.0 2.5 1 1 0 1 1 1 1 Acyltransferase Nup96 PF12110.8 EWC44598.1 - 3.7e-88 295.4 0.1 5.4e-88 294.9 0.1 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EWC44598.1 - 8.6e-47 159.0 0.0 1.4e-46 158.3 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EWC44598.1 - 9.7e-23 80.8 172.3 7.8e-11 42.7 29.4 11.6 5 2 7 12 12 12 8 Nucleoporin FG repeat region EF-hand_1 PF00036.32 EWC44599.1 - 1.4e-19 68.1 8.9 1.5e-07 30.5 0.4 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EWC44599.1 - 1.7e-17 63.6 5.9 2.7e-13 50.2 0.6 2.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EWC44599.1 - 2e-17 61.5 5.3 5.4e-06 25.9 0.4 3.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EWC44599.1 - 2.5e-14 52.9 9.2 1e-11 44.5 0.9 3.6 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EWC44599.1 - 9e-08 31.3 9.9 0.0014 18.1 0.7 3.4 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 EWC44599.1 - 0.0016 18.4 1.1 0.054 13.5 0.1 2.3 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF1296 PF06972.11 EWC44599.1 - 0.0058 16.8 0.9 3.5 7.8 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1296) SPARC_Ca_bdg PF10591.9 EWC44599.1 - 0.0074 16.6 0.1 5.6 7.3 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EWC44599.1 - 0.014 15.7 0.0 1.5 9.2 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 EWC44599.1 - 0.037 14.2 0.0 0.7 10.1 0.0 2.2 2 0 0 2 2 2 0 Dockerin type I domain Metal_resist PF13801.6 EWC44599.1 - 0.057 13.6 0.1 0.057 13.6 0.1 2.1 3 0 0 3 3 3 0 Heavy-metal resistance zf-C2H2 PF00096.26 EWC44600.1 - 7.4e-20 70.2 28.0 5.1e-05 23.5 0.9 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC44600.1 - 5.6e-19 67.7 28.6 1.5e-06 28.3 1.2 5.3 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC44600.1 - 8.9e-11 41.7 25.7 0.0041 17.8 0.8 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EWC44600.1 - 2.1e-08 34.3 1.7 0.12 12.7 0.0 4.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EWC44600.1 - 1e-05 25.8 11.9 0.018 15.4 0.4 3.9 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EWC44600.1 - 0.0089 16.2 1.3 1.3 9.2 0.2 2.3 1 1 1 2 2 2 1 Aberrant zinc-finger zf-C2H2_11 PF16622.5 EWC44600.1 - 0.01 15.6 10.0 0.017 14.9 0.4 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EWC44600.1 - 0.28 11.4 7.5 13 6.0 0.1 3.3 2 1 2 4 4 4 0 Zinc ribbon domain DUF2072 PF09845.9 EWC44600.1 - 0.34 11.2 3.0 0.23 11.7 0.2 2.1 2 0 0 2 2 2 0 Zn-ribbon containing protein C1_4 PF07975.12 EWC44600.1 - 0.57 10.4 6.3 0.99 9.7 0.3 2.7 1 1 2 3 3 3 0 TFIIH C1-like domain zf-TRAF PF02176.18 EWC44600.1 - 1.2 9.9 10.9 1.4 9.7 1.9 2.4 2 0 0 2 2 2 0 TRAF-type zinc finger zf-MYST PF17772.1 EWC44600.1 - 2 8.1 4.2 7.1 6.3 0.0 3.1 3 0 0 3 3 3 0 MYST family zinc finger domain XPA_N PF01286.18 EWC44600.1 - 2 8.5 8.9 0.94 9.6 0.5 3.1 4 0 0 4 4 4 0 XPA protein N-terminal DUF2256 PF10013.9 EWC44600.1 - 2.1 8.5 8.0 12 6.1 0.0 3.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-CRD PF17979.1 EWC44600.1 - 4.7 7.3 8.1 2 8.5 1.2 2.2 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions Bromodomain PF00439.25 EWC44601.1 - 3.5e-33 113.5 1.3 2.8e-15 56.1 0.1 2.4 2 0 0 2 2 2 2 Bromodomain Fur_reg_FbpB PF13040.6 EWC44601.1 - 0.0044 16.5 0.1 0.75 9.4 0.0 2.6 2 0 0 2 2 2 2 Fur-regulated basic protein B DUF3445 PF11927.8 EWC44601.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3445) CKS PF01111.19 EWC44602.1 - 3.9e-32 110.3 1.2 8.7e-32 109.2 0.2 1.8 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit Sin3a_C PF16879.5 EWC44603.1 - 3.1e-77 260.1 1.0 1.1e-76 258.3 0.1 2.5 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 EWC44603.1 - 6.6e-44 147.8 9.5 3.9e-18 65.3 0.0 4.3 3 1 1 4 4 4 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EWC44603.1 - 8.1e-43 144.5 0.5 3.2e-42 142.6 0.1 2.2 2 0 0 2 2 2 1 Sin3 family co-repressor Ricin_B_lectin PF00652.22 EWC44605.1 - 0.009 16.3 0.0 0.03 14.6 0.0 1.7 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Rad60-SLD PF11976.8 EWC44606.1 - 1.3e-16 60.2 3.7 2.2e-16 59.4 2.5 2.0 3 0 0 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EWC44606.1 - 6.5e-06 25.8 1.0 4.5e-05 23.1 0.4 2.4 3 0 0 3 3 3 1 Ubiquitin family TUG-UBL1 PF11470.8 EWC44606.1 - 0.00097 19.3 0.0 0.002 18.3 0.0 1.5 1 0 0 1 1 1 1 TUG ubiquitin-like domain Aminotran_3 PF00202.21 EWC44607.1 - 1e-111 373.5 0.0 8.5e-101 337.5 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class-III Aminotran_1_2 PF00155.21 EWC44607.1 - 0.035 13.3 0.0 0.082 12.1 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EWC44607.1 - 0.069 12.4 0.0 0.093 12.0 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Suf PF05843.14 EWC44608.1 - 7.1e-06 26.2 3.3 0.0045 17.0 0.6 3.3 2 1 1 3 3 3 3 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EWC44608.1 - 0.00062 20.4 2.4 9.3 7.4 0.2 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat ERAP1_C PF11838.8 EWC44609.1 - 2.2e-88 296.8 0.4 1.1e-86 291.2 0.0 2.3 2 0 0 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EWC44609.1 - 1.2e-87 293.0 1.9 2e-87 292.3 1.9 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EWC44609.1 - 2.7e-55 187.4 2.6 5.9e-55 186.3 1.9 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Aminotran_3 PF00202.21 EWC44610.1 - 7.6e-93 311.4 0.0 8.6e-93 311.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EWC44610.1 - 0.034 13.3 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II DEAD PF00270.29 EWC44611.1 - 1.9e-46 158.0 0.0 8.3e-46 156.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC44611.1 - 6.7e-29 100.5 0.0 4.9e-28 97.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF2986 PF11661.8 EWC44611.1 - 0.0024 18.4 3.1 0.012 16.2 3.1 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2986) ResIII PF04851.15 EWC44611.1 - 0.0026 17.8 0.0 0.0054 16.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EWC44611.1 - 0.13 11.0 0.0 0.23 10.1 0.0 1.5 2 0 0 2 2 2 0 SNF2 family N-terminal domain His_Phos_1 PF00300.22 EWC44612.1 - 1.2e-13 51.2 0.0 1.6e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) G-patch_2 PF12656.7 EWC44613.1 - 8.4e-23 80.2 0.8 2.6e-22 78.6 0.8 2.0 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 EWC44613.1 - 0.00077 19.3 2.2 0.0019 18.0 2.2 1.7 1 0 0 1 1 1 1 G-patch domain HMG_box PF00505.19 EWC44614.1 - 1.2e-13 51.2 0.5 2.7e-13 50.1 0.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EWC44614.1 - 1.8e-11 44.4 0.5 3.8e-11 43.4 0.5 1.6 1 0 0 1 1 1 1 HMG-box domain SAM_1 PF00536.30 EWC44614.1 - 2.1e-05 24.9 0.1 3.6e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EWC44614.1 - 0.0069 16.5 0.6 0.079 13.1 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) MlaC PF05494.12 EWC44614.1 - 0.0076 16.0 0.3 0.012 15.3 0.3 1.3 1 0 0 1 1 1 1 MlaC protein PPTA PF01239.22 EWC44616.1 - 7.4e-42 139.9 13.0 9e-09 34.8 1.4 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF4219 PF13961.6 EWC44616.1 - 1.2 8.9 8.2 18 5.1 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) DUF1764 PF08576.10 EWC44617.1 - 3.9 8.4 13.6 0.56 11.1 7.4 2.8 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF1764) Gar1 PF04410.14 EWC44617.1 - 6.9 6.4 5.8 17 5.2 5.8 1.5 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region NLE PF08154.12 EWC44618.1 - 7e-21 74.5 0.2 1.3e-20 73.7 0.2 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain WD40 PF00400.32 EWC44618.1 - 3.1e-12 46.8 15.7 0.00017 22.3 0.6 6.1 5 1 0 5 5 5 3 WD domain, G-beta repeat Hemagglutinin PF00509.18 EWC44618.1 - 0.21 9.9 0.0 0.29 9.5 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin GHMP_kinases_N PF00288.26 EWC44619.1 - 5.4e-16 58.6 0.1 1.2e-15 57.5 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EWC44619.1 - 2.8e-08 34.0 0.0 6.3e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal APG5 PF04106.12 EWC44620.1 - 1.3e-56 191.8 0.0 1.8e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 TauD PF02668.16 EWC44620.1 - 1.9e-27 96.7 0.0 3e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NUC130_3NT PF08158.12 EWC44620.1 - 0.027 14.8 0.0 0.8 10.1 0.0 2.7 2 0 0 2 2 2 0 NUC130/3NT domain Sod_Fe_C PF02777.18 EWC44621.1 - 8.2e-20 70.9 0.3 1.1e-10 41.6 0.1 2.9 3 0 0 3 3 3 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EWC44621.1 - 0.035 14.6 0.1 0.068 13.6 0.1 1.5 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain HSP20 PF00011.21 EWC44622.1 - 1.3e-12 47.7 0.1 4.1e-09 36.5 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family End3 PF12761.7 EWC44623.1 - 0.032 14.4 1.8 0.083 13.1 1.8 1.7 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF445 PF04286.12 EWC44623.1 - 0.043 13.6 2.9 0.05 13.4 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF445) CCDC-167 PF15188.6 EWC44623.1 - 0.057 13.8 2.1 0.17 12.3 2.1 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 CENP-F_leu_zip PF10473.9 EWC44623.1 - 0.1 12.6 5.4 0.049 13.7 2.9 1.7 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Response_reg PF00072.24 EWC44625.1 - 7.4e-19 68.0 0.9 1.3e-18 67.2 0.2 1.8 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 EWC44625.1 - 9.4e-16 58.3 0.0 1.6e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EWC44625.1 - 9.5e-07 28.8 0.1 3.4e-06 27.0 0.2 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain WD40 PF00400.32 EWC44626.1 - 6.9e-05 23.5 1.7 0.0002 22.1 1.7 1.8 1 1 0 1 1 1 1 WD domain, G-beta repeat UAF_Rrn10 PF05234.11 EWC44627.1 - 3.3e-07 30.6 0.0 6.7e-07 29.6 0.0 1.6 2 1 0 2 2 2 1 UAF complex subunit Rrn10 Methyltransf_23 PF13489.6 EWC44628.1 - 3.7e-16 59.4 0.0 6.4e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC44628.1 - 1e-14 55.0 0.0 3.5e-14 53.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44628.1 - 5.5e-13 49.4 0.0 1.2e-12 48.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC44628.1 - 5.3e-10 39.8 0.0 1.4e-09 38.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44628.1 - 1.6e-08 34.5 0.0 2.6e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EWC44628.1 - 0.022 14.0 0.0 4.7 6.3 0.0 2.3 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family DUF3419 PF11899.8 EWC44628.1 - 0.03 13.5 0.0 0.045 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) LSM PF01423.22 EWC44629.1 - 1.3e-21 76.0 0.1 1.5e-21 75.9 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EWC44629.1 - 0.0093 16.1 0.0 0.011 15.9 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EWC44629.1 - 0.019 15.1 0.1 0.022 14.8 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain Hfq PF17209.3 EWC44629.1 - 0.055 13.1 0.0 0.068 12.8 0.0 1.2 1 0 0 1 1 1 0 Hfq protein Acetyltransf_1 PF00583.25 EWC44630.1 - 8.8e-07 29.2 0.0 2.2e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC44630.1 - 7.3e-06 25.9 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EWC44630.1 - 0.0021 18.1 0.0 2.1 8.5 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC44630.1 - 0.02 15.3 0.0 0.031 14.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3246 PF11596.8 EWC44631.1 - 0.086 12.3 0.8 0.17 11.3 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Fungal_trans_2 PF11951.8 EWC44632.1 - 1.7e-63 214.7 0.0 2.1e-63 214.4 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44632.1 - 6.6e-08 32.5 7.5 1.1e-07 31.8 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tn7_Tnp_TnsA_C PF08721.11 EWC44632.1 - 0.11 13.2 0.0 0.31 11.7 0.0 1.8 2 0 0 2 2 2 0 TnsA endonuclease C terminal SAM_2 PF07647.17 EWC44633.1 - 2e-12 47.0 0.7 4.2e-12 46.0 0.7 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EWC44633.1 - 5e-10 39.7 2.1 5.7e-10 39.5 0.7 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 EWC44633.1 - 2.2e-06 28.1 0.2 5.3e-06 26.9 0.2 1.7 1 0 0 1 1 1 1 PH domain SAM_Ste50p PF09235.10 EWC44633.1 - 2.4e-05 24.5 0.1 6.5e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_PNT PF02198.16 EWC44633.1 - 0.0032 17.4 0.4 0.0062 16.5 0.4 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain MARVEL PF01284.23 EWC44634.1 - 0.00055 20.0 13.6 0.027 14.5 9.6 2.5 1 1 2 3 3 3 3 Membrane-associating domain DUF4149 PF13664.6 EWC44634.1 - 0.033 14.5 4.1 0.1 12.9 3.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) NPCC PF08058.11 EWC44634.1 - 0.075 13.1 0.1 0.68 10.0 0.1 2.2 2 0 0 2 2 2 0 Nuclear pore complex component CTV_P33 PF07184.11 EWC44634.1 - 0.078 12.0 0.0 0.48 9.4 0.0 1.9 2 0 0 2 2 2 0 Citrus tristeza virus P33 protein Ni_hydr_CYTB PF01292.20 EWC44634.1 - 0.11 12.1 5.4 0.037 13.6 2.6 1.6 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 TctB PF07331.11 EWC44634.1 - 0.54 10.5 10.4 0.059 13.6 5.9 1.6 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family CoA_binding_3 PF13727.6 EWC44634.1 - 5.6 6.9 8.1 1.8 8.6 3.8 2.1 1 1 1 2 2 2 0 CoA-binding domain DUF1640 PF07798.11 EWC44635.1 - 5.6e-56 189.3 10.4 6.5e-56 189.1 10.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HalX PF08663.10 EWC44635.1 - 0.0021 18.3 6.7 0.018 15.4 1.3 2.5 2 0 0 2 2 2 1 HalX domain MutS_II PF05188.17 EWC44635.1 - 0.042 14.1 2.6 0.1 12.9 2.6 1.6 1 1 0 1 1 1 0 MutS domain II HMMR_C PF15908.5 EWC44635.1 - 0.1 12.8 6.2 4.2 7.6 0.4 2.8 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor C-terminal Fungal_TACC PF12709.7 EWC44635.1 - 0.16 12.4 4.2 0.62 10.6 1.2 2.4 2 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Syntaxin_2 PF14523.6 EWC44635.1 - 0.22 11.9 7.2 3 8.3 1.1 2.5 1 1 1 2 2 2 0 Syntaxin-like protein DUF883 PF05957.13 EWC44635.1 - 0.45 11.2 5.4 0.37 11.4 0.9 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF5082 PF16888.5 EWC44635.1 - 0.51 10.6 9.3 0.098 12.9 1.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) GreA_GreB_N PF03449.15 EWC44635.1 - 0.78 9.9 5.7 2.5 8.3 5.7 1.9 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal OmpH PF03938.14 EWC44635.1 - 1.7 9.0 7.8 0.42 11.0 3.5 2.0 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) DOPA_dioxygen PF08883.11 EWC44636.1 - 5.2e-42 142.4 0.7 7.2e-42 141.9 0.7 1.2 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family PEX11 PF05648.14 EWC44637.1 - 3e-19 69.4 0.5 3.9e-14 52.7 0.3 2.6 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) 7tm_1 PF00001.21 EWC44637.1 - 0.057 12.7 0.0 0.062 12.6 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) G-patch PF01585.23 EWC44638.1 - 0.0016 18.3 0.1 0.0051 16.7 0.1 2.0 1 1 0 1 1 1 1 G-patch domain Borrelia_P83 PF05262.11 EWC44638.1 - 0.037 12.5 12.9 0.058 11.9 12.9 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF572 PF04502.13 EWC44638.1 - 0.044 13.4 15.2 0.059 13.0 15.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Nop53 PF07767.11 EWC44638.1 - 0.072 12.5 27.3 0.097 12.0 27.3 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Dsh_C PF12316.8 EWC44638.1 - 0.62 10.4 12.3 1.1 9.7 12.3 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Neur_chan_memb PF02932.16 EWC44638.1 - 0.95 9.5 3.3 1.2 9.1 3.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAPS PF04499.15 EWC44638.1 - 1.8 7.2 9.6 2.3 6.9 9.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 EWC44638.1 - 2.3 6.4 23.3 3.1 6.0 23.3 1.1 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 EWC44638.1 - 5 4.1 8.4 5.8 3.9 8.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Apt1 PF10351.9 EWC44638.1 - 5 5.9 11.8 6.7 5.5 11.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain PMM PF03332.13 EWC44639.1 - 2.1e-101 338.3 0.7 2.3e-101 338.2 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase cobW PF02492.19 EWC44640.1 - 1.2e-38 132.4 0.0 1.8e-38 131.9 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 EWC44640.1 - 0.032 14.0 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CobW_C PF07683.14 EWC44640.1 - 0.037 13.9 0.0 0.18 11.8 0.0 2.1 1 1 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.14 EWC44640.1 - 0.087 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 EWC44640.1 - 0.17 12.2 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain PARP_regulatory PF01358.18 EWC44640.1 - 0.2 10.5 0.0 0.29 10.0 0.0 1.1 1 0 0 1 1 1 0 Poly A polymerase regulatory subunit Ank_2 PF12796.7 EWC44641.1 - 9.3e-27 93.5 0.3 7.7e-07 29.6 0.0 6.3 3 1 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC44641.1 - 2.8e-25 88.4 0.4 2.9e-05 24.5 0.0 9.1 5 2 5 10 10 10 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EWC44641.1 - 6.8e-23 80.4 1.7 0.0024 18.1 0.0 8.6 7 1 1 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC44641.1 - 3.7e-15 54.5 1.4 11 7.0 0.0 11.0 11 0 0 11 11 11 1 Ankyrin repeat Ank PF00023.30 EWC44641.1 - 1.9e-14 53.3 6.0 0.02 15.3 0.1 9.5 10 0 0 10 10 10 3 Ankyrin repeat SPRY PF00622.28 EWC44641.1 - 1.6e-10 41.2 0.1 3.1e-10 40.2 0.1 1.5 1 0 0 1 1 1 1 SPRY domain NACHT PF05729.12 EWC44641.1 - 3.4e-06 27.1 0.0 1e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EWC44641.1 - 3.6e-06 27.5 0.0 1.6e-05 25.4 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain Borrelia_lipo_1 PF05714.11 EWC44641.1 - 8e-05 22.5 0.8 0.00023 21.0 0.8 1.7 1 0 0 1 1 1 1 Borrelia burgdorferi virulent strain associated lipoprotein AAA_22 PF13401.6 EWC44641.1 - 0.032 14.5 0.1 0.14 12.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain zf-H2C2 PF09337.10 EWC44642.1 - 0.47 10.7 11.7 0.88 9.8 0.2 3.3 3 0 0 3 3 3 0 H2C2 zinc finger Ank_2 PF12796.7 EWC44643.1 - 2.2e-58 194.8 12.0 6.3e-15 55.5 0.0 5.3 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC44643.1 - 1.6e-45 152.9 5.4 8.4e-12 45.4 0.0 6.6 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EWC44643.1 - 7.2e-41 136.9 9.4 7.8e-08 32.4 0.0 9.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 EWC44643.1 - 1.4e-36 120.4 10.5 5.5e-05 23.3 0.0 10.2 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 EWC44643.1 - 2.2e-30 104.3 14.8 1.9e-08 34.4 0.1 7.1 4 3 2 7 7 7 5 Ankyrin repeats (many copies) EPSP_synthase PF00275.20 EWC44643.1 - 0.086 11.5 0.4 13 4.3 0.0 2.6 2 1 0 3 3 3 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) EF-hand_4 PF12763.7 EWC44643.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF2390 PF09523.10 EWC44648.1 - 2.8 8.3 11.4 5.7 7.3 11.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2390) EVE PF01878.18 EWC44649.1 - 5.5e-48 162.7 0.0 6.2e-48 162.5 0.0 1.0 1 0 0 1 1 1 1 EVE domain DUF600 PF04634.12 EWC44649.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF600 bZIP_2 PF07716.15 EWC44650.1 - 0.00016 21.7 11.1 0.00029 20.9 11.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EWC44650.1 - 1.3 9.2 8.2 2.5 8.3 8.2 1.4 1 0 0 1 1 1 0 bZIP transcription factor Aldedh PF00171.22 EWC44651.1 - 8e-178 591.7 0.1 9.2e-178 591.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family TAXi_C PF14541.6 EWC44651.1 - 0.059 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal DUF1487 PF07368.11 EWC44651.1 - 0.15 11.5 0.0 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Aldedh PF00171.22 EWC44652.1 - 1.3e-164 548.1 0.2 1.5e-164 548.0 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Thioredoxin_4 PF13462.6 EWC44653.1 - 3.9e-05 23.9 0.0 0.00018 21.7 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin UvrD-helicase PF00580.21 EWC44654.1 - 1.4e-60 205.5 6.4 1.8e-60 205.1 1.4 2.8 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EWC44654.1 - 7.3e-58 196.6 0.0 2.2e-57 195.0 0.0 1.8 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EWC44654.1 - 1.5e-30 106.4 0.0 3.1e-30 105.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EWC44654.1 - 5.7e-14 51.7 0.0 1.3e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EWC44654.1 - 2.3e-07 30.7 0.0 1.8e-05 24.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EWC44654.1 - 7.5e-05 22.6 1.5 1.1 9.0 0.0 3.7 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EWC44654.1 - 0.00022 21.5 0.1 1.3 9.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 EWC44654.1 - 0.0015 18.4 0.2 0.0015 18.4 0.2 2.8 2 1 0 2 2 2 1 AAA domain Cyclin_N PF00134.23 EWC44655.1 - 1.5e-39 134.7 1.8 1.4e-38 131.5 0.2 2.4 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EWC44655.1 - 5.6e-11 42.6 1.9 1.9e-10 40.9 1.9 1.9 1 1 0 1 1 1 1 Cyclin, C-terminal domain DUF3306 PF11748.8 EWC44655.1 - 7.8 7.4 7.0 0.51 11.2 0.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3306) CBM_1 PF00734.18 EWC44656.1 - 4.1e-13 49.0 11.4 1.7e-12 47.1 11.4 2.2 1 0 0 1 1 1 1 Fungal cellulose binding domain Sortilin-Vps10 PF15902.5 EWC44656.1 - 2.1e-12 46.6 18.1 4.4e-05 22.5 0.0 5.9 4 2 1 6 6 6 5 Sortilin, neurotensin receptor 3, BNR_6 PF15899.5 EWC44656.1 - 2.3e-08 33.4 8.1 0.52 10.5 0.0 7.0 7 0 0 7 7 7 4 BNR-Asp box repeat BNR PF02012.20 EWC44656.1 - 6.4e-08 31.5 34.3 1.5 9.1 0.2 9.6 9 0 0 9 9 9 6 BNR/Asp-box repeat Glyco_hydro_18 PF00704.28 EWC44657.1 - 6.4e-19 68.8 0.0 8.3e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Gpr1_Fun34_YaaH PF01184.19 EWC44658.1 - 1.4e-83 279.6 14.7 1.6e-83 279.4 14.7 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family PIP5K PF01504.18 EWC44660.1 - 6e-37 127.4 0.5 7.5e-28 97.5 0.4 2.9 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EWC44660.1 - 2e-24 86.1 0.1 4.3e-24 85.0 0.1 1.4 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EWC44660.1 - 4.8e-15 55.5 11.8 1.3e-14 54.1 11.8 1.8 1 0 0 1 1 1 1 FYVE zinc finger Rad4 PF03835.15 EWC44660.1 - 0.048 13.3 0.1 0.21 11.2 0.1 2.1 1 0 0 1 1 1 0 Rad4 transglutaminase-like domain IBR PF01485.21 EWC44660.1 - 0.95 9.7 9.1 2.8 8.2 9.1 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain LSM PF01423.22 EWC44662.1 - 5.7e-10 38.8 0.0 6.9e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.7 EWC44662.1 - 0.0054 16.8 0.0 0.0067 16.5 0.0 1.1 1 0 0 1 1 1 1 Scd6-like Sm domain Ribosomal_S17_N PF16205.5 EWC44663.1 - 1.5e-33 114.9 0.3 2.8e-33 114.1 0.3 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EWC44663.1 - 9.2e-24 83.3 0.4 1.8e-23 82.4 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 tRNA_lig_CPD PF08302.11 EWC44663.1 - 0.1 12.0 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain Spc7 PF08317.11 EWC44664.1 - 8.4e-89 297.5 14.3 1.3e-88 296.9 14.3 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_N PF15402.6 EWC44664.1 - 4.4e-59 200.7 77.7 2.2e-33 115.6 23.2 5.1 2 1 3 5 5 5 4 N-terminus of kinetochore NMS complex subunit Spc7 Spc7_C2 PF15577.6 EWC44664.1 - 4.7e-08 33.0 0.0 8.1e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Spc7_C2 SUR7 PF06687.12 EWC44665.1 - 2.2e-32 112.4 13.9 2.6e-32 112.2 13.9 1.1 1 0 0 1 1 1 1 SUR7/PalI family GTP_EFTU PF00009.27 EWC44666.1 - 1e-58 198.1 1.5 1.3e-58 197.7 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EWC44666.1 - 3.9e-36 123.5 0.1 8.8e-36 122.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EWC44666.1 - 7.3e-33 112.5 0.0 2.2e-32 111.0 0.0 1.9 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_C PF00679.24 EWC44666.1 - 1.4e-21 76.3 0.1 1.2e-19 70.1 0.0 2.6 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EWC44666.1 - 2.4e-10 40.7 0.1 7.9e-10 39.0 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EWC44666.1 - 3.2e-07 30.2 0.1 1.8e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 EWC44666.1 - 0.031 14.8 0.0 0.27 11.7 0.0 2.3 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain DUF442 PF04273.13 EWC44666.1 - 0.12 12.4 0.0 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 Putative phosphatase (DUF442) Polysacc_synt_4 PF04669.13 EWC44667.1 - 1.2e-17 64.1 1.0 4.7e-16 58.9 1.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis Cor1 PF04803.12 EWC44667.1 - 0.01 16.1 0.4 0.016 15.4 0.4 1.4 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region PCRF PF03462.18 EWC44667.1 - 0.029 14.2 0.6 0.036 13.9 0.6 1.1 1 0 0 1 1 1 0 PCRF domain ABC_membrane PF00664.23 EWC44668.1 - 3.1e-81 273.0 22.1 4.1e-45 154.6 8.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EWC44668.1 - 1.6e-65 219.8 0.0 4.2e-32 111.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EWC44668.1 - 1.6e-09 37.5 0.0 0.0037 16.7 0.0 3.8 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EWC44668.1 - 4e-08 33.3 0.0 0.00054 19.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EWC44668.1 - 6.3e-08 33.2 0.1 0.0042 17.5 0.0 3.3 2 1 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EWC44668.1 - 8.1e-08 32.4 0.0 0.018 14.9 0.0 4.3 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EWC44668.1 - 5.6e-07 29.2 0.2 0.046 13.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EWC44668.1 - 2.4e-06 27.8 0.0 0.59 10.4 0.0 3.8 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EWC44668.1 - 4.5e-06 27.2 0.0 0.055 14.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EWC44668.1 - 2.5e-05 24.1 0.0 0.16 11.7 0.0 3.6 4 0 0 4 4 4 1 IstB-like ATP binding protein NACHT PF05729.12 EWC44668.1 - 0.00011 22.2 0.2 0.044 13.7 0.1 2.5 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 EWC44668.1 - 0.00017 21.8 0.4 0.58 10.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EWC44668.1 - 0.00021 21.4 0.5 0.33 11.0 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase APS_kinase PF01583.20 EWC44668.1 - 0.00047 20.1 0.1 1.4 8.8 0.0 2.6 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_24 PF13479.6 EWC44668.1 - 0.00073 19.3 0.2 0.9 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EWC44668.1 - 0.00097 19.5 0.1 0.19 12.1 0.0 2.9 3 0 0 3 3 2 1 RNA helicase AAA_25 PF13481.6 EWC44668.1 - 0.0011 18.6 0.0 2.4 7.7 0.0 3.0 3 0 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EWC44668.1 - 0.0014 17.8 0.3 1.2 8.3 0.1 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_23 PF13476.6 EWC44668.1 - 0.0017 18.9 0.0 2 8.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EWC44668.1 - 0.002 18.1 0.7 1.4 8.9 0.0 3.7 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EWC44668.1 - 0.0022 17.3 0.0 1.1 8.5 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin PRK PF00485.18 EWC44668.1 - 0.0022 17.8 0.0 0.97 9.1 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 EWC44668.1 - 0.0028 17.8 2.1 0.38 10.8 0.0 2.8 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_30 PF13604.6 EWC44668.1 - 0.0044 16.8 0.1 1.6 8.4 0.0 2.9 3 0 0 3 3 3 1 AAA domain ACR_tran PF00873.19 EWC44668.1 - 0.033 11.8 0.1 0.05 11.3 0.1 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Mg_chelatase PF01078.21 EWC44668.1 - 0.042 13.2 0.0 5.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EWC44668.1 - 0.045 14.0 0.5 12 6.1 0.1 2.7 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EWC44668.1 - 0.045 13.5 0.0 5.3 6.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain ATP-synt_ab PF00006.25 EWC44668.1 - 0.048 13.3 0.2 0.99 9.0 0.0 2.7 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase PF06745.13 EWC44668.1 - 0.073 12.4 0.3 15 4.9 0.0 2.5 2 0 0 2 2 2 0 KaiC Ploopntkinase3 PF18751.1 EWC44668.1 - 0.076 12.9 0.1 15 5.4 0.0 2.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_17 PF13207.6 EWC44668.1 - 0.084 13.3 0.0 4.8 7.6 0.0 3.1 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 EWC44668.1 - 0.096 12.4 0.0 4.9 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain CbiA PF01656.23 EWC44668.1 - 0.15 12.1 0.4 20 5.3 0.0 2.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain dNK PF01712.19 EWC44668.1 - 0.16 11.8 0.1 12 5.7 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase MobB PF03205.14 EWC44668.1 - 0.19 11.7 0.3 14 5.6 0.1 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.6 EWC44668.1 - 0.19 12.0 0.8 6 7.2 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TMEM154 PF15102.6 EWC44669.1 - 0.048 13.6 0.4 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family Adeno_E3_CR2 PF02439.15 EWC44669.1 - 7.4 6.4 7.1 13 5.6 7.1 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rad4 PF03835.15 EWC44670.1 - 4e-15 55.8 2.1 4.6e-15 55.6 0.6 1.9 2 1 0 2 2 2 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 EWC44670.1 - 7.3e-14 52.2 1.2 1.8e-13 50.9 1.2 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily HEPN_SAV_6107 PF18726.1 EWC44670.1 - 0.025 15.1 0.2 4.1 8.0 0.0 2.6 2 0 0 2 2 2 0 SAV_6107-like HEPN SPX PF03105.19 EWC44670.1 - 0.083 12.8 4.6 0.14 12.1 4.6 1.3 1 0 0 1 1 1 0 SPX domain Cupin_2 PF07883.11 EWC44671.1 - 1.4e-08 34.3 0.3 6.5e-08 32.2 0.0 2.0 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 EWC44671.1 - 0.15 11.8 0.1 0.29 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Peptidase_C14 PF00656.22 EWC44672.1 - 0.00039 20.4 0.1 0.0013 18.7 0.1 2.0 1 1 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 EWC44672.1 - 0.02 14.8 1.0 0.91 9.5 0.0 2.7 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain Pil1 PF13805.6 EWC44673.1 - 2.4e-127 423.9 0.1 3.4e-127 423.4 0.1 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 GP67 PF17634.2 EWC44673.1 - 0.91 10.0 0.1 0.91 10.0 0.1 2.6 2 0 0 2 2 2 0 Gene product 67 NOA36 PF06524.12 EWC44673.1 - 0.92 8.8 6.6 1.6 8.0 6.6 1.3 1 0 0 1 1 1 0 NOA36 protein Latarcin PF10279.9 EWC44673.1 - 5.4 7.5 7.6 0.85 10.1 1.7 2.6 3 0 0 3 3 3 0 Latarcin precursor MFS_1 PF07690.16 EWC44674.1 - 3.2e-47 161.2 46.3 3.2e-47 161.2 46.3 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC44674.1 - 2.1e-18 66.4 29.2 6.6e-17 61.5 8.9 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 EWC44674.1 - 1.6e-11 43.4 16.5 2.2e-11 42.9 16.5 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EWC44674.1 - 0.064 12.1 18.1 0.012 14.5 6.0 3.0 4 0 0 4 4 4 0 MFS_1 like family SHQ1 PF04925.15 EWC44674.1 - 0.087 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 SHQ1 protein OATP PF03137.20 EWC44674.1 - 0.74 8.0 17.8 6.4 4.9 15.8 2.5 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3425 PF11905.8 EWC44675.1 - 5.6e-15 55.4 3.0 1.3e-14 54.3 3.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EWC44675.1 - 0.0049 16.9 5.3 0.0089 16.1 5.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor Cep57_MT_bd PF06657.13 EWC44675.1 - 0.091 13.2 0.5 0.22 12.0 0.5 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 BMFP PF04380.13 EWC44675.1 - 0.095 13.2 1.1 0.95 10.0 0.4 2.3 2 0 0 2 2 2 0 Membrane fusogenic activity WD40 PF00400.32 EWC44677.1 - 2.1e-29 101.1 7.0 1.7e-06 28.6 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC44677.1 - 5e-12 46.0 0.1 0.0013 19.0 0.0 4.4 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC44677.1 - 0.027 13.1 0.6 0.8 8.3 0.0 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 EWC44677.1 - 0.088 11.8 0.0 0.31 10.0 0.0 1.8 1 1 0 1 1 1 0 Coatomer WD associated region WD40 PF00400.32 EWC44678.1 - 0.0049 17.7 8.1 55 4.9 0.0 8.3 10 1 0 10 10 10 0 WD domain, G-beta repeat PQQ PF01011.21 EWC44678.1 - 0.01 15.7 0.0 0.041 13.8 0.0 2.2 1 0 0 1 1 1 0 PQQ enzyme repeat Ge1_WD40 PF16529.5 EWC44678.1 - 0.014 14.4 0.0 0.1 11.6 0.1 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EWC44678.1 - 0.029 14.9 2.1 3.2 8.4 0.0 4.0 3 0 0 3 3 3 0 PQQ-like domain PD40 PF07676.12 EWC44678.1 - 0.041 13.8 0.1 10 6.2 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF1583 PF07622.11 EWC44679.1 - 0.14 10.9 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1583) OTT_1508_deam PF14441.6 EWC44679.1 - 0.29 11.2 5.3 0.16 12.0 1.6 2.3 2 1 0 2 2 2 0 OTT_1508-like deaminase DUF2142 PF09913.9 EWC44680.1 - 0.0088 14.9 0.4 0.012 14.5 0.4 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2142) DUF898 PF05987.13 EWC44680.1 - 0.011 14.8 0.3 0.013 14.6 0.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Iso_dh PF00180.20 EWC44681.1 - 4.1e-96 322.2 0.0 2.2e-95 319.8 0.0 1.8 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3586 PF12131.8 EWC44681.1 - 0.36 11.1 1.4 0.56 10.5 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3586) PigN PF04987.14 EWC44682.1 - 0.11 11.3 0.0 0.21 10.4 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Exonuc_VII_L PF02601.15 EWC44682.1 - 0.25 10.9 10.2 0.42 10.1 10.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Hid1 PF12722.7 EWC44682.1 - 0.3 9.1 13.1 0.43 8.6 13.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SDA1 PF05285.12 EWC44682.1 - 0.54 9.6 32.8 0.92 8.9 32.8 1.3 1 0 0 1 1 1 0 SDA1 BTB PF00651.31 EWC44683.1 - 7.4e-20 71.3 0.0 1.1e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 EWC44683.1 - 0.044 14.1 0.0 0.08 13.3 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain BTB PF00651.31 EWC44684.1 - 7.5e-15 55.1 0.0 1.5e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 EWC44685.1 - 1.1e-09 38.5 0.1 4.7e-09 36.5 0.1 2.0 1 1 0 1 1 1 1 BTB/POZ domain ATP-grasp_6 PF18419.1 EWC44685.1 - 1.2 8.8 3.0 0.77 9.4 0.1 2.2 3 0 0 3 3 3 0 ATP-grasp-like domain WD40 PF00400.32 EWC44686.1 - 1.1e-14 54.6 12.5 3.6e-05 24.4 0.1 8.5 9 0 0 9 9 9 4 WD domain, G-beta repeat XPG_N PF00752.17 EWC44687.1 - 4.3e-31 107.4 0.0 1.1e-30 106.0 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EWC44687.1 - 5.3e-26 90.8 0.0 2e-25 89.0 0.0 2.1 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EWC44687.1 - 0.0019 18.8 0.1 0.01 16.4 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold UIM PF02809.20 EWC44687.1 - 0.014 15.2 29.2 0.11 12.4 1.9 4.9 5 0 0 5 5 5 0 Ubiquitin interaction motif PUB_1 PF18486.1 EWC44687.1 - 0.048 13.5 0.1 0.15 12.0 0.1 1.8 1 0 0 1 1 1 0 PNGase/UBA- or UBX-containing domain NGP1NT PF08153.12 EWC44688.1 - 1.5e-49 167.5 3.6 2.5e-49 166.7 3.6 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EWC44688.1 - 2.7e-17 62.9 0.0 4.4e-14 52.6 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EWC44688.1 - 2e-05 24.2 0.0 6.5e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EWC44688.1 - 3.8e-05 23.8 0.5 0.22 11.6 0.0 3.6 2 2 1 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 EWC44688.1 - 0.003 17.5 0.0 0.0071 16.3 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EWC44688.1 - 0.0068 15.9 0.1 0.049 13.1 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EWC44688.1 - 0.031 13.8 0.0 6.7 6.2 0.0 3.1 2 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Peptidase_M35 PF02102.15 EWC44688.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family Cmc1 PF08583.10 EWC44690.1 - 3.2e-05 23.8 4.8 5.9e-05 23.0 4.8 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like FumaraseC_C PF10415.9 EWC44690.1 - 0.065 13.7 0.2 3.2 8.3 0.1 2.3 2 0 0 2 2 2 0 Fumarase C C-terminus DUF848 PF05852.11 EWC44691.1 - 5 7.2 14.2 0.021 14.9 4.6 2.0 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Fungal_trans_2 PF11951.8 EWC44692.1 - 1.7e-51 175.2 0.2 5.4e-27 94.6 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44692.1 - 4.4e-08 33.1 6.4 9.4e-08 32.1 6.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3835 PF12927.7 EWC44693.1 - 6.5e-27 94.2 0.3 6.5e-27 94.2 0.3 4.9 4 1 0 4 4 4 1 Domain of unknown function (DUF3835) Prefoldin_3 PF13758.6 EWC44693.1 - 3.3e-26 91.2 2.0 5.4e-26 90.6 0.1 2.4 2 0 0 2 2 2 1 Prefoldin subunit CDC45 PF02724.14 EWC44693.1 - 0.025 12.9 13.8 0.044 12.1 13.8 1.3 1 0 0 1 1 1 0 CDC45-like protein FAA_hydro_N_2 PF18288.1 EWC44693.1 - 1.3 9.5 3.5 5.6 7.5 0.2 3.1 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 CCDC-167 PF15188.6 EWC44693.1 - 5 7.5 10.5 7.4 7.0 0.5 3.7 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 SPT16 PF08644.11 EWC44693.1 - 5.1 7.3 10.8 0.085 13.0 1.8 2.7 3 0 0 3 3 3 0 FACT complex subunit (SPT16/CDC68) MAT1 PF06391.13 EWC44694.1 - 2.7e-53 180.9 27.9 3.4e-53 180.5 27.9 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EWC44694.1 - 1.1e-31 108.5 8.8 1.8e-31 107.8 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EWC44694.1 - 0.00025 20.8 4.8 0.00065 19.5 4.8 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC44694.1 - 0.00038 20.3 4.1 0.0011 18.8 4.2 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC44694.1 - 0.0006 19.6 5.6 0.001 18.9 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EWC44694.1 - 0.002 17.7 2.6 0.0045 16.6 2.6 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EWC44694.1 - 0.0029 17.5 7.4 0.017 15.1 7.9 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EWC44694.1 - 0.0042 17.4 6.7 0.0087 16.4 6.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EWC44694.1 - 0.068 13.2 6.9 0.14 12.2 6.9 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.6 EWC44694.1 - 0.13 12.0 5.6 1.2 9.0 2.3 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF3797 PF12677.7 EWC44694.1 - 0.24 11.3 5.9 0.56 10.1 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) US30 PF17624.2 EWC44694.1 - 0.39 9.7 2.0 0.67 9.0 2.0 1.3 1 0 0 1 1 1 0 Family of unknown function Prok-RING_4 PF14447.6 EWC44694.1 - 4.9 7.1 9.1 56 3.7 9.5 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Mur_ligase_M PF08245.12 EWC44695.1 - 6.5e-08 32.8 0.7 4.3e-06 26.8 0.7 3.1 1 1 0 1 1 1 1 Mur ligase middle domain PIN_12 PF16289.5 EWC44697.1 - 1.6 9.2 5.5 0.31 11.5 0.5 2.2 2 0 0 2 2 2 0 PIN domain TFX_C PF14601.6 EWC44699.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term PfkB PF00294.24 EWC44700.1 - 8e-15 54.9 1.7 3.2e-10 39.8 2.9 2.4 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Mersacidin PF16934.5 EWC44700.1 - 0.071 12.9 0.7 2.2 8.1 0.0 2.6 2 1 0 2 2 2 0 Two-component Enterococcus faecalis cytolysin (EFC) MTS PF05175.14 EWC44701.1 - 7.9e-05 22.3 0.0 0.00026 20.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Inositol_P PF00459.25 EWC44702.1 - 5.9e-66 222.8 0.0 6.6e-66 222.6 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FMO-like PF00743.19 EWC44703.1 - 2.2e-18 66.0 0.0 1.9e-16 59.6 0.0 2.0 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EWC44703.1 - 8.4e-13 48.2 0.0 5.6e-12 45.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC44703.1 - 3e-11 43.5 0.2 1e-09 38.5 0.0 3.2 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EWC44703.1 - 1.6e-09 37.9 2.1 2e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EWC44703.1 - 8.7e-08 31.7 0.1 1.9e-06 27.3 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EWC44703.1 - 2.1e-06 27.2 0.2 0.018 14.3 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC44703.1 - 2.4e-06 27.4 0.1 0.0028 17.3 0.1 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EWC44703.1 - 4.1e-05 23.1 0.0 0.00025 20.5 0.0 2.0 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 EWC44703.1 - 0.00012 21.4 0.0 0.0002 20.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EWC44703.1 - 0.009 16.6 0.7 6.8 7.3 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EWC44703.1 - 0.0098 14.6 0.2 0.016 13.9 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EWC44703.1 - 0.013 14.8 0.2 0.024 13.9 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain AAA PF00004.29 EWC44705.1 - 8.5e-79 262.4 0.0 5.2e-39 133.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC44705.1 - 2e-22 78.7 0.1 2.9e-15 55.8 0.1 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 EWC44705.1 - 8.4e-11 42.3 0.0 2.6e-06 27.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EWC44705.1 - 1.3e-10 41.3 0.0 0.0034 17.2 0.0 3.8 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EWC44705.1 - 6.3e-10 39.7 1.1 0.00013 22.4 0.1 3.8 2 2 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EWC44705.1 - 3e-09 37.0 0.4 0.0011 19.0 0.2 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EWC44705.1 - 1.2e-07 32.1 0.3 0.002 18.4 0.0 3.9 2 2 0 2 2 2 2 AAA domain Rad17 PF03215.15 EWC44705.1 - 4.2e-06 26.8 0.0 0.00054 19.9 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EWC44705.1 - 1.5e-05 24.5 0.7 0.1 11.9 0.1 3.1 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EWC44705.1 - 1.5e-05 25.0 0.0 0.015 15.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EWC44705.1 - 4.6e-05 23.6 0.0 0.19 11.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 EWC44705.1 - 5.3e-05 22.9 0.0 0.00011 21.9 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 RNA_helicase PF00910.22 EWC44705.1 - 9.8e-05 22.7 0.0 0.33 11.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 EWC44705.1 - 0.00016 21.7 0.0 0.14 12.2 0.0 2.8 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EWC44705.1 - 0.00017 21.4 0.0 0.19 11.4 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase_2 PF01637.18 EWC44705.1 - 0.00048 20.1 0.0 0.3 10.9 0.0 3.3 2 2 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EWC44705.1 - 0.00054 19.7 0.0 0.02 14.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EWC44705.1 - 0.00068 19.6 1.7 0.0077 16.2 0.0 3.1 4 0 0 4 4 3 1 NACHT domain AAA_7 PF12775.7 EWC44705.1 - 0.00077 19.0 0.1 0.22 11.0 0.0 2.7 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 EWC44705.1 - 0.001 19.4 0.1 0.61 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EWC44705.1 - 0.0012 18.1 0.0 0.63 9.2 0.0 2.5 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_30 PF13604.6 EWC44705.1 - 0.0029 17.4 0.3 0.42 10.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_3 PF07726.11 EWC44705.1 - 0.0059 16.5 0.0 4 7.3 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EWC44705.1 - 0.0069 16.2 0.0 0.99 9.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EWC44705.1 - 0.0085 16.6 0.0 0.39 11.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EWC44705.1 - 0.012 15.2 1.7 0.4 10.2 0.1 2.8 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 EWC44705.1 - 0.013 14.7 0.0 3.1 6.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EWC44705.1 - 0.02 14.6 0.0 0.4 10.4 0.0 2.9 3 1 0 3 3 3 0 Sigma-54 interaction domain Bac_DnaA PF00308.18 EWC44705.1 - 0.029 14.2 0.0 0.3 10.9 0.0 2.5 3 1 0 3 3 2 0 Bacterial dnaA protein ATPase PF06745.13 EWC44705.1 - 0.041 13.2 0.1 27 4.0 0.1 3.2 2 1 1 3 3 3 0 KaiC AAA_19 PF13245.6 EWC44705.1 - 0.061 13.7 0.9 0.86 9.9 0.1 2.6 2 1 0 2 2 2 0 AAA domain Vps4_C PF09336.10 EWC44705.1 - 0.1 12.6 0.1 9 6.4 0.0 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain AAA_17 PF13207.6 EWC44705.1 - 0.12 12.8 0.0 11 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 EWC44705.1 - 0.13 11.4 0.0 0.35 9.9 0.0 1.7 1 1 0 1 1 1 0 MCM P-loop domain KAP_NTPase PF07693.14 EWC44705.1 - 0.13 11.5 0.0 0.31 10.3 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain Sigma54_activ_2 PF14532.6 EWC44705.1 - 0.15 12.2 0.0 16 5.6 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EWC44705.1 - 0.17 10.9 0.1 3.2 6.7 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EWC44705.1 - 0.18 11.1 0.0 2.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Actin PF00022.19 EWC44706.1 - 1.5e-16 60.1 0.0 5.6e-16 58.1 0.0 1.9 2 0 0 2 2 2 1 Actin FtsA PF14450.6 EWC44706.1 - 0.0014 19.0 0.1 0.0036 17.7 0.1 1.8 1 1 0 1 1 1 1 Cell division protein FtsA MreB_Mbl PF06723.13 EWC44706.1 - 0.0021 16.9 0.0 0.014 14.3 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein Zip PF02535.22 EWC44706.1 - 6.5 5.9 5.1 5.1 6.2 2.0 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter DUF148 PF02520.17 EWC44707.1 - 0.076 13.1 1.2 7.1 6.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF3439 PF11921.8 EWC44708.1 - 3.8 7.5 18.2 1.1 9.2 6.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Per1 PF04080.13 EWC44709.1 - 0.014 15.2 0.4 0.015 15.1 0.4 1.1 1 0 0 1 1 1 0 Per1-like family DUF4604 PF15377.6 EWC44710.1 - 7.1 7.0 14.2 3.7 7.9 11.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4604) Lactonase PF10282.9 EWC44711.1 - 5.6e-59 200.1 0.0 8.6e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller COG5 PF10392.9 EWC44711.1 - 0.12 12.6 0.8 0.31 11.2 0.8 1.7 1 0 0 1 1 1 0 Golgi transport complex subunit 5 PDCD2_C PF04194.13 EWC44711.1 - 2 8.4 10.3 7.1 6.7 10.3 2.0 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain RR_TM4-6 PF06459.12 EWC44711.1 - 4.3 7.1 22.3 12 5.6 22.3 1.8 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EWC44711.1 - 8.5 5.0 16.9 13 4.4 16.9 1.2 1 0 0 1 1 1 0 Presenilin Red1 PF07964.11 EWC44711.1 - 8.9 4.4 21.1 14 3.7 21.1 1.2 1 0 0 1 1 1 0 Rec10 / Red1 MSA-2c PF12238.8 EWC44714.1 - 2 8.4 7.0 1.9 8.5 7.0 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF1729 PF08354.10 EWC44715.1 - 6.2e-158 525.3 0.0 1.1e-157 524.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EWC44715.1 - 7.2e-89 298.4 0.0 2.6e-88 296.6 0.0 2.0 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 EWC44715.1 - 4.3e-49 166.1 0.0 9.6e-49 165.0 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 EWC44715.1 - 3.2e-38 131.8 0.0 9.4e-38 130.3 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 EWC44715.1 - 4.1e-38 130.3 0.0 9.3e-38 129.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydratas PF01575.19 EWC44715.1 - 1.3e-37 128.1 0.1 3.4e-37 126.8 0.1 1.8 1 0 0 1 1 1 1 MaoC like domain FA_hydroxylase PF04116.13 EWC44715.1 - 3.7e-25 88.8 20.0 9.9e-25 87.4 20.0 1.8 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily MaoC_dehydrat_N PF13452.6 EWC44715.1 - 7e-20 71.5 0.0 2.2e-19 69.9 0.0 1.9 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Fas_alpha_ACP PF18325.1 EWC44716.1 - 4.8e-76 254.6 0.0 1.7e-75 252.8 0.0 2.0 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 EWC44716.1 - 2e-75 252.9 0.0 4.2e-75 251.8 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 EWC44716.1 - 1.9e-18 67.0 0.0 3.9e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EWC44716.1 - 1.6e-15 57.2 0.0 4e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EWC44716.1 - 2.9e-13 49.9 0.0 7.4e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 EWC44716.1 - 0.0056 16.6 0.0 0.018 15.0 0.0 1.8 1 0 0 1 1 1 1 KR domain TRM PF02005.16 EWC44717.1 - 5.3e-89 299.0 0.0 1.5e-88 297.6 0.0 1.6 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase SSP160 PF06933.11 EWC44717.1 - 0.046 11.9 14.8 0.088 11.0 14.8 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Met_10 PF02475.16 EWC44717.1 - 0.056 13.2 0.0 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 Met-10+ like-protein MTS PF05175.14 EWC44717.1 - 0.066 12.7 0.0 0.3 10.6 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase small domain TRM PF02005.16 EWC44718.1 - 5.7e-11 42.2 0.0 7.3e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DUF4554 PF15091.6 EWC44718.1 - 0.37 9.6 3.0 0.49 9.2 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) DEAD PF00270.29 EWC44720.1 - 1.1e-12 48.1 0.0 2e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC44720.1 - 6.1e-06 26.5 0.0 4.6e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_25 PF13481.6 EWC44720.1 - 0.036 13.7 0.0 0.086 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EWC44720.1 - 0.11 12.9 0.4 1.8 9.0 0.4 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EWC44720.1 - 0.17 11.3 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 EWC44720.1 - 0.18 11.3 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region YabA PF06156.13 EWC44720.1 - 0.2 12.3 0.2 1.3 9.7 0.0 2.3 2 0 0 2 2 2 0 Initiation control protein YabA DUF1180 PF06679.12 EWC44721.1 - 2.4 8.6 5.1 2.6 8.5 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2985 PF11204.8 EWC44722.1 - 1.4e-21 76.4 3.9 2.8e-21 75.5 3.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Glyoxalase PF00903.25 EWC44723.1 - 3.3e-09 37.0 0.0 2.4e-08 34.2 0.0 2.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EWC44723.1 - 0.0016 18.7 0.0 0.0034 17.7 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily NmrA PF05368.13 EWC44725.1 - 3.4e-18 66.1 0.0 5.1e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EWC44725.1 - 1.5e-05 24.9 0.0 3e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EWC44725.1 - 0.05 13.1 0.1 0.27 10.7 0.0 2.1 3 0 0 3 3 3 0 NAD dependent epimerase/dehydratase family Pribosyltran_N PF13793.6 EWC44726.1 - 1.5e-39 134.5 0.0 4.9e-38 129.6 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EWC44726.1 - 1e-33 117.0 0.3 1.1e-24 87.5 0.1 2.2 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EWC44726.1 - 1e-08 34.8 0.1 2e-06 27.4 0.1 2.4 2 0 0 2 2 2 2 Phosphoribosyl transferase domain DUF2300 PF10062.9 EWC44726.1 - 0.058 13.5 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 Predicted secreted protein (DUF2300) Ala_racemase_N PF01168.20 EWC44727.1 - 2.3e-20 73.2 0.2 4.1e-20 72.4 0.2 1.5 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain TetR_C_11 PF16859.5 EWC44727.1 - 0.034 14.5 2.4 0.078 13.3 0.8 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Macro_2 PF14519.6 EWC44727.1 - 0.19 11.0 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Macro-like domain Actin PF00022.19 EWC44728.1 - 3.7e-48 164.1 0.0 1.6e-29 102.8 0.0 2.3 2 0 0 2 2 2 2 Actin DASH_Dad4 PF08650.10 EWC44729.1 - 6e-28 96.6 3.2 6.5e-28 96.5 3.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DUF4315 PF14193.6 EWC44729.1 - 0.013 15.5 0.1 0.022 14.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) DASH_Dad1 PF08649.10 EWC44729.1 - 0.034 14.3 2.1 0.034 14.3 2.1 1.4 1 1 1 2 2 2 0 DASH complex subunit Dad1 zf-C2H2 PF00096.26 EWC44730.1 - 0.00031 21.0 26.6 0.27 11.8 0.1 5.2 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC44730.1 - 0.05 14.5 23.9 1.7 9.7 0.0 5.7 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EWC44730.1 - 0.13 12.3 5.8 0.44 10.6 0.0 3.6 4 0 0 4 4 4 0 C2H2-type zinc finger RNA_POL_M_15KD PF02150.16 EWC44730.1 - 2.1 8.3 7.9 15 5.6 0.2 3.7 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit zf-C2H2_jaz PF12171.8 EWC44730.1 - 3.6 8.0 10.3 7.5 7.0 0.0 3.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding His_Phos_2 PF00328.22 EWC44731.1 - 3.8e-103 345.8 0.0 5.3e-103 345.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EWC44731.1 - 9.4e-37 125.1 0.0 2e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EWC44731.1 - 0.0013 18.4 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Utp21 PF04192.12 EWC44732.1 - 1.2e-77 260.5 0.1 1.8e-77 260.0 0.1 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EWC44732.1 - 1.3e-17 63.8 23.2 7.6e-06 26.6 0.6 9.3 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC44732.1 - 7.7e-16 58.2 0.0 0.0067 16.7 0.0 7.3 3 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EWC44732.1 - 0.015 15.6 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family Ge1_WD40 PF16529.5 EWC44732.1 - 0.018 14.0 0.1 4 6.3 0.0 3.5 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HPS3_N PF14761.6 EWC44732.1 - 0.022 14.3 0.0 0.06 12.9 0.0 1.7 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 eIF2A PF08662.11 EWC44732.1 - 0.07 13.0 0.0 0.49 10.3 0.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EWC44732.1 - 0.18 10.4 0.4 11 4.5 0.0 3.0 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Ras PF00071.22 EWC44734.1 - 1.7e-65 219.6 0.0 2e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC44734.1 - 3.4e-34 117.6 0.1 5.2e-34 117.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC44734.1 - 4.8e-13 48.9 0.1 5.8e-13 48.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EWC44734.1 - 2.6e-06 27.1 0.5 2e-05 24.2 0.1 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EWC44734.1 - 0.00014 21.3 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EWC44734.1 - 0.0032 17.5 0.0 0.0054 16.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EWC44734.1 - 0.0082 16.1 0.1 2.7 7.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EWC44734.1 - 0.075 12.6 0.0 0.31 10.6 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Homeodomain PF00046.29 EWC44734.1 - 0.27 11.1 1.5 25 4.8 2.1 2.4 2 0 0 2 2 2 0 Homeodomain AAA PF00004.29 EWC44735.1 - 3.7e-44 150.3 0.1 1.3e-42 145.3 0.0 3.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC44735.1 - 2.7e-15 55.9 0.1 1.4e-14 53.6 0.1 2.4 1 0 0 1 1 1 1 AAA+ lid domain GRIP PF01465.20 EWC44735.1 - 1.3e-13 50.6 0.4 3e-13 49.4 0.4 1.7 1 0 0 1 1 1 1 GRIP domain AAA_5 PF07728.14 EWC44735.1 - 3.8e-07 30.2 0.1 2.5e-06 27.5 0.0 2.6 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EWC44735.1 - 0.00019 21.2 0.0 0.00084 19.1 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EWC44735.1 - 0.0002 21.5 2.7 0.019 15.1 0.0 4.2 3 0 0 3 3 3 1 AAA domain Prot_ATP_ID_OB PF16450.5 EWC44735.1 - 0.0003 20.7 0.8 0.00066 19.6 0.8 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EWC44735.1 - 0.00059 20.3 0.1 0.00059 20.3 0.1 5.2 4 3 1 5 5 3 1 AAA ATPase domain IstB_IS21 PF01695.17 EWC44735.1 - 0.0097 15.7 0.0 0.03 14.0 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EWC44735.1 - 0.017 15.0 0.0 0.06 13.2 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EWC44735.1 - 0.03 13.7 0.1 0.095 12.1 0.1 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EWC44735.1 - 0.042 14.1 0.2 0.042 14.1 0.2 4.8 3 2 0 4 4 4 0 AAA domain TsaE PF02367.17 EWC44735.1 - 0.045 13.7 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EWC44735.1 - 0.13 12.9 0.0 0.13 12.9 0.0 5.7 5 2 0 5 5 4 0 AAA domain RNA_helicase PF00910.22 EWC44735.1 - 0.14 12.6 0.0 0.42 11.0 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Spc7 PF08317.11 EWC44735.1 - 0.33 9.8 177.7 0.013 14.4 14.0 10.7 4 2 7 11 11 11 0 Spc7 kinetochore protein ERM PF00769.19 EWC44735.1 - 0.46 10.3 205.2 0.19 11.5 26.0 9.3 3 2 5 8 8 6 0 Ezrin/radixin/moesin family AAA_14 PF13173.6 EWC44735.1 - 0.5 10.4 0.0 0.5 10.4 0.0 3.9 4 0 0 4 4 4 0 AAA domain Glyco_hydro_7 PF00840.20 EWC44736.1 - 7.6e-111 370.9 14.8 3.9e-109 365.3 14.8 2.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 7 DUF1887 PF09002.11 EWC44737.1 - 0.098 11.3 0.2 0.16 10.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) NmrA PF05368.13 EWC44738.1 - 3.4e-25 89.0 0.0 4e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EWC44738.1 - 1.4e-15 57.7 0.2 5.3e-15 55.8 0.0 1.8 1 1 1 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EWC44738.1 - 0.019 15.4 0.0 0.041 14.3 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GCIP PF13324.6 EWC44739.1 - 1.2e-18 67.7 3.8 4.4e-17 62.5 3.8 2.3 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting Acetyltransf_3 PF13302.7 EWC44740.1 - 1.6e-08 35.3 0.0 2.5e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MS_channel PF00924.18 EWC44741.1 - 6.6e-23 81.3 1.0 1.2e-22 80.5 1.0 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 EWC44741.1 - 0.0035 16.8 0.2 0.0094 15.4 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EWC44741.1 - 0.0048 16.7 0.0 0.018 14.9 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain Nic96 PF04097.14 EWC44742.1 - 9.1e-208 691.7 0.0 1.1e-207 691.4 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 NTR2 PF15458.6 EWC44742.1 - 0.0093 15.5 0.1 0.02 14.5 0.1 1.5 1 0 0 1 1 1 1 Nineteen complex-related protein 2 Anoctamin PF04547.12 EWC44744.1 - 8.5e-116 387.4 11.1 1e-115 387.2 11.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Cation_efflux PF01545.21 EWC44745.1 - 1.6e-49 168.4 4.1 2.3e-49 167.8 4.1 1.2 1 0 0 1 1 1 1 Cation efflux family 7tm_7 PF08395.12 EWC44745.1 - 0.079 12.2 1.9 2 7.5 0.4 2.4 1 1 1 2 2 2 0 7tm Chemosensory receptor ZT_dimer PF16916.5 EWC44745.1 - 0.1 12.7 2.7 0.12 12.5 0.2 2.3 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter Pkinase PF00069.25 EWC44746.1 - 1.9e-43 148.7 0.0 7.8e-24 84.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC44746.1 - 2.5e-13 49.9 0.1 2e-09 37.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC44746.1 - 0.094 11.5 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Na_Ca_ex PF01699.24 EWC44747.1 - 7.1e-15 55.3 25.1 3e-09 37.0 8.0 4.2 6 0 0 6 6 6 2 Sodium/calcium exchanger protein YccF PF03733.13 EWC44747.1 - 8.9e-15 55.1 4.6 8.9e-15 55.1 4.6 4.4 5 0 0 5 5 5 1 Inner membrane component domain DUF1335 PF07056.11 EWC44747.1 - 0.031 14.4 0.3 0.07 13.2 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) DUF2070 PF09843.9 EWC44747.1 - 8.2 4.6 13.2 21 3.2 13.2 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) zinc_ribbon_10 PF10058.9 EWC44749.1 - 6.2e-21 73.9 0.3 1e-20 73.2 0.3 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein CCDC-167 PF15188.6 EWC44749.1 - 0.13 12.6 0.1 0.64 10.4 0.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Adaptin_N PF01602.20 EWC44750.1 - 6.9e-126 420.9 4.4 8.4e-126 420.6 4.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EWC44750.1 - 6.9e-45 151.9 0.0 1.6e-44 150.7 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EWC44750.1 - 2.7e-15 56.6 0.7 2.7e-15 56.6 0.7 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 EWC44750.1 - 0.0011 19.1 1.1 0.085 12.9 0.0 3.0 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EWC44750.1 - 0.014 15.5 0.4 0.077 13.2 0.2 2.3 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Dopey_N PF04118.14 EWC44750.1 - 0.093 11.8 0.4 0.28 10.2 0.1 2.0 3 0 0 3 3 3 0 Dopey, N-terminal bZIP_1 PF00170.21 EWC44751.1 - 4.2e-08 33.2 11.6 2e-07 31.0 11.6 2.0 1 1 0 1 1 1 1 bZIP transcription factor DUF2205 PF10224.9 EWC44751.1 - 0.025 14.6 3.9 0.048 13.7 3.9 1.4 1 0 0 1 1 1 0 Short coiled-coil protein bZIP_2 PF07716.15 EWC44751.1 - 0.16 12.1 17.6 0.13 12.4 2.1 2.6 1 1 1 2 2 2 0 Basic region leucine zipper Pannexin_like PF12534.8 EWC44751.1 - 1.6 7.8 6.9 1.7 7.6 0.9 2.0 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 UPF0242 PF06785.11 EWC44751.1 - 4.7 7.3 7.9 0.097 12.8 0.9 1.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SelP_N PF04592.14 EWC44751.1 - 9.9 5.5 19.5 1 8.7 14.7 1.7 2 0 0 2 2 2 0 Selenoprotein P, N terminal region NCA2 PF08637.10 EWC44752.1 - 1.5e-99 332.9 0.0 2.1e-99 332.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 DAO PF01266.24 EWC44753.1 - 1.3e-26 94.0 6.3 1e-25 91.1 6.3 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EWC44753.1 - 0.0009 19.4 0.1 0.0021 18.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EWC44753.1 - 0.052 12.8 0.0 0.091 12.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EWC44753.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase YL1_C PF08265.11 EWC44754.1 - 4.5e-15 55.1 0.3 7.9e-15 54.3 0.1 1.6 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain DUF1702 PF08012.11 EWC44754.1 - 0.17 10.7 0.8 0.23 10.3 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1702) Brr6_like_C_C PF10104.9 EWC44755.1 - 6e-47 158.8 2.7 7.5e-47 158.4 2.7 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain COX4_pro_2 PF07835.12 EWC44756.1 - 0.003 17.6 1.5 0.0048 17.0 1.5 1.3 1 0 0 1 1 1 1 Bacterial aa3 type cytochrome c oxidase subunit IV FeoB_associated PF12669.7 EWC44756.1 - 0.83 10.1 3.4 1.8 9.0 3.4 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Y_phosphatase PF00102.27 EWC44757.1 - 4.6e-64 216.2 1.8 1.9e-62 210.9 1.8 2.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 EWC44757.1 - 2.3e-09 37.7 0.0 1.2e-08 35.4 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 EWC44757.1 - 0.0068 16.2 0.5 0.015 15.1 0.2 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EWC44757.1 - 0.0099 15.9 0.2 0.026 14.5 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family DUF3376 PF11856.8 EWC44758.1 - 0.1 11.5 0.4 0.12 11.3 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3376) Vesiculo_matrix PF06326.12 EWC44759.1 - 0.18 11.5 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Vesiculovirus matrix protein COX16 PF14138.6 EWC44761.1 - 5.1e-31 107.0 0.1 7.5e-31 106.5 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 OppC_N PF12911.7 EWC44761.1 - 0.00064 19.6 0.0 0.00084 19.3 0.0 1.2 1 0 0 1 1 1 1 N-terminal TM domain of oligopeptide transport permease C Arc_PepC_II PF06847.11 EWC44761.1 - 0.17 12.4 1.2 2.9 8.5 0.0 2.1 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Pterin_4a PF01329.19 EWC44762.1 - 8.1e-07 29.1 0.0 2.6e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase FGGY_C PF02782.16 EWC44763.1 - 1.7e-49 168.3 0.4 2.4e-49 167.8 0.4 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EWC44763.1 - 9.1e-20 71.3 0.1 6.4e-17 61.9 0.0 2.4 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EWC44763.1 - 0.07 12.6 0.2 1.4 8.4 0.0 2.5 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family DEDD_Tnp_IS110 PF01548.17 EWC44763.1 - 0.16 11.9 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 Transposase REPA_OB_2 PF16900.5 EWC44764.1 - 7.5e-07 29.0 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Replication protein A OB domain Rep-A_N PF04057.12 EWC44764.1 - 0.033 14.2 0.0 0.085 12.9 0.0 1.7 1 1 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain BRCA-2_OB1 PF09103.10 EWC44764.1 - 0.2 11.6 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Cellulase PF00150.18 EWC44765.1 - 2.8e-20 72.9 0.2 5.3e-20 72.0 0.2 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ricin_B_lectin PF00652.22 EWC44765.1 - 2.3e-17 63.5 0.0 3.9e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EWC44765.1 - 2.8e-11 44.0 1.2 2.1e-06 28.4 0.2 3.6 4 0 0 4 4 4 2 Ricin-type beta-trefoil lectin domain-like Glyco_hydro_5_C PF18564.1 EWC44765.1 - 5e-07 30.2 0.1 1.2e-06 28.9 0.1 1.7 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_42 PF02449.15 EWC44765.1 - 2.6e-06 27.1 0.0 4.2e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 EWC44765.1 - 0.023 14.3 0.1 0.041 13.5 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 Glyco_hydro_1 PF00232.18 EWC44765.1 - 0.034 12.6 0.1 0.054 11.9 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 MFS_1 PF07690.16 EWC44770.1 - 1.8e-48 165.3 28.4 2.9e-48 164.6 28.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC44770.1 - 1.8e-14 53.5 6.3 1.8e-14 53.5 6.3 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EWC44770.1 - 1.2e-06 27.2 2.3 1.6e-06 26.9 2.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EWC44770.1 - 2.1e-06 27.3 6.6 2.1e-06 27.3 6.6 1.6 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB BT1 PF03092.16 EWC44770.1 - 0.0043 15.3 0.9 1.5 6.9 0.1 2.3 2 0 0 2 2 2 2 BT1 family GSK-3_bind PF05350.12 EWC44771.1 - 1.1 8.5 5.1 8.8 5.6 0.2 2.1 2 0 0 2 2 2 0 Glycogen synthase kinase-3 binding Maelstrom PF13017.6 EWC44773.1 - 0.0055 16.4 0.1 0.031 14.0 0.0 1.9 2 0 0 2 2 2 1 piRNA pathway germ-plasm component Myco_19_kDa PF05481.12 EWC44773.1 - 0.11 12.7 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen HA2 PF04408.23 EWC44774.1 - 1.4e-15 57.5 0.0 1.4e-15 57.5 0.0 2.6 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EWC44774.1 - 2.3e-13 50.5 0.0 1.1e-12 48.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EWC44774.1 - 3.3e-13 49.8 0.2 9.8e-13 48.2 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EWC44774.1 - 4.3e-08 33.5 0.5 1.8e-07 31.5 0.2 2.2 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EWC44774.1 - 0.0082 15.5 0.0 0.019 14.3 0.0 1.6 1 0 0 1 1 1 1 KaiC T2SSE PF00437.20 EWC44774.1 - 0.019 14.0 0.0 0.04 13.0 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EWC44774.1 - 0.065 13.7 0.2 0.63 10.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EWC44774.1 - 0.089 12.5 0.0 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EWC44774.1 - 0.1 12.5 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 EWC44774.1 - 0.17 12.4 0.0 0.7 10.4 0.0 2.1 1 0 0 1 1 1 0 ABC transporter DHquinase_I PF01487.15 EWC44775.1 - 1.8e-47 162.5 0.0 3.3e-47 161.7 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase AP_endonuc_2 PF01261.24 EWC44775.1 - 3.1e-33 115.0 0.0 3.4e-31 108.3 0.0 2.8 3 0 0 3 3 3 1 Xylose isomerase-like TIM barrel Glyoxalase_5 PF14696.6 EWC44775.1 - 1.1e-24 87.2 0.0 2.9e-24 85.8 0.0 1.7 1 0 0 1 1 1 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase PF00903.25 EWC44775.1 - 2.2e-07 31.1 0.0 0.0091 16.2 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EWC44775.1 - 0.00013 22.2 0.0 0.23 11.7 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Fungal_trans PF04082.18 EWC44776.1 - 1.1e-24 86.9 0.0 1.9e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44776.1 - 2.6e-05 24.3 19.2 6.5e-05 23.0 19.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HEPN_SAV_6107 PF18726.1 EWC44776.1 - 0.016 15.7 0.1 2.4 8.7 0.0 2.4 2 0 0 2 2 2 0 SAV_6107-like HEPN Flavin_Reduct PF01613.18 EWC44777.1 - 4.3e-10 39.8 0.0 5.2e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain MCU PF04678.13 EWC44778.1 - 6.2e-24 85.0 0.0 6.2e-24 85.0 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial calcium uniporter adh_short PF00106.25 EWC44779.1 - 0.0024 17.4 0.0 0.0045 16.5 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC44779.1 - 0.03 13.9 0.0 0.057 13.0 0.0 1.4 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Mg-por_mtran_C PF07109.11 EWC44779.1 - 0.054 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus NicO PF03824.16 EWC44780.1 - 0.2 10.9 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein PBP_sp32 PF07222.12 EWC44780.1 - 5.9 6.3 9.6 11 5.4 9.6 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 MFS_1 PF07690.16 EWC44781.1 - 5.6e-27 94.6 56.9 6.6e-25 87.8 33.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC44781.1 - 1.4e-06 27.4 7.1 1.4e-06 27.4 7.1 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EWC44781.1 - 0.022 13.2 3.4 0.13 10.6 1.3 2.2 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EWC44781.1 - 0.033 13.0 0.2 0.033 13.0 0.2 2.3 3 2 0 3 3 3 0 MFS_1 like family MFS_3 PF05977.13 EWC44781.1 - 0.54 8.6 8.5 0.016 13.6 1.3 1.8 2 0 0 2 2 2 0 Transmembrane secretion effector DnaJ PF00226.31 EWC44782.1 - 3.7e-23 81.4 1.3 1.3e-22 79.7 1.3 2.0 1 0 0 1 1 1 1 DnaJ domain NPR3 PF03666.13 EWC44782.1 - 0.19 10.5 5.7 0.29 9.9 5.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pep1_7 PF17232.2 EWC44782.1 - 4 8.0 7.5 0.47 11.0 1.7 2.4 3 0 0 3 3 3 0 Elicitor peptide 1-7 Presenilin PF01080.17 EWC44782.1 - 7.1 5.3 6.9 10 4.8 6.9 1.3 1 0 0 1 1 1 0 Presenilin MMR_HSR1 PF01926.23 EWC44783.1 - 1.2e-19 70.5 0.0 1.6e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EWC44783.1 - 1.1e-06 28.2 0.0 1.5e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 EWC44783.1 - 1.7e-05 24.3 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EWC44783.1 - 1.8e-05 24.4 0.0 0.00095 18.8 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EWC44783.1 - 5.3e-05 23.2 0.1 0.0042 17.0 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 EWC44783.1 - 0.00027 20.3 0.0 0.14 11.5 0.0 2.1 2 0 0 2 2 2 2 AIG1 family Dynamin_N PF00350.23 EWC44783.1 - 0.0013 18.8 0.1 0.033 14.2 0.1 2.2 1 1 1 2 2 2 1 Dynamin family FA_synthesis PF02504.15 EWC44783.1 - 0.0024 17.0 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 Fatty acid synthesis protein Roc PF08477.13 EWC44783.1 - 0.022 15.0 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 EWC44783.1 - 0.071 12.4 0.0 1.4 8.1 0.0 2.4 1 1 1 2 2 2 0 Septin IIGP PF05049.13 EWC44783.1 - 0.13 11.2 0.0 0.19 10.8 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Sec63 PF02889.16 EWC44784.1 - 1e-33 116.6 0.0 1.5e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EWC44784.1 - 1.9e-23 83.2 0.0 4.2e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EWC44784.1 - 2.2e-11 44.0 0.0 4.1e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EWC44784.1 - 1.2e-06 28.8 0.0 3.7e-06 27.3 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EWC44784.1 - 0.0029 17.3 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 EWC44784.1 - 0.017 14.7 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 EWC44784.1 - 0.065 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EWC44784.1 - 0.07 13.5 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain HHH_5 PF14520.6 EWC44784.1 - 0.082 13.5 0.5 0.31 11.7 0.0 2.2 3 0 0 3 3 3 0 Helix-hairpin-helix domain Na_Ca_ex PF01699.24 EWC44785.1 - 1.8e-41 141.6 41.3 2.8e-21 76.1 13.0 2.5 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Nuc_sug_transp PF04142.15 EWC44786.1 - 2.1e-116 388.5 13.8 2.5e-116 388.3 13.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EWC44786.1 - 2.8e-07 30.0 11.5 4.7e-07 29.3 11.4 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EWC44786.1 - 3.9e-05 23.8 1.3 3.9e-05 23.8 1.3 2.8 2 1 0 2 2 2 1 EamA-like transporter family PUNUT PF16913.5 EWC44786.1 - 0.00057 19.2 1.7 0.00057 19.2 1.7 2.8 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport EmrE PF13536.6 EWC44786.1 - 0.0021 17.7 0.7 0.0021 17.7 0.7 2.1 2 0 0 2 2 2 1 Putative multidrug resistance efflux transporter TPT PF03151.16 EWC44786.1 - 0.012 15.0 11.7 0.35 10.2 0.3 2.4 2 0 0 2 2 2 0 Triose-phosphate Transporter family TMEM234 PF10639.9 EWC44786.1 - 0.41 10.7 4.5 0.36 10.9 0.2 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 TPR_MLP1_2 PF07926.12 EWC44787.1 - 9.2e-33 113.1 22.8 9.2e-33 113.1 22.8 20.1 5 5 12 18 18 18 4 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 EWC44787.1 - 0.0046 17.2 4.5 0.0046 17.2 4.5 17.0 8 4 9 19 19 19 8 Fibrinogen alpha/beta chain family Methyltransf_11 PF08241.12 EWC44789.1 - 5.1e-19 68.7 0.0 1.5e-18 67.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC44789.1 - 1.8e-17 63.6 0.0 2.8e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44789.1 - 2.2e-15 57.1 0.0 3.6e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44789.1 - 9.7e-15 54.7 0.0 1.5e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC44789.1 - 7.7e-14 52.2 0.0 1.2e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EWC44789.1 - 2e-06 27.3 0.0 2.9e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EWC44789.1 - 6.3e-06 25.8 0.0 1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EWC44789.1 - 0.00023 20.6 0.0 0.00033 20.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EWC44789.1 - 0.0013 18.3 0.0 0.0022 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EWC44789.1 - 0.0055 16.7 0.0 0.0077 16.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EWC44789.1 - 0.0068 15.4 0.0 0.0099 14.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) FAM104 PF15434.6 EWC44789.1 - 0.1 13.2 0.2 0.16 12.5 0.2 1.2 1 0 0 1 1 1 0 Family 104 Methyltransf_24 PF13578.6 EWC44789.1 - 0.14 13.2 0.0 0.36 11.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 EWC44789.1 - 0.21 10.8 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain DUF3439 PF11921.8 EWC44789.1 - 3.1 7.8 6.9 5.6 6.9 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Velvet PF11754.8 EWC44790.1 - 2.1e-44 152.3 1.8 4.1e-31 108.8 0.2 4.0 2 2 1 3 3 3 2 Velvet factor MOZ_SAS PF01853.18 EWC44791.1 - 2.9e-74 248.6 0.0 4.4e-74 248.0 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EWC44791.1 - 7.6e-20 70.3 4.9 1.7e-19 69.2 4.9 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 EWC44791.1 - 4.6e-13 49.1 4.7 1.5e-12 47.4 4.7 1.9 1 0 0 1 1 1 1 PHD-finger PHD PF00628.29 EWC44791.1 - 6.1e-05 22.8 3.5 6.1e-05 22.8 3.5 2.2 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 EWC44791.1 - 0.038 13.9 0.4 0.038 13.9 0.4 2.5 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Acetyltransf_7 PF13508.7 EWC44791.1 - 0.059 13.8 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Prok-RING_1 PF14446.6 EWC44791.1 - 0.19 11.7 1.3 0.5 10.3 1.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Med3 PF11593.8 EWC44791.1 - 0.42 9.7 10.7 1 8.5 10.7 1.6 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PHD_Oberon PF07227.11 EWC44791.1 - 2 8.3 4.2 0.72 9.7 1.4 1.6 2 0 0 2 2 2 0 PHD - plant homeodomain finger protein Zf_RING PF16744.5 EWC44791.1 - 2.7 8.2 6.4 0.32 11.2 1.4 2.0 2 0 0 2 2 2 0 KIAA1045 RING finger Zn_ribbon_recom PF13408.6 EWC44791.1 - 3.3 8.3 5.1 0.56 10.8 1.0 1.9 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DNA_pol_phi PF04931.13 EWC44792.1 - 7.4 4.5 8.1 8.2 4.4 8.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi SAPS PF04499.15 EWC44793.1 - 6.7e-186 618.8 2.9 7.3e-185 615.4 0.0 2.4 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein Complex1_51K PF01512.17 EWC44794.1 - 3.1e-46 157.0 0.0 4.5e-46 156.5 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EWC44794.1 - 6.5e-29 99.8 1.4 1.3e-28 98.9 0.2 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EWC44794.1 - 4.5e-09 36.0 0.0 8.6e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 SLBB domain Snf7 PF03357.21 EWC44795.1 - 2.2e-44 151.1 15.9 2.5e-44 150.9 15.9 1.0 1 0 0 1 1 1 1 Snf7 CLZ PF16526.5 EWC44795.1 - 0.00087 19.6 3.8 0.049 14.0 0.0 3.2 2 1 1 3 3 3 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 EWC44795.1 - 0.0025 18.2 5.9 0.45 11.0 2.1 2.5 2 0 0 2 2 2 2 Nucleopolyhedrovirus P10 protein Prefoldin PF02996.17 EWC44795.1 - 0.0055 16.6 10.3 0.025 14.5 0.1 3.7 1 1 3 4 4 4 1 Prefoldin subunit Lebercilin PF15619.6 EWC44795.1 - 0.011 15.4 6.2 0.029 14.1 6.5 1.6 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF848 PF05852.11 EWC44795.1 - 0.011 15.8 3.6 0.011 15.8 3.6 2.2 1 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) MEIOC PF15189.6 EWC44795.1 - 0.017 14.7 6.3 0.012 15.2 4.6 1.5 1 1 1 2 2 2 0 Meiosis-specific coiled-coil domain-containing protein MEIOC DUF4094 PF13334.6 EWC44795.1 - 0.021 15.2 5.0 0.23 11.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) FlaC_arch PF05377.11 EWC44795.1 - 0.024 15.0 3.7 9.9 6.6 1.5 3.3 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) bZIP_1 PF00170.21 EWC44795.1 - 0.031 14.4 6.2 4.5 7.4 0.6 3.5 2 1 1 3 3 3 0 bZIP transcription factor FapA PF03961.13 EWC44795.1 - 0.064 11.8 8.7 0.34 9.5 8.8 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A ABC_tran_CTD PF16326.5 EWC44795.1 - 0.066 13.5 7.8 0.67 10.3 0.3 3.0 2 1 1 3 3 3 0 ABC transporter C-terminal domain ADIP PF11559.8 EWC44795.1 - 0.066 13.3 8.9 0.27 11.3 2.8 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.20 EWC44795.1 - 0.087 12.8 11.0 0.18 11.8 0.0 3.4 1 1 3 4 4 4 0 Prefoldin subunit YlqD PF11068.8 EWC44795.1 - 0.17 12.2 9.9 0.36 11.2 3.8 2.2 1 1 1 2 2 2 0 YlqD protein SlyX PF04102.12 EWC44795.1 - 0.17 12.5 8.0 0.18 12.4 0.3 3.4 1 1 2 3 3 3 0 SlyX DASH_Spc19 PF08287.11 EWC44795.1 - 0.18 11.7 6.0 0.86 9.5 5.9 2.0 1 1 0 1 1 1 0 Spc19 DUF2120 PF09893.9 EWC44795.1 - 0.21 11.7 2.8 0.55 10.3 2.4 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) DUF5082 PF16888.5 EWC44795.1 - 0.27 11.5 11.8 0.85 9.9 11.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Endotoxin_N PF03945.14 EWC44795.1 - 0.53 10.0 8.2 1.3 8.7 0.1 2.1 1 1 1 2 2 2 0 delta endotoxin, N-terminal domain DASH_Dam1 PF08653.10 EWC44795.1 - 1.9 8.4 6.9 23 4.9 0.1 3.6 3 1 1 4 4 4 0 DASH complex subunit Dam1 PRKG1_interact PF15898.5 EWC44795.1 - 5.6 7.9 11.5 5.8 7.9 9.3 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain FAM76 PF16046.5 EWC44795.1 - 7.9 5.7 11.2 22 4.3 10.9 1.8 1 1 0 1 1 1 0 FAM76 protein DUF1751 PF08551.10 EWC44796.1 - 0.032 14.8 1.3 0.044 14.3 0.2 1.7 1 1 1 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) Gly-zipper_Omp PF13488.6 EWC44796.1 - 0.066 13.2 0.3 0.13 12.3 0.3 1.4 1 0 0 1 1 1 0 Glycine zipper DUF1304 PF06993.12 EWC44796.1 - 0.13 12.3 1.8 0.28 11.2 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1304) RraA-like PF03737.15 EWC44797.1 - 4.6e-25 88.5 0.2 5.7e-25 88.2 0.2 1.1 1 0 0 1 1 1 1 Aldolase/RraA WD40 PF00400.32 EWC44798.1 - 1.1e-32 111.6 14.6 1.2e-05 26.0 0.2 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EWC44798.1 - 8.4e-13 48.0 0.2 1.8e-12 47.0 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC44798.1 - 1.7e-09 37.3 0.1 3.4e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EWC44798.1 - 0.0037 17.5 0.5 9.9 6.5 0.0 3.7 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC44798.1 - 0.064 11.9 1.3 2.6 6.6 0.5 3.4 3 1 1 4 4 4 0 Nucleoporin Nup120/160 WD40_like PF17005.5 EWC44798.1 - 0.09 12.1 0.0 0.66 9.2 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain Kelch_5 PF13854.6 EWC44800.1 - 2.1e-18 65.9 0.4 1.9e-10 40.5 0.2 3.9 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EWC44800.1 - 2.3e-10 40.4 7.1 0.012 15.9 0.1 5.6 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EWC44800.1 - 6.1e-09 35.5 5.7 0.092 12.8 0.1 5.6 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EWC44800.1 - 1.3e-07 31.5 1.6 0.0046 16.9 0.0 4.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EWC44800.1 - 0.00053 19.5 9.9 1.9 8.1 0.4 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EWC44800.1 - 0.0017 18.6 10.0 1.8 8.9 0.2 5.0 4 1 0 4 4 4 2 Galactose oxidase, central domain Insulin_TMD PF17870.1 EWC44800.1 - 0.017 15.2 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Abhydrolase_2 PF02230.16 EWC44801.1 - 2.3e-29 102.8 0.0 1.4e-21 77.3 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EWC44801.1 - 0.00054 19.5 0.0 0.00099 18.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family TFIIA PF03153.13 EWC44801.1 - 0.041 13.9 7.8 0.055 13.5 7.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 EWC44801.1 - 0.14 11.7 2.6 0.2 11.2 2.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TFIIF_alpha PF05793.12 EWC44801.1 - 0.2 10.2 12.4 0.28 9.7 12.4 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF5523 PF17661.1 EWC44801.1 - 0.77 9.4 10.0 1.2 8.8 10.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Nop14 PF04147.12 EWC44801.1 - 2.2 6.4 22.0 3 6.0 22.0 1.1 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 EWC44801.1 - 2.9 7.9 8.3 5.1 7.1 8.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal BUD22 PF09073.10 EWC44801.1 - 3.9 6.7 16.4 4.9 6.4 16.4 1.1 1 0 0 1 1 1 0 BUD22 DUF2722 PF10846.8 EWC44801.1 - 4.6 6.1 10.3 6.2 5.6 10.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CDC45 PF02724.14 EWC44801.1 - 8.7 4.5 15.9 13 4.0 15.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Brr6_like_C_C PF10104.9 EWC44802.1 - 0.0032 17.2 9.0 0.014 15.2 0.3 2.2 2 0 0 2 2 2 2 Di-sulfide bridge nucleocytoplasmic transport domain Sporozoite_P67 PF05642.11 EWC44802.1 - 0.23 9.5 3.0 0.3 9.1 3.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AA_permease_2 PF13520.6 EWC44803.1 - 1.1e-60 205.7 44.6 1.4e-60 205.3 44.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC44803.1 - 3.4e-19 68.8 40.9 1e-17 63.9 40.9 2.1 1 1 0 1 1 1 1 Amino acid permease GAS2 PF02187.17 EWC44804.1 - 1.4e-06 28.3 0.0 4.8e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain F-box-like PF12937.7 EWC44805.1 - 6.6e-09 35.5 1.1 1.5e-08 34.3 1.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC44805.1 - 0.0011 18.7 0.3 0.0047 16.8 0.3 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EWC44806.1 - 7.8e-07 28.9 0.0 3e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 F-box-like PhoLip_ATPase_C PF16212.5 EWC44807.1 - 2.3e-51 175.0 7.1 2.3e-51 175.0 7.1 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EWC44807.1 - 5.2e-15 54.9 1.4 1.1e-14 53.8 1.4 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EWC44807.1 - 1.8e-09 37.4 0.1 5.5e-09 35.8 0.1 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EWC44807.1 - 3e-09 37.5 3.3 1.6e-05 25.3 0.8 3.2 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EWC44807.1 - 9.8e-05 22.4 0.1 0.0038 17.3 0.0 3.2 4 1 0 4 4 4 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EWC44807.1 - 0.0074 16.1 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HIGH_NTase1_ass PF16581.5 EWC44807.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region Chal_sti_synt_C PF02797.15 EWC44813.1 - 0.04 13.9 0.0 2 8.4 0.0 2.2 2 0 0 2 2 2 0 Chalcone and stilbene synthases, C-terminal domain bMG3 PF11974.8 EWC44815.1 - 0.0011 19.0 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial alpha-2-macroglobulin MG3 domain UME PF08064.13 EWC44815.1 - 0.089 12.7 0.1 0.29 11.1 0.0 1.9 2 1 0 2 2 2 0 UME (NUC010) domain RE_Eco47II PF09553.10 EWC44818.1 - 0.045 13.3 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 Eco47II restriction endonuclease Wza_C PF18412.1 EWC44818.1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Outer-membrane lipoprotein Wza C-terminal domain Fungal_trans PF04082.18 EWC44821.1 - 7.6e-33 113.7 0.2 1.3e-32 112.9 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC44821.1 - 2.1e-06 27.7 13.4 3.9e-06 26.9 13.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EWC44825.1 - 4.1e-83 279.7 26.5 5e-83 279.4 26.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC44825.1 - 4.5e-21 75.2 22.0 1.6e-11 43.7 7.6 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily CHAT PF12770.7 EWC44826.1 - 2.3e-35 122.4 0.0 4.1e-35 121.6 0.0 1.4 1 0 0 1 1 1 1 CHAT domain TPR_10 PF13374.6 EWC44826.1 - 0.00021 21.1 5.3 5 7.1 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC44826.1 - 0.0034 17.7 5.3 3.4 8.0 0.0 5.5 4 1 2 6 6 6 1 Tetratricopeptide repeat ACP_PD PF04336.12 EWC44826.1 - 0.0061 17.0 1.1 9 6.8 0.0 3.6 4 0 0 4 4 4 2 Acyl carrier protein phosphodiesterase BLOC1_2 PF10046.9 EWC44826.1 - 0.031 14.6 0.0 0.2 12.0 0.0 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_8 PF13181.6 EWC44826.1 - 0.079 13.2 1.1 28 5.2 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Laterosporulin PF17861.1 EWC44826.1 - 0.19 12.2 0.4 6.1 7.3 0.0 2.8 2 0 0 2 2 2 0 Laterosporulin defensin-like peptide TPR_1 PF00515.28 EWC44826.1 - 0.44 10.4 2.1 6.5 6.7 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EWC44826.1 - 0.8 9.4 11.5 0.69 9.6 0.2 4.2 5 0 0 5 5 5 0 TPR repeat TPR_2 PF07719.17 EWC44826.1 - 4.4 7.7 9.8 4.9 7.5 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 EWC44826.1 - 7 7.8 6.5 34 5.6 0.0 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat Rib_5-P_isom_A PF06026.14 EWC44827.1 - 6.3e-31 107.3 0.0 8.6e-31 106.9 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Methyltransf_31 PF13847.6 EWC44828.1 - 4e-05 23.5 0.0 6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44828.1 - 5.1e-05 23.9 0.0 0.00022 21.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EWC44828.1 - 7.4e-05 22.4 0.0 0.12 11.9 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase small domain Methyltransf_23 PF13489.6 EWC44828.1 - 0.0013 18.6 0.0 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 EWC44828.1 - 0.0024 18.0 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase N6_Mtase PF02384.16 EWC44828.1 - 0.011 15.0 0.0 0.037 13.3 0.0 1.7 1 1 0 1 1 1 0 N-6 DNA Methylase Ubie_methyltran PF01209.18 EWC44828.1 - 0.028 13.7 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family CheR PF01739.18 EWC44828.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Cons_hypoth95 PF03602.15 EWC44828.1 - 0.14 11.7 0.0 4.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein 95 UPF0020 PF01170.18 EWC44828.1 - 0.16 11.7 0.0 0.69 9.6 0.0 1.9 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 tRNA-synt_1 PF00133.22 EWC44829.1 - 2.1e-50 171.6 0.0 1.2e-30 106.4 0.0 6.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EWC44829.1 - 5.8e-34 117.2 0.0 1.9e-33 115.5 0.0 1.9 2 0 0 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EWC44829.1 - 6.3e-27 94.3 0.1 6.5e-20 71.2 0.0 4.5 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EWC44829.1 - 7.8e-10 38.9 0.0 1.6e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EWC44829.1 - 0.0011 18.4 0.0 0.72 9.1 0.0 2.9 3 1 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain DNA_ligase_ZBD PF03119.16 EWC44829.1 - 0.1 12.6 0.0 0.33 11.0 0.0 1.9 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain zf-ribbon_3 PF13248.6 EWC44829.1 - 0.16 11.4 2.9 3.8 7.1 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EWC44829.1 - 0.97 9.6 4.2 0.7 10.1 0.2 2.7 3 0 0 3 3 3 0 Zinc ribbon domain Mso1_Sec1_bdg PF14475.6 EWC44831.1 - 2.6e-08 33.3 0.0 4.5e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Sec1-binding region of Mso1 TFIIA PF03153.13 EWC44831.1 - 0.11 12.5 12.9 0.17 11.9 12.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC27 PF09507.10 EWC44831.1 - 0.23 10.8 9.1 0.027 13.9 4.4 1.7 1 1 0 2 2 2 0 DNA polymerase subunit Cdc27 Ribosomal_L28e PF01778.17 EWC44832.1 - 1.9e-36 125.3 0.2 1.9e-36 125.3 0.2 2.0 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EWC44832.1 - 3.8e-29 101.2 11.7 3.8e-29 101.2 11.7 3.3 2 1 1 3 3 3 1 Mak16 protein C-terminal region BUD22 PF09073.10 EWC44832.1 - 1.3 8.3 35.6 2.2 7.5 35.6 1.4 1 1 0 1 1 1 0 BUD22 DUF5531 PF17671.1 EWC44832.1 - 2.5 8.0 5.6 0.24 11.3 0.3 1.9 2 1 1 3 3 3 0 Family of unknown function (DUF5531) Nop14 PF04147.12 EWC44832.1 - 3.9 5.6 34.2 5.7 5.0 34.2 1.2 1 0 0 1 1 1 0 Nop14-like family RabGAP-TBC PF00566.18 EWC44833.1 - 1e-37 129.9 4.2 2.2e-37 128.8 4.2 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EWC44833.1 - 8.5e-06 25.3 0.0 0.0045 16.5 0.0 3.2 2 1 0 2 2 2 2 Rab-binding domain (RBD) DUF3655 PF12379.8 EWC44834.1 - 1.5 9.1 7.2 0.22 11.8 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3655) Ank_2 PF12796.7 EWC44835.1 - 3.3e-13 50.0 0.0 0.004 17.7 0.1 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC44835.1 - 4.9e-13 49.3 0.1 9.9e-07 29.2 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC44835.1 - 2e-10 40.0 0.4 0.0016 18.8 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EWC44835.1 - 2.5e-08 34.0 2.8 0.01 16.2 0.3 4.8 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EWC44835.1 - 2.4e-06 27.7 0.0 0.0005 20.3 0.0 2.8 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Aminotran_5 PF00266.19 EWC44837.1 - 9.7e-25 87.3 0.0 6.1e-16 58.3 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V ABC_tran PF00005.27 EWC44838.1 - 6.2e-32 111.0 0.0 8.1e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EWC44838.1 - 8.4e-07 29.5 0.1 1.2e-06 29.0 0.1 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EWC44838.1 - 5.5e-06 26.4 0.0 0.022 14.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EWC44838.1 - 1.8e-05 23.8 0.0 0.00037 19.4 0.0 2.3 2 1 0 2 2 2 1 Predicted ATPase of the ABC class SMC_N PF02463.19 EWC44838.1 - 7.3e-05 22.3 0.1 0.25 10.7 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EWC44838.1 - 0.00032 20.4 0.0 0.00067 19.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EWC44838.1 - 0.00055 20.2 0.0 0.0043 17.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC44838.1 - 0.0015 18.3 0.9 0.017 14.9 0.8 2.2 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EWC44838.1 - 0.0018 17.6 0.1 0.0038 16.5 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.6 EWC44838.1 - 0.01 15.4 0.3 0.47 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EWC44838.1 - 0.027 14.4 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 EWC44838.1 - 0.071 12.8 0.0 0.084 12.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EWC44838.1 - 0.14 12.3 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EWC44838.1 - 0.15 12.6 0.0 0.22 12.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain Abhydrolase_1 PF00561.20 EWC44839.1 - 7e-10 39.0 0.0 4.4e-09 36.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EWC44839.1 - 0.0044 17.7 0.1 0.0057 17.3 0.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC44839.1 - 0.036 13.3 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 HemY_N PF07219.13 EWC44840.1 - 0.051 13.8 0.0 0.057 13.6 0.0 1.1 1 0 0 1 1 1 0 HemY protein N-terminus EGF_CA PF07645.15 EWC44841.1 - 0.065 13.5 6.2 0.16 12.2 6.2 1.7 1 1 0 1 1 1 0 Calcium-binding EGF domain EGF_3 PF12947.7 EWC44841.1 - 1.7 8.9 14.1 0.085 13.1 4.6 2.6 2 0 0 2 2 2 0 EGF domain Ank_2 PF12796.7 EWC44842.1 - 1.8e-17 63.7 1.8 2.1e-07 31.5 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC44842.1 - 3.7e-15 56.1 0.7 6.6e-06 26.6 0.1 4.4 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC44842.1 - 3.8e-11 42.2 3.6 0.14 12.8 0.1 5.8 5 1 1 6 6 6 3 Ankyrin repeat Ank PF00023.30 EWC44842.1 - 4.5e-10 39.5 6.5 4e-05 23.9 0.1 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EWC44842.1 - 4.8e-07 29.9 6.2 0.34 11.3 0.1 5.1 3 1 3 6 6 6 5 Ankyrin repeats (many copies) HeLo PF14479.6 EWC44843.1 - 4.7e-14 52.7 0.4 9.3e-12 45.2 0.0 2.3 2 0 0 2 2 2 2 Prion-inhibition and propagation Catalase PF00199.19 EWC44844.1 - 1.6e-176 587.1 0.0 1.9e-176 586.9 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EWC44844.1 - 3.7e-10 39.8 0.1 1e-09 38.5 0.1 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive GMC_oxred_N PF00732.19 EWC44845.1 - 6.3e-51 173.5 0.0 7.9e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EWC44845.1 - 2.4e-32 112.4 0.0 3.7e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EWC44845.1 - 1.3e-05 24.5 0.1 0.11 11.6 0.4 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 EWC44845.1 - 0.0014 17.9 0.1 0.003 16.9 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EWC44845.1 - 0.0058 15.7 0.0 0.012 14.7 0.0 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EWC44845.1 - 0.0091 15.3 0.0 0.086 12.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EWC44845.1 - 0.036 13.3 0.0 2.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EWC44845.1 - 0.036 14.3 0.0 0.076 13.3 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EWC44845.1 - 0.28 10.7 0.9 1.2 8.6 1.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Piwi PF02171.17 EWC44847.1 - 1.2e-63 215.1 0.0 1.5e-63 214.9 0.0 1.1 1 0 0 1 1 1 1 Piwi domain ArgoL2 PF16488.5 EWC44847.1 - 0.00036 20.8 0.0 0.0011 19.2 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 EWC44848.1 - 2e-05 24.2 0.0 4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 EWC44848.1 - 0.0055 17.3 0.0 0.0095 16.6 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of argonaute PLDc_N PF13396.6 EWC44850.1 - 2e-12 46.8 3.3 3.3e-12 46.1 3.3 1.3 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal DUF4199 PF13858.6 EWC44850.1 - 0.017 15.5 1.5 0.02 15.3 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF3309 PF11752.8 EWC44850.1 - 0.018 15.1 1.7 0.018 15.1 1.7 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3309) FeoB_associated PF12669.7 EWC44850.1 - 0.091 13.2 0.2 4.6 7.7 0.0 2.2 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein FixQ PF05545.11 EWC44850.1 - 0.15 12.1 0.3 0.15 12.1 0.3 1.9 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF2207 PF09972.9 EWC44850.1 - 0.21 10.3 1.2 0.24 10.1 1.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3951 PF13131.6 EWC44850.1 - 0.24 11.6 3.8 0.43 10.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) CENP-F_leu_zip PF10473.9 EWC44851.1 - 8.8e-05 22.6 0.1 0.0001 22.3 0.1 1.0 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EWC44851.1 - 0.00015 22.3 0.1 0.00016 22.2 0.1 1.0 1 0 0 1 1 1 1 Apg6 coiled-coil region HALZ PF02183.18 EWC44851.1 - 0.00029 21.0 0.5 0.00037 20.6 0.5 1.1 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF4140 PF13600.6 EWC44851.1 - 0.0043 17.5 0.1 0.0046 17.4 0.1 1.1 1 0 0 1 1 1 1 N-terminal domain of unknown function (DUF4140) TMF_TATA_bd PF12325.8 EWC44851.1 - 0.0055 16.9 0.2 0.0069 16.6 0.2 1.1 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Lzipper-MIP1 PF14389.6 EWC44851.1 - 0.0072 16.6 0.1 0.0095 16.2 0.1 1.2 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 DivIC PF04977.15 EWC44851.1 - 0.015 15.1 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Septum formation initiator DUF4201 PF13870.6 EWC44851.1 - 0.018 14.8 0.4 0.022 14.5 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) ATG16 PF08614.11 EWC44851.1 - 0.02 15.1 0.8 0.022 15.0 0.8 1.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GTP-bdg_M PF16360.5 EWC44851.1 - 0.022 15.3 0.6 0.042 14.4 0.6 1.5 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region PRKG1_interact PF15898.5 EWC44851.1 - 0.032 15.1 0.2 0.048 14.6 0.2 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Spc7 PF08317.11 EWC44851.1 - 0.074 11.9 0.0 0.082 11.8 0.0 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein NRBF2 PF08961.10 EWC44851.1 - 0.18 11.4 1.7 0.22 11.1 1.6 1.3 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator KAAG1 PF15354.6 EWC44851.1 - 0.2 12.2 0.7 0.29 11.7 0.7 1.3 1 0 0 1 1 1 0 Kidney-associated antigen 1 DUF2235 PF09994.9 EWC44852.1 - 1.4e-90 303.5 0.1 1.8e-90 303.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) bZIP_2 PF07716.15 EWC44853.1 - 0.0099 15.9 10.3 0.025 14.7 5.7 2.2 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 EWC44853.1 - 0.1 12.7 10.8 0.11 12.6 7.6 2.2 2 0 0 2 2 2 0 bZIP transcription factor Peptidase_S28 PF05577.12 EWC44855.1 - 3.3e-59 200.8 0.6 6e-59 199.9 0.6 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Ponericin PF07442.11 EWC44855.1 - 0.15 12.1 0.1 0.35 10.9 0.1 1.6 1 0 0 1 1 1 0 Ponericin MARVEL PF01284.23 EWC44856.1 - 3e-12 46.8 11.0 1.7e-11 44.3 6.5 2.0 1 1 1 2 2 2 2 Membrane-associating domain DUF2157 PF09925.9 EWC44856.1 - 3.6 7.4 7.7 3.6 7.4 4.0 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Claudin_2 PF13903.6 EWC44856.1 - 3.8 7.2 11.4 0.82 9.4 0.7 2.5 1 1 2 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction DUF4231 PF14015.6 EWC44856.1 - 4.2 7.9 4.5 2.6 8.5 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) NUDIX PF00293.28 EWC44862.1 - 1.8e-15 57.1 0.7 5.3e-15 55.6 0.1 1.9 1 1 2 3 3 3 1 NUDIX domain His_Phos_1 PF00300.22 EWC44864.1 - 2.5e-10 40.4 0.0 4.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) F-box-like PF12937.7 EWC44867.1 - 0.02 14.8 0.2 0.063 13.2 0.2 2.0 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.7 EWC44868.1 - 0.0016 18.3 0.6 0.0034 17.2 0.6 1.5 1 0 0 1 1 1 1 F-box-like SMC_ScpB PF04079.16 EWC44868.1 - 0.0035 17.0 0.0 0.0064 16.1 0.0 1.3 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB F-box PF00646.33 EWC44868.1 - 0.09 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 F-box domain F-box PF00646.33 EWC44870.1 - 0.00073 19.4 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EWC44870.1 - 0.0038 17.1 0.2 0.007 16.2 0.2 1.4 1 0 0 1 1 1 1 F-box-like SNAPc19 PF15497.6 EWC44871.1 - 0.11 13.0 0.1 0.39 11.2 0.1 2.0 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 F-box-like PF12937.7 EWC44873.1 - 0.0076 16.1 0.1 0.016 15.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like PI-PLC-X PF00388.19 EWC44876.1 - 7e-59 197.6 0.0 1.2e-58 196.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EWC44876.1 - 2.4e-42 143.9 0.0 4e-42 143.2 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain zf-C2H2_4 PF13894.6 EWC44877.1 - 0.015 16.1 16.9 1 10.4 0.5 5.1 4 1 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EWC44877.1 - 0.016 15.6 0.8 0.016 15.6 0.8 5.5 5 1 0 5 5 5 0 Zinc finger, C2H2 type Sina PF03145.16 EWC44877.1 - 0.032 14.2 5.4 0.055 13.4 5.4 1.3 1 0 0 1 1 1 0 Seven in absentia protein family zf-C2H2_3rep PF18868.1 EWC44877.1 - 1.4 9.6 5.6 0.4 11.4 1.1 2.3 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats CAP PF00188.26 EWC44879.1 - 2.3e-11 44.6 0.7 2.3e-11 44.6 0.7 4.9 3 1 0 3 3 3 1 Cysteine-rich secretory protein family zf-C2H2 PF00096.26 EWC44881.1 - 0.0032 17.8 29.7 0.076 13.5 0.4 5.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type Spt20 PF12090.8 EWC44881.1 - 0.035 13.7 8.2 0.085 12.5 8.2 1.6 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 EWC44881.1 - 9.1 6.2 26.4 0.022 14.8 7.6 3.1 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit AA_permease_2 PF13520.6 EWC44884.1 - 1.2e-76 258.3 32.3 1.6e-76 257.9 32.3 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC44884.1 - 1.2e-15 57.1 25.9 1.6e-15 56.7 25.9 1.2 1 0 0 1 1 1 1 Amino acid permease HNH_2 PF13391.6 EWC44887.1 - 6.5e-10 39.0 0.3 1.3e-09 38.0 0.3 1.5 1 0 0 1 1 1 1 HNH endonuclease FANCM-MHF_bd PF16783.5 EWC44889.1 - 0.035 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 FANCM to MHF binding domain DUF4258 PF14076.6 EWC44890.1 - 0.063 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) DUF2951 PF11166.8 EWC44891.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DAO PF01266.24 EWC44895.1 - 2e-09 37.5 0.0 4.5e-09 36.3 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EWC44895.1 - 0.0018 18.5 0.0 0.0036 17.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EWC44895.1 - 0.0053 16.8 0.0 0.038 14.0 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding MCRA PF06100.11 EWC44895.1 - 0.056 12.2 0.0 0.093 11.5 0.0 1.2 1 0 0 1 1 1 0 MCRA family Pyr_redox_2 PF07992.14 EWC44895.1 - 0.079 12.2 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 7tm_4 PF13853.6 EWC44895.1 - 0.16 11.7 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Olfactory receptor Methyltransf_2 PF00891.18 EWC44896.1 - 5.9e-21 74.7 0.0 7e-20 71.2 0.0 2.2 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EWC44896.1 - 0.013 16.2 0.0 0.049 14.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 EWC44896.1 - 0.17 11.6 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain VIT PF08487.10 EWC44897.1 - 3.9e-29 101.1 0.0 7.2e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EWC44897.1 - 5.6e-26 91.3 0.0 9.8e-26 90.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EWC44897.1 - 4.5e-08 33.5 0.0 1.1e-07 32.3 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EWC44897.1 - 6.6e-06 25.9 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.6 EWC44897.1 - 0.00041 21.0 0.0 0.0014 19.3 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain baeRF_family2 PF18844.1 EWC44897.1 - 0.0057 16.7 0.1 1.4 9.0 0.0 2.5 2 0 0 2 2 2 2 Bacterial archaeo-eukaryotic release factor family 2 VWA_CoxE PF05762.14 EWC44897.1 - 0.034 13.5 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Glyco_hydro_38N PF01074.22 EWC44899.1 - 6.9e-87 291.5 0.5 1.5e-86 290.3 0.5 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EWC44899.1 - 4.3e-57 193.6 0.0 4.9e-56 190.2 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EWC44899.1 - 2.8e-26 91.5 0.2 4e-25 87.8 0.1 2.8 4 0 0 4 4 4 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EWC44899.1 - 1.3e-08 34.8 0.0 3.2e-08 33.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain DUF726 PF05277.12 EWC44900.1 - 4.7e-126 420.3 3.2 6.2e-126 419.9 3.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Peptidase_S55 PF05580.12 EWC44900.1 - 0.049 13.6 0.8 3.8 7.4 0.1 3.1 4 0 0 4 4 4 0 SpoIVB peptidase S55 HSP70 PF00012.20 EWC44901.1 - 2.3e-229 762.6 9.0 2.5e-229 762.4 9.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EWC44901.1 - 3.3e-15 55.7 0.9 8.9e-14 51.0 0.2 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EWC44901.1 - 0.00024 20.9 0.0 0.00066 19.5 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EWC44901.1 - 0.0051 15.8 0.7 0.32 9.9 0.3 2.4 2 0 0 2 2 2 2 Diol dehydratase reactivase ATPase-like domain DUF2524 PF10732.9 EWC44901.1 - 0.058 13.7 0.9 0.18 12.1 0.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) FtsA PF14450.6 EWC44901.1 - 0.15 12.5 6.0 3.4 8.1 0.1 3.5 3 2 0 3 3 3 0 Cell division protein FtsA Glyco_hydro_18 PF00704.28 EWC44902.1 - 8.6e-55 186.7 1.8 1.5e-54 185.8 1.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EWC44902.1 - 2.6e-08 33.8 0.2 0.0044 17.1 0.0 3.0 3 0 0 3 3 3 2 LysM domain Chitin_bind_1 PF00187.19 EWC44902.1 - 3.2e-05 24.3 9.4 3.2e-05 24.3 9.4 4.1 3 0 0 3 3 3 1 Chitin recognition protein STT3 PF02516.14 EWC44905.1 - 5e-149 497.4 39.1 3.7e-145 484.6 35.8 2.2 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit CSN8_PSD8_EIF3K PF10075.9 EWC44906.1 - 8.1e-20 71.3 0.0 1.2e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Peptidase_S58 PF03576.14 EWC44906.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.4 1 1 0 1 1 1 0 Peptidase family S58 Spt5_N PF11942.8 EWC44907.1 - 0.11 13.4 3.4 0.26 12.3 3.4 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Podoplanin PF05808.11 EWC44907.1 - 4 7.5 6.0 6.5 6.8 6.0 1.5 1 0 0 1 1 1 0 Podoplanin SH3_1 PF00018.28 EWC44908.1 - 1e-36 124.3 5.2 1.7e-14 53.1 0.1 4.3 4 0 0 4 4 4 3 SH3 domain SHD1 PF03983.12 EWC44908.1 - 2.1e-32 110.7 0.1 4.4e-32 109.7 0.1 1.6 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_9 PF14604.6 EWC44908.1 - 3.2e-30 103.7 7.8 1.7e-10 40.6 0.1 3.8 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EWC44908.1 - 6.9e-23 80.1 0.0 5.1e-06 26.1 0.0 4.3 4 0 0 4 4 4 3 Variant SH3 domain SAM_4 PF18017.1 EWC44908.1 - 0.0012 18.8 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_10 PF17902.1 EWC44908.1 - 0.0013 18.7 0.0 0.051 13.7 0.0 3.0 3 0 0 3 3 3 1 SH3 domain SH3_3 PF08239.11 EWC44908.1 - 0.055 13.7 3.0 0.86 9.9 0.5 3.4 3 1 0 3 3 3 0 Bacterial SH3 domain Methyltransf_23 PF13489.6 EWC44909.1 - 1.2e-05 25.2 0.0 2.2e-05 24.4 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC44909.1 - 1.5e-05 25.5 0.0 3e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC44909.1 - 2.8e-05 24.8 0.0 5.7e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC44909.1 - 0.0067 17.1 0.0 0.011 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 EWC44909.1 - 0.23 11.0 0.7 0.76 9.3 0.0 1.9 1 1 1 2 2 2 0 AdoMet dependent proline di-methyltransferase Fcf1 PF04900.12 EWC44910.1 - 2e-29 101.9 0.1 3.1e-29 101.3 0.1 1.3 1 0 0 1 1 1 1 Fcf1 Cytomega_UL84 PF06284.11 EWC44910.1 - 0.19 10.1 0.0 0.19 10.1 0.0 1.8 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein zf-Di19 PF05605.12 EWC44911.1 - 0.16 12.2 4.8 0.46 10.8 4.8 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EWC44911.1 - 8.3 7.6 8.6 1.5 9.9 1.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger Rad17 PF03215.15 EWC44913.1 - 2.6e-25 89.4 0.0 4.3e-25 88.7 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EWC44913.1 - 3.2e-06 27.7 0.0 1.3e-05 25.7 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EWC44913.1 - 0.0002 21.8 0.0 0.0011 19.4 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EWC44913.1 - 0.011 16.0 0.0 0.035 14.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EWC44913.1 - 0.022 15.2 0.0 4.6 7.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EWC44913.1 - 0.066 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain zf-H2C2_5 PF13909.6 EWC44914.1 - 0.0046 16.7 3.7 0.007 16.1 0.3 2.5 2 0 0 2 2 2 1 C2H2-type zinc-finger domain DUF3454 PF11936.8 EWC44914.1 - 0.092 13.2 0.3 0.092 13.2 0.3 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF3454) zf-C2H2 PF00096.26 EWC44914.1 - 0.16 12.5 7.9 0.069 13.6 0.8 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type SH3_9 PF14604.6 EWC44915.1 - 3.7e-27 93.9 4.5 2.7e-13 49.6 0.4 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EWC44915.1 - 4.4e-24 83.8 4.2 3.2e-12 45.9 0.2 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EWC44915.1 - 1.7e-17 62.8 0.0 1e-07 31.5 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.20 EWC44915.1 - 9.9e-13 48.0 0.0 2.6e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein F-box-like PF12937.7 EWC44916.1 - 4.3e-05 23.3 0.1 0.0001 22.1 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC44916.1 - 0.0047 16.8 0.2 0.012 15.4 0.2 1.7 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 EWC44917.1 - 5.1e-14 52.4 2.0 0.19 12.7 0.2 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC44917.1 - 0.006 16.9 0.1 3 8.2 0.0 4.1 5 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 EWC44918.1 - 6.5e-21 74.7 0.0 3.4e-10 40.4 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EWC44918.1 - 6.4e-13 48.5 0.7 1.8e-05 24.9 0.1 3.9 2 1 1 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EWC44918.1 - 7.3e-13 47.5 1.0 6.4e-05 23.0 0.1 4.2 4 1 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EWC44918.1 - 1.4e-10 41.5 0.1 3e-05 24.5 0.0 3.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EWC44918.1 - 2.7e-08 33.9 0.5 0.00017 21.8 0.5 3.1 2 2 0 2 2 2 2 Ankyrin repeats (many copies) TPR_19 PF14559.6 EWC44918.1 - 0.0064 17.0 1.8 0.036 14.6 1.5 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Acetyltransf_1 PF00583.25 EWC44919.1 - 3.1e-05 24.2 0.0 5.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC44919.1 - 4.2e-05 23.5 0.0 7.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC44919.1 - 0.0002 21.7 0.0 0.00036 20.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EWC44919.1 - 0.0033 17.3 0.0 0.008 16.1 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EWC44919.1 - 0.0036 17.4 0.0 0.011 15.8 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EWC44919.1 - 0.08 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CHAT PF12770.7 EWC44920.1 - 7.1e-26 91.3 0.0 1.2e-22 80.7 0.0 2.5 2 0 0 2 2 2 2 CHAT domain TPR_2 PF07719.17 EWC44920.1 - 1.4e-07 31.0 18.7 1.6 9.1 0.1 7.4 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EWC44920.1 - 0.00049 20.3 17.3 5.7 7.3 0.1 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EWC44920.1 - 0.013 16.1 3.1 13 6.7 0.2 4.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EWC44920.1 - 0.026 14.3 6.8 23 5.0 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EWC44920.1 - 0.034 14.8 6.3 0.28 11.9 1.4 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC44920.1 - 0.041 14.1 10.9 4.6 7.5 0.5 4.1 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EWC44920.1 - 0.81 10.4 15.7 0.92 10.2 0.3 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EWC44920.1 - 1.2 8.4 13.6 0.33 10.3 3.6 3.3 3 0 0 3 3 3 0 MalT-like TPR region F-box_4 PF15966.5 EWC44921.1 - 0.0092 15.9 0.1 0.024 14.5 0.1 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EWC44921.1 - 0.079 12.9 0.2 0.2 11.6 0.2 1.8 1 0 0 1 1 1 0 F-box-like Nudc_N PF14050.6 EWC44921.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. ADK PF00406.22 EWC44922.1 - 1.7e-39 135.3 0.0 2.1e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EWC44922.1 - 7.2e-17 62.1 0.0 1.1e-16 61.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EWC44922.1 - 1.9e-15 56.5 0.0 3e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EWC44922.1 - 0.00078 20.0 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EWC44922.1 - 0.0028 17.8 0.1 0.0092 16.1 0.1 1.8 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EWC44922.1 - 0.051 13.0 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FliG_M PF14841.6 EWC44922.1 - 0.065 13.5 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 FliG middle domain LETM1 PF07766.13 EWC44923.1 - 8e-105 350.0 1.2 8e-105 350.0 1.2 1.5 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 EWC44923.1 - 0.016 15.0 0.0 0.099 12.4 0.0 2.2 2 0 0 2 2 2 0 SAP domain Gly_transf_sug PF04488.15 EWC44924.1 - 1.9e-11 44.5 0.7 3.4e-11 43.6 0.7 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EWC44924.1 - 0.0098 15.3 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 EWC44924.1 - 0.19 11.0 0.1 0.3 10.3 0.1 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain F-box PF00646.33 EWC44925.1 - 2.5e-06 27.2 0.5 8.6e-05 22.3 0.5 2.5 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EWC44925.1 - 0.03 14.2 0.0 0.25 11.3 0.2 2.3 2 0 0 2 2 2 0 F-box-like SNase PF00565.17 EWC44926.1 - 1.8e-16 60.5 0.0 3e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Ribosomal_L12_N PF16320.5 EWC44926.1 - 0.97 9.2 4.2 0.5 10.1 0.9 2.1 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain DUF5089 PF17002.5 EWC44927.1 - 0.27 11.1 5.3 0.86 9.4 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) Phos_pyr_kin PF08543.12 EWC44929.1 - 5.8e-12 45.5 0.0 9.5e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EWC44929.1 - 3.4e-07 29.9 0.5 2.8e-06 26.8 0.5 2.1 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Glyco_hydro_43 PF04616.14 EWC44929.1 - 0.069 12.4 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 dUTPase PF00692.19 EWC44930.1 - 5.6e-43 145.7 0.0 7.4e-43 145.3 0.0 1.1 1 0 0 1 1 1 1 dUTPase zf-H2C2_2 PF13465.6 EWC44931.1 - 4.9e-09 36.2 13.4 3.9e-05 23.9 0.1 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EWC44931.1 - 8.7e-08 32.2 9.3 2.4e-05 24.5 4.5 3.5 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-met PF12874.7 EWC44931.1 - 4.9e-06 26.8 1.3 1.9e-05 24.8 1.3 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EWC44931.1 - 2.2e-05 24.3 7.7 0.00013 21.9 2.4 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EWC44931.1 - 8.1e-05 23.1 9.1 0.0014 19.3 3.2 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EWC44931.1 - 0.00093 19.4 2.0 0.00093 19.4 2.0 3.0 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EWC44931.1 - 0.024 14.4 6.2 0.61 9.9 0.4 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 EWC44931.1 - 0.05 13.9 0.9 0.05 13.9 0.9 2.9 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Flg_new PF09479.10 EWC44931.1 - 0.11 12.7 0.8 0.29 11.3 0.8 1.7 1 0 0 1 1 1 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) zf-C2HC_2 PF13913.6 EWC44931.1 - 0.32 10.9 3.8 12 6.0 0.2 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-RING_2 PF13639.6 EWC44932.1 - 0.13 12.6 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 Ring finger domain zf-RING_11 PF17123.5 EWC44932.1 - 0.13 12.0 0.3 0.25 11.1 0.3 1.4 1 0 0 1 1 1 0 RING-like zinc finger Rab5ip PF07019.12 EWC44933.1 - 5.6e-25 87.7 7.1 6.5e-25 87.5 7.1 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) WD40 PF00400.32 EWC44934.1 - 1.1e-51 171.6 22.9 3.3e-05 24.5 0.3 12.6 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC44934.1 - 1.9e-27 95.4 5.3 0.00091 19.5 0.1 9.1 2 2 6 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EWC44934.1 - 7.6e-15 55.1 0.0 2.4e-14 53.6 0.0 1.8 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 EWC44934.1 - 4.3e-06 26.3 0.0 0.4 9.9 0.0 4.3 4 0 0 4 4 4 2 WD40-like domain Nup160 PF11715.8 EWC44934.1 - 3.7e-05 22.6 9.1 1.1 7.8 0.0 5.5 4 3 1 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 EWC44934.1 - 0.0013 18.6 0.1 29 4.5 0.0 4.8 4 1 1 5 5 5 0 Eukaryotic translation initiation factor eIF2A MRP-S33 PF08293.11 EWC44934.1 - 0.022 15.0 0.4 0.05 13.8 0.4 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit S27 PALB2_WD40 PF16756.5 EWC44934.1 - 0.08 11.9 3.2 7 5.5 0.0 3.6 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain P34-Arc PF04045.14 EWC44935.1 - 1.7e-110 368.4 0.1 2.1e-110 368.1 0.1 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.12 EWC44935.1 - 0.0036 16.9 0.1 0.012 15.2 0.0 1.9 2 1 0 2 2 2 1 ARP2/3 complex 20 kDa subunit (ARPC4) Vezatin PF12632.7 EWC44937.1 - 5.9e-63 212.9 0.0 9e-63 212.3 0.0 1.2 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes Caps_synth_CapC PF14102.6 EWC44937.1 - 0.055 13.9 0.6 0.096 13.1 0.6 1.3 1 0 0 1 1 1 0 Capsule biosynthesis CapC FAD_binding_2 PF00890.24 EWC44938.1 - 4.2e-85 286.3 0.3 6.3e-85 285.8 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EWC44938.1 - 2.8e-21 75.5 0.0 2.3e-20 72.5 0.0 2.6 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EWC44938.1 - 3.3e-13 50.0 0.1 5.9e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EWC44938.1 - 4.5e-08 32.9 0.7 1.6e-07 31.1 0.7 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EWC44938.1 - 9.1e-08 31.7 1.9 1.7e-06 27.5 0.5 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EWC44938.1 - 3e-07 30.6 0.4 3e-07 30.6 0.4 3.3 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EWC44938.1 - 1.5e-05 24.4 0.5 0.031 13.5 0.0 2.4 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EWC44938.1 - 0.00028 19.7 6.6 0.026 13.2 0.2 3.2 3 0 0 3 3 3 2 HI0933-like protein Amino_oxidase PF01593.24 EWC44938.1 - 0.0013 18.1 0.2 0.21 10.8 0.1 2.4 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 EWC44938.1 - 0.0015 17.9 0.1 0.0023 17.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EWC44938.1 - 0.0024 18.4 0.2 0.18 12.4 0.0 2.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EWC44938.1 - 0.0036 16.6 0.8 0.011 15.0 0.2 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EWC44938.1 - 0.017 14.2 3.1 0.59 9.2 0.8 2.4 2 0 0 2 2 2 0 Glucose inhibited division protein A Thi4 PF01946.17 EWC44938.1 - 0.024 13.9 2.8 1.1 8.5 0.9 2.4 2 0 0 2 2 2 0 Thi4 family tRNA_anti-like PF12869.7 EWC44938.1 - 0.029 14.0 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 tRNA_anti-like NAD_binding_7 PF13241.6 EWC44938.1 - 0.12 12.8 0.0 0.41 11.1 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding Dpy-30 PF05186.13 EWC44939.1 - 2.7e-14 52.6 0.1 4.1e-14 52.0 0.1 1.3 1 0 0 1 1 1 1 Dpy-30 motif SET PF00856.28 EWC44940.1 - 2.7e-07 31.1 0.1 2.8e-06 27.8 0.0 2.4 2 1 0 2 2 2 1 SET domain TPR_19 PF14559.6 EWC44940.1 - 0.0019 18.7 3.3 0.22 12.1 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EWC44940.1 - 0.13 12.4 0.7 6.4 7.2 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-MYND PF01753.18 EWC44940.1 - 7.9 6.7 20.2 0.061 13.4 11.2 2.1 2 0 0 2 2 2 0 MYND finger TauD PF02668.16 EWC44941.1 - 7e-53 180.1 0.2 8.8e-53 179.8 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DAO PF01266.24 EWC44942.1 - 9.1e-24 84.7 2.8 1.3e-23 84.2 2.8 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EWC44942.1 - 0.079 12.0 0.2 0.12 11.4 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EWC44942.1 - 0.095 12.7 0.1 0.46 10.5 0.2 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Amidohydro_1 PF01979.20 EWC44943.1 - 4.3e-32 111.8 0.0 6.4e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EWC44943.1 - 9.1e-13 48.5 0.1 7.4e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family UDPGT PF00201.18 EWC44944.1 - 4.9e-08 32.2 0.1 7.7e-08 31.6 0.1 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_4 PF13692.6 EWC44944.1 - 0.00098 19.6 0.0 0.0026 18.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_tran_28_C PF04101.16 EWC44944.1 - 0.044 13.8 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain SET PF00856.28 EWC44945.1 - 7.8e-11 42.7 0.0 4.2e-10 40.3 0.0 2.1 1 1 0 1 1 1 1 SET domain TPR_2 PF07719.17 EWC44945.1 - 0.00018 21.4 1.1 1.9 8.8 0.0 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC44945.1 - 0.00034 21.2 2.9 1.9 9.5 0.0 4.4 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC44945.1 - 0.011 15.5 0.1 4 7.4 0.0 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EWC44945.1 - 0.036 14.3 0.1 1.3 9.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EWC44945.1 - 0.21 12.1 2.3 1.2 9.7 0.0 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat SET PF00856.28 EWC44946.1 - 5.7e-10 39.8 0.0 2.6e-09 37.7 0.0 2.0 1 1 0 1 1 1 1 SET domain TPR_19 PF14559.6 EWC44946.1 - 0.03 14.8 0.3 0.11 13.0 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat NAD_binding_2 PF03446.15 EWC44947.1 - 2.8e-26 92.6 0.1 4.4e-26 91.9 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EWC44947.1 - 3.9e-08 33.5 0.0 5.9e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_11 PF14833.6 EWC44947.1 - 3.9e-07 30.3 0.3 8.6e-07 29.2 0.3 1.6 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EWC44947.1 - 1.8e-06 28.5 0.1 4e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EWC44947.1 - 0.0012 19.1 0.0 0.002 18.4 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain OCD_Mu_crystall PF02423.15 EWC44947.1 - 0.0034 16.4 0.0 0.0064 15.5 0.0 1.4 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Semialdhyde_dh PF01118.24 EWC44947.1 - 0.019 15.4 0.0 0.04 14.4 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EWC44947.1 - 0.043 13.2 0.3 0.16 11.3 0.0 1.9 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EWC44947.1 - 0.11 13.4 0.0 0.25 12.2 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold CW_binding_2 PF04122.12 EWC44947.1 - 3.9 8.2 5.9 5.8 7.7 0.2 3.1 2 1 0 2 2 2 0 Putative cell wall binding repeat 2 Acetyltransf_1 PF00583.25 EWC44949.1 - 1.3e-12 48.0 0.0 1.9e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EWC44949.1 - 5.1e-09 36.4 0.0 7.6e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EWC44949.1 - 5.2e-09 36.1 0.0 7.6e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EWC44949.1 - 2.1e-05 24.4 0.1 3.9e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EWC44949.1 - 0.0023 18.0 0.0 0.0042 17.2 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EWC44949.1 - 0.0028 17.7 0.1 0.0063 16.6 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EWC44949.1 - 0.0063 17.2 0.0 0.0086 16.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 EWC44949.1 - 0.025 14.3 0.1 0.039 13.7 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_4 PF13420.7 EWC44949.1 - 0.061 13.4 0.0 0.082 13.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AMP-binding PF00501.28 EWC44950.1 - 3.8e-78 263.0 0.0 4.5e-78 262.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC44950.1 - 1.5e-11 45.1 0.0 3.6e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Glyco_hydro_45 PF02015.16 EWC44950.1 - 0.048 13.6 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 45 DUF2076 PF09849.9 EWC44953.1 - 0.11 12.5 0.2 0.12 12.4 0.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) ELO PF01151.18 EWC44954.1 - 1.2e-75 254.3 5.7 1.4e-75 254.1 5.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family RIFIN PF02009.16 EWC44955.1 - 0.00042 20.3 0.4 0.00093 19.2 0.2 1.6 1 1 1 2 2 2 1 Rifin Stevor PF17410.2 EWC44955.1 - 0.054 13.0 0.2 0.11 12.0 0.1 1.5 1 1 0 1 1 1 0 Subtelomeric Variable Open Reading frame DAP10 PF07213.11 EWC44955.1 - 0.08 12.9 0.5 0.2 11.6 0.5 1.6 1 0 0 1 1 1 0 DAP10 membrane protein Adeno_E3_CR2 PF02439.15 EWC44955.1 - 0.18 11.6 0.4 0.48 10.2 0.4 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Apt1 PF10351.9 EWC44955.1 - 1.2 8.0 6.4 1.5 7.6 6.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF2263 PF10021.9 EWC44957.1 - 6.8e-21 75.2 0.0 1.8e-20 73.8 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.21 EWC44957.1 - 0.02 14.9 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 Macro domain ABC_tran PF00005.27 EWC44958.1 - 1e-26 94.1 0.0 1.6e-11 44.9 0.0 3.5 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EWC44958.1 - 7.5e-15 55.5 0.2 0.00041 20.2 0.0 3.8 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EWC44958.1 - 4.4e-10 39.7 0.2 3e-05 24.2 0.1 2.8 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EWC44958.1 - 1.9e-06 27.5 0.0 0.019 14.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EWC44958.1 - 8.4e-05 22.1 0.0 2.4 7.5 0.0 3.8 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EWC44958.1 - 0.00017 22.2 0.1 0.012 16.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EWC44958.1 - 0.00096 19.4 0.1 2.1 8.6 0.1 3.8 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EWC44958.1 - 0.0047 16.7 0.1 8 6.1 0.0 3.5 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_18 PF13238.6 EWC44958.1 - 0.006 17.1 0.0 18 5.9 0.0 3.7 4 0 0 4 4 4 0 AAA domain AAA_15 PF13175.6 EWC44958.1 - 0.0061 16.3 0.0 2.8 7.6 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 EWC44958.1 - 0.013 15.3 0.1 2.4 7.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 EWC44958.1 - 0.022 14.7 0.1 1.8 8.5 0.0 3.0 3 0 0 3 3 3 0 NACHT domain AAA PF00004.29 EWC44958.1 - 0.028 14.8 0.0 1.3 9.5 0.0 2.7 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EWC44958.1 - 0.045 13.7 0.0 13 5.7 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EWC44958.1 - 0.087 12.9 0.0 7.7 6.6 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EWC44958.1 - 0.088 13.0 0.2 7.5 6.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Ad_Cy_reg PF16701.5 EWC44958.1 - 0.11 12.2 0.1 0.52 10.0 0.1 2.0 2 1 1 3 3 3 0 Adenylate cyclase regulatory domain PduV-EutP PF10662.9 EWC44958.1 - 0.21 11.3 0.0 15 5.4 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EWC44958.1 - 0.22 11.9 0.1 20 5.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase ATPase_2 PF01637.18 EWC44958.1 - 0.22 11.4 0.0 3.7 7.4 0.0 2.5 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea TauD PF02668.16 EWC44959.1 - 1.4e-57 195.5 1.8 1.8e-57 195.2 1.8 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family ATG_C PF09333.11 EWC44959.1 - 0.082 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain ARD PF03079.14 EWC44960.1 - 1e-41 142.8 0.0 1.2e-41 142.5 0.0 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EWC44960.1 - 1.7e-09 37.3 0.0 3.6e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EWC44960.1 - 1.5e-05 24.9 0.0 2.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EWC44960.1 - 0.0029 17.2 0.0 0.0046 16.6 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EWC44960.1 - 0.019 14.6 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) GLEYA PF10528.9 EWC44961.1 - 7.8e-57 189.7 10.9 3.2e-30 104.4 1.5 2.9 3 0 0 3 3 3 2 GLEYA domain PA14 PF07691.12 EWC44961.1 - 1.9e-14 53.7 0.0 3.5e-06 26.9 0.0 2.5 2 0 0 2 2 2 2 PA14 domain C1q PF00386.21 EWC44961.1 - 0.028 14.7 0.5 1.9 8.7 0.1 2.6 2 0 0 2 2 2 0 C1q domain Tyrosinase PF00264.20 EWC44962.1 - 3.3e-46 158.3 0.0 5.1e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EWC44962.1 - 5.7e-28 98.0 0.0 1.2e-27 97.0 0.0 1.5 1 0 0 1 1 1 1 Tyosinase C-terminal domain Asp PF00026.23 EWC44963.1 - 4.6e-39 134.7 0.0 6.1e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EWC44963.1 - 0.00016 22.0 0.0 0.00052 20.3 0.0 1.9 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal EphA2_TM PF14575.6 EWC44963.1 - 0.0037 18.1 0.5 0.016 16.0 0.5 2.1 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Tyr-DNA_phospho PF06087.12 EWC44964.1 - 9.1e-114 380.6 0.0 1.5e-113 379.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase BTB PF00651.31 EWC44965.1 - 1.6e-05 25.1 0.0 2.9e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Aldedh PF00171.22 EWC44968.1 - 1.6e-18 66.5 9.0 2.1e-13 49.6 5.0 2.5 1 1 1 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.17 EWC44968.1 - 0.0071 15.5 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) zf-C3HC4 PF00097.25 EWC44969.1 - 3.9e-06 26.6 6.1 1.3e-05 25.0 6.1 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC44969.1 - 1.5e-05 24.9 4.6 1.5e-05 24.9 4.6 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EWC44969.1 - 7.7e-05 22.4 7.4 0.00055 19.7 3.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC44969.1 - 0.0001 22.2 7.2 0.00021 21.2 7.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EWC44969.1 - 0.00037 20.8 10.3 0.0052 17.1 10.6 2.2 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EWC44969.1 - 0.00061 19.6 8.4 0.0032 17.3 3.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EWC44969.1 - 0.0058 16.8 5.3 0.0058 16.8 5.3 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EWC44969.1 - 0.52 10.2 13.9 12 5.8 0.1 3.1 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EWC44969.1 - 2.5 8.3 7.3 0.39 10.9 2.8 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 HTH_32 PF13565.6 EWC44969.1 - 4.9 7.9 9.9 1 10.0 3.5 2.8 3 0 0 3 3 3 0 Homeodomain-like domain Goodbye PF17109.5 EWC44970.1 - 2.5e-28 99.0 0.0 8.1e-28 97.3 0.0 2.0 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain NB-ARC PF00931.22 EWC44970.1 - 4.3e-08 32.6 0.0 1.8e-07 30.6 0.0 2.0 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EWC44970.1 - 1.9e-07 31.6 0.0 5.7e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain TPR_12 PF13424.6 EWC44970.1 - 0.00022 21.5 3.0 0.067 13.5 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EWC44970.1 - 0.048 13.5 3.6 34 4.5 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Ank_5 PF13857.6 EWC44972.1 - 0.0017 18.6 0.0 0.98 9.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC44972.1 - 0.0062 17.0 0.6 11 7.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 EWC44972.1 - 0.0064 17.0 0.0 0.55 10.9 0.0 3.2 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) zf-TRAF PF02176.18 EWC44973.1 - 5e-09 36.7 24.9 1.6e-05 25.5 7.1 4.0 1 1 4 5 5 5 4 TRAF-type zinc finger zf-RING_UBOX PF13445.6 EWC44973.1 - 1.9e-07 31.0 10.6 1.9e-07 31.0 10.6 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EWC44973.1 - 4.5e-06 26.5 4.4 4.5e-06 26.5 4.4 3.1 2 1 1 3 3 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EWC44973.1 - 4.7e-06 26.3 7.7 4.7e-06 26.3 7.7 3.4 3 1 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC44973.1 - 6e-06 26.0 7.3 6e-06 26.0 7.3 3.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC44973.1 - 8.2e-06 25.6 4.1 8.2e-06 25.6 4.1 4.0 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC44973.1 - 0.00021 21.6 6.9 0.00021 21.6 6.9 4.2 2 1 1 3 3 2 1 Ring finger domain zf_C2HC_14 PF18574.1 EWC44973.1 - 0.0012 18.6 0.5 0.0012 18.6 0.5 2.4 2 0 0 2 2 2 1 C2HC Zing finger domain zf-C3HC4_4 PF15227.6 EWC44973.1 - 0.0019 18.3 8.2 0.0019 18.3 8.2 3.5 3 1 1 4 4 3 1 zinc finger of C3HC4-type, RING zf-TRAF_2 PF15965.5 EWC44973.1 - 0.01 16.3 23.6 0.18 12.3 10.5 3.2 2 2 1 3 3 3 0 TRAF-like zinc-finger zf-rbx1 PF12678.7 EWC44973.1 - 0.011 16.0 4.1 0.011 16.0 4.1 3.8 2 2 1 3 3 3 0 RING-H2 zinc finger domain Herpes_BLRF2 PF05812.12 EWC44973.1 - 0.092 12.9 0.3 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein U-box PF04564.15 EWC44973.1 - 0.14 12.4 0.6 1.6 8.9 0.1 2.4 2 0 0 2 2 2 0 U-box domain zf-ACC PF17848.1 EWC44973.1 - 1.8 8.7 5.5 19 5.5 0.7 3.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-Di19 PF05605.12 EWC44973.1 - 1.9 8.8 13.5 0.77 10.1 0.6 3.8 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-Nse PF11789.8 EWC44973.1 - 6.5 6.7 14.5 0.23 11.3 6.2 2.7 2 1 1 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit DUF866 PF05907.13 EWC44974.1 - 5.5e-65 218.0 0.1 6.2e-65 217.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) PHD PF00628.29 EWC44974.1 - 0.0086 16.0 3.1 0.039 13.9 0.9 2.3 2 0 0 2 2 2 1 PHD-finger Rubredoxin_2 PF18073.1 EWC44974.1 - 0.017 14.8 4.7 1.5 8.6 0.4 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain Zn_ribbon_SprT PF17283.2 EWC44974.1 - 0.028 14.3 2.1 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain HalOD2 PF18547.1 EWC44974.1 - 0.18 11.7 4.4 0.69 9.9 4.4 2.1 1 1 0 1 1 1 0 Halobacterial output domain 2 DUF4379 PF14311.6 EWC44974.1 - 0.29 11.5 5.8 1.1 9.7 5.8 2.1 1 1 0 1 1 1 0 Probable Zinc-ribbon domain PRKCSH-like PF12999.7 EWC44975.1 - 2.1e-47 161.2 1.5 2.1e-47 161.2 1.5 2.2 1 1 1 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EWC44975.1 - 1e-29 103.3 2.7 1.9e-29 102.3 0.3 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EWC44975.1 - 3.1e-06 28.1 0.3 1.1e-05 26.3 0.3 2.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Mod_r PF07200.13 EWC44975.1 - 0.0029 17.7 3.8 0.11 12.6 1.6 2.4 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein Phage_GP20 PF06810.11 EWC44975.1 - 0.0059 16.4 4.5 0.0059 16.4 4.5 2.7 3 0 0 3 3 3 1 Phage minor structural protein GP20 Tom22 PF04281.13 EWC44975.1 - 0.007 16.2 1.5 0.12 12.1 0.0 2.8 2 1 0 2 2 2 1 Mitochondrial import receptor subunit Tom22 Fmp27_WPPW PF10359.9 EWC44975.1 - 0.071 12.0 4.3 0.044 12.6 2.2 1.5 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Snapin_Pallidin PF14712.6 EWC44975.1 - 0.11 12.9 1.6 0.29 11.6 0.4 2.2 2 0 0 2 2 2 0 Snapin/Pallidin Filament PF00038.21 EWC44975.1 - 0.13 11.8 11.3 4.8 6.7 4.4 3.0 2 1 1 3 3 3 0 Intermediate filament protein FapA PF03961.13 EWC44975.1 - 0.18 10.4 3.7 0.73 8.4 2.4 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A UPF0242 PF06785.11 EWC44975.1 - 0.32 11.1 4.6 0.58 10.2 2.8 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Prefoldin PF02996.17 EWC44975.1 - 0.33 10.9 5.0 1.9 8.4 1.3 2.6 2 0 0 2 2 2 0 Prefoldin subunit Ldl_recept_a PF00057.18 EWC44975.1 - 0.38 11.0 8.9 0.12 12.6 0.5 2.7 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A Sas6_CC PF18594.1 EWC44975.1 - 0.41 10.5 5.1 0.1 12.4 1.2 2.1 2 0 0 2 2 1 0 Sas6/XLF/XRCC4 coiled-coil domain HalX PF08663.10 EWC44975.1 - 0.55 10.6 5.6 6.2 7.2 0.3 2.8 2 0 0 2 2 2 0 HalX domain CC2-LZ PF16516.5 EWC44975.1 - 0.61 10.5 9.4 0.97 9.8 0.1 2.7 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator LMP PF04778.12 EWC44975.1 - 0.63 9.9 5.8 0.16 11.9 1.7 2.0 2 0 0 2 2 2 0 LMP repeated region ATG16 PF08614.11 EWC44975.1 - 0.71 10.1 14.4 5.9 7.1 8.0 2.9 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EWC44975.1 - 1.2 9.2 12.8 0.86 9.7 0.7 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein KxDL PF10241.9 EWC44975.1 - 1.5 9.2 5.3 7.4 6.9 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein DUF4407 PF14362.6 EWC44975.1 - 1.9 7.7 8.9 2.1 7.6 3.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.20 EWC44975.1 - 3 7.8 14.7 4.8 7.2 0.0 3.3 3 0 0 3 3 3 0 Prefoldin subunit Sec2p PF06428.11 EWC44975.1 - 3.4 7.7 11.6 3.6 7.6 0.1 3.3 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p FadA PF09403.10 EWC44975.1 - 4.2 7.9 9.1 1 9.9 1.5 3.0 3 0 0 3 3 3 0 Adhesion protein FadA G_path_suppress PF15991.5 EWC44975.1 - 9.8 6.2 12.4 20 5.2 12.4 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor ATP-synt PF00231.19 EWC44978.1 - 0.0052 16.6 0.1 0.0065 16.2 0.1 1.1 1 0 0 1 1 1 1 ATP synthase Trypan_PARP PF05887.11 EWC44979.1 - 0.33 10.9 14.6 0.67 9.9 14.6 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 EWC44979.1 - 2.2 8.8 19.2 0.065 13.7 11.8 2.2 2 0 0 2 2 2 0 TonB polyproline region Steroid_dh PF02544.16 EWC44980.1 - 5.9e-28 97.7 0.1 1e-27 97.0 0.1 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase T6SS_HCP PF05638.12 EWC44980.1 - 0.021 15.3 0.0 0.15 12.5 0.0 1.9 2 0 0 2 2 2 0 Type VI secretion system effector, Hcp DUF1295 PF06966.12 EWC44980.1 - 0.048 13.2 0.1 0.068 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) USP7_ICP0_bdg PF12436.8 EWC44980.1 - 0.057 12.7 0.0 0.083 12.2 0.0 1.1 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 SUR7 PF06687.12 EWC44981.1 - 9e-27 94.1 10.3 1.2e-26 93.7 10.3 1.2 1 0 0 1 1 1 1 SUR7/PalI family Amidohydro_1 PF01979.20 EWC44983.1 - 3e-14 53.1 0.0 4.6e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EWC44983.1 - 6.1e-12 45.8 0.1 3.4e-08 33.4 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Ribosomal_L37 PF08561.10 EWC44984.1 - 0.39 11.2 5.2 0.78 10.3 5.2 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 ACBP PF00887.19 EWC44985.1 - 3.7e-29 100.8 0.1 4e-29 100.7 0.1 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein HD_3 PF13023.6 EWC44986.1 - 1.6e-41 141.9 0.2 2e-41 141.6 0.2 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EWC44986.1 - 2.5e-11 43.7 0.2 4.2e-11 42.9 0.2 1.4 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EWC44986.1 - 1.1e-06 28.9 0.0 1.7e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 HD domain SNARE_assoc PF09335.11 EWC44987.1 - 1.7e-11 44.6 5.8 1.7e-11 44.6 5.8 2.1 2 1 0 2 2 2 1 SNARE associated Golgi protein p450 PF00067.22 EWC44990.1 - 1.9e-61 208.2 0.0 2.5e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.13 EWC44991.1 - 5.4e-62 209.1 10.1 5.4e-62 209.1 10.1 1.6 2 0 0 2 2 2 1 RTA1 like protein UNC-50 PF05216.13 EWC44991.1 - 0.0034 17.0 3.6 0.042 13.4 0.0 2.3 2 0 0 2 2 2 1 UNC-50 family SUIM_assoc PF16619.5 EWC44992.1 - 0.0094 16.0 18.8 0.08 13.0 2.1 2.8 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 SARAF PF06682.12 EWC44992.1 - 0.086 12.5 2.2 0.14 11.8 2.2 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Eaf7 PF07904.13 EWC44992.1 - 0.14 12.6 0.6 0.48 10.8 0.2 2.1 3 0 0 3 3 3 0 Chromatin modification-related protein EAF7 Hydin_ADK PF17213.3 EWC44992.1 - 2.4 8.4 4.7 5.7 7.2 4.0 1.9 2 1 0 2 2 2 0 Hydin Adenylate kinase-like domain DUF2418 PF10332.9 EWC44993.1 - 4.8e-28 97.5 0.4 8.5e-28 96.7 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) YtpI PF14007.6 EWC44993.1 - 0.71 10.0 3.2 8.8 6.6 0.2 2.6 2 0 0 2 2 2 0 YtpI-like protein NUDIX PF00293.28 EWC44994.1 - 2.1e-18 66.6 0.1 3.2e-18 66.0 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EWC44994.1 - 1.2e-08 35.5 0.4 4.8e-08 33.6 0.2 2.0 2 0 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EWC44994.1 - 2.6e-06 27.0 3.4 4.4e-06 26.2 3.4 1.3 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain BBS2_Mid PF14783.6 EWC44995.1 - 0.086 12.9 0.3 0.57 10.2 0.0 2.5 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region LYRIC PF15686.5 EWC44996.1 - 0.0055 16.3 0.1 0.0094 15.6 0.1 1.3 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family MARVEL PF01284.23 EWC44996.1 - 0.026 14.5 8.9 0.063 13.3 8.9 1.6 1 1 0 1 1 1 0 Membrane-associating domain DUF202 PF02656.15 EWC44996.1 - 0.12 12.9 2.5 0.34 11.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF202) PUL PF08324.11 EWC44996.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 PUL domain zf-CHY PF05495.12 EWC44997.1 - 3.3e-14 53.1 11.9 6.9e-14 52.1 11.9 1.5 1 1 0 1 1 1 1 CHY zinc finger Zn_ribbon_SprT PF17283.2 EWC44997.1 - 0.0012 18.7 1.3 0.19 11.7 0.1 2.6 2 0 0 2 2 2 1 SprT-like zinc ribbon domain DpnI PF06044.12 EWC44997.1 - 0.02 14.5 1.5 0.02 14.5 1.5 1.8 1 1 1 2 2 2 0 Dam-replacing family Anti-TRAP PF15777.5 EWC44997.1 - 0.021 14.8 2.9 0.046 13.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EWC44997.1 - 0.027 14.5 2.2 0.027 14.5 2.2 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cys_rich_KTR PF14205.6 EWC44997.1 - 0.036 13.9 7.3 1.2 9.0 2.6 2.7 1 1 1 2 2 2 0 Cysteine-rich KTR DUF3909 PF13077.6 EWC44997.1 - 0.077 13.1 0.0 0.097 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3909) Zn-ribbon_8 PF09723.10 EWC44997.1 - 0.14 12.3 14.2 0.068 13.3 4.5 2.5 1 1 2 3 3 3 0 Zinc ribbon domain zf-C2H2 PF00096.26 EWC44997.1 - 0.17 12.4 7.7 4.7 7.9 0.5 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type zinc_ribbon_4 PF13717.6 EWC44997.1 - 0.28 11.2 11.3 4.7 7.2 0.1 3.4 2 1 1 3 3 3 0 zinc-ribbon domain DUF3797 PF12677.7 EWC44997.1 - 0.45 10.4 6.8 0.33 10.9 0.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) NOB1_Zn_bind PF08772.11 EWC44997.1 - 0.63 10.2 7.6 0.086 13.0 3.0 2.1 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-UDP PF14569.6 EWC44997.1 - 2.2 8.5 9.6 1.6 8.9 6.1 2.2 1 1 1 2 2 2 0 Zinc-binding RING-finger Proteasome PF00227.26 EWC44998.1 - 2.2e-56 190.3 0.0 3.5e-56 189.7 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EWC44998.1 - 5.9e-13 48.2 0.3 2.1e-12 46.5 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature FAD-oxidase_C PF02913.19 EWC44999.1 - 1e-57 195.6 0.0 1.4e-57 195.3 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EWC44999.1 - 2.8e-35 121.1 0.3 5.1e-35 120.2 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain WD40 PF00400.32 EWC45000.1 - 7.2e-27 93.1 13.4 4.8e-05 24.0 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat PQQ_3 PF13570.6 EWC45000.1 - 1.3e-07 31.8 6.1 0.031 14.8 0.1 5.4 5 1 1 6 6 6 2 PQQ-like domain ANAPC4_WD40 PF12894.7 EWC45000.1 - 2.1e-06 27.9 0.1 1 9.7 0.0 4.9 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC45000.1 - 0.00047 18.9 0.9 1.6 7.3 0.0 3.4 1 1 1 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EWC45000.1 - 0.001 19.1 0.0 5.5 7.1 0.0 4.0 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 EWC45000.1 - 0.028 13.4 0.1 13 4.6 0.0 3.0 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 EWC45000.1 - 0.044 14.1 0.7 0.92 9.9 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Frtz PF11768.8 EWC45000.1 - 0.13 10.5 0.0 0.4 8.9 0.0 1.7 1 1 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz PKD PF00801.20 EWC45000.1 - 0.18 11.7 2.2 0.68 9.8 0.5 2.8 2 1 0 2 2 2 0 PKD domain SKIP_SNW PF02731.15 EWC45001.1 - 3.6e-72 241.3 2.1 3.6e-72 241.3 2.1 2.2 2 0 0 2 2 2 1 SKIP/SNW domain Tom5 PF10642.9 EWC45001.1 - 0.3 11.2 1.0 1.5 8.9 1.0 2.2 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase BCDHK_Adom3 PF10436.9 EWC45002.1 - 8.5e-43 146.0 0.0 1.6e-42 145.1 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EWC45002.1 - 2.8e-05 24.6 0.0 0.00016 22.2 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase USP7_ICP0_bdg PF12436.8 EWC45003.1 - 4.7e-81 271.6 0.1 4.1e-80 268.6 0.0 2.4 3 0 0 3 3 3 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EWC45003.1 - 9.1e-74 247.6 2.7 1.9e-69 233.5 1.7 3.5 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 EWC45003.1 - 1.4e-48 165.7 0.1 2.8e-48 164.7 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EWC45003.1 - 5.8e-23 82.0 0.0 4.3e-22 79.1 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EWC45003.1 - 0.076 12.8 0.0 8.9 6.1 0.0 3.8 4 1 0 4 4 4 0 Ubiquitin family EMP24_GP25L PF01105.24 EWC45004.1 - 3.8e-43 147.6 1.8 4.8e-43 147.2 1.8 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_C48 PF02902.19 EWC45005.1 - 1.5e-38 132.8 0.0 2.5e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF5136 PF17199.4 EWC45005.1 - 6.2 6.6 8.0 0.36 10.5 0.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF5136) HDA2-3 PF11496.8 EWC45006.1 - 2.8e-21 76.0 0.5 1.2e-18 67.3 0.0 3.0 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DASH_Spc34 PF08657.10 EWC45006.1 - 2.7e-05 24.1 0.6 9.9e-05 22.3 0.6 2.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 KRAB PF01352.27 EWC45006.1 - 0.026 14.2 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 KRAB box TACC_C PF05010.14 EWC45006.1 - 0.036 13.8 21.2 0.27 11.0 20.4 2.2 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal HAP1_N PF04849.13 EWC45006.1 - 0.22 10.7 21.4 0.056 12.6 9.1 2.3 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Cnn_1N PF07989.11 EWC45006.1 - 0.27 11.4 11.5 1.2 9.4 0.1 3.2 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 KxDL PF10241.9 EWC45006.1 - 0.39 11.0 5.0 0.17 12.2 1.4 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein Mst1_SARAH PF11629.8 EWC45006.1 - 1.2 9.3 6.2 5.5 7.2 0.7 2.9 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Fib_alpha PF08702.10 EWC45006.1 - 3.1 8.0 8.4 3.4 7.8 0.9 2.8 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Nup54 PF13874.6 EWC45006.1 - 4.6 7.4 18.8 0.31 11.1 5.4 2.8 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 FMO-like PF00743.19 EWC45007.1 - 6.8e-46 156.8 0.1 5.1e-22 78.0 0.1 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EWC45007.1 - 1.2e-16 60.8 0.0 2.1e-16 60.0 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EWC45007.1 - 1.1e-15 57.8 0.5 1.7e-12 47.2 0.4 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EWC45007.1 - 1e-08 34.7 2.0 4.8e-07 29.2 0.2 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EWC45007.1 - 2.3e-06 27.7 0.0 1.3e-05 25.2 0.0 2.3 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EWC45007.1 - 8.6e-06 25.9 0.0 1.8e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EWC45007.1 - 1.4e-05 24.5 0.2 0.0089 15.3 0.1 2.2 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 EWC45007.1 - 0.00012 21.8 0.1 0.18 11.3 0.1 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EWC45007.1 - 0.00016 20.5 0.8 0.034 12.9 0.2 2.4 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox PF00070.27 EWC45007.1 - 0.0015 19.1 0.0 0.93 10.1 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EWC45007.1 - 0.0024 17.3 0.2 0.0057 16.0 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EWC45007.1 - 0.0043 16.3 0.2 0.0097 15.2 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Amino_oxidase PF01593.24 EWC45007.1 - 0.014 14.7 0.0 3 7.0 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Mqo PF06039.15 EWC45007.1 - 0.024 13.2 0.0 0.037 12.6 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Citrate_synt PF00285.21 EWC45007.1 - 0.065 12.3 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain FAD_binding_2 PF00890.24 EWC45007.1 - 0.095 11.8 0.0 0.22 10.6 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain POT1 PF02765.17 EWC45009.1 - 0.00047 20.0 0.0 0.00098 19.0 0.0 1.5 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 CDC45 PF02724.14 EWC45009.1 - 0.043 12.1 19.6 0.074 11.3 19.6 1.3 1 0 0 1 1 1 0 CDC45-like protein RPN2_C PF18004.1 EWC45009.1 - 0.14 12.0 11.2 0.37 10.7 11.2 1.7 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 EWC45009.1 - 0.28 9.4 31.4 0.52 8.5 31.4 1.4 1 0 0 1 1 1 0 Nop14-like family Connexin PF00029.19 EWC45009.1 - 1.9 8.2 5.3 3.4 7.3 5.3 1.3 1 0 0 1 1 1 0 Connexin Tim54 PF11711.8 EWC45009.1 - 2.7 6.7 11.5 12 4.5 12.1 1.7 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SH3_2 PF07653.17 EWC45010.1 - 1.4e-08 34.3 0.2 2.6e-08 33.4 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain Transglut_core PF01841.19 EWC45010.1 - 3.4e-08 33.9 0.1 7.1e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_1 PF00018.28 EWC45010.1 - 2e-07 30.5 0.1 4.7e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC45010.1 - 0.0024 17.7 0.1 0.005 16.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain GGACT PF06094.12 EWC45011.1 - 5e-18 65.9 0.0 7.1e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like COG2 PF06148.11 EWC45012.1 - 1.1e-30 106.4 0.2 3.1e-30 105.0 0.0 1.8 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EWC45012.1 - 0.017 15.2 0.1 0.052 13.6 0.0 1.9 2 0 0 2 2 2 0 Vps51/Vps67 DUF1045 PF06299.12 EWC45012.1 - 0.054 13.5 0.3 0.15 12.0 0.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1045) Ribosomal_L1 PF00687.21 EWC45013.1 - 3.3e-31 108.6 0.2 4.3e-31 108.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SRP54 PF00448.22 EWC45014.1 - 5.3e-76 254.6 1.5 8.9e-76 253.9 1.1 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EWC45014.1 - 1.4e-31 109.0 4.4 1.4e-31 109.0 4.4 3.3 3 1 0 3 3 2 1 Signal peptide binding domain SRP54_N PF02881.19 EWC45014.1 - 3e-19 69.0 0.6 9.4e-19 67.4 0.6 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EWC45014.1 - 2.9e-06 27.0 1.0 2.3e-05 24.1 1.0 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EWC45014.1 - 5.7e-06 26.5 0.0 1.2e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EWC45014.1 - 0.00059 19.9 0.0 0.0017 18.4 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EWC45014.1 - 0.00059 20.1 0.0 0.0017 18.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EWC45014.1 - 0.00098 19.6 0.1 0.00098 19.6 0.1 2.6 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 EWC45014.1 - 0.0012 18.2 0.0 0.0042 16.4 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin MeaB PF03308.16 EWC45014.1 - 0.0013 17.8 0.8 0.016 14.2 0.8 2.4 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 EWC45014.1 - 0.0041 17.0 0.0 0.0086 16.0 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 EWC45014.1 - 0.0051 16.5 0.8 0.0094 15.7 0.1 1.9 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 EWC45014.1 - 0.0056 17.2 0.0 0.015 15.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EWC45014.1 - 0.0061 16.3 0.3 0.028 14.1 0.0 2.2 2 0 0 2 2 2 1 Thymidylate kinase AAA_16 PF13191.6 EWC45014.1 - 0.0064 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MobB PF03205.14 EWC45014.1 - 0.007 16.3 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.23 EWC45014.1 - 0.0085 16.2 0.4 0.056 13.5 0.1 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EWC45014.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SRPRB PF09439.10 EWC45014.1 - 0.017 14.6 1.1 1.5 8.3 0.1 2.9 2 1 0 3 3 3 0 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 EWC45014.1 - 0.019 14.8 1.7 0.048 13.4 0.0 2.5 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 EWC45014.1 - 0.02 15.2 0.1 0.064 13.6 0.1 1.9 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 EWC45014.1 - 0.023 13.6 0.0 0.05 12.5 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ResIII PF04851.15 EWC45014.1 - 0.026 14.5 0.2 0.068 13.2 0.2 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DUF1611 PF07755.11 EWC45014.1 - 0.035 13.4 0.1 0.08 12.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain AAA_28 PF13521.6 EWC45014.1 - 0.038 14.2 0.1 0.077 13.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_31 PF13614.6 EWC45014.1 - 0.073 13.0 0.0 0.22 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain KduI PF04962.12 EWC45014.1 - 0.1 11.9 0.2 3.3 6.9 0.0 2.3 2 0 0 2 2 2 0 KduI/IolB family NMT1 PF09084.11 EWC45015.1 - 0.018 15.0 0.0 3.5 7.5 0.0 2.2 2 0 0 2 2 2 0 NMT1/THI5 like LysR_substrate PF03466.20 EWC45015.1 - 0.067 12.5 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 LysR substrate binding domain CTD_bind PF04818.13 EWC45016.1 - 6e-09 36.6 0.0 2.1e-08 34.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. RR_TM4-6 PF06459.12 EWC45016.1 - 9.8 5.9 5.9 15 5.3 5.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Glucosaminidase PF01832.20 EWC45017.1 - 0.12 12.9 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Pmp3 PF01679.17 EWC45018.1 - 3.6e-21 75.1 11.0 5.1e-21 74.6 11.0 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RRM_1 PF00076.22 EWC45019.1 - 2.2e-20 72.2 0.1 2.6e-10 40.0 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EWC45019.1 - 0.12 12.5 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif ACT_7 PF13840.6 EWC45020.1 - 3.5e-25 87.6 0.0 1.2e-17 63.4 0.0 2.4 2 0 0 2 2 2 2 ACT domain DUF2007 PF09413.10 EWC45020.1 - 0.053 13.7 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein RLAN PF14401.6 EWC45020.1 - 0.12 12.0 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 RimK-like ATPgrasp N-terminal domain SPC22 PF04573.12 EWC45021.1 - 5.1e-50 169.3 0.5 5.7e-50 169.1 0.5 1.0 1 0 0 1 1 1 1 Signal peptidase subunit XRN_M PF17846.1 EWC45022.1 - 1.2e-96 324.4 0.5 2.2e-96 323.5 0.5 1.4 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EWC45022.1 - 6.5e-95 317.2 0.0 9.8e-95 316.6 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EWC45022.1 - 3.4e-66 222.7 0.0 6.2e-66 221.8 0.0 1.4 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EWC45022.1 - 1.1e-27 96.1 0.0 2.5e-27 94.9 0.0 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EWC45022.1 - 7.9e-23 80.4 0.3 1.7e-22 79.3 0.3 1.6 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 EWC45022.1 - 1.4e-08 34.7 0.1 3.3e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 CAF1C_H4-bd PF12265.8 EWC45023.1 - 1.8e-27 95.4 0.3 1.3e-26 92.6 0.1 2.5 2 1 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EWC45023.1 - 1e-22 79.9 10.6 3.8e-05 24.4 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat SEP PF08059.13 EWC45024.1 - 3.9e-24 85.0 0.1 1.2e-23 83.5 0.0 1.9 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EWC45024.1 - 2.2e-18 66.2 0.0 5.7e-18 64.9 0.0 1.7 2 0 0 2 2 2 1 UBX domain UBA_4 PF14555.6 EWC45024.1 - 7.2e-12 44.9 0.0 1.2e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 EWC45024.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 TAP C-terminal domain ADK PF00406.22 EWC45025.1 - 5e-62 208.5 0.0 6.3e-62 208.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EWC45025.1 - 3.6e-24 85.7 0.3 1.6e-23 83.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EWC45025.1 - 5.1e-17 61.6 0.0 1.2e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EWC45025.1 - 4.9e-05 23.9 0.0 9.4e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EWC45025.1 - 0.0021 18.2 0.0 0.0036 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain CFIA_Pcf11 PF11526.8 EWC45026.1 - 1.4e-11 44.7 0.2 1.4e-11 44.7 0.2 2.5 3 0 0 3 3 3 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 EWC45026.1 - 5.5e-06 27.1 0.0 2.5e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase II-binding domain. VHS PF00790.19 EWC45026.1 - 0.00075 19.4 0.0 0.0021 17.9 0.0 1.7 1 0 0 1 1 1 1 VHS domain zf_UBZ PF18439.1 EWC45026.1 - 0.023 14.3 1.6 2.1 8.0 0.1 2.6 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Mito_carr PF00153.27 EWC45027.1 - 1.5e-29 101.8 0.8 2.2e-14 53.1 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein IGPS PF00218.21 EWC45028.1 - 5.3e-94 314.1 0.1 1.1e-93 313.1 0.0 1.5 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EWC45028.1 - 1.3e-47 162.1 0.0 2e-43 148.5 0.0 2.2 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EWC45028.1 - 2.2e-45 154.8 0.0 3.8e-45 154.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EWC45028.1 - 1.2e-06 28.5 0.3 2.3e-05 24.2 0.3 2.4 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 EWC45028.1 - 0.043 13.6 0.1 0.14 11.9 0.1 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Nup188 PF10487.9 EWC45029.1 - 4.3e-83 279.8 0.0 3.2e-79 267.0 0.0 3.1 3 1 0 3 3 3 2 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 EWC45029.1 - 9.6e-61 205.7 2.6 1.8e-60 204.8 2.6 1.5 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup192 PF11894.8 EWC45029.1 - 0.00043 17.6 0.0 0.00078 16.7 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 PI-PLC-X PF00388.19 EWC45030.1 - 1.1e-58 196.9 0.0 2.2e-58 196.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EWC45030.1 - 2.5e-43 147.1 0.0 5.5e-43 146.0 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EWC45030.1 - 7.2e-09 35.9 0.0 3.9e-08 33.5 0.0 2.2 1 1 0 1 1 1 1 C2 domain EF-hand_10 PF14788.6 EWC45030.1 - 3.4e-05 23.6 0.2 7.2e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EWC45030.1 - 0.00017 21.9 7.1 0.0036 17.7 1.8 2.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EWC45030.1 - 0.0021 17.9 0.7 0.022 14.6 0.2 2.9 2 0 0 2 2 2 1 EF-hand domain PH_12 PF16457.5 EWC45030.1 - 0.0026 18.3 0.0 0.0077 16.8 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_1 PF00036.32 EWC45030.1 - 0.0073 15.8 1.2 0.03 13.9 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_like PF09279.11 EWC45030.1 - 0.0088 16.5 0.1 0.023 15.1 0.1 1.8 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like Med3 PF11593.8 EWC45030.1 - 0.016 14.4 1.2 0.026 13.7 1.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PH_14 PF17787.1 EWC45030.1 - 0.13 12.2 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 PH domain HAD_2 PF13419.6 EWC45031.1 - 8.5e-08 32.5 0.0 2.7e-07 30.9 0.0 1.7 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EWC45031.1 - 0.0048 17.2 0.0 0.016 15.5 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EWC45031.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Brix PF04427.18 EWC45032.1 - 1.3e-30 107.0 0.1 1.6e-30 106.6 0.1 1.1 1 0 0 1 1 1 1 Brix domain Ribosomal_L5e PF17144.4 EWC45033.1 - 7.3e-81 270.0 0.2 1.1e-80 269.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EWC45033.1 - 2.3e-34 118.2 6.0 2.3e-34 118.2 6.0 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Thr_synth_N PF14821.6 EWC45033.1 - 0.032 14.5 0.1 0.65 10.3 0.0 2.7 2 0 0 2 2 2 0 Threonine synthase N terminus XPG_N PF00752.17 EWC45034.1 - 1.3e-31 109.0 0.3 3.8e-31 107.5 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EWC45034.1 - 4.4e-31 107.1 2.2 1.8e-30 105.1 0.1 2.5 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 EWC45034.1 - 1.2e-06 29.0 0.4 7.5e-06 26.5 0.0 2.4 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EWC45034.1 - 0.0043 17.6 0.0 0.014 16.0 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 EWC45034.1 - 0.028 14.5 0.0 0.073 13.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif NDUFV3 PF15880.5 EWC45034.1 - 0.11 12.6 1.3 0.21 11.6 1.3 1.5 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Acyl-CoA_dh_1 PF00441.24 EWC45035.1 - 8.4e-22 78.0 0.0 1.2e-21 77.5 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EWC45035.1 - 1.4e-16 60.4 0.0 2.1e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EWC45035.1 - 2.6e-06 27.7 0.2 1.3e-05 25.5 0.2 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EWC45035.1 - 0.12 13.0 0.0 0.23 12.1 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain UQ_con PF00179.26 EWC45036.1 - 1.8e-52 176.7 0.0 2e-52 176.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EWC45036.1 - 0.036 14.4 0.0 0.043 14.1 0.0 1.2 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 EWC45036.1 - 0.037 13.7 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 EWC45036.1 - 0.042 13.7 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 UEV domain TLD PF07534.16 EWC45037.1 - 6e-33 114.0 0.0 7.8e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 TLD Sel1 PF08238.12 EWC45038.1 - 9.5e-17 61.1 13.4 7.6e-06 26.4 0.0 6.5 6 1 0 6 6 6 5 Sel1 repeat TPR_1 PF00515.28 EWC45038.1 - 0.00052 19.7 0.5 0.0095 15.7 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EWC45038.1 - 1.3 9.3 5.8 2.5 8.5 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat NAD_binding_6 PF08030.12 EWC45039.1 - 1.8e-33 115.9 0.0 3.2e-33 115.1 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EWC45039.1 - 6e-22 77.8 0.0 1.1e-20 73.8 0.0 2.5 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 EWC45039.1 - 3.8e-17 62.6 13.0 3.8e-17 62.6 13.0 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DUF2017 PF09438.10 EWC45039.1 - 0.014 15.3 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2017) TFIID_20kDa PF03847.13 EWC45040.1 - 1.5e-27 95.9 0.4 1.5e-27 95.9 0.4 1.6 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 EWC45040.1 - 0.017 15.5 0.0 0.065 13.6 0.0 2.0 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EWC45040.1 - 0.056 13.5 0.5 0.58 10.2 0.0 2.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 EWC45040.1 - 0.13 12.5 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Spectrin PF00435.21 EWC45040.1 - 0.15 12.6 4.8 4.3 7.9 0.1 3.4 3 0 0 3 3 3 0 Spectrin repeat DUF2434 PF10361.9 EWC45042.1 - 2.5e-92 309.0 7.3 3.7e-92 308.4 7.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) Jagunal PF07086.12 EWC45042.1 - 0.97 9.5 5.1 0.26 11.3 0.5 2.2 2 0 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis 7tm_7 PF08395.12 EWC45042.1 - 1 8.5 16.1 0.87 8.7 11.7 2.4 1 1 1 2 2 2 0 7tm Chemosensory receptor Rpn3_C PF08375.11 EWC45043.1 - 7e-28 96.9 4.0 1.6e-27 95.7 4.0 1.6 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EWC45043.1 - 1.5e-20 73.7 0.1 9.2e-20 71.1 0.1 2.3 2 0 0 2 2 2 1 PCI domain Vma12 PF11712.8 EWC45044.1 - 3.6e-30 104.9 0.1 4.7e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Chordopox_A13L PF05961.11 EWC45044.1 - 0.007 16.6 0.1 0.014 15.6 0.1 1.4 1 0 0 1 1 1 1 Chordopoxvirus A13L protein DUF2512 PF10710.9 EWC45044.1 - 0.024 14.3 0.1 0.039 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2512) MMgT PF10270.9 EWC45044.1 - 0.05 14.0 0.5 1.7 9.0 0.1 2.2 2 0 0 2 2 2 0 Membrane magnesium transporter Lig_chan PF00060.26 EWC45044.1 - 0.067 13.0 0.1 0.16 11.8 0.1 1.5 1 1 0 1 1 1 0 Ligand-gated ion channel UDPG_MGDP_dh_N PF03721.14 EWC45045.1 - 4e-59 199.3 0.0 7.8e-59 198.4 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 EWC45045.1 - 2.4e-33 114.7 0.1 7.5e-33 113.1 0.1 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 EWC45045.1 - 1.5e-30 105.2 0.0 3e-30 104.3 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sacchrp_dh_NADP PF03435.18 EWC45045.1 - 0.053 13.8 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EWC45045.1 - 0.065 13.4 0.0 1.8 8.7 0.0 2.6 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Thi4 PF01946.17 EWC45045.1 - 0.079 12.2 0.3 4.8 6.4 0.1 2.4 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.21 EWC45045.1 - 0.12 11.6 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain XPG_I PF00867.18 EWC45046.1 - 1.4e-22 79.8 0.0 2.7e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 EWC45046.1 - 4.8e-09 36.1 0.0 7.3e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 EWC45046.1 - 0.0011 19.4 0.0 0.0027 18.2 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain UxaE PF16257.5 EWC45046.1 - 0.0065 15.2 0.0 0.0094 14.6 0.0 1.1 1 0 0 1 1 1 1 tagaturonate epimerase 5_3_exonuc PF01367.20 EWC45046.1 - 0.0071 16.9 0.0 0.023 15.3 0.0 1.9 2 1 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EWC45046.1 - 0.066 13.8 0.1 0.77 10.4 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix domain SMC_N PF02463.19 EWC45047.1 - 2.9e-20 72.7 19.4 9.1e-20 71.0 19.4 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EWC45047.1 - 9e-13 49.2 0.7 9e-13 49.2 0.7 4.8 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.6 EWC45047.1 - 2.9e-08 33.9 1.2 0.00034 20.5 0.0 3.2 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EWC45047.1 - 0.00078 19.6 0.1 0.006 16.8 0.0 2.4 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EWC45047.1 - 0.0062 16.3 0.2 0.016 14.9 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF5320 PF17253.2 EWC45047.1 - 8.6 7.5 7.5 7.6 7.7 0.1 4.4 4 1 1 5 5 5 0 Family of unknown function (DUF5320) fn3_2 PF16893.5 EWC45048.1 - 4.7e-40 135.6 0.2 8.2e-40 134.9 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EWC45048.1 - 1.3e-25 89.1 0.5 2.3e-25 88.2 0.5 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EWC45048.1 - 2.3e-14 53.1 0.0 4.1e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EWC45048.1 - 2e-09 37.7 0.0 3.3e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 EWC45048.1 - 4.1e-06 26.9 0.0 1.4e-05 25.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 EWC45048.1 - 0.00026 21.3 0.0 0.00062 20.1 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 EWC45048.1 - 0.00053 20.3 0.1 0.0017 18.7 0.1 1.8 1 1 0 1 1 1 1 Fibronectin type III domain fn3_4 PF16794.5 EWC45048.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Fibronectin-III type domain MAM33 PF02330.16 EWC45049.1 - 4.9e-73 245.6 1.8 9.6e-73 244.6 1.8 1.4 1 1 0 1 1 1 1 Mitochondrial glycoprotein Cys_Met_Meta_PP PF01053.20 EWC45050.1 - 4.9e-27 94.5 0.0 6.6e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EWC45050.1 - 0.00097 18.4 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Nrap PF03813.14 EWC45051.1 - 1.9e-27 96.2 0.0 5.4e-27 94.7 0.0 1.7 2 0 0 2 2 2 1 Nrap protein domain 1 Nrap_D5 PF17406.2 EWC45051.1 - 1.1e-26 93.5 0.0 2e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 EWC45051.1 - 1.9e-22 80.1 0.1 5.9e-22 78.4 0.0 1.8 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D4 PF17405.2 EWC45051.1 - 6.7e-22 77.9 0.0 1.3e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D2 PF17403.2 EWC45051.1 - 6.7e-12 45.4 0.3 9.3e-11 41.7 0.3 2.6 2 1 0 2 2 2 1 Nrap protein PAP/OAS-like domain YccV-like PF08755.11 EWC45053.1 - 2e-18 66.7 0.1 2.5e-18 66.4 0.1 1.1 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like DUF3665 PF12427.8 EWC45053.1 - 0.011 15.4 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Branched-chain amino acid aminotransferase Pkinase PF00069.25 EWC45054.1 - 6.2e-56 189.7 0.0 9.5e-51 172.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45054.1 - 5.3e-34 117.7 0.0 1.4e-31 109.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EWC45054.1 - 6.9e-07 28.9 0.0 2.3e-06 27.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EWC45054.1 - 0.0027 17.6 0.0 0.0051 16.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EWC45054.1 - 0.0051 15.7 0.0 0.03 13.1 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase SapB_1 PF05184.15 EWC45054.1 - 0.3 11.1 1.1 17 5.5 0.1 2.7 2 0 0 2 2 2 0 Saposin-like type B, region 1 PIG-X PF08320.12 EWC45055.1 - 2.9e-58 197.2 0.0 4.2e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 PyocinActivator PF11112.8 EWC45055.1 - 0.19 11.9 0.0 0.54 10.4 0.0 1.7 1 0 0 1 1 1 0 Pyocin activator protein PrtN Rubis-subs-bind PF09273.11 EWC45056.1 - 4.9e-08 33.7 0.1 8.6e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 EWC45056.1 - 2.3e-06 28.1 0.0 4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 SET domain P5-ATPase PF12409.8 EWC45057.1 - 6.3e-40 136.2 0.0 1.7e-39 134.8 0.0 1.8 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EWC45057.1 - 1.4e-28 99.7 0.2 5.3e-28 97.8 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EWC45057.1 - 6.8e-19 69.0 0.2 6.4e-09 36.4 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EWC45057.1 - 0.00041 20.0 0.0 0.0011 18.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EWC45057.1 - 0.0015 18.6 0.0 0.0033 17.5 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EWC45057.1 - 0.13 12.0 0.0 2 8.1 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase MrpF_PhaF PF04066.13 EWC45057.1 - 2.1 8.8 6.5 3.8 8.0 1.0 3.3 3 0 0 3 3 3 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) Radical_SAM_C PF16199.5 EWC45058.1 - 1.1e-32 111.8 0.0 2.6e-32 110.7 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EWC45058.1 - 8.6e-19 68.5 0.1 2.4e-18 67.1 0.1 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EWC45058.1 - 1.6e-09 38.0 0.0 4.3e-09 36.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC45058.1 - 5.1e-06 26.5 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Torus PF16131.5 EWC45059.1 - 3.4e-28 98.5 0.2 3.4e-28 98.5 0.2 2.0 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 EWC45059.1 - 3.8e-09 36.2 0.0 7.8e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EWC45059.1 - 0.002 18.1 0.0 0.0042 17.1 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf_CCCH_4 PF18345.1 EWC45059.1 - 0.0022 18.0 3.6 0.0046 17.0 2.8 2.0 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 EWC45059.1 - 0.022 14.6 3.5 0.043 13.7 3.5 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Alpha_Helical PF18489.1 EWC45059.1 - 0.07 13.3 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Alpha helical domain zf-CCCH_4 PF18044.1 EWC45059.1 - 0.24 11.3 5.4 0.5 10.2 5.4 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger Carla_C4 PF01623.17 EWC45059.1 - 0.93 9.5 3.6 0.7 9.9 1.2 2.0 3 0 0 3 3 3 0 Carlavirus putative nucleic acid binding protein tRNA-synt_2b PF00587.25 EWC45060.1 - 1.3e-34 119.7 0.0 2.1e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EWC45060.1 - 6.4e-16 58.5 2.1 6.4e-16 58.5 2.1 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain BAR PF03114.18 EWC45061.1 - 1e-62 211.9 3.6 1.2e-62 211.7 3.6 1.1 1 0 0 1 1 1 1 BAR domain CP12 PF02672.15 EWC45061.1 - 0.0081 16.9 0.1 0.063 14.0 0.0 2.5 2 1 1 3 3 3 1 CP12 domain DUF5610 PF18433.1 EWC45061.1 - 1.9 9.0 5.9 0.92 10.0 0.8 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5610) AMPK1_CBM PF16561.5 EWC45062.1 - 6e-31 106.5 0.0 1e-30 105.8 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EWC45062.1 - 1.7e-26 92.2 1.1 1.7e-26 92.2 1.1 2.8 3 0 0 3 3 3 1 5'-AMP-activated protein kinase beta subunit, interaction domain FA_desaturase PF00487.24 EWC45063.1 - 0.025 14.4 3.6 0.035 13.9 3.6 1.1 1 0 0 1 1 1 0 Fatty acid desaturase RseC_MucC PF04246.12 EWC45063.1 - 0.051 13.5 0.1 0.051 13.5 0.1 2.0 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC TB2_DP1_HVA22 PF03134.19 EWC45064.1 - 1.5e-24 85.7 8.0 2.4e-24 85.0 8.0 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family ATG101 PF07855.12 EWC45065.1 - 8.1e-26 90.9 0.9 8.9e-26 90.7 0.9 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 Peroxin-3 PF04882.12 EWC45066.1 - 1.5e-145 485.8 0.0 1e-144 483.0 0.0 1.8 1 1 0 1 1 1 1 Peroxin-3 DpaA_N PF16924.5 EWC45066.1 - 0.047 13.8 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain DKCLD PF08068.12 EWC45067.1 - 4.8e-32 109.8 0.2 7.5e-31 106.0 0.3 2.4 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EWC45067.1 - 6.2e-23 80.7 0.6 1.3e-22 79.7 0.6 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EWC45067.1 - 1.7e-22 79.1 1.9 3.6e-22 78.1 1.9 1.6 1 0 0 1 1 1 1 PUA domain TruB_N PF01509.18 EWC45067.1 - 1.9e-10 41.3 6.1 4e-05 24.0 0.0 3.9 2 1 1 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) UPF0113 PF03657.13 EWC45067.1 - 0.0008 19.6 0.0 0.0019 18.4 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain DER1 PF04511.15 EWC45068.1 - 6.2e-25 88.2 6.4 7.4e-25 88.0 6.4 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 EWC45068.1 - 0.0014 18.7 8.4 0.0037 17.3 8.4 1.8 1 1 0 1 1 1 1 Rhomboid family Sacchrp_dh_C PF16653.5 EWC45069.1 - 3.4e-93 312.6 0.0 1.5e-92 310.5 0.0 1.9 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EWC45069.1 - 1.8e-22 80.0 2.3 2.7e-22 79.4 2.3 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EWC45069.1 - 5.5e-05 23.1 2.7 0.00012 22.0 3.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 EWC45069.1 - 0.00012 22.1 0.3 0.00025 21.1 0.3 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 EWC45069.1 - 0.032 13.7 0.8 0.077 12.4 0.8 1.7 1 1 0 1 1 1 0 short chain dehydrogenase NAD_binding_3 PF03447.16 EWC45069.1 - 0.059 14.0 1.5 0.11 13.1 1.5 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain IlvN PF07991.12 EWC45069.1 - 0.097 12.2 0.8 0.76 9.3 0.8 2.2 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 EWC45069.1 - 0.12 12.8 0.4 0.22 12.0 0.4 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Kin17_mid PF10357.9 EWC45070.1 - 3.2e-53 179.0 1.0 5e-53 178.3 1.0 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EWC45070.1 - 0.00036 20.8 2.6 0.00069 19.9 2.6 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EWC45070.1 - 0.00087 19.5 1.2 0.0019 18.5 1.2 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EWC45070.1 - 0.026 14.9 0.3 0.026 14.9 0.3 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF2070 PF09843.9 EWC45071.1 - 8.5 4.5 8.4 12 4.1 8.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RFX_DNA_binding PF02257.15 EWC45073.1 - 1.2e-29 102.8 0.1 2.4e-29 101.8 0.1 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain 7TMR-HDED PF07697.11 EWC45073.1 - 0.081 13.0 0.1 0.5 10.4 0.1 2.1 1 1 0 1 1 1 0 7TM-HD extracellular DnaJ_C PF01556.18 EWC45074.1 - 7.2e-33 113.8 0.3 1.1e-32 113.2 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EWC45074.1 - 0.0085 16.2 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain UreF PF01730.16 EWC45075.1 - 5.8e-21 75.5 0.1 5.8e-21 75.5 0.1 1.8 2 0 0 2 2 2 1 UreF RRM_2 PF04059.12 EWC45076.1 - 1.3e-16 60.6 0.2 1.4e-13 50.9 0.2 2.5 1 1 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EWC45076.1 - 2.8e-06 27.0 0.0 0.02 14.7 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec15 PF04091.12 EWC45077.1 - 2.7e-103 345.7 0.8 2.7e-103 345.7 0.8 2.2 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like Vps54_N PF10475.9 EWC45077.1 - 0.0063 15.8 5.6 0.015 14.6 5.6 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Sec8_exocyst PF04048.14 EWC45077.1 - 0.011 15.6 3.6 0.036 14.0 3.6 1.9 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain COG5 PF10392.9 EWC45077.1 - 0.014 15.5 2.3 0.058 13.6 2.3 2.1 1 0 0 1 1 1 0 Golgi transport complex subunit 5 AcetDehyd-dimer PF09290.11 EWC45077.1 - 0.04 14.1 0.4 0.12 12.6 0.1 2.0 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation HsbA PF12296.8 EWC45077.1 - 0.1 13.0 1.9 0.23 11.9 1.9 1.5 1 0 0 1 1 1 0 Hydrophobic surface binding protein A COG2 PF06148.11 EWC45077.1 - 0.11 12.6 7.7 0.66 10.1 5.6 2.9 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CBFD_NFYB_HMF PF00808.23 EWC45078.1 - 3.8e-19 68.7 0.7 5.3e-19 68.3 0.7 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EWC45078.1 - 3.5e-14 53.3 0.2 6.5e-14 52.4 0.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EWC45078.1 - 0.087 13.2 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Fcf2 PF08698.11 EWC45079.1 - 3.3e-35 120.4 0.1 3.3e-35 120.4 0.1 2.1 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing Seryl_tRNA_N PF02403.22 EWC45079.1 - 0.018 15.3 1.2 0.018 15.3 1.2 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tti2 PF10521.9 EWC45079.1 - 0.48 9.9 1.4 3.3 7.2 0.1 2.0 2 0 0 2 2 2 0 Tti2 family D123 PF07065.14 EWC45080.1 - 1.2e-106 356.4 0.0 2.1e-106 355.6 0.0 1.4 2 0 0 2 2 2 1 D123 RAI1 PF08652.11 EWC45081.1 - 5e-26 90.7 0.0 9e-26 89.9 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease SelP_N PF04592.14 EWC45082.1 - 0.17 11.3 12.5 0.27 10.6 12.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF410 PF04190.13 EWC45083.1 - 6e-85 285.1 0.0 7.7e-85 284.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) SNAP PF14938.6 EWC45083.1 - 0.22 10.9 0.1 6.6 6.1 0.0 2.4 3 0 0 3 3 3 0 Soluble NSF attachment protein, SNAP MBOAT PF03062.19 EWC45084.1 - 1.1e-59 202.5 7.6 1.9e-59 201.8 7.6 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family tRNA-synt_1b PF00579.25 EWC45085.1 - 1.6e-67 227.9 0.0 3.1e-67 227.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_S10 PF00338.22 EWC45085.1 - 2.6e-26 91.7 0.0 8.8e-26 90.0 0.0 2.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e SOGA PF11365.8 EWC45085.1 - 0.62 11.2 7.1 2.8 9.1 0.9 2.9 1 1 1 2 2 2 0 Protein SOGA OmpH PF03938.14 EWC45085.1 - 0.85 9.9 9.7 2 8.7 3.6 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) AIM3 PF17096.5 EWC45087.1 - 1.2 10.1 6.2 0.23 12.4 0.8 2.5 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 EPL1 PF10513.9 EWC45088.1 - 4e-21 76.1 1.2 4e-21 76.1 1.2 2.1 2 1 0 2 2 2 1 Enhancer of polycomb-like PNP_UDP_1 PF01048.20 EWC45089.1 - 3.1e-51 173.9 0.1 3.8e-51 173.6 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Peptidase_M22 PF00814.25 EWC45090.1 - 1.9e-84 283.6 0.0 2.2e-84 283.3 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EWC45090.1 - 0.1 12.3 0.0 7.7 6.1 0.0 2.2 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus NIF PF03031.18 EWC45091.1 - 1.9e-16 60.2 0.0 2.9e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RRP36 PF06102.12 EWC45092.1 - 2.7e-51 173.9 29.4 2.7e-51 173.9 29.4 2.2 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 CENP-B_dimeris PF09026.10 EWC45092.1 - 4.9 7.6 16.1 0.075 13.4 6.7 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain BRF1 PF07741.13 EWC45093.1 - 0.036 14.4 0.3 0.3 11.5 0.2 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Ribosomal_S9 PF00380.19 EWC45094.1 - 2.7e-38 131.2 0.0 5e-38 130.3 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 C4bp_oligo PF18453.1 EWC45094.1 - 0.18 12.1 0.1 0.37 11.0 0.1 1.4 1 0 0 1 1 1 0 Oligomerization domain of C4b-binding protein alpha EF1G PF00647.19 EWC45095.1 - 1.2e-46 157.1 0.1 2.6e-46 156.1 0.1 1.6 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 EWC45095.1 - 1.9e-11 44.1 0.0 4.8e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EWC45095.1 - 4.2e-11 42.9 1.4 5.4e-11 42.6 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EWC45095.1 - 2.3e-07 30.7 0.1 8.2e-07 29.0 0.1 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EWC45095.1 - 3.6e-07 30.5 0.0 7.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EWC45095.1 - 0.0012 19.0 0.0 0.0028 17.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Endonuc-FokI_C PF09254.11 EWC45095.1 - 0.31 10.3 3.2 3.2 7.0 0.1 2.2 2 0 0 2 2 2 0 Restriction endonuclease FokI, C terminal Ribosomal_60s PF00428.19 EWC45095.1 - 2.1 9.0 10.5 14 6.4 11.2 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein EF-hand_1 PF00036.32 EWC45096.1 - 6.9e-26 87.8 13.7 7.8e-07 28.2 0.8 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EWC45096.1 - 3.7e-22 78.5 14.1 3.6e-13 49.7 1.8 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EWC45096.1 - 4.5e-20 69.8 6.9 4.6e-05 23.0 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EWC45096.1 - 3.5e-16 57.9 11.5 1.9e-05 24.0 0.5 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EWC45096.1 - 1.2e-12 47.5 15.5 0.00021 21.1 1.2 4.6 3 1 2 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EWC45096.1 - 1.4e-06 28.6 0.1 0.0027 18.0 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EWC45096.1 - 7.5e-05 22.6 8.7 0.017 15.1 0.5 3.9 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EWC45096.1 - 0.022 15.0 0.2 0.97 9.8 0.1 2.8 2 1 1 3 3 3 0 EF-hand domain HA2 PF04408.23 EWC45097.1 - 1.6e-26 92.7 0.6 5.2e-26 91.0 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EWC45097.1 - 1.1e-11 45.0 0.1 1.2e-08 35.2 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EWC45097.1 - 2.5e-09 37.4 0.0 1.2e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EWC45097.1 - 1.2e-08 34.9 0.4 5e-08 32.9 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EWC45097.1 - 6.9e-05 23.1 0.4 0.00039 20.7 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EWC45097.1 - 0.00037 20.9 0.1 0.0012 19.2 0.1 2.0 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC45097.1 - 0.00044 20.0 0.6 0.0019 17.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EWC45097.1 - 0.0044 17.5 10.5 0.0069 16.9 0.0 2.9 2 1 1 3 3 3 1 AAA domain ATPase PF06745.13 EWC45097.1 - 0.056 12.8 0.1 0.15 11.4 0.1 1.7 1 0 0 1 1 1 0 KaiC Pet127 PF08634.10 EWC45099.1 - 3.5e-88 295.6 3.2 4.8e-68 229.6 0.2 2.2 1 1 1 2 2 2 2 Mitochondrial protein Pet127 DUF2015 PF09435.10 EWC45101.1 - 8.2e-40 135.1 0.0 9.6e-40 134.9 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) PINIT PF14324.6 EWC45103.1 - 2.3e-33 115.6 0.1 4.3e-33 114.7 0.1 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EWC45103.1 - 2.5e-20 71.9 8.0 4.3e-20 71.2 8.0 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EWC45103.1 - 2.8e-06 27.0 4.1 5.9e-06 26.0 4.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 EWC45103.1 - 0.038 13.7 0.5 0.099 12.4 0.5 1.8 1 0 0 1 1 1 0 SAP domain zf-Sec23_Sec24 PF04810.15 EWC45103.1 - 0.43 10.7 4.7 0.55 10.3 3.3 1.9 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger CPBP PF02517.16 EWC45104.1 - 1.2e-15 57.6 9.4 1.2e-15 57.6 9.4 1.8 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease TRAPP PF04051.16 EWC45105.1 - 1.9e-09 37.4 0.0 2e-09 37.3 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF2378 PF09536.10 EWC45105.1 - 0.07 13.0 0.0 0.07 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2378) Ldh_1_N PF00056.23 EWC45106.1 - 3e-43 147.3 0.0 4.2e-43 146.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EWC45106.1 - 1.2e-40 139.2 0.0 1.5e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Semialdhyde_dh PF01118.24 EWC45106.1 - 0.032 14.7 0.1 0.25 11.8 0.0 2.3 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EWC45106.1 - 0.044 12.8 0.0 0.068 12.2 0.0 1.3 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 EWC45106.1 - 0.15 11.4 0.8 4.9 6.5 0.1 2.8 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Rep_fac_C PF08542.11 EWC45107.1 - 1.8e-25 89.1 0.0 6.4e-25 87.4 0.0 2.0 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EWC45107.1 - 1.8e-12 47.3 0.0 2.3e-09 37.3 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EWC45107.1 - 7.3e-12 45.9 0.0 1.4e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EWC45107.1 - 4.1e-07 30.1 0.0 1.7e-06 28.1 0.0 1.9 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EWC45107.1 - 8.4e-06 25.6 0.0 2e-05 24.4 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 EWC45107.1 - 1.3e-05 25.1 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EWC45107.1 - 1.5e-05 25.4 0.0 0.0015 18.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EWC45107.1 - 0.00011 22.5 0.2 0.11 12.7 0.2 3.1 2 1 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EWC45107.1 - 0.00021 21.2 0.0 0.00036 20.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EWC45107.1 - 0.00025 20.9 0.0 0.00038 20.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EWC45107.1 - 0.0027 17.6 0.0 0.0051 16.8 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain MeaB PF03308.16 EWC45107.1 - 0.0065 15.5 0.0 0.013 14.5 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_assoc_2 PF16193.5 EWC45107.1 - 0.0092 16.3 0.0 0.025 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain Mg_chelatase PF01078.21 EWC45107.1 - 0.011 15.1 0.1 0.13 11.7 0.1 2.1 1 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EWC45107.1 - 0.013 15.4 0.2 0.057 13.3 0.1 2.1 1 1 1 2 2 2 0 NTPase TniB PF05621.11 EWC45107.1 - 0.019 14.4 0.0 6.6 6.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 EWC45107.1 - 0.022 15.1 0.2 0.078 13.3 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EWC45107.1 - 0.027 14.3 0.0 0.046 13.5 0.0 1.3 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 EWC45107.1 - 0.062 12.7 0.0 0.1 12.0 0.0 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_25 PF13481.6 EWC45107.1 - 0.071 12.7 0.1 0.46 10.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EWC45107.1 - 0.071 12.8 0.0 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EWC45107.1 - 0.16 11.7 0.2 0.59 9.8 0.2 2.0 1 1 0 1 1 1 0 AAA domain Asp PF00026.23 EWC45108.1 - 2.9e-65 220.8 1.0 3.8e-65 220.4 1.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EWC45108.1 - 1.6e-10 41.5 0.1 1.3e-08 35.3 0.1 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EWC45108.1 - 1e-08 35.7 0.9 0.0014 19.2 0.0 3.6 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EWC45108.1 - 1.2e-05 25.7 0.0 0.01 16.3 0.0 3.5 3 1 0 3 3 3 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EWC45108.1 - 0.015 15.0 0.1 0.51 10.1 0.1 2.3 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Ribosomal_L28e PF01778.17 EWC45109.1 - 1.1e-28 100.3 0.5 1.6e-28 99.8 0.5 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family HemY_N PF07219.13 EWC45110.1 - 1.4 9.1 3.1 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 HemY protein N-terminus zf-Tim10_DDP PF02953.15 EWC45111.1 - 2.9e-17 62.1 6.8 9.7e-17 60.4 1.8 2.2 2 0 0 2 2 2 2 Tim10/DDP family zinc finger Gly_transf_sug PF04488.15 EWC45112.1 - 2.6e-18 66.5 0.0 7e-18 65.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EWC45112.1 - 0.016 14.6 0.5 0.18 11.1 0.1 2.0 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain cwf21 PF08312.12 EWC45113.1 - 5.2e-18 64.9 5.9 9.9e-18 64.0 5.9 1.5 1 0 0 1 1 1 1 cwf21 domain MeMO_Hyd_G PF02964.16 EWC45113.1 - 0.04 13.9 0.2 0.05 13.6 0.2 1.2 1 0 0 1 1 1 0 Methane monooxygenase, hydrolase gamma chain EccE PF11203.8 EWC45113.1 - 0.055 13.8 0.7 0.071 13.4 0.7 1.3 1 0 0 1 1 1 0 Putative type VII ESX secretion system translocon, EccE DUF4477 PF14780.6 EWC45114.1 - 0.11 12.0 3.1 0.59 9.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4477) Actin PF00022.19 EWC45115.1 - 6.9e-142 472.8 0.0 6.6e-141 469.6 0.0 2.3 1 1 0 1 1 1 1 Actin IGPD PF00475.18 EWC45116.1 - 4.8e-58 195.6 0.2 1.1e-57 194.4 0.1 1.5 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase GARS_A PF01071.19 EWC45117.1 - 9.3e-83 276.8 0.1 1.8e-82 275.8 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EWC45117.1 - 2.6e-34 117.9 0.2 9.1e-34 116.1 0.2 2.0 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EWC45117.1 - 4.1e-31 108.2 0.3 1.1e-30 106.8 0.0 1.8 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EWC45117.1 - 4.5e-24 84.5 0.8 1.8e-23 82.6 0.2 2.3 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EWC45117.1 - 7.3e-15 55.4 2.1 2.1e-14 54.0 2.1 1.8 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 EWC45117.1 - 0.00044 20.3 0.1 0.0017 18.4 0.0 2.1 2 1 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.22 EWC45117.1 - 0.00076 19.1 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 EWC45117.1 - 0.0053 16.4 0.1 0.02 14.5 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.10 EWC45117.1 - 0.041 13.4 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain CPSase_L_D2 PF02786.17 EWC45117.1 - 0.062 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain SMI1_KNR4 PF09346.10 EWC45118.1 - 7.7e-31 107.2 0.0 1.5e-30 106.3 0.0 1.5 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) EamA PF00892.20 EWC45119.1 - 8.1e-05 22.8 8.5 8.1e-05 22.8 8.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family U83 PF17465.2 EWC45119.1 - 0.06 13.5 0.1 0.16 12.1 0.0 1.7 1 1 0 1 1 1 0 Chemokine-like protein, HHV-6 U83 gene product TPT PF03151.16 EWC45119.1 - 0.073 12.4 20.3 0.3 10.4 20.3 1.8 1 1 0 1 1 1 0 Triose-phosphate Transporter family PHO4 PF01384.20 EWC45119.1 - 2.6 7.0 19.3 0.096 11.7 6.7 2.2 1 1 0 2 2 2 0 Phosphate transporter family NOPS PF08075.11 EWC45120.1 - 0.32 11.2 1.4 0.41 10.9 0.4 1.7 1 1 1 2 2 2 0 NOPS (NUC059) domain PDT PF00800.18 EWC45121.1 - 4.4e-60 202.6 0.0 5.5e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EWC45121.1 - 1.4e-08 34.4 0.0 3.5e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 ACT domain eRF1_2 PF03464.15 EWC45122.1 - 3.8e-48 163.2 0.7 5.4e-48 162.7 0.1 1.6 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.15 EWC45122.1 - 4.6e-39 133.4 0.2 1.1e-38 132.2 0.2 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EWC45122.1 - 5.3e-21 75.0 0.0 9.2e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EWC45122.1 - 6.6e-10 39.4 0.0 1.2e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EWC45122.1 - 1.1e-09 38.6 0.1 1.9e-09 37.9 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Rad50_zn_hook PF04423.14 EWC45122.1 - 0.057 13.3 0.1 12 5.8 0.0 3.1 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF3572 PF12096.8 EWC45123.1 - 0.11 12.7 0.1 0.16 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) Pet100 PF09803.9 EWC45124.1 - 5.6e-22 78.1 0.1 7.4e-22 77.7 0.1 1.1 1 0 0 1 1 1 1 Pet100 Ras PF00071.22 EWC45125.1 - 1.5e-48 164.4 0.0 1.8e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC45125.1 - 8.4e-26 90.5 0.0 1.2e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC45125.1 - 5.9e-10 38.9 0.0 8.6e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EWC45125.1 - 2.5e-05 23.8 0.1 4e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EWC45125.1 - 3.4e-05 23.3 0.0 4.8e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EWC45125.1 - 0.00043 20.4 0.0 0.00066 19.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 EWC45125.1 - 0.004 16.6 0.0 0.006 16.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein PduV-EutP PF10662.9 EWC45125.1 - 0.0063 16.3 0.0 0.21 11.3 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EWC45125.1 - 0.008 16.0 0.0 0.81 9.4 0.0 2.2 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein ADH_zinc_N PF00107.26 EWC45125.1 - 0.025 14.6 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase AAA_22 PF13401.6 EWC45125.1 - 0.026 14.8 0.0 0.044 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EWC45125.1 - 0.028 14.8 0.1 0.038 14.4 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EWC45125.1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EWC45125.1 - 0.1 11.8 0.1 0.43 9.7 0.0 1.7 1 1 1 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 EWC45125.1 - 0.15 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_35 PF14516.6 EWC45125.1 - 0.22 10.3 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain Abhydrolase_1 PF00561.20 EWC45126.1 - 1.7e-14 54.1 0.0 9.6e-11 41.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EWC45126.1 - 1.9e-10 41.8 0.2 4.3e-10 40.6 0.2 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC45126.1 - 4.2e-05 22.9 0.1 0.00029 20.2 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 RNA_pol_L_2 PF13656.6 EWC45127.1 - 2.7e-33 113.5 0.0 3.6e-33 113.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EWC45127.1 - 3.2e-16 58.5 0.0 4.3e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Vps51 PF08700.11 EWC45128.1 - 1.6e-10 40.9 0.2 8.4e-10 38.6 0.1 2.3 2 0 0 2 2 2 1 Vps51/Vps67 COG5 PF10392.9 EWC45128.1 - 0.24 11.6 4.7 0.16 12.1 0.3 2.9 3 0 0 3 3 3 0 Golgi transport complex subunit 5 COG2 PF06148.11 EWC45128.1 - 0.45 10.6 5.6 0.11 12.5 0.9 2.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Tyr-DNA_phospho PF06087.12 EWC45129.1 - 1.9e-80 270.9 0.0 3.1e-80 270.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EWC45129.1 - 0.00067 19.5 0.0 0.0019 18.1 0.0 1.7 1 0 0 1 1 1 1 PLD-like domain Tma16 PF11176.8 EWC45129.1 - 0.014 15.2 0.3 0.03 14.2 0.3 1.5 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Gti1_Pac2 PF09729.9 EWC45130.1 - 3.3e-50 170.7 0.0 6.4e-50 169.8 0.0 1.5 1 0 0 1 1 1 1 Gti1/Pac2 family GIDA PF01134.22 EWC45131.1 - 3.2e-154 513.8 0.0 3.9e-154 513.5 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EWC45131.1 - 1.2e-65 221.7 0.0 1.6e-65 221.2 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 EWC45131.1 - 6.3e-07 28.9 0.4 2.6e-06 26.9 0.5 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EWC45131.1 - 6.4e-07 29.1 0.1 9.4e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EWC45131.1 - 2.7e-05 23.5 3.6 6.2e-05 22.3 3.6 1.6 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EWC45131.1 - 0.022 14.0 0.4 0.038 13.2 0.4 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 EWC45131.1 - 0.029 14.9 0.4 0.067 13.8 0.4 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EWC45131.1 - 0.036 12.8 5.6 0.14 10.9 0.9 2.5 3 0 0 3 3 3 0 HI0933-like protein AlaDh_PNT_C PF01262.21 EWC45131.1 - 0.17 11.1 1.0 0.37 10.0 1.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF1640 PF07798.11 EWC45132.1 - 1.8e-38 132.3 5.2 2.3e-38 132.0 5.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Asp PF00026.23 EWC45133.1 - 4.1e-110 368.1 0.3 6.2e-110 367.5 0.3 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EWC45133.1 - 3.6e-14 53.4 3.4 6e-12 46.2 2.1 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EWC45133.1 - 1.3e-05 25.1 0.0 0.00016 21.5 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EWC45133.1 - 0.00057 20.5 0.1 3 8.6 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EWC45133.1 - 0.00067 20.2 0.0 2.1 9.0 0.0 3.0 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease Pkinase PF00069.25 EWC45134.1 - 1.7e-66 224.3 0.0 2.4e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45134.1 - 4.3e-46 157.3 0.0 7e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC45134.1 - 3.9e-09 36.2 0.0 2.6e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EWC45134.1 - 0.037 13.4 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EWC45134.1 - 0.049 12.4 0.0 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EWC45134.1 - 0.066 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Dioxygenase_N PF04444.14 EWC45134.1 - 0.073 12.9 0.2 0.49 10.3 0.0 2.4 2 0 0 2 2 2 0 Catechol dioxygenase N terminus A1_Propeptide PF07966.12 EWC45134.1 - 0.18 11.7 0.0 0.44 10.5 0.0 1.7 1 0 0 1 1 1 0 A1 Propeptide Yippee-Mis18 PF03226.14 EWC45135.1 - 2.9e-08 33.9 0.0 5e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EWC45135.1 - 0.0048 17.1 0.2 0.0091 16.2 0.2 1.5 1 0 0 1 1 1 1 C-terminal domain of RIG-I CpXC PF14353.6 EWC45135.1 - 0.027 14.5 1.1 0.097 12.7 0.3 2.4 2 1 0 2 2 2 0 CpXC protein zinc_ribbon_10 PF10058.9 EWC45135.1 - 0.15 11.8 0.4 0.78 9.5 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Spc7 PF08317.11 EWC45135.1 - 1 8.2 9.0 1.5 7.7 9.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3818 PF12825.7 EWC45136.1 - 1.9e-129 431.5 4.1 2.8e-129 431.0 4.1 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EWC45136.1 - 8e-40 135.8 1.7 1.6e-39 134.9 1.7 1.5 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EWC45136.1 - 0.0035 17.3 1.5 0.052 13.5 1.5 2.7 1 1 0 1 1 1 1 PX domain TetR_C_17 PF17922.1 EWC45136.1 - 0.11 12.7 0.0 0.81 9.8 0.0 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PWI PF01480.17 EWC45137.1 - 2.5e-26 91.8 0.7 4.6e-26 90.9 0.7 1.5 1 0 0 1 1 1 1 PWI domain HSCB_C PF07743.13 EWC45137.1 - 2.5e-12 47.1 0.3 2.5e-12 47.1 0.3 2.4 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DUF755 PF05501.11 EWC45137.1 - 0.0015 18.8 10.1 0.0025 18.1 10.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF755) DnaJ PF00226.31 EWC45137.1 - 0.0039 17.3 0.0 0.0092 16.1 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Rrn6 PF10214.9 EWC45137.1 - 0.0072 14.9 7.7 0.01 14.4 7.7 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Pex14_N PF04695.13 EWC45137.1 - 0.22 12.2 10.5 0.38 11.4 10.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region U79_P34 PF03064.16 EWC45137.1 - 0.22 10.8 3.7 0.34 10.2 3.7 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Herpes_pp85 PF04637.12 EWC45137.1 - 0.25 9.7 2.4 0.48 8.8 2.4 1.4 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Presenilin PF01080.17 EWC45137.1 - 0.39 9.4 1.8 0.5 9.1 1.8 1.1 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 EWC45137.1 - 0.78 6.8 3.3 1 6.4 3.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AIM3 PF17096.5 EWC45137.1 - 7.7 7.5 14.8 3.5 8.6 10.6 2.2 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 HEAT_2 PF13646.6 EWC45138.1 - 8.2e-05 22.9 0.2 0.00014 22.2 0.2 1.3 1 0 0 1 1 1 1 HEAT repeats Nitroreductase PF00881.24 EWC45138.1 - 0.055 13.5 0.1 0.092 12.8 0.1 1.3 1 0 0 1 1 1 0 Nitroreductase family Prenyltransf PF01255.19 EWC45139.1 - 9.7e-07 28.5 0.0 0.00014 21.5 0.0 2.2 2 0 0 2 2 2 2 Putative undecaprenyl diphosphate synthase DUF5099 PF17025.5 EWC45139.1 - 0.01 16.3 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5099) Sybindin PF04099.12 EWC45140.1 - 2.4e-45 154.0 0.0 1.7e-44 151.2 0.0 1.9 1 1 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EWC45140.1 - 7e-09 35.9 0.0 7.9e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region VirE1 PF12189.8 EWC45140.1 - 0.02 15.0 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 Single-strand DNA-binding protein RNA_pol_Rpb4 PF03874.16 EWC45141.1 - 1.3e-22 80.4 0.6 1.7e-22 80.0 0.6 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Cut8 PF08559.10 EWC45141.1 - 0.029 14.0 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 Cut8, nuclear proteasome tether protein MIF4G_like_2 PF09090.11 EWC45141.1 - 0.061 12.8 0.6 0.11 11.9 0.2 1.6 2 0 0 2 2 2 0 MIF4G like ERO1 PF04137.15 EWC45142.1 - 2e-130 435.1 0.0 2.6e-130 434.7 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Haspin_kinase PF12330.8 EWC45143.1 - 1.5e-40 139.3 0.0 2.3e-40 138.7 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EWC45143.1 - 0.00037 20.5 0.1 0.011 15.6 0.2 2.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 EWC45143.1 - 0.00072 19.0 0.0 0.067 12.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain TPT PF03151.16 EWC45144.1 - 2.2e-36 125.7 15.3 2.8e-36 125.4 15.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EWC45144.1 - 6.3e-10 38.7 19.1 1.4e-09 37.6 19.1 1.5 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EWC45144.1 - 3.4e-07 30.5 28.1 0.00027 21.1 11.1 2.3 2 0 0 2 2 2 2 EamA-like transporter family GTP_EFTU PF00009.27 EWC45145.1 - 4.2e-46 157.0 0.0 7.7e-46 156.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EWC45145.1 - 9.4e-38 129.5 7.3 1.6e-37 128.8 7.3 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EWC45145.1 - 3.3e-25 88.2 0.0 6.7e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EWC45145.1 - 4.3e-19 68.3 0.0 1.1e-18 67.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EWC45145.1 - 1.2e-12 48.0 0.1 3.1e-12 46.7 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EWC45145.1 - 2.1e-07 30.9 0.0 4.6e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EWC45145.1 - 0.00031 20.8 0.0 0.00057 19.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EWC45145.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Septin FeS_assembly_P PF01883.19 EWC45146.1 - 4.7e-08 33.1 0.0 2.9e-07 30.6 0.0 2.1 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein Fungal_trans PF04082.18 EWC45147.1 - 1.7e-07 30.5 0.3 2.7e-07 29.9 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC45147.1 - 8.9e-07 28.9 9.4 1.8e-06 28.0 9.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Thiolase_N PF00108.23 EWC45148.1 - 4.5e-95 317.9 1.0 7.7e-95 317.2 1.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EWC45148.1 - 9.5e-44 148.0 1.1 1.8e-43 147.1 1.1 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EWC45148.1 - 0.0001 22.0 1.0 0.00025 20.7 0.5 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EWC45148.1 - 0.21 11.5 5.5 0.64 9.9 0.2 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GNAT_acetyltr_2 PF13718.6 EWC45149.1 - 8e-99 329.6 0.0 1.5e-98 328.8 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EWC45149.1 - 1.8e-90 302.8 0.4 3.1e-90 302.0 0.4 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EWC45149.1 - 9.2e-65 217.8 2.1 4.4e-64 215.6 0.0 3.0 3 1 0 3 3 3 1 Helicase DUF1726 PF08351.11 EWC45149.1 - 2e-34 117.4 0.3 7.2e-34 115.6 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_19 PF13245.6 EWC45149.1 - 0.0011 19.4 0.4 0.27 11.6 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EWC45149.1 - 0.0015 18.3 2.4 0.04 13.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EWC45149.1 - 0.0089 16.3 0.5 0.49 10.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain Acetyltransf_1 PF00583.25 EWC45149.1 - 0.011 16.0 0.0 0.34 11.1 0.0 2.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family GHMP_kinases_N PF00288.26 EWC45149.1 - 0.053 13.8 3.0 0.85 9.9 0.3 2.7 2 0 0 2 2 2 0 GHMP kinases N terminal domain LAMTOR5 PF16672.5 EWC45150.1 - 0.069 13.1 2.0 0.62 10.0 0.0 2.3 2 0 0 2 2 2 0 Ragulator complex protein LAMTOR5 zf-B_box PF00643.24 EWC45150.1 - 0.14 12.4 7.1 0.2 11.8 7.1 1.2 1 0 0 1 1 1 0 B-box zinc finger zf-HIT PF04438.16 EWC45150.1 - 3 7.8 7.0 4.5 7.2 7.0 1.2 1 0 0 1 1 1 0 HIT zinc finger DUF2401 PF10287.9 EWC45151.1 - 1e-69 234.6 0.5 1.7e-69 234.0 0.5 1.2 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EWC45151.1 - 6.8e-16 58.4 0.1 6.8e-16 58.4 0.1 2.8 3 0 0 3 3 3 1 Glycine-rich protein domain (DUF2403) RyR PF02026.16 EWC45152.1 - 1.7e-13 50.6 0.1 3.9e-10 39.8 0.0 2.1 2 0 0 2 2 2 2 RyR domain CorA PF01544.18 EWC45153.1 - 0.0044 16.4 11.7 0.015 14.6 11.7 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EWC45153.1 - 0.043 12.6 0.1 0.061 12.1 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PIG-Y PF15159.6 EWC45153.1 - 0.044 14.7 4.5 0.095 13.6 4.5 1.6 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y EMP70 PF02990.16 EWC45153.1 - 0.074 11.7 0.7 0.11 11.2 0.7 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 DUF3827 PF12877.7 EWC45153.1 - 0.12 10.7 0.2 0.21 9.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) RyR PF02026.16 EWC45154.1 - 1.3e-09 38.1 1.1 9.3e-05 22.5 0.4 2.4 2 0 0 2 2 2 2 RyR domain HET PF06985.11 EWC45155.1 - 4.3e-33 114.7 0.1 6.8e-33 114.1 0.1 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) LMBR1 PF04791.16 EWC45156.1 - 1.6e-10 40.6 23.6 3.5e-10 39.4 9.0 2.4 3 0 0 3 3 3 2 LMBR1-like membrane protein Gaa1 PF04114.14 EWC45156.1 - 1.9 7.4 13.7 2.2 7.2 6.3 3.2 2 1 1 3 3 3 0 Gaa1-like, GPI transamidase component CPSF_A PF03178.15 EWC45157.1 - 9.5e-83 278.2 0.0 2.6e-82 276.7 0.0 1.8 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 EWC45157.1 - 1.9e-20 73.0 0.0 4.4e-20 71.8 0.0 1.6 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term F_actin_cap_B PF01115.17 EWC45158.1 - 5.8e-110 366.6 0.0 6.7e-110 366.3 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 EWC45158.1 - 0.00058 19.4 0.1 0.0031 17.0 0.0 2.1 1 1 1 2 2 2 2 F-actin capping protein alpha subunit TFIIS_M PF07500.14 EWC45159.1 - 1.2e-33 116.0 1.3 2.6e-33 114.8 0.7 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EWC45159.1 - 7.6e-19 67.3 3.8 1.2e-18 66.6 3.8 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EWC45159.1 - 2.7e-14 52.9 1.0 1e-13 51.0 0.6 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain CaM_bdg_C0 PF10562.9 EWC45159.1 - 0.12 12.5 0.2 0.36 10.9 0.2 1.8 1 0 0 1 1 1 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit DNA_RNApol_7kD PF03604.13 EWC45159.1 - 0.79 9.5 6.1 1.7 8.4 0.1 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Methyltransf_28 PF02636.17 EWC45160.1 - 1.4e-35 123.2 0.0 2.1e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 EWC45160.1 - 0.069 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EWC45160.1 - 0.12 13.1 0.0 0.34 11.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PALP PF00291.25 EWC45161.1 - 3.3e-64 217.1 0.1 4.1e-64 216.8 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF2613 PF11021.8 EWC45161.1 - 0.31 11.2 3.5 4 7.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Scm3 PF10384.9 EWC45162.1 - 8.6e-20 70.2 0.2 1.7e-19 69.3 0.2 1.5 1 0 0 1 1 1 1 Centromere protein Scm3 CorA PF01544.18 EWC45163.1 - 4.2e-05 23.0 0.0 7.8e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF1512 PF07431.12 EWC45163.1 - 0.22 10.5 1.2 0.38 9.7 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) Aldolase_II PF00596.21 EWC45164.1 - 1.3e-47 162.1 0.1 1.6e-47 161.9 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Calreticulin PF00262.18 EWC45165.1 - 2.3e-165 549.9 10.2 3.2e-165 549.4 10.2 1.2 1 0 0 1 1 1 1 Calreticulin family Ribosomal_60s PF00428.19 EWC45165.1 - 0.022 15.3 1.5 0.022 15.3 1.5 3.3 3 1 1 4 4 4 0 60s Acidic ribosomal protein Aldedh PF00171.22 EWC45166.1 - 2.9e-126 421.7 0.8 6e-125 417.4 0.8 2.0 1 1 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EWC45166.1 - 0.078 12.0 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) VMA21 PF09446.10 EWC45167.1 - 1.1e-10 41.4 7.4 1.7e-10 40.8 7.4 1.3 1 0 0 1 1 1 1 VMA21-like domain SNF2_N PF00176.23 EWC45168.1 - 1.8e-48 165.1 0.0 4.1e-48 163.9 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC45168.1 - 1.8e-15 57.2 0.0 7.4e-15 55.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC45168.1 - 5.3e-08 33.0 0.0 1.6e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HIGH_NTase1_ass PF16581.5 EWC45168.1 - 0.0006 19.9 0.0 0.0015 18.6 0.0 1.6 1 0 0 1 1 1 1 Cytidyltransferase-related C-terminal region ERCC3_RAD25_C PF16203.5 EWC45168.1 - 0.0014 17.9 0.7 0.0022 17.3 0.0 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase MFS_1 PF07690.16 EWC45169.1 - 2.1e-46 158.5 30.3 2.8e-40 138.4 25.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC45169.1 - 3.3e-08 32.8 29.0 0.00067 18.6 3.8 4.0 3 1 0 4 4 4 3 Sugar (and other) transporter OATP PF03137.20 EWC45169.1 - 0.37 9.0 11.2 0.024 13.0 1.0 2.9 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF624 PF04854.14 EWC45169.1 - 5.3 7.2 13.2 27 5.0 0.0 4.6 4 1 0 4 4 4 0 Protein of unknown function, DUF624 Abhydrolase_6 PF12697.7 EWC45170.1 - 5.9e-23 82.6 4.0 5.9e-23 82.6 4.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EWC45170.1 - 1.5e-10 41.1 0.1 5.3e-10 39.4 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC45170.1 - 1.4e-07 31.0 0.1 2.2e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EWC45170.1 - 8.8e-05 22.7 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 EWC45170.1 - 0.11 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF676 PF05057.14 EWC45170.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF3602 PF12223.8 EWC45171.1 - 2.6e-14 53.6 28.0 2.8e-10 40.6 8.4 3.9 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Rotamase_3 PF13616.6 EWC45173.1 - 2.2e-18 66.9 0.0 4.4e-18 65.9 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EWC45173.1 - 1.4e-15 58.0 0.0 3.1e-15 56.9 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EWC45173.1 - 0.0028 18.5 0.0 0.0058 17.5 0.0 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Helicase_C PF00271.31 EWC45174.1 - 9.6e-22 77.4 0.0 2.4e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC45174.1 - 6.7e-21 75.0 0.0 1.7e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EWC45174.1 - 1e-16 61.2 0.0 4.2e-16 59.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EWC45174.1 - 0.012 15.3 0.0 0.03 14.0 0.0 1.7 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_22 PF13401.6 EWC45174.1 - 0.026 14.8 0.0 0.07 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Apolipoprotein PF01442.18 EWC45175.1 - 4e-07 30.1 5.0 0.0048 16.8 0.2 2.5 2 0 0 2 2 2 2 Apolipoprotein A1/A4/E domain ApoLp-III PF07464.11 EWC45175.1 - 1.2e-06 28.6 26.7 0.0061 16.7 5.7 3.9 1 1 2 3 3 3 2 Apolipophorin-III precursor (apoLp-III) Dynamin_M PF01031.20 EWC45175.1 - 0.00022 20.5 1.6 0.006 15.8 0.1 2.3 2 0 0 2 2 2 1 Dynamin central region Mitofilin PF09731.9 EWC45175.1 - 0.0015 17.5 13.3 0.0021 17.0 13.3 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Prominin PF05478.11 EWC45175.1 - 0.0089 14.0 8.9 0.011 13.8 7.8 1.6 1 1 0 1 1 1 1 Prominin DUF4618 PF15397.6 EWC45175.1 - 0.012 15.0 6.3 0.11 11.9 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) YtxH PF12732.7 EWC45175.1 - 0.021 15.4 40.9 3e+02 2.0 6.5 6.4 2 2 1 3 3 2 0 YtxH-like protein DUF883 PF05957.13 EWC45175.1 - 0.024 15.2 17.0 0.97 10.1 0.7 5.2 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF883) ISG65-75 PF11727.8 EWC45175.1 - 0.048 12.9 27.1 0.15 11.3 5.7 3.9 2 2 1 4 4 4 0 Invariant surface glycoprotein Baculo_PEP_C PF04513.12 EWC45175.1 - 0.077 13.0 13.4 2.1 8.4 1.3 3.4 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2884 PF11101.8 EWC45175.1 - 0.18 11.3 18.0 1.9 7.9 0.5 3.6 1 1 1 3 3 3 0 Protein of unknown function (DUF2884) HisKA_3 PF07730.13 EWC45175.1 - 0.21 12.1 1.1 16 6.1 0.0 3.6 4 2 0 4 4 3 0 Histidine kinase COG5 PF10392.9 EWC45175.1 - 0.21 11.8 0.8 5.7 7.1 0.1 2.6 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Tweety PF04906.13 EWC45175.1 - 0.28 9.8 9.2 0.69 8.5 0.3 3.0 1 1 2 3 3 3 0 Tweety EDR1 PF14381.6 EWC45175.1 - 0.43 10.3 6.7 3.3 7.4 0.1 3.1 1 1 1 3 3 3 0 Ethylene-responsive protein kinase Le-CTR1 HSBP1 PF06825.12 EWC45175.1 - 0.6 10.0 2.7 4.3 7.3 0.2 2.8 3 0 0 3 3 3 0 Heat shock factor binding protein 1 Topo-VIb_trans PF09239.11 EWC45175.1 - 0.73 9.6 4.8 7.6 6.3 0.2 3.2 3 0 0 3 3 3 0 Topoisomerase VI B subunit, transducer DUF5082 PF16888.5 EWC45175.1 - 0.8 10.0 14.5 5.3 7.3 3.7 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) B12-binding_2 PF02607.17 EWC45175.1 - 1 9.8 4.8 16 6.0 0.1 3.2 3 0 0 3 3 3 0 B12 binding domain DUF885 PF05960.11 EWC45175.1 - 1.2 8.7 3.1 12 5.4 0.1 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF885) HIP1_clath_bdg PF16515.5 EWC45175.1 - 1.2 9.7 5.9 3.7 8.2 0.3 3.3 2 2 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 LXG PF04740.12 EWC45175.1 - 1.9 8.2 16.3 0.33 10.6 1.2 3.8 1 1 1 3 3 3 0 LXG domain of WXG superfamily ArAE_1_C PF11728.8 EWC45175.1 - 2.1 8.3 5.4 4.3 7.3 1.2 3.0 2 1 0 2 2 2 0 Putative aromatic acid exporter C-terminal domain DUF1664 PF07889.12 EWC45175.1 - 3.7 7.6 23.8 2.9 8.0 2.0 4.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) V-ATPase_G_2 PF16999.5 EWC45175.1 - 3.8 8.0 8.6 1.2 9.6 0.7 3.2 2 2 1 3 3 3 0 Vacuolar (H+)-ATPase G subunit Mis12 PF05859.12 EWC45175.1 - 5.5 7.1 8.3 7.2 6.7 0.3 3.4 3 1 0 3 3 3 0 Mis12 protein AAA PF00004.29 EWC45177.1 - 1.9e-17 64.0 0.0 3.8e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EWC45177.1 - 2.4e-16 59.9 0.0 5.9e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EWC45177.1 - 8.8e-15 54.8 0.0 3.1e-14 53.1 0.0 1.9 2 1 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EWC45177.1 - 1.1e-08 35.3 0.0 2.3e-08 34.2 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EWC45177.1 - 1.6e-05 25.1 0.2 7e-05 23.1 0.1 2.1 1 1 0 1 1 1 1 AAA C-terminal domain RuvB_N PF05496.12 EWC45177.1 - 2.1e-05 24.3 0.0 9.6e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EWC45177.1 - 2.9e-05 24.4 0.0 0.00035 20.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EWC45177.1 - 3e-05 24.5 0.0 0.00065 20.1 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 EWC45177.1 - 3.3e-05 23.8 0.1 8.3e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC45177.1 - 0.00014 21.7 0.0 0.00077 19.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EWC45177.1 - 0.00018 21.5 0.0 0.00046 20.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain DUF815 PF05673.13 EWC45177.1 - 0.00046 19.4 0.0 0.00074 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EWC45177.1 - 0.00068 20.0 0.0 0.0031 17.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EWC45177.1 - 0.00075 18.9 0.0 0.013 14.9 0.0 2.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EWC45177.1 - 0.0011 18.7 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EWC45177.1 - 0.0015 18.5 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 EWC45177.1 - 0.0041 16.4 0.0 0.0071 15.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EWC45177.1 - 0.0053 16.3 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region ResIII PF04851.15 EWC45177.1 - 0.011 15.7 0.0 0.078 13.0 0.0 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 EWC45177.1 - 0.023 15.3 0.0 0.06 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.13 EWC45177.1 - 0.024 14.4 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_28 PF13521.6 EWC45177.1 - 0.033 14.5 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EWC45177.1 - 0.094 13.1 0.0 0.23 11.9 0.0 1.8 1 1 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EWC45177.1 - 0.095 12.6 0.0 0.53 10.2 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EWC45177.1 - 0.11 12.2 0.1 0.84 9.4 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_33 PF13671.6 EWC45177.1 - 0.13 12.4 0.0 0.45 10.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EWC45177.1 - 0.13 11.7 0.0 3.2 7.1 0.0 2.5 3 0 0 3 3 3 0 Bacterial TniB protein DUF1746 PF08508.10 EWC45178.1 - 5.2e-39 133.2 1.9 8.2e-39 132.5 1.9 1.3 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) DUF1980 PF09323.10 EWC45178.1 - 0.017 15.0 0.3 0.034 14.0 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) SRP14 PF02290.15 EWC45179.1 - 3.2e-23 81.9 0.0 2.2e-22 79.2 0.0 2.0 1 1 0 1 1 1 1 Signal recognition particle 14kD protein Amino_oxidase PF01593.24 EWC45180.1 - 2e-86 291.1 0.1 1.2e-73 249.0 0.0 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase SWIRM PF04433.17 EWC45180.1 - 2.7e-14 53.2 0.0 8.9e-14 51.6 0.0 1.9 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 EWC45180.1 - 8.5e-09 35.5 0.4 1.8e-08 34.5 0.4 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EWC45180.1 - 0.00023 20.8 2.9 0.00062 19.5 3.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase HMG_box PF00505.19 EWC45180.1 - 0.00042 20.7 1.1 0.0014 19.0 1.1 2.0 1 1 0 1 1 1 1 HMG (high mobility group) box NAD_binding_9 PF13454.6 EWC45180.1 - 0.0018 18.3 0.2 0.12 12.4 0.2 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EWC45180.1 - 0.0089 15.3 0.1 0.18 11.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EWC45180.1 - 0.17 10.9 0.7 15 4.6 0.4 2.6 3 0 0 3 3 3 0 FAD binding domain Fasciclin PF02469.22 EWC45181.1 - 0.0015 18.7 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain TFA2_Winged_2 PF18121.1 EWC45181.1 - 0.12 12.1 0.0 1.8 8.3 0.0 2.2 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 Pkinase PF00069.25 EWC45182.1 - 1.3e-64 218.1 0.1 1.5e-64 217.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45182.1 - 1.9e-17 63.4 0.0 2.7e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC45182.1 - 1.3e-07 31.8 0.0 7.2e-06 26.1 0.0 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EWC45182.1 - 0.0045 15.8 0.0 0.011 14.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EWC45182.1 - 0.022 14.1 0.2 0.042 13.2 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EWC45182.1 - 0.03 13.9 0.7 0.051 13.2 0.1 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kinase-like PF14531.6 EWC45182.1 - 0.03 13.7 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pal1 PF08316.11 EWC45184.1 - 5.7e-10 40.1 0.3 2.7e-09 37.9 0.1 2.3 2 0 0 2 2 2 1 Pal1 cell morphology protein HVSL PF09749.9 EWC45186.1 - 7.4e-75 251.5 0.0 9.6e-75 251.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein CDP-OH_P_transf PF01066.21 EWC45186.1 - 2.4e-14 53.9 0.3 2.4e-14 53.9 0.3 2.2 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase Peptidase_S8 PF00082.22 EWC45187.1 - 5.3e-36 124.4 2.6 5.3e-36 124.4 2.6 2.0 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 EWC45187.1 - 5.9e-27 93.5 1.1 5.9e-27 93.5 1.1 1.7 2 0 0 2 2 2 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 EWC45187.1 - 0.00011 22.9 1.5 0.00024 21.8 1.5 1.6 1 0 0 1 1 1 1 Peptidase S8 pro-domain stn_TNFRSF12A PF12191.8 EWC45187.1 - 0.05 13.8 1.3 0.12 12.6 0.3 2.0 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain SOG2 PF10428.9 EWC45187.1 - 6.4 5.9 8.6 9.2 5.3 8.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MFS_2 PF13347.6 EWC45189.1 - 7.5e-12 44.5 8.4 7.5e-12 44.5 8.4 2.8 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 EWC45189.1 - 0.00012 21.1 0.0 0.00085 18.3 0.1 2.1 2 0 0 2 2 2 1 MFS_1 like family G6PD_C PF02781.16 EWC45190.1 - 1.9e-113 378.5 0.0 3.4e-113 377.7 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EWC45190.1 - 1.6e-60 204.8 0.0 2.5e-60 204.1 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Lipoprotein_6 PF01441.19 EWC45191.1 - 0.0028 17.7 2.3 0.0061 16.6 2.3 1.5 1 0 0 1 1 1 1 Lipoprotein DUF948 PF06103.11 EWC45191.1 - 0.01 16.0 4.2 0.84 9.9 0.8 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) PLC-beta_C PF08703.10 EWC45191.1 - 0.054 13.5 0.0 0.054 13.5 0.0 2.2 2 1 1 3 3 3 0 PLC-beta C terminal JAKMIP_CC3 PF16034.5 EWC45191.1 - 0.11 12.5 3.6 7 6.5 1.3 2.9 2 1 1 3 3 3 0 JAKMIP CC3 domain Cauli_DNA-bind PF03310.13 EWC45191.1 - 0.17 11.9 5.6 0.43 10.6 2.8 2.6 2 1 0 2 2 2 0 Caulimovirus DNA-binding protein Nup88 PF10168.9 EWC45191.1 - 0.18 9.6 3.5 0.31 8.8 3.5 1.4 1 0 0 1 1 1 0 Nuclear pore component LXG PF04740.12 EWC45191.1 - 0.21 11.3 7.9 0.037 13.7 3.7 1.8 2 0 0 2 2 2 0 LXG domain of WXG superfamily Apolipoprotein PF01442.18 EWC45191.1 - 0.3 10.9 8.2 1.3 8.9 8.2 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain HIP1_clath_bdg PF16515.5 EWC45191.1 - 1 10.0 5.0 1.6 9.4 0.7 2.5 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF16 PF01519.16 EWC45191.1 - 1.7 9.1 9.3 0.35 11.4 0.6 2.4 2 1 1 3 3 3 0 Protein of unknown function DUF16 DUF1664 PF07889.12 EWC45191.1 - 3.2 7.8 10.8 1.1 9.3 1.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EWC45191.1 - 3.7 7.7 10.5 8.7 6.5 4.4 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TMF_TATA_bd PF12325.8 EWC45191.1 - 4.5 7.5 11.2 4.1 7.7 4.5 2.7 2 2 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Prominin PF05478.11 EWC45191.1 - 4.6 5.1 5.2 1.5 6.7 1.7 1.7 2 0 0 2 2 2 0 Prominin Fez1 PF06818.15 EWC45191.1 - 7.4 7.0 7.4 12 6.3 7.4 1.3 1 0 0 1 1 1 0 Fez1 14-3-3 PF00244.20 EWC45192.1 - 5.5e-10 39.1 0.2 9.8e-10 38.3 0.2 1.4 1 0 0 1 1 1 1 14-3-3 protein LIM PF00412.22 EWC45194.1 - 1e-28 99.3 36.6 4.8e-10 39.5 11.7 3.5 3 0 0 3 3 3 3 LIM domain DZR PF12773.7 EWC45194.1 - 2.9 8.0 34.4 8.5 6.5 12.5 4.4 2 1 1 3 3 3 0 Double zinc ribbon Asn_synthase PF00733.21 EWC45195.1 - 3.2e-16 59.9 0.0 9.4e-05 22.2 0.1 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 EWC45195.1 - 4.3e-06 26.6 0.0 9.9e-06 25.5 0.0 1.6 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EWC45195.1 - 0.00011 22.4 0.0 0.00021 21.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain ABC_membrane PF00664.23 EWC45196.1 - 2.4e-36 125.8 8.7 2.4e-36 125.8 8.7 1.7 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 EWC45196.1 - 9.7e-33 113.6 0.0 2.1e-32 112.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EWC45196.1 - 1.3e-07 31.3 0.0 6.3e-07 29.1 0.0 1.8 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EWC45196.1 - 0.0061 16.3 0.0 0.0097 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EWC45196.1 - 0.01 16.3 0.2 0.07 13.6 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 EWC45196.1 - 0.015 15.5 0.3 0.54 10.5 0.2 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 EWC45196.1 - 0.034 14.5 0.2 0.12 12.8 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EWC45196.1 - 0.064 13.5 0.2 0.3 11.4 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EWC45196.1 - 0.093 13.2 0.1 0.18 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.16 EWC45197.1 - 2.7e-54 184.4 0.0 5.7e-52 176.8 0.0 2.7 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EWC45197.1 - 1.1e-05 25.8 1.0 0.0008 19.8 0.3 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EWC45197.1 - 0.00021 21.3 0.0 0.00047 20.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EWC45197.1 - 0.00063 20.2 0.0 0.0016 18.8 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EWC45197.1 - 0.0043 16.4 0.0 0.014 14.8 0.0 1.8 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EWC45197.1 - 0.0081 16.4 0.1 0.15 12.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EWC45197.1 - 0.05 12.9 0.0 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.6 EWC45197.1 - 0.061 13.1 0.0 0.2 11.4 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain SOG2 PF10428.9 EWC45198.1 - 0.17 11.0 33.2 0.079 12.2 0.6 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein PARP PF00644.20 EWC45200.1 - 0.0016 18.1 0.2 0.022 14.3 0.0 2.8 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Glyco_hydro_76 PF03663.14 EWC45201.1 - 5e-151 503.4 14.7 5.8e-151 503.2 14.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EWC45201.1 - 0.056 12.5 13.5 0.096 11.7 0.3 3.1 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Spore_GerQ PF09671.10 EWC45201.1 - 0.078 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Spore coat protein (Spore_GerQ) Lipase_GDSL_2 PF13472.6 EWC45202.1 - 2.6e-08 34.5 0.0 3.1e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Phage_GPA PF05840.13 EWC45203.1 - 0.0019 17.3 0.0 0.0032 16.6 0.0 1.2 1 0 0 1 1 1 1 Bacteriophage replication gene A protein (GPA) eIF3_p135 PF12807.7 EWC45203.1 - 0.13 12.3 0.1 0.22 11.5 0.1 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 MFS_1 PF07690.16 EWC45204.1 - 2.3e-28 99.2 37.9 2.3e-28 99.2 37.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4231 PF14015.6 EWC45204.1 - 6.2 7.3 6.5 1.5 9.3 0.4 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Mannosyl_trans2 PF04188.13 EWC45205.1 - 2.1e-50 172.4 6.6 4.3e-50 171.3 6.6 1.5 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) Kelch_5 PF13854.6 EWC45206.1 - 2e-16 59.5 8.5 1.1e-09 38.1 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EWC45206.1 - 2.2e-13 50.0 15.8 0.0082 16.1 0.1 6.6 6 2 1 7 7 7 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EWC45206.1 - 8e-13 48.3 13.1 0.12 12.7 0.0 6.8 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EWC45206.1 - 7.2e-10 38.3 10.8 0.0012 18.3 0.2 6.2 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 EWC45206.1 - 6.9e-08 32.5 15.8 0.49 10.8 0.1 6.6 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EWC45206.1 - 3.7e-06 26.7 7.5 0.0058 16.6 0.0 5.8 6 0 0 6 6 6 1 Kelch motif LapA_dom PF06305.11 EWC45206.1 - 0.032 14.0 0.5 0.063 13.1 0.5 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Ten1 PF12658.7 EWC45207.1 - 0.00025 21.0 0.0 0.00035 20.5 0.0 1.2 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Rep_fac-A_3 PF08661.11 EWC45207.1 - 0.066 13.6 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Replication factor A protein 3 Forkhead PF00250.18 EWC45208.1 - 4.7e-20 71.6 0.0 1.1e-19 70.4 0.0 1.7 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EWC45208.1 - 0.00023 21.4 0.0 0.00083 19.7 0.0 2.0 2 0 0 2 2 2 1 FHA domain DUF2239 PF09998.9 EWC45208.1 - 0.0055 16.5 0.4 0.88 9.3 0.0 2.7 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2239) AT_hook PF02178.19 EWC45208.1 - 0.87 9.7 7.3 3.6 7.8 7.3 2.1 1 0 0 1 1 1 0 AT hook motif AMPK1_CBM PF16561.5 EWC45209.1 - 5.4e-18 65.0 0.2 1e-17 64.1 0.2 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 EWC45209.1 - 0.0033 17.7 0.1 0.0066 16.8 0.1 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Trehalase PF01204.18 EWC45210.1 - 7.9e-188 625.4 0.0 9.3e-188 625.2 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EWC45210.1 - 4.7e-16 58.2 0.9 8e-16 57.5 0.9 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain cNMP_binding PF00027.29 EWC45211.1 - 3.5e-40 136.0 0.0 2.4e-21 75.6 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 EWC45211.1 - 1.8e-11 43.5 0.7 4.1e-11 42.3 0.7 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit BCAS2 PF05700.11 EWC45212.1 - 1.9e-56 191.0 0.5 2.1e-56 190.9 0.5 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Rox3 PF08633.10 EWC45213.1 - 6.9e-45 153.8 0.1 6.9e-45 153.8 0.1 2.0 2 0 0 2 2 2 1 Rox3 mediator complex subunit Ribosomal_L35Ae PF01247.18 EWC45215.1 - 1e-42 144.2 0.4 1.4e-42 143.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EWC45215.1 - 0.0024 18.0 0.1 1 9.6 0.0 2.3 2 0 0 2 2 2 2 RimM N-terminal domain HA2 PF04408.23 EWC45216.1 - 5.4e-21 74.9 2.1 1.9e-20 73.2 0.0 3.0 4 0 0 4 4 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EWC45216.1 - 3.1e-16 59.5 0.0 9e-16 58.0 0.0 1.8 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EWC45216.1 - 1.3e-13 51.2 0.0 2.8e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EWC45216.1 - 8e-07 29.0 0.1 1.7e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EWC45216.1 - 1.7e-05 25.1 0.0 7.3e-05 23.1 0.1 2.0 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EWC45216.1 - 0.00057 19.2 0.0 0.00099 18.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EWC45216.1 - 0.0029 16.7 0.0 0.0081 15.2 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 EWC45216.1 - 0.003 17.9 0.1 0.0066 16.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EWC45216.1 - 0.0056 16.7 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain SRP54 PF00448.22 EWC45216.1 - 0.0093 15.6 0.3 0.023 14.3 0.3 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ATPase PF06745.13 EWC45216.1 - 0.011 15.1 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_30 PF13604.6 EWC45216.1 - 0.012 15.3 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EWC45216.1 - 0.03 14.3 0.2 0.17 11.9 0.2 2.2 2 1 0 2 2 2 0 AAA domain Microtub_bd PF16796.5 EWC45216.1 - 0.048 13.6 0.0 1.7 8.6 0.0 2.4 2 0 0 2 2 2 0 Microtubule binding AAA_33 PF13671.6 EWC45216.1 - 0.056 13.6 0.3 0.27 11.4 0.0 2.4 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 EWC45216.1 - 0.13 12.7 0.3 0.81 10.2 0.2 2.3 1 1 0 1 1 1 0 ABC transporter Nop14 PF04147.12 EWC45217.1 - 1.3e-278 926.9 8.7 1.6e-278 926.7 8.7 1.1 1 0 0 1 1 1 1 Nop14-like family RNase_P_p30 PF01876.16 EWC45218.1 - 9.3e-66 221.4 0.0 1.3e-65 220.8 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 SRF-TF PF00319.18 EWC45219.1 - 4.9e-23 80.4 0.4 7.9e-23 79.7 0.4 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) TFIIA PF03153.13 EWC45219.1 - 6.5e-07 29.7 38.3 9.5e-07 29.2 38.3 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Tim54 PF11711.8 EWC45219.1 - 0.4 9.4 13.7 0.74 8.5 13.7 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4770 PF15994.5 EWC45219.1 - 0.46 10.7 11.8 1 9.5 11.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) SRP-alpha_N PF04086.13 EWC45219.1 - 0.54 10.1 13.4 1.2 9.0 13.4 1.6 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Gti1_Pac2 PF09729.9 EWC45219.1 - 1.3 9.1 5.8 3.1 7.9 5.8 1.8 1 0 0 1 1 1 0 Gti1/Pac2 family SKA1 PF07160.12 EWC45219.1 - 1.4 8.7 14.4 2.8 7.7 14.4 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 PAT1 PF09770.9 EWC45219.1 - 2 6.6 32.3 0.4 8.9 29.2 1.5 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Hydin_ADK PF17213.3 EWC45219.1 - 4.1 7.6 10.3 10 6.3 10.3 1.7 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF4834 PF16118.5 EWC45219.1 - 5.3 8.1 14.8 4.7 8.2 11.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) eIF-3_zeta PF05091.12 EWC45219.1 - 5.6 5.8 15.6 8 5.3 15.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Plasmodium_Vir PF05795.11 EWC45219.1 - 5.8 6.2 5.7 12 5.2 5.7 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4050 PF13259.6 EWC45219.1 - 6.1 7.1 16.3 3.1 8.1 13.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Rxt3 PF08642.10 EWC45219.1 - 7.1 7.4 6.7 23 5.8 6.7 1.9 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 LIM_bind PF01803.16 EWC45219.1 - 7.9 5.9 15.9 9.3 5.7 14.7 1.6 2 0 0 2 2 2 0 LIM-domain binding protein GREB1 PF15782.5 EWC45219.1 - 9 3.3 12.9 12 2.8 12.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RRF PF01765.19 EWC45220.1 - 3.6e-32 111.5 1.6 5.6e-32 110.9 1.6 1.3 1 0 0 1 1 1 1 Ribosome recycling factor MFS_1 PF07690.16 EWC45221.1 - 4.1e-48 164.1 49.5 4.1e-48 164.1 49.5 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EWC45221.1 - 5e-26 91.3 29.4 1.8e-25 89.4 29.4 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EWC45221.1 - 2.8e-12 46.3 9.6 2.8e-12 46.3 9.6 2.8 2 1 0 2 2 2 2 Sugar (and other) transporter DUF1459 PF07312.11 EWC45221.1 - 0.044 14.0 0.2 0.044 14.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1459) RRN3 PF05327.11 EWC45222.1 - 2.9e-177 590.6 0.0 4e-177 590.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Peptidase_M48_N PF16491.5 EWC45222.1 - 0.0038 17.1 0.1 0.0085 16.0 0.1 1.6 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices UPF0560 PF10577.9 EWC45222.1 - 0.058 11.9 0.0 0.058 11.9 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0560 KIND PF16474.5 EWC45222.1 - 1.5 8.7 5.7 3.2 7.6 4.7 2.0 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain Pkinase PF00069.25 EWC45223.1 - 3.2e-63 213.6 0.0 4.3e-63 213.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45223.1 - 1.3e-47 162.3 0.0 2e-47 161.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC45223.1 - 3.7e-06 26.0 0.0 5.8e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EWC45223.1 - 0.00013 21.4 0.1 0.00055 19.3 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EWC45223.1 - 0.002 17.1 0.3 0.11 11.4 0.1 2.9 3 0 0 3 3 3 1 Haspin like kinase domain RIO1 PF01163.22 EWC45223.1 - 0.0021 17.7 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EWC45223.1 - 0.0091 15.9 0.0 1.7 8.5 0.0 2.4 1 1 0 2 2 2 2 Phosphotransferase enzyme family Telomere_reg-2 PF10193.9 EWC45224.1 - 2.7e-32 111.5 0.5 1.1e-31 109.5 0.0 2.2 2 0 0 2 2 2 1 Telomere length regulation protein DUF2406 PF10295.9 EWC45225.1 - 1e-19 71.0 0.4 1e-19 71.0 0.4 3.2 3 1 0 3 3 3 1 Uncharacterised protein (DUF2406) APG6 PF04111.12 EWC45226.1 - 9.8e-75 250.4 0.0 1.5e-74 249.8 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EWC45226.1 - 3.6e-36 124.6 22.7 3.6e-36 124.6 22.7 1.8 2 0 0 2 2 2 1 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 EWC45226.1 - 0.017 15.3 18.6 0.017 15.3 18.6 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FapA PF03961.13 EWC45226.1 - 0.022 13.4 6.1 0.034 12.8 6.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 EWC45226.1 - 0.049 11.6 7.0 0.073 11.0 7.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 EWC45226.1 - 0.41 9.5 16.6 0.71 8.7 16.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF572 PF04502.13 EWC45226.1 - 0.56 9.8 11.9 0.29 10.7 6.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) YabA PF06156.13 EWC45226.1 - 0.98 10.1 9.2 0.11 13.2 4.0 2.1 2 0 0 2 2 2 0 Initiation control protein YabA Tho2 PF11262.8 EWC45226.1 - 8.7 5.5 8.6 15 4.7 8.6 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Atg14 PF10186.9 EWC45227.1 - 1.8e-48 165.3 2.2 2.6e-48 164.7 2.2 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 tRNA-synt_His PF13393.6 EWC45227.1 - 9.9e-38 130.1 0.5 1.2e-31 110.1 0.0 2.8 3 0 0 3 3 3 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EWC45227.1 - 2.3e-09 37.3 0.0 4.7e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Spectrin PF00435.21 EWC45227.1 - 0.0046 17.4 2.2 0.024 15.1 1.0 2.3 2 0 0 2 2 2 1 Spectrin repeat Rubis-subs-bind PF09273.11 EWC45227.1 - 0.1 13.3 0.8 0.26 12.0 0.8 1.6 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding HEPN_MAE_28990 PF18737.1 EWC45227.1 - 0.14 12.1 0.2 0.3 11.0 0.2 1.5 1 0 0 1 1 1 0 MAE_28990/MAE_18760-like HEPN Streptin-Immun PF11083.8 EWC45227.1 - 0.18 12.2 0.7 0.42 11.1 0.7 1.6 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein TPR_MLP1_2 PF07926.12 EWC45227.1 - 0.21 11.7 2.8 0.5 10.4 2.8 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF2968 PF11180.8 EWC45227.1 - 0.23 11.1 2.0 0.44 10.2 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) GAS PF13851.6 EWC45227.1 - 0.24 10.7 2.8 0.44 9.9 2.8 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med9 PF07544.13 EWC45227.1 - 0.26 11.4 1.4 2.4 8.3 1.4 2.6 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Laminin_II PF06009.12 EWC45227.1 - 3.2 7.8 5.8 2.5 8.1 3.8 1.8 2 0 0 2 2 2 0 Laminin Domain II Chal_sti_synt_C PF02797.15 EWC45228.1 - 4.3 7.3 5.7 2 8.4 0.2 2.8 2 1 2 4 4 4 0 Chalcone and stilbene synthases, C-terminal domain DUF3819 PF12842.7 EWC45228.1 - 9.5 6.2 15.9 1.2 9.0 8.4 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF3819) APH PF01636.23 EWC45229.1 - 1.3e-11 44.9 0.9 1.8e-11 44.4 0.9 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family THUMP PF02926.17 EWC45230.1 - 1.1e-19 70.9 1.4 1.7e-19 70.3 1.4 1.3 1 0 0 1 1 1 1 THUMP domain RINT1_TIP1 PF04437.13 EWC45231.1 - 2.5e-157 524.8 6.1 5.6e-157 523.6 0.0 2.0 2 0 0 2 2 2 1 RINT-1 / TIP-1 family ATP-synt_ab PF00006.25 EWC45231.1 - 0.017 14.8 0.2 0.031 14.0 0.2 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF3572 PF12096.8 EWC45231.1 - 0.11 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) CRISPR_Cse2 PF09485.10 EWC45231.1 - 0.23 12.0 3.4 0.78 10.3 2.6 2.3 1 1 1 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) UPF0240 PF06784.11 EWC45231.1 - 0.23 11.5 2.7 0.46 10.5 2.7 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) MHB PF16525.5 EWC45231.1 - 0.39 11.0 1.7 18 5.7 0.1 3.0 2 0 0 2 2 2 0 Haemophore, haem-binding Snapin_Pallidin PF14712.6 EWC45231.1 - 0.45 11.0 10.4 0.19 12.1 5.1 2.8 2 0 0 2 2 2 0 Snapin/Pallidin Fib_alpha PF08702.10 EWC45231.1 - 3.2 7.9 15.9 0.13 12.5 6.2 3.4 5 0 0 5 5 5 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 EWC45231.1 - 3.3 8.2 7.4 1.6 9.3 3.0 2.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 PDE4_UCR PF18100.1 EWC45231.1 - 3.9 8.1 6.0 1.3 9.7 2.4 2.1 2 0 0 2 2 1 0 Phosphodiesterase 4 upstream conserved regions (UCR) Prominin PF05478.11 EWC45231.1 - 5.4 4.8 8.3 4.9 5.0 6.4 1.7 1 1 1 2 2 2 0 Prominin Allexi_40kDa PF05549.11 EWC45231.1 - 6.2 6.2 7.0 1.9 7.9 2.1 2.4 3 0 0 3 3 3 0 Allexivirus 40kDa protein ABC_tran PF00005.27 EWC45232.1 - 8.8e-30 104.0 0.1 1.5e-29 103.2 0.1 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EWC45232.1 - 2.7e-27 95.6 30.7 3.9e-27 95.1 30.7 1.2 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.6 EWC45232.1 - 5.8e-07 29.6 0.6 0.024 14.5 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EWC45232.1 - 3.3e-06 27.6 0.1 5.9e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EWC45232.1 - 4.2e-05 23.5 0.1 0.00031 20.7 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 EWC45232.1 - 6.7e-05 22.3 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 EWC45232.1 - 0.00033 20.3 0.0 0.00059 19.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EWC45232.1 - 0.00047 20.7 0.0 0.00086 19.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EWC45232.1 - 0.00075 19.7 0.0 0.0013 19.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EWC45232.1 - 0.0016 18.7 0.0 0.0039 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_13 PF13166.6 EWC45232.1 - 0.0019 16.9 0.3 0.083 11.5 0.1 2.2 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EWC45232.1 - 0.0069 15.5 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 EWC45232.1 - 0.0075 16.0 0.1 0.017 14.9 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EWC45232.1 - 0.0079 16.4 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EWC45232.1 - 0.011 16.1 0.0 0.05 14.0 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 EWC45232.1 - 0.012 15.0 0.0 0.15 11.5 0.0 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 EWC45232.1 - 0.018 15.0 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EWC45232.1 - 0.018 14.5 0.3 0.043 13.3 0.0 1.7 2 0 0 2 2 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EWC45232.1 - 0.024 14.7 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EWC45232.1 - 0.031 14.6 0.4 0.094 13.1 0.0 2.0 3 0 0 3 3 1 0 RNA helicase TsaE PF02367.17 EWC45232.1 - 0.032 14.2 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EWC45232.1 - 0.033 14.1 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain KAP_NTPase PF07693.14 EWC45232.1 - 0.044 13.0 0.0 0.072 12.3 0.0 1.4 2 0 0 2 2 2 0 KAP family P-loop domain AAA_30 PF13604.6 EWC45232.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EWC45232.1 - 0.083 13.0 0.4 0.16 12.0 0.4 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.19 EWC45232.1 - 0.11 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EWC45232.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EWC45232.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase SRP54 PF00448.22 EWC45232.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 2 0 0 2 2 1 0 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 EWC45232.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 EWC45232.1 - 0.16 12.5 0.0 0.32 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EWC45232.1 - 0.21 11.5 0.0 0.47 10.3 0.0 1.6 1 0 0 1 1 1 0 NTPase DUF423 PF04241.15 EWC45232.1 - 0.79 10.0 3.9 1.4 9.1 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF423) DNA_ligase_A_M PF01068.21 EWC45233.1 - 3.7e-47 160.6 1.2 2.2e-44 151.6 0.0 2.9 3 0 0 3 3 3 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EWC45233.1 - 6.4e-38 130.8 0.0 1.4e-37 129.7 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EWC45233.1 - 5.1e-22 78.3 0.0 3.7e-21 75.6 0.0 2.5 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EWC45233.1 - 0.00013 22.3 0.0 0.00025 21.4 0.0 1.4 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 EWC45233.1 - 0.036 13.9 0.0 1.4 8.8 0.0 2.6 3 0 0 3 3 3 0 mRNA capping enzyme, catalytic domain DAD PF02109.16 EWC45234.1 - 1.9e-51 172.9 2.9 2.2e-51 172.7 2.9 1.0 1 0 0 1 1 1 1 DAD family DUF1180 PF06679.12 EWC45234.1 - 0.42 11.0 2.9 0.62 10.5 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3844 PF12955.7 EWC45236.1 - 2.1e-29 101.7 5.5 3.3e-29 101.1 5.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) Pro_isomerase PF00160.21 EWC45237.1 - 1.6e-48 164.9 0.6 1.9e-48 164.7 0.6 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-RING_2 PF13639.6 EWC45238.1 - 1.5e-11 44.4 7.0 2.4e-11 43.8 7.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EWC45238.1 - 7.2e-09 35.2 1.3 1.2e-08 34.6 1.3 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EWC45238.1 - 2.1e-08 33.8 6.5 3.4e-08 33.2 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EWC45238.1 - 3.5e-08 33.6 6.5 8.8e-08 32.3 6.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EWC45238.1 - 8.4e-08 32.0 4.8 1.4e-07 31.3 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC45238.1 - 3.4e-06 26.9 4.4 5.3e-06 26.3 4.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EWC45238.1 - 0.00036 20.5 1.1 0.00036 20.5 1.1 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EWC45238.1 - 0.0012 18.8 3.6 0.0025 17.8 3.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EWC45238.1 - 0.003 17.4 3.3 0.0051 16.6 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EWC45238.1 - 0.09 13.0 3.2 0.19 11.9 3.0 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EWC45238.1 - 0.19 11.5 6.8 0.31 10.8 6.8 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EWC45238.1 - 0.22 11.4 5.8 0.4 10.6 5.8 1.4 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EWC45238.1 - 0.29 11.0 4.2 0.53 10.2 3.9 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 OAD_gamma PF04277.13 EWC45238.1 - 0.8 10.3 0.0 0.8 10.3 0.0 3.1 3 1 0 3 3 1 0 Oxaloacetate decarboxylase, gamma chain Zn_ribbon_17 PF17120.5 EWC45238.1 - 1.8 8.3 7.5 4.2 7.1 7.5 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type SOG2 PF10428.9 EWC45238.1 - 2.8 7.0 19.4 2.2 7.4 5.7 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein FANCL_C PF11793.8 EWC45238.1 - 7.8 6.8 7.3 3 8.1 4.0 2.1 2 1 0 2 2 1 0 FANCL C-terminal domain Whi5 PF08528.11 EWC45239.1 - 1.1e-09 37.7 0.3 2e-09 36.9 0.3 1.4 1 0 0 1 1 1 1 Whi5 like tRNA-synt_2c PF01411.19 EWC45240.1 - 1.5e-209 697.1 0.0 2.2e-209 696.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EWC45240.1 - 3.7e-15 55.8 1.0 8.9e-15 54.5 1.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EWC45240.1 - 1.1e-06 29.1 1.2 3.9e-06 27.3 1.2 2.0 1 0 0 1 1 1 1 DHHA1 domain DUF2935 PF11155.8 EWC45240.1 - 0.2 12.0 0.2 1.7 9.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) 4HB_MCP_1 PF12729.7 EWC45240.1 - 0.83 9.2 6.7 4 6.9 0.1 2.6 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Aldedh PF00171.22 EWC45241.1 - 3.9e-142 474.0 0.1 4.5e-142 473.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EWC45241.1 - 6.8e-07 28.7 0.0 9.6e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) cIII PF08134.11 EWC45242.1 - 0.31 10.8 2.9 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 cIII protein family CCDC117 PF15810.5 EWC45242.1 - 0.33 11.3 1.6 9.3 6.6 0.0 2.7 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 117 RCR PF12273.8 EWC45243.1 - 6.3e-09 36.5 10.4 2.2e-08 34.8 10.4 1.8 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF3752 PF12572.8 EWC45244.1 - 4.9e-46 157.0 11.3 4.9e-46 157.0 11.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Pkinase PF00069.25 EWC45245.1 - 9.2e-68 228.5 0.0 1.2e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45245.1 - 5.9e-36 124.1 0.0 9.2e-36 123.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC45245.1 - 2.6e-05 23.7 0.0 3.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EWC45245.1 - 0.00019 20.3 0.1 0.0015 17.4 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EWC45245.1 - 0.013 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SbcD_C PF12320.8 EWC45245.1 - 0.053 13.8 1.3 0.22 11.8 0.0 2.2 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain UQ_con PF00179.26 EWC45246.1 - 4e-24 84.8 0.7 5.3e-24 84.5 0.7 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EWC45246.1 - 1.1e-05 25.1 0.0 2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EWC45246.1 - 0.00041 20.2 0.1 0.00056 19.8 0.1 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 EWC45246.1 - 0.0082 16.4 0.0 0.013 15.7 0.0 1.3 1 1 0 1 1 1 1 RWD domain UFC1 PF08694.11 EWC45246.1 - 0.076 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RNA_pol_A_bac PF01000.26 EWC45247.1 - 1.1e-25 90.1 0.0 2.5e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EWC45247.1 - 1e-21 76.1 0.0 1.9e-21 75.3 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_49kDa PF00346.19 EWC45248.1 - 1.1e-99 332.9 0.0 1.6e-99 332.4 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EWC45248.1 - 0.029 13.3 0.0 0.053 12.4 0.0 1.4 1 1 0 1 1 1 0 Nickel-dependent hydrogenase Peptidase_M1 PF01433.20 EWC45249.1 - 6.1e-07 29.2 0.0 4.2e-06 26.5 0.0 2.4 2 1 0 2 2 2 1 Peptidase family M1 domain HEAT PF02985.22 EWC45249.1 - 0.021 15.0 0.8 0.36 11.2 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat Not3 PF04065.15 EWC45249.1 - 0.066 12.6 0.1 0.2 11.0 0.1 1.7 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF3385 PF11865.8 EWC45249.1 - 0.16 11.9 0.0 0.44 10.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) ThiF PF00899.21 EWC45250.1 - 2.7e-65 220.2 0.0 4.8e-65 219.3 0.0 1.3 1 1 0 1 1 1 1 ThiF family E2_bind PF08825.10 EWC45250.1 - 5.3e-30 103.4 1.3 8.8e-30 102.7 1.3 1.4 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 EWC45250.1 - 0.00054 20.0 0.4 0.0015 18.6 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 EWC45250.1 - 0.064 12.8 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 EWC45250.1 - 0.089 13.4 0.2 0.2 12.2 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EWC45250.1 - 0.093 13.2 0.1 0.25 11.8 0.1 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding PglD_N PF17836.1 EWC45250.1 - 0.098 13.3 0.2 0.22 12.2 0.2 1.6 1 0 0 1 1 1 0 PglD N-terminal domain Ecm33 PF12454.8 EWC45250.1 - 0.12 12.5 2.6 0.24 11.6 2.6 1.4 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein E1_UFD PF09358.10 EWC45250.1 - 0.14 12.9 0.0 0.33 11.7 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin fold domain Sacchrp_dh_NADP PF03435.18 EWC45250.1 - 0.17 12.1 0.2 0.51 10.6 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Sec1 PF00995.23 EWC45251.1 - 2.7e-110 370.3 0.0 3.1e-110 370.1 0.0 1.0 1 0 0 1 1 1 1 Sec1 family FAD_binding_3 PF01494.19 EWC45252.1 - 3.3e-29 102.3 0.0 4e-28 98.7 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EWC45252.1 - 1.9e-05 23.9 0.2 0.00021 20.5 0.1 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.24 EWC45252.1 - 0.00058 19.5 0.0 0.0032 17.1 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EWC45252.1 - 0.002 17.4 0.0 0.0036 16.6 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EWC45252.1 - 0.0027 17.0 0.0 0.0043 16.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 EWC45252.1 - 0.0031 16.4 0.3 0.054 12.3 0.2 2.4 3 0 0 3 3 3 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EWC45252.1 - 0.0062 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding SE PF08491.10 EWC45252.1 - 0.036 13.1 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase Pyr_redox PF00070.27 EWC45252.1 - 0.075 13.6 0.2 0.21 12.2 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EWC45252.1 - 0.11 11.2 0.4 0.24 10.1 0.2 1.6 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.6 EWC45252.1 - 0.21 11.8 0.5 0.52 10.6 0.5 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Fungal_trans PF04082.18 EWC45253.1 - 2.7e-22 79.1 0.0 4.4e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC45253.1 - 2.9e-05 24.1 9.8 5.3e-05 23.3 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Homoserine_dh PF00742.19 EWC45255.1 - 7.2e-52 175.8 0.0 1e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EWC45255.1 - 3.7e-16 59.8 0.0 6.4e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Amidase PF01425.21 EWC45256.1 - 1.3e-71 241.9 0.0 1.7e-71 241.5 0.0 1.2 1 0 0 1 1 1 1 Amidase Isochorismatase PF00857.20 EWC45256.1 - 5.5e-38 130.9 0.0 1.1e-37 129.9 0.0 1.5 1 0 0 1 1 1 1 Isochorismatase family Transp_cyt_pur PF02133.15 EWC45257.1 - 1.2e-76 258.3 34.0 1.4e-76 258.1 34.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SAS4 PF15460.6 EWC45258.1 - 8.7e-11 41.8 0.4 8.7e-11 41.8 0.4 2.8 3 0 0 3 3 3 1 Something about silencing, SAS, complex subunit 4 DHHC PF01529.20 EWC45260.1 - 1.7e-27 96.1 11.3 1.7e-27 96.1 11.3 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Chitin_synth_2 PF03142.15 EWC45261.1 - 2.7e-286 950.3 1.7 2.2e-285 947.3 0.3 2.0 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EWC45261.1 - 2.7e-12 47.0 2.9 2.7e-12 47.0 2.9 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EWC45261.1 - 1.1e-11 45.0 0.1 5.5e-10 39.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EWC45261.1 - 3.3e-05 23.4 0.1 0.0009 18.8 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EWC45261.1 - 0.0068 16.2 0.0 0.028 14.2 0.0 2.0 3 0 0 3 3 3 1 Glycosyl transferase family 2 Gram_pos_anchor PF00746.21 EWC45262.1 - 0.16 11.9 0.4 0.33 10.9 0.4 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Sel1 PF08238.12 EWC45263.1 - 3.9e-28 97.2 30.8 8.3e-05 23.1 1.0 7.6 7 0 0 7 7 7 7 Sel1 repeat Cation_efflux PF01545.21 EWC45264.1 - 5.4e-50 169.9 15.7 1.9e-49 168.1 15.7 1.8 1 1 0 1 1 1 1 Cation efflux family Pkinase PF00069.25 EWC45265.1 - 3.1e-74 249.7 0.0 4.3e-74 249.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45265.1 - 2.6e-38 131.8 0.0 4.3e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EWC45265.1 - 1.6e-15 57.0 0.3 1.7e-07 31.3 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EWC45265.1 - 3.4e-08 33.2 0.0 1.4e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EWC45265.1 - 0.0056 15.5 0.0 0.011 14.5 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EWC45265.1 - 0.0079 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EWC45265.1 - 0.024 13.6 0.0 0.038 12.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain OPA3 PF07047.12 EWC45266.1 - 1.2e-50 170.5 0.2 1.6e-50 170.1 0.2 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) DHDPS PF00701.22 EWC45267.1 - 3e-35 121.4 0.0 3.6e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Myosin_head PF00063.21 EWC45268.1 - 1.5e-239 796.8 5.4 1.8e-239 796.5 5.4 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EWC45268.1 - 7.8e-50 169.2 0.0 1.3e-49 168.4 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EWC45268.1 - 1.4e-13 50.2 0.2 2.7e-13 49.3 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC45268.1 - 8.8e-10 38.3 0.0 2.4e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EWC45268.1 - 2.9e-08 33.3 0.2 1e-07 31.5 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain AAA_22 PF13401.6 EWC45268.1 - 0.017 15.4 0.0 0.058 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EWC45268.1 - 0.1 13.0 0.0 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 EWC45268.1 - 0.12 12.3 0.1 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Hpr_kinase_C PF07475.12 EWC45268.1 - 0.41 10.2 1.7 13 5.3 0.0 2.7 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain DnaGprimase_HBD PF16730.5 EWC45268.1 - 0.91 9.6 3.5 1.8 8.7 0.5 2.4 2 0 0 2 2 2 0 DnaG-primase C-terminal, helicase-binding domain IQ PF00612.27 EWC45268.1 - 4.2 7.4 17.3 0.53 10.2 0.4 3.0 3 0 0 3 3 2 0 IQ calmodulin-binding motif Asp PF00026.23 EWC45269.1 - 0.00058 19.4 0.0 0.019 14.4 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease ATP-synt PF00231.19 EWC45270.1 - 1.1e-74 251.6 2.8 1.4e-74 251.3 2.8 1.0 1 0 0 1 1 1 1 ATP synthase Topoisom_I PF01028.20 EWC45271.1 - 5.4e-94 313.8 10.5 5.4e-94 313.8 10.5 2.3 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EWC45271.1 - 1.2e-92 309.2 4.9 1.2e-92 309.2 4.9 4.0 4 1 2 6 6 6 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EWC45271.1 - 4.3e-30 103.5 0.4 2e-29 101.3 0.4 2.3 1 0 0 1 1 1 1 C-terminal topoisomerase domain DNA_mis_repair PF01119.19 EWC45272.1 - 2.5e-09 36.8 0.0 4.4e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EWC45272.1 - 5.1e-07 29.6 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EWC45272.1 - 0.0004 20.9 0.0 0.00093 19.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DP-EP PF08985.11 EWC45272.1 - 0.016 15.4 0.3 0.08 13.1 0.1 2.0 2 0 0 2 2 2 0 DP-EP family Y_phosphatase2 PF03162.13 EWC45273.1 - 4.3e-44 150.0 0.0 3.7e-43 147.0 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EWC45273.1 - 6.8e-08 32.8 0.0 8.6e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family LYRIC PF15686.5 EWC45273.1 - 0.0071 15.9 0.7 0.0086 15.7 0.7 1.1 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family DSPc PF00782.20 EWC45273.1 - 0.061 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EWC45273.1 - 0.072 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF5615 PF18480.1 EWC45273.1 - 0.083 12.7 0.3 0.24 11.2 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5615) Dynamitin PF04912.14 EWC45274.1 - 3.7e-78 263.5 11.8 5.6e-78 263.0 11.8 1.3 1 0 0 1 1 1 1 Dynamitin Laminin_II PF06009.12 EWC45274.1 - 0.011 15.8 1.3 0.011 15.8 1.3 3.9 5 0 0 5 5 5 0 Laminin Domain II DUF812 PF05667.11 EWC45274.1 - 0.014 14.3 13.5 0.035 13.0 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF1664 PF07889.12 EWC45274.1 - 0.15 12.1 11.3 0.096 12.7 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EWC45274.1 - 0.51 10.5 8.3 5 7.3 0.9 3.3 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 EWC45274.1 - 0.74 9.2 20.7 0.41 10.1 1.2 3.1 3 0 0 3 3 3 0 Golgin subfamily A member 5 Rx_N PF18052.1 EWC45274.1 - 1.6 9.1 17.0 0.39 11.0 1.9 3.5 3 0 0 3 3 3 0 Rx N-terminal domain SKA1 PF07160.12 EWC45274.1 - 2.5 7.9 9.8 2.5 7.9 0.4 2.7 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 CorA PF01544.18 EWC45274.1 - 3.9 6.7 10.7 0.65 9.3 4.8 2.4 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein TerB_C PF15615.6 EWC45274.1 - 4.6 7.5 17.2 0.058 13.7 8.4 2.3 3 0 0 3 3 3 0 TerB-C domain Spc7 PF08317.11 EWC45274.1 - 5.7 5.7 18.9 2.8 6.7 0.8 3.8 4 0 0 4 4 4 0 Spc7 kinetochore protein AAA_23 PF13476.6 EWC45274.1 - 8.6 6.8 9.8 1.1 9.7 1.3 2.5 2 1 0 2 2 2 0 AAA domain WD40 PF00400.32 EWC45275.1 - 0.00033 21.4 0.1 0.017 16.0 0.1 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC45275.1 - 0.0015 18.8 0.0 1 9.7 0.0 3.8 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain ENTH PF01417.20 EWC45276.1 - 6.5e-47 158.7 0.0 9.6e-47 158.1 0.0 1.2 1 0 0 1 1 1 1 ENTH domain UIM PF02809.20 EWC45276.1 - 3.1e-05 23.6 1.6 0.0039 17.0 0.5 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif DUF4264 PF14084.6 EWC45276.1 - 0.043 13.4 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) GREB1 PF15782.5 EWC45276.1 - 2.3 5.2 9.0 3.1 4.8 9.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DTHCT PF08070.11 EWC45276.1 - 2.4 8.9 7.3 4.6 8.0 7.3 1.4 1 0 0 1 1 1 0 DTHCT (NUC029) region Suc_Fer-like PF06999.12 EWC45277.1 - 2.5e-63 213.5 0.3 4.1e-63 212.8 0.3 1.3 1 1 0 1 1 1 1 Sucrase/ferredoxin-like AA_permease PF00324.21 EWC45278.1 - 2.2e-101 339.8 35.3 5e-101 338.7 35.3 1.5 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EWC45278.1 - 5.3e-32 111.2 34.1 9.4e-32 110.4 34.2 1.4 1 1 0 1 1 1 1 Amino acid permease DUF1992 PF09350.10 EWC45279.1 - 1.2e-18 67.0 0.4 3.1e-18 65.7 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) Imm32 PF15566.6 EWC45279.1 - 0.11 12.3 0.2 5.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Immunity protein 32 SRP40_C PF05022.12 EWC45280.1 - 1.1e-24 87.0 1.6 3.1e-24 85.6 1.6 1.8 1 0 0 1 1 1 1 SRP40, C-terminal domain LisH PF08513.11 EWC45280.1 - 0.035 14.1 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 LisH Sec3_C PF09763.9 EWC45281.1 - 3.9e-160 534.6 12.7 6.1e-160 533.9 12.7 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EWC45281.1 - 1.8e-27 95.2 0.0 4e-27 94.2 0.0 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 EWC45281.1 - 0.00056 18.8 1.6 0.0013 17.6 1.6 1.5 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C_2 PF15278.6 EWC45281.1 - 0.053 13.9 0.2 0.053 13.9 0.2 2.3 3 0 0 3 3 3 0 Sec3 exocyst complex subunit NTP_transferase PF00483.23 EWC45282.1 - 1.3e-51 175.6 0.0 2e-51 175.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EWC45282.1 - 3.3e-17 61.5 17.9 1.2e-10 40.6 4.9 3.6 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EWC45282.1 - 3.2e-10 40.6 0.0 4.8e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EWC45282.1 - 1.6e-05 24.6 1.9 1.6e-05 24.6 1.9 2.7 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EWC45282.1 - 0.00011 20.6 0.3 0.00026 19.3 0.1 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4954) Ribosomal_L7Ae PF01248.26 EWC45282.1 - 0.092 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family IspD PF01128.19 EWC45282.1 - 0.096 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase LRR_4 PF12799.7 EWC45283.1 - 8.6e-05 22.8 10.1 0.021 15.2 0.2 4.8 3 1 3 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EWC45283.1 - 0.0041 17.1 10.3 0.22 11.7 0.0 5.6 6 0 0 6 6 6 2 Leucine Rich repeat LRR_8 PF13855.6 EWC45283.1 - 0.025 14.3 8.7 0.11 12.2 0.3 4.2 4 1 0 4 4 4 0 Leucine rich repeat F-box PF00646.33 EWC45284.1 - 0.0046 16.8 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain V_ATPase_I PF01496.19 EWC45285.1 - 0 1061.9 0.6 0 1061.7 0.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family PI3K_P85_iSH2 PF16454.5 EWC45285.1 - 0.023 14.3 2.3 0.086 12.4 0.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain BLOC1_2 PF10046.9 EWC45285.1 - 0.051 13.9 2.6 0.74 10.1 0.1 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4988 PF16378.5 EWC45285.1 - 0.19 11.4 1.2 0.23 11.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function Snapin_Pallidin PF14712.6 EWC45285.1 - 0.2 12.1 0.8 2.7 8.5 0.0 2.6 2 0 0 2 2 2 0 Snapin/Pallidin YabA PF06156.13 EWC45285.1 - 0.38 11.4 2.0 2.1 9.0 0.1 2.5 2 0 0 2 2 2 0 Initiation control protein YabA EzrA PF06160.12 EWC45285.1 - 0.42 8.7 4.8 3.7 5.6 0.1 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA SOAR PF16533.5 EWC45285.1 - 0.66 10.0 2.1 2.3 8.3 0.3 2.3 2 0 0 2 2 2 0 STIM1 Orai1-activating region DASH_Dam1 PF08653.10 EWC45285.1 - 0.76 9.6 4.5 5 7.0 0.0 4.0 5 0 0 5 5 5 0 DASH complex subunit Dam1 THP2 PF09432.10 EWC45285.1 - 0.9 9.6 3.9 0.61 10.1 1.4 1.9 2 0 0 2 2 2 0 Tho complex subunit THP2 DivIC PF04977.15 EWC45285.1 - 1.3 8.9 4.2 19 5.1 0.1 3.0 3 0 0 3 3 3 0 Septum formation initiator PH_10 PF15411.6 EWC45286.1 - 3.5e-38 130.6 0.1 7.2e-38 129.6 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EWC45286.1 - 1.5e-32 113.3 0.1 4.2e-32 111.8 0.0 1.8 2 0 0 2 2 2 1 RhoGEF domain CDC24 PF06395.11 EWC45286.1 - 6.1e-18 64.9 0.1 1.4e-17 63.7 0.1 1.7 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.24 EWC45286.1 - 2.8e-13 49.6 0.0 7.1e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 PB1 domain HsbA PF12296.8 EWC45286.1 - 0.017 15.6 1.3 0.045 14.2 0.5 2.1 2 0 0 2 2 2 0 Hydrophobic surface binding protein A PH PF00169.29 EWC45286.1 - 0.083 13.4 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 PH domain BRAP2 PF07576.12 EWC45287.1 - 1.5e-30 105.3 0.0 2.6e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EWC45287.1 - 1.7e-20 73.1 6.0 4.1e-20 71.9 6.0 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EWC45287.1 - 6.2e-09 36.0 9.7 6.2e-09 36.0 9.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC45287.1 - 1.5e-06 27.9 10.1 1.5e-06 27.9 10.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EWC45287.1 - 9.3e-06 25.8 7.5 2.3e-05 24.6 7.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EWC45287.1 - 1.5e-05 24.9 8.1 1.5e-05 24.9 8.1 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 EWC45287.1 - 4.6e-05 23.1 4.2 4.6e-05 23.1 4.2 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EWC45287.1 - 6.6e-05 22.8 4.6 6.6e-05 22.8 4.6 2.9 1 1 1 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EWC45287.1 - 0.0001 22.1 8.8 0.0001 22.1 8.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC45287.1 - 0.0003 20.6 5.9 0.0003 20.6 5.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EWC45287.1 - 0.00068 19.6 5.3 0.0015 18.5 5.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EWC45287.1 - 0.15 11.9 7.3 0.36 10.7 7.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4407 PF14362.6 EWC45287.1 - 0.16 11.3 2.6 0.24 10.7 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-RING_6 PF14835.6 EWC45287.1 - 0.32 10.9 5.1 0.36 10.7 3.4 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EWC45287.1 - 0.44 10.5 20.0 0.86 9.5 10.4 3.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EWC45287.1 - 0.93 9.2 15.6 0.058 13.0 6.0 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prenyltrans PF00432.21 EWC45288.1 - 7.5e-33 112.0 28.7 4.9e-07 29.4 0.0 6.6 7 0 0 7 7 7 6 Prenyltransferase and squalene oxidase repeat Hexapep PF00132.24 EWC45290.1 - 7.1e-09 35.1 10.3 3.3e-05 23.4 0.2 4.2 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EWC45290.1 - 7.1e-08 32.1 11.3 8.8e-05 22.2 1.1 3.2 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EWC45290.1 - 0.26 10.2 0.5 15 4.4 0.0 2.1 1 1 1 2 2 2 0 L-fucokinase PhoD PF09423.10 EWC45291.1 - 2.8e-44 151.6 0.1 6.4e-44 150.4 0.1 1.5 1 1 0 1 1 1 1 PhoD-like phosphatase Pur_ac_phosph_N PF16656.5 EWC45291.1 - 0.0038 17.8 0.1 0.0099 16.4 0.1 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 EWC45291.1 - 0.061 13.7 0.6 0.22 11.9 0.6 2.0 1 0 0 1 1 1 0 Fibronectin type III domain Acetyltransf_8 PF13523.6 EWC45292.1 - 1.9e-35 121.7 0.7 9.1e-28 96.8 1.6 2.2 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EWC45292.1 - 0.00036 21.2 0.0 0.004 17.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Thiolase_N PF00108.23 EWC45293.1 - 5.8e-75 252.0 6.8 7.9e-75 251.6 5.6 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EWC45293.1 - 3.1e-45 152.8 0.3 3.1e-45 152.8 0.3 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EWC45293.1 - 0.0022 17.6 3.7 0.024 14.2 1.5 2.6 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 EWC45293.1 - 0.059 13.5 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ubiquitin PF00240.23 EWC45294.1 - 6.4e-204 660.2 32.1 2.5e-33 113.6 0.5 6.0 6 0 0 6 6 6 6 Ubiquitin family Rad60-SLD PF11976.8 EWC45294.1 - 3e-93 305.7 35.0 5.7e-15 54.9 0.6 6.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EWC45294.1 - 3.1e-33 114.1 16.7 0.00084 19.8 0.1 8.1 6 6 0 6 6 6 6 Ubiquitin-like domain TBK1_ULD PF18396.1 EWC45294.1 - 8.8e-23 80.0 8.3 0.06 13.3 0.0 6.2 6 0 0 6 6 6 6 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EWC45294.1 - 1.3e-20 73.5 6.5 0.21 11.7 0.0 7.1 6 5 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EWC45294.1 - 3.4e-20 72.2 15.9 0.08 13.3 0.1 6.1 6 0 0 6 6 6 6 Ubiquitin-like domain DUF2407 PF10302.9 EWC45294.1 - 1.1e-18 67.6 4.0 0.61 10.7 0.0 6.2 1 1 2 6 6 6 6 DUF2407 ubiquitin-like domain Methyltrans_RNA PF04452.14 EWC45294.1 - 4.6e-11 42.5 3.4 1.9 7.8 0.0 5.2 5 0 0 5 5 5 5 RNA methyltransferase DUF2870 PF11069.8 EWC45294.1 - 7.6e-09 35.8 0.0 50 4.4 0.0 6.8 6 0 0 6 6 6 0 Protein of unknown function (DUF2870) Big_7 PF17957.1 EWC45294.1 - 8e-09 36.1 1.2 52 4.7 0.0 6.1 6 0 0 6 6 6 0 Bacterial Ig domain TmoB PF06234.12 EWC45294.1 - 2.5e-08 33.9 0.1 50 4.1 0.0 6.7 6 0 0 6 6 6 0 Toluene-4-monooxygenase system protein B (TmoB) Ubiquitin_4 PF18036.1 EWC45294.1 - 4.8e-08 32.9 40.9 27 4.9 0.2 11.9 12 0 0 12 12 12 0 Ubiquitin-like domain DUF3861 PF12977.7 EWC45294.1 - 9.9e-08 32.1 8.4 23 5.3 0.0 6.2 6 0 0 6 6 6 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 EWC45294.1 - 1.9e-07 30.8 9.3 19 5.2 0.0 6.3 6 0 0 6 6 6 0 ACT domain UDP-g_GGTase PF06427.11 EWC45294.1 - 4e-07 30.1 8.8 12 6.0 0.0 5.8 6 0 0 6 6 6 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EWC45294.1 - 2.1e-06 27.3 0.3 38 3.6 0.0 5.8 6 0 0 6 6 6 0 Protein of unknown function (DUF969) ACT_4 PF13291.6 EWC45294.1 - 1.8e-05 25.3 4.0 1.2e+02 3.4 0.0 6.2 6 0 0 6 6 6 0 ACT domain DUF493 PF04359.14 EWC45294.1 - 5.6e-05 23.6 0.2 2.3e+02 2.4 0.0 5.8 6 0 0 6 6 6 0 Protein of unknown function (DUF493) ORF11CD3 PF10549.9 EWC45294.1 - 8.4e-05 22.6 0.0 1.5e+02 2.6 0.0 6.0 6 0 0 6 6 6 0 ORF11CD3 domain ProRS-C_2 PF09181.10 EWC45294.1 - 0.0074 16.4 11.8 1.1e+02 3.1 0.1 6.0 6 0 0 6 6 6 0 Prolyl-tRNA synthetase, C-terminal FlgD_ig PF13860.6 EWC45294.1 - 0.081 12.8 17.8 72 3.4 0.1 6.3 6 0 0 6 6 6 0 FlgD Ig-like domain Tash_PEST PF07708.11 EWC45294.1 - 0.33 11.2 44.7 9.8 6.5 1.4 6.3 6 0 0 6 6 6 0 Tash protein PEST motif Phage_sheath_1N PF17481.2 EWC45294.1 - 1.1 9.8 16.7 2.4e+02 2.3 0.1 5.8 1 1 1 2 2 1 0 Phage tail sheath protein beta-sandwich domain PI3K_p85B PF02192.16 EWC45294.1 - 9.5 6.0 16.8 1.6e+02 2.2 0.1 6.0 6 0 0 6 6 6 0 PI3-kinase family, p85-binding domain Cnl2_NKP2 PF09447.10 EWC45294.1 - 9.6 6.4 18.9 1.6e+02 2.5 0.1 6.2 6 0 0 6 6 6 0 Cnl2/NKP2 family protein FBPase PF00316.20 EWC45295.1 - 3.8e-68 228.7 0.4 5e-68 228.3 0.4 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EWC45295.1 - 0.031 13.8 0.0 0.08 12.4 0.0 1.6 2 0 0 2 2 2 0 Inositol monophosphatase family Ribosomal_S7e PF01251.18 EWC45298.1 - 9.8e-83 276.4 0.1 1.2e-82 276.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Kri1_C PF12936.7 EWC45300.1 - 3.5e-24 84.8 0.1 3.5e-24 84.8 0.1 4.1 4 0 0 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 EWC45300.1 - 7.4e-22 77.9 18.4 7.4e-22 77.9 18.4 5.8 4 2 3 7 7 7 1 KRI1-like family Yippee-Mis18 PF03226.14 EWC45301.1 - 1.5e-16 60.5 0.2 1.8e-16 60.2 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HNH_5 PF14279.6 EWC45301.1 - 0.027 14.3 0.5 0.67 9.9 0.1 2.2 2 0 0 2 2 2 0 HNH endonuclease Jas PF16135.5 EWC45301.1 - 0.077 13.2 0.8 0.077 13.2 0.8 1.7 1 1 1 2 2 2 0 TPL-binding domain in jasmonate signalling DUF3268 PF11672.8 EWC45301.1 - 0.11 12.8 1.5 0.66 10.3 0.1 2.0 2 0 0 2 2 2 0 zinc-finger-containing domain Endonuclease_7 PF02945.15 EWC45301.1 - 0.2 11.6 3.2 1.2 9.1 3.2 1.9 1 1 0 1 1 1 0 Recombination endonuclease VII Tropomyosin PF00261.20 EWC45302.1 - 0.0065 15.9 4.0 0.0065 15.9 4.0 1.9 3 0 0 3 3 3 1 Tropomyosin SpecificRecomb PF10136.9 EWC45302.1 - 0.29 9.4 1.9 0.32 9.3 1.2 1.4 2 0 0 2 2 2 0 Site-specific recombinase XhlA PF10779.9 EWC45302.1 - 0.31 11.3 4.5 0.12 12.6 1.6 1.8 2 0 0 2 2 2 0 Haemolysin XhlA SIKE PF05769.11 EWC45302.1 - 0.65 9.9 10.9 0.042 13.8 4.1 2.2 1 1 1 2 2 2 0 SIKE family DUF5595 PF18077.1 EWC45302.1 - 0.89 9.7 3.9 2.4 8.3 3.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) HSCB_C PF07743.13 EWC45302.1 - 2.3 8.8 9.5 0.46 11.0 2.2 2.7 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain YabA PF06156.13 EWC45302.1 - 3.2 8.5 9.5 0.084 13.5 1.5 2.3 3 0 0 3 3 3 0 Initiation control protein YabA ATG16 PF08614.11 EWC45302.1 - 4.5 7.4 14.3 9.9 6.3 14.3 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3340 PF11818.8 EWC45302.1 - 8.7 6.5 11.4 0.84 9.8 4.6 2.1 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) CAP_N PF01213.19 EWC45302.1 - 9.3 5.6 11.6 1.5 8.2 5.8 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Sen15 PF09631.10 EWC45303.1 - 4e-23 81.6 0.0 5e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Sen15 protein DUF2985 PF11204.8 EWC45304.1 - 1.2e-39 134.3 1.2 1.2e-39 134.3 1.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) adh_short PF00106.25 EWC45308.1 - 6.7e-21 74.6 0.1 6.4e-18 64.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC45308.1 - 6.9e-12 45.4 0.0 1.6e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC45308.1 - 9.3e-06 25.7 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EWC45308.1 - 5.7e-05 22.5 0.1 0.00011 21.5 0.1 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF4096 PF13340.6 EWC45308.1 - 0.038 14.2 0.0 11 6.3 0.0 3.0 2 0 0 2 2 2 0 Putative transposase of IS4/5 family (DUF4096) Cation_ATPase_C PF00689.21 EWC45309.1 - 1.3e-48 165.2 11.0 3.7e-48 163.6 11.0 1.9 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EWC45309.1 - 8.6e-36 123.2 1.7 8.6e-36 123.2 1.7 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EWC45309.1 - 2.4e-22 78.8 0.0 4.7e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EWC45309.1 - 2.5e-20 73.7 0.0 6.6e-20 72.3 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EWC45309.1 - 3.1e-08 33.2 0.0 4.1e-07 29.6 0.0 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EWC45309.1 - 6.1e-06 26.2 0.2 0.00053 19.8 0.2 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase EamA PF00892.20 EWC45309.1 - 0.99 9.6 11.0 0.046 13.9 1.9 2.9 2 0 0 2 2 2 0 EamA-like transporter family DUF3099 PF11298.8 EWC45309.1 - 3.6 7.8 5.8 1.2 9.4 1.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) zf-CCHC PF00098.23 EWC45310.1 - 0.98 9.6 4.5 2.2 8.5 4.5 1.6 1 0 0 1 1 1 0 Zinc knuckle zf_C2H2_13 PF18508.1 EWC45310.1 - 5.3 6.7 5.7 23 4.7 5.7 2.0 1 1 0 1 1 1 0 Zinc finger domain ZapB PF06005.12 EWC45311.1 - 0.15 12.5 2.2 10 6.6 0.7 2.3 2 0 0 2 2 2 0 Cell division protein ZapB Pox_A_type_inc PF04508.12 EWC45311.1 - 6.3 6.8 5.4 0.7 9.9 0.9 1.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat bZIP_1 PF00170.21 EWC45314.1 - 0.00022 21.3 30.4 0.038 14.1 4.0 5.2 3 1 2 5 5 5 3 bZIP transcription factor YabA PF06156.13 EWC45314.1 - 0.0033 18.0 24.5 0.013 16.2 0.1 4.3 1 1 2 3 3 3 1 Initiation control protein YabA DivIC PF04977.15 EWC45314.1 - 0.0044 16.8 4.5 0.0044 16.8 4.5 5.0 1 1 4 5 5 5 2 Septum formation initiator Macoilin PF09726.9 EWC45314.1 - 0.005 15.5 18.8 0.0061 15.2 18.8 1.3 1 0 0 1 1 1 1 Macoilin family TSC22 PF01166.18 EWC45314.1 - 0.021 15.1 0.1 0.021 15.1 0.1 4.8 4 1 2 6 6 5 0 TSC-22/dip/bun family FlaC_arch PF05377.11 EWC45314.1 - 0.2 12.0 10.7 15 6.0 0.3 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) KASH_CCD PF14662.6 EWC45314.1 - 0.21 11.4 35.5 3.6 7.4 4.8 3.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 EWC45314.1 - 0.65 8.8 34.1 0.39 9.5 6.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Shugoshin_N PF07558.11 EWC45314.1 - 0.93 9.4 11.9 9.3 6.2 0.3 3.9 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region APG6_N PF17675.1 EWC45314.1 - 2.2 8.8 55.6 0.58 10.7 22.3 4.2 2 2 2 4 4 4 0 Apg6 coiled-coil region GAS PF13851.6 EWC45314.1 - 2.9 7.2 37.3 1.2 8.5 23.5 3.7 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding DUF4201 PF13870.6 EWC45314.1 - 2.9 7.6 35.6 0.046 13.5 5.3 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF4201) CENP-F_leu_zip PF10473.9 EWC45314.1 - 4.2 7.4 40.9 5.7 7.0 15.5 3.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-H PF05837.12 EWC45314.1 - 5 7.6 30.4 11 6.5 0.1 4.1 2 1 2 4 4 4 0 Centromere protein H (CENP-H) FapA PF03961.13 EWC45314.1 - 8 4.9 22.4 1.8 7.1 4.0 2.5 1 1 1 2 2 2 0 Flagellar Assembly Protein A HOOK PF05622.12 EWC45314.1 - 8.1 4.4 37.7 2.7 6.0 7.3 3.0 1 1 2 3 3 3 0 HOOK protein Pectate_lyase_3 PF12708.7 EWC45316.1 - 2.3e-88 295.6 4.2 4.6e-75 252.2 0.3 2.4 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EWC45316.1 - 3e-05 23.6 1.4 0.031 14.0 0.2 2.8 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase LCCL PF03815.19 EWC45317.1 - 3.1e-17 62.5 0.0 5e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 LCCL domain Tox-HNH-EHHH PF15657.6 EWC45317.1 - 0.12 12.7 2.7 0.24 11.8 2.7 1.4 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxins Sugar_tr PF00083.24 EWC45318.1 - 1.2e-82 278.2 9.8 1.6e-82 277.8 9.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC45318.1 - 5.8e-24 84.7 28.2 8.6e-24 84.1 28.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Trep_Strep PF09605.10 EWC45318.1 - 0.84 9.6 11.8 0.039 13.9 3.4 2.5 3 0 0 3 3 3 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Glyco_hydro_31 PF01055.26 EWC45319.1 - 1.8e-135 452.6 0.6 2.2e-135 452.3 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EWC45319.1 - 3.7e-20 72.3 0.0 6.6e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EWC45319.1 - 3.8e-07 30.3 0.1 1.1e-06 28.9 0.1 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 EWC45319.1 - 0.023 15.0 0.0 0.073 13.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) Rit1_C PF17184.4 EWC45319.1 - 0.033 13.6 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Rit1 N-terminal domain DUF3510 PF12022.8 EWC45320.1 - 0.025 15.0 0.7 3 8.2 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) PEP-utilisers_N PF05524.13 EWC45320.1 - 0.068 13.3 0.9 2 8.6 0.2 2.4 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Cas_Csx9 PF09658.10 EWC45320.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csx9) SesA PF17107.5 EWC45320.1 - 0.13 12.4 1.5 3.5 7.8 0.0 2.2 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1664 PF07889.12 EWC45320.1 - 0.83 9.7 3.1 0.89 9.6 0.8 2.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) AAA_12 PF13087.6 EWC45321.1 - 4.4e-21 75.4 0.2 8.7e-21 74.5 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EWC45321.1 - 7.6e-19 68.5 0.0 1.8e-18 67.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EWC45321.1 - 4.2e-07 30.4 0.0 1e-05 25.9 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC45321.1 - 0.00034 20.4 0.0 0.1 12.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 EWC45321.1 - 0.063 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein DUF1611 PF07755.11 EWC45321.1 - 0.14 11.5 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain Peptidase_M10 PF00413.24 EWC45323.1 - 1.1e-12 48.1 0.1 1.6e-12 47.5 0.1 1.2 1 0 0 1 1 1 1 Matrixin Metallopep PF12044.8 EWC45323.1 - 1.3e-07 30.7 0.2 1.8e-07 30.2 0.2 1.2 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.6 EWC45323.1 - 9.3e-06 25.9 0.0 1.1e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EWC45323.1 - 2.8e-05 23.9 0.0 3.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EWC45323.1 - 9.9e-05 21.4 0.3 0.00014 21.0 0.3 1.2 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_3 PF13582.6 EWC45323.1 - 0.00011 22.7 0.1 0.00016 22.1 0.1 1.3 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 EWC45323.1 - 0.0042 17.1 0.0 0.0073 16.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M54 Reprolysin_2 PF13574.6 EWC45323.1 - 0.023 14.6 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EWC45323.1 - 0.38 9.9 2.9 0.31 10.2 1.1 1.6 2 0 0 2 2 2 0 Met-zincin Na_H_Exchanger PF00999.21 EWC45325.1 - 1.4e-75 254.4 17.9 1.7e-75 254.2 17.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.10 EWC45325.1 - 2.5e-45 155.6 27.5 1e-38 133.8 19.3 2.8 1 1 1 2 2 2 2 Alkali metal cation/H+ antiporter Nha1 C terminus DUF21 PF01595.20 EWC45325.1 - 0.0085 15.8 1.9 0.022 14.5 1.9 1.7 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain Colicin_E5 PF12106.8 EWC45325.1 - 0.047 14.0 3.4 0.11 12.8 0.2 2.7 3 0 0 3 3 3 0 Colicin E5 ribonuclease domain Nop16 PF09420.10 EWC45325.1 - 0.27 11.2 1.8 0.48 10.4 0.2 2.0 2 0 0 2 2 2 0 Ribosome biogenesis protein Nop16 YrhC PF14143.6 EWC45325.1 - 0.36 10.9 0.9 0.94 9.6 0.0 2.1 2 0 0 2 2 2 0 YrhC-like protein Ras PF00071.22 EWC45326.1 - 1.4e-32 112.5 0.6 2.3e-32 111.8 0.6 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC45326.1 - 6.4e-25 87.7 0.5 2e-24 86.1 0.1 1.9 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC45326.1 - 2.8e-07 30.1 0.1 3.9e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EWC45326.1 - 2.4e-05 23.8 0.6 3.4e-05 23.3 0.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 EWC45326.1 - 0.0011 17.9 0.5 0.14 11.0 0.0 2.2 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) EnY2 PF10163.9 EWC45327.1 - 1.2e-16 60.9 0.2 1.7e-16 60.3 0.2 1.3 1 0 0 1 1 1 1 Transcription factor e(y)2 CSTF1_dimer PF16699.5 EWC45327.1 - 0.099 12.4 0.1 0.67 9.8 0.0 2.2 2 0 0 2 2 2 0 Cleavage stimulation factor subunit 1, dimerisation domain CAF1C_H4-bd PF12265.8 EWC45328.1 - 1e-16 60.9 0.0 7.6e-16 58.1 0.0 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EWC45328.1 - 1.1e-16 60.9 8.0 3.1e-06 27.8 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC45328.1 - 3.2e-07 30.6 0.3 0.018 15.3 0.1 3.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EWC45328.1 - 0.0017 18.3 0.2 3 7.7 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EWC45328.1 - 0.14 11.1 0.0 8.1 5.3 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Astro_capsid_p PF12226.8 EWC45328.1 - 2.1 7.4 8.5 3.4 6.7 8.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PalH PF08733.10 EWC45329.1 - 3.8e-96 322.0 2.5 4.8e-96 321.6 2.5 1.1 1 0 0 1 1 1 1 PalH/RIM21 DUF1345 PF07077.11 EWC45329.1 - 0.67 9.6 3.7 15 5.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) DUF3169 PF11368.8 EWC45329.1 - 1.4 8.3 5.3 0.17 11.4 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Fungal_trans PF04082.18 EWC45330.1 - 3.4e-21 75.5 0.1 8.2e-21 74.2 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EWC45330.1 - 1.6e-08 34.5 13.0 0.00059 20.2 4.0 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC45330.1 - 1.7e-08 34.5 9.9 1.4e-06 28.4 6.5 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC45330.1 - 0.00073 20.2 18.5 0.012 16.4 3.6 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger Auts2 PF15336.6 EWC45330.1 - 0.015 15.4 0.1 0.015 15.4 0.1 3.6 3 0 0 3 3 3 0 Autism susceptibility gene 2 protein zf-C2H2_6 PF13912.6 EWC45330.1 - 0.49 10.5 11.1 0.15 12.1 3.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger PLAC8 PF04749.17 EWC45331.1 - 1.5e-21 77.2 13.3 2.3e-21 76.6 13.3 1.3 1 0 0 1 1 1 1 PLAC8 family HSP70 PF00012.20 EWC45332.1 - 6.9e-13 47.6 0.1 3.7e-11 41.9 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein EphA2_TM PF14575.6 EWC45333.1 - 0.045 14.6 0.0 0.081 13.8 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1088 PF06469.11 EWC45334.1 - 0.067 12.9 0.4 0.81 9.3 0.1 2.4 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1088) TRAM_LAG1_CLN8 PF03798.16 EWC45335.1 - 2.3e-34 118.9 22.8 2.3e-34 118.9 22.8 2.0 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.11 EWC45335.1 - 1.1e-17 63.4 0.2 2.8e-17 62.1 0.2 1.7 1 0 0 1 1 1 1 TRAM1-like protein MCM PF00493.23 EWC45337.1 - 1.6e-103 344.6 0.2 2.4e-103 344.0 0.2 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EWC45337.1 - 3.9e-38 130.1 0.5 8e-38 129.1 0.5 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EWC45337.1 - 8.3e-34 116.1 0.1 2.6e-33 114.5 0.1 1.9 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EWC45337.1 - 2.6e-26 91.8 1.3 6.7e-26 90.5 1.3 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EWC45337.1 - 2.9e-22 79.2 0.4 1.3e-21 77.1 0.4 2.2 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EWC45337.1 - 2e-07 30.6 0.0 2.2e-06 27.2 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EWC45337.1 - 0.0012 18.6 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EWC45337.1 - 0.0051 16.7 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EWC45337.1 - 0.0053 16.8 0.0 0.018 15.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) GIDA_assoc PF13932.6 EWC45337.1 - 0.023 14.9 0.9 0.053 13.7 0.9 1.5 1 0 0 1 1 1 0 GidA associated domain Rpp20 PF12328.8 EWC45339.1 - 2.3e-28 98.9 8.8 6e-28 97.5 8.8 1.6 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EWC45339.1 - 1.8e-12 46.9 0.6 3.4e-12 46.0 0.2 1.6 2 0 0 2 2 2 1 Alba HJURP_mid PF12346.8 EWC45339.1 - 0.0051 17.3 0.2 0.0093 16.4 0.2 1.4 1 0 0 1 1 1 1 Holliday junction recognition protein-associated repeat zf-C3HC4_2 PF13923.6 EWC45340.1 - 1.3e-09 37.8 9.2 1.3e-09 37.8 9.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC45340.1 - 7.9e-09 35.4 8.1 7.9e-09 35.4 8.1 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EWC45340.1 - 1.2e-08 34.7 13.3 1.5e-08 34.4 9.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC45340.1 - 1.2e-07 31.4 6.6 1.2e-07 31.4 6.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC45340.1 - 3.4e-07 30.1 9.9 3.4e-07 30.1 9.9 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EWC45340.1 - 1.2e-06 28.6 9.6 1.2e-06 28.6 9.6 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EWC45340.1 - 3.3e-06 27.3 8.7 3.3e-06 27.3 8.7 2.2 2 0 0 2 2 2 1 Ring finger domain U-box PF04564.15 EWC45340.1 - 3.3e-05 24.0 0.0 0.00014 22.0 0.0 2.0 2 0 0 2 2 2 1 U-box domain Prok-RING_4 PF14447.6 EWC45340.1 - 4.5e-05 23.2 12.1 0.00013 21.8 8.0 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EWC45340.1 - 0.0003 20.8 3.9 0.0003 20.8 3.9 1.8 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EWC45340.1 - 0.0014 18.9 7.3 0.0014 18.9 7.3 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 EWC45340.1 - 0.0047 16.8 2.2 0.0047 16.8 2.2 2.3 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EWC45340.1 - 0.0067 16.2 2.5 0.0067 16.2 2.5 2.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 EWC45340.1 - 0.19 11.6 3.1 1.4 8.9 0.5 2.7 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-Nse PF11789.8 EWC45340.1 - 1.8 8.5 7.7 0.18 11.7 2.8 1.9 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zinc-ribbons_6 PF07191.12 EWC45340.1 - 2.3 8.3 9.2 2.6 8.1 5.2 2.3 2 0 0 2 2 2 0 zinc-ribbons zf-P11 PF03854.14 EWC45340.1 - 6.9 6.4 9.1 1.9 8.2 4.1 2.2 2 0 0 2 2 2 0 P-11 zinc finger Snf7 PF03357.21 EWC45341.1 - 5.6e-19 68.4 23.4 8.7e-19 67.8 23.4 1.3 1 0 0 1 1 1 1 Snf7 Lbh PF15317.6 EWC45341.1 - 0.11 13.4 5.3 0.31 11.9 5.3 1.8 1 0 0 1 1 1 0 Cardiac transcription factor regulator, Developmental protein Ead_Ea22 PF13935.6 EWC45341.1 - 0.16 12.6 7.4 0.32 11.6 7.4 1.5 1 1 0 1 1 1 0 Ead/Ea22-like protein UPF0184 PF03670.13 EWC45341.1 - 0.22 11.9 2.8 1.6 9.1 0.3 2.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) Troponin PF00992.20 EWC45341.1 - 3.8 7.8 17.3 0.31 11.3 9.9 2.4 2 0 0 2 2 2 0 Troponin Nsp1_C PF05064.13 EWC45341.1 - 3.9 7.3 10.8 0.32 10.8 1.5 3.5 2 1 1 4 4 4 0 Nsp1-like C-terminal region TRAPPC-Trs85 PF12739.7 EWC45343.1 - 5.8e-114 381.2 0.1 5.5e-113 378.0 0.0 1.9 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF3146 PF11344.8 EWC45343.1 - 0.073 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) FtsL PF04999.13 EWC45344.1 - 0.21 11.6 0.3 0.36 10.9 0.3 1.4 1 0 0 1 1 1 0 Cell division protein FtsL PolyA_pol PF01743.20 EWC45345.1 - 1.9e-16 60.6 0.0 3.6e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EWC45345.1 - 0.0003 20.5 0.0 0.0007 19.3 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A PPR_2 PF13041.6 EWC45346.1 - 1.3e-40 137.4 11.1 3.2e-10 40.0 0.0 11.0 10 2 2 12 12 12 7 PPR repeat family PPR_3 PF13812.6 EWC45346.1 - 1.2e-24 86.1 4.6 2e-05 24.6 0.0 9.8 8 1 3 11 11 11 7 Pentatricopeptide repeat domain PPR PF01535.20 EWC45346.1 - 2.6e-20 71.2 17.3 0.00051 20.1 0.1 12.7 14 1 0 14 14 14 4 PPR repeat PPR_long PF17177.4 EWC45346.1 - 2.5e-16 59.7 14.7 2.8e-10 39.9 0.1 6.1 2 2 2 5 5 5 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EWC45346.1 - 2.2e-14 52.8 2.7 4.8e-05 23.0 0.0 7.5 9 0 0 9 9 9 2 PPR repeat RPM2 PF08579.11 EWC45346.1 - 1.6e-06 28.5 0.1 0.0013 19.2 0.1 2.9 2 0 0 2 2 2 2 Mitochondrial ribonuclease P subunit (RPM2) TPR_16 PF13432.6 EWC45346.1 - 0.0022 18.6 6.7 0.24 12.1 0.5 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC45346.1 - 0.24 11.7 3.4 23 5.4 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Tti2 PF10521.9 EWC45348.1 - 4.4e-52 177.4 0.0 5.8e-52 177.0 0.0 1.1 1 0 0 1 1 1 1 Tti2 family TetR_C_35 PF18556.1 EWC45348.1 - 0.04 14.1 0.1 0.32 11.1 0.0 2.5 1 1 1 2 2 2 0 Bacterial Tetracyclin repressor, C-terminal domain TRI5 PF06330.11 EWC45348.1 - 0.076 11.9 0.0 0.14 11.0 0.0 1.4 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) Herpes_TAF50 PF03326.13 EWC45348.1 - 0.11 11.1 0.2 0.16 10.6 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Glyco_hydro_125 PF06824.11 EWC45349.1 - 4.9e-174 579.1 0.0 5.8e-174 578.9 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) DnaJ PF00226.31 EWC45350.1 - 7.1e-16 58.1 0.0 1.3e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain FAD_binding_3 PF01494.19 EWC45351.1 - 1.3e-17 64.1 0.5 3.2e-09 36.5 0.1 3.1 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 EWC45351.1 - 2e-05 24.3 0.0 0.00013 21.7 0.0 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EWC45351.1 - 7.7e-05 21.9 0.0 0.00014 21.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EWC45351.1 - 0.00054 18.8 0.0 0.00077 18.3 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 EWC45351.1 - 0.0021 17.5 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EWC45351.1 - 0.0023 17.2 0.1 0.01 15.1 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EWC45351.1 - 0.0026 17.1 0.0 0.0054 16.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EWC45351.1 - 0.0045 17.5 0.0 0.0087 16.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EWC45351.1 - 0.0087 16.3 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EWC45351.1 - 0.034 13.2 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EWC45351.1 - 0.038 13.0 0.0 0.064 12.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EWC45351.1 - 0.074 12.3 0.0 0.19 11.0 0.0 1.9 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain mRNA_decap_C PF16741.5 EWC45351.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus Amino_oxidase PF01593.24 EWC45351.1 - 0.15 11.3 0.0 0.32 10.2 0.0 1.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase F-box-like PF12937.7 EWC45353.1 - 5.5e-07 29.4 2.7 1e-06 28.5 0.8 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EWC45353.1 - 0.00098 18.9 0.1 0.0028 17.5 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EWC45353.1 - 0.071 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 F-box RNase_T PF00929.24 EWC45354.1 - 6.3e-19 69.1 0.0 9.1e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EWC45354.1 - 0.0031 17.2 0.0 0.0077 15.9 0.0 1.6 1 1 0 1 1 1 1 3'-5' exonuclease MOR2-PAG1_N PF14222.6 EWC45356.1 - 3.9e-195 650.0 0.0 6e-195 649.4 0.0 1.3 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EWC45356.1 - 4.4e-90 302.0 0.6 9.6e-90 300.9 0.0 2.0 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EWC45356.1 - 1.5e-45 155.4 2.4 3.8e-21 74.6 0.0 4.0 3 1 0 3 3 3 3 Cell morphogenesis central region HEAT_2 PF13646.6 EWC45356.1 - 0.031 14.6 0.7 5.2 7.5 0.0 5.0 7 1 0 7 7 7 0 HEAT repeats SRP72 PF08492.12 EWC45356.1 - 0.055 13.9 0.1 0.16 12.4 0.1 1.7 1 0 0 1 1 1 0 SRP72 RNA-binding domain HEAT PF02985.22 EWC45356.1 - 0.12 12.7 1.7 1.1e+02 3.4 0.0 5.3 6 0 0 6 6 6 0 HEAT repeat FAD_binding_1 PF00667.20 EWC45357.1 - 5.8e-63 212.4 0.0 1e-62 211.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EWC45357.1 - 6.9e-34 117.1 1.0 1.3e-33 116.3 1.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EWC45357.1 - 6.6e-21 75.0 0.0 2e-20 73.5 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain RRM_1 PF00076.22 EWC45358.1 - 2.4e-24 84.9 0.0 3e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EWC45358.1 - 0.012 15.8 0.0 4.9 7.4 0.0 2.2 2 0 0 2 2 2 0 BRCA1-associated protein 2 RRM_7 PF16367.5 EWC45358.1 - 0.064 13.4 0.0 6.2 7.0 0.0 2.8 2 2 0 2 2 2 0 RNA recognition motif RIO1 PF01163.22 EWC45359.1 - 2.4e-47 161.0 0.0 3.4e-47 160.5 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 EWC45359.1 - 2.9e-33 113.9 0.0 6.9e-33 112.7 0.0 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EWC45359.1 - 1.8e-10 41.2 1.7 0.00022 21.2 0.4 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EWC45359.1 - 5.4e-08 32.4 0.2 0.0079 15.6 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family NUDIX PF00293.28 EWC45360.1 - 4.4e-29 101.2 0.0 6.6e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Acetyltransf_7 PF13508.7 EWC45361.1 - 1.1e-05 25.8 0.0 1.7e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EWC45361.1 - 0.00011 22.4 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC45361.1 - 0.0002 21.3 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EWC45361.1 - 0.0075 16.3 0.0 0.086 12.9 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EWC45361.1 - 0.19 11.7 0.0 0.58 10.2 0.0 1.7 2 0 0 2 2 2 0 FR47-like protein Syja_N PF02383.18 EWC45362.1 - 8e-75 252.1 0.0 1.5e-74 251.2 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Mlh1_C PF16413.5 EWC45363.1 - 3.1e-91 305.5 0.1 5.7e-91 304.6 0.1 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EWC45363.1 - 1.1e-34 118.7 0.2 1.8e-34 118.0 0.2 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EWC45363.1 - 2.7e-12 46.7 0.1 5.2e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EWC45363.1 - 2.2e-07 31.4 0.0 5.1e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TFIIS_C PF01096.18 EWC45364.1 - 8.1e-16 57.6 1.2 1e-15 57.2 1.2 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) DUF3716 PF12511.8 EWC45364.1 - 0.0034 17.4 0.2 0.0044 17.0 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Terminase_GpA PF05876.12 EWC45364.1 - 0.0047 15.6 0.1 0.0047 15.6 0.1 1.0 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) zf-H2C2_2 PF13465.6 EWC45364.1 - 0.01 16.2 3.1 0.12 12.8 0.5 2.4 2 1 0 2 2 2 0 Zinc-finger double domain Baculo_LEF5_C PF11792.8 EWC45364.1 - 0.012 15.3 0.1 0.018 14.7 0.1 1.4 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain DZR PF12773.7 EWC45364.1 - 0.015 15.3 2.6 0.16 12.0 2.7 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EWC45364.1 - 0.016 14.6 4.4 0.63 9.5 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_7 PF02591.15 EWC45364.1 - 0.025 14.8 0.3 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 C4-type zinc ribbon domain zinc_ribbon_9 PF14369.6 EWC45364.1 - 0.035 14.4 1.3 4 7.8 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon HypA PF01155.19 EWC45364.1 - 0.066 13.2 0.1 0.087 12.9 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ogr_Delta PF04606.12 EWC45364.1 - 0.15 12.0 4.0 0.32 11.0 4.0 1.6 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger zf-Mss51 PF13824.6 EWC45364.1 - 0.2 11.8 3.2 1.9 8.6 3.2 2.0 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf_UBZ PF18439.1 EWC45364.1 - 0.2 11.3 2.3 9.2 6.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Anti-TRAP PF15777.5 EWC45364.1 - 0.21 11.6 1.6 0.66 10.0 1.6 1.8 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF1610 PF07754.11 EWC45364.1 - 0.25 11.4 0.6 0.25 11.4 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-C2H2 PF00096.26 EWC45364.1 - 0.28 11.7 5.0 1.4 9.5 1.4 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC45364.1 - 0.87 10.6 3.6 12 7.0 0.7 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Auto_anti-p27 PF06677.12 EWC45364.1 - 0.9 9.8 6.3 31 4.8 6.8 2.1 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zinc_ribbon_4 PF13717.6 EWC45364.1 - 1.2 9.1 4.9 2.9 7.9 1.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EWC45364.1 - 1.4 9.1 6.4 4.8 7.4 0.9 2.2 1 1 1 2 2 2 0 Zinc ribbon domain zf-HIT PF04438.16 EWC45364.1 - 2.8 7.9 10.1 0.48 10.3 3.6 2.1 2 0 0 2 2 2 0 HIT zinc finger UPF0547 PF10571.9 EWC45364.1 - 6.1 7.0 7.9 7.3 6.8 2.6 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 HEAT_2 PF13646.6 EWC45365.1 - 1.1e-28 99.4 3.8 1.8e-11 44.2 0.6 4.1 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.16 EWC45365.1 - 4.1e-20 70.4 0.5 0.011 16.3 0.2 6.9 8 0 0 8 8 8 4 PBS lyase HEAT-like repeat HEAT PF02985.22 EWC45365.1 - 9e-10 38.0 5.6 0.044 14.1 0.0 7.1 8 0 0 8 8 8 2 HEAT repeat Cnd1 PF12717.7 EWC45365.1 - 0.00044 20.3 0.5 0.62 10.1 0.0 4.0 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EWC45365.1 - 0.00065 20.1 2.7 9.8 6.8 0.1 5.4 5 1 1 6 6 6 1 HEAT-like repeat Hamartin PF04388.12 EWC45366.1 - 6.4e-28 97.9 25.5 6.4e-28 97.9 25.5 3.5 1 1 0 2 2 2 1 Hamartin protein DUF1189 PF06691.11 EWC45366.1 - 0.065 12.8 0.7 0.12 11.9 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Sec20 PF03908.13 EWC45366.1 - 3 7.8 10.2 2.5 8.1 1.2 2.9 3 0 0 3 3 3 0 Sec20 PAPS_reduct PF01507.19 EWC45367.1 - 3e-25 89.3 0.0 2.5e-18 66.7 0.0 3.5 2 1 0 2 2 2 2 Phosphoadenosine phosphosulfate reductase family Helicase_C PF00271.31 EWC45367.1 - 6.8e-10 39.3 0.0 1.7e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SUV3_C PF12513.8 EWC45367.1 - 7.5e-09 35.4 0.2 1.6e-08 34.3 0.2 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 EWC45367.1 - 0.043 13.7 0.0 0.099 12.5 0.0 1.7 1 0 0 1 1 1 0 Suv3 C-terminal domain 1 Sec1 PF00995.23 EWC45368.1 - 1.9e-99 334.5 0.0 2.2e-99 334.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family BTB PF00651.31 EWC45369.1 - 9.8e-07 29.0 0.1 2.8e-06 27.5 0.1 1.7 1 1 0 1 1 1 1 BTB/POZ domain DIM1 PF02966.16 EWC45370.1 - 9.4e-69 229.3 0.5 1.1e-68 229.1 0.5 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EWC45370.1 - 0.056 13.4 0.0 0.072 13.1 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin RNase_H2_suC PF08615.11 EWC45371.1 - 8.1e-24 84.4 0.0 9.3e-24 84.2 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Ank_4 PF13637.6 EWC45372.1 - 0.00011 22.7 0.5 0.21 12.2 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) MVP_shoulder PF11978.8 EWC45372.1 - 0.052 13.6 0.3 1.6 8.8 0.5 2.6 2 0 0 2 2 2 0 Shoulder domain Ank_5 PF13857.6 EWC45372.1 - 0.2 12.0 1.4 2.9 8.3 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Helo_like_N PF17111.5 EWC45373.1 - 1.2e-05 24.8 2.2 1.9e-05 24.1 0.1 2.5 3 0 0 3 3 3 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EWC45373.1 - 0.00011 22.4 0.4 0.00034 20.8 0.4 1.9 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Rx_N PF18052.1 EWC45373.1 - 0.0045 17.2 0.1 0.0045 17.2 0.1 3.1 3 0 0 3 3 3 1 Rx N-terminal domain Goodbye PF17109.5 EWC45373.1 - 0.0086 16.5 0.2 0.041 14.3 0.1 2.2 3 0 0 3 3 3 1 fungal STAND N-terminal Goodbye domain NPV_P10 PF05531.12 EWC45373.1 - 0.14 12.7 1.8 26 5.3 0.0 3.9 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Ank_4 PF13637.6 EWC45373.1 - 0.14 12.8 0.0 2.3 8.9 0.0 2.5 1 1 1 2 2 2 0 Ankyrin repeats (many copies) MtrB PF05440.12 EWC45373.1 - 0.17 12.3 0.0 0.5 10.8 0.0 1.8 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B Laminin_II PF06009.12 EWC45373.1 - 0.19 11.8 6.3 0.84 9.6 0.6 3.3 2 1 1 3 3 3 0 Laminin Domain II DHR10 PF18595.1 EWC45373.1 - 0.43 10.6 0.1 0.43 10.6 0.1 2.9 5 1 0 5 5 5 0 Designed helical repeat protein 10 domain DEAD PF00270.29 EWC45374.1 - 2.1e-47 161.2 0.1 5.1e-46 156.6 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC45374.1 - 7.8e-25 87.4 0.0 2.4e-24 85.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EWC45374.1 - 1.3e-21 76.6 2.4 1.3e-21 76.6 2.4 2.3 2 0 0 2 2 2 1 DBP10CT (NUC160) domain RRM_1 PF00076.22 EWC45375.1 - 1.6e-26 91.9 0.1 9.8e-13 47.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EWC45375.1 - 0.00069 19.2 0.0 0.018 14.6 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EWC45375.1 - 0.028 14.5 0.1 0.1 12.7 0.0 2.0 2 0 0 2 2 2 0 Limkain b1 RRM_8 PF11835.8 EWC45375.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 RRM-like domain RPA_C PF08784.11 EWC45376.1 - 7e-17 62.0 0.2 7e-17 62.0 0.2 2.5 3 0 0 3 3 3 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EWC45376.1 - 0.0013 18.7 0.2 0.0037 17.2 0.1 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 EWC45376.1 - 0.0031 17.3 0.0 0.018 14.8 0.0 1.9 2 0 0 2 2 2 1 RecQ-mediated genome instability protein 2 Keratin_2_head PF16208.5 EWC45376.1 - 0.68 10.1 20.6 1 9.5 14.7 2.2 2 0 0 2 2 2 0 Keratin type II head Ribosomal_L23 PF00276.20 EWC45377.1 - 4.1e-08 33.5 0.0 7.4e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 PRE_C2HC PF07530.11 EWC45377.1 - 0.03 14.4 0.1 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Associated with zinc fingers Glyco_transf_8 PF01501.20 EWC45378.1 - 3.4e-13 49.7 1.0 2.1e-12 47.1 1.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 EWC45378.1 - 0.019 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Glucosyltransferase 24 Nucleotid_trans PF03407.16 EWC45378.1 - 0.078 12.9 0.8 0.13 12.2 0.8 1.5 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase ETRAMP PF09716.10 EWC45378.1 - 0.24 11.5 0.3 0.46 10.6 0.0 1.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Pyr_redox_2 PF07992.14 EWC45379.1 - 2.3e-41 142.0 0.0 3.3e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EWC45379.1 - 3.7e-12 46.6 0.0 6.3e-10 39.5 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EWC45379.1 - 1.3e-05 24.4 0.1 3.1e-05 23.2 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EWC45379.1 - 7e-05 22.4 0.3 0.00023 20.8 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 EWC45379.1 - 0.00015 21.1 0.1 0.00033 20.0 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EWC45379.1 - 0.0016 18.9 0.0 0.0061 17.0 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.7 EWC45379.1 - 0.11 12.4 0.1 0.36 10.8 0.0 1.8 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand IL11 PF07400.11 EWC45379.1 - 0.23 11.1 4.9 0.6 9.7 0.3 2.6 3 0 0 3 3 3 0 Interleukin 11 PetL PF05115.14 EWC45379.1 - 0.54 10.3 3.0 1.2 9.2 3.0 1.5 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit VI (PetL) Pyr_redox_3 PF13738.6 EWC45379.1 - 2.3 7.4 4.0 44 3.2 3.0 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase G-patch PF01585.23 EWC45380.1 - 1.9e-10 40.4 1.7 3.6e-10 39.6 1.7 1.5 1 0 0 1 1 1 1 G-patch domain zf-C2H2_2 PF12756.7 EWC45380.1 - 0.11 12.8 0.4 0.22 11.9 0.2 1.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) PNP_phzG_C PF10590.9 EWC45381.1 - 9e-20 70.5 1.6 4.8e-19 68.1 1.3 2.3 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EWC45381.1 - 5e-16 58.7 0.0 8.1e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 EWC45381.1 - 0.0014 19.2 0.1 0.0033 18.0 0.1 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Ribosomal_S2 PF00318.20 EWC45381.1 - 0.087 12.0 0.1 0.16 11.1 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein S2 CDC27 PF09507.10 EWC45382.1 - 1.3e-73 248.8 26.0 1.6e-73 248.6 26.0 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 CDC45 PF02724.14 EWC45382.1 - 3.2 5.9 10.8 4.8 5.3 10.8 1.2 1 0 0 1 1 1 0 CDC45-like protein MOZ_SAS PF01853.18 EWC45383.1 - 3.4e-81 271.2 0.1 6.1e-81 270.4 0.1 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EWC45383.1 - 1.6e-23 82.0 2.0 4.5e-23 80.6 2.0 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EWC45383.1 - 2.2e-21 75.5 0.1 4.8e-21 74.4 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EWC45383.1 - 0.0074 16.7 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain IF2_N PF04760.15 EWC45383.1 - 0.02 14.7 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Acetyltransf_1 PF00583.25 EWC45383.1 - 0.058 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HTH_Mga PF08280.11 EWC45383.1 - 0.079 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Patatin PF01734.22 EWC45384.1 - 1.5e-14 54.6 0.0 6.9e-14 52.5 0.0 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase Ribonuc_L-PSP PF01042.21 EWC45386.1 - 5.4e-39 132.9 0.0 6e-39 132.8 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP MFS_1 PF07690.16 EWC45388.1 - 1.4e-27 96.6 32.0 1.4e-27 96.6 32.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DnaJ PF00226.31 EWC45389.1 - 2.4e-13 50.0 2.0 4.7e-13 49.1 0.2 2.3 2 1 0 2 2 2 1 DnaJ domain DEAD PF00270.29 EWC45390.1 - 4.1e-48 163.5 0.0 8.8e-48 162.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC45390.1 - 5.6e-25 87.8 0.1 2.9e-24 85.6 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EWC45390.1 - 3.8e-20 71.9 0.0 9.1e-20 70.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EWC45390.1 - 1e-06 28.9 0.0 1e-06 28.9 0.0 2.9 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 EWC45390.1 - 0.032 14.4 0.0 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 Helicase C-terminal domain DUF3337 PF11816.8 EWC45391.1 - 2.8e-53 180.3 0.0 5e-53 179.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EWC45391.1 - 6.1e-16 58.5 16.8 0.0002 22.1 0.1 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC45391.1 - 0.0058 16.9 0.1 0.12 12.7 0.1 2.7 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC45391.1 - 0.0066 15.1 0.1 0.014 14.1 0.1 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EWC45391.1 - 0.03 13.3 0.1 0.12 11.3 0.0 1.8 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Anp1 PF03452.14 EWC45392.1 - 2.2e-111 371.5 0.0 3.3e-111 370.9 0.0 1.3 1 0 0 1 1 1 1 Anp1 Glyco_tranf_2_4 PF13704.6 EWC45392.1 - 0.13 12.7 0.2 0.38 11.3 0.2 1.8 1 0 0 1 1 1 0 Glycosyl transferase family 2 Casc1_N PF15927.5 EWC45392.1 - 7.9 6.1 14.5 17 5.0 14.5 1.5 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Sec7 PF01369.20 EWC45393.1 - 2.9e-64 216.1 0.0 4.9e-64 215.4 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EWC45393.1 - 6.9e-19 68.3 0.0 3.9e-18 65.9 0.0 2.4 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Pilosulin PF17499.2 EWC45393.1 - 0.031 14.5 0.0 0.071 13.3 0.0 1.6 1 0 0 1 1 1 0 Ant venom peptides AAA_6 PF12774.7 EWC45394.1 - 1.1e-126 422.3 0.4 5.5e-125 416.7 0.0 3.1 3 0 0 3 3 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 EWC45394.1 - 2.6e-126 422.5 2.6 2.6e-126 422.5 2.6 4.3 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EWC45394.1 - 1.5e-116 389.8 7.3 1.5e-116 389.8 7.3 5.4 6 2 0 7 7 6 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EWC45394.1 - 9.2e-74 247.3 0.7 9.2e-74 247.3 0.7 4.7 4 1 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 EWC45394.1 - 8.6e-65 218.6 0.0 2e-63 214.2 0.0 2.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EWC45394.1 - 2.2e-42 144.6 0.1 2.4e-36 124.9 0.0 5.0 6 0 0 6 6 6 2 P-loop containing dynein motor region MT PF12777.7 EWC45394.1 - 9.8e-37 126.8 3.5 9.8e-37 126.8 3.5 2.7 4 0 0 4 4 3 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EWC45394.1 - 6.2e-31 107.2 0.1 3.8e-12 46.4 0.0 7.2 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 EWC45394.1 - 3.3e-29 101.4 0.0 2.2e-24 85.8 0.0 4.5 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EWC45394.1 - 1.8e-27 96.2 0.0 5e-27 94.7 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 EWC45394.1 - 2.2e-16 60.1 0.0 8.9e-16 58.1 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EWC45394.1 - 1e-14 55.0 0.9 0.01 16.1 0.0 6.5 5 1 1 6 6 5 3 AAA domain AAA PF00004.29 EWC45394.1 - 2e-14 54.1 0.0 0.0016 18.9 0.0 5.3 5 0 0 5 5 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC45394.1 - 4.7e-11 43.4 0.3 1.8 8.9 0.0 7.2 7 0 0 7 7 5 2 AAA ATPase domain AAA_33 PF13671.6 EWC45394.1 - 2.6e-09 37.4 0.1 0.37 10.9 0.0 5.3 4 0 0 4 4 4 3 AAA domain AAA_18 PF13238.6 EWC45394.1 - 7.8e-09 36.2 0.7 0.084 13.4 0.0 6.2 6 0 0 6 6 5 2 AAA domain ABC_tran PF00005.27 EWC45394.1 - 1e-05 26.1 0.0 0.49 10.9 0.0 4.7 3 0 0 3 3 3 1 ABC transporter T2SSE PF00437.20 EWC45394.1 - 2.2e-05 23.7 0.0 0.027 13.6 0.0 3.5 3 0 0 3 3 3 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EWC45394.1 - 3.5e-05 23.3 0.0 1.5 8.1 0.0 3.7 3 0 0 3 3 3 2 FtsK/SpoIIIE family AAA_29 PF13555.6 EWC45394.1 - 4.1e-05 23.2 0.1 2.3 8.0 0.0 3.7 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_lid_1 PF17857.1 EWC45394.1 - 8e-05 22.8 0.4 0.0047 17.1 0.0 3.6 3 0 0 3 3 3 1 AAA+ lid domain Mg_chelatase PF01078.21 EWC45394.1 - 0.00023 20.6 0.9 0.66 9.3 0.0 3.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EWC45394.1 - 0.00027 20.7 0.1 40 3.9 0.0 4.8 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 EWC45394.1 - 0.00054 20.3 0.8 0.28 11.5 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.6 EWC45394.1 - 0.002 17.7 0.0 0.23 11.0 0.0 3.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EWC45394.1 - 0.0027 17.7 0.0 7.7 6.4 0.1 3.6 3 0 0 3 3 3 0 RsgA GTPase RNA_helicase PF00910.22 EWC45394.1 - 0.0028 18.0 0.2 17 5.9 0.0 5.3 6 0 0 6 6 5 0 RNA helicase AAA_24 PF13479.6 EWC45394.1 - 0.005 16.6 3.0 10 5.8 0.0 4.9 5 0 0 5 5 4 0 AAA domain IstB_IS21 PF01695.17 EWC45394.1 - 0.0069 16.1 0.3 0.82 9.4 0.0 3.8 4 0 0 4 4 4 1 IstB-like ATP binding protein Zeta_toxin PF06414.12 EWC45394.1 - 0.027 13.8 0.0 11 5.2 0.1 3.8 3 0 0 3 3 3 0 Zeta toxin Rad17 PF03215.15 EWC45394.1 - 0.054 13.4 0.1 7 6.5 0.0 3.8 4 0 0 4 4 3 0 Rad17 P-loop domain TraF_2 PF13729.6 EWC45394.1 - 0.12 11.8 0.4 1.4 8.2 0.0 2.6 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein HD_3 PF13023.6 EWC45394.1 - 0.26 11.2 2.8 1.1 9.2 0.9 3.0 2 0 0 2 2 2 0 HD domain CdiI PF07262.11 EWC45394.1 - 0.28 10.9 1.9 2 8.2 0.0 3.2 3 0 0 3 3 2 0 CDI immunity protein Phage_GP20 PF06810.11 EWC45394.1 - 0.38 10.5 23.7 1.2 9.0 0.2 4.2 4 0 0 4 4 3 0 Phage minor structural protein GP20 NACHT PF05729.12 EWC45394.1 - 1.9 8.4 7.3 33 4.4 0.1 4.5 4 0 0 4 4 3 0 NACHT domain MbeB_N PF04837.12 EWC45394.1 - 3.2 8.1 11.1 0.53 10.6 0.1 4.1 3 0 0 3 3 2 0 MbeB-like, N-term conserved region tRNA_bind PF01588.20 EWC45395.1 - 3.9e-27 94.2 0.0 8.2e-27 93.2 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EWC45395.1 - 0.0025 17.8 0.0 0.0055 16.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain IHABP4_N PF16174.5 EWC45395.1 - 0.13 12.9 10.0 0.23 12.0 10.0 1.4 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal GST_C PF00043.25 EWC45395.1 - 0.17 12.1 0.0 0.68 10.2 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Acetyltransf_7 PF13508.7 EWC45396.1 - 1.9e-05 25.0 0.0 3.9e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EWC45396.1 - 0.0067 16.7 0.1 0.24 11.6 0.0 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EWC45396.1 - 0.0079 16.3 0.5 0.042 13.9 0.2 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EWC45396.1 - 0.08 12.9 0.0 0.32 11.0 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Nuf2 PF03800.14 EWC45397.1 - 6e-35 120.4 0.1 1.4e-34 119.2 0.1 1.7 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 EWC45397.1 - 5.7e-28 97.3 19.7 5.7e-28 97.3 19.7 4.1 3 1 0 3 3 3 1 Designed helical repeat protein 10 domain DUF948 PF06103.11 EWC45397.1 - 0.38 11.0 3.9 6.5 7.1 0.1 3.7 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) HALZ PF02183.18 EWC45397.1 - 1.9 8.8 14.6 3.5 7.9 0.2 4.6 4 1 0 4 4 4 0 Homeobox associated leucine zipper DUF4600 PF15372.6 EWC45397.1 - 2 8.9 31.9 0.051 14.0 7.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) Meth_synt_2 PF01717.18 EWC45398.1 - 3.1e-13 49.7 0.0 1.1e-10 41.3 0.0 2.1 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EWC45398.1 - 0.057 12.9 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain Nramp PF01566.18 EWC45399.1 - 7.5e-88 294.9 18.1 4.8e-87 292.3 18.1 2.0 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein Spem1 PF15670.5 EWC45400.1 - 0.38 10.3 3.3 0.97 9.0 3.3 1.7 1 0 0 1 1 1 0 Spermatid maturation protein 1 RNA_pol_N PF01194.17 EWC45401.1 - 0.043 14.1 0.0 0.12 12.7 0.0 1.8 2 0 0 2 2 2 0 RNA polymerases N / 8 kDa subunit APH PF01636.23 EWC45402.1 - 9.8e-11 42.0 0.3 1.4e-10 41.5 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Mito_carr PF00153.27 EWC45403.1 - 4.3e-60 199.7 3.5 4.1e-23 81.1 0.2 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 EWC45403.1 - 0.015 14.4 0.1 0.43 9.7 0.0 2.3 2 0 0 2 2 2 0 Gammaproteobacterial serine protease SRTM1 PF15872.5 EWC45403.1 - 0.11 12.7 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 PT-VENN PF04829.13 EWC45403.1 - 1.5 9.0 7.0 3.9 7.6 0.0 3.5 4 0 0 4 4 4 0 Pre-toxin domain with VENN motif Kelch_5 PF13854.6 EWC45404.1 - 1.5e-05 24.8 6.4 3.5e-05 23.7 0.1 3.6 3 0 0 3 3 3 1 Kelch motif PTP_tm PF18861.1 EWC45404.1 - 0.0039 17.2 0.1 0.0063 16.5 0.1 1.3 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Kelch_3 PF13415.6 EWC45404.1 - 0.044 14.1 1.0 71 3.9 0.0 4.2 3 1 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 EWC45404.1 - 0.05 13.9 4.1 17 5.9 0.0 4.6 5 0 0 5 5 5 0 Kelch motif Romo1 PF10247.9 EWC45404.1 - 4.9 7.6 5.4 1.2 9.5 0.1 2.5 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 Ecm33 PF12454.8 EWC45406.1 - 0.042 14.0 2.7 0.042 14.0 2.7 2.3 1 1 2 3 3 3 0 GPI-anchored cell wall organization protein FSA_C PF10479.9 EWC45406.1 - 2.2 6.3 19.2 2.8 6.0 19.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus NIR_SIR PF01077.22 EWC45407.1 - 3.8e-53 179.2 0.0 4.6e-47 159.5 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EWC45407.1 - 4.5e-32 109.7 0.0 4.1e-15 55.4 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 EWC45407.1 - 8.1e-30 103.9 0.0 1.5e-29 103.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 EWC45407.1 - 1.6e-07 31.3 0.0 3.3e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg DUF4690 PF15756.5 EWC45408.1 - 0.00084 19.9 0.7 0.0021 18.6 0.7 1.6 1 0 0 1 1 1 1 Small Novel Rich in Cartilage VSP PF03302.13 EWC45408.1 - 0.0017 17.3 1.0 0.003 16.5 1.0 1.5 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.11 EWC45408.1 - 0.0039 17.3 1.1 0.0069 16.5 1.1 1.4 1 0 0 1 1 1 1 Podoplanin PTP_tm PF18861.1 EWC45408.1 - 0.017 15.1 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Granulin PF00396.18 EWC45408.1 - 2.8 8.3 5.3 8.8 6.8 0.8 2.9 3 0 0 3 3 3 0 Granulin Svf1_C PF17187.4 EWC45409.1 - 5.4e-61 205.2 0.0 7.4e-61 204.8 0.0 1.2 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EWC45409.1 - 4.9e-47 160.0 0.0 6.9e-47 159.5 0.0 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain UMP1 PF05348.11 EWC45410.1 - 3.7e-19 69.1 0.0 4e-19 69.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Npa1 PF11707.8 EWC45411.1 - 8.7e-100 334.4 0.0 1.1e-98 330.7 0.0 2.4 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EWC45411.1 - 2.2e-44 151.5 0.0 1.7e-43 148.6 0.0 2.3 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 DUF3246 PF11596.8 EWC45411.1 - 0.063 12.7 0.5 0.12 11.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Adaptin_binding PF10199.9 EWC45412.1 - 0.007 17.0 2.3 0.007 17.0 2.3 4.5 2 1 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 MecA PF05389.12 EWC45412.1 - 6.3 6.4 28.2 0.055 13.1 5.7 3.0 3 0 0 3 3 3 0 Negative regulator of genetic competence (MecA) BsuPI PF12690.7 EWC45413.1 - 0.094 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Intracellular proteinase inhibitor Rad60-SLD_2 PF13881.6 EWC45415.1 - 3.7e-11 43.1 0.0 4.1e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EWC45415.1 - 0.00012 21.8 0.0 0.00021 21.0 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin family DUF2407 PF10302.9 EWC45415.1 - 0.055 14.0 0.0 0.059 13.9 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain GATA PF00320.27 EWC45417.1 - 2.6e-28 97.3 17.6 1.3e-14 53.5 3.4 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EWC45417.1 - 3.5e-06 26.4 3.8 0.0087 15.6 0.1 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding zf-RRN7 PF11781.8 EWC45417.1 - 4.3e-06 26.3 4.5 0.015 15.0 0.4 2.4 2 0 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Zn-ribbon_8 PF09723.10 EWC45417.1 - 6.1e-05 23.0 1.5 0.098 12.8 0.2 2.8 2 0 0 2 2 2 2 Zinc ribbon domain ArfGap PF01412.18 EWC45417.1 - 0.00018 21.6 3.9 0.25 11.4 0.2 2.4 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf OrfB_Zn_ribbon PF07282.11 EWC45417.1 - 0.0042 17.0 5.1 0.25 11.3 0.4 2.6 2 0 0 2 2 2 2 Putative transposase DNA-binding domain Auto_anti-p27 PF06677.12 EWC45417.1 - 0.024 14.8 6.3 1.2 9.4 0.7 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 EWC45417.1 - 0.069 13.2 10.2 1.5 8.9 0.8 3.2 2 1 1 3 3 3 0 Double zinc ribbon eIF-5_eIF-2B PF01873.17 EWC45417.1 - 0.43 10.5 4.7 11 6.0 0.5 2.5 2 0 0 2 2 2 0 Domain found in IF2B/IF5 DUF2318 PF10080.9 EWC45417.1 - 0.48 10.6 2.6 1.3 9.2 0.0 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2318) Rpr2 PF04032.16 EWC45417.1 - 2.8 8.3 6.0 9.9 6.5 0.0 3.9 3 1 0 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-Sec23_Sec24 PF04810.15 EWC45417.1 - 7.9 6.6 13.6 0.11 12.6 0.6 2.9 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-C2H2_3 PF13878.6 EWC45417.1 - 9.2 6.2 6.8 20 5.1 0.1 3.5 3 1 1 4 4 4 0 zinc-finger of acetyl-transferase ESCO RsfS PF02410.15 EWC45418.1 - 4.3e-13 49.5 0.0 1.1e-12 48.2 0.0 1.7 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation DUF3153 PF11353.8 EWC45418.1 - 0.0068 16.0 0.4 0.032 13.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3153) DcpS PF05652.12 EWC45419.1 - 4.6e-35 120.6 0.0 7.7e-35 119.9 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EWC45419.1 - 1.7e-31 109.1 1.0 2.7e-31 108.4 1.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding NdhS PF11623.8 EWC45419.1 - 0.052 13.2 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S Mito_carr PF00153.27 EWC45423.1 - 9.3e-43 144.1 13.9 7.6e-19 67.4 0.4 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EWC45423.1 - 0.011 15.0 3.1 0.32 10.1 0.1 2.8 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Dcc1 PF09724.9 EWC45424.1 - 1.5e-37 129.6 0.0 1.9e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 RhoGEF PF00621.20 EWC45425.1 - 6.1e-21 75.5 0.0 2.7e-20 73.4 0.0 2.1 2 0 0 2 2 2 1 RhoGEF domain DUF3507 PF12015.8 EWC45425.1 - 0.00017 21.4 0.0 0.00033 20.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) RhoGAP PF00620.27 EWC45425.1 - 0.0019 18.0 0.0 0.0063 16.4 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain Tropomyosin_1 PF12718.7 EWC45425.1 - 0.064 13.4 1.0 0.21 11.7 1.0 1.8 1 0 0 1 1 1 0 Tropomyosin like tRNA-synt_1 PF00133.22 EWC45426.1 - 1.3e-213 710.6 0.2 2.1e-212 706.6 0.2 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EWC45426.1 - 2.1e-17 62.9 5.0 2.9e-10 39.4 0.0 4.7 4 2 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EWC45426.1 - 2.1e-14 53.7 0.7 2.1e-14 53.7 0.7 2.6 2 1 1 3 3 3 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 EWC45426.1 - 1.1e-09 38.0 5.9 4.4e-08 32.9 0.0 2.9 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EWC45426.1 - 0.03 13.7 0.0 2.7 7.2 0.0 2.6 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain PepSY PF03413.19 EWC45426.1 - 0.41 11.2 5.0 1.6 9.3 0.0 3.1 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Git3 PF11710.8 EWC45428.1 - 4.2e-61 206.2 16.5 4.2e-61 206.2 16.5 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EWC45428.1 - 6.2e-27 93.5 2.8 1.5e-26 92.2 1.7 2.2 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7TM_GPCR_Srsx PF10320.9 EWC45428.1 - 0.0072 15.7 4.0 0.012 14.9 4.0 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx HPHLAWLY PF14925.6 EWC45428.1 - 0.21 10.2 2.0 0.31 9.7 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function adh_short PF00106.25 EWC45429.1 - 4.3e-14 52.4 0.0 4e-09 36.2 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EWC45429.1 - 1.9e-06 27.9 0.0 3.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EWC45429.1 - 7.9e-05 22.3 0.0 0.0015 18.2 0.0 2.3 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EWC45429.1 - 0.026 14.0 0.0 0.18 11.3 0.0 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family HA2 PF04408.23 EWC45430.1 - 1.6e-24 86.3 0.4 6.9e-24 84.2 0.0 2.4 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EWC45430.1 - 4.8e-21 74.9 0.0 9.4e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EWC45430.1 - 2.8e-14 53.4 0.0 1e-13 51.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EWC45430.1 - 1.9e-11 44.1 1.0 3.9e-11 43.1 1.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain T2SSE PF00437.20 EWC45430.1 - 1.7e-05 24.1 0.1 3.3e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EWC45430.1 - 2.9e-05 24.4 0.1 7.8e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EWC45430.1 - 0.00022 21.0 0.6 0.00066 19.5 0.6 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EWC45430.1 - 0.00041 20.1 0.0 0.0013 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EWC45430.1 - 0.0059 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EWC45430.1 - 0.013 15.8 0.1 0.029 14.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain Microtub_bd PF16796.5 EWC45430.1 - 0.08 12.9 0.5 1.9 8.4 0.0 2.7 3 0 0 3 3 3 0 Microtubule binding AAA_14 PF13173.6 EWC45430.1 - 0.14 12.2 0.1 0.97 9.5 0.1 2.2 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EWC45430.1 - 0.43 11.1 3.5 1.5 9.3 0.1 3.1 2 1 1 3 3 3 0 ABC transporter Peptidase_C12 PF01088.21 EWC45431.1 - 1e-51 175.7 0.0 1.2e-51 175.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Ribosomal_S7 PF00177.21 EWC45432.1 - 6.5e-24 84.3 0.0 9.6e-24 83.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Nipped-B_C PF12830.7 EWC45433.1 - 4e-49 167.1 8.8 5.7e-47 160.1 0.2 4.4 5 0 0 5 5 5 2 Sister chromatid cohesion C-terminus HEAT PF02985.22 EWC45433.1 - 1.2e-09 37.6 2.1 0.0056 16.8 0.1 5.0 4 0 0 4 4 4 3 HEAT repeat Cohesin_HEAT PF12765.7 EWC45433.1 - 2.4e-08 34.1 3.3 3.4e-07 30.4 0.2 3.6 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.6 EWC45433.1 - 7.6e-06 26.2 1.1 0.018 15.4 0.1 3.9 4 0 0 4 4 4 2 HEAT repeats Cnd1 PF12717.7 EWC45433.1 - 0.0038 17.3 1.0 2 8.4 0.1 3.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EWC45433.1 - 0.0047 17.4 1.8 8.8 7.0 0.1 4.3 4 0 0 4 4 4 2 HEAT-like repeat CLASP_N PF12348.8 EWC45433.1 - 0.0063 16.1 0.0 0.041 13.4 0.0 2.4 1 0 0 1 1 1 1 CLASP N terminal Gcn1_N PF12074.8 EWC45433.1 - 0.15 11.4 1.1 3.1 7.0 0.1 3.6 4 0 0 4 4 4 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Abhydrolase_4 PF08386.10 EWC45435.1 - 4.4e-18 65.3 0.0 1e-17 64.1 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 EWC45435.1 - 2.2e-15 57.0 0.0 1.3e-12 48.0 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold AAA_25 PF13481.6 EWC45435.1 - 0.18 11.4 0.0 0.39 10.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain UPF0086 PF01868.16 EWC45436.1 - 8.2e-31 105.8 0.0 1.3e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 WD40 PF00400.32 EWC45438.1 - 1.7e-10 41.3 8.7 0.56 11.2 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ATP_bind_3 PF01171.20 EWC45440.1 - 2.5e-47 161.0 0.1 5.9e-47 159.8 0.0 1.7 2 0 0 2 2 2 1 PP-loop family NAD_synthase PF02540.17 EWC45440.1 - 0.00012 21.2 0.0 0.00021 20.5 0.0 1.3 1 0 0 1 1 1 1 NAD synthase Cullin_binding PF03556.15 EWC45441.1 - 3.5e-20 72.7 1.2 5.9e-20 71.9 0.8 1.6 1 1 0 1 1 1 1 Cullin binding Cpn10 PF00166.21 EWC45442.1 - 1.6e-26 92.2 0.0 1.8e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit PolyA_pol_RNAbd PF12627.7 EWC45442.1 - 0.034 13.9 0.5 0.12 12.1 0.5 1.9 1 1 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A Rhomboid PF01694.22 EWC45443.1 - 1e-18 67.7 6.2 1e-18 67.7 6.2 1.9 2 1 0 2 2 2 1 Rhomboid family Pam17 PF08566.10 EWC45443.1 - 0.17 11.7 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 Pkinase PF00069.25 EWC45444.1 - 7.5e-46 156.6 0.0 1.5e-45 155.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45444.1 - 1.6e-20 73.5 0.0 3e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC45444.1 - 0.013 15.4 0.2 0.025 14.5 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EWC45444.1 - 0.021 13.8 0.1 0.037 13.0 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EWC45444.1 - 0.045 13.1 0.0 0.085 12.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Ribosomal_L11 PF00298.19 EWC45445.1 - 1.3e-27 96.1 0.2 2.1e-27 95.4 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EWC45445.1 - 6.2e-26 90.0 0.1 1.1e-25 89.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Fip1 PF05182.13 EWC45447.1 - 3e-20 71.5 1.2 3e-20 71.5 1.2 1.9 2 0 0 2 2 2 1 Fip1 motif HDV_ag PF01517.18 EWC45447.1 - 0.043 13.6 0.2 0.1 12.4 0.2 1.6 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen EBV-NA3 PF05009.12 EWC45447.1 - 0.58 9.6 3.3 0.99 8.9 3.3 1.3 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Nucleoporin_FG PF13634.6 EWC45448.1 - 2.8e-24 85.8 85.9 3.4e-12 47.0 25.2 3.4 1 1 2 3 3 3 3 Nucleoporin FG repeat region zf-RING_5 PF14634.6 EWC45449.1 - 1.1e-05 25.2 6.1 2e-05 24.4 6.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EWC45449.1 - 0.00021 21.5 3.3 0.00039 20.7 3.3 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EWC45449.1 - 0.0032 17.3 4.9 0.0071 16.2 4.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EWC45449.1 - 0.0082 16.0 6.8 0.015 15.1 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) YabA PF06156.13 EWC45449.1 - 0.011 16.4 4.5 0.031 14.9 4.5 1.7 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 EWC45449.1 - 0.012 16.1 7.3 0.025 15.0 7.3 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF948 PF06103.11 EWC45449.1 - 0.012 15.8 1.7 0.023 14.9 1.7 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) zf-RING_UBOX PF13445.6 EWC45449.1 - 0.013 15.5 1.5 0.03 14.4 1.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DUF4698 PF15769.5 EWC45449.1 - 0.033 13.3 0.8 0.044 12.9 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) JAKMIP_CC3 PF16034.5 EWC45449.1 - 0.044 13.7 3.9 0.077 12.9 3.9 1.3 1 0 0 1 1 1 0 JAKMIP CC3 domain zf-C3HC4_2 PF13923.6 EWC45449.1 - 0.062 13.1 6.1 0.43 10.4 6.2 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) KASH_CCD PF14662.6 EWC45449.1 - 0.065 13.1 6.7 0.081 12.7 6.0 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH zf-C3HC4_3 PF13920.6 EWC45449.1 - 0.067 13.1 3.6 0.16 11.8 3.6 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HAP1_N PF04849.13 EWC45449.1 - 0.082 12.1 5.1 0.13 11.5 5.1 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Mito_carr PF00153.27 EWC45449.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial carrier protein DUF4407 PF14362.6 EWC45449.1 - 0.21 10.9 3.5 0.32 10.3 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 EWC45449.1 - 0.33 11.5 5.2 0.63 10.6 5.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region SlyX PF04102.12 EWC45449.1 - 0.41 11.3 4.6 2.2 9.0 2.9 2.7 1 1 2 3 3 3 0 SlyX zf-C3HC4_4 PF15227.6 EWC45449.1 - 0.43 10.8 5.6 0.89 9.8 5.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Syntaxin-6_N PF09177.11 EWC45449.1 - 0.59 10.7 3.5 1 10.0 2.5 1.9 2 1 0 2 2 1 0 Syntaxin 6, N-terminal ADIP PF11559.8 EWC45449.1 - 0.75 9.9 12.5 0.13 12.3 8.4 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ABC_tran_CTD PF16326.5 EWC45449.1 - 0.84 9.9 3.8 3 8.1 3.8 1.9 1 1 0 1 1 1 0 ABC transporter C-terminal domain BST2 PF16716.5 EWC45449.1 - 1.2 9.8 9.6 0.66 10.6 6.5 2.2 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 CASP_C PF08172.12 EWC45449.1 - 1.8 7.9 8.9 0.62 9.4 5.1 2.1 2 1 1 3 3 3 0 CASP C terminal zf-rbx1 PF12678.7 EWC45449.1 - 2.5 8.5 5.7 5.7 7.3 5.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain DivIC PF04977.15 EWC45449.1 - 7.3 6.4 10.5 31 4.4 8.7 2.7 1 1 1 2 2 2 0 Septum formation initiator DUF4387 PF14330.6 EWC45450.1 - 1.6e-38 131.3 0.0 2.9e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4387) AtuA PF07287.11 EWC45450.1 - 3.7e-18 65.4 0.0 7.9e-17 61.0 0.0 2.1 1 1 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Aldolase_II PF00596.21 EWC45451.1 - 2.1e-46 158.2 0.2 2.6e-46 157.9 0.2 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain COesterase PF00135.28 EWC45452.1 - 1.2e-64 219.0 0.0 3.1e-64 217.7 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EWC45452.1 - 6.8e-11 42.4 0.0 1.4e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EWC45452.1 - 0.0022 17.5 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family SesA PF17107.5 EWC45455.1 - 0.036 14.3 2.3 0.094 12.9 2.0 1.9 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases NOG1_N PF17835.1 EWC45455.1 - 0.054 13.5 2.8 1.9 8.4 0.1 2.3 1 1 0 2 2 2 0 NOG1 N-terminal helical domain Baculo_F PF12259.8 EWC45455.1 - 0.13 10.7 0.8 0.18 10.3 0.8 1.1 1 0 0 1 1 1 0 Baculovirus F protein NACHT_N PF17100.5 EWC45455.1 - 7.4 6.4 7.0 4.1 7.2 3.3 2.0 1 1 2 3 3 3 0 N-terminal domain of NWD NACHT-NTPase WD40 PF00400.32 EWC45458.1 - 3.3e-09 37.2 3.4 0.62 11.0 0.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EWC45458.1 - 0.0076 15.2 0.1 0.045 12.7 0.0 2.1 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein F-box-like PF12937.7 EWC45459.1 - 1.2e-05 25.1 0.1 3e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like PRP1_N PF06424.12 EWC45459.1 - 2.6 8.4 6.3 0.31 11.4 0.2 2.1 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal MFS_1 PF07690.16 EWC45460.1 - 7e-22 77.8 46.8 5.5e-21 74.9 46.8 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily SpoVS PF04232.12 EWC45460.1 - 0.11 12.2 3.8 1.7 8.5 0.1 2.5 2 0 0 2 2 2 0 Stage V sporulation protein S (SpoVS) cEGF PF12662.7 EWC45461.1 - 0.42 10.6 2.5 0.96 9.4 0.3 2.5 3 0 0 3 3 3 0 Complement Clr-like EGF-like Egh16-like PF11327.8 EWC45462.1 - 6.7e-58 196.1 0.0 2.8e-57 194.1 0.0 1.9 1 1 0 1 1 1 1 Egh16-like virulence factor Pentapeptide_2 PF01469.18 EWC45462.1 - 0.015 15.2 45.1 0.015 15.2 45.1 4.0 2 1 1 3 3 3 0 Pentapeptide repeats (8 copies) An_peroxidase PF03098.15 EWC45463.1 - 1.2e-36 126.4 0.0 1.9e-27 96.1 0.0 3.2 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EWC45463.1 - 3.1e-05 22.9 0.1 0.00024 20.0 0.0 2.0 2 0 0 2 2 2 1 Cytochrome P450 An_peroxidase PF03098.15 EWC45464.1 - 3.5e-37 128.2 0.1 4.4e-14 51.9 0.2 4.0 2 1 1 3 3 3 3 Animal haem peroxidase p450 PF00067.22 EWC45464.1 - 6.3e-09 35.1 0.0 5.1e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 Cytochrome P450 Peroxidase_2 PF01328.17 EWC45465.1 - 2.7e-44 151.9 0.0 3.9e-44 151.4 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 Ribosomal_S4Pg PF11993.8 EWC45465.1 - 0.12 12.4 0.1 2.9 7.9 0.0 2.1 1 1 1 2 2 2 0 Ribosomal S4P (gammaproteobacterial) Alveol-reg_P311 PF11092.8 EWC45465.1 - 0.13 12.4 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) DDHD PF02862.17 EWC45466.1 - 2.3e-24 86.8 0.0 6.9e-15 55.8 0.0 2.7 1 1 1 2 2 2 2 DDHD domain OppC_N PF12911.7 EWC45468.1 - 0.016 15.2 1.6 1.1 9.2 0.0 2.9 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Na_Ca_ex PF01699.24 EWC45468.1 - 0.053 13.5 2.7 0.31 11.0 2.7 2.0 1 1 0 1 1 1 0 Sodium/calcium exchanger protein SET PF00856.28 EWC45469.1 - 1.4e-08 35.3 0.2 1.3e-07 32.1 0.0 2.5 2 1 0 2 2 2 1 SET domain TPR_2 PF07719.17 EWC45469.1 - 0.0081 16.2 5.9 8 6.8 0.3 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC45469.1 - 0.027 14.7 0.4 3.5 7.9 0.1 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EWC45469.1 - 0.27 11.6 1.9 83 3.8 0.2 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EWC45469.1 - 0.74 10.1 6.4 2.1 8.7 0.4 4.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EWC45469.1 - 1.2 8.9 9.6 0.09 12.5 2.8 2.7 2 1 0 2 2 2 0 TPR repeat zf-C2H2_4 PF13894.6 EWC45470.1 - 0.0074 17.0 5.5 1.8 9.6 0.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EWC45470.1 - 0.023 15.1 11.6 0.3 11.6 3.3 3.2 2 1 0 2 2 2 0 Zinc finger, C2H2 type IBR PF01485.21 EWC45470.1 - 0.031 14.5 2.3 0.63 10.3 0.3 2.2 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zinc_ribbon_4 PF13717.6 EWC45470.1 - 0.076 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Lar_restr_allev PF14354.6 EWC45470.1 - 0.077 13.4 0.3 2.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Restriction alleviation protein Lar PQ-loop PF04193.14 EWC45471.1 - 0.027 14.2 11.0 0.094 12.5 0.1 4.0 4 0 0 4 4 4 0 PQ loop repeat Polyketide_cyc2 PF10604.9 EWC45472.1 - 0.00043 20.6 0.4 0.00071 19.9 0.4 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport zf-C2H2_4 PF13894.6 EWC45474.1 - 7.8e-07 29.4 4.2 0.036 14.9 0.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EWC45474.1 - 3.9e-05 23.9 9.9 0.0053 17.1 0.9 3.7 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EWC45474.1 - 0.0031 18.2 0.1 0.019 15.7 0.1 2.1 2 0 0 2 2 2 1 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 EWC45474.1 - 0.0033 17.4 7.7 0.45 10.6 0.5 3.6 3 0 0 3 3 3 2 BED zinc finger zf-Di19 PF05605.12 EWC45474.1 - 0.01 16.1 1.7 0.2 12.0 0.6 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 EWC45474.1 - 0.031 14.1 7.1 0.95 9.3 1.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 EWC45474.1 - 0.062 13.8 9.9 6.5 7.4 0.4 3.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 EWC45474.1 - 0.068 13.2 6.6 1.1 9.3 0.4 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf_Hakai PF18408.1 EWC45474.1 - 0.23 11.2 2.1 0.26 11.0 0.1 2.1 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-met PF12874.7 EWC45474.1 - 0.62 10.5 4.7 0.26 11.7 1.7 2.1 2 0 0 2 2 1 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EWC45474.1 - 2.7 8.4 5.1 3.6 8.0 1.5 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) adh_short PF00106.25 EWC45475.1 - 2.1e-17 63.2 0.0 6.2e-14 51.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC45475.1 - 1.2e-08 34.8 0.1 4.7e-08 32.9 0.1 1.8 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC45475.1 - 5.8e-08 32.9 0.0 8.8e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Citrate_synt PF00285.21 EWC45476.1 - 2.5e-19 69.6 0.0 3.8e-16 59.1 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 EWC45476.1 - 1.8e-17 63.6 0.1 3.5e-17 62.6 0.1 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 EWC45476.1 - 8e-16 58.5 0.0 2.1e-15 57.2 0.0 1.8 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 EWC45476.1 - 9.1e-07 28.8 0.0 1.3e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain NifZ PF04319.13 EWC45476.1 - 0.15 11.8 0.1 2.5 7.9 0.2 2.6 2 0 0 2 2 2 0 NifZ domain Citrate_bind PF16114.5 EWC45477.1 - 2.2e-84 281.4 0.1 3.2e-84 280.9 0.1 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EWC45477.1 - 2.2e-08 33.9 0.0 3.4e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain TPR_2 PF07719.17 EWC45478.1 - 0.0021 18.1 0.1 2 8.7 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC45478.1 - 0.0052 16.6 0.7 1.9 8.5 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EWC45478.1 - 0.016 15.5 0.4 0.075 13.3 0.3 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat Spore_III_AF PF09581.10 EWC45478.1 - 0.73 9.8 2.7 1.5 8.8 2.7 1.5 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) HAD_2 PF13419.6 EWC45479.1 - 2e-16 60.6 0.0 1.2e-15 58.0 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EWC45479.1 - 1.3e-07 32.1 0.0 1.5e-06 28.7 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EWC45479.1 - 0.00061 19.8 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Peptidase_C1_2 PF03051.15 EWC45480.1 - 6.3e-146 486.6 0.1 7.8e-146 486.3 0.1 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EWC45480.1 - 0.0012 18.9 2.6 0.0035 17.5 2.5 1.7 1 1 0 1 1 1 1 Papain family cysteine protease PQ-loop PF04193.14 EWC45483.1 - 2.7e-21 75.1 14.8 2e-12 46.7 1.0 2.9 3 0 0 3 3 3 2 PQ loop repeat DUF4191 PF13829.6 EWC45483.1 - 0.35 10.2 1.9 0.72 9.2 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) Rib_5-P_isom_A PF06026.14 EWC45484.1 - 1.1e-48 165.1 0.0 1.5e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EWC45484.1 - 0.1 12.5 0.0 8.4 6.3 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain TFA2_Winged_2 PF18121.1 EWC45484.1 - 0.17 11.6 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 ThiF PF00899.21 EWC45485.1 - 7.9e-16 58.1 0.0 1.5e-15 57.2 0.0 1.5 1 1 0 1 1 1 1 ThiF family T3SS_needle_F PF09392.10 EWC45485.1 - 0.14 12.3 0.2 0.56 10.4 0.0 2.0 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF XAP5 PF04921.14 EWC45487.1 - 9.4e-81 271.3 0.0 1.4e-80 270.7 0.0 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator DUF1921 PF09081.10 EWC45487.1 - 0.21 11.8 0.6 0.4 11.0 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1921) Radical_SAM PF04055.21 EWC45488.1 - 1.7e-23 83.8 0.0 1.1e-22 81.2 0.1 2.3 2 1 0 2 2 2 1 Radical SAM superfamily Wyosine_form PF08608.12 EWC45488.1 - 3e-23 81.9 0.0 6.7e-23 80.8 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.25 EWC45488.1 - 1.5e-13 51.2 0.0 2.3e-08 34.4 0.0 3.1 3 0 0 3 3 3 2 Flavodoxin Flavodoxin_5 PF12724.7 EWC45488.1 - 0.11 12.7 0.0 0.37 11.0 0.0 1.8 2 0 0 2 2 2 0 Flavodoxin domain F-box-like PF12937.7 EWC45490.1 - 2.5e-07 30.5 0.0 5.1e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC45490.1 - 3.4e-07 30.0 0.0 9.6e-07 28.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EWC45490.1 - 0.0061 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 F-box SNF2_N PF00176.23 EWC45491.1 - 5.3e-54 183.2 0.2 1e-53 182.3 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC45491.1 - 9.3e-16 58.2 0.0 4.2e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EWC45491.1 - 9.6e-08 31.5 0.0 3.6e-07 29.6 0.0 2.0 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EWC45491.1 - 4.8e-06 26.7 0.0 3e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PHD PF00628.29 EWC45491.1 - 0.086 12.8 28.2 0.023 14.6 16.5 3.0 2 1 1 3 3 3 0 PHD-finger Toprim_3 PF13362.6 EWC45491.1 - 0.31 11.4 1.4 1.3 9.4 0.4 2.4 2 0 0 2 2 2 0 Toprim domain Zf_RING PF16744.5 EWC45491.1 - 0.53 10.4 20.0 13 5.9 8.8 2.6 1 1 1 2 2 2 0 KIAA1045 RING finger adh_short PF00106.25 EWC45492.1 - 4.2e-20 72.0 0.0 6.9e-14 51.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC45492.1 - 2.8e-14 53.2 0.0 5.5e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC45492.1 - 0.00025 21.0 0.0 0.00042 20.3 0.0 1.3 1 1 0 1 1 1 1 KR domain UPF0261 PF06792.11 EWC45494.1 - 1.9e-139 465.1 0.0 2.2e-139 464.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) UDPGT PF00201.18 EWC45495.1 - 2e-13 50.0 0.0 2.6e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EWC45495.1 - 0.0003 20.8 0.0 0.00047 20.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_2 PF13477.6 EWC45495.1 - 0.089 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like Spo7_2_N PF15407.6 EWC45495.1 - 0.12 12.1 0.0 1 9.1 0.0 2.2 2 0 0 2 2 2 0 Sporulation protein family 7 NiFe_hyd_SSU_C PF14720.6 EWC45496.1 - 0.031 14.7 3.3 0.056 13.8 3.3 1.4 1 0 0 1 1 1 0 NiFe/NiFeSe hydrogenase small subunit C-terminal Acyl_transf_3 PF01757.22 EWC45499.1 - 4.4e-28 98.3 26.2 6.2e-28 97.8 26.2 1.2 1 0 0 1 1 1 1 Acyltransferase family Tim44 PF04280.15 EWC45500.1 - 0.027 14.6 0.1 0.38 10.9 0.0 2.2 2 0 0 2 2 2 0 Tim44-like domain LppX_LprAFG PF07161.13 EWC45500.1 - 0.11 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 LppX_LprAFG lipoprotein HNH PF01844.23 EWC45500.1 - 0.25 11.5 1.0 1.8 8.8 0.1 2.2 1 1 1 2 2 2 0 HNH endonuclease DUF676 PF05057.14 EWC45501.1 - 0.0018 17.8 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) AAA_16 PF13191.6 EWC45501.1 - 0.0021 18.4 0.0 0.0047 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Abhydrolase_6 PF12697.7 EWC45501.1 - 0.006 17.2 0.0 0.016 15.8 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EWC45501.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein AAA_22 PF13401.6 EWC45501.1 - 0.062 13.6 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain KcnmB2_inactiv PF09303.10 EWC45501.1 - 0.11 12.4 0.0 0.39 10.6 0.0 2.1 1 0 0 1 1 1 0 KCNMB2, ball and chain domain ATPase_2 PF01637.18 EWC45501.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PGM_PMM_I PF02878.16 EWC45505.1 - 1.9e-33 115.1 0.1 3.9e-32 110.8 0.0 2.4 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EWC45505.1 - 2.5e-24 85.9 0.1 7.1e-24 84.4 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EWC45505.1 - 1.2e-12 48.0 0.7 2.9e-12 46.8 0.1 2.0 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EWC45505.1 - 5.5e-09 36.1 0.1 2.4e-08 34.0 0.1 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ECH_1 PF00378.20 EWC45506.1 - 2.6e-48 164.5 0.0 3.2e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EWC45506.1 - 1.1e-21 77.7 0.1 1.4e-21 77.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase zf-C2H2_4 PF13894.6 EWC45507.1 - 1.2e-05 25.7 22.7 0.063 14.1 0.2 6.0 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EWC45507.1 - 0.00097 19.4 8.1 0.37 11.1 0.1 4.1 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met2 PF12907.7 EWC45507.1 - 0.0082 16.3 3.8 0.81 9.9 0.1 2.9 2 0 0 2 2 2 2 Zinc-binding zf-met PF12874.7 EWC45507.1 - 0.073 13.5 0.1 0.073 13.5 0.1 5.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EWC45507.1 - 3 8.2 16.0 0.69 10.3 0.8 3.7 4 1 1 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EWC45507.1 - 7.1 7.0 17.1 1.9 8.8 0.1 4.0 4 1 1 5 5 5 0 C2H2 type zinc-finger (2 copies) Glyco_transf_90 PF05686.12 EWC45508.1 - 2.4e-16 59.6 0.3 1.7e-13 50.2 0.1 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 90 RrnaAD PF00398.20 EWC45509.1 - 4.1e-15 55.6 0.0 8.1e-15 54.6 0.0 1.4 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase LCM PF04072.14 EWC45510.1 - 1.6e-30 106.5 0.0 2.9e-30 105.6 0.0 1.5 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase ADPRTs_Tse2 PF18648.1 EWC45510.1 - 0.13 12.3 0.0 0.43 10.6 0.0 1.9 2 0 0 2 2 2 0 Tse2 ADP-ribosyltransferase toxins DUF2013 PF09431.10 EWC45511.1 - 2.5e-51 173.5 4.2 9e-51 171.7 1.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2013) MutS_V PF00488.21 EWC45512.1 - 8.1e-82 273.8 0.2 2.5e-81 272.2 0.4 1.7 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EWC45512.1 - 2.7e-36 125.6 0.6 6.8e-36 124.3 0.6 1.7 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 EWC45512.1 - 7.8e-22 78.0 0.1 7.8e-22 78.0 0.1 2.4 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 EWC45512.1 - 5e-19 68.4 0.9 5e-19 68.4 0.9 2.2 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.20 EWC45512.1 - 9.8e-19 67.7 0.0 5.8e-18 65.2 0.0 2.2 2 0 0 2 2 2 1 MutS domain I eIF2A PF08662.11 EWC45513.1 - 2.2e-78 262.6 0.6 1.4e-76 256.7 0.0 2.8 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EWC45513.1 - 2.2e-05 24.2 0.5 0.22 11.5 0.0 4.5 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat WD40 PF00400.32 EWC45513.1 - 0.019 15.8 1.0 5.7 8.0 0.1 4.5 4 1 1 5 5 5 0 WD domain, G-beta repeat Proteasome_A_N PF10584.9 EWC45513.1 - 0.043 13.5 0.5 17 5.2 0.0 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature CDV3 PF15359.6 EWC45513.1 - 6 7.4 13.2 0.29 11.6 0.5 3.4 3 0 0 3 3 3 0 Carnitine deficiency-associated protein 3 JAB PF01398.21 EWC45514.1 - 3.4e-16 59.3 0.0 8.7e-16 58.0 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 EWC45514.1 - 1.2e-10 41.6 0.3 2.4e-10 40.6 0.3 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 EWC45514.1 - 8.2e-05 22.4 0.0 0.00027 20.7 0.0 1.8 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Prenylcys_lyase PF07156.14 EWC45515.1 - 1.4e-82 277.7 0.0 1.6e-82 277.5 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 EWC45515.1 - 4.6e-11 42.8 0.0 1.2e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EWC45515.1 - 2.8e-09 37.0 0.0 2.8e-06 27.1 0.0 2.4 2 1 1 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EWC45515.1 - 2.5e-08 33.7 0.0 3.7e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EWC45515.1 - 1.7e-05 24.2 0.1 0.0054 16.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC45515.1 - 0.00089 19.3 0.0 0.02 14.9 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EWC45515.1 - 0.0012 18.1 0.2 0.3 10.3 0.0 2.2 2 0 0 2 2 2 2 Thi4 family K_oxygenase PF13434.6 EWC45515.1 - 0.026 13.7 0.0 6.4 5.8 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EWC45515.1 - 0.071 13.7 0.2 0.57 10.8 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Dynein_IC2 PF11540.8 EWC45515.1 - 0.13 12.2 0.6 0.31 11.0 0.6 1.6 1 0 0 1 1 1 0 Cytoplasmic dynein 1 intermediate chain 2 RTC4 PF14474.6 EWC45516.1 - 1.3e-24 86.6 0.0 2.6e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain Peroxin-13_N PF04088.13 EWC45517.1 - 1e-51 175.1 0.1 1.6e-51 174.4 0.1 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 EWC45517.1 - 3.8e-08 32.8 0.0 6.5e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EWC45517.1 - 1.1e-06 28.2 0.0 2.5e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Cmc1 PF08583.10 EWC45518.1 - 1e-13 51.1 3.2 1.2e-13 50.8 3.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Ribonuclease_P PF00825.18 EWC45518.1 - 0.036 14.1 0.2 0.041 14.0 0.2 1.1 1 0 0 1 1 1 0 Ribonuclease P TetR_C_24 PF17932.1 EWC45518.1 - 0.054 13.7 0.1 0.064 13.5 0.1 1.1 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Prefoldin_2 PF01920.20 EWC45519.1 - 4e-25 87.8 0.6 4.6e-25 87.6 0.6 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF2205 PF10224.9 EWC45519.1 - 0.00028 20.8 1.6 0.1 12.6 0.7 2.1 2 0 0 2 2 2 2 Short coiled-coil protein MAGSP PF03082.14 EWC45519.1 - 0.0033 17.1 0.3 0.0047 16.6 0.3 1.2 1 0 0 1 1 1 1 Male accessory gland secretory protein SLATT_1 PF18181.1 EWC45519.1 - 0.021 14.8 1.6 0.033 14.1 1.2 1.5 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Syntaxin-6_N PF09177.11 EWC45519.1 - 0.036 14.6 0.9 0.059 13.9 0.9 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal NAD_binding_4 PF07993.12 EWC45519.1 - 0.084 12.0 0.1 0.1 11.7 0.1 1.1 1 0 0 1 1 1 0 Male sterility protein CLZ PF16526.5 EWC45519.1 - 0.09 13.2 1.5 16 5.9 0.0 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels bZIP_Maf PF03131.17 EWC45519.1 - 0.2 12.2 3.5 14 6.3 2.4 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor CBFD_NFYB_HMF PF00808.23 EWC45520.1 - 3.1e-30 104.2 1.0 4.3e-30 103.8 1.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EWC45520.1 - 2e-06 28.2 0.1 2.7e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 EWC45520.1 - 0.00032 20.7 0.0 0.00052 20.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 EWC45520.1 - 0.00053 20.0 0.1 0.00078 19.4 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 EWC45520.1 - 0.0013 18.8 0.0 0.0017 18.5 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 EWC45520.1 - 0.01 16.3 0.1 0.038 14.5 0.1 1.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A DUF3716 PF12511.8 EWC45521.1 - 0.36 10.9 5.3 0.2 11.7 2.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) Peptidase_C14 PF00656.22 EWC45522.1 - 6.5e-61 206.4 0.0 8e-61 206.1 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 EWC45522.1 - 0.11 12.4 0.0 0.39 10.6 0.0 2.0 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain FA_desaturase PF00487.24 EWC45523.1 - 8.8e-29 101.1 19.1 1.3e-28 100.6 19.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EWC45523.1 - 7.7e-09 35.6 0.0 1.7e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain AtpR PF12966.7 EWC45523.1 - 0.033 14.6 0.2 0.077 13.4 0.2 1.6 1 0 0 1 1 1 0 N-ATPase, AtpR subunit Adeno_E3B PF03376.14 EWC45524.1 - 0.074 13.3 0.6 0.074 13.3 0.6 2.2 2 0 0 2 2 2 0 Adenovirus E3B protein TPR_1 PF00515.28 EWC45525.1 - 1.5e-11 43.6 0.5 4.2e-07 29.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EWC45525.1 - 2e-09 36.8 0.6 6.8e-05 22.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EWC45525.1 - 8.2e-07 28.8 0.1 0.00016 21.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EWC45525.1 - 7.3e-05 22.4 0.1 0.00039 20.0 0.1 2.4 1 1 0 1 1 1 1 TPR repeat TPR_12 PF13424.6 EWC45525.1 - 0.00028 21.1 0.6 0.0047 17.2 0.2 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EWC45525.1 - 0.00043 20.1 0.1 0.002 18.0 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EWC45525.1 - 0.00077 19.9 0.2 0.56 11.0 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EWC45525.1 - 0.0041 17.7 0.1 0.12 13.0 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EWC45525.1 - 0.0071 16.7 0.0 3.7 8.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat PB1 PF00564.24 EWC45525.1 - 0.0071 16.2 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 PB1 domain TPR_14 PF13428.6 EWC45525.1 - 0.012 16.4 0.0 0.06 14.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.9 EWC45525.1 - 0.073 12.8 0.2 9.1 6.0 0.0 2.3 1 1 0 2 2 2 0 26S proteasome subunit RPN7 Paf67 PF10255.9 EWC45525.1 - 0.13 11.3 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 DUF3808 PF10300.9 EWC45525.1 - 0.18 10.5 0.0 0.32 9.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Aconitase PF00330.20 EWC45527.1 - 1.1e-81 275.3 0.8 1.3e-80 271.7 0.8 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EWC45527.1 - 8.1e-23 81.2 0.0 1.5e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Lipoxygenase PF00305.19 EWC45528.1 - 1.4e-30 106.4 0.0 2e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Lipoxygenase PDCD2_C PF04194.13 EWC45529.1 - 3.6e-39 134.6 0.0 6.2e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain KAR9 PF08580.10 EWC45529.1 - 3.4 6.1 9.2 4.3 5.8 9.2 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Glyco_transf_22 PF03901.17 EWC45530.1 - 7.4e-37 127.6 9.4 9.6e-37 127.2 9.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CCB1 PF12046.8 EWC45530.1 - 1.1 8.6 4.4 0.24 10.7 0.6 1.8 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B Yos1 PF08571.10 EWC45531.1 - 9.4e-09 35.4 0.0 1.1e-08 35.2 0.0 1.0 1 0 0 1 1 1 1 Yos1-like CBS PF00571.28 EWC45532.1 - 2.7e-05 24.5 0.0 0.32 11.5 0.0 3.0 1 1 1 2 2 2 2 CBS domain GARS_N PF02844.15 EWC45532.1 - 0.062 14.1 0.0 0.31 11.9 0.0 1.9 1 1 1 2 2 2 0 Phosphoribosylglycinamide synthetase, N domain Coatomer_WDAD PF04053.14 EWC45532.1 - 0.13 11.3 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Coatomer WD associated region Aminotran_1_2 PF00155.21 EWC45534.1 - 4.3e-15 55.8 0.0 5.8e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EWC45534.1 - 0.094 11.5 0.0 2 7.1 0.0 2.1 2 0 0 2 2 2 0 Alanine-glyoxylate amino-transferase Ribonuc_P_40 PF08584.11 EWC45535.1 - 0.055 12.8 0.1 0.086 12.1 0.1 1.2 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit Epimerase PF01370.21 EWC45536.1 - 5e-20 72.0 0.0 7.1e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EWC45536.1 - 5.4e-09 35.5 0.0 7.9e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EWC45536.1 - 1.3e-07 31.4 0.0 1.9e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EWC45536.1 - 7.6e-06 25.1 0.0 1.4e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF2417 PF10329.9 EWC45538.1 - 9.9e-76 254.3 0.4 1.3e-75 253.9 0.4 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) DUF5134 PF17197.4 EWC45538.1 - 0.00022 21.2 0.1 0.25 11.3 0.1 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF5134) Hydrolase_4 PF12146.8 EWC45538.1 - 0.011 15.0 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 GWT1 PF06423.12 EWC45538.1 - 0.032 14.4 1.1 6.5 6.9 0.3 2.4 2 0 0 2 2 2 0 GWT1 Abhydrolase_1 PF00561.20 EWC45538.1 - 0.14 11.7 0.1 0.24 11.0 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Shisa PF13908.6 EWC45538.1 - 0.28 11.4 0.0 0.61 10.3 0.0 1.6 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF3357 PF11837.8 EWC45538.1 - 0.88 10.1 3.2 1.6 9.2 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) Colicin_V PF02674.16 EWC45538.1 - 1.9 8.5 12.3 0.069 13.1 3.2 2.6 3 0 0 3 3 3 0 Colicin V production protein DUF2269 PF10027.9 EWC45538.1 - 2 8.5 16.5 0.024 14.7 3.8 2.9 3 0 0 3 3 3 0 Predicted integral membrane protein (DUF2269) ABC2_membrane_2 PF12679.7 EWC45538.1 - 2.7 7.2 8.6 5.3 6.2 8.6 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein Choline_transpo PF04515.12 EWC45538.1 - 3.3 6.8 11.0 4.2 6.5 6.2 2.2 2 0 0 2 2 2 0 Plasma-membrane choline transporter UCH PF00443.29 EWC45540.1 - 2.9e-60 203.9 0.0 5.5e-60 203.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EWC45540.1 - 3.9e-24 85.8 1.5 1.4e-17 64.3 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EWC45540.1 - 0.0087 15.6 1.9 0.27 10.7 0.5 3.1 3 0 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase Presenilin PF01080.17 EWC45540.1 - 0.57 8.9 6.3 1.2 7.9 6.3 1.5 1 0 0 1 1 1 0 Presenilin Sec20 PF03908.13 EWC45541.1 - 7.5e-15 54.6 0.0 1.9e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 Sec20 Cep57_MT_bd PF06657.13 EWC45541.1 - 0.00014 22.2 0.6 0.0049 17.3 0.1 2.7 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 Elong-fact-P_C PF09285.11 EWC45541.1 - 0.11 12.3 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Elongation factor P, C-terminal 2TM PF13239.6 EWC45541.1 - 4.9 7.5 5.5 8.2 6.8 5.5 1.3 1 0 0 1 1 1 0 2TM domain Pyrophosphatase PF00719.19 EWC45542.1 - 1.2e-57 194.2 0.1 1.5e-57 193.9 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase ABC_membrane PF00664.23 EWC45544.1 - 4.7e-41 141.2 13.4 6.2e-41 140.8 13.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EWC45544.1 - 9.2e-34 116.9 0.0 2.4e-33 115.6 0.0 1.7 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 EWC45544.1 - 2.5e-05 23.8 0.2 0.0013 18.2 0.2 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 EWC45544.1 - 0.00057 20.3 0.0 0.018 15.5 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC45544.1 - 0.0012 19.3 0.0 0.0027 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EWC45544.1 - 0.0073 16.1 0.0 0.062 13.1 0.0 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EWC45544.1 - 0.016 15.1 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EWC45544.1 - 0.025 14.9 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EWC45544.1 - 0.038 13.7 0.1 0.12 12.1 0.1 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EWC45544.1 - 0.046 13.3 0.0 0.15 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EWC45544.1 - 0.053 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EWC45544.1 - 0.057 13.5 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase cwf18 PF08315.12 EWC45544.1 - 0.059 14.0 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor Herpes_UL74 PF07982.12 EWC45544.1 - 0.08 11.9 2.6 0.14 11.1 2.6 1.4 1 0 0 1 1 1 0 Herpes UL74 glycoproteins AAA_14 PF13173.6 EWC45544.1 - 0.082 12.9 0.0 0.66 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EWC45544.1 - 0.095 13.2 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EWC45544.1 - 0.095 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 EWC45544.1 - 0.11 12.2 0.1 0.4 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 EWC45544.1 - 0.11 11.4 0.0 0.48 9.3 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain SbcCD_C PF13558.6 EWC45544.1 - 0.12 12.6 0.7 2.8 8.3 0.7 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EWC45544.1 - 0.23 11.1 0.0 0.46 10.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain DIOX_N PF14226.6 EWC45545.1 - 7.6e-23 81.5 0.2 2.5e-22 79.9 0.2 1.8 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EWC45545.1 - 9.2e-13 48.5 0.0 1.8e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NAD_binding_10 PF13460.6 EWC45546.1 - 3e-08 33.8 0.0 6.4e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EWC45546.1 - 5.1e-08 32.7 0.2 2.6e-07 30.4 0.1 2.2 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EWC45546.1 - 2.5e-06 26.7 0.0 1.8e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EWC45546.1 - 0.00013 21.6 0.1 0.00032 20.3 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 EWC45546.1 - 0.0027 16.9 0.1 0.022 13.9 0.1 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EWC45546.1 - 0.0099 15.3 0.5 0.024 14.1 0.1 1.8 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase PCI PF01399.27 EWC45548.1 - 4.8e-09 36.7 0.0 1.1e-08 35.5 0.0 1.6 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EWC45548.1 - 9.5e-06 25.1 1.4 2.1e-05 24.0 1.4 1.6 1 0 0 1 1 1 1 Rpn9 C-terminal helix TMCCDC2 PF15844.5 EWC45548.1 - 0.072 13.0 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Transmembrane and coiled-coil domain-containing protein 2 DnaJ PF00226.31 EWC45549.1 - 3.4e-07 30.3 0.1 8e-07 29.1 0.1 1.7 1 1 0 1 1 1 1 DnaJ domain SPA PF08616.10 EWC45550.1 - 0.00065 19.6 0.1 0.0015 18.5 0.1 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EWC45550.1 - 0.0023 16.7 0.1 0.019 13.6 0.0 2.0 2 0 0 2 2 2 1 Transport protein Avl9 Vac14_Fig4_bd PF11916.8 EWC45551.1 - 4.5e-78 261.0 6.5 9.4e-78 260.0 6.5 1.6 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EWC45551.1 - 4.9e-44 148.9 0.1 3.1e-41 139.9 0.0 3.6 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EWC45551.1 - 9.6e-07 28.5 0.8 0.0017 18.4 0.0 5.3 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EWC45551.1 - 2.7e-05 24.3 3.6 0.018 15.1 0.3 3.5 3 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EWC45551.1 - 0.00091 19.7 1.2 0.062 13.8 0.0 4.0 4 0 0 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 EWC45551.1 - 0.01 16.2 4.5 0.92 9.9 0.0 4.0 5 0 0 5 5 5 0 HEAT repeats Arm PF00514.23 EWC45551.1 - 0.059 13.4 0.1 30 4.8 0.0 4.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Ribo_biogen_C PF04034.13 EWC45552.1 - 1e-52 177.2 0.0 3.1e-52 175.6 0.0 1.9 2 0 0 2 2 2 1 Ribosome biogenesis protein, C-terminal GTP_EFTU PF00009.27 EWC45552.1 - 6.1e-33 114.0 1.8 1.5e-31 109.5 1.8 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EWC45552.1 - 4.3e-23 81.4 0.2 1.1e-22 80.2 0.2 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 RLI PF04068.15 EWC45552.1 - 1.5e-13 50.3 1.3 1.5e-13 50.3 1.3 2.2 3 0 0 3 3 3 1 Possible Fer4-like domain in RNase L inhibitor, RLI MMR_HSR1 PF01926.23 EWC45552.1 - 4.8e-09 36.3 0.1 1.3e-08 34.9 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EWC45552.1 - 2.3e-07 31.1 2.5 0.0032 17.8 0.4 2.8 2 0 0 2 2 2 2 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 EWC45552.1 - 9.8e-05 22.3 0.3 0.0026 17.7 0.0 2.4 1 1 1 2 2 2 1 RsgA GTPase Arf PF00025.21 EWC45552.1 - 0.00024 20.6 0.0 0.00048 19.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EWC45552.1 - 0.00032 20.3 0.0 0.00059 19.5 0.0 1.4 1 0 0 1 1 1 1 Ras family IF2_N PF04760.15 EWC45552.1 - 0.00058 19.6 0.0 0.0014 18.4 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region SRPRB PF09439.10 EWC45552.1 - 0.001 18.5 0.0 0.001 18.5 0.0 2.0 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EWC45552.1 - 0.0062 16.8 0.0 0.015 15.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EWC45552.1 - 0.14 12.2 1.0 3.9 7.5 0.0 3.2 2 1 1 3 3 3 0 Dynamin family S4_2 PF13275.6 EWC45552.1 - 1.1 9.1 3.9 0.75 9.7 0.6 2.3 2 0 0 2 2 2 0 S4 domain AAA_23 PF13476.6 EWC45552.1 - 6.1 7.3 12.6 27 5.2 0.0 3.5 3 0 0 3 3 3 0 AAA domain VHS PF00790.19 EWC45553.1 - 2.8e-44 150.4 0.0 1.4e-43 148.1 0.0 2.0 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EWC45553.1 - 3.8e-18 65.6 1.9 3.8e-18 65.6 1.9 2.4 2 0 0 2 2 2 1 GAT domain Alpha_adaptinC2 PF02883.20 EWC45553.1 - 6.2e-14 52.2 0.0 1.6e-13 50.9 0.0 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 EWC45553.1 - 1e-06 28.2 0.0 3.8e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 GGA N-GAT domain ZnuA PF01297.17 EWC45553.1 - 0.093 12.1 2.8 0.17 11.2 2.8 1.4 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic DUF4192 PF13830.6 EWC45553.1 - 2.4 8.2 5.1 10 6.1 5.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4192) Na_H_Exchanger PF00999.21 EWC45554.1 - 1.9e-55 188.3 53.1 1.9e-55 188.3 53.1 1.6 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family Alpha_GJ PF03229.13 EWC45554.1 - 6.2 7.4 12.6 21 5.7 12.6 1.9 1 0 0 1 1 1 0 Alphavirus glycoprotein J Glyco_hydro_18 PF00704.28 EWC45555.1 - 6.8e-76 256.0 0.1 8.3e-76 255.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 AIM24 PF01987.17 EWC45556.1 - 3e-45 154.5 0.1 4.1e-45 154.1 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 UCH PF00443.29 EWC45557.1 - 7.1e-29 101.1 0.1 1.3e-28 100.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EWC45557.1 - 4e-16 59.5 0.8 1.2e-15 57.9 0.8 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EWC45557.1 - 1.5e-07 31.7 13.7 1.5e-07 31.7 13.7 3.3 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein YvrJ PF12841.7 EWC45557.1 - 0.091 12.3 0.2 2.9 7.5 0.1 2.5 2 0 0 2 2 2 0 YvrJ protein family Paired_CXXCH_1 PF09699.10 EWC45557.1 - 1.2 8.9 12.8 3.1 7.6 0.1 3.1 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Y_phosphatase PF00102.27 EWC45558.1 - 1.3e-51 175.5 0.0 1.8e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EWC45558.1 - 0.0041 17.3 0.0 0.0081 16.3 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 EWC45558.1 - 0.0043 16.9 0.0 0.0098 15.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EWC45558.1 - 0.011 15.7 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Bac_DnaA_C PF08299.11 EWC45558.1 - 0.082 12.9 0.3 0.72 9.9 0.1 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix UNC-50 PF05216.13 EWC45559.1 - 1.7e-77 259.9 13.0 1.9e-77 259.8 13.0 1.0 1 0 0 1 1 1 1 UNC-50 family Mrx7 PF10906.8 EWC45560.1 - 2e-16 60.0 0.0 2.3e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 MIOREX complex component 7 L27 PF02828.16 EWC45560.1 - 0.056 13.2 0.0 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 L27 domain L27_2 PF09045.10 EWC45560.1 - 0.077 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 L27_2 DUF624 PF04854.14 EWC45560.1 - 0.086 13.0 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF624 zf-RING_2 PF13639.6 EWC45561.1 - 1.9e-08 34.5 8.1 2.9e-08 33.9 8.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EWC45561.1 - 1.1e-05 25.2 6.0 1.6e-05 24.7 6.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EWC45561.1 - 0.00011 22.4 4.8 0.00018 21.7 4.8 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EWC45561.1 - 0.0006 19.8 2.4 0.0011 18.9 2.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EWC45561.1 - 0.083 12.9 3.7 0.064 13.3 1.9 1.8 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EWC45561.1 - 0.18 11.6 8.1 0.31 10.9 8.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 EWC45561.1 - 0.27 11.4 2.0 0.71 10.0 2.0 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 EWC45561.1 - 0.85 9.5 6.4 1.7 8.5 6.4 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EWC45561.1 - 0.89 9.4 10.9 0.091 12.5 6.4 1.7 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.6 EWC45561.1 - 1.2 9.2 7.2 1.9 8.5 7.2 1.3 1 0 0 1 1 1 0 zinc-RING finger domain SMC_N PF02463.19 EWC45562.1 - 7.8e-78 260.9 0.0 1.9e-77 259.6 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EWC45562.1 - 5.7e-24 84.7 0.0 2e-23 82.9 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EWC45562.1 - 2.3e-12 47.3 2.2 1.8e-05 24.7 0.0 2.9 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EWC45562.1 - 0.00013 21.6 0.0 0.00027 20.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Phage_GP20 PF06810.11 EWC45562.1 - 0.0037 17.1 2.9 0.0037 17.1 2.9 8.5 4 3 5 9 9 9 1 Phage minor structural protein GP20 DivIC PF04977.15 EWC45562.1 - 0.0053 16.5 0.6 0.0053 16.5 0.6 11.2 7 3 6 13 13 13 2 Septum formation initiator ABC_tran PF00005.27 EWC45562.1 - 1.3 9.5 0.0 1.3 9.5 0.0 6.0 3 2 1 4 4 4 0 ABC transporter N6-adenineMlase PF10237.9 EWC45563.1 - 1.2e-33 116.2 0.0 1.6e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Ytp1 PF10355.9 EWC45564.1 - 3.6e-105 351.1 11.7 5.8e-105 350.5 11.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EWC45564.1 - 2e-25 88.6 6.1 2e-25 88.6 6.1 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) CD20 PF04103.15 EWC45564.1 - 0.024 14.7 6.9 2.4 8.3 0.0 3.3 3 1 0 3 3 3 0 CD20-like family Fungal_trans_2 PF11951.8 EWC45565.1 - 1.7e-17 63.3 0.0 1.3e-16 60.5 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF2274 PF10038.9 EWC45565.1 - 0.11 12.9 0.1 0.28 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2274) CDC45 PF02724.14 EWC45565.1 - 3.1 6.0 6.6 6.6 4.9 6.6 1.4 1 0 0 1 1 1 0 CDC45-like protein Spt5_N PF11942.8 EWC45565.1 - 8.5 7.4 13.8 0.27 12.2 6.7 2.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal OTU PF02338.19 EWC45567.1 - 4.3e-07 30.5 0.0 6.9e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease DUF2318 PF10080.9 EWC45567.1 - 0.077 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Glyco_hydro_85 PF03644.13 EWC45568.1 - 4.2e-88 295.6 0.0 5.6e-88 295.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 DASH_Dam1 PF08653.10 EWC45568.1 - 4.8e-24 83.9 1.7 8.9e-24 83.1 1.7 1.5 1 0 0 1 1 1 1 DASH complex subunit Dam1 CEND1 PF15677.5 EWC45568.1 - 0.029 14.9 1.5 0.052 14.1 1.5 1.3 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 FAD_binding_4 PF01565.23 EWC45569.1 - 2.8e-26 91.9 3.2 2.8e-26 91.9 3.2 1.6 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EWC45569.1 - 0.0068 16.5 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like Sec7 PF01369.20 EWC45570.1 - 2.3e-24 86.1 0.0 4.8e-24 85.1 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EWC45570.1 - 1.1e-22 80.7 0.0 3.2e-22 79.1 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EWC45570.1 - 0.0049 17.4 0.0 0.012 16.2 0.0 1.6 1 0 0 1 1 1 1 PH domain DUF3767 PF12597.8 EWC45572.1 - 2.3e-28 98.0 0.8 2.3e-28 98.0 0.8 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) RCDG1 PF15725.5 EWC45572.1 - 0.75 10.3 7.9 1.3 9.5 7.9 1.3 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein DUF1744 PF08490.12 EWC45573.1 - 7.8e-151 502.2 0.2 1.1e-150 501.7 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EWC45573.1 - 8.6e-81 271.7 0.1 8.6e-81 271.7 0.1 2.3 3 0 0 3 3 3 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EWC45573.1 - 9.6e-16 57.5 0.0 1.5e-14 53.6 0.0 2.7 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EWC45573.1 - 2.8e-08 33.7 0.2 9e-08 32.0 0.2 1.8 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EWC45573.1 - 2e-06 27.9 0.0 7.5e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 RNase_H superfamily Cpn60_TCP1 PF00118.24 EWC45574.1 - 3e-152 507.7 8.1 3.4e-152 507.5 8.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GAD PF02938.14 EWC45574.1 - 0.059 13.6 0.1 0.39 11.0 0.1 2.4 2 0 0 2 2 2 0 GAD domain VanZ PF04892.12 EWC45575.1 - 0.07 13.8 0.0 0.091 13.4 0.0 1.2 1 0 0 1 1 1 0 VanZ like family F-box PF00646.33 EWC45576.1 - 0.00017 21.3 0.0 0.00049 19.9 0.0 1.8 1 0 0 1 1 1 1 F-box domain CAP_N PF01213.19 EWC45576.1 - 0.0058 16.2 3.8 0.0093 15.5 3.8 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 EWC45576.1 - 0.1 12.7 4.6 0.17 11.9 4.6 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator F-box-like PF12937.7 EWC45576.1 - 0.11 12.4 0.5 0.47 10.4 0.0 2.3 2 0 0 2 2 2 0 F-box-like Inp1 PF12634.7 EWC45577.1 - 2.2e-21 76.3 0.0 4.8e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 Ribosomal_60s PF00428.19 EWC45577.1 - 0.36 11.4 16.6 0.26 11.9 5.3 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein CENP-B_dimeris PF09026.10 EWC45577.1 - 0.51 10.8 12.5 0.28 11.6 7.8 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EWC45577.1 - 6.3 6.0 6.4 20 4.4 6.4 1.8 1 0 0 1 1 1 0 NOA36 protein Pyr_redox_2 PF07992.14 EWC45578.1 - 2.8e-66 223.7 10.5 4e-66 223.2 10.5 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EWC45578.1 - 2.8e-39 133.8 0.2 8.2e-39 132.3 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EWC45578.1 - 1.8e-20 73.2 13.3 5.4e-19 68.5 1.3 3.6 4 0 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EWC45578.1 - 3.3e-12 46.5 4.2 3.3e-11 43.2 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EWC45578.1 - 8.7e-12 44.8 3.6 8.7e-12 44.8 3.6 2.9 2 1 1 3 3 3 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EWC45578.1 - 8.3e-09 35.1 8.7 1.7e-06 27.5 0.5 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EWC45578.1 - 2e-07 30.5 3.2 2e-07 30.5 3.2 2.7 3 0 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 EWC45578.1 - 9.7e-06 25.7 10.5 0.00021 21.4 0.3 2.9 3 0 0 3 3 2 2 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 EWC45578.1 - 1.3e-05 24.6 7.8 0.0098 15.2 1.0 3.3 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 EWC45578.1 - 3.9e-05 23.0 3.1 0.12 11.5 0.1 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EWC45578.1 - 0.0001 21.6 1.6 0.0001 21.6 1.6 2.6 1 1 1 2 2 2 1 Thi4 family HI0933_like PF03486.14 EWC45578.1 - 0.00021 20.1 18.8 0.00048 18.9 1.8 4.2 4 0 0 4 4 4 2 HI0933-like protein FAD_binding_3 PF01494.19 EWC45578.1 - 0.0004 19.8 13.7 0.025 13.8 1.5 3.1 2 1 1 3 3 3 3 FAD binding domain DAO PF01266.24 EWC45578.1 - 0.0074 15.9 20.0 0.19 11.3 0.6 4.2 3 1 1 4 4 4 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EWC45578.1 - 0.068 12.2 0.1 0.068 12.2 0.1 2.7 3 1 0 3 3 3 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 EWC45578.1 - 0.98 9.9 7.5 1.1 9.7 0.6 3.2 3 2 0 3 3 3 0 Putative NAD(P)-binding MIF4G PF02854.19 EWC45579.1 - 5.2e-23 81.8 0.4 6.4e-21 75.0 0.2 2.2 2 0 0 2 2 2 2 MIF4G domain MA3 PF02847.17 EWC45579.1 - 9.9e-22 77.1 0.0 3.4e-21 75.3 0.0 2.0 1 0 0 1 1 1 1 MA3 domain Dsl1_N PF11988.8 EWC45579.1 - 0.033 13.2 0.3 0.058 12.4 0.3 1.3 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal Bromodomain PF00439.25 EWC45580.1 - 2.8e-39 133.0 3.8 5e-21 74.6 0.1 2.7 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EWC45580.1 - 4.6e-20 71.7 0.5 9.5e-20 70.7 0.5 1.6 1 0 0 1 1 1 1 BAH domain CDC45 PF02724.14 EWC45580.1 - 0.00063 18.2 16.3 0.0012 17.3 16.3 1.4 1 0 0 1 1 1 1 CDC45-like protein DUF913 PF06025.12 EWC45580.1 - 1.1 8.2 3.5 2.2 7.2 3.5 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AT_hook PF02178.19 EWC45580.1 - 4.9 7.4 12.0 10 6.4 3.8 3.1 2 0 0 2 2 2 0 AT hook motif CSN8_PSD8_EIF3K PF10075.9 EWC45581.1 - 1.5e-41 141.7 0.0 2.2e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family DUF4358 PF14270.6 EWC45581.1 - 0.16 12.2 0.1 3.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Sec34 PF04136.15 EWC45582.1 - 2.4e-49 167.1 0.8 5.5e-49 165.9 0.8 1.7 1 0 0 1 1 1 1 Sec34-like family Exo70 PF03081.15 EWC45582.1 - 0.048 12.7 2.7 0.075 12.1 0.1 2.5 3 0 0 3 3 3 0 Exo70 exocyst complex subunit RCC1 PF00415.18 EWC45583.1 - 2.1e-24 85.9 2.0 9.3e-06 26.2 0.0 6.6 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EWC45583.1 - 1.9e-15 56.2 8.6 5.5e-09 35.6 0.0 5.5 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat Suf PF05843.14 EWC45584.1 - 5.7e-83 279.3 0.0 5.7e-83 279.3 0.0 5.4 5 2 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_16 PF13432.6 EWC45584.1 - 2.1e-06 28.2 2.3 0.0023 18.5 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC45584.1 - 4.2e-06 27.2 0.4 0.49 10.9 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC45584.1 - 1.5e-05 25.4 5.7 0.025 15.4 0.1 5.7 5 2 1 6 6 6 1 Tetratricopeptide repeat HAT PF02184.16 EWC45584.1 - 0.051 13.5 0.0 0.051 13.5 0.0 2.6 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat DUF2379 PF09543.10 EWC45584.1 - 0.13 12.5 3.1 0.57 10.4 0.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2379) Piwi PF02171.17 EWC45585.1 - 1.6e-89 300.2 0.2 2.3e-89 299.6 0.2 1.2 1 0 0 1 1 1 1 Piwi domain ArgoL1 PF08699.10 EWC45585.1 - 1.1e-18 66.7 0.1 2.4e-18 65.6 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 EWC45585.1 - 1.3e-17 64.7 0.0 4.8e-17 62.9 0.0 2.1 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 EWC45585.1 - 3.2e-17 62.6 0.6 6.8e-17 61.6 0.6 1.5 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EWC45585.1 - 2.7e-13 50.0 0.0 7.9e-13 48.5 0.0 1.9 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 EWC45585.1 - 1e-12 48.2 0.0 2.1e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain Ank_2 PF12796.7 EWC45586.1 - 7.8e-99 324.4 19.3 1.7e-14 54.1 1.3 12.5 7 3 4 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC45586.1 - 2.2e-77 254.5 18.7 4.8e-08 33.4 0.2 18.8 11 6 8 20 20 20 16 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC45586.1 - 4e-63 201.9 26.4 0.0033 17.8 0.1 26.3 27 0 0 27 27 27 13 Ankyrin repeat Ank_5 PF13857.6 EWC45586.1 - 1.2e-46 156.2 29.9 0.00063 20.0 0.0 20.3 10 5 13 23 23 23 15 Ankyrin repeats (many copies) Ank PF00023.30 EWC45586.1 - 1.2e-46 155.2 48.3 0.0017 18.7 0.1 22.1 24 0 0 24 24 24 12 Ankyrin repeat NACHT PF05729.12 EWC45586.1 - 9.3e-06 25.6 0.0 2.3e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EWC45586.1 - 0.019 15.2 0.0 0.06 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain FLgD_tudor PF13861.6 EWC45586.1 - 0.04 14.2 0.0 0.11 12.7 0.0 1.9 1 1 0 1 1 1 0 FlgD Tudor-like domain MeaB PF03308.16 EWC45586.1 - 0.14 11.2 0.1 3.7 6.4 0.2 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Integrase_H2C2 PF17921.1 EWC45587.1 - 1.4e-12 47.5 0.3 3.6e-12 46.2 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 EWC45587.1 - 5.4e-12 45.7 1.7 1.1e-11 44.8 1.7 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Acetyltransf_1 PF00583.25 EWC45587.1 - 0.0044 17.2 0.0 0.0084 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EWC45587.1 - 0.022 15.4 0.1 0.059 14.0 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain UBA_6 PF18039.1 EWC45587.1 - 0.17 11.9 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain RAM PF15320.6 EWC45587.1 - 1.7 9.3 5.7 0.3 11.7 1.2 2.0 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein Bac_rhodopsin PF01036.18 EWC45588.1 - 2.2e-40 138.6 20.7 2.7e-40 138.3 20.7 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein ASF1_hist_chap PF04729.13 EWC45589.1 - 3.1e-71 238.3 0.0 4.9e-71 237.7 0.0 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone HAD_2 PF13419.6 EWC45590.1 - 3.6e-05 23.9 0.0 0.00017 21.7 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EWC45590.1 - 0.00064 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EWC45590.1 - 0.0023 18.3 0.0 0.0095 16.2 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Nop PF01798.18 EWC45591.1 - 2.9e-89 298.5 0.1 2.9e-89 298.5 0.1 2.3 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EWC45591.1 - 3.4e-19 69.0 0.0 3.4e-19 69.0 0.0 2.8 2 1 0 2 2 2 1 NOP5NT (NUC127) domain TMP-TENI PF02581.17 EWC45591.1 - 0.11 11.8 1.2 0.62 9.4 1.2 2.1 1 1 0 1 1 1 0 Thiamine monophosphate synthase AAA_11 PF13086.6 EWC45591.1 - 0.39 10.5 18.4 0.75 9.5 18.4 1.6 1 0 0 1 1 1 0 AAA domain MDM1 PF15501.6 EWC45591.1 - 0.49 9.5 33.9 0.63 9.1 33.9 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Cpn60_TCP1 PF00118.24 EWC45592.1 - 1.7e-160 534.9 3.1 1.9e-160 534.8 3.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FRQ PF09421.10 EWC45593.1 - 1.2e-69 235.4 23.7 1.1e-45 156.2 10.2 3.2 1 1 1 2 2 2 2 Frequency clock protein F-box PF00646.33 EWC45594.1 - 0.013 15.3 0.1 0.037 13.9 0.1 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EWC45594.1 - 0.052 13.4 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 F-box-like DER1 PF04511.15 EWC45595.1 - 1.8e-55 187.9 6.8 2e-55 187.7 6.8 1.0 1 0 0 1 1 1 1 Der1-like family FA_hydroxylase PF04116.13 EWC45596.1 - 1.2e-22 80.6 16.6 1.2e-22 80.6 16.6 2.4 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily ABC_tran PF00005.27 EWC45597.1 - 7e-18 65.5 0.0 2.4e-17 63.7 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EWC45597.1 - 8.8e-09 35.6 0.9 0.0007 19.5 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EWC45597.1 - 0.00055 19.6 0.2 0.0011 18.7 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EWC45597.1 - 0.0037 16.7 0.0 1.6 8.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EWC45597.1 - 0.018 14.9 0.1 0.028 14.3 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EWC45597.1 - 0.02 14.4 0.3 0.045 13.3 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EWC45597.1 - 0.042 14.3 0.0 0.063 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EWC45597.1 - 0.047 12.7 0.2 0.064 12.2 0.2 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EWC45597.1 - 0.05 14.0 0.6 0.081 13.3 0.5 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF3584 PF12128.8 EWC45597.1 - 0.14 9.6 0.1 0.21 9.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Zeta_toxin PF06414.12 EWC45597.1 - 0.23 10.7 0.2 0.4 9.9 0.2 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_10 PF12846.7 EWC45597.1 - 0.27 10.1 0.1 0.47 9.3 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain 6PF2K PF01591.18 EWC45598.1 - 7.9e-64 215.0 0.0 1.1e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EWC45598.1 - 2.3e-23 82.9 1.0 6.2e-23 81.5 1.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) WD40 PF00400.32 EWC45598.1 - 1e-21 76.8 14.8 0.00034 21.3 0.0 10.7 11 0 0 11 11 11 6 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EWC45598.1 - 0.00016 20.7 0.3 2.2 7.2 0.0 3.5 3 0 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 EWC45599.1 - 3.4e-59 195.4 10.0 1.9e-10 41.2 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC45599.1 - 1.9e-18 66.6 0.1 0.00036 20.8 0.0 6.1 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Tup_N PF08581.10 EWC45599.1 - 1.6e-16 60.4 5.7 2.9e-16 59.5 5.7 1.5 1 0 0 1 1 1 1 Tup N-terminal WD40_like PF17005.5 EWC45599.1 - 1.1e-08 34.8 0.2 8.2e-05 22.1 0.0 5.2 5 1 1 6 6 6 1 WD40-like domain eIF2A PF08662.11 EWC45599.1 - 4.3e-06 26.7 0.0 0.021 14.7 0.0 3.1 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EWC45599.1 - 9.5e-05 21.5 0.1 1.8 7.5 0.0 4.2 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 EWC45599.1 - 0.00031 20.9 0.5 3.7 8.0 0.0 4.8 5 0 0 5 5 5 1 Kelch motif Cytochrom_D1 PF02239.16 EWC45599.1 - 0.00039 19.1 1.8 0.0063 15.1 0.1 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 EWC45599.1 - 0.0018 17.0 0.0 3.9 6.0 0.0 3.5 2 1 2 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 EWC45599.1 - 0.0026 17.7 0.0 19 5.3 0.0 4.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat SHE3 PF17078.5 EWC45599.1 - 0.0047 16.7 3.2 0.0072 16.1 3.2 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Nbas_N PF15492.6 EWC45599.1 - 0.055 12.8 0.1 10 5.3 0.0 2.7 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal TSNAXIP1_N PF15739.5 EWC45599.1 - 0.071 13.5 1.3 0.13 12.6 1.3 1.3 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus MMS1_N PF10433.9 EWC45599.1 - 0.11 11.1 0.0 8.3 4.9 0.0 2.2 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term zf-C2H2 PF00096.26 EWC45600.1 - 2.3e-14 52.9 22.5 0.00054 20.3 0.4 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC45600.1 - 3.3e-09 36.7 7.4 7.3e-08 32.5 1.8 5.4 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC45600.1 - 8e-06 26.3 21.3 0.16 12.9 0.3 5.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EWC45600.1 - 0.0034 17.6 4.2 1.4 9.0 0.1 3.3 2 1 1 3 3 3 2 Aberrant zinc-finger C1_4 PF07975.12 EWC45600.1 - 0.11 12.7 3.7 0.4 11.0 0.2 2.9 3 0 0 3 3 3 0 TFIIH C1-like domain GED PF02212.18 EWC45600.1 - 0.82 9.9 12.7 9.2 6.5 0.6 4.2 1 1 4 5 5 5 0 Dynamin GTPase effector domain DUF637 PF04830.13 EWC45600.1 - 5.5 6.8 23.9 3.3 7.5 4.0 3.6 1 1 2 3 3 3 0 Possible hemagglutinin (DUF637) zf-C2H2 PF00096.26 EWC45601.1 - 1.9 9.1 10.4 5.6 7.6 0.2 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type Ribosomal_L2_C PF03947.18 EWC45602.1 - 1.7e-42 144.6 3.6 2.8e-42 143.9 3.6 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EWC45602.1 - 2.1e-14 53.2 0.1 5.4e-14 51.9 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain SNF2_N PF00176.23 EWC45603.1 - 2.7e-72 243.4 0.1 2.7e-72 243.4 0.1 2.8 3 1 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC45603.1 - 6.7e-20 71.5 0.5 4.3e-18 65.7 0.0 3.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EWC45603.1 - 2.5e-19 69.1 0.3 6e-19 67.9 0.3 1.6 1 0 0 1 1 1 1 Bromodomain HSA PF07529.13 EWC45603.1 - 2.1e-15 56.8 6.5 2.1e-15 56.8 6.5 4.8 3 2 1 4 4 4 1 HSA SnAC PF14619.6 EWC45603.1 - 2.1e-13 50.7 3.3 2.1e-13 50.7 3.3 5.2 6 1 0 6 6 6 1 Snf2-ATP coupling, chromatin remodelling complex MMR_HSR1_Xtn PF16897.5 EWC45604.1 - 3.3e-35 120.3 0.4 9.5e-35 118.8 0.3 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EWC45604.1 - 2.2e-21 75.7 0.0 5.1e-21 74.5 0.0 1.7 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EWC45604.1 - 5.1e-21 74.9 0.0 9.6e-21 74.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EWC45604.1 - 8.1e-14 51.4 0.0 1.3e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EWC45604.1 - 0.00041 20.4 0.2 0.039 14.0 0.0 2.3 1 1 1 2 2 2 1 Dynamin family NB-ARC PF00931.22 EWC45604.1 - 0.034 13.3 0.0 0.12 11.6 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain MCM PF00493.23 EWC45604.1 - 0.074 12.1 0.1 0.15 11.1 0.0 1.6 2 0 0 2 2 2 0 MCM P-loop domain AIG1 PF04548.16 EWC45604.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 AIG1 family AAA_16 PF13191.6 EWC45604.1 - 0.15 12.5 0.3 0.47 10.8 0.2 1.9 2 1 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 EWC45604.1 - 0.3 10.6 1.4 11 5.5 0.0 3.1 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EWC45605.1 - 5.5e-10 39.3 1.3 1.1e-09 38.3 0.2 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EWC45605.1 - 0.00044 19.6 0.4 0.00087 18.7 0.0 1.6 2 0 0 2 2 2 1 AIG1 family FeoB_N PF02421.18 EWC45605.1 - 0.00086 18.9 2.1 0.0014 18.2 0.1 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EWC45605.1 - 0.0014 18.5 1.0 0.0033 17.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EWC45605.1 - 0.0024 17.9 5.2 0.086 12.9 0.1 3.2 2 1 1 3 3 3 1 Dynamin family DLIC PF05783.11 EWC45605.1 - 0.0026 16.7 0.1 0.0056 15.6 0.1 1.5 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Septin PF00735.18 EWC45605.1 - 0.0038 16.6 2.3 0.011 15.1 1.5 2.2 1 1 0 1 1 1 1 Septin GrpE PF01025.19 EWC45605.1 - 0.0047 16.6 1.5 0.0085 15.8 1.5 1.4 1 0 0 1 1 1 1 GrpE NB-ARC PF00931.22 EWC45605.1 - 0.02 14.1 1.1 0.048 12.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain SRPRB PF09439.10 EWC45605.1 - 0.036 13.5 0.1 0.078 12.4 0.1 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TsaE PF02367.17 EWC45605.1 - 0.038 14.0 0.0 0.45 10.5 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EWC45605.1 - 0.051 12.6 1.5 1.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF1003 PF06210.11 EWC45605.1 - 0.15 12.2 5.1 0.35 11.0 5.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) AAA_33 PF13671.6 EWC45605.1 - 0.26 11.5 1.5 3 8.0 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EWC45605.1 - 0.33 10.6 2.6 0.89 9.2 0.1 2.4 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 EWC45605.1 - 0.7 9.6 6.5 0.41 10.4 0.9 2.6 1 1 1 3 3 3 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 EWC45605.1 - 0.76 10.3 4.2 0.39 11.2 0.5 2.3 2 1 0 2 2 2 0 ABC transporter Jnk-SapK_ap_N PF09744.9 EWC45605.1 - 1.2 9.4 10.7 4.7 7.4 10.4 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 MMR_HSR1 PF01926.23 EWC45606.1 - 9.9e-10 38.5 1.8 1.4e-09 38.0 0.2 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EWC45606.1 - 4.1e-05 23.0 0.1 4.1e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 AIG1 family SAM_MT PF04445.13 EWC45606.1 - 0.0021 17.5 0.3 0.015 14.7 0.0 2.1 2 0 0 2 2 2 1 Putative SAM-dependent methyltransferase RsgA_GTPase PF03193.16 EWC45606.1 - 0.0083 16.0 0.2 0.0083 16.0 0.2 1.8 2 0 0 2 2 2 1 RsgA GTPase Arf PF00025.21 EWC45606.1 - 0.012 15.0 1.1 0.22 10.9 0.1 2.7 2 1 1 3 3 3 0 ADP-ribosylation factor family NB-ARC PF00931.22 EWC45606.1 - 0.028 13.6 0.2 0.028 13.6 0.2 2.0 3 0 0 3 3 3 0 NB-ARC domain AAA_22 PF13401.6 EWC45606.1 - 0.049 13.9 0.1 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EWC45606.1 - 0.087 13.3 0.9 0.26 11.8 0.0 2.1 2 0 0 2 2 2 0 ABC transporter IIGP PF05049.13 EWC45606.1 - 0.096 11.7 5.5 0.22 10.5 0.4 2.2 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 EWC45606.1 - 0.14 11.7 1.3 0.19 11.3 0.1 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EWC45606.1 - 0.3 11.1 6.2 20 5.2 0.1 3.3 2 1 1 3 3 3 0 Dynamin family Enkurin PF13864.6 EWC45606.1 - 0.56 10.7 7.7 1.2 9.6 7.7 1.5 1 0 0 1 1 1 0 Calmodulin-binding Spectrin_like PF18373.1 EWC45606.1 - 0.71 10.0 3.0 0.46 10.6 0.8 1.8 2 0 0 2 2 2 0 Spectrin like domain ABC_membrane PF00664.23 EWC45608.1 - 1.8e-61 208.2 14.7 6.2e-44 150.7 0.8 3.6 3 1 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EWC45608.1 - 1.2e-54 184.6 0.0 5.9e-31 107.8 0.0 2.8 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EWC45608.1 - 2.3e-07 30.9 0.2 0.019 14.8 0.0 3.5 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EWC45608.1 - 3.1e-07 30.0 2.8 0.1 12.1 0.1 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EWC45608.1 - 4.9e-06 27.2 9.5 7.9e-05 23.2 0.1 3.2 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 EWC45608.1 - 3.2e-05 24.0 1.2 0.048 13.8 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EWC45608.1 - 3.4e-05 24.3 0.1 0.14 12.5 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EWC45608.1 - 0.00022 21.2 0.2 0.24 11.3 0.1 2.8 2 0 0 2 2 2 1 RsgA GTPase IstB_IS21 PF01695.17 EWC45608.1 - 0.00043 20.1 0.0 0.95 9.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 EWC45608.1 - 0.00049 20.4 0.3 4.6 7.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EWC45608.1 - 0.00051 19.7 0.1 0.91 9.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EWC45608.1 - 0.00075 19.7 1.1 0.085 12.9 0.1 3.1 3 0 0 3 3 2 1 Helicase HerA, central domain Zeta_toxin PF06414.12 EWC45608.1 - 0.0013 18.1 0.2 1.5 8.1 0.1 2.5 2 0 0 2 2 2 2 Zeta toxin AAA PF00004.29 EWC45608.1 - 0.0049 17.3 0.1 6.2 7.3 0.0 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EWC45608.1 - 0.0056 16.3 0.8 0.33 10.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain T2SSE PF00437.20 EWC45608.1 - 0.0079 15.3 0.1 0.065 12.3 0.1 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EWC45608.1 - 0.0093 15.7 0.8 2.4 7.8 0.1 2.7 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EWC45608.1 - 0.014 14.4 0.0 0.025 13.6 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TrwB_AAD_bind PF10412.9 EWC45608.1 - 0.018 14.0 0.4 0.93 8.3 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 EWC45608.1 - 0.026 15.1 0.9 3.4 8.2 0.1 3.1 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EWC45608.1 - 0.035 14.5 0.2 10 6.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase FtsK_SpoIIIE PF01580.18 EWC45608.1 - 0.054 12.8 0.4 1.1 8.6 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF2075 PF09848.9 EWC45608.1 - 0.07 12.4 0.3 7.6 5.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Adeno_IVa2 PF02456.15 EWC45608.1 - 0.11 11.3 0.0 0.44 9.3 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein DUF815 PF05673.13 EWC45608.1 - 0.15 11.2 0.1 0.97 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 EWC45608.1 - 0.15 11.8 1.4 0.85 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 EWC45608.1 - 0.19 11.8 0.4 3.2 7.8 0.0 2.9 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 EWC45608.1 - 0.25 10.9 2.6 0.73 9.4 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EWC45608.1 - 0.35 10.8 1.7 5.8 6.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 EWC45608.1 - 0.48 10.3 2.1 0.99 9.3 0.0 2.5 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.23 EWC45608.1 - 2.6 8.1 4.6 19 5.3 0.1 2.9 3 0 0 3 3 2 0 Dynamin family SPATA25 PF15218.6 EWC45609.1 - 0.008 16.0 0.7 0.0096 15.7 0.7 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated protein 25 Asp PF00026.23 EWC45610.1 - 4.7e-29 101.8 0.0 6.4e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease ORC2 PF04084.14 EWC45611.1 - 3.9e-103 344.9 0.0 5.1e-103 344.5 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 BUD22 PF09073.10 EWC45611.1 - 0.13 11.5 6.1 0.2 10.9 6.1 1.2 1 0 0 1 1 1 0 BUD22 ORC6 PF05460.13 EWC45611.1 - 4.9 6.3 11.7 0.06 12.6 1.5 2.1 1 1 1 2 2 2 0 Origin recognition complex subunit 6 (ORC6) ArgJ PF01960.18 EWC45612.1 - 8.4e-143 475.6 1.5 9.5e-143 475.5 1.5 1.0 1 0 0 1 1 1 1 ArgJ family ATP-grasp PF02222.22 EWC45612.1 - 0.076 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain Pep3_Vps18 PF05131.14 EWC45613.1 - 9.9e-39 132.5 0.7 4.5e-38 130.4 0.0 2.4 3 0 0 3 3 3 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EWC45613.1 - 2.5e-08 33.9 13.0 4.2e-07 29.9 0.5 3.2 4 0 0 4 4 3 2 Region in Clathrin and VPS Zn_ribbon_17 PF17120.5 EWC45613.1 - 0.00041 19.9 0.3 0.00091 18.8 0.3 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EWC45613.1 - 0.0011 19.3 0.5 0.0022 18.3 0.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC45613.1 - 0.0016 18.2 0.9 0.0034 17.2 0.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RPN1_RPN2_N PF17781.1 EWC45613.1 - 0.0041 16.6 0.3 0.01 15.3 0.0 1.7 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain Vps39_2 PF10367.9 EWC45613.1 - 0.0047 17.4 0.5 0.014 15.8 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-RING_5 PF14634.6 EWC45613.1 - 0.0059 16.5 0.6 0.012 15.6 0.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DUF713 PF05218.14 EWC45613.1 - 0.013 15.3 0.1 1.4 8.6 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF713) zf-RING_11 PF17123.5 EWC45613.1 - 0.017 14.9 4.5 0.036 13.8 4.5 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 EWC45613.1 - 0.018 15.3 0.2 0.041 14.2 0.2 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EWC45613.1 - 0.047 13.7 0.7 0.095 12.7 0.7 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Filament PF00038.21 EWC45613.1 - 0.058 13.0 0.6 0.38 10.3 0.1 2.1 2 0 0 2 2 2 0 Intermediate filament protein zf-C3HC4 PF00097.25 EWC45613.1 - 0.13 12.2 0.1 0.13 12.2 0.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 EWC45613.1 - 0.18 11.9 2.4 0.36 10.9 2.4 1.5 1 0 0 1 1 1 0 Zinc-finger Pkinase PF00069.25 EWC45614.1 - 1e-67 228.3 0.0 1.6e-67 227.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45614.1 - 3.1e-49 167.6 0.0 6.3e-49 166.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EWC45614.1 - 5.3e-25 87.7 0.0 1.1e-24 86.7 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 EWC45614.1 - 1.4e-17 63.6 0.0 3.2e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EWC45614.1 - 8.7e-17 61.3 0.0 1.8e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 EWC45614.1 - 2.2e-06 27.2 0.0 0.00033 20.1 0.0 2.4 2 0 0 2 2 2 1 Kinase-like RA PF00788.23 EWC45614.1 - 0.00013 22.5 0.0 0.00024 21.7 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Jun PF03957.13 EWC45614.1 - 0.002 18.1 1.1 0.0053 16.7 0.0 2.2 2 0 0 2 2 2 1 Jun-like transcription factor Pkinase_fungal PF17667.1 EWC45614.1 - 0.014 14.2 0.1 0.034 12.9 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase SAM_4 PF18017.1 EWC45614.1 - 0.041 13.9 0.0 0.09 12.8 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Nop14 PF04147.12 EWC45614.1 - 7.7 4.6 20.0 14 3.7 20.0 1.4 1 0 0 1 1 1 0 Nop14-like family SAC3_GANP PF03399.16 EWC45615.1 - 5e-76 255.9 0.2 7.5e-76 255.3 0.2 1.3 1 0 0 1 1 1 1 SAC3/GANP family Nucleoporin_FG PF13634.6 EWC45615.1 - 0.0028 18.5 42.6 0.056 14.3 2.6 5.9 3 2 3 6 6 6 5 Nucleoporin FG repeat region CLTH PF10607.9 EWC45616.1 - 1.9e-33 115.4 0.2 3.7e-33 114.5 0.0 1.6 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EWC45616.1 - 0.0015 18.4 0.0 0.0038 17.1 0.0 1.8 1 0 0 1 1 1 1 LisH SecY PF00344.20 EWC45618.1 - 1.3e-73 247.9 9.2 1.6e-73 247.6 9.2 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EWC45618.1 - 2e-17 62.7 0.3 6e-17 61.2 0.3 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p Importin_rep_3 PF18806.1 EWC45619.1 - 3.8e-06 26.9 0.2 6.4e-05 22.9 0.3 2.9 2 1 0 2 2 2 1 Importin 13 repeat Importin_rep PF18773.1 EWC45619.1 - 4.1e-05 23.2 0.4 0.00012 21.7 0.1 2.1 2 0 0 2 2 2 1 Importin 13 repeat Myb_DNA-bind_7 PF15963.5 EWC45620.1 - 6.7e-21 74.0 1.3 1.1e-20 73.3 1.3 1.3 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EWC45620.1 - 0.00023 21.3 0.0 0.00042 20.4 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain BRE1 PF08647.11 EWC45621.1 - 2.9e-15 56.1 15.0 2.9e-15 56.1 15.0 6.5 4 1 2 7 7 6 1 BRE1 E3 ubiquitin ligase Prok-RING_4 PF14447.6 EWC45621.1 - 1.2e-07 31.5 6.7 2.1e-07 30.7 6.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EWC45621.1 - 8.4e-07 28.8 8.5 1.5e-06 28.0 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EWC45621.1 - 4.7e-06 26.3 7.9 8.8e-06 25.5 7.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC45621.1 - 5e-06 26.3 9.0 9.6e-06 25.4 9.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC45621.1 - 5.7e-06 26.6 8.3 1.1e-05 25.7 8.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EWC45621.1 - 3.8e-05 23.6 9.0 7.7e-05 22.6 9.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EWC45621.1 - 0.0004 20.4 5.1 0.0009 19.2 5.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C2HC_2 PF13913.6 EWC45621.1 - 0.0024 17.7 0.1 0.0061 16.4 0.1 1.7 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-rbx1 PF12678.7 EWC45621.1 - 0.012 15.9 4.8 0.038 14.3 4.8 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-UDP PF14569.6 EWC45621.1 - 0.49 10.5 3.7 1.2 9.3 3.7 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 EWC45621.1 - 0.5 10.2 7.0 1 9.2 7.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EWC45621.1 - 0.57 10.1 4.2 1.3 9.0 4.2 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EWC45621.1 - 0.71 10.1 6.6 1.8 8.8 6.6 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DZR PF12773.7 EWC45621.1 - 1.7 8.7 4.9 4.2 7.5 4.9 1.6 1 0 0 1 1 1 0 Double zinc ribbon Cupin_5 PF06172.11 EWC45622.1 - 3.8e-43 147.0 0.0 5e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) DUF2431 PF10354.9 EWC45623.1 - 2.5e-49 167.8 0.0 3.2e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) TALPID3 PF15324.6 EWC45623.1 - 0.24 9.0 7.6 0.32 8.6 7.6 1.0 1 0 0 1 1 1 0 Hedgehog signalling target GREB1 PF15782.5 EWC45623.1 - 5 4.1 5.3 5.8 3.9 5.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MGC-24 PF05283.11 EWC45623.1 - 9.9 6.6 8.6 26 5.3 4.8 2.2 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin ABC_membrane PF00664.23 EWC45624.1 - 4e-98 328.4 33.7 1.7e-50 172.2 12.0 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EWC45624.1 - 9.2e-70 233.5 0.2 3.1e-34 118.4 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 EWC45624.1 - 1.4e-15 57.3 2.5 2.5e-05 23.8 0.0 4.2 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EWC45624.1 - 1.1e-06 28.3 1.4 0.0068 16.1 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EWC45624.1 - 2e-06 27.8 0.0 0.12 12.3 0.0 3.2 3 0 0 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EWC45624.1 - 2e-05 25.0 10.4 0.034 14.5 0.2 4.0 2 2 0 3 3 3 2 AAA ATPase domain ABC_ATPase PF09818.9 EWC45624.1 - 2.3e-05 23.4 2.2 0.034 13.0 0.0 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA PF00004.29 EWC45624.1 - 7e-05 23.3 3.0 0.068 13.6 0.0 4.3 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EWC45624.1 - 0.00028 20.2 0.4 0.35 10.1 0.0 3.2 3 0 0 3 3 3 1 Zeta toxin AAA_25 PF13481.6 EWC45624.1 - 0.00049 19.7 1.5 0.18 11.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EWC45624.1 - 0.00063 19.6 0.0 0.73 9.5 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EWC45624.1 - 0.00063 19.3 0.0 0.59 9.6 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 EWC45624.1 - 0.00071 19.9 3.5 0.45 10.8 0.2 3.9 2 2 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EWC45624.1 - 0.0013 18.7 0.5 2.7 8.0 0.0 3.9 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EWC45624.1 - 0.0019 17.9 7.1 0.6 9.8 0.1 3.9 5 0 0 5 5 5 2 AAA domain DUF87 PF01935.17 EWC45624.1 - 0.0026 17.9 0.7 0.42 10.7 0.0 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_21 PF13304.6 EWC45624.1 - 0.0036 17.2 2.7 2 8.1 0.0 3.6 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system GARS_C PF02843.16 EWC45624.1 - 0.0054 17.0 0.3 0.68 10.3 0.1 2.8 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain SbcCD_C PF13558.6 EWC45624.1 - 0.0055 16.9 2.5 3.4 8.0 0.1 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 EWC45624.1 - 0.0086 16.0 0.2 0.039 13.9 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_33 PF13671.6 EWC45624.1 - 0.0091 16.2 0.0 7.2 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EWC45624.1 - 0.012 16.1 1.3 3.9 7.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.20 EWC45624.1 - 0.014 14.6 0.0 5.8 6.0 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_28 PF13521.6 EWC45624.1 - 0.022 15.0 0.1 4.9 7.4 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EWC45624.1 - 0.023 15.2 0.0 7.9 7.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain Dala_Dala_lig_N PF01820.21 EWC45624.1 - 0.047 14.2 0.0 18 5.8 0.0 2.7 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_24 PF13479.6 EWC45624.1 - 0.093 12.4 0.2 5.4 6.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EWC45624.1 - 0.12 12.7 0.3 6.9 7.1 0.0 3.0 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.20 EWC45624.1 - 0.13 12.2 2.1 1.5 8.7 0.1 2.9 3 0 0 3 3 3 0 Adenylylsulphate kinase Ribosomal_L39 PF00832.20 EWC45625.1 - 6.6e-21 73.7 10.1 7.4e-21 73.5 10.1 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Ytp1 PF10355.9 EWC45626.1 - 3e-60 203.8 25.0 3e-60 203.8 25.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EWC45626.1 - 7.1e-28 96.5 0.9 7.1e-28 96.5 0.9 3.5 5 0 0 5 5 5 1 Domain of unknown function (DUF2427) Pept_tRNA_hydro PF01195.19 EWC45627.1 - 1.9e-31 109.3 0.0 5.2e-31 107.9 0.0 1.6 2 0 0 2 2 2 1 Peptidyl-tRNA hydrolase Mito_fiss_reg PF05308.11 EWC45627.1 - 0.15 12.1 2.2 0.23 11.5 2.2 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Peptidase_S9_N PF02897.15 EWC45627.1 - 0.2 10.4 0.0 0.27 10.0 0.0 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain SMN PF06003.12 EWC45627.1 - 0.2 10.9 0.3 0.28 10.4 0.3 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Rrn6 PF10214.9 EWC45627.1 - 1.2 7.5 5.5 1.6 7.1 5.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CAP_N PF01213.19 EWC45627.1 - 2.6 7.4 4.1 4 6.8 4.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal YibE_F PF07907.11 EWC45628.1 - 0.086 12.3 0.4 0.15 11.6 0.1 1.4 1 1 0 1 1 1 0 YibE/F-like protein YibE_F PF07907.11 EWC45629.1 - 0.086 12.3 0.4 0.15 11.6 0.1 1.4 1 1 0 1 1 1 0 YibE/F-like protein Sec8_exocyst PF04048.14 EWC45630.1 - 2.2e-41 141.1 0.0 7e-41 139.4 0.0 1.9 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EWC45630.1 - 5e-07 29.3 0.2 1.1e-06 28.1 0.2 1.5 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EWC45630.1 - 0.0033 17.2 0.1 0.019 14.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Occludin_ELL PF07303.13 EWC45630.1 - 0.063 14.0 0.1 0.45 11.3 0.0 2.5 2 0 0 2 2 2 0 Occludin homology domain Creatinase_N_2 PF16189.5 EWC45631.1 - 2.6e-45 154.4 0.0 1.3e-43 148.9 0.0 2.8 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EWC45631.1 - 7.5e-45 153.2 0.0 1.1e-44 152.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EWC45631.1 - 7.2e-24 83.6 0.6 1.8e-23 82.4 0.6 1.7 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EWC45631.1 - 7.6e-21 75.1 0.0 5e-19 69.3 0.0 2.6 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Methyltransf_24 PF13578.6 EWC45632.1 - 3.2e-16 60.2 0.1 9.1e-14 52.4 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_3 PF01596.17 EWC45632.1 - 3.2e-05 23.2 0.0 4.5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase GCD14 PF08704.10 EWC45632.1 - 0.019 14.6 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit CmcI PF04989.12 EWC45632.1 - 0.15 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase DUF685 PF05085.12 EWC45632.1 - 0.16 11.3 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF685) DUF3606 PF12244.8 EWC45635.1 - 0.11 12.5 0.1 0.29 11.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) PolyA_pol_arg_C PF12626.7 EWC45637.1 - 0.00057 19.9 0.8 0.00096 19.2 0.8 1.4 1 0 0 1 1 1 1 Polymerase A arginine-rich C-terminus LapA_dom PF06305.11 EWC45637.1 - 1.8 8.5 4.3 0.47 10.3 0.8 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain F-box PF00646.33 EWC45638.1 - 1.2e-06 28.2 1.2 1.2e-06 28.2 1.2 1.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EWC45638.1 - 3.9e-06 26.7 0.4 8.4e-06 25.6 0.4 1.5 1 0 0 1 1 1 1 F-box-like Lsr2 PF11774.8 EWC45640.1 - 0.69 10.1 6.6 1.3 9.2 4.1 2.0 1 1 1 2 2 2 0 Lsr2 EMC3_TMCO1 PF01956.16 EWC45640.1 - 8.4 6.1 7.6 63 3.2 7.6 2.0 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Herpes_gE PF02480.16 EWC45641.1 - 0.089 11.5 0.1 0.13 10.9 0.1 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E AbiEii PF08843.11 EWC45643.1 - 0.00078 19.5 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system Glu_syn_central PF04898.14 EWC45644.1 - 0.0088 15.6 0.2 0.013 15.0 0.2 1.1 1 0 0 1 1 1 1 Glutamate synthase central domain Cytomega_UL20A PF05984.12 EWC45644.1 - 0.043 14.1 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein TauD PF02668.16 EWC45646.1 - 1.4e-44 152.9 0.0 1.8e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Plasmod_MYXSPDY PF07981.11 EWC45646.1 - 0.029 14.3 0.3 0.057 13.4 0.3 1.4 1 0 0 1 1 1 0 Plasmodium repeat_MYXSPDY Ax_dynein_light PF10211.9 EWC45646.1 - 0.05 13.5 0.0 0.079 12.9 0.0 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Myb_DNA-bind_6 PF13921.6 EWC45647.1 - 1.1e-05 25.5 0.0 2.7e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EWC45647.1 - 0.0011 19.0 0.8 0.013 15.7 0.0 2.4 2 1 0 2 2 2 1 Myb-like DNA-binding domain Rap1_C PF11626.8 EWC45647.1 - 0.0018 18.3 0.1 0.0029 17.7 0.1 1.5 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain CAP PF00188.26 EWC45648.1 - 6.4e-15 56.1 6.1 2.1e-14 54.5 6.1 1.8 1 1 0 1 1 1 1 Cysteine-rich secretory protein family zf-C3HC4 PF00097.25 EWC45649.1 - 0.7 9.8 5.9 2 8.4 5.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC45649.1 - 1.5 8.9 8.5 3.4 7.7 8.5 1.7 1 0 0 1 1 1 0 zinc-RING finger domain IBR PF01485.21 EWC45650.1 - 7.3e-07 29.3 23.9 0.00011 22.4 11.2 3.4 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-ACC PF17848.1 EWC45650.1 - 0.046 13.8 0.5 0.046 13.8 0.5 2.7 2 1 1 3 3 3 0 Acetyl-coA carboxylase zinc finger domain IBR PF01485.21 EWC45651.1 - 2.8e-07 30.7 35.3 1.5e-05 25.1 11.6 3.7 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EWC45651.1 - 0.004 17.0 8.3 0.004 17.0 8.3 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EWC45651.1 - 0.0086 15.9 6.3 0.0086 15.9 6.3 4.5 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Cript PF10235.9 EWC45651.1 - 0.01 16.4 2.5 0.01 16.4 2.5 4.5 5 0 0 5 5 5 1 Microtubule-associated protein CRIPT HopA1 PF17914.1 EWC45651.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 HopA1 effector protein family MFS_1 PF07690.16 EWC45653.1 - 4.1e-23 81.9 20.8 4.1e-23 81.9 20.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EWC45653.1 - 4.3e-11 42.8 4.4 4.3e-11 42.8 4.4 2.2 2 1 0 2 2 2 1 Nodulin-like ZYG-11_interact PF05884.12 EWC45653.1 - 0.34 10.3 4.7 0.68 9.3 1.3 2.3 2 0 0 2 2 2 0 Interactor of ZYG-11 DUF4635 PF15466.6 EWC45654.1 - 0.064 12.8 0.4 0.11 12.1 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) CFEM PF05730.11 EWC45655.1 - 6.1e-10 39.1 9.0 1e-09 38.3 9.0 1.3 1 0 0 1 1 1 1 CFEM domain SKG6 PF08693.10 EWC45655.1 - 0.055 12.9 3.7 0.15 11.5 3.7 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Sporozoite_P67 PF05642.11 EWC45655.1 - 0.085 10.9 6.6 0.092 10.8 6.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2273 PF10031.9 EWC45655.1 - 0.25 11.4 4.6 0.48 10.5 4.6 1.4 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) MGC-24 PF05283.11 EWC45655.1 - 1.7 9.1 13.3 5.4 7.5 13.3 1.8 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin ADH_N PF08240.12 EWC45656.1 - 1.2e-27 95.9 2.1 2.6e-27 94.9 2.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC45656.1 - 9.8e-10 38.5 1.7 1.7e-07 31.2 0.0 3.0 2 1 1 3 3 3 2 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EWC45656.1 - 0.00032 20.5 0.4 0.00067 19.5 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated 2-Hacid_dh_C PF02826.19 EWC45656.1 - 0.076 12.4 0.0 0.18 11.2 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 EWC45657.1 - 2.2e-49 168.1 0.1 3.4e-49 167.5 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EWC45657.1 - 3.3e-47 160.5 0.3 5.1e-47 159.9 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EWC45657.1 - 1.4e-08 34.8 1.2 1.5e-07 31.5 1.2 2.2 1 1 0 1 1 1 1 KR domain Pyr_redox PF00070.27 EWC45657.1 - 0.00021 21.8 0.2 0.00047 20.7 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EWC45657.1 - 0.00057 19.8 1.1 0.0017 18.3 1.1 1.8 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 EWC45657.1 - 0.0011 18.5 0.2 0.0077 15.7 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EWC45657.1 - 0.0022 17.2 0.6 0.0033 16.6 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EWC45657.1 - 0.0066 15.9 0.5 0.018 14.5 0.0 1.9 2 1 1 3 3 3 1 GDP-mannose 4,6 dehydratase Glyco_tran_WecB PF03808.13 EWC45657.1 - 0.0068 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family ADH_zinc_N PF00107.26 EWC45657.1 - 0.016 15.2 0.1 0.03 14.3 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF1776 PF08643.10 EWC45657.1 - 0.023 14.1 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EWC45657.1 - 0.025 14.1 0.2 0.041 13.4 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family Pyr_redox_2 PF07992.14 EWC45657.1 - 0.036 13.3 0.0 0.068 12.4 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 EWC45657.1 - 0.067 13.2 0.1 0.48 10.4 0.0 2.0 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 EWC45657.1 - 0.096 13.0 0.2 0.17 12.2 0.2 1.3 1 0 0 1 1 1 0 TrkA-N domain HI0933_like PF03486.14 EWC45657.1 - 0.12 11.1 1.3 0.41 9.3 1.0 1.9 2 0 0 2 2 2 0 HI0933-like protein Pilin_N PF07790.11 EWC45658.1 - 0.0029 18.5 0.8 0.0069 17.3 0.8 1.7 1 0 0 1 1 1 1 Archaeal Type IV pilin, N-terminal MacB_PCD PF12704.7 EWC45658.1 - 0.059 13.7 0.5 0.54 10.6 0.1 2.4 2 0 0 2 2 2 0 MacB-like periplasmic core domain UvdE PF03851.14 EWC45659.1 - 1.1e-80 270.9 0.0 6.4e-58 196.2 0.0 2.2 1 1 1 2 2 2 2 UV-endonuclease UvdE CD34_antigen PF06365.12 EWC45660.1 - 0.037 13.6 0.5 0.072 12.7 0.0 1.6 2 0 0 2 2 2 0 CD34/Podocalyxin family DUF3325 PF11804.8 EWC45660.1 - 0.089 12.9 0.4 0.13 12.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3325) Peptidase_S8 PF00082.22 EWC45661.1 - 1.1e-23 84.0 3.9 3.2e-23 82.4 3.9 1.6 1 1 0 1 1 1 1 Subtilase family Ank PF00023.30 EWC45662.1 - 2.8e-18 65.4 3.9 0.0057 17.1 0.0 6.3 5 1 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EWC45662.1 - 5.5e-18 65.1 0.1 0.00092 19.7 0.0 6.5 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EWC45662.1 - 2.5e-15 56.8 0.0 0.00012 22.6 0.0 4.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EWC45662.1 - 2.1e-14 53.4 3.3 0.018 15.4 0.1 6.4 5 1 0 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC45662.1 - 6.7e-12 44.5 2.7 0.033 14.7 0.0 7.2 6 0 0 6 6 6 3 Ankyrin repeat PNP_UDP_1 PF01048.20 EWC45662.1 - 6.2e-08 32.2 0.1 1.9e-07 30.6 0.1 1.9 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 EWC45662.1 - 1.4e-06 28.4 0.1 2.7e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EWC45662.1 - 4.7e-05 23.8 0.1 0.0002 21.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EWC45662.1 - 0.0034 17.1 0.0 0.007 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EWC45662.1 - 0.022 15.1 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EWC45662.1 - 0.033 13.4 1.3 0.16 11.2 0.1 2.0 1 1 0 2 2 2 0 KAP family P-loop domain AAA_22 PF13401.6 EWC45662.1 - 0.06 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EWC45662.1 - 0.099 13.0 0.1 0.38 11.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_29 PF13555.6 EWC45662.1 - 0.17 11.6 0.0 0.47 10.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pirin PF02678.16 EWC45664.1 - 1.6e-26 92.4 0.1 2.7e-26 91.6 0.1 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EWC45664.1 - 9.2e-26 90.2 0.0 3e-25 88.6 0.0 1.8 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EWC45664.1 - 0.018 14.7 0.7 0.18 11.6 0.4 2.3 2 0 0 2 2 2 0 Cupin domain Pirin_C_2 PF17954.1 EWC45664.1 - 0.1 12.8 0.0 0.27 11.5 0.0 1.7 2 0 0 2 2 2 0 Quercetinase C-terminal cupin domain IPK PF03770.16 EWC45665.1 - 1.8e-49 168.3 0.0 4.4e-49 167.0 0.0 1.7 1 0 0 1 1 1 1 Inositol polyphosphate kinase TFIID_30kDa PF03540.13 EWC45666.1 - 4.2e-26 90.6 0.3 6.7e-26 90.0 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit DUF4199 PF13858.6 EWC45668.1 - 0.049 14.0 0.1 0.087 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) MFS_1 PF07690.16 EWC45669.1 - 1.1e-20 73.9 52.7 3.1e-20 72.4 52.7 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EWC45669.1 - 5.8e-10 38.2 14.1 5.8e-10 38.2 14.1 2.0 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) WTF PF03303.13 EWC45669.1 - 0.29 10.8 2.1 0.66 9.7 2.1 1.6 1 0 0 1 1 1 0 WTF protein OATP PF03137.20 EWC45669.1 - 7 4.8 20.5 20 3.3 20.5 1.9 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family RRM_1 PF00076.22 EWC45670.1 - 2e-13 49.9 0.0 3.4e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EWC45670.1 - 6.6e-06 26.6 6.3 6.6e-06 26.6 6.3 2.9 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 MFS_1 PF07690.16 EWC45671.1 - 1.6e-45 155.6 30.5 1.9e-45 155.3 30.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EWC45671.1 - 7.7e-09 34.5 3.3 1.2e-08 33.9 3.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EWC45671.1 - 1.8e-08 33.7 15.3 5.3e-08 32.2 15.1 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2178 PF09946.9 EWC45671.1 - 3.2 8.0 9.7 19 5.5 3.7 3.2 2 1 1 3 3 3 0 Predicted membrane protein (DUF2178) DFRP_C PF16543.5 EWC45673.1 - 2e-23 82.7 11.5 2e-23 82.7 11.5 3.3 4 1 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 EWC45673.1 - 4.3e-06 27.4 15.0 7e-06 26.7 3.4 3.6 3 2 0 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 EWC45673.1 - 9.9e-06 25.4 5.2 9.9e-06 25.4 5.2 3.0 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH PF00642.24 EWC45673.1 - 7.6e-05 22.5 1.7 0.00032 20.5 0.8 2.3 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EWC45673.1 - 0.00017 21.3 7.7 0.00054 19.7 1.2 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EWC45673.1 - 0.00024 21.3 0.4 0.047 13.9 0.1 2.7 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EWC45673.1 - 0.036 14.5 10.0 0.074 13.5 4.0 2.6 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DUF2826 PF11442.8 EWC45673.1 - 0.17 11.7 0.1 0.26 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) Smg4_UPF3 PF03467.15 EWC45674.1 - 6.9e-45 153.2 0.0 6.9e-45 153.2 0.0 2.7 3 0 0 3 3 3 1 Smg-4/UPF3 family DUF3915 PF13054.6 EWC45674.1 - 0.0014 18.6 4.4 0.003 17.5 4.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Med19 PF10278.9 EWC45674.1 - 0.75 9.7 10.4 0.21 11.5 5.8 2.1 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Putative_PNPOx PF01243.20 EWC45675.1 - 0.0066 16.6 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Metallophos PF00149.28 EWC45676.1 - 1.1e-36 127.2 0.1 1.7e-36 126.7 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EWC45676.1 - 0.0089 15.7 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Zn_clus PF00172.18 EWC45677.1 - 0.00045 20.3 7.0 0.00071 19.7 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1412 PF07203.11 EWC45677.1 - 0.1 12.8 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1412) Cript PF10235.9 EWC45677.1 - 4.5 7.9 8.4 0.57 10.8 3.6 2.0 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT Snf7 PF03357.21 EWC45678.1 - 1.7e-20 73.4 2.0 2.6e-20 72.7 2.0 1.2 1 0 0 1 1 1 1 Snf7 MerR-DNA-bind PF09278.11 EWC45678.1 - 0.0092 16.5 5.6 0.57 10.7 0.5 3.8 4 0 0 4 4 4 2 MerR, DNA binding CS PF04969.16 EWC45679.1 - 0.00067 20.6 0.0 0.0013 19.7 0.0 1.6 1 0 0 1 1 1 1 CS domain BssC_TutF PF08201.11 EWC45679.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 BssC/TutF protein M_domain PF12938.7 EWC45679.1 - 0.31 10.8 1.0 0.41 10.4 1.0 1.1 1 0 0 1 1 1 0 M domain of GW182 Pirin PF02678.16 EWC45680.1 - 1.1e-28 99.4 0.1 2.8e-28 98.0 0.0 1.7 2 0 0 2 2 2 1 Pirin Cupin_2 PF07883.11 EWC45680.1 - 3e-06 26.8 0.9 0.0005 19.7 0.2 2.3 2 0 0 2 2 2 2 Cupin domain Pirin_C_2 PF17954.1 EWC45680.1 - 0.041 14.1 0.1 0.9 9.8 0.0 2.5 2 1 0 2 2 2 0 Quercetinase C-terminal cupin domain Cupin_3 PF05899.12 EWC45680.1 - 0.094 12.4 0.3 3.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF861) adh_short PF00106.25 EWC45682.1 - 9.1e-21 74.2 0.0 1.2e-15 57.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC45682.1 - 4.3e-11 42.8 0.0 6.1e-10 39.0 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1972 PF09314.11 EWC45682.1 - 0.0055 16.3 0.0 0.34 10.5 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1972) Polysacc_synt_2 PF02719.15 EWC45682.1 - 0.0081 15.3 0.0 0.049 12.8 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EWC45682.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 KR domain ANAPC4_WD40 PF12894.7 EWC45684.1 - 0.034 14.5 0.1 4.5 7.6 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EWC45684.1 - 0.057 13.0 2.8 3.4 7.2 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain WD40 PF00400.32 EWC45684.1 - 0.12 13.3 1.0 30 5.7 0.4 3.2 2 0 0 2 2 2 0 WD domain, G-beta repeat Ferric_reduct PF01794.19 EWC45685.1 - 1.4e-21 76.9 14.7 1.4e-21 76.9 14.7 2.7 3 0 0 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EWC45685.1 - 2.7e-06 27.6 0.1 0.036 14.2 0.0 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EWC45685.1 - 4e-06 26.9 0.0 0.00036 20.6 0.0 2.5 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EWC45685.1 - 0.092 13.4 0.1 0.89 10.2 0.0 2.4 1 1 1 2 2 2 0 Oxidoreductase NAD-binding domain DUF4405 PF14358.6 EWC45685.1 - 6.1 7.5 14.6 1.2 9.7 2.8 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) Peptidase_C28 PF05408.11 EWC45686.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Foot-and-mouth virus L-proteinase Imm48 PF15574.6 EWC45686.1 - 0.13 12.1 0.0 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 48 PRMT5 PF05185.16 EWC45687.1 - 5.5e-66 221.7 0.0 1e-65 220.8 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_TIM PF17285.2 EWC45687.1 - 7.6e-60 202.3 0.0 1e-59 201.8 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5_C PF17286.2 EWC45687.1 - 2.1e-52 177.6 0.0 3.2e-52 177.0 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain DUF3653 PF12375.8 EWC45687.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Phage protein FOXP-CC PF16159.5 EWC45689.1 - 0.013 16.1 0.8 0.042 14.5 0.8 1.8 1 0 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 EWC45689.1 - 0.074 13.2 0.2 0.12 12.5 0.2 1.3 1 0 0 1 1 1 0 Aberrant zinc-finger Ribosomal_L26 PF16906.5 EWC45690.1 - 1.1e-38 131.6 3.0 1.3e-38 131.3 3.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EWC45690.1 - 2e-08 33.9 1.2 4.9e-08 32.6 1.2 1.7 1 0 0 1 1 1 1 KOW motif DUF4663 PF15668.5 EWC45690.1 - 0.081 12.0 0.2 0.095 11.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) Ribosomal_S19 PF00203.21 EWC45691.1 - 1.8e-25 88.6 0.0 2.2e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Mre11_DNA_bind PF04152.14 EWC45692.1 - 2e-54 184.5 1.0 5.4e-54 183.0 1.0 1.8 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EWC45692.1 - 9.8e-15 55.6 2.6 3.3e-14 53.9 1.1 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EWC45692.1 - 7.5e-06 26.2 0.0 6.9e-05 23.1 0.0 2.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PBP1_TM PF14812.6 EWC45692.1 - 0.51 10.7 19.9 0.2 12.0 5.3 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pns11_12 PF17464.2 EWC45693.1 - 0.19 11.4 0.1 0.31 10.7 0.1 1.2 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Peptidase_M43 PF05572.13 EWC45694.1 - 7.4e-14 51.9 0.3 1.2e-13 51.3 0.3 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A DUF4573 PF15140.6 EWC45694.1 - 0.0034 17.2 4.5 0.0054 16.5 4.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) Reprolysin_5 PF13688.6 EWC45694.1 - 0.0035 17.5 0.3 0.0059 16.8 0.3 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M7 PF02031.16 EWC45694.1 - 0.0038 17.4 0.2 0.009 16.1 0.1 1.7 2 0 0 2 2 2 1 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M10 PF00413.24 EWC45694.1 - 0.0066 16.3 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 EWC45694.1 - 0.0075 16.8 0.0 0.012 16.1 0.0 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EWC45694.1 - 0.0095 15.6 0.1 0.019 14.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Amelogenin PF02948.15 EWC45694.1 - 0.37 11.4 17.3 10 6.7 17.3 2.2 1 1 0 1 1 1 0 Amelogenin Glycos_transf_1 PF00534.20 EWC45695.1 - 3.7e-32 111.2 0.0 3.3e-30 104.9 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EWC45695.1 - 9.1e-15 55.3 0.0 2.3e-14 54.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EWC45695.1 - 1.5e-12 47.9 0.1 2.4e-12 47.2 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EWC45695.1 - 1.3e-05 25.5 0.1 0.00021 21.6 0.0 2.6 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EWC45695.1 - 0.0037 17.7 0.0 0.0086 16.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_5 PF16994.5 EWC45695.1 - 0.018 14.7 0.1 0.059 13.0 0.0 1.8 2 0 0 2 2 2 0 Glycosyl-transferase family 4 Zn_clus PF00172.18 EWC45697.1 - 1.8e-05 24.8 26.9 0.012 15.7 11.8 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl_transf_3 PF01757.22 EWC45699.1 - 7.2e-33 114.1 26.2 9.7e-32 110.4 26.2 2.5 1 1 0 1 1 1 1 Acyltransferase family Cuticle_2 PF08184.11 EWC45699.1 - 0.011 15.7 3.1 0.12 12.4 3.0 2.3 2 0 0 2 2 2 0 Cuticle protein 7 isoform family TerC PF03741.16 EWC45699.1 - 5.9 6.5 7.2 19 4.9 0.1 2.9 3 1 0 3 3 3 0 Integral membrane protein TerC family ADH_zinc_N PF00107.26 EWC45700.1 - 1.1e-09 38.4 1.0 1.3e-09 38.1 0.1 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EWC45700.1 - 7.2e-06 25.9 0.0 3.7e-05 23.5 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain TRF PF08558.10 EWC45701.1 - 6.8e-62 209.2 0.0 9.6e-62 208.7 0.0 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EWC45701.1 - 0.01 16.0 0.0 0.023 14.9 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Porin_3 PF01459.22 EWC45703.1 - 5.4e-61 206.4 4.9 6.3e-61 206.2 4.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin OMP_b-brl PF13505.6 EWC45703.1 - 0.014 15.6 6.7 0.045 13.9 6.8 1.9 1 1 0 1 1 1 0 Outer membrane protein beta-barrel domain OpcA PF07239.11 EWC45703.1 - 0.026 14.2 0.1 0.056 13.1 0.1 1.6 1 0 0 1 1 1 0 Outer membrane protein OpcA Lyase_1 PF00206.20 EWC45705.1 - 1.1e-19 71.0 0.0 1.7e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EWC45705.1 - 4.1e-15 56.1 0.2 1.3e-14 54.5 0.0 2.0 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus Mpp10 PF04006.12 EWC45706.1 - 5.7e-85 286.0 0.0 1.5e-84 284.7 0.0 1.5 1 1 0 1 1 1 1 Mpp10 protein Ribosom_S12_S23 PF00164.25 EWC45707.1 - 5.1e-51 171.1 0.6 6.3e-51 170.8 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Pex19 PF04614.12 EWC45708.1 - 1e-69 235.0 6.6 1e-69 235.0 6.6 1.9 2 0 0 2 2 2 1 Pex19 protein family ATG_C PF09333.11 EWC45708.1 - 0.013 15.9 0.0 0.044 14.1 0.0 1.9 1 1 1 2 2 2 0 Autophagy-related protein C terminal domain LXG PF04740.12 EWC45708.1 - 0.02 14.6 0.3 0.071 12.8 0.0 2.0 2 0 0 2 2 2 0 LXG domain of WXG superfamily RXT2_N PF08595.11 EWC45708.1 - 0.037 14.1 2.1 0.08 13.0 2.1 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal T2SSF PF00482.23 EWC45708.1 - 0.34 10.9 1.1 2.1 8.3 0.3 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F cwf18 PF08315.12 EWC45709.1 - 2.9e-35 121.9 5.5 2.9e-35 121.9 5.5 1.5 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor ABC1 PF03109.16 EWC45710.1 - 3.2e-11 43.4 0.1 1.1e-06 28.8 0.1 2.5 1 1 1 2 2 2 2 ABC1 family RIO1 PF01163.22 EWC45710.1 - 0.085 12.5 0.0 0.27 10.8 0.0 1.7 2 0 0 2 2 2 0 RIO1 family DUF913 PF06025.12 EWC45711.1 - 0.0011 18.0 1.3 0.5 9.3 0.0 2.6 2 0 0 2 2 2 2 Domain of Unknown Function (DUF913) Ric8 PF10165.9 EWC45711.1 - 0.0091 15.1 0.7 0.016 14.2 0.7 1.3 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Med15_fungi PF05397.12 EWC45711.1 - 0.046 14.0 1.7 0.081 13.2 0.4 2.0 1 1 1 2 2 2 0 Mediator complex subunit 15 TIMELESS PF04821.14 EWC45711.1 - 0.068 12.4 3.4 0.38 10.0 3.4 2.0 1 1 0 1 1 1 0 Timeless protein GerD PF17898.1 EWC45711.1 - 0.11 12.5 2.0 0.27 11.2 2.0 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain RICTOR_M PF14666.6 EWC45711.1 - 0.14 11.9 0.8 0.84 9.4 0.2 2.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain PPI_Ypi1 PF07491.11 EWC45712.1 - 1.1e-11 44.4 0.1 1.6e-11 43.8 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor MRP-S25 PF13741.6 EWC45713.1 - 1.8e-77 260.0 3.6 3.8e-76 255.7 3.6 2.0 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EWC45713.1 - 1.5e-05 25.3 1.2 0.00011 22.5 1.2 2.3 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S23 TFIID-18kDa PF02269.16 EWC45714.1 - 2.9e-31 107.3 0.2 3.4e-31 107.1 0.2 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-S PF15630.6 EWC45714.1 - 1.9e-05 25.0 0.0 3.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.13 EWC45714.1 - 2.5e-05 24.2 0.0 3.8e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 EWC45714.1 - 4.8e-05 23.7 0.0 6.1e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EWC45714.1 - 0.00018 21.7 1.7 0.00022 21.5 0.6 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 EWC45714.1 - 0.0006 19.9 0.7 0.00095 19.3 0.1 1.5 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) CENP-T_C PF15511.6 EWC45714.1 - 0.001 19.2 0.1 0.0012 18.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 EWC45714.1 - 0.002 18.2 0.1 0.0037 17.3 0.1 1.4 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit UTP25 PF06862.12 EWC45715.1 - 3.1e-164 547.2 0.0 3.8e-164 547.0 0.0 1.0 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Ufd2P_core PF10408.9 EWC45716.1 - 6.9e-212 705.4 0.2 1.1e-211 704.8 0.2 1.3 2 0 0 2 2 2 1 Ubiquitin elongating factor core U-box PF04564.15 EWC45716.1 - 1.3e-24 86.2 0.7 3.6e-24 84.7 0.7 1.9 1 0 0 1 1 1 1 U-box domain NLE PF08154.12 EWC45716.1 - 0.0092 16.5 1.7 1.8 9.2 0.0 3.6 3 0 0 3 3 3 1 NLE (NUC135) domain Sod_Fe_N PF00081.22 EWC45716.1 - 0.13 12.8 1.2 2.2 8.8 0.3 3.0 2 1 1 3 3 3 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Ras PF00071.22 EWC45717.1 - 2.7e-56 189.6 0.0 3.1e-56 189.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC45717.1 - 4.1e-22 78.7 0.0 6.5e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC45717.1 - 9.1e-07 28.5 0.0 1.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EWC45717.1 - 0.0021 17.5 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 EWC45717.1 - 0.015 14.5 0.1 0.2 10.8 0.0 2.0 1 1 0 2 2 2 0 NB-ARC domain PduV-EutP PF10662.9 EWC45717.1 - 0.17 11.7 0.0 22 4.8 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EWC45717.1 - 0.18 11.1 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Rtt106 PF08512.12 EWC45718.1 - 4.4e-26 91.1 0.0 8.4e-26 90.2 0.0 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_18 PF18469.1 EWC45718.1 - 0.00039 20.4 0.0 0.0015 18.5 0.0 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain Drc1-Sld2 PF11719.8 EWC45718.1 - 0.55 9.7 12.1 0.044 13.3 6.1 1.9 2 0 0 2 2 2 0 DNA replication and checkpoint protein BUD22 PF09073.10 EWC45718.1 - 0.87 8.9 13.8 1.2 8.4 13.8 1.1 1 0 0 1 1 1 0 BUD22 IFT57 PF10498.9 EWC45718.1 - 1.2 8.1 4.7 1.6 7.6 4.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 NOA36 PF06524.12 EWC45718.1 - 2.7 7.2 8.0 3.7 6.8 8.0 1.3 1 0 0 1 1 1 0 NOA36 protein Asp PF00026.23 EWC45719.1 - 1.9e-65 221.3 0.2 2.4e-65 221.0 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EWC45719.1 - 7.9e-16 58.8 1.8 5.2e-09 36.6 0.5 2.9 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EWC45719.1 - 1.4e-07 32.0 0.2 0.002 18.7 0.1 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EWC45719.1 - 1.5e-05 25.4 0.0 0.045 14.3 0.0 2.9 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease Apt1 PF10351.9 EWC45721.1 - 0.34 9.7 4.8 0.29 10.0 4.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain KH_1 PF00013.29 EWC45722.1 - 4e-08 33.0 0.1 5.4e-07 29.3 0.0 2.2 2 0 0 2 2 2 1 KH domain UPF0181 PF03701.14 EWC45722.1 - 0.15 11.7 0.1 0.15 11.7 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) DUF2277 PF10041.9 EWC45722.1 - 0.16 12.3 0.0 0.41 11.0 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) SelP_N PF04592.14 EWC45722.1 - 0.29 10.5 5.1 0.45 9.9 5.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Totivirus_coat PF05518.11 EWC45722.1 - 7.3 4.5 11.2 11 3.9 11.2 1.3 1 0 0 1 1 1 0 Totivirus coat protein ALS_ss_C PF10369.9 EWC45723.1 - 8.1e-16 58.0 0.1 1.2e-14 54.2 0.0 2.2 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 EWC45723.1 - 3.1e-13 49.3 0.1 5.1e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EWC45723.1 - 1.8e-07 30.9 0.0 3.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 ACT domain DUF1949 PF09186.11 EWC45723.1 - 0.016 15.1 0.0 3.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1949) ACT_6 PF13740.6 EWC45723.1 - 0.053 13.5 0.1 11 6.1 0.0 2.6 2 0 0 2 2 2 0 ACT domain DUF3712 PF12505.8 EWC45724.1 - 0.003 17.8 0.1 0.0089 16.3 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3712) OTCace PF00185.24 EWC45725.1 - 8.8e-46 155.8 0.0 1.3e-45 155.3 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EWC45725.1 - 6.8e-44 149.5 0.2 9.6e-44 149.0 0.2 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Bep_C_terminal PF17841.1 EWC45725.1 - 0.014 15.6 0.7 0.95 9.7 0.2 2.6 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) Glyco_hydro_101 PF12905.7 EWC45725.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase Ribosomal_L17 PF01196.19 EWC45726.1 - 3.1e-31 108.1 0.1 4.9e-31 107.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Mrpl_C PF18502.1 EWC45726.1 - 0.002 18.4 0.1 0.11 12.7 0.0 2.1 2 0 0 2 2 2 1 54S ribosomal protein L8 C-terminal domain Molybdopterin_N PF18364.1 EWC45726.1 - 0.088 12.8 0.0 0.25 11.4 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin oxidoreductase N-terminal domain Ribosomal_L32p PF01783.23 EWC45727.1 - 2.6e-15 56.4 2.4 3.3e-15 56.1 2.4 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-TFIIB PF13453.6 EWC45727.1 - 0.026 13.9 0.3 2 7.8 0.1 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger Septin PF00735.18 EWC45728.1 - 9.6e-113 376.1 0.3 1.1e-112 375.9 0.3 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EWC45728.1 - 7.2e-08 32.5 0.0 1.3e-07 31.6 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EWC45728.1 - 5.1e-06 26.0 0.0 8.6e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EWC45728.1 - 3.3e-05 23.9 0.3 0.00026 20.9 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EWC45728.1 - 0.00022 20.8 0.7 0.016 14.7 0.1 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EWC45728.1 - 0.0005 20.2 0.3 1.5 8.9 0.0 2.5 1 1 0 2 2 2 2 Dynamin family AAA_16 PF13191.6 EWC45728.1 - 0.001 19.5 0.1 0.0073 16.7 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EWC45728.1 - 0.0057 15.9 0.1 0.01 15.0 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_7 PF12775.7 EWC45728.1 - 0.0059 16.1 0.0 0.034 13.7 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EWC45728.1 - 0.009 16.3 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EWC45728.1 - 0.015 15.8 0.2 0.025 15.1 0.2 1.6 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.20 EWC45728.1 - 0.036 13.2 0.5 0.14 11.2 0.5 1.9 1 1 0 1 1 1 0 G-protein alpha subunit Gtr1_RagA PF04670.12 EWC45728.1 - 0.067 12.5 0.1 0.65 9.3 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.18 EWC45728.1 - 0.075 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.6 EWC45728.1 - 0.1 13.1 0.2 0.2 12.2 0.2 1.5 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EWC45728.1 - 0.11 11.6 0.0 0.27 10.3 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 EWC45728.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EWC45728.1 - 0.14 12.0 0.1 0.39 10.5 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Guanylate_kin PF00625.21 EWC45729.1 - 1.9e-57 193.9 0.0 2.3e-57 193.6 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EWC45729.1 - 4.2e-07 30.5 0.1 7.9e-07 29.6 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EWC45729.1 - 1.3e-05 25.4 0.0 3.6e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EWC45729.1 - 9e-05 22.8 0.0 0.00043 20.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EWC45729.1 - 0.0001 22.8 0.1 0.0005 20.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EWC45729.1 - 0.00017 22.1 0.0 0.0002 21.9 0.0 1.5 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EWC45729.1 - 0.0003 20.7 0.0 0.00056 19.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_28 PF13521.6 EWC45729.1 - 0.002 18.4 0.0 0.0042 17.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EWC45729.1 - 0.0026 17.4 0.1 0.0083 15.8 0.2 1.7 2 0 0 2 2 1 1 P-loop containing region of AAA domain CPT PF07931.12 EWC45729.1 - 0.0051 16.7 0.0 0.011 15.6 0.0 1.5 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein cobW PF02492.19 EWC45729.1 - 0.0053 16.4 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EWC45729.1 - 0.0065 16.2 0.0 0.0086 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EWC45729.1 - 0.0073 16.2 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_24 PF13479.6 EWC45729.1 - 0.011 15.5 1.0 0.2 11.3 0.1 2.7 1 1 1 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EWC45729.1 - 0.013 15.6 0.0 0.047 13.8 0.0 2.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA PF00004.29 EWC45729.1 - 0.016 15.7 0.1 0.61 10.5 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EWC45729.1 - 0.016 15.6 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EWC45729.1 - 0.017 15.2 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 EWC45729.1 - 0.021 13.6 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein TniB PF05621.11 EWC45729.1 - 0.022 14.2 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NB-ARC PF00931.22 EWC45729.1 - 0.024 13.9 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 EWC45729.1 - 0.026 14.5 0.0 0.09 12.7 0.0 1.8 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 EWC45729.1 - 0.03 14.3 0.0 0.059 13.4 0.0 1.6 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EWC45729.1 - 0.035 14.6 0.4 0.042 14.3 0.4 1.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EWC45729.1 - 0.044 13.7 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Phage_Cox PF10743.9 EWC45729.1 - 0.056 13.5 0.1 7.1 6.8 0.0 2.7 2 1 1 3 3 3 0 Regulatory phage protein cox AAA_17 PF13207.6 EWC45729.1 - 0.071 13.5 0.1 0.12 12.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EWC45729.1 - 0.08 12.0 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.14 EWC45729.1 - 0.081 12.9 0.0 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Roc PF08477.13 EWC45729.1 - 0.15 12.3 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EWC45729.1 - 0.21 11.1 0.0 0.38 10.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad52_Rad22 PF04098.15 EWC45730.1 - 3.4e-46 157.0 0.0 6.7e-46 156.0 0.0 1.5 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein M-factor PF03855.13 EWC45730.1 - 0.032 14.4 0.2 0.077 13.2 0.2 1.6 1 0 0 1 1 1 0 M-factor rRNA_proc-arch PF13234.6 EWC45731.1 - 7.5e-93 311.4 0.0 1.4e-92 310.5 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 EWC45731.1 - 6e-53 178.9 2.9 1.8e-52 177.3 2.9 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EWC45731.1 - 9.5e-20 71.1 0.1 3.3e-19 69.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC45731.1 - 2.5e-06 27.8 0.0 1.2e-05 25.6 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC45731.1 - 7.8e-05 22.7 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 EWC45731.1 - 0.047 13.6 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 EWC45731.1 - 0.067 12.2 0.0 0.24 10.4 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein COX7C PF02935.16 EWC45732.1 - 6.2e-22 77.6 2.8 8.3e-22 77.2 2.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc IKI3 PF04762.12 EWC45733.1 - 7.7e-273 907.8 0.0 9.8e-273 907.5 0.0 1.0 1 0 0 1 1 1 1 IKI3 family DUF3017 PF11222.8 EWC45734.1 - 1.6 9.1 7.6 8.2 6.8 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3017) MDD_C PF18376.1 EWC45735.1 - 2.4e-63 213.3 0.0 3.5e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EWC45735.1 - 4.3e-08 33.3 0.6 4.3e-08 33.3 0.6 2.4 2 0 0 2 2 2 1 GHMP kinases N terminal domain Dicer_dimer PF03368.14 EWC45735.1 - 0.028 14.6 0.1 3.4 7.9 0.0 2.6 2 0 0 2 2 2 0 Dicer dimerisation domain Cyto_heme_lyase PF01265.17 EWC45736.1 - 1.7e-38 132.9 15.0 1.5e-36 126.5 15.0 3.3 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase Ndc1_Nup PF09531.10 EWC45737.1 - 5e-130 435.1 1.1 5.7e-130 434.9 1.1 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup MOZART1 PF12554.8 EWC45738.1 - 5.3e-26 90.1 1.3 6.2e-26 89.9 1.3 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Rrn6 PF10214.9 EWC45739.1 - 1.7e-14 53.4 4.1 1.9e-14 53.2 4.1 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor DUF1509 PF07420.11 EWC45739.1 - 0.012 14.6 1.3 0.018 14.0 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Rrn6 PF10214.9 EWC45740.1 - 4.4e-05 22.2 0.0 6.4e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor CRM1_C PF08767.11 EWC45741.1 - 6.6e-133 442.8 1.6 6.2e-132 439.6 0.2 2.7 2 0 0 2 2 2 1 CRM1 C terminal Xpo1 PF08389.12 EWC45741.1 - 5.1e-40 137.0 8.2 1.2e-38 132.6 5.3 4.0 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EWC45741.1 - 2.1e-32 110.6 4.6 3.1e-32 110.0 2.4 2.5 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EWC45741.1 - 5.3e-30 103.3 2.3 1.3e-29 102.0 0.9 2.5 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EWC45741.1 - 3.7e-19 67.9 2.7 8.2e-19 66.8 2.7 1.6 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EWC45741.1 - 2.4e-11 43.4 0.5 8.5e-11 41.6 0.1 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3385 PF11865.8 EWC45741.1 - 0.0093 15.9 5.0 0.32 10.9 0.0 4.2 5 1 0 5 5 5 1 Domain of unknown function (DUF3385) Sid-5 PF17204.3 EWC45741.1 - 0.025 14.8 0.3 3 8.1 0.0 3.1 3 0 0 3 3 3 0 Sid-5 family Ank_2 PF12796.7 EWC45743.1 - 7.4e-29 100.2 4.8 4.9e-09 36.7 0.1 3.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC45743.1 - 5.1e-23 81.1 6.5 1.6e-10 41.3 0.1 4.7 3 1 1 5 5 4 4 Ankyrin repeats (many copies) SPX PF03105.19 EWC45743.1 - 1.3e-17 64.8 11.8 7.6e-09 36.0 0.7 5.0 3 1 2 5 5 4 3 SPX domain Ank_3 PF13606.6 EWC45743.1 - 1.3e-14 52.8 7.7 0.015 15.8 0.1 6.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EWC45743.1 - 1.7e-13 50.5 8.9 0.0015 18.8 0.0 6.5 1 1 6 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EWC45743.1 - 8.3e-09 35.5 16.2 0.041 14.3 0.3 6.7 6 1 1 7 7 7 4 Ankyrin repeat GDPD PF03009.17 EWC45743.1 - 3.5e-08 33.5 0.0 7.4e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family TMEM154 PF15102.6 EWC45743.1 - 0.00018 21.4 0.2 0.00047 20.1 0.2 1.7 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.10 EWC45743.1 - 0.0035 16.7 0.9 0.0073 15.7 0.9 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF2207 PF09972.9 EWC45743.1 - 0.063 12.0 0.2 0.49 9.1 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4448 PF14610.6 EWC45743.1 - 0.076 12.8 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Coa1 PF08695.10 EWC45744.1 - 9.4e-34 115.7 0.0 1.2e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 zinc_ribbon_6 PF14599.6 EWC45745.1 - 1.4e-24 85.8 4.7 2.2e-24 85.2 4.7 1.3 1 0 0 1 1 1 1 Zinc-ribbon zf-CHY PF05495.12 EWC45746.1 - 1.6e-11 44.5 4.8 2.8e-11 43.8 4.8 1.3 1 0 0 1 1 1 1 CHY zinc finger Complex1_LYR PF05347.15 EWC45747.1 - 0.03 14.4 0.2 0.065 13.3 0.2 1.5 1 0 0 1 1 1 0 Complex 1 protein (LYR family) DPBB_1 PF03330.18 EWC45748.1 - 2.7e-07 30.8 0.0 5.3e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EWC45748.1 - 0.0034 17.2 0.0 0.0047 16.8 0.0 1.2 1 0 0 1 1 1 1 Barwin family AAA PF00004.29 EWC45749.1 - 1.2e-93 310.4 0.0 1.6e-47 161.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC45749.1 - 6.7e-18 64.2 0.0 1.5e-07 31.1 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EWC45749.1 - 1e-14 54.6 0.0 2.1e-06 27.6 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EWC45749.1 - 1.4e-14 54.8 0.2 3.2e-05 24.4 0.0 5.1 3 2 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EWC45749.1 - 1.2e-12 48.1 0.0 6.4e-05 23.0 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EWC45749.1 - 8.4e-12 45.5 0.2 0.0013 19.0 0.0 4.2 2 2 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EWC45749.1 - 8.9e-12 45.4 0.0 0.00024 21.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 EWC45749.1 - 7.7e-10 39.1 0.0 0.00011 22.5 0.0 2.7 2 1 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 EWC45749.1 - 1.1e-09 38.5 0.0 0.00081 19.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EWC45749.1 - 1.3e-09 38.2 0.0 0.0018 18.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EWC45749.1 - 5.3e-09 36.5 0.0 0.00027 21.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EWC45749.1 - 6.4e-08 32.2 0.1 0.002 17.4 0.0 2.6 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 EWC45749.1 - 7.3e-08 33.0 0.0 0.018 15.6 0.0 2.7 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EWC45749.1 - 1.5e-07 31.4 0.0 0.022 14.5 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EWC45749.1 - 1.5e-07 31.0 0.8 0.016 14.6 0.2 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EWC45749.1 - 5.3e-07 29.7 0.4 0.033 14.1 0.0 3.5 3 1 0 4 4 3 2 NACHT domain AAA_3 PF07726.11 EWC45749.1 - 6.6e-07 29.3 0.0 0.0029 17.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EWC45749.1 - 2.5e-06 27.5 0.0 0.049 13.6 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EWC45749.1 - 7e-06 25.5 0.2 0.044 13.1 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin Viral_helicase1 PF01443.18 EWC45749.1 - 7.2e-06 25.9 0.0 0.032 14.0 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 EWC45749.1 - 8e-06 25.6 8.6 0.28 10.7 0.0 4.8 4 1 1 5 5 5 2 AAA domain Rad17 PF03215.15 EWC45749.1 - 1.7e-05 24.9 0.0 0.21 11.5 0.0 2.6 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_17 PF13207.6 EWC45749.1 - 4.1e-05 24.0 0.0 0.37 11.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EWC45749.1 - 4.2e-05 24.1 0.0 0.39 11.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter NB-ARC PF00931.22 EWC45749.1 - 4.4e-05 22.8 0.0 0.28 10.3 0.0 2.6 3 0 0 3 3 2 2 NB-ARC domain Sigma54_activat PF00158.26 EWC45749.1 - 4.5e-05 23.2 0.0 0.29 10.8 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain ATPase_2 PF01637.18 EWC45749.1 - 5.5e-05 23.2 0.0 0.12 12.3 0.0 3.6 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea Cytidylate_kin2 PF13189.6 EWC45749.1 - 6.3e-05 23.2 0.0 0.029 14.5 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_24 PF13479.6 EWC45749.1 - 0.00015 21.6 0.0 0.2 11.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EWC45749.1 - 0.00017 21.0 0.5 0.55 9.5 0.0 3.1 3 0 0 3 3 3 2 KaiC AAA_7 PF12775.7 EWC45749.1 - 0.00022 20.8 0.0 0.86 9.1 0.0 3.0 2 2 0 2 2 2 2 P-loop containing dynein motor region Parvo_NS1 PF01057.17 EWC45749.1 - 0.00054 19.1 0.1 0.73 8.9 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ATP-synt_ab PF00006.25 EWC45749.1 - 0.00084 19.1 0.0 0.68 9.5 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain TniB PF05621.11 EWC45749.1 - 0.00085 18.8 0.0 2.8 7.3 0.0 3.8 2 2 2 4 4 4 1 Bacterial TniB protein PhoH PF02562.16 EWC45749.1 - 0.0018 17.7 0.5 2.9 7.3 0.0 3.0 3 0 0 3 3 2 2 PhoH-like protein Sigma54_activ_2 PF14532.6 EWC45749.1 - 0.0024 18.0 0.0 2.3 8.3 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Bac_DnaA PF00308.18 EWC45749.1 - 0.0027 17.6 0.0 0.27 11.0 0.0 2.6 3 0 0 3 3 2 1 Bacterial dnaA protein SKI PF01202.22 EWC45749.1 - 0.0065 16.6 0.0 6 7.0 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase AAA_11 PF13086.6 EWC45749.1 - 0.0079 16.0 1.2 3.5 7.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain Vps4_C PF09336.10 EWC45749.1 - 0.008 16.2 0.6 2.4 8.2 0.1 3.4 3 1 0 3 3 2 1 Vps4 C terminal oligomerisation domain DUF815 PF05673.13 EWC45749.1 - 0.0085 15.3 0.0 0.13 11.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) CPT PF07931.12 EWC45749.1 - 0.0092 15.8 0.1 1.6 8.5 0.0 3.0 3 0 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 EWC45749.1 - 0.014 15.7 0.8 5.8 7.2 0.2 2.7 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EWC45749.1 - 0.035 14.0 0.1 7.6 6.4 0.0 3.1 4 0 0 4 4 2 0 NTPase PduV-EutP PF10662.9 EWC45749.1 - 0.039 13.7 0.0 7.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF2075 PF09848.9 EWC45749.1 - 0.041 13.1 0.0 8.7 5.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Hydin_ADK PF17213.3 EWC45749.1 - 0.049 13.9 3.1 1.6 9.0 0.0 3.1 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain AAA_30 PF13604.6 EWC45749.1 - 0.06 13.1 0.0 8.8 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EWC45749.1 - 0.1 11.8 0.0 1.3 8.2 0.0 2.5 3 1 0 3 3 3 0 KAP family P-loop domain AAA_23 PF13476.6 EWC45749.1 - 0.13 12.7 0.0 4.5 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain IPT PF01745.16 EWC45749.1 - 0.14 11.5 0.0 6.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase MCM PF00493.23 EWC45749.1 - 0.16 11.0 0.0 7.3 5.6 0.0 2.9 3 0 0 3 3 3 0 MCM P-loop domain T2SSE PF00437.20 EWC45749.1 - 0.17 10.9 0.0 13 4.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein FeoB_N PF02421.18 EWC45749.1 - 0.26 10.8 0.6 10 5.6 0.0 2.6 3 0 0 3 3 2 0 Ferrous iron transport protein B Snf7 PF03357.21 EWC45750.1 - 1.1e-31 109.8 14.9 1.1e-31 109.8 14.9 1.4 2 0 0 2 2 2 1 Snf7 Selenoprotein_S PF06936.11 EWC45750.1 - 9.3 6.0 17.0 2.2 8.0 8.5 2.4 1 1 1 2 2 2 0 Selenoprotein S (SelS) Mito_carr PF00153.27 EWC45751.1 - 9.9e-29 99.1 1.6 1.6e-13 50.4 0.1 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein HECT PF00632.25 EWC45753.1 - 2.1e-96 323.1 0.0 2.9e-96 322.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EWC45753.1 - 2e-34 117.3 23.2 2.9e-12 46.4 4.2 4.1 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EWC45753.1 - 4.4e-20 71.9 0.0 1.6e-19 70.1 0.0 2.0 1 0 0 1 1 1 1 C2 domain RRM_1 PF00076.22 EWC45754.1 - 4.3e-06 26.5 0.0 7.3e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OmpH PF03938.14 EWC45754.1 - 0.0084 16.4 0.4 0.0092 16.3 0.4 1.3 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) YabA PF06156.13 EWC45754.1 - 0.01 16.5 0.6 0.012 16.2 0.6 1.2 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 EWC45754.1 - 0.011 16.2 5.7 0.018 15.5 5.7 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF724 PF05266.14 EWC45754.1 - 0.03 14.1 4.3 0.041 13.7 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DivIC PF04977.15 EWC45754.1 - 0.066 13.0 5.5 0.095 12.5 5.5 1.2 1 0 0 1 1 1 0 Septum formation initiator V_ATPase_I PF01496.19 EWC45754.1 - 0.092 10.6 0.2 0.087 10.7 0.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MMPL PF03176.15 EWC45754.1 - 0.24 10.3 0.5 0.27 10.1 0.5 1.0 1 0 0 1 1 1 0 MMPL family DUF3450 PF11932.8 EWC45754.1 - 0.28 10.4 3.8 0.37 10.1 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) bZIP_1 PF00170.21 EWC45754.1 - 0.49 10.5 6.1 0.73 10.0 6.1 1.2 1 0 0 1 1 1 0 bZIP transcription factor PIN_5 PF08745.11 EWC45755.1 - 6 6.2 7.3 1.8 7.9 2.4 2.6 3 1 0 3 3 3 0 PINc domain ribonuclease NIF PF03031.18 EWC45756.1 - 8.9e-12 45.0 0.0 1.5e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase AhpC-TSA PF00578.21 EWC45757.1 - 2.4e-25 88.9 0.0 3.8e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EWC45757.1 - 3.8e-17 62.3 0.0 6.9e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Redoxin Presenilin PF01080.17 EWC45757.1 - 3.4 6.3 9.8 5.7 5.6 9.8 1.5 1 0 0 1 1 1 0 Presenilin PRELI PF04707.14 EWC45758.1 - 4.7e-46 156.5 0.0 5.4e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family Spindle_Spc25 PF08234.12 EWC45759.1 - 1.8e-20 72.9 0.2 5.5e-20 71.3 0.1 1.9 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 ERM PF00769.19 EWC45759.1 - 0.0013 18.6 12.1 0.0014 18.5 12.1 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Atg14 PF10186.9 EWC45759.1 - 0.0013 17.9 7.1 0.0015 17.7 7.1 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0565 PF10561.9 EWC45759.1 - 0.0089 15.3 0.3 0.0098 15.1 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 Mei5 PF10376.9 EWC45759.1 - 0.094 12.6 11.8 0.14 12.0 11.8 1.2 1 0 0 1 1 1 0 Double-strand recombination repair protein HAUS-augmin3 PF14932.6 EWC45759.1 - 0.33 10.5 15.1 0.49 9.9 15.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Mito_fiss_reg PF05308.11 EWC45759.1 - 0.36 10.9 7.1 0.56 10.3 7.1 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator V_ATPase_I PF01496.19 EWC45759.1 - 0.41 8.5 5.6 0.47 8.3 5.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 EWC45759.1 - 0.76 10.3 22.4 1.8 9.1 22.4 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF641 PF04859.12 EWC45759.1 - 0.8 10.0 11.5 14 6.0 10.1 2.5 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) EPOP PF15223.6 EWC45759.1 - 0.82 9.0 8.3 1.1 8.5 8.3 1.1 1 0 0 1 1 1 0 Elongin BC and Polycomb repressive complex 2-associated protein LMBR1 PF04791.16 EWC45759.1 - 0.98 8.2 2.1 0.93 8.3 2.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 EWC45759.1 - 2.1 7.5 12.2 2.9 7.0 12.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 EWC45759.1 - 7.4 6.8 20.2 0.81 9.9 2.9 2.7 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Ribosomal_L3 PF00297.22 EWC45760.1 - 1.9e-13 50.2 0.4 2.4e-13 49.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 CUE PF02845.16 EWC45761.1 - 2.5e-11 43.0 0.0 4.1e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 CUE domain DUF5476 PF17570.2 EWC45761.1 - 2.3 8.7 5.5 0.52 10.7 0.3 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5476) Shugoshin_N PF07558.11 EWC45762.1 - 5.6e-07 29.3 5.4 1.3e-06 28.2 5.4 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EWC45762.1 - 1.1e-05 25.1 2.4 1.1e-05 25.1 2.4 3.8 3 0 0 3 3 3 1 Shugoshin C terminus KASH_CCD PF14662.6 EWC45762.1 - 0.015 15.1 3.4 0.78 9.5 1.7 2.7 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Mod_r PF07200.13 EWC45762.1 - 0.26 11.4 7.4 0.75 9.9 7.4 1.8 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF641 PF04859.12 EWC45762.1 - 0.38 11.1 3.6 1.1 9.6 1.9 2.4 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) MbeD_MobD PF04899.12 EWC45762.1 - 0.59 10.3 3.9 1.7 8.9 3.9 1.7 1 0 0 1 1 1 0 MbeD/MobD like DivIC PF04977.15 EWC45762.1 - 0.72 9.7 6.7 1.2 9.0 3.6 2.8 2 1 1 3 3 3 0 Septum formation initiator GIT_CC PF16559.5 EWC45762.1 - 1.1 9.2 4.5 1.4 8.8 2.9 2.1 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.12 EWC45762.1 - 1.2 9.2 2.9 8.9 6.4 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EWC45762.1 - 7.4 5.4 9.7 2.4 6.9 6.2 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein DASH_Dad2 PF08654.10 EWC45763.1 - 7e-24 84.1 3.9 2.5e-23 82.4 3.9 1.8 1 1 0 1 1 1 1 DASH complex subunit Dad2 SM-ATX PF14438.6 EWC45764.1 - 1.9e-18 66.3 0.0 3.5e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.13 EWC45764.1 - 4e-12 46.5 4.9 9.1e-07 29.3 0.1 3.0 2 1 1 3 3 3 2 LsmAD domain AIP3 PF03915.13 EWC45765.1 - 3.4e-140 467.7 5.1 4.8e-140 467.3 5.1 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 Wtap PF17098.5 EWC45765.1 - 0.013 15.4 0.3 0.046 13.6 0.3 1.9 1 0 0 1 1 1 0 WTAP/Mum2p family CorA PF01544.18 EWC45765.1 - 0.015 14.6 5.7 0.04 13.2 2.0 2.8 3 1 0 3 3 3 0 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 EWC45765.1 - 0.018 15.1 2.5 12 5.9 0.1 4.2 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Uds1 PF15456.6 EWC45765.1 - 0.03 14.5 0.3 0.03 14.5 0.3 3.2 4 1 0 4 4 2 0 Up-regulated During Septation DUF5082 PF16888.5 EWC45765.1 - 0.073 13.4 3.6 8.6 6.7 0.7 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) HALZ PF02183.18 EWC45765.1 - 0.09 13.0 8.2 0.16 12.2 0.6 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper TraF_2 PF13729.6 EWC45765.1 - 0.093 12.1 0.5 0.29 10.5 0.1 2.0 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein T2SSF PF00482.23 EWC45765.1 - 0.12 12.4 0.1 0.42 10.6 0.0 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Syntaxin-18_N PF10496.9 EWC45765.1 - 0.18 12.0 0.9 0.58 10.4 0.0 2.4 2 0 0 2 2 1 0 SNARE-complex protein Syntaxin-18 N-terminus Muted PF14942.6 EWC45765.1 - 0.5 10.7 6.8 0.96 9.8 0.7 3.5 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein JIP_LZII PF16471.5 EWC45765.1 - 0.55 10.4 0.0 0.55 10.4 0.0 3.5 4 0 0 4 4 3 0 JNK-interacting protein leucine zipper II DUF1204 PF06721.11 EWC45765.1 - 0.78 9.1 7.0 9.9 5.5 0.2 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1204) Transcrip_act PF04949.13 EWC45765.1 - 0.83 9.5 7.1 3.6 7.5 0.1 3.5 3 0 0 3 3 3 0 Transcriptional activator SOAR PF16533.5 EWC45765.1 - 1.1 9.3 7.1 2 8.4 0.3 4.2 4 1 1 5 5 5 0 STIM1 Orai1-activating region DUF948 PF06103.11 EWC45765.1 - 1.2 9.5 6.6 80 3.6 0.0 4.6 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 EWC45765.1 - 2.7 7.3 17.3 0.22 10.8 2.7 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 EWC45765.1 - 3.8 6.3 17.2 0.39 9.5 0.9 3.6 3 1 1 4 4 4 0 Spc7 kinetochore protein MIP-T3_C PF17749.1 EWC45765.1 - 5.1 7.0 8.2 0.72 9.8 0.3 3.1 2 1 1 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region Syntaxin_2 PF14523.6 EWC45765.1 - 6.6 7.2 0.0 6.6 7.2 0.0 5.0 4 1 1 5 5 5 0 Syntaxin-like protein Pkinase PF00069.25 EWC45766.1 - 3.3e-09 36.5 0.0 5.1e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EWC45766.1 - 7e-07 29.0 4.5 0.36 11.2 0.0 6.2 7 0 0 7 7 7 2 HEAT repeat Pkinase_Tyr PF07714.17 EWC45766.1 - 1.5e-06 27.7 0.0 2.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Cnd1 PF12717.7 EWC45766.1 - 2.6e-06 27.6 0.1 4.1e-05 23.7 0.0 2.3 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC45766.1 - 0.00066 20.0 0.4 0.013 15.9 0.2 3.2 2 1 0 3 3 3 1 HEAT repeats Kinase-like PF14531.6 EWC45766.1 - 0.024 14.0 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like HEAT_EZ PF13513.6 EWC45766.1 - 0.076 13.5 0.0 8.5 7.0 0.1 3.6 3 0 0 3 3 3 0 HEAT-like repeat Adaptin_N PF01602.20 EWC45766.1 - 0.16 10.5 0.0 0.68 8.4 0.0 1.8 1 1 1 2 2 2 0 Adaptin N terminal region MoaE PF02391.17 EWC45767.1 - 2.4e-33 114.8 0.0 3.1e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 MoaE protein DUF4363 PF14276.6 EWC45768.1 - 0.098 12.8 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Pkinase PF00069.25 EWC45769.1 - 1.8e-27 96.4 0.0 2.4e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45769.1 - 2.4e-14 53.2 0.0 3.4e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC45769.1 - 7.2e-07 28.3 0.0 1.3e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Nucleoporin_C PF03177.14 EWC45770.1 - 1.1e-105 354.6 4.9 1.6e-105 354.1 4.9 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EWC45770.1 - 1.6e-42 145.8 0.0 2.2e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like DUF2076 PF09849.9 EWC45770.1 - 0.45 10.5 3.5 0.89 9.5 3.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CIAPIN1 PF05093.13 EWC45771.1 - 1.4e-42 144.3 4.1 2.2e-42 143.7 4.1 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EWC45771.1 - 2.7e-31 108.6 0.1 5e-31 107.7 0.0 1.5 2 0 0 2 2 2 1 Fe-S cluster assembly protein DRE2 N-terminus HABP4_PAI-RBP1 PF04774.15 EWC45772.1 - 0.0013 19.5 1.7 0.0033 18.3 1.7 1.8 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family Arylesterase PF01731.20 EWC45773.1 - 6e-08 32.8 0.0 1.4e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Arylesterase Ribosomal_L7Ae PF01248.26 EWC45774.1 - 1.9e-23 82.0 4.6 8e-23 80.0 0.6 2.2 2 0 0 2 2 2 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family KAR PF15222.6 EWC45774.1 - 0.039 14.3 0.0 0.45 10.8 0.0 2.2 2 0 0 2 2 2 0 Kidney androgen-regulated YqaJ PF09588.10 EWC45774.1 - 0.088 13.0 0.1 0.13 12.4 0.1 1.4 1 1 0 1 1 1 0 YqaJ-like viral recombinase domain FGGY_C PF02782.16 EWC45775.1 - 1.4e-72 243.6 0.5 2.8e-72 242.6 0.5 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EWC45775.1 - 6.4e-59 199.5 0.0 9.1e-59 199.0 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EWC45775.1 - 0.034 13.7 0.0 0.26 10.7 0.0 2.4 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DUF1796 PF08795.10 EWC45775.1 - 0.094 12.7 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Peptidase_M41 PF01434.18 EWC45776.1 - 6.9e-63 212.0 1.5 6.9e-63 212.0 1.5 1.9 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 EWC45776.1 - 1.5e-40 138.7 0.0 3.6e-40 137.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC45776.1 - 2.1e-10 40.2 0.0 6e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 EWC45776.1 - 1.2e-05 24.7 0.1 5.2e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 EWC45776.1 - 6.3e-05 23.0 0.0 0.00026 21.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EWC45776.1 - 0.00014 22.3 5.7 0.00039 20.9 1.7 3.6 3 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EWC45776.1 - 0.00015 21.6 0.0 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EWC45776.1 - 0.00097 19.4 0.2 0.051 13.9 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EWC45776.1 - 0.0038 16.8 1.8 0.62 9.6 0.4 2.6 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 EWC45776.1 - 0.0059 16.8 0.0 0.015 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EWC45776.1 - 0.0075 16.0 0.0 0.02 14.6 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EWC45776.1 - 0.013 14.9 0.2 0.028 13.8 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EWC45776.1 - 0.023 14.8 0.0 0.085 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 EWC45776.1 - 0.028 14.1 0.0 0.71 9.6 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF3035 PF11233.8 EWC45776.1 - 0.055 13.8 3.1 0.06 13.6 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3035) AAA_28 PF13521.6 EWC45776.1 - 0.056 13.7 0.0 0.18 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EWC45776.1 - 0.057 14.0 0.0 0.22 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EWC45776.1 - 0.086 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EWC45776.1 - 0.095 12.2 0.1 0.39 10.2 0.1 2.1 2 1 0 2 2 1 0 P-loop containing dynein motor region RRM_1 PF00076.22 EWC45777.1 - 5.2e-80 263.3 3.1 6.8e-20 70.7 0.1 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EWC45777.1 - 3.3e-28 97.7 0.2 1.6e-27 95.5 0.2 2.2 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EWC45777.1 - 6.6e-10 38.7 0.4 0.0015 18.2 0.0 4.8 3 2 2 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EWC45777.1 - 0.00046 20.2 0.1 3.5 7.8 0.0 4.6 4 3 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EWC45777.1 - 0.00087 19.2 0.4 12 6.0 0.0 4.1 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EWC45777.1 - 0.0053 16.8 5.0 2.2 8.4 0.4 4.4 5 0 0 5 5 5 1 RNA binding motif RRM_occluded PF16842.5 EWC45777.1 - 0.021 14.7 0.2 2 8.4 0.0 3.3 4 0 0 4 4 4 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EWC45777.1 - 0.058 13.5 0.8 5.3 7.2 0.0 3.4 3 0 0 3 3 3 0 Limkain b1 Nefa_Nip30_N PF10187.9 EWC45777.1 - 0.066 13.6 0.4 0.066 13.6 0.4 2.8 3 0 0 3 3 3 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 OB_RNB PF08206.11 EWC45777.1 - 0.14 11.9 2.4 14 5.5 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain YflT PF11181.8 EWC45777.1 - 0.36 11.4 3.8 5.5 7.6 0.4 2.8 3 0 0 3 3 3 0 Heat induced stress protein YflT HECT PF00632.25 EWC45778.1 - 1.1e-80 271.5 0.0 1.7e-80 270.8 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EWC45778.1 - 0.0033 17.1 1.7 0.0033 17.1 1.7 2.2 2 0 0 2 2 2 1 IQ calmodulin-binding motif F-box-like PF12937.7 EWC45779.1 - 1.8e-06 27.7 1.0 3.4e-06 26.8 1.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC45779.1 - 2e-05 24.3 0.5 4.3e-05 23.3 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EWC45779.1 - 0.00023 21.0 0.1 0.00048 20.0 0.1 1.4 1 0 0 1 1 1 1 F-box WSC PF01822.19 EWC45780.1 - 7e-18 64.6 9.1 9.2e-18 64.2 9.1 1.2 1 0 0 1 1 1 1 WSC domain CDH-cyt PF16010.5 EWC45782.1 - 4.4e-46 156.9 0.1 4.4e-46 156.9 0.1 2.4 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_C PF05199.13 EWC45782.1 - 9.1e-27 94.3 0.0 2.3e-26 93.0 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EWC45782.1 - 1.3e-21 77.2 0.0 1.4e-20 73.8 0.0 2.6 1 1 0 1 1 1 1 GMC oxidoreductase CBM_1 PF00734.18 EWC45782.1 - 1.8e-11 43.8 9.8 5.2e-11 42.3 9.8 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain FAD_binding_2 PF00890.24 EWC45782.1 - 2.6e-09 36.7 0.1 1.7e-06 27.4 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EWC45782.1 - 4e-06 26.9 0.2 1.6e-05 25.1 0.2 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EWC45782.1 - 1.4e-05 24.8 0.1 0.017 14.7 0.0 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EWC45782.1 - 0.00037 19.3 0.7 0.00058 18.7 0.0 1.6 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EWC45782.1 - 0.00082 18.7 0.0 0.0017 17.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EWC45782.1 - 0.0033 16.8 0.3 0.032 13.6 0.1 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EWC45782.1 - 0.0034 16.7 0.1 0.007 15.7 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EWC45782.1 - 0.049 12.9 0.0 1.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.12 EWC45782.1 - 0.065 12.3 0.1 0.13 11.3 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Mucin PF01456.17 EWC45782.1 - 0.1 12.6 45.0 0.42 10.6 13.4 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein LPP20 PF02169.16 EWC45782.1 - 0.12 12.7 6.9 5 7.5 0.0 2.6 2 0 0 2 2 2 0 LPP20 lipoprotein Pyr_redox PF00070.27 EWC45782.1 - 0.14 12.7 0.0 1.3 9.6 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AJAP1_PANP_C PF15298.6 EWC45782.1 - 9.8 6.3 25.8 2.7 8.2 4.1 2.4 2 0 0 2 2 2 0 AJAP1/PANP C-terminus IDO PF01231.18 EWC45783.1 - 1.4e-38 132.8 0.0 1.8e-38 132.5 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Nucleos_tra2_C PF07662.13 EWC45784.1 - 4.9e-73 245.4 0.3 4.9e-73 245.4 0.3 2.4 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EWC45784.1 - 7.9e-24 84.1 3.8 7.9e-24 84.1 3.8 2.6 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus CN_hydrolase PF00795.22 EWC45785.1 - 6.1e-57 192.9 0.0 9.1e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Nucleopor_Nup85 PF07575.13 EWC45785.1 - 4.9e-25 88.1 0.0 2.6e-19 69.2 0.0 2.3 2 0 0 2 2 2 2 Nup85 Nucleoporin FliG_N PF14842.6 EWC45785.1 - 0.012 16.2 0.1 0.072 13.6 0.0 2.2 2 0 0 2 2 2 0 FliG N-terminal domain DUF5525 PF17663.1 EWC45785.1 - 0.044 11.9 2.7 0.064 11.3 2.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5525) ATG2_CAD PF13329.6 EWC45786.1 - 2.5e-37 128.0 0.8 1.6e-36 125.4 0.3 2.4 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EWC45786.1 - 1.9e-28 98.7 0.1 8.4e-28 96.6 0.1 2.3 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 EWC45786.1 - 3.3e-05 24.0 1.3 0.00046 20.3 0.0 3.2 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 EWC45786.1 - 0.019 14.7 0.0 0.053 13.3 0.0 1.7 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal SCP2 PF02036.17 EWC45788.1 - 1.4e-22 80.1 0.6 1.6e-22 79.8 0.6 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EWC45788.1 - 0.00013 22.2 0.1 0.00017 21.8 0.1 1.4 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal Nucleoporin_FG PF13634.6 EWC45789.1 - 5.5e-18 65.6 141.2 0.0049 17.7 18.7 8.9 3 3 6 9 9 9 7 Nucleoporin FG repeat region NUP50 PF08911.11 EWC45789.1 - 1e-14 55.0 1.0 1e-14 55.0 1.0 4.9 3 2 1 4 4 4 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.18 EWC45789.1 - 5e-09 36.5 0.2 7.9e-09 35.8 0.2 1.3 1 0 0 1 1 1 1 RanBP1 domain NOA36 PF06524.12 EWC45789.1 - 0.85 8.9 4.5 1.4 8.1 4.5 1.3 1 0 0 1 1 1 0 NOA36 protein Roughex PF06020.11 EWC45789.1 - 0.89 8.6 3.3 2.2 7.3 3.3 1.6 1 0 0 1 1 1 0 Drosophila roughex protein HATPase_c PF02518.26 EWC45791.1 - 1.3e-24 86.8 0.0 1.8e-23 83.2 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EWC45791.1 - 1.9e-24 86.0 0.1 3.6e-24 85.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EWC45791.1 - 8.3e-16 57.8 0.0 2.7e-15 56.2 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EWC45791.1 - 0.0048 17.2 0.0 0.025 14.9 0.0 2.3 1 1 0 1 1 1 1 HAMP domain Ribosomal_L33 PF00471.20 EWC45791.1 - 0.21 12.0 0.4 0.51 10.8 0.4 1.6 1 0 0 1 1 1 0 Ribosomal protein L33 ADH_zinc_N PF00107.26 EWC45792.1 - 6.2e-30 103.8 1.5 1.2e-29 102.9 0.5 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EWC45792.1 - 1e-14 55.7 0.0 1.7e-14 55.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EWC45792.1 - 3.7e-05 23.1 1.7 6.2e-05 22.4 1.2 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N PF08240.12 EWC45792.1 - 4.6e-05 23.2 0.0 0.00017 21.5 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain HupF_HypC PF01455.18 EWC45792.1 - 0.013 15.6 0.1 0.038 14.1 0.1 1.8 1 0 0 1 1 1 0 HupF/HypC family adh_short PF00106.25 EWC45792.1 - 0.14 11.6 0.7 0.22 10.9 0.7 1.3 1 0 0 1 1 1 0 short chain dehydrogenase EMP70 PF02990.16 EWC45793.1 - 1.1e-206 687.5 1.9 1.3e-206 687.3 1.9 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 ADIP PF11559.8 EWC45796.1 - 7.2e-34 117.1 9.6 2.5e-33 115.3 8.0 2.4 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.21 EWC45796.1 - 0.11 12.6 4.5 0.93 9.6 1.4 3.4 2 1 0 2 2 2 0 bZIP transcription factor Csm1_N PF18504.1 EWC45796.1 - 0.31 11.4 6.8 0.43 11.0 0.1 3.7 2 1 1 3 3 3 0 Csm1 N-terminal domain Viral_P18 PF04521.13 EWC45796.1 - 0.43 10.4 2.9 4.1 7.2 0.0 3.1 2 1 1 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein Rootletin PF15035.6 EWC45796.1 - 0.46 10.5 12.4 0.15 12.1 7.7 2.5 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF724 PF05266.14 EWC45796.1 - 0.47 10.2 8.9 1.6 8.5 3.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF5063 PF16702.5 EWC45796.1 - 0.49 10.8 3.0 1.3 9.4 2.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5063) YlqD PF11068.8 EWC45796.1 - 1.3 9.4 13.7 2.3 8.6 3.3 3.2 2 1 1 3 3 3 0 YlqD protein Arrestin_N PF00339.29 EWC45797.1 - 2.8e-14 53.4 0.0 8e-12 45.4 0.0 2.6 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Pyr_redox_2 PF07992.14 EWC45798.1 - 1.2e-48 165.8 1.3 1.7e-48 165.4 1.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EWC45798.1 - 4.2e-18 65.7 6.8 6.3e-15 55.5 0.3 3.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EWC45798.1 - 2.9e-14 52.7 0.0 7e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox_3 PF13738.6 EWC45798.1 - 2.6e-07 30.2 0.0 0.008 15.5 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EWC45798.1 - 6.3e-06 25.6 0.0 0.051 12.7 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EWC45798.1 - 1.6e-05 25.0 1.2 0.33 10.9 0.0 3.2 3 0 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 EWC45798.1 - 0.00015 21.5 3.5 0.023 14.3 0.0 3.6 2 2 1 4 4 4 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EWC45798.1 - 0.00062 19.2 0.0 0.29 10.3 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Reductase_C PF14759.6 EWC45798.1 - 0.00069 20.1 0.0 0.0019 18.7 0.0 1.8 1 0 0 1 1 1 1 Reductase C-terminal NAD_binding_7 PF13241.6 EWC45798.1 - 0.00074 19.9 0.3 0.82 10.1 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding Rieske_2 PF13806.6 EWC45798.1 - 0.0049 16.8 0.0 0.017 15.0 0.0 2.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF1188 PF06690.11 EWC45798.1 - 0.0056 16.3 0.1 0.01 15.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) TrkA_N PF02254.18 EWC45798.1 - 0.0085 16.3 0.3 1.1 9.5 0.1 2.5 2 0 0 2 2 2 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EWC45798.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EWC45798.1 - 0.022 14.7 0.3 0.039 13.8 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EWC45798.1 - 0.037 14.3 0.6 1.3 9.3 0.1 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EWC45798.1 - 0.19 11.8 1.3 17 5.5 0.2 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase RRP7 PF12923.7 EWC45800.1 - 6.5e-23 81.1 10.4 1.1e-22 80.3 10.4 1.3 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 EWC45800.1 - 2.3e-13 50.2 0.0 7.7e-13 48.6 0.0 1.9 1 1 0 1 1 1 1 Rrp7 RRM-like N-terminal domain DUF5102 PF17104.5 EWC45801.1 - 1.7e-80 271.1 9.5 4.1e-80 269.9 9.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF5102) FEZ PF07763.13 EWC45801.1 - 0.012 15.4 0.5 0.032 14.0 0.4 1.7 1 1 1 2 2 2 0 FEZ-like protein Pro_isomerase PF00160.21 EWC45802.1 - 6.7e-33 114.2 0.0 1.1e-32 113.5 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EWC45802.1 - 2.1e-14 53.1 0.1 3.6e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TMEM171 PF15471.6 EWC45803.1 - 0.17 10.8 7.4 0.21 10.5 6.8 1.5 1 1 0 1 1 1 0 Transmembrane protein family 171 MRP-L27 PF09809.9 EWC45804.1 - 5.6e-16 58.4 0.5 7.2e-16 58.0 0.5 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 LisH PF08513.11 EWC45805.1 - 0.038 13.9 0.2 0.064 13.2 0.2 1.4 1 0 0 1 1 1 0 LisH DUF2240 PF09999.9 EWC45805.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) TRAPP PF04051.16 EWC45806.1 - 9.7e-37 125.9 0.0 1.2e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4250 PF14056.6 EWC45806.1 - 0.045 13.7 0.1 0.099 12.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) WD40 PF00400.32 EWC45807.1 - 2.4e-34 116.8 9.2 5.5e-07 30.2 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC45807.1 - 2.1e-09 37.5 0.0 0.034 14.4 0.0 4.2 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EWC45807.1 - 9.6e-05 22.3 0.0 1.2 8.9 0.0 3.2 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A DUF2207 PF09972.9 EWC45808.1 - 0.11 11.3 6.0 0.15 10.8 6.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2892 PF11127.8 EWC45808.1 - 1 9.4 4.2 2.4 8.3 4.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2892) DUF4131 PF13567.6 EWC45808.1 - 1.3 8.6 4.4 2.3 7.8 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2205 PF10224.9 EWC45809.1 - 6.8e-36 122.1 0.9 8.7e-36 121.8 0.9 1.1 1 0 0 1 1 1 1 Short coiled-coil protein HOOK PF05622.12 EWC45809.1 - 0.0018 16.5 0.3 0.0021 16.3 0.3 1.0 1 0 0 1 1 1 1 HOOK protein Pup PF05639.11 EWC45809.1 - 0.016 16.1 0.8 0.025 15.5 0.8 1.3 1 0 0 1 1 1 0 Pup-like protein YabA PF06156.13 EWC45809.1 - 0.016 15.8 0.9 0.021 15.4 0.9 1.2 1 0 0 1 1 1 0 Initiation control protein YabA ARGLU PF15346.6 EWC45809.1 - 0.041 13.8 6.9 0.051 13.4 6.9 1.1 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Membr_traf_MHD PF10540.9 EWC45810.1 - 5.3e-18 65.6 0.4 3.8e-15 56.4 0.4 2.8 1 1 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EWC45810.1 - 1.9e-14 53.8 0.0 4.7e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 EWC45810.1 - 1.3e-07 30.6 0.3 2.1e-07 29.9 0.3 1.3 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) RPA43_OB PF17875.1 EWC45811.1 - 2.2e-17 63.8 0.1 2.2e-17 63.8 0.1 3.7 2 1 1 3 3 3 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EWC45811.1 - 2.4e-08 34.2 0.1 8.3e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 CDC45 PF02724.14 EWC45811.1 - 6.4 4.9 13.8 6.4 4.9 8.0 2.0 2 0 0 2 2 2 0 CDC45-like protein UDPGP PF01704.18 EWC45812.1 - 1.2e-53 182.3 0.0 1.6e-53 181.9 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EWC45812.1 - 0.1 13.0 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 MobA-like NTP transferase domain HAMP PF00672.25 EWC45813.1 - 9.2e-40 134.8 18.6 6.1e-09 36.1 0.2 7.8 6 3 1 7 7 7 5 HAMP domain HATPase_c PF02518.26 EWC45813.1 - 2.9e-32 111.5 0.1 9e-32 109.9 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EWC45813.1 - 9.5e-27 93.4 0.3 3.3e-26 91.7 0.3 2.0 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EWC45813.1 - 5.7e-17 61.5 0.5 5.7e-17 61.5 0.5 3.4 3 1 1 4 4 3 1 His Kinase A (phospho-acceptor) domain DUF4279 PF14106.6 EWC45813.1 - 9.6e-08 32.2 0.3 0.91 9.8 0.0 5.1 6 0 0 6 6 5 2 Domain of unknown function (DUF4279) Rpn9_C PF18261.1 EWC45813.1 - 0.0034 16.9 1.6 1.2 8.8 0.0 3.8 4 0 0 4 4 4 1 Rpn9 C-terminal helix IL32 PF15225.6 EWC45813.1 - 0.026 14.9 0.0 8.8 6.8 0.0 4.3 5 0 0 5 5 4 0 Interleukin 32 DUF3829 PF12889.7 EWC45813.1 - 0.04 13.4 13.7 2.9 7.3 0.1 5.0 3 2 2 5 5 5 0 Protein of unknown function (DUF3829) YscO-like PF16789.5 EWC45813.1 - 0.27 11.3 6.6 1.3 9.1 6.6 2.2 1 0 0 1 1 1 0 YscO-like protein PMC2NT PF08066.12 EWC45813.1 - 0.37 11.5 8.5 16 6.3 0.0 5.2 4 1 1 5 5 5 0 PMC2NT (NUC016) domain ImcF-related_N PF14331.6 EWC45813.1 - 0.37 10.1 2.4 46 3.2 0.0 4.1 3 1 1 4 4 4 0 ImcF-related N-terminal domain Cep57_MT_bd PF06657.13 EWC45813.1 - 0.91 10.0 4.8 19 5.8 2.7 4.1 4 0 0 4 4 3 0 Centrosome microtubule-binding domain of Cep57 BORCS6 PF10157.9 EWC45813.1 - 2.7 8.2 16.4 41 4.4 1.8 6.0 3 2 2 5 5 5 0 BLOC-1-related complex sub-unit 6 Sec34 PF04136.15 EWC45813.1 - 3 7.7 6.7 0.89 9.4 1.2 3.1 3 0 0 3 3 2 0 Sec34-like family OmpH PF03938.14 EWC45813.1 - 4 7.8 15.3 4.4 7.6 5.7 4.6 4 1 0 4 4 4 0 Outer membrane protein (OmpH-like) CENP-F_leu_zip PF10473.9 EWC45813.1 - 4.5 7.3 31.3 29 4.7 4.6 7.9 8 1 0 8 8 8 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 EWC45813.1 - 6.1 5.3 24.6 0.78 8.3 0.7 3.6 1 1 3 4 4 4 0 AAA domain SKA2 PF16740.5 EWC45813.1 - 7.2 6.4 9.1 9.2 6.1 2.6 3.9 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 WXG100 PF06013.12 EWC45813.1 - 8.8 6.6 25.9 0.94 9.8 0.1 7.1 7 2 1 8 8 8 0 Proteins of 100 residues with WXG SNF2_N PF00176.23 EWC45814.1 - 1.2e-66 224.8 0.1 2e-66 224.1 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC45814.1 - 1.3e-17 64.2 0.1 3.1e-17 62.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC45814.1 - 2e-12 47.4 0.0 4.9e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EWC45814.1 - 0.00053 19.8 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_25 PF13481.6 EWC45814.1 - 0.027 14.0 0.0 0.089 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EWC45814.1 - 0.097 12.7 0.0 5 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain NDUF_B8 PF05821.11 EWC45816.1 - 4.6e-05 23.3 0.1 7.1e-05 22.7 0.1 1.3 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) IATP PF04568.12 EWC45817.1 - 1.7e-20 73.3 0.1 2e-20 73.0 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP BLOC1_2 PF10046.9 EWC45817.1 - 0.029 14.7 1.0 0.041 14.2 1.0 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 EWC45817.1 - 0.063 13.1 2.8 0.099 12.4 2.8 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF1003 PF06210.11 EWC45817.1 - 0.25 11.4 1.4 0.37 10.9 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) XhlA PF10779.9 EWC45817.1 - 0.31 11.3 3.5 0.44 10.8 3.5 1.2 1 0 0 1 1 1 0 Haemolysin XhlA 14-3-3 PF00244.20 EWC45818.1 - 1.5e-107 358.1 7.1 1.8e-107 357.9 7.1 1.0 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 EWC45818.1 - 0.0097 14.3 3.2 0.017 13.5 3.2 1.3 1 0 0 1 1 1 1 Orbivirus outer capsid protein VP5 TPR_12 PF13424.6 EWC45818.1 - 0.062 13.6 1.0 0.71 10.2 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EWC45818.1 - 0.089 13.3 1.8 0.73 10.4 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-CCHC PF00098.23 EWC45819.1 - 1.7e-41 138.5 56.0 2.4e-09 36.9 2.8 6.7 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_4 PF14392.6 EWC45819.1 - 7.2e-08 32.0 34.2 0.2 11.4 0.8 6.1 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_5 PF14787.6 EWC45819.1 - 2.6e-07 30.2 36.1 0.005 16.5 0.8 6.2 4 1 2 6 6 6 5 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 EWC45819.1 - 8.6e-06 25.6 37.8 0.019 14.9 0.1 6.0 3 2 2 5 5 5 4 Zinc knuckle zf-CCHC_2 PF13696.6 EWC45819.1 - 0.041 13.7 1.5 0.041 13.7 1.5 6.2 6 0 0 6 6 6 0 Zinc knuckle zf-CCHC_6 PF15288.6 EWC45819.1 - 0.24 11.3 40.1 0.54 10.1 1.4 6.0 5 1 1 6 6 6 0 Zinc knuckle Rad51 PF08423.11 EWC45820.1 - 2.6e-110 367.7 0.0 3.4e-110 367.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EWC45820.1 - 8.6e-14 51.6 0.1 1.2e-13 51.1 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EWC45820.1 - 1.5e-07 31.0 0.0 3.1e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 EWC45820.1 - 8.8e-06 25.4 0.0 1.3e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EWC45820.1 - 0.00014 22.4 0.4 0.00014 22.4 0.4 2.4 3 0 0 3 3 3 1 Helix-hairpin-helix domain PAXNEB PF05625.11 EWC45820.1 - 0.046 12.9 0.1 0.073 12.2 0.1 1.2 1 0 0 1 1 1 0 PAXNEB protein dsrm PF00035.26 EWC45821.1 - 7.5e-06 26.6 0.0 0.13 13.0 0.0 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EWC45821.1 - 0.0017 18.6 0.2 0.79 10.0 0.0 2.6 2 0 0 2 2 2 2 double strand RNA binding domain from DEAD END PROTEIN 1 Ndc80_HEC PF03801.13 EWC45821.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 HEC/Ndc80p family RRM_1 PF00076.22 EWC45824.1 - 3.5e-45 151.7 0.0 9e-17 60.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EWC45824.1 - 1.6e-05 24.8 0.1 0.0018 18.2 0.0 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EWC45824.1 - 1.6e-05 24.8 0.0 0.0014 18.6 0.0 2.6 3 0 0 3 3 3 1 RNA binding motif RRM_occluded PF16842.5 EWC45824.1 - 5.2e-05 23.0 0.0 0.068 13.0 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EWC45824.1 - 0.0046 17.1 0.3 0.06 13.5 0.0 2.7 3 1 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.6 EWC45824.1 - 0.016 14.8 0.0 0.16 11.6 0.0 2.4 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tcp11 PF05794.13 EWC45825.1 - 5.4e-90 302.6 0.2 6.3e-90 302.4 0.2 1.0 1 0 0 1 1 1 1 T-complex protein 11 SeqA_N PF17206.3 EWC45825.1 - 0.061 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 SeqA protein N-terminal domain Lambda_tail_I PF06805.12 EWC45825.1 - 0.18 12.2 0.0 0.44 10.9 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage lambda tail assembly protein I DENN PF02141.21 EWC45826.1 - 8.4e-43 146.5 1.3 1.4e-42 145.7 1.3 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain IL10 PF00726.17 EWC45826.1 - 0.21 11.1 0.1 0.37 10.3 0.1 1.3 1 0 0 1 1 1 0 Interleukin 10 PP2C PF00481.21 EWC45827.1 - 1.7e-80 270.4 0.0 2.2e-80 270.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C CTF_NFI PF00859.18 EWC45828.1 - 0.0089 16.0 3.2 0.014 15.3 3.2 1.7 1 1 0 1 1 1 1 CTF/NF-I family transcription modulation region WD40 PF00400.32 EWC45829.1 - 1.1e-14 54.5 6.1 0.004 18.0 0.1 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC45829.1 - 6.1e-08 32.8 0.0 0.0013 19.0 0.0 4.6 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC45829.1 - 0.18 10.4 0.2 0.33 9.5 0.0 1.5 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Peptidase_S10 PF00450.22 EWC45830.1 - 4.9e-113 378.7 0.0 6.3e-113 378.3 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase EF-1_beta_acid PF10587.9 EWC45830.1 - 1.3 9.5 5.7 3.2 8.3 5.7 1.6 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Med18 PF09637.10 EWC45831.1 - 3.6e-46 158.0 0.0 7.4e-46 157.0 0.0 1.5 1 1 0 1 1 1 1 Med18 protein Endosulfine PF04667.17 EWC45832.1 - 1e-29 102.5 1.4 1.6e-29 101.9 0.2 1.8 2 0 0 2 2 2 1 cAMP-regulated phosphoprotein/endosulfine conserved region G-patch PF01585.23 EWC45833.1 - 3.5e-10 39.6 2.5 7e-10 38.6 2.5 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EWC45833.1 - 1.1e-07 31.5 0.0 5.9e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UCR_14kD PF02271.16 EWC45834.1 - 4.8e-43 145.2 0.3 5.5e-43 145.0 0.3 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit She9_MDM33 PF05546.11 EWC45834.1 - 0.021 14.6 0.0 0.025 14.4 0.0 1.1 1 0 0 1 1 1 0 She9 / Mdm33 family Recep_L_domain PF01030.24 EWC45835.1 - 3.1e-09 37.0 0.1 0.0029 17.7 0.0 4.6 1 1 4 5 5 5 4 Receptor L domain Ecm33 PF12454.8 EWC45835.1 - 9.1e-06 25.7 0.6 2.7e-05 24.2 0.6 1.9 1 0 0 1 1 1 1 GPI-anchored cell wall organization protein LRR_5 PF13306.6 EWC45835.1 - 0.0055 16.7 0.0 0.61 10.0 0.0 2.4 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) Ins_P5_2-kin PF06090.12 EWC45836.1 - 1.3e-42 146.4 0.0 1.7e-42 146.1 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase FAA_hydrolase PF01557.18 EWC45837.1 - 1.5e-48 165.4 0.0 1.8e-48 165.1 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Aconitase PF00330.20 EWC45838.1 - 3e-127 425.4 0.0 6.6e-117 391.3 0.0 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EWC45838.1 - 3.2e-39 134.3 0.0 4.4e-38 130.6 0.0 2.3 2 0 0 2 2 2 1 Aconitase C-terminal domain bZIP_2 PF07716.15 EWC45839.1 - 3.3e-13 49.5 8.3 5.8e-13 48.7 8.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EWC45839.1 - 2.3e-05 24.4 7.9 4.5e-05 23.4 7.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor DUF737 PF05300.11 EWC45839.1 - 0.0018 18.6 6.2 0.0022 18.4 6.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF737) FlgN PF05130.12 EWC45839.1 - 0.014 15.9 1.4 0.019 15.4 1.4 1.2 1 0 0 1 1 1 0 FlgN protein SOGA PF11365.8 EWC45839.1 - 0.018 16.1 4.0 0.03 15.4 4.0 1.4 1 0 0 1 1 1 0 Protein SOGA TSC22 PF01166.18 EWC45839.1 - 0.066 13.5 0.3 0.066 13.5 0.3 2.0 2 1 0 2 2 2 0 TSC-22/dip/bun family Cdh1_DBD_1 PF18196.1 EWC45839.1 - 0.078 13.3 2.1 0.14 12.5 2.1 1.4 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 WDCP PF15390.6 EWC45839.1 - 0.085 11.2 1.8 0.089 11.2 1.8 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family bZIP_Maf PF03131.17 EWC45839.1 - 0.17 12.4 6.9 0.26 11.8 6.6 1.5 1 1 0 1 1 1 0 bZIP Maf transcription factor XhlA PF10779.9 EWC45839.1 - 0.31 11.3 2.1 0.57 10.4 2.1 1.4 1 0 0 1 1 1 0 Haemolysin XhlA MHYT PF03707.16 EWC45841.1 - 1.5e-15 57.0 11.5 4.2e-07 30.0 2.8 4.4 4 0 0 4 4 4 2 Bacterial signalling protein N terminal repeat RRM_9 PF18444.1 EWC45841.1 - 0.085 12.7 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif S36_mt PF10937.8 EWC45842.1 - 5.6e-25 89.2 1.3 3.8e-24 86.5 1.3 1.9 1 1 0 1 1 1 1 Ribosomal protein S36, mitochondrial Annexin PF00191.20 EWC45843.1 - 1.2e-31 108.5 0.0 5e-07 29.7 0.0 4.3 4 0 0 4 4 4 4 Annexin Anp1 PF03452.14 EWC45844.1 - 3.3e-106 354.5 0.0 4e-106 354.3 0.0 1.1 1 0 0 1 1 1 1 Anp1 PP2C PF00481.21 EWC45845.1 - 1.1e-41 143.2 0.0 2e-41 142.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EWC45845.1 - 0.063 13.2 0.0 7.9 6.3 0.0 2.5 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) PNK3P PF08645.11 EWC45846.1 - 8e-56 188.2 0.0 1.2e-55 187.6 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EWC45846.1 - 1.4e-16 60.9 0.0 5.9e-14 52.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 EWC45846.1 - 0.013 15.0 0.2 0.7 9.3 0.2 2.2 1 1 0 1 1 1 0 Chromatin associated protein KTI12 APS_kinase PF01583.20 EWC45846.1 - 0.065 13.1 0.0 8.2 6.3 0.0 2.3 1 1 1 2 2 2 0 Adenylylsulphate kinase AAA_29 PF13555.6 EWC45846.1 - 0.069 12.9 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain RNR_inhib PF08591.10 EWC45846.1 - 0.11 13.8 0.0 0.33 12.3 0.0 1.8 1 0 0 1 1 1 0 Ribonucleotide reductase inhibitor Hydrolase_like PF13242.6 EWC45846.1 - 0.18 11.9 0.0 0.79 9.8 0.0 2.0 1 1 0 1 1 1 0 HAD-hyrolase-like ATPase PF06745.13 EWC45846.1 - 0.21 10.9 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 KaiC Methyltransf_16 PF10294.9 EWC45848.1 - 1.3e-45 155.2 0.0 1.6e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase AAA_18 PF13238.6 EWC45850.1 - 1.4e-09 38.5 0.0 2.7e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EWC45850.1 - 2.3e-05 24.8 0.0 3.9e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EWC45850.1 - 0.007 16.5 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EWC45850.1 - 0.027 13.9 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 EWC45850.1 - 0.047 13.6 0.0 0.089 12.7 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase CPT PF07931.12 EWC45850.1 - 0.16 11.8 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DUF5102 PF17104.5 EWC45851.1 - 0.76 9.8 7.5 1.1 9.3 6.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5102) DUF1977 PF09320.11 EWC45852.1 - 4.6e-26 91.1 0.2 4.6e-26 91.1 0.2 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EWC45852.1 - 2.3e-24 85.3 0.2 4e-24 84.5 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain Alginate_lyase PF05426.12 EWC45852.1 - 0.092 12.3 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Alginate lyase Y_phosphatase2 PF03162.13 EWC45853.1 - 9.1e-57 191.2 0.0 1.3e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EWC45853.1 - 3.8e-07 30.3 0.0 5.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EWC45853.1 - 6e-06 26.1 0.0 8.6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EWC45853.1 - 0.0014 18.3 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase HhH-GPD PF00730.25 EWC45855.1 - 5.3e-14 52.6 0.3 1.7e-13 51.0 0.0 1.9 2 1 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein Ima1_N PF09779.9 EWC45857.1 - 6.7e-21 75.6 4.2 7.7e-21 75.4 4.2 1.0 1 0 0 1 1 1 1 Ima1 N-terminal domain zf-Sec23_Sec24 PF04810.15 EWC45857.1 - 0.029 14.4 8.6 0.18 11.9 0.3 3.3 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger HypA PF01155.19 EWC45857.1 - 0.061 13.4 4.0 1.4 9.0 0.8 2.1 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Elf1 PF05129.13 EWC45857.1 - 0.2 11.7 9.3 2.6 8.1 0.3 2.9 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.6 EWC45857.1 - 0.9 10.1 9.0 1.8 9.1 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger double domain Ephrin_rec_like PF07699.13 EWC45857.1 - 2 8.2 12.7 1.1 9.0 4.9 3.1 2 1 1 3 3 3 0 Putative ephrin-receptor like CpXC PF14353.6 EWC45857.1 - 5 7.2 7.9 3.1 7.9 2.9 2.6 1 1 2 3 3 3 0 CpXC protein Zn_Tnp_IS1595 PF12760.7 EWC45857.1 - 6 6.9 9.7 6.6 6.8 2.7 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain ICE2 PF08426.10 EWC45858.1 - 3.3e-134 448.0 2.0 3.8e-134 447.8 2.0 1.0 1 0 0 1 1 1 1 ICE2 LptF_LptG PF03739.14 EWC45858.1 - 5.2 5.8 13.0 0.27 10.1 7.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG YCII PF03795.14 EWC45860.1 - 2.2e-07 31.2 0.0 2.7e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Vfa1 PF08432.10 EWC45861.1 - 1.9e-45 155.4 12.5 2.2e-45 155.2 12.5 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 SpoIIIAH PF12685.7 EWC45861.1 - 0.0052 16.7 8.0 0.0063 16.4 8.0 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein DUF4407 PF14362.6 EWC45861.1 - 0.078 12.3 5.1 0.09 12.1 5.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5308 PF17233.2 EWC45861.1 - 0.11 12.8 0.2 0.14 12.4 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) RPN2_C PF18004.1 EWC45861.1 - 0.54 10.2 16.0 0.84 9.5 16.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SIR4_SID PF16991.5 EWC45861.1 - 0.62 10.1 11.0 2.5 8.1 11.0 1.8 1 1 0 1 1 1 0 Sir4 SID domain PIEZO PF15917.5 EWC45861.1 - 1.3 8.5 16.6 2 7.9 16.6 1.3 1 1 0 1 1 1 0 Piezo Connexin PF00029.19 EWC45861.1 - 1.8 8.3 4.1 2.2 8.0 4.1 1.3 1 0 0 1 1 1 0 Connexin Rtf2 PF04641.12 EWC45861.1 - 2.2 7.6 17.4 3 7.1 17.2 1.4 1 1 0 1 1 1 0 Rtf2 RING-finger AAA_lid_9 PF17871.1 EWC45861.1 - 3.2 7.7 12.4 1.7 8.6 10.1 1.7 1 1 1 2 2 2 0 AAA lid domain TatD_DNase PF01026.21 EWC45863.1 - 1.9e-50 171.7 0.0 2.3e-50 171.4 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase BRCA-2_OB1 PF09103.10 EWC45863.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Alg14 PF08660.11 EWC45864.1 - 1.7e-32 112.7 0.0 2.8e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like KOW PF00467.29 EWC45865.1 - 0.021 14.8 4.6 0.052 13.5 4.6 1.7 1 0 0 1 1 1 0 KOW motif Lactamase_B PF00753.27 EWC45866.1 - 9.9e-20 71.4 0.5 2e-19 70.4 0.5 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 EWC45866.1 - 8.7e-17 60.8 0.1 1.5e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 EWC45866.1 - 1.2e-09 38.0 0.1 1.8e-09 37.4 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CENP-N PF05238.13 EWC45867.1 - 3.7e-73 247.2 0.0 4.6e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like zf-P11 PF03854.14 EWC45867.1 - 0.14 11.8 0.3 1.7 8.3 0.0 2.2 2 0 0 2 2 2 0 P-11 zinc finger AMP-binding PF00501.28 EWC45868.1 - 5.1e-92 308.7 0.0 6.5e-92 308.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC45868.1 - 5.4e-16 59.3 0.3 1.4e-15 58.0 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EWC45868.1 - 6.6e-05 22.0 0.0 0.0025 16.7 0.0 2.1 2 0 0 2 2 2 2 GH3 auxin-responsive promoter PEPcase_2 PF14010.6 EWC45868.1 - 0.028 13.0 0.1 0.038 12.5 0.1 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase DUF647 PF04884.14 EWC45869.1 - 8.7e-101 336.6 2.2 1.2e-100 336.1 2.2 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis RGS PF00615.19 EWC45870.1 - 9.8e-11 42.0 0.0 1.6e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Snapin_Pallidin PF14712.6 EWC45871.1 - 0.0023 18.3 0.2 0.0039 17.6 0.2 1.4 1 0 0 1 1 1 1 Snapin/Pallidin BBS2_C PF14782.6 EWC45871.1 - 0.012 14.4 0.2 0.014 14.2 0.2 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal IFRD_C PF04836.12 EWC45871.1 - 0.57 10.8 4.3 1.4 9.6 4.3 1.6 1 0 0 1 1 1 0 Interferon-related protein conserved region TetR_C_15 PF17918.1 EWC45871.1 - 3.2 8.5 14.5 0.33 11.7 5.4 2.2 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Tcp11 PF05794.13 EWC45872.1 - 1.2e-90 304.7 1.6 1.2e-90 304.7 1.6 2.8 3 1 0 3 3 3 1 T-complex protein 11 Stathmin PF00836.19 EWC45872.1 - 3.1 7.7 15.1 3 7.8 4.1 3.1 1 1 1 2 2 2 0 Stathmin family FtsA PF14450.6 EWC45873.1 - 0.096 13.1 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Cell division protein FtsA DUF2890 PF11081.8 EWC45873.1 - 0.44 10.7 5.1 0.057 13.5 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) DUF4667 PF15700.5 EWC45873.1 - 1.8 8.6 10.4 7 6.7 10.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4667) K_channel_TID PF07941.11 EWC45873.1 - 2 8.9 5.3 1.8 9.1 0.4 2.4 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Aldo_ket_red PF00248.21 EWC45874.1 - 5.6e-36 124.2 0.0 9.3e-34 117.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family RhoGAP PF00620.27 EWC45875.1 - 9.6e-28 96.9 0.1 1.6e-27 96.2 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 EWC45875.1 - 3.8e-17 62.7 0.1 6.4e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EWC45875.1 - 0.054 13.2 0.0 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 CRAL/TRIO domain HMA PF00403.26 EWC45877.1 - 1.4e-05 25.4 0.3 4.4e-05 23.8 0.3 1.7 1 1 0 1 1 1 1 Heavy-metal-associated domain CnrY PF17524.2 EWC45878.1 - 1.3 9.3 5.3 0.15 12.3 0.6 1.9 2 0 0 2 2 2 0 Anti-sigma factor CnrY Steroid_dh PF02544.16 EWC45879.1 - 3.1e-20 72.7 2.3 3.2e-15 56.4 0.1 2.5 3 0 0 3 3 3 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EWC45879.1 - 0.00052 19.6 1.2 0.00052 19.6 1.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) zf-H2C2_2 PF13465.6 EWC45880.1 - 3.4e-12 46.2 9.9 1.7e-07 31.3 0.2 3.8 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EWC45880.1 - 3.9e-12 45.9 12.7 3.3e-06 27.2 2.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC45880.1 - 1.6e-08 34.6 11.3 0.00037 21.1 1.5 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EWC45880.1 - 2.8e-08 33.6 5.6 0.0003 20.7 0.3 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EWC45880.1 - 1.2e-06 28.6 0.9 0.081 13.2 0.1 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EWC45880.1 - 3.8e-05 23.9 1.4 0.012 16.0 0.2 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type Zn_ribbon_recom PF13408.6 EWC45880.1 - 0.0052 17.3 0.9 0.012 16.1 0.9 1.5 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain zf-Di19 PF05605.12 EWC45880.1 - 0.06 13.6 1.4 0.16 12.3 1.4 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 EWC45880.1 - 0.27 11.7 2.2 8.5 6.9 0.3 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 EWC45880.1 - 0.41 10.4 7.1 0.38 10.6 0.7 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type ANTAR PF03861.14 EWC45880.1 - 0.45 10.4 2.8 0.92 9.4 2.8 1.4 1 0 0 1 1 1 0 ANTAR domain LIM PF00412.22 EWC45880.1 - 0.81 10.0 3.1 16 5.8 0.2 2.4 1 1 1 2 2 2 0 LIM domain C5HCH PF17982.1 EWC45880.1 - 2.3 8.4 6.2 17 5.7 1.1 2.5 1 1 1 2 2 2 0 NSD Cys-His rich domain Ribosomal_S10 PF00338.22 EWC45881.1 - 6.4e-08 32.7 0.1 7.4e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Senescence PF06911.12 EWC45882.1 - 0.0047 17.3 1.1 0.0054 17.1 1.1 1.1 1 0 0 1 1 1 1 Senescence-associated protein Chlorosome_CsmC PF11098.8 EWC45882.1 - 2.5 8.1 10.2 14 5.7 10.2 1.9 1 1 0 1 1 1 0 Chlorosome envelope protein C Kelch_5 PF13854.6 EWC45883.1 - 1.9e-05 24.5 0.2 0.013 15.5 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 EWC45883.1 - 2.8e-05 24.2 1.2 6.6 7.2 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 EWC45883.1 - 3.5e-05 23.7 4.5 0.44 10.6 0.1 4.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EWC45883.1 - 0.002 18.3 9.7 2 8.8 0.1 5.6 6 0 0 6 6 6 1 Galactose oxidase, central domain DUF2207 PF09972.9 EWC45883.1 - 0.023 13.5 0.0 0.037 12.8 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Adeno_E3_CR2 PF02439.15 EWC45883.1 - 0.16 11.7 1.2 0.32 10.8 1.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 MtrG PF04210.13 EWC45883.1 - 0.2 11.6 0.2 0.49 10.3 0.2 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G MLANA PF14991.6 EWC45883.1 - 0.94 9.8 0.0 0.94 9.8 0.0 2.4 2 0 0 2 2 2 0 Protein melan-A YajC PF02699.15 EWC45883.1 - 1.6 8.7 0.0 1.6 8.7 0.0 2.9 2 1 1 3 3 2 0 Preprotein translocase subunit Zip PF02535.22 EWC45883.1 - 1.8 7.7 6.1 3 7.0 6.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter EphA2_TM PF14575.6 EWC45883.1 - 2 9.4 0.0 2 9.4 0.0 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Spt20 PF12090.8 EWC45883.1 - 7.6 6.1 25.1 15 5.1 25.1 1.4 1 0 0 1 1 1 0 Spt20 family Pkinase PF00069.25 EWC45884.1 - 7.1e-55 186.2 0.2 2.8e-36 125.2 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45884.1 - 2.1e-25 89.5 0.0 3.7e-24 85.4 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC45884.1 - 2.6e-05 23.7 0.5 5.5e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EWC45884.1 - 0.0014 17.5 0.1 0.0037 16.1 0.1 1.7 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EWC45884.1 - 0.012 15.5 2.1 0.067 13.1 2.1 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family MPS2 PF17060.5 EWC45885.1 - 0.0028 17.0 2.8 0.0048 16.2 2.8 1.3 1 0 0 1 1 1 1 Monopolar spindle protein 2 LUC7 PF03194.15 EWC45885.1 - 0.024 14.3 4.4 0.036 13.7 4.4 1.3 1 0 0 1 1 1 0 LUC7 N_terminus Zn_peptidase PF04228.13 EWC45885.1 - 0.1 12.0 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase DUF1839 PF08893.10 EWC45885.1 - 0.11 11.7 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) NPV_P10 PF05531.12 EWC45885.1 - 0.15 12.6 3.8 3.2 8.3 1.7 2.7 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TSNAXIP1_N PF15739.5 EWC45885.1 - 0.29 11.5 2.1 1 9.7 0.0 2.3 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus ATG16 PF08614.11 EWC45885.1 - 0.32 11.2 10.1 1.2 9.3 2.9 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Csm1_N PF18504.1 EWC45885.1 - 0.65 10.4 6.1 2.5 8.5 1.1 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain FlaC_arch PF05377.11 EWC45885.1 - 1.6 9.2 6.2 15 6.1 0.4 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 EWC45885.1 - 1.6 9.0 9.4 6.9 7.0 1.7 2.4 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fungal_TACC PF12709.7 EWC45885.1 - 1.7 9.2 6.3 5.9 7.4 0.5 2.9 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Spc7 PF08317.11 EWC45885.1 - 1.7 7.4 9.8 2.9 6.7 9.5 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EWC45885.1 - 2.4 7.4 6.8 3.9 6.7 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 EWC45885.1 - 3.3 8.4 11.1 0.14 12.8 1.4 2.9 3 0 0 3 3 2 0 SlyX Fez1 PF06818.15 EWC45885.1 - 3.9 7.9 9.8 3.1 8.2 8.0 1.7 1 1 0 1 1 1 0 Fez1 TMF_DNA_bd PF12329.8 EWC45885.1 - 3.9 7.5 14.5 5.2 7.1 2.8 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FAM76 PF16046.5 EWC45885.1 - 4.4 6.6 8.3 0.55 9.5 1.8 2.0 1 1 1 2 2 2 0 FAM76 protein YabA PF06156.13 EWC45885.1 - 5.1 7.8 8.7 3.5 8.3 2.7 2.6 1 1 1 2 2 2 0 Initiation control protein YabA Snapin_Pallidin PF14712.6 EWC45885.1 - 5.2 7.6 8.5 16 6.0 1.4 2.4 2 0 0 2 2 2 0 Snapin/Pallidin LPP PF04728.13 EWC45885.1 - 5.8 7.4 9.2 5.7 7.4 0.4 3.5 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Chorismate_synt PF01264.21 EWC45886.1 - 1.1e-138 461.4 0.0 1.3e-138 461.2 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase BPL_LplA_LipB PF03099.19 EWC45887.1 - 0.00017 21.5 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family tRNA-synt_1g PF09334.11 EWC45888.1 - 5.4e-153 509.4 0.1 7e-153 509.0 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EWC45888.1 - 1.5e-08 33.4 0.7 0.0035 15.7 0.0 3.2 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Yae1_N PF09811.9 EWC45889.1 - 6.4e-07 29.0 3.2 6.4e-07 29.0 3.2 1.7 2 0 0 2 2 2 1 Essential protein Yae1, N terminal Meth_synt_2 PF01717.18 EWC45891.1 - 6e-152 505.5 0.0 3e-147 490.1 0.0 2.5 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EWC45891.1 - 1.4e-122 409.1 0.0 1.7e-115 385.9 0.0 3.0 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 EWC45891.1 - 0.0045 16.2 0.0 0.97 8.5 0.0 2.9 3 0 0 3 3 3 2 Uroporphyrinogen decarboxylase (URO-D) Phage_XkdX PF09693.10 EWC45891.1 - 1 9.4 3.4 15 5.7 0.9 2.8 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) RasGEF PF00617.19 EWC45892.1 - 1.9e-53 181.3 0.0 3.9e-53 180.3 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EWC45892.1 - 1.1e-10 41.7 0.0 3.7e-10 40.0 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EWC45892.1 - 0.00015 21.3 0.0 0.0003 20.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC45892.1 - 0.00087 19.1 0.0 0.0022 17.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Propep_M14 PF02244.16 EWC45893.1 - 0.041 14.3 0.1 0.19 12.1 0.1 2.2 1 0 0 1 1 1 0 Carboxypeptidase activation peptide TMCO5 PF14992.6 EWC45893.1 - 3.2 7.3 24.2 0.094 12.3 2.0 3.3 2 1 0 2 2 2 0 TMCO5 family 3HCDH_N PF02737.18 EWC45894.1 - 4.6e-38 130.9 1.3 6.2e-38 130.5 1.3 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EWC45894.1 - 1.3e-34 118.6 0.0 2.3e-34 117.9 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EWC45894.1 - 0.07 13.3 0.1 0.14 12.3 0.1 1.5 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Med5 PF08689.10 EWC45896.1 - 2.6e-56 191.2 0.0 5.5e-55 186.8 0.0 2.3 2 1 0 2 2 2 2 Mediator complex subunit Med5 HTH_Tnp_4 PF13613.6 EWC45896.1 - 0.2 11.4 0.5 0.44 10.3 0.5 1.6 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Med5 PF08689.10 EWC45897.1 - 0.087 10.6 0.0 0.11 10.4 0.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit Med5 MHC_I_2 PF14586.6 EWC45897.1 - 0.24 11.3 0.0 0.31 10.9 0.0 1.1 1 0 0 1 1 1 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 ELFV_dehydrog PF00208.21 EWC45899.1 - 3.3e-79 266.0 1.8 4.1e-79 265.7 1.8 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EWC45899.1 - 9.1e-51 171.1 0.0 1.7e-50 170.2 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Thiolase_N PF00108.23 EWC45900.1 - 5e-15 55.6 0.0 1.4e-14 54.1 0.0 1.7 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EWC45900.1 - 1.1e-09 38.0 1.3 9.3e-09 35.0 0.0 2.5 1 1 1 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EWC45900.1 - 3.2e-06 26.9 0.0 0.0013 18.6 0.0 2.7 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III zf-CCHC_4 PF14392.6 EWC45901.1 - 0.042 13.6 0.6 0.12 12.2 0.4 1.9 2 0 0 2 2 2 0 Zinc knuckle CLIP1_ZNF PF16641.5 EWC45901.1 - 7.7 6.5 10.2 0.1 12.5 1.7 2.0 2 0 0 2 2 2 0 CLIP1 zinc knuckle 60KD_IMP PF02096.20 EWC45902.1 - 8.4e-10 38.8 0.1 3e-09 37.0 0.0 1.8 1 1 0 2 2 2 1 60Kd inner membrane protein ALG11_N PF15924.5 EWC45903.1 - 9.6e-75 251.2 3.1 7.7e-74 248.2 3.1 2.1 1 1 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EWC45903.1 - 5e-24 84.8 0.0 9.3e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EWC45903.1 - 1e-13 51.9 0.1 3.8e-13 50.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EWC45903.1 - 0.0005 20.1 0.9 0.00093 19.2 0.4 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EWC45903.1 - 0.012 16.1 1.2 0.032 14.7 1.2 1.8 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain Tcf25 PF04910.14 EWC45904.1 - 9.6e-74 248.5 0.0 1.5e-73 247.9 0.0 1.3 1 0 0 1 1 1 1 Transcriptional repressor TCF25 CAP_N PF01213.19 EWC45904.1 - 0.0011 18.5 0.4 0.0011 18.5 0.4 3.1 2 1 1 3 3 3 1 Adenylate cyclase associated (CAP) N terminal Nop53 PF07767.11 EWC45904.1 - 0.0061 16.0 11.7 0.011 15.1 11.7 1.3 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) PrsW-protease PF13367.6 EWC45904.1 - 0.04 13.4 0.7 0.064 12.7 0.7 1.2 1 0 0 1 1 1 0 PrsW family intramembrane metalloprotease DUF4604 PF15377.6 EWC45904.1 - 0.049 14.1 16.3 0.12 12.8 16.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) TPR_14 PF13428.6 EWC45904.1 - 0.059 14.2 0.5 4.4 8.4 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat SURF2 PF05477.11 EWC45904.1 - 0.67 9.6 12.9 1.2 8.8 12.9 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RRN3 PF05327.11 EWC45904.1 - 1 7.8 8.1 1.7 7.1 8.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Dicty_REP PF05086.12 EWC45904.1 - 2.4 6.1 6.0 3.3 5.6 6.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein S1-P1_nuclease PF02265.16 EWC45905.1 - 3.2e-69 233.6 0.0 5.9e-69 232.7 0.0 1.5 1 0 0 1 1 1 1 S1/P1 Nuclease Xpo1 PF08389.12 EWC45906.1 - 5.1e-09 36.4 0.7 5.4e-07 29.8 0.2 3.3 2 1 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 EWC45906.1 - 0.014 15.3 0.0 0.077 12.9 0.0 2.4 2 1 0 2 2 2 0 Importin-beta N-terminal domain HATPase_c PF02518.26 EWC45907.1 - 3.8e-26 91.8 0.0 1.1e-25 90.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EWC45907.1 - 1.1e-23 83.5 0.0 2.4e-23 82.4 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EWC45907.1 - 1.4e-17 63.5 0.3 4.3e-17 61.9 0.3 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EWC45907.1 - 6.6e-16 58.4 0.0 7.3e-15 55.0 0.0 2.6 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 EWC45907.1 - 4.3e-06 26.9 0.0 0.002 18.3 0.0 4.2 3 1 0 3 3 3 1 PAS fold PAS_9 PF13426.7 EWC45907.1 - 5.3e-06 26.6 0.0 0.0034 17.6 0.0 4.0 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 EWC45907.1 - 1.8e-05 24.7 0.0 0.0075 16.3 0.0 3.2 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.7 EWC45907.1 - 0.0084 16.1 0.0 2.8 8.0 0.0 3.3 3 0 0 3 3 3 1 PAS domain HATPase_c_3 PF13589.6 EWC45907.1 - 0.15 11.9 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mito_carr PF00153.27 EWC45908.1 - 2.9e-68 225.8 2.6 1.1e-23 82.9 0.2 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EWC45908.1 - 0.00015 21.0 1.1 0.15 11.2 0.0 3.2 1 1 1 3 3 3 3 Gammaproteobacterial serine protease Redoxin PF08534.10 EWC45909.1 - 1.5e-28 99.4 0.4 1.8e-28 99.1 0.4 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EWC45909.1 - 5.9e-09 35.9 0.0 7.6e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Ribonuc_red_lgC PF02867.15 EWC45910.1 - 4.8e-187 622.6 0.0 6.3e-187 622.3 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EWC45910.1 - 1.1e-25 89.4 0.1 3.6e-25 87.8 0.1 1.9 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EWC45910.1 - 1.3e-16 60.9 1.2 4.9e-16 59.1 0.1 2.4 2 0 0 2 2 2 1 ATP cone domain HEM4 PF02602.15 EWC45911.1 - 1.8e-35 122.3 0.0 2.2e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Myb_DNA-binding PF00249.31 EWC45912.1 - 1.4e-14 54.0 10.0 3.8e-11 43.0 0.1 4.1 3 1 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EWC45912.1 - 7.1e-13 48.6 1.1 5.1e-11 42.7 0.1 3.5 3 1 1 4 4 4 2 Myb-like DNA-binding domain Raffinose_syn PF05691.12 EWC45913.1 - 1.6e-49 168.5 7.0 3.8e-40 137.4 7.8 4.0 2 1 0 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 Melibiase PF02065.18 EWC45913.1 - 0.013 14.5 0.5 0.023 13.7 0.5 1.3 1 0 0 1 1 1 0 Melibiase GDPD PF03009.17 EWC45914.1 - 1.5e-10 41.3 0.0 2.3e-10 40.6 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Glyco_transf_20 PF00982.21 EWC45915.1 - 4.7e-152 507.0 0.0 9.6e-152 506.0 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EWC45915.1 - 7.2e-83 277.3 0.0 1.1e-82 276.6 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 EWC45915.1 - 2.1e-08 34.2 0.0 0.0015 18.3 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase NAD_kinase PF01513.21 EWC45915.1 - 0.071 12.3 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 ATP-NAD kinase BRD4_CDT PF17105.5 EWC45915.1 - 0.075 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 zf-C2H2 PF00096.26 EWC45916.1 - 4.7e-05 23.6 12.8 0.0024 18.2 1.7 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC45916.1 - 0.003 17.9 5.3 0.013 15.9 5.3 2.2 1 0 0 1 1 1 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC45916.1 - 0.2 12.6 17.3 0.67 11.0 1.4 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EWC45916.1 - 0.84 9.4 5.0 6.8 6.6 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF2231 PF09990.9 EWC45917.1 - 7.2e-05 23.2 0.8 0.00012 22.5 0.8 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2231) DUF962 PF06127.11 EWC45917.1 - 0.025 14.7 0.1 0.057 13.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF962) DUF2817 PF10994.8 EWC45918.1 - 0.0053 16.2 0.1 0.0067 15.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) EptA_B_N PF08019.12 EWC45918.1 - 0.0074 16.2 1.9 0.01 15.7 1.9 1.2 1 0 0 1 1 1 1 Phosphoethanolamine transferase EptA/EptB DC_STAMP PF07782.13 EWC45918.1 - 0.0077 16.1 0.0 0.0093 15.8 0.0 1.2 1 0 0 1 1 1 1 DC-STAMP-like protein Brr6_like_C_C PF10104.9 EWC45918.1 - 0.037 13.8 0.2 0.056 13.2 0.2 1.2 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain DotU PF09850.9 EWC45918.1 - 0.057 13.1 0.8 0.086 12.5 0.8 1.3 1 0 0 1 1 1 0 Type VI secretion system protein DotU Pkinase PF00069.25 EWC45919.1 - 3.1e-68 230.0 0.0 3.8e-68 229.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45919.1 - 4e-32 111.5 0.0 4.8e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EWC45919.1 - 0.00034 20.0 0.2 0.00054 19.4 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EWC45919.1 - 0.0026 16.7 0.5 0.0052 15.8 0.5 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EWC45919.1 - 0.0098 15.2 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EWC45919.1 - 0.037 13.9 0.1 0.062 13.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EWC45919.1 - 0.074 12.1 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.11 EWC45919.1 - 0.12 12.7 0.8 0.23 11.7 0.8 1.4 1 0 0 1 1 1 0 Gag protein p6 Sec23_trunk PF04811.15 EWC45920.1 - 1.6e-75 253.8 0.0 2.7e-75 253.1 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EWC45920.1 - 2.5e-18 65.8 1.5 4.9e-18 64.8 0.4 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EWC45920.1 - 2.8e-18 66.5 0.1 6.4e-18 65.3 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EWC45920.1 - 1.2e-16 60.4 4.2 2.6e-16 59.4 4.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EWC45920.1 - 2.5e-11 43.3 0.0 4.4e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat DUF3458_C PF17432.2 EWC45920.1 - 0.011 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3458_C) ARM repeats Vps36-NZF-N PF16988.5 EWC45920.1 - 0.021 14.2 0.2 0.047 13.1 0.2 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain EMG1 PF03587.14 EWC45921.1 - 1.2e-76 256.7 0.0 1.4e-76 256.5 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase UPF0524 PF15823.5 EWC45922.1 - 0.049 13.0 1.8 0.11 11.9 1.8 1.5 1 0 0 1 1 1 0 UPF0524 of C3orf70 Helicase_C_2 PF13307.6 EWC45923.1 - 1.2e-58 198.0 0.0 3.4e-58 196.6 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EWC45923.1 - 2e-47 161.0 0.4 4.4e-47 160.0 0.4 1.6 1 0 0 1 1 1 1 DEAD_2 HAUS6_N PF14661.6 EWC45923.1 - 0.019 14.6 1.3 25 4.4 0.0 2.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus AAA_22 PF13401.6 EWC45923.1 - 0.048 13.9 0.0 0.32 11.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain DUF1556 PF07590.11 EWC45924.1 - 0.031 14.6 3.4 0.069 13.5 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1556) COG5 PF10392.9 EWC45926.1 - 3.9e-36 124.1 1.6 3.9e-36 124.1 1.6 2.6 3 0 0 3 3 3 1 Golgi transport complex subunit 5 SPT6_acidic PF14632.6 EWC45926.1 - 0.02 15.5 0.5 0.037 14.6 0.5 1.3 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Dor1 PF04124.12 EWC45926.1 - 0.027 13.1 0.3 0.027 13.1 0.3 1.5 2 0 0 2 2 2 0 Dor1-like family Vps5 PF09325.10 EWC45926.1 - 0.68 9.4 2.6 5.6 6.4 0.1 2.4 2 0 0 2 2 2 0 Vps5 C terminal like MFS_1 PF07690.16 EWC45927.1 - 5.5e-06 25.6 31.3 2.2e-05 23.6 31.5 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily SecY PF00344.20 EWC45927.1 - 0.008 15.5 2.5 0.03 13.6 2.5 2.0 1 1 0 1 1 1 1 SecY translocase SnoaL_2 PF12680.7 EWC45928.1 - 0.033 14.8 0.1 0.08 13.6 0.1 1.7 1 0 0 1 1 1 0 SnoaL-like domain Abhydrolase_6 PF12697.7 EWC45929.1 - 0.17 12.5 17.3 0.017 15.8 9.4 2.8 2 1 1 3 3 3 0 Alpha/beta hydrolase family GAF_3 PF13492.6 EWC45930.1 - 8.4e-06 26.2 0.0 2.5e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EWC45930.1 - 0.00019 22.0 0.0 0.00056 20.6 0.0 1.8 1 0 0 1 1 1 1 GAF domain DPPIV_N PF00930.21 EWC45931.1 - 1.6e-109 365.9 0.3 2.3e-109 365.4 0.3 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EWC45931.1 - 1.2e-55 188.3 2.5 2e-55 187.5 1.8 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EWC45931.1 - 8.6e-05 22.3 0.5 0.013 15.1 0.2 2.3 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EWC45931.1 - 0.0002 22.0 0.1 0.13 12.8 0.0 2.8 2 1 1 3 3 3 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EWC45931.1 - 0.0012 18.6 0.3 0.011 15.4 0.2 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 EWC45931.1 - 0.0051 16.5 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 EWC45931.1 - 0.056 13.0 0.0 0.27 10.7 0.0 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family Cgr1 PF03879.14 EWC45932.1 - 1.4e-30 105.9 20.9 1.5e-30 105.7 20.9 1.0 1 0 0 1 1 1 1 Cgr1 family Mito_carr PF00153.27 EWC45933.1 - 1.1e-27 95.8 0.2 6.5e-19 67.7 0.1 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein zf-GRF PF06839.12 EWC45934.1 - 8.1e-07 29.0 1.8 1.9e-06 27.9 1.8 1.7 1 0 0 1 1 1 1 GRF zinc finger ATG16 PF08614.11 EWC45934.1 - 0.0013 19.0 11.5 0.0013 19.0 11.5 2.4 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) JAKMIP_CC3 PF16034.5 EWC45934.1 - 0.005 16.8 10.6 0.005 16.8 10.6 1.8 2 0 0 2 2 2 1 JAKMIP CC3 domain KASH_CCD PF14662.6 EWC45934.1 - 0.0092 15.8 17.4 0.016 15.1 8.4 2.3 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH DivIC PF04977.15 EWC45934.1 - 0.017 14.8 17.2 0.021 14.6 1.9 3.8 2 1 2 4 4 4 0 Septum formation initiator ZapB PF06005.12 EWC45934.1 - 0.019 15.4 19.7 0.11 13.0 7.5 3.1 1 1 1 2 2 2 0 Cell division protein ZapB DUF3971 PF13116.6 EWC45934.1 - 0.039 13.5 1.2 0.067 12.8 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function CENP-F_leu_zip PF10473.9 EWC45934.1 - 0.063 13.3 18.5 0.12 12.4 18.5 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_DNA_bd PF12329.8 EWC45934.1 - 0.073 13.1 18.8 0.61 10.1 7.9 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.8 EWC45934.1 - 0.15 12.2 11.3 0.076 13.1 7.2 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Cnn_1N PF07989.11 EWC45934.1 - 0.2 11.8 18.6 1.1 9.5 1.6 3.8 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 EWC45934.1 - 0.35 11.0 11.9 0.58 10.3 1.1 3.1 1 1 1 2 2 2 0 bZIP transcription factor CENP-H PF05837.12 EWC45934.1 - 0.39 11.1 11.8 1.3 9.5 4.8 3.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) YabA PF06156.13 EWC45934.1 - 0.46 11.2 11.1 2.2 9.0 2.9 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Rootletin PF15035.6 EWC45934.1 - 0.52 10.3 9.0 1.1 9.3 9.0 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Macoilin PF09726.9 EWC45934.1 - 1.1 7.7 11.9 4.8 5.6 11.9 1.8 1 1 0 1 1 1 0 Macoilin family HALZ PF02183.18 EWC45934.1 - 1.2 9.4 11.9 0.13 12.5 0.6 4.0 2 1 3 5 5 5 0 Homeobox associated leucine zipper TPR_MLP1_2 PF07926.12 EWC45934.1 - 1.8 8.7 13.8 0.18 11.9 5.2 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CCDC92 PF14916.6 EWC45934.1 - 3.1 7.6 10.0 0.27 11.0 0.8 2.9 3 1 0 3 3 2 0 Coiled-coil domain of unknown function DUF3450 PF11932.8 EWC45934.1 - 3.6 6.8 9.7 1.6 8.0 4.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 EWC45934.1 - 4.9 6.9 11.9 1.1 9.0 5.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 EWC45934.1 - 5.7 7.0 13.3 24 5.0 12.4 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GIT_CC PF16559.5 EWC45934.1 - 6.7 6.7 9.4 2.7 7.9 2.0 2.6 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Mto2_bdg PF12808.7 EWC45934.1 - 6.7 7.1 13.0 8.7 6.7 0.9 4.0 3 1 1 4 4 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region TolA_bind_tri PF16331.5 EWC45934.1 - 7.6 6.7 10.0 23 5.1 0.8 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation dCMP_cyt_deam_2 PF08211.12 EWC45935.1 - 6.5e-11 42.6 0.1 3e-08 34.0 0.0 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_1 PF00383.23 EWC45935.1 - 6.5e-11 42.0 0.0 7.9e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region DUF962 PF06127.11 EWC45936.1 - 1.4e-24 86.0 2.5 2.1e-24 85.4 2.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF962) SHS2_Rpb7-N PF03876.17 EWC45937.1 - 4.1e-14 52.7 0.0 8.7e-14 51.7 0.0 1.5 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EWC45937.1 - 5.7e-11 42.6 0.0 8.2e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain ATP-synt_ab PF00006.25 EWC45938.1 - 4.9e-72 242.0 0.0 7.1e-72 241.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EWC45938.1 - 1.2e-47 161.3 0.1 2.1e-47 160.6 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EWC45938.1 - 1.7e-15 57.3 2.6 4.2e-15 56.0 2.6 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RbcS PF12338.8 EWC45938.1 - 0.079 13.2 0.2 1.6 9.0 0.3 2.7 2 0 0 2 2 2 0 Ribulose-1,5-bisphosphate carboxylase small subunit Carb_kinase PF01256.17 EWC45939.1 - 1.9e-48 165.1 0.9 4.8e-38 131.0 0.1 2.2 1 1 1 2 2 2 2 Carbohydrate kinase Cpn60_TCP1 PF00118.24 EWC45941.1 - 3.8e-99 332.5 7.5 4.8e-99 332.2 7.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Tubulin PF00091.25 EWC45942.1 - 1.8e-62 211.0 0.0 2.5e-62 210.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EWC45942.1 - 5.2e-45 152.7 0.1 8e-45 152.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EWC45942.1 - 0.0023 17.6 0.0 0.0045 16.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Lipase_3 PF01764.25 EWC45942.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) SUI1 PF01253.22 EWC45943.1 - 2.4e-23 82.5 0.6 4.2e-23 81.7 0.6 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF3055 PF11256.8 EWC45943.1 - 0.036 14.3 0.1 0.074 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3055) Cytidylate_kin2 PF13189.6 EWC45943.1 - 0.039 14.1 2.5 1.5 8.9 0.1 2.1 2 0 0 2 2 2 0 Cytidylate kinase-like family PqqD PF05402.12 EWC45943.1 - 0.29 11.5 0.4 0.29 11.5 0.4 1.8 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) O-FucT PF10250.9 EWC45944.1 - 0.04 13.6 0.0 0.42 10.3 0.0 2.0 2 0 0 2 2 2 0 GDP-fucose protein O-fucosyltransferase FAD_binding_2 PF00890.24 EWC45945.1 - 2e-124 415.9 2.5 2.5e-124 415.6 2.5 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EWC45945.1 - 6.7e-43 145.7 0.1 1e-42 145.2 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 EWC45945.1 - 1.1e-05 24.7 1.3 0.017 14.2 2.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EWC45945.1 - 1.1e-05 24.8 0.1 0.00062 19.1 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EWC45945.1 - 0.0001 21.6 0.2 0.032 13.5 0.1 2.4 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EWC45945.1 - 0.0024 17.2 0.5 0.0058 15.9 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EWC45945.1 - 0.0037 16.9 1.2 0.066 12.8 1.2 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EWC45945.1 - 0.13 10.9 0.7 0.31 9.7 0.4 1.8 2 0 0 2 2 2 0 HI0933-like protein AAA PF00004.29 EWC45946.1 - 8.9e-41 139.4 0.0 1.5e-40 138.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC45946.1 - 3.6e-07 29.9 0.0 8.4e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EWC45946.1 - 2.7e-05 24.2 0.0 8.9e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EWC45946.1 - 0.0001 22.6 0.0 0.0048 17.2 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EWC45946.1 - 0.00011 22.6 0.1 0.0019 18.6 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EWC45946.1 - 0.00027 21.1 0.0 0.00062 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EWC45946.1 - 0.00049 19.3 0.0 0.00088 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EWC45946.1 - 0.0019 17.9 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EWC45946.1 - 0.0079 15.7 0.0 0.022 14.3 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_28 PF13521.6 EWC45946.1 - 0.015 15.5 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EWC45946.1 - 0.021 15.0 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EWC45946.1 - 0.038 14.4 0.0 0.081 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EWC45946.1 - 0.039 13.8 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EWC45946.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EWC45946.1 - 0.055 12.7 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 EWC45946.1 - 0.064 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.6 EWC45946.1 - 0.064 13.8 0.0 0.16 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EWC45946.1 - 0.067 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EWC45946.1 - 0.081 13.0 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EWC45946.1 - 0.087 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 EWC45946.1 - 0.094 12.6 0.4 5.7 6.8 0.0 2.7 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EWC45946.1 - 0.11 12.9 0.1 1.6 9.1 0.0 2.6 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 EWC45946.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 EWC45946.1 - 0.19 11.5 0.0 0.58 9.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain ELMO_CED12 PF04727.13 EWC45947.1 - 3.5e-46 157.5 0.8 8.2e-46 156.3 0.8 1.6 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 EWC45947.1 - 4.4e-27 95.2 0.0 1.4e-26 93.6 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain DUF3361 PF11841.8 EWC45947.1 - 7.4e-14 52.0 0.0 6.7e-13 48.9 0.0 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF3361) RPN1_RPN2_N PF17781.1 EWC45947.1 - 0.044 13.2 0.3 0.077 12.4 0.3 1.7 1 1 0 1 1 1 0 RPN1/RPN2 N-terminal domain Glyco_hydro_77 PF02446.17 EWC45947.1 - 0.066 12.1 0.8 0.11 11.3 0.8 1.3 1 0 0 1 1 1 0 4-alpha-glucanotransferase DUF1752 PF08550.10 EWC45948.1 - 8.9e-12 44.6 5.2 1.8e-11 43.6 5.2 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) GPI-anchored PF10342.9 EWC45949.1 - 1.9e-23 83.0 3.0 1.9e-23 83.0 3.0 2.2 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Suf PF05843.14 EWC45949.1 - 0.17 11.9 1.1 0.2 11.6 1.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SWI-SNF_Ssr4 PF08549.10 EWC45949.1 - 0.31 9.6 4.0 0.35 9.5 4.0 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SPT2 PF08243.11 EWC45951.1 - 3.1e-08 34.1 13.1 3.1e-08 34.1 13.1 2.2 2 0 0 2 2 2 1 SPT2 chromatin protein Cys_Met_Meta_PP PF01053.20 EWC45953.1 - 8.9e-137 455.7 0.0 1e-136 455.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EWC45953.1 - 4.3e-06 26.1 0.0 6.2e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EWC45953.1 - 8.8e-05 22.0 0.5 0.00021 20.7 0.5 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EWC45953.1 - 0.0001 21.7 0.1 0.00027 20.3 0.1 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EWC45953.1 - 0.00013 21.0 1.2 0.00016 20.8 0.1 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Ribosomal_60s PF00428.19 EWC45954.1 - 3.5e-23 82.0 3.9 4e-23 81.8 3.9 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_S19 PF00203.21 EWC45955.1 - 6e-33 112.6 0.5 8.2e-33 112.1 0.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Sds3 PF08598.11 EWC45956.1 - 3.5e-19 69.7 2.9 3.5e-19 69.7 2.9 2.5 2 1 0 2 2 2 1 Sds3-like STIL_N PF15253.6 EWC45956.1 - 1.5 7.7 6.8 0.32 9.9 2.9 1.8 2 0 0 2 2 2 0 SCL-interrupting locus protein N-terminus RRM_1 PF00076.22 EWC45957.1 - 3.5e-22 78.0 0.0 4e-15 55.4 0.0 3.6 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EWC45957.1 - 0.00092 19.3 0.0 0.49 10.6 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif RRM_Rrp7 PF17799.1 EWC45957.1 - 0.11 12.4 0.0 21 4.9 0.0 2.5 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Spo7_2_N PF15407.6 EWC45957.1 - 0.16 11.6 0.0 0.52 10.0 0.0 1.8 2 0 0 2 2 2 0 Sporulation protein family 7 SRA1 PF07304.11 EWC45958.1 - 0.03 14.1 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) HepII_C PF18675.1 EWC45958.1 - 0.057 13.5 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Heparinase II C-terminal domain MMS19_C PF12460.8 EWC45959.1 - 1.1e-119 400.4 6.4 4.3e-118 395.1 0.6 3.6 3 1 0 3 3 3 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EWC45959.1 - 3.4e-95 318.6 2.8 1.4e-90 303.5 0.1 4.2 3 1 1 4 4 4 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 EWC45959.1 - 5.3e-05 23.6 11.7 0.0016 18.9 0.3 6.7 6 1 2 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.6 EWC45959.1 - 0.00028 21.2 7.8 0.046 14.1 0.1 4.5 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EWC45959.1 - 0.0078 16.4 6.0 2.1 8.8 0.1 5.1 5 0 0 5 5 5 1 HEAT repeat CTK3 PF12243.8 EWC45959.1 - 0.056 13.5 0.0 0.32 11.0 0.0 2.3 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 Adaptin_N PF01602.20 EWC45959.1 - 0.099 11.2 8.1 0.82 8.1 0.8 3.5 3 1 1 4 4 4 0 Adaptin N terminal region THF_DHG_CYH PF00763.23 EWC45960.1 - 5e-24 84.8 0.0 8.6e-24 84.0 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EWC45960.1 - 1.4e-14 53.7 0.1 1.7e-12 46.9 0.1 2.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DpaA_N PF16924.5 EWC45960.1 - 0.057 13.5 0.0 5.4 7.1 0.0 2.7 3 0 0 3 3 3 0 Dipicolinate synthase subunit A N-terminal domain Brix PF04427.18 EWC45961.1 - 2.4e-42 145.2 0.2 3.3e-42 144.8 0.2 1.2 1 0 0 1 1 1 1 Brix domain BDV_P24 PF06595.11 EWC45961.1 - 0.02 14.8 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Borna disease virus P24 protein Tim17 PF02466.19 EWC45962.1 - 1.1e-13 51.5 0.9 1.7e-13 50.9 0.9 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family BPD_transp_2 PF02653.16 EWC45962.1 - 0.0014 17.8 0.2 0.0023 17.2 0.2 1.2 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Nt_Gln_amidase PF09764.9 EWC45963.1 - 7.1e-42 143.1 0.0 1.3e-41 142.3 0.0 1.5 1 1 0 1 1 1 1 N-terminal glutamine amidase CBP4 PF07960.11 EWC45964.1 - 0.069 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 CBP4 FliP PF00813.20 EWC45964.1 - 0.14 12.0 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 FliP family SET PF00856.28 EWC45965.1 - 4.8e-14 53.1 0.0 1.2e-13 51.8 0.0 1.7 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 EWC45965.1 - 7.6e-08 32.3 9.5 7.6e-08 32.3 9.5 3.1 2 1 1 3 3 3 1 MYND finger DZR PF12773.7 EWC45965.1 - 0.012 15.7 8.5 0.012 15.7 8.5 2.6 2 1 0 2 2 2 0 Double zinc ribbon zf_UBZ PF18439.1 EWC45965.1 - 0.93 9.1 10.3 2 8.1 0.1 3.2 2 1 1 3 3 3 0 Ubiquitin-Binding Zinc Finger CpXC PF14353.6 EWC45965.1 - 1.8 8.6 5.7 1.3 9.1 1.0 2.4 1 1 1 2 2 2 0 CpXC protein CBF PF03914.17 EWC45966.1 - 7.6e-33 113.9 1.1 1.6e-32 112.9 0.3 2.0 2 0 0 2 2 2 1 CBF/Mak21 family Mt_ATP-synt_B PF05405.14 EWC45967.1 - 6.5e-46 155.9 8.7 8.2e-46 155.6 8.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Rep_trans PF02486.19 EWC45967.1 - 0.006 16.3 0.6 0.0092 15.7 0.6 1.3 1 0 0 1 1 1 1 Replication initiation factor AbiEii PF08843.11 EWC45968.1 - 7.9e-05 22.7 0.0 0.0002 21.4 0.0 1.9 1 1 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system DUF2204 PF09970.9 EWC45968.1 - 0.00034 20.3 0.0 0.00067 19.3 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF2204) DUF3453 PF11935.8 EWC45969.1 - 3.2e-64 216.7 4.3 1.8e-63 214.2 4.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) DUF1846 PF08903.11 EWC45969.1 - 0.052 12.1 0.6 0.082 11.4 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) PBP PF01161.20 EWC45971.1 - 2e-20 73.4 0.0 2.7e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein NUFIP1 PF10453.9 EWC45972.1 - 9.8e-11 41.3 4.1 9.8e-11 41.3 4.1 4.0 4 0 0 4 4 4 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf_CCCH_4 PF18345.1 EWC45972.1 - 8.7e-06 25.6 4.6 1.5e-05 24.9 4.6 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EWC45972.1 - 1.5e-05 24.8 1.4 2.7e-05 23.9 1.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EWC45972.1 - 4.9e-05 23.0 0.6 8.2e-05 22.3 0.6 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EWC45972.1 - 0.0021 18.7 0.0 0.0021 18.7 0.0 3.2 2 1 1 3 3 3 1 Torus domain zf-CCCH_2 PF14608.6 EWC45972.1 - 0.48 11.0 1.7 0.88 10.1 1.7 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Nucleocapsid-N PF11030.8 EWC45972.1 - 0.59 10.1 16.2 0.58 10.1 14.3 1.8 2 0 0 2 2 2 0 Nucleocapsid protein N RNA_pol_Rbc25 PF08292.12 EWC45974.1 - 2.4e-40 137.8 2.6 9.3e-40 135.8 2.6 1.8 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EWC45974.1 - 1.5e-14 54.1 0.0 2.6e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EWC45974.1 - 0.0035 17.7 0.2 0.0065 16.8 0.2 1.6 1 1 0 1 1 1 1 S1 RNA binding domain Sortilin-Vps10 PF15902.5 EWC45975.1 - 4.2e-290 961.9 13.8 2.2e-155 517.8 4.0 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EWC45975.1 - 1e-86 289.6 23.1 3.9e-43 147.7 4.7 2.7 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EWC45975.1 - 5e-14 50.0 35.9 1.1 9.5 0.2 11.2 10 0 0 10 10 10 8 BNR/Asp-box repeat BNR_6 PF15899.5 EWC45975.1 - 5.1e-05 22.9 4.1 21 5.5 0.0 6.7 7 0 0 7 7 7 1 BNR-Asp box repeat PSII_BNR PF14870.6 EWC45975.1 - 0.0001 21.7 3.3 2.3 7.4 0.1 5.0 4 1 0 4 4 4 1 Photosynthesis system II assembly factor YCF48 BNR_2 PF13088.6 EWC45975.1 - 0.014 14.7 8.1 6.1 6.1 0.0 5.9 5 2 1 6 6 6 0 BNR repeat-like domain CHB_HEX_C PF03174.13 EWC45975.1 - 1.6 8.8 12.2 2.6 8.1 0.1 5.7 8 0 0 8 8 8 0 Chitobiase/beta-hexosaminidase C-terminal domain preSET_CXC PF18264.1 EWC45975.1 - 6.2 7.4 11.4 9.1 6.9 1.4 2.7 2 0 0 2 2 2 0 CXC domain Mur_ligase_M PF08245.12 EWC45976.1 - 9.3e-10 38.8 0.0 2e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 EWC45976.1 - 0.00015 21.9 0.0 0.00029 21.0 0.0 1.4 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain HECT_2 PF09814.9 EWC45977.1 - 8.8e-80 268.3 0.0 1e-79 268.2 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Yippee-Mis18 PF03226.14 EWC45977.1 - 0.24 11.6 0.9 0.85 9.9 0.9 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Questin_oxidase PF14027.6 EWC45978.1 - 1.6e-70 238.4 0.6 1.9e-70 238.1 0.6 1.1 1 0 0 1 1 1 1 Questin oxidase-like TauD PF02668.16 EWC45979.1 - 3.5e-40 138.5 0.2 5e-40 138.0 0.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EWC45979.1 - 4.8e-05 23.9 0.0 0.00014 22.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF971) PAAR_motif PF05488.13 EWC45979.1 - 0.038 14.2 0.0 4.8 7.4 0.0 2.4 2 0 0 2 2 2 0 PAAR motif Dynamin_M PF01031.20 EWC45980.1 - 2.3e-109 365.0 0.0 5e-109 363.9 0.0 1.5 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EWC45980.1 - 4.5e-56 189.5 0.0 8.5e-56 188.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EWC45980.1 - 2.1e-31 107.9 2.8 7.7e-31 106.1 3.2 1.8 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EWC45980.1 - 0.00011 22.3 0.3 0.0015 18.6 0.3 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4726 PF15855.5 EWC45982.1 - 0.035 14.3 0.9 0.056 13.7 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4726) UAA PF08449.11 EWC45984.1 - 9e-90 300.9 14.2 1.1e-89 300.7 14.2 1.0 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EWC45984.1 - 0.0013 18.0 2.5 0.0013 18.0 2.5 2.3 2 1 0 2 2 2 1 Nucleotide-sugar transporter MAP65_ASE1 PF03999.12 EWC45984.1 - 0.28 9.8 3.3 0.38 9.4 3.3 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TPT PF03151.16 EWC45984.1 - 0.33 10.2 11.9 0.73 9.1 11.9 1.6 1 1 0 1 1 1 0 Triose-phosphate Transporter family TssN PF17555.2 EWC45984.1 - 4.4 6.6 7.4 0.35 10.2 1.2 2.0 2 0 0 2 2 2 0 Type VI secretion system, TssN EamA PF00892.20 EWC45984.1 - 5.2 7.2 31.0 8.2 6.6 11.1 3.1 2 2 0 2 2 2 0 EamA-like transporter family DUF2457 PF10446.9 EWC45984.1 - 9.1 5.3 8.0 16 4.5 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SIL1 PF16782.5 EWC45985.1 - 6.8e-17 61.6 0.0 9.3e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 SRTM1 PF15872.5 EWC45985.1 - 0.13 12.5 0.2 0.23 11.6 0.2 1.4 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 IBN_N PF03810.19 EWC45985.1 - 0.15 12.0 0.1 0.4 10.6 0.1 1.8 1 1 0 1 1 1 0 Importin-beta N-terminal domain SPC25 PF06703.11 EWC45986.1 - 1.2e-49 168.2 0.1 1.4e-49 168.0 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) EMC3_TMCO1 PF01956.16 EWC45987.1 - 1.5e-56 190.7 2.4 2.4e-56 190.1 2.4 1.3 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Pkinase PF00069.25 EWC45988.1 - 9.7e-62 208.7 0.0 3.3e-38 131.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC45988.1 - 3.6e-27 95.3 0.0 3.3e-19 69.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EWC45988.1 - 4.8e-13 49.3 0.1 9.5e-13 48.3 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EWC45988.1 - 3.5e-07 29.8 0.0 1e-05 25.0 0.0 2.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EWC45988.1 - 0.00031 20.7 0.2 0.0037 17.2 0.2 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EWC45988.1 - 0.011 14.7 0.1 0.029 13.3 0.1 1.7 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EWC45988.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EWC45988.1 - 0.024 14.3 0.0 2.2 7.9 0.0 2.5 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PPL4 PF18188.1 EWC45988.1 - 0.041 13.8 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 Prim-pol 4 RIO1 PF01163.22 EWC45988.1 - 0.068 12.8 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EWC45988.1 - 0.077 11.8 0.1 0.23 10.2 0.1 1.7 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 EWC45988.1 - 0.18 10.8 0.1 0.3 10.1 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 CBFB_NFYA PF02045.15 EWC45989.1 - 2.2e-28 98.6 4.5 4.8e-28 97.5 4.5 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Hus1 PF04005.12 EWC45989.1 - 0.11 11.6 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Hus1-like protein Nbl1_Borealin_N PF10444.9 EWC45990.1 - 1.1e-13 50.5 1.0 1.1e-13 50.5 1.0 1.7 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal VWA_2 PF13519.6 EWC45991.1 - 3.1e-24 85.7 0.0 1.1e-23 84.0 0.0 1.9 1 1 1 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.14 EWC45991.1 - 5.1e-08 33.0 0.0 7.1e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 EWC45991.1 - 0.011 15.6 0.7 0.037 13.9 0.7 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif PGA2 PF07543.12 EWC45991.1 - 0.064 13.2 4.7 0.12 12.4 4.7 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 Kinesin PF00225.23 EWC45992.1 - 1.1e-109 366.4 0.0 2.1e-109 365.5 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 EWC45992.1 - 3e-38 131.8 12.5 1.4e-29 103.6 0.6 3.6 2 1 1 3 3 3 2 Kinesin-associated DUF3694 PF12473.8 EWC45992.1 - 1.8e-37 129.3 0.4 1.8e-37 129.3 0.4 2.0 2 0 0 2 2 2 1 Kinesin protein Microtub_bd PF16796.5 EWC45992.1 - 6.3e-26 91.1 0.0 2e-25 89.5 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 EWC45992.1 - 2.2e-07 31.3 0.0 9.5e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 PH domain KIF1B PF12423.8 EWC45992.1 - 1.3e-05 25.6 0.0 4.5e-05 23.8 0.0 2.1 1 0 0 1 1 1 1 Kinesin protein 1B PH_9 PF15410.6 EWC45992.1 - 0.065 13.6 0.8 0.26 11.7 0.1 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain B_lectin PF01453.24 EWC45993.1 - 4.9e-09 36.7 0.1 2.1e-05 25.0 0.0 2.0 1 1 1 2 2 2 2 D-mannose binding lectin Mito_carr PF00153.27 EWC45994.1 - 9.4e-57 188.9 2.3 3e-18 65.5 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein LRR_6 PF13516.6 EWC45995.1 - 1.3e-11 43.5 15.3 0.11 12.6 0.1 8.4 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 EWC45995.1 - 0.00013 22.0 0.8 71 4.6 0.2 5.9 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 EWC45995.1 - 0.00066 19.4 10.5 0.36 10.6 0.3 5.2 5 1 0 5 5 5 2 Leucine rich repeat LRR_4 PF12799.7 EWC45995.1 - 0.0015 18.9 16.8 6.1 7.4 0.2 6.4 4 3 2 6 6 6 3 Leucine Rich repeats (2 copies) NOA36 PF06524.12 EWC45995.1 - 0.25 10.6 4.2 0.34 10.2 4.2 1.2 1 0 0 1 1 1 0 NOA36 protein COX17 PF05051.13 EWC45996.1 - 3.2e-20 72.2 5.6 4e-20 71.9 5.6 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EWC45996.1 - 0.0082 16.1 1.8 2.6 8.1 0.3 2.1 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like TAFII55_N PF04658.13 EWC45997.1 - 6.7e-50 168.9 0.1 1.7e-49 167.7 0.1 1.7 1 0 0 1 1 1 1 TAFII55 protein conserved region Bromo_TP PF07524.13 EWC45998.1 - 4.4e-14 52.2 0.0 7.4e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TrmB PF01978.19 EWC45998.1 - 0.04 13.8 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sel1 PF08238.12 EWC46000.1 - 6.3e-15 55.3 6.1 0.0001 22.9 0.0 4.3 4 0 0 4 4 4 3 Sel1 repeat Alg6_Alg8 PF03155.15 EWC46001.1 - 1.8e-144 482.3 13.2 2.1e-144 482.1 13.2 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family SpoVAB PF13782.6 EWC46001.1 - 0.77 10.1 5.2 0.3 11.4 1.3 2.3 2 0 0 2 2 2 0 Stage V sporulation protein AB Pkinase PF00069.25 EWC46002.1 - 6.7e-48 163.3 0.0 1.1e-47 162.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46002.1 - 2.2e-22 79.6 0.0 3.4e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC46002.1 - 0.0056 16.6 0.1 0.043 13.7 0.2 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EWC46002.1 - 0.02 14.3 0.1 0.037 13.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EWC46002.1 - 0.043 13.4 0.4 0.09 12.4 0.1 1.6 2 0 0 2 2 2 0 RIO1 family Kinase-like PF14531.6 EWC46002.1 - 0.043 13.1 0.0 0.075 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EWC46002.1 - 0.14 10.9 0.0 0.14 10.9 0.0 2.1 3 0 0 3 3 3 0 Fungal protein kinase PsaA_PsaB PF00223.19 EWC46002.1 - 0.27 9.4 0.0 0.38 8.9 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein bZIP_1 PF00170.21 EWC46003.1 - 4e-07 30.0 9.5 4e-07 30.0 9.5 2.6 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 EWC46003.1 - 2.4e-06 28.0 6.6 2.4e-06 28.0 6.6 3.1 3 0 0 3 3 3 1 bZIP Maf transcription factor bZIP_2 PF07716.15 EWC46003.1 - 7.1e-05 22.8 10.1 7.1e-05 22.8 10.1 2.6 2 0 0 2 2 2 1 Basic region leucine zipper OrfB_IS605 PF01385.19 EWC46003.1 - 0.092 13.0 5.0 0.063 13.5 2.1 2.2 2 0 0 2 2 2 0 Probable transposase zf-CCCH PF00642.24 EWC46004.1 - 0.0024 17.7 6.6 0.0088 15.9 1.4 2.3 1 1 1 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EWC46004.1 - 0.0093 16.0 1.2 0.0093 16.0 1.2 2.1 2 0 0 2 2 2 1 Zinc finger domain zf-C3H1 PF10650.9 EWC46004.1 - 0.55 10.0 7.3 0.094 12.5 2.1 2.3 2 1 0 2 2 2 0 Putative zinc-finger domain F-box-like PF12937.7 EWC46005.1 - 0.0074 16.2 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 F-box-like TFIIF_beta_N PF17683.1 EWC46006.1 - 1.8e-30 106.4 0.4 2.1e-29 102.9 0.4 2.3 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 EWC46006.1 - 8.5e-30 102.7 0.2 1.5e-29 101.9 0.2 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 EWC46006.1 - 0.00072 20.4 1.1 0.001 19.9 0.2 1.8 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Ribosomal_L21p PF00829.21 EWC46007.1 - 9e-08 32.3 0.0 2.3e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 Ribosomal prokaryotic L21 protein Ribosomal_S8e PF01201.22 EWC46008.1 - 3.7e-47 159.9 0.7 5.1e-47 159.5 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e UQ_con PF00179.26 EWC46009.1 - 3e-09 36.7 1.7 7.1e-09 35.4 0.0 2.3 3 0 0 3 3 3 1 Ubiquitin-conjugating enzyme UQ_con PF00179.26 EWC46010.1 - 6e-06 25.9 0.0 7e-06 25.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RhoGAP PF00620.27 EWC46011.1 - 2e-36 125.1 0.0 4.9e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EWC46011.1 - 1.8e-29 101.8 41.9 1.3e-11 44.5 7.8 5.2 5 0 0 5 5 5 4 LIM domain ORC3_N PF07034.11 EWC46013.1 - 4.1e-49 167.5 1.3 3.4e-47 161.2 0.3 2.6 2 1 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EWC46013.1 - 3e-17 63.0 0.0 7.8e-17 61.7 0.0 1.7 2 0 0 2 2 2 1 Origin recognition complex winged helix C-terminal Xpo1 PF08389.12 EWC46013.1 - 0.026 14.6 1.5 12 5.9 0.0 3.7 3 1 0 3 3 3 0 Exportin 1-like protein Syntaxin_2 PF14523.6 EWC46013.1 - 0.16 12.4 7.5 1 9.8 0.2 3.2 3 0 0 3 3 3 0 Syntaxin-like protein DUF4611 PF15387.6 EWC46013.1 - 0.71 10.1 3.9 9.5 6.5 1.6 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Peptidase_M43 PF05572.13 EWC46014.1 - 6.8e-14 52.0 0.0 1.1e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 EWC46014.1 - 0.00022 21.7 0.0 0.00058 20.4 0.0 1.7 1 1 1 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EWC46014.1 - 0.00026 21.2 1.1 0.00073 19.7 1.1 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EWC46014.1 - 0.00047 19.9 0.1 0.00094 18.9 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EWC46014.1 - 0.0057 16.5 0.1 0.0095 15.8 0.0 1.4 1 1 0 1 1 1 1 Matrixin PepSY_2 PF13670.6 EWC46014.1 - 0.045 13.7 0.6 2 8.4 0.0 2.9 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain Peptidase_M66 PF10462.9 EWC46014.1 - 0.063 12.2 0.4 0.096 11.6 0.4 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_2 PF13574.6 EWC46014.1 - 0.089 12.7 1.1 0.13 12.1 0.9 1.4 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like NAAA-beta PF15508.6 EWC46016.1 - 2.9e-13 49.9 0.1 4.7e-13 49.2 0.1 1.4 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase NUDIX PF00293.28 EWC46017.1 - 6.1e-09 36.0 0.1 6e-08 32.8 0.0 2.4 2 1 0 2 2 2 1 NUDIX domain Mannosidase_ig PF17786.1 EWC46017.1 - 0.076 13.6 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Mannosidase Ig/CBM-like domain MgtE PF01769.16 EWC46018.1 - 0.009 16.4 2.2 0.013 15.8 2.2 1.2 1 0 0 1 1 1 1 Divalent cation transporter DUF2721 PF11026.8 EWC46018.1 - 0.033 14.1 1.1 0.048 13.5 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF4191 PF13829.6 EWC46018.1 - 0.089 12.1 1.0 0.11 11.8 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) MT0933_antitox PF14013.6 EWC46019.1 - 0.25 11.7 9.4 3.6 7.9 0.7 3.1 1 1 1 2 2 2 0 MT0933-like antitoxin protein PAN_1 PF00024.26 EWC46024.1 - 2.7e-06 27.3 2.2 0.014 15.3 0.1 2.2 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.6 EWC46024.1 - 0.0014 18.5 0.8 0.0014 18.5 0.8 2.5 2 1 0 2 2 2 1 PAN domain Levi_coat PF01819.17 EWC46025.1 - 0.011 15.7 0.1 0.41 10.7 0.0 2.2 2 0 0 2 2 2 0 Levivirus coat protein SE PF08491.10 EWC46027.1 - 8.9e-108 359.5 0.0 1.2e-107 359.1 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EWC46027.1 - 1.8e-13 50.5 0.0 2.5e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EWC46027.1 - 7.3e-09 35.7 3.5 0.00026 20.7 1.1 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EWC46027.1 - 7.4e-05 22.0 1.7 0.22 10.5 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.14 EWC46027.1 - 0.00072 18.5 0.0 0.4 9.5 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 EWC46027.1 - 0.0029 17.8 0.4 0.006 16.8 0.4 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EWC46027.1 - 0.013 15.1 0.2 0.023 14.3 0.2 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 EWC46027.1 - 0.017 14.4 0.0 1.6 7.9 0.1 2.2 2 0 0 2 2 2 0 Thi4 family 3HCDH_N PF02737.18 EWC46027.1 - 0.023 14.6 0.1 0.046 13.6 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EWC46027.1 - 0.027 14.5 0.0 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_oxidored PF12831.7 EWC46027.1 - 0.031 13.6 0.1 0.043 13.2 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EWC46027.1 - 0.033 13.3 0.1 0.053 12.6 0.1 1.3 1 1 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EWC46027.1 - 0.062 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Rossmann-like PF10727.9 EWC46027.1 - 0.098 12.5 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Rossmann-like domain F420_oxidored PF03807.17 EWC46027.1 - 0.14 12.8 0.2 0.34 11.5 0.2 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HI0933_like PF03486.14 EWC46027.1 - 0.2 10.3 0.1 0.29 9.8 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein NUDIX PF00293.28 EWC46031.1 - 3.5e-17 62.7 0.0 1.3e-16 60.9 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain p450 PF00067.22 EWC46032.1 - 2.2e-79 267.4 0.0 2.7e-79 267.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ferric_reduct PF01794.19 EWC46036.1 - 6e-14 52.2 11.0 6e-14 52.2 11.0 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EWC46036.1 - 6.6e-12 45.5 0.0 8e-07 29.1 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_6 PF08030.12 EWC46036.1 - 8.5e-11 42.2 0.0 2.6e-10 40.6 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EWC46036.1 - 0.13 12.9 0.0 0.44 11.2 0.0 1.9 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain Fungal_lectin PF07938.12 EWC46037.1 - 7.5e-11 42.0 2.3 1.5e-08 34.4 2.0 2.4 1 1 0 1 1 1 1 Fungal fucose-specific lectin RNA_pol_Rpb5_C PF01191.19 EWC46042.1 - 6.7e-33 112.4 0.4 1.6e-32 111.2 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EWC46042.1 - 8.8e-30 103.1 0.0 1.4e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EWC46042.1 - 0.034 14.2 0.0 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Restriction endonuclease KN17_SH3 PF18131.1 EWC46042.1 - 0.15 12.2 0.1 0.49 10.6 0.1 1.8 2 0 0 2 2 2 0 KN17 SH3-like C-terminal domain AAA_3 PF07726.11 EWC46042.1 - 0.16 11.8 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Frankia_peptide PF14407.6 EWC46042.1 - 0.18 11.8 0.2 0.51 10.4 0.0 1.8 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. DUF3584 PF12128.8 EWC46043.1 - 0.0047 14.5 43.7 0.0086 13.7 25.0 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF3584) ABC_tran_CTD PF16326.5 EWC46043.1 - 0.015 15.6 2.6 0.015 15.6 2.6 6.0 4 3 1 6 6 6 0 ABC transporter C-terminal domain DUF948 PF06103.11 EWC46043.1 - 5.2 7.4 6.4 16 5.8 0.2 3.7 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.9 EWC46043.1 - 7.7 6.5 34.6 3.3 7.7 11.2 4.1 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DEAD PF00270.29 EWC46044.1 - 6.7e-43 146.5 0.0 9.7e-43 146.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC46044.1 - 3.5e-20 72.4 0.0 1.1e-19 70.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC46044.1 - 1.8e-05 24.8 0.0 2.7e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EWC46044.1 - 0.00012 21.3 0.0 0.00019 20.7 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 EWC46044.1 - 0.21 10.3 0.1 13 4.4 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 GTP1_OBG PF01018.22 EWC46045.1 - 4.9e-39 133.4 6.8 6.5e-30 103.8 3.7 2.6 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EWC46045.1 - 1.2e-22 80.1 0.0 3e-22 78.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EWC46045.1 - 3e-08 33.3 0.1 6.8e-08 32.2 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B 2OG-FeII_Oxy PF03171.20 EWC46047.1 - 2e-07 31.4 0.0 8e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.6 EWC46048.1 - 4.1e-30 105.4 0.0 5.6e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.12 EWC46048.1 - 0.0021 18.1 4.5 0.019 15.0 4.5 2.3 1 1 0 1 1 1 1 GRF zinc finger CUE PF02845.16 EWC46048.1 - 0.015 15.0 0.1 0.032 13.9 0.1 1.5 1 0 0 1 1 1 0 CUE domain WD40 PF00400.32 EWC46049.1 - 1.5e-14 54.1 15.0 0.0034 18.2 0.7 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC46049.1 - 7.7e-05 22.9 0.2 0.013 15.8 0.1 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Methyltransf_11 PF08241.12 EWC46050.1 - 9e-09 35.9 0.0 1.7e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC46050.1 - 8.5e-07 29.6 0.0 1.8e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC46050.1 - 0.0015 18.3 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC46050.1 - 0.028 15.2 0.0 0.072 13.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 EWC46051.1 - 4.7e-31 108.0 20.6 4.7e-31 108.0 20.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC46051.1 - 5.5e-07 28.8 2.4 5.5e-07 28.8 2.4 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter CDC45 PF02724.14 EWC46052.1 - 1.2e-190 635.1 21.2 9.7e-155 516.4 0.0 4.0 1 1 3 4 4 4 3 CDC45-like protein Cwf_Cwc_15 PF04889.12 EWC46052.1 - 3.2e-06 27.1 12.6 3.2e-06 27.1 12.6 2.2 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein RNA_pol_3_Rpc31 PF11705.8 EWC46052.1 - 2.8e-05 24.5 32.0 0.00037 20.8 20.7 2.4 2 0 0 2 2 2 2 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 EWC46052.1 - 0.00033 20.1 37.8 0.0041 16.5 16.8 2.1 2 0 0 2 2 2 2 BUD22 Tub_N PF16322.5 EWC46052.1 - 0.0012 19.3 18.7 0.0033 17.9 4.0 2.2 2 0 0 2 2 2 2 Tubby N-terminal CNDH2_C PF16858.5 EWC46052.1 - 0.0022 18.0 3.4 0.0022 18.0 3.4 2.2 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Nop14 PF04147.12 EWC46052.1 - 0.013 13.7 32.0 0.017 13.4 15.4 2.1 2 0 0 2 2 2 0 Nop14-like family SpoIIIAH PF12685.7 EWC46052.1 - 0.57 10.0 18.7 0.31 10.8 7.2 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein FAM60A PF15396.6 EWC46052.1 - 0.75 9.8 13.6 0.49 10.4 4.1 2.2 2 0 0 2 2 2 0 Protein Family FAM60A BSP_II PF05432.11 EWC46052.1 - 1 9.0 31.9 0.014 15.1 9.5 2.4 2 1 0 2 2 2 0 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 EWC46052.1 - 1.1 8.6 35.7 1.1 8.6 16.8 2.2 2 0 0 2 2 2 0 SDA1 Myc_N PF01056.18 EWC46052.1 - 1.1 9.0 13.1 0.041 13.8 1.2 2.2 2 0 0 2 2 2 0 Myc amino-terminal region DUF4604 PF15377.6 EWC46052.1 - 1.3 9.4 26.9 3.5 8.0 14.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) PNISR PF15996.5 EWC46052.1 - 1.4 9.1 19.7 0.94 9.7 7.4 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Pox_Ag35 PF03286.14 EWC46052.1 - 4.6 7.0 30.4 0.32 10.7 15.7 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PPP4R2 PF09184.11 EWC46052.1 - 5.1 6.6 37.2 0.15 11.6 16.1 2.1 2 0 0 2 2 2 0 PPP4R2 MCM_bind PF09739.9 EWC46052.1 - 5.2 5.4 10.4 1.5 7.2 2.9 2.1 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor Utp14 PF04615.13 EWC46052.1 - 7.5 5.0 29.0 4.9 5.6 4.5 2.1 2 0 0 2 2 2 0 Utp14 protein Egh16-like PF11327.8 EWC46053.1 - 9e-58 195.7 15.9 9e-58 195.7 15.9 1.8 2 1 0 2 2 2 1 Egh16-like virulence factor Collagen PF01391.18 EWC46053.1 - 0.0014 18.4 35.5 0.0014 18.4 35.5 4.9 2 1 1 3 3 3 1 Collagen triple helix repeat (20 copies) DUF780 PF05611.11 EWC46055.1 - 0.34 11.7 14.2 0.18 12.6 6.5 3.1 3 0 0 3 3 3 0 Caenorhabditis elegans protein of unknown function (DUF780) Mito_fiss_reg PF05308.11 EWC46056.1 - 2 8.4 8.1 3.9 7.5 8.1 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator Pkinase PF00069.25 EWC46058.1 - 5.7e-35 121.0 0.0 1.4e-34 119.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EWC46058.1 - 8.5e-22 77.6 0.0 1.2e-10 41.8 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EWC46058.1 - 3.7e-21 75.6 0.0 1.1e-20 74.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 EWC46058.1 - 3.2e-20 72.2 0.5 1.7e-06 28.4 0.0 5.1 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EWC46058.1 - 1.2e-17 63.8 0.1 5.6e-08 32.9 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC46058.1 - 4.3e-17 60.4 1.0 0.00038 20.7 0.0 6.3 7 1 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EWC46058.1 - 1.3e-12 47.6 0.5 1.5e-05 25.2 0.0 5.1 6 0 0 6 6 6 2 Ankyrin repeat Shigella_OspC PF06128.11 EWC46058.1 - 0.14 11.9 0.0 0.7 9.6 0.0 2.1 3 0 0 3 3 3 0 Shigella flexneri OspC protein DUF2997 PF11211.8 EWC46059.1 - 0.085 12.7 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) Fungal_trans PF04082.18 EWC46060.1 - 1.6e-26 92.9 0.0 2.5e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC46060.1 - 3.8e-10 39.7 10.3 6.2e-10 39.0 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RdRP PF05183.12 EWC46061.1 - 1.3e-173 578.8 0.0 1.6e-173 578.5 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Cation_efflux PF01545.21 EWC46061.1 - 3.2e-41 141.2 11.0 8.3e-41 139.9 11.0 1.7 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.22 EWC46061.1 - 6.4e-06 25.6 28.3 0.00026 20.3 8.6 2.9 3 0 0 3 3 3 2 ZIP Zinc transporter Ccdc124 PF06244.12 EWC46062.1 - 1.1e-25 90.7 7.1 1.8e-24 86.7 7.1 2.4 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 FAD_binding_8 PF08022.12 EWC46063.1 - 4.1e-14 52.6 0.0 7e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EWC46063.1 - 6.6e-13 48.9 11.4 6.6e-13 48.9 11.4 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EWC46063.1 - 6.8e-10 39.3 0.0 1.1e-05 25.5 0.0 2.4 2 0 0 2 2 2 2 Ferric reductase NAD binding domain TIMELESS_C PF05029.13 EWC46063.1 - 0.44 9.6 1.1 0.68 9.0 1.1 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region DUF2235 PF09994.9 EWC46064.1 - 1.8e-76 257.2 0.0 4e-74 249.6 0.0 2.0 2 0 0 2 2 2 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) Zn_clus PF00172.18 EWC46065.1 - 2.2e-08 34.1 9.7 4.1e-08 33.2 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EWC46065.1 - 0.0022 16.9 0.1 0.0031 16.4 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C3HC4_2 PF13923.6 EWC46066.1 - 0.23 11.3 1.9 1.6 8.6 0.4 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) LysM PF01476.20 EWC46069.1 - 1.1e-07 31.7 0.0 2.1e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 LysM domain Mito_carr PF00153.27 EWC46072.1 - 5.6e-60 199.3 5.6 4.5e-20 71.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EWC46072.1 - 0.0019 17.4 0.8 0.23 10.6 0.2 2.4 1 1 1 2 2 2 2 Gammaproteobacterial serine protease Kinesin PF00225.23 EWC46073.1 - 3.8e-112 374.5 0.4 8.2e-112 373.4 0.4 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EWC46073.1 - 1.9e-26 92.8 0.4 1.1e-25 90.4 0.1 2.5 2 0 0 2 2 2 1 Microtubule binding Methyltr_RsmB-F PF01189.17 EWC46074.1 - 5e-36 124.2 0.0 5.6e-27 94.7 0.0 3.4 2 1 1 3 3 3 3 16S rRNA methyltransferase RsmB/F HALZ PF02183.18 EWC46075.1 - 4.3e-05 23.6 10.0 0.038 14.2 1.6 3.6 3 0 0 3 3 3 2 Homeobox associated leucine zipper GAS PF13851.6 EWC46075.1 - 0.00041 19.8 20.3 0.025 13.9 7.5 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding YabA PF06156.13 EWC46075.1 - 0.0028 18.3 14.6 0.17 12.6 2.6 2.5 1 1 1 2 2 2 2 Initiation control protein YabA KASH_CCD PF14662.6 EWC46075.1 - 0.0041 17.0 21.5 1.2 9.0 12.4 2.5 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH WD40_alt PF14077.6 EWC46075.1 - 0.011 15.6 4.4 0.015 15.1 0.3 2.8 3 1 0 3 3 2 0 Alternative WD40 repeat motif DivIC PF04977.15 EWC46075.1 - 0.04 13.7 15.7 0.046 13.5 0.2 3.7 2 1 2 4 4 4 0 Septum formation initiator DUF4988 PF16378.5 EWC46075.1 - 0.058 13.1 2.6 0.43 10.2 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF4618 PF15397.6 EWC46075.1 - 0.09 12.2 16.4 1.1 8.6 16.4 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Filament PF00038.21 EWC46075.1 - 0.1 12.2 18.4 0.042 13.4 5.1 2.2 1 1 1 2 2 2 0 Intermediate filament protein DUF1664 PF07889.12 EWC46075.1 - 0.13 12.3 9.6 0.42 10.6 0.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EWC46075.1 - 0.14 11.0 22.3 0.74 8.6 22.3 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EWC46075.1 - 0.14 11.4 14.3 1.3 8.3 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Herpes_BLRF2 PF05812.12 EWC46075.1 - 0.18 11.9 7.4 0.19 11.9 0.2 2.6 2 1 0 2 2 2 0 Herpesvirus BLRF2 protein UPF0242 PF06785.11 EWC46075.1 - 0.31 11.1 22.2 0.055 13.6 7.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 EWC46075.1 - 0.4 11.1 10.5 0.13 12.7 0.7 3.4 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 EWC46075.1 - 0.41 11.0 11.2 0.54 10.6 0.2 3.4 3 1 0 3 3 3 0 TSC-22/dip/bun family bZIP_2 PF07716.15 EWC46075.1 - 0.61 10.2 0.1 0.61 10.2 0.1 4.2 2 1 1 4 4 4 0 Basic region leucine zipper SurA_N_2 PF13623.6 EWC46075.1 - 0.61 9.9 5.6 0.23 11.3 1.7 2.1 1 1 1 2 2 2 0 SurA N-terminal domain TMF_TATA_bd PF12325.8 EWC46075.1 - 0.65 10.2 20.7 0.54 10.5 4.8 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.21 EWC46075.1 - 0.66 10.1 20.0 0.36 11.0 0.5 3.6 3 1 1 4 4 4 0 bZIP transcription factor Prefoldin_2 PF01920.20 EWC46075.1 - 0.81 9.7 20.5 3.4 7.7 0.0 4.2 1 1 3 4 4 4 0 Prefoldin subunit Leu_zip PF15294.6 EWC46075.1 - 1 8.8 19.2 6.1 6.3 11.1 2.2 1 1 1 2 2 2 0 Leucine zipper CENP-F_leu_zip PF10473.9 EWC46075.1 - 1.1 9.3 24.6 7.2 6.6 7.8 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5595 PF18077.1 EWC46075.1 - 1.1 9.4 12.2 3.2 7.9 0.0 4.2 1 1 2 4 4 4 0 Domain of unknown function (DUF5595) LPP PF04728.13 EWC46075.1 - 1.2 9.6 5.4 1.5 9.3 0.1 3.0 3 0 0 3 3 2 0 Lipoprotein leucine-zipper Bacillus_HBL PF05791.11 EWC46075.1 - 1.3 8.9 8.1 1.7 8.4 0.4 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF3818 PF12825.7 EWC46075.1 - 1.3 8.0 9.5 5.4 5.9 9.5 1.8 1 1 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) TolA_bind_tri PF16331.5 EWC46075.1 - 1.4 9.0 13.6 2.4 8.3 0.1 3.8 1 1 3 4 4 4 0 TolA binding protein trimerisation APG6_N PF17675.1 EWC46075.1 - 1.9 9.0 27.0 9.7 6.7 9.6 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region ADIP PF11559.8 EWC46075.1 - 2.8 8.0 21.2 1.8 8.7 0.3 3.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Paralemmin PF03285.15 EWC46075.1 - 3 7.3 10.7 0.22 11.1 4.9 1.8 1 1 0 2 2 2 0 Paralemmin Trimer_CC PF08954.11 EWC46075.1 - 3.1 7.4 8.6 2.6 7.6 1.0 3.2 3 1 0 3 3 3 0 Trimerisation motif V_ATPase_I PF01496.19 EWC46075.1 - 3.8 5.3 12.2 0.099 10.5 4.2 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 EWC46075.1 - 5.1 7.2 24.5 4 7.5 6.6 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 EWC46075.1 - 6.8 5.7 19.5 0.84 8.7 3.4 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 IFP_35_N PF07334.13 EWC46075.1 - 9 6.5 12.2 0.21 11.7 0.5 3.2 2 1 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Herpes_BLRF2 PF05812.12 EWC46076.1 - 0.0019 18.3 0.9 0.0032 17.6 0.9 1.4 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein DivIC PF04977.15 EWC46076.1 - 0.048 13.4 6.0 0.15 11.9 6.0 1.7 1 1 0 1 1 1 0 Septum formation initiator Herpes_UL6 PF01763.16 EWC46076.1 - 0.06 11.9 0.3 0.067 11.7 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF4407 PF14362.6 EWC46076.1 - 0.067 12.5 1.2 0.071 12.5 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) JIP_LZII PF16471.5 EWC46076.1 - 0.13 12.4 4.8 0.25 11.5 4.8 1.6 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF3552 PF12072.8 EWC46076.1 - 0.13 11.6 7.0 0.17 11.3 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Spidroin_N PF16763.5 EWC46076.1 - 0.13 12.2 3.4 0.18 11.8 3.4 1.2 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term OmpH PF03938.14 EWC46076.1 - 0.15 12.4 5.0 0.23 11.8 5.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HIP1_clath_bdg PF16515.5 EWC46076.1 - 0.2 12.3 6.8 0.29 11.8 6.8 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 EWC46076.1 - 0.2 12.3 3.6 0.29 11.8 3.6 1.2 1 0 0 1 1 1 0 Initiation control protein YabA bZIP_2 PF07716.15 EWC46076.1 - 0.24 11.5 5.8 0.51 10.5 5.1 2.0 1 1 0 1 1 1 0 Basic region leucine zipper Spc7 PF08317.11 EWC46076.1 - 0.29 10.0 6.8 0.39 9.6 6.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Spc24 PF08286.11 EWC46076.1 - 0.49 10.7 5.0 0.71 10.2 5.0 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Prominin PF05478.11 EWC46076.1 - 0.6 8.0 1.8 0.69 7.8 1.8 1.0 1 0 0 1 1 1 0 Prominin Shugoshin_N PF07558.11 EWC46077.1 - 0.0063 16.4 10.8 3.1 7.7 0.9 5.3 4 1 1 5 5 5 2 Shugoshin N-terminal coiled-coil region HALZ PF02183.18 EWC46077.1 - 0.029 14.6 28.9 0.41 10.9 0.2 8.1 7 1 2 9 9 9 0 Homeobox associated leucine zipper GIT_CC PF16559.5 EWC46077.1 - 0.18 11.7 4.8 24 4.9 0.1 4.5 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor UPF0242 PF06785.11 EWC46077.1 - 0.31 11.1 21.9 6.8 6.8 5.3 3.0 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 EWC46077.1 - 0.32 11.1 32.5 1.1 9.4 1.9 7.8 5 1 4 9 9 9 0 bZIP transcription factor BLOC1_2 PF10046.9 EWC46077.1 - 1.5 9.2 11.9 0.17 12.2 0.9 3.3 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAS PF13851.6 EWC46077.1 - 2 7.7 20.3 0.68 9.2 3.2 3.4 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 EWC46077.1 - 3.7 7.6 9.4 2.1 8.3 2.0 2.8 2 1 1 3 3 3 0 Laminin Domain II CCDC-167 PF15188.6 EWC46077.1 - 8.1 6.9 11.5 5.8 7.3 1.1 3.6 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 DUF2514 PF10721.9 EWC46077.1 - 8.3 6.4 19.0 7.6 6.5 4.7 3.6 3 2 0 3 3 3 0 Protein of unknown function (DUF2514) CAP_N PF01213.19 EWC46078.1 - 0.01 15.4 2.8 0.016 14.7 2.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CytochromB561_N PF09786.9 EWC46078.1 - 0.52 9.2 4.2 0.74 8.7 4.2 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Abhydrolase_4 PF08386.10 EWC46079.1 - 8.5e-17 61.2 0.0 1.6e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 EWC46079.1 - 2.5e-12 47.0 0.0 2.9e-10 40.2 0.0 2.7 2 1 0 2 2 2 2 alpha/beta hydrolase fold Amidohydro_1 PF01979.20 EWC46080.1 - 6.8e-28 98.0 1.3 1.3e-26 93.7 1.3 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EWC46080.1 - 4e-14 53.0 0.4 7e-09 35.7 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family Imm21 PF15589.6 EWC46080.1 - 0.083 12.9 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 21 TED_complement PF07678.14 EWC46081.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 A-macroglobulin TED domain UPF0122 PF04297.14 EWC46082.1 - 0.15 12.4 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like F-box-like PF12937.7 EWC46083.1 - 2.7e-05 24.0 0.3 7.1e-05 22.6 0.3 1.8 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EWC46083.1 - 0.0027 17.6 0.0 0.007 16.2 0.0 1.6 1 0 0 1 1 1 1 F-box PRANC PF09372.10 EWC46083.1 - 0.028 14.7 0.1 0.074 13.4 0.1 1.7 1 0 0 1 1 1 0 PRANC domain UQ_con PF00179.26 EWC46085.1 - 4.7e-32 110.6 0.1 6.4e-32 110.1 0.1 1.2 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Sas10_Utp3 PF04000.15 EWC46086.1 - 7.9e-11 42.4 1.9 8.5e-11 42.3 0.1 2.0 2 0 0 2 2 2 1 Sas10/Utp3/C1D family DUF913 PF06025.12 EWC46086.1 - 0.05 12.6 1.0 0.075 12.0 1.0 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2637 PF10935.8 EWC46086.1 - 0.094 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) Nop14 PF04147.12 EWC46086.1 - 0.13 10.5 11.5 0.2 9.8 11.5 1.3 1 0 0 1 1 1 0 Nop14-like family Astro_capsid_p PF12226.8 EWC46086.1 - 0.49 9.5 11.6 0.79 8.8 11.6 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RRN3 PF05327.11 EWC46086.1 - 3.6 6.0 7.0 5.4 5.4 7.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Rhodanese PF00581.20 EWC46087.1 - 5.4e-11 43.0 0.0 9.4e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain SUIM_assoc PF16619.5 EWC46088.1 - 0.51 10.4 3.6 0.68 10.0 0.9 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-Di19 PF05605.12 EWC46089.1 - 6.6e-05 23.1 0.5 6.6e-05 23.1 0.5 2.3 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_aberr PF17017.5 EWC46089.1 - 7.5e-05 22.9 0.0 0.00018 21.7 0.0 1.6 1 0 0 1 1 1 1 Aberrant zinc-finger zf-C2H2 PF00096.26 EWC46089.1 - 0.00015 22.1 1.3 0.00015 22.1 1.3 3.3 4 0 0 4 4 2 1 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 EWC46089.1 - 0.0011 18.7 0.3 0.0011 18.7 0.3 2.9 3 0 0 3 3 2 2 C2H2-type zinc-finger domain FOXP-CC PF16159.5 EWC46089.1 - 0.0077 16.8 2.5 25 5.6 0.1 3.7 2 1 1 3 3 3 0 FOXP coiled-coil domain DUF4835 PF16119.5 EWC46089.1 - 0.012 14.7 0.2 0.019 14.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4835) zf-C2H2_4 PF13894.6 EWC46089.1 - 0.014 16.1 6.8 0.11 13.4 0.5 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 EWC46089.1 - 0.035 14.5 0.2 0.092 13.2 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-BED PF02892.15 EWC46089.1 - 0.089 12.8 4.7 0.58 10.2 0.2 2.7 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_jaz PF12171.8 EWC46089.1 - 0.12 12.7 0.7 0.31 11.4 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-RING_7 PF02591.15 EWC46089.1 - 0.13 12.4 2.0 4.8 7.5 0.0 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain zf-C2H2_9 PF16293.5 EWC46089.1 - 0.16 11.9 0.0 0.52 10.2 0.0 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) GAGA PF09237.11 EWC46089.1 - 0.21 11.4 5.1 0.74 9.7 0.0 3.2 4 0 0 4 4 4 0 GAGA factor Zn_clus PF00172.18 EWC46089.1 - 0.63 10.2 12.1 0.02 15.0 5.1 2.1 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4729 PF15866.5 EWC46089.1 - 2.4 7.4 6.0 25 4.1 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4729) Cupin_8 PF13621.6 EWC46090.1 - 4.8e-34 118.2 0.0 8.4e-34 117.4 0.0 1.3 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EWC46090.1 - 2.6e-07 30.4 0.0 1.3e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 EWC46090.1 - 0.0012 19.3 0.0 0.016 15.6 0.0 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 EWC46090.1 - 0.012 15.3 0.0 0.042 13.6 0.0 1.9 1 0 0 1 1 1 0 Cupin domain Thiolase_N PF00108.23 EWC46091.1 - 3e-87 292.3 0.8 5.5e-87 291.4 0.8 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EWC46091.1 - 8.2e-39 132.0 1.7 1.2e-38 131.5 0.3 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EWC46091.1 - 0.0046 16.6 3.1 0.021 14.4 0.5 2.7 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Glyco_hydro_16 PF00722.21 EWC46093.1 - 1.6e-08 34.2 0.1 2.5e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Bap31_Bap29_C PF18035.1 EWC46097.1 - 0.026 14.5 0.1 0.076 13.0 0.1 1.7 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain FliJ PF02050.16 EWC46097.1 - 1.8 8.8 5.7 1.6 8.9 3.7 1.9 2 0 0 2 2 2 0 Flagellar FliJ protein F-box-like PF12937.7 EWC46098.1 - 1.4e-05 24.8 0.0 6.3e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EWC46098.1 - 0.1 12.5 1.1 2.8 7.9 0.1 3.1 3 0 0 3 3 3 0 F-box domain nec1 PF10379.9 EWC46098.1 - 0.14 11.7 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Virulence protein nec1 UQ_con PF00179.26 EWC46099.1 - 8.3e-52 174.6 0.1 9.4e-52 174.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EWC46099.1 - 0.00054 19.7 0.0 0.00063 19.5 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EWC46099.1 - 0.069 13.4 0.0 0.12 12.6 0.1 1.5 1 1 0 1 1 1 0 RWD domain AMP-binding PF00501.28 EWC46101.1 - 2.2e-73 247.3 0.0 2.6e-73 247.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC46101.1 - 2.5e-17 63.6 0.0 8.2e-17 62.0 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EWC46101.1 - 3.8e-16 58.7 0.8 9.3e-16 57.5 0.3 1.9 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus TPR_2 PF07719.17 EWC46102.1 - 0.46 10.7 1.8 0.94 9.8 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Helo_like_N PF17111.5 EWC46103.1 - 1.2e-05 24.8 0.3 0.011 15.2 0.0 3.4 3 0 0 3 3 3 1 Fungal N-terminal domain of STAND proteins HsdM_N PF12161.8 EWC46103.1 - 0.0023 18.5 2.1 16 6.1 0.0 3.4 3 0 0 3 3 3 1 HsdM N-terminal domain BUD22 PF09073.10 EWC46103.1 - 0.044 13.1 6.7 0.065 12.6 6.7 1.2 1 0 0 1 1 1 0 BUD22 QRPTase_N PF02749.16 EWC46103.1 - 0.064 13.3 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, N-terminal domain Ribosomal_60s PF00428.19 EWC46103.1 - 0.2 12.3 8.4 0.62 10.7 8.4 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein Myc_N PF01056.18 EWC46103.1 - 0.46 10.3 4.8 0.97 9.3 4.8 1.5 1 0 0 1 1 1 0 Myc amino-terminal region DNA_pol_phi PF04931.13 EWC46103.1 - 0.65 8.0 10.6 1.2 7.1 10.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi MFAP1 PF06991.11 EWC46103.1 - 1.5 8.6 8.1 0.099 12.5 2.4 1.8 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing FYDLN_acid PF09538.10 EWC46103.1 - 2.1 9.1 10.6 3.1 8.5 9.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CDC27 PF09507.10 EWC46103.1 - 3 7.1 6.7 4.6 6.5 6.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 WRNPLPNID PF15017.6 EWC46103.1 - 8.6 7.3 17.4 34 5.4 0.2 2.6 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Ribonucleas_3_3 PF14622.6 EWC46105.1 - 0.0021 18.2 0.0 0.0032 17.6 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like EMP70 PF02990.16 EWC46106.1 - 1.7e-211 703.4 10.0 1.7e-211 703.4 10.0 1.3 2 0 0 2 2 2 1 Endomembrane protein 70 DUF4229 PF14012.6 EWC46106.1 - 1.3 9.2 5.7 1.7 8.8 0.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) CHAT PF12770.7 EWC46107.1 - 6.2e-37 127.6 0.4 1.3e-36 126.5 0.4 1.5 1 0 0 1 1 1 1 CHAT domain TPR_14 PF13428.6 EWC46107.1 - 8.4e-05 23.1 1.1 1.1 10.3 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat Peptidase_C50 PF03568.17 EWC46107.1 - 0.0082 15.3 0.1 0.024 13.7 0.1 1.8 1 1 0 1 1 1 1 Peptidase family C50 TPR_10 PF13374.6 EWC46107.1 - 0.057 13.3 9.0 1.2 9.1 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Arrestin_N PF00339.29 EWC46108.1 - 2.4e-06 27.7 0.1 1.8e-05 24.9 0.0 2.6 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain zf-TFIIIC PF12660.7 EWC46109.1 - 1.3e-22 79.6 0.2 3.4e-22 78.3 0.0 1.7 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex TFIIIC_delta PF12657.7 EWC46109.1 - 1.9e-05 24.7 0.0 6.4e-05 23.0 0.0 1.9 3 0 0 3 3 3 1 Transcription factor IIIC subunit delta N-term DZR PF12773.7 EWC46109.1 - 0.15 12.1 0.4 15 5.7 0.0 2.5 2 0 0 2 2 2 0 Double zinc ribbon MPLKIP PF15502.6 EWC46110.1 - 0.029 14.6 2.8 0.029 14.6 2.8 2.3 2 1 0 2 2 2 0 M-phase-specific PLK1-interacting protein KxDL PF10241.9 EWC46111.1 - 5.5e-29 100.3 0.6 7.9e-29 99.8 0.6 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein RNA_capsid PF03035.14 EWC46111.1 - 0.28 11.2 5.0 0.068 13.2 1.9 1.5 2 0 0 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein Mito_carr PF00153.27 EWC46112.1 - 0.00022 21.1 0.0 0.0065 16.4 0.0 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein Allantoicase PF03561.15 EWC46113.1 - 1.9e-92 306.8 0.0 1.2e-45 155.0 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat F5_F8_type_C PF00754.25 EWC46113.1 - 0.00092 19.3 0.0 0.011 15.9 0.0 2.4 2 0 0 2 2 2 1 F5/8 type C domain HupF_HypC PF01455.18 EWC46113.1 - 0.038 14.1 0.1 3.7 7.8 0.0 3.3 3 0 0 3 3 3 0 HupF/HypC family OTT_1508_deam PF14441.6 EWC46114.1 - 0.062 13.3 0.9 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 OTT_1508-like deaminase SCO1-SenC PF02630.14 EWC46114.1 - 0.13 12.1 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 SCO1/SenC EF-hand_1 PF00036.32 EWC46115.1 - 3.4e-24 82.6 8.9 2.4e-07 29.8 0.1 5.0 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EWC46115.1 - 4.6e-24 84.7 7.6 9.4e-16 58.0 0.7 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EWC46115.1 - 2.4e-23 80.0 4.6 3.4e-06 26.6 0.1 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EWC46115.1 - 1.7e-15 55.7 8.0 0.00018 20.9 0.4 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EWC46115.1 - 4.5e-10 39.2 12.1 0.00026 20.8 0.7 4.1 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 EWC46115.1 - 2.4e-06 27.4 5.3 0.046 13.7 0.1 3.8 1 1 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EWC46115.1 - 0.00069 19.9 0.4 0.016 15.5 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EWC46115.1 - 0.014 15.7 3.0 6.4 7.1 0.0 3.2 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.11 EWC46115.1 - 0.025 13.4 0.5 3.7 6.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_10 PF14788.6 EWC46115.1 - 0.16 11.9 1.3 12 5.8 0.0 3.6 3 1 0 3 3 3 0 EF hand HATPase_c PF02518.26 EWC46116.1 - 8.1e-26 90.7 0.0 1.8e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 EWC46116.1 - 1.5e-21 76.5 0.7 2e-11 44.0 0.2 3.6 3 0 0 3 3 3 3 PAS fold Response_reg PF00072.24 EWC46116.1 - 4.5e-19 68.7 0.0 7e-18 64.8 0.0 2.4 2 0 0 2 2 2 1 Response regulator receiver domain PAS PF00989.25 EWC46116.1 - 8e-17 61.3 0.0 4.3e-09 36.4 0.0 3.6 2 1 0 2 2 2 2 PAS fold HisKA PF00512.25 EWC46116.1 - 1.3e-15 57.2 0.0 4.5e-15 55.4 0.0 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EWC46116.1 - 2e-14 53.7 0.0 1.6e-06 28.3 0.0 3.0 2 1 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EWC46116.1 - 4.3e-10 39.8 0.4 7.2e-07 29.4 0.1 4.0 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.7 EWC46116.1 - 3e-05 23.9 0.0 0.0064 16.5 0.0 2.9 2 0 0 2 2 2 1 PAS domain Mo25 PF08569.11 EWC46117.1 - 2.2e-114 382.2 0.2 3e-114 381.8 0.2 1.2 1 0 0 1 1 1 1 Mo25-like HEAT_2 PF13646.6 EWC46117.1 - 0.012 16.0 0.1 0.066 13.6 0.0 2.3 2 0 0 2 2 2 0 HEAT repeats AAA PF00004.29 EWC46118.1 - 3.9e-52 176.1 0.0 1e-39 135.9 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC46118.1 - 2.5e-09 36.8 0.0 5.5e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EWC46118.1 - 9.3e-09 35.9 0.1 0.0038 17.6 0.0 3.0 3 1 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 EWC46118.1 - 1e-08 35.5 0.2 0.00014 22.1 0.0 4.0 3 2 1 4 4 4 1 AAA domain AAA_2 PF07724.14 EWC46118.1 - 5.2e-08 33.2 0.0 6e-06 26.5 0.0 3.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 EWC46118.1 - 7.2e-08 32.1 0.4 6.1e-06 25.9 0.1 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 EWC46118.1 - 7.6e-08 31.9 0.0 0.0047 16.2 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 EWC46118.1 - 2.7e-07 30.5 0.1 0.027 14.2 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EWC46118.1 - 4.7e-06 26.6 0.0 0.0015 18.5 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EWC46118.1 - 5.2e-06 26.7 0.0 0.16 12.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EWC46118.1 - 5.6e-06 26.9 0.1 0.015 15.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EWC46118.1 - 1.1e-05 25.0 0.2 0.0057 16.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EWC46118.1 - 1.1e-05 25.3 0.1 0.025 14.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EWC46118.1 - 1.8e-05 25.1 0.0 0.3 11.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EWC46118.1 - 5.9e-05 23.1 0.0 0.17 11.9 0.0 2.9 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 EWC46118.1 - 6.2e-05 23.3 0.0 0.054 13.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase TsaE PF02367.17 EWC46118.1 - 0.00014 21.8 0.0 0.079 13.0 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EWC46118.1 - 0.00069 19.6 2.7 16 5.3 0.1 4.1 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EWC46118.1 - 0.001 18.5 0.2 0.025 13.9 0.1 2.4 2 0 0 2 2 2 1 KaiC IstB_IS21 PF01695.17 EWC46118.1 - 0.0012 18.6 0.1 0.092 12.5 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_7 PF12775.7 EWC46118.1 - 0.0014 18.2 0.1 0.029 13.9 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 EWC46118.1 - 0.0014 18.6 0.8 6.1 6.7 0.0 3.6 4 0 0 4 4 4 0 NACHT domain TniB PF05621.11 EWC46118.1 - 0.0015 18.0 0.4 3.6 7.0 0.1 4.1 3 2 0 3 3 3 1 Bacterial TniB protein CDC48_N PF02359.18 EWC46118.1 - 0.0016 18.6 0.1 0.0064 16.6 0.0 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain Parvo_NS1 PF01057.17 EWC46118.1 - 0.0025 17.0 0.0 0.48 9.5 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EWC46118.1 - 0.0027 17.3 1.7 2.5 7.6 0.0 3.5 4 0 0 4 4 3 1 AAA domain NB-ARC PF00931.22 EWC46118.1 - 0.0037 16.5 0.0 1.5 7.9 0.1 2.5 2 0 0 2 2 2 1 NB-ARC domain Sigma54_activat PF00158.26 EWC46118.1 - 0.0058 16.3 0.0 0.61 9.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain KTI12 PF08433.10 EWC46118.1 - 0.0068 15.9 0.1 1.9 7.9 0.0 2.6 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_11 PF13086.6 EWC46118.1 - 0.0068 16.2 0.0 0.35 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EWC46118.1 - 0.013 16.0 0.3 0.056 14.0 0.1 2.1 2 0 0 2 2 1 0 ABC transporter PhoH PF02562.16 EWC46118.1 - 0.019 14.4 0.0 2.1 7.8 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_17 PF13207.6 EWC46118.1 - 0.023 15.1 0.1 9.2 6.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EWC46118.1 - 0.028 14.1 0.0 0.55 9.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_3 PF07726.11 EWC46118.1 - 0.053 13.4 0.0 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EWC46118.1 - 0.061 12.6 0.0 6 6.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin CPT PF07931.12 EWC46118.1 - 0.072 12.9 0.1 1.3 8.9 0.0 2.3 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 EWC46118.1 - 0.074 13.4 0.5 0.66 10.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain DUF2075 PF09848.9 EWC46118.1 - 0.077 12.2 0.2 0.65 9.2 0.1 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Hydin_ADK PF17213.3 EWC46118.1 - 0.087 13.1 0.3 1.4 9.2 0.1 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain IPT PF01745.16 EWC46118.1 - 0.16 11.3 0.1 1.9 7.8 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase ResIII PF04851.15 EWC46118.1 - 0.18 11.8 0.0 0.96 9.4 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Vps4_C PF09336.10 EWC46118.1 - 0.19 11.7 0.0 0.56 10.3 0.0 1.8 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain RasGEF PF00617.19 EWC46119.1 - 3.1e-43 148.0 0.0 5.4e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EWC46119.1 - 9.6e-13 48.3 0.0 1.9e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif Sigma70_ner PF04546.13 EWC46119.1 - 0.024 14.5 6.3 0.043 13.7 6.3 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region BUD22 PF09073.10 EWC46119.1 - 0.025 14.0 17.1 0.064 12.6 17.1 1.6 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EWC46119.1 - 0.065 11.4 11.1 0.1 10.8 11.1 1.1 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 EWC46119.1 - 0.12 12.4 4.9 0.25 11.4 4.9 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 EWC46119.1 - 0.13 11.9 3.4 0.31 10.7 3.4 1.6 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 EWC46119.1 - 0.24 11.2 4.4 0.76 9.5 4.4 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SDA1 PF05285.12 EWC46119.1 - 0.34 10.3 13.0 0.59 9.5 13.0 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EWC46119.1 - 2.7 6.2 12.1 4.6 5.4 12.1 1.3 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EWC46119.1 - 5.5 7.0 17.4 15 5.6 17.4 1.7 1 0 0 1 1 1 0 YL1 nuclear protein RRN3 PF05327.11 EWC46119.1 - 8.4 4.8 12.9 13 4.2 12.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 EWC46119.1 - 9.1 4.2 27.9 14 3.6 27.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi 5_nucleotid_C PF02872.18 EWC46120.1 - 4.5e-34 117.9 0.0 7e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EWC46120.1 - 1.1e-08 35.9 0.1 1.5e-08 35.4 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF601 PF04642.12 EWC46120.1 - 0.71 9.3 3.1 1.1 8.6 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 Methyltransf_25 PF13649.6 EWC46121.1 - 8.4e-13 48.8 0.0 5.2e-12 46.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EWC46121.1 - 3.7e-12 46.2 0.1 7e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EWC46121.1 - 7.8e-12 45.2 0.0 1.8e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC46121.1 - 1.2e-10 41.9 0.0 4.1e-10 40.2 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EWC46121.1 - 4.7e-07 29.8 0.1 8.6e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EWC46121.1 - 7.5e-07 28.9 0.1 1.6e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EWC46121.1 - 9.9e-06 25.5 0.0 1.8e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EWC46121.1 - 6.9e-05 22.3 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Met_10 PF02475.16 EWC46121.1 - 6.9e-05 22.7 0.5 0.0002 21.2 0.1 1.9 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_12 PF08242.12 EWC46121.1 - 0.00013 22.6 0.0 0.00059 20.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 EWC46121.1 - 0.00014 21.4 0.2 0.00022 20.7 0.2 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 EWC46121.1 - 0.00035 20.4 0.0 0.00071 19.4 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Ubie_methyltran PF01209.18 EWC46121.1 - 0.0012 18.2 0.1 0.0023 17.3 0.1 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EWC46121.1 - 0.0013 17.7 0.0 0.0026 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 EWC46121.1 - 0.0021 17.8 0.0 0.0038 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 EWC46121.1 - 0.0037 16.9 0.3 0.049 13.3 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical protein 95 FtsJ PF01728.19 EWC46121.1 - 0.004 17.3 0.1 0.011 15.9 0.0 1.8 2 0 0 2 2 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EWC46121.1 - 0.0078 15.5 0.0 0.022 14.0 0.0 1.7 2 0 0 2 2 2 1 O-methyltransferase domain zf-C2H2_2 PF12756.7 EWC46121.1 - 0.021 15.2 0.1 0.14 12.6 0.0 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Methyltransf_24 PF13578.6 EWC46121.1 - 0.055 14.5 0.0 0.15 13.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EWC46121.1 - 0.089 12.8 0.0 0.19 11.7 0.0 1.6 2 0 0 2 2 1 0 Methyltransferase domain Surfac_D-trimer PF09006.11 EWC46121.1 - 0.1 12.5 0.0 0.34 10.8 0.1 1.8 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation UPF0020 PF01170.18 EWC46121.1 - 0.11 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 tRNA_U5-meth_tr PF05958.11 EWC46121.1 - 0.14 11.1 0.0 0.25 10.3 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Peptidase_C13 PF01650.18 EWC46122.1 - 1.6e-43 149.1 0.1 1.9e-43 148.8 0.1 1.1 1 0 0 1 1 1 1 Peptidase C13 family Nif11 PF07862.11 EWC46122.1 - 0.047 14.0 0.1 0.23 11.8 0.0 2.1 2 0 0 2 2 2 0 Nif11 domain tRNA-synt_1 PF00133.22 EWC46123.1 - 1.4e-226 753.5 0.1 2.2e-226 752.8 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EWC46123.1 - 4.4e-24 85.2 0.0 1.2e-23 83.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EWC46123.1 - 6.3e-12 44.9 0.4 5.9e-05 22.0 0.1 3.7 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EWC46123.1 - 0.056 12.8 0.0 0.28 10.5 0.0 2.2 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain SH3_9 PF14604.6 EWC46124.1 - 1.2e-10 41.1 0.0 1.9e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EWC46124.1 - 3.3e-07 29.8 0.0 5.7e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EWC46124.1 - 0.00018 21.1 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DAP10 PF07213.11 EWC46124.1 - 0.049 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 DAP10 membrane protein Syndecan PF01034.20 EWC46124.1 - 0.054 13.4 0.0 0.093 12.7 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain ECSCR PF15820.5 EWC46124.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 EWC46124.1 - 0.14 13.0 0.0 0.25 12.2 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Coiled PF05710.12 EWC46124.1 - 0.44 11.4 4.9 0.95 10.3 4.9 1.5 1 0 0 1 1 1 0 Coiled coil MGC-24 PF05283.11 EWC46124.1 - 0.86 10.1 9.8 0.35 11.3 4.1 2.5 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin muHD PF10291.9 EWC46125.1 - 1.2e-64 218.3 0.0 1.7e-64 217.8 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EWC46125.1 - 1.4e-09 38.1 0.0 3.9e-09 36.7 0.0 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DEAD_2 PF06733.15 EWC46126.1 - 7.2e-57 191.8 0.2 1.3e-56 191.0 0.2 1.5 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 EWC46126.1 - 6.7e-47 159.6 2.8 2e-44 151.6 0.6 2.7 3 0 0 3 3 3 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EWC46126.1 - 5.1e-43 147.2 0.0 1.1e-42 146.1 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 EWC46126.1 - 0.0022 18.0 0.0 0.12 12.4 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EWC46126.1 - 0.015 15.1 0.0 1.5 8.6 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase YtxC PF08812.11 EWC46126.1 - 0.071 12.7 0.4 0.28 10.8 0.1 2.2 2 0 0 2 2 2 0 YtxC-like family zf-RING_2 PF13639.6 EWC46127.1 - 3.1e-08 33.8 6.6 6.2e-08 32.9 6.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EWC46127.1 - 1.4e-05 25.0 1.4 3.4e-05 23.8 1.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EWC46127.1 - 4.6e-05 23.6 4.8 0.00012 22.3 4.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 EWC46127.1 - 7e-05 22.9 3.5 0.00023 21.3 3.5 1.9 1 0 0 1 1 1 1 FANCL C-terminal domain HEAT_EZ PF13513.6 EWC46127.1 - 0.00018 22.0 1.1 0.16 12.5 0.0 4.0 3 0 0 3 3 2 1 HEAT-like repeat zf-C3HC4_2 PF13923.6 EWC46127.1 - 0.0024 17.7 5.7 0.0047 16.7 5.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC46127.1 - 0.01 15.7 5.9 0.02 14.8 5.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 EWC46127.1 - 0.015 15.6 5.3 0.037 14.3 5.3 1.7 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 EWC46127.1 - 0.015 15.4 6.3 0.031 14.4 6.3 1.5 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 EWC46127.1 - 0.083 12.5 3.7 0.17 11.5 3.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 EWC46127.1 - 0.61 10.0 4.6 0.38 10.7 2.0 2.0 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EWC46127.1 - 0.81 9.6 4.6 1.9 8.4 4.6 1.7 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_3 PF13920.6 EWC46127.1 - 1.5 8.7 4.3 3.4 7.6 4.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EWC46127.1 - 2.4 8.0 5.5 48 3.8 3.2 3.0 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Clat_adaptor_s PF01217.20 EWC46128.1 - 1.5e-56 190.3 1.8 1.7e-56 190.1 1.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ArAE_2_N PF10337.9 EWC46129.1 - 6.9e-22 78.1 5.8 4.7e-15 55.6 0.0 3.2 2 1 1 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EWC46129.1 - 2.1e-14 53.7 15.4 2.1e-14 53.7 15.4 2.9 3 0 0 3 3 3 1 Fusaric acid resistance protein-like ALMT PF11744.8 EWC46129.1 - 3e-05 23.1 17.6 0.0018 17.2 9.6 3.3 3 0 0 3 3 3 2 Aluminium activated malate transporter ArAE_2 PF10334.9 EWC46129.1 - 0.0087 15.9 0.4 0.017 15.0 0.4 1.4 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ArAE_1 PF06081.11 EWC46129.1 - 0.58 10.3 18.0 0.15 12.2 6.9 2.9 2 1 0 2 2 2 0 Aromatic acid exporter family member 1 DUF3302 PF11742.8 EWC46129.1 - 0.98 9.6 4.3 27 5.0 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) Ist1 PF03398.14 EWC46130.1 - 4.3e-60 202.3 6.1 5.4e-60 202.1 6.1 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Tam41_Mmp37 PF09139.11 EWC46131.1 - 2.1e-110 369.2 0.0 2.8e-110 368.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial SUN PF03856.13 EWC46132.1 - 1e-77 260.9 5.2 1.8e-77 260.2 5.2 1.4 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) SOG2 PF10428.9 EWC46132.1 - 0.24 10.6 30.3 0.37 9.9 30.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Presenilin PF01080.17 EWC46132.1 - 0.32 9.7 4.7 0.57 8.9 4.7 1.3 1 0 0 1 1 1 0 Presenilin MCM_bind PF09739.9 EWC46132.1 - 0.68 8.3 4.5 1 7.7 4.5 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Plasmodium_Vir PF05795.11 EWC46132.1 - 4.9 6.5 12.3 7.8 5.8 12.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein OPT PF03169.15 EWC46133.1 - 1.8e-140 469.5 17.3 2.1e-140 469.3 17.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein RasGAP PF00616.19 EWC46134.1 - 2.7e-34 118.7 2.6 2.8e-22 79.4 0.0 3.2 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EWC46134.1 - 1.8e-05 24.9 0.1 7e-05 23.0 0.1 2.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Iron_permease PF04120.12 EWC46135.1 - 0.3 10.9 0.1 0.3 10.9 0.1 2.5 1 1 2 3 3 3 0 Low affinity iron permease XRN_M PF17846.1 EWC46136.1 - 8.8e-139 463.3 0.1 3.3e-137 458.1 0.0 2.5 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 EWC46136.1 - 8.5e-101 336.4 0.0 1.3e-100 335.8 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 EWC46136.1 - 0.0017 18.4 1.6 0.0028 17.6 1.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EWC46136.1 - 0.0073 16.1 2.2 0.016 15.1 2.2 1.5 1 0 0 1 1 1 1 Zinc knuckle Uso1_p115_head PF04869.14 EWC46137.1 - 5e-105 351.1 1.4 9.3e-105 350.2 0.1 2.2 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EWC46137.1 - 2.4e-11 44.1 34.6 2.4e-11 44.1 34.6 3.4 1 1 1 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region Arm PF00514.23 EWC46137.1 - 0.15 12.2 3.6 2.5 8.3 0.1 4.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF3251 PF11622.8 EWC46137.1 - 8.6 6.0 8.6 1.6 8.4 0.6 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF3251) DHQ_synthase PF01761.20 EWC46138.1 - 6.5e-67 225.5 0.0 7.8e-67 225.2 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 EWC46138.1 - 3.9e-07 30.0 0.0 5.9e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Exonuc_VII_L PF02601.15 EWC46138.1 - 0.22 11.0 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit EPSP_synthase PF00275.20 EWC46139.1 - 9.1e-132 439.7 0.0 1.3e-131 439.2 0.0 1.1 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHquinase_I PF01487.15 EWC46139.1 - 5.3e-55 187.2 0.0 1.4e-54 185.8 0.0 1.7 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EWC46139.1 - 2.4e-34 118.8 0.0 3.9e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.11 EWC46139.1 - 6.3e-25 87.3 0.0 1.8e-24 85.8 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EWC46139.1 - 9.3e-06 25.3 0.1 1.9e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain DHQ_synthase PF01761.20 EWC46139.1 - 5.4e-05 22.5 0.0 0.00029 20.1 0.0 2.2 3 0 0 3 3 3 1 3-dehydroquinate synthase Shikimate_DH PF01488.20 EWC46139.1 - 9.6e-05 22.5 0.0 0.00027 21.0 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_18 PF13238.6 EWC46139.1 - 0.15 12.6 0.1 0.4 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain zf-C2H2 PF00096.26 EWC46140.1 - 1.3e-11 44.3 11.7 0.0033 17.8 0.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC46140.1 - 2.1e-06 28.1 9.7 0.22 12.4 1.4 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-Di19 PF05605.12 EWC46140.1 - 0.029 14.7 3.0 0.87 9.9 0.4 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding KKLCAg1 PF15204.6 EWC46140.1 - 2.9 8.0 4.6 5.4 7.2 0.0 2.5 2 0 0 2 2 2 0 Kita-kyushu lung cancer antigen 1 RNA_pol_Rpb1_5 PF04998.17 EWC46141.1 - 8.6e-87 290.9 0.0 1.5e-86 290.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EWC46141.1 - 2.4e-68 229.6 0.6 5.6e-68 228.4 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EWC46141.1 - 6.2e-34 117.2 0.0 1.8e-33 115.7 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EWC46141.1 - 3.5e-31 108.7 0.4 2.6e-25 89.4 0.0 3.0 3 0 0 3 3 3 2 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EWC46141.1 - 1.7e-19 69.7 0.1 9.4e-19 67.3 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 BUD22 PF09073.10 EWC46141.1 - 6.1 6.1 24.7 11 5.2 24.7 1.3 1 0 0 1 1 1 0 BUD22 PRP3 PF08572.10 EWC46142.1 - 5.7e-70 235.5 2.5 5.7e-70 235.5 2.5 1.9 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EWC46142.1 - 3.5e-45 153.7 0.6 3.5e-45 153.7 0.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Glyco_transf_22 PF03901.17 EWC46143.1 - 4.1e-55 187.7 15.0 5.2e-55 187.4 15.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Gar1 PF04410.14 EWC46144.1 - 2.5e-42 144.2 0.1 2.5e-42 144.2 0.1 1.7 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region Histone PF00125.24 EWC46145.1 - 1.3e-51 174.4 2.4 1.4e-51 174.2 2.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EWC46145.1 - 4.8e-06 26.9 0.0 7.2e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EWC46145.1 - 4.9e-05 23.4 0.5 7.7e-05 22.8 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EWC46145.1 - 7.9e-05 23.3 0.9 9.4e-05 23.0 0.9 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EWC46145.1 - 0.0045 17.2 0.5 0.0073 16.6 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EWC46145.1 - 0.034 14.2 0.2 0.055 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 EWC46146.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EWC46146.1 - 2.4e-05 24.7 0.1 2.8e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EWC46146.1 - 7.2e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EWC46146.1 - 0.0002 21.6 0.1 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EWC46146.1 - 0.0004 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EWC46146.1 - 0.0085 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EWC46146.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EWC46146.1 - 0.052 13.3 0.2 0.064 13.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 EWC46146.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region Thioredoxin_7 PF13899.6 EWC46147.1 - 2.7e-16 59.5 0.0 5.4e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EWC46147.1 - 7.7e-12 44.8 0.0 1.6e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EWC46147.1 - 3.3e-10 40.0 0.0 7.3e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 UBX domain UIM PF02809.20 EWC46147.1 - 0.012 15.5 0.0 0.012 15.5 0.0 4.3 5 0 0 5 5 5 0 Ubiquitin interaction motif TAP_C PF03943.13 EWC46147.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 TAP C-terminal domain FAM199X PF15814.5 EWC46147.1 - 0.21 10.6 3.5 0.37 9.8 3.5 1.4 1 0 0 1 1 1 0 Protein family FAM199X FTCD_C PF04961.12 EWC46147.1 - 2.9 7.6 7.5 7.8 6.2 7.5 1.7 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Zip PF02535.22 EWC46148.1 - 5.7e-57 193.4 2.4 6.7e-57 193.2 2.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter HAD_2 PF13419.6 EWC46149.1 - 3.7e-15 56.5 0.0 6.9e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EWC46149.1 - 2.4e-12 47.6 0.0 4.2e-10 40.3 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Methyltransf_25 PF13649.6 EWC46149.1 - 8.4e-11 42.4 0.0 2.7e-10 40.8 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 EWC46149.1 - 1.4e-10 41.1 0.0 2.1e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EWC46149.1 - 3.9e-09 36.5 0.0 7.1e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC46149.1 - 5.7e-08 33.3 0.0 2.3e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Hydrolase_like PF13242.6 EWC46149.1 - 8.3e-07 29.0 0.0 2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Methyltransf_18 PF12847.7 EWC46149.1 - 0.00013 21.9 0.1 0.00027 20.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC46149.1 - 0.00023 21.0 0.0 0.00077 19.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 EWC46149.1 - 0.0018 17.2 0.0 0.003 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) HAD PF12710.7 EWC46149.1 - 0.0019 18.6 0.0 0.0034 17.8 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Methyltransf_12 PF08242.12 EWC46149.1 - 0.0023 18.7 0.0 0.0057 17.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EWC46149.1 - 0.0055 16.3 0.1 0.0097 15.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 EWC46149.1 - 0.024 15.7 0.0 0.061 14.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 EWC46149.1 - 0.025 13.9 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 EWC46149.1 - 0.031 14.1 0.1 0.058 13.2 0.1 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase PGP_phosphatase PF09419.10 EWC46149.1 - 0.035 13.7 0.0 0.77 9.4 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Methyltransf_32 PF13679.6 EWC46149.1 - 0.083 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain CDC73_C PF05179.14 EWC46150.1 - 2e-38 131.5 0.1 2.2e-38 131.4 0.1 1.0 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal Polysacc_synt_4 PF04669.13 EWC46150.1 - 0.16 11.5 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis Sld5 PF05916.11 EWC46152.1 - 3.1e-21 75.9 0.3 5.3e-21 75.1 0.3 1.3 1 0 0 1 1 1 1 GINS complex protein HCNGP PF07818.13 EWC46153.1 - 5.9e-21 74.9 0.0 1.1e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 HCNGP-like protein Proteasome PF00227.26 EWC46154.1 - 2.2e-32 112.1 0.2 5e-32 110.9 0.2 1.6 1 1 0 1 1 1 1 Proteasome subunit zf-C3HC4_2 PF13923.6 EWC46155.1 - 4.3e-09 36.1 7.9 4.3e-09 36.1 7.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC46155.1 - 1.6e-08 34.7 8.0 1.6e-08 34.7 8.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EWC46155.1 - 1.3e-07 31.4 6.0 1.3e-07 31.4 6.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC46155.1 - 1.4e-07 31.3 9.3 1.4e-07 31.3 9.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC46155.1 - 1.6e-07 31.2 6.1 3.5e-07 30.1 6.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EWC46155.1 - 6.6e-07 29.4 9.2 6.6e-07 29.4 9.2 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EWC46155.1 - 7.4e-06 25.7 4.6 7.4e-06 25.7 4.6 1.6 2 0 0 2 2 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EWC46155.1 - 4.5e-05 23.2 5.5 4.5e-05 23.2 5.5 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EWC46155.1 - 0.00022 21.1 9.2 0.00022 21.1 9.2 2.3 3 1 0 3 3 2 1 zinc-RING finger domain LcrG PF07216.12 EWC46155.1 - 0.00031 20.6 0.1 0.00031 20.6 0.1 2.2 2 0 0 2 2 2 1 LcrG protein zf-RING_10 PF16685.5 EWC46155.1 - 0.00035 20.6 6.0 0.00083 19.5 6.0 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EWC46155.1 - 0.00054 20.2 7.6 0.00054 20.2 7.6 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ribbon_3 PF13248.6 EWC46155.1 - 0.0078 15.6 0.9 0.0078 15.6 0.9 2.9 3 0 0 3 3 2 1 zinc-ribbon domain NinF PF05810.12 EWC46155.1 - 0.038 13.9 0.1 0.13 12.2 0.1 1.9 1 0 0 1 1 1 0 NinF protein DZR PF12773.7 EWC46155.1 - 0.084 12.9 13.5 0.42 10.7 0.4 2.8 2 1 1 3 3 3 0 Double zinc ribbon IBR PF01485.21 EWC46155.1 - 2.5 8.4 15.1 5.1 7.4 2.0 2.7 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Zn_ribbon_17 PF17120.5 EWC46155.1 - 8.9 6.0 16.4 0.11 12.1 7.3 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Adaptin_N PF01602.20 EWC46156.1 - 1e-100 337.8 0.0 5.9e-100 335.3 0.0 2.0 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EWC46156.1 - 1.4e-15 57.7 0.8 1.2e-13 51.4 0.1 2.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC46156.1 - 2.2e-05 24.8 0.2 0.012 16.0 0.0 4.2 3 1 1 4 4 4 1 HEAT repeats HEAT PF02985.22 EWC46156.1 - 4.6e-05 23.3 0.8 15 6.2 0.0 5.1 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 EWC46156.1 - 0.0086 16.6 0.5 8.9 6.9 0.0 4.8 5 0 0 5 5 5 1 HEAT-like repeat RTP1_C1 PF10363.9 EWC46156.1 - 0.068 13.4 0.2 5.2 7.3 0.0 2.7 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 EWC46156.1 - 0.11 11.7 0.0 9.2 5.4 0.0 2.4 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Spc7 PF08317.11 EWC46156.1 - 0.38 9.6 2.0 0.65 8.8 2.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 EWC46156.1 - 0.47 11.1 2.0 1.4 9.6 1.0 2.3 2 0 0 2 2 2 0 SlyX Val_tRNA-synt_C PF10458.9 EWC46156.1 - 1.4 9.2 8.7 4.4 7.7 8.7 1.8 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Proteasome PF00227.26 EWC46157.1 - 1.2e-26 93.3 0.0 1.5e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Rad33 PF08730.10 EWC46157.1 - 0.012 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Rad33 TPR_11 PF13414.6 EWC46158.1 - 6.9e-11 41.7 5.1 0.00033 20.3 0.3 4.8 4 1 1 5 5 5 3 TPR repeat TPR_2 PF07719.17 EWC46158.1 - 2.9e-10 39.5 3.4 0.0026 17.7 0.6 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC46158.1 - 8e-08 31.8 7.1 0.00054 19.7 0.7 4.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EWC46158.1 - 2.7e-07 31.0 8.2 0.0038 17.7 0.0 4.3 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EWC46158.1 - 7.5e-07 29.1 5.4 0.00036 20.7 0.4 4.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC46158.1 - 7.2e-06 26.4 3.2 0.068 14.0 0.0 5.1 3 2 2 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC46158.1 - 0.00014 22.1 0.5 0.00055 20.1 0.3 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EWC46158.1 - 0.00041 20.8 5.8 8.7 7.2 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EWC46158.1 - 0.00044 20.2 2.6 0.26 11.6 0.6 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EWC46158.1 - 0.00096 19.3 0.1 0.0025 17.9 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EWC46158.1 - 0.0042 17.0 0.0 3.1 7.7 0.1 2.3 1 1 1 2 2 2 2 Virulence factor membrane-bound polymerase, C-terminal TPR_12 PF13424.6 EWC46158.1 - 0.0088 16.3 5.0 0.28 11.5 0.4 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.10 EWC46158.1 - 0.067 12.2 0.1 0.088 11.8 0.1 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF5588 PF17826.1 EWC46158.1 - 0.11 11.3 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5588) TPR_7 PF13176.6 EWC46158.1 - 0.24 11.5 1.5 1.2 9.3 0.5 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EWC46158.1 - 0.38 11.4 0.0 0.38 11.4 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Hormone_3 PF00159.18 EWC46158.1 - 0.41 10.7 1.7 1.2 9.2 0.1 2.5 3 0 0 3 3 2 0 Pancreatic hormone peptide Syja_N PF02383.18 EWC46159.1 - 1.4e-74 251.3 0.0 1.9e-74 250.8 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EWC46159.1 - 1.9e-11 44.0 0.1 3.5e-11 43.1 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2505 PF10698.9 EWC46161.1 - 0.03 14.5 0.4 0.066 13.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2505) Pkinase PF00069.25 EWC46163.1 - 9e-70 235.0 0.1 4e-69 232.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46163.1 - 1e-50 172.5 0.0 3.2e-50 170.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC46163.1 - 0.00025 19.9 4.6 0.011 14.6 0.0 2.4 2 0 0 2 2 2 2 Fungal protein kinase Ilm1 PF10311.9 EWC46164.1 - 7.1e-37 126.6 1.7 8.5e-37 126.3 1.7 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 Pkinase PF00069.25 EWC46165.1 - 8.9e-52 176.0 0.0 1.3e-51 175.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46165.1 - 2.8e-28 98.9 0.0 4.3e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC46165.1 - 2e-10 40.4 0.0 3.2e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EWC46165.1 - 5e-05 22.4 0.0 5e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EWC46165.1 - 0.059 12.7 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EWC46165.1 - 0.092 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 CHCH PF06747.13 EWC46166.1 - 0.0029 17.7 4.1 0.0075 16.4 3.9 1.8 1 1 1 2 2 2 1 CHCH domain Cmc1 PF08583.10 EWC46166.1 - 0.056 13.5 2.4 2.1 8.4 0.3 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like MTCP1 PF08991.10 EWC46166.1 - 0.062 13.5 1.0 0.12 12.7 1.0 1.4 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type NatB_MDM20 PF09797.9 EWC46167.1 - 1.3e-92 310.7 0.0 1.9e-92 310.1 0.0 1.3 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit DUF5091 PF17012.5 EWC46167.1 - 0.037 14.3 0.4 0.22 11.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5091) Fungal_trans_2 PF11951.8 EWC46168.1 - 3.4e-21 75.5 1.8 1.7e-11 43.6 0.3 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC46168.1 - 0.017 15.2 1.4 0.033 14.3 1.4 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ecm29 PF13001.7 EWC46169.1 - 3.6e-122 408.6 0.7 3e-121 405.5 0.0 2.9 3 1 0 3 3 3 1 Proteasome stabiliser Vac14_Fab1_bd PF12755.7 EWC46169.1 - 1.5e-06 28.7 0.2 0.00034 21.2 0.1 4.4 3 2 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EWC46169.1 - 3.8e-06 27.3 3.7 0.49 10.9 0.1 7.8 8 1 1 9 9 9 1 HEAT-like repeat CLASP_N PF12348.8 EWC46169.1 - 0.0002 21.0 1.0 0.34 10.4 0.1 4.9 4 1 1 5 5 5 1 CLASP N terminal HEAT PF02985.22 EWC46169.1 - 0.001 19.1 13.6 3.4 8.2 0.0 9.5 11 0 0 11 11 11 1 HEAT repeat VHS PF00790.19 EWC46169.1 - 0.072 12.9 0.0 0.4 10.5 0.0 2.4 1 0 0 1 1 1 0 VHS domain Tox-GHH PF15636.6 EWC46169.1 - 0.092 12.7 0.0 0.31 11.0 0.0 1.9 1 0 0 1 1 1 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin ADH_N PF08240.12 EWC46170.1 - 3.7e-30 104.0 2.0 6e-30 103.3 2.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC46170.1 - 3.7e-15 56.0 0.0 5.9e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EWC46170.1 - 6.4e-05 22.8 0.2 0.0002 21.2 0.2 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated CIAPIN1 PF05093.13 EWC46170.1 - 0.085 13.4 0.5 0.16 12.5 0.5 1.4 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis ADH_zinc_N_2 PF13602.6 EWC46170.1 - 0.087 13.9 0.0 0.17 12.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase zf-H2C2_2 PF13465.6 EWC46171.1 - 2.2e-13 50.0 15.0 2.3e-07 30.9 1.3 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 EWC46171.1 - 4.1e-08 33.2 25.5 0.013 15.9 9.4 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC46171.1 - 5.1e-05 23.8 23.0 0.48 11.4 7.6 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EWC46171.1 - 0.0049 16.7 5.4 0.008 16.1 0.6 2.4 2 0 0 2 2 2 1 zinc-finger of a C2HC-type DUF1908 PF08926.11 EWC46171.1 - 0.0087 15.2 0.4 0.071 12.2 0.4 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1908) Zn-ribbon_8 PF09723.10 EWC46171.1 - 0.042 14.0 6.6 1.3 9.2 2.5 2.6 2 0 0 2 2 2 0 Zinc ribbon domain bZIP_1 PF00170.21 EWC46171.1 - 0.087 12.9 0.2 0.18 12.0 0.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor zf-C2H2_jaz PF12171.8 EWC46171.1 - 0.32 11.3 15.5 18 5.8 0.0 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EWC46171.1 - 0.34 10.7 0.1 0.34 10.7 0.1 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type DZR PF12773.7 EWC46171.1 - 0.63 10.1 7.6 2.4 8.3 7.3 2.0 1 1 1 2 2 2 0 Double zinc ribbon C1_4 PF07975.12 EWC46171.1 - 1.2 9.4 5.9 2.6 8.4 0.9 2.3 1 1 0 2 2 2 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.12 EWC46171.1 - 1.8 8.6 5.5 11 6.0 5.5 2.0 1 1 0 1 1 1 0 zinc-ribbons LIM PF00412.22 EWC46171.1 - 2 8.7 8.1 15 5.9 8.8 1.9 1 1 1 2 2 2 0 LIM domain zf-LYAR PF08790.11 EWC46171.1 - 7.8 6.5 9.8 5 7.1 0.6 2.8 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.7 EWC46171.1 - 9.2 6.7 17.8 9 6.7 6.1 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) YTH PF04146.15 EWC46173.1 - 2.4e-60 203.2 0.0 4.1e-60 202.5 0.0 1.4 1 0 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 EWC46173.1 - 1.1e-06 28.4 0.0 2.7e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EWC46173.1 - 0.15 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 EWC46173.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif IGR PF09597.10 EWC46174.1 - 4.8e-22 77.8 0.2 7.9e-22 77.1 0.2 1.4 1 0 0 1 1 1 1 IGR protein motif Pkinase PF00069.25 EWC46175.1 - 6.4e-59 199.5 0.0 8e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46175.1 - 4.8e-31 108.0 0.0 6.2e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC46175.1 - 0.024 14.0 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 EWC46175.1 - 0.061 12.4 0.0 0.096 11.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kinesin PF00225.23 EWC46176.1 - 4.1e-96 321.8 0.0 9.4e-96 320.6 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EWC46176.1 - 1.9e-22 79.8 0.0 1.1e-21 77.3 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding PKcGMP_CC PF16808.5 EWC46176.1 - 0.01 15.6 3.0 0.11 12.4 0.2 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4407 PF14362.6 EWC46176.1 - 0.11 11.8 10.3 0.055 12.8 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DAGAT PF03982.13 EWC46177.1 - 7.8e-86 287.6 0.0 1.3e-51 175.3 0.0 2.1 2 0 0 2 2 2 2 Diacylglycerol acyltransferase Stk19 PF10494.9 EWC46178.1 - 4e-45 154.4 0.0 4.5e-45 154.3 0.0 1.0 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Ribonuc_L-PSP PF01042.21 EWC46178.1 - 0.035 14.1 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Endoribonuclease L-PSP MARVEL PF01284.23 EWC46179.1 - 3.7e-09 36.8 14.2 6.7e-08 32.7 12.3 2.0 2 0 0 2 2 2 1 Membrane-associating domain FA_desaturase PF00487.24 EWC46179.1 - 0.1 12.4 4.8 0.46 10.3 2.3 2.1 2 0 0 2 2 2 0 Fatty acid desaturase SARAF PF06682.12 EWC46179.1 - 0.59 9.7 1.2 1.1 8.8 0.0 2.0 2 1 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2070 PF09843.9 EWC46179.1 - 4 5.6 8.5 6.4 4.9 8.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FtsX PF02687.21 EWC46180.1 - 7.8 7.0 13.0 6.1 7.4 1.2 2.9 3 0 0 3 3 3 0 FtsX-like permease family SWIM PF04434.17 EWC46181.1 - 0.1 12.3 0.2 0.19 11.4 0.2 1.5 1 0 0 1 1 1 0 SWIM zinc finger ADH_N_2 PF16884.5 EWC46183.1 - 3.4e-25 88.0 0.0 6e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EWC46183.1 - 1.5e-21 76.8 0.0 2.5e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EWC46183.1 - 6.3e-10 40.2 0.1 1.3e-09 39.2 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF1015 PF06245.11 EWC46183.1 - 0.067 12.0 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) NUDIX PF00293.28 EWC46185.1 - 1.5e-15 57.4 0.0 2.1e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Kelch_5 PF13854.6 EWC46187.1 - 7.5e-12 45.0 2.0 1.7e-07 31.1 0.7 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 EWC46187.1 - 6e-06 26.0 0.0 5.7 7.1 0.0 4.7 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EWC46187.1 - 0.00062 20.0 3.4 4.9 7.6 0.2 5.3 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 EWC46187.1 - 0.0025 17.4 10.6 1.1 8.9 0.1 5.1 6 1 0 6 6 6 2 Kelch motif BatD PF13584.6 EWC46187.1 - 0.038 12.8 0.0 0.062 12.1 0.0 1.3 1 0 0 1 1 1 0 Oxygen tolerance Herpes_gE PF02480.16 EWC46187.1 - 0.061 12.1 0.0 0.088 11.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4381 PF14316.6 EWC46187.1 - 0.089 13.0 0.0 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF5385 PF17359.2 EWC46187.1 - 0.1 12.1 0.1 0.16 11.5 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) CcmD PF04995.14 EWC46187.1 - 0.4 10.8 2.0 0.79 9.9 2.0 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) CFEM PF05730.11 EWC46188.1 - 5.3e-08 32.8 6.2 1.1e-07 31.8 6.2 1.6 1 1 0 1 1 1 1 CFEM domain Fungal_trans_2 PF11951.8 EWC46189.1 - 1.1e-16 60.6 0.1 1.6e-16 60.1 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3 PF00933.21 EWC46190.1 - 1e-61 209.1 0.1 1.4e-61 208.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 EWC46190.1 - 4.5e-06 26.9 0.0 1.1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Glyco_hydro_3_C PF01915.22 EWC46190.1 - 0.00034 20.6 0.0 0.00067 19.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Xan_ur_permease PF00860.20 EWC46191.1 - 2.5e-25 89.0 34.7 1.6e-24 86.3 33.5 2.2 2 1 0 2 2 2 1 Permease family MFS_MOT1 PF16983.5 EWC46191.1 - 0.17 12.3 23.5 0.11 12.9 4.3 3.3 2 1 1 3 3 3 0 Molybdate transporter of MFS superfamily Methyltransf_11 PF08241.12 EWC46192.1 - 4.9e-07 30.3 0.0 9.2e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC46192.1 - 2.1e-05 24.4 0.0 3.9e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC46192.1 - 0.0034 18.1 0.0 0.0073 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC46192.1 - 0.01 15.2 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF1514 PF07438.11 EWC46193.1 - 0.33 10.9 1.9 8.5 6.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1514) DUF3621 PF12285.8 EWC46194.1 - 0.0043 17.4 0.3 0.015 15.6 0.3 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3621) Glu_synthase PF01645.17 EWC46194.1 - 0.18 10.9 0.0 0.25 10.4 0.0 1.1 1 0 0 1 1 1 0 Conserved region in glutamate synthase K_oxygenase PF13434.6 EWC46195.1 - 5.3e-11 42.2 0.0 2.3e-09 36.9 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EWC46195.1 - 2.8e-07 30.1 0.0 5.9e-07 29.0 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EWC46195.1 - 1.9e-06 26.6 0.0 3.3e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EWC46195.1 - 6.8e-06 25.5 0.0 3.8e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EWC46195.1 - 0.00066 19.0 0.3 0.0016 17.7 0.1 1.6 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EWC46195.1 - 0.011 15.9 0.0 0.034 14.4 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EWC46195.1 - 0.019 14.9 0.0 0.73 9.8 0.0 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding DAO PF01266.24 EWC46195.1 - 0.06 12.9 0.4 0.94 9.0 0.6 2.3 1 1 0 2 2 2 0 FAD dependent oxidoreductase Hexokinase_1 PF00349.21 EWC46196.1 - 5.1e-39 134.2 0.0 1.1e-38 133.2 0.0 1.5 2 0 0 2 2 2 1 Hexokinase Hexokinase_2 PF03727.16 EWC46196.1 - 1.2e-28 100.2 0.0 1.6e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Hexokinase NDT80_PhoG PF05224.12 EWC46197.1 - 1.8e-30 106.6 0.0 4.9e-30 105.1 0.0 1.8 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family VIR_N PF15912.5 EWC46197.1 - 4.4 6.8 8.6 17 4.9 4.1 2.4 2 0 0 2 2 2 0 Virilizer, N-terminal UNC-93 PF05978.16 EWC46198.1 - 3.5e-14 52.8 3.4 3.5e-14 52.8 3.4 2.5 2 1 1 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EWC46198.1 - 2.2e-13 49.9 29.0 2.2e-13 49.9 29.0 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EWC46198.1 - 0.00083 18.3 3.9 0.00083 18.3 3.9 2.0 2 0 0 2 2 2 1 MFS_1 like family DUF2569 PF10754.9 EWC46198.1 - 0.0082 16.6 2.9 0.87 10.0 0.1 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF2569) Glucosamine_iso PF01182.20 EWC46199.1 - 1.9e-13 50.9 0.0 2.9e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Sugar-bind PF04198.13 EWC46199.1 - 0.0054 15.9 0.1 0.0068 15.6 0.1 1.1 1 0 0 1 1 1 1 Putative sugar-binding domain DUF5642 PF18702.1 EWC46199.1 - 0.1 12.4 3.1 0.13 12.0 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5642) DUF4449 PF14613.6 EWC46200.1 - 2.6e-07 30.9 1.7 2.4e-06 27.8 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) Cep57_MT_bd PF06657.13 EWC46200.1 - 0.038 14.4 0.0 0.14 12.6 0.0 2.0 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF4404 PF14357.6 EWC46200.1 - 1.2 9.9 3.9 1.8 9.2 1.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF4360 PF14273.6 EWC46201.1 - 8.2e-65 218.0 2.3 9.4e-65 217.8 2.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) DUF237 PF03072.14 EWC46201.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF237) Fungal_trans PF04082.18 EWC46203.1 - 9.6e-60 201.9 0.1 1.4e-59 201.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EWC46203.1 - 0.00013 22.2 15.9 0.0019 18.6 3.2 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type AMP-binding PF00501.28 EWC46204.1 - 1.9e-154 514.3 0.0 1.4e-78 264.4 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EWC46204.1 - 5.4e-137 457.2 0.0 2.1e-39 135.5 0.0 6.1 6 1 0 6 6 6 5 Condensation domain PP-binding PF00550.25 EWC46204.1 - 4.7e-38 129.4 8.5 1.7e-08 34.7 0.1 5.9 6 0 0 6 6 6 4 Phosphopantetheine attachment site DUF229 PF02995.17 EWC46204.1 - 0.59 8.7 1.9 1.9 7.0 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF229) K_oxygenase PF13434.6 EWC46205.1 - 2.9e-114 381.8 0.0 3.5e-114 381.5 0.0 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EWC46205.1 - 8.3e-06 25.2 0.0 0.00011 21.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC46205.1 - 1.2e-05 25.3 0.5 0.00089 19.3 0.0 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding Asp_protease PF09668.10 EWC46206.1 - 5.2e-60 200.7 0.0 7.5e-60 200.2 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EWC46206.1 - 4.1e-23 81.8 0.1 1e-22 80.4 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EWC46206.1 - 1e-11 45.3 0.0 3e-11 43.8 0.0 1.9 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.23 EWC46206.1 - 7.3e-09 35.3 0.0 1.4e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EWC46206.1 - 3.8e-08 33.1 0.0 8.8e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain RVP_2 PF08284.11 EWC46206.1 - 0.00037 20.3 0.0 0.00078 19.2 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 EWC46206.1 - 0.0034 17.6 0.0 0.007 16.6 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RuvA_C PF07499.13 EWC46206.1 - 0.0087 16.5 0.7 0.027 14.9 0.2 2.0 2 0 0 2 2 2 1 RuvA, C-terminal domain UBA_4 PF14555.6 EWC46206.1 - 0.096 12.5 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 UBA-like domain RNA_pol_I_TF PF04090.12 EWC46207.1 - 9.2e-14 51.4 0.1 5.9e-13 48.8 0.2 2.1 2 1 0 2 2 2 1 RNA polymerase I specific initiation factor TAF1_subA PF14929.6 EWC46207.1 - 0.099 12.0 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A DUF4576 PF15144.6 EWC46207.1 - 0.14 12.1 0.0 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) BRO1 PF03097.18 EWC46208.1 - 1.9e-130 435.2 2.3 1.9e-130 435.2 2.3 1.9 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EWC46208.1 - 9.4e-71 238.5 21.4 1.9e-70 237.5 21.4 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Na_Ca_ex_C PF16494.5 EWC46208.1 - 0.03 14.8 1.3 0.12 12.8 1.3 2.0 1 0 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain CN_hydrolase PF00795.22 EWC46209.1 - 1.7e-45 155.5 0.0 3.1e-45 154.6 0.0 1.4 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Podoplanin PF05808.11 EWC46210.1 - 0.026 14.6 0.4 0.026 14.6 0.4 2.1 3 0 0 3 3 3 0 Podoplanin NUDIX_4 PF14815.6 EWC46210.1 - 0.19 11.7 1.4 0.35 10.9 1.4 1.4 1 0 0 1 1 1 0 NUDIX domain Yip1 PF04893.17 EWC46211.1 - 2e-11 43.9 14.2 2.6e-11 43.6 14.2 1.1 1 0 0 1 1 1 1 Yip1 domain Erg28 PF03694.13 EWC46212.1 - 2.7e-44 150.0 0.4 3.4e-44 149.7 0.4 1.1 1 0 0 1 1 1 1 Erg28 like protein TPR_19 PF14559.6 EWC46213.1 - 0.0079 16.7 1.1 0.035 14.6 0.3 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC46213.1 - 1.7 9.7 5.0 16 6.7 0.6 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ATG27 PF09451.10 EWC46215.1 - 1.1 9.0 2.1 1.5 8.6 2.1 1.1 1 0 0 1 1 1 0 Autophagy-related protein 27 Calcipressin PF04847.12 EWC46215.1 - 5 6.8 4.8 7.3 6.3 4.8 1.2 1 0 0 1 1 1 0 Calcipressin DUF3042 PF11240.8 EWC46216.1 - 0.39 10.8 0.9 1.2 9.3 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Apt1 PF10351.9 EWC46216.1 - 0.73 8.6 6.3 0.92 8.3 6.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Dicty_REP PF05086.12 EWC46216.1 - 2.2 6.1 3.3 2.9 5.8 3.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Gram_pos_anchor PF00746.21 EWC46216.1 - 4 7.5 7.6 0.16 11.9 0.6 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Macoilin PF09726.9 EWC46216.1 - 8.2 4.8 8.5 11 4.4 8.5 1.1 1 0 0 1 1 1 0 Macoilin family SH3_1 PF00018.28 EWC46217.1 - 9.5e-07 28.3 0.0 2.3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EWC46217.1 - 0.00026 20.6 0.0 0.0014 18.2 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EWC46217.1 - 0.00076 19.3 0.0 0.0026 17.6 0.0 1.9 1 1 0 1 1 1 1 Variant SH3 domain Pentapeptide_4 PF13599.6 EWC46217.1 - 0.17 12.1 0.2 0.86 9.8 0.1 2.1 1 1 1 2 2 2 0 Pentapeptide repeats (9 copies) Not1 PF04054.15 EWC46218.1 - 3.8e-131 437.4 0.1 1.1e-130 435.9 0.1 1.8 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EWC46218.1 - 1.3e-93 312.6 1.1 3.5e-93 311.1 1.1 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EWC46218.1 - 2.7e-54 183.1 4.0 4e-54 182.5 2.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EWC46218.1 - 1.6e-50 170.9 0.5 2.2e-49 167.2 0.0 3.0 3 1 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EWC46218.1 - 1.4e-28 99.9 0.2 1.4e-28 99.9 0.2 2.6 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat ETF_QO PF05187.13 EWC46220.1 - 1.1e-47 160.5 0.1 1.7e-47 159.8 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S NAD_binding_8 PF13450.6 EWC46220.1 - 2.2e-08 34.2 0.0 6e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EWC46220.1 - 4.2e-08 33.2 0.1 3.6e-05 23.5 0.1 2.8 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EWC46220.1 - 2.1e-07 30.4 1.2 0.00063 18.9 1.2 2.4 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EWC46220.1 - 4.8e-06 26.2 0.1 7.4e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EWC46220.1 - 6.6e-06 25.5 0.0 0.0011 18.3 0.1 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EWC46220.1 - 1.8e-05 24.1 0.0 4.2e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC46220.1 - 0.00062 19.8 0.2 0.0019 18.2 0.2 1.9 1 1 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EWC46220.1 - 0.001 18.4 0.2 0.002 17.5 0.2 1.6 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EWC46220.1 - 0.0018 17.0 0.5 0.0029 16.4 0.5 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EWC46220.1 - 0.0037 17.8 0.0 17 6.1 0.1 3.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EWC46220.1 - 0.0081 15.4 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EWC46220.1 - 0.034 13.0 0.1 0.093 11.6 0.1 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EWC46220.1 - 0.035 13.1 0.3 0.059 12.4 0.3 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Fer4_7 PF12838.7 EWC46220.1 - 0.047 14.3 0.5 0.13 12.9 0.5 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 EWC46220.1 - 0.061 13.4 0.7 0.18 12.0 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain Amino_oxidase PF01593.24 EWC46220.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase GIDA PF01134.22 EWC46220.1 - 0.15 11.1 0.3 0.21 10.6 0.3 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A TBP PF00352.21 EWC46221.1 - 1.5e-67 223.6 0.1 9e-33 112.1 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EWC46221.1 - 5e-05 23.3 0.0 0.22 11.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EWC46221.1 - 0.13 12.1 0.1 0.67 9.8 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) DAO PF01266.24 EWC46222.1 - 1e-37 130.6 4.3 1.9e-37 129.7 4.3 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EWC46222.1 - 3.2e-05 24.1 0.0 7e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EWC46222.1 - 0.00013 21.2 0.0 0.00062 19.0 0.0 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EWC46222.1 - 0.0016 17.8 0.0 1.5 8.0 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC46222.1 - 0.0032 17.5 0.1 0.086 12.8 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EWC46222.1 - 0.092 11.6 0.0 0.78 8.5 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase Methyltransf_23 PF13489.6 EWC46223.1 - 3.4e-24 85.5 0.0 5.9e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC46223.1 - 2.4e-09 37.7 0.0 4.6e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC46223.1 - 4.3e-09 37.0 0.0 1.1e-08 35.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC46223.1 - 1.1e-07 31.7 0.0 1.8e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC46223.1 - 5.7e-06 25.8 0.0 9e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EWC46223.1 - 0.00041 21.0 0.0 0.0014 19.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ribosomal_L9_N PF01281.19 EWC46223.1 - 0.2 11.2 0.6 0.75 9.4 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L9, N-terminal domain APC_15aa PF05972.11 EWC46224.1 - 0.12 12.7 0.5 0.59 10.5 0.5 2.2 1 0 0 1 1 1 0 APC 15 residue motif NST1 PF13945.6 EWC46225.1 - 2.1e-51 174.8 19.6 2.1e-51 174.8 19.6 5.5 5 2 1 6 6 6 2 Salt tolerance down-regulator Ras PF00071.22 EWC46226.1 - 6.1e-51 172.2 0.0 7.3e-51 172.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC46226.1 - 9.2e-23 80.7 0.0 1.4e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC46226.1 - 1.3e-08 34.4 0.0 2e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EWC46226.1 - 0.0095 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF1611_N PF17396.2 EWC46226.1 - 0.024 14.9 0.0 0.064 13.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_N) Rossmann-like domain PduV-EutP PF10662.9 EWC46226.1 - 0.038 13.7 0.0 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EWC46226.1 - 0.046 13.1 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EWC46226.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 EWC46226.1 - 0.21 11.3 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF1749 PF08538.10 EWC46227.1 - 7.5e-62 209.1 0.0 1.5e-61 208.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Ndc80_HEC PF03801.13 EWC46227.1 - 1.4e-44 151.4 0.0 3.2e-44 150.2 0.0 1.7 2 0 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 EWC46227.1 - 2.5e-06 27.5 0.8 2.5e-06 27.5 0.8 4.3 5 1 0 5 5 5 1 Domain of unknown function (DUF5595) Abhydrolase_6 PF12697.7 EWC46227.1 - 2.3e-05 25.1 0.1 4.8e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 EWC46227.1 - 0.0013 18.3 0.0 0.0041 16.7 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 EWC46227.1 - 0.0016 17.8 0.0 0.31 10.3 0.0 2.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 SHE3 PF17078.5 EWC46227.1 - 0.021 14.5 26.4 0.016 14.9 8.2 3.1 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Ser_hydrolase PF06821.13 EWC46227.1 - 0.027 14.3 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase DUF745 PF05335.13 EWC46227.1 - 0.3 10.8 20.5 0.019 14.7 4.2 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF745) FliD_N PF02465.18 EWC46227.1 - 2.9 8.7 14.7 0.88 10.3 2.9 3.9 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus NPV_P10 PF05531.12 EWC46227.1 - 4.6 7.8 11.9 6 7.4 0.4 3.4 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Exonuc_VII_L PF02601.15 EWC46227.1 - 4.6 6.7 17.5 1.4 8.4 4.6 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4250 PF14056.6 EWC46227.1 - 5 7.1 9.0 13 5.8 0.0 4.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4250) OmpH PF03938.14 EWC46227.1 - 5.3 7.4 34.6 0.36 11.1 5.7 3.8 3 1 1 4 4 4 0 Outer membrane protein (OmpH-like) TauD PF02668.16 EWC46228.1 - 1.1e-45 156.5 0.3 1.8e-45 155.8 0.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EWC46228.1 - 4.7e-18 65.6 2.1 6e-18 65.3 0.8 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 EWC46228.1 - 0.00068 18.8 0.0 0.022 13.9 0.0 2.1 2 0 0 2 2 2 1 CsiD TFR_dimer PF04253.15 EWC46229.1 - 6e-27 94.1 0.4 1.1e-26 93.3 0.4 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 EWC46229.1 - 1.1e-12 47.8 0.8 2.7e-12 46.5 0.8 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M28 PF04389.17 EWC46229.1 - 4.5e-06 26.5 0.0 2.1e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M28 Chordopox_A13L PF05961.11 EWC46229.1 - 0.0036 17.5 0.1 0.0093 16.2 0.1 1.7 1 0 0 1 1 1 1 Chordopoxvirus A13L protein FAD_binding_3 PF01494.19 EWC46231.1 - 5.6e-20 71.9 0.0 2.8e-19 69.6 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EWC46231.1 - 0.00011 21.3 0.0 0.0015 17.6 0.0 2.0 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.14 EWC46231.1 - 0.00014 21.2 0.0 0.00049 19.4 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EWC46231.1 - 0.00034 21.1 0.2 0.002 18.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC46231.1 - 0.0013 18.4 1.0 0.003 17.2 0.9 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EWC46231.1 - 0.011 14.7 0.5 5 5.9 0.5 2.9 3 0 0 3 3 3 0 Tryptophan halogenase HI0933_like PF03486.14 EWC46231.1 - 0.011 14.4 0.1 0.021 13.5 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 EWC46231.1 - 0.02 14.2 0.0 0.032 13.5 0.0 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EWC46231.1 - 0.022 13.8 0.2 0.04 13.0 0.2 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 EWC46231.1 - 0.023 14.6 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EWC46231.1 - 0.026 13.6 0.9 0.42 9.6 0.3 2.2 2 0 0 2 2 2 0 FAD binding domain Glu_dehyd_C PF16912.5 EWC46231.1 - 0.055 13.0 0.0 0.093 12.2 0.0 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus ApbA PF02558.16 EWC46231.1 - 0.097 12.3 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_8 PF13450.6 EWC46231.1 - 0.097 12.9 0.2 0.28 11.5 0.2 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain XdhC_C PF13478.6 EWC46231.1 - 0.11 13.0 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain Thi4 PF01946.17 EWC46231.1 - 0.12 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family UDPG_MGDP_dh_N PF03721.14 EWC46231.1 - 0.15 11.6 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TLD PF07534.16 EWC46232.1 - 8e-27 94.2 0.0 3.3e-26 92.2 0.0 1.9 1 1 0 1 1 1 1 TLD DUF1773 PF08593.10 EWC46232.1 - 3.3e-08 34.5 0.6 7.5e-08 33.3 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function DUF4473 PF14747.6 EWC46233.1 - 0.021 15.3 2.9 0.046 14.3 1.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4473) DUF2870 PF11069.8 EWC46233.1 - 0.11 12.9 0.5 0.16 12.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) NIBRIN_BRCT_II PF16508.5 EWC46234.1 - 9.4e-17 61.4 0.0 3.3e-16 59.7 0.0 2.0 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein Cas6 PF09559.10 EWC46234.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Cas6 Crispr PALP PF00291.25 EWC46235.1 - 1.2e-70 238.3 0.0 1.5e-70 237.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SIS PF01380.22 EWC46236.1 - 2.8e-59 198.6 0.1 8.3e-33 113.0 0.0 2.2 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EWC46236.1 - 5.7e-16 58.9 0.0 1.1e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EWC46236.1 - 2.7e-11 43.5 0.0 7.1e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EWC46236.1 - 0.0007 18.6 0.0 0.0018 17.2 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Peptidase_M19 PF01244.21 EWC46237.1 - 4.8e-106 354.5 0.0 5.7e-106 354.3 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.14 EWC46237.1 - 0.044 13.6 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 Amidohydrolase IF-2B PF01008.17 EWC46238.1 - 3.8e-59 200.2 1.5 4.3e-59 200.0 1.5 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DMRL_synthase PF00885.19 EWC46239.1 - 1.6e-53 180.4 0.0 2.4e-53 179.7 0.0 1.3 1 1 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Mitoc_mL59 PF18126.1 EWC46241.1 - 4.5e-38 130.5 6.2 5.3e-38 130.2 6.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Acyl_transf_3 PF01757.22 EWC46243.1 - 2.8e-28 99.0 34.2 4.6e-28 98.3 34.2 1.3 1 1 0 1 1 1 1 Acyltransferase family DUF418 PF04235.12 EWC46243.1 - 0.13 12.2 11.4 0.053 13.4 8.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF418) HSP70 PF00012.20 EWC46244.1 - 3.8e-09 35.3 0.0 6.4e-09 34.6 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein UQ_con PF00179.26 EWC46245.1 - 3.5e-30 104.5 0.0 6.2e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme VWA_2 PF13519.6 EWC46245.1 - 0.00024 21.7 0.0 0.00056 20.5 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain AA_permease PF00324.21 EWC46247.1 - 3.5e-63 213.9 33.8 4.3e-63 213.6 33.8 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EWC46247.1 - 1.5e-12 47.3 4.6 3.3e-08 33.0 0.0 3.7 4 0 0 4 4 4 3 Solute carrier family 12 AF-4 PF05110.13 EWC46247.1 - 3.5 5.6 8.4 5.1 5.0 8.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Opy2 PF09463.10 EWC46248.1 - 5.3 7.4 19.6 0.94 9.9 9.3 3.2 2 1 1 3 3 3 0 Opy2 protein DUF4231 PF14015.6 EWC46249.1 - 0.4 11.2 8.3 58 4.2 8.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) DUF4131 PF13567.6 EWC46249.1 - 0.53 9.9 4.2 1.2 8.8 3.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Tri3 PF07428.11 EWC46251.1 - 0.0035 16.3 0.0 0.5 9.2 0.0 2.2 1 1 1 2 2 2 2 15-O-acetyltransferase Tri3 adh_short PF00106.25 EWC46252.1 - 3.4e-40 137.6 0.0 4.6e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC46252.1 - 1.9e-28 99.6 0.0 2.5e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC46252.1 - 1.5e-12 47.8 0.0 3e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EWC46252.1 - 0.0001 21.9 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EWC46252.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain CMD PF02627.20 EWC46253.1 - 3.1e-05 23.9 0.0 8.9e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family adh_short_C2 PF13561.6 EWC46254.1 - 2e-44 151.9 0.7 1e-43 149.6 0.7 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EWC46254.1 - 1e-22 80.6 2.2 6.9e-22 77.9 2.2 1.9 1 1 0 1 1 1 1 short chain dehydrogenase Glyco_transf_22 PF03901.17 EWC46256.1 - 4.1e-78 263.5 15.0 5.1e-78 263.2 15.0 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Aminotran_5 PF00266.19 EWC46256.1 - 1.9e-45 155.4 0.0 3e-45 154.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EWC46256.1 - 2.3e-09 36.9 0.0 3.7e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EWC46256.1 - 0.00025 19.7 0.0 0.00039 19.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme B12-binding PF02310.19 EWC46256.1 - 0.035 14.1 0.0 0.085 12.9 0.0 1.6 1 0 0 1 1 1 0 B12 binding domain Glyco_transf_20 PF00982.21 EWC46257.1 - 2e-161 537.9 0.2 3.2e-161 537.2 0.0 1.4 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EWC46257.1 - 2.2e-42 144.8 0.0 3.5e-42 144.2 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase DUF4250 PF14056.6 EWC46257.1 - 0.039 13.9 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) Eisosome1 PF12757.7 EWC46258.1 - 3e-31 108.3 14.6 3e-31 108.3 14.6 4.6 4 1 1 5 5 5 1 Eisosome protein 1 zf-CRD PF17979.1 EWC46259.1 - 1.9e-14 54.1 0.0 1.9e-14 54.1 0.0 2.5 2 1 1 3 3 2 1 Cysteine rich domain with multizinc binding regions zf-C3HC4_2 PF13923.6 EWC46259.1 - 9.9e-10 38.1 12.3 9.9e-10 38.1 12.3 3.6 5 0 0 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC46259.1 - 4.3e-09 36.1 11.2 4.3e-09 36.1 11.2 3.9 4 1 1 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC46259.1 - 2.8e-07 30.8 12.5 2.8e-07 30.8 12.5 4.2 4 1 2 6 6 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EWC46259.1 - 2.5e-06 27.4 14.7 2e-05 24.5 12.7 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EWC46259.1 - 4.1e-06 26.6 11.7 4.1e-06 26.6 11.7 4.5 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC46259.1 - 5.9e-06 26.1 10.3 5.9e-06 26.1 10.3 3.3 4 1 0 4 4 3 1 zinc-RING finger domain zf-CCHH PF10283.9 EWC46259.1 - 1.3e-05 25.0 6.6 2.9e-05 23.9 6.6 1.6 1 0 0 1 1 1 1 PBZ domain zf-C3HC4_4 PF15227.6 EWC46259.1 - 3.4e-05 23.9 22.8 6.2e-05 23.1 12.9 3.8 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EWC46259.1 - 0.00018 21.3 8.3 0.00018 21.3 8.3 2.1 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EWC46259.1 - 0.001 19.2 8.1 0.001 19.2 8.1 2.9 3 0 0 3 3 3 1 zinc RING finger of MSL2 zf-Nse PF11789.8 EWC46259.1 - 0.076 12.8 4.3 0.24 11.2 4.3 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Casc1_N PF15927.5 EWC46259.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus SPOR PF05036.13 EWC46260.1 - 0.048 14.0 0.2 2.2 8.7 0.0 2.5 2 1 0 2 2 2 0 Sporulation related domain Cation_ATPase_C PF00689.21 EWC46262.1 - 7.5e-36 123.5 1.1 7.5e-36 123.5 1.1 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EWC46262.1 - 1.9e-35 122.0 2.8 2.8e-35 121.5 0.5 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EWC46262.1 - 1e-23 84.8 0.1 2.4e-11 44.3 0.0 3.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EWC46262.1 - 2.5e-15 56.3 0.0 5.6e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EWC46262.1 - 7.9e-13 47.9 0.0 1.7e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EWC46262.1 - 7.2e-06 25.9 1.2 1.5e-05 24.9 1.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EWC46262.1 - 0.012 16.0 0.0 0.17 12.3 0.0 2.6 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF2231 PF09990.9 EWC46262.1 - 0.29 11.6 1.7 1 9.8 1.7 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) DUF4149 PF13664.6 EWC46262.1 - 2.9 8.2 8.6 3.1 8.2 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) BaxI_1 PF12811.7 EWC46262.1 - 7.6 6.0 9.7 0.2 11.2 0.2 2.7 3 0 0 3 3 3 0 Bax inhibitor 1 like Autophagy_act_C PF03987.15 EWC46264.1 - 1.7e-11 44.5 1.4 2.9e-11 43.8 0.7 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain LRR_4 PF12799.7 EWC46265.1 - 0.0024 18.2 6.8 7.5 7.1 1.4 5.6 3 1 3 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EWC46265.1 - 0.015 15.8 8.9 85 4.3 0.1 6.4 5 0 0 5 5 5 0 Leucine Rich Repeat GATA PF00320.27 EWC46265.1 - 0.036 13.7 4.4 0.087 12.4 4.4 1.6 1 0 0 1 1 1 0 GATA zinc finger TFIIF_alpha PF05793.12 EWC46265.1 - 0.041 12.5 20.5 0.061 11.9 20.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SAM_Ste50p PF09235.10 EWC46265.1 - 0.05 13.8 5.8 5.8 7.2 0.9 3.4 3 0 0 3 3 3 0 Ste50p, sterile alpha motif SRP-alpha_N PF04086.13 EWC46265.1 - 0.13 12.2 18.6 0.2 11.6 18.6 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF5333 PF17267.2 EWC46265.1 - 0.16 12.1 1.1 0.59 10.3 0.4 2.4 3 0 0 3 3 3 0 Family of unknown function (DUF5333) PGA2 PF07543.12 EWC46265.1 - 0.18 11.7 17.0 1.8 8.5 9.7 2.7 2 0 0 2 2 2 0 Protein trafficking PGA2 LRR_6 PF13516.6 EWC46265.1 - 0.22 11.7 11.2 7.4 6.9 0.0 6.2 7 0 0 7 7 7 0 Leucine Rich repeat Pex14_N PF04695.13 EWC46265.1 - 1.3 9.7 7.6 0.055 14.1 1.8 1.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PBP1_TM PF14812.6 EWC46266.1 - 0.83 10.1 9.9 0.63 10.4 1.5 3.3 3 1 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SNF2_N PF00176.23 EWC46267.1 - 3.3e-57 193.8 0.0 1e-56 192.2 0.0 1.8 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC46267.1 - 5.8e-14 52.4 0.0 6.3e-12 45.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC46267.1 - 2.7e-10 40.5 0.2 9e-10 38.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EWC46267.1 - 4.2e-09 36.4 0.0 9.2e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.25 EWC46267.1 - 5.9e-06 26.0 8.1 5.9e-06 26.0 8.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC46267.1 - 6e-05 22.8 8.0 6e-05 22.8 8.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC46267.1 - 0.0021 18.1 5.5 0.0021 18.1 5.5 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EWC46267.1 - 0.0041 17.4 8.8 0.0041 17.4 8.8 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC46267.1 - 0.0053 16.6 7.9 0.0053 16.6 7.9 3.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.6 EWC46267.1 - 0.029 14.4 13.6 0.31 11.1 2.8 2.8 2 0 0 2 2 2 0 Transposase zinc-binding domain WW PF00397.26 EWC46268.1 - 5.4e-09 36.0 1.6 6.2e-09 35.8 0.2 1.9 2 0 0 2 2 2 1 WW domain WD40 PF00400.32 EWC46269.1 - 6.6e-13 48.9 10.0 0.002 18.9 0.1 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC46269.1 - 1.3e-05 25.4 0.0 0.38 11.1 0.0 3.7 3 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EWC46269.1 - 0.063 13.2 0.0 3.1 7.8 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 EWC46269.1 - 0.28 10.9 2.7 0.45 10.2 0.1 2.4 3 1 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain UCH PF00443.29 EWC46270.1 - 1.7e-25 90.0 0.0 3e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EWC46270.1 - 2.6e-13 50.1 0.4 6e-13 48.9 0.4 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein AAA PF00004.29 EWC46272.1 - 5.6e-13 49.5 0.1 2.3e-12 47.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC46272.1 - 2.7e-11 44.2 1.9 2.1e-10 41.3 0.3 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EWC46272.1 - 4.6e-11 43.1 0.0 1.1e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Cdc6_C PF09079.11 EWC46272.1 - 5.1e-06 26.4 0.0 1.8e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_30 PF13604.6 EWC46272.1 - 0.00026 20.8 0.6 0.00056 19.7 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_lid_10 PF17872.1 EWC46272.1 - 0.0003 20.9 0.1 0.00087 19.4 0.1 1.7 1 0 0 1 1 1 1 AAA lid domain T2SSE PF00437.20 EWC46272.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 EWC46272.1 - 0.02 14.5 2.2 2.7 7.5 0.1 3.2 3 1 1 4 4 4 0 AAA domain IstB_IS21 PF01695.17 EWC46272.1 - 0.036 13.8 0.1 0.49 10.1 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase_2 PF01637.18 EWC46272.1 - 0.044 13.7 0.0 0.13 12.1 0.0 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EWC46272.1 - 0.044 13.5 0.1 0.52 10.1 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_19 PF13245.6 EWC46272.1 - 0.057 13.8 0.9 0.49 10.7 0.9 2.3 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EWC46272.1 - 0.057 12.6 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 EWC46272.1 - 0.067 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 EWC46272.1 - 0.09 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase AAA_7 PF12775.7 EWC46272.1 - 0.099 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EWC46272.1 - 0.14 12.3 0.0 0.39 10.8 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EWC46272.1 - 0.15 12.5 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 EWC46272.1 - 0.15 11.2 0.1 0.25 10.5 0.1 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Ferric_reduct PF01794.19 EWC46273.1 - 0.47 10.6 8.2 0.47 10.6 6.7 1.9 1 1 0 1 1 1 0 Ferric reductase like transmembrane component Trep_Strep PF09605.10 EWC46273.1 - 4.6 7.2 8.6 1 9.3 3.8 2.1 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) AMP-binding PF00501.28 EWC46274.1 - 6.8e-69 232.5 0.0 8.7e-69 232.1 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC46274.1 - 1e-12 48.8 1.2 5.2e-12 46.6 0.9 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Proteasome PF00227.26 EWC46275.1 - 3.4e-39 134.3 0.0 3.9e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.32 EWC46276.1 - 1.8e-47 158.3 26.6 0.00018 22.3 0.0 12.6 13 0 0 13 13 13 9 WD domain, G-beta repeat Utp13 PF08625.11 EWC46276.1 - 1.4e-46 157.9 0.0 2.1e-46 157.3 0.0 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EWC46276.1 - 1.8e-16 60.2 3.1 0.32 11.3 0.0 8.4 5 2 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC46276.1 - 0.00012 20.9 0.0 0.59 8.7 0.0 3.4 4 0 0 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EWC46276.1 - 0.00028 20.0 0.4 0.027 13.4 0.0 3.7 3 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EWC46276.1 - 0.026 13.3 0.0 8.3 5.0 0.0 4.2 3 1 0 3 3 3 0 Nup133 N terminal like DUF1688 PF07958.11 EWC46277.1 - 1e-165 551.6 0.0 1.1e-165 551.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Q_salvage PF10343.9 EWC46277.1 - 0.18 11.3 0.0 7.5 6.0 0.0 2.1 2 0 0 2 2 2 0 Potential Queuosine, Q, salvage protein family TUG-UBL1 PF11470.8 EWC46278.1 - 1.3e-23 83.0 1.8 2.7e-23 81.9 0.1 2.4 2 0 0 2 2 2 1 TUG ubiquitin-like domain UBX PF00789.20 EWC46278.1 - 2.6e-07 30.8 0.0 4.8e-06 26.7 0.0 2.6 2 1 0 2 2 2 1 UBX domain RBD PF02196.15 EWC46278.1 - 0.0025 17.8 0.0 0.0051 16.9 0.0 1.5 1 0 0 1 1 1 1 Raf-like Ras-binding domain HlyIII PF03006.20 EWC46279.1 - 3.2e-59 200.4 17.2 3.9e-59 200.1 17.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3493 PF11998.8 EWC46279.1 - 0.033 14.3 0.5 0.14 12.4 0.5 2.0 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 RhoGAP PF00620.27 EWC46280.1 - 1.3e-13 51.1 0.0 3.2e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 EWC46280.1 - 3e-10 40.0 0.0 7e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EWC46280.1 - 2.7e-09 37.2 0.1 1e-08 35.4 0.0 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF5343 PF17278.2 EWC46280.1 - 0.019 15.0 0.5 0.041 14.0 0.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5343) Phage_TAC_8 PF10666.9 EWC46280.1 - 1.4 9.2 3.8 1.2 9.4 0.1 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Gp14 ()A118 SMAP PF15477.6 EWC46281.1 - 4.5e-07 30.7 3.7 4.5e-07 30.7 3.7 5.5 4 1 0 4 4 4 1 Small acidic protein family Peptidase_M16_C PF05193.21 EWC46282.1 - 4e-19 69.3 0.0 5.5e-14 52.6 0.0 3.3 3 1 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EWC46282.1 - 0.00047 20.2 0.0 0.0015 18.6 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) DNA_pol_E_B PF04042.16 EWC46283.1 - 4.9e-43 146.9 0.0 7.8e-43 146.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EWC46283.1 - 2e-42 144.3 0.0 4.6e-42 143.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Zw10 PF06248.13 EWC46283.1 - 2.4e-16 59.5 0.0 9.3e-16 57.5 0.0 1.8 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 EWC46283.1 - 0.015 15.0 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 C terminal SNF2_N PF00176.23 EWC46284.1 - 1.5e-57 194.9 0.0 2.5e-57 194.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.6 EWC46284.1 - 5.6e-08 32.5 8.8 1.2e-07 31.5 8.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC46284.1 - 3.2e-07 30.6 10.0 6.7e-07 29.5 10.0 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EWC46284.1 - 6.7e-07 29.1 6.3 1.5e-06 27.9 6.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EWC46284.1 - 8.8e-07 28.7 9.2 1.8e-06 27.7 9.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EWC46284.1 - 4.9e-06 26.7 6.5 1.9e-05 24.9 6.5 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EWC46284.1 - 1.1e-05 25.1 10.4 2.4e-05 24.1 10.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 EWC46284.1 - 0.00012 22.3 0.0 0.00027 21.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EWC46284.1 - 0.00013 21.8 8.3 0.00027 20.8 8.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EWC46284.1 - 0.013 15.5 7.6 0.027 14.5 7.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Cript PF10235.9 EWC46284.1 - 0.11 13.0 1.0 0.27 11.9 1.0 1.5 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Zn_ribbon_17 PF17120.5 EWC46284.1 - 0.9 9.2 6.5 1.7 8.4 6.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zinc-ribbons_6 PF07191.12 EWC46284.1 - 1.3 9.1 5.6 2.7 8.0 5.6 1.5 1 0 0 1 1 1 0 zinc-ribbons DZR PF12773.7 EWC46284.1 - 1.6 8.8 5.4 5 7.2 5.4 1.8 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_4 PF15227.6 EWC46284.1 - 9.5 6.5 9.5 19 5.5 9.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RAMP4 PF06624.12 EWC46285.1 - 4.2e-19 68.4 0.1 4.6e-19 68.2 0.1 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Polyketide_cyc PF03364.20 EWC46286.1 - 3.7e-21 75.7 0.0 4.8e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EWC46286.1 - 3.4e-06 27.4 0.7 3.7e-05 24.0 0.7 2.0 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport BatA PF07584.11 EWC46287.1 - 0.0043 17.4 0.7 0.051 13.9 0.0 2.2 2 0 0 2 2 2 1 Aerotolerance regulator N-terminal DUF1180 PF06679.12 EWC46287.1 - 0.012 16.1 0.7 0.022 15.2 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Mid2 PF04478.12 EWC46287.1 - 0.016 15.0 1.2 0.02 14.7 0.2 1.6 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor SKG6 PF08693.10 EWC46287.1 - 0.043 13.2 0.1 0.082 12.3 0.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 EWC46287.1 - 0.092 12.9 0.5 0.16 12.1 0.3 1.5 1 1 0 1 1 1 0 Podoplanin Taxilin PF09728.9 EWC46288.1 - 2.4e-93 312.7 66.0 3.5e-93 312.2 66.0 1.2 1 0 0 1 1 1 1 Myosin-like coiled-coil protein DUF1843 PF08898.10 EWC46288.1 - 1.4 9.5 5.6 1 9.9 1.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) GbpA_2 PF18416.1 EWC46289.1 - 0.11 12.8 0.1 0.26 11.6 0.1 1.5 1 0 0 1 1 1 0 N-acetylglucosamine binding protein domain 2 TFIIA PF03153.13 EWC46289.1 - 0.35 10.8 5.6 0.46 10.4 5.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Na_H_Exchanger PF00999.21 EWC46290.1 - 3.4e-37 128.2 25.8 1.2e-33 116.4 21.9 2.0 2 0 0 2 2 2 2 Sodium/hydrogen exchanger family M16C_assoc PF08367.11 EWC46291.1 - 7.2e-77 257.9 0.0 1.1e-76 257.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EWC46291.1 - 1e-32 113.6 0.0 3.5e-22 79.3 0.0 3.6 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EWC46291.1 - 4.2e-13 49.5 0.0 1.5e-11 44.5 0.0 2.8 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) F-box-like PF12937.7 EWC46292.1 - 0.0015 18.3 0.0 0.0037 17.1 0.0 1.7 1 0 0 1 1 1 1 F-box-like Formyl_trans_N PF00551.19 EWC46293.1 - 7.2e-44 149.7 0.0 9.3e-44 149.3 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase Ribosomal_L36e PF01158.18 EWC46294.1 - 4.2e-41 139.1 5.9 4.7e-41 139.0 5.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e PBS_linker_poly PF00427.21 EWC46294.1 - 0.11 12.6 0.3 0.11 12.5 0.3 1.1 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide DUF2207 PF09972.9 EWC46294.1 - 0.12 11.1 0.3 0.13 11.0 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ribosomal_L38e PF01781.18 EWC46295.1 - 2.3e-33 114.1 0.8 2.6e-33 113.9 0.8 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Cyclophil_like2 PF18050.1 EWC46295.1 - 0.12 12.3 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Cyclophilin-like family Acetyltransf_3 PF13302.7 EWC46296.1 - 7.9e-16 59.0 0.0 1.4e-15 58.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EWC46296.1 - 0.056 13.4 0.1 1.3 9.0 0.0 2.2 1 1 1 2 2 2 0 FR47-like protein Ipi1_N PF12333.8 EWC46298.1 - 6.1e-28 97.4 0.0 2.3e-27 95.6 0.0 2.0 1 0 0 1 1 1 1 Rix1 complex component involved in 60S ribosome maturation FAA_hydrolase_N PF09298.11 EWC46298.1 - 0.13 12.5 0.1 0.37 11.0 0.1 1.8 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal NACHT PF05729.12 EWC46299.1 - 3.8e-09 36.7 0.3 1.2e-08 35.0 0.0 2.1 2 0 0 2 2 2 1 NACHT domain NACHT_N PF17100.5 EWC46299.1 - 0.0012 18.7 0.0 0.0036 17.2 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase AAA_22 PF13401.6 EWC46299.1 - 0.004 17.4 0.0 0.022 15.1 0.0 2.3 1 0 0 1 1 1 1 AAA domain Ank_2 PF12796.7 EWC46299.1 - 0.0069 16.9 0.1 0.15 12.6 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Goodbye PF17109.5 EWC46299.1 - 0.011 16.2 0.1 0.05 14.1 0.0 2.1 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain AAA_33 PF13671.6 EWC46299.1 - 2 8.6 4.2 8.6 6.5 0.0 3.1 4 0 0 4 4 4 0 AAA domain BAR_2 PF10455.9 EWC46300.1 - 5.8e-51 173.3 0.0 1.2e-50 172.3 0.0 1.5 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EWC46300.1 - 3.2e-13 49.9 1.1 5.5e-12 45.8 0.3 2.6 2 1 0 2 2 2 1 BAR domain AMP-binding PF00501.28 EWC46301.1 - 1.6e-15 56.7 0.1 7.9e-07 28.0 0.0 2.5 2 1 0 2 2 2 2 AMP-binding enzyme Dopey_N PF04118.14 EWC46302.1 - 0.057 12.5 0.1 0.22 10.6 0.1 1.9 2 0 0 2 2 2 0 Dopey, N-terminal Cadherin_C PF01049.17 EWC46303.1 - 9 6.6 7.8 28 5.0 7.8 1.9 1 1 0 1 1 1 0 Cadherin cytoplasmic region p450 PF00067.22 EWC46304.1 - 9.1e-51 173.0 0.0 1.7e-50 172.2 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 ANAPC4_WD40 PF12894.7 EWC46305.1 - 0.0001 22.5 0.0 0.9 9.9 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EWC46305.1 - 0.0017 19.1 3.4 13 6.8 0.0 5.4 6 0 0 6 6 6 0 WD domain, G-beta repeat CDC45 PF02724.14 EWC46305.1 - 0.0051 15.2 13.7 0.007 14.7 13.7 1.1 1 0 0 1 1 1 1 CDC45-like protein TLP-20 PF06088.11 EWC46305.1 - 0.023 14.6 1.9 0.04 13.8 1.9 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) BUD22 PF09073.10 EWC46305.1 - 0.059 12.7 13.1 0.1 11.9 13.1 1.3 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 EWC46305.1 - 0.12 11.6 13.6 0.2 10.9 13.6 1.3 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 EWC46305.1 - 0.2 10.7 19.8 0.46 9.6 19.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TRAP_alpha PF03896.16 EWC46305.1 - 0.34 10.1 4.4 0.5 9.5 4.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.12 EWC46305.1 - 0.47 8.6 13.9 0.61 8.2 13.9 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 EWC46305.1 - 0.51 8.9 15.3 0.75 8.3 15.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sigma70_ner PF04546.13 EWC46305.1 - 0.89 9.4 8.1 1.4 8.8 8.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.10 EWC46305.1 - 0.9 10.0 17.1 2.2 8.7 17.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SDA1 PF05285.12 EWC46305.1 - 1.2 8.5 16.2 1.7 8.0 16.2 1.1 1 0 0 1 1 1 0 SDA1 FAM176 PF14851.6 EWC46305.1 - 1.8 8.2 7.2 5.2 6.7 7.2 1.8 1 1 0 1 1 1 0 FAM176 family Apt1 PF10351.9 EWC46305.1 - 2.4 6.9 7.4 3.5 6.4 7.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain YqfQ PF14181.6 EWC46305.1 - 4.4 7.5 9.2 11 6.1 8.7 1.9 1 1 0 1 1 1 0 YqfQ-like protein Pes-10 PF07149.11 EWC46305.1 - 4.8 6.1 6.1 6.3 5.7 6.1 1.1 1 0 0 1 1 1 0 Pes-10 RRN3 PF05327.11 EWC46305.1 - 4.9 5.6 8.9 6.6 5.1 8.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BTV_NS2 PF04514.12 EWC46305.1 - 6.5 5.5 8.9 9.7 4.9 8.9 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Roughex PF06020.11 EWC46305.1 - 7 5.6 8.2 11 5.0 8.2 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Diphthamide_syn PF01866.17 EWC46306.1 - 4.8e-73 246.2 0.0 6.3e-73 245.9 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Es2 PF09751.9 EWC46307.1 - 8.7e-118 394.8 8.0 1.1e-117 394.4 8.0 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 AMP-binding PF00501.28 EWC46308.1 - 9.4e-63 212.2 0.0 1.7e-62 211.4 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC46308.1 - 4.8e-09 37.1 0.3 1.3e-08 35.7 0.3 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DIE2_ALG10 PF04922.12 EWC46309.1 - 2.5e-109 366.2 22.1 2e-108 363.2 22.1 2.0 1 1 0 1 1 1 1 DIE2/ALG10 family FixS PF03597.15 EWC46310.1 - 0.64 9.8 5.4 1.1 9.1 5.4 1.3 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type TAF8_C PF10406.9 EWC46311.1 - 1.6e-12 47.7 0.8 1.6e-12 47.7 0.8 2.4 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EWC46311.1 - 4.8e-10 39.3 0.0 8.1e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TAF PF02969.17 EWC46311.1 - 0.0014 18.8 0.0 0.0047 17.1 0.0 1.9 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) SLD5_C PF16922.5 EWC46312.1 - 1.6e-16 60.3 0.9 2.4e-16 59.7 0.9 1.3 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EWC46312.1 - 1.4e-07 32.0 0.1 2.7e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 GINS complex protein Pyridoxal_deC PF00282.19 EWC46313.1 - 2.9e-102 342.2 0.0 4e-102 341.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain cwf21 PF08312.12 EWC46313.1 - 0.023 14.8 0.1 0.092 12.9 0.0 2.0 2 0 0 2 2 2 0 cwf21 domain Rad51 PF08423.11 EWC46315.1 - 3.8e-05 23.1 0.0 0.0084 15.4 0.0 2.3 2 0 0 2 2 2 2 Rad51 PSY3 PF16836.5 EWC46315.1 - 0.0019 17.8 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Shu complex component Psy3, DNA-binding description AAA_25 PF13481.6 EWC46315.1 - 0.014 15.0 0.0 0.051 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Mitochondr_Som1 PF11093.8 EWC46316.1 - 0.0095 15.9 0.3 0.031 14.3 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial export protein Som1 Ank_2 PF12796.7 EWC46317.1 - 4.3e-17 62.5 0.4 2.8e-08 34.2 0.1 3.7 2 1 3 5 5 5 3 Ankyrin repeats (3 copies) Ank PF00023.30 EWC46317.1 - 4.9e-15 55.2 1.1 0.003 18.0 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EWC46317.1 - 8.9e-13 48.5 1.8 0.00018 22.0 0.0 4.7 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC46317.1 - 4e-12 45.2 1.3 0.0029 18.0 0.0 6.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EWC46317.1 - 1.2e-09 38.2 0.3 0.017 15.4 0.0 4.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) HrpB1_HrpK PF09613.10 EWC46317.1 - 0.0041 16.7 0.5 0.0094 15.6 0.3 1.7 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_1 PF00515.28 EWC46317.1 - 0.024 14.4 0.3 0.077 12.9 0.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46317.1 - 0.025 14.7 2.5 0.22 11.7 0.5 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EWC46317.1 - 0.039 14.6 0.6 0.039 14.6 0.6 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EWC46317.1 - 0.32 11.0 2.2 0.6 10.1 1.3 1.9 2 1 0 2 2 2 0 Putative TPR-like repeat Fis1_TPR_C PF14853.6 EWC46317.1 - 0.48 10.5 4.6 0.39 10.8 1.2 2.2 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Apt1 PF10351.9 EWC46318.1 - 0.042 12.7 1.6 0.043 12.7 1.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Plasmodium_Vir PF05795.11 EWC46318.1 - 0.044 13.2 0.9 0.074 12.5 0.9 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein eRF1_1 PF03463.15 EWC46320.1 - 1.6e-52 176.9 0.0 2.6e-52 176.2 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 EWC46320.1 - 1.3e-27 96.7 0.0 2.1e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EWC46320.1 - 5e-21 75.3 0.1 1.2e-20 74.0 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 3 Diphthami_syn_2 PF01902.17 EWC46321.1 - 2.8e-31 108.8 0.1 1.1e-29 103.6 0.1 2.4 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EWC46321.1 - 5.2e-18 65.2 0.0 3.1e-08 33.7 0.0 3.2 2 1 0 2 2 2 2 Endoribonuclease L-PSP Asp PF00026.23 EWC46322.1 - 2.3e-12 47.0 0.0 5.6e-12 45.7 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease SLC3A2_N PF16028.5 EWC46323.1 - 6.3 6.4 6.8 15 5.2 1.0 3.3 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus Glyco_hydro_45 PF02015.16 EWC46324.1 - 1.7e-45 155.5 7.1 2.1e-45 155.2 7.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Thioredoxin PF00085.20 EWC46325.1 - 3.4e-34 116.9 0.0 5.6e-28 97.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EWC46325.1 - 2.3e-07 31.2 0.1 0.0026 18.2 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like domain HyaE PF07449.11 EWC46325.1 - 0.017 15.1 0.0 0.19 11.7 0.0 2.4 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE EspA PF03433.13 EWC46325.1 - 0.048 13.5 0.1 0.088 12.6 0.0 1.7 2 0 0 2 2 2 0 EspA-like secreted protein TraF PF13728.6 EWC46325.1 - 0.59 9.9 17.0 3 7.6 0.0 3.8 4 0 0 4 4 4 0 F plasmid transfer operon protein DUF3408 PF11888.8 EWC46325.1 - 1.3 9.1 12.9 0.2 11.8 8.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) RR_TM4-6 PF06459.12 EWC46325.1 - 7.6 6.3 10.4 14 5.5 10.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF846 PF05832.12 EWC46326.1 - 1.8e-49 167.3 6.2 2.2e-49 167.1 6.2 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) eIF-3_zeta PF05091.12 EWC46327.1 - 1.5e-201 670.9 0.0 1.9e-201 670.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 EWC46327.1 - 0.01 15.4 0.0 0.21 11.1 0.0 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus ChaC PF04752.12 EWC46328.1 - 2e-34 119.2 0.1 7.4e-34 117.3 0.1 1.6 1 1 0 1 1 1 1 ChaC-like protein RRM_1 PF00076.22 EWC46329.1 - 6.4e-23 80.4 0.0 8.3e-23 80.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC46329.1 - 0.00084 19.1 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EWC46329.1 - 0.001 19.1 0.0 0.0017 18.4 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif PAP_PilO PF06864.12 EWC46329.1 - 0.029 13.2 0.1 0.037 12.9 0.1 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) EF-hand_1 PF00036.32 EWC46330.1 - 3e-29 98.4 1.3 5.3e-07 28.7 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EWC46330.1 - 4.1e-25 88.0 0.8 2.3e-11 44.0 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EWC46330.1 - 7.6e-25 84.7 3.1 0.00012 21.8 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 EWC46330.1 - 1.9e-24 85.3 4.0 3.8e-09 36.3 0.3 5.1 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 EWC46330.1 - 2.8e-21 74.0 0.2 0.00015 21.1 0.0 4.4 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 EWC46330.1 - 0.059 13.7 0.0 2.2 8.6 0.0 2.9 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region GUN4 PF05419.12 EWC46330.1 - 0.12 12.4 0.0 0.37 10.9 0.0 1.7 2 0 0 2 2 2 0 GUN4-like EF-hand_4 PF12763.7 EWC46330.1 - 0.13 12.3 0.3 1.7 8.7 0.0 2.5 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.25 EWC46332.1 - 1.1e-61 208.5 0.0 1.6e-61 208.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46332.1 - 4.7e-29 101.5 0.0 7.6e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EWC46332.1 - 1.3e-14 54.3 0.2 1.4e-07 31.7 0.1 2.8 2 0 0 2 2 2 2 FHA domain Yop-YscD_cpl PF16697.5 EWC46332.1 - 1.6e-05 25.2 0.0 0.022 15.1 0.0 2.7 2 0 0 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain OspD PF03207.13 EWC46332.1 - 0.00029 20.3 0.2 0.00047 19.6 0.2 1.2 1 0 0 1 1 1 1 Borrelia outer surface protein D (OspD) Kinase-like PF14531.6 EWC46332.1 - 0.00057 19.3 0.0 0.0017 17.7 0.0 1.7 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EWC46332.1 - 0.0017 17.8 0.1 0.0034 16.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ribul_P_3_epim PF00834.19 EWC46333.1 - 5.3e-66 221.8 0.0 6.3e-66 221.6 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 EWC46333.1 - 0.00034 20.0 0.2 0.00046 19.6 0.2 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG OMPdecase PF00215.24 EWC46333.1 - 0.12 11.9 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family PG_binding_3 PF09374.10 EWC46333.1 - 0.2 11.9 0.1 0.46 10.8 0.1 1.6 1 0 0 1 1 1 0 Predicted Peptidoglycan domain Methyltransf_11 PF08241.12 EWC46335.1 - 7.2e-07 29.8 0.0 3.7e-06 27.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC46335.1 - 0.0024 18.5 0.0 2.5 8.9 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain TPR_1 PF00515.28 EWC46336.1 - 3.6e-25 86.7 6.6 2.6e-09 36.5 0.0 5.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46336.1 - 4.6e-24 82.5 5.7 1.3e-07 31.1 0.0 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EWC46336.1 - 2.3e-18 65.6 5.7 1.7e-08 34.0 0.0 5.0 4 1 1 5 5 5 3 TPR repeat TPR_8 PF13181.6 EWC46336.1 - 5.9e-16 57.3 0.8 6.8e-07 29.0 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EWC46336.1 - 1.5e-15 57.6 6.1 7.7e-06 26.5 0.0 4.8 2 2 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EWC46336.1 - 4.1e-15 55.2 2.8 3.3e-05 24.3 0.0 5.3 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 EWC46336.1 - 8.6e-15 54.0 3.8 0.00065 19.9 0.1 4.9 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 EWC46336.1 - 1.7e-13 50.9 6.0 4.3e-05 23.9 0.3 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 EWC46336.1 - 4.1e-10 39.8 0.4 0.0032 17.8 0.0 4.3 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EWC46336.1 - 5.7e-10 38.5 1.6 0.0066 16.4 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EWC46336.1 - 2.8e-09 37.0 5.3 0.00068 19.7 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EWC46336.1 - 9.1e-09 35.5 8.5 2.5e-05 24.5 0.2 4.3 2 1 2 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC46336.1 - 5.7e-07 29.7 5.5 3.8e-05 23.8 0.3 2.8 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EWC46336.1 - 1.7e-06 27.5 0.5 0.048 12.9 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EWC46336.1 - 6.4e-06 26.5 1.8 2.5 8.9 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 EWC46336.1 - 0.0026 17.7 0.0 4 7.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 EWC46336.1 - 0.023 15.1 3.0 11 6.4 0.1 3.5 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 EWC46336.1 - 0.033 14.1 6.8 0.079 12.9 0.3 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TOM20_plant PF06552.12 EWC46336.1 - 0.09 12.5 0.1 11 5.7 0.0 3.1 3 0 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_21 PF09976.9 EWC46336.1 - 0.22 11.2 3.1 0.47 10.1 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 EWC46336.1 - 0.26 11.4 2.9 11 6.1 0.1 3.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EWC46336.1 - 0.33 11.1 7.0 9.6 6.4 0.1 4.4 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain PDGF_N PF04692.13 EWC46337.1 - 7 7.5 8.6 2 9.2 0.4 2.5 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region NuDC PF16273.5 EWC46337.1 - 7.3 7.2 8.7 11 6.6 0.6 2.7 2 0 0 2 2 2 0 Nuclear distribution C domain Bestrophin PF01062.21 EWC46338.1 - 1.5e-19 70.6 0.0 1.7e-18 67.0 0.0 2.1 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel RP-C_C PF11800.8 EWC46338.1 - 0.069 13.2 0.3 0.71 9.9 0.0 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region Dmrt1 PF12374.8 EWC46338.1 - 2 8.9 6.2 7.8 7.0 6.2 2.0 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 GalP_UDP_transf PF01087.22 EWC46339.1 - 1.5e-69 234.2 0.0 2.6e-69 233.3 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 EWC46339.1 - 6.6e-56 188.6 0.0 1e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 EWC46339.1 - 5.1e-06 27.1 0.0 0.016 15.9 0.0 2.4 2 0 0 2 2 2 2 HIT domain DcpS_C PF11969.8 EWC46339.1 - 0.00095 19.6 0.0 0.0024 18.3 0.0 1.7 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF4931 PF16285.5 EWC46339.1 - 0.17 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4931) HLH PF00010.26 EWC46340.1 - 1.4e-13 50.6 0.7 4.5e-13 48.9 0.1 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Phage_GPO PF05929.11 EWC46340.1 - 0.0008 19.1 2.0 0.0012 18.6 2.0 1.3 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase FTA4 PF13093.6 EWC46340.1 - 0.0033 17.3 3.3 0.0049 16.8 3.3 1.2 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF4776 PF16003.5 EWC46340.1 - 0.0076 15.3 0.9 0.01 14.9 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4776) SLX9 PF15341.6 EWC46340.1 - 0.014 15.8 1.1 0.031 14.7 1.1 1.6 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 YabA PF06156.13 EWC46340.1 - 0.024 15.3 1.7 0.054 14.1 1.7 1.5 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 EWC46340.1 - 0.11 13.0 5.4 0.24 11.9 5.4 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DUF4407 PF14362.6 EWC46340.1 - 0.2 11.0 1.2 0.29 10.5 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 EWC46340.1 - 0.21 12.0 6.6 0.34 11.3 6.6 1.3 1 0 0 1 1 1 0 Fez1 Rootletin PF15035.6 EWC46340.1 - 0.26 11.3 12.8 0.52 10.3 12.8 1.5 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion FapA PF03961.13 EWC46340.1 - 0.3 9.7 0.5 0.39 9.3 0.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SEO_N PF14576.6 EWC46340.1 - 0.34 10.0 1.5 0.52 9.4 1.5 1.2 1 0 0 1 1 1 0 Sieve element occlusion N-terminus DLP_helical PF18709.1 EWC46340.1 - 0.43 9.7 2.0 0.75 8.9 2.0 1.3 1 0 0 1 1 1 0 Dynamin-like helical domain HALZ PF02183.18 EWC46340.1 - 0.74 10.1 3.6 3.1 8.1 3.6 2.1 1 1 0 1 1 1 0 Homeobox associated leucine zipper CBP4 PF07960.11 EWC46340.1 - 1.2 9.0 5.2 2.1 8.2 5.2 1.4 1 0 0 1 1 1 0 CBP4 APG6_N PF17675.1 EWC46340.1 - 1.3 9.6 6.4 2.2 8.8 6.4 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Cnn_1N PF07989.11 EWC46340.1 - 4.4 7.5 8.4 0.38 10.9 3.6 1.7 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 His_Phos_2 PF00328.22 EWC46342.1 - 1.5e-05 24.5 0.2 0.00021 20.8 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) HWE_HK PF07536.14 EWC46343.1 - 0.026 15.2 0.0 0.041 14.6 0.0 1.2 1 0 0 1 1 1 0 HWE histidine kinase NDUFB10 PF10249.9 EWC46343.1 - 0.055 14.0 0.0 0.059 13.9 0.0 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 Beta_elim_lyase PF01212.21 EWC46344.1 - 2e-68 230.8 0.0 2.4e-68 230.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EWC46344.1 - 0.00018 20.8 0.0 0.00029 20.1 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EWC46344.1 - 0.02 13.4 0.0 0.033 12.7 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF1456 PF07308.13 EWC46344.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) Ofd1_CTDD PF10637.9 EWC46345.1 - 2.7e-69 233.4 0.4 6.9e-65 218.9 1.3 2.7 2 1 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EWC46345.1 - 1.4e-25 89.8 0.0 2.8e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EWC46345.1 - 6.3e-15 55.9 0.0 1.2e-14 54.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DPPIV_N PF00930.21 EWC46347.1 - 2.1e-110 368.9 0.4 3e-110 368.3 0.4 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EWC46347.1 - 5.5e-40 137.1 0.6 9e-40 136.4 0.6 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EWC46347.1 - 0.00085 19.0 0.5 0.0052 16.4 0.2 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EWC46347.1 - 0.0031 18.1 0.0 0.0078 16.8 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family PD40 PF07676.12 EWC46347.1 - 0.017 15.1 1.2 0.36 10.8 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Esterase PF00756.20 EWC46347.1 - 0.02 14.5 0.3 0.069 12.8 0.3 1.9 1 1 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.13 EWC46347.1 - 0.081 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold BRO1 PF03097.18 EWC46348.1 - 7.9e-09 34.8 0.7 1.1e-08 34.3 0.2 1.4 2 0 0 2 2 2 1 BRO1-like domain DUF5355 PF17306.2 EWC46348.1 - 0.057 12.5 0.0 2.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5355) PAD PF03068.15 EWC46348.1 - 0.06 12.3 0.0 0.096 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) DD_K PF12121.8 EWC46348.1 - 3.6 7.8 6.2 20 5.4 0.1 2.7 2 0 0 2 2 2 0 Dermaseptin SNO PF01174.19 EWC46349.1 - 3.4e-53 180.3 0.0 5.9e-43 146.9 0.0 2.0 1 1 1 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EWC46349.1 - 1.8e-10 40.7 0.0 6.9e-09 35.6 0.0 2.1 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 EWC46349.1 - 0.0013 18.6 0.0 0.0019 18.0 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EWC46349.1 - 0.0014 18.5 0.0 0.057 13.2 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_S51 PF03575.17 EWC46349.1 - 0.0051 16.5 0.0 0.0084 15.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S51 Trypan_PARP PF05887.11 EWC46350.1 - 0.004 17.1 32.4 0.004 17.1 32.4 6.5 2 1 4 6 6 6 1 Procyclic acidic repetitive protein (PARP) RINGv PF12906.7 EWC46351.1 - 2.1e-16 59.7 12.2 3.5e-16 59.0 12.2 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EWC46351.1 - 0.0033 17.7 11.1 0.0055 17.0 11.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EWC46351.1 - 0.27 11.3 4.9 0.53 10.4 4.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Cwf_Cwc_15 PF04889.12 EWC46351.1 - 0.78 9.4 14.9 1.5 8.5 14.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Zf_RING PF16744.5 EWC46351.1 - 2.2 8.5 6.0 4 7.6 6.0 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger FANCL_C PF11793.8 EWC46351.1 - 2.2 8.5 7.0 4.5 7.5 7.0 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Baculo_IE-1 PF05290.11 EWC46351.1 - 2.8 7.9 5.8 5.6 6.9 5.8 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Nup_retrotrp_bd PF10599.9 EWC46351.1 - 3.8 8.3 13.0 9.2 7.0 0.6 3.8 3 0 0 3 3 3 0 Retro-transposon transporting motif TFIIA PF03153.13 EWC46351.1 - 6.4 6.7 27.3 0.039 14.0 16.0 2.6 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 EWC46351.1 - 9.8 5.4 14.1 18 4.5 14.1 1.4 1 0 0 1 1 1 0 BUD22 SUIM_assoc PF16619.5 EWC46353.1 - 0.41 10.7 5.8 2 8.5 5.8 2.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SGL PF08450.12 EWC46354.1 - 7.2e-27 94.5 0.0 2.3e-25 89.6 0.0 2.1 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EWC46354.1 - 0.007 16.5 0.1 0.025 14.8 0.0 2.0 1 1 1 2 2 2 1 Arylesterase NHL PF01436.21 EWC46354.1 - 0.033 14.2 0.0 23 5.3 0.0 3.2 3 0 0 3 3 3 0 NHL repeat Str_synth PF03088.16 EWC46354.1 - 0.18 12.0 0.0 0.79 9.9 0.0 2.0 2 0 0 2 2 2 0 Strictosidine synthase DUF4221 PF13970.6 EWC46354.1 - 0.2 11.1 0.0 0.41 10.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4221) p450 PF00067.22 EWC46355.1 - 8.1e-48 163.3 0.0 1.2e-47 162.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 An_peroxidase PF03098.15 EWC46356.1 - 7.2e-116 387.8 0.0 8.2e-116 387.7 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase AMP-binding PF00501.28 EWC46357.1 - 1.5e-136 455.4 0.0 5.4e-68 229.5 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EWC46357.1 - 5.1e-74 249.6 0.0 2.8e-33 115.3 0.0 4.6 3 2 0 3 3 3 3 Condensation domain PP-binding PF00550.25 EWC46357.1 - 2.2e-20 72.8 0.0 2.7e-11 43.7 0.0 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EWC46357.1 - 0.0001 23.2 0.0 0.13 13.3 0.0 2.9 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 EWC46359.1 - 1.8e-68 231.1 0.0 2.3e-68 230.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EWC46359.1 - 4.9e-12 46.0 0.3 1.5e-11 44.4 0.2 1.9 2 0 0 2 2 2 1 Phosphopantetheine attachment site Condensation PF00668.20 EWC46359.1 - 0.027 13.1 0.0 0.057 12.1 0.0 1.5 2 0 0 2 2 2 0 Condensation domain DIOX_N PF14226.6 EWC46360.1 - 3e-25 89.3 0.0 5.3e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EWC46360.1 - 2.3e-10 40.9 0.0 4.6e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TBCA PF02970.16 EWC46360.1 - 0.16 12.3 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor A GMC_oxred_N PF00732.19 EWC46362.1 - 4.7e-57 193.6 0.0 7.7e-57 192.9 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EWC46362.1 - 4.3e-26 92.2 0.0 4.3e-26 92.2 0.0 1.7 2 0 0 2 2 2 1 GMC oxidoreductase CBM_1 PF00734.18 EWC46362.1 - 5.7e-13 48.6 10.1 1.3e-12 47.4 10.1 1.7 1 0 0 1 1 1 1 Fungal cellulose binding domain DAO PF01266.24 EWC46362.1 - 0.00048 19.8 0.4 0.0051 16.4 0.3 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EWC46362.1 - 0.0027 17.9 0.8 0.013 15.7 0.1 2.6 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Mucin PF01456.17 EWC46362.1 - 0.0054 16.7 41.5 0.0054 16.7 41.5 2.1 2 0 0 2 2 2 1 Mucin-like glycoprotein TrkA_N PF02254.18 EWC46362.1 - 0.073 13.3 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Thi4 PF01946.17 EWC46362.1 - 0.56 9.4 1.5 0.77 9.0 0.0 1.8 2 0 0 2 2 2 0 Thi4 family Otopetrin PF03189.13 EWC46363.1 - 0.018 13.9 0.2 0.02 13.8 0.2 1.1 1 0 0 1 1 1 0 Otopetrin DUF348 PF03990.14 EWC46363.1 - 0.14 12.0 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain Abhydrolase_3 PF07859.13 EWC46364.1 - 2.1e-38 132.3 0.0 3e-38 131.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EWC46364.1 - 1e-08 34.5 0.3 2.2e-08 33.4 0.3 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 EWC46364.1 - 0.0054 16.6 0.0 0.019 14.8 0.0 1.9 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EWC46364.1 - 0.049 13.1 0.0 1.8 8.0 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF2974 PF11187.8 EWC46364.1 - 0.22 11.0 0.0 0.38 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) CFEM PF05730.11 EWC46365.1 - 1.8e-12 47.2 12.2 3e-12 46.4 12.2 1.3 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.20 EWC46365.1 - 0.0064 16.7 2.5 0.014 15.7 2.5 1.5 1 0 0 1 1 1 1 Gamma-thionin family DUF3583 PF12126.8 EWC46365.1 - 2 7.8 4.4 2.9 7.3 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) PSII PF00421.19 EWC46367.1 - 0.28 9.8 0.7 9.9 4.7 0.0 2.1 2 0 0 2 2 2 0 Photosystem II protein Atthog PF18800.1 EWC46367.1 - 2.1 8.3 8.7 0.19 11.6 2.4 2.1 2 0 0 2 2 2 0 Attenuator of Hedgehog Glyco_hydro_45 PF02015.16 EWC46368.1 - 4.8e-67 225.9 14.1 9.8e-67 224.9 14.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 CBM_1 PF00734.18 EWC46368.1 - 4.1e-14 52.2 10.6 4.1e-14 52.2 10.6 3.0 2 0 0 2 2 2 1 Fungal cellulose binding domain Mucin PF01456.17 EWC46368.1 - 0.00014 21.9 45.4 0.00035 20.6 45.4 1.7 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF908 PF06012.12 EWC46368.1 - 0.27 10.6 5.8 0.36 10.2 5.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Ctf8 PF09696.10 EWC46369.1 - 0.081 13.3 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Ctf8 Pyrid_oxidase_2 PF13883.6 EWC46370.1 - 2.7e-44 151.1 0.0 3.2e-44 150.9 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase SesA PF17107.5 EWC46372.1 - 0.0004 20.5 0.0 0.0015 18.7 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases SH3_2 PF07653.17 EWC46372.1 - 0.015 15.0 0.1 0.036 13.7 0.1 1.7 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 EWC46372.1 - 0.036 13.7 0.5 0.087 12.4 0.5 1.7 1 0 0 1 1 1 0 SH3 domain SH3_9 PF14604.6 EWC46372.1 - 0.073 12.9 0.2 0.16 11.9 0.2 1.6 1 0 0 1 1 1 0 Variant SH3 domain HisKA PF00512.25 EWC46372.1 - 0.097 12.7 0.1 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain UvrD-helicase PF00580.21 EWC46373.1 - 4.5e-14 52.7 0.0 4.6e-11 42.8 0.0 2.3 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EWC46373.1 - 1.8e-11 44.2 0.0 0.0017 18.2 0.0 4.1 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase UvrD_C PF13361.6 EWC46373.1 - 7.8e-11 41.9 0.0 1.5e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EWC46373.1 - 1.7e-10 41.4 0.0 3.1e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EWC46373.1 - 1.9e-09 37.2 1.3 4.7e-09 35.9 0.1 2.3 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EWC46373.1 - 0.0014 18.3 0.0 1 9.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 EWC46373.1 - 0.017 14.5 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein FAS_N PF17828.1 EWC46373.1 - 0.17 11.9 0.0 30 4.6 0.0 2.5 2 0 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta Tyrosinase PF00264.20 EWC46374.1 - 3.8e-42 145.1 2.1 3.8e-42 145.1 2.1 2.1 3 0 0 3 3 3 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EWC46374.1 - 6.7e-21 75.2 0.0 1.7e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 Tyosinase C-terminal domain Abhydrolase_3 PF07859.13 EWC46376.1 - 1.4e-11 44.7 0.1 5.4e-08 32.9 0.0 3.2 2 1 0 3 3 3 2 alpha/beta hydrolase fold MFS_1 PF07690.16 EWC46378.1 - 1.4e-39 136.1 30.9 1.6e-39 135.9 27.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC46378.1 - 1.4e-12 47.3 7.1 1.4e-12 47.3 7.1 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EWC46378.1 - 4e-11 42.1 1.9 7.8e-11 41.1 1.9 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Flavokinase PF01687.17 EWC46379.1 - 6.2e-36 123.1 0.0 7.7e-36 122.8 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase DUF1365 PF07103.11 EWC46380.1 - 8.7e-44 150.0 0.2 1.4e-43 149.3 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) Dus PF01207.17 EWC46380.1 - 0.054 12.6 0.0 2.7 7.0 0.0 2.1 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) p450 PF00067.22 EWC46381.1 - 1.1e-26 93.6 0.0 2.5e-25 89.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 CorA PF01544.18 EWC46382.1 - 1.8e-15 57.0 0.7 3e-13 49.8 0.1 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein HECT PF00632.25 EWC46383.1 - 4.3e-72 243.2 0.0 1.1e-55 189.3 0.0 2.4 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EWC46383.1 - 9e-22 77.1 2.7 2.6e-21 75.6 2.7 1.9 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Pkinase PF00069.25 EWC46384.1 - 5.9e-69 232.4 0.0 8e-69 231.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46384.1 - 4.8e-30 104.7 0.0 7.7e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EWC46384.1 - 0.0014 17.7 0.0 0.0077 15.2 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EWC46384.1 - 0.019 14.9 0.1 0.051 13.5 0.1 1.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EWC46384.1 - 0.14 11.4 0.1 0.56 9.5 0.1 1.8 1 1 0 1 1 1 0 Kinase-like 2OG-FeII_Oxy_2 PF13532.6 EWC46385.1 - 1.4e-25 90.6 0.0 2.3e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily His_Phos_1 PF00300.22 EWC46386.1 - 8.8e-16 58.2 0.0 3.3e-08 33.5 0.0 2.4 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF515 PF04415.12 EWC46387.1 - 8.1 4.7 6.3 16 3.8 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) KCH PF16944.5 EWC46388.1 - 1.2e-87 293.9 8.7 1.4e-87 293.6 8.7 1.1 1 0 0 1 1 1 1 Fungal potassium channel Transket_pyr PF02779.24 EWC46389.1 - 1.5e-40 138.7 0.0 3.5e-40 137.6 0.0 1.6 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EWC46389.1 - 6.4e-33 113.3 0.1 1.2e-32 112.4 0.1 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EWC46389.1 - 0.0086 16.4 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Dak2 PF02734.17 EWC46390.1 - 0.017 15.0 3.4 0.017 15.0 3.4 1.9 2 0 0 2 2 2 0 DAK2 domain TraQ PF09679.10 EWC46390.1 - 0.25 11.3 0.0 0.25 11.3 0.0 2.6 2 1 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) Big_5 PF13205.6 EWC46392.1 - 0.021 15.5 0.9 0.04 14.6 0.1 1.8 2 1 0 2 2 2 0 Bacterial Ig-like domain Corona_NS4 PF03905.13 EWC46393.1 - 0.0093 16.0 0.0 0.0093 16.0 0.0 3.4 2 1 1 3 3 3 1 Coronavirus non-structural protein NS4 SKG6 PF08693.10 EWC46393.1 - 0.024 14.0 0.1 0.024 14.0 0.1 2.4 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF295 PF03478.18 EWC46393.1 - 0.042 13.4 0.1 0.077 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF295) DUF5379 PF17350.2 EWC46393.1 - 0.34 11.2 3.0 0.55 10.5 0.5 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5379) Perilipin PF03036.16 EWC46393.1 - 3 6.8 7.2 4 6.4 7.2 1.1 1 0 0 1 1 1 0 Perilipin family SprA-related PF12118.8 EWC46394.1 - 0.0069 15.6 2.4 0.011 15.0 2.4 1.2 1 0 0 1 1 1 1 SprA-related family AP1AR PF15745.5 EWC46394.1 - 0.71 9.5 9.3 1.1 8.8 9.3 1.2 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein HemX PF04375.14 EWC46394.1 - 2.2 7.5 10.4 3.2 7.0 10.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase LUC7 PF03194.15 EWC46395.1 - 6.1e-72 242.3 0.2 7.5e-72 242.0 0.2 1.0 1 0 0 1 1 1 1 LUC7 N_terminus gpW PF02831.15 EWC46395.1 - 0.0049 16.7 0.9 0.54 10.2 0.1 3.1 3 0 0 3 3 3 1 gpW DUF2225 PF09986.9 EWC46395.1 - 0.14 11.8 0.3 1.2 8.9 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Dynamin_M PF01031.20 EWC46396.1 - 3.2e-29 102.1 0.4 1.4e-18 67.1 0.1 2.2 2 0 0 2 2 2 2 Dynamin central region Dynamin_N PF00350.23 EWC46396.1 - 3.6e-25 89.0 0.0 1.1e-24 87.3 0.0 1.9 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EWC46396.1 - 7.1e-07 29.3 0.0 3.6e-06 27.0 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 EWC46396.1 - 0.0013 18.8 3.1 0.0041 17.3 0.1 3.3 3 0 0 3 3 3 1 Dynamin GTPase effector domain FeoB_N PF02421.18 EWC46396.1 - 0.0071 15.9 0.0 0.39 10.2 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_29 PF13555.6 EWC46396.1 - 0.063 13.0 0.0 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EWC46396.1 - 0.07 13.6 0.0 0.27 11.8 0.0 2.0 2 0 0 2 2 2 0 ABC transporter DUF726 PF05277.12 EWC46396.1 - 0.11 11.4 1.4 0.18 10.7 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) AAA_21 PF13304.6 EWC46396.1 - 0.12 12.2 0.0 0.34 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EWC46396.1 - 0.13 12.7 0.4 6.7 7.1 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain Fe-ADH PF00465.19 EWC46397.1 - 5.5e-101 338.0 0.0 6.8e-101 337.7 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EWC46397.1 - 3.7e-14 53.0 0.0 2e-09 37.6 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase RNA_pol_L_2 PF13656.6 EWC46397.1 - 0.11 12.3 0.2 0.4 10.5 0.2 2.0 1 1 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain VHS PF00790.19 EWC46398.1 - 6.5e-22 77.9 0.0 1.7e-21 76.6 0.0 1.6 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EWC46398.1 - 0.00096 19.4 0.2 0.0019 18.4 0.2 1.5 1 0 0 1 1 1 1 GAT domain HSP70 PF00012.20 EWC46399.1 - 1.7e-258 858.8 13.2 1.9e-258 858.6 13.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EWC46399.1 - 3.5e-18 65.5 1.5 8.9e-17 60.9 0.4 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EWC46399.1 - 0.00071 20.0 3.3 0.38 11.2 0.0 3.6 3 1 0 3 3 3 2 Cell division protein FtsA FIVAR PF07554.13 EWC46399.1 - 0.011 16.5 3.1 0.25 12.1 0.3 3.6 3 1 0 3 3 3 0 FIVAR domain HEPPP_synt_1 PF07307.11 EWC46399.1 - 0.015 14.9 1.0 0.015 14.9 1.0 1.7 2 0 0 2 2 2 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Hydantoinase_A PF01968.18 EWC46399.1 - 0.2 10.9 7.4 0.15 11.3 0.1 3.3 4 0 0 4 4 4 0 Hydantoinase/oxoprolinase Pantoate_ligase PF02569.15 EWC46400.1 - 6e-92 307.6 0.0 6.8e-92 307.4 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Rtf2 PF04641.12 EWC46401.1 - 7.5e-59 199.2 1.4 9.8e-59 198.8 1.4 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 EWC46401.1 - 2.8e-05 23.8 0.0 0.016 15.0 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EWC46401.1 - 0.0044 17.0 0.1 0.082 12.9 0.0 2.7 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EWC46401.1 - 0.0091 15.8 0.5 0.045 13.6 0.2 2.2 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EWC46401.1 - 0.01 16.1 0.0 0.12 12.7 0.1 2.3 1 1 1 2 2 2 0 Ring finger domain zf-RING_11 PF17123.5 EWC46401.1 - 0.017 14.9 0.6 0.86 9.4 0.1 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.6 EWC46401.1 - 0.043 13.8 0.0 0.083 12.9 0.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain PRTP PF01366.18 EWC46401.1 - 0.22 9.6 4.6 0.28 9.2 4.6 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein Tim17 PF02466.19 EWC46402.1 - 9.7e-31 106.4 8.6 1.2e-30 106.1 8.6 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family tRNA-synt_2 PF00152.20 EWC46403.1 - 3.4e-77 259.6 1.9 4.5e-77 259.2 1.9 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EWC46403.1 - 4.5e-09 36.2 0.0 9.9e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EWC46403.1 - 4.6e-06 26.3 0.1 0.0063 16.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DHHW PF14286.6 EWC46403.1 - 0.17 11.2 0.0 0.34 10.2 0.0 1.4 1 0 0 1 1 1 0 DHHW protein UCH PF00443.29 EWC46404.1 - 3e-60 203.9 0.0 5.5e-60 203.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EWC46404.1 - 2.3e-20 73.4 0.0 4e-19 69.4 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EWC46404.1 - 0.00021 21.8 0.0 0.00065 20.2 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain zf-MIZ PF02891.20 EWC46404.1 - 0.02 14.6 0.2 0.041 13.6 0.2 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger VHS PF00790.19 EWC46405.1 - 7.6e-41 139.3 0.1 7.6e-41 139.3 0.1 2.0 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 EWC46405.1 - 1.6e-17 63.4 6.1 3.5e-17 62.3 6.1 1.6 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 EWC46405.1 - 0.019 15.2 5.0 0.042 14.1 5.0 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger UIM PF02809.20 EWC46405.1 - 0.021 14.7 14.3 0.15 12.0 3.7 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif RAP80_UIM PF18282.1 EWC46405.1 - 0.036 13.9 1.8 4.2 7.2 0.0 2.5 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif GAT PF03127.14 EWC46405.1 - 0.039 14.3 0.0 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 GAT domain KNTase_C PF07827.11 EWC46405.1 - 0.16 11.8 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 KNTase C-terminal domain APG12 PF04110.13 EWC46406.1 - 4e-25 88.0 0.3 1.4e-15 57.4 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-like autophagy protein Apg12 Asparaginase_2 PF01112.18 EWC46407.1 - 2.1e-72 243.8 0.0 5.3e-59 199.7 0.0 2.1 2 0 0 2 2 2 2 Asparaginase TPT PF03151.16 EWC46408.1 - 0.024 14.0 9.0 0.68 9.2 9.0 2.8 1 1 0 1 1 1 0 Triose-phosphate Transporter family AAA_lid_5 PF17865.1 EWC46408.1 - 0.75 9.9 2.6 1.5 8.9 0.3 2.4 3 0 0 3 3 3 0 Midasin AAA lid domain DUF1440 PF07274.12 EWC46408.1 - 6.3 7.2 8.7 1.2 9.4 0.5 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF1440) CYTH PF01928.21 EWC46409.1 - 9.7e-15 54.9 0.0 1.5e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 CYTH domain Radical_SAM PF04055.21 EWC46410.1 - 2.6e-14 53.9 0.1 5.5e-14 52.9 0.1 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EWC46410.1 - 2.6e-07 31.0 0.1 5.6e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EWC46410.1 - 6.9e-07 29.4 0.4 2.1e-06 27.9 0.1 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain zf-C2H2_7 PF15269.6 EWC46410.1 - 0.12 12.5 3.1 0.61 10.2 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger COX15-CtaA PF02628.15 EWC46412.1 - 1.3e-102 343.2 0.5 1.7e-102 342.8 0.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein p450 PF00067.22 EWC46413.1 - 1.6e-77 261.2 0.0 2e-77 260.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HypD PF01924.16 EWC46413.1 - 0.016 14.3 0.0 0.025 13.7 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase formation hypA family DUF1196 PF06709.11 EWC46413.1 - 0.12 12.5 0.2 0.32 11.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1196) DUF2828 PF11443.8 EWC46414.1 - 5.7e-204 678.8 0.0 2.8e-160 534.5 0.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF2828) Asp PF00026.23 EWC46415.1 - 6.4e-19 68.5 0.0 9.1e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease CD99L2 PF12301.8 EWC46415.1 - 0.029 14.7 0.0 0.051 13.9 0.0 1.3 1 0 0 1 1 1 0 CD99 antigen like protein 2 SKG6 PF08693.10 EWC46415.1 - 0.27 10.7 3.4 0.11 12.0 0.3 1.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain MARVEL PF01284.23 EWC46416.1 - 0.0039 17.2 17.1 0.0064 16.5 17.1 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF2569 PF10754.9 EWC46416.1 - 0.64 10.4 9.3 0.85 10.1 6.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) DUF4234 PF14018.6 EWC46416.1 - 0.72 10.0 7.7 2.6 8.2 0.3 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) DUF2304 PF10066.9 EWC46416.1 - 1.1 9.6 8.9 2.1 8.6 8.9 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) zf-C2H2_2 PF12756.7 EWC46417.1 - 1.5e-33 115.1 16.3 9.1e-31 106.2 0.1 3.6 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EWC46417.1 - 3.9e-06 27.0 16.4 7.8e-05 22.8 0.5 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EWC46417.1 - 0.00034 21.2 10.7 2.4 9.2 0.4 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.7 EWC46417.1 - 0.001 19.4 0.8 0.001 19.4 0.8 3.4 4 0 0 4 4 4 2 Zinc-finger of C2H2 type Actin_micro PF17003.5 EWC46417.1 - 0.43 9.7 1.8 8.6 5.4 0.1 2.2 2 0 0 2 2 2 0 Putative actin-like family zf-C2H2 PF00096.26 EWC46417.1 - 3 8.5 20.9 0.14 12.6 1.3 4.3 4 1 0 4 4 4 0 Zinc finger, C2H2 type DASH_Hsk3 PF08227.11 EWC46417.1 - 5.3 7.5 6.2 9.7 6.6 1.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Peptidase_M20 PF01546.28 EWC46418.1 - 4e-23 82.2 0.0 6.5e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EWC46418.1 - 1.1e-07 31.8 0.0 2.9e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.32 EWC46418.1 - 5.6e-07 30.2 14.5 0.3 12.0 0.4 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC46418.1 - 0.00053 20.2 0.0 5.6 7.3 0.0 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M28 PF04389.17 EWC46418.1 - 0.029 14.0 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Na_Ca_ex PF01699.24 EWC46419.1 - 6.2e-41 139.9 41.3 1.3e-22 80.4 19.8 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SR-25 PF10500.9 EWC46419.1 - 0.29 10.7 12.5 0.6 9.7 12.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein F-box-like PF12937.7 EWC46421.1 - 0.13 12.2 0.0 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 F-box-like Cu_bind_like PF02298.17 EWC46422.1 - 0.00057 19.8 0.2 0.0014 18.6 0.2 1.7 1 1 0 1 1 1 1 Plastocyanin-like domain VP4_2 PF08935.10 EWC46422.1 - 0.11 13.0 0.3 0.84 10.3 0.1 2.1 2 0 0 2 2 2 0 Viral protein VP4 subunit MENTAL PF10457.9 EWC46423.1 - 0.11 12.4 0.8 0.15 11.9 0.8 1.2 1 0 0 1 1 1 0 Cholesterol-capturing domain DUF2070 PF09843.9 EWC46423.1 - 0.41 8.9 4.3 0.52 8.5 4.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Atx10homo_assoc PF09759.9 EWC46424.1 - 8.3e-33 112.4 0.3 2e-32 111.2 0.3 1.7 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain DUF4290 PF14123.6 EWC46424.1 - 0.055 13.0 0.0 5.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4290) DUF21 PF01595.20 EWC46425.1 - 6.5e-36 123.7 0.0 9.8e-36 123.1 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EWC46425.1 - 9e-06 26.0 0.2 0.062 13.7 0.0 3.0 3 0 0 3 3 3 2 CBS domain Transp_cyt_pur PF02133.15 EWC46426.1 - 1.1e-83 281.4 28.9 1.4e-83 281.1 28.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin CVNH PF08881.10 EWC46428.1 - 2.7e-12 47.2 0.0 9.2e-09 35.9 0.0 2.4 1 1 1 2 2 2 2 CVNH domain DUF4630 PF15443.6 EWC46428.1 - 1.8 8.8 4.9 0.47 10.6 1.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4630) DUF4841 PF16129.5 EWC46429.1 - 0.02 15.1 0.1 0.05 13.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4841) F-box PF00646.33 EWC46430.1 - 0.19 11.7 0.0 0.19 11.7 0.0 2.6 3 0 0 3 3 3 0 F-box domain zf-RING_2 PF13639.6 EWC46431.1 - 5.2e-08 33.1 3.4 7.9e-08 32.5 3.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EWC46431.1 - 1e-05 25.7 6.2 0.00014 22.0 6.3 2.2 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EWC46431.1 - 0.0007 19.6 6.7 0.0013 18.7 6.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EWC46431.1 - 0.0011 19.0 0.7 0.0017 18.4 0.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EWC46431.1 - 0.022 14.6 6.1 0.26 11.2 6.8 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EWC46431.1 - 0.04 13.7 1.8 0.078 12.7 1.8 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EWC46431.1 - 0.16 11.9 1.6 1 9.2 1.7 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC46431.1 - 0.17 11.8 1.1 0.4 10.6 1.1 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF747 PF05346.11 EWC46432.1 - 1.3e-116 389.5 0.4 2.1e-116 388.9 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family Putative_PNPOx PF01243.20 EWC46433.1 - 5.1e-10 39.4 0.0 7.6e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EWC46433.1 - 6.1e-05 23.3 0.0 0.0022 18.3 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EWC46433.1 - 0.0061 17.2 0.0 0.012 16.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EWC46433.1 - 0.093 12.9 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain BRCT_2 PF16589.5 EWC46434.1 - 2.3e-12 47.2 0.0 5.9e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Rap1_C PF11626.8 EWC46434.1 - 6.7e-10 38.9 0.1 1.6e-09 37.7 0.1 1.7 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 EWC46434.1 - 8.2e-09 35.5 2.4 8.2e-09 35.5 2.4 2.1 2 0 0 2 2 2 1 Rap1 Myb domain MutL PF13941.6 EWC46434.1 - 0.2 10.2 0.0 0.34 9.5 0.0 1.3 1 0 0 1 1 1 0 MutL protein DHHC PF01529.20 EWC46435.1 - 3.6e-32 111.3 15.5 3.6e-32 111.3 15.5 1.9 3 0 0 3 3 3 1 DHHC palmitoyltransferase 2C_adapt PF08793.10 EWC46435.1 - 0.032 14.4 0.0 0.071 13.3 0.0 1.5 1 0 0 1 1 1 0 2-cysteine adaptor domain F-box-like PF12937.7 EWC46436.1 - 0.002 18.0 0.2 0.0045 16.8 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC46436.1 - 0.046 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 F-box domain VHL_C PF17211.3 EWC46436.1 - 0.13 12.3 0.0 0.39 10.8 0.0 1.8 1 0 0 1 1 1 0 VHL box domain SelR PF01641.18 EWC46437.1 - 1.5e-50 170.4 0.1 1.7e-50 170.1 0.1 1.0 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 EWC46437.1 - 0.024 14.4 0.2 2.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Tnp_zf-ribbon_2 PF13842.6 EWC46437.1 - 0.059 14.2 0.4 17 6.3 0.0 2.4 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon GFA PF04828.14 EWC46437.1 - 0.077 13.3 0.9 1.1 9.6 0.1 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme TF_Zn_Ribbon PF08271.12 EWC46437.1 - 0.2 11.2 0.2 0.2 11.2 0.2 2.5 3 0 0 3 3 3 0 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EWC46437.1 - 0.39 10.2 7.9 1.6 8.2 0.1 3.0 4 0 0 4 4 4 0 zinc-ribbon domain DZR PF12773.7 EWC46437.1 - 0.52 10.4 3.2 10 6.2 3.2 2.2 1 1 1 2 2 2 0 Double zinc ribbon Carb_anhydrase PF00194.21 EWC46438.1 - 2.3e-18 66.7 0.0 5.6e-18 65.4 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase MFS_1 PF07690.16 EWC46439.1 - 9.7e-41 139.9 48.8 9.7e-41 139.9 48.8 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC46439.1 - 7e-12 44.9 12.4 7e-12 44.9 12.4 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter Phage_holin_2_2 PF10746.9 EWC46439.1 - 0.057 13.1 0.5 0.23 11.1 0.1 2.3 2 0 0 2 2 2 0 Phage holin T7 family, holin superfamily II NTP_transferase PF00483.23 EWC46440.1 - 7.5e-32 110.9 0.0 1.2e-31 110.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EWC46440.1 - 6.8e-08 31.9 3.0 3.5e-05 23.4 0.0 3.4 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EWC46440.1 - 8.3e-07 29.5 0.0 1.6e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 EWC46440.1 - 0.0019 17.2 0.1 1.3 7.9 0.0 2.1 2 0 0 2 2 2 2 L-fucokinase Peptidase_S28 PF05577.12 EWC46442.1 - 5e-50 170.6 0.4 9.4e-50 169.7 0.4 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase S28 APH PF01636.23 EWC46443.1 - 1.1e-07 32.0 0.0 2.6e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Ran-binding PF05508.11 EWC46444.1 - 5.2e-108 360.7 0.0 8.5e-108 360.0 0.0 1.3 1 0 0 1 1 1 1 RanGTP-binding protein Rx_N PF18052.1 EWC46444.1 - 0.021 15.1 0.0 0.07 13.4 0.0 1.8 1 0 0 1 1 1 0 Rx N-terminal domain SDA1 PF05285.12 EWC46444.1 - 8.7 5.7 10.5 0.66 9.3 4.7 2.0 2 0 0 2 2 2 0 SDA1 Copper-fist PF00649.18 EWC46445.1 - 1.3e-20 72.6 1.5 1.3e-20 72.6 1.5 2.4 2 1 1 3 3 3 1 Copper fist DNA binding domain Metallothio_Pro PF02069.16 EWC46445.1 - 2.5 8.4 12.5 0.14 12.4 1.6 3.1 3 0 0 3 3 3 0 Prokaryotic metallothionein Fungal_trans PF04082.18 EWC46446.1 - 2e-05 23.8 0.0 3.9e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zds_C PF08632.10 EWC46447.1 - 1e-30 105.2 2.6 1.9e-30 104.3 2.6 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term CBP_BcsG PF11658.8 EWC46447.1 - 1.2 7.4 7.0 1.8 6.8 7.0 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG KH_1 PF00013.29 EWC46448.1 - 2.3e-114 373.3 43.2 7.4e-15 54.5 0.2 14.5 14 1 0 14 14 14 13 KH domain KH_2 PF07650.17 EWC46448.1 - 1.2e-08 34.7 32.2 0.0075 16.1 1.3 9.3 8 1 1 9 9 9 4 KH domain SLS PF14611.6 EWC46448.1 - 2.4e-08 34.1 12.0 0.0013 18.6 0.2 6.8 6 1 1 8 8 8 2 Mitochondrial inner-membrane-bound regulator ACT PF01842.25 EWC46448.1 - 1.3 8.9 4.6 9.6 6.1 0.0 4.2 5 0 0 5 5 5 0 ACT domain KH_4 PF13083.6 EWC46448.1 - 3 7.8 24.1 0.38 10.7 0.6 7.5 8 0 0 8 8 8 0 KH domain GTP_EFTU PF00009.27 EWC46449.1 - 1.5e-42 145.4 0.0 2.4e-42 144.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EWC46449.1 - 1.4e-28 99.5 0.0 3.2e-28 98.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EWC46449.1 - 2.9e-07 30.8 0.1 7.9e-07 29.4 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EWC46449.1 - 0.0032 17.6 0.1 0.019 15.1 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase IFT81_CH PF18383.1 EWC46449.1 - 0.2 11.9 0.0 0.42 10.9 0.0 1.4 1 0 0 1 1 1 0 Intraflagellar transport 81 calponin homology domain GRP PF07172.11 EWC46449.1 - 0.49 11.1 23.2 1.9 9.2 23.2 2.1 1 0 0 1 1 1 0 Glycine rich protein family TFIIA PF03153.13 EWC46449.1 - 1.3 9.0 17.7 2.2 8.2 17.7 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EF_assoc_2 PF08356.12 EWC46450.1 - 4.6e-35 119.5 0.0 1e-34 118.4 0.0 1.6 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EWC46450.1 - 1.8e-26 91.5 0.6 3.3e-26 90.7 0.6 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EWC46450.1 - 2.5e-16 59.7 0.0 8.3e-09 35.2 0.0 2.2 2 0 0 2 2 2 2 Ras family EF-hand_1 PF00036.32 EWC46450.1 - 6.3e-08 31.6 1.4 0.004 16.6 0.0 2.7 2 0 0 2 2 2 2 EF hand Roc PF08477.13 EWC46450.1 - 1.8e-07 31.4 0.0 0.0055 16.9 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EWC46450.1 - 2.4e-07 30.8 0.0 0.049 13.7 0.0 3.1 3 1 0 3 3 3 2 50S ribosome-binding GTPase EF-hand_6 PF13405.6 EWC46450.1 - 3.5e-07 29.6 0.9 0.0031 17.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EWC46450.1 - 4.5e-07 30.2 0.0 0.0084 16.5 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair Dynamin_N PF00350.23 EWC46450.1 - 7.3e-07 29.4 0.0 0.0055 16.8 0.0 2.5 2 0 0 2 2 2 2 Dynamin family EF-hand_5 PF13202.6 EWC46450.1 - 0.00024 20.4 2.6 0.016 14.7 0.2 2.7 2 0 0 2 2 2 1 EF hand AAA_29 PF13555.6 EWC46450.1 - 0.00053 19.7 0.0 0.024 14.4 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EWC46450.1 - 0.0013 19.0 0.1 0.13 12.5 0.0 2.8 3 0 0 3 3 3 1 AAA domain EF-hand_8 PF13833.6 EWC46450.1 - 0.0044 16.8 0.6 1.9 8.4 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair AAA_16 PF13191.6 EWC46450.1 - 0.0049 17.3 0.0 0.68 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain EF-hand_10 PF14788.6 EWC46450.1 - 0.017 14.9 3.0 0.019 14.8 0.3 2.4 3 0 0 3 3 3 0 EF hand GTP_EFTU PF00009.27 EWC46450.1 - 0.03 13.8 0.0 12 5.4 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EWC46450.1 - 0.11 12.0 0.0 8 5.8 0.0 2.6 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_15 PF13175.6 EWC46450.1 - 0.12 12.1 0.0 9.8 5.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 EWC46450.1 - 0.14 12.7 0.0 32 5.1 0.1 3.1 2 1 0 2 2 2 0 AAA domain GST_N_2 PF13409.6 EWC46451.1 - 4.1e-22 78.3 0.0 8e-22 77.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EWC46451.1 - 1.3e-14 53.9 0.0 2.6e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EWC46451.1 - 5.8e-06 26.4 0.1 2.9e-05 24.2 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EWC46451.1 - 1.6e-05 25.1 0.1 3e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EWC46451.1 - 0.00058 20.2 0.0 0.0052 17.2 0.0 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GTP_EFTU PF00009.27 EWC46452.1 - 5.1e-48 163.2 0.0 8e-48 162.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EWC46452.1 - 1.6e-18 66.8 0.3 3.2e-18 65.8 0.3 1.4 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.23 EWC46452.1 - 9.1e-08 32.2 0.0 0.0012 18.9 0.0 2.7 1 1 1 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EWC46452.1 - 3.7e-07 30.4 1.0 1.2e-06 28.9 1.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EWC46452.1 - 1.3e-05 25.4 0.0 5.4e-05 23.5 0.0 2.2 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain Ras PF00071.22 EWC46452.1 - 0.0014 18.3 0.0 0.041 13.5 0.0 2.3 1 1 1 2 2 2 1 Ras family SRPRB PF09439.10 EWC46452.1 - 0.0087 15.5 0.0 0.98 8.8 0.0 2.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EWC46452.1 - 0.012 15.8 0.1 8.6 6.6 0.0 2.7 2 1 1 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EWC46452.1 - 0.027 14.4 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EWC46452.1 - 0.033 14.5 0.0 0.06 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EWC46452.1 - 0.044 12.9 0.0 0.097 11.8 0.0 1.6 1 0 0 1 1 1 0 G-protein alpha subunit Septin PF00735.18 EWC46452.1 - 0.087 12.1 0.0 0.37 10.0 0.0 2.0 2 1 0 2 2 2 0 Septin Peptidase_M14 PF00246.24 EWC46453.1 - 2e-74 251.0 0.0 2.4e-74 250.7 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase ANP PF00212.18 EWC46453.1 - 0.21 11.8 0.8 0.4 10.9 0.8 1.5 1 0 0 1 1 1 0 Atrial natriuretic peptide CFEM PF05730.11 EWC46454.1 - 0.011 15.7 0.8 0.011 15.7 0.8 1.7 2 0 0 2 2 2 0 CFEM domain Rax2 PF12768.7 EWC46454.1 - 0.013 15.0 0.0 0.02 14.3 0.0 1.4 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DUF347 PF03988.12 EWC46454.1 - 0.019 15.1 2.3 0.033 14.4 2.3 1.4 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) SKG6 PF08693.10 EWC46454.1 - 0.04 13.3 2.9 0.084 12.3 2.9 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Med3 PF11593.8 EWC46454.1 - 0.57 9.3 14.3 0.76 8.9 14.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Tannase PF07519.11 EWC46455.1 - 4.1e-93 312.8 0.0 5.4e-93 312.4 0.0 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 EWC46455.1 - 0.062 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC46455.1 - 0.073 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EWC46457.1 - 7.5e-11 42.1 0.0 1.2e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EWC46457.1 - 1.8e-08 35.3 2.8 2.5e-08 34.8 2.8 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF4474 PF14751.6 EWC46457.1 - 0.11 11.9 0.3 0.36 10.2 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4474) Glyco_hydro_62 PF03664.13 EWC46459.1 - 2.3e-144 479.7 14.9 2.9e-144 479.4 14.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 CBM_1 PF00734.18 EWC46459.1 - 1.9e-10 40.5 10.1 5.5e-10 39.0 10.1 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain TauD PF02668.16 EWC46460.1 - 5.4e-13 49.3 1.7 6e-11 42.6 1.7 2.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EWC46460.1 - 0.004 16.3 0.0 0.0062 15.7 0.0 1.2 1 0 0 1 1 1 1 CsiD ABC_tran PF00005.27 EWC46461.1 - 8.2e-49 165.6 0.0 4.8e-25 88.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EWC46461.1 - 3.4e-32 112.2 16.1 6.7e-32 111.2 16.1 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EWC46461.1 - 3.3e-11 43.1 0.8 0.017 14.6 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EWC46461.1 - 7.3e-11 42.4 0.7 0.025 14.4 0.0 4.2 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EWC46461.1 - 1.1e-06 29.0 0.1 0.014 15.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EWC46461.1 - 1.3e-05 24.9 0.9 0.03 14.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EWC46461.1 - 4.1e-05 23.5 1.2 0.0076 16.2 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA PF00004.29 EWC46461.1 - 7.7e-05 23.1 0.1 0.11 12.9 0.0 3.4 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC46461.1 - 0.00016 22.1 0.2 0.64 10.4 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EWC46461.1 - 0.00033 20.8 0.0 0.073 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EWC46461.1 - 0.0012 18.6 0.1 0.0033 17.2 0.1 1.7 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EWC46461.1 - 0.0014 18.4 0.2 0.32 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EWC46461.1 - 0.0025 17.9 1.3 0.75 9.9 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Rad17 PF03215.15 EWC46461.1 - 0.0035 17.3 1.2 0.21 11.5 0.1 3.2 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_25 PF13481.6 EWC46461.1 - 0.0037 16.9 0.7 0.038 13.6 0.0 2.6 3 0 0 3 3 2 1 AAA domain DUF3290 PF11694.8 EWC46461.1 - 0.0044 17.0 0.3 0.0044 17.0 0.3 2.6 3 0 0 3 3 2 1 Protein of unknown function (DUF3290) AAA_23 PF13476.6 EWC46461.1 - 0.0066 17.0 0.4 0.62 10.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EWC46461.1 - 0.01 15.8 0.6 0.86 9.6 0.1 3.4 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EWC46461.1 - 0.011 15.3 0.1 1.7 8.1 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EWC46461.1 - 0.015 14.7 0.2 2.9 7.2 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF815 PF05673.13 EWC46461.1 - 0.018 14.2 0.0 7 5.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EWC46461.1 - 0.027 14.8 2.4 2.7 8.4 0.0 3.3 3 0 0 3 3 2 0 RNA helicase Roc PF08477.13 EWC46461.1 - 0.028 14.6 0.1 1.4 9.1 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 EWC46461.1 - 0.032 13.9 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_30 PF13604.6 EWC46461.1 - 0.056 13.1 0.4 8.6 6.0 0.1 2.7 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EWC46461.1 - 0.064 13.2 2.1 0.72 9.8 0.2 2.5 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 EWC46461.1 - 0.07 13.5 0.2 7.9 6.8 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EWC46461.1 - 0.12 12.1 0.3 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain UPF0175 PF03683.13 EWC46461.1 - 0.13 12.0 0.2 22 4.8 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) AAA_14 PF13173.6 EWC46461.1 - 0.17 11.9 0.1 0.63 10.1 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EWC46461.1 - 0.19 12.3 0.8 16 6.0 0.1 2.6 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EWC46461.1 - 0.27 10.8 3.7 0.11 12.1 0.4 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 EWC46461.1 - 0.31 11.1 1.5 0.47 10.5 0.1 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain PAS_9 PF13426.7 EWC46465.1 - 2.8e-15 56.5 0.0 1.3e-12 47.8 0.0 2.8 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 EWC46465.1 - 0.0001 22.2 0.0 0.00029 20.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EWC46465.1 - 0.00031 20.9 0.0 0.24 11.6 0.0 2.7 2 0 0 2 2 2 2 PAS fold DEAD PF00270.29 EWC46466.1 - 5.4e-47 159.8 0.0 9.3e-47 159.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC46466.1 - 2.3e-30 105.2 0.0 4.6e-28 97.8 0.0 2.8 2 1 1 3 3 3 1 Helicase conserved C-terminal domain LYRIC PF15686.5 EWC46466.1 - 3.9 6.9 37.4 5.9 6.3 37.4 1.3 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Peptidase_S64 PF08192.11 EWC46466.1 - 6.3 5.1 16.1 11 4.3 16.1 1.3 1 0 0 1 1 1 0 Peptidase family S64 CSTF2_hinge PF14327.6 EWC46467.1 - 8.7e-31 106.2 3.6 8.7e-31 106.2 3.6 2.4 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 EWC46467.1 - 8.7e-21 73.5 0.0 1.3e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 EWC46467.1 - 1.3e-16 59.9 9.6 1.3e-16 59.9 9.6 2.5 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal RRM_occluded PF16842.5 EWC46467.1 - 0.034 14.0 0.0 0.62 10.0 0.0 2.5 2 1 0 2 2 2 0 Occluded RNA-recognition motif ATG7_N PF16420.5 EWC46468.1 - 6.6e-103 344.5 0.0 8.7e-103 344.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EWC46468.1 - 7.9e-41 140.0 0.0 1.2e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 EWC46468.1 - 0.021 14.2 0.0 0.69 9.2 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FlaA PF04620.12 EWC46468.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Flagellar filament outer layer protein Flaa NACHT PF05729.12 EWC46469.1 - 3.1e-06 27.2 0.0 8.8e-06 25.7 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EWC46469.1 - 5.2e-05 23.7 0.1 0.00034 21.1 0.0 2.3 1 1 2 3 3 3 1 AAA ATPase domain NB-ARC PF00931.22 EWC46469.1 - 0.0013 18.0 0.0 0.0025 17.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_18 PF13238.6 EWC46469.1 - 0.013 16.1 0.0 0.062 13.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EWC46469.1 - 0.019 15.1 0.2 0.054 13.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EWC46469.1 - 0.029 14.3 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Helo_like_N PF17111.5 EWC46469.1 - 0.045 13.1 0.1 0.11 11.8 0.1 1.7 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins AAA_30 PF13604.6 EWC46469.1 - 0.084 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EWC46469.1 - 0.098 13.1 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 EWC46469.1 - 0.13 12.6 0.0 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EWC46469.1 - 0.15 12.5 0.1 0.53 10.7 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ribosomal_L18 PF17135.4 EWC46470.1 - 1.2e-91 305.2 2.8 1.4e-91 305.0 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EWC46470.1 - 0.0018 18.9 0.3 0.0018 18.9 0.3 2.2 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A ADC PF06314.11 EWC46471.1 - 0.00042 20.0 0.0 0.00069 19.3 0.0 1.3 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) TBCA PF02970.16 EWC46472.1 - 2.6e-24 85.4 9.2 2.6e-24 85.4 9.2 1.4 1 1 0 1 1 1 1 Tubulin binding cofactor A Spc7 PF08317.11 EWC46472.1 - 0.00019 20.4 6.1 0.00021 20.3 6.1 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein NifU_N PF01592.16 EWC46473.1 - 2.7e-44 150.4 0.2 2.9e-44 150.3 0.2 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EWC46473.1 - 0.032 14.5 0.1 0.064 13.5 0.1 1.5 1 0 0 1 1 1 0 TSCPD domain Mito_carr PF00153.27 EWC46474.1 - 8.3e-72 237.2 1.9 4.1e-24 84.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EWC46474.1 - 0.0024 17.1 0.2 0.17 11.0 0.0 3.0 2 1 1 3 3 3 2 Gammaproteobacterial serine protease Ppx-GppA PF02541.16 EWC46475.1 - 1.6e-43 149.2 0.0 2.4e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family DUF913 PF06025.12 EWC46475.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FtsA PF14450.6 EWC46475.1 - 0.14 12.6 0.0 25 5.4 0.0 3.0 2 2 0 2 2 2 0 Cell division protein FtsA GDA1_CD39 PF01150.17 EWC46475.1 - 0.26 9.9 0.1 0.59 8.7 0.1 1.5 2 0 0 2 2 2 0 GDA1/CD39 (nucleoside phosphatase) family UCH PF00443.29 EWC46476.1 - 1.1e-33 116.8 0.0 1.5e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EWC46476.1 - 1.4e-24 85.6 0.9 1e-23 82.9 0.0 2.4 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 EWC46476.1 - 2e-21 76.1 7.5 6.8e-18 64.8 2.3 2.9 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 EWC46476.1 - 6.1e-19 67.5 1.3 2.1e-10 40.3 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 EWC46476.1 - 4.2e-15 56.2 0.0 6.4e-07 29.3 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 EWC46476.1 - 0.003 17.3 0.0 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain DLH PF01738.18 EWC46477.1 - 6.1e-13 48.8 0.0 6.7e-11 42.1 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Hexokinase_2 PF03727.16 EWC46478.1 - 8.5e-83 277.5 0.0 1.2e-82 277.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EWC46478.1 - 6.8e-71 238.3 0.0 9.4e-71 237.8 0.0 1.2 1 0 0 1 1 1 1 Hexokinase IGR PF09597.10 EWC46478.1 - 0.12 12.4 0.3 2.5 8.3 0.0 2.4 2 0 0 2 2 2 0 IGR protein motif RRM_1 PF00076.22 EWC46479.1 - 2.1e-17 62.7 1.1 2.9e-17 62.2 0.4 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EWC46479.1 - 0.00014 21.4 0.1 0.00016 21.2 0.1 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC46479.1 - 0.0074 16.1 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Ribophorin_I PF04597.14 EWC46480.1 - 1.2e-144 482.8 0.0 1.4e-144 482.6 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I Indigoidine_A PF04227.12 EWC46481.1 - 4.3e-104 348.0 0.2 6.5e-104 347.4 0.2 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EWC46481.1 - 3.4e-18 66.0 1.4 1.3e-11 44.4 0.0 3.4 3 0 0 3 3 3 3 pfkB family carbohydrate kinase MSC PF09402.10 EWC46482.1 - 7.1e-96 321.6 0.6 9.5e-96 321.2 0.6 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EWC46482.1 - 2.7e-12 46.2 0.1 5.7e-12 45.1 0.1 1.6 1 0 0 1 1 1 1 HeH/LEM domain Endonuc-dimeris PF09124.10 EWC46482.1 - 0.049 13.8 0.0 0.2 11.8 0.1 2.0 2 0 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation Glyco_hydro_18 PF00704.28 EWC46483.1 - 2.1e-74 251.1 0.7 2.7e-74 250.7 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DNase_NucA_NucB PF14040.6 EWC46483.1 - 0.00052 20.4 0.2 0.0067 16.8 0.0 2.7 3 0 0 3 3 3 1 Deoxyribonuclease NucA/NucB LysM PF01476.20 EWC46485.1 - 1.9e-23 82.2 0.0 0.049 13.7 0.0 6.3 6 0 0 6 6 6 6 LysM domain PAN_4 PF14295.6 EWC46485.1 - 0.012 15.5 7.6 39 4.2 0.4 4.9 4 0 0 4 4 4 0 PAN domain RicinB_lectin_2 PF14200.6 EWC46485.1 - 0.03 15.0 0.0 1.1e+02 3.6 0.0 3.4 3 0 0 3 3 3 0 Ricin-type beta-trefoil lectin domain-like HSP20 PF00011.21 EWC46487.1 - 1.6e-17 63.5 0.4 2.1e-13 50.3 0.1 2.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EWC46487.1 - 9.8e-06 25.0 0.0 5.9e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA HTH_57 PF18679.1 EWC46487.1 - 0.19 12.0 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 ThcOx helix turn helix domain Rft-1 PF04506.13 EWC46488.1 - 7.8e-151 503.3 0.0 9e-151 503.1 0.0 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt PF01943.17 EWC46488.1 - 6.9e-05 22.4 15.7 0.0046 16.4 0.2 3.9 3 2 0 4 4 4 2 Polysaccharide biosynthesis protein Polysacc_synt_3 PF13440.6 EWC46488.1 - 0.0061 15.8 0.2 0.0061 15.8 0.2 2.4 3 0 0 3 3 3 1 Polysaccharide biosynthesis protein HAD_2 PF13419.6 EWC46489.1 - 5.2e-12 46.2 0.0 7.2e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EWC46489.1 - 1.2e-06 28.9 0.0 2.6e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EWC46489.1 - 1.8e-05 24.7 0.2 3.3e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DBD_Tnp_Hermes PF10683.9 EWC46489.1 - 0.059 13.1 0.4 0.11 12.2 0.4 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain PRKG1_interact PF15898.5 EWC46493.1 - 0.28 12.1 0.1 0.28 12.1 0.1 4.0 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF1515 PF07439.11 EWC46493.1 - 2.2 8.3 5.3 1.2 9.2 2.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) DUF4349 PF14257.6 EWC46493.1 - 3.6 7.0 18.5 0.28 10.6 6.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) CHAT PF12770.7 EWC46494.1 - 3.4e-33 115.3 0.0 5.7e-33 114.6 0.0 1.3 1 0 0 1 1 1 1 CHAT domain TPR_12 PF13424.6 EWC46494.1 - 6.9e-06 26.3 0.1 1.6 9.0 0.2 5.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EWC46494.1 - 5.1e-05 23.0 14.0 0.18 11.7 0.0 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46494.1 - 0.029 14.5 0.9 39 4.7 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF4404 PF14357.6 EWC46494.1 - 0.067 13.8 0.1 6.6 7.5 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) TPR_1 PF00515.28 EWC46494.1 - 0.26 11.2 3.5 5.3 7.0 0.0 4.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 EWC46495.1 - 2e-17 64.0 0.0 2.9e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Caspase domain PNP_UDP_1 PF01048.20 EWC46496.1 - 4.2e-10 39.3 0.1 1.3e-09 37.6 0.1 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily RrnaAD PF00398.20 EWC46497.1 - 2.9e-63 213.4 0.0 3.7e-63 213.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EWC46497.1 - 2.7e-07 31.2 0.0 6.3e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC46497.1 - 6e-05 23.6 0.0 0.00013 22.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EWC46497.1 - 0.00036 20.4 0.0 0.00064 19.5 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EWC46497.1 - 0.00075 19.4 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EWC46497.1 - 0.001 18.4 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EWC46497.1 - 0.0013 19.4 0.0 0.0029 18.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC46497.1 - 0.0048 16.7 0.0 0.0077 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EWC46497.1 - 0.0051 16.4 0.0 0.0084 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EWC46497.1 - 0.0081 15.5 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Met_10 PF02475.16 EWC46497.1 - 0.024 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_28 PF02636.17 EWC46497.1 - 0.046 13.4 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.18 EWC46497.1 - 0.12 11.6 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain DREV PF05219.12 EWC46497.1 - 0.12 11.4 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase PRP1_N PF06424.12 EWC46498.1 - 7.3e-52 175.7 7.4 1.9e-51 174.4 7.4 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EWC46498.1 - 7.4e-25 85.5 37.2 0.0014 19.2 0.1 13.7 5 3 9 14 14 13 10 Tetratricopeptide repeat TPR_19 PF14559.6 EWC46498.1 - 4e-23 81.7 17.3 4.6e-05 23.9 0.3 10.4 6 3 4 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46498.1 - 6.2e-08 32.2 14.4 0.75 10.1 0.0 9.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 EWC46498.1 - 0.0012 18.8 8.6 2.8 8.4 0.0 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EWC46498.1 - 0.0013 19.0 7.8 1.3e+02 3.4 0.1 8.5 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_16 PF13432.6 EWC46498.1 - 0.0016 19.0 40.6 1.6 9.4 1.0 8.1 5 2 3 9 9 8 4 Tetratricopeptide repeat NARP1 PF12569.8 EWC46498.1 - 0.0021 17.0 7.2 0.032 13.2 0.0 4.0 3 1 1 4 4 4 2 NMDA receptor-regulated protein 1 TPR_1 PF00515.28 EWC46498.1 - 0.005 16.6 1.2 0.83 9.6 0.1 3.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Suf PF05843.14 EWC46498.1 - 0.091 12.7 3.1 2.2 8.2 0.3 3.7 2 1 0 2 2 2 0 Suppressor of forked protein (Suf) TPR_9 PF13371.6 EWC46498.1 - 1.1 9.4 15.4 4.1 7.6 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat Galactosyl_T PF01762.21 EWC46499.1 - 0.051 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Galactosyltransferase dCMP_cyt_deam_1 PF00383.23 EWC46500.1 - 9.6e-19 67.1 0.0 1.4e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EWC46500.1 - 1.2e-05 25.0 0.0 1.7e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 EWC46500.1 - 0.0064 17.0 0.3 0.021 15.4 0.1 2.1 2 1 0 2 2 2 1 AAA domain CoaE PF01121.20 EWC46500.1 - 0.092 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase S4 PF01479.25 EWC46501.1 - 8.2e-13 47.9 0.0 1.5e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EWC46501.1 - 3.7e-11 43.8 0.8 5.8e-11 43.2 0.7 1.4 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain GlutR_dimer PF00745.20 EWC46501.1 - 0.11 13.0 0.1 0.45 11.0 0.0 2.0 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain ADP_ribosyl_GH PF03747.14 EWC46502.1 - 2.3e-55 188.4 0.4 2.9e-55 188.0 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Gly-zipper_Omp PF13488.6 EWC46502.1 - 0.042 13.8 3.6 0.72 9.9 2.3 2.5 2 0 0 2 2 2 0 Glycine zipper PheRS_DBD1 PF18552.1 EWC46502.1 - 0.16 11.7 0.2 0.63 9.8 0.1 1.9 2 0 0 2 2 2 0 PheRS DNA binding domain 1 Rick_17kDa_Anti PF05433.15 EWC46502.1 - 4.3 7.3 9.8 0.11 12.4 2.2 2.1 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 EWC46502.1 - 5.9 6.7 8.1 9 6.1 4.8 2.4 2 0 0 2 2 2 0 YMGG-like Gly-zipper TRP PF06011.12 EWC46503.1 - 5.2e-131 437.3 16.5 6.7e-131 436.9 16.5 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EWC46503.1 - 2.6e-36 125.1 0.0 3.9e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 ML-like domain DUF1180 PF06679.12 EWC46503.1 - 0.15 12.5 0.1 4.3 7.7 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF3810 PF12725.7 EWC46503.1 - 4.9 6.4 8.1 11 5.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DWNN PF08783.11 EWC46504.1 - 6e-28 96.9 0.0 1.1e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EWC46504.1 - 9.8e-09 34.9 5.6 1.7e-08 34.1 5.6 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EWC46504.1 - 3.7e-05 23.6 1.6 3.7e-05 23.6 1.6 1.7 2 0 0 2 2 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 EWC46504.1 - 0.0011 18.7 7.8 0.0011 18.7 7.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC_3 PF13917.6 EWC46504.1 - 0.0019 18.1 0.5 0.0053 16.7 0.5 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-RING_2 PF13639.6 EWC46504.1 - 0.017 15.5 5.7 0.039 14.3 5.7 1.7 1 0 0 1 1 1 0 Ring finger domain U-box PF04564.15 EWC46504.1 - 0.017 15.3 0.0 0.041 14.0 0.0 1.7 1 0 0 1 1 1 0 U-box domain zf-CCHC_5 PF14787.6 EWC46504.1 - 0.051 13.3 0.2 0.051 13.3 0.2 1.9 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-C3HC4 PF00097.25 EWC46504.1 - 1.8 8.5 7.9 3.8 7.5 7.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC46504.1 - 2.6 8.1 12.1 0.21 11.6 6.0 2.1 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EWC46504.1 - 5.6 6.9 11.9 0.6 10.0 5.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EWC46504.1 - 8.2 6.7 8.3 19 5.5 8.3 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Dsh_C PF12316.8 EWC46505.1 - 0.0061 17.0 3.7 0.01 16.2 3.7 1.4 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal DUF3682 PF12446.8 EWC46505.1 - 0.1 13.1 6.7 0.24 11.9 6.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) FAM199X PF15814.5 EWC46505.1 - 0.2 10.7 3.2 0.3 10.1 3.2 1.2 1 0 0 1 1 1 0 Protein family FAM199X Vac7 PF12751.7 EWC46506.1 - 3.6e-83 280.1 4.0 3.6e-83 280.1 4.0 2.4 1 1 1 2 2 2 1 Vacuolar segregation subunit 7 Protoglobin PF11563.8 EWC46507.1 - 2.8e-49 167.1 0.0 3.3e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 Protoglobin Pkinase PF00069.25 EWC46508.1 - 1.3e-45 155.8 0.0 2e-44 151.9 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46508.1 - 8.6e-29 100.6 0.0 1.8e-28 99.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC46508.1 - 0.0092 14.8 0.1 0.29 9.9 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EWC46508.1 - 0.15 11.0 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase WD40 PF00400.32 EWC46509.1 - 1.3e-38 130.3 19.1 6.3e-06 26.8 0.3 11.3 10 1 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC46509.1 - 1.7e-22 79.5 0.1 1.5e-06 28.4 0.0 7.6 3 3 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EWC46509.1 - 0.00025 20.9 0.4 4.4 7.4 0.0 5.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat RAB3GAP2_N PF14655.6 EWC46509.1 - 0.00047 19.5 0.1 0.0026 17.1 0.0 2.1 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Frtz PF11768.8 EWC46509.1 - 0.0015 16.9 0.0 0.81 7.9 0.0 3.0 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Ricin_B_lectin PF00652.22 EWC46509.1 - 0.019 15.2 0.1 0.26 11.5 0.2 2.7 3 0 0 3 3 3 0 Ricin-type beta-trefoil lectin domain Str_synth PF03088.16 EWC46509.1 - 0.14 12.3 0.0 18 5.5 0.0 3.5 3 1 1 4 4 4 0 Strictosidine synthase PKD PF00801.20 EWC46509.1 - 6.5 6.7 9.2 10 6.0 0.3 3.8 4 0 0 4 4 4 0 PKD domain DUF4226 PF10774.9 EWC46510.1 - 0.029 14.7 1.6 0.08 13.2 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4226) FliJ PF02050.16 EWC46510.1 - 0.13 12.5 2.0 1.7 8.9 0.9 2.6 2 0 0 2 2 2 0 Flagellar FliJ protein Kre28 PF17097.5 EWC46510.1 - 0.18 10.7 2.3 0.46 9.4 0.3 2.1 2 0 0 2 2 2 0 Spindle pole body component HalX PF08663.10 EWC46510.1 - 5.2 7.5 7.6 1.9 8.9 3.2 2.6 2 0 0 2 2 2 0 HalX domain FtsJ PF01728.19 EWC46511.1 - 2.3e-51 174.4 0.0 3e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Filament PF00038.21 EWC46512.1 - 0.00013 21.7 76.4 0.0032 17.1 46.4 3.2 1 1 2 3 3 3 2 Intermediate filament protein CALCOCO1 PF07888.11 EWC46512.1 - 0.00043 19.3 46.4 0.00043 19.3 46.4 4.0 1 1 3 4 4 4 2 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.9 EWC46512.1 - 0.00051 20.1 27.0 0.00051 20.1 27.0 5.4 1 1 5 6 6 6 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EWC46512.1 - 0.0014 18.7 27.8 0.0014 18.7 27.8 5.6 1 1 3 5 5 5 3 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EWC46512.1 - 0.0017 17.3 29.0 0.0017 17.3 29.0 4.1 1 1 2 3 3 3 1 Spc7 kinetochore protein EzrA PF06160.12 EWC46512.1 - 0.0022 16.3 11.8 0.0022 16.3 11.8 2.4 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA Fez1 PF06818.15 EWC46512.1 - 0.0032 17.9 77.1 1 9.8 45.0 4.4 1 1 2 3 3 3 2 Fez1 DUF745 PF05335.13 EWC46512.1 - 0.023 14.4 56.3 0.013 15.3 18.5 3.8 1 1 1 3 3 3 0 Protein of unknown function (DUF745) TolA_bind_tri PF16331.5 EWC46512.1 - 0.023 14.7 2.4 0.023 14.7 2.4 7.2 2 1 4 6 6 6 0 TolA binding protein trimerisation LPP PF04728.13 EWC46512.1 - 0.033 14.6 2.2 0.033 14.6 2.2 7.1 6 2 2 8 8 8 0 Lipoprotein leucine-zipper FliJ PF02050.16 EWC46512.1 - 0.21 11.8 61.9 0.12 12.6 7.6 4.7 2 1 2 4 4 4 0 Flagellar FliJ protein GAS PF13851.6 EWC46512.1 - 0.65 9.3 86.2 0.018 14.4 12.0 5.7 1 1 4 5 5 5 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 EWC46512.1 - 3.1 7.8 53.5 0.49 10.4 13.3 5.1 1 1 5 6 6 6 0 Laminin Domain II DUF1664 PF07889.12 EWC46512.1 - 9.8 6.2 44.1 1.9 8.6 2.0 5.0 1 1 1 4 4 4 0 Protein of unknown function (DUF1664) OST3_OST6 PF04756.13 EWC46513.1 - 1.4e-102 343.0 0.5 1.6e-102 342.8 0.5 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Use1 PF09753.9 EWC46513.1 - 0.2 11.3 2.1 0.29 10.8 2.1 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 SAGA-Tad1 PF12767.7 EWC46514.1 - 9.8e-47 159.7 0.0 1.4e-46 159.1 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit SNF2_N PF00176.23 EWC46515.1 - 5.2e-66 222.8 0.0 1.1e-65 221.7 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC46515.1 - 6.1e-18 65.2 0.0 1.9e-17 63.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC46515.1 - 3.2e-12 46.8 0.0 1.6e-11 44.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EWC46515.1 - 0.00052 19.8 0.0 0.0028 17.4 0.0 2.2 1 1 0 1 1 1 1 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 EWC46515.1 - 0.0014 17.9 0.0 0.0014 17.9 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase FCD PF07729.12 EWC46515.1 - 0.12 12.8 0.0 0.12 12.8 0.0 2.4 3 0 0 3 3 3 0 FCD domain Spc7 PF08317.11 EWC46515.1 - 0.76 8.6 7.4 2.1 7.1 7.4 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein FUSC_2 PF13515.6 EWC46516.1 - 7.8e-27 93.9 3.9 7.8e-27 93.9 3.9 2.4 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EWC46516.1 - 1.6e-11 44.5 0.2 3.7e-10 40.0 0.0 2.2 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC PF04632.12 EWC46516.1 - 6.2e-11 41.6 0.1 6.2e-11 41.6 0.1 2.7 3 1 1 4 4 4 1 Fusaric acid resistance protein family ALMT PF11744.8 EWC46516.1 - 3.4e-07 29.5 14.1 5.4e-05 22.2 9.4 3.5 3 1 0 3 3 3 2 Aluminium activated malate transporter Aminotran_1_2 PF00155.21 EWC46517.1 - 8.6e-36 123.9 0.0 1.1e-35 123.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Sua5_yciO_yrdC PF01300.18 EWC46517.1 - 0.21 11.1 0.0 0.4 10.1 0.0 1.5 1 0 0 1 1 1 0 Telomere recombination DUF727 PF05303.12 EWC46518.1 - 9.4e-12 44.9 0.0 1.2e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF727) DUF3150 PF11348.8 EWC46518.1 - 0.018 14.3 0.0 0.023 13.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) DUF1489 PF07370.11 EWC46518.1 - 0.049 13.4 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) MVP_shoulder PF11978.8 EWC46518.1 - 0.16 12.0 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Shoulder domain His_biosynth PF00977.21 EWC46520.1 - 2.4e-48 164.6 0.2 1.5e-47 162.0 0.2 2.3 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EWC46520.1 - 3.9e-20 72.4 0.0 6.6e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EWC46520.1 - 4.1e-09 36.6 0.0 7.1e-06 26.0 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EWC46520.1 - 1e-05 25.3 0.0 2.8e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EWC46520.1 - 0.05 13.4 0.0 0.14 11.9 0.0 1.7 1 1 0 1 1 1 0 Peptidase C26 DUF5334 PF17268.2 EWC46520.1 - 0.16 12.3 0.7 0.65 10.3 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5334) Peptidase_S8 PF00082.22 EWC46521.1 - 8.6e-30 104.0 0.9 1.7e-29 103.0 0.9 1.4 1 1 0 1 1 1 1 Subtilase family PEPCK_GTP PF00821.18 EWC46521.1 - 0.2 10.5 0.1 0.35 9.6 0.1 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain ODC_AZ PF02100.17 EWC46522.1 - 1.1e-37 128.4 0.0 2e-37 127.7 0.0 1.4 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Ribosomal_L7Ae PF01248.26 EWC46523.1 - 2e-24 85.1 0.0 2.3e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L16 PF00252.18 EWC46524.1 - 4.3e-44 149.7 0.0 5.4e-44 149.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF2196 PF09962.9 EWC46525.1 - 1.5e-21 76.1 3.4 2.9e-21 75.2 3.4 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) OB_NTP_bind PF07717.16 EWC46526.1 - 1.6e-23 82.8 0.0 5.5e-23 81.1 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EWC46526.1 - 5.4e-20 71.7 0.0 5.4e-20 71.7 0.0 4.7 6 1 0 6 6 5 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EWC46526.1 - 7.4e-14 52.0 0.5 2.3e-13 50.4 0.0 2.1 2 0 0 2 2 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EWC46526.1 - 3e-05 24.3 4.4 0.00041 20.6 0.0 3.4 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 EWC46526.1 - 3.5e-05 23.6 0.0 9.6e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EWC46526.1 - 0.00043 20.1 0.1 0.0012 18.6 0.1 1.7 1 0 0 1 1 1 1 AAA domain PWI PF01480.17 EWC46526.1 - 0.0019 18.5 0.0 0.0046 17.2 0.0 1.7 1 0 0 1 1 1 1 PWI domain AAA_19 PF13245.6 EWC46526.1 - 0.003 17.9 0.1 0.0082 16.5 0.1 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EWC46526.1 - 0.0035 16.4 0.0 0.0091 15.1 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein PsbU PF06514.11 EWC46526.1 - 0.027 14.4 0.1 13 5.8 0.0 2.8 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) AAA_7 PF12775.7 EWC46526.1 - 0.05 13.1 0.6 0.48 9.9 0.0 2.3 1 1 1 2 2 2 0 P-loop containing dynein motor region SRP54 PF00448.22 EWC46526.1 - 0.083 12.5 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EWC46526.1 - 0.2 12.2 1.3 0.48 10.9 0.0 2.4 2 1 0 2 2 2 0 ABC transporter Roc PF08477.13 EWC46526.1 - 4.7 7.5 5.2 0.84 9.9 0.0 2.4 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase SIS PF01380.22 EWC46527.1 - 1.8e-11 44.0 0.7 5.9e-11 42.3 0.7 1.9 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EWC46527.1 - 1.3e-05 25.2 1.9 0.0003 20.8 0.2 2.4 1 1 1 2 2 2 2 SIS domain DUF2529 PF10740.9 EWC46527.1 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2529) HTH_psq PF05225.16 EWC46527.1 - 0.46 10.3 4.1 1.6 8.5 0.1 2.7 2 1 1 3 3 3 0 helix-turn-helix, Psq domain SDA1 PF05285.12 EWC46528.1 - 0.007 15.8 7.2 0.013 14.9 7.2 1.4 1 0 0 1 1 1 1 SDA1 CAF1A PF12253.8 EWC46528.1 - 0.093 12.9 17.7 0.25 11.5 17.7 1.7 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Nop14 PF04147.12 EWC46528.1 - 0.1 10.8 8.3 0.16 10.2 8.3 1.3 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EWC46528.1 - 0.33 9.0 17.7 0.48 8.5 17.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 EWC46528.1 - 2 6.6 8.1 3.4 5.8 8.1 1.3 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EWC46528.1 - 2.8 7.2 17.0 6.1 6.1 17.0 1.5 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 EWC46528.1 - 3 7.9 7.8 7.8 6.5 7.8 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal PPP4R2 PF09184.11 EWC46528.1 - 6.2 6.3 12.6 16 5.0 12.6 1.7 1 0 0 1 1 1 0 PPP4R2 Yippee-Mis18 PF03226.14 EWC46529.1 - 1.1e-19 70.6 0.1 2e-19 69.8 0.1 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EWC46529.1 - 0.021 15.1 0.3 0.046 13.9 0.3 1.5 1 1 0 1 1 1 0 C-terminal domain of RIG-I acVLRF1 PF18859.1 EWC46529.1 - 0.33 11.2 6.5 0.46 10.8 0.4 2.3 2 0 0 2 2 2 0 Actinobacteria/chloroflexi VLRF1 release factor SHNi-TPR PF10516.9 EWC46530.1 - 5.6e-14 51.3 1.1 9.7e-14 50.5 0.3 1.9 2 0 0 2 2 2 1 SHNi-TPR Tom5 PF10642.9 EWC46530.1 - 0.068 13.2 0.0 0.068 13.2 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial import receptor subunit or translocase V-SNARE PF05008.15 EWC46530.1 - 1.5 9.2 9.9 0.66 10.4 0.1 3.5 4 0 0 4 4 4 0 Vesicle transport v-SNARE protein N-terminus RRM_1 PF00076.22 EWC46531.1 - 2.1e-33 113.9 0.1 5.8e-16 58.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EWC46531.1 - 8.8e-11 41.8 0.0 0.00052 20.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EWC46531.1 - 0.00083 19.3 0.0 0.6 10.2 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif MCRS_N PF13325.6 EWC46531.1 - 0.39 10.7 1.8 0.65 10.0 1.8 1.3 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein RabGAP-TBC PF00566.18 EWC46532.1 - 9.4e-56 188.9 0.0 1.3e-55 188.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1771 PF08590.10 EWC46532.1 - 0.034 14.5 0.3 0.065 13.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) Ribosomal_S18 PF01084.20 EWC46533.1 - 1.5e-16 60.4 0.0 5.5e-16 58.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S18 PPR_2 PF13041.6 EWC46534.1 - 4.5e-12 46.0 3.1 0.12 12.6 0.2 5.9 5 0 0 5 5 5 4 PPR repeat family PPR_3 PF13812.6 EWC46534.1 - 1.4e-06 28.2 0.0 0.017 15.2 0.0 3.6 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR PF01535.20 EWC46534.1 - 0.00014 21.9 3.7 0.48 10.8 0.3 4.3 5 0 0 5 5 5 2 PPR repeat ATP13 PF12921.7 EWC46534.1 - 0.016 15.1 0.0 9.2 6.2 0.0 3.3 3 0 0 3 3 3 0 Mitochondrial ATPase expression PPR_1 PF12854.7 EWC46534.1 - 0.22 11.3 1.4 8.3 6.2 0.1 3.0 3 0 0 3 3 3 0 PPR repeat Cyt-b5 PF00173.28 EWC46535.1 - 8.6e-21 73.9 0.1 9.6e-21 73.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain V-ATPase_H_C PF11698.8 EWC46535.1 - 0.039 14.1 0.0 0.071 13.2 0.0 1.5 1 1 0 1 1 1 0 V-ATPase subunit H EFP_N PF08207.12 EWC46535.1 - 0.041 13.9 0.1 0.064 13.3 0.1 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain SWIM PF04434.17 EWC46536.1 - 0.058 13.1 0.7 4.2 7.1 0.3 2.4 2 0 0 2 2 2 0 SWIM zinc finger DUF5001 PF16392.5 EWC46538.1 - 0.015 15.2 0.1 2.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Ig-like domain CorA PF01544.18 EWC46539.1 - 0.0015 18.0 2.3 0.0028 17.0 0.3 2.1 1 1 1 2 2 2 1 CorA-like Mg2+ transporter protein DUF1043 PF06295.12 EWC46539.1 - 1.1 9.3 4.1 0.62 10.1 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Pkinase PF00069.25 EWC46540.1 - 8.9e-31 107.2 0.1 2.7e-29 102.3 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46540.1 - 1.4e-24 86.8 0.0 1.2e-22 80.5 0.0 2.8 2 2 0 2 2 2 2 Protein tyrosine kinase Choline_kinase PF01633.20 EWC46540.1 - 0.013 15.1 0.0 0.035 13.7 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 EWC46540.1 - 0.034 14.1 0.0 0.27 11.1 0.1 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family DNA_pol_B PF00136.21 EWC46541.1 - 1.5e-147 492.1 1.5 2.2e-147 491.5 1.5 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EWC46541.1 - 2.2e-77 260.5 0.0 4.4e-77 259.5 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EWC46541.1 - 2.8e-18 66.2 8.5 7.1e-18 64.8 8.5 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.9 EWC46541.1 - 0.00034 20.4 0.0 0.00075 19.2 0.0 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA_pol_B_2 PF03175.13 EWC46541.1 - 0.00082 18.3 0.9 0.0083 15.0 0.0 2.7 3 0 0 3 3 3 1 DNA polymerase type B, organellar and viral DUF2614 PF11023.8 EWC46541.1 - 0.024 14.7 0.2 0.051 13.7 0.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon containing domain F-box PF00646.33 EWC46542.1 - 1.2e-07 31.4 0.4 2.3e-07 30.5 0.4 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EWC46542.1 - 0.0028 17.5 0.3 0.0069 16.3 0.3 1.7 1 0 0 1 1 1 1 F-box-like Zip PF02535.22 EWC46543.1 - 1.9e-64 218.0 10.6 2.2e-64 217.8 10.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter GFO_IDH_MocA PF01408.22 EWC46544.1 - 8.7e-11 42.7 0.2 5.2e-10 40.2 0.2 2.1 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold AMP-binding PF00501.28 EWC46544.1 - 1.7e-05 23.6 0.0 2.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme LigB PF02900.18 EWC46544.1 - 0.0064 15.6 0.2 0.011 14.8 0.2 1.3 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DHDPS PF00701.22 EWC46545.1 - 8e-37 126.5 0.0 9.8e-37 126.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Clr5 PF14420.6 EWC46547.1 - 1.3e-18 67.0 0.7 2.6e-18 66.0 0.7 1.6 1 0 0 1 1 1 1 Clr5 domain Ank_4 PF13637.6 EWC46547.1 - 3.8e-05 24.1 0.0 0.32 11.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EWC46547.1 - 4.6e-05 23.6 0.0 0.00035 20.8 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EWC46547.1 - 0.0022 18.6 0.0 0.24 12.0 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EWC46547.1 - 0.017 15.6 0.0 0.37 11.3 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Glyco_hydro_3_C PF01915.22 EWC46548.1 - 5.8e-49 166.8 0.0 9.3e-49 166.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EWC46548.1 - 3.2e-32 112.2 0.0 7.9e-32 110.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EWC46548.1 - 4.3e-17 62.0 0.8 8.7e-17 61.0 0.8 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Fungal_trans PF04082.18 EWC46549.1 - 8.3e-39 133.2 0.0 1.4e-38 132.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC46549.1 - 8.4e-10 38.6 8.0 1.9e-09 37.5 8.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cyanate_lyase PF02560.14 EWC46554.1 - 4.2e-32 109.8 0.0 5.6e-32 109.4 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 EWC46554.1 - 0.0007 19.9 0.2 0.0012 19.2 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain bPH_6 PF10756.9 EWC46554.1 - 0.072 13.2 0.0 5.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial PH domain HTH_3 PF01381.22 EWC46554.1 - 0.15 12.1 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix 2OG-FeII_Oxy PF03171.20 EWC46555.1 - 3.1e-15 56.5 0.0 6.5e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EWC46555.1 - 8e-14 52.4 1.3 8.5e-14 52.3 0.1 1.6 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal PLDc_2 PF13091.6 EWC46556.1 - 1.4e-15 57.3 0.0 1.7e-05 24.7 0.0 3.5 3 0 0 3 3 3 3 PLD-like domain PLDc PF00614.22 EWC46556.1 - 1.7e-10 40.6 2.2 0.00016 21.7 0.2 2.9 3 0 0 3 3 3 2 Phospholipase D Active site motif Zn_clus PF00172.18 EWC46558.1 - 1.3e-08 34.8 9.4 2.2e-08 34.1 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EWC46558.1 - 0.0019 17.3 5.8 0.0026 16.9 4.7 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain Glyco_hydro_3_C PF01915.22 EWC46559.1 - 1.1e-61 208.4 0.0 2.3e-61 207.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EWC46559.1 - 1.1e-46 159.7 0.0 6.1e-46 157.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EWC46559.1 - 2.4e-27 94.8 2.4 6.7e-27 93.4 2.4 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EWC46559.1 - 7e-11 42.1 0.0 1.4e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 PA14 domain CARDB PF07705.11 EWC46559.1 - 0.00029 21.1 1.0 0.00091 19.5 0.6 2.1 2 0 0 2 2 2 1 CARDB GLEYA PF10528.9 EWC46559.1 - 0.02 15.3 0.0 0.093 13.2 0.0 2.1 2 0 0 2 2 2 0 GLEYA domain MDMPI_C PF07398.11 EWC46559.1 - 0.39 11.6 1.8 0.71 10.8 0.3 2.2 2 0 0 2 2 2 0 MDMPI C-terminal domain Band_7 PF01145.25 EWC46561.1 - 5.1e-17 62.4 0.2 5.1e-17 62.4 0.2 2.9 2 1 0 3 3 3 1 SPFH domain / Band 7 family Cupin_8 PF13621.6 EWC46561.1 - 5.3 6.7 5.4 7.7 6.1 4.8 1.5 1 1 0 1 1 1 0 Cupin-like domain Glyco_hydro_3_C PF01915.22 EWC46562.1 - 1.1e-56 192.1 0.0 1.6e-56 191.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EWC46562.1 - 1.2e-49 169.4 0.0 2e-49 168.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EWC46562.1 - 2.4e-18 66.0 0.1 7e-18 64.5 0.1 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EWC46562.1 - 1.3e-11 44.5 0.0 2.3e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 EWC46562.1 - 0.079 13.4 0.0 0.48 10.9 0.0 2.2 2 0 0 2 2 2 0 GLEYA domain Zn_clus PF00172.18 EWC46563.1 - 5.6e-10 39.2 10.5 1.4e-09 38.0 10.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ThiJ_like PF17124.5 EWC46564.1 - 4.5e-35 121.1 0.1 1.1e-32 113.4 0.1 2.9 1 1 0 1 1 1 1 ThiJ/PfpI family-like TMEM51 PF15345.6 EWC46564.1 - 0.055 13.3 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Methyltransf_25 PF13649.6 EWC46565.1 - 0.0015 19.2 0.0 0.0039 17.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC46565.1 - 0.009 15.9 0.0 0.03 14.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DNA_methylase PF00145.17 EWC46566.1 - 5.4e-15 55.6 0.0 1.2e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase SNF2_N PF00176.23 EWC46566.1 - 7.4e-15 54.5 0.0 3.1e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC46566.1 - 2.5e-05 24.6 0.0 6e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EWC46566.1 - 0.0026 17.6 9.5 0.0099 15.7 0.7 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EWC46566.1 - 0.0027 17.7 0.0 0.0092 16.0 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit IBR PF01485.21 EWC46566.1 - 5 7.4 10.4 2 8.7 2.2 2.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Vps62 PF06101.11 EWC46568.1 - 3.7e-11 42.1 2.4 7.9e-11 41.0 0.7 2.0 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 2Fe-2S_thioredx PF01257.19 EWC46569.1 - 6.1e-59 198.0 0.0 7.6e-59 197.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin POM121 PF15229.6 EWC46569.1 - 0.37 10.4 3.1 4.5 6.8 0.1 2.1 2 0 0 2 2 2 0 POM121 family TFIIIC_sub6 PF10419.9 EWC46570.1 - 2.5e-21 75.3 0.0 3.8e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain DnaJ_C PF01556.18 EWC46571.1 - 2e-29 102.6 0.0 2.9e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EWC46571.1 - 7.7e-25 86.8 4.8 1.3e-24 86.0 4.8 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EWC46571.1 - 5.4e-14 52.3 15.5 1.1e-13 51.4 15.5 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EWC46571.1 - 0.00076 19.4 9.8 0.15 12.1 0.6 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EWC46571.1 - 0.06 13.4 7.5 0.22 11.5 0.5 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 EWC46571.1 - 2.2 7.9 8.2 0.72 9.5 0.7 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 EWC46571.1 - 7.7 6.6 10.1 43 4.2 10.1 2.0 1 1 0 1 1 1 0 Double zinc ribbon DUF1258 PF06869.12 EWC46571.1 - 7.9 5.9 9.2 11 5.4 6.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1258) PARP PF00644.20 EWC46572.1 - 7.2e-57 192.1 7.5 1.1e-56 191.5 0.0 3.2 3 1 1 4 4 4 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EWC46572.1 - 9.8e-40 135.8 0.7 1.8e-39 135.0 0.7 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EWC46572.1 - 9.7e-24 83.2 1.3 2.9e-23 81.7 1.3 1.9 1 0 0 1 1 1 1 WGR domain BRCT PF00533.26 EWC46572.1 - 1.1e-12 48.1 0.0 2.3e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EWC46572.1 - 2.7e-08 34.1 0.0 6e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EWC46572.1 - 8.5e-06 25.6 0.0 2.1e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 EWC46572.1 - 0.006 16.8 0.1 0.018 15.3 0.1 1.8 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain CDC27 PF09507.10 EWC46572.1 - 0.082 12.3 35.9 0.16 11.3 35.9 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Lactonase PF10282.9 EWC46573.1 - 9.7e-70 235.5 0.0 1.1e-69 235.3 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.20 EWC46573.1 - 0.00039 20.5 0.1 0.29 11.4 0.0 3.1 3 0 0 3 3 3 2 Arylesterase DUF1223 PF06764.11 EWC46574.1 - 1.6e-54 185.1 0.0 2.1e-54 184.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1223) Thioredoxin_4 PF13462.6 EWC46574.1 - 0.24 11.6 0.0 3.9 7.6 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin IlvC PF01450.19 EWC46575.1 - 2.5e-41 141.3 0.0 3.9e-41 140.7 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvN PF07991.12 EWC46575.1 - 2.3e-27 95.6 0.0 4.1e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain UQ_con PF00179.26 EWC46576.1 - 3e-39 133.9 0.0 3.7e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EWC46576.1 - 0.021 14.5 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 EWC46576.1 - 0.069 13.0 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 UEV domain N_BRCA1_IG PF16158.5 EWC46577.1 - 1.3e-29 102.9 0.8 5.8e-29 100.8 0.1 2.4 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EWC46577.1 - 6.9e-18 64.2 58.9 4.3e-08 32.9 4.7 4.4 4 0 0 4 4 4 4 Zinc finger, ZZ type C1_2 PF03107.16 EWC46577.1 - 0.01 16.1 9.2 0.01 16.1 9.2 4.7 4 0 0 4 4 4 0 C1 domain WH2 PF02205.20 EWC46577.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 WH2 motif DEAD PF00270.29 EWC46579.1 - 2.8e-32 111.9 0.0 4.9e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC46579.1 - 8.9e-24 84.0 0.1 1.9e-23 82.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain FCH PF00611.23 EWC46580.1 - 3.7e-24 84.8 1.3 1.1e-21 76.9 0.1 3.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 EWC46580.1 - 1.5e-18 66.4 0.6 2.3e-10 40.2 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EWC46580.1 - 2.1e-17 62.4 0.6 6.4e-08 32.1 0.2 2.5 2 0 0 2 2 2 2 SH3 domain C1_1 PF00130.22 EWC46580.1 - 2.7e-14 52.8 7.0 5.2e-14 51.9 7.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.17 EWC46580.1 - 0.00064 19.3 0.1 0.73 9.6 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain STAT_alpha PF01017.20 EWC46580.1 - 0.0088 15.9 0.7 0.0088 15.9 0.7 2.1 2 1 0 2 2 2 1 STAT protein, all-alpha domain SH3_10 PF17902.1 EWC46580.1 - 0.0091 16.1 0.0 0.17 12.0 0.0 2.6 2 0 0 2 2 2 1 SH3 domain DUF922 PF06037.11 EWC46580.1 - 0.067 13.0 0.5 0.21 11.4 0.5 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) SH3_3 PF08239.11 EWC46580.1 - 0.16 12.3 0.9 5 7.5 0.2 2.4 2 0 0 2 2 2 0 Bacterial SH3 domain C1_2 PF03107.16 EWC46580.1 - 0.69 10.3 6.6 1.2 9.5 6.6 1.4 1 0 0 1 1 1 0 C1 domain FapA PF03961.13 EWC46580.1 - 1.8 7.0 6.7 0.98 8.0 0.5 2.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A IFRD PF05004.13 EWC46581.1 - 8.6e-68 228.7 0.1 1.1e-67 228.3 0.1 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) GRIN_C PF15235.6 EWC46581.1 - 0.14 12.4 1.3 6.4 7.0 0.3 2.3 2 0 0 2 2 2 0 G protein-regulated inducer of neurite outgrowth C-terminus RAP1 PF07218.11 EWC46581.1 - 9.8 4.3 5.4 14 3.8 5.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DEAD PF00270.29 EWC46582.1 - 5e-48 163.2 0.0 9.5e-48 162.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC46582.1 - 2.4e-23 82.6 0.0 1.9e-22 79.7 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EWC46582.1 - 3.4e-19 68.8 0.1 7.2e-19 67.8 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EWC46582.1 - 6.8e-06 26.2 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EWC46582.1 - 0.0017 17.7 0.0 0.0036 16.6 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Med19 PF10278.9 EWC46582.1 - 2.9 7.8 9.5 5.5 6.9 9.5 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TRP PF06011.12 EWC46583.1 - 3e-155 517.2 32.7 4.4e-155 516.6 32.7 1.3 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EWC46583.1 - 4e-35 121.2 0.1 6.3e-35 120.6 0.1 1.3 1 0 0 1 1 1 1 ML-like domain DUF4389 PF14333.6 EWC46583.1 - 0.006 16.5 0.2 0.006 16.5 0.2 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4389) Sigma_reg_N PF13800.6 EWC46583.1 - 0.24 11.7 0.0 0.24 11.7 0.0 3.9 4 0 0 4 4 4 0 Sigma factor regulator N-terminal FAD_binding_4 PF01565.23 EWC46584.1 - 7.5e-14 51.6 0.1 1.3e-13 50.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF4304 PF14137.6 EWC46584.1 - 0.12 12.6 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4304) RRM_1 PF00076.22 EWC46585.1 - 6.5e-10 38.7 0.1 1.4e-09 37.6 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EWC46585.1 - 0.0011 18.5 0.1 0.0027 17.3 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.21 EWC46586.1 - 2.4e-46 157.9 0.1 4.3e-46 157.1 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Tfb5 PF06331.12 EWC46586.1 - 3.4e-13 49.4 2.5 9e-13 48.0 2.5 1.6 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 TPR_1 PF00515.28 EWC46586.1 - 3.4e-05 23.5 2.0 3.8 7.5 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46586.1 - 0.00015 21.6 1.1 0.49 10.6 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EWC46586.1 - 0.027 14.1 0.3 2.3 8.0 0.0 2.5 2 0 0 2 2 2 0 TPR repeat TPR_9 PF13371.6 EWC46586.1 - 0.11 12.7 0.0 3.9 7.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_29 PF13555.6 EWC46586.1 - 0.16 11.7 0.0 21 4.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Tyr_Deacylase PF02580.16 EWC46587.1 - 1.6e-33 116.3 0.0 1.9e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Not3 PF04065.15 EWC46588.1 - 4.4e-92 307.7 24.3 7.2e-92 307.0 24.3 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EWC46588.1 - 2e-43 147.6 10.5 2e-43 147.6 10.5 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.9 EWC46588.1 - 0.0065 16.3 4.8 0.014 15.2 4.8 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Cep57_MT_bd PF06657.13 EWC46588.1 - 0.1 13.1 5.8 0.69 10.4 0.5 2.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF641 PF04859.12 EWC46588.1 - 0.1 12.9 12.3 8.1 6.8 12.3 2.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) SNARE PF05739.19 EWC46588.1 - 0.12 12.4 0.1 0.29 11.2 0.1 1.7 1 0 0 1 1 1 0 SNARE domain Cob_adeno_trans PF01923.18 EWC46588.1 - 0.29 11.2 7.3 2.9 8.0 7.2 2.3 1 1 0 1 1 1 0 Cobalamin adenosyltransferase DUF1192 PF06698.11 EWC46588.1 - 0.92 9.6 5.4 0.79 9.8 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF1664 PF07889.12 EWC46588.1 - 9.9 6.2 7.7 4.9 7.2 3.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Tubulin PF00091.25 EWC46590.1 - 1.8e-56 191.4 0.0 2.9e-56 190.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EWC46590.1 - 2.1e-44 150.7 1.6 2.3e-44 150.6 0.2 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 EWC46590.1 - 0.044 13.0 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 Tubulin like HhH-GPD PF00730.25 EWC46591.1 - 5.5e-17 62.2 0.0 9.3e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EWC46591.1 - 0.00012 21.7 0.0 0.00034 20.3 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif Use1 PF09753.9 EWC46592.1 - 1.4e-08 34.8 2.4 2.3e-08 34.1 2.1 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 UPF0449 PF15136.6 EWC46592.1 - 0.018 15.5 0.6 0.018 15.5 0.6 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 MCM3AP_GANP PF16769.5 EWC46592.1 - 0.048 11.9 1.0 0.069 11.4 0.1 1.6 2 0 0 2 2 2 0 MCM3AP domain of GANP Synaptobrevin PF00957.21 EWC46592.1 - 0.91 9.4 7.4 2.3 8.1 0.5 3.0 3 1 0 3 3 3 0 Synaptobrevin Piwi PF02171.17 EWC46593.1 - 3.6e-72 243.2 0.0 2.7e-71 240.3 0.0 2.1 2 0 0 2 2 2 1 Piwi domain ArgoN PF16486.5 EWC46593.1 - 7.8e-16 58.9 0.0 1.7e-15 57.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 EWC46593.1 - 1e-12 48.2 0.2 5.4e-12 45.9 0.1 2.3 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoL1 PF08699.10 EWC46593.1 - 2.1e-11 43.3 0.3 7.7e-11 41.5 0.2 2.0 2 0 0 2 2 2 1 Argonaute linker 1 domain PAZ PF02170.22 EWC46593.1 - 2.3e-09 37.2 0.0 6.4e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EWC46593.1 - 0.00023 21.4 0.1 0.00058 20.1 0.1 1.7 1 0 0 1 1 1 1 Mid domain of argonaute G-alpha PF00503.20 EWC46595.1 - 5.2e-120 400.8 4.4 6.1e-120 400.6 4.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EWC46595.1 - 5.2e-15 55.3 2.5 2.2e-10 40.2 0.1 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 EWC46595.1 - 2.7e-05 23.9 0.0 0.00011 21.9 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger Gtr1_RagA PF04670.12 EWC46595.1 - 0.0025 17.2 4.1 0.2 11.0 0.0 3.1 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EWC46595.1 - 0.03 14.1 0.0 0.07 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EWC46595.1 - 0.036 14.3 1.6 2 8.6 0.1 2.8 1 1 2 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EWC46595.1 - 0.088 12.9 0.1 6.1 7.0 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase MCM PF00493.23 EWC46595.1 - 0.091 11.8 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain GTP_EFTU PF00009.27 EWC46595.1 - 0.12 12.0 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 EWC46595.1 - 0.13 11.5 0.1 0.4 10.0 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zip PF02535.22 EWC46596.1 - 2.4e-54 184.8 11.9 5.5e-54 183.6 11.9 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter DUF2157 PF09925.9 EWC46596.1 - 0.11 12.3 0.2 0.11 12.3 0.2 2.8 4 1 0 4 4 4 0 Predicted membrane protein (DUF2157) DLH PF01738.18 EWC46597.1 - 3.2e-24 85.7 0.0 4.5e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family RasGEF PF00617.19 EWC46598.1 - 6.2e-19 68.9 0.8 6.2e-19 68.9 0.8 1.9 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EWC46598.1 - 6.6e-05 23.1 0.1 0.00027 21.1 0.1 2.1 1 1 0 1 1 1 1 RasGEF N-terminal motif DUF202 PF02656.15 EWC46600.1 - 3.6e-21 75.4 1.0 3.6e-21 75.4 1.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF3784 PF12650.7 EWC46600.1 - 0.47 10.7 4.0 1.2 9.4 4.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) DUF1771 PF08590.10 EWC46601.1 - 1.4e-17 63.8 13.1 3.1e-17 62.7 13.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 EWC46601.1 - 2e-12 47.3 0.1 4.4e-12 46.2 0.1 1.6 1 0 0 1 1 1 1 Smr domain ProQ PF04352.13 EWC46601.1 - 0.016 15.1 8.1 0.21 11.5 0.0 3.0 3 0 0 3 3 3 0 ProQ/FINO family CYSTM PF12734.7 EWC46601.1 - 0.82 10.0 3.3 1.6 9.1 3.3 1.6 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance KTI12 PF08433.10 EWC46602.1 - 9.2e-94 313.9 0.0 1e-93 313.7 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EWC46602.1 - 4.9e-05 23.5 0.0 0.00012 22.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 EWC46602.1 - 0.021 14.7 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Glyco_hydro_18 PF00704.28 EWC46603.1 - 5e-24 85.6 0.0 7.2e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 RhoGAP PF00620.27 EWC46605.1 - 8.5e-32 110.1 0.0 1.9e-31 109.0 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain zf-Tim10_DDP PF02953.15 EWC46606.1 - 2.6e-19 68.6 3.9 3.1e-19 68.4 3.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 EWC46606.1 - 0.0012 18.5 1.4 0.0026 17.4 1.4 1.6 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Aminotran_5 PF00266.19 EWC46607.1 - 2e-95 319.9 0.0 2.6e-95 319.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EWC46607.1 - 1.4e-07 31.1 0.0 2.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EWC46607.1 - 9.6e-06 25.1 0.5 0.00011 21.6 0.1 2.4 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 EWC46607.1 - 0.026 13.2 0.0 0.038 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain BAR PF03114.18 EWC46608.1 - 4.9e-65 219.5 7.7 4.9e-65 219.5 7.7 1.5 2 0 0 2 2 2 1 BAR domain SH3_1 PF00018.28 EWC46608.1 - 9.5e-14 50.7 0.0 1.7e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC46608.1 - 8e-13 48.0 0.0 1.3e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EWC46608.1 - 9.7e-08 31.6 0.1 2.6e-07 30.2 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain Vps5 PF09325.10 EWC46608.1 - 0.00092 18.8 9.0 0.023 14.2 5.8 2.3 2 0 0 2 2 2 1 Vps5 C terminal like Dscam_C PF12355.8 EWC46608.1 - 0.074 14.0 1.3 0.13 13.2 1.3 1.4 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal PAS_6 PF08348.11 EWC46608.1 - 0.12 12.3 0.2 0.31 10.9 0.2 1.7 1 0 0 1 1 1 0 YheO-like PAS domain Laminin_II PF06009.12 EWC46608.1 - 0.13 12.2 4.0 0.94 9.5 2.5 2.4 2 0 0 2 2 2 0 Laminin Domain II Thiamine_BP PF01910.17 EWC46608.1 - 0.22 11.5 0.9 0.89 9.5 0.3 2.1 2 0 0 2 2 2 0 Thiamine-binding protein CorA PF01544.18 EWC46608.1 - 0.33 10.2 7.3 6.8 5.9 0.0 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein TMPIT PF07851.13 EWC46608.1 - 0.34 10.1 12.4 0.99 8.6 0.4 2.4 1 1 1 2 2 2 0 TMPIT-like protein APG6_N PF17675.1 EWC46608.1 - 0.73 10.4 10.8 8.3 7.0 6.2 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Fib_alpha PF08702.10 EWC46608.1 - 0.98 9.6 7.6 2.7 8.2 2.8 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3287 PF11690.8 EWC46608.1 - 1.7 8.4 7.5 0.4 10.4 3.7 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3287) DUF2203 PF09969.9 EWC46608.1 - 6.1 7.6 9.6 1.2 9.9 2.3 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) UEV PF05743.13 EWC46609.1 - 1.6e-37 128.0 0.0 2.8e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EWC46609.1 - 7.9e-29 99.4 0.5 1.6e-28 98.4 0.5 1.5 1 0 0 1 1 1 1 Vps23 core domain DUF1661 PF07877.11 EWC46609.1 - 0.016 14.9 0.2 0.033 13.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1661) Poty_PP PF08440.10 EWC46609.1 - 0.15 11.1 0.1 0.23 10.5 0.1 1.2 1 0 0 1 1 1 0 Potyviridae polyprotein GSHPx PF00255.19 EWC46610.1 - 5e-42 141.9 0.0 6.3e-42 141.5 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.10 EWC46610.1 - 0.00018 21.3 0.0 0.00029 20.6 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EWC46610.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family DUF3905 PF13045.6 EWC46610.1 - 0.073 13.1 0.0 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3905) GST_N_4 PF17172.4 EWC46612.1 - 3e-14 53.5 0.0 6.1e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 EWC46612.1 - 1.3e-13 51.3 0.0 2.3e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EWC46612.1 - 1.8e-11 43.6 0.0 3.7e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EWC46612.1 - 0.18 11.9 2.3 0.14 12.2 0.6 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Methyltransf_25 PF13649.6 EWC46613.1 - 3.6e-13 50.0 0.1 6.2e-13 49.3 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC46613.1 - 2e-10 40.7 0.0 2.7e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC46613.1 - 5.9e-09 36.5 0.1 1.4e-08 35.2 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EWC46613.1 - 1.4e-06 27.9 0.0 2.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 EWC46613.1 - 1.4e-06 28.0 0.0 2.2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EWC46613.1 - 2e-06 27.4 0.0 2.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 EWC46613.1 - 4.2e-06 27.4 0.2 1.3e-05 25.9 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC46613.1 - 2e-05 24.5 0.0 2.8e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC46613.1 - 8.3e-05 22.0 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 EWC46613.1 - 0.00018 20.7 0.0 0.00022 20.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltr_RsmB-F PF01189.17 EWC46613.1 - 0.0041 16.8 0.0 0.0063 16.2 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_32 PF13679.6 EWC46613.1 - 0.0088 16.0 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EWC46613.1 - 0.012 15.4 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 EWC46613.1 - 0.02 14.5 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_33 PF10017.9 EWC46613.1 - 0.026 13.7 0.0 0.032 13.4 0.0 1.1 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_18 PF12847.7 EWC46613.1 - 0.045 13.7 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 EWC46613.1 - 0.076 12.3 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_7 PF03492.15 EWC46613.1 - 0.15 11.2 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase CDC14 PF08045.11 EWC46614.1 - 2.7e-53 180.9 0.0 4.3e-53 180.3 0.0 1.3 1 1 0 1 1 1 1 Cell division control protein 14, SIN component Endonuc-dimeris PF09124.10 EWC46614.1 - 0.075 13.2 0.1 0.3 11.3 0.0 1.9 2 0 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation polyprenyl_synt PF00348.17 EWC46615.1 - 2.2e-65 220.3 0.0 2.8e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HAD PF12710.7 EWC46616.1 - 1.5e-24 87.5 0.0 2.1e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EWC46616.1 - 0.002 17.6 0.0 0.0079 15.6 0.0 1.8 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.26 EWC46616.1 - 0.0058 16.9 0.1 0.019 15.3 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EWC46616.1 - 0.043 13.3 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) PS_Dcarbxylase PF02666.15 EWC46617.1 - 1.3e-55 188.0 0.0 2e-55 187.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EWC46617.1 - 1.8e-40 137.4 0.1 3.2e-19 69.1 0.0 2.5 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 EWC46617.1 - 0.0011 18.5 0.0 0.073 12.6 0.0 2.4 2 0 0 2 2 2 1 CEP76 C2 domain EF-hand_1 PF00036.32 EWC46617.1 - 0.026 14.0 0.0 0.086 12.4 0.0 2.0 1 0 0 1 1 1 0 EF hand MIS13 PF08202.11 EWC46618.1 - 8.7e-43 146.7 5.3 8.7e-43 146.7 5.3 2.1 3 0 0 3 3 3 1 Mis12-Mtw1 protein family CAP_N PF01213.19 EWC46618.1 - 0.19 11.1 11.6 0.038 13.5 7.1 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EWC46618.1 - 0.27 11.3 6.6 0.61 10.1 6.6 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 EWC46618.1 - 0.39 10.8 15.2 0.29 11.2 4.0 3.0 2 1 0 3 3 3 0 Mitochondrial fission regulator GATA PF00320.27 EWC46619.1 - 3.8e-15 55.2 5.3 7.2e-15 54.3 5.3 1.5 1 0 0 1 1 1 1 GATA zinc finger zinc_ribbon_9 PF14369.6 EWC46619.1 - 0.5 10.7 1.6 1.1 9.6 1.6 1.5 1 0 0 1 1 1 0 zinc-ribbon GCS PF03074.16 EWC46620.1 - 3.4e-173 576.1 0.0 4.3e-173 575.8 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 EWC46620.1 - 0.0012 18.3 0.0 0.0093 15.3 0.0 2.0 2 0 0 2 2 2 1 Glutamate-cysteine ligase family 2(GCS2) Ank_5 PF13857.6 EWC46621.1 - 1.6e-15 57.0 0.5 5.6e-08 32.9 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EWC46621.1 - 1e-13 51.5 0.1 3.7e-10 40.1 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EWC46621.1 - 2.6e-13 50.4 0.3 3.4e-07 30.8 0.0 3.1 2 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EWC46621.1 - 5.4e-11 41.7 0.0 0.00018 21.7 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EWC46621.1 - 4.5e-10 39.5 0.1 0.0037 17.7 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat KilA-N PF04383.13 EWC46621.1 - 4.1e-05 23.4 0.0 0.00024 20.9 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain GDPD PF03009.17 EWC46622.1 - 2e-29 103.1 0.0 2.7e-29 102.7 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EWC46622.1 - 0.0061 17.0 0.3 0.015 15.8 0.3 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF3302 PF11742.8 EWC46622.1 - 0.022 14.9 0.8 0.046 13.8 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3302) Translin PF01997.16 EWC46623.1 - 7.9e-47 159.9 0.0 9.2e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Translin family PIG-F PF06699.11 EWC46624.1 - 5.1e-63 212.5 2.4 5.8e-63 212.3 2.4 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F DUF4345 PF14248.6 EWC46624.1 - 0.0018 18.2 0.4 0.0018 18.2 0.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4345) PRA1 PF03208.19 EWC46624.1 - 0.086 12.5 2.2 0.14 11.8 2.2 1.3 1 0 0 1 1 1 0 PRA1 family protein COPIIcoated_ERV PF07970.12 EWC46625.1 - 1.3e-40 139.6 0.0 1.8e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EWC46625.1 - 6.7e-25 87.3 0.0 1.1e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ubiquitin PF00240.23 EWC46626.1 - 1.8e-34 117.3 0.5 2.8e-34 116.7 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EWC46626.1 - 4.7e-16 58.4 0.6 6.6e-16 57.9 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-AN1 PF01428.16 EWC46626.1 - 5.9e-11 42.3 7.9 9.5e-11 41.7 7.9 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Ubiquitin_2 PF14560.6 EWC46626.1 - 3.1e-05 24.3 0.1 0.00012 22.4 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EWC46626.1 - 0.0057 16.6 0.0 0.0096 15.8 0.0 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EWC46626.1 - 0.0074 16.6 0.0 0.012 16.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EWC46626.1 - 0.01 15.9 0.0 0.03 14.4 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EWC46626.1 - 0.021 14.9 1.1 5.2 7.2 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 EWC46626.1 - 0.031 14.8 0.0 0.037 14.6 0.0 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Transp_Tc5_C PF04236.15 EWC46626.1 - 0.049 14.0 3.4 0.093 13.1 3.4 1.4 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain CsbD PF05532.12 EWC46627.1 - 4.7e-10 39.2 13.7 4.6e-09 36.0 1.7 3.1 3 0 0 3 3 3 2 CsbD-like STE2 PF02116.15 EWC46628.1 - 7.8e-61 205.8 12.7 9.3e-61 205.6 12.7 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR PsbL PF02419.17 EWC46628.1 - 0.092 12.7 1.9 0.25 11.3 1.9 1.8 1 0 0 1 1 1 0 PsbL protein NiFe_hyd_3_EhaA PF17367.2 EWC46628.1 - 0.24 11.5 5.8 0.18 12.0 2.1 2.5 2 1 0 2 2 2 0 NiFe-hydrogenase-type-3 Eha complex subunit A DUF3278 PF11683.8 EWC46628.1 - 1.2 9.2 7.8 1.3 9.1 5.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) DUF1325 PF07039.11 EWC46629.1 - 6.8e-30 103.9 0.0 3.5e-29 101.5 0.0 2.1 1 1 0 1 1 1 1 SGF29 tudor-like domain Tudor_3 PF18115.1 EWC46629.1 - 0.014 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain Myb_DNA-bind_4 PF13837.6 EWC46629.1 - 0.07 13.5 0.5 0.15 12.5 0.5 1.7 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain T3SS_needle_reg PF09025.10 EWC46629.1 - 0.24 11.4 1.3 12 5.9 0.1 2.2 1 1 1 2 2 2 0 YopR, type III needle-polymerisation regulator Myb_DNA-bind_5 PF13873.6 EWC46629.1 - 0.87 9.7 3.9 3 8.0 1.1 2.3 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Actin PF00022.19 EWC46630.1 - 3.3e-109 365.2 0.0 1.9e-108 362.7 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EWC46630.1 - 0.04 12.7 0.0 0.29 9.9 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein GTP_cyclohydro2 PF00925.20 EWC46631.1 - 2.4e-62 209.3 0.0 3.1e-62 209.0 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Clathrin PF00637.20 EWC46632.1 - 3.9e-16 59.2 3.4 2.3e-15 56.7 0.4 2.8 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.8 EWC46632.1 - 2.9e-11 43.4 0.4 2.9e-11 43.4 0.4 2.3 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EWC46632.1 - 6.7e-07 29.2 7.7 1.2e-06 28.5 7.7 1.4 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EWC46632.1 - 8.7e-06 25.5 8.8 1.6e-05 24.6 8.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC46632.1 - 0.0016 18.4 6.0 0.0028 17.6 6.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EWC46632.1 - 0.0018 18.6 7.6 0.0032 17.8 7.6 1.4 1 0 0 1 1 1 1 Ring finger domain Vps8 PF12816.7 EWC46632.1 - 0.0023 17.5 0.9 0.0065 16.0 0.2 1.9 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 TPR_11 PF13414.6 EWC46632.1 - 0.014 15.0 0.0 0.034 13.8 0.0 1.6 1 0 0 1 1 1 0 TPR repeat zf-rbx1 PF12678.7 EWC46632.1 - 0.018 15.3 5.9 0.037 14.3 5.9 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EWC46632.1 - 0.052 13.4 7.8 0.094 12.6 7.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 EWC46632.1 - 0.057 13.9 0.5 0.55 10.7 0.2 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 RPN7 PF10602.9 EWC46632.1 - 0.12 12.1 0.1 0.35 10.6 0.1 1.7 1 0 0 1 1 1 0 26S proteasome subunit RPN7 TPR_8 PF13181.6 EWC46632.1 - 0.29 11.4 1.4 1.2 9.5 0.1 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat PHD PF00628.29 EWC46632.1 - 1.9 8.5 5.0 3.7 7.5 5.0 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.5 EWC46632.1 - 3.1 7.6 5.0 7.1 6.5 5.0 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 EWC46632.1 - 4.8 7.3 8.5 10 6.2 8.5 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Pkinase PF00069.25 EWC46633.1 - 8.3e-61 205.6 0.1 3.2e-60 203.7 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46633.1 - 1.7e-35 122.6 0.0 2.8e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 EWC46633.1 - 1.5e-23 82.7 19.8 1.4e-13 50.7 6.2 2.4 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EWC46633.1 - 1.3e-21 76.2 29.2 8.4e-13 48.0 9.9 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 EWC46633.1 - 3.3e-14 53.3 1.6 1.3e-13 51.4 1.6 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 EWC46633.1 - 1.5e-05 25.2 0.0 2.6e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EWC46633.1 - 0.013 14.8 0.0 0.036 13.4 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Uds1 PF15456.6 EWC46633.1 - 0.97 9.6 8.5 0.39 10.9 0.9 2.4 2 0 0 2 2 2 0 Up-regulated During Septation C1_2 PF03107.16 EWC46633.1 - 1.5 9.2 24.0 1.5 9.2 9.6 2.5 2 0 0 2 2 2 0 C1 domain DUF892 PF05974.12 EWC46633.1 - 2.2 8.3 6.9 0.15 12.1 1.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF892) IDO PF01231.18 EWC46634.1 - 1.4e-162 541.5 0.0 1.6e-162 541.3 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 EWC46634.1 - 0.19 10.4 0.0 1.6 7.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1864) Pkinase PF00069.25 EWC46635.1 - 1.3e-52 178.8 0.0 2.1e-52 178.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46635.1 - 5.8e-19 68.4 0.0 1.6e-18 66.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EWC46635.1 - 0.00055 19.9 0.1 0.0031 17.5 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EWC46635.1 - 0.21 11.2 0.1 0.39 10.3 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA4 PF13093.6 EWC46636.1 - 1e-39 136.5 0.0 1.2e-39 136.3 0.0 1.0 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 MCM PF00493.23 EWC46637.1 - 4.1e-100 333.5 0.0 4.1e-100 333.5 0.0 1.5 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EWC46637.1 - 3.4e-39 133.6 0.0 6.2e-39 132.7 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EWC46637.1 - 2.5e-26 91.9 0.1 1e-25 89.9 0.0 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM2_N PF12619.8 EWC46637.1 - 4.2e-22 79.1 29.3 4.2e-22 79.1 29.3 2.1 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 EWC46637.1 - 7.2e-14 52.2 0.1 1.7e-13 51.0 0.1 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EWC46637.1 - 1.5e-08 34.3 0.0 1.4e-06 27.9 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EWC46637.1 - 1e-06 28.8 0.0 2.2e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EWC46637.1 - 0.00021 21.2 0.0 0.0015 18.4 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EWC46637.1 - 0.0032 17.2 0.0 0.016 14.9 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 EWC46637.1 - 0.066 12.9 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain ATG16 PF08614.11 EWC46638.1 - 0.00089 19.5 55.0 0.0087 16.3 9.5 5.2 1 1 4 5 5 4 3 Autophagy protein 16 (ATG16) GAS PF13851.6 EWC46638.1 - 0.0091 15.4 4.7 0.0091 15.4 4.7 4.7 2 1 3 5 5 5 2 Growth-arrest specific micro-tubule binding Cnn_1N PF07989.11 EWC46638.1 - 0.015 15.4 21.6 0.71 10.1 0.4 5.5 3 2 3 6 6 5 0 Centrosomin N-terminal motif 1 Golgin_A5 PF09787.9 EWC46638.1 - 0.079 12.4 27.8 0.25 10.7 14.0 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 KASH_CCD PF14662.6 EWC46638.1 - 0.093 12.5 30.6 0.035 14.0 3.1 3.9 1 1 3 4 4 4 0 Coiled-coil region of CCDC155 or KASH DUF812 PF05667.11 EWC46638.1 - 0.11 11.3 25.7 0.034 13.1 13.8 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF812) FPP PF05911.11 EWC46638.1 - 0.27 9.4 26.2 0.12 10.6 17.1 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Filament PF00038.21 EWC46638.1 - 0.34 10.5 27.7 0.19 11.2 9.1 3.1 1 1 2 3 3 3 0 Intermediate filament protein PI3K_P85_iSH2 PF16454.5 EWC46638.1 - 0.42 10.2 15.0 5.1 6.7 7.2 3.3 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4665 PF15679.5 EWC46638.1 - 0.81 10.3 5.3 3.2 8.4 0.3 3.7 2 1 0 3 3 3 0 Domain of unknown function (DUF4665) ADIP PF11559.8 EWC46638.1 - 0.91 9.6 28.9 0.088 12.9 4.1 4.0 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Cep57_MT_bd PF06657.13 EWC46638.1 - 0.97 9.9 18.1 0.072 13.5 2.0 4.2 2 1 3 5 5 5 0 Centrosome microtubule-binding domain of Cep57 UPF0242 PF06785.11 EWC46638.1 - 1.7 8.7 27.4 20 5.2 3.4 3.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Syntaxin-6_N PF09177.11 EWC46638.1 - 2.2 8.9 22.3 0.55 10.8 0.5 4.3 2 1 2 4 4 3 0 Syntaxin 6, N-terminal HOOK PF05622.12 EWC46638.1 - 2.3 6.3 31.3 2.4 6.2 0.8 2.7 1 1 0 2 2 2 0 HOOK protein CENP-F_leu_zip PF10473.9 EWC46638.1 - 4.3 7.3 39.2 0.15 12.1 9.3 3.6 2 1 2 4 4 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.11 EWC46638.1 - 4.4 6.1 38.0 0.41 9.4 30.6 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 EWC46638.1 - 6.6 5.5 38.5 0.4 9.5 11.3 3.5 2 1 2 4 4 4 0 Spc7 kinetochore protein YabA PF06156.13 EWC46638.1 - 7.2 7.3 22.3 10 6.8 0.2 5.0 1 1 3 4 4 4 0 Initiation control protein YabA APG6_N PF17675.1 EWC46638.1 - 8.1 7.0 45.0 1.5 9.4 11.5 4.0 2 1 2 4 4 3 0 Apg6 coiled-coil region Kinesin PF00225.23 EWC46639.1 - 1.3e-88 297.2 0.0 1.3e-88 297.2 0.0 2.3 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EWC46639.1 - 4.7e-20 72.0 0.0 1.8e-15 57.2 0.0 3.2 2 1 1 3 3 3 2 Microtubule binding Filament PF00038.21 EWC46639.1 - 0.00013 21.7 103.8 0.00048 19.8 9.2 8.4 5 4 2 7 7 7 4 Intermediate filament protein APG17 PF04108.12 EWC46639.1 - 0.013 14.6 0.5 0.013 14.6 0.5 7.1 5 2 1 6 6 6 0 Autophagy protein Apg17 Linker_histone PF00538.19 EWC46640.1 - 2.7e-29 101.3 1.1 3e-29 101.2 0.1 1.6 2 0 0 2 2 2 1 linker histone H1 and H5 family ThrE PF06738.12 EWC46641.1 - 1.6e-64 217.5 22.5 7.9e-64 215.3 4.0 2.4 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EWC46641.1 - 1.4e-11 44.7 8.5 1.4e-11 44.7 8.5 3.2 3 0 0 3 3 3 1 Threonine/Serine exporter, ThrE SIKE PF05769.11 EWC46643.1 - 1.5e-07 31.5 9.5 1.9e-07 31.2 9.5 1.1 1 0 0 1 1 1 1 SIKE family YadA_stalk PF05662.14 EWC46643.1 - 0.012 16.0 1.2 3.2 8.2 0.1 2.7 2 0 0 2 2 2 0 Coiled stalk of trimeric autotransporter adhesin IES5 PF17335.2 EWC46643.1 - 0.046 14.0 1.7 0.1 12.9 1.2 1.8 1 1 1 2 2 2 0 Ino80 complex subunit 5 ZapB PF06005.12 EWC46643.1 - 0.26 11.8 13.6 1 9.8 1.2 3.9 3 1 1 4 4 4 0 Cell division protein ZapB PRKG1_interact PF15898.5 EWC46643.1 - 0.36 11.7 9.4 0.15 13.0 1.8 2.6 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain MCC-bdg_PDZ PF10506.9 EWC46643.1 - 2.5 8.2 9.2 17 5.5 0.1 3.8 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome AT_hook PF02178.19 EWC46644.1 - 0.00027 20.5 24.6 0.33 11.0 5.0 4.9 3 0 0 3 3 3 3 AT hook motif CSN8_PSD8_EIF3K PF10075.9 EWC46645.1 - 4.5e-20 72.1 0.0 7.2e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EWC46645.1 - 0.0051 16.2 0.0 0.007 15.8 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP family Kelch_6 PF13964.6 EWC46646.1 - 0.017 15.4 0.1 1.1 9.6 0.0 3.0 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 EWC46646.1 - 0.019 15.9 7.3 1.7 9.7 0.4 5.0 6 0 0 6 6 6 0 WD domain, G-beta repeat Fungal_trans_2 PF11951.8 EWC46647.1 - 4.4e-57 193.7 0.0 5.6e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC46647.1 - 2.5e-09 37.1 9.7 4.1e-09 36.4 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.20 EWC46648.1 - 3.3e-158 526.9 0.0 4e-158 526.6 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EWC46648.1 - 3.8e-09 36.7 0.2 1.1e-08 35.2 0.1 1.9 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EWC46648.1 - 2.1e-05 24.9 0.0 5.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain ABC_tran PF00005.27 EWC46649.1 - 1.5e-48 164.8 0.9 9.6e-26 90.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 EWC46649.1 - 1.4e-42 145.5 33.4 1.8e-23 83.1 15.7 2.3 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.6 EWC46649.1 - 1.5e-13 51.2 1.5 0.022 14.6 0.1 4.5 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EWC46649.1 - 1.2e-12 47.7 0.4 6.3e-05 22.5 0.0 3.9 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EWC46649.1 - 5.3e-09 35.7 3.6 0.0015 18.2 0.9 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EWC46649.1 - 1.2e-08 35.5 0.4 0.0061 17.0 0.0 3.0 2 1 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EWC46649.1 - 1.9e-08 34.4 3.4 0.00051 20.0 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EWC46649.1 - 2.3e-07 31.5 0.7 0.011 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EWC46649.1 - 9.8e-06 25.9 0.5 0.048 13.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 EWC46649.1 - 1.9e-05 25.2 0.1 0.08 13.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EWC46649.1 - 3.9e-05 24.0 0.2 0.13 12.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_5 PF07728.14 EWC46649.1 - 6.9e-05 22.9 0.6 0.65 10.0 0.1 3.2 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EWC46649.1 - 9.5e-05 22.7 0.5 0.78 10.0 0.6 2.6 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EWC46649.1 - 0.00013 21.8 0.5 0.14 11.9 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EWC46649.1 - 0.00028 20.5 0.4 0.91 9.1 0.1 2.8 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EWC46649.1 - 0.00044 20.2 0.1 0.56 10.1 0.0 2.6 2 0 0 2 2 2 2 NACHT domain MMR_HSR1 PF01926.23 EWC46649.1 - 0.00047 20.2 2.7 0.69 10.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EWC46649.1 - 0.0007 19.5 0.4 2.5 7.8 0.0 3.4 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein AAA PF00004.29 EWC46649.1 - 0.001 19.5 0.1 2.5 8.5 0.1 3.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EWC46649.1 - 0.0011 19.1 0.1 0.18 11.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EWC46649.1 - 0.0012 18.6 2.8 0.48 10.1 0.2 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_7 PF12775.7 EWC46649.1 - 0.0012 18.4 1.4 0.31 10.5 0.3 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region KAP_NTPase PF07693.14 EWC46649.1 - 0.003 16.8 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 1 KAP family P-loop domain ATPase_2 PF01637.18 EWC46649.1 - 0.0035 17.3 0.1 0.1 12.5 0.0 2.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea cobW PF02492.19 EWC46649.1 - 0.0091 15.6 1.5 2.1 7.9 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.6 EWC46649.1 - 0.01 16.0 0.3 6.6 7.0 0.0 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.18 EWC46649.1 - 0.011 15.1 0.9 2.4 7.5 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 EWC46649.1 - 0.013 14.6 1.7 1.5 7.8 0.0 2.8 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_24 PF13479.6 EWC46649.1 - 0.013 15.2 0.2 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EWC46649.1 - 0.015 15.5 0.4 5 7.4 0.2 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EWC46649.1 - 0.021 14.6 0.3 3.7 7.2 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_17 PF13207.6 EWC46649.1 - 0.022 15.2 0.1 11 6.5 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EWC46649.1 - 0.022 15.1 1.8 1.1 9.6 0.5 2.8 2 1 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EWC46649.1 - 0.023 14.4 1.9 0.15 11.8 0.0 2.5 3 0 0 3 3 2 0 Cytidylate kinase DUF815 PF05673.13 EWC46649.1 - 0.023 13.9 0.5 1.8 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PRK PF00485.18 EWC46649.1 - 0.029 14.1 1.1 6.4 6.5 0.4 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Dynamin_N PF00350.23 EWC46649.1 - 0.03 14.4 3.5 4.4 7.3 0.1 2.6 2 0 0 2 2 2 0 Dynamin family ATP-synt_ab PF00006.25 EWC46649.1 - 0.046 13.4 0.0 0.71 9.5 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.12 EWC46649.1 - 0.081 12.2 1.3 3.8 6.7 0.2 2.4 2 0 0 2 2 2 0 Zeta toxin PduV-EutP PF10662.9 EWC46649.1 - 0.16 11.7 0.2 12 5.7 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DnaB_C PF03796.15 EWC46649.1 - 0.16 11.3 0.4 5.5 6.2 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_27 PF13514.6 EWC46649.1 - 0.2 11.2 0.3 4.8 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 EWC46649.1 - 0.51 9.6 1.9 8 5.7 0.4 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Sec23_trunk PF04811.15 EWC46650.1 - 1.1e-49 169.2 0.0 6.4e-49 166.7 0.0 2.0 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EWC46650.1 - 1.6e-27 95.3 0.1 2.9e-27 94.5 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EWC46650.1 - 5.4e-19 68.7 0.1 9.1e-19 68.0 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EWC46650.1 - 1.3e-13 50.7 4.5 2.6e-13 49.8 4.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EWC46650.1 - 4e-07 29.9 0.0 1.1e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat DUF1678 PF07913.11 EWC46650.1 - 0.041 13.7 0.1 0.34 10.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1678) Histidinol_dh PF00815.20 EWC46650.1 - 0.12 11.4 0.3 0.42 9.6 0.0 1.8 2 0 0 2 2 2 0 Histidinol dehydrogenase Vg_Tdu PF07545.14 EWC46650.1 - 0.16 11.7 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Vestigial/Tondu family F-box-like PF12937.7 EWC46651.1 - 1.1e-09 38.0 1.3 2.5e-09 36.9 1.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC46651.1 - 0.015 15.2 0.4 0.085 12.8 0.2 2.4 2 0 0 2 2 2 0 F-box domain DUF3646 PF12362.8 EWC46651.1 - 0.06 13.7 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal SDA1 PF05285.12 EWC46651.1 - 0.61 9.5 5.1 0.95 8.8 5.1 1.2 1 0 0 1 1 1 0 SDA1 F-box PF00646.33 EWC46652.1 - 0.00049 19.9 1.0 0.0012 18.7 0.5 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EWC46652.1 - 0.00071 19.4 0.7 0.0021 17.9 0.7 1.9 1 0 0 1 1 1 1 F-box-like BTB PF00651.31 EWC46655.1 - 1.1e-11 44.9 0.0 2e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DZR PF12773.7 EWC46655.1 - 0.046 13.8 0.7 0.083 12.9 0.7 1.3 1 0 0 1 1 1 0 Double zinc ribbon Tmemb_55A PF09788.9 EWC46655.1 - 0.078 12.0 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 55A Phage_int_SAM_1 PF02899.17 EWC46655.1 - 0.15 12.4 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain BTB PF00651.31 EWC46656.1 - 6.8e-13 48.8 0.0 1.1e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.8 EWC46656.1 - 0.0053 16.9 0.0 0.021 15.0 0.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF3342) ArgoL1 PF08699.10 EWC46656.1 - 0.044 13.5 0.0 1.5 8.5 0.0 2.4 1 1 0 1 1 1 0 Argonaute linker 1 domain DUF4470 PF14737.6 EWC46657.1 - 3.9e-21 75.1 0.0 8.5e-21 74.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 EWC46657.1 - 7.5e-10 38.7 14.0 1.7e-09 37.6 14.0 1.7 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EWC46657.1 - 0.087 13.1 10.7 0.38 11.1 10.7 2.1 1 1 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-HIT PF04438.16 EWC46657.1 - 4.6 7.2 9.3 12 5.9 9.3 1.7 1 0 0 1 1 1 0 HIT zinc finger BTB PF00651.31 EWC46658.1 - 1.5e-16 60.6 0.0 2.3e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3703 PF12487.8 EWC46658.1 - 0.018 14.8 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3703) F-box_4 PF15966.5 EWC46659.1 - 0.02 14.8 0.0 0.076 12.9 0.0 2.0 1 0 0 1 1 1 0 F-box LRR_8 PF13855.6 EWC46659.1 - 0.051 13.3 0.3 9.5 6.1 0.0 3.1 3 0 0 3 3 3 0 Leucine rich repeat F-box-like PF12937.7 EWC46659.1 - 0.2 11.6 1.6 0.59 10.1 0.0 2.6 3 0 0 3 3 3 0 F-box-like GFA PF04828.14 EWC46660.1 - 4.1e-15 55.9 0.8 1.6e-05 25.1 0.0 3.6 2 1 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DUF3712 PF12505.8 EWC46661.1 - 0.15 12.3 0.5 2.9 8.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3712) GST_N_4 PF17172.4 EWC46662.1 - 4.3e-23 81.9 0.0 6.6e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 EWC46662.1 - 2.6e-10 40.7 0.0 3.7e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EWC46662.1 - 1.1e-05 25.1 0.0 9.5e-05 22.1 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EWC46662.1 - 0.00025 21.4 0.0 0.00051 20.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EWC46662.1 - 0.0019 18.2 0.0 0.0056 16.7 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EWC46662.1 - 0.002 18.5 0.0 0.0032 17.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DDHD PF02862.17 EWC46664.1 - 0.24 11.5 8.9 2 8.5 10.4 1.9 2 0 0 2 2 2 0 DDHD domain SOG2 PF10428.9 EWC46664.1 - 0.96 8.6 31.6 0.19 10.9 20.8 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein Dicty_REP PF05086.12 EWC46664.1 - 5.5 4.8 24.7 7.8 4.3 24.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Fungal_lectin_2 PF18647.1 EWC46665.1 - 9.8e-10 38.8 0.0 2.2e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 Alpha-galactosyl-binding fungal lectin Treslin_N PF15292.6 EWC46668.1 - 0.12 10.7 0.2 0.18 10.1 0.2 1.2 1 0 0 1 1 1 0 Treslin N-terminus BTB PF00651.31 EWC46671.1 - 1.9e-08 34.5 0.0 3.7e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain p450 PF00067.22 EWC46673.1 - 2e-57 195.0 0.0 2.6e-57 194.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aldedh PF00171.22 EWC46678.1 - 5.3e-140 467.0 0.0 6.4e-140 466.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family CBM_1 PF00734.18 EWC46681.1 - 1.9e-12 46.9 13.9 1.9e-12 46.9 13.9 2.2 2 0 0 2 2 2 1 Fungal cellulose binding domain Esterase PF00756.20 EWC46681.1 - 8.5e-07 28.9 0.4 4.2e-06 26.6 0.4 1.9 1 1 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 EWC46681.1 - 0.0014 18.5 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DAAD PF18752.1 EWC46681.1 - 0.0053 16.7 0.0 0.008 16.1 0.0 1.2 1 0 0 1 1 1 1 Dictyosteliid AID/APOBEC-like Deaminase Abhydrolase_1 PF00561.20 EWC46681.1 - 0.012 15.3 0.2 0.047 13.3 0.1 1.9 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF3439 PF11921.8 EWC46681.1 - 0.018 15.0 16.6 0.041 13.8 16.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Esterase_phd PF10503.9 EWC46681.1 - 0.043 13.3 0.2 0.23 10.9 0.1 2.0 2 0 0 2 2 2 0 Esterase PHB depolymerase SSP160 PF06933.11 EWC46681.1 - 0.29 9.3 22.3 0.42 8.8 22.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 EWC46681.1 - 0.65 7.9 6.9 0.82 7.6 6.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Zn_clus PF00172.18 EWC46682.1 - 0.25 11.5 12.5 0.2 11.8 10.8 1.8 2 1 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_7 PF00840.20 EWC46684.1 - 2.9e-141 471.2 1.4 3.4e-141 470.9 1.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Lactamase_B_6 PF16661.5 EWC46685.1 - 6.1e-65 218.3 0.0 1.1e-64 217.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EWC46685.1 - 4.2e-36 124.7 4.0 1.3e-35 123.1 0.0 2.8 3 1 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EWC46685.1 - 3.7e-14 52.9 0.0 1.2e-13 51.3 0.0 1.9 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 EWC46685.1 - 2.8e-11 43.2 0.0 5.1e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EWC46685.1 - 5e-06 26.7 0.1 1.5e-05 25.1 0.1 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EWC46685.1 - 7e-05 22.4 0.0 0.0003 20.4 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain PBP PF01161.20 EWC46687.1 - 2.9e-16 60.0 0.0 4.8e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein YhhN PF07947.14 EWC46688.1 - 3.5e-31 108.2 6.3 4.3e-15 55.8 0.1 2.3 2 0 0 2 2 2 2 YhhN family HRI1 PF16815.5 EWC46693.1 - 1.3e-36 126.5 0.0 1.5e-36 126.3 0.0 1.0 1 0 0 1 1 1 1 Protein HRI1 DUF2219 PF09982.9 EWC46695.1 - 0.077 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2219) DUF1002 PF06207.11 EWC46696.1 - 7.2 6.1 11.2 12 5.3 11.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) TMEM52 PF14979.6 EWC46699.1 - 0.0028 17.6 3.2 0.0067 16.4 3.2 1.6 1 0 0 1 1 1 1 Transmembrane 52 Rhabdo_glycop PF00974.18 EWC46699.1 - 0.006 15.1 1.0 0.0085 14.6 1.0 1.1 1 0 0 1 1 1 1 Rhabdovirus spike glycoprotein Orthoreo_P10 PF07204.11 EWC46699.1 - 0.024 14.6 0.2 0.044 13.7 0.2 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.6 EWC46699.1 - 0.064 14.2 0.0 0.11 13.4 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 EWC46699.1 - 1.8 8.4 8.7 2.9 7.7 8.7 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 ApoO PF09769.9 EWC46701.1 - 1.5e-34 118.7 0.6 1.6e-33 115.5 0.0 2.0 2 0 0 2 2 2 1 Apolipoprotein O RNA_pol_Rpb2_6 PF00562.28 EWC46702.1 - 4.8e-108 361.7 0.1 1.8e-107 359.8 0.1 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EWC46702.1 - 2e-35 122.2 0.0 3.2e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EWC46702.1 - 2e-28 98.3 0.2 5.4e-28 97.0 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 EWC46702.1 - 2.9e-25 88.0 0.0 5.8e-25 87.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EWC46702.1 - 2e-21 76.5 0.1 4e-21 75.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EWC46702.1 - 3.8e-14 52.9 0.0 5.9e-13 49.0 0.0 2.4 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 zf-MYND PF01753.18 EWC46704.1 - 5.4e-08 32.8 10.7 8.7e-08 32.1 10.7 1.3 1 0 0 1 1 1 1 MYND finger Lar_restr_allev PF14354.6 EWC46704.1 - 0.76 10.2 6.5 12 6.4 5.8 2.4 2 0 0 2 2 2 0 Restriction alleviation protein Lar Pil1 PF13805.6 EWC46705.1 - 1e-98 330.1 3.6 1.3e-98 329.7 3.6 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.11 EWC46705.1 - 0.011 15.1 1.4 0.016 14.6 1.4 1.2 1 0 0 1 1 1 0 FAM92 protein CsgA PF17334.2 EWC46705.1 - 0.098 13.4 0.0 0.26 12.1 0.0 1.7 1 0 0 1 1 1 0 Minor curli fiber component A SWI-SNF_Ssr4 PF08549.10 EWC46706.1 - 4.2e-35 121.6 13.1 9.8e-35 120.4 13.1 1.6 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) KAR9 PF08580.10 EWC46707.1 - 3e-128 429.3 0.3 5.2e-128 428.5 0.3 1.4 1 0 0 1 1 1 1 Yeast cortical protein KAR9 Spectrin PF00435.21 EWC46707.1 - 3.5e-06 27.5 5.0 0.012 16.1 0.0 3.4 3 0 0 3 3 3 2 Spectrin repeat PLU-1 PF08429.11 EWC46707.1 - 0.031 13.5 3.1 0.17 11.0 0.0 2.7 1 1 2 3 3 3 0 PLU-1-like protein Prefoldin_2 PF01920.20 EWC46707.1 - 0.1 12.6 2.5 2.6 8.1 0.2 3.3 4 0 0 4 4 4 0 Prefoldin subunit DUF4795 PF16043.5 EWC46707.1 - 0.13 11.8 13.1 0.9 9.1 7.1 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) FH2 PF02181.23 EWC46707.1 - 0.34 10.0 3.2 11 5.1 0.6 3.1 3 0 0 3 3 3 0 Formin Homology 2 Domain Com_YlbF PF06133.11 EWC46707.1 - 2.7 8.6 6.0 2.2 8.9 0.2 3.4 4 1 0 4 4 4 0 Control of competence regulator ComK, YlbF/YmcA ThrE PF06738.12 EWC46708.1 - 1.2e-53 182.0 15.9 7.5e-52 176.1 4.7 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EWC46708.1 - 0.00019 21.6 27.7 0.00053 20.1 8.4 3.2 3 1 0 3 3 3 2 Threonine/Serine exporter, ThrE Neurensin PF14927.6 EWC46708.1 - 0.033 13.9 0.7 0.11 12.2 0.7 1.8 1 0 0 1 1 1 0 Neurensin UDG PF03167.19 EWC46709.1 - 5.5e-19 68.7 0.1 9.2e-19 67.9 0.1 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Thioredoxin PF00085.20 EWC46710.1 - 6.9e-62 205.9 4.4 3.1e-31 107.4 0.2 3.8 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EWC46710.1 - 2.5e-46 157.9 0.0 1.3e-34 119.7 0.0 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Calsequestrin PF01216.17 EWC46710.1 - 8.5e-14 51.4 0.2 1.8e-13 50.3 0.2 1.6 1 1 0 1 1 1 1 Calsequestrin OST3_OST6 PF04756.13 EWC46710.1 - 3e-11 43.2 1.5 0.00054 19.4 0.0 3.2 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EWC46710.1 - 2.2e-10 40.6 1.6 7.9e-05 22.8 0.0 3.1 3 1 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EWC46710.1 - 7.8e-09 36.0 1.5 0.00036 21.0 0.1 3.3 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EWC46710.1 - 1.1e-08 35.2 0.1 0.0083 16.4 0.0 4.1 4 1 0 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EWC46710.1 - 5.8e-07 29.5 0.7 0.0026 17.7 0.1 2.9 2 1 0 2 2 2 2 AhpC/TSA family ERp29_N PF07912.13 EWC46710.1 - 1.1e-06 28.8 0.3 0.0085 16.2 0.0 3.5 4 1 0 4 4 4 2 ERp29, N-terminal domain Redoxin PF08534.10 EWC46710.1 - 0.00025 20.8 2.6 0.72 9.5 1.3 3.4 2 1 0 2 2 2 2 Redoxin Thioredoxin_4 PF13462.6 EWC46710.1 - 0.031 14.4 3.1 20 5.3 0.1 4.1 3 2 1 4 4 4 0 Thioredoxin GST_C_6 PF17171.4 EWC46710.1 - 0.068 13.0 0.0 0.59 10.0 0.0 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Hydantoinase_B PF02538.14 EWC46711.1 - 6.7e-220 730.9 0.4 9.2e-220 730.4 0.4 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EWC46711.1 - 3.3e-102 341.7 0.4 6.2e-102 340.8 0.4 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EWC46711.1 - 9.5e-63 211.1 1.5 3.7e-61 205.9 0.0 2.9 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region GRASP55_65 PF04495.14 EWC46712.1 - 1.1e-46 158.6 0.0 1.3e-44 151.8 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PCI PF01399.27 EWC46713.1 - 3.6e-08 33.9 0.0 8.2e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain Gcn1_N PF12074.8 EWC46714.1 - 1.3e-93 314.1 0.0 8.1e-93 311.5 0.0 2.5 2 0 0 2 2 2 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 EWC46714.1 - 4.8e-33 110.4 30.1 0.16 12.3 0.0 22.3 26 0 0 26 26 23 8 HEAT repeat HEAT_EZ PF13513.6 EWC46714.1 - 1.7e-26 92.3 38.1 3.3e-05 24.3 0.0 19.8 20 2 4 24 24 23 5 HEAT-like repeat HEAT_2 PF13646.6 EWC46714.1 - 4.4e-26 91.1 38.0 6.2e-05 23.3 0.0 17.0 10 4 7 19 19 19 8 HEAT repeats Cnd1 PF12717.7 EWC46714.1 - 3.5e-14 53.2 1.0 2.6 8.0 0.0 11.0 9 3 1 11 11 11 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EWC46714.1 - 2.5e-13 50.4 0.0 2.4 8.8 0.1 9.1 9 1 1 10 10 8 3 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EWC46714.1 - 1.1e-08 35.0 0.0 0.19 11.2 0.0 6.6 5 1 1 7 7 7 2 CLASP N terminal ParcG PF10274.9 EWC46714.1 - 4.7e-07 30.1 0.9 0.11 12.6 0.0 5.8 6 0 0 6 6 6 2 Parkin co-regulated protein UME PF08064.13 EWC46714.1 - 4.7e-06 26.4 0.0 6.4 6.8 0.0 7.6 6 2 1 7 7 6 1 UME (NUC010) domain Adaptin_N PF01602.20 EWC46714.1 - 1.5e-05 23.7 14.8 0.82 8.2 0.0 9.0 8 3 0 8 8 8 2 Adaptin N terminal region MMS19_N PF14500.6 EWC46714.1 - 0.00021 21.0 18.3 0.75 9.3 0.0 8.6 9 1 0 9 9 8 2 Dos2-interacting transcription regulator of RNA-Pol-II DUF937 PF06078.11 EWC46714.1 - 0.00067 20.3 1.7 17 6.0 0.1 6.3 6 0 0 6 6 6 0 Bacterial protein of unknown function (DUF937) TIP120 PF08623.10 EWC46714.1 - 0.001 18.9 1.9 0.5 10.1 0.0 5.6 6 1 1 7 7 7 1 TATA-binding protein interacting (TIP20) Ecm29 PF13001.7 EWC46714.1 - 0.0012 17.6 0.3 0.028 13.1 0.0 3.6 3 0 0 3 3 3 1 Proteasome stabiliser FANCI_S2 PF14676.6 EWC46714.1 - 0.0044 17.3 0.0 5 7.4 0.0 3.6 2 0 0 2 2 2 1 FANCI solenoid 2 Tti2 PF10521.9 EWC46714.1 - 0.0084 15.7 0.5 11 5.5 0.0 4.1 4 0 0 4 4 4 0 Tti2 family RasGEF_N_2 PF14663.6 EWC46714.1 - 0.01 16.2 0.1 1.7 9.1 0.0 4.7 6 0 0 6 6 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RIX1 PF08167.12 EWC46714.1 - 0.015 15.1 0.2 0.39 10.4 0.1 3.7 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Cnd3 PF12719.7 EWC46714.1 - 0.19 10.9 7.0 0.94 8.6 0.0 4.5 4 0 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain Cohesin_HEAT PF12765.7 EWC46714.1 - 0.44 10.9 10.2 1e+02 3.3 0.0 6.6 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion MMS19_C PF12460.8 EWC46714.1 - 3.7 6.6 27.1 0.28 10.2 0.1 8.0 8 2 1 9 9 9 0 RNAPII transcription regulator C-terminal BRCT_2 PF16589.5 EWC46715.1 - 1.1e-06 28.9 0.0 1.3e-05 25.5 0.0 2.5 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EWC46715.1 - 2.3e-05 24.2 0.1 0.00038 20.4 0.0 2.4 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 EWC46715.1 - 0.00016 22.0 0.0 0.00056 20.2 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EWC46715.1 - 0.016 15.5 0.1 0.16 12.3 0.0 2.2 1 1 1 2 2 2 0 DNA ligase 3 BRCT domain PAP1 PF08601.10 EWC46715.1 - 0.53 10.0 6.0 0.68 9.6 6.0 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 KilA-N PF04383.13 EWC46716.1 - 0.00076 19.3 0.0 0.01 15.7 0.0 2.3 1 1 0 1 1 1 1 KilA-N domain PC4 PF02229.16 EWC46717.1 - 5.5e-23 80.4 0.1 5.5e-23 80.4 0.1 2.1 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) XRN_M PF17846.1 EWC46717.1 - 0.16 10.9 7.1 0.24 10.3 7.1 1.2 1 0 0 1 1 1 0 Xrn1 helical domain MIT PF04212.18 EWC46718.1 - 1.3e-12 47.6 0.4 3.5e-12 46.2 0.4 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DDHD PF02862.17 EWC46719.1 - 1.3e-54 185.7 0.0 2.5e-54 184.8 0.0 1.5 1 0 0 1 1 1 1 DDHD domain DUF601 PF04642.12 EWC46719.1 - 3.6 7.0 11.2 0.29 10.6 4.9 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF601 Mito_carr PF00153.27 EWC46723.1 - 5.9e-63 208.8 2.2 4.1e-21 74.7 0.1 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 EWC46723.1 - 0.0087 15.2 0.3 0.045 12.9 0.1 2.1 2 0 0 2 2 2 1 Gammaproteobacterial serine protease YtxH PF12732.7 EWC46723.1 - 0.044 14.3 0.1 0.079 13.5 0.1 1.3 1 0 0 1 1 1 0 YtxH-like protein GST_N_3 PF13417.6 EWC46724.1 - 3.4e-10 40.2 0.0 7.4e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EWC46724.1 - 6.8e-05 23.1 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tyrosinase PF00264.20 EWC46726.1 - 5.7e-37 128.1 0.7 9.7e-37 127.4 0.7 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EWC46726.1 - 3.2e-32 111.7 0.0 6.8e-32 110.7 0.0 1.6 1 0 0 1 1 1 1 Tyosinase C-terminal domain Sugar_tr PF00083.24 EWC46727.1 - 3e-51 174.7 17.5 5.3e-49 167.3 17.5 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1479 PF07350.12 EWC46728.1 - 1.1e-114 383.4 0.0 1.3e-114 383.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 EWC46728.1 - 0.0097 16.2 0.1 0.21 11.8 0.2 2.7 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1776 PF08643.10 EWC46728.1 - 0.24 10.7 0.0 0.41 10.0 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Actin PF00022.19 EWC46731.1 - 2.4e-128 428.3 0.0 2.7e-128 428.1 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EWC46731.1 - 0.0043 15.9 0.0 1.7 7.3 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein MBOAT PF03062.19 EWC46732.1 - 1.1e-44 153.3 14.3 2.4e-44 152.1 14.3 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DEAD PF00270.29 EWC46733.1 - 6.8e-24 84.6 0.1 1.7e-23 83.3 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RQC PF09382.10 EWC46733.1 - 2.5e-18 65.9 0.0 1.1e-17 63.9 0.0 2.1 3 0 0 3 3 3 1 RQC domain Helicase_C PF00271.31 EWC46733.1 - 5.4e-18 65.4 0.0 3.8e-16 59.4 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EWC46733.1 - 4.8e-15 56.0 0.6 1.3e-14 54.6 0.6 1.8 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 EWC46733.1 - 5.6e-08 33.0 0.0 1.2e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HRDC PF00570.23 EWC46733.1 - 0.062 13.3 0.0 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 HRDC domain AAA_22 PF13401.6 EWC46733.1 - 0.069 13.4 0.1 16 5.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain F-box-like PF12937.7 EWC46734.1 - 3.5e-06 26.8 0.0 6.6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC46734.1 - 0.039 13.8 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 F-box domain Kinesin PF00225.23 EWC46735.1 - 1.2e-53 182.2 0.0 1.4e-29 103.1 0.0 2.1 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 EWC46735.1 - 4.7e-11 42.8 0.0 1.1e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding Kelch_4 PF13418.6 EWC46736.1 - 4.6e-07 29.7 14.3 0.0014 18.5 0.5 5.1 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EWC46736.1 - 7.4e-06 25.8 3.4 0.0023 17.9 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 EWC46736.1 - 0.0014 18.9 10.5 1.5 9.2 0.8 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EWC46736.1 - 0.057 13.0 6.5 2.1 8.0 0.1 4.6 5 0 0 5 5 5 0 Kelch motif NICE-1 PF15845.5 EWC46736.1 - 0.063 14.1 0.1 0.16 12.7 0.1 1.7 1 0 0 1 1 1 0 Cysteine-rich C-terminal 1 family Herpes_gE PF02480.16 EWC46736.1 - 0.14 10.9 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E CVNH PF08881.10 EWC46737.1 - 5.4e-11 43.1 0.0 1.4e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 CVNH domain Gly_transf_sug PF04488.15 EWC46738.1 - 7.7e-08 32.9 0.0 1.6e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Glyco_hydro_36N PF16875.5 EWC46738.1 - 0.16 11.5 0.1 1.1 8.7 0.0 2.0 2 0 0 2 2 2 0 Glycosyl hydrolase family 36 N-terminal domain TcdA_TcdB PF12919.7 EWC46738.1 - 0.2 10.9 0.0 0.3 10.3 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Stevor PF17410.2 EWC46739.1 - 0.0023 17.5 2.0 0.0023 17.5 2.0 1.9 1 1 1 2 2 2 1 Subtelomeric Variable Open Reading frame Utp14 PF04615.13 EWC46739.1 - 0.04 12.5 6.8 0.043 12.4 6.8 1.2 1 0 0 1 1 1 0 Utp14 protein DUF347 PF03988.12 EWC46739.1 - 0.1 12.8 0.7 0.1 12.8 0.7 2.6 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) Lin-8 PF03353.15 EWC46739.1 - 4.8 6.7 10.4 7.1 6.1 10.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Proteasome PF00227.26 EWC46740.1 - 1e-46 158.8 0.1 1.2e-46 158.6 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Autoind_bind PF03472.15 EWC46740.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Autoinducer binding domain Mon1 PF03164.14 EWC46742.1 - 1.7e-157 524.6 0.0 2.1e-157 524.4 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Dopey_N PF04118.14 EWC46743.1 - 2.1e-115 385.1 0.4 5.5e-114 380.4 0.0 2.4 2 0 0 2 2 2 2 Dopey, N-terminal CENP-K PF11802.8 EWC46744.1 - 7.2e-08 32.3 6.4 0.04 13.5 9.5 2.5 2 1 0 2 2 2 2 Centromere-associated protein K Rep_fac-A_C PF08646.10 EWC46744.1 - 0.081 12.7 0.2 0.25 11.1 0.0 1.8 2 0 0 2 2 2 0 Replication factor-A C terminal domain DUF745 PF05335.13 EWC46744.1 - 4.9 6.8 9.5 1.4 8.6 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) SlyX PF04102.12 EWC46744.1 - 7.6 7.2 7.3 57 4.4 0.1 2.8 2 0 0 2 2 2 0 SlyX LUC7 PF03194.15 EWC46744.1 - 8 6.0 9.7 0.67 9.6 5.0 1.6 2 0 0 2 2 2 0 LUC7 N_terminus TMPIT PF07851.13 EWC46744.1 - 8.3 5.6 7.9 3.5 6.8 4.2 1.9 2 0 0 2 2 2 0 TMPIT-like protein Pyridoxal_deC PF00282.19 EWC46745.1 - 3.4e-31 108.3 0.0 6.6e-31 107.4 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EWC46745.1 - 0.0092 15.3 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EWC46745.1 - 0.059 12.7 0.0 0.087 12.1 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EWC46745.1 - 0.15 10.9 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V NPP1 PF05630.11 EWC46747.1 - 0.00013 22.1 0.4 0.00013 22.1 0.4 2.2 2 0 0 2 2 2 1 Necrosis inducing protein (NPP1) HA2 PF04408.23 EWC46748.1 - 1.5e-18 67.1 6.4 2.6e-18 66.3 0.0 3.0 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EWC46748.1 - 1.1e-13 51.5 0.0 3.4e-13 49.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EWC46748.1 - 1.1e-07 31.7 0.0 2.3e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EWC46748.1 - 4.2e-05 23.8 0.0 0.00011 22.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 EWC46748.1 - 0.00041 20.6 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC46748.1 - 0.0011 18.8 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EWC46748.1 - 0.039 13.7 0.1 0.099 12.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EWC46748.1 - 0.042 14.4 0.1 0.2 12.1 0.1 2.2 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EWC46748.1 - 0.079 12.9 0.2 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase Transposase_mut PF00872.18 EWC46748.1 - 0.1 11.5 0.0 0.25 10.1 0.0 1.6 2 0 0 2 2 2 0 Transposase, Mutator family AAA_7 PF12775.7 EWC46748.1 - 0.15 11.6 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 EWC46748.1 - 0.39 11.2 4.0 3.1 8.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain BSP_II PF05432.11 EWC46748.1 - 1.4 8.6 9.3 0.061 13.0 2.3 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) CE2_N PF17996.1 EWC46749.1 - 0.00037 20.4 0.0 0.0022 18.0 0.0 2.1 2 0 0 2 2 2 1 Carbohydrate esterase 2 N-terminal GTP_EFTU PF00009.27 EWC46751.1 - 6e-07 29.2 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EWC46751.1 - 0.0014 18.6 0.1 0.52 10.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EWC46751.1 - 0.0034 17.4 0.2 0.0094 16.0 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase KH_1 PF00013.29 EWC46754.1 - 1.1e-28 98.8 9.6 1.3e-18 66.6 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EWC46754.1 - 3e-09 36.6 1.6 0.0018 18.0 0.1 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 EWC46754.1 - 2.2e-05 24.2 1.3 0.057 13.3 0.0 2.6 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 EWC46754.1 - 0.0021 18.0 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 KH-like RNA-binding domain KH_5 PF13184.6 EWC46754.1 - 0.0025 17.8 1.8 0.17 12.0 0.2 2.6 2 0 0 2 2 2 1 NusA-like KH domain MR_MLE_N PF02746.16 EWC46754.1 - 0.11 12.7 0.1 8.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain TMEM154 PF15102.6 EWC46755.1 - 0.052 13.5 0.1 0.62 10.0 0.3 2.1 2 0 0 2 2 2 0 TMEM154 protein family DUF4366 PF14283.6 EWC46755.1 - 0.24 11.4 0.6 13 5.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) Ank_2 PF12796.7 EWC46757.1 - 4.6e-44 148.9 23.8 5.1e-08 33.4 0.0 13.9 5 4 9 17 17 17 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC46757.1 - 6.9e-24 83.9 14.8 0.21 12.2 0.0 14.2 13 2 3 16 16 16 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC46757.1 - 8.2e-20 68.8 14.5 0.92 10.3 0.2 17.7 20 0 0 20 20 20 3 Ankyrin repeat Ank PF00023.30 EWC46757.1 - 2.7e-14 52.9 25.4 0.61 10.6 0.0 17.2 19 1 0 19 19 19 6 Ankyrin repeat Ank_5 PF13857.6 EWC46757.1 - 3.9e-14 52.5 19.7 0.0024 18.1 0.0 12.2 11 2 3 14 14 14 5 Ankyrin repeats (many copies) Fungal_trans PF04082.18 EWC46760.1 - 5.1e-11 42.1 0.1 8.8e-11 41.3 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC46760.1 - 8.4e-08 32.2 9.1 1.5e-07 31.4 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Proteasome PF00227.26 EWC46761.1 - 4.3e-46 156.8 0.1 5.7e-46 156.4 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EWC46761.1 - 9.3e-10 37.8 0.3 9.3e-10 37.8 0.3 2.0 3 0 0 3 3 3 1 Proteasome beta subunits C terminal Cullin PF00888.22 EWC46763.1 - 2.5e-15 56.1 0.0 4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 EWC46763.1 - 1.1e-10 41.8 0.1 3.1e-10 40.4 0.1 1.9 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Astro_capsid_p PF12226.8 EWC46763.1 - 0.005 16.1 0.1 0.005 16.1 0.1 1.7 2 0 0 2 2 2 1 Turkey astrovirus capsid protein GMC_oxred_N PF00732.19 EWC46764.1 - 1.3e-62 211.9 0.0 1.8e-62 211.4 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EWC46764.1 - 1.5e-28 100.2 0.0 3.1e-28 99.1 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EWC46764.1 - 3.2e-05 23.2 1.4 0.0056 15.8 0.3 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EWC46764.1 - 0.00035 20.2 0.3 0.064 12.8 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EWC46764.1 - 0.0011 18.1 0.3 0.0017 17.5 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EWC46764.1 - 0.0017 17.7 1.2 0.49 9.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EWC46764.1 - 0.012 14.8 0.2 0.022 14.0 0.2 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 EWC46764.1 - 0.015 15.5 0.3 0.036 14.3 0.3 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 EWC46764.1 - 0.068 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain FMN_dh PF01070.18 EWC46765.1 - 6.8e-113 377.2 0.0 8e-113 377.0 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EWC46765.1 - 5.8e-05 22.4 0.2 8.1e-05 21.9 0.2 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EWC46765.1 - 0.00015 20.9 0.5 0.00046 19.3 0.3 1.7 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EWC46765.1 - 0.0041 16.5 0.1 0.011 15.1 0.1 1.6 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG IGPS PF00218.21 EWC46765.1 - 0.049 12.8 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase NMO PF03060.15 EWC46765.1 - 0.054 12.9 0.6 0.08 12.3 0.6 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase PMI_typeI PF01238.21 EWC46766.1 - 6.5e-63 213.2 0.0 7.7e-63 212.9 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 EWC46766.1 - 0.0018 17.9 0.2 1.8 8.3 0.0 2.8 3 0 0 3 3 3 2 Cupin domain Herpes_UL87 PF03043.14 EWC46766.1 - 0.0023 16.5 0.6 0.0034 15.9 0.6 1.1 1 0 0 1 1 1 1 Herpesvirus UL87 family RRF PF01765.19 EWC46766.1 - 0.13 12.2 0.5 0.2 11.6 0.5 1.2 1 0 0 1 1 1 0 Ribosome recycling factor Melibiase_2 PF16499.5 EWC46767.1 - 9.7e-60 202.1 3.6 2e-59 201.1 3.6 1.5 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EWC46767.1 - 2.8e-09 36.9 0.1 5.4e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EWC46767.1 - 8.5e-09 34.8 0.0 5.5e-08 32.2 0.0 2.2 3 0 0 3 3 3 1 Melibiase ADIP PF11559.8 EWC46768.1 - 0.0092 16.1 31.9 0.31 11.1 8.2 3.5 2 2 2 4 4 4 4 Afadin- and alpha -actinin-Binding KELK PF15796.5 EWC46768.1 - 0.012 16.1 25.1 0.017 15.6 8.1 4.0 4 0 0 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase PKcGMP_CC PF16808.5 EWC46768.1 - 0.13 12.1 0.4 0.13 12.1 0.4 3.4 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF724 PF05266.14 EWC46768.1 - 0.27 11.1 23.4 0.048 13.5 5.9 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF724) Vac_Fusion PF02346.16 EWC46768.1 - 0.32 10.6 0.1 0.32 10.6 0.1 4.9 3 2 2 5 5 5 0 Chordopoxvirus multifunctional envelope protein A27 DASH_Dad4 PF08650.10 EWC46768.1 - 0.42 10.6 5.1 0.9 9.6 0.0 3.4 3 2 1 4 4 4 0 DASH complex subunit Dad4 UPF0242 PF06785.11 EWC46768.1 - 0.88 9.6 27.2 2.2 8.4 12.4 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus G-gamma PF00631.22 EWC46768.1 - 2.8 8.0 6.4 27 4.9 1.6 3.4 3 0 0 3 3 3 0 GGL domain Cnn_1N PF07989.11 EWC46768.1 - 4.2 7.6 25.2 3.8 7.8 0.6 4.4 4 0 0 4 4 4 0 Centrosomin N-terminal motif 1 PRKG1_interact PF15898.5 EWC46768.1 - 6.8 7.7 26.0 0.99 10.3 5.5 3.5 2 2 2 4 4 4 0 cGMP-dependent protein kinase interacting domain DUF641 PF04859.12 EWC46768.1 - 9 6.6 21.7 3 8.2 0.2 4.2 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EWC46768.1 - 9.6 6.9 25.2 2.4 8.8 0.4 5.2 4 2 2 6 6 6 0 SlyX zf-C2H2_4 PF13894.6 EWC46769.1 - 0.66 11.0 18.4 1.6 9.8 4.5 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger ATP-synt_E PF05680.12 EWC46769.1 - 0.95 9.8 7.1 0.35 11.2 2.1 2.3 2 0 0 2 2 2 0 ATP synthase E chain zf-Mss51 PF13824.6 EWC46769.1 - 1.4 9.0 12.8 56 4.0 8.4 3.6 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 AAA PF00004.29 EWC46772.1 - 7.4e-16 58.8 0.0 1.6e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EWC46772.1 - 0.0038 17.5 2.4 0.068 13.4 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EWC46772.1 - 0.0058 17.0 0.1 0.021 15.2 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EWC46772.1 - 0.0089 16.0 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 EWC46772.1 - 0.059 13.3 0.1 0.31 11.0 0.0 2.2 3 0 0 3 3 3 0 NACHT domain AAA_17 PF13207.6 EWC46772.1 - 0.16 12.4 0.0 0.95 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain NUP214 PF16755.5 EWC46773.1 - 5.3e-12 45.7 0.0 1.1e-10 41.3 0.0 2.1 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Mod_r PF07200.13 EWC46773.1 - 0.62 10.2 15.4 2 8.5 10.7 2.6 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein HGD-D PF06050.13 EWC46775.1 - 0.11 12.3 0.1 0.15 11.8 0.1 1.1 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Baculo_PEP_C PF04513.12 EWC46775.1 - 0.18 11.8 1.7 1.4 9.0 2.0 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CREPT PF16566.5 EWC46775.1 - 0.47 10.6 2.2 5.2 7.2 0.3 2.5 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF948 PF06103.11 EWC46775.1 - 5.5 7.3 6.3 8.7 6.7 1.4 2.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GAS PF13851.6 EWC46777.1 - 0.00019 20.8 8.1 0.00019 20.8 8.1 11.4 4 1 7 12 12 8 3 Growth-arrest specific micro-tubule binding Atg14 PF10186.9 EWC46777.1 - 0.00041 19.5 4.0 0.00041 19.5 4.0 9.9 4 2 7 11 11 9 3 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 EWC46777.1 - 0.00073 18.5 8.5 0.00073 18.5 8.5 10.4 4 1 7 11 11 10 5 Spc7 kinetochore protein ATG16 PF08614.11 EWC46777.1 - 0.001 19.3 21.2 0.001 19.3 21.2 12.1 3 2 9 12 12 7 5 Autophagy protein 16 (ATG16) DUF5082 PF16888.5 EWC46777.1 - 0.0019 18.4 9.3 0.0019 18.4 9.3 11.4 3 1 9 12 12 10 2 Domain of unknown function (DUF5082) DUF1664 PF07889.12 EWC46777.1 - 0.0022 18.0 3.7 0.0022 18.0 3.7 9.9 4 2 7 12 12 12 4 Protein of unknown function (DUF1664) ADIP PF11559.8 EWC46777.1 - 0.0023 18.0 3.4 0.0023 18.0 3.4 13.6 5 1 10 15 15 13 3 Afadin- and alpha -actinin-Binding DUF4472 PF14739.6 EWC46777.1 - 0.0035 18.0 4.5 0.0035 18.0 4.5 13.4 5 1 8 14 14 11 2 Domain of unknown function (DUF4472) PKcGMP_CC PF16808.5 EWC46777.1 - 0.0036 17.1 1.3 0.0036 17.1 1.3 10.9 10 4 3 13 13 12 1 Coiled-coil N-terminus of cGMP-dependent protein kinase RSS_P20 PF11757.8 EWC46777.1 - 0.0041 17.5 1.0 0.0041 17.5 1.0 5.7 5 1 1 6 6 6 1 Suppressor of RNA silencing P21-like N-terminal domain DUF4201 PF13870.6 EWC46777.1 - 0.0046 16.7 8.3 0.0046 16.7 8.3 10.6 5 1 3 10 10 8 4 Domain of unknown function (DUF4201) APG6_N PF17675.1 EWC46777.1 - 0.005 17.4 21.6 0.005 17.4 21.6 14.8 5 3 8 13 13 6 2 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 EWC46777.1 - 0.0073 16.5 12.1 0.0073 16.5 12.1 16.7 4 1 13 17 17 10 3 ABC transporter C-terminal domain TPR_MLP1_2 PF07926.12 EWC46777.1 - 0.0086 16.1 7.2 0.0086 16.1 7.2 13.2 5 1 7 13 13 10 4 TPR/MLP1/MLP2-like protein NTP_transf_9 PF04248.12 EWC46778.1 - 2e-24 85.3 0.0 3.3e-19 68.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF427) DUF2235 PF09994.9 EWC46779.1 - 5.2e-94 314.8 0.0 6.7e-94 314.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Lipase_GDSL_2 PF13472.6 EWC46780.1 - 1.3e-16 61.5 2.6 4.7e-16 59.7 2.6 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EWC46780.1 - 6.9e-14 52.3 0.0 1.2e-13 51.5 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 EWC46780.1 - 0.0014 18.8 0.0 0.0021 18.2 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Pkr1 PF08636.10 EWC46782.1 - 5.5e-27 93.7 0.9 7.1e-27 93.4 0.9 1.1 1 0 0 1 1 1 1 ER protein Pkr1 DUF3959 PF13105.6 EWC46782.1 - 0.089 12.3 2.2 0.098 12.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3959) FAM176 PF14851.6 EWC46782.1 - 0.11 12.2 0.0 0.11 12.2 0.0 2.3 1 1 1 2 2 2 0 FAM176 family Nucleo_P87 PF07267.11 EWC46782.1 - 3.1 6.5 7.4 3.7 6.3 7.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NOA36 PF06524.12 EWC46782.1 - 5.7 6.2 14.5 7.2 5.8 14.5 1.1 1 0 0 1 1 1 0 NOA36 protein Complex1_LYR_2 PF13233.6 EWC46783.1 - 2.5e-21 76.2 0.0 3.7e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EWC46783.1 - 3.3e-10 39.9 0.0 9.3e-10 38.4 0.0 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) LSM PF01423.22 EWC46784.1 - 7.5e-16 57.6 0.4 9.9e-16 57.2 0.4 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EWC46784.1 - 0.0073 16.4 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain SelK_SelG PF10961.8 EWC46784.1 - 0.012 16.2 4.5 0.016 15.8 4.5 1.3 1 0 0 1 1 1 0 Selenoprotein SelK_SelG HlyD_D23 PF16576.5 EWC46784.1 - 0.042 13.1 0.5 0.056 12.7 0.5 1.1 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GLEYA PF10528.9 EWC46787.1 - 4.5e-32 110.3 1.2 1e-31 109.2 0.1 2.3 2 0 0 2 2 2 1 GLEYA domain PAN_1 PF00024.26 EWC46787.1 - 1.8e-12 47.1 12.2 3.5e-06 26.9 3.0 2.5 2 0 0 2 2 2 2 PAN domain PA14 PF07691.12 EWC46787.1 - 5.7e-08 32.7 0.0 2.5e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 PA14 domain PAN_4 PF14295.6 EWC46787.1 - 6.7e-05 22.7 8.2 0.0087 16.0 1.0 2.7 2 0 0 2 2 2 2 PAN domain PAN_3 PF08277.12 EWC46787.1 - 0.00021 21.0 3.9 0.059 13.2 0.3 2.5 2 0 0 2 2 2 2 PAN-like domain MANEC PF07502.14 EWC46787.1 - 0.32 11.3 6.5 1.4 9.2 0.8 2.7 2 0 0 2 2 2 0 MANEC domain PAN_2 PF08276.11 EWC46787.1 - 3.3 7.9 7.6 1.8 8.7 0.8 2.7 2 0 0 2 2 2 0 PAN-like domain NmrA PF05368.13 EWC46788.1 - 7.3e-22 78.1 0.0 1.1e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EWC46788.1 - 4.8e-20 72.2 0.0 8.8e-20 71.4 0.0 1.4 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EWC46788.1 - 5.6e-07 29.9 0.0 8.7e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 EWC46788.1 - 4.7e-06 26.7 0.1 9.4e-06 25.8 0.1 1.5 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EWC46788.1 - 2.2e-05 24.1 0.2 3.6e-05 23.3 0.2 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EWC46788.1 - 0.00085 18.4 0.1 0.0033 16.5 0.1 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GFO_IDH_MocA PF01408.22 EWC46788.1 - 0.0012 19.7 0.1 0.0019 19.0 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EWC46788.1 - 0.0033 17.9 0.1 0.0057 17.1 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain CoA_binding PF02629.19 EWC46788.1 - 0.0083 16.8 1.6 0.02 15.5 1.6 1.6 1 1 0 1 1 1 1 CoA binding domain NAD_binding_4 PF07993.12 EWC46788.1 - 0.037 13.2 0.0 0.061 12.5 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein TrkA_N PF02254.18 EWC46788.1 - 0.08 13.2 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain CoA_binding_2 PF13380.6 EWC46788.1 - 0.11 12.9 0.1 0.21 12.1 0.1 1.4 1 0 0 1 1 1 0 CoA binding domain Zn_clus PF00172.18 EWC46789.1 - 4.3e-07 29.9 25.0 5e-06 26.5 6.2 2.2 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Rad51 PF08423.11 EWC46790.1 - 0.38 10.0 2.4 0.24 10.6 0.6 1.6 2 0 0 2 2 2 0 Rad51 LemA PF04011.12 EWC46790.1 - 0.76 9.6 14.5 4.5 7.1 0.4 3.3 2 1 1 3 3 3 0 LemA family AAA_13 PF13166.6 EWC46790.1 - 2.3 6.8 13.9 1.1 7.8 9.3 2.0 2 0 0 2 2 2 0 AAA domain MPS2 PF17060.5 EWC46790.1 - 6 6.0 10.5 1.4 8.1 6.2 1.9 2 0 0 2 2 2 0 Monopolar spindle protein 2 DJ-1_PfpI PF01965.24 EWC46791.1 - 8e-15 55.0 0.1 5e-07 29.7 0.0 2.2 2 0 0 2 2 2 2 DJ-1/PfpI family GATase_5 PF13507.6 EWC46791.1 - 0.073 12.2 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Glyco_hydro_31 PF01055.26 EWC46792.1 - 1.2e-141 472.9 5.5 1.4e-141 472.7 5.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EWC46792.1 - 1.5e-29 102.6 0.0 2.8e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EWC46792.1 - 3e-06 27.4 0.8 3e-06 27.4 0.8 2.7 3 0 0 3 3 3 1 Galactose mutarotase-like zf-C2H2_4 PF13894.6 EWC46794.1 - 0.00014 22.4 3.4 0.015 16.0 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EWC46794.1 - 0.0041 17.0 0.3 0.0084 16.0 0.3 1.5 1 0 0 1 1 1 1 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 EWC46794.1 - 0.0049 16.8 1.6 0.0094 15.9 1.6 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EWC46794.1 - 0.031 14.7 0.5 0.031 14.7 0.5 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC46794.1 - 2.5 8.7 7.2 0.12 12.8 1.3 1.9 2 0 0 2 2 2 0 Zinc-finger double domain NMO PF03060.15 EWC46796.1 - 1.3e-44 153.0 1.9 2e-42 145.8 1.3 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 EWC46796.1 - 1.7e-10 40.5 1.2 8.5e-10 38.2 1.2 1.8 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EWC46796.1 - 0.0021 17.2 2.3 0.0037 16.4 2.3 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase FAD_binding_3 PF01494.19 EWC46797.1 - 1.6e-43 149.3 0.0 2.1e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EWC46797.1 - 2.2e-06 27.1 0.1 3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC46797.1 - 4e-06 26.7 1.4 0.00011 21.9 0.2 2.5 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EWC46797.1 - 8.8e-06 24.7 0.0 1.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 EWC46797.1 - 9.4e-06 25.8 0.0 2.8e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EWC46797.1 - 3.6e-05 23.0 0.1 5.8e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EWC46797.1 - 0.00051 19.2 0.0 0.00088 18.4 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EWC46797.1 - 0.00078 18.8 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EWC46797.1 - 0.0046 16.1 0.1 0.0089 15.1 0.1 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EWC46797.1 - 0.0069 15.7 0.1 0.013 14.8 0.1 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EWC46797.1 - 0.056 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EWC46797.1 - 0.079 13.5 0.0 0.2 12.3 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Asp PF00026.23 EWC46798.1 - 1.1e-28 100.6 0.0 5.3e-14 52.4 0.1 2.2 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 EWC46798.1 - 0.00018 21.8 0.0 0.0012 19.2 0.0 2.2 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EWC46798.1 - 0.00041 20.9 0.0 0.044 14.4 0.0 2.5 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EWC46798.1 - 0.013 16.1 0.1 0.58 10.8 0.0 2.6 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease Chromate_transp PF02417.15 EWC46799.1 - 7.2e-60 201.7 40.6 2.1e-34 118.9 14.8 2.4 3 0 0 3 3 3 2 Chromate transporter TMP_2 PF06791.13 EWC46799.1 - 1.8 8.2 5.9 0.39 10.4 0.4 2.2 2 0 0 2 2 2 0 Prophage tail length tape measure protein TPR_1 PF00515.28 EWC46801.1 - 1.2e-12 47.1 12.8 0.058 13.2 0.0 9.7 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 EWC46801.1 - 4e-12 46.5 0.7 0.029 14.9 0.0 7.7 7 2 2 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC46801.1 - 5e-12 45.9 2.2 0.0089 16.2 0.0 5.4 6 0 0 6 6 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EWC46801.1 - 1.5e-11 44.1 6.7 0.21 12.5 0.0 8.2 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46801.1 - 6.2e-11 41.5 15.5 2.1 8.6 0.0 10.6 12 0 0 12 12 10 2 Tetratricopeptide repeat TPR_9 PF13371.6 EWC46801.1 - 2.7e-08 33.8 0.8 0.31 11.2 0.0 5.9 7 1 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EWC46801.1 - 5.5e-08 33.3 10.5 2.5 8.8 0.0 7.3 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EWC46801.1 - 2.4e-07 30.4 2.9 5.3 7.5 0.0 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EWC46801.1 - 1e-06 28.3 0.5 0.051 13.3 0.1 6.2 6 0 0 6 6 6 1 TPR repeat TPR_17 PF13431.6 EWC46801.1 - 5.6e-06 26.4 1.1 0.017 15.4 0.0 5.6 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC46801.1 - 0.008 16.4 15.0 34 4.8 0.2 8.5 7 3 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 EWC46801.1 - 0.015 15.3 4.1 1.4e+02 2.9 0.1 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EWC46801.1 - 0.031 14.3 1.6 57 3.9 0.0 4.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat SDA1 PF05285.12 EWC46801.1 - 0.17 11.3 5.0 0.3 10.5 5.0 1.4 1 0 0 1 1 1 0 SDA1 TPR_6 PF13174.6 EWC46801.1 - 0.18 12.5 18.9 29 5.6 0.0 8.7 10 0 0 10 10 8 0 Tetratricopeptide repeat YL1 PF05764.13 EWC46801.1 - 1.8 8.6 17.8 0.037 14.2 8.9 2.3 3 0 0 3 3 3 0 YL1 nuclear protein Nop14 PF04147.12 EWC46801.1 - 3.6 5.7 7.6 7 4.7 7.6 1.4 1 0 0 1 1 1 0 Nop14-like family Ribosomal_L29e PF01779.17 EWC46802.1 - 1.8e-22 79.4 8.2 2.5e-22 78.9 8.2 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family Ribosomal_L11_N PF03946.14 EWC46803.1 - 7.2e-24 83.4 0.2 1.1e-23 82.8 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EWC46803.1 - 5.2e-15 55.7 0.4 9.3e-15 54.9 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain IF2_N PF04760.15 EWC46803.1 - 0.063 13.1 0.2 0.18 11.7 0.1 2.0 1 1 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region WD40 PF00400.32 EWC46804.1 - 2.1e-05 25.2 1.9 0.066 14.1 0.0 5.2 5 1 0 5 5 5 1 WD domain, G-beta repeat LisH PF08513.11 EWC46804.1 - 4.4e-05 23.3 0.1 7.8e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 LisH DUF4201 PF13870.6 EWC46805.1 - 0.21 11.3 0.0 0.36 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Acetyltransf_1 PF00583.25 EWC46806.1 - 5.1e-12 46.1 0.0 7.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC46806.1 - 1.1e-08 35.1 0.0 1.5e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC46806.1 - 6.3e-07 29.7 0.0 9.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EWC46806.1 - 3.8e-06 26.8 0.1 6.5e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein SAM_2 PF07647.17 EWC46807.1 - 6.9e-09 35.7 0.1 1.3e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EWC46807.1 - 1.1e-05 25.7 0.1 2.3e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 EWC46807.1 - 0.007 16.4 0.1 0.024 14.7 0.1 1.9 1 0 0 1 1 1 1 IGR protein motif DUF4508 PF14969.6 EWC46807.1 - 0.16 12.2 0.1 0.32 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) TFIID-31kDa PF02291.15 EWC46807.1 - 0.31 11.1 2.0 0.31 11.1 0.0 2.0 3 0 0 3 3 3 0 Transcription initiation factor IID, 31kD subunit Wtap PF17098.5 EWC46807.1 - 0.34 10.8 1.6 0.69 9.8 1.4 1.5 1 1 0 1 1 1 0 WTAP/Mum2p family HET PF06985.11 EWC46808.1 - 3.7e-09 37.1 1.3 5.8e-07 30.0 0.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Arf PF00025.21 EWC46809.1 - 1.2e-42 145.3 0.0 1.4e-42 145.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EWC46809.1 - 3.5e-19 69.0 0.0 4.1e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC46809.1 - 1.3e-16 60.9 0.0 1.9e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EWC46809.1 - 4.7e-08 32.7 0.0 5.2e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EWC46809.1 - 9.9e-07 28.8 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EWC46809.1 - 2.5e-05 23.7 0.0 3.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EWC46809.1 - 0.00011 21.5 0.1 0.00047 19.4 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit FeoB_N PF02421.18 EWC46809.1 - 0.035 13.6 0.4 0.11 12.1 0.4 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EWC46809.1 - 0.045 13.8 0.0 0.39 10.7 0.1 2.0 1 1 1 2 2 2 0 Dynamin family PP1_inhibitor PF05361.12 EWC46809.1 - 0.057 13.4 0.3 0.081 12.9 0.3 1.3 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor ATP_bind_1 PF03029.17 EWC46809.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.4 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Med14 PF08638.11 EWC46810.1 - 3.8e-59 199.3 0.0 7.7e-59 198.3 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 Glyco_hydro_61 PF03443.14 EWC46811.1 - 3e-58 197.1 0.0 5.4e-58 196.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EWC46811.1 - 0.00014 21.7 5.7 0.00014 21.7 5.7 2.1 2 0 0 2 2 2 1 Fungal cellulose binding domain ATG22 PF11700.8 EWC46812.1 - 2.6e-180 600.2 7.4 2.9e-180 600.0 7.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Hum_adeno_E3A PF05393.11 EWC46812.1 - 0.25 11.3 2.2 4.9 7.2 0.1 2.9 3 0 0 3 3 3 0 Human adenovirus early E3A glycoprotein F-box-like PF12937.7 EWC46813.1 - 1.8e-08 34.1 1.3 3.9e-08 33.1 1.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC46813.1 - 0.00012 21.9 0.7 0.00024 20.9 0.7 1.5 1 0 0 1 1 1 1 F-box domain MIT PF04212.18 EWC46813.1 - 0.041 14.0 0.1 0.079 13.0 0.1 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain PXA PF02194.15 EWC46814.1 - 1.1e-23 84.1 2.1 8.3e-23 81.3 0.7 2.3 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EWC46814.1 - 3e-20 72.9 1.4 9.6e-20 71.2 0.5 2.3 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 EWC46814.1 - 0.019 14.9 0.0 0.051 13.6 0.0 1.7 1 0 0 1 1 1 0 PX domain Prp18 PF02840.15 EWC46814.1 - 0.062 13.3 0.3 0.36 10.9 0.2 2.2 2 0 0 2 2 2 0 Prp18 domain eIF-3c_N PF05470.12 EWC46815.1 - 0.074 11.3 0.0 0.083 11.2 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SPC25 PF06703.11 EWC46816.1 - 0.022 14.6 1.5 0.058 13.2 0.5 2.0 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4191 PF13829.6 EWC46816.1 - 0.11 11.9 7.2 1.2 8.5 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) COX2_TM PF02790.15 EWC46816.1 - 0.92 9.7 0.0 0.92 9.7 0.0 3.0 3 1 1 4 4 4 0 Cytochrome C oxidase subunit II, transmembrane domain SpoIIM PF01944.17 EWC46816.1 - 7 6.7 13.3 32 4.5 11.3 2.6 2 1 0 2 2 2 0 Stage II sporulation protein M TPP_enzyme_N PF02776.18 EWC46817.1 - 4.4e-30 104.5 0.0 7.4e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EWC46817.1 - 8.4e-23 80.6 0.0 2.2e-22 79.3 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EWC46817.1 - 3e-19 69.3 0.0 6.8e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EWC46817.1 - 0.0015 17.8 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase RSS_P20 PF11757.8 EWC46817.1 - 0.11 13.0 0.0 0.46 11.0 0.0 2.0 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain ATP12 PF07542.11 EWC46818.1 - 0.00048 20.2 0.0 0.00072 19.6 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein ATP12 PF07542.11 EWC46819.1 - 1.4e-25 89.9 0.0 1.8e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 ATP12 chaperone protein zf-C3HC PF07967.13 EWC46820.1 - 8.6e-40 135.9 0.5 4.7e-31 107.6 0.0 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 EWC46820.1 - 1.5e-22 79.5 2.9 2.3e-22 78.9 0.1 2.7 3 0 0 3 3 3 1 Rsm1-like BIR PF00653.21 EWC46820.1 - 0.0042 17.7 0.2 6.8 7.4 0.0 2.8 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain DMPK_coil PF08826.10 EWC46820.1 - 0.1 12.7 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 DMPK coiled coil domain like E1_dh PF00676.20 EWC46821.1 - 5.5e-95 317.8 0.1 7.5e-95 317.3 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EWC46821.1 - 0.087 12.0 0.0 0.28 10.3 0.0 1.7 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase TAT_signal PF10518.9 EWC46822.1 - 9 6.3 6.5 23 5.0 6.5 1.7 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence KH_8 PF17903.1 EWC46823.1 - 1.1e-28 99.2 0.0 2.4e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EWC46823.1 - 0.0045 16.8 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 KH domain Proteasome PF00227.26 EWC46824.1 - 3.3e-58 196.3 0.2 4e-58 196.1 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EWC46824.1 - 2.8e-13 49.3 0.1 8.6e-13 47.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Nitrate_red_gam PF02665.14 EWC46824.1 - 0.0027 17.3 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 Nitrate reductase gamma subunit DUF5624 PF18538.1 EWC46824.1 - 0.031 14.4 0.3 0.088 12.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) ODV-E18 PF10717.9 EWC46825.1 - 0.22 11.4 6.0 0.21 11.5 5.0 1.5 1 1 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ATP-synt_8 PF00895.20 EWC46825.1 - 0.7 10.4 5.6 0.41 11.2 3.3 1.7 1 1 1 2 2 2 0 ATP synthase protein 8 Ubie_methyltran PF01209.18 EWC46827.1 - 8.8e-85 283.7 0.1 1.1e-84 283.4 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EWC46827.1 - 3.3e-14 53.3 0.0 6.6e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC46827.1 - 1.5e-12 47.5 0.0 3.7e-12 46.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC46827.1 - 2.1e-11 44.3 0.0 3.7e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC46827.1 - 5.2e-07 30.3 0.0 1.4e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC46827.1 - 6.3e-06 26.1 0.0 1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 EWC46827.1 - 0.017 14.2 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_32 PF13679.6 EWC46827.1 - 0.019 15.0 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EWC46827.1 - 0.16 13.0 0.0 0.38 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain FF PF01846.19 EWC46828.1 - 3.5e-10 39.9 6.4 8.7e-10 38.6 0.0 3.4 3 0 0 3 3 3 1 FF domain WW PF00397.26 EWC46828.1 - 6e-09 35.8 14.7 4.2e-07 29.9 1.1 3.3 4 0 0 4 4 4 2 WW domain DUF16 PF01519.16 EWC46828.1 - 0.17 12.4 5.7 0.46 11.0 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF2462 PF09495.10 EWC46829.1 - 4e-21 75.5 7.7 4e-21 75.5 7.7 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) Aminotran_1_2 PF00155.21 EWC46830.1 - 2.5e-11 43.3 0.0 3.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EWC46830.1 - 0.0012 17.7 0.0 0.0036 16.1 0.0 1.7 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase HhH-GPD PF00730.25 EWC46831.1 - 2e-06 28.2 0.0 3.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Peptidase_M3 PF01432.20 EWC46832.1 - 2.6e-92 310.5 0.0 3.1e-92 310.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 EWC46832.1 - 0.014 15.7 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Effector protein Peptidase_M50B PF13398.6 EWC46832.1 - 0.034 13.8 1.0 0.063 12.9 1.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like AA_kinase PF00696.28 EWC46833.1 - 7.8e-40 137.0 0.1 2e-39 135.7 0.0 1.7 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 EWC46833.1 - 8.3e-12 44.7 0.3 2.3e-07 30.4 0.1 2.6 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 EWC46833.1 - 2e-08 33.9 4.5 6.9e-08 32.2 0.3 3.1 3 0 0 3 3 3 1 ACT domain DUF1604 PF07713.13 EWC46834.1 - 4.1e-39 132.3 0.5 4.1e-39 132.3 0.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EWC46834.1 - 5.4e-06 26.2 2.1 5.4e-06 26.2 2.1 2.3 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EWC46834.1 - 4e-05 23.6 1.7 0.015 15.4 0.1 3.2 2 0 0 2 2 2 2 G-patch domain Ku PF02735.16 EWC46835.1 - 2.8e-45 154.5 0.0 4.4e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EWC46835.1 - 4.3e-27 95.3 0.0 6.6e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EWC46835.1 - 2e-22 79.7 1.3 5.1e-22 78.4 0.1 2.3 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EWC46835.1 - 1.1e-10 41.0 0.0 1.9e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 SAP domain HeH PF12949.7 EWC46835.1 - 0.011 15.4 0.0 0.029 14.1 0.0 1.7 1 0 0 1 1 1 0 HeH/LEM domain PX PF00787.24 EWC46836.1 - 7e-19 67.9 0.3 1.9e-18 66.5 0.3 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EWC46836.1 - 6.1e-07 29.2 7.6 0.0013 18.3 2.7 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.18 EWC46836.1 - 0.0026 17.4 6.6 0.048 13.3 0.4 2.7 3 0 0 3 3 3 2 BAR domain HMMR_N PF15905.5 EWC46836.1 - 0.13 11.7 0.1 0.13 11.7 0.1 2.0 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal CCDC106 PF15794.5 EWC46836.1 - 0.17 11.6 3.3 0.38 10.4 3.3 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Actin PF00022.19 EWC46837.1 - 2.2e-33 115.5 0.0 1.1e-21 76.9 0.0 3.1 3 0 0 3 3 3 3 Actin Lyase_1 PF00206.20 EWC46838.1 - 1.3e-97 327.0 0.0 4.8e-97 325.1 0.0 1.7 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.6 EWC46838.1 - 7.1e-23 81.2 0.0 1.6e-22 80.0 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal FKBP_C PF00254.28 EWC46839.1 - 1.8e-29 101.9 0.0 2.1e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Arf PF00025.21 EWC46840.1 - 4.8e-42 143.4 0.0 6.4e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EWC46840.1 - 3e-14 52.9 0.0 4.5e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC46840.1 - 4.5e-13 49.5 0.0 6.8e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EWC46840.1 - 8e-11 41.7 0.0 2.1e-10 40.3 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EWC46840.1 - 2.7e-10 40.0 0.1 0.00017 20.9 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EWC46840.1 - 3.4e-08 33.1 0.0 5.8e-08 32.4 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EWC46840.1 - 1.5e-05 24.6 0.0 0.0014 18.2 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EWC46840.1 - 1.9e-05 24.7 0.0 3.9e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EWC46840.1 - 0.0012 19.1 0.0 0.037 14.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain Glyco_hydro_32C PF08244.12 EWC46842.1 - 0.048 13.7 0.0 0.06 13.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 C terminal ApbA_C PF08546.11 EWC46844.1 - 3.2e-32 111.4 0.2 5.4e-32 110.6 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EWC46844.1 - 2.1e-28 98.9 0.0 2.9e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DUF2884 PF11101.8 EWC46844.1 - 0.097 12.2 0.0 4.1 6.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) Sas10_Utp3 PF04000.15 EWC46845.1 - 1.4e-17 64.1 1.3 4.8e-17 62.3 1.3 2.0 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Aminotran_1_2 PF00155.21 EWC46846.1 - 5.9e-81 272.4 0.0 6.7e-81 272.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II FAM176 PF14851.6 EWC46847.1 - 0.47 10.1 2.8 1.9 8.2 2.8 2.0 1 0 0 1 1 1 0 FAM176 family LtrA PF06772.11 EWC46848.1 - 1.1e-27 97.2 16.8 1.1e-27 97.2 16.8 1.9 2 0 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) DUF2304 PF10066.9 EWC46848.1 - 6 7.1 12.8 0.47 10.7 3.9 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) TP6A_N PF04406.14 EWC46850.1 - 8.2e-12 44.9 0.0 1.6e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Hirudin PF00713.17 EWC46850.1 - 0.026 14.8 0.4 0.078 13.3 0.4 1.7 1 0 0 1 1 1 0 Hirudin HTH_23 PF13384.6 EWC46850.1 - 0.054 13.3 0.0 0.36 10.7 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain baeRF_family10 PF18854.1 EWC46850.1 - 1.6 8.9 5.4 14 5.9 3.9 2.2 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 Exo5 PF09810.9 EWC46851.1 - 1.3e-104 350.6 0.9 8.6e-104 347.9 0.0 2.4 2 1 0 2 2 2 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EWC46851.1 - 6.9e-05 22.9 0.0 0.0081 16.1 0.1 3.2 2 1 0 2 2 2 1 PD-(D/E)XK nuclease superfamily Glyco_transf_21 PF13506.6 EWC46852.1 - 8.2e-21 74.2 0.0 3.8e-10 39.5 0.0 3.3 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EWC46852.1 - 6.7e-10 39.2 0.0 1.1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EWC46852.1 - 0.00067 19.5 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EWC46852.1 - 0.067 13.1 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Glycosyl transferase family group 2 His_Phos_1 PF00300.22 EWC46853.1 - 5.5e-28 98.0 0.4 8.5e-28 97.4 0.4 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF1153 PF06627.11 EWC46853.1 - 0.0018 18.4 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1153) Glyco_transf_90 PF05686.12 EWC46854.1 - 2.4e-12 46.5 7.4 6.4e-10 38.5 3.6 3.1 2 2 0 2 2 2 2 Glycosyl transferase family 90 LRR_4 PF12799.7 EWC46855.1 - 7.1e-07 29.5 0.2 0.018 15.4 0.2 3.3 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EWC46855.1 - 2.3e-06 27.2 2.0 0.44 10.7 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich repeat LRR_8 PF13855.6 EWC46855.1 - 7.3e-05 22.5 1.7 0.64 9.8 0.0 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EWC46855.1 - 0.0058 17.0 1.7 5.5 7.9 0.0 4.2 2 1 0 2 2 2 1 Leucine Rich Repeat Methyltransf_28 PF02636.17 EWC46856.1 - 8.2e-75 251.8 0.0 1e-74 251.5 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase ACBP PF00887.19 EWC46857.1 - 3.4e-23 81.7 0.0 7.1e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein Paf1 PF03985.13 EWC46858.1 - 3.5e-66 224.0 0.0 4.3e-66 223.7 0.0 1.0 1 0 0 1 1 1 1 Paf1 Coatomer_E PF04733.14 EWC46859.1 - 9e-63 212.4 5.1 1e-62 212.2 5.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EWC46859.1 - 5.9e-07 29.9 9.4 0.011 16.2 0.5 4.1 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EWC46859.1 - 8.2e-06 26.4 3.2 0.15 12.7 0.0 4.3 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46859.1 - 1.6e-05 24.7 2.1 0.13 12.4 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC46859.1 - 2.6e-05 23.9 0.1 0.43 10.5 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC46859.1 - 7.3e-05 23.0 0.8 0.14 12.4 0.1 3.4 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC46859.1 - 7.7e-05 23.2 10.5 0.35 11.8 0.1 5.2 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 EWC46859.1 - 0.0053 17.3 4.1 4.8 8.1 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EWC46859.1 - 0.0063 16.6 0.5 2.2 8.5 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EWC46859.1 - 0.0064 16.6 0.5 0.46 10.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EWC46859.1 - 0.0079 15.9 3.7 0.68 9.7 0.1 3.7 4 0 0 4 4 4 1 TPR repeat TPR_10 PF13374.6 EWC46859.1 - 0.0082 16.0 1.9 13 5.9 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EWC46859.1 - 0.13 13.0 1.5 1.3e+02 3.6 0.0 4.5 5 1 0 5 5 3 0 Tetratricopeptide repeat HSCB_C PF07743.13 EWC46859.1 - 6.6 7.3 8.6 8.6 6.9 3.4 2.8 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain GCP_N_terminal PF17681.1 EWC46860.1 - 5.6e-31 108.3 0.0 2e-30 106.5 0.0 1.8 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EWC46860.1 - 3.6e-22 79.2 1.2 5.5e-16 58.9 0.1 2.7 3 1 0 3 3 3 2 Gamma tubulin complex component C-terminal SDA1 PF05285.12 EWC46860.1 - 0.00022 20.7 5.5 0.00022 20.7 5.5 2.0 2 0 0 2 2 2 1 SDA1 BUD22 PF09073.10 EWC46860.1 - 0.00059 19.3 6.7 0.00059 19.3 6.7 1.8 2 0 0 2 2 2 1 BUD22 TRAP_alpha PF03896.16 EWC46860.1 - 0.54 9.4 7.6 0.96 8.6 7.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NPR3 PF03666.13 EWC46860.1 - 1.5 7.5 2.8 2.6 6.7 2.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RXT2_N PF08595.11 EWC46860.1 - 1.7 8.6 11.0 6 6.9 11.0 1.9 1 0 0 1 1 1 0 RXT2-like, N-terminal TCO89 PF10452.9 EWC46861.1 - 6.7e-07 28.7 7.4 7.2e-05 22.0 0.0 2.6 2 0 0 2 2 2 2 TORC1 subunit TCO89 TcA_TcB_BD PF18276.1 EWC46862.1 - 1.4e-112 375.5 0.7 2.3e-112 374.8 0.7 1.4 1 0 0 1 1 1 1 Tc toxin complex TcA C-terminal TcB-binding domain Neuraminidase PF18413.1 EWC46862.1 - 2.3e-27 95.7 3.8 2.3e-27 95.7 3.8 1.8 2 0 0 2 2 2 1 Neuraminidase-like domain VRP1 PF03538.14 EWC46862.1 - 6.4e-08 32.4 0.6 3.1e-06 26.8 0.0 3.1 3 0 0 3 3 3 1 Salmonella virulence plasmid 28.1kDa A protein CarboxypepD_reg PF13620.6 EWC46862.1 - 0.026 14.8 0.0 0.096 13.0 0.0 2.0 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain HalOD1 PF18545.1 EWC46862.1 - 0.09 13.1 0.6 0.44 10.9 0.0 2.4 2 0 0 2 2 2 0 Halobacterial output domain 1 DSHCT PF08148.12 EWC46862.1 - 0.23 11.1 0.5 2.1 8.0 0.1 2.8 3 0 0 3 3 3 0 DSHCT (NUC185) domain UCH_1 PF13423.6 EWC46864.1 - 2.2e-97 326.5 0.6 4.1e-97 325.6 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EWC46864.1 - 1.2e-24 87.7 0.0 2.2e-24 86.9 0.0 1.4 1 0 0 1 1 1 1 Exonuclease ANAPC4_WD40 PF12894.7 EWC46864.1 - 0.021 15.1 0.0 11 6.5 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain TFIIA PF03153.13 EWC46864.1 - 0.17 11.9 14.4 0.26 11.2 14.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 EWC46864.1 - 9.4 5.6 20.1 17 4.7 20.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region IPU_b_solenoid PF18783.1 EWC46865.1 - 0.21 11.6 0.1 1.1 9.4 0.0 2.0 2 0 0 2 2 2 0 Isopullulanase beta-solenoid repeat Rad4 PF03835.15 EWC46866.1 - 1.2e-29 102.8 0.1 4.1e-29 101.2 0.1 1.9 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EWC46866.1 - 1.4e-23 83.1 0.0 2.7e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EWC46866.1 - 6.2e-17 61.2 0.0 1.2e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EWC46866.1 - 1.2e-15 58.2 1.5 1.2e-15 58.2 1.5 3.9 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Tht1 PF04163.12 EWC46867.1 - 1.1e-17 64.0 2.0 1.5e-17 63.6 2.0 1.2 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein Fe_dep_repr_C PF02742.15 EWC46867.1 - 0.024 14.7 1.2 0.067 13.3 0.2 2.4 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain Band_7 PF01145.25 EWC46868.1 - 8.1e-23 81.3 2.1 1.3e-22 80.6 2.1 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family IBR PF01485.21 EWC46869.1 - 1.4e-17 63.6 32.5 1.9e-11 44.0 3.8 3.6 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain RWD PF05773.22 EWC46869.1 - 1.7e-10 41.2 0.0 3.4e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EWC46869.1 - 3.6e-05 24.0 5.1 3.6e-05 24.0 5.1 4.1 3 2 1 4 4 4 2 Ring finger domain zf-C3HC4 PF00097.25 EWC46869.1 - 0.0001 22.1 4.5 0.0001 22.1 4.5 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC46869.1 - 0.00015 21.7 5.6 0.00015 21.7 5.6 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 EWC46869.1 - 0.0037 17.2 6.1 0.0037 17.2 6.1 3.8 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EWC46869.1 - 0.0047 16.7 5.0 0.0047 16.7 5.0 4.1 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Gly_transf_sug PF04488.15 EWC46870.1 - 1.6e-08 35.0 0.0 3.5e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Complex1_30kDa PF00329.19 EWC46871.1 - 1.6e-44 151.4 0.0 2.2e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit zf-RING_4 PF14570.6 EWC46872.1 - 1.1e-19 70.0 12.8 2e-19 69.1 12.8 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EWC46872.1 - 1.6e-08 34.3 0.0 8.3e-08 32.0 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EWC46872.1 - 4.6e-06 26.4 7.4 4.6e-06 26.4 7.4 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 EWC46872.1 - 0.00028 20.9 5.0 0.00051 20.0 5.0 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_2 PF13639.6 EWC46872.1 - 0.0018 18.6 10.6 0.0039 17.5 10.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-UDP PF14569.6 EWC46872.1 - 0.0054 16.8 5.0 0.0054 16.8 5.0 1.9 2 0 0 2 2 2 1 Zinc-binding RING-finger Prok-RING_4 PF14447.6 EWC46872.1 - 0.016 15.0 7.4 0.17 11.8 7.6 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EWC46872.1 - 0.018 14.9 11.3 0.039 13.8 11.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SET_assoc PF11767.8 EWC46872.1 - 0.02 14.5 0.0 0.047 13.3 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated FYVE PF01363.21 EWC46872.1 - 1.1 9.4 5.8 2.7 8.2 5.8 1.6 1 0 0 1 1 1 0 FYVE zinc finger zf-RING_UBOX PF13445.6 EWC46872.1 - 3.1 7.9 7.9 5 7.2 6.8 2.0 1 1 1 2 2 2 0 RING-type zinc-finger Egh16-like PF11327.8 EWC46874.1 - 9.9e-36 123.9 0.0 1.6e-35 123.2 0.0 1.3 1 0 0 1 1 1 1 Egh16-like virulence factor Tub_N PF16322.5 EWC46874.1 - 0.028 14.8 5.3 0.048 14.1 5.3 1.3 1 0 0 1 1 1 0 Tubby N-terminal RNA_pol_3_Rpc31 PF11705.8 EWC46874.1 - 0.039 14.2 21.6 0.072 13.3 21.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 EWC46874.1 - 0.14 11.4 27.1 0.22 10.8 27.1 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EWC46874.1 - 0.26 9.5 13.0 0.33 9.2 13.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1168 PF06658.12 EWC46874.1 - 1.7 8.5 13.2 3.3 7.5 13.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DUF1754 PF08555.10 EWC46874.1 - 1.9 9.4 18.7 4.1 8.3 18.7 1.6 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Cwf_Cwc_15 PF04889.12 EWC46874.1 - 1.9 8.2 25.7 3.2 7.4 25.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PPL5 PF18168.1 EWC46874.1 - 3.1 7.0 8.5 4.8 6.4 8.5 1.2 1 0 0 1 1 1 0 Prim-pol family 5 TFIIF_alpha PF05793.12 EWC46874.1 - 8.8 4.8 29.4 13 4.2 29.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) COesterase PF00135.28 EWC46875.1 - 1e-74 252.3 0.0 1.2e-74 252.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EWC46875.1 - 0.0021 17.9 0.6 0.016 15.0 0.6 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Nup160 PF11715.8 EWC46876.1 - 0.035 12.7 0.0 0.75 8.4 0.0 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Gly_rich_SFCGS PF14272.6 EWC46876.1 - 0.08 13.0 0.2 0.08 13.0 0.2 1.8 2 0 0 2 2 2 0 Glycine-rich SFCGS Flavoprotein PF02441.19 EWC46876.1 - 0.092 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Flavoprotein FtsJ PF01728.19 EWC46877.1 - 3e-68 229.4 0.0 3.6e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase ATG13 PF10033.9 EWC46878.1 - 3.2e-66 223.4 0.1 4.5e-66 223.0 0.1 1.2 1 0 0 1 1 1 1 Autophagy-related protein 13 Beta-lactamase PF00144.24 EWC46879.1 - 0.12 11.6 0.2 0.17 11.1 0.2 1.2 1 0 0 1 1 1 0 Beta-lactamase NitrOD2 PF18550.1 EWC46879.1 - 0.15 12.2 0.0 2.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Nitrososphaera output domain 2 Filament PF00038.21 EWC46880.1 - 6e-09 35.9 119.8 0.0033 17.0 40.8 5.5 1 1 2 4 4 4 4 Intermediate filament protein DUF812 PF05667.11 EWC46880.1 - 0.00016 20.7 13.6 0.00016 20.7 13.6 4.7 1 1 4 5 5 5 1 Protein of unknown function (DUF812) KASH_CCD PF14662.6 EWC46880.1 - 0.00074 19.4 20.2 0.00074 19.4 20.2 6.4 2 2 4 6 6 6 1 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 EWC46880.1 - 0.0092 14.9 149.8 0.44 9.4 25.1 7.5 1 1 6 8 8 8 7 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EWC46880.1 - 0.15 12.1 143.3 0.012 15.7 19.3 8.9 1 1 6 8 8 8 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PKcGMP_CC PF16808.5 EWC46880.1 - 0.43 10.5 18.4 0.97 9.3 0.0 5.5 5 0 0 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Leucyl-specific PF14795.6 EWC46880.1 - 1.1 9.4 3.2 4.4 7.4 0.3 3.6 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain CEP63 PF17045.5 EWC46880.1 - 3.7 7.4 121.7 0.045 13.7 28.2 4.8 1 1 3 4 4 4 0 Centrosomal protein of 63 kDa FAM184 PF15665.5 EWC46880.1 - 4.5 7.0 138.0 0.019 14.8 28.7 6.8 1 1 5 6 6 6 0 Family with sequence similarity 184, A and B BUD22 PF09073.10 EWC46881.1 - 1.1e-68 232.6 15.8 1.1e-68 232.6 15.8 2.7 2 1 0 2 2 2 1 BUD22 SIR2 PF02146.17 EWC46882.1 - 2e-39 135.3 0.0 3.7e-39 134.5 0.0 1.4 1 1 0 1 1 1 1 Sir2 family Pyridox_ox_2 PF12900.7 EWC46883.1 - 9.8e-34 116.4 0.0 1.3e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase ABC2_membrane PF01061.24 EWC46884.1 - 1.4e-85 286.0 57.2 2.2e-45 154.7 14.1 2.7 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 EWC46884.1 - 6.7e-33 114.1 0.0 1.3e-16 61.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EWC46884.1 - 4.3e-28 97.1 8.7 7.6e-26 89.9 0.0 3.2 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EWC46884.1 - 7.9e-08 32.8 0.1 2.7e-07 31.1 0.1 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_18 PF13238.6 EWC46884.1 - 2.2e-06 28.2 0.0 0.0087 16.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EWC46884.1 - 7.3e-06 26.0 0.1 0.00016 21.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EWC46884.1 - 1.7e-05 24.5 0.4 0.013 15.2 0.2 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EWC46884.1 - 2.7e-05 24.2 0.0 0.14 12.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EWC46884.1 - 3.1e-05 24.3 0.5 0.052 13.8 0.2 3.3 3 1 0 3 3 2 1 AAA domain AAA_16 PF13191.6 EWC46884.1 - 4.8e-05 23.8 0.0 0.0074 16.7 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EWC46884.1 - 0.00016 21.9 0.1 0.096 12.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EWC46884.1 - 0.00054 20.3 0.0 2.8 8.4 0.0 3.1 3 0 0 3 3 3 2 RNA helicase AAA_25 PF13481.6 EWC46884.1 - 0.00088 18.9 0.4 0.0078 15.8 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EWC46884.1 - 0.00089 19.5 0.1 0.0064 16.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EWC46884.1 - 0.0019 18.3 0.5 0.24 11.5 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EWC46884.1 - 0.002 17.9 0.1 0.38 10.4 0.1 2.4 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 EWC46884.1 - 0.0022 17.2 34.5 0.054 12.6 13.8 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_23 PF13476.6 EWC46884.1 - 0.0028 18.2 0.0 0.0079 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EWC46884.1 - 0.0053 16.7 0.4 0.18 11.7 0.2 2.4 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 EWC46884.1 - 0.01 16.3 0.1 1.8 9.0 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 EWC46884.1 - 0.022 14.6 0.0 0.073 13.0 0.0 1.8 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_24 PF13479.6 EWC46884.1 - 0.027 14.2 0.0 0.23 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EWC46884.1 - 0.029 13.7 0.2 6.8 6.0 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_17 PF13207.6 EWC46884.1 - 0.03 14.7 0.3 2.3 8.7 0.0 3.0 3 0 0 3 3 2 0 AAA domain DNAPolymera_Pol PF11590.8 EWC46884.1 - 0.044 13.7 0.5 0.14 12.0 0.5 1.8 1 0 0 1 1 1 0 DNA polymerase catalytic subunit Pol PhnG PF06754.12 EWC46884.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnG CAP_N PF01213.19 EWC46884.1 - 0.062 12.8 6.1 0.82 9.1 6.0 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Zeta_toxin PF06414.12 EWC46884.1 - 0.078 12.2 0.0 0.63 9.3 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin TsaE PF02367.17 EWC46884.1 - 0.085 12.9 1.1 0.18 11.8 0.5 1.9 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EWC46884.1 - 0.11 12.5 0.1 6.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain PRIMA1 PF16101.5 EWC46884.1 - 0.11 12.5 3.2 0.33 11.0 3.2 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ABC_ATPase PF09818.9 EWC46884.1 - 0.2 10.4 0.3 0.45 9.3 0.3 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class cobW PF02492.19 EWC46884.1 - 0.21 11.2 1.6 0.99 9.0 0.6 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain VIR_N PF15912.5 EWC46884.1 - 1.4 8.4 3.7 3 7.4 3.7 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal PTPA PF03095.15 EWC46885.1 - 3.3e-96 322.3 0.0 6.4e-86 288.5 0.0 2.0 1 1 1 2 2 2 2 Phosphotyrosyl phosphate activator (PTPA) protein RE_Eco29kI PF09517.10 EWC46886.1 - 0.02 14.5 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 Eco29kI restriction endonuclease PNP_UDP_1 PF01048.20 EWC46887.1 - 8.1e-38 130.0 0.1 1e-37 129.6 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PAP1 PF08601.10 EWC46888.1 - 6.9e-40 137.9 51.9 1.4e-37 130.3 0.3 3.7 1 1 3 4 4 4 3 Transcription factor PAP1 bZIP_1 PF00170.21 EWC46888.1 - 7.3e-10 38.8 14.7 1.3e-09 38.0 14.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 EWC46888.1 - 0.00046 20.0 8.8 0.0008 19.2 8.8 1.3 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 GAS PF13851.6 EWC46888.1 - 0.0044 16.4 10.9 0.0071 15.7 10.9 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF16 PF01519.16 EWC46888.1 - 0.0077 16.7 2.0 0.014 15.9 2.0 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF16 DUF812 PF05667.11 EWC46888.1 - 0.009 15.0 4.0 0.016 14.2 4.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TolA_bind_tri PF16331.5 EWC46888.1 - 0.017 15.2 3.1 0.034 14.2 3.1 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF4635 PF15466.6 EWC46888.1 - 0.029 13.9 0.2 0.052 13.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) dsrm PF00035.26 EWC46888.1 - 0.055 14.2 0.1 0.13 13.0 0.1 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding motif bZIP_2 PF07716.15 EWC46888.1 - 0.057 13.5 17.2 0.17 12.0 15.7 2.1 1 1 1 2 2 2 0 Basic region leucine zipper bZIP_Maf PF03131.17 EWC46888.1 - 0.079 13.5 12.6 0.14 12.6 12.6 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor XhlA PF10779.9 EWC46888.1 - 0.1 12.8 9.6 0.2 11.9 9.6 1.4 1 0 0 1 1 1 0 Haemolysin XhlA DUF5320 PF17253.2 EWC46888.1 - 0.1 13.6 0.9 0.22 12.6 0.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5320) DivIC PF04977.15 EWC46888.1 - 0.12 12.2 7.8 0.24 11.2 7.8 1.4 1 0 0 1 1 1 0 Septum formation initiator FlaC_arch PF05377.11 EWC46888.1 - 0.15 12.5 4.5 0.33 11.4 4.5 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) PSI_PsaF PF02507.15 EWC46888.1 - 0.18 11.6 0.7 0.46 10.3 0.7 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III TMCO5 PF14992.6 EWC46888.1 - 0.2 11.2 4.6 0.32 10.5 4.6 1.2 1 0 0 1 1 1 0 TMCO5 family GrpE PF01025.19 EWC46888.1 - 0.26 10.9 6.9 0.47 10.1 6.9 1.3 1 0 0 1 1 1 0 GrpE Atg14 PF10186.9 EWC46888.1 - 0.63 9.1 6.9 1 8.4 6.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 EWC46888.1 - 0.77 7.6 2.6 1.1 7.1 2.6 1.1 1 0 0 1 1 1 0 Prominin V_ATPase_I PF01496.19 EWC46888.1 - 0.92 7.3 2.5 1.3 6.9 2.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 EWC46888.1 - 1.4 8.1 3.2 2.1 7.5 3.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein UPF0242 PF06785.11 EWC46888.1 - 1.6 8.8 8.2 2.6 8.1 8.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Phlebovirus_NSM PF07246.11 EWC46888.1 - 2.9 7.2 6.3 4.4 6.6 6.3 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Fzo_mitofusin PF04799.13 EWC46888.1 - 5.2 6.6 5.2 8.1 6.0 5.2 1.2 1 0 0 1 1 1 0 fzo-like conserved region DUF4407 PF14362.6 EWC46888.1 - 7.2 5.9 5.4 11 5.2 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SMN PF06003.12 EWC46889.1 - 1e-07 31.5 0.1 1e-07 31.5 0.1 1.8 1 1 0 2 2 2 1 Survival motor neuron protein (SMN) Tudor_3 PF18115.1 EWC46889.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Tudor_2 PF18104.1 EWC46889.1 - 0.074 12.7 0.1 0.17 11.6 0.1 1.6 1 1 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain DUF4537 PF15057.6 EWC46889.1 - 0.076 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Fis1_TPR_C PF14853.6 EWC46889.1 - 0.085 12.9 0.4 0.15 12.2 0.4 1.3 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat DEAD PF00270.29 EWC46890.1 - 1.8e-40 138.6 0.1 3.7e-40 137.5 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC46890.1 - 3.4e-23 82.1 0.3 2.1e-22 79.5 0.2 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC46890.1 - 0.00038 20.5 0.0 0.0011 19.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EWC46890.1 - 0.027 14.7 0.1 0.92 9.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain RCC1 PF00415.18 EWC46891.1 - 2.9e-25 88.6 0.5 1.1e-09 38.8 0.2 5.4 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EWC46891.1 - 8.3e-12 45.3 0.0 1.7e-09 37.9 0.0 2.7 2 0 0 2 2 2 1 BTB/POZ domain Ank_4 PF13637.6 EWC46891.1 - 2.3e-09 37.6 0.0 5.8e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) RCC1_2 PF13540.6 EWC46891.1 - 2.3e-07 30.4 0.4 2.3e-07 30.4 0.4 3.7 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 EWC46891.1 - 1.3e-06 28.9 0.0 3.6e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EWC46891.1 - 1.1e-05 25.4 0.0 0.018 15.6 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EWC46891.1 - 0.00017 21.8 0.0 0.26 11.7 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EWC46891.1 - 0.062 13.8 0.6 1.3 9.6 0.1 2.8 3 0 0 3 3 3 0 Ankyrin repeat GRP PF07172.11 EWC46891.1 - 2.8 8.7 15.7 6.6 7.5 15.7 1.6 1 0 0 1 1 1 0 Glycine rich protein family NAD_binding_10 PF13460.6 EWC46892.1 - 3.5e-08 33.6 0.0 1.1e-07 31.9 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EWC46892.1 - 7.7e-08 32.1 0.0 2.5e-06 27.1 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EWC46892.1 - 0.00024 20.7 0.0 0.064 12.8 0.1 2.2 2 0 0 2 2 2 2 NmrA-like family HIM1 PF08732.10 EWC46892.1 - 0.00035 20.1 0.0 0.00078 19.0 0.0 1.5 1 1 0 1 1 1 1 HIM1 Semialdhyde_dh PF01118.24 EWC46892.1 - 0.003 18.0 0.0 0.014 15.8 0.0 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EWC46892.1 - 0.0048 16.1 0.0 0.19 10.8 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein DUF1471 PF07338.13 EWC46892.1 - 0.022 14.7 0.2 0.055 13.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1471) DUF2433 PF10360.9 EWC46893.1 - 8.4e-49 164.8 0.0 1.3e-48 164.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos PF00149.28 EWC46893.1 - 0.005 17.4 0.0 0.0091 16.5 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EWC46893.1 - 0.025 14.8 0.0 0.16 12.1 0.0 2.3 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Patched PF02460.18 EWC46894.1 - 4.9e-81 273.0 7.7 4.5e-50 170.6 0.0 2.1 2 0 0 2 2 2 2 Patched family NPC1_N PF16414.5 EWC46894.1 - 8.3e-79 264.6 2.4 1.3e-78 264.0 2.4 1.3 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 EWC46894.1 - 4e-54 182.6 4.1 4e-54 182.6 4.1 3.3 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EWC46894.1 - 0.00018 20.6 25.9 0.00032 19.7 7.8 2.4 2 0 0 2 2 2 2 MMPL family Folate_rec PF03024.14 EWC46894.1 - 0.0035 17.2 0.9 0.0065 16.4 0.9 1.4 1 0 0 1 1 1 1 Folate receptor family ACR_tran PF00873.19 EWC46894.1 - 0.28 8.8 11.4 0.61 7.7 11.4 1.5 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Solute_trans_a PF03619.16 EWC46895.1 - 7.9e-81 271.5 20.7 1e-80 271.1 20.7 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha PrgI PF12666.7 EWC46895.1 - 0.02 15.6 0.9 0.02 15.6 0.9 3.5 3 2 0 3 3 3 0 PrgI family protein NrsF PF06532.11 EWC46895.1 - 0.44 10.2 5.1 3.4 7.3 0.0 2.8 2 1 1 3 3 3 0 Negative regulator of sigma F ECH_1 PF00378.20 EWC46896.1 - 1.3e-38 132.7 0.1 2e-38 132.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EWC46896.1 - 8.8e-27 94.5 0.2 7.8e-24 84.8 0.3 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Kelch_3 PF13415.6 EWC46897.1 - 7.3e-07 29.3 0.5 0.24 11.7 0.0 3.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EWC46897.1 - 2.9e-05 23.6 0.1 0.47 10.1 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EWC46897.1 - 0.002 18.1 4.4 0.86 9.7 0.4 3.9 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EWC46897.1 - 0.0062 16.8 4.8 17 5.9 0.1 4.5 4 0 0 4 4 4 1 Kelch motif DUF3328 PF11807.8 EWC46898.1 - 3.6e-52 177.3 0.0 5.1e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) HEAT_EZ PF13513.6 EWC46899.1 - 1.6e-23 82.8 6.6 1.5e-08 35.0 2.0 8.9 7 1 2 9 9 9 4 HEAT-like repeat HEAT_2 PF13646.6 EWC46899.1 - 9.3e-19 67.6 8.3 4.8e-07 30.1 0.4 7.9 5 2 2 7 7 7 3 HEAT repeats HEAT PF02985.22 EWC46899.1 - 1.1e-14 53.3 14.3 0.00043 20.3 0.1 11.2 13 0 0 13 13 10 2 HEAT repeat Arm PF00514.23 EWC46899.1 - 5.2e-12 45.4 5.8 0.4 10.8 0.1 7.3 7 0 0 7 7 6 3 Armadillo/beta-catenin-like repeat IFRD PF05004.13 EWC46899.1 - 1.3e-11 44.2 0.3 2.6e-05 23.5 0.0 4.2 2 1 1 3 3 3 3 Interferon-related developmental regulator (IFRD) UME PF08064.13 EWC46899.1 - 1.2e-10 41.1 0.1 0.042 13.8 0.0 5.3 5 1 1 6 6 5 4 UME (NUC010) domain IBN_N PF03810.19 EWC46899.1 - 5.9e-09 35.7 4.3 3.4e-07 30.1 0.3 4.0 4 0 0 4 4 3 1 Importin-beta N-terminal domain Adaptin_N PF01602.20 EWC46899.1 - 1.7e-08 33.5 0.6 2.7e-06 26.2 0.0 3.9 3 1 0 5 5 5 1 Adaptin N terminal region MMS19_C PF12460.8 EWC46899.1 - 2.8e-08 33.3 2.2 0.02 14.0 0.0 5.7 5 2 2 7 7 7 2 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 EWC46899.1 - 1.1e-07 32.1 4.0 0.036 14.1 0.0 5.4 5 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EWC46899.1 - 1.4e-07 32.1 0.1 0.006 17.2 0.0 5.6 4 1 2 6 6 6 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EWC46899.1 - 3e-07 30.2 0.1 1.1 8.7 0.0 5.8 4 2 2 6 6 6 1 CLASP N terminal MMS19_N PF14500.6 EWC46899.1 - 4.6e-06 26.4 1.6 0.14 11.8 0.0 5.6 5 2 0 6 6 6 1 Dos2-interacting transcription regulator of RNA-Pol-II ParcG PF10274.9 EWC46899.1 - 5.6e-06 26.6 0.0 0.0098 16.0 0.0 3.0 3 0 0 3 3 2 2 Parkin co-regulated protein Ecm29 PF13001.7 EWC46899.1 - 9.4e-06 24.6 0.0 0.98 8.0 0.0 4.4 4 1 0 4 4 4 1 Proteasome stabiliser RTP1_C1 PF10363.9 EWC46899.1 - 0.00041 20.5 0.2 0.067 13.4 0.0 4.0 3 1 0 3 3 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 EWC46899.1 - 0.0029 18.1 8.4 0.36 11.6 0.2 6.5 8 0 0 8 8 5 1 PBS lyase HEAT-like repeat RIX1 PF08167.12 EWC46899.1 - 0.0057 16.4 0.4 1.8 8.2 0.0 4.9 4 1 2 6 6 6 1 rRNA processing/ribosome biogenesis Cohesin_HEAT PF12765.7 EWC46899.1 - 0.0065 16.7 0.6 0.07 13.5 0.1 2.9 3 0 0 3 3 2 1 HEAT repeat associated with sister chromatid cohesion Ipi1_N PF12333.8 EWC46899.1 - 0.01 16.4 0.0 0.29 11.7 0.0 3.5 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation DUF3437 PF11919.8 EWC46899.1 - 0.012 15.5 1.6 15 5.6 0.1 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3437) DUF4042 PF13251.6 EWC46899.1 - 0.012 15.3 1.4 0.36 10.5 0.1 4.1 4 1 0 4 4 3 0 Domain of unknown function (DUF4042) DUF3385 PF11865.8 EWC46899.1 - 0.016 15.2 6.8 3.9 7.4 0.0 6.3 6 2 3 9 9 7 0 Domain of unknown function (DUF3385) NUC173 PF08161.12 EWC46899.1 - 0.026 14.2 0.4 29 4.3 0.0 4.9 4 2 1 6 6 5 0 NUC173 domain DUF2732 PF10809.8 EWC46899.1 - 0.085 12.7 0.1 0.28 11.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2732) RasGEF_N_2 PF14663.6 EWC46899.1 - 0.18 12.3 2.4 4.3 7.8 0.1 4.0 5 0 0 5 5 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain API5 PF05918.11 EWC46899.1 - 0.22 10.3 2.4 1.1 8.0 0.2 2.9 3 0 0 3 3 3 0 Apoptosis inhibitory protein 5 (API5) Gcn1_N PF12074.8 EWC46899.1 - 0.34 10.2 2.9 11 5.2 0.0 4.0 4 1 0 4 4 4 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal DUF4235 PF14019.6 EWC46899.1 - 0.52 10.4 2.2 0.83 9.8 0.1 2.5 3 0 0 3 3 1 0 Protein of unknown function (DUF4235) V-ATPase_H_C PF11698.8 EWC46899.1 - 1.6 8.9 3.7 80 3.4 0.0 4.7 6 1 0 6 6 4 0 V-ATPase subunit H SNF2_N PF00176.23 EWC46900.1 - 3.5e-61 206.9 1.4 8.6e-56 189.1 1.0 2.8 2 1 1 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC46900.1 - 2.4e-16 60.0 0.0 5.8e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC46900.1 - 0.00042 20.4 0.1 0.002 18.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PHY PF00360.20 EWC46901.1 - 4.1e-28 97.9 0.0 7.8e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 EWC46901.1 - 2.5e-15 57.0 0.1 5.2e-15 55.9 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EWC46901.1 - 6.6e-15 55.3 0.0 1.9e-14 53.8 0.0 1.8 1 1 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EWC46901.1 - 1.2e-13 50.8 0.9 2.9e-13 49.6 0.9 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 EWC46901.1 - 9e-11 42.5 0.0 4.2e-10 40.4 0.0 2.2 2 0 0 2 2 2 1 GAF domain PAS_2 PF08446.11 EWC46901.1 - 4.2e-06 27.4 0.0 1.4e-05 25.7 0.0 1.9 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 EWC46901.1 - 0.13 12.0 0.2 0.28 11.0 0.2 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LAMTOR PF15454.6 EWC46902.1 - 2.7e-11 43.9 0.4 4.4e-11 43.2 0.4 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator CCM2_C PF16545.5 EWC46904.1 - 1 9.9 3.8 0.87 10.2 0.6 2.6 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology Ribosomal_L33 PF00471.20 EWC46905.1 - 0.013 16.0 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L33 HPP PF04982.13 EWC46907.1 - 8.1e-40 135.8 5.0 1.2e-39 135.2 3.3 1.8 2 0 0 2 2 2 1 HPP family DUF3742 PF12553.8 EWC46907.1 - 0.45 10.6 1.9 0.75 9.9 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) Med13_C PF06333.12 EWC46908.1 - 1.2e-78 264.8 0.0 3.8e-78 263.1 0.0 1.9 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EWC46908.1 - 2.7e-27 96.0 5.9 4.3e-26 92.0 5.9 2.3 1 1 0 1 1 1 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EWC46908.1 - 9.7e-13 48.5 4.8 7.2e-08 32.5 0.6 2.8 2 1 1 3 3 3 2 MID domain of medPIWI CD99L2 PF12301.8 EWC46908.1 - 6.7 7.0 6.7 0.68 10.2 0.8 2.2 2 0 0 2 2 2 0 CD99 antigen like protein 2 Tyrosinase PF00264.20 EWC46909.1 - 3.1e-44 151.9 1.3 3.1e-44 151.9 1.3 2.1 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EWC46909.1 - 1.1e-08 35.7 0.0 1.8e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Tyosinase C-terminal domain zf-Nse PF11789.8 EWC46910.1 - 8.5e-16 57.5 0.4 1.5e-15 56.8 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EWC46910.1 - 0.00023 21.1 0.1 0.00044 20.2 0.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 EWC46910.1 - 0.0021 17.5 10.5 0.0085 15.5 10.5 1.9 1 1 0 1 1 1 1 Rtf2 RING-finger zf-MIZ PF02891.20 EWC46910.1 - 0.0064 16.2 0.2 0.011 15.5 0.2 1.3 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 EWC46910.1 - 0.0067 16.2 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MAJIN PF15077.6 EWC46910.1 - 2.4 7.9 5.0 4.9 6.9 5.0 1.5 1 0 0 1 1 1 0 Membrane-anchored junction protein Plasmodium_Vir PF05795.11 EWC46910.1 - 3.3 7.0 6.2 5.8 6.2 6.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PEX11 PF05648.14 EWC46911.1 - 7.6e-68 228.3 0.5 8.5e-68 228.1 0.5 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Ank_2 PF12796.7 EWC46912.1 - 1.2e-17 64.3 0.0 7.6e-09 36.0 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EWC46912.1 - 6.6e-12 44.5 0.0 0.049 14.2 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EWC46912.1 - 3.7e-11 42.9 0.2 0.0031 17.9 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EWC46912.1 - 2.6e-10 40.3 0.2 0.0053 17.0 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EWC46912.1 - 4.4e-10 39.9 0.0 9.3e-05 22.9 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) RuvC PF02075.17 EWC46912.1 - 6.1 6.7 9.8 0.77 9.6 3.0 2.7 2 1 1 3 3 3 0 Crossover junction endodeoxyribonuclease RuvC Aminotran_1_2 PF00155.21 EWC46913.1 - 4.6e-38 131.3 0.0 1.7e-37 129.5 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Amnionless PF14828.6 EWC46914.1 - 0.029 13.2 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 Amnionless CD34_antigen PF06365.12 EWC46914.1 - 0.047 13.3 0.1 0.069 12.7 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF2070 PF09843.9 EWC46914.1 - 0.063 11.6 0.1 0.079 11.2 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MGC-24 PF05283.11 EWC46914.1 - 0.12 12.9 0.4 0.21 12.0 0.4 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FixQ PF05545.11 EWC46914.1 - 0.12 12.3 0.1 0.28 11.2 0.1 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ NUC153 PF08159.12 EWC46915.1 - 2.4e-11 43.2 0.2 4e-11 42.5 0.2 1.4 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EWC46915.1 - 8.9e-05 23.2 0.0 0.087 13.7 0.0 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC46915.1 - 0.011 16.0 0.0 0.029 14.7 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Pox_MCEL PF03291.16 EWC46916.1 - 2e-70 237.6 0.0 3.1e-70 236.9 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.12 EWC46916.1 - 1e-08 35.8 0.0 2.9e-08 34.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC46916.1 - 2.6e-07 31.2 0.0 0.0031 18.2 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EWC46916.1 - 3.2e-05 23.8 0.0 0.00034 20.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC46916.1 - 0.00084 19.2 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC46916.1 - 0.0025 18.4 0.0 4.2 8.1 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EWC46916.1 - 0.012 14.8 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Raftlin PF15250.6 EWC46916.1 - 4.1 6.0 5.2 4 6.1 0.0 2.3 2 0 0 2 2 2 0 Raftlin Cep57_CLD_2 PF14197.6 EWC46916.1 - 5.4 7.2 8.1 27 4.9 0.2 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 RPN7 PF10602.9 EWC46917.1 - 1.3e-56 191.0 2.4 2.2e-56 190.3 2.4 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EWC46917.1 - 9.1e-13 48.6 0.0 1.4e-11 44.8 0.0 2.4 2 0 0 2 2 2 1 PCI domain An_peroxidase PF03098.15 EWC46918.1 - 1.8e-40 139.0 0.0 4.5e-29 101.4 0.0 3.5 1 1 1 2 2 2 2 Animal haem peroxidase PLDc PF00614.22 EWC46919.1 - 3.8e-16 58.5 1.8 2.7e-07 30.5 0.1 2.9 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EWC46919.1 - 5.9e-15 55.3 5.6 7.4e-07 29.1 0.1 3.8 4 0 0 4 4 4 3 PLD-like domain Mito_carr PF00153.27 EWC46920.1 - 2.5e-50 168.3 2.8 1.7e-16 59.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2461 PF09365.10 EWC46920.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) Peptidase_C15 PF01470.17 EWC46921.1 - 0.00079 19.7 0.1 0.39 10.9 0.0 3.0 3 0 0 3 3 3 2 Pyroglutamyl peptidase UPF0730 PF15827.5 EWC46921.1 - 0.17 11.6 0.1 0.44 10.3 0.1 1.6 1 0 0 1 1 1 0 UPF0730 unknown protein family MOSC PF03473.17 EWC46922.1 - 4.2e-29 101.2 0.0 6e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EWC46922.1 - 2.8e-12 46.5 0.0 1.3e-09 37.9 0.0 2.6 3 0 0 3 3 3 2 MOSC N-terminal beta barrel domain Peptidase_C14 PF00656.22 EWC46923.1 - 2e-60 204.8 0.0 2.6e-60 204.5 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Swi5 PF07061.11 EWC46923.1 - 0.025 14.7 0.1 0.061 13.4 0.0 1.6 2 0 0 2 2 2 0 Swi5 Zn_clus PF00172.18 EWC46925.1 - 4.4e-09 36.3 8.0 4.4e-09 36.3 8.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SET PF00856.28 EWC46925.1 - 0.067 13.6 0.0 1.2 9.5 0.0 2.4 1 1 0 1 1 1 0 SET domain DUF1983 PF09327.11 EWC46926.1 - 0.038 14.1 0.2 0.074 13.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1983) DUF5338 PF17273.2 EWC46926.1 - 0.21 11.7 0.1 0.3 11.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5338) SHMT PF00464.19 EWC46927.1 - 1.3e-196 653.0 0.0 1.5e-196 652.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 EWC46927.1 - 0.02 14.2 0.7 0.078 12.3 0.7 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EWC46927.1 - 0.077 12.3 0.0 0.13 11.5 0.0 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase Mg_trans_NIPA PF05653.14 EWC46928.1 - 7e-92 307.7 23.9 9.6e-92 307.2 23.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EWC46928.1 - 3.4e-06 27.3 5.9 3.4e-06 27.3 5.9 3.6 3 1 0 3 3 3 1 EamA-like transporter family Tmemb_161AB PF10268.9 EWC46928.1 - 0.018 13.7 0.2 0.034 12.8 0.2 1.4 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB DUF805 PF05656.14 EWC46928.1 - 0.07 13.6 12.0 1.8 9.0 3.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Ac76 PF05814.11 EWC46928.1 - 0.48 10.5 2.3 0.65 10.1 0.3 2.2 2 0 0 2 2 2 0 Orf76 (Ac76) DUF1129 PF06570.11 EWC46928.1 - 1.1 8.7 9.9 0.46 9.9 3.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Mcp5_PH PF12814.7 EWC46929.1 - 1.1e-43 148.2 0.0 2e-43 147.4 0.0 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Fez1 PF06818.15 EWC46929.1 - 0.0006 20.3 13.8 0.0006 20.3 13.8 3.4 1 1 2 3 3 3 1 Fez1 DUF5136 PF17199.4 EWC46929.1 - 0.00069 19.3 0.3 0.0025 17.5 0.3 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF5136) Kinesin_assoc PF16183.5 EWC46929.1 - 3.1 7.9 6.2 13 5.9 4.7 2.8 2 1 1 3 3 3 0 Kinesin-associated Ras PF00071.22 EWC46930.1 - 2.4e-51 173.5 0.3 2e-50 170.5 0.3 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EWC46930.1 - 1.4e-18 67.2 0.0 6.7e-17 61.8 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC46930.1 - 0.00031 20.2 0.1 0.0029 17.1 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 EWC46930.1 - 0.0035 16.8 0.0 0.94 8.9 0.0 2.1 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EWC46930.1 - 0.012 15.5 0.1 4.8 7.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Septin PF00735.18 EWC46930.1 - 0.055 12.8 0.4 0.15 11.3 0.0 1.8 3 0 0 3 3 3 0 Septin AAA_25 PF13481.6 EWC46930.1 - 0.11 12.0 0.1 0.25 10.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EWC46930.1 - 0.2 11.2 0.4 2.7 7.5 0.0 2.3 2 1 1 3 3 3 0 Ferrous iron transport protein B CH PF00307.31 EWC46931.1 - 4.1e-67 223.2 0.1 2.8e-17 62.8 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EWC46931.1 - 0.00016 22.1 0.4 0.00039 20.8 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain pair CAMSAP_CH PF11971.8 EWC46931.1 - 0.078 12.8 0.0 2.9 7.8 0.0 2.8 3 0 0 3 3 3 0 CAMSAP CH domain SAICAR_synt PF01259.18 EWC46934.1 - 1.5e-104 349.1 0.0 1.7e-104 348.9 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase ABC_tran PF00005.27 EWC46935.1 - 9.3e-35 120.1 0.0 1.7e-34 119.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EWC46935.1 - 2e-21 76.9 12.9 2e-21 76.9 12.9 2.1 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EWC46935.1 - 0.00022 20.7 0.1 0.011 15.2 0.0 2.5 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EWC46935.1 - 0.00034 20.9 0.0 0.0018 18.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EWC46935.1 - 0.0053 16.7 0.0 0.052 13.4 0.0 2.4 3 0 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EWC46935.1 - 0.0085 16.5 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EWC46935.1 - 0.016 15.0 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 EWC46935.1 - 0.017 14.9 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase Zeta_toxin PF06414.12 EWC46935.1 - 0.019 14.2 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 EWC46935.1 - 0.025 14.7 0.0 0.077 13.1 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.6 EWC46935.1 - 0.036 13.8 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 EWC46935.1 - 0.051 13.7 0.1 0.096 12.8 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_29 PF13555.6 EWC46935.1 - 0.055 13.2 0.1 0.17 11.6 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EWC46935.1 - 0.069 13.6 0.0 0.21 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Glyco_transf_34 PF05637.12 EWC46936.1 - 6.1e-31 108.0 0.0 8.3e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family zf-C2HE PF16278.5 EWC46936.1 - 0.11 13.0 0.1 0.25 11.8 0.1 1.6 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger DRMBL PF07522.14 EWC46937.1 - 1.2e-34 118.8 0.0 2.2e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EWC46937.1 - 7.1e-07 28.9 0.0 1.4e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain LSM PF01423.22 EWC46938.1 - 6.9e-18 64.1 0.3 8.9e-18 63.8 0.3 1.2 1 0 0 1 1 1 1 LSM domain Ribosomal_L37 PF08561.10 EWC46939.1 - 2.8e-34 118.2 0.5 4e-34 117.7 0.5 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 RRM_1 PF00076.22 EWC46940.1 - 1.8e-41 139.8 0.0 9.9e-20 70.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EWC46940.1 - 0.0069 16.5 0.0 6.5 6.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EWC46940.1 - 0.014 15.3 0.1 6.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EWC46940.1 - 0.028 14.3 0.1 0.96 9.4 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif SET_assoc PF11767.8 EWC46940.1 - 0.043 13.5 0.0 0.32 10.7 0.0 2.1 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Pox_A22 PF04848.13 EWC46940.1 - 0.072 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A22 protein Surp PF01805.20 EWC46942.1 - 6.7e-12 45.2 0.0 1.4e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Surp module PTP_tm PF18861.1 EWC46943.1 - 0.2 11.6 0.0 0.31 11.0 0.0 1.2 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Glyco_hyd_65N_2 PF14498.6 EWC46944.1 - 3.6e-61 207.0 0.0 5e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain DUF4078 PF13300.6 EWC46946.1 - 2.3e-21 75.9 22.7 2.3e-21 75.9 22.7 3.8 3 2 1 4 4 4 1 Domain of unknown function (DUF4078) CENP-H PF05837.12 EWC46947.1 - 4.8e-25 88.1 1.9 4.8e-25 88.1 1.9 1.8 2 1 0 2 2 2 1 Centromere protein H (CENP-H) UPF0242 PF06785.11 EWC46947.1 - 0.024 14.7 0.4 0.024 14.7 0.4 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 EWC46947.1 - 0.062 13.5 10.9 0.024 14.9 7.2 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SlyX PF04102.12 EWC46947.1 - 1.2 9.7 8.4 12 6.6 1.3 3.2 2 1 1 3 3 3 0 SlyX DUF2890 PF11081.8 EWC46948.1 - 0.089 12.9 0.2 0.097 12.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Ish1 PF10281.9 EWC46949.1 - 2.1e-90 296.7 28.1 3.9e-14 52.6 0.4 8.3 8 0 0 8 8 8 7 Putative stress-responsive nuclear envelope protein HeH PF12949.7 EWC46949.1 - 2e-13 49.8 0.0 0.00047 19.8 0.1 6.8 7 0 0 7 7 7 2 HeH/LEM domain SAP PF02037.27 EWC46949.1 - 1.1e-08 34.6 0.0 0.4 10.5 0.0 6.6 6 1 0 6 6 6 2 SAP domain Slx4 PF09494.10 EWC46949.1 - 1.3e-07 31.5 2.6 0.16 12.0 0.0 6.3 7 0 0 7 7 7 1 Slx4 endonuclease DUF4224 PF13986.6 EWC46949.1 - 5.1e-05 23.1 0.1 10 6.1 0.0 5.3 5 0 0 5 5 5 1 Domain of unknown function (DUF4224) Endonuc-dimeris PF09124.10 EWC46949.1 - 0.0011 19.1 0.1 19 5.5 0.0 4.6 4 0 0 4 4 4 0 T4 recombination endonuclease VII, dimerisation Thymopoietin PF08198.11 EWC46949.1 - 0.013 15.1 0.1 6.2 6.5 0.0 3.4 3 0 0 3 3 3 0 Thymopoietin protein DUF883 PF05957.13 EWC46949.1 - 0.051 14.2 11.7 0.71 10.5 0.8 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) SLATT_4 PF18186.1 EWC46949.1 - 0.052 13.2 1.0 0.19 11.3 0.6 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 SAP30_Sin3_bdg PF13867.6 EWC46949.1 - 0.12 12.7 2.7 24 5.3 0.1 3.8 4 0 0 4 4 3 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DNA_meth_N PF18284.1 EWC46949.1 - 0.12 12.2 5.2 7.8 6.5 0.1 4.1 4 0 0 4 4 4 0 DNA methylase N-terminal domain TusA PF01206.17 EWC46949.1 - 0.12 12.2 0.1 56 3.7 0.0 3.8 4 0 0 4 4 4 0 Sulfurtransferase TusA LEM PF03020.15 EWC46949.1 - 0.18 11.4 0.0 6.9 6.3 0.0 3.0 3 0 0 3 3 3 0 LEM domain DUF4518 PF15008.6 EWC46949.1 - 0.27 10.4 7.6 13 4.9 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4518) HMG_CoA_synt_C PF08540.10 EWC46950.1 - 4e-103 344.9 0.4 5.4e-103 344.4 0.4 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EWC46950.1 - 1.5e-96 321.2 0.3 2.2e-96 320.7 0.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal hSac2 PF12456.8 EWC46952.1 - 0.061 13.0 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Inositol phosphatase HR1 PF02185.16 EWC46952.1 - 3.5 7.8 19.3 0.52 10.5 0.6 3.9 3 0 0 3 3 3 0 Hr1 repeat Syntaxin_2 PF14523.6 EWC46952.1 - 6 7.3 20.7 0.057 13.8 7.9 3.2 2 1 1 3 3 3 0 Syntaxin-like protein Nup54 PF13874.6 EWC46952.1 - 9.9 6.3 19.9 1.2 9.3 10.9 2.7 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 RRM_1 PF00076.22 EWC46953.1 - 3.5e-16 58.8 0.0 4.9e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Homeobox_KN PF05920.11 EWC46954.1 - 2.7e-21 75.2 0.5 2.6e-20 72.0 0.4 2.5 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EWC46954.1 - 7.9e-07 28.8 2.2 1.4e-06 28.0 0.4 2.3 2 0 0 2 2 2 1 Homeodomain NUDE_C PF04880.13 EWC46955.1 - 7.5e-31 108.0 6.0 7.5e-31 108.0 6.0 3.6 3 0 0 3 3 3 1 NUDE protein, C-terminal conserved region MAD PF05557.13 EWC46955.1 - 0.0051 15.2 28.3 0.0071 14.8 28.3 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein PSII_Pbs27 PF13326.6 EWC46955.1 - 0.027 14.8 5.1 0.055 13.8 4.6 1.8 1 1 0 1 1 1 0 Photosystem II Pbs27 Cytochrom_B559a PF00284.20 EWC46955.1 - 0.15 11.8 0.6 1.4 8.8 0.0 2.6 2 0 0 2 2 2 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit DUF1515 PF07439.11 EWC46955.1 - 1.9 8.5 5.9 2.5 8.2 1.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) CENP-F_leu_zip PF10473.9 EWC46955.1 - 4.7 7.2 36.9 0.07 13.2 19.8 2.8 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EWC46955.1 - 4.9 7.2 36.1 1.6 8.8 20.4 3.1 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein YjbH PF06082.11 EWC46955.1 - 5.2 5.8 9.8 6.8 5.4 9.8 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Tropomyosin_1 PF12718.7 EWC46955.1 - 8.4 6.5 35.0 5.2 7.2 21.7 3.7 2 1 1 3 3 3 0 Tropomyosin like ZapB PF06005.12 EWC46955.1 - 8.4 6.9 39.2 0.16 12.4 8.8 4.5 2 1 2 4 4 4 0 Cell division protein ZapB Glyco_tran_WecB PF03808.13 EWC46956.1 - 0.0057 16.6 1.3 0.047 13.7 0.2 2.7 1 1 2 3 3 3 1 Glycosyl transferase WecB/TagA/CpsF family FTR_C PF02741.15 EWC46956.1 - 0.0097 15.9 5.5 0.028 14.4 4.7 2.2 2 0 0 2 2 2 1 FTR, proximal lobe Apolipoprotein PF01442.18 EWC46956.1 - 0.18 11.7 9.0 1.4 8.7 7.5 3.1 2 1 1 3 3 3 0 Apolipoprotein A1/A4/E domain DUF4140 PF13600.6 EWC46956.1 - 0.54 10.7 5.6 0.26 11.7 1.3 2.6 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF3405 PF11885.8 EWC46957.1 - 0.0029 16.3 0.3 0.0057 15.3 0.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3405) DUF3405 PF11885.8 EWC46958.1 - 1.9e-11 43.3 0.0 1.8e-06 26.9 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3405) Acyltransferase PF01553.21 EWC46959.1 - 1.1e-31 109.2 0.0 1.6e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase CoA_binding_3 PF13727.6 EWC46959.1 - 3 7.9 5.2 1.1 9.2 2.8 1.6 2 0 0 2 2 2 0 CoA-binding domain ACPS PF01648.20 EWC46960.1 - 1.8e-07 31.3 0.0 3.3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily FAD_binding_6 PF00970.24 EWC46961.1 - 6.6e-33 113.0 0.0 9.8e-33 112.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EWC46961.1 - 1.4e-28 99.7 0.0 2e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EWC46961.1 - 1.7e-06 28.3 0.0 0.00013 22.1 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain DUF2794 PF10984.8 EWC46961.1 - 0.16 12.2 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2794) DUF3605 PF12239.8 EWC46962.1 - 5.7e-58 195.6 0.1 7e-58 195.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Tautomerase PF01361.21 EWC46962.1 - 0.097 12.6 0.0 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 Tautomerase enzyme CENP-T_C PF15511.6 EWC46963.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EWC46963.1 - 2.4e-05 24.7 0.1 2.8e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EWC46963.1 - 7.2e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EWC46963.1 - 0.0002 21.6 0.1 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EWC46963.1 - 0.0004 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EWC46963.1 - 0.0085 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EWC46963.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EWC46963.1 - 0.052 13.3 0.2 0.064 13.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 EWC46963.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region TMEM208_SND2 PF05620.11 EWC46964.1 - 3.7e-50 170.0 0.3 4.2e-50 169.8 0.3 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 TRIQK PF15168.6 EWC46964.1 - 0.44 10.5 4.0 0.38 10.7 0.2 2.4 2 1 0 2 2 2 0 Triple QxxK/R motif-containing protein family ACC_central PF08326.12 EWC46965.1 - 1.5e-271 902.9 0.0 1.8e-271 902.6 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EWC46965.1 - 7.3e-189 628.5 0.0 9.5e-189 628.1 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EWC46965.1 - 9e-52 175.6 0.0 1.6e-51 174.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EWC46965.1 - 2.5e-28 98.8 0.1 4.7e-28 97.9 0.1 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EWC46965.1 - 2.3e-19 69.5 0.0 2.2e-18 66.3 0.0 2.6 3 0 0 3 3 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EWC46965.1 - 7e-17 61.0 0.5 1.8e-16 59.7 0.5 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 EWC46965.1 - 0.00029 20.9 0.0 0.0013 18.8 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EWC46965.1 - 0.0012 18.7 0.1 0.0045 16.8 0.0 2.0 2 0 0 2 2 2 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EWC46965.1 - 0.0046 16.5 0.2 0.032 13.8 0.0 2.5 3 0 0 3 3 3 1 D-ala D-ala ligase C-terminus RnfC_N PF13375.6 EWC46965.1 - 0.03 14.3 0.0 0.094 12.7 0.0 1.8 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATPgrasp_Ter PF15632.6 EWC46965.1 - 0.043 13.6 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon GxGYxYP_N PF16216.5 EWC46965.1 - 0.044 14.0 0.0 0.09 12.9 0.0 1.5 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal DUF1376 PF07120.11 EWC46965.1 - 0.14 12.5 0.6 1.1 9.7 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1376) RIO1 PF01163.22 EWC46966.1 - 1.6e-65 220.2 0.0 1.6e-65 220.2 0.0 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EWC46966.1 - 0.021 14.7 0.7 2.8 7.8 0.0 2.9 3 0 0 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EWC46966.1 - 0.026 13.9 0.4 4.2 6.7 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3464 PF11947.8 EWC46966.1 - 4.7 6.9 11.9 0.1 12.3 3.4 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 SMC_N PF02463.19 EWC46967.1 - 1.2e-63 214.4 32.4 5.1e-63 212.5 32.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EWC46967.1 - 2.9e-30 105.0 0.0 1.7e-29 102.5 0.0 2.4 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EWC46967.1 - 5e-16 59.4 18.2 1.2e-11 45.1 0.2 4.3 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EWC46967.1 - 5.3e-13 49.4 67.3 5.5e-11 42.8 19.9 4.5 2 2 1 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 EWC46967.1 - 1.3e-05 25.8 53.3 1.3e-05 25.8 53.3 6.9 3 3 1 4 4 1 1 AAA domain Filament PF00038.21 EWC46967.1 - 0.0012 18.5 34.4 0.0012 18.5 34.4 4.9 2 2 2 4 4 2 2 Intermediate filament protein CALCOCO1 PF07888.11 EWC46967.1 - 0.0027 16.7 22.2 0.0027 16.7 22.2 5.2 2 2 2 5 5 3 2 Calcium binding and coiled-coil domain (CALCOCO1) like ABC_tran_CTD PF16326.5 EWC46967.1 - 0.0032 17.7 4.1 0.0032 17.7 4.1 10.4 6 3 4 10 10 9 1 ABC transporter C-terminal domain AAA_29 PF13555.6 EWC46967.1 - 0.0048 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Adeno_VII PF03228.14 EWC46967.1 - 0.077 13.6 0.3 0.31 11.7 0.3 2.1 1 0 0 1 1 1 0 Adenoviral core protein VII FtsK_SpoIIIE PF01580.18 EWC46967.1 - 0.22 10.9 0.0 0.22 10.9 0.0 4.7 5 1 1 6 6 6 0 FtsK/SpoIIIE family Spc7 PF08317.11 EWC46967.1 - 0.94 8.3 113.4 0.01 14.7 20.5 6.1 2 2 4 6 6 6 0 Spc7 kinetochore protein APG6_N PF17675.1 EWC46967.1 - 2.7 8.5 136.4 0.18 12.4 14.5 8.6 2 2 5 8 8 8 0 Apg6 coiled-coil region TPR_1 PF00515.28 EWC46968.1 - 1.7e-40 135.2 22.2 5.5e-08 32.3 0.0 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EWC46968.1 - 2.2e-35 117.9 26.8 7.7e-06 25.6 0.0 10.3 11 0 0 11 11 11 7 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC46968.1 - 1.4e-27 95.8 21.5 1.1e-20 73.6 0.8 5.6 4 1 1 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EWC46968.1 - 1e-26 90.9 12.7 0.00067 19.7 0.1 9.7 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_14 PF13428.6 EWC46968.1 - 5.5e-18 64.1 7.7 0.071 14.0 0.0 9.0 5 1 5 10 10 9 4 Tetratricopeptide repeat TPR_11 PF13414.6 EWC46968.1 - 4.5e-17 61.4 13.0 0.0057 16.3 0.0 10.2 8 1 4 12 12 12 5 TPR repeat TPR_12 PF13424.6 EWC46968.1 - 7.1e-17 61.5 19.5 0.0036 17.6 0.7 7.6 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 EWC46968.1 - 1e-15 58.1 11.8 0.00044 20.8 0.0 7.7 6 2 1 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 EWC46968.1 - 1.9e-15 57.1 14.1 4.9e-05 23.7 0.0 8.1 7 2 2 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 EWC46968.1 - 2.5e-12 46.2 9.3 0.92 10.0 0.0 8.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 EWC46968.1 - 1.2e-10 40.6 10.3 0.0011 18.8 0.4 7.5 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EWC46968.1 - 1.2e-06 28.6 0.9 1.8 8.8 0.0 5.4 3 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 EWC46968.1 - 1.2e-06 28.8 13.8 1.4 9.7 0.1 8.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 EWC46968.1 - 4.1e-05 22.9 3.9 0.12 11.6 0.1 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EWC46968.1 - 0.0053 16.6 2.7 20 5.2 0.1 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 EWC46968.1 - 0.037 14.1 6.5 1.1 9.4 0.1 5.6 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 EWC46968.1 - 0.049 13.0 0.2 1.1 8.6 0.0 2.8 1 1 2 3 3 3 0 MalT-like TPR region DUF3915 PF13054.6 EWC46968.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) SRP_TPR_like PF17004.5 EWC46968.1 - 0.2 11.7 1.4 3.6 7.7 0.0 3.1 3 0 0 3 3 3 0 Putative TPR-like repeat Sel1 PF08238.12 EWC46968.1 - 0.24 12.1 2.4 51 4.8 0.0 4.0 4 0 0 4 4 3 0 Sel1 repeat BTAD PF03704.17 EWC46968.1 - 1.6 9.2 5.0 12 6.3 0.9 3.8 2 1 2 4 4 4 0 Bacterial transcriptional activator domain Peptidase_M48 PF01435.18 EWC46969.1 - 3e-35 121.8 0.0 4.2e-34 118.0 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M48 Mito_carr PF00153.27 EWC46970.1 - 4e-43 145.2 2.4 3.3e-15 55.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Kinesin PF00225.23 EWC46971.1 - 9.1e-103 343.7 0.2 1.6e-102 342.8 0.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EWC46971.1 - 1.6e-59 200.2 2.5 6e-59 198.3 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding Filament PF00038.21 EWC46971.1 - 0.0048 16.5 9.8 0.0048 16.5 9.8 2.9 1 1 1 2 2 2 2 Intermediate filament protein zf-NOSIP PF15906.5 EWC46972.1 - 1.9e-06 27.9 0.3 4.4e-06 26.7 0.3 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_5 PF14634.6 EWC46972.1 - 1.6e-05 24.7 4.5 1.6e-05 24.7 4.5 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EWC46972.1 - 0.00015 22.1 16.1 0.0012 19.1 1.7 3.3 3 0 0 3 3 3 2 Ring finger domain Rtf2 PF04641.12 EWC46972.1 - 0.00016 21.2 2.3 0.00016 21.2 2.3 3.4 2 2 1 3 3 3 1 Rtf2 RING-finger zf-C3HC4_2 PF13923.6 EWC46972.1 - 0.00021 21.0 17.3 0.0017 18.2 2.2 3.3 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC46972.1 - 0.00021 21.2 4.0 0.00021 21.2 4.0 3.5 3 1 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EWC46972.1 - 0.00034 20.4 19.5 0.008 16.0 7.5 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC46972.1 - 0.00073 19.3 2.6 0.00073 19.3 2.6 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Vfa1 PF08432.10 EWC46972.1 - 0.0077 16.6 4.6 0.0088 16.4 1.4 2.3 2 0 0 2 2 2 1 AAA-ATPase Vps4-associated protein 1 zf-C3HC4_5 PF17121.5 EWC46972.1 - 0.032 14.1 1.5 0.097 12.6 1.5 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) OEP PF02321.18 EWC46972.1 - 0.063 13.1 3.7 5.7 6.7 0.0 2.5 3 0 0 3 3 3 0 Outer membrane efflux protein SVIP PF15811.5 EWC46972.1 - 0.085 13.3 9.8 0.27 11.7 9.8 1.8 1 0 0 1 1 1 0 Small VCP/p97-interacting protein FYVE PF01363.21 EWC46972.1 - 0.19 11.9 14.2 0.043 14.0 3.3 2.8 2 2 0 2 2 2 0 FYVE zinc finger DUF724 PF05266.14 EWC46972.1 - 0.21 11.4 3.3 0.36 10.6 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF2956 PF11169.8 EWC46972.1 - 2.1 8.6 8.9 3.7 7.8 4.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) zf-RING_6 PF14835.6 EWC46972.1 - 2.3 8.2 9.3 3.2 7.7 2.8 2.6 2 0 0 2 2 2 0 zf-RING of BARD1-type protein TBCA PF02970.16 EWC46972.1 - 3.5 8.0 8.7 0.82 10.0 1.3 2.5 1 1 1 2 2 2 0 Tubulin binding cofactor A Com_YlbF PF06133.11 EWC46972.1 - 6.1 7.5 10.0 35 5.0 10.0 2.0 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA IBR PF01485.21 EWC46972.1 - 6.3 7.1 12.0 0.49 10.7 0.4 2.8 3 0 0 3 3 2 0 IBR domain, a half RING-finger domain ATP11 PF06644.11 EWC46972.1 - 7.7 6.2 8.6 0.34 10.7 3.1 1.5 2 0 0 2 2 1 0 ATP11 protein CBFD_NFYB_HMF PF00808.23 EWC46973.1 - 2.6e-16 59.7 0.7 5.4e-16 58.6 0.7 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EWC46973.1 - 5.9e-06 26.7 0.4 5.9e-06 26.7 0.4 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.13 EWC46973.1 - 0.011 15.8 17.8 0.014 15.4 17.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tox-MPTase2 PF15638.6 EWC46973.1 - 0.18 11.5 1.2 0.3 10.8 1.2 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Glyco_transf_34 PF05637.12 EWC46974.1 - 1.4e-66 224.7 0.0 2e-66 224.2 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family EPL1 PF10513.9 EWC46974.1 - 0.0022 18.4 2.6 0.0032 17.9 2.6 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like Ndc1_Nup PF09531.10 EWC46974.1 - 0.0085 14.8 6.0 0.011 14.5 6.0 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup CCSAP PF15748.5 EWC46974.1 - 0.16 12.1 12.4 0.23 11.6 12.4 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated eIF-3_zeta PF05091.12 EWC46974.1 - 0.68 8.8 6.9 0.88 8.5 6.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 EWC46974.1 - 1.4 8.7 9.9 2 8.2 9.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 EWC46974.1 - 2.2 8.2 24.1 3 7.7 24.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 EWC46974.1 - 2.5 6.8 8.4 3.4 6.3 8.4 1.1 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 EWC46974.1 - 3.5 7.0 8.3 5 6.5 8.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 EWC46974.1 - 5.9 6.4 28.9 9.2 5.8 28.9 1.2 1 0 0 1 1 1 0 Spt20 family CBP_BcsG PF11658.8 EWC46974.1 - 7.3 4.9 5.7 11 4.3 5.7 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Pkinase PF00069.25 EWC46975.1 - 1.7e-41 142.3 0.0 2.6e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC46975.1 - 2.3e-25 89.4 0.0 3.3e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC46975.1 - 0.0041 15.9 0.0 0.0091 14.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EWC46975.1 - 0.0098 15.2 0.0 0.76 9.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EWC46975.1 - 0.17 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CTD_bind PF04818.13 EWC46976.1 - 1.2e-18 67.7 0.2 4.1e-18 66.0 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CREPT PF16566.5 EWC46976.1 - 0.00014 22.1 1.1 0.00041 20.5 1.1 1.8 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour Clathrin_lg_ch PF01086.17 EWC46977.1 - 7.9e-69 232.2 0.2 8.9e-69 232.1 0.2 1.0 1 0 0 1 1 1 1 Clathrin light chain rve_3 PF13683.6 EWC46977.1 - 0.1 12.4 0.4 0.24 11.2 0.3 1.8 1 1 0 1 1 1 0 Integrase core domain RsbRD_N PF14361.6 EWC46977.1 - 0.76 10.5 6.1 1.2 9.9 4.8 2.0 2 1 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain EF-hand_8 PF13833.6 EWC46978.1 - 1.2e-35 121.1 4.8 7.2e-15 54.6 0.2 3.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EWC46978.1 - 1.3e-33 112.0 7.4 8.3e-10 37.5 0.9 4.1 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EWC46978.1 - 1.3e-30 105.7 1.3 2.7e-19 69.4 1.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EWC46978.1 - 8.1e-23 78.4 4.3 5.9e-09 35.2 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EWC46978.1 - 9.5e-20 69.1 4.4 1.8e-05 24.0 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EWC46978.1 - 1.2e-13 51.2 0.2 4.1e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EWC46978.1 - 1.1e-07 31.8 0.7 0.0014 18.5 0.2 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 EWC46978.1 - 1e-06 28.7 0.2 0.0093 16.0 0.0 2.9 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.9 EWC46978.1 - 2.6e-06 27.7 0.1 0.00059 20.1 0.1 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 EWC46978.1 - 3.8e-06 26.9 0.6 8.8e-06 25.7 0.2 1.8 2 0 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EWC46978.1 - 0.00024 21.9 0.1 0.0028 18.5 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EWC46978.1 - 0.0015 18.5 0.2 1.8 8.5 0.1 2.1 1 1 1 2 2 2 2 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 EWC46978.1 - 0.0031 17.8 0.7 2.8 8.3 0.1 2.6 2 1 1 3 3 3 2 RNA polymerase Rpb4 DUF5580 PF17743.1 EWC46978.1 - 0.0047 15.5 0.0 0.0052 15.4 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EWC46978.1 - 0.02 14.7 0.7 0.65 9.9 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain dCache_2 PF08269.11 EWC46978.1 - 0.027 13.7 0.1 0.21 10.7 0.1 1.9 1 1 1 2 2 2 0 Cache domain Poly_export PF02563.16 EWC46978.1 - 0.046 14.0 0.0 0.18 12.0 0.0 2.1 1 1 1 2 2 2 0 Polysaccharide biosynthesis/export protein Peptidase_M24 PF00557.24 EWC46978.1 - 0.053 13.2 0.0 3.2 7.4 0.0 2.3 1 1 1 2 2 2 0 Metallopeptidase family M24 RuvA_C PF07499.13 EWC46978.1 - 0.1 13.1 0.1 13 6.3 0.0 2.9 3 0 0 3 3 3 0 RuvA, C-terminal domain Caleosin PF05042.13 EWC46978.1 - 0.14 12.1 1.2 17 5.3 0.0 3.2 1 1 2 3 3 3 0 Caleosin related protein DUF5132 PF17195.4 EWC46978.1 - 0.18 11.9 0.3 22 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) Dockerin_1 PF00404.18 EWC46978.1 - 0.22 11.7 5.3 0.47 10.7 0.9 2.6 1 1 2 3 3 3 0 Dockerin type I domain ABC_membrane PF00664.23 EWC46979.1 - 2.5e-59 201.2 7.5 3.3e-59 200.8 7.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EWC46979.1 - 8.2e-26 91.2 0.0 2.7e-25 89.5 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA PF00004.29 EWC46979.1 - 0.011 16.2 0.0 0.052 14.0 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC46979.1 - 0.014 15.8 0.0 0.056 13.8 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EWC46979.1 - 0.015 15.6 0.1 0.12 12.7 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EWC46979.1 - 0.058 13.1 0.1 0.15 11.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EWC46979.1 - 0.082 12.3 1.2 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EWC46979.1 - 0.09 12.3 0.4 1.4 8.4 0.4 2.3 1 1 0 1 1 1 0 AAA domain CDC37_N PF03234.14 EWC46980.1 - 7.2e-43 146.6 4.3 7.2e-43 146.6 4.3 3.1 4 0 0 4 4 4 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EWC46980.1 - 1.8e-35 121.4 0.1 3.8e-35 120.4 0.1 1.5 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EWC46980.1 - 1.8e-29 101.8 9.8 4.8e-29 100.4 5.6 3.3 2 1 0 2 2 2 1 Cdc37 C terminal domain DUF4570 PF15134.6 EWC46980.1 - 1.1 9.3 5.2 3.3 7.8 3.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) SmAKAP PF15127.6 EWC46980.1 - 2.9 9.1 5.5 1.6 9.9 0.2 3.4 2 1 1 3 3 3 0 Small membrane A-kinase anchor protein DUF4611 PF15387.6 EWC46980.1 - 2.9 8.1 7.6 2.4 8.4 0.5 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nucleoside_tran PF01733.18 EWC46981.1 - 5.1e-45 154.2 6.3 5.1e-45 154.2 6.3 2.1 1 1 0 2 2 2 1 Nucleoside transporter PAP2 PF01569.21 EWC46981.1 - 0.83 9.4 12.8 0.69 9.7 4.9 3.2 2 1 0 2 2 2 0 PAP2 superfamily DUF2070 PF09843.9 EWC46981.1 - 9.8 4.3 23.8 0.039 12.3 14.5 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) PI3_PI4_kinase PF00454.27 EWC46982.1 - 1.9e-35 122.9 0.0 2.1e-34 119.4 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 EWC46982.1 - 1.1e-14 54.1 0.0 2.8e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 EWC46982.1 - 0.0023 17.3 0.3 0.0046 16.4 0.3 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EWC46982.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF1018 PF06252.12 EWC46982.1 - 0.29 12.1 1.7 2.7 9.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1018) Say1_Mug180 PF10340.9 EWC46983.1 - 1.5e-26 93.2 0.0 1.7e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EWC46983.1 - 2.1e-22 80.0 0.0 2.9e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold YrhK PF14145.6 EWC46983.1 - 0.13 12.1 0.2 0.33 10.9 0.2 1.6 1 0 0 1 1 1 0 YrhK-like protein zf-RING_6 PF14835.6 EWC46984.1 - 0.063 13.2 6.5 0.1 12.5 6.5 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 EWC46984.1 - 0.48 10.3 11.4 0.77 9.7 11.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Velvet PF11754.8 EWC46985.1 - 1.7e-59 201.8 0.8 1.4e-36 126.7 0.2 2.4 1 1 1 2 2 2 2 Velvet factor ILVD_EDD PF00920.21 EWC46986.1 - 5.4e-201 668.7 0.3 6e-201 668.5 0.3 1.0 1 0 0 1 1 1 1 Dehydratase family 5_nucleotid_C PF02872.18 EWC46986.1 - 0.00063 20.0 0.0 0.013 15.7 0.0 2.5 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain FrhB_FdhB_N PF04422.13 EWC46986.1 - 0.039 14.1 0.5 0.44 10.7 0.0 2.9 4 0 0 4 4 4 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term RAI16-like PF10257.9 EWC46987.1 - 8.8e-73 245.2 0.2 1.3e-72 244.7 0.2 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Med20 PF08612.11 EWC46988.1 - 1.4e-32 112.9 0.0 3.5e-24 85.4 0.0 2.1 1 1 1 2 2 2 2 TATA-binding related factor (TRF) of subunit 20 of Mediator complex MBD_C PF14048.6 EWC46988.1 - 0.011 16.5 1.3 0.023 15.4 1.3 1.5 1 0 0 1 1 1 0 C-terminal domain of methyl-CpG binding protein 2 and 3 FAD_binding_1 PF00667.20 EWC46989.1 - 6.7e-50 169.7 0.0 1.3e-49 168.8 0.0 1.4 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 EWC46989.1 - 7.8e-10 39.4 0.0 4.7e-09 36.9 0.0 2.4 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain Acyltransferase PF01553.21 EWC46991.1 - 0.0097 15.5 0.0 0.028 14.0 0.0 1.7 1 1 0 1 1 1 1 Acyltransferase CBM_21 PF03370.13 EWC46992.1 - 5.7e-35 119.9 2.1 9.7e-35 119.2 2.1 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EWC46992.1 - 2.4e-10 40.9 0.9 4.4e-10 40.0 0.9 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) BolA PF01722.18 EWC46993.1 - 3.2e-09 36.9 0.0 9.4e-09 35.4 0.0 1.7 1 1 0 1 1 1 1 BolA-like protein DEAD PF00270.29 EWC46994.1 - 7.4e-39 133.3 0.1 1.1e-38 132.7 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC46994.1 - 9e-30 103.3 0.1 2.3e-29 101.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC46994.1 - 8.8e-05 22.6 0.0 0.00041 20.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CDC45 PF02724.14 EWC46994.1 - 0.0034 15.8 0.1 0.0044 15.4 0.1 1.2 1 0 0 1 1 1 1 CDC45-like protein Coilin_N PF15862.5 EWC46994.1 - 0.0067 16.2 0.3 0.077 12.8 0.7 2.1 2 0 0 2 2 2 1 Coilin N-terminus TLP-20 PF06088.11 EWC46994.1 - 0.04 13.8 0.4 0.08 12.8 0.4 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PGA2 PF07543.12 EWC46994.1 - 0.83 9.6 9.3 1.8 8.5 7.8 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 TSGP1 PF07771.11 EWC46994.1 - 1.8 8.7 8.6 3.4 7.8 8.6 1.4 1 0 0 1 1 1 0 Tick salivary peptide group 1 GEN1_C PF18380.1 EWC46994.1 - 5.4 8.0 7.7 14 6.7 7.7 1.6 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain PBP1_TM PF14812.6 EWC46994.1 - 8.1 6.9 10.4 28 5.2 10.4 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YEATS PF03366.16 EWC46995.1 - 1.1e-35 121.4 1.7 1.3e-35 121.2 0.9 1.5 2 0 0 2 2 2 1 YEATS family WD40 PF00400.32 EWC46996.1 - 2.4e-45 151.6 19.0 6e-07 30.1 0.1 8.5 7 1 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EWC46996.1 - 3.9e-14 52.3 2.1 6.4e-14 51.6 0.6 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EWC46996.1 - 4.3e-11 42.4 0.3 1.5e-10 40.7 0.3 2.1 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 EWC46996.1 - 3.3e-10 39.2 14.0 0.0038 15.9 0.5 5.8 3 1 3 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EWC46996.1 - 2e-07 31.2 3.5 2.3 8.6 0.1 5.7 2 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EWC46996.1 - 5e-05 23.2 3.1 0.00032 20.6 0.1 3.4 3 2 1 4 4 4 1 F-box WD40_like PF17005.5 EWC46996.1 - 0.0048 16.3 0.2 0.016 14.5 0.1 1.7 2 0 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 EWC46996.1 - 0.033 14.1 0.2 0.15 11.9 0.1 2.1 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EWC46996.1 - 0.07 11.9 1.1 8.5 5.0 0.1 2.8 2 1 0 2 2 2 0 Nup133 N terminal like APG17 PF04108.12 EWC46997.1 - 1.9e-111 373.0 8.3 3.3e-111 372.2 8.3 1.4 1 0 0 1 1 1 1 Autophagy protein Apg17 FadA PF09403.10 EWC46997.1 - 0.0028 18.1 4.5 0.74 10.3 0.2 3.2 2 1 0 2 2 2 2 Adhesion protein FadA ING PF12998.7 EWC46997.1 - 0.0095 16.5 5.2 1.1 9.9 0.0 3.5 2 1 1 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding IZUMO PF15005.6 EWC46997.1 - 0.041 14.4 1.8 0.16 12.5 0.2 2.8 3 1 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated PTRF_SDPR PF15237.6 EWC46997.1 - 0.066 12.8 0.5 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 PTRF/SDPR family HXXSHH PF07586.11 EWC46997.1 - 0.45 10.0 4.9 1.7 8.1 4.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1552) DUF1664 PF07889.12 EWC46997.1 - 0.56 10.3 2.9 4.7 7.3 0.0 3.3 3 2 0 3 3 3 0 Protein of unknown function (DUF1664) MscS_porin PF12795.7 EWC46997.1 - 0.76 9.3 6.3 1.1 8.8 2.2 2.5 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain IFT20 PF14931.6 EWC46997.1 - 0.98 9.6 6.5 7.4 6.8 0.1 3.6 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 ATP-synt_D PF01813.17 EWC46997.1 - 1.1 9.1 6.2 0.57 10.0 1.2 2.7 2 1 1 3 3 3 0 ATP synthase subunit D Fib_alpha PF08702.10 EWC46997.1 - 4.4 7.5 5.7 36 4.5 0.6 3.0 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Epimerase PF01370.21 EWC46998.1 - 0.00023 20.7 0.0 0.00029 20.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EWC46998.1 - 0.00025 21.0 0.0 0.00036 20.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EWC46998.1 - 0.0082 15.2 0.0 0.01 14.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family SYF2 PF08231.12 EWC46999.1 - 3e-50 170.7 17.0 3e-50 170.7 17.0 1.9 2 0 0 2 2 2 1 SYF2 splicing factor DUF4661 PF15576.6 EWC46999.1 - 1.7 8.5 4.8 2.5 8.0 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) DUF1899 PF08953.11 EWC47000.1 - 1.4e-34 117.8 0.2 2.3e-34 117.0 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EWC47000.1 - 8.2e-21 73.6 0.1 1.8e-20 72.6 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EWC47000.1 - 2.5e-14 53.4 8.2 0.0013 19.5 0.1 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47000.1 - 0.00035 20.8 0.0 2.2 8.6 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC47000.1 - 0.0073 15.0 0.1 0.23 10.1 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF1652 PF07865.11 EWC47000.1 - 0.1 12.4 0.1 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) Hat1_N PF10394.9 EWC47001.1 - 4.4e-33 114.8 0.0 7.7e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 EWC47001.1 - 1.5e-05 25.2 0.0 4.5e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EWC47001.1 - 0.0011 18.8 0.0 0.0026 17.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EWC47001.1 - 0.12 12.9 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CTP_synth_N PF06418.14 EWC47002.1 - 3.6e-87 292.0 0.0 4.7e-87 291.7 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EWC47002.1 - 3.7e-57 193.2 0.0 6.4e-57 192.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EWC47002.1 - 5.8e-06 26.2 0.1 2.7e-05 24.1 0.1 2.0 1 1 0 1 1 1 1 Peptidase C26 TPR_2 PF07719.17 EWC47003.1 - 0.00028 20.7 1.5 0.45 10.8 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47003.1 - 0.002 17.9 0.3 2.9 7.9 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47003.1 - 0.043 14.0 0.3 24 5.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DBD_HTH PF18430.1 EWC47003.1 - 0.094 12.5 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 Putative DNA-binding domain Sel1 PF08238.12 EWC47003.1 - 0.23 12.2 6.6 0.42 11.4 0.0 3.5 3 1 0 3 3 3 0 Sel1 repeat HMG_box PF00505.19 EWC47004.1 - 2.6e-12 46.9 0.4 6.6e-12 45.7 0.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EWC47004.1 - 4.8e-07 30.3 1.1 8.8e-07 29.4 1.1 1.4 1 0 0 1 1 1 1 HMG-box domain Zip PF02535.22 EWC47005.1 - 1.2e-31 110.2 19.5 7.7e-22 78.0 12.0 2.5 1 1 1 2 2 2 2 ZIP Zinc transporter Far-17a_AIG1 PF04750.14 EWC47005.1 - 0.055 12.8 2.5 1.3 8.2 0.0 3.0 3 0 0 3 3 3 0 FAR-17a/AIG1-like protein DUF4293 PF14126.6 EWC47005.1 - 0.18 12.1 3.7 0.63 10.3 1.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) DctQ PF04290.12 EWC47005.1 - 0.28 11.1 12.8 1.9 8.4 3.1 3.2 2 2 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component Cpn60_TCP1 PF00118.24 EWC47006.1 - 3.4e-150 500.9 8.3 3.8e-150 500.8 8.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MPTase-PolyVal PF18818.1 EWC47006.1 - 0.0016 18.5 0.0 0.003 17.6 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase superfamily domain AAA_10 PF12846.7 EWC47006.1 - 0.03 13.2 0.6 0.34 9.8 0.1 2.2 2 0 0 2 2 2 0 AAA-like domain EAL PF00563.20 EWC47006.1 - 0.047 13.2 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 EAL domain Alg6_Alg8 PF03155.15 EWC47007.1 - 1.4e-172 575.0 24.1 1.6e-172 574.8 24.1 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family PH_10 PF15411.6 EWC47008.1 - 8.1e-29 100.4 0.1 1.6e-28 99.4 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 EWC47008.1 - 6.5e-12 46.0 0.0 1.2e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EWC47008.1 - 2e-07 31.1 0.1 2.2e-06 27.7 0.0 2.5 2 1 0 2 2 2 1 von Willebrand factor type A domain zf-C3HC4_2 PF13923.6 EWC47008.1 - 0.00099 18.9 5.1 0.0021 17.9 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PH PF00169.29 EWC47008.1 - 0.001 19.5 0.1 0.003 18.1 0.1 1.7 1 0 0 1 1 1 1 PH domain zf-RING_2 PF13639.6 EWC47008.1 - 0.0012 19.1 5.7 0.0023 18.2 5.7 1.5 1 0 0 1 1 1 1 Ring finger domain Zn_ribbon_17 PF17120.5 EWC47008.1 - 0.0034 17.0 4.5 0.0034 17.0 4.5 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EWC47008.1 - 0.0096 15.9 5.2 0.017 15.1 5.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING-like PF08746.11 EWC47008.1 - 0.024 15.0 5.4 0.045 14.1 5.4 1.5 1 0 0 1 1 1 0 RING-like domain zf-rbx1 PF12678.7 EWC47008.1 - 0.046 14.0 3.2 0.11 12.8 3.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EWC47008.1 - 0.065 13.1 5.1 0.13 12.2 5.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EWC47008.1 - 0.13 12.3 0.2 0.29 11.2 0.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EWC47008.1 - 0.14 12.1 2.2 0.25 11.2 2.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WAC_Acf1_DNA_bd PF10537.9 EWC47009.1 - 6.6e-38 129.3 0.0 2.1e-37 127.7 0.0 1.9 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EWC47009.1 - 5e-20 71.8 0.8 5e-20 71.8 0.8 3.1 4 0 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EWC47009.1 - 2.2e-16 59.9 2.5 3.9e-16 59.1 2.5 1.4 1 0 0 1 1 1 1 DDT domain RhoGAP PF00620.27 EWC47010.1 - 5e-33 114.1 0.0 9.8e-33 113.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain RasGEF_N PF00618.20 EWC47010.1 - 4.4e-13 49.4 0.0 1.9e-12 47.4 0.0 2.2 1 1 0 1 1 1 1 RasGEF N-terminal motif RasGEF PF00617.19 EWC47010.1 - 7.1e-13 49.1 0.0 4.2e-12 46.6 0.0 2.3 2 0 0 2 2 2 1 RasGEF domain PH_9 PF15410.6 EWC47010.1 - 2.1e-06 28.1 0.0 0.00047 20.5 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EWC47010.1 - 0.00012 22.6 0.0 0.58 10.7 0.0 2.6 2 0 0 2 2 2 2 PH domain WD40 PF00400.32 EWC47011.1 - 1.4e-41 139.6 23.8 3.9e-07 30.7 0.3 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 EWC47011.1 - 3e-12 46.2 0.2 5.9e-12 45.3 0.2 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EWC47011.1 - 6e-10 39.3 2.2 0.05 13.9 0.0 5.6 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC47011.1 - 5.7e-08 31.9 7.8 1 7.9 0.1 6.0 1 1 5 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 EWC47011.1 - 3.9e-05 23.1 0.1 0.0023 17.3 0.0 2.8 1 1 2 3 3 3 2 WD40-like domain F-box PF00646.33 EWC47011.1 - 0.00018 21.3 0.2 0.00044 20.1 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EWC47011.1 - 0.011 15.3 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 F-box PALB2_WD40 PF16756.5 EWC47011.1 - 0.045 12.7 4.4 4.6 6.1 0.3 3.4 2 2 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain DUF155 PF02582.14 EWC47012.1 - 8.9e-54 182.2 0.6 8.9e-54 182.2 0.6 1.5 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 EWC47012.1 - 0.0015 19.0 0.0 0.0036 17.8 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 DUF5336 PF17270.2 EWC47012.1 - 0.069 12.8 1.3 0.12 12.0 1.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5336) E1_dh PF00676.20 EWC47013.1 - 7.1e-113 376.5 0.2 8.6e-113 376.2 0.2 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EWC47013.1 - 0.0016 17.7 0.0 0.0026 17.0 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EWC47013.1 - 0.018 14.8 1.5 0.037 13.8 1.5 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain WD40 PF00400.32 EWC47014.1 - 3.5e-40 135.2 13.2 4.5e-07 30.4 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47014.1 - 9.8e-12 45.0 0.1 0.019 15.3 0.0 6.0 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EWC47014.1 - 6.5e-06 26.2 0.0 0.17 11.8 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EWC47014.1 - 0.058 12.7 0.0 5.3 6.3 0.0 2.7 1 1 2 3 3 3 0 WD40-like domain Ge1_WD40 PF16529.5 EWC47014.1 - 0.092 11.7 0.0 29 3.5 0.0 3.1 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GDP_Man_Dehyd PF16363.5 EWC47015.1 - 2.8e-57 194.6 0.0 3.3e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EWC47015.1 - 6.9e-45 153.4 0.0 9.4e-45 152.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EWC47015.1 - 2.4e-10 39.9 0.0 3.5e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EWC47015.1 - 4.7e-08 32.5 0.0 2.2e-05 23.8 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EWC47015.1 - 2.1e-07 30.4 0.0 2.9e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EWC47015.1 - 3.8e-06 26.2 0.0 0.018 14.2 0.0 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein Motile_Sperm PF00635.26 EWC47016.1 - 1.5e-23 82.7 0.0 3.3e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ATG_C PF09333.11 EWC47016.1 - 0.0074 16.6 0.3 0.022 15.1 0.3 1.8 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Phage_GP20 PF06810.11 EWC47016.1 - 0.057 13.2 0.7 0.096 12.5 0.7 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF3292 PF11696.8 EWC47016.1 - 0.94 7.8 5.2 1.3 7.3 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3984 PF13136.6 EWC47017.1 - 1.4e-29 103.5 41.3 2e-28 99.8 34.0 3.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3984) Cut8 PF08559.10 EWC47018.1 - 9.8e-72 241.4 0.0 1.2e-71 241.1 0.0 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Stig1 PF04885.13 EWC47019.1 - 5e-07 30.3 18.4 5e-07 30.3 18.4 4.1 2 1 2 4 4 4 2 Stigma-specific protein, Stig1 PNTB PF02233.16 EWC47020.1 - 2.3e-171 570.8 25.0 2.3e-171 570.8 25.0 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EWC47020.1 - 3.6e-73 245.4 0.5 1.3e-72 243.6 0.5 2.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EWC47020.1 - 3.3e-44 150.5 0.0 8.1e-44 149.2 0.0 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EWC47020.1 - 1.5e-29 102.2 2.5 1.5e-29 102.2 2.5 4.2 2 1 1 3 3 3 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EWC47020.1 - 0.0037 16.6 0.1 2.7 7.3 0.0 2.8 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EWC47020.1 - 0.0037 16.5 0.2 0.033 13.4 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.22 EWC47020.1 - 0.011 15.5 0.7 0.063 13.0 0.1 2.6 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain CP_ATPgrasp_1 PF04174.13 EWC47020.1 - 0.02 13.9 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 A circularly permuted ATPgrasp GIDA PF01134.22 EWC47020.1 - 0.059 12.5 0.5 0.099 11.7 0.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Voltage_CLC PF00654.20 EWC47021.1 - 1.2e-88 297.7 26.8 1.2e-88 297.7 26.8 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel eIF-5_eIF-2B PF01873.17 EWC47022.1 - 1.2e-37 128.3 0.0 2.1e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EWC47022.1 - 4.2e-23 81.3 4.7 1.3e-22 79.7 0.0 3.2 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Zn-ribbon_8 PF09723.10 EWC47022.1 - 0.12 12.5 0.9 0.29 11.3 0.9 1.6 1 0 0 1 1 1 0 Zinc ribbon domain GREB1 PF15782.5 EWC47022.1 - 1 6.4 3.6 1.3 6.0 3.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_5 PF07728.14 EWC47023.1 - 1.8e-129 426.4 0.1 5.7e-20 71.7 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EWC47023.1 - 2.9e-45 152.8 2.3 1.2e-15 57.6 0.1 4.9 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_3 PF07726.11 EWC47023.1 - 5e-35 120.2 0.0 1.6e-10 41.0 0.0 8.3 8 0 0 8 8 8 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EWC47023.1 - 1.6e-28 99.4 0.5 6e-06 25.9 0.1 7.1 7 0 0 7 7 6 5 P-loop containing dynein motor region AAA PF00004.29 EWC47023.1 - 7.6e-28 97.6 0.2 9.9e-05 22.8 0.0 6.9 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC47023.1 - 1e-26 94.4 9.6 1.4e-06 28.8 0.0 8.4 7 1 0 7 7 6 6 AAA ATPase domain AAA_lid_5 PF17865.1 EWC47023.1 - 1.1e-26 93.0 0.7 1.4e-25 89.4 0.1 3.3 5 0 0 5 5 2 1 Midasin AAA lid domain Dynein_heavy PF03028.15 EWC47023.1 - 1.4e-24 86.5 0.0 5.1e-06 26.6 0.0 7.3 7 0 0 7 7 6 4 Dynein heavy chain region D6 P-loop domain Sigma54_activat PF00158.26 EWC47023.1 - 2e-19 69.9 0.0 0.0079 15.9 0.0 6.2 6 0 0 6 6 6 5 Sigma-54 interaction domain AAA_6 PF12774.7 EWC47023.1 - 8.6e-19 67.7 0.0 0.0021 17.1 0.0 9.2 8 1 0 8 8 8 3 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 EWC47023.1 - 1e-18 68.0 0.4 0.017 15.4 0.0 7.9 7 0 0 7 7 7 3 AAA domain AAA_18 PF13238.6 EWC47023.1 - 8.9e-18 65.1 0.5 0.19 12.3 0.0 7.4 6 0 0 6 6 6 3 AAA domain ABC_tran PF00005.27 EWC47023.1 - 1.5e-17 64.4 0.7 0.0066 17.0 0.0 7.4 7 1 0 7 7 6 2 ABC transporter AAA_33 PF13671.6 EWC47023.1 - 4.3e-17 62.6 0.9 0.0018 18.4 0.0 7.0 6 0 0 6 6 6 2 AAA domain Sigma54_activ_2 PF14532.6 EWC47023.1 - 1.6e-15 57.4 0.7 9.9e-05 22.5 0.0 6.1 6 0 0 6 6 6 2 Sigma-54 interaction domain TsaE PF02367.17 EWC47023.1 - 3.3e-15 56.2 0.7 0.096 12.7 0.0 6.2 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EWC47023.1 - 2.7e-14 53.3 0.0 0.3 10.8 0.0 7.6 7 1 0 7 7 7 3 AAA domain RNA_helicase PF00910.22 EWC47023.1 - 3e-14 53.3 1.5 0.041 14.3 0.0 7.3 7 0 0 7 7 7 2 RNA helicase T2SSE PF00437.20 EWC47023.1 - 6.9e-13 48.3 0.6 0.011 14.8 0.0 6.1 6 0 0 6 6 6 3 Type II/IV secretion system protein NACHT PF05729.12 EWC47023.1 - 1.2e-12 48.1 4.5 0.019 14.9 0.1 6.8 6 0 0 6 6 6 3 NACHT domain Zeta_toxin PF06414.12 EWC47023.1 - 1.3e-12 47.4 0.3 0.48 9.7 0.0 6.9 6 0 0 6 6 6 2 Zeta toxin AAA_14 PF13173.6 EWC47023.1 - 3e-12 46.7 0.0 0.015 15.3 0.0 7.3 7 0 0 7 7 7 1 AAA domain Mg_chelatase PF01078.21 EWC47023.1 - 2e-11 43.7 3.2 9.4 5.6 0.0 9.1 10 0 0 10 10 9 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EWC47023.1 - 4.2e-10 39.6 3.1 0.32 10.7 0.0 6.9 7 0 0 7 7 6 2 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 EWC47023.1 - 7.8e-10 38.4 0.3 1.8 8.4 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EWC47023.1 - 1.5e-09 37.8 0.3 0.9 9.1 0.0 5.3 5 0 0 5 5 5 2 AAA domain AAA_19 PF13245.6 EWC47023.1 - 5e-09 36.6 5.5 3.8 7.9 0.0 6.5 6 0 0 6 6 6 0 AAA domain DUF815 PF05673.13 EWC47023.1 - 1.3e-08 34.3 1.0 4.6 6.3 0.0 6.1 6 0 0 6 6 6 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 EWC47023.1 - 1.3e-08 34.9 2.3 2.4 8.0 0.0 6.1 6 0 0 6 6 6 2 RsgA GTPase IstB_IS21 PF01695.17 EWC47023.1 - 3e-08 33.6 0.1 3.4 7.4 0.0 6.3 6 0 0 6 6 6 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 EWC47023.1 - 4.4e-08 33.2 0.3 1.3 9.1 0.0 5.8 5 0 0 5 5 5 1 50S ribosome-binding GTPase Rad17 PF03215.15 EWC47023.1 - 1.2e-07 31.8 0.1 2.9 7.8 0.0 5.9 6 0 0 6 6 6 0 Rad17 P-loop domain SRP54 PF00448.22 EWC47023.1 - 2.4e-06 27.3 3.3 0.3 10.7 0.1 5.2 5 0 0 5 5 5 2 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 EWC47023.1 - 4e-06 26.9 0.1 1.5 8.7 0.0 5.8 6 0 0 6 6 5 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EWC47023.1 - 1.4e-05 25.4 8.8 6.1 7.1 0.0 6.4 7 0 0 7 7 5 0 AAA domain PduV-EutP PF10662.9 EWC47023.1 - 1.7e-05 24.6 0.4 0.3 10.8 0.0 4.5 4 0 0 4 4 4 1 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.15 EWC47023.1 - 2.2e-05 24.5 0.1 9 6.3 0.0 5.7 6 0 0 6 6 6 0 Type III restriction enzyme, res subunit DEAD PF00270.29 EWC47023.1 - 3e-05 23.9 0.1 6.7 6.5 0.0 5.2 5 0 0 5 5 4 0 DEAD/DEAH box helicase TniB PF05621.11 EWC47023.1 - 5e-05 22.8 0.6 2.3 7.6 0.0 4.6 6 0 0 6 6 4 1 Bacterial TniB protein TIP49 PF06068.13 EWC47023.1 - 7.1e-05 22.2 1.3 0.44 9.7 0.1 4.5 5 0 0 5 5 5 1 TIP49 P-loop domain dNK PF01712.19 EWC47023.1 - 0.00013 21.9 3.7 3.5 7.4 0.0 5.9 6 0 0 6 6 6 0 Deoxynucleoside kinase Bac_DnaA PF00308.18 EWC47023.1 - 0.00014 21.7 1.0 5.2 6.8 0.0 4.9 5 0 0 5 5 5 0 Bacterial dnaA protein ATPase PF06745.13 EWC47023.1 - 0.00015 21.2 1.1 8.4 5.7 0.0 5.8 7 0 0 7 7 6 0 KaiC Roc PF08477.13 EWC47023.1 - 0.00016 21.9 2.3 25 5.1 0.0 6.1 6 0 0 6 6 5 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 EWC47023.1 - 0.00038 20.4 8.0 1.7 8.5 0.0 5.3 6 0 0 6 6 4 1 NTPase AAA_24 PF13479.6 EWC47023.1 - 0.0004 20.2 0.2 33 4.1 0.0 5.8 6 0 0 6 6 6 0 AAA domain AAA_8 PF12780.7 EWC47023.1 - 0.00041 19.8 0.0 10 5.4 0.0 5.1 5 0 0 5 5 5 0 P-loop containing dynein motor region D4 SRPRB PF09439.10 EWC47023.1 - 0.00071 19.1 1.5 13 5.2 0.0 5.2 6 0 0 6 6 5 0 Signal recognition particle receptor beta subunit AAA_23 PF13476.6 EWC47023.1 - 0.0012 19.4 16.1 22 5.5 0.0 7.8 7 0 0 7 7 5 0 AAA domain cobW PF02492.19 EWC47023.1 - 0.0013 18.4 5.4 11 5.6 0.0 6.3 7 0 0 7 7 7 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EWC47023.1 - 0.0017 17.4 0.0 1.2 8.1 0.0 3.3 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 EWC47023.1 - 0.0065 16.9 4.4 28 5.1 0.0 5.7 5 0 0 5 5 4 0 AAA domain FtsK_SpoIIIE PF01580.18 EWC47023.1 - 0.0088 15.4 0.2 14 5.0 0.0 4.6 5 0 0 5 5 5 0 FtsK/SpoIIIE family PhoH PF02562.16 EWC47023.1 - 0.011 15.2 0.7 17 4.8 0.0 4.3 4 0 0 4 4 4 0 PhoH-like protein RPW8 PF05659.11 EWC47023.1 - 0.02 14.6 1.1 0.058 13.1 0.0 2.3 2 0 0 2 2 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TrwB_AAD_bind PF10412.9 EWC47023.1 - 0.068 12.1 3.6 14 4.4 0.1 4.5 5 0 0 5 5 5 0 Type IV secretion-system coupling protein DNA-binding domain CPT PF07931.12 EWC47023.1 - 0.071 12.9 1.5 30 4.4 0.1 4.5 4 1 0 4 4 3 0 Chloramphenicol phosphotransferase-like protein CbiA PF01656.23 EWC47023.1 - 0.11 12.6 2.2 64 3.6 0.2 5.2 5 0 0 5 5 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain FeoB_N PF02421.18 EWC47023.1 - 0.16 11.5 0.2 81 2.7 0.0 4.2 4 0 0 4 4 4 0 Ferrous iron transport protein B DUF87 PF01935.17 EWC47023.1 - 0.16 12.1 3.4 0.75 9.8 0.1 3.7 4 0 0 4 4 2 0 Helicase HerA, central domain VWA_2 PF13519.6 EWC47023.1 - 0.22 12.2 1.5 0.72 10.5 0.1 2.7 2 0 0 2 2 1 0 von Willebrand factor type A domain ATP_bind_1 PF03029.17 EWC47023.1 - 0.39 10.5 7.3 39 3.9 0.0 5.4 6 0 0 6 6 5 0 Conserved hypothetical ATP binding protein AAA_11 PF13086.6 EWC47023.1 - 3.9 7.2 28.1 9.2 6.0 0.0 7.8 9 0 0 9 9 6 0 AAA domain CRIM PF16978.5 EWC47024.1 - 6.3e-41 139.8 0.0 1.6e-40 138.5 0.0 1.8 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EWC47024.1 - 3e-32 111.2 0.2 5.2e-32 110.4 0.2 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology RBD PF02196.15 EWC47024.1 - 1.4e-05 25.1 0.2 3.5e-05 23.8 0.2 1.7 1 0 0 1 1 1 1 Raf-like Ras-binding domain PHD PF00628.29 EWC47025.1 - 3.3e-11 42.9 9.4 8.6e-10 38.4 3.7 2.6 2 0 0 2 2 2 2 PHD-finger zf-RING_2 PF13639.6 EWC47025.1 - 2.7e-08 34.0 1.1 2.7e-08 34.0 1.1 3.2 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EWC47025.1 - 1e-05 25.7 12.6 1.2e-05 25.5 4.2 2.9 3 1 0 3 3 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EWC47025.1 - 1.8e-05 24.5 1.2 1.8e-05 24.5 1.2 2.8 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EWC47025.1 - 2.6e-05 24.0 2.0 2.6e-05 24.0 2.0 3.1 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC47025.1 - 0.00035 20.5 0.8 0.038 14.0 0.0 3.7 4 1 0 4 4 3 2 RING-type zinc-finger zf-ANAPC11 PF12861.7 EWC47025.1 - 0.0004 20.4 5.1 0.004 17.2 0.1 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EWC47025.1 - 0.00048 20.0 2.7 0.00048 20.0 2.7 2.8 2 1 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EWC47025.1 - 0.00069 19.4 3.8 0.00069 19.4 3.8 2.5 2 2 0 2 2 2 1 Prokaryotic RING finger family 4 PHD_2 PF13831.6 EWC47025.1 - 0.00075 19.0 1.4 0.00075 19.0 1.4 2.0 2 0 0 2 2 2 1 PHD-finger zf-C3HC4_3 PF13920.6 EWC47025.1 - 0.0012 18.6 0.8 0.0012 18.6 0.8 3.4 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EWC47025.1 - 0.0018 17.9 0.4 0.0018 17.9 0.4 2.5 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 EWC47025.1 - 0.025 14.5 7.1 0.076 13.0 1.1 2.8 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Dynactin_p62 PF05502.13 EWC47025.1 - 0.03 13.1 0.7 0.052 12.3 0.7 1.3 1 0 0 1 1 1 0 Dynactin p62 family zinc_ribbon_16 PF17034.5 EWC47025.1 - 0.093 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon like family zf-PHD-like PF15446.6 EWC47025.1 - 0.14 11.8 0.2 0.14 11.8 0.2 1.9 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Vps39_2 PF10367.9 EWC47025.1 - 0.53 10.8 1.7 1.3 9.5 1.1 1.9 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 Ribosomal_L37ae PF01780.19 EWC47026.1 - 8.4e-41 138.0 7.6 9.4e-41 137.8 7.6 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EWC47026.1 - 0.021 14.8 1.5 0.034 14.1 1.5 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Elf1 PF05129.13 EWC47026.1 - 0.041 13.9 1.0 0.065 13.3 1.0 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-RING_13 PF17977.1 EWC47026.1 - 0.063 13.4 2.2 0.086 13.0 2.2 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-BED PF02892.15 EWC47026.1 - 0.07 13.2 4.2 1.9 8.6 0.6 2.2 1 1 1 2 2 2 0 BED zinc finger DUF1451 PF07295.11 EWC47026.1 - 0.072 13.1 0.6 0.094 12.7 0.6 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf-H2C2_2 PF13465.6 EWC47026.1 - 0.15 12.5 1.3 0.43 11.1 0.4 2.0 2 0 0 2 2 2 0 Zinc-finger double domain C1_2 PF03107.16 EWC47026.1 - 0.17 12.3 2.5 8.6 6.8 0.1 2.1 1 1 1 2 2 2 0 C1 domain A2L_zn_ribbon PF08792.10 EWC47026.1 - 0.31 10.8 2.5 0.76 9.6 0.1 2.0 2 0 0 2 2 2 0 A2L zinc ribbon domain US30 PF17624.2 EWC47027.1 - 0.098 11.7 0.7 0.18 10.8 0.7 1.3 1 0 0 1 1 1 0 Family of unknown function ISG65-75 PF11727.8 EWC47027.1 - 0.26 10.5 4.9 0.37 10.0 3.6 1.8 2 0 0 2 2 2 0 Invariant surface glycoprotein SRPRB PF09439.10 EWC47028.1 - 4.6e-28 97.9 0.1 3e-27 95.2 0.1 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EWC47028.1 - 0.0048 16.3 0.0 0.0067 15.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EWC47028.1 - 0.0063 16.0 0.0 0.029 13.8 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EWC47028.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EWC47028.1 - 0.047 13.2 0.0 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EWC47028.1 - 0.17 11.6 0.0 0.91 9.3 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 EWC47028.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF3517 PF12030.8 EWC47029.1 - 1.2e-73 248.0 0.0 1.9e-73 247.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 EWC47029.1 - 3.4e-41 141.4 0.0 6.1e-41 140.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EWC47029.1 - 4.6e-20 72.5 0.0 9.3e-20 71.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PseudoU_synth_1 PF01416.20 EWC47030.1 - 4.4e-10 40.0 0.0 1.1e-07 32.2 0.0 3.2 3 0 0 3 3 3 2 tRNA pseudouridine synthase UPF0113_N PF17833.1 EWC47031.1 - 2.4e-29 101.7 0.0 3.7e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EWC47031.1 - 1.2e-22 79.9 0.0 2.4e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain SRP_TPR_like PF17004.5 EWC47032.1 - 6.1e-19 68.2 0.4 2e-17 63.3 0.0 2.5 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 EWC47032.1 - 4.9e-13 49.3 9.6 4.9e-13 49.3 9.6 2.6 3 0 0 3 3 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 EWC47032.1 - 7.9e-09 35.9 17.7 0.076 13.5 0.0 7.6 6 1 2 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC47032.1 - 1.5e-06 28.3 11.5 0.021 15.0 0.7 5.4 6 0 0 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EWC47032.1 - 0.0023 18.4 10.3 59 4.6 0.2 7.6 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47032.1 - 0.003 17.3 6.9 3.6 7.6 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47032.1 - 0.0035 18.0 15.3 0.61 10.8 0.0 5.6 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EWC47032.1 - 0.017 14.8 3.0 1 9.1 0.0 4.4 5 0 0 5 5 5 0 TPR repeat TPR_2 PF07719.17 EWC47032.1 - 0.017 15.2 13.5 3.8 7.9 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47032.1 - 0.02 15.7 10.0 8.2 7.5 0.0 6.1 5 1 3 8 8 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47032.1 - 0.06 13.6 11.4 3.1 8.2 0.0 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat Hormone_3 PF00159.18 EWC47032.1 - 0.081 13.0 0.3 5 7.3 0.1 2.6 2 0 0 2 2 2 0 Pancreatic hormone peptide Lectin_leg-like PF03388.13 EWC47033.1 - 2e-30 105.8 0.0 3e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family S36_mt PF10937.8 EWC47033.1 - 0.041 15.5 0.9 0.093 14.3 0.9 1.6 1 0 0 1 1 1 0 Ribosomal protein S36, mitochondrial DUF1664 PF07889.12 EWC47033.1 - 0.042 13.9 0.5 0.15 12.1 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 EWC47033.1 - 0.17 11.3 5.7 0.23 10.8 5.7 1.2 1 0 0 1 1 1 0 FAM76 protein TFIIE_alpha PF02002.17 EWC47034.1 - 7.8e-19 67.5 0.7 1.5e-18 66.6 0.7 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 EWC47034.1 - 0.0052 16.3 0.7 0.011 15.2 0.7 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding zf-TFIIB PF13453.6 EWC47034.1 - 0.088 12.2 0.8 0.16 11.3 0.8 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger zf-ribbon_3 PF13248.6 EWC47034.1 - 0.24 10.8 0.2 0.24 10.8 0.2 2.5 3 0 0 3 3 3 0 zinc-ribbon domain RNA_pol_3_Rpc31 PF11705.8 EWC47034.1 - 1.1 9.4 15.8 1.3 9.3 10.0 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 NOC3p PF07540.11 EWC47035.1 - 8.9e-29 99.8 0.6 8.9e-29 99.8 0.6 3.0 4 0 0 4 4 4 1 Nucleolar complex-associated protein CBF PF03914.17 EWC47035.1 - 1.9e-19 70.3 0.1 1.9e-19 70.3 0.1 2.3 2 1 0 2 2 2 1 CBF/Mak21 family RepA1_leader PF08048.12 EWC47035.1 - 0.19 12.0 2.2 5 7.5 0.5 2.6 2 0 0 2 2 2 0 Tap RepA1 leader peptide Mrpl_C PF18502.1 EWC47035.1 - 3.4 8.0 8.0 1.7 9.0 0.1 3.0 3 0 0 3 3 3 0 54S ribosomal protein L8 C-terminal domain Ubiq_cyt_C_chap PF03981.12 EWC47036.1 - 7.7e-27 94.1 1.6 1.8e-26 92.9 1.7 1.5 2 0 0 2 2 2 1 Ubiquinol-cytochrome C chaperone Met_synt_B12 PF02965.17 EWC47036.1 - 0.048 13.1 0.0 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 Vitamin B12 dependent methionine synthase, activation domain DUF2937 PF11157.8 EWC47036.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) TIP41 PF04176.13 EWC47037.1 - 2.6e-68 228.9 0.1 3.3e-68 228.5 0.1 1.1 1 0 0 1 1 1 1 TIP41-like family PhoLip_ATPase_C PF16212.5 EWC47038.1 - 8.6e-83 277.9 22.2 8.6e-83 277.9 22.2 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EWC47038.1 - 6.3e-26 89.9 7.2 6.3e-26 89.9 7.2 2.4 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EWC47038.1 - 1.1e-12 47.8 0.0 6.1e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EWC47038.1 - 7.8e-10 39.4 2.5 2e-05 25.0 0.3 3.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EWC47038.1 - 6.3e-08 32.4 0.1 1.4e-07 31.2 0.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EWC47038.1 - 0.0015 18.3 0.4 0.0059 16.4 0.4 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase MRP-L46 PF11788.8 EWC47039.1 - 6e-25 88.3 0.5 1.2e-24 87.3 0.5 1.5 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 Cofilin_ADF PF00241.20 EWC47040.1 - 5e-32 110.3 0.0 2.3e-17 62.9 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Mito_carr PF00153.27 EWC47041.1 - 4.1e-66 218.9 1.0 3.2e-22 78.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SCA7 PF08313.12 EWC47042.1 - 3.6e-31 106.9 0.3 1.2e-30 105.2 0.3 1.9 1 0 0 1 1 1 1 SCA7, zinc-binding domain TAF4 PF05236.14 EWC47042.1 - 0.00045 20.0 14.1 0.00067 19.5 14.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family DUF2043 PF09740.9 EWC47042.1 - 0.067 13.9 1.2 0.15 12.7 1.2 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) MMR_HSR1 PF01926.23 EWC47043.1 - 3.6e-09 36.7 0.1 1.2e-08 35.0 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EWC47043.1 - 3e-05 24.0 0.0 9.7e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 EWC47043.1 - 0.00092 19.7 0.2 0.00092 19.7 0.2 2.7 2 0 0 2 2 2 1 ABC transporter VSG_B PF13206.6 EWC47043.1 - 0.0032 16.8 12.7 0.0047 16.2 12.7 1.2 1 0 0 1 1 1 1 Trypanosomal VSG domain IIGP PF05049.13 EWC47043.1 - 0.0036 16.4 0.1 0.0036 16.4 0.1 2.1 3 0 0 3 3 3 1 Interferon-inducible GTPase (IIGP) GPS2_interact PF15784.5 EWC47043.1 - 0.0087 16.5 6.5 0.0087 16.5 6.5 2.6 1 1 1 2 2 1 1 G-protein pathway suppressor 2-interacting domain AAA_23 PF13476.6 EWC47043.1 - 0.013 16.0 0.2 0.013 16.0 0.2 2.7 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EWC47043.1 - 0.033 14.3 11.7 0.48 10.5 0.2 3.6 2 2 1 3 3 2 0 Dynamin family AAA_21 PF13304.6 EWC47043.1 - 0.034 14.0 0.5 0.065 13.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Exonuc_VII_L PF02601.15 EWC47043.1 - 0.068 12.7 7.0 0.1 12.2 7.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_29 PF13555.6 EWC47043.1 - 0.1 12.4 0.4 0.26 11.1 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EWC47043.1 - 0.15 12.3 1.5 0.32 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.8 EWC47043.1 - 0.25 8.8 21.9 0.35 8.3 21.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EWC47043.1 - 0.29 10.0 18.4 0.44 9.4 18.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 EWC47043.1 - 0.38 8.6 9.5 0.53 8.1 9.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATG16 PF08614.11 EWC47043.1 - 0.53 10.5 20.6 1.2 9.3 20.6 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Lant_dehydr_C PF14028.6 EWC47043.1 - 0.75 9.3 6.4 1.2 8.6 6.4 1.3 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term TPR_MLP1_2 PF07926.12 EWC47043.1 - 0.99 9.5 26.6 0.7 10.0 14.6 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF87 PF01935.17 EWC47043.1 - 1.1 9.2 8.5 0.91 9.6 0.3 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_18 PF13238.6 EWC47043.1 - 1.4 9.4 4.7 3.9 8.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain DASH_Spc19 PF08287.11 EWC47043.1 - 1.7 8.5 18.5 2.5 8.0 17.7 1.6 1 1 0 1 1 1 0 Spc19 Peptidase_S46 PF10459.9 EWC47043.1 - 2 7.0 10.3 2.8 6.5 10.3 1.1 1 0 0 1 1 1 0 Peptidase S46 YabA PF06156.13 EWC47043.1 - 2 9.1 17.4 0.88 10.2 4.1 2.4 1 1 1 2 2 2 0 Initiation control protein YabA APG6_N PF17675.1 EWC47043.1 - 3 8.4 28.4 1.5 9.3 13.3 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region PIN_8 PF18476.1 EWC47043.1 - 3.1 7.6 11.1 5 6.9 11.1 1.3 1 0 0 1 1 1 0 PIN like domain DUF5094 PF17015.5 EWC47043.1 - 3.7 7.6 11.9 6.4 6.9 11.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Asp-B-Hydro_N PF05279.11 EWC47043.1 - 4.1 7.4 14.1 8.5 6.4 14.1 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Cnn_1N PF07989.11 EWC47043.1 - 4.7 7.4 16.4 0.5 10.6 3.6 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 AAA_11 PF13086.6 EWC47043.1 - 4.8 6.9 11.1 1.9 8.2 8.6 1.6 2 0 0 2 2 1 0 AAA domain Jnk-SapK_ap_N PF09744.9 EWC47043.1 - 6.5 7.0 24.5 34 4.6 24.5 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 AAA_13 PF13166.6 EWC47043.1 - 7.9 5.0 14.0 14 4.2 14.0 1.3 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 EWC47043.1 - 8 4.9 16.5 21 3.6 16.5 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A 5_nucleotid PF05761.14 EWC47043.1 - 8.6 5.1 8.6 27 3.5 8.5 1.7 2 0 0 2 2 2 0 5' nucleotidase family SKA2 PF16740.5 EWC47043.1 - 8.8 6.2 16.7 45 3.9 8.1 2.4 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Nup88 PF10168.9 EWC47043.1 - 9.1 3.9 13.3 14 3.3 13.3 1.2 1 0 0 1 1 1 0 Nuclear pore component DUF1664 PF07889.12 EWC47043.1 - 9.8 6.2 10.3 9.5 6.3 4.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ketoacyl-synt PF00109.26 EWC47045.1 - 6e-56 189.8 0.5 6e-56 189.8 0.5 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EWC47045.1 - 2e-26 92.3 0.3 5.3e-26 91.0 0.3 1.7 1 1 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EWC47045.1 - 0.00055 19.4 0.1 0.0012 18.3 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain HTH_31 PF13560.6 EWC47045.1 - 0.097 13.0 0.2 23 5.4 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain KAsynt_C_assoc PF16197.5 EWC47045.1 - 0.15 12.5 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension ACP_syn_III PF08545.10 EWC47045.1 - 0.27 11.1 1.8 17 5.3 0.1 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III CAF1 PF04857.20 EWC47046.1 - 1.3e-72 244.7 0.0 1.5e-72 244.5 0.0 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease ABC_trans_N PF14510.6 EWC47047.1 - 0.053 14.1 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC-transporter N-terminal Pkinase PF00069.25 EWC47048.1 - 5.6e-71 239.0 0.0 7.7e-71 238.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47048.1 - 1.2e-42 146.0 0.0 1.6e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC47048.1 - 5.1e-08 32.6 0.0 2.6e-06 27.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EWC47048.1 - 0.00056 19.3 0.1 0.00083 18.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EWC47048.1 - 0.0015 17.4 0.0 0.0018 17.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EWC47048.1 - 0.041 13.5 0.0 0.21 11.1 0.0 1.9 1 1 1 2 2 2 0 RIO1 family FTA2 PF13095.6 EWC47048.1 - 0.048 13.3 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EWC47048.1 - 0.084 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EWC47048.1 - 0.1 11.5 2.1 0.14 11.1 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EWC47048.1 - 0.12 11.4 0.0 0.29 10.2 0.0 1.5 2 0 0 2 2 2 0 Seadornavirus VP7 Peptidase_M76 PF09768.9 EWC47049.1 - 2.4e-65 219.5 1.1 8.4e-65 217.7 1.1 1.7 1 1 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EWC47049.1 - 0.02 14.8 0.1 0.031 14.1 0.1 1.6 1 0 0 1 1 1 0 SprT-like family Peptidase_M91 PF14891.6 EWC47049.1 - 0.12 12.7 0.1 0.17 12.2 0.1 1.2 1 0 0 1 1 1 0 Effector protein DUF2039 PF10217.9 EWC47049.1 - 0.13 12.6 3.0 1.4 9.4 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2039) AA_kinase PF00696.28 EWC47050.1 - 3.3e-39 134.9 0.7 4.7e-39 134.4 0.7 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EWC47050.1 - 2.3e-15 56.3 0.7 6.3e-15 54.9 0.7 1.8 1 0 0 1 1 1 1 PUA domain DEAD PF00270.29 EWC47051.1 - 1.7e-26 93.0 0.0 3.2e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC47051.1 - 1.5e-14 54.3 0.0 3.5e-14 53.1 0.0 1.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47051.1 - 0.0081 16.2 0.0 0.037 14.0 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PH PF00169.29 EWC47052.1 - 7.3e-08 32.9 0.0 2.5e-07 31.2 0.0 2.0 1 1 0 1 1 1 1 PH domain RNase_P_pop3 PF08228.11 EWC47053.1 - 0.065 13.3 0.1 0.24 11.5 0.1 1.8 1 1 0 1 1 1 0 RNase P subunit Pop3 CAP_N PF01213.19 EWC47053.1 - 2.2 7.7 4.8 3.5 7.0 4.8 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Hydrophobin PF01185.18 EWC47054.1 - 0.0056 17.3 15.9 0.012 16.2 14.8 2.0 1 1 1 2 2 2 2 Fungal hydrophobin PALP PF00291.25 EWC47055.1 - 7e-69 232.5 0.3 8.7e-69 232.2 0.3 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EWC47055.1 - 2.6e-15 56.6 1.9 1.5e-09 38.2 0.0 3.3 4 0 0 4 4 4 2 CBS domain DHHC PF01529.20 EWC47056.1 - 1.2e-32 112.8 8.2 1.2e-32 112.8 8.2 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EWC47056.1 - 1.1e-30 106.1 0.1 3.3e-13 50.0 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EWC47056.1 - 3.1e-24 84.3 0.3 1.5e-07 31.6 0.1 6.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.6 EWC47056.1 - 4.8e-24 81.8 1.0 7.4e-07 29.0 0.1 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EWC47056.1 - 1.1e-23 83.0 0.6 1.5e-05 25.2 0.1 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EWC47056.1 - 2.2e-21 75.9 0.9 1.5e-05 25.4 0.1 4.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Heliorhodopsin PF18761.1 EWC47056.1 - 0.047 13.0 4.3 0.082 12.2 4.3 1.3 1 0 0 1 1 1 0 Heliorhodopsin Voltage_CLC PF00654.20 EWC47058.1 - 8e-90 301.6 15.8 8e-90 301.6 15.8 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EWC47058.1 - 0.092 13.2 0.0 1.7 9.1 0.0 2.4 2 0 0 2 2 2 0 CBS domain Lipase_GDSL_2 PF13472.6 EWC47060.1 - 7.7e-19 68.8 0.1 1.3e-18 68.0 0.1 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EWC47060.1 - 2.4e-15 57.0 0.0 2.9e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Isochorismatase PF00857.20 EWC47062.1 - 1.1e-28 100.7 0.1 2.4e-28 99.5 0.1 1.5 1 1 0 1 1 1 1 Isochorismatase family Lectin_leg-like PF03388.13 EWC47063.1 - 2.8e-68 229.7 0.0 3.4e-68 229.4 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EWC47063.1 - 3.2e-07 30.6 0.1 4.7e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EWC47063.1 - 3.6e-05 23.4 0.0 0.0011 18.6 0.0 2.1 1 1 0 1 1 1 1 Legume lectin domain ATG27 PF09451.10 EWC47063.1 - 0.096 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 Zip PF02535.22 EWC47064.1 - 1.9e-23 83.2 4.5 3e-21 76.0 2.5 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter GWT1 PF06423.12 EWC47064.1 - 0.00035 20.7 0.1 0.00071 19.7 0.1 1.5 1 0 0 1 1 1 1 GWT1 Colicin_V PF02674.16 EWC47064.1 - 0.25 11.3 10.1 0.041 13.9 1.3 2.4 2 0 0 2 2 2 0 Colicin V production protein ICMT PF04140.14 EWC47065.1 - 3e-27 94.8 0.8 3e-27 94.8 0.8 1.6 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EWC47065.1 - 9.4e-12 45.3 1.4 9.4e-12 45.3 1.4 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EWC47065.1 - 0.0041 16.7 0.6 0.0044 16.6 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Pkinase PF00069.25 EWC47067.1 - 1.8e-49 168.5 0.0 5.9e-49 166.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47067.1 - 2.7e-17 62.9 0.1 1.5e-16 60.4 0.0 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC47067.1 - 0.048 13.0 0.2 3.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 EWC47067.1 - 0.1 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2458 PF10454.9 EWC47068.1 - 7.3e-33 113.6 7.9 1.2e-31 109.7 4.8 3.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2458) ERG2_Sigma1R PF04622.12 EWC47070.1 - 1.6e-76 256.3 0.1 2e-76 256.0 0.1 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein zf-AN1 PF01428.16 EWC47072.1 - 0.0063 16.7 18.2 0.013 15.6 7.2 3.1 2 1 1 3 3 3 2 AN1-like Zinc finger C5HCH PF17982.1 EWC47072.1 - 4.1 7.6 16.9 0.97 9.6 9.9 2.5 2 1 0 2 2 2 0 NSD Cys-His rich domain DUF1180 PF06679.12 EWC47074.1 - 1.6 9.1 6.7 1.9 8.8 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) U1snRNP70_N PF12220.8 EWC47075.1 - 0.74 10.5 7.2 1.5 9.5 1.4 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal zf-C3HC4_3 PF13920.6 EWC47075.1 - 1.2 9.1 7.5 9 6.3 4.4 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Acetyltransf_10 PF13673.7 EWC47076.1 - 6.4e-12 45.5 0.0 4.7e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EWC47076.1 - 1.1e-11 44.9 0.0 1.5e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EWC47076.1 - 3.2e-06 27.5 0.0 0.00026 21.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EWC47076.1 - 0.0055 16.8 0.0 0.018 15.2 0.0 1.8 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EWC47076.1 - 0.02 15.0 0.0 0.21 11.7 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 EWC47076.1 - 0.098 12.4 0.2 0.2 11.4 0.2 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ FR47 PF08445.10 EWC47076.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein VWA PF00092.28 EWC47077.1 - 4.7e-09 36.7 0.0 8.6e-09 35.9 0.0 1.4 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EWC47077.1 - 8.2e-06 25.8 0.0 1.3e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EWC47077.1 - 0.00058 20.5 0.0 0.0019 18.8 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain Pex14_N PF04695.13 EWC47077.1 - 0.16 12.6 5.2 0.26 11.9 5.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RRM_1 PF00076.22 EWC47078.1 - 1.1e-08 34.8 0.0 1.9e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EWC47078.1 - 0.00017 21.5 0.0 0.00037 20.4 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EWC47078.1 - 0.0026 17.6 0.0 0.008 16.0 0.0 1.8 1 1 0 1 1 1 1 Occluded RNA-recognition motif DUF1906 PF08924.11 EWC47078.1 - 0.067 13.3 0.3 0.2 11.8 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1906) Pex24p PF06398.11 EWC47079.1 - 6.9e-84 281.9 1.6 8.7e-84 281.6 1.6 1.0 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Yip1 PF04893.17 EWC47080.1 - 4.5e-09 36.3 13.3 4.5e-09 36.3 13.3 1.6 1 1 0 1 1 1 1 Yip1 domain DUF2070 PF09843.9 EWC47080.1 - 0.71 8.1 8.2 0.92 7.7 8.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Med3 PF11593.8 EWC47082.1 - 0.0033 16.7 0.3 0.0034 16.6 0.3 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Peptidase_M15 PF01427.17 EWC47082.1 - 0.035 13.8 0.0 0.044 13.5 0.0 1.0 1 0 0 1 1 1 0 D-ala-D-ala dipeptidase Spt20 PF12090.8 EWC47083.1 - 2.4e-42 145.1 0.0 2.4e-42 145.1 0.0 5.5 2 1 2 4 4 4 1 Spt20 family NTP_transferase PF00483.23 EWC47084.1 - 2.4e-10 40.4 0.0 3.9e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EWC47084.1 - 2.9e-07 30.0 9.8 0.0024 17.5 1.9 2.9 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EWC47084.1 - 2e-05 25.0 0.0 3.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 EWC47084.1 - 0.0045 16.0 1.4 0.01 14.8 1.4 1.5 1 1 0 1 1 1 1 L-fucokinase CTP_transf_3 PF02348.19 EWC47084.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase DUF4954 PF16314.5 EWC47084.1 - 0.23 9.5 3.2 0.54 8.3 3.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) CDP-OH_P_transf PF01066.21 EWC47085.1 - 1.6e-13 51.2 0.6 1.6e-13 51.2 0.6 1.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF2046 PF09755.9 EWC47086.1 - 0.0021 17.4 0.2 0.056 12.7 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) FlaC_arch PF05377.11 EWC47086.1 - 0.039 14.4 1.4 0.078 13.4 0.3 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Nnf1 PF03980.14 EWC47086.1 - 0.04 14.3 0.9 4.3 7.7 0.6 2.4 2 0 0 2 2 2 0 Nnf1 Cnn_1N PF07989.11 EWC47086.1 - 0.047 13.9 0.6 0.047 13.9 0.6 1.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 RsbRD_N PF14361.6 EWC47086.1 - 0.072 13.8 1.6 1.2 9.8 0.1 2.6 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Leu_zip PF15294.6 EWC47086.1 - 0.084 12.4 1.8 0.15 11.6 1.8 1.3 1 0 0 1 1 1 0 Leucine zipper DUF5320 PF17253.2 EWC47086.1 - 0.092 13.8 0.4 0.78 10.8 0.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) CASP_C PF08172.12 EWC47086.1 - 0.15 11.4 0.2 0.15 11.4 0.2 2.4 2 1 0 2 2 2 0 CASP C terminal DivIC PF04977.15 EWC47086.1 - 0.17 11.7 0.1 0.17 11.7 0.1 1.8 2 0 0 2 2 2 0 Septum formation initiator HALZ PF02183.18 EWC47086.1 - 0.21 11.8 3.3 0.47 10.7 3.3 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF3972 PF13118.6 EWC47086.1 - 0.3 11.5 2.7 0.22 12.0 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) Sec2p PF06428.11 EWC47086.1 - 0.57 10.2 5.5 0.15 12.0 1.6 1.9 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p HSCB_C PF07743.13 EWC47086.1 - 1.8 9.1 5.3 4.8 7.7 1.2 2.3 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain ZapB PF06005.12 EWC47086.1 - 3.4 8.2 9.7 0.17 12.3 3.3 1.9 2 0 0 2 2 2 0 Cell division protein ZapB Tmemb_cc2 PF10267.9 EWC47086.1 - 3.5 6.7 6.5 6.4 5.8 6.5 1.5 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DNA_ligase_OB_2 PF14743.6 EWC47087.1 - 3.1e-27 94.4 0.4 7.4e-27 93.2 0.4 1.6 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.21 EWC47087.1 - 3.2e-12 46.5 0.0 6.1e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EWC47087.1 - 6e-05 23.4 0.0 0.00014 22.2 0.0 1.7 1 1 0 1 1 1 1 RNA ligase PBP1_TM PF14812.6 EWC47087.1 - 0.022 15.1 29.3 0.23 11.9 11.2 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pox_Ag35 PF03286.14 EWC47087.1 - 0.065 13.0 28.7 0.022 14.5 11.9 2.2 1 1 1 2 2 2 0 Pox virus Ag35 surface protein BUD22 PF09073.10 EWC47087.1 - 0.068 12.5 23.8 0.12 11.7 23.8 1.3 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 EWC47087.1 - 0.25 10.6 24.9 0.58 9.4 2.8 2.3 2 0 0 2 2 2 0 NOA36 protein RR_TM4-6 PF06459.12 EWC47087.1 - 0.34 10.7 13.0 0.027 14.3 7.5 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TLP-20 PF06088.11 EWC47087.1 - 1 9.2 11.5 0.68 9.8 1.7 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) FCP1_C PF09309.10 EWC47087.1 - 1.5 8.6 26.6 0.89 9.4 7.7 2.4 1 1 0 2 2 2 0 FCP1, C-terminal FYDLN_acid PF09538.10 EWC47087.1 - 6.7 7.5 30.5 14 6.4 9.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) GMC_oxred_N PF00732.19 EWC47090.1 - 2.1e-38 132.4 1.1 1.1e-37 130.0 0.1 2.1 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EWC47090.1 - 4.6e-24 85.6 0.0 2.6e-23 83.2 0.0 2.2 2 0 0 2 2 2 1 GMC oxidoreductase CPSF73-100_C PF11718.8 EWC47091.1 - 2.2e-70 236.6 0.0 3.1e-70 236.1 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EWC47091.1 - 5.2e-31 107.2 0.0 2e-30 105.3 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EWC47091.1 - 1.2e-22 80.4 0.3 3.7e-22 78.7 0.3 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EWC47091.1 - 3.8e-20 72.7 0.9 9e-20 71.5 0.9 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 EWC47091.1 - 6.2e-13 48.5 0.0 1.3e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EWC47091.1 - 9.8e-05 22.0 1.1 0.00033 20.2 0.6 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EWC47091.1 - 0.00016 21.6 0.3 0.00071 19.5 0.3 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EWC47091.1 - 0.0011 18.2 0.0 0.0028 16.9 0.0 1.6 2 0 0 2 2 2 1 Putative beta-lactamase-like family zf-C2H2 PF00096.26 EWC47092.1 - 1.8e-09 37.6 13.0 0.00012 22.3 1.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC47092.1 - 5.2e-06 26.6 13.1 1e-05 25.8 2.2 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC47092.1 - 0.0001 22.8 10.0 0.1 13.5 0.6 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EWC47092.1 - 0.051 13.9 3.8 2.8 8.3 1.0 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EWC47092.1 - 0.41 10.7 0.1 0.41 10.7 0.1 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger Fungal_trans PF04082.18 EWC47093.1 - 5.5e-24 84.6 0.0 9.9e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mtc PF03820.17 EWC47094.1 - 4.4e-113 377.5 0.0 4.9e-113 377.3 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier TauD PF02668.16 EWC47095.1 - 7e-49 167.0 0.1 8.6e-49 166.7 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Glyco_hydro_15 PF00723.21 EWC47096.1 - 1.5e-56 192.1 0.0 1.3e-54 185.7 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 Sacchrp_dh_NADP PF03435.18 EWC47097.1 - 0.029 14.6 0.0 0.053 13.8 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ANAPC10 PF03256.16 EWC47098.1 - 7.9e-55 185.4 0.0 1.1e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) SDA1 PF05285.12 EWC47098.1 - 0.0018 17.7 34.6 0.0024 17.4 34.6 1.1 1 0 0 1 1 1 1 SDA1 Mpp10 PF04006.12 EWC47098.1 - 0.021 13.3 29.3 0.034 12.6 29.3 1.2 1 0 0 1 1 1 0 Mpp10 protein PITH PF06201.13 EWC47098.1 - 0.1 12.8 0.0 0.1 12.8 0.0 1.8 2 1 0 2 2 2 0 PITH domain BSP_II PF05432.11 EWC47098.1 - 0.12 12.1 31.5 0.21 11.3 31.5 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RNA_polI_A34 PF08208.11 EWC47098.1 - 0.82 9.7 15.9 1.2 9.2 15.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Zip PF02535.22 EWC47098.1 - 2 7.5 3.4 2.6 7.2 3.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EWC47098.1 - 9 4.9 8.5 12 4.6 8.5 1.1 1 0 0 1 1 1 0 Presenilin Iso_dh PF00180.20 EWC47099.1 - 3.1e-126 421.2 0.0 3.8e-126 420.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase MFS_1 PF07690.16 EWC47100.1 - 4e-30 104.9 38.7 4e-30 104.9 38.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1772 PF08592.11 EWC47100.1 - 0.039 14.3 18.3 0.34 11.2 0.0 4.0 2 2 3 5 5 5 0 Domain of unknown function (DUF1772) CoatB PF10389.9 EWC47101.1 - 0.042 13.7 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage coat protein B Fungal_trans PF04082.18 EWC47102.1 - 2.3e-22 79.3 0.0 4.6e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC47102.1 - 2.4e-07 30.8 13.5 5.7e-07 29.5 13.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mto2_bdg PF12808.7 EWC47102.1 - 0.19 12.1 3.2 0.2 12.0 1.1 2.1 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Med6 PF04934.14 EWC47103.1 - 5.1e-41 139.6 0.4 7.7e-41 139.0 0.4 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component Corona_nucleoca PF00937.18 EWC47103.1 - 0.46 9.5 7.2 0.89 8.5 7.2 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein HSP20 PF00011.21 EWC47104.1 - 1.3e-11 44.5 0.1 2.1e-11 43.8 0.1 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Fungal_TACC PF12709.7 EWC47105.1 - 3e-11 43.6 33.5 2.7e-10 40.6 7.5 4.3 4 0 0 4 4 4 2 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4407 PF14362.6 EWC47105.1 - 0.0085 15.5 5.8 0.0085 15.5 5.8 3.7 2 1 2 4 4 4 1 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.8 EWC47105.1 - 0.0086 16.1 45.0 0.013 15.5 1.5 5.3 3 2 2 5 5 5 3 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 EWC47105.1 - 0.011 15.9 6.0 0.011 15.9 6.0 5.4 2 2 4 6 6 6 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 EWC47105.1 - 0.015 15.3 25.7 0.93 9.5 2.4 4.4 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 EWC47105.1 - 0.017 15.2 3.1 0.017 15.2 3.1 4.7 4 0 0 4 4 4 0 bZIP transcription factor ORF6C PF10552.9 EWC47105.1 - 0.019 15.0 0.5 0.019 15.0 0.5 2.9 4 0 0 4 4 2 0 ORF6C domain Fez1 PF06818.15 EWC47105.1 - 0.021 15.3 36.5 0.036 14.5 13.4 2.9 3 0 0 3 3 3 0 Fez1 UvrA_inter PF17760.1 EWC47105.1 - 0.03 14.4 0.8 0.12 12.4 0.1 2.3 2 0 0 2 2 2 0 UvrA interaction domain KxDL PF10241.9 EWC47105.1 - 0.051 13.9 0.3 0.051 13.9 0.3 4.2 3 1 0 3 3 3 0 Uncharacterized conserved protein JIP_LZII PF16471.5 EWC47105.1 - 0.07 13.3 0.3 0.07 13.3 0.3 5.3 3 2 2 5 5 5 0 JNK-interacting protein leucine zipper II AAA_13 PF13166.6 EWC47105.1 - 0.1 11.2 32.8 0.1 11.2 16.9 3.1 2 1 1 3 3 3 0 AAA domain WXG100 PF06013.12 EWC47105.1 - 0.11 12.7 17.9 0.42 10.9 0.3 4.4 4 1 0 4 4 4 0 Proteins of 100 residues with WXG Macoilin PF09726.9 EWC47105.1 - 0.23 10.0 30.3 9.9 4.6 18.5 3.1 1 1 1 2 2 2 0 Macoilin family DUF4201 PF13870.6 EWC47105.1 - 0.28 10.9 29.7 4.4 7.0 3.9 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Atg14 PF10186.9 EWC47105.1 - 0.37 9.8 30.3 0.15 11.1 4.5 3.4 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Osmo_CC PF08946.10 EWC47105.1 - 0.53 10.6 8.6 1.1 9.6 4.8 3.2 2 0 0 2 2 2 0 Osmosensory transporter coiled coil MscS_porin PF12795.7 EWC47105.1 - 0.63 9.5 40.5 0.021 14.4 13.2 4.0 4 1 0 4 4 4 0 Mechanosensitive ion channel porin domain SlyX PF04102.12 EWC47105.1 - 0.75 10.4 26.1 0.72 10.5 1.9 5.6 3 2 2 5 5 5 0 SlyX Filament PF00038.21 EWC47105.1 - 1.7 8.2 37.6 2.2 7.8 5.3 2.6 1 1 1 2 2 2 0 Intermediate filament protein YabA PF06156.13 EWC47105.1 - 1.8 9.3 26.4 1.7 9.3 0.3 4.8 2 1 2 4 4 4 0 Initiation control protein YabA Baculo_PEP_C PF04513.12 EWC47105.1 - 2.3 8.3 10.4 6.9 6.7 0.9 3.6 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIC PF04977.15 EWC47105.1 - 5.2 6.9 34.7 2 8.3 4.1 5.5 4 3 0 4 4 4 0 Septum formation initiator Spc7 PF08317.11 EWC47105.1 - 8.1 5.2 42.1 4.3 6.1 1.9 3.6 1 1 3 4 4 4 0 Spc7 kinetochore protein DUF2935 PF11155.8 EWC47105.1 - 9 6.6 6.8 19 5.6 2.1 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Cnn_1N PF07989.11 EWC47105.1 - 9.6 6.4 31.0 5.5 7.2 10.3 4.4 3 2 1 4 4 4 0 Centrosomin N-terminal motif 1 ADIP PF11559.8 EWC47105.1 - 10 6.2 37.0 0.48 10.5 1.6 4.5 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding Glyoxalase_3 PF13468.6 EWC47106.1 - 6.5e-26 91.5 0.0 1e-25 90.9 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain DUF3824 PF12868.7 EWC47107.1 - 0.015 16.0 6.5 0.015 16.0 6.5 8.6 3 2 4 7 7 7 0 Domain of unknwon function (DUF3824) SfLAP PF11139.8 EWC47107.1 - 6.9 6.0 8.5 3 7.2 1.0 2.1 1 1 1 2 2 2 0 Sap, sulfolipid-1-addressing protein AA_permease PF00324.21 EWC47109.1 - 3.6e-85 286.4 37.1 6e-47 160.3 9.8 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EWC47109.1 - 7.2e-22 77.8 24.3 1.1e-21 77.2 24.3 1.2 1 0 0 1 1 1 1 Amino acid permease DUF2420 PF10336.9 EWC47111.1 - 4.5e-14 52.4 0.0 8.3e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Adap_comp_sub PF00928.21 EWC47112.1 - 2.4e-14 53.3 0.0 3.7e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EWC47112.1 - 1.3e-06 28.4 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1835 PF08874.10 EWC47112.1 - 0.096 12.9 0.4 0.17 12.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) Mg_trans_NIPA PF05653.14 EWC47113.1 - 1.5e-102 342.7 22.7 1.9e-102 342.4 22.7 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EWC47113.1 - 0.00017 21.7 7.4 0.00017 21.7 7.4 3.6 3 1 0 3 3 3 3 EamA-like transporter family GAT PF03127.14 EWC47114.1 - 2.9e-16 59.5 0.8 2e-15 56.8 0.3 2.1 2 0 0 2 2 2 1 GAT domain VHS PF00790.19 EWC47114.1 - 0.00026 20.9 0.0 0.00051 19.9 0.0 1.5 1 0 0 1 1 1 1 VHS domain DMAP_binding PF06464.11 EWC47115.1 - 3.8e-12 47.0 0.9 7.8e-12 46.0 0.0 1.9 2 0 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.12 EWC47115.1 - 1.7e-06 27.9 0.0 2.9e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 Gas vesicle protein G ATF7IP_BD PF16788.5 EWC47115.1 - 0.0018 18.4 0.5 0.0028 17.8 0.5 1.3 1 0 0 1 1 1 1 ATF-interacting protein binding domain AMP-binding PF00501.28 EWC47116.1 - 2.2e-65 220.9 0.1 1.4e-23 83.2 0.0 4.2 4 0 0 4 4 4 4 AMP-binding enzyme NRDE-2 PF08424.10 EWC47117.1 - 1.5e-90 303.6 0.0 2.2e-86 289.9 0.0 3.2 3 0 0 3 3 3 2 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 EWC47117.1 - 0.0012 19.5 4.7 3.4 8.8 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat Dsh_C PF12316.8 EWC47117.1 - 0.71 10.2 18.0 1.3 9.4 18.0 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Apt1 PF10351.9 EWC47117.1 - 3.9 6.2 12.6 5.9 5.6 12.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EWC47117.1 - 4.4 6.0 8.4 6.8 5.4 8.4 1.2 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 EWC47120.1 - 1.9e-39 136.5 39.3 7.1e-39 134.6 37.9 6.4 3 2 0 5 5 5 2 Domain of unknown function (DUF4045) Gelsolin PF00626.22 EWC47120.1 - 2.2e-10 40.3 0.0 0.071 13.0 0.0 3.8 3 0 0 3 3 3 3 Gelsolin repeat Arf PF00025.21 EWC47121.1 - 2.5e-67 225.7 1.8 2.8e-67 225.5 1.8 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EWC47121.1 - 6e-13 49.1 0.1 8.3e-13 48.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EWC47121.1 - 8.3e-13 48.3 0.0 9.6e-13 48.0 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EWC47121.1 - 9.9e-13 48.0 0.8 6.6e-07 28.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EWC47121.1 - 6.5e-10 38.8 0.1 7.8e-10 38.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EWC47121.1 - 8.1e-09 35.2 0.0 9.5e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EWC47121.1 - 7.7e-08 32.4 0.0 1.1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EWC47121.1 - 1.9e-05 24.3 0.0 0.00051 19.6 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EWC47121.1 - 0.03 13.9 0.3 0.058 12.9 0.3 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B MeaB PF03308.16 EWC47121.1 - 0.1 11.5 0.1 0.46 9.4 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TsaE PF02367.17 EWC47121.1 - 0.11 12.5 0.2 0.72 9.9 0.0 1.9 1 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Peptidase_S8 PF00082.22 EWC47122.1 - 1.1e-21 77.4 0.0 2.4e-21 76.3 0.0 1.6 1 0 0 1 1 1 1 Subtilase family Fungal_lectin_2 PF18647.1 EWC47122.1 - 6.9e-07 29.7 0.1 3.8e-06 27.3 0.1 2.2 1 1 0 1 1 1 1 Alpha-galactosyl-binding fungal lectin DEAD PF00270.29 EWC47123.1 - 2.5e-44 151.1 0.1 5e-44 150.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC47123.1 - 7.2e-29 100.4 0.4 9.9e-28 96.7 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EWC47123.1 - 0.0024 16.7 3.0 0.011 14.5 0.2 2.9 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Nre_N PF04894.12 EWC47124.1 - 0.0032 17.3 0.0 0.0052 16.7 0.0 1.2 1 0 0 1 1 1 1 Archaeal Nre, N-terminal UBA_4 PF14555.6 EWC47125.1 - 4.7e-11 42.3 0.0 8.9e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EWC47125.1 - 1.6e-08 34.6 0.0 3.1e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 UBX domain ubiquitin PF00240.23 EWC47126.1 - 6.5e-09 35.4 0.0 1.1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2630 PF10944.8 EWC47126.1 - 0.04 14.4 4.1 0.15 12.6 4.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) TBK1_ULD PF18396.1 EWC47126.1 - 0.049 13.6 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD PF11976.8 EWC47126.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EWC47126.1 - 0.22 11.6 0.0 0.43 10.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like zf-Mss51 PF13824.6 EWC47127.1 - 4.5e-24 84.3 9.3 1.1e-23 83.0 8.9 1.9 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EWC47127.1 - 0.17 12.0 3.5 0.27 11.3 3.5 1.3 1 0 0 1 1 1 0 MYND finger HSP70 PF00012.20 EWC47128.1 - 1.5e-56 191.8 0.2 1.5e-56 191.8 0.2 3.7 3 1 1 4 4 4 2 Hsp70 protein MreB_Mbl PF06723.13 EWC47128.1 - 2.5e-05 23.2 0.2 0.00067 18.6 0.7 2.7 3 0 0 3 3 3 1 MreB/Mbl protein BLOC1_2 PF10046.9 EWC47128.1 - 0.063 13.6 5.5 5.9 7.3 0.7 3.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RPW8 PF05659.11 EWC47128.1 - 0.17 11.5 0.7 1.1 8.9 0.1 2.4 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Spectrin PF00435.21 EWC47128.1 - 0.83 10.2 7.7 5.3 7.6 2.6 2.9 2 0 0 2 2 2 0 Spectrin repeat DUF2347 PF09804.9 EWC47129.1 - 6.5e-67 226.1 0.0 5.8e-66 223.0 0.0 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EWC47129.1 - 9.8e-43 146.6 0.0 3.9e-42 144.7 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4484) Macoilin PF09726.9 EWC47131.1 - 0.12 10.9 8.9 0.15 10.6 8.9 1.2 1 0 0 1 1 1 0 Macoilin family SRP-alpha_N PF04086.13 EWC47131.1 - 0.79 9.6 17.1 0.13 12.1 12.6 1.7 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Rtf2 PF04641.12 EWC47131.1 - 2.5 7.4 4.5 4.6 6.5 4.5 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger Pol_alpha_B_N PF08418.10 EWC47131.1 - 3.7 7.4 9.3 0.82 9.6 6.3 1.6 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal PAP1 PF08601.10 EWC47131.1 - 4.6 6.9 13.9 6 6.5 13.9 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 CCDC106 PF15794.5 EWC47131.1 - 4.9 6.8 12.0 0.19 11.4 6.0 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 MAP70 PF07058.11 EWC47131.1 - 5.8 5.5 8.4 8.1 5.1 8.4 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Presenilin PF01080.17 EWC47131.1 - 6.7 5.4 7.0 11 4.7 7.0 1.3 1 0 0 1 1 1 0 Presenilin Peptidase_M24 PF00557.24 EWC47132.1 - 2.4e-59 200.5 0.1 3.9e-59 199.8 0.1 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EWC47132.1 - 3.3e-19 68.8 0.0 6.6e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain LSM PF01423.22 EWC47133.1 - 5.3e-17 61.3 0.1 6.1e-17 61.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain Pan3_PK PF18101.1 EWC47134.1 - 7e-66 220.4 0.7 1.4e-65 219.5 0.7 1.5 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EWC47134.1 - 3.8e-05 23.2 0.0 6.7e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DnaJ PF00226.31 EWC47135.1 - 1.6e-21 76.2 0.0 2.6e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain ANAPC4 PF12896.7 EWC47136.1 - 6.1e-57 192.4 0.0 9.1e-57 191.9 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EWC47136.1 - 2.5e-24 85.4 0.0 9.2e-24 83.6 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EWC47136.1 - 0.038 13.6 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 PQQ-like domain Zn_ribbon_17 PF17120.5 EWC47136.1 - 0.15 11.7 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type HEAT PF02985.22 EWC47137.1 - 1.5e-15 55.9 24.7 1.6e-05 24.7 0.3 10.8 14 0 0 14 14 13 3 HEAT repeat HEAT_EZ PF13513.6 EWC47137.1 - 1.1e-14 54.6 13.5 8.5e-09 35.7 0.0 8.9 7 3 3 10 10 10 2 HEAT-like repeat HEAT_2 PF13646.6 EWC47137.1 - 4.4e-08 33.4 14.5 0.0099 16.2 0.2 7.1 5 2 3 8 8 7 4 HEAT repeats IBN_N PF03810.19 EWC47137.1 - 7.2e-07 29.0 2.8 2e-05 24.4 0.7 3.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain Arm PF00514.23 EWC47137.1 - 2.9e-05 23.9 7.7 0.76 9.9 0.0 6.4 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EWC47137.1 - 3.5e-05 23.5 0.0 0.0073 15.9 0.0 3.7 3 1 1 4 4 4 1 CLASP N terminal UME PF08064.13 EWC47137.1 - 0.00018 21.3 0.9 3.4 7.6 0.0 5.3 5 2 1 6 6 6 1 UME (NUC010) domain Adaptin_N PF01602.20 EWC47137.1 - 0.00091 17.9 1.2 10 4.5 0.0 4.4 2 1 1 4 4 4 1 Adaptin N terminal region MMS19_N PF14500.6 EWC47137.1 - 0.0037 16.9 3.4 2.1 7.8 0.0 4.0 4 1 1 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II NUC173 PF08161.12 EWC47137.1 - 0.0061 16.2 0.2 3.2 7.4 0.0 4.4 4 0 0 4 4 4 1 NUC173 domain LegC3_N PF18654.1 EWC47137.1 - 0.053 12.8 1.0 0.094 11.9 1.0 1.3 1 0 0 1 1 1 0 LegC3 N-terminal coiled-coil domain ADSL_C PF10397.9 EWC47137.1 - 0.082 13.5 3.2 0.16 12.5 0.2 3.0 3 0 0 3 3 3 0 Adenylosuccinate lyase C-terminus TIP120 PF08623.10 EWC47137.1 - 0.092 12.5 1.7 1.9 8.2 0.0 3.8 4 1 1 5 5 5 0 TATA-binding protein interacting (TIP20) HEAT_PBS PF03130.16 EWC47137.1 - 1.4 9.8 11.2 45 5.1 0.0 6.9 8 0 0 8 8 7 0 PBS lyase HEAT-like repeat MMS1_N PF10433.9 EWC47138.1 - 6.4e-160 533.0 0.0 8.8e-160 532.5 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EWC47138.1 - 6.3e-100 334.6 0.0 9.4e-98 327.5 0.0 3.1 3 0 0 3 3 3 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 EWC47138.1 - 0.077 13.3 0.0 0.67 10.3 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EWC47138.1 - 0.096 12.7 0.0 16 5.6 0.0 3.8 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region PHTB1_N PF14727.6 EWC47138.1 - 0.19 11.0 0.0 0.47 9.8 0.0 1.6 1 0 0 1 1 1 0 PTHB1 N-terminus PS_Dcarbxylase PF02666.15 EWC47139.1 - 3e-67 226.1 0.0 1.9e-66 223.4 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase F-box-like PF12937.7 EWC47140.1 - 0.0004 20.2 6.7 0.0014 18.5 1.1 2.8 3 0 0 3 3 3 2 F-box-like FAM220 PF15487.6 EWC47140.1 - 0.067 12.8 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 FAM220 family F-box PF00646.33 EWC47140.1 - 0.11 12.4 0.4 0.11 12.4 0.4 2.0 2 0 0 2 2 2 0 F-box domain LysM PF01476.20 EWC47141.1 - 0.0098 15.9 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 LysM domain BP28CT PF08146.12 EWC47142.1 - 5.7e-34 117.2 0.1 1.2e-33 116.1 0.1 1.6 1 0 0 1 1 1 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EWC47142.1 - 5.5e-22 78.3 1.4 5.5e-22 78.3 1.4 4.0 5 0 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 EWC47142.1 - 1.6e-06 27.8 7.1 0.058 13.7 0.0 6.3 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 EWC47142.1 - 2e-05 24.9 8.2 0.0035 17.7 0.1 5.0 5 0 0 5 5 5 2 HEAT repeats Adaptin_N PF01602.20 EWC47142.1 - 6.2e-05 21.7 2.1 2.1 6.8 0.1 4.2 5 0 0 5 5 5 3 Adaptin N terminal region HEAT_EZ PF13513.6 EWC47142.1 - 0.00046 20.6 23.7 0.076 13.5 0.0 7.0 8 0 0 8 8 8 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EWC47142.1 - 0.0093 16.5 0.0 0.75 10.4 0.0 3.1 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EWC47142.1 - 0.025 14.6 0.4 5.7 7.0 0.1 3.1 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EWC47142.1 - 0.17 11.8 1.3 12 5.7 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF3385) SelB-wing_2 PF09106.11 EWC47142.1 - 5.2 7.4 5.7 15 5.9 0.2 3.7 3 0 0 3 3 3 0 Elongation factor SelB, winged helix HEAT_EZ PF13513.6 EWC47143.1 - 1.5e-31 108.4 10.0 2.7e-15 56.5 0.0 11.0 8 3 4 12 12 11 5 HEAT-like repeat HEAT PF02985.22 EWC47143.1 - 8e-22 75.5 16.0 0.00026 21.0 0.0 11.1 12 0 0 12 12 11 3 HEAT repeat HEAT_2 PF13646.6 EWC47143.1 - 4.3e-17 62.3 2.7 2.2e-05 24.7 0.0 7.0 6 1 2 8 8 8 3 HEAT repeats Cnd1 PF12717.7 EWC47143.1 - 2.3e-10 40.7 0.3 0.053 13.6 0.0 4.8 5 1 0 5 5 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EWC47143.1 - 4.4e-10 40.0 0.0 0.0074 16.9 0.0 5.4 3 2 1 6 6 6 2 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 EWC47143.1 - 7.4e-09 35.4 0.1 2.3e-07 30.6 0.0 3.4 3 0 0 3 3 3 1 Importin-beta N-terminal domain Adaptin_N PF01602.20 EWC47143.1 - 3.8e-07 29.0 0.0 0.0011 17.7 0.0 3.8 3 2 1 4 4 4 2 Adaptin N terminal region CLASP_N PF12348.8 EWC47143.1 - 3.9e-06 26.6 0.8 1.3 8.5 0.1 6.4 5 2 1 6 6 6 1 CLASP N terminal DUF3437 PF11919.8 EWC47143.1 - 9.7e-05 22.2 0.0 0.45 10.5 0.0 3.9 4 0 0 4 4 4 2 Domain of unknown function (DUF3437) MMS19_C PF12460.8 EWC47143.1 - 0.00027 20.2 0.4 9 5.3 0.1 4.9 5 1 1 6 6 6 0 RNAPII transcription regulator C-terminal UME PF08064.13 EWC47143.1 - 0.00028 20.8 0.0 0.66 9.9 0.0 4.1 4 1 0 4 4 4 1 UME (NUC010) domain RIX1 PF08167.12 EWC47143.1 - 0.00043 20.1 1.1 2.3 7.9 0.1 5.2 4 3 1 6 6 5 1 rRNA processing/ribosome biogenesis Arm PF00514.23 EWC47143.1 - 0.00096 19.1 2.8 0.7 10.0 0.0 4.9 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat TAF6_C PF07571.13 EWC47143.1 - 0.0011 19.3 0.0 14 6.1 0.0 5.1 4 1 1 5 5 5 0 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 EWC47143.1 - 0.0059 16.8 0.5 0.96 9.7 0.0 4.0 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF1981 PF09324.10 EWC47143.1 - 0.038 13.8 0.0 1.2 9.0 0.0 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF1981) DUF5578 PF17741.1 EWC47143.1 - 0.066 12.6 0.1 7.3 5.9 0.0 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5578) DUF3785 PF12653.7 EWC47143.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) HEAT_PBS PF03130.16 EWC47143.1 - 0.11 13.2 5.3 39 5.3 0.0 6.4 6 1 0 6 6 5 0 PBS lyase HEAT-like repeat Tti2 PF10521.9 EWC47143.1 - 0.33 10.5 1.2 6.5 6.2 0.2 3.5 2 2 1 4 4 4 0 Tti2 family Ribosomal_S8 PF00410.19 EWC47144.1 - 6.1e-22 77.9 0.0 9.8e-22 77.3 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 SNF2_N PF00176.23 EWC47145.1 - 1.4e-58 198.3 0.0 2.2e-58 197.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC47145.1 - 1.1e-15 58.0 0.0 2.3e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47145.1 - 7.8e-10 39.0 0.0 2.4e-09 37.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EWC47145.1 - 1.3e-06 27.8 0.0 2.9e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EWC47145.1 - 0.064 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 SWI2/SNF2 ATPase UvrD-helicase PF00580.21 EWC47146.1 - 4.6e-13 49.4 0.4 6.3e-07 29.2 0.0 2.7 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EWC47146.1 - 1.4e-11 44.9 0.0 6.3e-10 39.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain UvrD_C PF13361.6 EWC47146.1 - 1.5e-06 27.9 0.4 2.8e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 EWC47146.1 - 1.2e-05 25.0 0.0 3.6e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EWC47146.1 - 0.00013 21.8 0.6 0.83 9.3 0.1 3.3 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EWC47146.1 - 0.00049 19.9 0.0 0.0017 18.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EWC47146.1 - 0.00059 20.1 0.1 0.0027 18.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EWC47146.1 - 0.00081 19.4 0.0 0.0072 16.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_24 PF13479.6 EWC47146.1 - 0.004 16.9 0.0 0.0088 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EWC47146.1 - 0.031 13.7 0.1 0.21 11.0 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein DEAD PF00270.29 EWC47146.1 - 0.045 13.5 0.2 0.22 11.3 0.2 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase T2SSE PF00437.20 EWC47146.1 - 0.049 12.7 0.0 0.089 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 EWC47146.1 - 0.19 11.3 0.0 0.51 9.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Syja_N PF02383.18 EWC47147.1 - 2.3e-93 313.0 0.0 3.5e-93 312.4 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EWC47147.1 - 3.5e-39 133.1 0.0 8.9e-39 131.8 0.0 1.7 1 0 0 1 1 1 1 Inositol phosphatase AAA_2 PF07724.14 EWC47149.1 - 3.9e-52 176.8 1.0 1.2e-49 168.8 0.0 3.7 4 0 0 4 4 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EWC47149.1 - 1.8e-32 111.3 1.8 1.8e-32 111.3 1.8 3.5 3 0 0 3 3 3 1 AAA lid domain AAA PF00004.29 EWC47149.1 - 9.4e-29 100.5 0.0 8.1e-16 58.6 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EWC47149.1 - 9.5e-22 76.9 0.3 9.5e-22 76.9 0.3 2.9 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EWC47149.1 - 2.6e-17 63.1 0.1 3.7e-11 43.2 0.0 3.2 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EWC47149.1 - 3.1e-12 47.0 1.5 9.5e-05 22.7 0.0 4.5 2 2 2 4 4 3 2 AAA domain Sigma54_activat PF00158.26 EWC47149.1 - 4e-11 42.9 0.0 8.5e-07 28.8 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 EWC47149.1 - 4.8e-11 43.3 7.3 2.8e-06 27.8 0.1 5.0 3 2 0 4 4 3 2 AAA ATPase domain IstB_IS21 PF01695.17 EWC47149.1 - 1.6e-07 31.3 0.0 0.013 15.2 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 EWC47149.1 - 5.9e-07 29.1 0.3 0.018 14.4 0.2 3.5 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EWC47149.1 - 1.8e-06 28.0 0.0 0.096 12.7 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_7 PF12775.7 EWC47149.1 - 5e-06 26.1 0.0 0.0053 16.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region ATPase_2 PF01637.18 EWC47149.1 - 6.4e-06 26.3 0.2 1.3 8.9 0.1 4.3 3 1 0 3 3 3 2 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EWC47149.1 - 8.1e-06 26.1 0.0 0.041 14.0 0.0 3.2 2 1 0 2 2 2 2 AAA domain RuvB_N PF05496.12 EWC47149.1 - 1.3e-05 25.0 0.5 0.38 10.5 0.7 3.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EWC47149.1 - 1.8e-05 24.6 0.0 0.18 11.5 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EWC47149.1 - 2.3e-05 25.0 3.7 0.16 12.5 0.0 4.0 3 1 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 EWC47149.1 - 8.4e-05 22.9 0.0 0.3 11.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Torsin PF06309.11 EWC47149.1 - 0.00085 19.4 0.0 0.032 14.3 0.0 2.5 2 0 0 2 2 2 1 Torsin NACHT PF05729.12 EWC47149.1 - 0.00086 19.3 0.0 1.1 9.2 0.0 3.2 3 0 0 3 3 3 1 NACHT domain Sigma54_activ_2 PF14532.6 EWC47149.1 - 0.0011 19.1 0.1 1.4 9.1 0.0 3.4 3 1 0 3 3 2 1 Sigma-54 interaction domain AAA_28 PF13521.6 EWC47149.1 - 0.0017 18.6 1.9 3.3 7.9 0.0 3.8 4 1 1 5 5 3 1 AAA domain AAA_3 PF07726.11 EWC47149.1 - 0.002 18.0 0.1 2.9 7.8 0.1 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EWC47149.1 - 0.004 17.1 0.6 2.3 8.1 0.0 3.3 3 1 0 3 3 2 1 RsgA GTPase TsaE PF02367.17 EWC47149.1 - 0.0068 16.4 0.0 3.2 7.8 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 EWC47149.1 - 0.0068 16.6 0.0 3.7 7.8 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 EWC47149.1 - 0.007 16.0 0.1 4.6 6.8 0.0 3.2 2 0 0 2 2 2 0 AAA domain Clp_N PF02861.20 EWC47149.1 - 0.013 15.6 2.9 0.051 13.7 0.1 3.1 3 0 0 3 3 2 0 Clp amino terminal domain, pathogenicity island component ABC_tran PF00005.27 EWC47149.1 - 0.017 15.6 1.7 3.1 8.3 0.0 3.6 3 0 0 3 3 3 0 ABC transporter AAA_30 PF13604.6 EWC47149.1 - 0.029 14.1 0.0 11 5.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EWC47149.1 - 0.034 13.6 0.0 1.4 8.3 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 EWC47149.1 - 0.043 14.2 0.4 1.3 9.4 0.2 3.2 3 1 0 3 3 2 0 AAA domain AAA_8 PF12780.7 EWC47149.1 - 0.046 13.0 0.3 0.45 9.8 0.1 2.7 3 1 0 3 3 2 0 P-loop containing dynein motor region D4 FACT-Spt16_Nlob PF14826.6 EWC47149.1 - 0.047 13.5 0.0 1.8 8.4 0.0 3.0 3 0 0 3 3 3 0 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M16 PF00675.20 EWC47149.1 - 0.1 12.5 0.7 1.4 8.9 0.7 2.5 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) CbiA PF01656.23 EWC47149.1 - 0.14 12.2 0.0 18 5.4 0.0 3.4 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain V_ATPase_I PF01496.19 EWC47149.1 - 0.18 9.7 3.4 0.27 9.1 3.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cob_adeno_trans PF01923.18 EWC47149.1 - 0.42 10.7 4.3 1.9 8.6 1.1 3.3 3 1 1 4 4 3 0 Cobalamin adenosyltransferase APG6_N PF17675.1 EWC47149.1 - 0.73 10.4 14.4 3.7 8.1 14.4 2.3 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_23 PF13476.6 EWC47149.1 - 1.4 9.4 0.0 1.4 9.4 0.0 4.9 4 2 1 5 5 5 0 AAA domain OEP PF02321.18 EWC47149.1 - 3.5 7.4 7.3 11 5.8 7.3 1.8 1 0 0 1 1 1 0 Outer membrane efflux protein CENP-H PF05837.12 EWC47149.1 - 7.1 7.1 12.1 29 5.1 12.1 2.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DnaJ PF00226.31 EWC47150.1 - 4.1e-20 71.7 0.0 8.1e-20 70.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain CNDH2_C PF16858.5 EWC47150.1 - 0.0065 16.4 10.8 0.0092 15.9 10.8 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term PAP1 PF08601.10 EWC47150.1 - 0.06 13.1 9.6 0.076 12.7 9.6 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 PNISR PF15996.5 EWC47150.1 - 0.19 12.0 23.0 0.3 11.3 23.0 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4629 PF15442.6 EWC47150.1 - 0.22 11.7 13.6 0.048 13.9 9.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4629) Presenilin PF01080.17 EWC47150.1 - 0.25 10.1 12.1 0.3 9.8 12.1 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 EWC47150.1 - 0.58 9.1 4.6 0.74 8.7 4.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AAA_11 PF13086.6 EWC47150.1 - 0.84 9.4 7.4 1.2 8.9 7.4 1.2 1 0 0 1 1 1 0 AAA domain Peptidase_S64 PF08192.11 EWC47150.1 - 3.3 6.1 8.6 5.7 5.3 8.6 1.4 1 0 0 1 1 1 0 Peptidase family S64 Neur_chan_memb PF02932.16 EWC47150.1 - 3.8 7.5 4.4 4.8 7.2 4.4 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 EWC47150.1 - 4.9 6.4 8.0 6.5 6.0 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 EWC47150.1 - 6 5.0 16.8 7.5 4.7 16.8 1.2 1 0 0 1 1 1 0 CDC45-like protein LAP1C PF05609.12 EWC47150.1 - 6.4 5.8 12.5 8.5 5.3 12.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 EWC47150.1 - 7.7 3.5 8.6 8.8 3.3 8.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 EWC47150.1 - 9.6 5.1 8.5 14 4.6 8.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 IBR PF01485.21 EWC47152.1 - 5.1e-06 26.6 34.5 2e-05 24.7 9.2 4.7 4 1 0 4 4 4 3 IBR domain, a half RING-finger domain BiPBP_C PF06832.12 EWC47152.1 - 0.093 12.8 1.2 0.38 10.8 1.2 2.1 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family PTR2 PF00854.21 EWC47154.1 - 3.9e-77 259.7 12.6 5e-77 259.4 12.6 1.1 1 0 0 1 1 1 1 POT family Sugar_tr PF00083.24 EWC47154.1 - 0.0016 17.4 1.1 0.0016 17.4 1.1 3.1 4 0 0 4 4 4 2 Sugar (and other) transporter Sugarporin_N PF11471.8 EWC47154.1 - 0.081 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Glyco_hydro_16 PF00722.21 EWC47155.1 - 2e-10 40.4 0.0 5.3e-10 39.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 DUF2235 PF09994.9 EWC47156.1 - 4.2e-81 272.5 0.0 5.7e-81 272.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Collagen_mid PF15984.5 EWC47156.1 - 0.43 10.3 18.5 0.017 14.8 7.7 3.6 1 1 1 3 3 3 0 Bacterial collagen, middle region Chlorosome_CsmC PF11098.8 EWC47156.1 - 0.64 10.0 2.6 3.4 7.7 1.0 2.8 1 1 1 2 2 2 0 Chlorosome envelope protein C Helo_like_N PF17111.5 EWC47157.1 - 0.013 14.9 0.3 0.021 14.2 0.3 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Zn_clus PF00172.18 EWC47158.1 - 0.083 13.0 10.1 0.17 12.0 10.1 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain LprI PF07007.12 EWC47159.1 - 0.023 15.4 1.0 0.034 14.8 1.0 1.3 1 0 0 1 1 1 0 Lysozyme inhibitor LprI Citrate_synt PF00285.21 EWC47159.1 - 0.024 13.7 0.1 0.026 13.6 0.1 1.1 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain Mito_carr PF00153.27 EWC47160.1 - 2.8e-40 136.1 9.8 4.5e-17 61.8 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HTH_IclR PF09339.10 EWC47160.1 - 0.048 13.5 0.0 0.14 12.0 0.0 1.7 2 0 0 2 2 2 0 IclR helix-turn-helix domain 4HBT_3 PF13622.6 EWC47162.1 - 2.5e-69 234.3 0.2 2.5e-69 234.3 0.2 1.4 2 0 0 2 2 2 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EWC47162.1 - 8.2e-27 93.6 0.0 9e-23 80.6 0.0 2.4 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.22 EWC47162.1 - 0.014 15.7 0.1 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 Thioesterase superfamily HK PF02110.15 EWC47164.1 - 1.4e-74 250.6 2.3 1.9e-74 250.2 2.3 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EWC47164.1 - 4.6e-60 202.0 0.0 7e-60 201.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 EWC47164.1 - 0.0022 17.4 0.3 0.013 14.9 0.3 2.1 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EWC47164.1 - 0.022 14.1 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 pfkB family carbohydrate kinase Asp PF00026.23 EWC47165.1 - 2.2e-17 63.5 0.0 5.8e-17 62.1 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Herpes_gE PF02480.16 EWC47165.1 - 0.0062 15.3 0.1 0.011 14.5 0.1 1.3 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E TMEM154 PF15102.6 EWC47165.1 - 0.0093 15.9 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 TMEM154 protein family Mid2 PF04478.12 EWC47165.1 - 0.061 13.2 1.8 0.11 12.4 0.2 2.0 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Shisa PF13908.6 EWC47165.1 - 0.17 12.1 0.4 0.51 10.6 0.3 1.8 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Adeno_E3_CR2 PF02439.15 EWC47165.1 - 0.18 11.6 0.4 0.37 10.6 0.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 LapA_dom PF06305.11 EWC47165.1 - 0.22 11.4 2.3 0.17 11.7 0.2 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain UIM PF02809.20 EWC47165.1 - 7 6.8 6.7 1.3 9.1 1.3 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif Anp1 PF03452.14 EWC47166.1 - 1.5e-21 77.0 0.0 1.8e-12 47.3 0.0 2.2 2 0 0 2 2 2 2 Anp1 Amidohydro_2 PF04909.14 EWC47167.1 - 2.4e-21 76.8 2.6 3.8e-21 76.1 2.6 1.3 1 1 0 1 1 1 1 Amidohydrolase Phos_pyr_kin PF08543.12 EWC47168.1 - 8e-84 280.9 5.7 1.1e-83 280.4 5.7 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EWC47168.1 - 2.2e-40 138.7 0.2 3e-40 138.3 0.2 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 EWC47168.1 - 0.002 17.5 0.3 0.012 14.9 0.3 2.1 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Haem_oxygenas_2 PF14518.6 EWC47168.1 - 0.027 14.2 1.0 0.074 12.8 1.0 1.7 1 1 0 1 1 1 0 Iron-containing redox enzyme GYD PF08734.11 EWC47168.1 - 0.39 10.7 3.0 0.47 10.4 0.3 2.4 3 0 0 3 3 3 0 GYD domain Fungal_trans PF04082.18 EWC47169.1 - 2.6e-19 69.3 0.4 5.5e-19 68.2 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC47169.1 - 7.8e-07 29.1 8.5 7.8e-07 29.1 8.5 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GFO_IDH_MocA PF01408.22 EWC47171.1 - 8.6e-21 75.0 0.0 1.5e-20 74.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EWC47171.1 - 8.8e-07 28.9 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EWC47171.1 - 0.003 18.2 0.0 0.0059 17.3 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain EBP PF05241.12 EWC47172.1 - 1.1e-65 220.4 11.6 1.5e-65 220.0 11.6 1.1 1 0 0 1 1 1 1 Emopamil binding protein N2227 PF07942.12 EWC47173.1 - 9.1e-89 297.2 0.0 2.3e-88 295.9 0.0 1.6 1 1 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.12 EWC47173.1 - 0.034 14.9 0.0 0.32 11.8 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_23 PF13489.6 EWC47173.1 - 0.11 12.4 0.0 1.1 9.1 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EWC47173.1 - 0.2 12.4 0.0 1.4 9.6 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain PAP_central PF04928.17 EWC47174.1 - 1.3e-108 361.7 0.0 1.6e-108 361.4 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EWC47174.1 - 1.3e-47 161.6 0.0 2.5e-47 160.7 0.0 1.5 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EWC47174.1 - 6.1e-11 42.5 0.0 1.8e-10 41.0 0.0 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EWC47174.1 - 0.019 15.0 0.2 0.41 10.8 0.0 2.3 1 1 1 2 2 2 0 Polymerase beta, Nucleotidyltransferase MAGE PF01454.19 EWC47174.1 - 0.14 11.9 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 MAGE family FTR1 PF03239.14 EWC47178.1 - 2.3e-82 276.6 8.8 2.7e-82 276.4 8.8 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Cu-oxidase_2 PF07731.14 EWC47179.1 - 1e-45 154.8 2.6 5.4e-39 133.1 0.3 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EWC47179.1 - 1.2e-45 154.3 0.9 9.3e-41 138.6 0.1 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EWC47179.1 - 3.7e-38 131.1 0.5 2.3e-31 109.0 0.1 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EWC47179.1 - 0.00026 21.0 0.0 0.53 10.4 0.0 3.4 3 0 0 3 3 3 2 Cupredoxin-like domain PPC PF04151.15 EWC47179.1 - 0.068 14.3 0.0 1.4 10.0 0.0 2.8 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain DEAD PF00270.29 EWC47180.1 - 1.3e-35 122.8 0.0 2.2e-35 122.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC47180.1 - 4.9e-21 75.2 0.1 1.6e-20 73.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47180.1 - 1.9e-08 34.5 0.0 3.9e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 EWC47180.1 - 0.065 12.7 0.2 0.11 12.0 0.2 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain PIGA PF08288.12 EWC47181.1 - 2.3e-46 156.3 1.2 4.7e-45 152.1 0.1 2.3 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EWC47181.1 - 5.6e-28 98.1 0.1 9.5e-28 97.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EWC47181.1 - 2.5e-26 92.2 0.0 3.4e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EWC47181.1 - 2.8e-22 79.6 0.1 4.9e-22 78.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EWC47181.1 - 1.7e-14 54.6 0.0 2.8e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EWC47181.1 - 4.6e-06 26.7 0.0 7.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EWC47181.1 - 0.011 16.1 0.0 0.029 14.8 0.0 1.8 1 0 0 1 1 1 0 Glycosyl transferases group 1 AT_hook PF02178.19 EWC47182.1 - 0.79 9.8 6.4 1.9 8.7 5.0 2.3 2 0 0 2 2 2 0 AT hook motif DUF3413 PF11893.8 EWC47184.1 - 3.1 6.9 11.4 0.87 8.7 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3413) HMGL-like PF00682.19 EWC47185.1 - 1.9e-80 270.2 0.0 7.2e-80 268.3 0.0 1.8 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 EWC47185.1 - 3.7e-21 75.4 0.8 1.4e-20 73.5 0.8 1.9 1 1 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF2408 PF10303.9 EWC47187.1 - 1.4e-30 106.6 0.2 1e-25 90.8 0.0 3.1 2 1 1 3 3 3 2 Protein of unknown function (DUF2408) WXG100 PF06013.12 EWC47187.1 - 0.041 14.1 0.0 4.7 7.5 0.0 2.8 2 2 0 2 2 2 0 Proteins of 100 residues with WXG KELK PF15796.5 EWC47187.1 - 0.054 14.0 1.0 0.099 13.1 0.1 2.0 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FlaC_arch PF05377.11 EWC47187.1 - 0.098 13.1 0.1 8.9 6.8 0.0 3.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 EWC47187.1 - 0.14 11.0 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4208 PF13907.6 EWC47187.1 - 0.17 12.3 0.2 4.7 7.7 0.0 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4208) Pox_A_type_inc PF04508.12 EWC47187.1 - 1.9 8.4 6.7 5.2 7.1 1.5 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Ribosomal_60s PF00428.19 EWC47188.1 - 1.6e-16 60.6 16.3 1.6e-10 41.4 0.3 2.1 1 1 1 2 2 2 2 60s Acidic ribosomal protein Vert_HS_TF PF06546.11 EWC47188.1 - 0.05 13.3 0.1 0.06 13.0 0.1 1.0 1 0 0 1 1 1 0 Vertebrate heat shock transcription factor Pyr_redox_2 PF07992.14 EWC47189.1 - 3.3e-61 207.1 0.5 4.7e-61 206.6 0.5 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EWC47189.1 - 7e-33 113.2 0.2 1.3e-32 112.3 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EWC47189.1 - 1.4e-17 64.0 9.1 3.3e-15 56.4 0.1 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EWC47189.1 - 1.3e-14 54.2 1.0 2.1e-11 43.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EWC47189.1 - 3e-08 33.5 0.1 3.6e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EWC47189.1 - 1.7e-05 24.1 6.3 0.0014 17.8 2.9 3.1 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 EWC47189.1 - 3e-05 23.4 0.3 5.8e-05 22.4 0.3 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EWC47189.1 - 7.3e-05 22.9 1.4 0.00015 21.9 1.4 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EWC47189.1 - 0.00026 20.2 0.1 0.00095 18.4 0.0 1.8 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EWC47189.1 - 0.0012 17.6 1.2 0.023 13.4 0.5 2.5 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 EWC47189.1 - 0.004 16.8 3.4 0.009 15.6 3.4 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EWC47189.1 - 0.014 14.5 3.8 0.06 12.4 3.7 2.0 1 1 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EWC47189.1 - 0.026 13.6 0.5 0.075 12.1 0.5 1.7 1 1 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EWC47189.1 - 0.12 11.7 0.3 1.3 8.2 0.2 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EWC47189.1 - 5.9 6.7 7.3 2.3 8.1 0.0 2.7 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF5305 PF17231.2 EWC47190.1 - 0.0024 17.3 0.1 0.0034 16.8 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5305) DUF3040 PF11239.8 EWC47190.1 - 0.031 14.5 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Mid2 PF04478.12 EWC47190.1 - 0.056 13.3 0.8 0.091 12.6 0.2 1.7 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor MAP17 PF15807.5 EWC47190.1 - 0.11 12.7 0.5 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Asn_synthase PF00733.21 EWC47191.1 - 5.5e-95 319.0 0.1 6.8e-57 193.7 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EWC47191.1 - 4.3e-36 123.5 0.0 6.8e-36 122.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EWC47191.1 - 3.8e-29 101.6 0.0 6.6e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EWC47191.1 - 1.8e-07 30.9 0.0 3.3e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EWC47191.1 - 0.14 11.2 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Peptidase_M24 PF00557.24 EWC47192.1 - 2.2e-43 148.4 0.0 3e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Casc1 PF12366.8 EWC47192.1 - 0.04 13.4 0.4 0.064 12.8 0.4 1.2 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 PigN PF04987.14 EWC47193.1 - 8.6e-153 509.4 39.2 1.2e-152 508.9 39.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EWC47193.1 - 2.6e-10 40.4 5.3 2.4e-09 37.3 5.4 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EWC47193.1 - 1e-06 28.4 0.2 1.7e-06 27.7 0.2 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EWC47193.1 - 0.0042 16.5 0.1 0.0071 15.7 0.1 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily SWIRM PF04433.17 EWC47195.1 - 1.6e-08 34.7 0.0 5.1e-08 33.2 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.31 EWC47195.1 - 0.00015 21.9 0.0 0.0005 20.2 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-RING_11 PF17123.5 EWC47196.1 - 5.6e-08 32.4 5.9 9.3e-08 31.7 5.9 1.3 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EWC47196.1 - 1.8e-06 28.2 3.9 3e-06 27.5 3.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC47196.1 - 0.00016 21.5 2.9 0.00027 20.7 2.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC47196.1 - 0.00039 20.4 0.9 0.00072 19.5 0.9 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EWC47196.1 - 0.00046 20.1 0.9 0.00072 19.5 0.9 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EWC47196.1 - 0.0027 18.0 1.3 0.005 17.1 1.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EWC47196.1 - 0.051 13.5 3.2 0.081 12.8 3.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EWC47196.1 - 0.089 12.4 2.2 0.15 11.7 2.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 EWC47196.1 - 0.12 12.5 0.2 0.2 11.7 0.2 1.3 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 EWC47196.1 - 0.32 10.9 2.1 0.54 10.2 2.1 1.3 1 0 0 1 1 1 0 PHD-finger Fungal_trans_2 PF11951.8 EWC47197.1 - 5.8e-12 45.1 2.4 8.8e-12 44.5 2.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC47197.1 - 8.4e-08 32.2 7.6 1.7e-07 31.2 7.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 EWC47197.1 - 0.56 10.6 2.8 1.6 9.1 2.8 1.7 1 0 0 1 1 1 0 Opy2 protein adh_short PF00106.25 EWC47198.1 - 6.6e-81 270.4 10.0 2.3e-41 141.4 1.8 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC47198.1 - 3.2e-63 213.4 6.6 2.3e-32 112.5 0.6 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EWC47198.1 - 1.1e-31 108.9 0.0 2.3e-31 107.9 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EWC47198.1 - 6.2e-29 101.2 6.5 6.1e-14 52.3 0.5 2.5 2 1 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 EWC47198.1 - 0.001 18.4 2.8 0.0016 17.8 0.5 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PAS_3 PF08447.12 EWC47199.1 - 2.2e-17 63.1 0.0 5.3e-10 39.4 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 EWC47199.1 - 7.2e-12 45.3 0.0 0.00015 21.7 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EWC47199.1 - 2.4e-11 43.8 0.0 1.2e-05 25.4 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EWC47199.1 - 4.1e-09 36.7 0.0 0.00095 19.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EWC47199.1 - 5.8e-08 32.8 0.0 2.7e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_12 PF18095.1 EWC47199.1 - 0.1 12.2 0.0 5 6.8 0.0 2.2 2 0 0 2 2 2 0 UPF0242 C-terminal PAS-like domain Mit_ribos_Mrp51 PF11709.8 EWC47201.1 - 3.8e-75 253.8 0.7 8.8e-75 252.6 0.7 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit Pkinase PF00069.25 EWC47202.1 - 1.5e-70 237.6 0.0 1.9e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47202.1 - 1.5e-33 116.2 0.0 2e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EWC47202.1 - 1.9e-07 31.7 2.3 2.6e-07 31.2 0.5 2.2 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EWC47202.1 - 3.9e-06 26.1 0.0 5.9e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EWC47202.1 - 0.0035 16.7 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like CUE PF02845.16 EWC47203.1 - 0.0045 16.7 0.0 0.053 13.2 0.0 2.8 3 0 0 3 3 3 1 CUE domain Csm1 PF12539.8 EWC47204.1 - 9.1e-21 74.3 0.0 1.8e-20 73.3 0.0 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 Macoilin PF09726.9 EWC47204.1 - 0.019 13.6 4.5 0.021 13.4 4.5 1.1 1 0 0 1 1 1 0 Macoilin family Taxilin PF09728.9 EWC47204.1 - 0.027 13.7 7.6 0.039 13.1 7.6 1.2 1 0 0 1 1 1 0 Myosin-like coiled-coil protein CtIP_N PF10482.9 EWC47204.1 - 0.068 13.2 5.7 0.12 12.4 5.7 1.3 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Spc7 PF08317.11 EWC47204.1 - 0.078 11.8 8.4 0.15 10.9 8.4 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 EWC47204.1 - 0.094 11.8 9.8 0.15 11.1 9.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 EWC47204.1 - 0.26 10.7 12.2 0.68 9.4 11.8 1.8 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal MCM6_C PF18263.1 EWC47204.1 - 0.28 11.4 3.8 0.78 10.0 3.7 1.8 1 1 0 1 1 1 0 MCM6 C-terminal winged-helix domain CENP-F_leu_zip PF10473.9 EWC47204.1 - 0.29 11.2 11.7 0.11 12.5 2.6 2.2 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alpha-2-MRAP_C PF06401.11 EWC47204.1 - 0.48 10.4 9.3 4.9 7.1 7.3 2.2 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF2664 PF10867.8 EWC47204.1 - 0.54 10.7 5.5 0.59 10.6 4.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2664) GAS PF13851.6 EWC47204.1 - 0.96 8.8 13.2 3.3 7.0 13.2 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding GrpE PF01025.19 EWC47204.1 - 1.2 8.8 11.1 3.4 7.3 8.6 2.2 1 1 1 2 2 2 0 GrpE Fib_alpha PF08702.10 EWC47204.1 - 2.1 8.5 7.4 3.9 7.7 7.4 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 EWC47204.1 - 2.2 8.6 8.3 7.8 6.9 4.5 2.5 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0242 PF06785.11 EWC47204.1 - 8.7 6.4 13.3 8.2 6.5 12.0 1.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2 PF00096.26 EWC47205.1 - 2.3e-07 30.9 17.2 0.0027 18.1 1.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC47205.1 - 1.7e-06 28.2 17.1 8.8e-05 22.8 2.9 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC47205.1 - 0.00042 20.9 14.6 0.14 13.0 6.5 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EWC47205.1 - 0.69 10.6 4.4 0.52 11.0 1.0 2.5 1 1 1 2 2 2 0 FOXP coiled-coil domain Rad51 PF08423.11 EWC47206.1 - 8.3e-13 48.2 0.0 1.3e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EWC47206.1 - 1.7e-10 40.8 0.3 5.8e-10 39.1 0.1 1.9 2 0 0 2 2 2 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 EWC47206.1 - 8.5e-06 25.3 0.2 0.00023 20.6 0.0 2.1 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain ATPase PF06745.13 EWC47206.1 - 1.6e-05 24.4 0.0 3e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 EWC47206.1 - 8.9e-05 22.8 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EWC47206.1 - 0.00026 20.8 0.0 0.00047 19.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 EWC47206.1 - 0.0019 18.2 0.0 0.0042 17.0 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EWC47206.1 - 0.0023 17.6 0.6 0.0048 16.5 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EWC47206.1 - 0.0027 18.1 0.1 0.0057 17.1 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EWC47206.1 - 0.0032 17.9 0.0 0.0074 16.7 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.10 EWC47206.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 EWC47206.1 - 0.016 15.7 0.0 0.055 14.0 0.0 1.9 2 1 0 2 2 2 0 ABC transporter CbiA PF01656.23 EWC47206.1 - 0.017 15.2 0.0 0.029 14.4 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Rad17 PF03215.15 EWC47206.1 - 0.022 14.7 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 EWC47206.1 - 0.028 14.6 0.0 0.059 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EWC47206.1 - 0.036 14.6 0.0 0.066 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EWC47206.1 - 0.044 13.0 0.0 0.058 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EWC47206.1 - 0.064 13.0 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain C12orf66_like PF09404.10 EWC47206.1 - 0.091 11.6 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 KICSTOR complex C12orf66 like TIP49 PF06068.13 EWC47206.1 - 0.13 11.4 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_11 PF13086.6 EWC47206.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Xpo1 PF08389.12 EWC47207.1 - 1.9e-20 73.4 2.1 1.4e-19 70.6 0.4 3.1 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 EWC47207.1 - 1.6e-08 34.4 0.0 1.4e-06 28.1 0.0 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 EWC47207.1 - 0.00083 19.8 0.3 0.2 12.2 0.0 3.8 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.22 EWC47207.1 - 0.0084 16.3 0.0 7.9 7.0 0.0 4.4 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 EWC47207.1 - 0.0089 16.4 0.0 0.087 13.2 0.0 2.9 2 0 0 2 2 2 1 HEAT repeats Importin_rep_3 PF18806.1 EWC47207.1 - 0.14 12.2 0.0 2.5 8.2 0.0 2.8 3 0 0 3 3 3 0 Importin 13 repeat UME PF08064.13 EWC47207.1 - 0.15 11.9 0.1 42 4.1 0.0 3.4 3 0 0 3 3 3 0 UME (NUC010) domain 5-FTHF_cyc-lig PF01812.20 EWC47208.1 - 1e-43 149.3 0.0 1.2e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family HAUS6_N PF14661.6 EWC47209.1 - 5.8e-35 120.9 0.9 1e-34 120.1 0.9 1.4 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus HD_3 PF13023.6 EWC47210.1 - 1.1e-30 106.8 0.1 1.2e-30 106.6 0.1 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EWC47210.1 - 3.8e-06 26.8 0.1 5.1e-06 26.4 0.1 1.1 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EWC47210.1 - 0.00018 21.7 0.0 0.00038 20.7 0.0 1.6 1 0 0 1 1 1 1 HD domain MFS_1 PF07690.16 EWC47211.1 - 3.2e-20 72.4 7.0 3.2e-20 72.4 7.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily E1_DerP2_DerF2 PF02221.15 EWC47212.1 - 1.2e-19 71.1 0.1 1.6e-19 70.7 0.1 1.2 1 0 0 1 1 1 1 ML domain PHD PF00628.29 EWC47213.1 - 1.8e-08 34.1 8.7 3.4e-08 33.3 8.7 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 EWC47213.1 - 3.1e-05 24.4 0.0 0.00019 21.8 0.0 2.4 2 1 0 2 2 2 1 SET domain zf-CW PF07496.15 EWC47213.1 - 0.09 12.8 1.9 0.22 11.6 1.9 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger PHD_2 PF13831.6 EWC47213.1 - 0.47 10.0 3.7 0.87 9.2 3.7 1.4 1 0 0 1 1 1 0 PHD-finger Pox_A12 PF04651.13 EWC47213.1 - 8.2 6.4 13.9 7.9 6.5 6.4 2.7 2 0 0 2 2 2 0 Poxvirus A12 protein AMP-binding PF00501.28 EWC47214.1 - 1.8e-98 329.9 0.1 2.8e-98 329.3 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC47214.1 - 0.0012 19.8 0.0 0.0027 18.6 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Methyltransf_16 PF10294.9 EWC47215.1 - 1.3e-16 60.9 0.0 1.1e-08 35.0 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase CoA_transf_3 PF02515.17 EWC47216.1 - 4.8e-126 420.8 0.0 5.5e-126 420.6 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III zf-AN1 PF01428.16 EWC47219.1 - 9.9e-24 83.2 19.3 5.8e-12 45.6 7.9 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 EWC47219.1 - 0.0015 18.7 13.0 0.015 15.5 4.0 2.4 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 EWC47219.1 - 0.032 14.6 11.0 0.29 11.5 4.6 2.4 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain GH3 PF03321.13 EWC47219.1 - 0.043 12.7 0.2 0.061 12.2 0.2 1.1 1 0 0 1 1 1 0 GH3 auxin-responsive promoter zf-C5HC2 PF02928.16 EWC47219.1 - 0.046 14.1 7.6 1.5 9.3 1.2 2.5 2 0 0 2 2 2 0 C5HC2 zinc finger C1_4 PF07975.12 EWC47219.1 - 5.9 7.2 13.3 7.3 6.9 4.7 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain Cys_Met_Meta_PP PF01053.20 EWC47220.1 - 3.6e-138 460.3 0.0 4.2e-138 460.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EWC47220.1 - 6e-05 22.5 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EWC47220.1 - 0.00023 20.4 0.0 0.00036 19.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EWC47220.1 - 0.00028 20.0 0.0 0.00049 19.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V TQ PF18202.1 EWC47220.1 - 0.068 13.7 0.1 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 T-Q ester bond containing domain Kinesin PF00225.23 EWC47222.1 - 2.5e-64 217.3 0.0 4.1e-64 216.6 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EWC47222.1 - 5.9e-11 42.5 1.0 2.4e-08 34.1 0.0 2.9 3 0 0 3 3 3 2 Microtubule binding Stathmin PF00836.19 EWC47222.1 - 0.00026 21.0 7.7 0.00039 20.4 6.2 2.0 2 0 0 2 2 2 1 Stathmin family PhaC_N PF07167.13 EWC47222.1 - 0.012 15.3 0.1 0.051 13.2 0.0 2.0 2 0 0 2 2 2 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus DUF812 PF05667.11 EWC47222.1 - 0.059 12.3 12.0 0.088 11.7 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) CheB_methylest PF01339.17 EWC47222.1 - 0.084 12.6 0.1 0.35 10.6 0.1 2.0 1 1 0 1 1 1 0 CheB methylesterase DUF4472 PF14739.6 EWC47222.1 - 0.29 11.9 12.9 0.18 12.6 4.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) DivIC PF04977.15 EWC47222.1 - 1.8 8.4 6.0 12 5.7 0.2 2.5 2 0 0 2 2 2 0 Septum formation initiator WD40 PF00400.32 EWC47223.1 - 1.4e-15 57.4 0.9 3.3e-05 24.6 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47223.1 - 3.6e-10 40.0 0.3 0.007 16.7 0.1 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EWC47223.1 - 0.0063 15.5 0.0 5.9 5.7 0.0 3.6 4 0 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Hydin_ADK PF17213.3 EWC47223.1 - 0.034 14.4 2.4 0.062 13.6 2.4 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain VCBS PF13517.6 EWC47223.1 - 0.076 13.6 0.0 1.6 9.3 0.0 3.2 3 1 1 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Spt20 PF12090.8 EWC47223.1 - 0.3 10.7 10.4 0.43 10.2 10.4 1.1 1 0 0 1 1 1 0 Spt20 family Aconitase PF00330.20 EWC47225.1 - 9.3e-151 502.9 0.0 1.3e-150 502.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EWC47225.1 - 5.8e-42 143.1 0.0 1.9e-41 141.5 0.0 1.9 2 0 0 2 2 2 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 EWC47225.1 - 0.11 12.2 0.2 0.47 10.0 0.2 2.1 1 1 0 1 1 1 0 Aconitate hydratase 2 N-terminus SelP_N PF04592.14 EWC47225.1 - 6.9 6.0 21.2 12 5.2 21.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NDT80_PhoG PF05224.12 EWC47226.1 - 1.1e-38 133.3 0.0 1.8e-38 132.7 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Myelin_MBP PF01669.17 EWC47228.1 - 0.16 12.6 2.0 3.2 8.3 0.0 2.5 1 1 1 2 2 2 0 Myelin basic protein Pterin_bind PF00809.22 EWC47229.1 - 5e-81 272.0 0.1 8.3e-81 271.3 0.1 1.4 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EWC47229.1 - 6.3e-37 126.5 0.0 3.8e-36 124.0 0.0 2.3 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 EWC47229.1 - 5.1e-33 113.9 0.8 1.2e-21 77.3 0.1 3.5 2 1 1 3 3 3 3 Dihydroneopterin aldolase eIF3g PF12353.8 EWC47230.1 - 2.1e-43 147.7 1.2 3.2e-43 147.1 1.2 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EWC47230.1 - 9.7e-18 63.8 0.0 1.6e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EWC47230.1 - 0.017 15.2 1.1 2.4 8.3 0.0 3.0 3 0 0 3 3 3 0 RNA binding motif zf-CCCH_7 PF18586.1 EWC47230.1 - 0.025 14.9 0.2 0.056 13.8 0.2 1.5 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Nup35_RRM_2 PF14605.6 EWC47230.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif TackOD1 PF18551.1 EWC47230.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 NMO PF03060.15 EWC47231.1 - 1.2e-56 192.5 0.8 1.6e-56 192.1 0.8 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EWC47231.1 - 7.4e-11 41.6 1.1 1.9e-10 40.3 1.1 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EWC47231.1 - 3.6e-05 23.0 2.3 5.7e-05 22.3 2.3 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EWC47231.1 - 0.023 13.9 2.7 0.028 13.5 1.7 1.6 2 0 0 2 2 2 0 Conserved region in glutamate synthase DHO_dh PF01180.21 EWC47231.1 - 0.066 12.4 0.4 0.1 11.8 0.4 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase ArfGap PF01412.18 EWC47232.1 - 9.5e-35 119.2 0.0 2e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf UPF0128 PF03673.13 EWC47232.1 - 0.11 12.0 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Syntaxin-18_N PF10496.9 EWC47233.1 - 6.7e-13 48.7 1.2 2e-12 47.2 0.0 2.4 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus HA PF03457.14 EWC47233.1 - 0.1 13.0 1.2 0.96 9.8 0.4 2.7 2 1 0 2 2 2 0 Helicase associated domain DUF3886 PF13025.6 EWC47233.1 - 5 7.4 14.0 1.7 8.9 0.3 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3886) Glyco_hydro_47 PF01532.20 EWC47234.1 - 5e-131 437.8 0.1 5.7e-131 437.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SH3_1 PF00018.28 EWC47235.1 - 1.6e-20 72.5 0.0 4.7e-11 42.1 0.0 2.5 2 0 0 2 2 2 2 SH3 domain PX PF00787.24 EWC47235.1 - 3.4e-13 49.6 0.0 1.1e-12 47.9 0.0 1.9 2 0 0 2 2 2 1 PX domain SH3_9 PF14604.6 EWC47235.1 - 2.6e-12 46.4 0.0 1.6e-05 24.7 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EWC47235.1 - 2.7e-10 39.7 0.0 5.1e-07 29.3 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EWC47235.1 - 9e-05 22.3 0.3 0.0002 21.2 0.3 1.6 1 0 0 1 1 1 1 PB1 domain ChAPs PF09295.10 EWC47237.1 - 2.1e-154 514.3 0.0 3.2e-154 513.7 0.0 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_8 PF13181.6 EWC47237.1 - 3.7e-05 23.6 0.4 0.94 9.9 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC47237.1 - 0.00015 22.2 0.2 0.92 10.1 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47237.1 - 0.0041 16.9 1.2 4.9 7.1 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EWC47237.1 - 0.0058 15.9 0.4 0.58 9.3 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47237.1 - 0.006 16.6 1.9 12 6.3 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC47237.1 - 0.15 12.4 3.1 1.7 9.0 0.4 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47237.1 - 0.21 12.5 3.3 55 5.0 0.0 4.7 4 1 3 7 7 7 0 Tetratricopeptide repeat HSP70 PF00012.20 EWC47238.1 - 2.3e-263 874.8 12.2 2.7e-263 874.6 12.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EWC47238.1 - 7e-12 44.8 2.2 1.5e-10 40.4 0.9 2.6 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EWC47238.1 - 0.03 14.1 0.2 0.076 12.7 0.2 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Ploopntkinase3 PF18751.1 EWC47238.1 - 0.041 13.8 0.1 0.35 10.8 0.0 2.2 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Vps52 PF04129.12 EWC47238.1 - 0.13 11.0 0.3 0.2 10.4 0.3 1.2 1 0 0 1 1 1 0 Vps52 / Sac2 family DUF3213 PF11491.8 EWC47238.1 - 0.15 12.3 1.0 0.39 10.9 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3213) TSC22 PF01166.18 EWC47238.1 - 0.19 12.0 1.2 0.77 10.1 1.2 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family Med9 PF07544.13 EWC47238.1 - 0.48 10.5 3.8 1.2 9.3 1.5 2.7 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 YkyA PF10368.9 EWC47238.1 - 0.51 10.0 7.3 1.2 8.7 7.3 1.6 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein cwf21 PF08312.12 EWC47238.1 - 2 8.6 5.3 44 4.4 4.5 2.7 2 0 0 2 2 2 0 cwf21 domain YtxH PF12732.7 EWC47238.1 - 8.9 6.9 6.9 15 6.2 3.8 3.1 2 1 1 3 3 3 0 YtxH-like protein DUF2415 PF10313.9 EWC47239.1 - 4.1e-13 49.0 0.0 2.4e-12 46.6 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) ANAPC4_WD40 PF12894.7 EWC47239.1 - 0.0054 17.0 0.0 5.5 7.3 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EWC47239.1 - 1 10.3 6.0 28 5.8 0.4 5.2 6 1 0 6 6 6 0 WD domain, G-beta repeat SAC3_GANP PF03399.16 EWC47240.1 - 8.4e-26 91.0 0.3 9.7e-24 84.3 0.3 2.2 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EWC47240.1 - 2.1e-05 24.5 0.4 0.00022 21.2 0.0 2.6 3 1 0 3 3 3 1 CSN8/PSMD8/EIF3K family COX5A PF02284.16 EWC47240.1 - 0.083 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va Pkinase PF00069.25 EWC47241.1 - 2.3e-67 227.1 0.0 3e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47241.1 - 5.5e-30 104.5 0.0 7.7e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EWC47241.1 - 3e-13 50.2 0.9 3e-13 50.2 0.9 3.6 3 1 0 3 3 3 1 Protein kinase C terminal domain Kinase-like PF14531.6 EWC47241.1 - 5.2e-08 32.5 0.0 1.8e-07 30.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like C2 PF00168.30 EWC47241.1 - 2.3e-07 31.1 0.0 6.2e-05 23.2 0.0 2.6 2 0 0 2 2 2 1 C2 domain Haspin_kinase PF12330.8 EWC47241.1 - 0.0034 16.4 0.6 0.0034 16.4 0.6 1.8 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EWC47241.1 - 0.028 13.8 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Adeno_E3_15_3 PF03307.14 EWC47241.1 - 0.052 13.5 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region FTA2 PF13095.6 EWC47241.1 - 0.082 12.5 0.1 9.4 5.8 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EWC47241.1 - 0.089 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Glyco_transf_8 PF01501.20 EWC47245.1 - 0.002 17.8 0.1 0.0034 17.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EWC47245.1 - 0.06 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Mannosyltransferase putative Per1 PF04080.13 EWC47246.1 - 1e-82 277.8 13.9 3.1e-80 269.6 13.9 2.0 1 1 0 1 1 1 1 Per1-like family PGM_PMM_I PF02878.16 EWC47247.1 - 7e-16 58.2 0.0 1.6e-06 27.9 0.0 3.4 3 1 1 4 4 4 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EWC47247.1 - 3.8e-06 27.1 0.0 7.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EWC47247.1 - 0.0024 18.5 0.1 0.018 15.6 0.1 2.6 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Ldh_1_C PF02866.18 EWC47247.1 - 0.21 11.5 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain ApbA PF02558.16 EWC47248.1 - 1.6e-32 112.3 0.0 2.4e-32 111.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EWC47248.1 - 1.5e-27 96.3 0.0 8.3e-26 90.6 0.0 2.2 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal NAD_binding_7 PF13241.6 EWC47248.1 - 0.012 16.1 0.0 0.028 14.9 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EWC47248.1 - 0.019 14.2 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EWC47248.1 - 0.18 12.3 0.2 0.43 11.2 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase THDPS_N PF14790.6 EWC47248.1 - 0.2 11.5 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal FNIP_N PF14636.6 EWC47249.1 - 0.0066 17.4 0.7 0.011 16.7 0.1 1.7 1 1 1 2 2 2 1 Folliculin-interacting protein N-terminus DEAD PF00270.29 EWC47251.1 - 1.2e-15 57.8 0.0 2.5e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EWC47251.1 - 1.2e-09 38.4 0.2 5.6e-09 36.2 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EWC47251.1 - 1e-06 29.1 0.0 2.7e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.16 EWC47251.1 - 0.058 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Cyclin PF08613.11 EWC47252.1 - 2.4e-10 41.0 0.0 3.7e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EWC47252.1 - 9.5e-06 25.4 0.0 2.2e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain GMC_oxred_N PF00732.19 EWC47253.1 - 1.3e-53 182.3 0.0 1.7e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EWC47253.1 - 8.4e-37 126.9 0.1 1.3e-36 126.3 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EWC47253.1 - 6.9e-05 22.2 0.2 0.007 15.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EWC47253.1 - 0.00014 21.1 0.1 0.00026 20.1 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EWC47253.1 - 0.00031 20.9 0.0 0.00079 19.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EWC47253.1 - 0.00038 19.8 0.5 0.41 9.8 0.3 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC47253.1 - 0.0014 18.3 0.1 0.028 14.0 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EWC47253.1 - 0.0016 17.7 0.0 0.015 14.6 0.0 2.0 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 EWC47253.1 - 0.011 14.8 1.6 0.45 9.5 0.1 2.4 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EWC47253.1 - 0.024 13.7 0.3 0.17 10.9 0.1 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 EWC47253.1 - 0.21 11.5 0.5 3.5 7.6 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding CRC_subunit PF08624.10 EWC47254.1 - 4.2e-54 182.6 0.1 6.8e-54 182.0 0.1 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit TFIIB PF00382.19 EWC47255.1 - 1.2e-35 121.4 0.9 3.9e-19 68.5 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EWC47255.1 - 2.2e-30 105.0 3.2 2.2e-30 105.0 3.2 2.4 2 0 0 2 2 2 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 EWC47255.1 - 3e-06 27.0 0.6 0.0027 17.5 0.1 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain RB_B PF01857.20 EWC47255.1 - 0.0082 16.2 0.5 0.019 15.0 0.5 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain TF_Zn_Ribbon PF08271.12 EWC47255.1 - 0.0083 15.6 3.3 0.02 14.4 3.3 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Peptidase_M90 PF06167.12 EWC47256.1 - 0.076 12.6 0.4 0.61 9.6 0.4 2.1 1 1 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 F-box-like PF12937.7 EWC47257.1 - 2.7e-05 24.0 8.0 0.0026 17.6 0.4 2.6 3 0 0 3 3 3 2 F-box-like F-box PF00646.33 EWC47257.1 - 0.00019 21.2 0.5 0.079 12.9 0.0 2.5 2 0 0 2 2 2 2 F-box domain GNAT_acetyltr_2 PF13718.6 EWC47258.1 - 0.14 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF3294 PF07957.11 EWC47259.1 - 6.8e-07 29.3 0.2 2.3e-06 27.5 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3294) Fez1 PF06818.15 EWC47259.1 - 0.015 15.7 0.3 0.019 15.4 0.3 1.2 1 0 0 1 1 1 0 Fez1 betaPIX_CC PF16523.5 EWC47259.1 - 0.029 14.2 0.4 0.047 13.5 0.4 1.3 1 0 0 1 1 1 0 betaPIX coiled coil Reovirus_L2 PF06016.11 EWC47259.1 - 0.099 9.8 0.0 0.13 9.5 0.0 1.0 1 0 0 1 1 1 0 Reovirus core-spike protein lambda-2 (L2) Glyco_hydro_7 PF00840.20 EWC47260.1 - 8.4e-208 690.4 13.8 9.5e-208 690.2 13.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 AAA PF00004.29 EWC47261.1 - 3.1e-40 137.7 0.0 6.2e-40 136.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EWC47261.1 - 5.3e-19 67.9 0.2 1.1e-18 66.9 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EWC47261.1 - 1.4e-09 37.6 0.0 3.3e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EWC47261.1 - 6.3e-05 23.0 0.1 0.00033 20.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EWC47261.1 - 0.00017 22.0 2.9 0.016 15.6 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 EWC47261.1 - 0.00042 20.5 0.3 0.0027 17.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EWC47261.1 - 0.00047 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EWC47261.1 - 0.0031 17.8 2.3 0.11 12.7 0.0 3.0 2 1 1 3 3 3 1 AAA domain CLZ PF16526.5 EWC47261.1 - 0.0032 17.8 0.3 0.0099 16.2 0.3 1.9 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PhoH PF02562.16 EWC47261.1 - 0.0038 16.7 0.2 0.056 12.9 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 EWC47261.1 - 0.0056 16.1 0.1 0.016 14.6 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EWC47261.1 - 0.017 14.3 0.0 0.048 12.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EWC47261.1 - 0.023 14.9 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EWC47261.1 - 0.041 13.7 0.0 0.23 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EWC47261.1 - 0.05 13.3 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 EWC47261.1 - 0.1 12.3 0.0 0.32 10.7 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 EWC47261.1 - 0.12 12.1 0.1 0.33 10.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EWC47261.1 - 0.14 11.6 0.8 0.36 10.3 0.0 2.1 2 1 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EWC47261.1 - 0.19 12.1 0.0 1 9.8 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 EWC47261.1 - 0.23 11.0 0.9 2.1 7.9 0.1 2.3 1 1 1 2 2 2 0 AAA domain ERCC4 PF02732.15 EWC47262.1 - 1.1e-18 68.0 0.0 1.9e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 EWC47262.1 - 0.00016 21.9 0.0 0.00044 20.6 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain HTH_27 PF13463.6 EWC47262.1 - 0.12 12.9 0.1 20 5.8 0.0 3.4 3 0 0 3 3 3 0 Winged helix DNA-binding domain Brix PF04427.18 EWC47263.1 - 7.2e-45 153.5 0.0 1.1e-44 152.9 0.0 1.3 1 0 0 1 1 1 1 Brix domain Nop25 PF09805.9 EWC47263.1 - 2.8 8.4 21.6 5.6 7.4 21.6 1.5 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) zf-C2H2_6 PF13912.6 EWC47264.1 - 0.11 12.5 0.0 0.31 11.1 0.0 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EWC47264.1 - 0.17 12.4 19.5 1 9.9 0.3 5.0 4 1 0 4 4 4 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 EWC47264.1 - 0.84 10.3 6.6 1.4 9.6 0.1 3.6 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EWC47264.1 - 2.5 8.5 5.1 55 4.2 0.0 4.1 4 1 0 4 4 4 0 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 EWC47264.1 - 3.7 8.7 17.3 4 8.5 0.5 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger DEAD PF00270.29 EWC47265.1 - 2.4e-48 164.2 0.0 5.1e-48 163.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC47265.1 - 9e-30 103.3 0.0 2.4e-29 101.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47265.1 - 0.0014 18.7 0.1 0.0092 16.0 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Pico_P2B PF01552.17 EWC47265.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 Picornavirus 2B protein DUF305 PF03713.13 EWC47265.1 - 0.33 11.1 1.8 0.42 10.8 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF305) Peptidase_S24 PF00717.23 EWC47266.1 - 1e-09 38.2 0.0 2.9e-09 36.7 0.0 1.8 1 1 1 2 2 2 1 Peptidase S24-like ARGLU PF15346.6 EWC47267.1 - 0.015 15.2 8.5 0.015 15.2 8.5 2.0 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Dynein_light PF01221.18 EWC47267.1 - 0.097 13.0 1.9 0.19 12.1 1.9 1.4 1 0 0 1 1 1 0 Dynein light chain type 1 EnY2 PF10163.9 EWC47267.1 - 0.85 10.0 6.4 0.16 12.4 2.2 1.9 2 0 0 2 2 2 0 Transcription factor e(y)2 Lum_binding PF00677.17 EWC47269.1 - 2.2e-38 130.1 6.3 4.8e-19 68.1 1.2 2.8 2 1 0 2 2 2 2 Lumazine binding domain BTB PF00651.31 EWC47270.1 - 3.9e-05 23.8 0.0 0.00034 20.8 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Aldo_ket_red PF00248.21 EWC47273.1 - 3.3e-43 148.0 0.0 3.9e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Transthyretin PF00576.21 EWC47274.1 - 5.1e-36 123.7 0.0 5.8e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family CarboxypepD_reg PF13620.6 EWC47274.1 - 0.075 13.3 0.4 0.17 12.2 0.4 1.7 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Zn_clus PF00172.18 EWC47275.1 - 1e-08 35.1 9.3 2.1e-08 34.2 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EWC47275.1 - 0.00054 18.9 0.2 0.0009 18.1 0.2 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain RabGAP-TBC PF00566.18 EWC47277.1 - 2.7e-33 115.4 0.1 3.3e-32 111.9 0.1 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 EWC47279.1 - 3.4e-69 233.2 0.0 4.3e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47279.1 - 1.3e-34 119.7 0.0 1.8e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC47279.1 - 0.0034 16.8 0.0 0.0082 15.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EWC47279.1 - 0.025 13.3 0.2 0.07 11.9 0.0 1.7 3 0 0 3 3 3 0 Fungal protein kinase DUF4720 PF15846.5 EWC47280.1 - 0.025 14.4 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4720) BCS1_N PF08740.11 EWC47281.1 - 1.7e-42 145.5 1.6 2.3e-42 145.1 1.6 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EWC47281.1 - 6e-18 65.6 0.0 1.4e-17 64.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC47281.1 - 0.00011 22.7 0.0 0.00034 21.0 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EWC47281.1 - 0.0002 21.5 0.0 0.0015 18.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EWC47281.1 - 0.0011 18.2 0.0 0.0018 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 EWC47281.1 - 0.005 17.4 0.0 0.0091 16.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EWC47281.1 - 0.0052 17.3 0.0 0.011 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EWC47281.1 - 0.0076 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EWC47281.1 - 0.012 15.8 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EWC47281.1 - 0.018 15.1 0.0 0.054 13.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EWC47281.1 - 0.039 14.3 0.0 0.084 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Cytidylate_kin PF02224.18 EWC47281.1 - 0.048 13.4 0.0 0.093 12.5 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase Viral_helicase1 PF01443.18 EWC47281.1 - 0.053 13.2 0.1 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EWC47281.1 - 0.059 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 EWC47281.1 - 0.079 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EWC47281.1 - 0.15 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain PPV_E1_C PF00519.17 EWC47281.1 - 0.22 10.3 0.0 0.33 9.7 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase UQ_con PF00179.26 EWC47282.1 - 5.9e-43 145.9 0.0 6.6e-43 145.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EWC47282.1 - 0.00038 20.2 0.0 0.00043 20.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EWC47282.1 - 0.055 13.8 0.0 0.061 13.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain LRR_6 PF13516.6 EWC47283.1 - 1.4e-05 24.8 6.0 0.49 10.6 0.1 6.3 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 EWC47283.1 - 0.044 14.2 12.6 1.4 9.4 0.2 4.7 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EWC47283.1 - 2.1 8.2 8.8 12 5.8 0.3 4.1 4 1 0 4 4 4 0 Leucine rich repeat SUR7 PF06687.12 EWC47284.1 - 0.022 14.4 0.0 0.022 14.4 0.0 2.6 3 0 0 3 3 3 0 SUR7/PalI family TMEM171 PF15471.6 EWC47284.1 - 3 6.7 6.2 22 3.9 0.0 2.3 2 0 0 2 2 2 0 Transmembrane protein family 171 Mucin PF01456.17 EWC47284.1 - 8.6 6.3 12.6 0.34 10.9 6.7 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein PPR_2 PF13041.6 EWC47285.1 - 0.016 15.4 0.0 0.3 11.3 0.0 3.0 3 0 0 3 3 3 0 PPR repeat family Pox_Ag35 PF03286.14 EWC47285.1 - 0.8 9.5 3.8 2 8.2 3.8 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SOG2 PF10428.9 EWC47286.1 - 0.0012 18.1 1.4 0.0013 18.0 1.4 1.0 1 0 0 1 1 1 1 RAM signalling pathway protein SKG6 PF08693.10 EWC47286.1 - 0.011 15.1 2.1 0.02 14.3 2.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Amnionless PF14828.6 EWC47286.1 - 0.1 11.4 0.0 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Amnionless EphA2_TM PF14575.6 EWC47286.1 - 0.15 13.0 0.0 0.3 12.0 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TALPID3 PF15324.6 EWC47286.1 - 0.69 7.5 10.3 0.88 7.2 10.3 1.1 1 0 0 1 1 1 0 Hedgehog signalling target DUF3433 PF11915.8 EWC47287.1 - 2.1e-42 143.5 2.7 7.8e-22 77.5 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) UPF0139 PF03669.13 EWC47287.1 - 0.022 14.6 0.1 0.38 10.6 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) zf-PARP PF00645.18 EWC47288.1 - 4.1e-19 69.2 0.1 1.7e-18 67.2 0.1 2.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GPI-anchored PF10342.9 EWC47289.1 - 1.3e-18 67.5 5.4 1.7e-17 63.9 0.0 2.4 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family ATS PF15445.6 EWC47289.1 - 0.018 14.5 2.4 0.025 14.0 2.4 1.3 1 1 0 1 1 1 0 acidic terminal segments, variant surface antigen of PfEMP1 Aldo_ket_red PF00248.21 EWC47290.1 - 1.1e-30 106.9 0.0 1.5e-21 76.9 0.0 2.4 1 1 1 2 2 2 2 Aldo/keto reductase family Dev_Cell_Death PF10539.9 EWC47290.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Development and cell death domain Pkinase_Tyr PF07714.17 EWC47291.1 - 3.2e-22 79.1 0.0 5.7e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EWC47291.1 - 5.4e-21 75.1 0.0 9.7e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPR_12 PF13424.6 EWC47291.1 - 1.9e-14 53.7 12.5 2.7e-05 24.4 0.1 6.9 4 1 3 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 EWC47291.1 - 2.6e-09 36.7 5.0 0.17 11.8 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat Kdo PF06293.14 EWC47291.1 - 0.0027 17.1 0.0 0.0075 15.6 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Snapin_Pallidin PF14712.6 EWC47291.1 - 0.036 14.5 8.0 1.9 9.0 0.1 3.9 3 0 0 3 3 3 0 Snapin/Pallidin TPR_2 PF07719.17 EWC47291.1 - 0.071 13.2 0.9 15 6.0 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Pox_ser-thr_kin PF05445.11 EWC47291.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MetOD2 PF18548.1 EWC47291.1 - 1.3 9.2 3.6 3.8 7.7 0.7 2.9 2 0 0 2 2 2 0 Metanogen output domain 2 Pkinase PF00069.25 EWC47292.1 - 1.5e-29 103.2 0.0 2.8e-27 95.8 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47292.1 - 1.1e-22 80.6 0.0 2.5e-21 76.2 0.0 3.1 2 2 0 2 2 2 1 Protein tyrosine kinase oligo_HPY PF08352.12 EWC47293.1 - 0.038 14.5 0.3 0.26 11.8 0.1 2.4 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region GIT_CC PF16559.5 EWC47293.1 - 0.47 10.4 3.3 0.89 9.5 3.3 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc24 PF08286.11 EWC47293.1 - 4.3 7.6 5.4 0.41 10.9 0.5 1.8 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DSPc PF00782.20 EWC47295.1 - 0.00039 20.2 0.0 0.00091 19.0 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EWC47295.1 - 0.085 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Fungal_trans PF04082.18 EWC47298.1 - 2.9e-22 79.0 1.7 4.4e-22 78.4 1.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC47298.1 - 8e-08 32.3 6.8 1.5e-07 31.4 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_10 PF16588.5 EWC47298.1 - 0.077 12.7 2.0 0.24 11.1 2.0 1.8 1 0 0 1 1 1 0 C2H2 zinc-finger FAD_binding_4 PF01565.23 EWC47300.1 - 1.5e-21 76.6 2.3 2.8e-21 75.7 2.3 1.5 1 0 0 1 1 1 1 FAD binding domain APH PF01636.23 EWC47301.1 - 3.7e-11 43.4 0.1 5.3e-11 42.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EWC47301.1 - 1.7e-05 24.3 0.0 3.8e-05 23.2 0.0 1.5 2 0 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 EWC47301.1 - 0.0012 17.7 0.0 0.0018 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) DsbG_N PF18257.1 EWC47302.1 - 0.063 13.4 0.0 6.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Disulfide isomerase DsbG N-terminal AA_permease_2 PF13520.6 EWC47303.1 - 7.1e-63 212.9 52.2 9.1e-63 212.5 52.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC47303.1 - 6.5e-23 81.1 45.2 8.3e-23 80.7 45.2 1.1 1 0 0 1 1 1 1 Amino acid permease Fungal_lectin PF07938.12 EWC47304.1 - 3.7e-13 49.6 2.0 1.6e-06 27.8 1.2 3.0 2 1 0 2 2 2 2 Fungal fucose-specific lectin Methyltransf_23 PF13489.6 EWC47305.1 - 3.7e-19 69.2 0.0 5.6e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC47305.1 - 5.8e-11 42.9 0.0 2.3e-10 41.1 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC47305.1 - 3e-08 34.3 0.0 1.2e-06 29.1 0.0 3.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC47305.1 - 1.5e-07 31.9 0.0 7.9e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC47305.1 - 2.1e-07 30.8 0.0 0.0054 16.5 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain MTS PF05175.14 EWC47305.1 - 0.00067 19.2 0.0 0.0089 15.6 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EWC47305.1 - 0.004 16.5 0.0 0.0069 15.7 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 EWC47305.1 - 0.0049 16.2 0.0 0.07 12.4 0.0 2.3 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EWC47305.1 - 0.014 14.7 0.0 1.1 8.6 0.0 2.7 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EWC47305.1 - 0.022 14.2 0.0 0.049 13.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EWC47305.1 - 0.023 14.2 0.0 0.058 12.9 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase IPPT PF01715.17 EWC47305.1 - 0.036 13.9 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 IPP transferase FtsJ PF01728.19 EWC47305.1 - 0.057 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 EWC47305.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 EWC47305.1 - 0.17 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Zn_clus PF00172.18 EWC47306.1 - 3.7e-07 30.2 8.8 6.7e-07 29.3 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EWC47306.1 - 0.00023 20.3 1.0 0.00023 20.3 1.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain TPR_12 PF13424.6 EWC47306.1 - 0.0019 18.5 0.0 0.0039 17.5 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat Sugar_tr PF00083.24 EWC47307.1 - 5.5e-92 309.0 16.0 6.3e-92 308.8 16.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC47307.1 - 4.9e-36 124.4 31.3 1.4e-25 90.0 15.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EWC47307.1 - 0.021 13.2 3.5 0.35 9.2 0.2 2.3 2 0 0 2 2 2 0 Transmembrane secretion effector TRI12 PF06609.13 EWC47307.1 - 0.031 12.7 12.0 0.36 9.2 3.5 2.3 1 1 1 2 2 2 0 Fungal trichothecene efflux pump (TRI12) DUF3792 PF12670.7 EWC47307.1 - 3.6 7.8 19.2 0.75 10.0 2.7 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF3792) AA_permease PF00324.21 EWC47308.1 - 4e-120 401.6 36.8 4.8e-120 401.4 36.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EWC47308.1 - 6.8e-34 117.4 39.2 9.7e-34 116.9 39.2 1.2 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EWC47308.1 - 0.052 12.3 0.1 0.092 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) MFS_1 PF07690.16 EWC47309.1 - 7.1e-39 133.7 43.6 6.2e-37 127.3 43.6 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sulfatase PF00884.23 EWC47310.1 - 2.1e-45 155.4 0.5 1.7e-44 152.5 0.0 2.1 1 1 1 2 2 2 1 Sulfatase DUF4976 PF16347.5 EWC47310.1 - 0.052 13.8 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) DUF229 PF02995.17 EWC47310.1 - 0.13 10.8 0.0 0.21 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF1501 PF07394.12 EWC47310.1 - 0.22 10.6 0.1 0.47 9.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) MFS_1 PF07690.16 EWC47312.1 - 5e-37 127.6 41.4 2.1e-36 125.6 40.4 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC47312.1 - 8.2e-13 48.0 24.3 9.3e-12 44.5 10.7 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter ACP_syn_III_C PF08541.10 EWC47312.1 - 0.49 10.6 2.5 0.71 10.1 0.0 2.4 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Tim17 PF02466.19 EWC47312.1 - 0.52 10.7 4.3 2.5 8.5 4.3 2.1 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family YSIRK_signal PF04650.17 EWC47312.1 - 1.8 8.5 4.9 4.7 7.2 4.9 1.8 1 0 0 1 1 1 0 YSIRK type signal peptide Peptidase_M14 PF00246.24 EWC47313.1 - 5.3e-77 259.5 0.1 6.3e-77 259.2 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EWC47313.1 - 1.5e-11 44.5 0.1 3.4e-11 43.4 0.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide p450 PF00067.22 EWC47314.1 - 1.9e-81 274.2 0.0 3.1e-81 273.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EWC47314.1 - 1.7e-24 86.7 0.0 3.4e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EWC47314.1 - 2.8e-23 82.7 0.0 5.4e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EWC47314.1 - 8.9e-13 48.8 0.0 6.1e-12 46.1 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EWC47314.1 - 0.033 14.5 0.0 0.18 12.1 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain Glyoxalase PF00903.25 EWC47316.1 - 2.1e-30 105.6 0.1 8.5e-17 61.5 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EWC47316.1 - 8.6e-12 45.3 0.0 5.3e-07 29.9 0.0 3.3 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EWC47316.1 - 0.004 17.3 0.0 0.08 13.0 0.0 2.7 2 1 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EWC47316.1 - 0.0074 16.2 0.4 7.7 6.5 0.0 3.7 3 1 0 3 3 3 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EWC47316.1 - 0.098 13.5 0.0 1.4 9.8 0.0 2.6 2 2 0 2 2 2 0 Glyoxalase-like domain MG4 PF17789.1 EWC47316.1 - 0.14 12.4 0.0 25 5.1 0.0 2.9 2 1 1 3 3 3 0 Macroglobulin domain MG4 Annexin PF00191.20 EWC47317.1 - 2.9e-50 168.2 1.6 8e-13 48.3 0.0 4.3 4 1 0 4 4 4 4 Annexin DUF3574 PF12098.8 EWC47317.1 - 0.081 12.7 0.0 16 5.4 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3574) Tim17 PF02466.19 EWC47320.1 - 1.5e-26 93.0 3.9 2e-26 92.5 3.9 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2428 PF10350.9 EWC47321.1 - 1.3e-54 185.3 0.0 2.4e-54 184.5 0.0 1.5 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) Cnd1 PF12717.7 EWC47321.1 - 0.048 13.7 0.0 0.24 11.4 0.0 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EWC47321.1 - 0.42 11.0 1.5 39 4.9 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat V-ATPase_H_N PF03224.14 EWC47322.1 - 0.092 12.0 0.7 0.13 11.6 0.7 1.3 1 1 0 1 1 1 0 V-ATPase subunit H Sedlin_N PF04628.13 EWC47324.1 - 4.4e-45 153.0 0.0 4.9e-45 152.9 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EWC47324.1 - 8.6e-10 38.7 0.1 1.3e-09 38.1 0.1 1.3 1 1 0 1 1 1 1 Sybindin-like family NDUF_B6 PF09782.9 EWC47324.1 - 0.13 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit COX7a PF02238.15 EWC47325.1 - 9.3e-24 83.6 0.5 1.1e-23 83.3 0.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII B12D PF06522.11 EWC47325.1 - 0.15 11.8 2.8 1.9 8.3 0.4 2.1 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF1682 PF07946.14 EWC47326.1 - 3.9e-98 328.6 1.3 4.6e-98 328.4 1.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) tRNA-synt_1d PF00750.19 EWC47327.1 - 5.4e-108 361.0 2.9 7.1e-108 360.6 2.9 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EWC47327.1 - 1.3e-29 102.8 0.2 2.9e-29 101.7 0.2 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EWC47327.1 - 0.00018 22.0 0.0 0.00068 20.2 0.0 2.1 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain Thiamine_BP PF01910.17 EWC47328.1 - 1e-14 54.2 0.0 1.3e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Thiamine-binding protein CBM_1 PF00734.18 EWC47329.1 - 6.7e-15 54.8 7.9 1e-14 54.1 7.9 1.3 1 0 0 1 1 1 1 Fungal cellulose binding domain YARHG PF13308.6 EWC47330.1 - 0.021 14.7 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 YARHG domain EI24 PF07264.11 EWC47332.1 - 1.7e-12 48.0 11.3 2.1e-12 47.6 11.3 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF2417 PF10329.9 EWC47332.1 - 0.3 10.5 5.0 0.1 12.0 1.7 1.8 2 1 0 2 2 2 0 Region of unknown function (DUF2417) Ion_trans_2 PF07885.16 EWC47333.1 - 8.8e-26 89.7 25.0 8.9e-15 54.4 5.1 3.1 3 0 0 3 3 3 2 Ion channel DUF2207 PF09972.9 EWC47333.1 - 0.55 8.9 9.1 3.3 6.3 0.1 3.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) zf-primase PF09329.11 EWC47334.1 - 2.1e-20 72.2 2.1 3.5e-20 71.5 2.1 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.25 EWC47334.1 - 0.00089 19.2 0.0 0.0022 18.0 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RNase_T PF00929.24 EWC47335.1 - 4.2e-26 92.4 0.0 5.3e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Ribosomal_L9_N PF01281.19 EWC47336.1 - 1.2e-09 37.5 0.0 2.3e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 EWC47336.1 - 0.00024 21.5 3.3 0.0003 21.2 0.7 2.4 2 1 0 2 2 2 1 Ribosomal protein L9, C-terminal domain F_bP_aldolase PF01116.20 EWC47337.1 - 3.6e-93 312.1 0.0 4.1e-93 311.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Peptidase_C26 PF07722.13 EWC47337.1 - 0.075 12.8 0.0 3 7.5 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 RSN1_7TM PF02714.15 EWC47338.1 - 2.7e-71 240.1 22.5 2.7e-71 240.1 22.5 2.1 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EWC47338.1 - 9.4e-35 120.4 0.0 1.8e-34 119.5 0.0 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EWC47338.1 - 4e-33 114.4 1.6 4e-33 114.4 1.6 2.7 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport PGM_PMM_I PF02878.16 EWC47339.1 - 5.8e-30 103.8 0.0 9.2e-30 103.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EWC47339.1 - 5.5e-24 84.6 0.0 9.2e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EWC47339.1 - 2.8e-13 50.4 0.0 5.6e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EWC47339.1 - 0.00033 20.8 0.0 0.00077 19.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Oxysterol_BP PF01237.18 EWC47340.1 - 5.2e-67 226.3 0.1 6e-65 219.5 0.1 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein UCH PF00443.29 EWC47341.1 - 2.3e-35 122.3 0.0 1.1e-30 107.0 0.0 2.3 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EWC47341.1 - 8e-05 22.4 5.4 0.0048 16.5 5.4 2.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase FSA_C PF10479.9 EWC47341.1 - 0.32 9.1 5.9 0.45 8.6 5.9 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SurE PF01975.17 EWC47343.1 - 1.6e-49 168.4 0.0 2.3e-49 167.9 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE TTL PF03133.15 EWC47343.1 - 4.3e-47 160.7 0.0 6.3e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family PAP1 PF08601.10 EWC47344.1 - 0.57 9.9 6.0 0.67 9.6 6.0 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Cyt-b5 PF00173.28 EWC47345.1 - 4.7e-12 45.9 0.0 5.4e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain LtuB PF17455.2 EWC47346.1 - 0.063 13.9 0.3 0.14 12.8 0.3 1.5 1 0 0 1 1 1 0 Late transcription unit B Seipin PF06775.14 EWC47347.1 - 1.4e-53 181.9 0.5 1.8e-53 181.6 0.5 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Asp5 PF17000.5 EWC47347.1 - 0.098 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Accessory secretory protein Sec, Asp5 Pex14_N PF04695.13 EWC47348.1 - 6.8e-29 101.6 14.3 1.3e-28 100.6 0.1 3.9 2 2 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3584 PF12128.8 EWC47348.1 - 0.00042 18.0 9.7 0.00053 17.7 9.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) zf-C4H2 PF10146.9 EWC47348.1 - 0.003 17.9 0.1 0.0043 17.4 0.1 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein Golgin_A5 PF09787.9 EWC47348.1 - 0.044 13.2 4.8 0.059 12.8 4.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 XRN_M PF17846.1 EWC47348.1 - 0.066 12.2 0.3 0.084 11.8 0.3 1.1 1 0 0 1 1 1 0 Xrn1 helical domain GAS PF13851.6 EWC47348.1 - 0.091 12.1 8.1 0.16 11.3 8.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Herpes_UL25 PF01499.16 EWC47348.1 - 0.094 11.2 3.5 0.15 10.6 3.5 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family Prominin PF05478.11 EWC47348.1 - 0.099 10.6 0.4 0.13 10.2 0.4 1.1 1 0 0 1 1 1 0 Prominin DCB PF16213.5 EWC47348.1 - 0.13 11.9 2.0 0.23 11.1 2.0 1.4 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 IL4 PF00727.18 EWC47348.1 - 0.18 12.1 1.5 0.3 11.3 1.5 1.3 1 0 0 1 1 1 0 Interleukin 4 Spc7 PF08317.11 EWC47348.1 - 0.22 10.4 8.2 0.31 9.9 8.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 EWC47348.1 - 0.25 11.6 8.6 0.4 10.9 8.6 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 SMBP PF16785.5 EWC47348.1 - 0.28 11.4 3.9 0.73 10.1 3.9 1.7 1 0 0 1 1 1 0 Small metal-binding protein FUSC PF04632.12 EWC47348.1 - 0.34 9.4 4.7 0.48 8.9 4.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family LMBR1 PF04791.16 EWC47348.1 - 0.42 9.5 0.3 0.51 9.2 0.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 EWC47348.1 - 0.47 9.7 6.2 0.82 9.0 6.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF848 PF05852.11 EWC47348.1 - 0.66 10.1 5.8 1.1 9.4 5.8 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Baculo_PEP_C PF04513.12 EWC47348.1 - 0.85 9.7 4.5 3.2 7.8 0.6 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Muted PF14942.6 EWC47348.1 - 1.1 9.6 6.8 1.9 8.8 0.6 2.0 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein FlgN PF05130.12 EWC47348.1 - 1.2 9.7 9.0 2 8.9 9.0 1.3 1 0 0 1 1 1 0 FlgN protein TMPIT PF07851.13 EWC47348.1 - 1.5 8.0 3.9 2.2 7.5 3.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein ERM PF00769.19 EWC47348.1 - 2.6 7.8 14.1 8.1 6.2 14.1 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Cyclin_N PF00134.23 EWC47349.1 - 2.1e-16 59.8 1.0 1.3e-15 57.2 0.5 2.3 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EWC47349.1 - 1.3e-05 25.3 0.0 0.0015 18.6 0.0 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EWC47349.1 - 0.021 14.9 0.6 0.89 9.7 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Sucrose_synth PF00862.19 EWC47349.1 - 0.028 12.8 0.1 0.039 12.3 0.1 1.1 1 0 0 1 1 1 0 Sucrose synthase RcsC PF09456.10 EWC47349.1 - 0.035 14.1 0.1 0.081 12.9 0.1 1.6 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) Cyclin_C_2 PF16899.5 EWC47349.1 - 0.035 14.5 0.0 0.19 12.1 0.0 2.2 3 0 0 3 3 3 0 Cyclin C-terminal domain adh_short PF00106.25 EWC47351.1 - 3.2e-45 154.0 3.5 4.3e-45 153.6 3.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC47351.1 - 3.6e-45 154.3 4.2 4.9e-45 153.9 4.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC47351.1 - 1.1e-15 58.0 0.9 1.4e-15 57.7 0.9 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EWC47351.1 - 0.00039 20.3 0.8 0.00057 19.8 0.8 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EWC47351.1 - 0.0026 17.9 0.7 0.0055 16.8 0.7 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EWC47351.1 - 0.099 12.2 0.2 0.18 11.4 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MRP-L28 PF09812.9 EWC47352.1 - 2.9e-17 63.3 2.0 4.5e-17 62.6 2.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Vps35 PF03635.17 EWC47353.1 - 8.3e-299 993.3 12.8 1.1e-297 989.5 12.8 1.9 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 V-ATPase_H_C PF11698.8 EWC47353.1 - 0.056 13.6 0.0 0.5 10.5 0.0 2.7 2 0 0 2 2 2 0 V-ATPase subunit H AA_permease_2 PF13520.6 EWC47354.1 - 2.7e-58 197.8 57.2 3.6e-58 197.4 57.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC47354.1 - 3.4e-15 55.6 51.9 5.5e-15 54.9 51.9 1.3 1 1 0 1 1 1 1 Amino acid permease AnkUBD PF18418.1 EWC47354.1 - 0.12 12.5 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 Ankyrin ubiquitin-binding domain TPR_12 PF13424.6 EWC47356.1 - 0.00019 21.7 0.0 0.14 12.5 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat GLTSCR1 PF15249.6 EWC47356.1 - 0.03 14.8 0.1 0.11 12.9 0.1 1.9 1 0 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein DUF3907 PF13047.6 EWC47356.1 - 0.048 13.6 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) DUF5344 PF17279.2 EWC47356.1 - 0.066 13.8 0.1 0.24 12.0 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5344) TPR_10 PF13374.6 EWC47356.1 - 0.068 13.1 1.0 2.2 8.2 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EWC47356.1 - 0.25 11.4 5.1 3.1 8.1 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47356.1 - 2.6 8.4 5.0 60 4.1 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Methyltransf_3 PF01596.17 EWC47357.1 - 1.6e-49 168.0 0.1 1.8e-49 167.8 0.1 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EWC47357.1 - 3.7e-15 56.9 0.0 8.6e-15 55.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC47357.1 - 1.2e-07 31.6 0.1 2.1e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC47357.1 - 1.2e-06 29.1 0.1 2.7e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC47357.1 - 0.00042 20.9 0.4 0.0021 18.6 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC47357.1 - 0.0011 19.6 0.1 0.003 18.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 EWC47357.1 - 0.0025 17.4 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 EWC47357.1 - 0.0029 17.4 0.0 0.0038 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CmcI PF04989.12 EWC47357.1 - 0.0081 15.9 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_16 PF10294.9 EWC47357.1 - 0.0087 15.8 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EWC47357.1 - 0.038 13.5 0.0 0.054 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain CheR PF01739.18 EWC47357.1 - 0.057 12.9 0.0 0.099 12.1 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain DUF3292 PF11696.8 EWC47358.1 - 1.7e-06 26.7 2.7 0.12 10.8 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF3292) PRT_C PF08372.10 EWC47358.1 - 0.022 14.5 1.3 0.036 13.8 0.0 1.9 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal GWT1 PF06423.12 EWC47358.1 - 0.12 12.5 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 GWT1 YfhO PF09586.10 EWC47358.1 - 1.2 7.2 2.3 1.4 7.0 0.3 1.9 2 0 0 2 2 2 0 Bacterial membrane protein YfhO DUF639 PF04842.12 EWC47358.1 - 4.1 6.8 7.0 3.1 7.2 2.3 2.6 3 0 0 3 3 3 0 Plant protein of unknown function (DUF639) DUF3449 PF11931.8 EWC47359.1 - 7.8e-77 257.2 0.5 7.8e-77 257.2 0.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EWC47359.1 - 7.9e-24 84.0 2.7 2.2e-23 82.6 2.7 1.7 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EWC47359.1 - 1.1e-14 54.0 0.7 3.7e-14 52.3 0.7 2.0 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 EWC47359.1 - 4.1e-10 39.7 5.1 1.8e-08 34.5 0.9 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EWC47359.1 - 1.5e-07 31.5 1.4 3.5e-07 30.3 0.6 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EWC47359.1 - 0.00042 20.6 0.5 0.039 14.3 0.1 2.6 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) PRP9_N PF16958.5 EWC47359.1 - 0.012 15.6 10.3 0.29 11.1 0.1 3.0 2 1 1 3 3 3 0 Pre-mRNA-splicing factor PRP9 N-terminus Herpes_UL32 PF06070.11 EWC47359.1 - 0.029 12.1 1.5 0.052 11.3 1.5 1.4 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 zf-C2H2_4 PF13894.6 EWC47359.1 - 0.089 13.7 2.4 1.7 9.7 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger C1_2 PF03107.16 EWC47359.1 - 0.34 11.3 1.4 14 6.1 0.1 2.5 2 0 0 2 2 2 0 C1 domain zf-C2H2 PF00096.26 EWC47359.1 - 4.5 7.9 5.5 2.6 8.7 0.6 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type DEAD PF00270.29 EWC47360.1 - 6.5e-43 146.5 0.2 1.2e-42 145.7 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC47360.1 - 9.4e-33 112.9 0.1 4.4e-32 110.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47360.1 - 6.4e-05 23.0 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EWC47360.1 - 0.00022 21.0 0.0 0.00034 20.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EWC47360.1 - 0.00029 21.2 0.1 0.0063 16.9 0.1 2.3 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 EWC47360.1 - 0.021 14.7 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Helicase Flavi_DEAD PF07652.14 EWC47360.1 - 0.027 14.4 0.9 0.077 13.0 0.1 2.2 2 2 0 2 2 2 0 Flavivirus DEAD domain TniB PF05621.11 EWC47360.1 - 0.08 12.3 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 EWC47360.1 - 0.22 11.8 0.9 1.1 9.5 0.9 2.0 1 1 0 1 1 1 0 AAA domain RmlD_sub_bind PF04321.17 EWC47361.1 - 1.1e-54 185.5 0.0 1.3e-54 185.2 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EWC47361.1 - 4.5e-23 82.0 0.0 5.4e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EWC47361.1 - 2.2e-09 37.2 0.0 1.2e-08 34.7 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EWC47361.1 - 1.8e-06 27.2 0.0 1.1e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EWC47361.1 - 4.9e-06 25.9 0.0 0.0038 16.4 0.0 2.9 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EWC47361.1 - 1.1e-05 24.8 0.0 0.0034 16.6 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EWC47361.1 - 0.0044 16.9 0.0 0.013 15.4 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EWC47361.1 - 0.006 16.1 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 EWC47361.1 - 0.022 14.3 1.1 0.035 13.7 0.5 1.6 2 0 0 2 2 2 0 NmrA-like family DapB_N PF01113.20 EWC47361.1 - 0.06 13.5 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Tau95 PF09734.9 EWC47362.1 - 9.3e-34 117.2 1.1 1.5e-33 116.6 1.1 1.3 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EWC47362.1 - 1.5e-27 96.3 0.0 2.9e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 Tau95 Triple barrel domain GFO_IDH_MocA PF01408.22 EWC47363.1 - 1e-17 65.0 0.0 1.6e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Syntaxin-6_N PF09177.11 EWC47364.1 - 5.9e-23 81.3 0.7 8.4e-22 77.6 0.0 2.2 2 0 0 2 2 2 1 Syntaxin 6, N-terminal TBCA PF02970.16 EWC47364.1 - 0.0021 18.4 3.2 0.33 11.3 1.3 2.4 2 0 0 2 2 2 2 Tubulin binding cofactor A TPR_2 PF07719.17 EWC47365.1 - 4.6e-26 88.8 8.9 0.00013 21.8 0.3 11.2 11 1 0 11 11 11 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC47365.1 - 7.2e-26 90.2 16.1 4.5e-23 81.3 0.2 5.3 5 1 1 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EWC47365.1 - 9.2e-26 88.6 2.9 4.6e-06 26.2 0.9 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EWC47365.1 - 6e-18 64.9 6.1 1.3e-05 25.4 0.0 8.1 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 EWC47365.1 - 4.7e-17 62.3 2.8 0.067 13.7 0.0 6.9 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47365.1 - 9.6e-17 59.7 10.6 1.6e-05 24.7 0.7 7.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EWC47365.1 - 4.7e-13 48.6 8.2 0.0026 17.4 0.0 6.8 7 0 0 7 7 7 4 TPR repeat TPR_14 PF13428.6 EWC47365.1 - 9.1e-13 47.9 3.4 1.4 9.9 0.0 8.3 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47365.1 - 9.3e-10 39.0 9.1 0.037 14.7 0.0 7.5 5 3 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EWC47365.1 - 1.1e-09 37.7 12.5 0.0087 16.0 0.1 7.8 9 1 0 9 9 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EWC47365.1 - 3.3e-07 30.2 0.7 7 7.3 0.0 6.7 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EWC47365.1 - 1.4e-06 28.5 12.1 0.13 12.9 0.4 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 EWC47365.1 - 6.3e-06 25.9 8.7 0.0061 16.4 0.1 5.4 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_21 PF09976.9 EWC47365.1 - 4e-05 23.4 5.1 0.004 16.9 1.6 4.2 4 1 0 4 4 3 1 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 EWC47365.1 - 0.00021 20.6 2.7 2 7.6 0.2 4.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 EWC47365.1 - 0.0006 20.2 0.0 0.56 11.0 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EWC47365.1 - 0.0016 17.8 2.5 0.3 10.4 0.9 3.8 3 1 0 3 3 3 1 MalT-like TPR region RPN7 PF10602.9 EWC47365.1 - 0.014 15.1 0.0 6.1 6.5 0.0 3.7 3 1 0 3 3 3 0 26S proteasome subunit RPN7 SRP_TPR_like PF17004.5 EWC47365.1 - 0.026 14.5 3.7 5.2 7.1 0.2 3.5 2 1 1 3 3 3 0 Putative TPR-like repeat TPR_20 PF14561.6 EWC47365.1 - 0.088 13.2 0.2 71 3.8 0.0 4.5 5 1 1 6 6 4 0 Tetratricopeptide repeat ANAPC5 PF12862.7 EWC47365.1 - 0.094 12.8 0.3 28 4.9 0.0 3.9 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 5 MIT PF04212.18 EWC47365.1 - 2.2 8.4 5.8 88 3.3 0.1 4.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TT_ORF2 PF02957.15 EWC47365.1 - 2.6 9.0 4.1 1.7 9.6 0.4 2.3 2 0 0 2 2 2 0 TT viral ORF2 Fis1_TPR_C PF14853.6 EWC47365.1 - 2.9 8.0 11.6 18 5.5 0.1 5.1 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat CoaE PF01121.20 EWC47366.1 - 8.9e-44 149.3 0.0 1.6e-43 148.4 0.0 1.4 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EWC47366.1 - 0.0049 17.4 0.1 0.26 11.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain SKI PF01202.22 EWC47366.1 - 0.07 13.3 0.0 13 5.9 0.0 2.4 3 0 0 3 3 3 0 Shikimate kinase B56 PF01603.20 EWC47367.1 - 1.2e-192 640.4 1.5 1.5e-192 640.1 1.5 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EWC47367.1 - 8.1e-05 22.6 1.0 0.23 11.4 0.0 2.5 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal ATP-synt_ab PF00006.25 EWC47368.1 - 1.9e-107 357.7 0.0 2.6e-107 357.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EWC47368.1 - 6e-45 152.0 0.0 1.1e-44 151.2 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EWC47368.1 - 9.6e-08 32.4 0.7 2.8e-07 30.9 0.7 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Biotin_lipoyl PF00364.22 EWC47368.1 - 0.049 13.5 0.0 2.8 7.8 0.0 2.7 2 0 0 2 2 2 0 Biotin-requiring enzyme DUF763 PF05559.11 EWC47368.1 - 0.13 11.4 0.3 4.3 6.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF763) WD40 PF00400.32 EWC47369.1 - 5.6e-35 118.8 17.4 7.8e-08 32.9 0.3 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47369.1 - 1.4e-14 54.1 3.2 0.0025 18.0 0.0 5.2 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EWC47369.1 - 3e-08 33.8 0.5 3.9e-06 26.9 0.1 2.9 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EWC47369.1 - 3.3e-07 29.6 0.4 0.0019 17.3 0.1 3.1 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EWC47369.1 - 1.7e-05 23.4 0.0 0.11 10.8 0.0 2.3 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz CLTH PF10607.9 EWC47369.1 - 5e-05 23.2 2.3 0.00014 21.8 2.5 1.6 1 1 1 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain PD40 PF07676.12 EWC47369.1 - 0.00022 21.0 0.1 8.8 6.4 0.0 4.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 EWC47369.1 - 0.00033 20.1 0.0 0.002 17.5 0.0 1.9 1 1 1 2 2 2 2 WD40-like domain Coatomer_WDAD PF04053.14 EWC47369.1 - 0.063 12.3 0.3 0.46 9.5 0.0 2.2 1 1 1 2 2 2 0 Coatomer WD associated region KH_2 PF07650.17 EWC47369.1 - 0.18 11.7 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 KH domain PH PF00169.29 EWC47371.1 - 0.034 14.7 0.1 0.19 12.3 0.1 2.2 2 0 0 2 2 2 0 PH domain MCM2_N PF12619.8 EWC47371.1 - 2.3 8.5 9.0 0.81 10.0 1.8 2.7 2 1 1 3 3 3 0 Mini-chromosome maintenance protein 2 Pectate_lyase_3 PF12708.7 EWC47372.1 - 9.6e-86 287.1 11.4 6.7e-77 258.2 6.7 4.9 6 0 0 6 6 6 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EWC47372.1 - 5.1e-06 26.1 2.5 0.024 14.3 0.1 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase DUF1489 PF07370.11 EWC47372.1 - 0.019 14.7 0.7 78 3.0 0.0 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1489) PPR_long PF17177.4 EWC47372.1 - 0.084 12.2 0.0 17 4.7 0.0 3.6 4 0 0 4 4 4 0 Pentacotripeptide-repeat region of PRORP A_amylase_inhib PF01356.19 EWC47372.1 - 0.6 10.1 19.7 1.7 8.7 0.5 5.1 5 0 0 5 5 5 0 Alpha amylase inhibitor Period_C PF12114.8 EWC47372.1 - 7.5 6.1 15.8 3.3 7.2 0.0 2.6 2 0 0 2 2 2 0 Period protein 2/3C-terminal region Dynamin_M PF01031.20 EWC47374.1 - 1.7e-100 336.0 0.0 1.7e-100 336.0 0.0 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EWC47374.1 - 3.2e-55 186.8 0.1 7.5e-55 185.5 0.1 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EWC47374.1 - 4.7e-30 103.6 5.0 4.7e-30 103.6 5.0 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EWC47374.1 - 2.8e-05 24.2 0.4 0.00018 21.6 0.4 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EWC47374.1 - 0.023 14.4 4.2 2.2 7.9 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain AIG1 PF04548.16 EWC47374.1 - 0.046 13.0 0.3 4.7 6.5 0.0 2.6 2 0 0 2 2 2 0 AIG1 family MCM PF00493.23 EWC47375.1 - 1.8e-103 344.4 0.1 3.7e-103 343.4 0.0 1.5 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EWC47375.1 - 3.1e-36 124.0 0.1 7.6e-36 122.7 0.1 1.7 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EWC47375.1 - 1.3e-28 99.2 2.7 3.2e-28 98.0 2.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EWC47375.1 - 4.9e-16 59.2 0.0 1.3e-15 57.8 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EWC47375.1 - 8.2e-06 25.3 0.0 0.002 17.5 0.0 2.5 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EWC47375.1 - 2.1e-05 24.6 0.0 5e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EWC47375.1 - 0.00066 19.5 0.0 0.0031 17.4 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EWC47375.1 - 0.06 13.8 0.5 1.9 8.9 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 EWC47375.1 - 0.2 12.3 3.5 0.75 10.5 0.3 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal Vps54 PF07928.12 EWC47376.1 - 3.1e-51 173.3 0.0 8.3e-51 171.9 0.0 1.8 1 0 0 1 1 1 1 Vps54-like protein DUF2451 PF10474.9 EWC47376.1 - 7.9e-07 29.1 0.0 2.3e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 EWC47376.1 - 0.00017 20.9 0.6 0.00057 19.3 0.6 1.8 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex CENP-F_leu_zip PF10473.9 EWC47376.1 - 0.2 11.7 1.9 0.48 10.5 1.9 1.6 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NUDIX_2 PF13869.6 EWC47377.1 - 5.3e-80 267.5 0.0 6.3e-80 267.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase Methyltransf_32 PF13679.6 EWC47378.1 - 1.5e-26 93.3 0.0 2.6e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Glyco_transf_90 PF05686.12 EWC47379.1 - 6.3e-17 61.6 0.0 3.8e-15 55.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 90 CN_hydrolase PF00795.22 EWC47380.1 - 1.3e-42 146.0 0.0 1.7e-42 145.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EWC47380.1 - 1.1e-24 86.9 0.0 2.6e-24 85.7 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 EWC47380.1 - 0.028 14.1 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase TrkH PF02386.16 EWC47381.1 - 2.7e-145 484.6 10.4 7.9e-145 483.1 3.3 2.1 2 0 0 2 2 2 2 Cation transport protein dbPDZ_assoc PF16610.5 EWC47381.1 - 1.5 9.1 5.1 0.6 10.4 0.9 2.3 2 0 0 2 2 2 0 Unstructured region between two PDZ domains on Dlg5 DUF4407 PF14362.6 EWC47382.1 - 0.076 12.4 2.4 0.17 11.2 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) SRR1 PF07985.12 EWC47383.1 - 2.5e-10 40.3 0.0 3.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 SRR1 DNA_ligase_A_M PF01068.21 EWC47384.1 - 9.5e-20 71.1 0.0 1.5e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EWC47384.1 - 7.3e-14 52.5 0.0 1.8e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 DNA ligase N terminus COX5A PF02284.16 EWC47385.1 - 1.9e-41 140.3 0.4 2.1e-41 140.1 0.4 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va ELO PF01151.18 EWC47386.1 - 5.4e-60 203.0 24.1 7.7e-60 202.5 24.1 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Glyco_transf_4 PF13439.6 EWC47386.1 - 1.2 9.1 3.3 6.4 6.7 0.0 2.6 2 1 1 3 3 3 0 Glycosyltransferase Family 4 GST_N_3 PF13417.6 EWC47387.1 - 1.8e-12 47.5 0.0 2.9e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EWC47387.1 - 3.4e-11 43.3 0.0 5.2e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EWC47387.1 - 2.1e-08 34.4 0.0 4.6e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EWC47387.1 - 0.0026 18.0 0.0 0.005 17.0 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin F-box-like PF12937.7 EWC47388.1 - 1.2e-09 37.9 2.0 6e-09 35.6 0.1 2.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EWC47388.1 - 0.28 11.1 5.3 50 3.9 0.2 3.5 3 0 0 3 3 3 0 F-box domain zf-RanBP PF00641.18 EWC47389.1 - 6.1e-18 63.8 11.0 6.7e-10 38.1 1.5 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EWC47389.1 - 8.6e-08 31.9 0.0 1.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 EWC47389.1 - 1.7e-07 31.9 0.0 2.6e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DZR PF12773.7 EWC47389.1 - 0.57 10.2 5.1 1.8 8.7 0.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon DUF572 PF04502.13 EWC47390.1 - 2.9e-74 250.7 10.2 3.4e-74 250.4 10.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DNA_RNApol_7kD PF03604.13 EWC47390.1 - 0.0098 15.6 2.5 1 9.1 0.6 2.5 2 0 0 2 2 2 2 DNA directed RNA polymerase, 7 kDa subunit zf-ACC PF17848.1 EWC47390.1 - 0.4 10.8 2.7 2.8 8.1 0.5 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain NAD_binding_10 PF13460.6 EWC47392.1 - 2e-08 34.3 0.0 3.8e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EWC47392.1 - 4.4e-08 32.9 0.0 0.00021 20.8 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EWC47392.1 - 1.1e-05 25.1 0.0 0.0017 18.0 0.0 2.3 2 0 0 2 2 2 2 NmrA-like family Sacchrp_dh_NADP PF03435.18 EWC47392.1 - 9.4e-05 22.7 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Fibrillarin PF01269.17 EWC47392.1 - 0.0017 17.5 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 Fibrillarin TrkA_N PF02254.18 EWC47392.1 - 0.0056 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain DapB_N PF01113.20 EWC47392.1 - 0.026 14.6 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 EWC47392.1 - 0.026 13.6 0.0 0.21 10.7 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EWC47392.1 - 0.035 13.5 0.0 0.54 9.6 0.0 2.3 2 1 1 3 3 3 0 GDP-mannose 4,6 dehydratase Hydrolase_4 PF12146.8 EWC47393.1 - 0.0016 17.7 0.0 0.025 13.9 0.0 2.4 2 1 0 2 2 2 1 Serine aminopeptidase, S33 PhoPQ_related PF10142.9 EWC47393.1 - 0.0028 16.4 0.0 0.0043 15.8 0.0 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Abhydrolase_4 PF08386.10 EWC47393.1 - 0.023 14.8 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein adh_short PF00106.25 EWC47397.1 - 2.2e-09 37.1 0.0 5.5e-09 35.8 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC47397.1 - 4.1e-05 23.3 0.0 6.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC47397.1 - 0.00024 21.1 0.0 0.00041 20.3 0.0 1.3 1 0 0 1 1 1 1 KR domain MAPEG PF01124.18 EWC47398.1 - 8.7e-22 77.4 0.1 1e-21 77.2 0.1 1.1 1 0 0 1 1 1 1 MAPEG family UPF0047 PF01894.17 EWC47400.1 - 6.4e-35 119.8 0.0 1.1e-34 119.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Ribosomal_S21 PF01165.20 EWC47400.1 - 0.091 12.5 0.2 0.29 10.9 0.2 1.9 1 0 0 1 1 1 0 Ribosomal protein S21 UPF0029 PF01205.19 EWC47402.1 - 1.4e-21 76.8 0.0 2e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 LPMO_10 PF03067.15 EWC47403.1 - 0.0011 19.6 0.3 0.0037 17.9 0.0 2.0 2 1 1 3 3 3 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading GRA6 PF05084.13 EWC47403.1 - 0.059 13.3 2.8 0.12 12.3 2.8 1.5 1 0 0 1 1 1 0 Granule antigen protein (GRA6) DUF3433 PF11915.8 EWC47404.1 - 1.5e-33 115.1 14.2 4.5e-18 65.5 1.6 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) Fungal_trans PF04082.18 EWC47405.1 - 2.8e-19 69.2 0.1 4.5e-19 68.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC47405.1 - 0.0055 16.8 9.5 0.011 15.8 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FA_hydroxylase PF04116.13 EWC47406.1 - 4.2e-21 75.7 12.4 4.2e-21 75.7 12.4 1.7 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily HPS6 PF15702.5 EWC47406.1 - 0.033 12.2 0.0 0.038 12.0 0.0 1.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 6 protein Ribosomal_L4 PF00573.22 EWC47407.1 - 1.3e-36 126.1 0.2 1.3e-36 126.1 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EWC47407.1 - 5.3e-28 96.9 1.2 7e-28 96.5 0.1 1.8 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain SR-25 PF10500.9 EWC47408.1 - 0.00012 21.8 11.4 0.00012 21.8 11.4 4.2 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein F-box-like PF12937.7 EWC47409.1 - 6.4e-08 32.4 0.0 6.4e-08 32.4 0.0 2.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EWC47409.1 - 0.01 15.7 0.0 0.01 15.7 0.0 2.4 3 0 0 3 3 3 0 F-box domain zf-CHCC PF10276.9 EWC47410.1 - 5e-17 61.7 2.0 7.2e-17 61.2 2.0 1.3 1 0 0 1 1 1 1 Zinc-finger domain NAP PF00956.18 EWC47411.1 - 5.4e-22 78.3 0.1 2.7e-21 75.9 0.1 2.0 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Peptidase_M16_M PF16187.5 EWC47413.1 - 2e-91 306.2 1.6 6.4e-91 304.5 0.2 2.1 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EWC47413.1 - 1.8e-37 128.6 3.7 3e-37 127.9 0.1 2.5 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EWC47413.1 - 4.9e-22 78.8 0.1 4e-17 62.8 0.0 3.6 4 0 0 4 4 4 2 Peptidase M16 inactive domain Elongin_A PF06881.11 EWC47413.1 - 0.33 11.5 2.3 0.68 10.5 2.3 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Pectate_lyase_3 PF12708.7 EWC47414.1 - 1.5e-86 289.7 11.8 2.1e-77 259.8 6.9 2.9 2 1 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EWC47414.1 - 7.6e-07 28.7 1.3 0.0069 16.1 0.4 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase zf-C2H2 PF00096.26 EWC47415.1 - 1.1e-09 38.2 31.4 0.0096 16.3 1.6 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC47415.1 - 0.0023 18.6 1.8 0.0023 18.6 1.8 6.3 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EWC47415.1 - 0.022 15.4 6.6 1.1 9.9 0.3 3.8 4 0 0 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 EWC47415.1 - 0.031 14.6 1.9 0.13 12.5 1.9 2.2 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EWC47415.1 - 0.032 14.6 4.0 5.7 7.3 0.0 3.6 2 2 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EWC47415.1 - 0.49 10.9 6.7 0.25 11.8 0.9 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EWC47415.1 - 0.72 10.0 5.5 0.16 12.1 1.5 1.9 2 1 0 2 2 2 0 Aberrant zinc-finger Nucleotid_trans PF03407.16 EWC47416.1 - 0.004 17.2 0.1 0.0095 15.9 0.0 1.6 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase IPP-2 PF04979.14 EWC47419.1 - 3.8e-18 66.5 20.7 6e-18 65.9 15.4 2.7 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) F-box-like PF12937.7 EWC47420.1 - 0.024 14.5 0.1 0.08 12.8 0.2 1.8 2 0 0 2 2 2 0 F-box-like EHN PF06441.12 EWC47421.1 - 1.8e-35 121.6 0.5 6.3e-34 116.6 0.0 2.2 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EWC47421.1 - 4.8e-11 42.8 0.1 8.2e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Malic_M PF03949.15 EWC47422.1 - 1.7e-88 296.2 0.0 2.6e-88 295.6 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EWC47422.1 - 1.7e-67 226.8 0.0 2.7e-67 226.1 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain HD PF01966.22 EWC47424.1 - 1.5e-05 25.2 0.1 3.7e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 HD domain DUF1534 PF07551.11 EWC47424.1 - 0.085 12.6 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1534) RMI1_C PF16099.5 EWC47424.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold MFS_1 PF07690.16 EWC47425.1 - 4.1e-32 111.5 29.0 5.9e-32 111.0 29.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily NCE101 PF11654.8 EWC47425.1 - 1.7 8.4 5.6 8.3 6.2 2.1 3.3 2 1 0 2 2 2 0 Non-classical export protein 1 BRCT PF00533.26 EWC47426.1 - 3.1e-09 37.1 0.0 1.6e-08 34.8 0.0 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Rad9_Rad53_bind PF08605.10 EWC47426.1 - 2.4e-06 27.8 0.0 4.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT_3 PF18428.1 EWC47426.1 - 0.00011 22.2 0.0 0.83 9.8 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EWC47426.1 - 0.00016 22.0 0.0 0.00088 19.6 0.0 2.2 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EWC47426.1 - 0.0011 18.8 0.0 0.0053 16.6 0.0 2.1 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain Tudor_3 PF18115.1 EWC47426.1 - 0.0013 18.5 0.0 0.0028 17.5 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Campylo_MOMP PF05538.11 EWC47426.1 - 0.2 10.6 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Campylobacter major outer membrane protein F-box-like PF12937.7 EWC47429.1 - 0.0068 16.3 0.0 0.02 14.7 0.0 1.8 1 0 0 1 1 1 1 F-box-like Gtr1_RagA PF04670.12 EWC47430.1 - 7.3e-96 320.0 0.0 9.4e-96 319.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Sdh_cyt PF01127.22 EWC47430.1 - 9.8e-23 80.5 2.8 1.9e-22 79.5 1.9 1.9 2 0 0 2 2 2 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Roc PF08477.13 EWC47430.1 - 6.2e-07 29.7 0.0 1.2e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EWC47430.1 - 1.1e-06 28.7 0.0 2.6e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 EWC47430.1 - 8.5e-06 25.5 0.0 2.4e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 Ras family Arf PF00025.21 EWC47430.1 - 1.7e-05 24.3 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF815 PF05673.13 EWC47430.1 - 0.023 13.9 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 EWC47430.1 - 0.027 14.2 0.1 0.063 13.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EWC47430.1 - 0.066 12.4 6.4 1.4 8.0 1.0 2.5 2 1 1 3 3 3 0 G-protein alpha subunit ABC_tran PF00005.27 EWC47430.1 - 0.074 13.6 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EWC47430.1 - 0.12 12.3 0.1 0.78 9.6 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase Amidohydro_3 PF07969.11 EWC47431.1 - 9.6e-70 236.3 0.4 1.3e-69 235.9 0.4 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EWC47431.1 - 4.3e-11 42.7 0.0 1.7e-07 30.9 0.0 3.1 3 0 0 3 3 3 3 Amidohydrolase family Kelch_5 PF13854.6 EWC47432.1 - 1e-15 57.3 7.9 0.00069 19.5 0.1 6.4 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EWC47432.1 - 1.1e-12 47.8 17.5 6.3e-05 22.9 0.1 6.2 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EWC47432.1 - 2.5e-09 36.6 7.1 0.00059 19.4 0.0 5.3 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 EWC47432.1 - 4.6e-08 33.1 14.5 0.038 14.3 0.0 5.9 5 1 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EWC47432.1 - 5.9e-08 32.8 17.8 8.8e-05 22.7 0.6 5.5 7 0 0 7 7 7 2 Galactose oxidase, central domain SKG6 PF08693.10 EWC47432.1 - 1.8e-07 30.4 0.4 3.4e-07 29.6 0.4 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_2 PF07646.15 EWC47432.1 - 0.00041 20.2 6.5 1.3 9.1 0.0 5.7 6 1 0 6 6 6 1 Kelch motif DUF4448 PF14610.6 EWC47432.1 - 0.048 13.4 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3040 PF11239.8 EWC47432.1 - 0.16 12.3 0.1 0.49 10.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) TAF6_C PF07571.13 EWC47433.1 - 2.6e-25 88.5 0.0 6.5e-25 87.3 0.0 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EWC47433.1 - 2.5e-13 50.0 0.3 5.6e-13 48.9 0.3 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EWC47433.1 - 0.021 15.2 0.2 0.021 15.2 0.2 4.1 4 1 2 6 6 6 0 Core histone H2A/H2B/H3/H4 Dioxygenase_C PF00775.21 EWC47434.1 - 4.8e-37 127.1 0.0 6.5e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EWC47434.1 - 3.7e-31 106.8 0.0 6.4e-31 106.0 0.0 1.4 1 0 0 1 1 1 1 Catechol dioxygenase N terminus Big_1 PF02369.16 EWC47434.1 - 0.054 13.5 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) ACOX PF01756.19 EWC47434.1 - 0.09 12.3 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Acyl-CoA oxidase DUF824 PF05688.11 EWC47434.1 - 0.15 11.9 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) Thiolase_N PF00108.23 EWC47435.1 - 3.7e-64 216.6 0.9 2.5e-63 213.9 0.4 2.2 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EWC47435.1 - 1.5e-39 134.5 0.3 3.4e-39 133.3 0.3 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain AAA PF00004.29 EWC47437.1 - 6.3e-19 68.7 0.0 1.6e-18 67.4 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC47437.1 - 0.031 14.6 0.0 0.68 10.3 0.0 2.5 1 1 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 EWC47437.1 - 0.062 13.7 0.0 0.2 12.0 0.0 1.9 1 1 0 1 1 1 0 RNA helicase GREB1 PF15782.5 EWC47437.1 - 0.086 10.0 3.6 0.11 9.6 3.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_23 PF13476.6 EWC47437.1 - 0.13 12.7 0.3 0.48 10.9 0.3 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EWC47437.1 - 0.14 12.4 0.1 2.3 8.5 0.1 2.9 3 1 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EWC47437.1 - 0.16 12.3 0.0 0.65 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain MAP65_ASE1 PF03999.12 EWC47437.1 - 0.2 10.3 3.5 0.31 9.7 3.5 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) BASP1 PF05466.12 EWC47437.1 - 8.6 6.3 8.6 13 5.7 8.6 1.2 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) RgpF PF05045.12 EWC47438.1 - 0.00077 18.3 0.0 0.0029 16.4 0.0 1.8 2 0 0 2 2 2 1 Rhamnan synthesis protein F Adap_comp_sub PF00928.21 EWC47439.1 - 2.9e-89 299.0 0.1 4.4e-89 298.4 0.1 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EWC47439.1 - 2.7e-08 33.9 0.3 4.8e-08 33.0 0.3 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EWC47439.1 - 0.024 14.1 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Glyco_trans_1_4 PF13692.6 EWC47442.1 - 5.8e-06 26.8 0.0 2.5e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EWC47442.1 - 3.7e-05 24.2 0.0 6.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 EWC47442.1 - 0.00019 21.0 0.0 0.00037 20.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EWC47442.1 - 0.0011 19.0 0.0 0.0024 17.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase Family 4 ERCC3_RAD25_C PF16203.5 EWC47443.1 - 3.2e-121 403.2 0.2 5.7e-121 402.4 0.2 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EWC47443.1 - 2.5e-35 121.4 0.0 5.9e-35 120.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47443.1 - 5.2e-16 59.1 0.0 1e-15 58.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EWC47443.1 - 1.9e-11 44.3 0.1 4.5e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EWC47443.1 - 2.6e-07 29.7 0.0 3.2e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-4CXXC_R1 PF10497.9 EWC47444.1 - 2.1 8.6 6.3 0.28 11.4 0.9 2.3 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 FSA_C PF10479.9 EWC47445.1 - 2.9 5.9 7.6 3.6 5.6 7.6 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Methyltransf_25 PF13649.6 EWC47446.1 - 1.8e-05 25.4 0.0 4.4e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC47446.1 - 0.0077 16.9 0.0 0.015 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC47446.1 - 0.021 14.6 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EWC47446.1 - 0.06 14.1 0.1 0.24 12.1 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain NIF3 PF01784.18 EWC47448.1 - 2.2e-64 217.4 0.0 2.8e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) EppA_BapA PF07268.11 EWC47449.1 - 0.02 14.8 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 Exported protein precursor (EppA/BapA) RhgB_N PF09284.10 EWC47450.1 - 3.8e-101 337.8 2.6 7e-101 337.0 2.6 1.4 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 EWC47450.1 - 7.8e-36 123.4 0.0 2.7e-35 121.7 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EWC47450.1 - 1.9e-20 72.4 2.4 8.8e-20 70.3 2.4 2.3 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CBM_1 PF00734.18 EWC47450.1 - 3.5e-12 46.0 16.4 3.5e-12 46.0 16.4 1.9 2 0 0 2 2 2 1 Fungal cellulose binding domain CENP-Q PF13094.6 EWC47451.1 - 0.26 11.5 0.0 0.26 11.5 0.0 3.1 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Methyltransf_25 PF13649.6 EWC47452.1 - 2.4e-13 50.6 0.0 4.1e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC47452.1 - 6.1e-13 48.6 0.0 5e-12 45.7 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EWC47452.1 - 1.7e-12 47.8 0.0 2.7e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC47452.1 - 1.9e-05 24.5 0.0 3.4e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC47452.1 - 0.00047 20.0 0.0 0.001 18.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC47452.1 - 0.027 15.2 0.0 0.041 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain AviRa PF11599.8 EWC47452.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Phospholip_A2_3 PF09056.11 EWC47453.1 - 8.8e-28 97.2 0.1 1.3e-27 96.7 0.1 1.2 1 0 0 1 1 1 1 Prokaryotic phospholipase A2 Questin_oxidase PF14027.6 EWC47454.1 - 2.9e-89 300.0 2.5 3.6e-89 299.7 2.5 1.1 1 0 0 1 1 1 1 Questin oxidase-like FAO_M PF16350.5 EWC47455.1 - 0.055 13.8 0.1 0.077 13.3 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase central domain HAT_KAT11 PF08214.11 EWC47456.1 - 9.9e-79 265.2 0.0 1.3e-78 264.8 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein FAM91_C PF14648.6 EWC47456.1 - 0.14 10.9 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 FAM91 C-terminus Ribonucleas_3_3 PF14622.6 EWC47457.1 - 1.3e-20 73.8 0.0 8e-20 71.3 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease-III-like BTV_NS2 PF04514.12 EWC47457.1 - 0.12 11.2 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 LDB19 PF13002.7 EWC47459.1 - 9.5e-11 41.8 0.1 2e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EWC47459.1 - 0.0016 18.5 0.2 0.0035 17.4 0.1 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain HET PF06985.11 EWC47461.1 - 3.5e-31 108.5 0.6 7.5e-31 107.5 0.6 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF5056 PF16479.5 EWC47461.1 - 0.19 12.0 0.1 1.6 9.0 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5056) SQHop_cyclase_C PF13243.6 EWC47462.1 - 8.5e-51 172.9 2.8 1.1e-48 166.0 1.6 2.4 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EWC47462.1 - 1.5e-45 155.5 4.6 5.8e-41 140.5 0.1 4.4 3 2 3 6 6 6 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EWC47462.1 - 1.5e-27 95.0 14.4 2.3e-09 36.8 0.2 5.5 7 0 0 7 7 7 4 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EWC47462.1 - 0.00083 18.5 0.2 0.64 9.0 0.0 3.4 1 1 1 3 3 3 1 A-macroglobulin TED domain Pec_lyase PF09492.10 EWC47462.1 - 0.03 13.6 1.7 19 4.5 0.0 4.0 4 1 1 5 5 5 0 Pectic acid lyase CBM_1 PF00734.18 EWC47464.1 - 8.3e-07 28.9 40.6 0.00026 20.9 9.4 7.0 7 1 0 7 7 7 3 Fungal cellulose binding domain CAF1A PF12253.8 EWC47466.1 - 4e-20 71.8 1.7 4e-20 71.8 1.7 3.6 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A Mitofilin PF09731.9 EWC47466.1 - 1.7 7.4 25.8 0.14 11.0 20.3 1.7 2 0 0 2 2 2 0 Mitochondrial inner membrane protein EXS PF03124.14 EWC47467.1 - 6.4e-91 305.1 39.4 8e-91 304.8 39.4 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EWC47467.1 - 9.8e-70 236.4 0.3 9.8e-70 236.4 0.3 1.9 2 0 0 2 2 2 1 SPX domain Ank_5 PF13857.6 EWC47468.1 - 9.9e-15 54.4 1.8 6.7e-08 32.7 0.4 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EWC47468.1 - 1.7e-14 54.0 0.4 1.4e-06 28.7 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC47468.1 - 1.4e-13 49.7 0.2 7.9e-07 28.9 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EWC47468.1 - 1.6e-13 51.0 0.1 4e-07 30.5 0.0 2.5 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EWC47468.1 - 4.1e-12 46.0 0.9 1.3e-06 28.6 0.3 2.6 2 0 0 2 2 2 2 Ankyrin repeat DUF3759 PF12585.8 EWC47469.1 - 9.1e-31 105.7 14.3 9.1e-31 105.7 14.3 2.0 1 1 0 2 2 2 1 Protein of unknown function (DUF3759) DUF3759 PF12585.8 EWC47470.1 - 1.1e-27 95.9 2.9 1.1e-27 95.9 2.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3759) PBP1_TM PF14812.6 EWC47470.1 - 1 9.7 10.0 2.1 8.7 6.5 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3759 PF12585.8 EWC47471.1 - 4.9e-33 113.0 8.9 4.9e-33 113.0 8.9 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3759) TMEM154 PF15102.6 EWC47472.1 - 0.059 13.3 0.3 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family SR-25 PF10500.9 EWC47472.1 - 0.12 11.9 11.8 0.27 10.8 11.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PRIMA1 PF16101.5 EWC47472.1 - 0.34 10.9 0.0 0.34 10.9 0.0 2.9 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 DUF1688 PF07958.11 EWC47473.1 - 2.7e-174 579.8 0.0 3.1e-174 579.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) PQ-loop PF04193.14 EWC47474.1 - 7.5e-41 137.7 11.9 8.2e-21 73.6 2.4 2.7 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EWC47474.1 - 0.0067 17.3 0.8 0.69 10.7 0.2 2.5 2 0 0 2 2 2 2 ER lumen protein retaining receptor SGS PF05002.15 EWC47477.1 - 2.7e-34 117.1 2.9 7.3e-34 115.7 2.9 1.8 1 0 0 1 1 1 1 SGS domain CS PF04969.16 EWC47477.1 - 4.3e-15 56.5 0.0 7.6e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 CS domain TPR_12 PF13424.6 EWC47477.1 - 0.00069 19.9 5.5 0.029 14.7 2.0 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47477.1 - 0.0014 18.6 3.8 0.13 12.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47477.1 - 0.0034 17.1 0.4 0.17 11.8 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EWC47477.1 - 0.031 13.9 0.2 0.058 13.1 0.2 1.5 1 0 0 1 1 1 0 TPR repeat B12D PF06522.11 EWC47479.1 - 0.35 10.7 1.1 0.39 10.6 0.0 1.6 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit SUR7 PF06687.12 EWC47479.1 - 0.73 9.4 6.7 0.74 9.4 6.7 1.0 1 0 0 1 1 1 0 SUR7/PalI family CENP-B_dimeris PF09026.10 EWC47480.1 - 0.01 16.2 0.9 0.033 14.6 0.9 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Peptidase_S28 PF05577.12 EWC47482.1 - 8.5e-43 146.7 0.4 1.2e-41 142.9 0.4 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 HetR_C PF18460.1 EWC47482.1 - 0.14 12.1 0.4 0.39 10.7 0.1 1.9 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain Ferric_reduct PF01794.19 EWC47483.1 - 1.3e-19 70.5 6.6 2e-19 69.9 6.6 1.3 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EWC47483.1 - 2.2e-17 63.6 0.0 3.2e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EWC47483.1 - 2.7e-15 56.4 0.0 6e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Borrelia_P83 PF05262.11 EWC47484.1 - 1.8 7.0 5.4 2.6 6.4 5.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Metallophos PF00149.28 EWC47486.1 - 4.5e-39 135.1 0.1 7.4e-39 134.4 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 EWC47486.1 - 0.12 12.1 1.0 2.4 7.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Glyco_hydro_72 PF03198.14 EWC47488.1 - 9.7e-97 324.0 0.1 1.2e-96 323.6 0.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase lci PF12197.8 EWC47488.1 - 0.027 14.3 0.1 6.9 6.6 0.1 2.6 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein Bax1-I PF01027.20 EWC47489.1 - 8.7e-33 113.9 13.9 2.7e-32 112.3 10.3 2.1 2 0 0 2 2 2 2 Inhibitor of apoptosis-promoting Bax1 WXG100 PF06013.12 EWC47490.1 - 0.043 14.0 0.4 0.16 12.2 0.1 2.2 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Ntox28 PF15605.6 EWC47490.1 - 0.062 13.5 0.3 0.5 10.6 0.3 2.5 2 0 0 2 2 2 0 Bacterial toxin 28 Sugarporin_N PF11471.8 EWC47490.1 - 0.07 13.1 0.4 0.31 11.0 0.0 2.3 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Prominin PF05478.11 EWC47490.1 - 0.15 10.0 1.8 0.23 9.4 1.8 1.3 1 0 0 1 1 1 0 Prominin Laminin_II PF06009.12 EWC47490.1 - 0.19 11.8 5.7 10 6.2 3.1 2.6 1 1 1 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 EWC47490.1 - 1.1 9.6 10.1 0.3 11.4 1.1 3.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Alpha-2-MRAP_C PF06401.11 EWC47490.1 - 1.3 9.0 10.5 1.9 8.4 3.1 2.7 1 1 1 3 3 3 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF1690 PF07956.11 EWC47490.1 - 1.4 9.3 15.3 2.6 8.5 0.9 3.1 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) APG6_N PF17675.1 EWC47490.1 - 1.6 9.3 9.9 0.069 13.7 2.4 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region DASH_Duo1 PF08651.10 EWC47490.1 - 2.1 8.2 4.3 12 5.8 0.0 3.4 3 1 1 4 4 4 0 DASH complex subunit Duo1 KxDL PF10241.9 EWC47490.1 - 2.6 8.4 7.4 6.8 7.0 0.1 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein Fib_alpha PF08702.10 EWC47490.1 - 3.9 7.6 8.6 8.7 6.5 0.5 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Spectrin PF00435.21 EWC47490.1 - 8 7.0 12.7 4.3 7.9 1.0 3.3 1 1 2 3 3 3 0 Spectrin repeat K-box PF01486.17 EWC47490.1 - 9.1 6.5 9.3 0.32 11.2 0.7 2.8 3 1 0 3 3 3 0 K-box region HhH-GPD PF00730.25 EWC47491.1 - 0.0057 17.1 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein RR_TM4-6 PF06459.12 EWC47491.1 - 1.7 8.4 16.7 3.2 7.5 16.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Glyco_hydro_28 PF00295.17 EWC47492.1 - 5.4e-52 176.9 2.4 6.8e-52 176.5 2.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Sortilin-Vps10 PF15902.5 EWC47493.1 - 6.9e-14 51.5 11.0 0.00052 18.9 0.2 5.8 5 2 0 5 5 5 4 Sortilin, neurotensin receptor 3, CBM_1 PF00734.18 EWC47493.1 - 9.7e-11 41.4 10.4 3.8e-10 39.5 10.4 2.1 1 0 0 1 1 1 1 Fungal cellulose binding domain BNR PF02012.20 EWC47493.1 - 7.3e-10 37.4 30.7 0.21 11.7 0.9 9.5 8 0 0 8 8 8 5 BNR/Asp-box repeat BNR_6 PF15899.5 EWC47493.1 - 3.3e-06 26.6 13.8 0.0061 16.5 0.3 6.9 8 0 0 8 8 8 2 BNR-Asp box repeat BNR_2 PF13088.6 EWC47493.1 - 0.0003 20.2 8.1 0.068 12.5 0.9 5.2 4 1 1 5 5 5 1 BNR repeat-like domain Abhydrolase_2 PF02230.16 EWC47494.1 - 1.1e-15 58.0 0.0 1.5e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase CLIP_1 PF18322.1 EWC47494.1 - 0.15 12.2 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Serine protease Clip domain PPAF-2 UQ_con PF00179.26 EWC47495.1 - 8.8e-47 158.3 0.0 9.9e-47 158.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EWC47495.1 - 0.055 13.2 0.0 0.19 11.4 0.0 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family B KxDL PF10241.9 EWC47496.1 - 0.044 14.1 3.7 0.058 13.7 0.5 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein ApoC-I PF04691.12 EWC47496.1 - 0.15 12.0 0.5 6.5 6.8 0.1 2.8 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) Peptidase_M18 PF02127.15 EWC47497.1 - 1.2e-131 439.5 0.0 1.5e-131 439.2 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) adh_short_C2 PF13561.6 EWC47498.1 - 3.3e-54 183.9 0.8 4.3e-54 183.6 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EWC47498.1 - 3.1e-35 121.4 0.7 3.8e-35 121.1 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EWC47498.1 - 2.4e-05 24.3 0.7 5.3e-05 23.2 0.3 1.7 2 0 0 2 2 2 1 KR domain 3HCDH_N PF02737.18 EWC47498.1 - 0.012 15.5 0.7 0.02 14.8 0.7 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 EWC47498.1 - 0.031 13.8 0.1 1.5 8.3 0.1 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF3136 PF11334.8 EWC47498.1 - 0.13 12.0 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) RdRP PF05183.12 EWC47499.1 - 5.9e-116 388.5 0.0 1.1e-115 387.6 0.0 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase Yip1 PF04893.17 EWC47500.1 - 1.2 8.8 19.0 1.5 8.5 0.9 3.5 1 1 0 2 2 2 0 Yip1 domain Pectinesterase PF01095.19 EWC47502.1 - 1e-49 168.9 6.3 1e-49 168.9 6.3 1.6 2 0 0 2 2 2 1 Pectinesterase CBM_1 PF00734.18 EWC47502.1 - 6.2e-10 38.9 15.8 2.3e-09 37.1 15.8 2.1 1 0 0 1 1 1 1 Fungal cellulose binding domain DUF959 PF06121.14 EWC47502.1 - 0.03 14.6 1.9 0.061 13.6 1.9 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF959) Voldacs PF03517.13 EWC47503.1 - 7.9e-20 71.4 5.3 1.6e-19 70.4 0.0 3.2 3 1 0 3 3 3 1 Regulator of volume decrease after cellular swelling tRNA-synt_1e PF01406.19 EWC47504.1 - 1.2e-107 359.8 0.0 4.3e-107 358.0 0.0 1.9 2 1 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EWC47504.1 - 0.00014 20.7 0.1 0.24 10.1 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1c PF00749.21 EWC47504.1 - 0.04 12.8 1.4 6.1 5.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF1682 PF07946.14 EWC47504.1 - 0.42 9.8 4.6 0.84 8.8 4.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) GCD14 PF08704.10 EWC47505.1 - 1.1e-66 225.1 0.9 1.3e-35 123.3 0.1 3.2 2 1 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit TFIIF_alpha PF05793.12 EWC47505.1 - 0.0056 15.3 9.1 0.0079 14.8 9.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2163 PF09931.9 EWC47505.1 - 0.088 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2163) Pro-kuma_activ PF09286.11 EWC47506.1 - 2.7e-20 73.1 0.0 5.6e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain tRNA_int_endo PF01974.17 EWC47507.1 - 1.4e-19 69.9 0.2 2.7e-19 69.0 0.2 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EWC47507.1 - 0.00011 21.8 0.0 0.001 18.7 0.0 2.2 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Ribosomal_L27 PF01016.19 EWC47509.1 - 1.9e-29 101.5 0.0 3.8e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein NOB1_Zn_bind PF08772.11 EWC47511.1 - 1.9e-28 98.4 2.8 3.3e-28 97.7 2.8 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EWC47511.1 - 1.1e-27 96.4 0.0 2.3e-27 95.3 0.0 1.6 1 0 0 1 1 1 1 PIN domain of ribonuclease zf-C3HC4_3 PF13920.6 EWC47511.1 - 0.051 13.4 1.2 0.1 12.5 1.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Rpr2 PF04032.16 EWC47511.1 - 0.069 13.4 0.2 0.17 12.2 0.2 1.6 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn-ribbon_8 PF09723.10 EWC47511.1 - 1.2 9.3 3.4 1.9 8.7 1.6 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zinc-ribbons_6 PF07191.12 EWC47511.1 - 4.5 7.3 6.5 0.23 11.5 0.9 1.7 2 0 0 2 2 2 0 zinc-ribbons Nop10p PF04135.12 EWC47512.1 - 1e-20 73.5 0.5 1.2e-20 73.2 0.5 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family WW PF00397.26 EWC47513.1 - 2e-11 43.7 5.1 4.1e-11 42.8 5.1 1.5 1 0 0 1 1 1 1 WW domain TPR_1 PF00515.28 EWC47514.1 - 0.0007 19.3 0.0 0.15 11.9 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat UBA PF00627.31 EWC47514.1 - 0.002 18.0 0.0 0.0058 16.5 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain TPR_2 PF07719.17 EWC47514.1 - 0.0021 18.1 0.2 35 4.8 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC47514.1 - 0.013 15.8 0.1 0.13 12.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DnaJ PF00226.31 EWC47514.1 - 0.14 12.3 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain PHO4 PF01384.20 EWC47517.1 - 7.6e-102 340.8 17.1 8.7e-102 340.6 17.1 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF4134 PF13572.6 EWC47517.1 - 0.5 10.7 11.5 2.2 8.6 1.9 4.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4134) UPF0444 PF15475.6 EWC47517.1 - 6.1 7.2 11.9 0.93 9.8 0.3 3.1 2 1 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 Mito_carr PF00153.27 EWC47518.1 - 3.7e-44 148.6 6.7 2.7e-16 59.3 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_61 PF03443.14 EWC47519.1 - 3.4e-56 190.4 0.0 6.1e-56 189.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EWC47519.1 - 7.1e-11 41.9 10.6 3e-10 39.9 10.6 2.2 1 0 0 1 1 1 1 Fungal cellulose binding domain Bac_export_3 PF01313.19 EWC47521.1 - 0.037 13.9 0.2 0.054 13.4 0.2 1.1 1 0 0 1 1 1 0 Bacterial export proteins, family 3 Dicty_REP PF05086.12 EWC47522.1 - 2.1 6.2 4.2 2.6 5.9 4.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AT_hook PF02178.19 EWC47522.1 - 6.7 6.9 31.9 0.12 12.3 4.8 4.1 3 0 0 3 3 3 0 AT hook motif SH3_1 PF00018.28 EWC47524.1 - 1.8e-10 40.2 0.0 3.3e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC47524.1 - 2.3e-06 27.4 0.0 4.6e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EWC47524.1 - 9.5e-05 22.0 0.0 0.00018 21.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Apt1 PF10351.9 EWC47524.1 - 0.24 10.2 6.8 0.37 9.6 6.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain PAP1 PF08601.10 EWC47524.1 - 5.5 6.6 11.5 10 5.7 11.5 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 Sugar_tr PF00083.24 EWC47526.1 - 6.9e-87 292.2 21.4 7.9e-87 292.0 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC47526.1 - 9.9e-40 136.5 42.3 3.9e-31 108.3 27.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EWC47526.1 - 3.8e-05 22.3 5.2 0.013 14.0 0.2 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF3792 PF12670.7 EWC47526.1 - 0.017 15.3 3.1 0.017 15.3 3.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) Aldo_ket_red PF00248.21 EWC47528.1 - 3.8e-67 226.5 0.0 4.4e-67 226.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Claudin_3 PF06653.11 EWC47528.1 - 0.07 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Tight junction protein, Claudin-like IF-2B PF01008.17 EWC47529.1 - 4.9e-12 45.6 0.0 1.4e-11 44.1 0.0 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family DEAD PF00270.29 EWC47530.1 - 2.8e-25 89.1 0.0 4.5e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EWC47530.1 - 2.9e-21 76.0 0.0 7.4e-21 74.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EWC47530.1 - 3.4e-13 49.9 0.1 1e-12 48.4 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47530.1 - 8.2e-06 25.9 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Wbp11 PF09429.10 EWC47532.1 - 5.9e-18 65.0 14.1 5.9e-18 65.0 14.1 1.8 2 0 0 2 2 2 1 WW domain binding protein 11 Macoilin PF09726.9 EWC47532.1 - 0.18 10.3 7.7 0.24 9.9 7.7 1.1 1 0 0 1 1 1 0 Macoilin family FmiP_Thoc5 PF09766.9 EWC47532.1 - 0.62 9.3 6.1 0.9 8.8 6.1 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF3040 PF11239.8 EWC47532.1 - 0.7 10.2 4.6 1.3 9.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF3450 PF11932.8 EWC47532.1 - 3.5 6.9 11.0 3 7.1 7.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Tyrosinase PF00264.20 EWC47533.1 - 4.7e-48 164.4 0.2 7.4e-48 163.7 0.2 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EWC47533.1 - 1.8e-29 102.9 0.0 3e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Phage_antitermQ PF06530.12 EWC47534.1 - 0.1 12.5 0.6 0.2 11.5 0.6 1.4 1 0 0 1 1 1 0 Phage antitermination protein Q AA_permease_2 PF13520.6 EWC47535.1 - 2.5e-42 145.2 20.0 3.1e-42 144.9 20.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC47535.1 - 4.6e-17 61.8 23.6 5.7e-17 61.5 23.6 1.0 1 0 0 1 1 1 1 Amino acid permease DUF5124 PF17160.4 EWC47535.1 - 0.12 13.1 0.0 0.32 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5124) tRNA-synt_1b PF00579.25 EWC47536.1 - 3.1e-42 144.9 0.0 6.2e-42 143.9 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Acetyltransf_3 PF13302.7 EWC47536.1 - 7.1e-06 26.7 0.0 2.9e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EWC47536.1 - 0.026 14.8 0.0 0.07 13.4 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family 2OG-FeII_Oxy PF03171.20 EWC47537.1 - 3.7e-12 46.6 0.0 8.8e-12 45.4 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EWC47537.1 - 2.2e-08 34.9 0.0 3.4e-08 34.3 0.0 1.4 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Haem_oxygenas_2 PF14518.6 EWC47538.1 - 5.7e-43 146.7 0.2 1e-42 145.9 0.2 1.4 1 0 0 1 1 1 1 Iron-containing redox enzyme HMGL-like PF00682.19 EWC47539.1 - 4.1e-47 161.0 0.0 4.8e-47 160.7 0.0 1.0 1 0 0 1 1 1 1 HMGL-like Diphthamide_syn PF01866.17 EWC47540.1 - 1.8e-116 388.8 0.0 2.4e-116 388.4 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Corona_3 PF04694.12 EWC47540.1 - 0.085 13.2 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Coronavirus ORF3 protein UQ_con PF00179.26 EWC47541.1 - 5.2e-10 39.1 0.0 9.5e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TerD PF02342.18 EWC47541.1 - 1.4e-08 34.5 0.0 2.3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 TerD domain F-box-like PF12937.7 EWC47541.1 - 6.3e-06 26.0 0.0 1.7e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC47541.1 - 0.0015 18.3 0.1 0.0069 16.2 0.0 2.3 2 0 0 2 2 2 1 F-box domain MFS_1 PF07690.16 EWC47542.1 - 1.8e-36 125.8 62.5 1.8e-36 125.8 62.5 3.3 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EWC47542.1 - 0.00072 18.0 19.2 0.16 10.2 19.3 3.1 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family TPR_12 PF13424.6 EWC47543.1 - 2.6e-22 78.9 11.8 6.4e-07 29.6 0.0 6.3 4 2 2 6 6 6 4 Tetratricopeptide repeat NB-ARC PF00931.22 EWC47543.1 - 2.9e-15 56.2 0.0 4.9e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_10 PF13374.6 EWC47543.1 - 2e-13 49.7 11.5 0.012 15.4 0.3 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47543.1 - 2.2e-08 33.6 13.8 0.31 11.4 0.5 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47543.1 - 3.6e-07 29.8 13.0 0.035 14.2 0.9 6.7 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47543.1 - 1.6e-06 27.7 3.4 7.1 6.6 0.3 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EWC47543.1 - 1.6e-06 27.7 6.4 0.052 12.9 0.0 3.5 2 1 1 4 4 4 3 MalT-like TPR region AAA_16 PF13191.6 EWC47543.1 - 2.2e-05 24.9 0.0 9.6e-05 22.8 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EWC47543.1 - 2.3e-05 24.4 0.0 8.7e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea TPR_19 PF14559.6 EWC47543.1 - 0.00039 20.9 9.7 0.63 10.6 0.0 5.7 4 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EWC47543.1 - 0.00058 19.7 9.0 0.6 10.3 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EWC47543.1 - 0.00066 19.9 3.1 9.9 6.8 0.0 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat Goodbye PF17109.5 EWC47543.1 - 0.00086 19.7 0.0 0.004 17.6 0.0 2.2 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain TPR_14 PF13428.6 EWC47543.1 - 0.0013 19.4 17.5 0.21 12.5 0.2 6.4 7 0 0 7 7 6 2 Tetratricopeptide repeat Cas_Cas02710 PF09670.10 EWC47543.1 - 0.0046 15.8 1.7 0.15 10.8 0.0 2.4 1 1 1 2 2 2 1 CRISPR-associated protein (Cas_Cas02710) ANAPC3 PF12895.7 EWC47543.1 - 0.0048 17.1 0.2 10 6.4 0.0 3.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 EWC47543.1 - 0.0097 16.1 3.0 6.9 7.2 0.0 4.8 5 0 0 5 5 4 1 PPR repeat TPR_4 PF07721.14 EWC47543.1 - 0.032 14.8 9.3 2.3 9.1 0.5 4.9 5 0 0 5 5 3 0 Tetratricopeptide repeat AAA_22 PF13401.6 EWC47543.1 - 0.048 13.9 0.0 0.54 10.5 0.0 2.7 3 0 0 3 3 2 0 AAA domain TPR_16 PF13432.6 EWC47543.1 - 0.36 11.5 7.1 13 6.5 0.2 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EWC47543.1 - 2.3 8.0 5.6 39 4.0 0.8 3.7 4 0 0 4 4 4 0 TPR repeat Ribosomal_L28 PF00830.19 EWC47544.1 - 1.7e-17 63.4 0.5 3.6e-17 62.3 0.5 1.6 1 0 0 1 1 1 1 Ribosomal L28 family HARP PF07443.13 EWC47544.1 - 1.2 8.9 3.4 22 4.8 0.0 3.1 2 1 0 2 2 2 0 HepA-related protein (HARP) Sm_multidrug_ex PF06695.11 EWC47545.1 - 0.036 14.7 0.9 4.9 7.8 0.0 3.2 3 0 0 3 3 3 0 Putative small multi-drug export protein DUF2116 PF09889.9 EWC47545.1 - 0.039 13.9 0.5 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) LapA_dom PF06305.11 EWC47545.1 - 0.8 9.6 6.2 6.8 6.6 0.1 3.1 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Baculo_PEP_C PF04513.12 EWC47545.1 - 3 7.9 7.5 15 5.6 0.1 3.5 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ATP-synt_C PF00137.21 EWC47545.1 - 4 7.9 8.1 26 5.3 2.9 3.0 3 0 0 3 3 3 0 ATP synthase subunit C PAPA-1 PF04795.12 EWC47547.1 - 2.8e-27 95.3 6.0 2.8e-27 95.3 6.0 3.7 3 2 0 3 3 3 1 PAPA-1-like conserved region Rgp1 PF08737.10 EWC47548.1 - 1.9e-142 475.3 0.0 4.5e-142 474.1 0.0 1.6 2 0 0 2 2 2 1 Rgp1 Arrestin_C PF02752.22 EWC47548.1 - 0.00062 20.2 0.1 0.6 10.6 0.0 3.2 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EWC47548.1 - 0.0043 17.1 0.1 0.0084 16.2 0.1 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain TPPII_N PF12583.8 EWC47548.1 - 3.4 8.3 6.3 11 6.6 6.3 1.8 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal RFC1 PF08519.12 EWC47549.1 - 2.8e-55 186.8 0.0 1.6e-54 184.3 0.0 2.2 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EWC47549.1 - 1.2e-13 51.2 0.0 3.5e-13 49.7 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EWC47549.1 - 9.8e-11 42.2 0.0 5.2e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EWC47549.1 - 1.4e-07 31.6 0.1 3.2e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EWC47549.1 - 0.00012 22.4 0.0 0.00034 20.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EWC47549.1 - 0.00034 21.1 0.0 0.0013 19.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EWC47549.1 - 0.00035 20.7 0.0 0.00092 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EWC47549.1 - 0.00053 20.4 0.0 0.0033 17.8 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EWC47549.1 - 0.0022 18.0 0.0 0.0093 16.0 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EWC47549.1 - 0.0085 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EWC47549.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain BRCT_2 PF16589.5 EWC47549.1 - 0.024 15.0 0.2 0.17 12.3 0.0 2.3 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain DNA_pol3_delta PF06144.13 EWC47549.1 - 0.029 14.1 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III, delta subunit ABC_tran PF00005.27 EWC47549.1 - 0.036 14.6 0.2 7.3 7.1 0.0 2.9 2 0 0 2 2 2 0 ABC transporter PTCB-BRCT PF12738.7 EWC47549.1 - 0.04 13.9 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain NACHT PF05729.12 EWC47549.1 - 0.068 13.1 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 EWC47549.1 - 0.077 13.2 0.0 0.22 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EWC47549.1 - 0.097 13.1 0.0 0.097 13.1 0.0 2.3 2 1 0 2 2 1 0 RNA helicase SAGA-Tad1 PF12767.7 EWC47549.1 - 0.11 12.3 0.0 0.11 12.3 0.0 2.9 2 2 0 2 2 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Sigma54_activat PF00158.26 EWC47549.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EWC47549.1 - 0.13 12.1 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 EWC47549.1 - 0.13 12.2 0.0 0.47 10.5 0.0 2.0 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 EWC47549.1 - 0.72 9.6 0.0 0.72 9.6 0.0 3.2 4 0 0 4 4 3 0 AAA domain BLOC1_2 PF10046.9 EWC47550.1 - 2.8e-09 37.2 0.0 3.3e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 GrpE PF01025.19 EWC47551.1 - 9.8e-47 158.7 1.0 1.2e-46 158.4 1.0 1.1 1 0 0 1 1 1 1 GrpE PUMA PF15826.5 EWC47551.1 - 0.015 15.5 1.9 0.024 14.8 1.9 1.2 1 0 0 1 1 1 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis ATG16 PF08614.11 EWC47551.1 - 0.13 12.5 3.5 0.16 12.2 3.5 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Hamartin PF04388.12 EWC47551.1 - 0.15 10.7 3.5 0.17 10.5 3.5 1.0 1 0 0 1 1 1 0 Hamartin protein DUF1492 PF07374.11 EWC47551.1 - 0.2 11.8 0.3 0.33 11.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) DUF3306 PF11748.8 EWC47551.1 - 0.91 10.4 7.2 1.5 9.7 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF3597 PF12200.8 EWC47551.1 - 1.1 9.8 8.4 1.7 9.2 7.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3597) tRNA-synt_2d PF01409.20 EWC47552.1 - 3.8e-51 173.9 0.1 3e-26 92.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EWC47552.1 - 4.4e-25 87.9 0.0 1.1e-24 86.7 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DUF2563 PF10817.8 EWC47552.1 - 0.15 12.7 0.2 0.45 11.2 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2563) KH_1 PF00013.29 EWC47553.1 - 8.5e-49 163.3 13.5 1.1e-16 60.4 1.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EWC47553.1 - 4.9e-10 39.1 8.0 0.014 15.2 1.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EWC47553.1 - 1.4e-08 34.5 12.5 0.0028 17.5 0.1 3.9 4 0 0 4 4 4 3 KH domain KH_5 PF13184.6 EWC47553.1 - 8.5e-05 22.6 5.7 0.51 10.5 0.4 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 EWC47553.1 - 0.0022 18.0 0.0 3.3 7.8 0.0 2.9 3 0 0 3 3 3 2 KH-like RNA-binding domain GRP PF07172.11 EWC47553.1 - 0.006 17.2 53.8 0.43 11.3 7.9 2.9 2 0 0 2 2 2 2 Glycine rich protein family zf-MYND PF01753.18 EWC47555.1 - 0.32 11.1 10.7 0.59 10.3 10.7 1.4 1 0 0 1 1 1 0 MYND finger Unstab_antitox PF09720.10 EWC47556.1 - 0.023 14.7 0.1 0.045 13.8 0.1 1.4 1 0 0 1 1 1 0 Putative addiction module component WD40 PF00400.32 EWC47557.1 - 7.4e-19 67.8 12.3 0.013 16.3 0.0 9.4 10 0 0 10 10 10 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47557.1 - 0.00034 20.8 2.0 50 4.3 0.1 5.6 6 0 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain NUC173 PF08161.12 EWC47558.1 - 4.3e-77 258.4 0.2 1.3e-70 237.3 0.0 3.7 3 0 0 3 3 3 2 NUC173 domain HEAT PF02985.22 EWC47558.1 - 0.0045 17.1 2.5 2.6 8.6 0.0 4.6 5 0 0 5 5 5 2 HEAT repeat RecT PF03837.14 EWC47558.1 - 0.46 9.9 1.7 0.53 9.7 0.5 1.6 2 0 0 2 2 2 0 RecT family HEAT_EZ PF13513.6 EWC47558.1 - 0.48 11.0 8.0 39 4.9 0.0 5.7 6 0 0 6 6 6 0 HEAT-like repeat Peptidase_S8 PF00082.22 EWC47559.1 - 0.031 13.5 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Subtilase family Mito_carr PF00153.27 EWC47560.1 - 2.1e-60 200.7 0.1 1.7e-23 82.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.21 EWC47561.1 - 3.3e-20 72.5 0.0 4.8e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 EWC47562.1 - 4.9e-18 65.2 39.1 1.3e-11 44.1 24.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC47562.1 - 1.3e-14 53.9 17.0 6.3e-12 45.1 17.0 2.8 1 1 0 1 1 1 1 Sugar (and other) transporter PAP2 PF01569.21 EWC47563.1 - 8e-21 74.2 1.8 1.9e-20 73.0 1.8 1.6 1 0 0 1 1 1 1 PAP2 superfamily Calcipressin PF04847.12 EWC47564.1 - 4.5e-43 147.2 0.3 7.3e-43 146.5 0.3 1.3 1 1 0 1 1 1 1 Calcipressin AAA PF00004.29 EWC47565.1 - 7.1e-39 133.3 0.0 1.6e-38 132.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC47565.1 - 2.7e-07 30.3 0.6 2.7e-07 30.3 0.6 2.0 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 EWC47565.1 - 4.9e-05 23.1 0.0 0.00014 21.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EWC47565.1 - 0.0001 22.7 2.3 0.0017 18.8 0.1 3.3 2 1 0 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 EWC47565.1 - 0.0001 21.6 0.3 0.00034 19.9 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 EWC47565.1 - 0.00057 20.1 0.0 0.0023 18.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 EWC47565.1 - 0.0017 18.6 0.2 0.057 13.7 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EWC47565.1 - 0.0018 18.3 0.0 0.0044 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EWC47565.1 - 0.0058 16.9 0.0 0.027 14.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EWC47565.1 - 0.0063 17.1 0.5 0.04 14.5 0.0 2.6 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.17 EWC47565.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 EWC47565.1 - 0.016 15.3 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EWC47565.1 - 0.027 13.8 0.1 0.072 12.5 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EWC47565.1 - 0.036 14.5 0.0 0.076 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 EWC47565.1 - 0.048 14.1 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EWC47565.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EWC47565.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IPT PF01745.16 EWC47565.1 - 0.2 11.0 0.0 0.37 10.2 0.0 1.3 1 0 0 1 1 1 0 Isopentenyl transferase Parvo_NS1 PF01057.17 EWC47565.1 - 0.22 10.6 0.0 0.47 9.5 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PP_M1 PF03012.14 EWC47565.1 - 0.33 10.5 1.5 9.8 5.6 0.0 2.8 3 0 0 3 3 3 0 Phosphoprotein Glyco_transf_34 PF05637.12 EWC47566.1 - 1.6e-46 159.0 0.0 6e-46 157.1 0.0 1.9 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF1643 PF07799.12 EWC47566.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) HMGL-like PF00682.19 EWC47567.1 - 2e-80 270.1 0.4 3.4e-80 269.4 0.4 1.3 1 0 0 1 1 1 1 HMGL-like DUF3666 PF12408.8 EWC47567.1 - 0.23 10.7 1.3 0.46 9.7 0.3 2.0 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase WD40 PF00400.32 EWC47568.1 - 9.8e-25 86.4 6.8 1.9e-06 28.5 0.1 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47568.1 - 6.8e-16 58.4 4.8 0.011 16.0 0.0 6.1 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EWC47568.1 - 1.8e-07 30.9 0.0 5.4e-07 29.3 0.0 1.9 1 0 0 1 1 1 1 LisH VID27 PF08553.10 EWC47568.1 - 0.00017 20.8 0.0 0.034 13.2 0.0 2.2 2 0 0 2 2 2 2 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 EWC47568.1 - 0.0054 15.7 0.0 1.5 7.7 0.0 3.4 2 2 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EWC47568.1 - 0.017 13.8 0.8 1.6 7.3 0.0 2.9 2 1 0 2 2 2 0 Nucleoporin Nup120/160 eIF2A PF08662.11 EWC47568.1 - 0.041 13.8 0.1 1.4 8.7 0.0 3.1 3 2 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A Vps16_N PF04841.13 EWC47568.1 - 0.045 12.5 0.0 0.2 10.3 0.0 1.8 1 1 1 2 2 2 0 Vps16, N-terminal region IKI3 PF04762.12 EWC47568.1 - 0.052 11.5 1.2 0.2 9.6 0.3 2.0 2 0 0 2 2 2 0 IKI3 family CtaG_Cox11 PF04442.14 EWC47569.1 - 5.4e-60 201.8 0.1 6.8e-60 201.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 zf-HIT PF04438.16 EWC47570.1 - 3.8e-09 36.3 12.3 7.2e-09 35.4 12.3 1.4 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.24 EWC47570.1 - 0.0038 17.3 7.4 0.0059 16.7 7.4 1.3 1 0 0 1 1 1 1 B-box zinc finger zf-MYND PF01753.18 EWC47570.1 - 0.037 14.1 12.4 0.061 13.4 12.4 1.3 1 0 0 1 1 1 0 MYND finger COX6B PF02297.17 EWC47572.1 - 2.3e-18 66.2 5.5 2.6e-18 66.0 5.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.14 EWC47572.1 - 0.015 15.2 1.7 0.017 15.1 1.3 1.4 1 1 0 1 1 1 0 APOBEC-like C-terminal domain CX9C PF16860.5 EWC47572.1 - 0.029 14.4 2.4 0.048 13.7 2.4 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UPF0203 PF05254.12 EWC47572.1 - 0.3 11.4 5.5 0.7 10.2 1.5 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) DUF1741 PF08427.10 EWC47573.1 - 1.6e-77 260.3 0.0 2e-77 260.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) DNA_pol3_delta2 PF13177.6 EWC47575.1 - 7.4e-10 38.8 0.2 1.6e-09 37.8 0.2 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EWC47575.1 - 1.7e-06 28.3 0.1 3.3e-05 24.2 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EWC47575.1 - 7.8e-06 26.4 1.3 0.0011 19.4 0.4 3.0 2 2 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EWC47575.1 - 1.1e-05 25.9 0.2 2.3e-05 24.9 0.2 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EWC47575.1 - 5.1e-05 23.6 0.3 0.00019 21.8 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain Resolvase PF00239.21 EWC47575.1 - 0.0019 18.3 0.1 0.96 9.6 0.2 2.3 2 0 0 2 2 2 2 Resolvase, N terminal domain Sigma54_activ_2 PF14532.6 EWC47575.1 - 0.0025 17.9 0.2 0.34 11.0 0.2 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_24 PF13479.6 EWC47575.1 - 0.0029 17.4 0.6 0.0096 15.7 0.6 1.8 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EWC47575.1 - 0.003 17.5 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain T4SS-DNA_transf PF02534.14 EWC47575.1 - 0.03 13.2 0.0 0.053 12.3 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer ABC_tran PF00005.27 EWC47575.1 - 0.1 13.1 0.1 0.23 12.0 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 EWC47575.1 - 0.11 12.5 0.3 0.34 10.9 0.3 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LIM_bind PF01803.16 EWC47576.1 - 4.2e-68 229.5 0.1 4.2e-68 229.5 0.1 5.6 4 1 0 4 4 4 2 LIM-domain binding protein Peptidase_S46 PF10459.9 EWC47576.1 - 0.0017 17.1 32.9 0.0017 17.1 32.9 1.9 2 0 0 2 2 2 1 Peptidase S46 EIF4E-T PF10477.9 EWC47576.1 - 0.82 8.4 64.0 0.95 8.2 4.7 2.6 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E cobW PF02492.19 EWC47577.1 - 4.6e-34 117.5 0.0 5.6e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 EWC47577.1 - 0.0018 18.3 0.0 0.006 16.7 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 EWC47577.1 - 0.0021 17.1 0.1 0.71 8.8 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB ResIII PF04851.15 EWC47577.1 - 0.072 13.1 0.0 0.093 12.7 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 EWC47577.1 - 0.14 12.7 0.1 0.34 11.4 0.1 1.6 2 1 0 2 2 2 0 AAA domain TIP49 PF06068.13 EWC47577.1 - 0.16 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Pox_A32 PF04665.12 EWC47577.1 - 0.16 11.4 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein TMEM51 PF15345.6 EWC47577.1 - 0.23 11.3 0.0 0.32 10.8 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 NUDIX PF00293.28 EWC47578.1 - 1.3e-17 64.1 0.3 1.6e-17 63.8 0.3 1.1 1 0 0 1 1 1 1 NUDIX domain DUF3693 PF12472.8 EWC47578.1 - 1.1 9.0 3.7 2.2 8.0 3.7 1.4 1 0 0 1 1 1 0 Phage related protein NAD_binding_4 PF07993.12 EWC47579.1 - 2.2e-72 243.3 0.0 3.3e-72 242.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EWC47579.1 - 2.3e-67 227.4 0.0 3.5e-67 226.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EWC47579.1 - 1.6e-12 47.6 0.0 3.6e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EWC47579.1 - 1.5e-10 41.0 0.0 3.4e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Condensation PF00668.20 EWC47579.1 - 8.2e-08 31.3 0.0 1.3e-06 27.4 0.0 2.3 1 1 0 1 1 1 1 Condensation domain AMP-binding_C PF13193.6 EWC47579.1 - 1.6e-05 25.8 0.1 7.3e-05 23.7 0.1 2.3 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 EWC47579.1 - 0.0017 17.4 0.0 0.0053 15.8 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EWC47579.1 - 0.022 14.7 0.0 0.38 10.6 0.0 2.5 1 1 0 1 1 1 0 NAD(P)H-binding Chorismate_bind PF00425.18 EWC47580.1 - 8.6e-95 317.2 0.0 1.3e-94 316.6 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EWC47580.1 - 2.5e-33 115.3 0.0 4.4e-28 98.3 0.0 3.6 3 1 0 3 3 3 2 Anthranilate synthase component I, N terminal region POR PF01558.18 EWC47580.1 - 0.13 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Ribosomal_L16 PF00252.18 EWC47581.1 - 8.2e-33 113.2 0.4 1.3e-32 112.6 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e bMG6 PF17962.1 EWC47581.1 - 0.074 13.2 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Bacterial macroglobulin domain 6 ATE_C PF04377.15 EWC47582.1 - 1.6e-44 151.7 1.3 2.7e-44 151.0 1.3 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EWC47582.1 - 1.1e-22 80.1 0.3 3.1e-22 78.7 0.3 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Fer2 PF00111.27 EWC47582.1 - 0.025 14.5 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Acetyltransf_6 PF13480.7 EWC47582.1 - 0.12 12.5 1.9 0.28 11.3 1.9 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain WD40 PF00400.32 EWC47585.1 - 2.3e-08 34.5 0.1 1 10.4 0.1 5.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Sec16_C PF12931.7 EWC47585.1 - 1.1e-05 25.3 0.4 8.3e-05 22.4 0.4 2.1 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 ANAPC4_WD40 PF12894.7 EWC47585.1 - 0.01 16.1 0.3 9.8 6.6 0.4 3.8 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 EWC47585.1 - 0.097 11.6 0.0 11 4.8 0.0 2.5 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain SOG2 PF10428.9 EWC47585.1 - 7.6 5.6 9.7 11 5.1 9.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein HLH PF00010.26 EWC47587.1 - 8.9e-07 28.8 0.0 1.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain GET2 PF08690.10 EWC47588.1 - 6.9e-21 75.2 0.5 2.3e-20 73.5 0.5 1.9 1 1 0 1 1 1 1 GET complex subunit GET2 CCDC84 PF14968.6 EWC47588.1 - 0.0095 15.6 0.5 0.014 15.1 0.5 1.2 1 0 0 1 1 1 1 Coiled coil protein 84 TetR_C_33 PF13305.6 EWC47588.1 - 0.15 12.8 1.3 3 8.7 0.8 2.6 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain L51_S25_CI-B8 PF05047.16 EWC47589.1 - 6.8e-11 41.9 0.0 1.4e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CENP-Q PF13094.6 EWC47590.1 - 1.4e-26 93.7 8.0 1.4e-26 93.7 8.0 1.8 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Peptidase_S49 PF01343.18 EWC47590.1 - 0.079 12.9 0.7 0.17 11.8 0.2 1.8 1 1 1 2 2 2 0 Peptidase family S49 AAA_23 PF13476.6 EWC47590.1 - 0.38 11.2 5.3 0.66 10.4 5.3 1.4 1 0 0 1 1 1 0 AAA domain CENP-H PF05837.12 EWC47590.1 - 0.59 10.6 8.7 0.88 10.0 3.7 2.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) SAPS PF04499.15 EWC47591.1 - 0.69 8.6 2.6 0.8 8.4 2.6 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PAS PF00989.25 EWC47592.1 - 0.11 12.4 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 PAS fold YvrJ PF12841.7 EWC47593.1 - 0.032 13.8 0.5 5.6 6.6 0.3 2.2 2 0 0 2 2 2 0 YvrJ protein family Sec6 PF06046.13 EWC47594.1 - 2e-133 445.8 0.5 2.9e-133 445.3 0.5 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.12 EWC47594.1 - 0.0052 15.8 0.8 0.0052 15.8 0.8 1.6 2 0 0 2 2 2 1 Vps53-like, N-terminal FlgT_N PF16548.5 EWC47594.1 - 0.075 13.6 0.7 0.54 10.9 0.2 2.7 1 1 1 2 2 2 0 Flagellar assembly protein T, N-terminal domain Vps54_N PF10475.9 EWC47594.1 - 0.11 11.8 1.3 0.29 10.4 1.3 1.6 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex NPV_P10 PF05531.12 EWC47594.1 - 2.5 8.6 10.1 18 5.9 6.5 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Ribosomal_L30 PF00327.20 EWC47595.1 - 1.2e-16 60.3 0.4 1.8e-16 59.8 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF969 PF06149.12 EWC47595.1 - 0.024 14.1 0.1 0.027 13.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF969) Med30 PF11315.8 EWC47595.1 - 0.085 13.1 0.0 0.096 12.9 0.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 30 Pyridoxal_deC PF00282.19 EWC47596.1 - 1.3e-21 76.8 0.0 2e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EWC47596.1 - 3.1e-10 39.5 0.0 5.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EWC47596.1 - 0.00011 21.6 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Asp PF00026.23 EWC47597.1 - 2.2e-12 47.1 0.1 2.6e-06 27.1 0.2 2.1 1 1 1 2 2 2 2 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EWC47597.1 - 0.17 12.6 1.2 0.72 10.5 0.0 2.7 3 0 0 3 3 3 0 Aspartyl protease DUF4050 PF13259.6 EWC47598.1 - 4.8e-31 108.5 3.5 6.3e-19 69.0 0.1 4.5 2 2 1 3 3 3 2 Protein of unknown function (DUF4050) DUF4851 PF16143.5 EWC47598.1 - 0.013 14.9 0.5 0.023 14.2 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4851) FAM176 PF14851.6 EWC47598.1 - 8.3 6.1 7.6 18 5.0 7.5 1.7 1 1 0 1 1 1 0 FAM176 family SNAP PF14938.6 EWC47599.1 - 1e-86 290.9 16.0 1.2e-86 290.7 16.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 EWC47599.1 - 0.0016 19.0 10.5 23 5.9 0.1 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat Hep_59 PF07052.11 EWC47599.1 - 0.065 14.0 0.2 0.12 13.1 0.2 1.5 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 TPR_12 PF13424.6 EWC47599.1 - 0.07 13.4 12.5 0.49 10.7 1.5 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47599.1 - 0.12 12.6 20.5 1.1 9.6 0.1 5.7 6 1 1 7 7 7 0 Tetratricopeptide repeat Glyco_hydro_9 PF00759.19 EWC47599.1 - 1.7 8.0 10.6 2.3 7.6 9.6 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 9 Glu-tRNAGln PF02686.15 EWC47600.1 - 3e-09 37.0 0.7 5.1e-09 36.3 0.7 1.3 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit TruB_C_2 PF16198.5 EWC47600.1 - 0.09 12.9 0.0 1.3 9.2 0.0 2.2 1 1 1 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain Tetraspanin PF00335.20 EWC47601.1 - 0.0027 17.4 0.0 0.0041 16.8 0.0 1.4 1 1 0 1 1 1 1 Tetraspanin family Cytochrom_C PF00034.21 EWC47602.1 - 5.9e-12 46.6 0.0 8.5e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EWC47602.1 - 2.4e-09 37.3 0.6 3.8e-08 33.5 0.6 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EWC47602.1 - 0.0037 17.0 0.9 0.022 14.5 0.9 2.2 1 1 0 1 1 1 1 Cytochrome c-550 domain CCP_MauG PF03150.14 EWC47602.1 - 0.083 13.5 0.0 0.091 13.4 0.0 1.2 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase Docking PF08990.11 EWC47602.1 - 0.27 10.9 1.1 0.94 9.2 0.4 1.9 2 0 0 2 2 2 0 Erythronolide synthase docking zf-Tim10_DDP PF02953.15 EWC47604.1 - 4.2e-22 77.6 0.4 5.2e-22 77.3 0.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF3398 PF11878.8 EWC47604.1 - 0.028 14.8 0.1 0.029 14.8 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3398) Cyclin_N PF00134.23 EWC47605.1 - 3.6e-07 30.0 0.0 6.6e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Actino_peptide PF14408.6 EWC47605.1 - 0.16 12.1 2.2 11 6.2 0.0 2.6 2 0 0 2 2 2 0 Ribosomally synthesised peptide in actinomycetes DUF5402 PF17393.2 EWC47605.1 - 0.24 11.4 0.2 0.45 10.5 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5402) ADH_N PF08240.12 EWC47606.1 - 3.8e-34 116.8 1.5 2e-33 114.5 2.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC47606.1 - 1.9e-15 57.0 0.0 3e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EWC47606.1 - 2.5e-12 46.8 0.0 3.8e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EWC47606.1 - 2.9e-07 31.6 0.0 5.1e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 EWC47606.1 - 0.0042 16.4 0.3 0.0073 15.6 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 EWC47606.1 - 0.012 16.0 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 EWC47606.1 - 0.022 15.0 0.0 0.038 14.3 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF2318 PF10080.9 EWC47606.1 - 0.057 13.5 0.9 21 5.3 0.8 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) XdhC_C PF13478.6 EWC47606.1 - 0.15 12.6 0.0 0.24 11.9 0.0 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain RCC1 PF00415.18 EWC47607.1 - 3.1e-07 30.9 8.9 0.0046 17.5 0.1 4.9 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EWC47607.1 - 0.018 14.8 15.9 0.022 14.5 0.1 4.9 5 0 0 5 5 5 0 Regulator of chromosome condensation (RCC1) repeat TetR_C_31 PF17940.1 EWC47607.1 - 0.11 12.7 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RasGEF PF00617.19 EWC47609.1 - 3.1e-45 154.5 0.0 1.6e-44 152.3 0.1 2.2 2 0 0 2 2 2 1 RasGEF domain Ras PF00071.22 EWC47609.1 - 1.8e-07 30.9 0.1 1.7e-06 27.7 0.1 2.2 1 1 0 1 1 1 1 Ras family RasGEF_N PF00618.20 EWC47609.1 - 3.1e-05 24.2 0.0 9.7e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif RsgA_GTPase PF03193.16 EWC47609.1 - 0.0025 17.7 0.1 1 9.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 EWC47609.1 - 0.003 17.1 0.0 0.0072 15.8 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 EWC47609.1 - 0.038 13.5 0.1 0.71 9.4 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EWC47609.1 - 0.14 12.2 0.1 0.53 10.4 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase PSP1 PF04468.12 EWC47610.1 - 3.5e-27 94.5 3.1 6.4e-27 93.7 3.1 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF1510 PF07423.11 EWC47611.1 - 0.17 12.1 0.0 0.39 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) Ribosomal_L15e PF00827.17 EWC47612.1 - 2.2e-87 291.7 11.2 3.8e-87 290.9 11.2 1.3 1 0 0 1 1 1 1 Ribosomal L15 HECT PF00632.25 EWC47614.1 - 3.9e-72 243.3 0.0 5.9e-72 242.7 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ribosomal_S30AE PF02482.19 EWC47614.1 - 0.19 12.5 0.1 0.41 11.5 0.1 1.5 1 0 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein Nfu_N PF08712.11 EWC47615.1 - 2.3e-32 110.9 0.0 1.1e-31 108.7 0.0 2.0 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EWC47615.1 - 1.3e-25 89.3 0.1 1.9e-25 88.8 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain DUF2407_C PF13373.6 EWC47616.1 - 5.2e-34 117.4 0.1 7.3e-34 116.9 0.1 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EWC47616.1 - 1.6e-16 60.7 0.0 2.7e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EWC47616.1 - 3.6e-05 23.4 0.0 6.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Fe-S_biosyn PF01521.20 EWC47617.1 - 1.4e-20 73.5 0.0 1.7e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Acetyltransf_10 PF13673.7 EWC47618.1 - 5.7e-09 36.0 0.0 7.3e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EWC47618.1 - 4.6e-07 30.1 0.0 5.8e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EWC47618.1 - 7.6e-07 29.5 0.0 9.8e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EWC47618.1 - 5.8e-06 26.4 0.0 6.8e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EWC47618.1 - 0.025 14.7 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Pyridoxal_deC PF00282.19 EWC47619.1 - 1.3e-07 30.7 0.0 0.0004 19.2 0.0 2.4 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Dynactin PF12455.8 EWC47620.1 - 4.3e-94 315.0 12.2 4.3e-94 315.0 12.2 4.0 4 1 1 5 5 5 1 Dynein associated protein CAP_GLY PF01302.25 EWC47620.1 - 1.6e-20 72.8 1.6 2.7e-20 72.1 1.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF677 PF05055.12 EWC47620.1 - 8e-05 21.7 5.5 8e-05 21.7 5.5 3.9 4 0 0 4 4 4 1 Protein of unknown function (DUF677) Peptidase_M54 PF07998.11 EWC47620.1 - 0.11 12.4 0.1 0.41 10.6 0.1 1.9 1 0 0 1 1 1 0 Peptidase family M54 F_actin_bind PF08919.10 EWC47620.1 - 0.88 9.7 21.9 0.6 10.2 0.1 5.0 4 2 0 5 5 5 0 F-actin binding PKcGMP_CC PF16808.5 EWC47620.1 - 1.1 9.2 17.3 11 5.9 0.2 6.0 4 1 1 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ZZ PF00569.17 EWC47622.1 - 5.1e-06 26.2 6.1 1.2e-05 25.0 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type PGAP1 PF07819.13 EWC47622.1 - 0.0002 21.1 0.0 0.00034 20.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EWC47622.1 - 0.014 16.0 0.0 0.036 14.7 0.0 1.8 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC47622.1 - 0.02 14.2 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 EWC47622.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) POT1PC PF16686.5 EWC47622.1 - 0.13 12.1 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 ssDNA-binding domain of telomere protection protein Dabb PF07876.12 EWC47623.1 - 1.7e-19 70.2 0.0 1.9e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain RNA_pol_A_bac PF01000.26 EWC47624.1 - 5.2e-32 110.5 0.0 7.7e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EWC47624.1 - 5.1e-20 70.7 0.0 6.6e-20 70.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Asp PF00026.23 EWC47625.1 - 6.1e-07 29.2 0.0 1.4e-05 24.7 0.0 2.2 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Methyltransf_23 PF13489.6 EWC47626.1 - 8.2e-20 71.3 0.0 1.3e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC47626.1 - 1.5e-11 44.8 0.0 4.9e-11 43.2 0.0 1.9 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC47626.1 - 1.8e-10 41.3 0.0 3.8e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC47626.1 - 1.6e-08 34.5 0.0 0.00045 20.0 0.0 2.7 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 EWC47626.1 - 5e-07 30.4 0.0 9.5e-06 26.3 0.0 2.9 3 1 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC47626.1 - 0.0036 16.7 0.0 0.079 12.3 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EWC47626.1 - 0.016 15.3 0.0 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EWC47626.1 - 0.029 13.7 0.0 0.12 11.7 0.0 1.9 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_8 PF05148.15 EWC47626.1 - 0.038 13.8 0.0 0.38 10.5 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase MTS PF05175.14 EWC47626.1 - 0.078 12.5 0.0 0.32 10.5 0.0 1.9 3 0 0 3 3 3 0 Methyltransferase small domain Halo_GVPC PF05465.13 EWC47626.1 - 0.17 12.2 0.3 0.17 12.2 0.3 2.0 2 0 0 2 2 1 0 Halobacterial gas vesicle protein C (GVPC) repeat Rxt3 PF08642.10 EWC47627.1 - 4.6e-27 95.3 0.3 7.1e-26 91.5 0.0 2.6 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EWC47627.1 - 0.094 12.8 0.0 3.5 7.8 0.0 2.4 1 1 1 2 2 2 0 LCCL domain NAD_binding_10 PF13460.6 EWC47628.1 - 2.1e-22 79.9 0.6 3.5e-22 79.2 0.6 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EWC47628.1 - 0.0075 15.8 0.0 0.0097 15.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF726 PF05277.12 EWC47629.1 - 2.5e-104 348.9 14.6 1.2e-90 303.9 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.7 EWC47629.1 - 0.04 14.5 0.2 0.04 14.5 0.2 2.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family Glyco_transf_15 PF01793.16 EWC47630.1 - 1e-117 393.1 0.4 1.2e-117 392.8 0.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase GCN5L1 PF06320.13 EWC47631.1 - 4.9e-29 100.8 2.5 5.5e-29 100.6 2.5 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) DUF2205 PF10224.9 EWC47631.1 - 0.018 15.0 0.7 0.029 14.4 0.7 1.5 1 0 0 1 1 1 0 Short coiled-coil protein Csm1_N PF18504.1 EWC47631.1 - 0.047 14.0 1.3 0.047 14.0 1.3 1.6 2 0 0 2 2 2 0 Csm1 N-terminal domain Ubiquitin_3 PF14836.6 EWC47631.1 - 0.12 12.3 0.4 0.21 11.6 0.2 1.5 1 1 0 1 1 1 0 Ubiquitin-like domain Syntaxin-6_N PF09177.11 EWC47631.1 - 0.72 10.4 5.0 1.7 9.2 1.3 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Gon7 PF08738.10 EWC47632.1 - 7e-12 45.4 7.9 4.7e-11 42.7 7.9 2.3 1 1 0 1 1 1 1 Gon7 family Cwf_Cwc_15 PF04889.12 EWC47632.1 - 0.018 14.8 6.6 0.021 14.6 6.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Met_asp_mut_E PF06368.11 EWC47632.1 - 0.065 11.7 0.3 0.078 11.4 0.3 1.0 1 0 0 1 1 1 0 Methylaspartate mutase E chain (MutE) VIR_N PF15912.5 EWC47632.1 - 1.4 8.5 8.6 1.6 8.2 8.6 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal CLN3 PF02487.17 EWC47633.1 - 1.2e-149 498.7 7.0 2.2e-149 497.9 7.0 1.4 1 0 0 1 1 1 1 CLN3 protein DUF3638 PF12340.8 EWC47633.1 - 1.4e-89 299.3 0.1 2.5e-89 298.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EWC47633.1 - 1.1e-12 47.1 0.3 4.6e-12 45.1 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) MFS_1 PF07690.16 EWC47633.1 - 2.4 7.0 28.4 1.9 7.3 26.4 1.8 1 1 0 1 1 1 0 Major Facilitator Superfamily Vps39_2 PF10367.9 EWC47634.1 - 1.8e-32 112.0 0.0 3.7e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 EWC47634.1 - 2.7e-30 104.8 0.3 3.1e-29 101.4 0.0 2.9 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 EWC47634.1 - 7.5e-29 101.2 0.0 1.1e-28 100.6 0.0 1.2 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.20 EWC47634.1 - 9.2e-07 28.8 2.2 0.011 15.7 0.0 3.0 3 0 0 3 3 3 2 Region in Clathrin and VPS TPR_7 PF13176.6 EWC47634.1 - 0.0016 18.3 2.5 11 6.4 0.1 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47634.1 - 0.0017 18.3 0.3 33 4.9 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47634.1 - 0.002 18.8 4.8 11 7.1 0.1 4.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47634.1 - 0.0056 16.5 0.1 3.2 7.7 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC47634.1 - 0.0093 16.5 0.2 0.44 11.1 0.6 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47634.1 - 0.014 16.0 0.7 3.7 8.3 0.4 3.1 2 2 0 2 2 2 0 Tetratricopeptide repeat Rad50_zn_hook PF04423.14 EWC47634.1 - 0.028 14.2 0.1 0.099 12.5 0.1 1.9 1 0 0 1 1 1 0 Rad50 zinc hook motif TPR_12 PF13424.6 EWC47634.1 - 0.051 13.9 4.2 8.9 6.7 0.7 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EWC47634.1 - 1.3 8.9 3.0 83 3.3 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Na_Ca_ex PF01699.24 EWC47635.1 - 1.9e-25 89.6 17.1 1.4e-15 57.6 8.1 2.6 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF1298 PF06974.13 EWC47635.1 - 0.074 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1298) ABC_membrane_2 PF06472.15 EWC47636.1 - 8.6e-101 336.9 0.8 1.2e-100 336.4 0.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EWC47636.1 - 8.5e-19 68.4 0.0 1.8e-18 67.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EWC47636.1 - 0.00028 20.8 0.0 0.00086 19.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EWC47636.1 - 0.0045 17.5 1.8 0.03 14.8 1.8 2.3 1 1 0 1 1 1 1 AAA domain AAA_27 PF13514.6 EWC47636.1 - 0.0061 16.2 0.0 0.031 13.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EWC47636.1 - 0.0077 15.7 0.1 0.12 11.8 0.1 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EWC47636.1 - 0.016 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cloacin_immun PF03513.14 EWC47636.1 - 0.023 15.0 0.0 0.1 13.0 0.0 2.1 2 0 0 2 2 1 0 Cloacin immunity protein Reticulon PF02453.17 EWC47636.1 - 0.055 13.4 0.4 0.11 12.5 0.4 1.4 1 0 0 1 1 1 0 Reticulon RuvB_N PF05496.12 EWC47636.1 - 0.075 12.8 0.0 0.63 9.8 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EWC47636.1 - 0.15 12.5 0.0 0.38 11.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.15 EWC47636.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain 6PF2K PF01591.18 EWC47637.1 - 4.8e-80 268.0 0.2 7.3e-80 267.5 0.2 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EWC47637.1 - 5.1e-35 120.9 0.0 1.1e-34 119.9 0.0 1.5 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EWC47637.1 - 2.8e-06 27.6 0.0 5.3e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EWC47637.1 - 6.2e-06 25.9 0.1 1e-05 25.1 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 DUF4248 PF14053.6 EWC47637.1 - 0.0063 16.5 0.1 3.4 7.8 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4248) DUF913 PF06025.12 EWC47638.1 - 5.2e-122 407.4 0.0 5.2e-122 407.4 0.0 7.0 7 1 0 7 7 7 2 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EWC47638.1 - 1.5e-100 337.1 0.1 1.5e-100 337.1 0.1 4.0 4 0 0 4 4 4 1 Domain of Unknown Function (DUF908) HECT PF00632.25 EWC47638.1 - 2.8e-95 319.3 0.2 5e-95 318.5 0.2 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EWC47638.1 - 2.4e-24 84.0 34.1 1.5e-11 43.3 1.8 4.3 4 0 0 4 4 4 3 Ubiquitin binding region UBA PF00627.31 EWC47638.1 - 4.5e-10 39.2 0.0 1.2e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain BUD22 PF09073.10 EWC47638.1 - 0.1 11.9 0.0 0.1 11.9 0.0 8.3 7 2 1 8 8 8 0 BUD22 NARP1 PF12569.8 EWC47638.1 - 3.4 6.5 29.4 0.15 10.9 5.8 2.7 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 RabGAP-TBC PF00566.18 EWC47639.1 - 3.3e-44 151.1 0.0 9.7e-44 149.6 0.0 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Cep57_CLD_2 PF14197.6 EWC47639.1 - 0.014 15.4 8.0 0.014 15.4 8.0 3.0 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 Atg14 PF10186.9 EWC47639.1 - 0.97 8.5 10.1 2 7.4 10.1 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 EWC47639.1 - 2.8 8.6 22.2 1.4 9.6 2.5 3.6 1 1 2 3 3 3 0 Initiation control protein YabA GAS PF13851.6 EWC47639.1 - 8.5 5.7 29.6 0.52 9.6 23.5 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding KfrA_N PF11740.8 EWC47640.1 - 2.5 8.8 8.9 0.086 13.5 2.0 2.0 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term PNP_UDP_1 PF01048.20 EWC47641.1 - 2e-07 30.5 0.2 4.6e-07 29.3 0.2 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily Glyco_hydro_71 PF03659.14 EWC47642.1 - 1.7e-125 418.8 2.7 2e-125 418.6 2.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 DUF4434 PF14488.6 EWC47642.1 - 0.078 13.0 0.2 0.17 11.9 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4434) EpCAM_N PF18635.1 EWC47642.1 - 0.1 12.8 3.3 0.099 12.8 1.4 2.0 2 0 0 2 2 2 0 Epithelial cell adhesion molecule N-terminal domain Mus7 PF09462.10 EWC47643.1 - 1e-95 321.9 9.0 1.4e-95 321.5 9.0 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family Fra10Ac1 PF09725.9 EWC47643.1 - 9.6e-43 145.2 0.0 1.8e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 NADase_NGA PF07461.11 EWC47643.1 - 0.17 10.7 0.0 0.33 9.8 0.0 1.3 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) SelP_N PF04592.14 EWC47643.1 - 0.85 9.0 6.1 1.7 8.0 6.1 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Abhydrolase_3 PF07859.13 EWC47644.1 - 5.7e-37 127.6 0.0 2.6e-26 92.8 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EWC47644.1 - 0.09 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase zf-CSL PF05207.13 EWC47646.1 - 1.6e-21 75.8 0.1 2e-21 75.5 0.1 1.1 1 0 0 1 1 1 1 CSL zinc finger PPTA PF01239.22 EWC47648.1 - 1.7e-32 110.2 8.8 4.5e-07 29.4 0.0 6.0 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat DUF3950 PF13132.6 EWC47648.1 - 0.025 14.3 0.3 0.068 12.9 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3950) GLTP PF08718.11 EWC47648.1 - 0.063 13.6 1.0 0.6 10.4 0.2 2.7 2 1 0 2 2 2 0 Glycolipid transfer protein (GLTP) Ribosomal_S6e PF01092.19 EWC47649.1 - 6.6e-60 200.6 0.1 6.6e-60 200.6 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S6e Cupin_8 PF13621.6 EWC47650.1 - 2.7e-62 210.8 0.1 4e-62 210.2 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EWC47650.1 - 0.039 14.4 0.0 0.13 12.8 0.0 1.8 1 0 0 1 1 1 0 JmjC domain, hydroxylase HTH_33 PF13592.6 EWC47651.1 - 0.19 11.4 0.9 0.28 10.9 0.1 1.7 2 0 0 2 2 2 0 Winged helix-turn helix Pribosyltran_N PF13793.6 EWC47652.1 - 7.2e-46 154.9 0.2 7.4e-45 151.6 0.1 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EWC47652.1 - 1.1e-39 136.3 2.1 4e-32 111.7 0.8 2.6 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EWC47652.1 - 2.4e-16 59.7 0.6 2.4e-16 59.7 0.6 2.6 3 0 0 3 3 3 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EWC47652.1 - 0.00023 20.7 0.2 0.00045 19.7 0.2 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase IF-2B PF01008.17 EWC47652.1 - 0.0056 15.9 0.4 0.0094 15.2 0.4 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family Methyltransf_23 PF13489.6 EWC47655.1 - 6.1e-18 65.2 0.0 9.6e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC47655.1 - 7.9e-11 42.5 0.0 2.1e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC47655.1 - 2.9e-08 34.3 0.0 2.1e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC47655.1 - 4.9e-08 33.6 0.0 1.4e-07 32.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC47655.1 - 5.2e-08 32.8 0.0 1.1e-06 28.5 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EWC47655.1 - 0.0046 16.5 0.2 0.023 14.1 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Inhibitor_I53 PF11714.8 EWC47655.1 - 0.33 11.2 1.0 0.75 10.0 1.0 1.5 1 0 0 1 1 1 0 Thrombin inhibitor Madanin CRAL_TRIO PF00650.20 EWC47656.1 - 8.4e-11 41.8 0.0 1.2e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EWC47656.1 - 0.00039 20.5 0.0 0.00073 19.7 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF4573 PF15140.6 EWC47656.1 - 0.013 15.3 15.6 0.019 14.8 11.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4573) SPATA3 PF15662.5 EWC47656.1 - 6.3 7.4 9.3 14 6.3 5.5 2.2 1 1 1 2 2 2 0 Spermatogenesis-associated protein 3 family Ribosomal_S8e PF01201.22 EWC47657.1 - 2e-55 186.7 3.0 2.3e-55 186.5 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e Glyco_hydro_63 PF03200.16 EWC47659.1 - 4.5e-10 38.9 2.6 2.3e-08 33.3 1.6 3.6 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain OSCP PF00213.18 EWC47660.1 - 1.5e-44 152.1 1.1 1.8e-44 151.9 1.1 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit RRF PF01765.19 EWC47660.1 - 0.15 12.0 1.8 12 5.8 0.1 2.8 2 1 1 3 3 3 0 Ribosome recycling factor MMR_HSR1 PF01926.23 EWC47661.1 - 6e-05 23.1 0.0 0.076 13.1 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EWC47661.1 - 0.038 13.9 0.1 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase Utp12 PF04003.12 EWC47662.1 - 1.4e-21 76.8 0.3 2.7e-21 75.9 0.3 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family Bromodomain PF00439.25 EWC47663.1 - 7.7e-46 154.1 3.3 2.2e-25 88.5 1.1 2.7 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 EWC47663.1 - 4.2e-19 68.5 0.1 4.2e-19 68.5 0.1 2.6 3 0 0 3 3 3 1 Bromodomain extra-terminal - transcription regulation FlxA PF14282.6 EWC47663.1 - 0.17 11.9 9.8 0.099 12.6 0.9 3.3 3 0 0 3 3 3 0 FlxA-like protein CEP63 PF17045.5 EWC47663.1 - 0.52 10.2 3.8 0.24 11.3 1.2 1.7 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa DUF3381 PF11861.8 EWC47663.1 - 2.2 8.1 9.5 0.28 11.0 4.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) RIBIOP_C PF04950.12 EWC47665.1 - 7e-105 350.6 0.1 1.5e-104 349.6 0.0 1.6 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EWC47665.1 - 9.6e-13 48.0 0.0 2.5e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain BING4CT PF08149.11 EWC47666.1 - 1.2e-37 127.6 0.5 1.8e-36 123.8 0.0 2.9 4 0 0 4 4 4 1 BING4CT (NUC141) domain WD40 PF00400.32 EWC47666.1 - 0.00017 22.3 0.4 1.3 10.0 0.0 4.6 6 1 0 6 6 6 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EWC47666.1 - 0.0015 17.7 0.0 0.0033 16.5 0.0 1.5 1 0 0 1 1 1 1 Coatomer WD associated region eIF2A PF08662.11 EWC47666.1 - 0.035 14.0 0.0 0.35 10.7 0.1 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EWC47666.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain Mcl1_mid PF12341.8 EWC47666.1 - 0.14 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region RNase_PH PF01138.21 EWC47668.1 - 2.5e-05 24.8 0.1 0.00028 21.4 0.1 2.3 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RINGv PF12906.7 EWC47670.1 - 8.7e-12 45.0 4.2 1.4e-11 44.4 4.2 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EWC47670.1 - 0.0087 16.4 6.2 0.013 15.8 6.2 1.3 1 0 0 1 1 1 1 Ring finger domain Phi_1 PF04674.12 EWC47670.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region Proteasome PF00227.26 EWC47671.1 - 8.2e-62 208.1 0.0 1.1e-61 207.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EWC47671.1 - 7.5e-11 41.5 0.1 2.7e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature CAP_N PF01213.19 EWC47672.1 - 3.7 6.9 14.5 1.7 8.0 3.1 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal V-SNARE PF05008.15 EWC47674.1 - 6.8e-23 80.8 2.0 6.8e-23 80.8 2.0 1.9 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EWC47674.1 - 4.8e-20 71.6 2.7 4.8e-20 71.6 2.7 2.7 4 0 0 4 4 3 1 Snare region anchored in the vesicle membrane C-terminus TPR_MalT PF17874.1 EWC47674.1 - 0.019 14.4 2.8 0.045 13.1 1.8 1.8 1 1 1 2 2 2 0 MalT-like TPR region Sec20 PF03908.13 EWC47674.1 - 0.02 14.8 1.0 0.066 13.1 0.2 2.2 2 1 0 2 2 2 0 Sec20 DUF4407 PF14362.6 EWC47674.1 - 0.021 14.2 8.9 0.05 13.0 8.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0449 PF15136.6 EWC47674.1 - 0.022 15.2 2.4 0.076 13.5 0.9 2.5 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DUF4449 PF14613.6 EWC47674.1 - 0.023 14.8 2.6 0.034 14.3 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) Exonuc_VII_L PF02601.15 EWC47674.1 - 0.046 13.3 2.6 0.06 12.9 2.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fusion_gly PF00523.18 EWC47674.1 - 0.047 11.9 3.7 0.21 9.8 0.5 2.3 2 1 0 2 2 2 0 Fusion glycoprotein F0 KASH_CCD PF14662.6 EWC47674.1 - 0.069 13.0 1.3 0.19 11.5 0.8 1.9 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH YlqD PF11068.8 EWC47674.1 - 2 8.8 6.0 2.2 8.7 2.3 2.4 1 1 3 4 4 4 0 YlqD protein LPP PF04728.13 EWC47674.1 - 2.1 8.8 10.0 0.39 11.1 0.5 2.9 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Laminin_I PF06008.14 EWC47674.1 - 4.7 6.8 10.5 15 5.2 10.5 1.8 1 1 0 1 1 1 0 Laminin Domain I Mob1_phocein PF03637.17 EWC47675.1 - 5.2e-68 228.3 0.0 6.3e-68 228.1 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family DUF2011 PF09428.10 EWC47676.1 - 5.5e-12 45.8 0.9 5.4e-11 42.6 0.0 2.7 2 2 0 2 2 2 1 Fungal protein of unknown function (DUF2011) SPX PF03105.19 EWC47677.1 - 3e-37 129.5 4.6 1.8e-24 87.4 0.9 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 EWC47677.1 - 3.4e-23 82.4 43.9 5.1e-23 81.9 43.9 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EWC47677.1 - 2.3e-22 79.6 43.9 2.3e-22 79.6 43.9 2.1 2 1 0 2 2 2 1 Citrate transporter SNF2_N PF00176.23 EWC47678.1 - 2.4e-32 112.0 0.0 2.4e-31 108.7 0.0 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Per1 PF04080.13 EWC47679.1 - 0.17 11.6 4.6 6.6 6.4 0.0 2.3 2 1 0 2 2 2 0 Per1-like family MFS_1 PF07690.16 EWC47680.1 - 7.8e-10 38.2 34.4 6.4e-09 35.2 33.3 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC47680.1 - 0.0012 17.7 12.5 0.0012 17.7 12.5 2.9 2 1 1 3 3 3 1 Sugar (and other) transporter Phage_Coat_Gp8 PF05371.12 EWC47680.1 - 0.035 13.9 1.2 0.075 12.8 1.2 1.5 1 0 0 1 1 1 0 Phage major coat protein, Gp8 Pkinase PF00069.25 EWC47681.1 - 7.6e-58 195.9 0.0 1.1e-57 195.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47681.1 - 1.2e-31 109.9 0.0 1.8e-30 106.1 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EWC47681.1 - 0.0048 15.9 0.0 0.0076 15.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EWC47681.1 - 0.06 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EWC47681.1 - 0.2 10.6 0.0 0.3 10.0 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Stc1 PF12898.7 EWC47682.1 - 7.5e-22 77.7 6.5 2.1e-21 76.3 6.5 1.8 1 0 0 1 1 1 1 Stc1 domain zf-CHY PF05495.12 EWC47682.1 - 3.2 8.3 8.2 18 5.9 5.9 2.7 2 1 0 2 2 2 0 CHY zinc finger BIR PF00653.21 EWC47682.1 - 7.3 7.3 7.4 39 5.0 0.0 3.6 2 1 1 3 3 3 0 Inhibitor of Apoptosis domain CCDC158 PF15921.5 EWC47684.1 - 0.035 12.0 0.0 0.046 11.6 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 UPRTase PF14681.6 EWC47687.1 - 6.7e-39 133.5 0.1 1.3e-38 132.6 0.1 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.6 EWC47687.1 - 6.4e-21 75.2 0.0 2e-20 73.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain HAD PF12710.7 EWC47687.1 - 3.1e-18 66.8 0.0 6.6e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EWC47687.1 - 1.3e-05 25.6 0.0 2.6e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase AAA_18 PF13238.6 EWC47687.1 - 0.00029 21.4 0.0 0.0021 18.6 0.0 2.5 2 1 1 3 3 2 1 AAA domain AAA_16 PF13191.6 EWC47687.1 - 0.0004 20.8 0.0 0.0017 18.8 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EWC47687.1 - 0.001 18.8 0.0 1.6 8.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 EWC47687.1 - 0.004 16.2 0.0 0.0082 15.2 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB KAP_NTPase PF07693.14 EWC47687.1 - 0.0073 15.6 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 KAP family P-loop domain AAA_33 PF13671.6 EWC47687.1 - 0.013 15.6 0.0 0.1 12.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EWC47687.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EWC47687.1 - 0.022 15.0 0.4 0.5 10.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 EWC47687.1 - 0.033 14.3 0.0 0.14 12.2 0.0 2.1 1 0 0 1 1 1 0 Shikimate kinase PRTase_2 PF15609.6 EWC47687.1 - 0.045 13.2 0.2 0.097 12.2 0.2 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase AAA_24 PF13479.6 EWC47687.1 - 0.096 12.4 0.1 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain Peptidase_U4 PF03419.13 EWC47687.1 - 0.1 11.8 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 Sporulation factor SpoIIGA AAA PF00004.29 EWC47687.1 - 0.13 12.7 0.0 0.46 10.9 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EWC47687.1 - 0.14 11.5 0.0 1.9 7.7 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin ATPase_2 PF01637.18 EWC47687.1 - 0.18 11.7 0.5 0.5 10.2 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Pribosyltran PF00156.27 EWC47687.1 - 0.19 11.2 0.4 1.9 8.0 0.2 2.5 2 1 0 2 2 2 0 Phosphoribosyl transferase domain Pkinase_Tyr PF07714.17 EWC47689.1 - 0.0026 17.1 0.0 0.0071 15.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EWC47689.1 - 0.015 14.7 0.0 0.034 13.5 0.0 1.6 1 1 0 1 1 1 0 Protein kinase domain DUF4221 PF13970.6 EWC47689.1 - 0.082 12.5 0.2 0.12 11.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4221) Glyco_hydro_61 PF03443.14 EWC47691.1 - 2e-62 210.8 0.0 2.6e-62 210.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CAP59_mtransfer PF11735.8 EWC47692.1 - 4.7e-60 203.3 0.0 6.3e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Glyco_tranf_2_4 PF13704.6 EWC47692.1 - 0.54 10.8 2.0 0.67 10.5 0.0 2.2 3 0 0 3 3 3 0 Glycosyl transferase family 2 Ank_2 PF12796.7 EWC47693.1 - 7.5e-49 164.3 7.1 1e-12 48.4 0.1 7.0 3 2 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC47693.1 - 6.9e-29 99.9 4.2 2.8e-05 24.6 0.0 10.0 4 3 5 10 10 10 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC47693.1 - 4.8e-28 94.1 12.2 0.0044 17.4 0.0 12.7 14 0 0 14 14 14 6 Ankyrin repeat Ank PF00023.30 EWC47693.1 - 2.9e-27 93.9 24.8 4.4e-05 23.7 0.1 11.9 12 0 0 12 12 12 8 Ankyrin repeat Ank_5 PF13857.6 EWC47693.1 - 2.6e-20 72.2 17.7 0.0013 18.9 0.2 9.8 6 4 6 12 12 11 8 Ankyrin repeats (many copies) DUF676 PF05057.14 EWC47693.1 - 8e-05 22.2 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EWC47693.1 - 0.00029 21.5 0.0 0.00029 21.5 0.0 2.8 3 0 0 3 3 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC47693.1 - 0.00072 18.9 0.0 0.0018 17.6 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EWC47693.1 - 0.0012 18.6 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Cutinase PF01083.22 EWC47693.1 - 0.04 13.9 0.0 0.091 12.7 0.0 1.5 1 0 0 1 1 1 0 Cutinase LCAT PF02450.15 EWC47693.1 - 0.058 12.6 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF829 PF05705.14 EWC47693.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) DUF726 PF05277.12 EWC47693.1 - 0.18 10.7 0.0 0.35 9.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Vps62 PF06101.11 EWC47694.1 - 7.2e-12 44.4 4.7 3.6e-11 42.1 4.7 2.0 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Spherulin4 PF12138.8 EWC47695.1 - 7.5e-41 140.3 1.0 9.8e-41 140.0 1.0 1.1 1 0 0 1 1 1 1 Spherulation-specific family 4 GST_C PF00043.25 EWC47696.1 - 1.3e-07 31.8 0.0 2e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EWC47696.1 - 3.2e-06 27.2 0.0 6.7e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EWC47696.1 - 2.7e-05 24.1 0.0 6e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EWC47696.1 - 0.14 12.6 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain PBD PF00786.28 EWC47697.1 - 0.007 16.7 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain DUF89 PF01937.19 EWC47698.1 - 1.7e-116 389.0 0.0 2e-116 388.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Acyltransferase PF01553.21 EWC47699.1 - 1.1e-24 86.5 0.0 1.8e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EWC47699.1 - 7.2e-12 45.2 0.0 1.6e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus DUF5564 PF17719.1 EWC47700.1 - 0.046 13.9 1.2 0.046 13.9 1.2 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5564) HGTP_anticodon PF03129.20 EWC47702.1 - 3.4e-20 72.0 0.0 9.1e-20 70.6 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EWC47702.1 - 1e-08 35.4 0.1 2.6e-08 34.1 0.1 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) SYF2 PF08231.12 EWC47702.1 - 0.37 11.2 4.6 3.5 8.0 1.2 3.1 3 0 0 3 3 3 0 SYF2 splicing factor Epimerase PF01370.21 EWC47704.1 - 9.8e-18 64.5 0.0 1.6e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EWC47704.1 - 2.4e-10 39.9 0.0 4.4e-10 39.0 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EWC47704.1 - 3.2e-09 36.9 0.0 9.1e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EWC47704.1 - 5e-09 35.7 0.0 7.8e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EWC47704.1 - 2.9e-07 30.3 0.0 2.1e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EWC47704.1 - 4.3e-07 29.7 0.0 8e-06 25.5 0.0 2.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EWC47704.1 - 3.4e-05 23.1 0.0 0.012 14.8 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 EWC47704.1 - 9.9e-05 21.9 0.1 0.0009 18.7 0.0 2.3 2 1 0 2 2 2 1 short chain dehydrogenase MBOAT_2 PF13813.6 EWC47705.1 - 2.4e-09 37.3 6.6 2.4e-09 37.3 6.6 2.0 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family MARVEL PF01284.23 EWC47706.1 - 0.00014 21.9 9.2 0.00021 21.3 9.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain NdhL PF10716.9 EWC47706.1 - 0.038 14.0 0.1 0.086 12.8 0.1 1.6 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit DUF4079 PF13301.6 EWC47706.1 - 1.8 8.7 5.1 16 5.6 0.5 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) Glyco_hydro_6 PF01341.17 EWC47707.1 - 2.9e-101 339.2 0.1 4.3e-101 338.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 CBM_1 PF00734.18 EWC47707.1 - 1.7e-13 50.3 7.2 4.5e-13 48.9 7.2 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain DUF908 PF06012.12 EWC47707.1 - 0.021 14.2 6.5 0.028 13.8 6.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SOG2 PF10428.9 EWC47707.1 - 2.7 7.1 17.9 3.7 6.6 17.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein CheW PF01584.19 EWC47709.1 - 0.13 11.9 2.4 1.3 8.6 0.1 2.6 3 0 0 3 3 3 0 CheW-like domain TPR_2 PF07719.17 EWC47710.1 - 1.1e-27 93.8 33.6 0.0016 18.4 0.0 12.3 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47710.1 - 1.8e-27 94.0 28.0 0.0022 17.7 0.0 10.7 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47710.1 - 5e-24 84.7 16.9 0.00041 20.9 0.8 9.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_6 PF13174.6 EWC47710.1 - 3.8e-16 58.6 18.5 0.066 13.9 0.1 13.3 15 0 0 15 15 13 2 Tetratricopeptide repeat TPR_12 PF13424.6 EWC47710.1 - 9.1e-16 57.9 22.6 3.4e-05 24.0 1.5 8.1 6 2 3 9 9 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47710.1 - 8.5e-14 51.1 18.9 0.0084 16.8 0.2 11.1 9 3 4 13 13 12 3 Tetratricopeptide repeat TPR_11 PF13414.6 EWC47710.1 - 4.2e-12 45.5 24.4 0.00032 20.3 0.0 10.2 10 0 0 10 10 10 3 TPR repeat TPR_8 PF13181.6 EWC47710.1 - 4.3e-12 45.2 38.5 0.19 12.0 0.1 12.0 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_19 PF14559.6 EWC47710.1 - 2.9e-11 43.7 26.0 0.0011 19.4 0.0 10.1 9 2 1 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.6 EWC47710.1 - 4.5e-08 32.6 19.2 0.15 12.1 0.3 8.9 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EWC47710.1 - 4.6e-08 32.9 12.7 1.8 9.1 0.0 9.3 11 0 0 11 11 9 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC47710.1 - 0.00021 21.4 18.9 2.9 8.2 0.7 7.3 8 1 1 9 9 9 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 EWC47710.1 - 0.00031 20.7 3.6 4.2 7.5 0.0 4.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EWC47710.1 - 0.002 18.2 0.6 14 5.9 0.0 5.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EWC47710.1 - 0.042 13.7 26.9 0.079 12.9 0.3 7.7 9 0 0 9 9 9 0 Tetratricopeptide repeat TOM20_plant PF06552.12 EWC47710.1 - 9.6 5.9 9.6 2.8 7.6 0.1 3.9 5 0 0 5 5 5 0 Plant specific mitochondrial import receptor subunit TOM20 SBP56 PF05694.11 EWC47711.1 - 7.6e-06 25.0 0.0 0.0014 17.5 0.0 2.3 2 0 0 2 2 2 2 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 EWC47711.1 - 0.012 14.9 0.1 4.2 6.5 0.0 2.7 2 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Cupin_1 PF00190.22 EWC47712.1 - 2.9e-34 117.8 0.2 3.1e-18 65.8 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EWC47712.1 - 4.6e-20 71.1 2.2 1.7e-12 46.8 0.2 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EWC47712.1 - 3.9e-05 23.3 0.0 0.0012 18.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 EWC47712.1 - 0.079 12.9 0.1 0.51 10.2 0.0 2.2 2 0 0 2 2 2 0 AraC-like ligand binding domain 3-HAO PF06052.12 EWC47712.1 - 0.11 12.2 0.0 1.6 8.3 0.0 2.4 2 1 1 3 3 3 0 3-hydroxyanthranilic acid dioxygenase Cupin_6 PF12852.7 EWC47712.1 - 0.15 11.7 0.1 20 4.8 0.0 2.3 2 0 0 2 2 2 0 Cupin Glyco_hydro_61 PF03443.14 EWC47713.1 - 3.8e-34 118.4 0.0 7.7e-34 117.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EWC47713.1 - 1.2e-12 47.5 28.1 9.8e-08 31.8 14.3 2.9 3 0 0 3 3 3 2 Fungal cellulose binding domain Toxin_7 PF05980.12 EWC47713.1 - 0.88 9.9 2.5 1.8 8.9 2.5 1.5 1 0 0 1 1 1 0 Toxin 7 CBM_1 PF00734.18 EWC47714.1 - 7.4e-23 80.2 38.0 2.3e-10 40.3 6.7 4.3 4 0 0 4 4 4 3 Fungal cellulose binding domain EGF_MSP1_1 PF12946.7 EWC47714.1 - 0.0005 20.1 0.8 1.4 9.1 0.1 2.7 2 0 0 2 2 2 2 MSP1 EGF domain 1 Profilin PF00235.19 EWC47714.1 - 0.029 14.7 0.0 1.9 8.8 0.0 2.2 1 1 1 2 2 2 0 Profilin Lustrin_cystein PF14625.6 EWC47714.1 - 0.051 13.9 13.0 2.3 8.6 3.2 3.0 1 1 1 2 2 2 0 Lustrin, cysteine-rich repeated domain FYRN PF05964.14 EWC47714.1 - 0.081 12.8 3.0 2 8.3 0.2 2.4 2 0 0 2 2 2 0 F/Y-rich N-terminus CC PF04942.14 EWC47714.1 - 0.89 9.8 12.4 2.8 8.2 0.7 3.3 3 0 0 3 3 3 0 CC domain Granulin PF00396.18 EWC47714.1 - 1.5 9.2 6.0 14 6.1 0.6 2.9 2 0 0 2 2 2 0 Granulin SurE PF01975.17 EWC47716.1 - 8.3e-38 130.1 0.0 1.5e-37 129.3 0.0 1.4 1 0 0 1 1 1 1 Survival protein SurE Brix PF04427.18 EWC47717.1 - 1.7e-24 87.0 0.0 6.1e-24 85.2 0.0 1.8 2 0 0 2 2 2 1 Brix domain BUD22 PF09073.10 EWC47717.1 - 0.36 10.1 20.9 0.52 9.6 20.9 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EWC47717.1 - 0.62 8.2 13.1 0.79 7.9 13.1 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EWC47717.1 - 6.7 5.1 6.4 12 4.3 6.4 1.3 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RIX1 PF08167.12 EWC47718.1 - 4e-36 124.5 6.0 4e-36 124.5 6.0 2.2 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis TPR_2 PF07719.17 EWC47719.1 - 0.00091 19.2 3.7 1.5 9.1 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47719.1 - 0.011 16.5 4.7 18 6.5 0.1 5.3 2 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EWC47719.1 - 0.026 15.0 10.9 0.99 10.0 0.1 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47719.1 - 0.045 14.0 1.8 16 6.0 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EWC47719.1 - 0.072 13.5 0.0 1.8e+02 2.9 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47719.1 - 0.086 13.5 0.1 0.086 13.5 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 EWC47719.1 - 0.11 12.8 0.5 7.9 6.9 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47719.1 - 0.15 11.9 0.1 13 5.8 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Kp4 PF09044.10 EWC47720.1 - 5.4e-11 42.7 0.2 2.9e-10 40.3 0.2 1.8 1 1 0 1 1 1 1 Kp4 ABC_tran PF00005.27 EWC47721.1 - 1.9e-47 161.2 0.1 3.7e-23 82.6 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EWC47721.1 - 1.4e-22 79.5 4.0 1.4e-22 79.5 4.0 2.9 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 EWC47721.1 - 1.4e-16 61.2 0.3 0.0022 17.8 0.1 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EWC47721.1 - 8.8e-10 38.4 1.0 0.053 13.0 0.1 4.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EWC47721.1 - 5.4e-08 33.4 0.0 0.0023 18.4 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EWC47721.1 - 1.6e-07 32.1 2.8 0.049 14.1 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EWC47721.1 - 3.3e-07 30.0 0.1 0.012 15.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EWC47721.1 - 6.3e-07 29.4 0.5 0.0018 18.2 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_18 PF13238.6 EWC47721.1 - 7.4e-07 29.8 0.1 0.011 16.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 EWC47721.1 - 3.7e-06 27.0 0.2 0.013 15.5 0.1 3.0 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 EWC47721.1 - 8e-06 25.8 0.0 0.17 11.6 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EWC47721.1 - 1.6e-05 25.2 0.0 0.29 11.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EWC47721.1 - 1.7e-05 25.3 0.6 0.44 11.0 0.0 3.5 3 2 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EWC47721.1 - 2.1e-05 24.5 0.3 0.088 12.7 0.0 2.7 2 0 0 2 2 2 2 NACHT domain NB-ARC PF00931.22 EWC47721.1 - 2.6e-05 23.5 0.0 0.34 10.1 0.0 3.3 2 1 0 2 2 2 2 NB-ARC domain AAA_33 PF13671.6 EWC47721.1 - 9.7e-05 22.6 0.1 0.1 12.8 0.1 2.9 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 EWC47721.1 - 0.00014 22.2 0.0 0.29 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EWC47721.1 - 0.00014 22.2 0.6 0.96 9.9 0.0 3.2 3 0 0 3 3 3 2 RNA helicase AAA_14 PF13173.6 EWC47721.1 - 0.00016 21.7 0.0 0.35 10.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EWC47721.1 - 0.00035 20.6 0.1 0.81 9.7 0.1 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EWC47721.1 - 0.00059 19.6 0.9 0.94 9.2 0.0 3.5 4 0 0 4 4 3 1 AAA domain AAA_30 PF13604.6 EWC47721.1 - 0.00067 19.4 0.9 0.68 9.6 0.1 3.8 3 2 0 3 3 3 1 AAA domain TsaE PF02367.17 EWC47721.1 - 0.00098 19.1 0.2 4.1 7.4 0.0 3.5 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 EWC47721.1 - 0.00098 19.3 0.1 1.5 9.0 0.0 3.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 EWC47721.1 - 0.0028 17.6 0.0 2.5 8.0 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain Dynamin_N PF00350.23 EWC47721.1 - 0.0032 17.6 0.9 11 6.0 0.0 3.9 2 1 1 3 3 3 0 Dynamin family ATPase_2 PF01637.18 EWC47721.1 - 0.0037 17.2 0.2 1.5 8.7 0.0 3.0 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EWC47721.1 - 0.0039 16.7 0.0 0.35 10.4 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_17 PF13207.6 EWC47721.1 - 0.0049 17.3 0.0 0.91 10.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EWC47721.1 - 0.0052 16.0 0.0 2.1 7.5 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 EWC47721.1 - 0.0073 16.2 0.1 0.76 9.7 0.1 2.6 2 0 0 2 2 2 1 NTPase MeaB PF03308.16 EWC47721.1 - 0.0075 15.3 0.3 0.55 9.2 0.0 2.7 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 EWC47721.1 - 0.0095 15.5 0.0 2.3 7.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain DUF87 PF01935.17 EWC47721.1 - 0.014 15.5 1.4 7.8 6.5 0.0 3.5 3 1 1 4 4 4 0 Helicase HerA, central domain AAA_27 PF13514.6 EWC47721.1 - 0.033 13.8 0.0 11 5.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 EWC47721.1 - 0.045 13.3 0.0 3.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF2813 PF11398.8 EWC47721.1 - 0.049 12.9 0.6 11 5.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) MCM PF00493.23 EWC47721.1 - 0.057 12.5 0.0 4.8 6.2 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain IstB_IS21 PF01695.17 EWC47721.1 - 0.061 13.0 0.0 1.2 8.9 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein Ras PF00071.22 EWC47721.1 - 0.061 12.9 0.1 12 5.4 0.0 2.7 3 0 0 3 3 2 0 Ras family G-alpha PF00503.20 EWC47721.1 - 0.082 12.0 0.6 3.9 6.5 0.0 2.8 3 1 0 3 3 3 0 G-protein alpha subunit ATP-synt_ab PF00006.25 EWC47721.1 - 0.088 12.4 0.0 0.33 10.6 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.9 EWC47721.1 - 0.11 12.3 0.6 18 5.0 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DAP3 PF10236.9 EWC47721.1 - 0.11 11.6 1.2 10 5.1 0.1 2.7 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 Git3 PF11710.8 EWC47722.1 - 1.6e-18 67.2 6.8 2.7e-18 66.5 6.8 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.11 EWC47722.1 - 9e-05 21.7 8.5 0.0025 17.0 7.3 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 EWC47722.1 - 0.0062 16.6 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Fungal_trans PF04082.18 EWC47723.1 - 4.3e-15 55.4 0.0 6.9e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC47723.1 - 5.7e-09 35.9 11.9 9.7e-09 35.2 11.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Stn1 PF10451.9 EWC47724.1 - 2.1e-11 43.3 0.0 2.5e-11 43.0 0.0 1.0 1 0 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.25 EWC47724.1 - 9e-05 22.4 0.1 0.005 16.8 0.0 2.1 1 1 1 2 2 2 2 OB-fold nucleic acid binding domain PCuAC PF04314.13 EWC47724.1 - 0.042 13.6 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Copper chaperone PCu(A)C Fungal_trans PF04082.18 EWC47725.1 - 1.4e-15 57.1 0.0 3.4e-15 55.8 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC47725.1 - 2.2e-08 34.1 14.6 3.3e-08 33.5 14.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EWC47726.1 - 0.022 14.9 10.0 0.051 13.7 10.0 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3915 PF13054.6 EWC47726.1 - 3.3 7.7 12.3 1.3 9.0 6.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) 4F5 PF04419.14 EWC47726.1 - 8.4 7.4 9.8 13 6.7 1.3 2.6 2 0 0 2 2 2 0 4F5 protein family Fungal_trans_2 PF11951.8 EWC47729.1 - 1.4e-07 30.7 0.0 3e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_S8 PF00082.22 EWC47730.1 - 8.9e-27 94.1 11.6 1.9e-26 93.0 11.6 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EWC47730.1 - 2.6e-13 50.4 1.5 6.3e-13 49.2 1.5 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 GH131_N PF18271.1 EWC47731.1 - 5.2e-64 216.4 2.4 5.2e-64 216.4 2.4 2.2 2 0 0 2 2 2 1 Glycoside hydrolase 131 catalytic N-terminal domain CBM_1 PF00734.18 EWC47731.1 - 2.5e-12 46.5 12.5 6.3e-12 45.2 12.5 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain SOG2 PF10428.9 EWC47731.1 - 0.075 12.2 18.7 0.11 11.7 18.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein RIFIN PF02009.16 EWC47731.1 - 6.6 6.5 7.2 9.8 6.0 7.2 1.2 1 0 0 1 1 1 0 Rifin PKcGMP_CC PF16808.5 EWC47733.1 - 0.029 14.2 4.0 0.029 14.2 4.0 2.7 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Viral_DNA_bi PF02236.17 EWC47733.1 - 0.083 13.1 0.1 0.24 11.6 0.1 1.8 1 0 0 1 1 1 0 Viral DNA-binding protein, all alpha domain XLF PF09302.11 EWC47733.1 - 0.24 11.6 2.4 1.1 9.4 0.9 2.6 2 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF641 PF04859.12 EWC47733.1 - 2.2 8.6 18.6 0.11 12.9 5.9 3.0 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 EWC47733.1 - 8.5 6.4 20.8 1.8 8.6 10.1 2.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus JIP_LZII PF16471.5 EWC47734.1 - 0.19 11.9 15.5 0.35 11.1 2.3 3.7 1 1 2 3 3 3 0 JNK-interacting protein leucine zipper II HALZ PF02183.18 EWC47734.1 - 0.86 9.9 10.8 1.2 9.4 1.2 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper KxDL PF10241.9 EWC47734.1 - 2.1 8.6 7.5 1.8 8.9 4.4 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein Atg14 PF10186.9 EWC47734.1 - 3.4 6.7 18.0 7.4 5.5 18.0 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Shugoshin_N PF07558.11 EWC47734.1 - 3.6 7.5 11.1 0.26 11.2 0.4 3.5 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region DUF1664 PF07889.12 EWC47734.1 - 4.2 7.4 9.3 18 5.4 0.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cnn_1N PF07989.11 EWC47734.1 - 4.3 7.6 19.5 0.58 10.4 8.8 3.1 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 NACHT PF05729.12 EWC47735.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 NACHT domain DUF1090 PF06476.12 EWC47739.1 - 0.12 12.5 0.3 0.62 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) Sec23_helical PF04815.15 EWC47744.1 - 0.071 12.9 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Sec23/Sec24 helical domain WAPL PF07814.13 EWC47744.1 - 0.1 11.3 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin DCP1 PF06058.13 EWC47745.1 - 8.6e-15 54.7 0.0 1.4e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family F-box-like PF12937.7 EWC47747.1 - 0.0035 17.2 0.2 0.0091 15.9 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC47747.1 - 0.0066 16.3 0.1 0.016 15.1 0.1 1.7 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 EWC47747.1 - 0.051 13.9 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 PRANC domain NAD_kinase PF01513.21 EWC47748.1 - 6.1e-46 156.9 0.0 1.2e-45 156.0 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase RhoGAP PF00620.27 EWC47748.1 - 0.034 14.0 0.0 0.083 12.7 0.0 1.6 1 0 0 1 1 1 0 RhoGAP domain Exo_endo_phos PF03372.23 EWC47748.1 - 0.069 12.7 0.0 0.52 9.8 0.0 2.2 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF1573 PF07610.11 EWC47748.1 - 0.076 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) ASH PF15780.5 EWC47748.1 - 0.2 11.9 0.3 12 6.2 0.1 3.3 2 1 0 3 3 3 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin NAD_binding_4 PF07993.12 EWC47749.1 - 0.014 14.6 0.0 0.1 11.8 0.0 2.0 1 1 0 2 2 2 0 Male sterility protein NAD_binding_10 PF13460.6 EWC47749.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 EWC47749.1 - 0.13 11.7 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EWC47749.1 - 0.14 11.3 0.0 0.31 10.1 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Cyclin_C_2 PF16899.5 EWC47750.1 - 1.3e-21 77.0 0.0 2.4e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin C-terminal domain Cyclin_N PF00134.23 EWC47750.1 - 3.5e-06 26.8 0.0 9.9e-06 25.3 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain WD40 PF00400.32 EWC47751.1 - 7.3e-16 58.3 16.4 4.9e-05 24.0 0.0 6.5 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47751.1 - 1.3e-08 35.0 1.3 0.019 15.3 0.4 4.4 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EWC47751.1 - 0.00096 18.2 0.2 0.96 8.3 0.0 3.2 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EWC47751.1 - 0.0053 15.5 1.2 1.5 7.5 0.1 2.9 2 1 1 3 3 3 2 Nup133 N terminal like eIF2A PF08662.11 EWC47751.1 - 0.02 14.8 0.2 0.72 9.7 0.0 3.3 2 1 3 5 5 5 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EWC47751.1 - 0.024 13.3 0.5 0.1 11.3 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 F-box-like PF12937.7 EWC47752.1 - 6.7e-05 22.7 0.0 0.00016 21.5 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC47752.1 - 8e-05 22.4 0.2 0.0056 16.5 0.1 3.2 3 0 0 3 3 3 1 F-box domain LRR_4 PF12799.7 EWC47752.1 - 0.006 17.0 0.5 7 7.2 0.1 4.0 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) PQ-loop PF04193.14 EWC47753.1 - 6.9e-14 51.4 13.8 3e-07 30.1 1.7 2.9 3 0 0 3 3 3 2 PQ loop repeat Phage_holin_3_6 PF07332.11 EWC47753.1 - 0.024 14.7 3.4 0.024 14.7 3.4 3.1 3 1 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Phage_holin_3_7 PF05449.11 EWC47753.1 - 0.51 10.4 13.7 0.23 11.5 2.8 3.3 3 0 0 3 3 3 0 Putative 3TM holin, Phage_holin_3 Pkinase PF00069.25 EWC47756.1 - 9e-19 67.8 0.0 6.1e-13 48.7 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47756.1 - 4.8e-10 39.1 0.0 1.4e-07 31.1 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Abhydrolase_3 PF07859.13 EWC47758.1 - 1e-34 120.3 0.0 1.7e-34 119.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EWC47758.1 - 0.12 11.2 0.0 1.3 7.8 0.0 2.0 2 0 0 2 2 2 0 Carboxylesterase family DNA_methylase PF00145.17 EWC47759.1 - 1.3e-35 123.3 0.0 7.4e-23 81.4 0.0 2.3 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase Methyltransf_15 PF09445.10 EWC47759.1 - 0.0009 18.9 0.1 0.0018 17.9 0.1 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EWC47759.1 - 0.14 12.9 0.1 1.1 10.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain SNF2_N PF00176.23 EWC47760.1 - 8e-37 126.8 0.1 1.3e-36 126.0 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EWC47760.1 - 1.3e-12 48.0 0.1 3e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47760.1 - 1.1e-07 32.1 0.0 3.4e-07 30.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EWC47760.1 - 6.3e-05 22.8 0.0 0.00019 21.2 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EWC47760.1 - 0.0024 17.6 0.0 0.013 15.2 0.0 2.0 2 0 0 2 2 2 1 SWI2/SNF2 ATPase UQ_con PF00179.26 EWC47763.1 - 1.6e-44 151.0 0.0 2.1e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EWC47763.1 - 0.00095 18.9 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UBA_3 PF09288.10 EWC47763.1 - 0.0013 18.5 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain SnAPC_2_like PF11035.8 EWC47763.1 - 0.0073 16.5 0.8 0.0094 16.1 0.8 1.1 1 0 0 1 1 1 1 Small nuclear RNA activating complex subunit 2, SNAP190 Myb RWD PF05773.22 EWC47763.1 - 0.032 14.5 0.0 0.062 13.6 0.0 1.5 1 0 0 1 1 1 0 RWD domain ABC1 PF03109.16 EWC47764.1 - 9.5e-32 109.7 0.0 1.5e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase_Tyr PF07714.17 EWC47765.1 - 1.1e-08 34.7 0.0 4e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EWC47765.1 - 2.6e-06 27.0 0.0 4.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain AAA PF00004.29 EWC47766.1 - 5.1e-41 140.2 0.0 9.1e-41 139.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC47766.1 - 4.7e-10 39.1 0.3 9.2e-10 38.2 0.3 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EWC47766.1 - 1e-09 38.2 0.1 2.3e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EWC47766.1 - 4e-06 27.0 0.0 1.1e-05 25.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EWC47766.1 - 4.8e-06 26.9 0.2 0.032 14.5 0.1 2.4 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 EWC47766.1 - 1.3e-05 24.5 0.0 2.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EWC47766.1 - 6.3e-05 23.0 0.0 0.00017 21.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EWC47766.1 - 0.00037 20.9 0.4 0.0039 17.6 0.3 2.2 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EWC47766.1 - 0.0005 19.8 0.0 0.00096 18.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EWC47766.1 - 0.0072 15.7 0.2 0.34 10.2 0.1 2.7 2 1 0 3 3 3 1 KaiC AAA_28 PF13521.6 EWC47766.1 - 0.0085 16.4 0.0 0.027 14.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EWC47766.1 - 0.011 15.0 0.4 0.026 13.7 0.0 1.8 2 1 1 3 3 3 0 TIP49 P-loop domain IstB_IS21 PF01695.17 EWC47766.1 - 0.016 14.9 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EWC47766.1 - 0.018 15.2 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EWC47766.1 - 0.021 15.3 0.0 0.036 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EWC47766.1 - 0.024 14.5 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EWC47766.1 - 0.026 14.5 0.1 0.79 9.6 0.1 2.5 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.16 EWC47766.1 - 0.031 13.7 0.6 0.27 10.6 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 EWC47766.1 - 0.037 13.3 0.0 0.088 12.1 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 EWC47766.1 - 0.044 14.2 0.0 0.095 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EWC47766.1 - 0.047 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EWC47766.1 - 0.054 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EWC47766.1 - 0.17 11.4 0.1 0.39 10.2 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 EWC47766.1 - 0.18 11.3 1.1 1.4 8.5 0.3 2.5 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EWC47766.1 - 0.19 11.4 2.2 0.24 11.1 0.3 2.1 2 1 0 2 2 2 0 AAA domain Promethin PF16015.5 EWC47767.1 - 2.1e-22 79.1 20.3 3.8e-22 78.2 18.9 1.8 1 1 1 2 2 2 1 Promethin Metallophos PF00149.28 EWC47769.1 - 7.3e-11 42.9 0.8 1.4e-10 42.1 0.8 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EWC47769.1 - 0.0046 17.2 0.0 0.014 15.6 0.0 1.6 1 1 0 1 1 1 1 5'-nucleotidase, C-terminal domain DUF3638 PF12340.8 EWC47772.1 - 3e-91 304.8 1.6 5e-91 304.0 1.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EWC47772.1 - 1.6e-14 53.0 0.1 3.5e-14 51.9 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) HECW1_helix PF18436.1 EWC47773.1 - 0.011 15.9 0.2 0.028 14.5 0.2 1.7 1 0 0 1 1 1 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 AAA_9 PF12781.7 EWC47773.1 - 0.018 14.1 0.2 0.035 13.3 0.2 1.5 1 0 0 1 1 1 0 ATP-binding dynein motor region DHHC PF01529.20 EWC47773.1 - 0.72 10.0 2.9 5.2 7.2 2.6 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase Aldo_ket_red PF00248.21 EWC47774.1 - 1.6e-54 185.1 0.0 1.9e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Frankia_peptide PF14407.6 EWC47774.1 - 0.022 14.7 0.2 0.11 12.5 0.1 2.0 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Aminotran_1_2 PF00155.21 EWC47775.1 - 1.7e-80 270.9 0.0 2.5e-80 270.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EWC47775.1 - 0.00026 19.6 0.0 0.00044 18.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EWC47775.1 - 0.0006 18.9 1.1 0.0016 17.5 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EWC47775.1 - 0.0017 17.8 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family ECH_1 PF00378.20 EWC47776.1 - 3.7e-36 124.7 0.0 8.4e-36 123.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EWC47776.1 - 8.6e-19 68.2 0.0 1.5e-18 67.4 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Citrate_synt PF00285.21 EWC47777.1 - 2.6e-124 415.0 0.1 3.2e-124 414.6 0.1 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Mid1 PF12929.7 EWC47778.1 - 4.4e-126 421.5 5.7 8.2e-88 295.4 3.0 2.2 1 1 1 2 2 2 2 Stretch-activated Ca2+-permeable channel component F-box-like PF12937.7 EWC47778.1 - 7e-05 22.6 0.3 0.00015 21.6 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EWC47778.1 - 0.039 13.8 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 F-box Fz PF01392.22 EWC47778.1 - 0.052 14.2 5.2 0.28 11.8 1.1 2.7 2 0 0 2 2 2 0 Fz domain CFEM PF05730.11 EWC47779.1 - 5.5e-14 52.0 13.3 1.1e-10 41.5 3.3 2.3 2 0 0 2 2 2 2 CFEM domain Gamma-thionin PF00304.20 EWC47779.1 - 7.4 6.9 12.0 9.6 6.6 1.4 2.5 2 0 0 2 2 2 0 Gamma-thionin family adh_short PF00106.25 EWC47781.1 - 5.2e-28 97.8 0.0 2.2e-20 73.0 0.0 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC47781.1 - 3.3e-16 59.6 0.2 4e-15 56.0 0.2 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC47781.1 - 0.018 15.0 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 KR domain WD40 PF00400.32 EWC47781.1 - 0.15 13.0 0.1 1.9 9.5 0.0 2.7 2 0 0 2 2 2 0 WD domain, G-beta repeat Pkinase PF00069.25 EWC47782.1 - 8.4e-68 228.6 1.4 8.4e-67 225.3 1.4 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47782.1 - 3.1e-51 174.2 0.1 6.5e-51 173.1 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EWC47782.1 - 1.8e-22 79.5 0.0 5.2e-22 78.0 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 EWC47782.1 - 1.4e-07 31.9 0.0 3.3e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EWC47782.1 - 2.5e-06 27.0 0.0 4.8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EWC47782.1 - 6.1e-06 25.3 0.0 6.1e-06 25.3 0.0 2.6 2 1 0 2 2 2 1 Fungal protein kinase PH_11 PF15413.6 EWC47782.1 - 0.00039 20.8 1.5 0.00061 20.2 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain Haspin_kinase PF12330.8 EWC47782.1 - 0.021 13.8 0.1 0.043 12.7 0.1 1.5 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EWC47782.1 - 0.048 13.6 0.1 0.048 13.6 0.1 3.5 3 2 1 4 4 4 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EWC47782.1 - 0.056 12.5 0.1 0.1 11.6 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 CH PF00307.31 EWC47783.1 - 4.8e-45 152.2 0.1 3.2e-22 78.8 0.0 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EWC47783.1 - 4.7e-24 84.3 0.2 5e-23 81.0 0.5 2.5 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EWC47783.1 - 1.4e-09 37.6 0.1 1.3e-05 24.9 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 EWC47783.1 - 0.00099 18.9 1.5 0.005 16.7 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 EWC47783.1 - 0.0012 18.6 0.1 0.0052 16.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EWC47783.1 - 0.0048 16.4 0.2 0.43 10.2 0.1 2.9 2 0 0 2 2 2 1 EF hand Spectrin PF00435.21 EWC47783.1 - 0.0071 16.8 5.6 0.1 13.1 0.2 2.6 2 0 0 2 2 2 1 Spectrin repeat EF-hand_7 PF13499.6 EWC47783.1 - 0.31 11.5 1.7 2.4 8.7 1.7 2.7 1 1 0 1 1 1 0 EF-hand domain pair Cu_amine_oxid PF01179.20 EWC47784.1 - 5.1e-159 529.6 0.0 6.1e-159 529.3 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EWC47784.1 - 9.7e-21 74.1 0.3 4.6e-20 71.9 0.0 2.2 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EWC47784.1 - 7.1e-11 42.2 0.0 1.3e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain RdgC PF04381.12 EWC47784.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Putative exonuclease, RdgC CCDC85 PF10226.9 EWC47786.1 - 0.041 13.6 0.7 0.059 13.1 0.3 1.4 2 0 0 2 2 2 0 CCDC85 family DUF4232 PF14016.6 EWC47787.1 - 0.012 15.7 2.3 0.027 14.6 2.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4232) Paramyxo_ncap PF00973.19 EWC47787.1 - 0.66 8.8 7.8 0.93 8.3 7.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PIEZO PF15917.5 EWC47787.1 - 4.1 6.8 8.0 5.9 6.3 8.0 1.2 1 0 0 1 1 1 0 Piezo bZIP_1 PF00170.21 EWC47788.1 - 1.2e-09 38.1 17.5 2e-09 37.4 17.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EWC47788.1 - 4e-05 23.6 20.6 4e-05 23.6 20.6 2.3 1 1 1 2 2 2 1 Basic region leucine zipper UPF0242 PF06785.11 EWC47788.1 - 0.011 15.8 7.6 0.016 15.3 7.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_Maf PF03131.17 EWC47788.1 - 0.023 15.2 13.4 0.039 14.5 13.4 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor NAM-associated PF14303.6 EWC47788.1 - 0.045 14.5 15.8 0.08 13.7 15.8 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Macoilin PF09726.9 EWC47788.1 - 0.05 12.2 4.4 0.063 11.8 4.4 1.2 1 0 0 1 1 1 0 Macoilin family Mcm10 PF09332.11 EWC47788.1 - 0.17 11.3 11.9 0.25 10.7 11.9 1.1 1 0 0 1 1 1 0 Mcm10 replication factor GAS PF13851.6 EWC47788.1 - 0.56 9.5 15.2 0.93 8.8 14.7 1.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EWC47788.1 - 2.1 8.9 13.3 3.3 8.2 13.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 EWC47788.1 - 2.8 5.7 4.5 3.8 5.3 4.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 EWC47788.1 - 7.6 4.7 12.3 11 4.1 12.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Erf4 PF10256.9 EWC47790.1 - 7.1e-35 119.6 0.1 2.6e-33 114.6 0.1 2.1 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family SPX PF03105.19 EWC47790.1 - 0.0083 16.1 2.6 0.014 15.3 2.6 1.3 1 0 0 1 1 1 1 SPX domain TPR_2 PF07719.17 EWC47791.1 - 4.8e-06 26.3 4.1 0.0056 16.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47791.1 - 1.8e-05 24.3 1.2 0.00062 19.5 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC47791.1 - 5.9e-05 23.5 3.7 0.0013 19.1 0.0 3.6 3 2 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EWC47791.1 - 0.0024 18.2 0.0 0.009 16.3 0.0 2.0 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47791.1 - 0.011 15.9 0.3 0.051 13.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EWC47791.1 - 0.012 16.2 0.1 0.065 13.9 0.1 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47791.1 - 0.015 16.0 2.4 1.5 9.5 0.0 3.2 3 1 0 3 3 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 EWC47791.1 - 0.016 15.3 4.9 0.026 14.6 2.0 2.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_9 PF13371.6 EWC47791.1 - 0.037 14.2 1.7 0.1 12.7 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47791.1 - 0.8 10.7 4.9 0.84 10.6 0.1 3.4 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EWC47791.1 - 0.87 9.9 4.4 3.1 8.2 0.1 3.4 3 2 0 3 3 3 0 Tetratricopeptide repeat RNA_pol_I_A49 PF06870.12 EWC47792.1 - 1.8e-74 250.9 0.1 2.3e-74 250.6 0.1 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor CAF1 PF04857.20 EWC47793.1 - 4.3e-20 72.1 0.4 6.6e-11 41.9 0.0 3.3 2 2 1 3 3 3 2 CAF1 family ribonuclease MDM10 PF12519.8 EWC47793.1 - 2.3 7.0 5.4 3.3 6.5 5.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Ilar_coat PF01787.16 EWC47793.1 - 4.3 7.1 10.0 0.073 12.9 3.1 1.5 2 0 0 2 2 2 0 Ilarvirus coat protein DUF4203 PF13886.6 EWC47794.1 - 3.7e-49 167.1 26.8 5e-49 166.7 26.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) BaxI_1 PF12811.7 EWC47794.1 - 0.015 14.9 1.2 0.024 14.2 1.2 1.2 1 0 0 1 1 1 0 Bax inhibitor 1 like Spt20 PF12090.8 EWC47794.1 - 0.13 11.9 8.3 0.34 10.5 8.3 1.6 1 0 0 1 1 1 0 Spt20 family Miga PF10265.9 EWC47794.1 - 8.5 5.2 8.7 15 4.4 0.0 2.4 2 0 0 2 2 2 0 Mitoguardin DDHD PF02862.17 EWC47794.1 - 9 6.4 8.5 1.2 9.3 0.6 3.0 3 0 0 3 3 3 0 DDHD domain Glyco_transf_22 PF03901.17 EWC47795.1 - 1.1e-62 212.7 21.6 1.3e-62 212.4 21.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF2301 PF10063.9 EWC47795.1 - 0.031 14.7 0.5 0.12 12.8 0.5 2.0 1 0 0 1 1 1 0 Uncharacterized integral membrane protein (DUF2301) CYSTM PF12734.7 EWC47797.1 - 3.6e-06 27.2 27.8 3.6e-06 27.2 27.8 4.4 1 1 2 3 3 3 1 Cysteine-rich TM module stress tolerance MUG113 PF13455.6 EWC47798.1 - 6.2e-22 78.1 1.5 2.8e-21 76.0 0.6 2.4 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EWC47798.1 - 6.9e-20 71.5 1.8 2.9e-19 69.5 1.8 2.1 1 1 0 1 1 1 1 T5orf172 domain Skp1 PF01466.19 EWC47799.1 - 8.5e-29 99.4 0.2 1.7e-28 98.5 0.2 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EWC47799.1 - 2.7e-24 85.1 0.1 7.5e-24 83.7 0.1 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain eIF-6 PF01912.18 EWC47801.1 - 6.8e-80 267.1 0.7 8.8e-80 266.7 0.7 1.1 1 0 0 1 1 1 1 eIF-6 family Hydrolase PF00702.26 EWC47803.1 - 0.0023 18.3 0.0 0.0024 18.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EWC47803.1 - 0.027 14.6 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pkinase PF00069.25 EWC47804.1 - 6.7e-53 179.7 0.0 9.8e-53 179.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC47804.1 - 1.3e-30 106.6 0.0 2e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC47804.1 - 3.2e-11 43.1 0.0 2.5e-09 36.9 0.0 2.8 2 1 1 3 3 3 1 Kinase-like Kdo PF06293.14 EWC47804.1 - 0.00051 19.5 0.0 0.00082 18.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Mpp10 PF04006.12 EWC47805.1 - 0.12 10.8 20.0 0.1 11.0 5.7 2.0 2 0 0 2 2 2 0 Mpp10 protein AT_hook PF02178.19 EWC47805.1 - 0.29 11.1 15.6 2.6 8.2 4.5 3.0 2 0 0 2 2 2 0 AT hook motif Nop14 PF04147.12 EWC47805.1 - 0.73 8.0 20.9 0.094 10.9 9.1 2.1 2 0 0 2 2 2 0 Nop14-like family Cwf_Cwc_15 PF04889.12 EWC47805.1 - 1.1 9.0 22.7 0.81 9.4 7.9 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Vfa1 PF08432.10 EWC47805.1 - 4.6 7.5 14.1 3.8 7.8 5.6 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Spore_coat_CotO PF14153.6 EWC47805.1 - 8.6 6.2 18.2 0.4 10.6 5.5 2.2 2 0 0 2 2 2 0 Spore coat protein CotO RNA_pol_3_Rpc31 PF11705.8 EWC47805.1 - 9.6 6.4 25.4 8.6 6.5 4.5 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Vpu PF00558.19 EWC47806.1 - 0.096 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Vpu protein Phostensin_N PF13916.6 EWC47806.1 - 0.19 12.1 3.0 0.55 10.6 3.0 1.8 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal UBA PF00627.31 EWC47807.1 - 7e-27 92.9 6.8 6.6e-13 48.3 0.1 2.7 3 0 0 3 3 3 2 UBA/TS-N domain XPC-binding PF09280.11 EWC47807.1 - 1.5e-25 88.7 9.1 2.7e-25 87.8 9.1 1.5 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 EWC47807.1 - 1.9e-17 62.7 0.0 3.1e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EWC47807.1 - 3.6e-05 23.5 0.0 8.3e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EWC47807.1 - 0.00087 19.4 0.0 0.0023 18.0 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EWC47807.1 - 0.0054 16.5 0.0 0.26 11.1 0.0 2.3 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain DUF2407 PF10302.9 EWC47807.1 - 0.028 15.0 0.0 0.06 13.9 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.6 EWC47807.1 - 0.09 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EWC47807.1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain STI1 PF17830.1 EWC47807.1 - 1.3 9.0 4.4 7 6.7 1.5 3.0 2 1 0 2 2 2 0 STI1 domain Myb_DNA-bind_6 PF13921.6 EWC47808.1 - 0.00023 21.3 0.1 0.00045 20.4 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EWC47808.1 - 0.011 16.0 0.1 0.019 15.1 0.1 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Mg_trans_NIPA PF05653.14 EWC47809.1 - 1.9e-56 191.4 8.7 1.9e-52 178.2 3.4 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EWC47809.1 - 0.00061 20.0 0.6 0.00061 20.0 0.6 4.0 3 1 2 5 5 5 1 EamA-like transporter family SSB PF00436.25 EWC47810.1 - 2.7e-20 72.4 0.2 3.4e-20 72.0 0.2 1.1 1 0 0 1 1 1 1 Single-strand binding protein family CD34_antigen PF06365.12 EWC47812.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family TMIE PF16038.5 EWC47812.1 - 0.23 11.3 0.2 0.3 11.0 0.2 1.1 1 0 0 1 1 1 0 TMIE protein GPI-anchored PF10342.9 EWC47813.1 - 1.3e-20 73.9 1.5 1.3e-20 73.9 1.5 2.3 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family RAP1 PF07218.11 EWC47813.1 - 2.7 6.2 8.5 3.1 5.9 8.5 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) STE3 PF02076.15 EWC47814.1 - 4.7e-56 190.1 20.2 6.1e-56 189.8 20.2 1.1 1 0 0 1 1 1 1 Pheromone A receptor HTH_31 PF13560.6 EWC47814.1 - 0.024 15.0 0.4 14 6.1 0.1 2.9 2 0 0 2 2 2 0 Helix-turn-helix domain DUF5423 PF17461.2 EWC47814.1 - 4.5 6.0 6.7 0.22 10.3 0.5 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5423) Spt4 PF06093.13 EWC47815.1 - 2.4e-27 94.9 0.2 3.1e-27 94.5 0.2 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger ABC_membrane PF00664.23 EWC47816.1 - 1.9e-86 290.1 25.2 1.2e-48 166.2 6.0 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EWC47816.1 - 2.5e-50 170.5 1.0 6e-29 101.3 0.0 3.2 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 EWC47816.1 - 1.9e-09 37.3 5.1 0.00057 19.4 0.2 4.2 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EWC47816.1 - 6.6e-06 26.2 1.0 0.13 12.3 0.1 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EWC47816.1 - 4.1e-05 23.6 0.1 0.033 14.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EWC47816.1 - 0.00011 22.6 0.4 0.19 12.1 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EWC47816.1 - 0.00029 20.5 0.3 0.78 9.5 0.0 3.0 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EWC47816.1 - 0.0042 17.6 4.4 0.067 13.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EWC47816.1 - 0.0076 16.0 0.1 0.23 11.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 EWC47816.1 - 0.0093 16.0 1.1 0.53 10.3 0.1 2.5 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.6 EWC47816.1 - 0.026 14.2 2.0 1.2 8.8 0.0 3.0 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 EWC47816.1 - 0.029 14.6 0.4 5.8 7.2 0.0 3.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EWC47816.1 - 0.046 13.8 3.0 1.4 9.0 0.1 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain NACHT PF05729.12 EWC47816.1 - 0.058 13.3 2.1 0.16 11.9 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_21 PF13304.6 EWC47816.1 - 0.074 12.9 0.7 7.1 6.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RNA_helicase PF00910.22 EWC47816.1 - 0.14 12.6 0.0 15 6.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 EWC47816.1 - 0.15 11.8 0.5 8.4 6.1 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_22 PF13401.6 EWC47816.1 - 0.38 11.0 1.4 32 4.8 0.1 2.8 2 1 0 2 2 2 0 AAA domain DUF2841 PF11001.8 EWC47817.1 - 6.3e-37 126.4 0.2 1.1e-36 125.5 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) US30 PF17624.2 EWC47818.1 - 0.15 11.1 0.5 0.17 10.9 0.5 1.1 1 0 0 1 1 1 0 Family of unknown function CN_hydrolase PF00795.22 EWC47819.1 - 1.2e-09 37.9 0.0 1.2e-07 31.3 0.0 3.0 2 1 0 2 2 2 1 Carbon-nitrogen hydrolase SDA1 PF05285.12 EWC47819.1 - 0.0035 16.8 22.7 0.0054 16.2 22.7 1.3 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 EWC47819.1 - 0.097 10.9 24.6 0.13 10.4 24.6 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 EWC47819.1 - 0.93 8.2 5.7 1.2 7.8 5.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Mpp10 PF04006.12 EWC47819.1 - 0.97 7.8 21.2 1.6 7.1 21.2 1.3 1 0 0 1 1 1 0 Mpp10 protein CDC45 PF02724.14 EWC47819.1 - 9.4 4.4 21.8 16 3.6 21.8 1.3 1 0 0 1 1 1 0 CDC45-like protein UBA_4 PF14555.6 EWC47820.1 - 0.00018 21.3 0.0 0.0004 20.1 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBA PF00627.31 EWC47820.1 - 0.00072 19.4 0.1 0.0014 18.5 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain SlyX PF04102.12 EWC47820.1 - 0.011 16.3 2.5 0.044 14.4 0.4 2.5 2 0 0 2 2 2 0 SlyX CUE PF02845.16 EWC47820.1 - 0.04 13.6 0.0 0.088 12.5 0.0 1.6 1 0 0 1 1 1 0 CUE domain DUF4407 PF14362.6 EWC47820.1 - 0.12 11.6 0.2 0.34 10.2 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 EWC47820.1 - 0.2 11.9 1.0 1.9 8.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) UIM PF02809.20 EWC47820.1 - 1.7 8.7 6.4 0.12 12.3 1.0 2.0 2 0 0 2 2 2 0 Ubiquitin interaction motif HLH PF00010.26 EWC47821.1 - 6.1e-13 48.5 0.9 1.2e-12 47.6 0.9 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain GIT1_C PF12205.8 EWC47821.1 - 0.0064 16.6 0.8 0.019 15.1 0.8 1.7 1 1 0 1 1 1 1 G protein-coupled receptor kinase-interacting protein 1 C term DUF1759 PF03564.15 EWC47821.1 - 0.074 13.0 0.3 0.12 12.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) SPX PF03105.19 EWC47821.1 - 8.4 6.2 20.3 21 4.9 20.3 1.6 1 1 0 1 1 1 0 SPX domain F-box-like PF12937.7 EWC47822.1 - 7e-05 22.6 0.0 0.00016 21.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC47822.1 - 8.4e-05 22.3 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EWC47822.1 - 0.05 13.5 0.0 0.09 12.7 0.0 1.6 1 1 0 1 1 1 0 F-box DUF1770 PF08589.10 EWC47823.1 - 1.9e-22 80.1 0.2 2.4e-22 79.8 0.2 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) His_biosynth PF00977.21 EWC47824.1 - 9e-33 113.6 0.0 1.3e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein TPIP1 PF15338.6 EWC47824.1 - 0.026 14.6 0.0 0.065 13.3 0.0 1.7 1 0 0 1 1 1 0 p53-regulated apoptosis-inducing protein 1 End_beta_propel PF12217.8 EWC47824.1 - 0.089 11.5 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Catalytic beta propeller domain of bacteriophage endosialidase Aminotran_3 PF00202.21 EWC47825.1 - 3e-117 391.7 0.0 3.5e-117 391.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Rit1_C PF17184.4 EWC47826.1 - 4.3e-86 288.7 0.0 1.6e-73 247.5 0.0 2.1 1 1 1 2 2 2 2 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EWC47826.1 - 1.3e-31 109.1 0.0 2.8e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain STE PF02200.16 EWC47827.1 - 5.2e-56 187.8 0.1 8.7e-56 187.1 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EWC47827.1 - 1.7e-08 34.4 27.4 4.9e-06 26.7 3.7 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC47827.1 - 1.7e-07 31.3 14.9 3.3e-07 30.4 4.5 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC47827.1 - 3.7e-06 27.3 17.7 0.0023 18.6 2.0 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EWC47827.1 - 8.3e-05 22.8 2.3 0.0066 16.7 0.7 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EWC47827.1 - 0.0003 20.7 2.3 0.0003 20.7 2.3 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EWC47827.1 - 0.18 12.1 3.2 0.23 11.8 1.2 2.1 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-BED PF02892.15 EWC47827.1 - 0.23 11.5 4.3 0.66 10.0 4.1 1.8 1 1 1 2 2 2 0 BED zinc finger DUF5527 PF17665.1 EWC47827.1 - 0.64 9.5 2.8 1.5 8.4 2.8 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5527) zf-C2HE PF16278.5 EWC47827.1 - 3.1 8.3 5.4 2.4 8.7 0.4 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-MYST PF17772.1 EWC47827.1 - 4.3 7.0 5.5 31 4.3 5.5 2.2 1 1 0 1 1 1 0 MYST family zinc finger domain SOR_SNZ PF01680.17 EWC47828.1 - 7.8e-108 359.0 2.5 1.2e-107 358.4 2.5 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EWC47828.1 - 5.4e-09 35.7 5.6 2e-07 30.6 0.2 2.4 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG NanE PF04131.14 EWC47828.1 - 0.00012 21.3 0.6 0.039 13.1 0.0 3.2 3 0 0 3 3 3 1 Putative N-acetylmannosamine-6-phosphate epimerase TetR_C_27 PF17935.1 EWC47828.1 - 0.00015 21.8 0.0 0.00034 20.6 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Dus PF01207.17 EWC47828.1 - 0.0039 16.3 1.3 0.48 9.5 0.0 2.6 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.21 EWC47828.1 - 0.007 15.6 0.0 0.64 9.1 0.0 2.5 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase FMN_dh PF01070.18 EWC47828.1 - 0.024 13.7 0.1 0.6 9.1 0.0 2.4 2 1 0 2 2 2 0 FMN-dependent dehydrogenase His_biosynth PF00977.21 EWC47828.1 - 0.033 13.7 0.6 0.17 11.3 0.1 2.4 3 0 0 3 3 3 0 Histidine biosynthesis protein TMP-TENI PF02581.17 EWC47828.1 - 0.091 12.1 0.5 2.7 7.3 0.0 2.9 3 0 0 3 3 3 0 Thiamine monophosphate synthase NMO PF03060.15 EWC47828.1 - 0.18 11.1 6.8 0.21 10.9 0.3 2.4 2 1 0 2 2 2 0 Nitronate monooxygenase Spo12 PF05032.12 EWC47829.1 - 9.4e-15 54.2 4.1 1.8e-14 53.3 4.1 1.6 1 0 0 1 1 1 1 Spo12 family DUF3729 PF12526.8 EWC47829.1 - 1.2 10.7 6.1 1 11.0 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3729) SET PF00856.28 EWC47830.1 - 3.9e-15 56.7 0.1 3.9e-15 56.7 0.1 4.1 3 2 0 3 3 3 1 SET domain WW PF00397.26 EWC47830.1 - 7.2e-12 45.2 3.8 1.7e-11 44.0 3.8 1.7 1 0 0 1 1 1 1 WW domain AWS PF17907.1 EWC47830.1 - 7e-10 38.8 6.6 7e-10 38.8 6.6 2.9 3 0 0 3 3 3 1 AWS domain Med26 PF08711.11 EWC47830.1 - 3.7e-05 23.7 1.6 8.3e-05 22.5 0.5 2.3 2 0 0 2 2 2 1 TFIIS helical bundle-like domain SRI PF08236.11 EWC47830.1 - 6.2e-05 23.1 4.1 6.2e-05 23.1 4.1 2.4 2 1 1 3 3 3 1 SRI (Set2 Rpb1 interacting) domain Amino_oxidase PF01593.24 EWC47831.1 - 0.031 13.6 0.1 0.04 13.2 0.1 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase MFS_2 PF13347.6 EWC47832.1 - 1.7e-08 33.5 7.5 2e-08 33.3 0.8 3.2 3 1 0 3 3 3 2 MFS/sugar transport protein PUCC PF03209.15 EWC47832.1 - 0.0076 15.3 0.4 0.0076 15.3 0.4 1.8 2 0 0 2 2 2 1 PUCC protein Na_H_Exchanger PF00999.21 EWC47833.1 - 1.9e-69 234.3 38.4 2.5e-69 233.9 38.4 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Atrophin-1 PF03154.15 EWC47833.1 - 2 6.6 6.1 3 6.0 6.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF4602 PF15375.6 EWC47834.1 - 9.3e-16 58.4 18.2 1.1e-13 51.7 18.2 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) DUF4746 PF15928.5 EWC47834.1 - 0.063 12.7 1.4 0.12 11.8 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) eIF-3c_N PF05470.12 EWC47834.1 - 0.076 11.3 3.5 0.084 11.2 3.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Apt1 PF10351.9 EWC47834.1 - 0.34 9.7 13.3 0.42 9.4 13.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain NOA36 PF06524.12 EWC47834.1 - 0.93 8.7 19.6 0.36 10.1 16.6 1.8 2 0 0 2 2 2 0 NOA36 protein Lin-8 PF03353.15 EWC47834.1 - 2.7 7.5 9.3 4.4 6.8 9.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TRAP_alpha PF03896.16 EWC47834.1 - 5.4 6.1 7.6 9.9 5.3 7.6 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Acyl-CoA_dh_1 PF00441.24 EWC47835.1 - 6e-33 114.2 0.1 1.1e-32 113.3 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EWC47835.1 - 6.4e-17 61.5 0.0 1.1e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EWC47835.1 - 4.8e-14 53.0 0.0 8.7e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EWC47835.1 - 8.9e-13 48.7 0.2 1.8e-12 47.7 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain IF2_N PF04760.15 EWC47836.1 - 0.053 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region MarR_2 PF12802.7 EWC47836.1 - 0.085 12.8 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 MarR family LTV PF04180.14 EWC47837.1 - 1.3e-104 351.0 18.0 1.5e-104 350.8 18.0 1.0 1 0 0 1 1 1 1 Low temperature viability protein Peptidase_C14 PF00656.22 EWC47838.1 - 2.8e-15 57.0 0.0 4.6e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Caspase domain Peptidase_C13 PF01650.18 EWC47838.1 - 0.14 11.7 0.5 2.6 7.5 0.1 2.5 2 1 0 2 2 2 0 Peptidase C13 family DUF4360 PF14273.6 EWC47839.1 - 1.9e-47 161.5 0.1 2.1e-47 161.3 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) DUF3419 PF11899.8 EWC47840.1 - 4.3e-143 477.1 0.0 5.6e-143 476.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EWC47840.1 - 5.8e-11 42.5 0.0 1.6e-09 37.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC47840.1 - 1.2e-09 38.8 0.0 2.3e-07 31.5 0.0 3.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC47840.1 - 4.7e-09 36.8 0.0 0.012 16.3 0.0 4.0 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_31 PF13847.6 EWC47840.1 - 5.4e-09 36.0 0.0 2.5e-06 27.4 0.0 2.8 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EWC47840.1 - 5e-08 33.6 0.0 0.00064 20.4 0.0 3.8 4 0 0 4 4 4 2 Methyltransferase domain Ubie_methyltran PF01209.18 EWC47840.1 - 9.9e-06 25.0 0.0 0.092 12.1 0.0 3.2 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EWC47840.1 - 0.024 14.5 0.0 0.43 10.4 0.0 2.6 3 0 0 3 3 3 0 Hypothetical methyltransferase PCMT PF01135.19 EWC47840.1 - 0.035 13.8 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NmrA PF05368.13 EWC47841.1 - 3.4e-27 95.5 0.1 4.8e-27 95.0 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EWC47841.1 - 3.3e-15 56.4 0.3 1.5e-14 54.3 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EWC47841.1 - 0.00079 19.0 0.0 0.0015 18.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EWC47841.1 - 0.0043 17.5 0.2 0.01 16.3 0.2 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EWC47841.1 - 0.0052 16.9 0.0 0.032 14.3 0.0 2.3 2 1 1 3 3 3 1 Dihydrodipicolinate reductase, N-terminus DUF3646 PF12362.8 EWC47841.1 - 0.034 14.4 0.0 0.071 13.4 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal MFS_1 PF07690.16 EWC47842.1 - 7.1e-24 84.4 37.0 3.5e-18 65.7 11.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EWC47842.1 - 2.9e-07 29.7 0.5 2.9e-07 29.7 0.5 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter DUF2463 PF09591.10 EWC47842.1 - 0.0014 18.6 1.8 0.056 13.3 1.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2463) MFS_1_like PF12832.7 EWC47842.1 - 0.025 13.5 0.1 0.025 13.5 0.1 2.3 2 0 0 2 2 2 0 MFS_1 like family MFS_3 PF05977.13 EWC47842.1 - 0.2 10.0 0.1 0.2 10.0 0.1 3.0 3 0 0 3 3 3 0 Transmembrane secretion effector DUF2909 PF11137.8 EWC47842.1 - 0.29 11.1 2.9 5.3 7.0 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2909) Adeno_E3_CR2 PF02439.15 EWC47843.1 - 0.11 12.3 0.7 0.18 11.6 0.7 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF3431 PF11913.8 EWC47844.1 - 2.9e-05 24.0 0.0 3.7e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DUF3656 PF12392.8 EWC47844.1 - 0.14 12.8 0.0 1 10.0 0.0 2.0 2 0 0 2 2 2 0 Collagenase DUF2236 PF09995.9 EWC47845.1 - 3.8e-06 27.3 0.0 5.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) ZapD PF07072.11 EWC47845.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Cell division protein DAO PF01266.24 EWC47846.1 - 2.6e-53 181.8 0.5 3e-53 181.6 0.5 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EWC47846.1 - 6.4e-09 35.4 0.9 0.0021 17.3 0.0 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EWC47846.1 - 6.1e-05 23.2 0.5 0.00013 22.1 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EWC47846.1 - 0.00015 20.9 1.8 0.03 13.4 0.1 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein GIDA PF01134.22 EWC47846.1 - 0.00069 18.8 2.5 0.0081 15.3 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EWC47846.1 - 0.00092 18.5 2.5 0.0052 16.1 0.4 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EWC47846.1 - 0.0012 19.3 0.2 0.0032 18.0 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EWC47846.1 - 0.005 16.0 2.7 0.014 14.5 0.6 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 EWC47846.1 - 0.0052 16.8 0.1 0.79 9.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GMC_oxred_N PF00732.19 EWC47846.1 - 0.017 14.5 0.6 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase Trp_halogenase PF04820.14 EWC47846.1 - 0.1 11.4 1.2 0.16 10.8 1.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EWC47846.1 - 0.13 11.5 0.6 5.8 6.1 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EWC47846.1 - 0.27 10.4 1.8 0.3 10.3 0.8 1.5 2 0 0 2 2 2 0 FAD binding domain MFS_1 PF07690.16 EWC47848.1 - 1.6e-07 30.6 19.4 1.9e-06 27.0 16.2 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 EWC47848.1 - 6.8e-06 25.0 0.0 1.2e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 Vacuole effluxer Atg22 like DUF3704 PF12488.8 EWC47848.1 - 0.36 10.5 3.0 1.3 8.8 2.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) Pex14_N PF04695.13 EWC47848.1 - 2.5 8.7 9.5 0.77 10.4 4.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ORC6 PF05460.13 EWC47848.1 - 6.9 5.8 12.4 0.75 9.0 7.5 1.7 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) zf-C2H2 PF00096.26 EWC47850.1 - 0.0026 18.1 14.9 2.9 8.5 0.1 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-met PF12874.7 EWC47850.1 - 0.056 13.9 4.4 3.2 8.3 0.7 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type TF_Zn_Ribbon PF08271.12 EWC47850.1 - 0.093 12.3 0.9 14 5.3 0.0 2.8 2 0 0 2 2 2 0 TFIIB zinc-binding zf-C2H2_jaz PF12171.8 EWC47850.1 - 0.2 12.0 7.5 3.5 8.0 0.7 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EWC47850.1 - 0.79 10.7 17.1 8.6 7.5 0.1 4.9 4 1 0 4 4 4 0 C2H2-type zinc finger Cnn_1N PF07989.11 EWC47851.1 - 0.052 13.7 2.3 0.15 12.3 2.3 1.7 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Secretin_N_2 PF07655.13 EWC47851.1 - 6.1 7.5 7.9 17 6.0 3.0 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain EPL1 PF10513.9 EWC47852.1 - 1e-21 78.0 1.0 2.2e-21 76.9 1.0 1.7 1 1 0 1 1 1 1 Enhancer of polycomb-like PHD PF00628.29 EWC47852.1 - 0.00037 20.3 3.6 0.00071 19.4 3.6 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EWC47852.1 - 0.0012 18.3 0.2 0.0012 18.3 0.2 1.7 2 0 0 2 2 2 1 PHD-finger zf-RRPl_C4 PF17026.5 EWC47852.1 - 0.19 11.8 1.7 0.32 11.1 1.7 1.3 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-HC5HC2H PF13771.6 EWC47853.1 - 4.3e-27 94.2 1.8 8.5e-27 93.3 1.8 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EWC47853.1 - 1.8e-26 92.4 1.7 3.4e-26 91.6 1.7 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain Bromodomain PF00439.25 EWC47853.1 - 0.011 15.8 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Bromodomain zf-RING-like PF08746.11 EWC47853.1 - 0.02 15.2 7.2 0.036 14.4 7.2 1.4 1 0 0 1 1 1 0 RING-like domain zf-C2H2 PF00096.26 EWC47854.1 - 7.5e-07 29.3 11.0 0.051 14.1 0.1 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC47854.1 - 0.00017 22.1 9.3 0.068 14.0 1.5 4.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EWC47854.1 - 0.0028 18.0 9.5 1.4 9.5 0.5 4.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-Di19 PF05605.12 EWC47854.1 - 0.51 10.7 9.7 0.63 10.4 1.0 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Haspin_kinase PF12330.8 EWC47856.1 - 0.53 9.2 3.1 0.82 8.5 3.1 1.4 1 1 0 1 1 1 0 Haspin like kinase domain F_actin_bind PF08919.10 EWC47857.1 - 0.063 13.4 5.2 0.046 13.8 2.4 2.2 2 0 0 2 2 2 0 F-actin binding CMD PF02627.20 EWC47857.1 - 0.066 13.3 0.8 0.22 11.6 0.1 2.3 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Hemocyanin_C PF03723.14 EWC47857.1 - 0.29 10.4 1.7 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Hemocyanin, ig-like domain DUF4407 PF14362.6 EWC47857.1 - 1.5 8.1 11.1 4.3 6.6 3.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Csm2_III-A PF03750.13 EWC47857.1 - 2.2 9.2 10.6 0.49 11.2 1.1 3.1 3 0 0 3 3 3 0 Csm2 Type III-A DUF948 PF06103.11 EWC47857.1 - 2.8 8.3 12.1 0.72 10.1 1.6 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) YkyA PF10368.9 EWC47857.1 - 2.8 7.6 18.7 4.9 6.8 4.2 2.4 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein KELK PF15796.5 EWC47857.1 - 3.6 8.1 13.1 0.48 10.9 3.8 2.8 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Sec8_exocyst PF04048.14 EWC47857.1 - 5.9 6.8 13.7 0.31 10.9 3.6 3.2 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain AAA_23 PF13476.6 EWC47857.1 - 5.9 7.3 6.9 1.3 9.5 0.8 2.2 2 0 0 2 2 2 0 AAA domain zf-RING_2 PF13639.6 EWC47858.1 - 1.9e-07 31.3 2.3 1.9e-07 31.3 2.3 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EWC47858.1 - 5.3e-07 29.8 7.0 2.1e-06 27.9 7.0 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EWC47858.1 - 3e-06 27.0 0.6 7.5e-06 25.7 0.6 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EWC47858.1 - 5.7e-05 22.9 3.8 0.00018 21.3 3.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC47858.1 - 6.7e-05 22.8 2.2 0.00029 20.7 0.5 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EWC47858.1 - 7.9e-05 22.6 0.2 0.00024 21.1 0.2 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EWC47858.1 - 0.00014 21.7 6.9 0.00026 20.8 2.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EWC47858.1 - 0.00027 20.5 0.7 0.00062 19.3 0.7 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EWC47858.1 - 0.00084 19.1 1.5 0.0027 17.5 1.5 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EWC47858.1 - 0.0022 17.8 0.6 0.0022 17.8 0.6 1.8 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EWC47858.1 - 0.083 13.1 1.0 0.18 12.0 1.0 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EWC47858.1 - 0.36 10.9 5.8 3.5 7.8 5.8 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RRM_1 PF00076.22 EWC47859.1 - 4.3e-20 71.3 0.0 6.3e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EWC47859.1 - 0.086 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sporozoite_P67 PF05642.11 EWC47860.1 - 5.8 4.9 7.9 8.1 4.4 7.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Peptidase_S8 PF00082.22 EWC47862.1 - 2.7e-34 118.8 5.4 5.3e-34 117.8 5.4 1.4 1 1 0 1 1 1 1 Subtilase family Peptidase_M22 PF00814.25 EWC47863.1 - 3.8e-11 43.2 0.0 4.4e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family FGGY_C PF02782.16 EWC47863.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Patatin PF01734.22 EWC47863.1 - 0.14 12.3 0.0 0.17 12.1 0.0 1.1 1 0 0 1 1 1 0 Patatin-like phospholipase Myb_DNA-binding PF00249.31 EWC47864.1 - 3.9e-23 81.4 0.2 1.6e-11 44.2 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EWC47864.1 - 5.8e-15 55.3 0.2 2.8e-11 43.5 0.0 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Glyco_transf_41 PF13844.6 EWC47865.1 - 4.3e-98 328.8 0.0 1.1e-47 162.6 0.0 3.6 3 1 1 4 4 4 2 Glycosyl transferase family 41 TPR_1 PF00515.28 EWC47865.1 - 3.8e-20 70.8 1.7 0.00018 21.2 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47865.1 - 3.5e-19 67.3 0.9 0.00078 19.4 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EWC47865.1 - 2.5e-15 55.3 1.3 0.0013 18.8 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EWC47865.1 - 1e-14 53.9 2.5 0.00045 19.8 0.1 5.3 4 1 2 6 6 6 3 TPR repeat TPR_17 PF13431.6 EWC47865.1 - 1.1e-12 47.4 1.2 0.012 15.9 0.0 5.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 EWC47865.1 - 6.2e-11 41.8 5.2 0.0025 17.6 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47865.1 - 8.9e-11 42.3 3.2 0.0039 17.8 0.2 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47865.1 - 1.2e-10 41.3 1.7 0.0037 17.9 0.1 5.6 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 EWC47865.1 - 8.7e-10 39.0 1.7 0.011 16.2 0.0 3.6 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 EWC47865.1 - 2.1e-09 36.7 0.8 0.013 15.4 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EWC47865.1 - 1.7e-08 34.6 3.8 0.00017 21.8 0.2 4.9 3 2 0 3 3 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 EWC47865.1 - 0.00038 20.9 0.4 49 4.9 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EWC47865.1 - 0.0044 17.1 0.8 0.16 12.1 0.1 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat BTAD PF03704.17 EWC47865.1 - 0.029 14.8 0.1 0.93 9.9 0.0 2.8 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_15 PF13429.6 EWC47865.1 - 0.038 13.2 0.0 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Mito_carr PF00153.27 EWC47866.1 - 1.4e-70 233.3 1.2 1.6e-23 82.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EWC47866.1 - 2.3e-13 50.4 0.7 5.7e-05 23.5 0.1 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EWC47866.1 - 5.8e-11 41.4 0.1 0.00093 18.9 0.0 5.6 7 0 0 7 7 7 2 EF-hand domain EF-hand_8 PF13833.6 EWC47866.1 - 2.9e-10 39.8 0.0 0.0029 17.4 0.0 4.4 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 EWC47866.1 - 3.1e-10 38.9 0.2 0.0044 16.5 0.0 5.5 6 0 0 6 6 6 2 EF hand EF-hand_9 PF14658.6 EWC47866.1 - 0.011 16.0 0.0 9 6.7 0.0 4.0 4 0 0 4 4 4 0 EF-hand domain RPN7 PF10602.9 EWC47867.1 - 2.1e-45 154.5 0.6 4.2e-45 153.6 0.6 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EWC47867.1 - 9.1e-20 71.1 0.2 6.5e-19 68.4 0.0 2.4 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 EWC47867.1 - 2.8 8.3 7.1 28 5.1 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Glucodextran_B PF09136.10 EWC47868.1 - 0.12 12.8 4.7 0.94 9.9 0.0 3.1 3 0 0 3 3 3 0 Glucodextranase, domain B PQ-loop PF04193.14 EWC47869.1 - 3.1e-23 81.3 22.9 9.1e-13 47.8 2.0 2.7 3 0 0 3 3 3 2 PQ loop repeat Polysacc_synt PF01943.17 EWC47869.1 - 0.017 14.5 1.1 0.017 14.5 1.1 2.5 3 1 0 3 3 3 0 Polysaccharide biosynthesis protein DUF2613 PF11021.8 EWC47869.1 - 0.069 13.3 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) MASE2 PF05230.11 EWC47869.1 - 0.13 12.4 4.1 14 5.8 0.1 3.8 3 1 0 3 3 3 0 MASE2 domain SET PF00856.28 EWC47870.1 - 1.5e-14 54.8 0.0 4.6e-14 53.2 0.0 1.8 1 1 0 1 1 1 1 SET domain CH PF00307.31 EWC47873.1 - 7.9e-08 32.5 0.0 3.5e-07 30.4 0.0 2.1 3 0 0 3 3 3 1 Calponin homology (CH) domain IQ PF00612.27 EWC47873.1 - 7.1e-05 22.3 14.1 0.0054 16.4 0.8 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif AAA PF00004.29 EWC47874.1 - 5e-52 175.8 0.0 2.1e-43 147.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC47874.1 - 2.2e-09 37.0 0.3 9.8e-09 34.9 0.0 2.2 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 EWC47874.1 - 9.6e-08 32.6 0.1 0.00015 22.2 0.0 3.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 EWC47874.1 - 2.5e-06 27.7 0.0 6.8e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EWC47874.1 - 1.6e-05 24.7 0.0 9.4e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 EWC47874.1 - 0.00033 20.8 0.0 1.3 9.1 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.14 EWC47874.1 - 0.00041 20.4 0.0 0.0014 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EWC47874.1 - 0.00052 20.3 0.4 0.048 13.9 0.1 3.8 2 2 1 3 3 3 1 AAA domain RNA_helicase PF00910.22 EWC47874.1 - 0.0038 17.6 0.0 0.015 15.7 0.0 2.1 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EWC47874.1 - 0.0045 17.5 0.0 0.019 15.5 0.0 2.2 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EWC47874.1 - 0.0081 16.7 0.5 0.075 13.5 0.0 2.9 3 0 0 3 3 3 1 ABC transporter AAA_33 PF13671.6 EWC47874.1 - 0.0084 16.3 0.0 0.034 14.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EWC47874.1 - 0.009 15.2 0.0 0.02 14.1 0.0 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 EWC47874.1 - 0.022 14.5 0.0 0.091 12.5 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EWC47874.1 - 0.024 14.3 0.0 1.3 8.7 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 EWC47874.1 - 0.039 13.7 0.1 0.13 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EWC47874.1 - 0.055 12.9 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EWC47874.1 - 0.059 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 EWC47874.1 - 0.18 11.9 0.0 1.7 8.8 0.0 2.1 2 0 0 2 2 2 0 Torsin Glyco_hydro_45 PF02015.16 EWC47877.1 - 1.1e-37 130.0 9.0 1.4e-37 129.7 9.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Metallophos PF00149.28 EWC47879.1 - 3.2e-10 40.8 0.3 5.5e-10 40.1 0.3 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EWC47879.1 - 0.0045 17.2 0.0 0.038 14.2 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_76 PF03663.14 EWC47880.1 - 4.3e-15 56.1 0.7 4.8e-09 36.2 0.1 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 zf-PHD-like PF15446.6 EWC47882.1 - 0.039 13.6 0.1 0.092 12.4 0.0 1.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Tfb4 PF03850.14 EWC47883.1 - 1.4e-93 313.4 0.0 1.7e-93 313.1 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Asparaginase_2 PF01112.18 EWC47884.1 - 4.8e-51 173.6 0.1 8.6e-51 172.8 0.1 1.4 1 0 0 1 1 1 1 Asparaginase Actin PF00022.19 EWC47885.1 - 9.9e-89 297.8 0.0 3.5e-86 289.4 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EWC47885.1 - 0.014 14.2 0.0 0.68 8.7 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein CM_2 PF01817.21 EWC47887.1 - 0.0076 16.6 0.2 2.7 8.4 0.1 2.6 2 0 0 2 2 2 2 Chorismate mutase type II zf-ZPR1 PF03367.13 EWC47888.1 - 1.6e-113 375.8 0.1 1.5e-55 187.4 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zinc-ribbons_6 PF07191.12 EWC47888.1 - 0.037 14.0 2.6 0.46 10.5 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbons zf-RRPl_C4 PF17026.5 EWC47888.1 - 0.047 13.8 0.8 5.7 7.1 0.1 2.4 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type Cytochrome_C7 PF14522.6 EWC47888.1 - 0.098 12.7 3.7 0.15 12.1 0.4 2.6 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c Haem_bd PF14376.6 EWC47888.1 - 0.16 11.9 0.8 4.3 7.3 0.0 2.4 1 1 1 2 2 2 0 Haem-binding domain Ribosomal_L32p PF01783.23 EWC47888.1 - 4.4 7.6 5.7 4.1 7.7 0.2 3.2 4 0 0 4 4 4 0 Ribosomal L32p protein family F-box PF00646.33 EWC47889.1 - 0.019 14.9 0.6 0.072 13.0 0.1 2.2 2 0 0 2 2 2 0 F-box domain Trypsin_2 PF13365.6 EWC47890.1 - 0.01 16.7 0.2 0.038 14.9 0.1 2.0 1 1 1 2 2 2 0 Trypsin-like peptidase domain Peptidase_S32 PF05579.13 EWC47890.1 - 0.02 14.1 0.0 2.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S64 PF08192.11 EWC47890.1 - 0.16 10.4 0.3 9.4 4.6 0.2 2.3 2 1 0 2 2 2 0 Peptidase family S64 IBR PF01485.21 EWC47891.1 - 4.4e-06 26.8 21.7 0.0016 18.6 1.1 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 EWC47891.1 - 0.00012 21.8 3.7 0.00012 21.8 3.7 3.7 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC47891.1 - 0.0019 18.2 7.3 0.0019 18.2 7.3 2.4 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 EWC47891.1 - 0.0066 16.8 7.1 0.0066 16.8 7.1 3.7 3 2 0 3 3 3 1 Ring finger domain FYVE PF01363.21 EWC47891.1 - 0.018 15.1 3.9 0.018 15.1 3.9 3.4 2 1 0 2 2 2 0 FYVE zinc finger zf-RING_5 PF14634.6 EWC47891.1 - 0.027 14.4 7.8 0.027 14.4 7.8 3.3 2 1 1 3 3 3 0 zinc-RING finger domain DUF2561 PF10812.8 EWC47891.1 - 0.086 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) zf-ACC PF17848.1 EWC47891.1 - 0.09 12.9 0.4 0.09 12.9 0.4 3.3 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain Zn_Tnp_IS91 PF14319.6 EWC47891.1 - 3.3 7.8 20.2 3.7 7.6 1.9 3.6 3 0 0 3 3 3 0 Transposase zinc-binding domain zf-RING_11 PF17123.5 EWC47891.1 - 4.3 7.2 9.2 0.69 9.7 4.2 2.3 2 0 0 2 2 2 0 RING-like zinc finger HET PF06985.11 EWC47892.1 - 1e-13 51.9 1.9 1.1e-12 48.6 0.1 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) BHD_2 PF10404.9 EWC47893.1 - 0.045 14.7 0.0 0.11 13.5 0.0 1.7 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 2 FbpA PF05833.11 EWC47893.1 - 0.061 12.1 0.8 0.11 11.2 0.8 1.5 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DMP1 PF07263.11 EWC47893.1 - 0.85 8.5 11.3 1.2 8.0 11.3 1.1 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) zf-C3HC4_2 PF13923.6 EWC47894.1 - 0.0018 18.1 3.9 0.0036 17.1 3.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC47894.1 - 0.0033 17.7 7.5 0.0069 16.7 7.5 1.6 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EWC47894.1 - 0.01 15.7 7.8 0.019 14.8 7.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC47894.1 - 0.077 13.0 8.3 0.18 11.8 8.4 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 EWC47894.1 - 0.84 9.7 8.4 1.4 9.0 8.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger GFA PF04828.14 EWC47895.1 - 1.9e-17 63.4 15.0 1.5e-09 38.0 0.6 3.1 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme Glyco_hydro_98M PF08306.11 EWC47895.1 - 0.026 13.8 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 zf-RRN7 PF11781.8 EWC47895.1 - 0.12 12.1 0.5 0.12 12.1 0.5 4.9 5 1 0 5 5 5 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 HHH PF00633.23 EWC47896.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Peptidase_U4 PF03419.13 EWC47896.1 - 1.3 8.3 14.0 0.065 12.5 5.7 2.0 1 1 1 2 2 2 0 Sporulation factor SpoIIGA TrbC PF04956.13 EWC47896.1 - 2.5 8.4 11.6 15 5.9 4.4 2.6 1 1 1 2 2 2 0 TrbC/VIRB2 family TssO PF17561.2 EWC47896.1 - 2.6 8.2 6.2 66 3.6 0.0 2.6 2 1 1 3 3 3 0 Type VI secretion system, TssO CENP-H PF05837.12 EWC47898.1 - 0.067 13.6 2.2 0.12 12.8 1.5 1.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ZnuA PF01297.17 EWC47898.1 - 0.72 9.2 3.7 2.9 7.2 1.2 2.4 1 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic Met_10 PF02475.16 EWC47899.1 - 0.0004 20.2 0.0 0.00067 19.5 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Fanconi_A PF03511.14 EWC47899.1 - 0.03 14.2 0.0 0.67 9.9 0.0 2.3 2 0 0 2 2 2 0 Fanconi anaemia group A protein EF-hand_6 PF13405.6 EWC47900.1 - 1.3e-07 31.0 0.2 0.0016 18.2 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EWC47900.1 - 1.1e-06 29.0 0.1 2.9e-06 27.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EWC47900.1 - 8.1e-06 25.1 0.0 2e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EWC47900.1 - 1.2e-05 24.5 0.1 3.3e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EWC47900.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair SHOCT PF09851.9 EWC47900.1 - 0.37 10.6 0.1 0.37 10.6 0.1 1.8 2 0 0 2 2 2 0 Short C-terminal domain ubiquitin PF00240.23 EWC47901.1 - 1.3e-06 28.1 0.1 1.7e-06 27.7 0.1 1.3 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EWC47901.1 - 0.011 15.5 0.1 0.016 15.0 0.1 1.3 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EWC47901.1 - 0.013 16.0 0.0 0.062 13.8 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain CLP1_P PF16575.5 EWC47902.1 - 4.5e-39 134.2 0.0 1.4e-38 132.6 0.0 1.8 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EWC47902.1 - 1.9e-31 108.1 0.0 3e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EWC47902.1 - 1.4e-23 83.5 0.0 2.1e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.17 EWC47902.1 - 0.0032 17.3 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EWC47902.1 - 0.018 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EWC47902.1 - 0.033 13.9 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EWC47902.1 - 0.034 14.6 0.1 0.065 13.7 0.1 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EWC47902.1 - 0.052 14.1 0.0 0.097 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter SRP54 PF00448.22 EWC47902.1 - 0.056 13.1 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EWC47902.1 - 0.058 13.5 0.0 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase DBR1 PF05011.13 EWC47903.1 - 5.7e-37 127.2 0.1 9.9e-37 126.5 0.1 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EWC47903.1 - 5.9e-09 36.7 0.0 1.1e-08 35.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase UNC45-central PF11701.8 EWC47904.1 - 4e-29 101.5 4.1 1.4e-28 99.8 0.1 3.9 5 1 0 5 5 5 1 Myosin-binding striated muscle assembly central Arm PF00514.23 EWC47904.1 - 3.7e-08 33.1 12.3 0.035 14.1 0.0 7.7 9 0 0 9 9 9 2 Armadillo/beta-catenin-like repeat TPR_2 PF07719.17 EWC47904.1 - 0.0051 16.8 0.2 0.0051 16.8 0.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47904.1 - 0.0074 17.0 1.4 0.0074 17.0 1.4 4.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EWC47904.1 - 0.012 15.2 0.0 0.034 13.8 0.0 1.8 1 0 0 1 1 1 0 TPR repeat TPR_16 PF13432.6 EWC47904.1 - 0.02 15.5 0.5 0.02 15.5 0.5 4.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47904.1 - 0.11 12.4 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat RNA_pol_Rpb8 PF03870.15 EWC47905.1 - 3.9e-40 137.3 0.1 4.4e-40 137.1 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EWC47905.1 - 4.8e-08 33.1 0.5 0.0062 16.6 0.1 2.1 1 1 1 2 2 2 2 DNA-directed RNA polymerase, subunit G DUF4743 PF15916.5 EWC47906.1 - 7.1e-17 61.5 0.0 1.8e-16 60.2 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 EWC47906.1 - 4.5e-07 30.0 0.0 8e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain MoCF_biosynth PF00994.24 EWC47907.1 - 1.1e-59 200.2 1.1 2e-29 102.1 0.1 2.6 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EWC47907.1 - 3.1e-39 134.3 5.2 5.1e-39 133.6 5.2 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 EWC47907.1 - 7.5e-11 42.1 0.2 2.4e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 MoeA C-terminal region (domain IV) MAS20 PF02064.15 EWC47908.1 - 2.8e-43 147.1 2.1 3.4e-43 146.8 2.1 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor DUF4148 PF13663.6 EWC47908.1 - 0.73 10.1 5.2 3.5 7.9 5.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4148) WD40 PF00400.32 EWC47909.1 - 1.6e-13 50.9 5.1 0.0042 17.9 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC47909.1 - 0.034 14.4 0.0 13 6.1 0.0 4.1 3 2 3 6 6 6 0 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EWC47909.1 - 0.057 11.7 0.0 0.11 10.8 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 EWC47909.1 - 0.19 10.7 0.0 15 4.4 0.0 2.5 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Trypsin_2 PF13365.6 EWC47911.1 - 1e-26 94.7 0.2 1.7e-26 93.9 0.2 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S46 PF10459.9 EWC47911.1 - 0.00053 18.8 0.0 0.00099 17.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase S46 OTU PF02338.19 EWC47912.1 - 3.1e-13 50.3 0.0 5.9e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EWC47912.1 - 0.012 15.1 0.8 0.83 9.1 0.0 2.7 1 1 1 2 2 2 0 Peptidase C65 Otubain DUF5614 PF18474.1 EWC47912.1 - 0.022 14.1 1.2 0.039 13.3 1.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5614) UBA_4 PF14555.6 EWC47912.1 - 0.039 13.8 0.0 0.075 12.9 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain CDC45 PF02724.14 EWC47912.1 - 0.46 8.7 15.3 0.69 8.1 15.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 EWC47912.1 - 2 6.4 9.0 2.7 6.0 9.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BSP_II PF05432.11 EWC47912.1 - 2.6 7.6 17.2 4.8 6.8 17.2 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Thioredoxin PF00085.20 EWC47913.1 - 5.4e-25 87.4 0.1 7.2e-25 87.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EWC47913.1 - 8e-06 25.6 0.0 1.1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EWC47913.1 - 2.8e-05 24.5 0.1 0.00019 21.9 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EWC47913.1 - 0.00045 20.5 0.0 0.0012 19.1 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 EWC47913.1 - 0.00055 19.4 0.0 0.00069 19.0 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EWC47913.1 - 0.0027 17.6 0.0 0.0039 17.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.24 EWC47913.1 - 0.0038 17.4 0.2 0.0061 16.8 0.2 1.3 1 0 0 1 1 1 1 Glutaredoxin Redoxin PF08534.10 EWC47913.1 - 0.031 14.0 0.1 0.29 10.8 0.1 2.0 1 1 1 2 2 2 0 Redoxin TraF PF13728.6 EWC47913.1 - 0.058 13.2 0.0 0.085 12.7 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Phosducin PF02114.16 EWC47913.1 - 0.12 11.2 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Phosducin DAO PF01266.24 EWC47916.1 - 9.9e-34 117.4 0.6 1.1e-33 117.3 0.6 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EWC47916.1 - 1.8e-05 24.8 1.8 4.2e-05 23.7 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EWC47916.1 - 3.6e-05 23.1 0.7 7.8e-05 22.0 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EWC47916.1 - 4.8e-05 22.6 0.0 6.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EWC47916.1 - 0.00042 19.6 0.4 0.0076 15.5 0.0 2.4 2 1 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EWC47916.1 - 0.0015 19.1 0.4 0.004 17.7 0.4 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EWC47916.1 - 0.0016 17.4 0.4 0.047 12.5 0.2 2.1 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_7 PF13241.6 EWC47916.1 - 0.0021 18.5 0.0 0.0035 17.8 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 EWC47916.1 - 0.0029 17.2 0.3 0.005 16.4 0.3 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 EWC47916.1 - 0.0054 16.0 0.2 0.011 15.0 0.2 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EWC47916.1 - 0.0068 15.2 0.5 0.011 14.5 0.5 1.3 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EWC47916.1 - 0.007 15.5 0.3 0.012 14.8 0.3 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EWC47916.1 - 0.012 14.9 0.2 0.019 14.2 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EWC47916.1 - 0.035 13.2 0.1 0.11 11.5 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein ApbA PF02558.16 EWC47916.1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 EWC47916.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EWC47916.1 - 0.22 11.8 1.4 4.7 7.5 0.2 2.6 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 EWC47916.1 - 0.22 11.4 0.5 0.39 10.6 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Goodbye PF17109.5 EWC47917.1 - 5.5e-15 55.9 0.1 2.9e-14 53.6 0.1 2.4 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain TPR_16 PF13432.6 EWC47917.1 - 1.2e-05 25.8 0.1 0.0055 17.3 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47917.1 - 4.7e-05 23.2 5.4 0.077 13.1 0.2 4.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC47917.1 - 0.0028 17.4 1.7 1 9.3 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat AAA_22 PF13401.6 EWC47917.1 - 0.0033 17.7 1.3 1.7 8.9 0.0 4.0 4 0 0 4 4 4 1 AAA domain TPR_14 PF13428.6 EWC47917.1 - 0.0037 18.0 1.2 0.92 10.5 0.1 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC47917.1 - 0.0038 17.5 5.1 0.02 15.2 1.5 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EWC47917.1 - 0.04 14.0 3.2 8 6.8 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat RRF PF01765.19 EWC47917.1 - 1.7 8.5 9.7 2 8.4 0.0 3.7 4 0 0 4 4 4 0 Ribosome recycling factor Adaptin_N PF01602.20 EWC47918.1 - 3.3e-120 402.1 0.0 3.8e-120 401.9 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EWC47918.1 - 1.1e-12 48.3 0.0 5.3e-11 42.8 0.0 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC47918.1 - 2.5e-10 40.6 2.1 0.00016 22.0 0.0 4.9 3 3 1 4 4 4 3 HEAT repeats HEAT PF02985.22 EWC47918.1 - 3.9e-05 23.6 1.5 0.77 10.2 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EWC47918.1 - 0.0016 18.9 1.0 32 5.2 0.2 4.7 4 0 0 4 4 4 0 HEAT-like repeat Cnd3 PF12719.7 EWC47918.1 - 0.0071 15.6 0.1 0.036 13.3 0.0 2.2 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain DUF2722 PF10846.8 EWC47918.1 - 2.5 6.9 18.8 1.4 7.7 16.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SDA1 PF05285.12 EWC47918.1 - 5.4 6.4 31.7 8.6 5.7 31.7 1.2 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 EWC47918.1 - 7.8 6.0 30.3 5.1 6.6 28.3 1.6 2 0 0 2 2 2 0 PPP4R2 TPR_12 PF13424.6 EWC47919.1 - 6e-13 48.9 8.1 8.2e-09 35.6 1.7 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EWC47919.1 - 5.8e-06 26.0 8.5 0.0026 17.6 0.3 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat Clr5 PF14420.6 EWC47919.1 - 2e-05 24.7 0.1 4.8e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Clr5 domain TPR_19 PF14559.6 EWC47919.1 - 0.0039 17.7 8.6 0.76 10.3 1.3 4.2 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EWC47919.1 - 0.038 14.6 7.7 0.65 10.7 0.9 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EWC47919.1 - 0.2 12.6 6.3 5.3 8.1 0.1 4.1 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EWC47919.1 - 1.6 9.0 7.8 2.4 8.5 1.6 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Metallophos PF00149.28 EWC47921.1 - 5.2e-37 128.3 0.8 6.6e-37 128.0 0.8 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Nuc_recep-AF1 PF11825.8 EWC47922.1 - 0.095 12.8 5.0 0.71 9.9 0.2 2.4 2 0 0 2 2 2 0 Nuclear/hormone receptor activator site AF-1 HlyIII PF03006.20 EWC47923.1 - 8.7e-44 149.9 11.5 1.1e-43 149.5 11.5 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.11 EWC47923.1 - 0.0065 16.5 0.9 0.23 11.6 1.9 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF962) Exo84_C PF16528.5 EWC47924.1 - 6.5e-60 202.5 2.5 1.5e-59 201.3 1.1 2.2 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EWC47924.1 - 1.5e-15 57.0 2.8 4.2e-15 55.6 2.8 1.8 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 EWC47924.1 - 0.016 15.3 2.4 0.017 15.2 0.3 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Gly_reductase PF09338.11 EWC47924.1 - 0.23 9.8 0.0 0.35 9.2 0.0 1.1 1 0 0 1 1 1 0 Glycine/sarcosine/betaine reductase component B subunits DUF3357 PF11837.8 EWC47925.1 - 0.041 14.4 0.4 0.14 12.6 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) TatC PF00902.18 EWC47925.1 - 0.2 11.5 1.7 0.29 10.9 1.7 1.3 1 1 0 1 1 1 0 Sec-independent protein translocase protein (TatC) HemY_N PF07219.13 EWC47926.1 - 0.054 13.7 0.5 0.081 13.1 0.5 1.5 1 1 0 1 1 1 0 HemY protein N-terminus PAXNEB PF05625.11 EWC47927.1 - 6.3e-92 308.6 0.0 9.2e-92 308.0 0.0 1.2 1 0 0 1 1 1 1 PAXNEB protein Metallophos PF00149.28 EWC47930.1 - 5.6e-37 128.2 0.2 8.3e-37 127.7 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EWC47930.1 - 0.0028 18.1 0.7 0.007 16.8 0.7 1.6 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 EWC47930.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain ATP_bind_1 PF03029.17 EWC47931.1 - 5.8e-79 265.3 0.0 7.1e-79 265.0 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_31 PF13614.6 EWC47931.1 - 0.0051 16.7 0.0 0.51 10.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EWC47931.1 - 0.0055 16.8 0.0 0.0093 16.0 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 EWC47931.1 - 0.0063 15.5 0.0 0.015 14.3 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 EWC47931.1 - 0.039 13.4 0.0 0.091 12.2 0.0 1.7 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 EWC47931.1 - 0.046 13.5 0.0 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_33 PF13671.6 EWC47931.1 - 0.048 13.8 0.0 0.048 13.8 0.0 1.9 2 1 0 2 2 1 0 AAA domain AAA_10 PF12846.7 EWC47931.1 - 0.049 12.5 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.6 EWC47931.1 - 0.053 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EWC47931.1 - 0.064 13.6 0.0 0.21 12.0 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain KTI12 PF08433.10 EWC47931.1 - 0.068 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 MMR_HSR1 PF01926.23 EWC47931.1 - 0.078 13.1 0.1 2.2 8.4 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 EWC47931.1 - 0.089 13.1 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain TPH PF13868.6 EWC47931.1 - 0.1 11.1 9.4 0.14 10.7 9.4 1.1 1 0 0 1 1 1 0 Trichohyalin-plectin-homology domain Sigma54_activ_2 PF14532.6 EWC47931.1 - 0.18 11.9 0.1 5.8 7.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_29 PF13555.6 EWC47931.1 - 0.18 11.6 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.6 EWC47931.1 - 0.19 12.1 0.1 0.19 12.1 0.1 2.1 2 0 0 2 2 2 0 AAA domain NDUF_B4 PF07225.12 EWC47932.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) RNase_P_Rpp14 PF01900.19 EWC47933.1 - 4.8e-36 123.1 0.0 6.8e-36 122.6 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family Pik1 PF11522.8 EWC47935.1 - 0.31 11.0 1.2 4.5 7.3 0.1 2.3 2 0 0 2 2 2 0 Yeast phosphatidylinositol-4-OH kinase Pik1 Vint PF14623.6 EWC47936.1 - 8.2e-53 178.6 0.0 1.2e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.6 EWC47936.1 - 4.6e-25 87.5 0.0 9.3e-25 86.6 0.0 1.5 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA_3 PF13768.6 EWC47936.1 - 7.4e-12 45.5 0.0 2.9e-11 43.5 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EWC47936.1 - 1.2e-11 45.2 0.3 4.7e-11 43.3 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EWC47936.1 - 6.9e-10 39.4 0.0 2.1e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain Hint PF01079.20 EWC47936.1 - 0.0017 17.9 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 Hint module Orn_DAP_Arg_deC PF00278.22 EWC47936.1 - 0.029 14.6 0.0 0.14 12.4 0.0 2.1 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain adh_short PF00106.25 EWC47939.1 - 1.4e-21 76.8 0.2 2.9e-18 66.1 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC47939.1 - 7.9e-10 38.7 0.2 3.4e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC47939.1 - 3e-06 27.3 0.1 4.9e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EWC47939.1 - 0.0029 17.1 0.1 0.0058 16.1 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DSPc PF00782.20 EWC47940.1 - 4.4e-31 107.4 0.0 1.2e-21 76.9 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EWC47940.1 - 0.00011 21.8 0.0 0.0051 16.4 0.0 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase HTH_17 PF12728.7 EWC47940.1 - 0.13 12.4 0.1 0.37 11.0 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3112 PF11309.8 EWC47941.1 - 5.2e-09 35.9 0.5 5.2e-09 35.9 0.5 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) GDPD PF03009.17 EWC47942.1 - 1.6e-74 250.9 0.0 2.8e-74 250.1 0.0 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EWC47942.1 - 2.3e-28 98.6 0.2 1.7e-16 60.6 0.1 3.7 4 0 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC47942.1 - 6e-21 74.5 0.9 7.6e-06 26.4 0.1 5.5 5 0 0 5 5 5 3 Ankyrin repeats (many copies) SPX PF03105.19 EWC47942.1 - 1.9e-20 74.2 14.5 8.3e-11 42.4 0.2 3.8 2 1 2 4 4 4 3 SPX domain Ank PF00023.30 EWC47942.1 - 8.1e-16 57.7 3.3 0.032 14.7 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EWC47942.1 - 8.9e-16 56.4 1.5 0.0069 16.8 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EWC47942.1 - 1.2e-15 57.3 0.1 5.5e-05 23.4 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeats (many copies) OB_NTP_bind PF07717.16 EWC47943.1 - 2.5e-25 88.6 0.0 4.5e-23 81.4 0.0 3.0 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EWC47943.1 - 1.4e-19 70.3 0.0 3.3e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EWC47943.1 - 7.6e-11 42.3 0.0 2.8e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EWC47943.1 - 1.1e-08 35.1 0.2 2.6e-08 33.8 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EWC47943.1 - 0.00012 22.3 0.4 0.00035 20.9 0.1 1.9 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 EWC47943.1 - 0.00033 20.6 0.1 0.00075 19.5 0.1 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.6 EWC47943.1 - 0.00044 20.6 0.2 0.00088 19.6 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC47943.1 - 0.00045 20.0 0.0 0.00079 19.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EWC47943.1 - 0.0065 16.1 0.3 0.03 13.9 0.3 2.2 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain ResIII PF04851.15 EWC47943.1 - 0.0077 16.2 0.1 0.59 10.1 0.1 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EWC47943.1 - 0.022 13.8 0.0 0.053 12.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EWC47943.1 - 0.1 13.1 0.0 0.46 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EWC47943.1 - 0.1 12.1 0.0 0.32 10.5 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region RTP1_C1 PF10363.9 EWC47944.1 - 1.5e-32 112.1 0.5 1.2e-31 109.1 0.1 2.9 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EWC47944.1 - 1.6e-06 27.7 1.8 4.1e-06 26.4 1.8 1.7 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 CDC45 PF02724.14 EWC47944.1 - 0.02 13.2 0.0 0.02 13.2 0.0 1.7 2 0 0 2 2 2 0 CDC45-like protein DUF4449 PF14613.6 EWC47944.1 - 0.24 11.5 1.0 0.52 10.4 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) Rieske PF00355.26 EWC47945.1 - 5e-12 45.6 0.1 1e-11 44.6 0.1 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EWC47945.1 - 1.6e-08 34.9 2.5 2e-08 34.6 1.4 1.7 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region LSM PF01423.22 EWC47946.1 - 2e-20 72.3 0.1 2.2e-20 72.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain IBR PF01485.21 EWC47947.1 - 1.1e-05 25.5 23.3 0.0078 16.4 5.9 3.4 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain PI31_Prot_N PF11566.8 EWC47949.1 - 2.2e-47 160.9 0.0 2.7e-47 160.6 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EWC47949.1 - 4e-13 50.3 17.1 4e-13 50.3 17.1 3.3 3 1 0 3 3 3 1 PI31 proteasome regulator zf-C2H2 PF00096.26 EWC47950.1 - 2.6e-08 33.9 14.9 0.0049 17.2 0.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC47950.1 - 0.00025 21.6 13.3 0.051 14.4 0.7 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EWC47950.1 - 0.005 17.0 0.3 0.005 17.0 0.3 2.0 1 1 1 2 2 2 1 Aberrant zinc-finger zf-met PF12874.7 EWC47950.1 - 0.081 13.3 3.1 0.41 11.1 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EWC47950.1 - 0.091 13.1 5.9 0.61 10.4 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Creatininase PF02633.14 EWC47950.1 - 0.12 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Creatinine amidohydrolase zf-H2C2_2 PF13465.6 EWC47950.1 - 0.16 12.5 21.0 0.64 10.6 6.0 3.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_8 PF15909.5 EWC47950.1 - 8 6.8 11.0 2.3 8.5 7.2 2.2 2 1 0 2 2 2 0 C2H2-type zinc ribbon PAT1 PF09770.9 EWC47951.1 - 7.9e-260 864.8 5.1 9.4e-260 864.5 5.1 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Glyco_transf_15 PF01793.16 EWC47952.1 - 9.5e-130 432.6 6.9 1.1e-129 432.3 6.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase EGF_3 PF12947.7 EWC47952.1 - 0.018 15.2 1.7 0.035 14.3 1.7 1.5 1 0 0 1 1 1 0 EGF domain Ribosom_S12_S23 PF00164.25 EWC47953.1 - 2.1e-29 101.5 0.6 2.7e-29 101.1 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 She9_MDM33 PF05546.11 EWC47954.1 - 8.3e-72 241.2 8.4 1.3e-71 240.5 8.4 1.3 1 0 0 1 1 1 1 She9 / Mdm33 family Dynactin_p62 PF05502.13 EWC47954.1 - 0.073 11.8 1.3 0.11 11.2 1.3 1.2 1 0 0 1 1 1 0 Dynactin p62 family Arrestin_C PF02752.22 EWC47955.1 - 2.6e-13 50.6 0.0 7.7e-13 49.1 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Peptidase_C48 PF02902.19 EWC47956.1 - 6.9e-27 94.7 0.0 1.1e-26 94.0 0.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Skp1_POZ PF03931.15 EWC47957.1 - 6e-08 32.7 0.0 6e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 EWC47957.1 - 0.065 13.5 0.2 0.11 12.7 0.2 1.4 1 1 0 1 1 1 0 BTB/POZ domain tRNA_int_end_N2 PF12928.7 EWC47958.1 - 5.2e-23 81.0 0.1 9.3e-23 80.2 0.1 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term HAD PF12710.7 EWC47959.1 - 1.7e-19 71.0 0.0 2.2e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EWC47959.1 - 6e-05 22.5 0.0 0.00019 20.9 0.0 1.7 1 1 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 EWC47959.1 - 0.003 17.1 0.0 0.0052 16.3 0.0 1.5 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Voltage_CLC PF00654.20 EWC47960.1 - 6.7e-88 295.3 25.6 6.7e-88 295.3 25.6 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EWC47960.1 - 1.7e-13 50.8 0.1 7e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain CBFD_NFYB_HMF PF00808.23 EWC47961.1 - 4.5e-11 42.9 0.1 9.1e-11 41.9 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PPR_2 PF13041.6 EWC47962.1 - 4.2e-05 23.7 0.1 9.9e-05 22.5 0.1 1.7 1 0 0 1 1 1 1 PPR repeat family PPR_3 PF13812.6 EWC47962.1 - 0.0034 17.4 0.2 0.86 9.7 0.0 2.5 2 0 0 2 2 2 2 Pentatricopeptide repeat domain SNARE PF05739.19 EWC47963.1 - 3.4e-11 42.9 0.8 7e-11 42.0 0.8 1.5 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.9 EWC47963.1 - 0.0015 18.3 0.8 0.004 16.9 0.8 1.6 1 1 0 1 1 1 1 Membrane fusion protein Use1 Enkurin PF13864.6 EWC47963.1 - 0.0029 18.0 1.7 0.01 16.3 0.1 2.2 2 0 0 2 2 2 1 Calmodulin-binding ABC_tran_CTD PF16326.5 EWC47963.1 - 0.024 14.9 1.3 0.024 14.9 1.3 2.0 2 1 1 3 3 3 0 ABC transporter C-terminal domain ATG16 PF08614.11 EWC47963.1 - 0.025 14.8 8.0 0.18 12.0 0.6 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) SlyX PF04102.12 EWC47963.1 - 0.12 13.0 12.5 16 6.2 0.0 4.1 2 2 2 4 4 4 0 SlyX DUF745 PF05335.13 EWC47963.1 - 0.2 11.3 3.6 1.8 8.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) YscO PF07321.12 EWC47963.1 - 1 9.3 8.4 2.3 8.2 2.2 2.8 3 0 0 3 3 3 0 Type III secretion protein YscO DUF16 PF01519.16 EWC47963.1 - 2.4 8.7 7.2 0.55 10.7 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4407 PF14362.6 EWC47963.1 - 2.8 7.2 7.9 32 3.7 7.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Pro_dh-DNA_bdg PF14850.6 EWC47964.1 - 0.092 13.3 0.1 0.15 12.6 0.1 1.3 1 0 0 1 1 1 0 DNA-binding domain of Proline dehydrogenase DUF4452 PF14618.6 EWC47965.1 - 4e-43 147.2 6.8 5.1e-43 146.9 6.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) Cyclin_N PF00134.23 EWC47966.1 - 7.1e-13 48.4 2.6 2.3e-11 43.5 0.8 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EWC47966.1 - 0.00038 20.8 1.0 0.0016 18.8 0.4 2.2 2 1 0 2 2 2 1 Cyclin C-terminal domain TFIIB PF00382.19 EWC47966.1 - 0.066 13.3 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Mito_carr PF00153.27 EWC47967.1 - 3.2e-62 206.5 2.7 1.3e-23 82.8 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EWC47967.1 - 2.5e-23 82.3 3.7 1e-11 45.1 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EWC47967.1 - 2.5e-22 76.7 5.7 4.3e-06 25.9 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EWC47967.1 - 1.1e-19 68.7 9.7 6.8e-05 22.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EWC47967.1 - 2.1e-16 58.6 6.5 3.6e-06 26.2 0.7 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EWC47967.1 - 2e-12 46.7 4.5 4e-05 23.4 0.4 3.8 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EWC47967.1 - 8.8e-11 42.1 0.1 0.00033 20.9 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EWC47967.1 - 3.1e-05 24.2 0.0 0.023 15.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.6 EWC47967.1 - 0.0022 17.8 2.5 0.58 10.1 0.1 3.4 2 1 2 4 4 4 2 EF hand EF-hand_4 PF12763.7 EWC47967.1 - 0.0037 17.2 2.0 0.46 10.5 0.3 2.9 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EWC47967.1 - 0.046 14.1 0.2 0.22 11.9 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain PT-VENN PF04829.13 EWC47967.1 - 0.27 11.3 3.5 3.1 8.0 0.0 3.1 3 0 0 3 3 3 0 Pre-toxin domain with VENN motif HORMA PF02301.18 EWC47968.1 - 1.6e-10 40.9 0.0 1.9e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 HORMA domain IBN_N PF03810.19 EWC47969.1 - 3.7e-15 55.6 0.0 4.6e-13 48.9 0.0 3.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT PF02985.22 EWC47969.1 - 6.4e-07 29.1 0.1 0.0063 16.7 0.1 4.4 2 0 0 2 2 2 2 HEAT repeat Xpo1 PF08389.12 EWC47969.1 - 4.5e-05 23.5 0.1 0.00032 20.8 0.0 2.7 2 1 0 2 2 2 1 Exportin 1-like protein Cnd1 PF12717.7 EWC47969.1 - 0.0011 19.0 0.3 0.73 9.9 0.1 3.8 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC47969.1 - 0.0036 17.7 3.6 2.5 8.6 0.1 4.8 4 1 1 5 5 5 2 HEAT repeats Cse1 PF08506.10 EWC47969.1 - 0.038 12.8 0.1 3.4 6.4 0.1 2.4 1 1 1 2 2 2 0 Cse1 Pkinase PF00069.25 EWC47970.1 - 3.5e-22 79.0 0.0 6.9e-22 78.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EWC47970.1 - 4.8e-10 38.8 9.2 0.019 15.2 0.1 6.3 6 0 0 6 6 5 3 HEAT repeat HEAT_2 PF13646.6 EWC47970.1 - 1.2e-08 35.3 0.9 0.054 13.9 0.5 3.5 3 0 0 3 3 3 2 HEAT repeats Pkinase_Tyr PF07714.17 EWC47970.1 - 2.1e-06 27.2 0.0 3.3e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 EWC47970.1 - 2.3e-06 28.2 9.7 0.00014 22.6 0.1 5.9 7 0 0 7 7 5 1 WD domain, G-beta repeat Cnd1 PF12717.7 EWC47970.1 - 9.3e-05 22.5 0.2 0.058 13.4 0.0 3.2 2 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EWC47970.1 - 0.0022 16.6 1.3 0.76 8.3 0.0 2.6 3 0 0 3 3 3 2 Adaptin N terminal region RTP1_C1 PF10363.9 EWC47970.1 - 0.026 14.7 0.0 3.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EWC47970.1 - 0.052 14.1 3.6 0.89 10.1 0.4 3.7 4 0 0 4 4 4 0 HEAT-like repeat Ge1_WD40 PF16529.5 EWC47970.1 - 0.11 11.5 0.1 0.3 10.0 0.0 1.7 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Kinase-like PF14531.6 EWC47970.1 - 0.14 11.5 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like LRR_9 PF14580.6 EWC47971.1 - 6.6e-40 136.4 0.3 1e-39 135.8 0.3 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EWC47971.1 - 3.3e-05 23.5 1.6 9.2e-05 22.1 0.6 2.2 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EWC47971.1 - 0.0066 16.8 6.9 0.086 13.3 0.9 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) GMP_synt_C PF00958.22 EWC47972.1 - 1.5e-42 143.6 0.1 4.9e-42 141.9 0.0 1.9 2 0 0 2 2 2 1 GMP synthase C terminal domain GATase PF00117.28 EWC47972.1 - 3.3e-30 105.3 0.0 7.6e-30 104.1 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EWC47972.1 - 2.2e-10 40.1 0.1 2.5e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EWC47972.1 - 8e-05 22.5 0.0 0.00027 20.7 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 EWC47972.1 - 0.00032 19.6 0.2 0.00072 18.4 0.1 1.6 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 EWC47972.1 - 0.0013 18.2 0.0 0.02 14.4 0.0 2.1 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 EWC47972.1 - 0.0049 16.9 0.0 0.0077 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.19 EWC47972.1 - 0.01 15.2 0.1 0.017 14.4 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ATP_bind_3 PF01171.20 EWC47972.1 - 0.07 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 PP-loop family ThiI PF02568.14 EWC47972.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.5 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) PAP2 PF01569.21 EWC47973.1 - 6.2e-20 71.3 3.0 1.5e-19 70.1 3.0 1.7 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 EWC47973.1 - 2e-06 27.6 2.4 7.1e-06 25.8 2.4 1.9 1 0 0 1 1 1 1 PAP2 superfamily Fer4_5 PF12801.7 EWC47973.1 - 0.047 13.6 0.5 0.047 13.6 0.5 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain PAP2_C PF14360.6 EWC47973.1 - 3.7 8.2 6.8 9.6 6.8 0.8 3.3 3 0 0 3 3 3 0 PAP2 superfamily C-terminal Thr_synth_N PF14821.6 EWC47974.1 - 2.1e-28 98.3 0.0 1.7e-26 92.2 0.0 2.5 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 EWC47974.1 - 3.5e-16 59.5 0.0 1.3e-15 57.6 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PfaD_N PF18328.1 EWC47974.1 - 0.01 15.7 0.0 0.035 14.1 0.0 1.9 1 0 0 1 1 1 0 Fatty acid synthase subunit PfaD N-terminal domain SH3_9 PF14604.6 EWC47975.1 - 1.5e-06 28.0 0.1 3.5e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EWC47975.1 - 0.00041 19.9 0.1 0.00084 18.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain AbiEii PF08843.11 EWC47976.1 - 0.0093 15.9 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system DUF2204 PF09970.9 EWC47976.1 - 0.12 12.1 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF2204) BCIP PF13862.6 EWC47978.1 - 1.7e-65 220.7 0.0 2.1e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein polyprenyl_synt PF00348.17 EWC47979.1 - 7.8e-69 231.6 0.0 4.4e-68 229.1 0.0 1.9 1 1 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EWC47979.1 - 0.024 14.2 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 EI24 PF07264.11 EWC47980.1 - 7.6e-11 42.6 2.3 1.6e-10 41.5 2.3 1.4 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) SYS1 PF09801.9 EWC47981.1 - 6.1e-49 165.9 13.4 7e-49 165.7 13.4 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network YwiC PF14256.6 EWC47981.1 - 0.9 9.9 18.2 0.064 13.6 10.2 2.0 1 1 1 2 2 2 0 YwiC-like protein Acyl_transf_3 PF01757.22 EWC47981.1 - 1.8 7.5 17.7 2.2 7.2 17.7 1.1 1 0 0 1 1 1 0 Acyltransferase family Gti1_Pac2 PF09729.9 EWC47982.1 - 5.2e-46 157.0 1.5 1.8e-37 129.2 0.2 2.1 1 1 1 2 2 2 2 Gti1/Pac2 family tRNA_anti-codon PF01336.25 EWC47983.1 - 1e-08 35.0 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2263 PF10021.9 EWC47984.1 - 1.9e-11 44.6 0.0 2.6e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) PIP5K PF01504.18 EWC47985.1 - 8.9e-97 323.6 0.0 1.5e-96 322.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase WD40 PF00400.32 EWC47986.1 - 2.7e-26 91.3 9.1 2.1e-06 28.4 0.2 6.7 6 1 1 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 EWC47986.1 - 9.4e-08 31.1 11.3 0.0016 17.2 0.2 5.2 3 1 2 6 6 6 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EWC47986.1 - 0.00016 21.9 0.0 2.7 8.3 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain APG6_N PF17675.1 EWC47986.1 - 0.0093 16.5 1.2 0.016 15.7 1.2 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF5082 PF16888.5 EWC47986.1 - 0.11 12.8 0.2 0.22 11.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) HSF_DNA-bind PF00447.17 EWC47988.1 - 3.8e-32 110.8 1.7 6.6e-32 110.0 1.7 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 EWC47988.1 - 8e-20 71.1 0.0 1.7e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain TRPM_tetra PF16519.5 EWC47988.1 - 0.0034 17.4 0.2 0.0061 16.6 0.2 1.3 1 0 0 1 1 1 1 Tetramerisation domain of TRPM AD PF09793.9 EWC47988.1 - 0.41 10.8 1.8 0.87 9.8 0.1 2.2 3 0 0 3 3 3 0 Anticodon-binding domain Adaptin_N PF01602.20 EWC47989.1 - 1.2e-133 446.5 10.3 1.3e-133 446.3 10.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EWC47989.1 - 1.2e-61 207.5 7.8 4.4e-61 205.7 0.6 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EWC47989.1 - 8.5e-18 64.5 5.4 1.1e-06 28.9 0.0 5.9 3 2 5 8 8 8 6 HEAT repeats HEAT PF02985.22 EWC47989.1 - 4.8e-13 48.1 2.7 0.017 15.3 0.0 6.5 6 0 0 6 6 5 3 HEAT repeat HEAT_EZ PF13513.6 EWC47989.1 - 2.5e-07 31.0 0.0 0.22 12.1 0.0 5.9 4 1 1 5 5 5 1 HEAT-like repeat Cnd3 PF12719.7 EWC47989.1 - 0.00046 19.5 1.7 0.0067 15.7 0.2 3.0 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain Arm PF00514.23 EWC47989.1 - 0.00063 19.7 1.1 21 5.4 0.0 5.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EWC47989.1 - 0.0016 18.1 0.2 0.69 9.4 0.0 3.3 2 1 1 3 3 3 1 CLASP N terminal U3snoRNP10 PF12397.8 EWC47989.1 - 0.053 13.9 1.9 0.97 9.8 0.2 3.4 2 2 1 3 3 3 0 U3 small nucleolar RNA-associated protein 10 Sec7_N PF12783.7 EWC47989.1 - 0.26 11.2 2.7 0.48 10.3 0.6 2.6 2 1 1 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Mistic PF11458.8 EWC47989.1 - 1.1 9.3 4.2 22 5.1 0.3 2.8 1 1 1 2 2 2 0 Membrane-integrating protein Mistic BCS1_N PF08740.11 EWC47990.1 - 2.8e-36 125.2 0.1 2.8e-36 125.2 0.1 2.0 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EWC47990.1 - 1.3e-15 58.0 0.0 7.1e-14 52.4 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC47990.1 - 0.023 15.1 0.6 0.085 13.2 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 EWC47990.1 - 0.037 14.0 0.0 0.18 11.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SNF2_N PF00176.23 EWC47991.1 - 3.9e-56 190.3 0.0 9.3e-56 189.0 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EWC47991.1 - 6.2e-46 156.8 1.7 1.3e-45 155.8 1.0 1.8 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 EWC47991.1 - 3.4e-16 59.6 0.0 8.6e-16 58.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC47991.1 - 3.7e-06 27.1 0.0 8.1e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EWC47991.1 - 0.00046 19.4 0.0 0.0029 16.8 0.0 2.2 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 EWC47991.1 - 0.0042 16.3 0.0 0.0074 15.5 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 EWC47991.1 - 0.026 14.8 0.0 18 5.6 0.0 3.0 2 1 0 2 2 2 0 AAA domain Rhomboid_SP PF12595.8 EWC47993.1 - 0.055 12.8 1.5 0.1 12.0 1.5 1.5 1 0 0 1 1 1 0 Rhomboid serine protease WD40 PF00400.32 EWC47994.1 - 5e-13 49.3 3.3 0.0021 18.9 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat WD40_like PF17005.5 EWC47994.1 - 0.097 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain PIN_8 PF18476.1 EWC47994.1 - 0.12 12.2 1.7 0.21 11.4 1.7 1.4 1 0 0 1 1 1 0 PIN like domain SURF6 PF04935.12 EWC47995.1 - 6.5e-48 163.2 38.2 6.5e-48 163.2 38.2 4.6 3 1 0 4 4 4 1 Surfeit locus protein 6 RRP14 PF15459.6 EWC47995.1 - 9.5e-17 61.4 3.2 9.5e-17 61.4 3.2 7.4 6 2 1 8 8 8 1 60S ribosome biogenesis protein Rrp14 COQ9 PF08511.11 EWC47996.1 - 5.2e-22 77.4 0.3 6.2e-22 77.2 0.3 1.1 1 0 0 1 1 1 1 COQ9 RRM_1 PF00076.22 EWC47997.1 - 2.1e-52 174.8 0.0 1.8e-18 66.1 0.0 3.9 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EWC47997.1 - 8.6e-07 28.9 0.0 0.53 10.3 0.0 3.6 3 1 0 3 3 3 3 RNA binding motif RRM_5 PF13893.6 EWC47997.1 - 0.00036 20.1 0.0 0.21 11.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP-grasp_2 PF08442.10 EWC47997.1 - 0.0015 18.1 0.0 0.048 13.2 0.0 2.8 3 0 0 3 3 3 1 ATP-grasp domain Limkain-b1 PF11608.8 EWC47997.1 - 0.0024 17.9 0.0 5.8 7.1 0.0 3.4 3 1 0 3 3 3 2 Limkain b1 PknH_C PF14032.6 EWC47997.1 - 0.022 14.6 0.0 26 4.6 0.0 3.1 3 0 0 3 3 3 0 PknH-like extracellular domain GRP PF07172.11 EWC47997.1 - 6.9 7.4 47.7 14 6.5 0.4 3.6 3 0 0 3 3 3 0 Glycine rich protein family BolA PF01722.18 EWC47998.1 - 4.8e-17 62.0 0.0 1.3e-16 60.6 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein PP-binding PF00550.25 EWC47999.1 - 2.2e-10 40.8 0.1 3.3e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EWC47999.1 - 3.4e-05 24.0 0.1 4.7e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Acyl-carrier GPP34 PF05719.11 EWC48000.1 - 4.1e-44 151.0 0.6 5.1e-44 150.8 0.6 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Ank_2 PF12796.7 EWC48001.1 - 4.1e-23 81.8 0.1 4.1e-12 46.5 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EWC48001.1 - 6e-22 77.4 0.5 7e-08 32.6 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EWC48001.1 - 1.2e-18 67.2 1.7 1.8e-08 34.8 0.1 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EWC48001.1 - 4.4e-18 64.8 0.5 3.9e-05 23.9 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EWC48001.1 - 2e-17 61.5 0.8 0.00014 22.0 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat UCH PF00443.29 EWC48002.1 - 1.2e-43 149.4 0.0 5.8e-43 147.2 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EWC48002.1 - 2.3e-40 136.3 0.5 6.4e-15 54.8 0.0 4.7 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.6 EWC48002.1 - 3.2e-05 23.7 0.1 0.00015 21.5 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4942 PF13708.6 EWC48002.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4942) K_channel_TID PF07941.11 EWC48002.1 - 1.4 9.4 4.8 3 8.3 4.8 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Tim17 PF02466.19 EWC48003.1 - 4.3e-06 27.1 3.8 7.4e-06 26.3 3.4 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Cyt_bd_oxida_II PF02322.15 EWC48003.1 - 0.0064 15.9 0.5 0.008 15.6 0.5 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II AAA_16 PF13191.6 EWC48004.1 - 0.00038 20.9 0.0 0.0018 18.7 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EWC48004.1 - 0.0004 20.3 0.1 0.0069 16.3 0.0 2.8 2 1 0 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 EWC48004.1 - 0.006 16.5 0.2 0.021 14.7 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EWC48004.1 - 0.0069 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EWC48004.1 - 0.0098 16.4 0.1 0.031 14.8 0.1 1.8 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 EWC48004.1 - 0.012 15.4 0.1 0.024 14.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EWC48004.1 - 0.019 15.3 0.0 0.059 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EWC48004.1 - 0.094 13.3 0.4 0.67 10.5 0.1 2.7 3 0 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.23 EWC48004.1 - 0.12 12.5 0.0 0.5 10.5 0.0 2.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase Metal_resist PF13801.6 EWC48004.1 - 0.12 12.6 0.2 0.23 11.6 0.2 1.4 1 0 0 1 1 1 0 Heavy-metal resistance AAA_23 PF13476.6 EWC48004.1 - 0.12 12.8 0.0 0.12 12.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 EWC48004.1 - 0.17 11.9 0.1 2 8.4 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Glyco_hydro_17 PF00332.18 EWC48005.1 - 0.00026 20.7 2.3 0.00087 19.0 2.3 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 SLC35F PF06027.12 EWC48006.1 - 9.3e-102 340.6 26.8 1.1e-101 340.3 26.8 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EWC48006.1 - 4.4e-08 32.5 6.0 4.4e-08 32.5 6.0 1.9 2 1 1 3 3 3 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EWC48006.1 - 0.094 12.9 36.9 0.018 15.2 12.9 2.2 2 0 0 2 2 2 0 EamA-like transporter family OPT PF03169.15 EWC48007.1 - 1.7e-185 618.3 55.6 1.9e-185 618.1 55.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein EIAV_GP90 PF00971.18 EWC48007.1 - 0.0086 14.8 0.4 0.016 13.9 0.4 1.3 1 0 0 1 1 1 1 EIAV coat protein, gp90 DUF4191 PF13829.6 EWC48007.1 - 0.088 12.1 1.0 0.33 10.3 1.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) BofA PF07441.11 EWC48007.1 - 7.4 6.9 17.8 0.46 10.7 8.1 3.8 2 1 1 3 3 3 0 SigmaK-factor processing regulatory protein BofA DUF3972 PF13118.6 EWC48008.1 - 0.18 12.3 12.8 0.11 12.9 8.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) Bacillus_HBL PF05791.11 EWC48008.1 - 0.55 10.0 20.3 6.5 6.5 0.1 3.4 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) TACC_C PF05010.14 EWC48008.1 - 0.69 9.7 33.3 0.12 12.1 19.2 3.0 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF3552 PF12072.8 EWC48008.1 - 2.2 7.7 55.8 0.057 12.8 11.6 4.4 1 1 3 4 4 4 0 Domain of unknown function (DUF3552) HMMR_N PF15905.5 EWC48008.1 - 5.7 6.3 45.2 0.63 9.5 9.0 3.2 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Sugar_tr PF00083.24 EWC48009.1 - 4.1e-15 55.6 9.3 4.5e-15 55.5 9.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter DMT_YdcZ PF04657.13 EWC48009.1 - 0.14 12.5 3.1 0.16 12.2 3.1 1.2 1 0 0 1 1 1 0 Putative inner membrane exporter, YdcZ Peptidase_M10 PF00413.24 EWC48010.1 - 9.6e-18 64.5 0.0 1.1e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.6 EWC48010.1 - 0.013 15.2 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 EWC48010.1 - 0.02 13.5 0.0 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M54 PF07998.11 EWC48010.1 - 0.028 14.4 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 EWC48010.1 - 0.031 13.2 0.3 0.046 12.7 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 Astacin PF01400.24 EWC48010.1 - 0.053 13.1 1.1 9.7 5.7 1.2 2.3 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M57 PF12388.8 EWC48010.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 EWC48010.1 - 0.24 10.6 0.7 0.38 9.9 0.7 1.2 1 0 0 1 1 1 0 Met-zincin Sugar_tr PF00083.24 EWC48011.1 - 2.3e-22 79.5 24.4 1.9e-20 73.2 24.4 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter Baculo_p74 PF04583.12 EWC48011.1 - 0.1 12.1 0.8 0.18 11.2 0.8 1.3 1 0 0 1 1 1 0 Baculoviridae p74 conserved region DUF1996 PF09362.10 EWC48013.1 - 2.4e-69 233.9 1.3 3.2e-69 233.5 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Carb_anhydrase PF00194.21 EWC48014.1 - 1.3e-37 129.8 0.0 1.7e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase ADH_N PF08240.12 EWC48016.1 - 8.2e-27 93.3 3.0 1.3e-26 92.6 3.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC48016.1 - 1.8e-18 66.7 1.6 5.6e-18 65.2 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EWC48016.1 - 0.00013 21.3 0.2 0.00021 20.7 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EWC48016.1 - 0.00036 19.9 0.5 0.00061 19.2 0.5 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EWC48016.1 - 0.0013 18.6 0.3 0.11 12.3 0.6 2.2 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 EWC48016.1 - 0.0013 19.8 0.0 0.0031 18.6 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.18 EWC48016.1 - 0.0021 18.3 0.2 0.0035 17.6 0.2 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_10 PF13460.6 EWC48016.1 - 0.013 15.4 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding NAD_binding_2 PF03446.15 EWC48016.1 - 0.015 15.4 0.1 0.03 14.5 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EWC48016.1 - 0.068 12.8 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 EWC48016.1 - 0.11 11.8 2.6 0.24 10.7 2.6 1.5 1 0 0 1 1 1 0 ThiF family GFA PF04828.14 EWC48017.1 - 2.2e-23 82.4 2.3 2.2e-23 82.4 2.3 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme RTC PF01137.21 EWC48019.1 - 1.9e-30 105.7 0.0 2.5e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EWC48019.1 - 2.8e-29 101.6 0.0 5.8e-29 100.6 0.0 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain VSP PF03302.13 EWC48020.1 - 0.00069 18.6 0.1 0.0011 17.9 0.1 1.3 1 0 0 1 1 1 1 Giardia variant-specific surface protein Podoplanin PF05808.11 EWC48020.1 - 0.00096 19.3 1.1 0.0021 18.2 1.1 1.5 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.10 EWC48020.1 - 0.068 12.6 6.5 0.16 11.4 6.5 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Rubella_E2 PF05749.11 EWC48021.1 - 0.1 12.0 1.3 0.14 11.6 1.3 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 zf-C2HC5 PF06221.13 EWC48022.1 - 5.2e-20 71.2 6.8 9.4e-20 70.4 6.8 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type CDC24_OB3 PF17244.2 EWC48022.1 - 0.072 12.8 0.5 0.12 12.1 0.5 1.3 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 CsoSCA PF08936.10 EWC48022.1 - 0.19 10.4 0.0 0.27 9.8 0.0 1.1 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase zf-FCS PF06467.14 EWC48022.1 - 0.56 10.2 2.3 1.1 9.2 0.0 2.3 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif F-box PF00646.33 EWC48023.1 - 0.00039 20.2 0.0 0.00083 19.2 0.0 1.5 1 0 0 1 1 1 1 F-box domain DUF3455 PF11937.8 EWC48024.1 - 5.2e-33 114.7 0.2 7.1e-33 114.2 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Sulfate_transp PF00916.20 EWC48027.1 - 2.6e-113 378.7 19.9 3.4e-113 378.2 19.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EWC48027.1 - 1.2e-06 28.1 0.0 2.4e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EWC48027.1 - 0.0001 22.7 3.6 0.0001 22.7 3.6 3.6 3 1 1 4 4 4 1 Molybdate transporter of MFS superfamily Ribonucleas_3_3 PF14622.6 EWC48028.1 - 4.5e-06 26.8 0.0 8e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EWC48028.1 - 2.1e-05 25.1 0.0 0.00013 22.5 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 EWC48028.1 - 0.00011 22.9 0.0 0.00018 22.2 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EWC48028.1 - 0.0037 17.5 0.3 0.018 15.3 0.3 2.0 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Pentapeptide_2 PF01469.18 EWC48029.1 - 0.005 16.7 44.5 0.01 15.7 20.1 2.5 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) APH PF01636.23 EWC48030.1 - 1.8e-44 152.5 0.0 2.6e-44 152.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EWC48030.1 - 4.4e-07 29.7 0.0 7.4e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EWC48030.1 - 3.2e-06 26.7 0.0 5.6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 EWC48030.1 - 0.00013 21.6 0.0 0.034 13.7 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Pkinase PF00069.25 EWC48030.1 - 0.0027 17.1 0.0 1.8 7.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain DUF1679 PF07914.11 EWC48030.1 - 0.13 11.1 0.0 0.25 10.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Ank_4 PF13637.6 EWC48031.1 - 0.00048 20.6 0.0 0.91 10.2 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EWC48031.1 - 0.00056 20.4 0.0 0.015 15.9 0.0 3.0 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Sec63 PF02889.16 EWC48033.1 - 1.5e-153 509.3 0.0 6.4e-89 297.5 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EWC48033.1 - 6.4e-52 175.9 0.3 4.3e-28 98.2 0.1 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EWC48033.1 - 1.6e-36 124.9 0.5 4.2e-36 123.5 0.1 2.0 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 EWC48033.1 - 3.7e-24 85.6 0.0 5.3e-13 49.3 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EWC48033.1 - 1.9e-09 37.8 0.0 2.3e-07 31.2 0.0 3.5 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EWC48033.1 - 4.4e-07 30.3 0.2 0.011 16.1 0.1 3.3 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EWC48033.1 - 8.5e-05 22.4 0.0 0.4 10.4 0.0 3.6 3 0 0 3 3 3 2 AAA domain T2SSE PF00437.20 EWC48033.1 - 0.00044 19.4 0.0 0.4 9.7 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein PhoH PF02562.16 EWC48033.1 - 0.00053 19.5 0.0 0.21 11.0 0.0 3.3 3 0 0 3 3 3 1 PhoH-like protein AAA_19 PF13245.6 EWC48033.1 - 0.0012 19.2 0.0 0.43 10.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 EWC48033.1 - 0.033 13.7 0.0 0.77 9.2 0.0 2.6 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 EWC48033.1 - 0.082 12.4 0.3 15 5.1 0.0 2.9 3 0 0 3 3 3 0 P-loop containing dynein motor region Tub_N PF16322.5 EWC48033.1 - 4.7 7.6 9.9 3.8 7.9 0.3 2.5 2 0 0 2 2 2 0 Tubby N-terminal Gin PF10764.9 EWC48035.1 - 0.07 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin Peptidase_S8 PF00082.22 EWC48036.1 - 1.3e-25 90.3 3.9 1.7e-25 89.9 3.9 1.3 1 0 0 1 1 1 1 Subtilase family PWWP PF00855.17 EWC48037.1 - 2.9e-12 46.8 0.0 2.9e-12 46.8 0.0 3.6 3 1 0 3 3 3 1 PWWP domain CPSase_L_D2 PF02786.17 EWC48038.1 - 9.3e-111 368.4 0.1 2.1e-84 282.2 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EWC48038.1 - 4.1e-40 136.9 0.0 9.4e-40 135.8 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EWC48038.1 - 9.8e-19 67.6 0.0 4.8e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EWC48038.1 - 1.7e-15 57.1 0.2 1.8e-06 27.6 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EWC48038.1 - 1e-11 44.7 0.0 0.00018 21.2 0.0 2.7 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 EWC48038.1 - 5.5e-05 22.8 0.8 0.3 10.7 0.0 3.3 3 0 0 3 3 3 2 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 EWC48038.1 - 6e-05 22.6 0.1 0.0084 15.6 0.1 2.7 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 EWC48038.1 - 9.8e-05 22.2 0.1 0.38 10.5 0.0 2.6 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain MGS PF02142.22 EWC48038.1 - 0.048 13.9 0.0 0.16 12.2 0.0 2.0 1 0 0 1 1 1 0 MGS-like domain CAP_GLY PF01302.25 EWC48040.1 - 3.5e-18 65.4 1.4 6.9e-18 64.4 1.4 1.5 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EWC48040.1 - 4.9e-07 29.5 10.4 0.00048 19.9 1.3 2.3 2 0 0 2 2 2 2 CLIP1 zinc knuckle Fez1 PF06818.15 EWC48040.1 - 0.0035 17.8 14.3 0.0035 17.8 14.3 2.6 2 1 0 2 2 2 1 Fez1 AAA_13 PF13166.6 EWC48040.1 - 0.0038 15.9 10.4 0.0038 15.9 10.4 2.8 1 1 2 3 3 3 1 AAA domain CENP-F_leu_zip PF10473.9 EWC48040.1 - 0.0093 16.0 7.3 0.0093 16.0 7.3 4.2 4 0 0 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4988 PF16378.5 EWC48040.1 - 0.038 13.6 1.4 0.13 11.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function BBP1_C PF15272.6 EWC48040.1 - 2.2 8.1 27.2 2.6 7.9 1.0 4.1 4 0 0 4 4 4 0 Spindle pole body component BBP1, C-terminal LPP PF04728.13 EWC48040.1 - 2.3 8.6 9.8 35 4.9 0.0 4.6 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Sel1 PF08238.12 EWC48041.1 - 9.3e-15 54.7 10.0 7e-05 23.4 0.3 3.8 3 0 0 3 3 3 3 Sel1 repeat Gal-bind_lectin PF00337.22 EWC48042.1 - 0.00084 18.9 0.0 0.0015 18.1 0.0 1.4 1 1 0 1 1 1 1 Galactoside-binding lectin ADH_N PF08240.12 EWC48043.1 - 2.8e-05 24.0 0.7 5.6e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC48043.1 - 0.00027 20.9 0.1 0.00054 19.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SF3b1 PF08920.10 EWC48044.1 - 4.9e-31 107.7 5.7 4.9e-31 107.7 5.7 2.7 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_EZ PF13513.6 EWC48044.1 - 1.2e-11 44.9 0.9 0.067 13.7 0.0 7.2 7 1 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.6 EWC48044.1 - 1.7e-09 37.9 7.6 0.22 12.0 0.0 8.1 7 1 3 10 10 10 4 HEAT repeats Dopey_N PF04118.14 EWC48044.1 - 9.6e-06 24.9 0.3 0.84 8.7 0.0 4.9 4 1 0 5 5 5 1 Dopey, N-terminal HEAT PF02985.22 EWC48044.1 - 1.3e-05 25.0 10.3 1.8 9.0 0.1 8.7 10 0 0 10 10 8 1 HEAT repeat DUF3385 PF11865.8 EWC48044.1 - 6.1e-05 23.0 3.7 0.014 15.3 0.0 5.3 6 1 1 7 7 7 1 Domain of unknown function (DUF3385) NUC173 PF08161.12 EWC48044.1 - 0.00015 21.5 0.5 1.9 8.1 0.0 4.5 3 1 2 5 5 5 1 NUC173 domain Vac14_Fab1_bd PF12755.7 EWC48044.1 - 0.00028 21.4 0.6 3.9 8.1 0.0 5.3 6 0 0 6 6 5 1 Vacuolar 14 Fab1-binding region UME PF08064.13 EWC48044.1 - 0.0062 16.4 0.0 13 5.8 0.0 4.9 5 1 1 6 6 6 1 UME (NUC010) domain UNC45-central PF11701.8 EWC48044.1 - 0.02 14.8 0.0 0.054 13.5 0.0 1.7 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EWC48044.1 - 0.025 14.2 0.1 2.4 7.6 0.0 3.3 3 0 0 3 3 3 0 CLASP N terminal DRIM PF07539.12 EWC48044.1 - 0.06 11.7 0.5 4.5 5.5 0.0 3.7 2 1 1 3 3 3 0 Down-regulated in metastasis DNA_pol_A_exo1 PF01612.20 EWC48045.1 - 9.5e-14 51.5 0.0 1.3e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease WLM PF08325.10 EWC48046.1 - 4.2e-38 131.3 0.0 1.2e-37 129.9 0.0 1.8 2 1 1 3 3 3 1 WLM domain DUF45 PF01863.17 EWC48046.1 - 0.015 15.4 0.5 0.026 14.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 DZR PF12773.7 EWC48046.1 - 0.045 13.8 4.1 1.6 8.8 0.3 2.3 2 0 0 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 EWC48046.1 - 0.37 11.2 2.8 2.1 8.7 0.1 2.4 2 0 0 2 2 2 0 C1 domain Vps36-NZF-N PF16988.5 EWC48046.1 - 0.79 9.2 8.7 1.2 8.5 0.3 3.1 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF2318 PF10080.9 EWC48046.1 - 4.2 7.6 4.8 1 9.5 0.1 2.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2318) Sec66 PF09802.9 EWC48048.1 - 2.3e-65 219.5 0.4 2.8e-65 219.3 0.4 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 PEP-utilisers_N PF05524.13 EWC48048.1 - 0.00029 21.0 2.0 0.00052 20.2 2.0 1.5 1 0 0 1 1 1 1 PEP-utilising enzyme, N-terminal NuiA PF07924.11 EWC48048.1 - 0.15 12.4 0.6 0.25 11.7 0.6 1.3 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein PP2C_2 PF13672.6 EWC48049.1 - 1.9e-09 37.5 0.0 3.2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EWC48049.1 - 8.4e-06 25.8 0.2 3.8e-05 23.7 0.1 2.2 3 1 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EWC48049.1 - 3e-05 23.8 0.4 0.11 12.1 0.1 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C CDP-OH_P_transf PF01066.21 EWC48050.1 - 0.047 14.5 0.4 0.29 11.9 0.4 2.2 1 1 0 1 1 1 0 CDP-alcohol phosphatidyltransferase DUF4231 PF14015.6 EWC48050.1 - 0.47 10.9 6.0 0.31 11.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4187 PF13821.6 EWC48051.1 - 2.9e-21 75.0 2.8 6.4e-21 73.9 2.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EWC48051.1 - 8.8e-07 28.7 0.0 1.8e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 G-patch domain NUDE_C PF04880.13 EWC48051.1 - 2.1 8.8 14.9 0.034 14.6 6.0 2.4 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region RL10P_insert PF17777.1 EWC48052.1 - 1e-21 76.7 0.1 2.4e-21 75.5 0.0 1.6 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EWC48052.1 - 4.9e-21 74.7 0.6 2.3e-20 72.6 0.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 EWC48052.1 - 3e-18 66.2 4.2 3e-18 66.2 4.2 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein VEG PF06257.11 EWC48052.1 - 0.14 12.3 0.1 0.29 11.2 0.1 1.5 1 0 0 1 1 1 0 Biofilm formation stimulator VEG FMN_red PF03358.15 EWC48053.1 - 7.3e-10 38.8 0.0 1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EWC48053.1 - 2.8e-09 37.0 0.0 3.4e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EWC48053.1 - 0.0049 17.1 0.1 0.16 12.2 0.1 2.2 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EWC48053.1 - 0.035 14.3 0.1 0.093 13.0 0.0 1.8 2 0 0 2 2 2 0 Flavodoxin domain Smoothelin PF12510.8 EWC48053.1 - 0.071 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein DUF4349 PF14257.6 EWC48054.1 - 0.14 11.6 0.7 0.4 10.1 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Colicin_V PF02674.16 EWC48054.1 - 7.9 6.4 14.6 28 4.7 12.7 2.7 1 1 1 2 2 2 0 Colicin V production protein adh_short PF00106.25 EWC48055.1 - 3.5e-22 78.8 0.0 1.1e-16 60.9 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48055.1 - 6.6e-12 45.5 0.1 1.5e-09 37.7 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC48055.1 - 3.1e-05 24.0 0.0 5.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EWC48055.1 - 0.019 15.1 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NPL4 PF05021.15 EWC48056.1 - 1.1e-129 432.2 0.0 1.4e-129 431.9 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EWC48056.1 - 2e-70 235.6 0.1 2.9e-70 235.1 0.1 1.2 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EWC48056.1 - 8.3e-06 26.2 0.0 2.5e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 dCMP_cyt_deam_1 PF00383.23 EWC48057.1 - 2e-24 85.4 0.0 2.7e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EWC48057.1 - 6.3e-19 68.1 0.0 8.1e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EWC48057.1 - 7.7e-05 22.8 0.4 0.072 13.2 0.1 2.7 1 1 2 3 3 3 2 Bd3614-like deaminase SNAD4 PF18750.1 EWC48057.1 - 0.00087 19.4 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 EWC48057.1 - 0.017 15.2 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 APOBEC2 APOBEC_N PF08210.11 EWC48057.1 - 0.021 14.7 0.0 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain NAD1 PF18778.1 EWC48057.1 - 0.028 14.5 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC4_like PF18774.1 EWC48057.1 - 0.031 14.2 0.0 0.049 13.6 0.0 1.3 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase XOO_2897-deam PF14440.6 EWC48057.1 - 0.061 13.4 0.0 0.19 11.8 0.0 1.7 2 0 0 2 2 2 0 Xanthomonas XOO_2897-like deaminase Inv-AAD PF18785.1 EWC48057.1 - 0.1 12.5 0.2 0.36 10.7 0.2 1.8 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase APOBEC3 PF18771.1 EWC48057.1 - 0.19 11.8 0.0 0.3 11.2 0.0 1.2 1 0 0 1 1 1 0 APOBEC3 NAD2 PF18782.1 EWC48057.1 - 0.21 11.7 0.0 0.3 11.2 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 BAH PF01426.18 EWC48058.1 - 2.5e-22 79.0 0.0 6.9e-22 77.6 0.0 1.8 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H_2 PF13832.6 EWC48058.1 - 1.3e-18 67.2 3.8 1.3e-18 67.2 3.8 3.8 4 1 0 4 4 4 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EWC48058.1 - 9e-14 51.5 6.0 9e-14 51.5 6.0 4.2 4 0 0 4 4 4 2 PHD-like zinc-binding domain PHD PF00628.29 EWC48058.1 - 1.6e-10 40.7 55.1 1.1e-06 28.4 9.4 6.5 6 1 1 7 7 7 3 PHD-finger PHD_2 PF13831.6 EWC48058.1 - 7.2e-08 31.9 6.0 7.2e-08 31.9 6.0 5.5 7 0 0 7 7 7 2 PHD-finger GATA PF00320.27 EWC48058.1 - 0.00055 19.5 8.4 0.12 12.0 0.4 4.2 3 0 0 3 3 3 2 GATA zinc finger Myb_DNA-binding PF00249.31 EWC48058.1 - 0.0043 17.2 0.1 0.0098 16.1 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Miga PF10265.9 EWC48058.1 - 0.071 12.1 0.0 0.071 12.1 0.0 2.1 2 0 0 2 2 2 0 Mitoguardin Minor_tail_Z PF06763.11 EWC48058.1 - 1.5 8.6 4.5 7.3 6.3 0.2 3.1 1 1 2 3 3 3 0 Prophage minor tail protein Z (GPZ) Pkinase PF00069.25 EWC48059.1 - 4.8e-32 111.4 0.0 1.3e-19 70.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48059.1 - 8.1e-12 45.0 0.0 1.3e-10 41.0 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EWC48059.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Methyltransf_25 PF13649.6 EWC48060.1 - 3.6e-10 40.4 0.1 5.9e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC48060.1 - 2.1e-09 37.9 0.0 3.3e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC48060.1 - 6.7e-07 30.0 0.0 9.8e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC48060.1 - 6e-05 22.9 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC48060.1 - 0.00013 21.8 0.0 0.00016 21.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EWC48060.1 - 0.00061 18.9 0.0 0.0008 18.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.19 EWC48060.1 - 0.0033 17.2 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EWC48060.1 - 0.0088 15.6 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EWC48060.1 - 0.014 15.4 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 EWC48060.1 - 0.057 12.5 0.0 0.11 11.6 0.0 1.4 2 0 0 2 2 2 0 DREV methyltransferase DnaJ_C PF01556.18 EWC48061.1 - 9e-38 129.7 0.2 1.2e-37 129.3 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EWC48061.1 - 5e-23 81.0 2.1 7.9e-23 80.4 2.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EWC48061.1 - 1.6e-14 54.0 20.8 2.8e-14 53.2 20.8 1.4 1 0 0 1 1 1 1 DnaJ central domain zinc-ribbons_6 PF07191.12 EWC48061.1 - 7.4 6.6 8.6 5.6 7.0 2.1 2.2 1 1 1 2 2 2 0 zinc-ribbons TAP_C PF03943.13 EWC48062.1 - 6.7e-16 57.7 0.4 1.5e-15 56.6 0.4 1.5 1 0 0 1 1 1 1 TAP C-terminal domain LRR_9 PF14580.6 EWC48062.1 - 0.00012 21.6 0.1 0.00022 20.8 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat NTF2 PF02136.20 EWC48062.1 - 0.0003 21.3 0.0 0.00061 20.3 0.0 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.7 EWC48062.1 - 0.00042 20.7 4.1 0.00058 20.2 0.8 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EWC48062.1 - 0.0098 15.6 0.9 0.033 14.0 0.8 2.0 1 1 0 1 1 1 1 Leucine rich repeat RRM_9 PF18444.1 EWC48062.1 - 0.04 13.8 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif DUF2514 PF10721.9 EWC48062.1 - 0.047 13.7 0.8 0.086 12.9 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) UBA_4 PF14555.6 EWC48062.1 - 0.053 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain MutS_V PF00488.21 EWC48063.1 - 3.5e-68 229.3 0.1 5.1e-67 225.6 0.0 2.6 3 0 0 3 3 3 1 MutS domain V MutS_III PF05192.18 EWC48063.1 - 1.3e-39 136.4 0.5 6.4e-39 134.2 0.5 2.0 1 1 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EWC48063.1 - 2.8e-17 63.0 0.0 8.7e-17 61.4 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EWC48063.1 - 4.5e-09 36.7 0.0 2e-08 34.6 0.0 2.0 1 1 0 1 1 1 1 MutS domain II ABC_tran PF00005.27 EWC48063.1 - 0.029 14.9 0.0 6 7.4 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.6 EWC48063.1 - 0.03 14.4 0.0 0.18 11.8 0.0 2.3 3 0 0 3 3 3 0 AAA domain eIF3_subunit PF08597.10 EWC48063.1 - 0.031 14.2 6.3 0.057 13.3 6.3 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit AAA_27 PF13514.6 EWC48063.1 - 0.094 12.3 0.5 0.49 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF2828 PF11443.8 EWC48063.1 - 0.12 10.5 0.4 0.17 10.0 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) AAA_23 PF13476.6 EWC48063.1 - 1.5 9.3 0.0 1.5 9.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain Dicty_REP PF05086.12 EWC48064.1 - 2.1 6.2 7.0 2.8 5.8 7.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein EB PF01683.18 EWC48065.1 - 3.6e-08 33.6 49.8 0.091 13.1 0.1 6.2 5 1 1 6 6 6 5 EB module MTBP_C PF14920.6 EWC48065.1 - 0.88 9.3 9.9 8.4 6.1 0.3 3.1 3 0 0 3 3 3 0 MDM2-binding zf-CCHH PF10283.9 EWC48065.1 - 1.8 8.6 7.7 32 4.6 0.2 3.5 3 0 0 3 3 3 0 PBZ domain URO-D PF01208.17 EWC48067.1 - 3.7e-133 444.0 0.0 4.2e-133 443.8 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Peptidase_S9 PF00326.21 EWC48068.1 - 1.2e-54 185.0 0.1 2e-54 184.3 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EWC48068.1 - 0.0004 20.1 2.0 0.13 11.9 0.0 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold PD40 PF07676.12 EWC48068.1 - 0.0044 16.9 0.9 0.36 10.8 0.0 2.9 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DUF2920 PF11144.8 EWC48068.1 - 0.03 13.5 0.0 1.7 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) AXE1 PF05448.12 EWC48068.1 - 0.034 12.8 0.2 0.14 10.8 0.2 1.9 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Peptidase_S9_N PF02897.15 EWC48068.1 - 0.091 11.5 1.4 0.68 8.7 1.7 2.1 1 1 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain GDP_Man_Dehyd PF16363.5 EWC48070.1 - 2.7e-69 234.1 0.0 3.1e-69 233.9 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EWC48070.1 - 2.6e-56 190.8 0.0 3.3e-56 190.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EWC48070.1 - 2.5e-23 82.7 0.0 4.6e-22 78.5 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EWC48070.1 - 8e-19 67.7 0.0 1.1e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EWC48070.1 - 1.4e-18 67.0 0.1 2.6e-17 62.9 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EWC48070.1 - 1e-15 57.6 0.0 1.4e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EWC48070.1 - 2.5e-06 27.5 0.0 3.4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EWC48070.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 KR domain SesA PF17107.5 EWC48071.1 - 3.8e-34 117.5 1.4 3.8e-34 117.5 1.4 2.4 3 0 0 3 3 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases WD40 PF00400.32 EWC48071.1 - 1.6e-25 88.8 25.8 8.2e-11 42.3 0.1 8.0 8 0 0 8 8 7 4 WD domain, G-beta repeat NACHT PF05729.12 EWC48071.1 - 1.1e-22 80.7 0.0 2.3e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EWC48071.1 - 6e-11 42.5 1.8 0.0011 19.2 0.0 5.5 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EWC48071.1 - 1.3e-07 31.0 2.8 0.085 11.8 0.0 4.4 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Helo_like_N PF17111.5 EWC48071.1 - 0.00042 19.8 0.0 0.0012 18.3 0.0 1.7 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins Nucleoporin_N PF08801.11 EWC48071.1 - 0.0058 15.4 7.4 1.3 7.7 0.1 4.1 2 1 2 4 4 4 2 Nup133 N terminal like Nbas_N PF15492.6 EWC48071.1 - 0.015 14.6 4.7 17 4.6 0.0 5.2 3 2 3 6 6 6 0 Neuroblastoma-amplified sequence, N terminal CDtoxinA PF03498.14 EWC48071.1 - 0.02 14.5 0.8 3.1 7.4 0.0 3.2 1 1 2 3 3 3 0 Cytolethal distending toxin A/C domain AAA_11 PF13086.6 EWC48071.1 - 0.036 13.8 0.1 2 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain PD40 PF07676.12 EWC48071.1 - 0.041 13.8 1.8 14 5.8 0.3 3.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat MTTB PF06253.11 EWC48071.1 - 0.18 9.8 0.0 0.26 9.2 0.0 1.1 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) zf_CCCH_4 PF18345.1 EWC48072.1 - 1.9e-17 62.7 37.9 8.3e-07 28.9 2.1 5.5 5 0 0 5 5 5 5 Zinc finger domain zf-CCCH PF00642.24 EWC48072.1 - 2e-17 62.6 37.5 2.4e-05 24.1 0.5 5.6 5 1 1 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EWC48072.1 - 1.4e-10 41.9 26.2 0.00055 20.6 0.6 5.1 1 1 4 5 5 5 5 Torus domain zf-CCCH_3 PF15663.5 EWC48072.1 - 2e-05 24.7 20.6 4.8e-05 23.5 2.6 3.4 1 1 2 3 3 3 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 EWC48072.1 - 3.7e-05 23.4 0.5 3.7e-05 23.4 0.5 5.6 5 1 0 5 5 5 2 CCCH-type zinc finger LUC7 PF03194.15 EWC48072.1 - 2.7 7.6 6.5 10 5.7 0.5 3.0 3 0 0 3 3 3 0 LUC7 N_terminus Nab2p_Zf1 PF18260.1 EWC48072.1 - 8.6 6.4 17.5 0.89 9.5 2.4 3.7 3 0 0 3 3 3 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 Vps53_N PF04100.12 EWC48073.1 - 5.7e-104 348.1 0.9 1.4e-103 346.9 0.2 1.8 2 0 0 2 2 2 1 Vps53-like, N-terminal DUF2451 PF10474.9 EWC48073.1 - 1.7e-08 34.5 0.1 5.1e-08 33.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) RINT1_TIP1 PF04437.13 EWC48073.1 - 4.2e-05 22.6 2.4 0.00024 20.1 0.1 2.6 3 0 0 3 3 3 1 RINT-1 / TIP-1 family Vps54_N PF10475.9 EWC48073.1 - 9.8e-05 21.8 3.3 0.00025 20.4 3.3 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex VPS53_C PF16854.5 EWC48073.1 - 0.00086 19.2 0.0 0.0029 17.5 0.0 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 53 C-terminus Zw10 PF06248.13 EWC48073.1 - 0.0044 15.6 3.8 0.0086 14.7 3.8 1.4 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 DUF1024 PF06260.12 EWC48073.1 - 0.021 15.1 0.1 0.11 12.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1024) Tctex-1 PF03645.13 EWC48073.1 - 0.036 14.3 0.2 16 5.8 0.1 2.8 2 0 0 2 2 2 0 Tctex-1 family COG2 PF06148.11 EWC48073.1 - 0.088 12.9 0.8 0.38 10.8 0.2 2.4 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 PurL_C PF16904.5 EWC48073.1 - 0.15 12.4 0.1 0.57 10.5 0.1 2.0 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine synthase II C-terminus E2R135 PF11570.8 EWC48073.1 - 0.17 12.2 0.4 0.38 11.0 0.4 1.5 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 Mg_chelatase_C PF13335.6 EWC48073.1 - 0.36 11.5 3.0 0.75 10.5 1.1 2.4 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal LCE6A PF15858.5 EWC48074.1 - 0.0099 16.6 0.6 0.025 15.3 0.1 2.0 2 0 0 2 2 2 1 Late cornified envelope protein 6A family DUF632 PF04782.12 EWC48075.1 - 0.0048 16.3 3.3 0.044 13.1 0.7 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF632) Vac_Fusion PF02346.16 EWC48075.1 - 0.016 14.8 2.3 0.031 13.9 0.1 2.4 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 COG5 PF10392.9 EWC48075.1 - 0.11 12.7 5.0 1.1 9.4 0.6 2.5 1 1 1 2 2 2 0 Golgi transport complex subunit 5 GAS PF13851.6 EWC48075.1 - 0.24 10.7 7.4 0.022 14.1 2.8 1.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EWC48075.1 - 0.28 11.2 4.2 1.1 9.3 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EWC48075.1 - 1.1 9.4 6.4 0.29 11.3 2.3 2.1 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.9 EWC48075.1 - 1.5 8.8 0.0 1.5 8.8 0.0 2.8 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DEAD PF00270.29 EWC48077.1 - 1.4e-45 155.2 1.7 2.6e-45 154.3 1.7 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC48077.1 - 1.1e-32 112.6 0.4 1.8e-31 108.7 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC48077.1 - 1.7e-07 31.4 0.0 2.9e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EWC48077.1 - 2.8e-05 23.9 0.3 5.6e-05 23.0 0.3 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EWC48077.1 - 0.00084 19.7 3.0 0.0026 18.1 3.0 1.9 1 1 1 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 EWC48077.1 - 0.0072 16.3 0.3 0.034 14.1 0.3 2.0 1 1 0 1 1 1 1 Flavivirus DEAD domain AAA_22 PF13401.6 EWC48077.1 - 0.014 15.6 1.4 0.079 13.2 1.4 2.2 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 EWC48077.1 - 0.015 15.2 0.1 0.029 14.2 0.1 1.6 2 0 0 2 2 2 0 Helicase PhoH PF02562.16 EWC48077.1 - 0.057 12.9 1.9 0.21 11.0 1.9 2.0 1 1 0 1 1 1 0 PhoH-like protein CMS1 PF14617.6 EWC48077.1 - 0.058 12.7 0.7 0.18 11.1 0.0 2.1 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit fragilysinNterm PF16376.5 EWC48077.1 - 0.067 12.9 0.0 0.23 11.2 0.0 1.9 1 0 0 1 1 1 0 N-terminal domain of fragilysin MatE PF01554.18 EWC48078.1 - 2.5e-05 24.0 7.8 2.5e-05 24.0 7.8 3.5 4 0 0 4 4 4 3 MatE Polysacc_synt_C PF14667.6 EWC48078.1 - 0.0014 18.8 4.9 0.0014 18.8 4.9 3.7 2 2 0 2 2 2 1 Polysaccharide biosynthesis C-terminal domain Ilm1 PF10311.9 EWC48078.1 - 0.019 14.6 0.6 0.019 14.6 0.6 2.1 2 0 0 2 2 2 0 Increased loss of mitochondrial DNA protein 1 WD40 PF00400.32 EWC48079.1 - 3.1e-19 68.9 14.7 0.0007 20.4 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48079.1 - 1e-07 32.1 0.1 0.026 14.8 0.0 4.7 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC48079.1 - 0.0031 16.2 4.0 0.59 8.7 0.5 3.1 2 1 0 3 3 3 2 Nucleoporin Nup120/160 SR-25 PF10500.9 EWC48079.1 - 0.0071 16.0 1.8 0.0071 16.0 1.8 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Nucleoporin_N PF08801.11 EWC48079.1 - 0.026 13.3 0.1 2.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Nup133 N terminal like SRP72 PF08492.12 EWC48079.1 - 0.081 13.4 11.7 4.5 7.8 9.2 2.5 2 0 0 2 2 2 0 SRP72 RNA-binding domain SART-1 PF03343.13 EWC48079.1 - 0.37 9.3 20.1 0.14 10.7 16.9 1.7 2 0 0 2 2 2 0 SART-1 family DUF1754 PF08555.10 EWC48079.1 - 5.9 7.8 22.5 0.74 10.7 9.1 2.9 3 0 0 3 3 3 0 Eukaryotic family of unknown function (DUF1754) Protocadherin PF08374.11 EWC48079.1 - 6.1 6.8 7.3 23 4.9 0.2 2.3 2 0 0 2 2 2 0 Protocadherin RNA_polI_A34 PF08208.11 EWC48079.1 - 9.6 6.2 19.2 15 5.6 13.5 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1776 PF08643.10 EWC48080.1 - 5.8e-78 262.2 0.0 7.1e-78 262.0 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 EWC48080.1 - 0.0011 18.4 0.0 0.0062 16.0 0.0 2.2 2 1 0 2 2 2 1 short chain dehydrogenase Gram_pos_anchor PF00746.21 EWC48080.1 - 0.086 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF5129 PF17173.4 EWC48080.1 - 0.29 10.2 1.8 0.61 9.2 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) CHAT PF12770.7 EWC48082.1 - 7.7e-34 117.4 0.1 1.5e-33 116.5 0.1 1.4 1 0 0 1 1 1 1 CHAT domain MetOD2 PF18548.1 EWC48082.1 - 0.06 13.5 0.0 2.8 8.1 0.0 2.9 2 0 0 2 2 2 0 Metanogen output domain 2 wnt PF00110.19 EWC48082.1 - 0.15 11.6 0.1 64 3.0 0.0 3.3 3 1 1 4 4 4 0 wnt family TPR_8 PF13181.6 EWC48082.1 - 1.3 9.4 10.2 51 4.4 0.0 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat PCI PF01399.27 EWC48083.1 - 2.8e-15 56.7 0.8 8.1e-15 55.2 0.0 2.1 2 1 0 2 2 2 1 PCI domain CPSase_L_D2 PF02786.17 EWC48084.1 - 3.3e-71 239.1 0.0 6e-71 238.3 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EWC48084.1 - 1.3e-38 131.9 0.0 2.7e-38 130.9 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EWC48084.1 - 4.9e-37 126.3 0.0 1.2e-36 125.1 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EWC48084.1 - 7.5e-15 54.5 0.1 1.8e-14 53.3 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EWC48084.1 - 1e-08 35.0 0.0 3.3e-08 33.3 0.0 1.8 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 EWC48084.1 - 0.00047 19.9 0.0 0.0023 17.7 0.0 2.1 1 1 1 2 2 2 1 Biotin-lipoyl like GARS_A PF01071.19 EWC48084.1 - 0.0071 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 EWC48084.1 - 0.0077 15.8 0.0 0.023 14.3 0.0 1.7 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EWC48084.1 - 0.013 15.6 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain HlyD_3 PF13437.6 EWC48084.1 - 0.079 13.7 0.1 16 6.2 0.0 3.2 3 0 0 3 3 3 0 HlyD family secretion protein GCV_H PF01597.19 EWC48084.1 - 0.081 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein MARVEL PF01284.23 EWC48086.1 - 3.6e-08 33.6 11.6 9.3e-08 32.2 5.6 2.2 1 1 1 2 2 2 1 Membrane-associating domain DUF981 PF06168.11 EWC48086.1 - 0.07 13.0 5.3 0.11 12.4 5.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF981) MARVEL PF01284.23 EWC48087.1 - 2.8e-13 50.1 11.6 3.9e-13 49.7 11.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain Solute_trans_a PF03619.16 EWC48087.1 - 0.032 13.7 2.7 0.04 13.4 1.7 1.6 2 0 0 2 2 2 0 Organic solute transporter Ostalpha MlaE PF02405.16 EWC48087.1 - 2.1 8.0 8.9 1.2 8.7 5.9 2.1 2 1 0 2 2 2 0 Permease MlaE Bax1-I PF01027.20 EWC48088.1 - 7.7e-57 192.5 26.7 8.8e-57 192.3 26.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 EWC48088.1 - 1.4e-13 50.9 6.6 1.5e-13 50.8 6.6 1.1 1 0 0 1 1 1 1 Bax inhibitor 1 like SirB PF04247.12 EWC48088.1 - 0.013 15.6 3.8 0.013 15.6 3.8 2.2 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB DUF4229 PF14012.6 EWC48088.1 - 4 7.6 10.6 0.71 10.0 1.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF4229) COesterase PF00135.28 EWC48090.1 - 1.1e-88 298.4 0.0 1.3e-88 298.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EWC48090.1 - 9.7e-10 38.7 0.0 1.3e-08 35.0 0.0 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EWC48090.1 - 0.024 14.1 0.1 0.043 13.3 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family SSXRD PF09514.10 EWC48090.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 SSXRD motif SH3_9 PF14604.6 EWC48091.1 - 5e-13 48.7 0.1 8.3e-13 48.0 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EWC48091.1 - 4.7e-12 45.3 0.0 9.4e-12 44.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR PF03114.18 EWC48091.1 - 2.3e-09 37.3 0.4 4.8e-09 36.2 0.2 1.6 1 1 0 1 1 1 1 BAR domain SH3_2 PF07653.17 EWC48091.1 - 5.3e-07 29.2 0.0 8.9e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PspA_IM30 PF04012.12 EWC48091.1 - 0.0016 18.1 0.0 0.0063 16.1 0.0 1.9 1 1 0 1 1 1 1 PspA/IM30 family BAR_3 PF16746.5 EWC48091.1 - 0.0033 17.2 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 BAR domain of APPL family APG17 PF04108.12 EWC48091.1 - 0.061 12.4 1.0 0.69 9.0 0.3 2.1 2 0 0 2 2 2 0 Autophagy protein Apg17 CEP63 PF17045.5 EWC48091.1 - 0.076 12.9 1.7 0.13 12.2 1.7 1.4 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa EzrA PF06160.12 EWC48091.1 - 0.11 10.7 1.1 0.49 8.5 0.2 2.2 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Seryl_tRNA_N PF02403.22 EWC48091.1 - 0.16 12.2 2.4 3.3 8.0 0.0 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4337 PF14235.6 EWC48091.1 - 9.8 6.3 6.7 6.1 6.9 4.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) PUL PF08324.11 EWC48092.1 - 1.8e-52 178.3 0.2 2.5e-52 177.8 0.2 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 EWC48092.1 - 4.7e-38 129.9 0.1 1e-37 128.8 0.1 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EWC48092.1 - 8.4e-29 99.2 19.3 3.4e-05 24.5 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 EWC48092.1 - 0.00082 19.4 0.0 0.085 12.9 0.0 3.3 2 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Septin PF00735.18 EWC48093.1 - 8.2e-110 366.5 0.0 1.5e-109 365.6 0.0 1.4 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EWC48093.1 - 8.3e-06 25.9 0.0 1.9e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EWC48093.1 - 0.00089 18.8 0.1 0.051 13.1 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EWC48093.1 - 0.0012 18.9 4.2 0.64 10.1 0.0 3.1 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 EWC48093.1 - 0.0014 18.6 2.6 0.0037 17.2 0.2 2.6 3 1 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 EWC48093.1 - 0.003 16.9 0.0 0.0059 16.0 0.0 1.5 1 0 0 1 1 1 1 AIG1 family AAA_22 PF13401.6 EWC48093.1 - 0.26 11.6 0.1 0.26 11.6 0.1 2.1 2 1 0 2 2 2 0 AAA domain Ribosomal_S17e PF00833.18 EWC48093.1 - 0.54 10.2 4.9 1.3 9.0 4.9 1.6 1 0 0 1 1 1 0 Ribosomal S17 AAA_23 PF13476.6 EWC48093.1 - 2.8 8.4 9.3 30 5.0 8.1 2.2 2 0 0 2 2 2 0 AAA domain TPD52 PF04201.15 EWC48093.1 - 9.7 5.8 8.0 16 5.0 8.0 1.4 1 0 0 1 1 1 0 Tumour protein D52 family WD40 PF00400.32 EWC48094.1 - 2.8e-27 94.4 17.2 2.6e-08 34.4 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48094.1 - 4.6e-10 39.7 0.0 0.52 10.7 0.0 5.3 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EWC48094.1 - 3.9e-06 26.1 0.0 0.0019 17.2 0.0 2.9 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Proteasome_A_N PF10584.9 EWC48094.1 - 0.029 14.1 0.2 5.3 6.8 0.0 3.4 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 EWC48094.1 - 0.057 11.9 0.1 0.79 8.2 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain bVLRF1 PF18826.1 EWC48095.1 - 3.2e-62 208.8 1.3 3.3e-62 208.8 0.1 1.7 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EWC48095.1 - 0.0016 18.7 0.1 0.003 17.8 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Mac PF12464.8 EWC48095.1 - 0.09 13.0 0.0 0.53 10.6 0.0 2.3 2 0 0 2 2 2 0 Maltose acetyltransferase RRM_1 PF00076.22 EWC48096.1 - 1.8e-16 59.7 0.0 4.5e-16 58.4 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EWC48096.1 - 0.019 15.1 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif RRM_1 PF00076.22 EWC48097.1 - 1.1e-18 66.8 0.0 6.6e-12 45.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC48097.1 - 0.0017 18.2 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif Response_reg PF00072.24 EWC48098.1 - 9.4e-19 67.6 0.1 8.7e-13 48.4 0.0 2.5 2 0 0 2 2 2 2 Response regulator receiver domain DUF3439 PF11921.8 EWC48098.1 - 0.001 19.0 3.6 0.001 19.0 3.6 2.2 3 0 0 3 3 2 1 Domain of unknown function (DUF3439) Draxin PF15550.6 EWC48098.1 - 0.072 13.0 3.5 0.13 12.1 3.5 1.4 1 0 0 1 1 1 0 Draxin Tim54 PF11711.8 EWC48098.1 - 0.14 10.9 4.1 0.24 10.2 4.1 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 GREB1 PF15782.5 EWC48098.1 - 0.63 7.1 4.1 0.94 6.5 4.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CPSF100_C PF13299.6 EWC48098.1 - 0.8 9.9 7.8 2 8.6 7.8 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3987 PF13148.6 EWC48098.1 - 2.2 7.2 6.0 3.7 6.5 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Roughex PF06020.11 EWC48098.1 - 4.8 6.2 9.2 9.3 5.2 9.2 1.4 1 0 0 1 1 1 0 Drosophila roughex protein RR_TM4-6 PF06459.12 EWC48098.1 - 5.4 6.8 7.7 9.2 6.0 7.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 EWC48098.1 - 5.7 5.1 16.4 9.4 4.4 16.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Plasmodium_Vir PF05795.11 EWC48098.1 - 7.4 5.9 7.3 13 5.1 7.3 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Ribosomal_S16 PF00886.19 EWC48100.1 - 2.3e-25 88.4 0.1 4e-25 87.6 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S16 PRP38 PF03371.15 EWC48101.1 - 2.2e-59 200.3 0.2 2.5e-59 200.1 0.2 1.0 1 0 0 1 1 1 1 PRP38 family Isy1 PF06246.12 EWC48102.1 - 1.4e-88 296.8 7.7 4.6e-88 295.1 7.7 1.7 1 1 0 1 1 1 1 Isy1-like splicing family YolD PF08863.10 EWC48102.1 - 0.032 14.3 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 YolD-like protein MMR_HSR1 PF01926.23 EWC48103.1 - 8.2e-14 51.7 0.0 1.6e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EWC48103.1 - 6.4e-06 26.2 0.4 2.1e-05 24.5 0.4 1.7 1 1 0 1 1 1 1 RsgA GTPase IIGP PF05049.13 EWC48103.1 - 1.4e-05 24.3 0.0 2.1e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 EWC48103.1 - 3e-05 23.6 0.0 5.2e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 EWC48103.1 - 0.011 14.7 0.1 0.018 14.0 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EWC48103.1 - 0.055 12.8 0.0 0.095 12.0 0.0 1.4 1 0 0 1 1 1 0 AIG1 family AAA_16 PF13191.6 EWC48103.1 - 0.085 13.2 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EWC48103.1 - 0.086 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EWC48103.1 - 0.12 12.9 1.4 0.15 12.6 0.2 1.7 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 EWC48103.1 - 0.17 11.0 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Dynamin_N PF00350.23 EWC48103.1 - 0.21 11.6 1.0 2.8 8.0 0.1 2.6 2 1 1 3 3 3 0 Dynamin family HCO3_cotransp PF00955.21 EWC48104.1 - 4e-79 266.8 11.6 1.3e-43 149.6 0.1 2.0 1 1 1 2 2 2 2 HCO3- transporter family DUF3341 PF11821.8 EWC48104.1 - 0.092 12.4 0.8 0.49 10.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) CPSF100_C PF13299.6 EWC48105.1 - 0.011 15.9 1.4 0.81 9.8 1.8 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FeoA PF04023.14 EWC48105.1 - 0.028 14.7 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 FeoA domain DUF5406 PF17400.2 EWC48105.1 - 0.08 13.4 0.0 0.32 11.4 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5406) Presenilin PF01080.17 EWC48105.1 - 0.081 11.7 1.9 0.13 11.0 1.9 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EWC48105.1 - 0.088 12.0 2.0 0.25 10.5 2.1 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter ORC_WH_C PF18137.1 EWC48105.1 - 0.15 12.2 6.6 0.29 11.2 6.6 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal RR_TM4-6 PF06459.12 EWC48105.1 - 0.31 10.8 6.1 0.55 10.0 6.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CLN3 PF02487.17 EWC48105.1 - 0.43 9.6 1.7 0.71 8.9 1.7 1.3 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 EWC48105.1 - 0.95 7.7 8.5 1.4 7.1 8.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 EWC48106.1 - 2.8e-52 177.7 0.0 4e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48106.1 - 1.3e-26 93.4 0.0 6.4e-26 91.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC48106.1 - 0.00024 20.5 0.0 0.0016 17.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EWC48106.1 - 0.066 12.8 0.1 0.32 10.6 0.0 1.9 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF2052 PF09747.9 EWC48107.1 - 5.1e-30 105.1 14.7 6.1e-30 104.8 14.7 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) TOBE_3 PF12857.7 EWC48107.1 - 0.12 12.2 0.2 0.25 11.3 0.2 1.5 1 0 0 1 1 1 0 TOBE-like domain WD40 PF00400.32 EWC48108.1 - 4.9e-08 33.5 0.1 0.015 16.1 0.0 3.3 2 1 1 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48108.1 - 1.7e-05 25.0 0.0 0.045 14.1 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EWC48108.1 - 0.00059 18.9 0.1 0.25 10.2 0.0 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 EWC48108.1 - 0.013 14.6 0.1 2.2 7.3 0.0 2.4 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain Nbas_N PF15492.6 EWC48108.1 - 0.14 11.4 0.0 1.2 8.4 0.0 2.2 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DLIC PF05783.11 EWC48109.1 - 3.2e-43 148.2 0.6 8.4e-37 127.1 0.0 3.0 2 2 1 3 3 3 2 Dynein light intermediate chain (DLIC) RabGAP-TBC PF00566.18 EWC48110.1 - 7e-49 166.4 0.0 1.4e-48 165.4 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 EWC48110.1 - 1.2e-13 51.0 0.1 2.4e-13 50.0 0.1 1.5 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.6 EWC48110.1 - 0.0003 20.5 0.5 0.015 15.2 0.2 3.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EWC48110.1 - 0.02 15.3 1.9 0.065 13.7 0.4 2.6 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EWC48110.1 - 0.026 14.1 2.6 0.083 12.5 0.8 2.9 4 0 0 4 4 4 0 EF hand EF-hand_5 PF13202.6 EWC48110.1 - 0.043 13.3 0.3 0.14 11.7 0.3 1.9 1 0 0 1 1 1 0 EF hand Filament PF00038.21 EWC48111.1 - 1.3e-05 24.9 21.9 2.6e-05 24.0 21.9 1.3 1 0 0 1 1 1 1 Intermediate filament protein GAS PF13851.6 EWC48111.1 - 0.0039 16.6 10.9 0.0039 16.6 10.9 2.7 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EWC48111.1 - 0.026 13.4 29.0 0.26 10.1 17.5 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein EF-hand_7 PF13499.6 EWC48111.1 - 0.06 13.8 0.2 0.06 13.8 0.2 3.6 3 1 1 4 4 4 0 EF-hand domain pair CALCOCO1 PF07888.11 EWC48111.1 - 0.13 11.1 28.3 0.32 9.8 28.3 1.6 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like EF-hand_6 PF13405.6 EWC48111.1 - 0.28 11.2 3.3 0.76 9.9 1.9 2.4 2 0 0 2 2 2 0 EF-hand domain KASH_CCD PF14662.6 EWC48111.1 - 0.29 10.9 33.0 0.091 12.6 14.6 2.7 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH ATG16 PF08614.11 EWC48111.1 - 0.3 11.3 32.9 0.064 13.5 10.5 4.0 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DivIC PF04977.15 EWC48111.1 - 0.33 10.7 24.6 2.7 7.8 0.3 4.9 1 1 3 4 4 4 0 Septum formation initiator Golgin_A5 PF09787.9 EWC48111.1 - 0.69 9.3 29.5 3.7 6.9 14.8 2.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 NPV_P10 PF05531.12 EWC48111.1 - 0.93 10.0 4.7 1.2 9.7 0.9 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein BRE1 PF08647.11 EWC48111.1 - 1.2 9.3 28.3 0.17 12.0 8.0 5.0 2 1 3 5 5 5 0 BRE1 E3 ubiquitin ligase SHE3 PF17078.5 EWC48111.1 - 1.4 8.6 19.9 0.019 14.7 9.4 2.3 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Fez1 PF06818.15 EWC48111.1 - 1.9 8.9 33.4 0.15 12.5 1.5 2.7 2 1 1 3 3 2 0 Fez1 DUF948 PF06103.11 EWC48111.1 - 1.9 8.8 5.4 20 5.5 0.1 3.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Macoilin PF09726.9 EWC48111.1 - 3.4 6.1 17.0 0.086 11.4 8.1 2.1 2 0 0 2 2 2 0 Macoilin family MAD PF05557.13 EWC48111.1 - 3.5 5.9 26.9 7 4.9 26.9 1.5 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF1192 PF06698.11 EWC48111.1 - 3.9 7.6 10.7 26 5.0 4.8 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF724 PF05266.14 EWC48111.1 - 4.9 6.9 20.2 2.1 8.2 6.9 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Bacillus_HBL PF05791.11 EWC48111.1 - 5.5 6.8 8.2 21 4.9 1.2 2.5 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Lebercilin PF15619.6 EWC48111.1 - 5.6 6.6 30.7 4.1 7.0 12.8 2.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4200 PF13863.6 EWC48111.1 - 6.4 7.2 32.9 1.9 8.9 18.1 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Atg14 PF10186.9 EWC48111.1 - 6.9 5.7 24.0 1.4e+03 -1.9 24.1 2.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exo_endo_phos PF03372.23 EWC48112.1 - 2.8e-06 27.0 0.2 1e-05 25.2 0.2 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ATG27 PF09451.10 EWC48113.1 - 0.0025 17.7 0.0 0.0041 17.0 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 27 LCAT PF02450.15 EWC48115.1 - 4.4e-103 345.5 0.1 7.1e-103 344.8 0.1 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase zf-C3H1 PF10650.9 EWC48116.1 - 3.3e-10 39.5 3.5 5.5e-10 38.8 3.5 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain Med8 PF10232.9 EWC48117.1 - 2.2e-26 92.9 0.0 2.7e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Ribosomal_60s PF00428.19 EWC48117.1 - 0.17 12.5 0.9 0.35 11.5 0.9 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein CDC45 PF02724.14 EWC48117.1 - 1.1 7.5 5.7 1.2 7.3 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EWC48117.1 - 1.4 8.1 10.7 2 7.7 10.7 1.1 1 0 0 1 1 1 0 NOA36 protein GCIP PF13324.6 EWC48117.1 - 1.9 8.0 3.9 2.9 7.4 3.9 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Nop14 PF04147.12 EWC48117.1 - 2.8 6.1 7.4 3.5 5.7 7.4 1.1 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 EWC48117.1 - 5.1 7.5 11.2 2.2 8.7 8.9 1.6 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Myosin_head PF00063.21 EWC48118.1 - 2.7e-272 905.0 1.4 1.2e-271 902.8 1.4 2.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.19 EWC48118.1 - 3.2e-10 39.7 2.8 7e-10 38.6 2.8 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_tail_1 PF01576.19 EWC48118.1 - 4.8e-09 34.7 283.6 1.7e-07 29.5 151.7 6.3 1 1 1 2 2 2 2 Myosin tail XPC-binding PF09280.11 EWC48118.1 - 0.03 14.0 6.2 0.35 10.6 0.0 4.1 3 0 0 3 3 3 0 XPC-binding domain AAA_22 PF13401.6 EWC48118.1 - 0.23 11.7 0.0 0.23 11.7 0.0 6.8 6 1 0 6 6 6 0 AAA domain Ferrochelatase PF00762.19 EWC48119.1 - 1.1e-103 346.6 0.0 1.3e-103 346.4 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase MP PF01107.18 EWC48119.1 - 0.24 10.9 0.0 0.38 10.3 0.0 1.2 1 0 0 1 1 1 0 Viral movement protein (MP) Acyl-CoA_dh_1 PF00441.24 EWC48120.1 - 1.3e-40 139.0 1.6 1.3e-40 139.0 1.6 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EWC48120.1 - 2.7e-32 111.8 0.1 7.3e-32 110.4 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EWC48120.1 - 7.6e-26 90.2 0.2 1.5e-25 89.2 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EWC48120.1 - 2e-14 54.0 0.8 2e-14 54.0 0.8 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EWC48120.1 - 0.018 14.8 0.1 0.09 12.4 0.1 2.0 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Carboxyl_trans PF01039.22 EWC48121.1 - 1.8e-142 475.5 1.9 2.2e-142 475.2 1.9 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 EWC48121.1 - 0.00034 20.2 0.6 0.42 10.1 0.3 2.5 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) Peptidase_S8 PF00082.22 EWC48122.1 - 1.7e-37 129.3 8.9 2.9e-37 128.5 8.9 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EWC48122.1 - 1.5e-14 54.4 0.0 4.9e-14 52.7 0.0 1.9 1 1 0 1 1 1 1 Peptidase inhibitor I9 Abhydrolase_1 PF00561.20 EWC48123.1 - 1.1e-43 149.7 0.0 6.9e-43 147.1 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EWC48123.1 - 2.1e-05 24.3 0.0 3.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Gly_transf_sug PF04488.15 EWC48124.1 - 2.1e-14 53.9 0.0 4.3e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Beach PF02138.18 EWC48126.1 - 5.9e-120 399.8 0.0 1.1e-119 399.0 0.0 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EWC48126.1 - 5.7e-10 39.2 0.0 1.6e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EWC48126.1 - 1.1e-09 38.6 0.0 2.2e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4704 PF15787.5 EWC48126.1 - 1.9e-08 33.9 0.0 5.1e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4704) WD40 PF00400.32 EWC48126.1 - 9.6e-05 23.1 12.0 0.0045 17.8 0.4 5.0 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48126.1 - 0.0059 16.9 0.1 1 9.7 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Serine_rich PF08824.10 EWC48126.1 - 0.12 12.4 0.1 0.67 9.9 0.1 2.3 3 0 0 3 3 3 0 Serine rich protein interaction domain HET PF06985.11 EWC48128.1 - 9.3e-08 32.5 1.2 8.9e-05 22.9 0.0 2.8 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Sod_Cu PF00080.20 EWC48130.1 - 3.2e-46 157.0 3.5 3.7e-46 156.8 3.5 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CNH PF00780.22 EWC48131.1 - 2e-70 237.5 0.0 3.2e-70 236.9 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EWC48131.1 - 1.8e-32 113.0 0.2 2.8e-32 112.4 0.2 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 EWC48131.1 - 1.9e-11 44.2 0.0 8.4e-11 42.1 0.0 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EWC48131.1 - 0.0047 17.4 0.0 0.26 11.8 0.0 2.6 2 0 0 2 2 2 1 PH domain DUF1492 PF07374.11 EWC48131.1 - 1.8 8.8 5.8 0.38 10.9 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) YjeF_N PF03853.15 EWC48132.1 - 8.4e-33 113.7 0.0 9.8e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 YjeF-related protein N-terminus His_Phos_1 PF00300.22 EWC48133.1 - 1.3e-07 31.5 0.0 2.2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RTC PF01137.21 EWC48134.1 - 1.1e-49 168.6 0.0 1.4e-49 168.3 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase DS PF01916.17 EWC48135.1 - 8.6e-135 448.6 0.0 9.9e-135 448.4 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase ERCC4 PF02732.15 EWC48136.1 - 6e-24 85.0 0.2 2e-23 83.3 0.0 1.9 2 1 0 2 2 2 1 ERCC4 domain Membr_traf_MHD PF10540.9 EWC48136.1 - 0.15 12.2 1.2 0.47 10.6 1.2 1.8 1 0 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain NARP1 PF12569.8 EWC48136.1 - 4.2 6.2 11.6 8.5 5.2 8.1 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 RMI1_N PF08585.12 EWC48136.1 - 7.5 6.2 8.0 6.9 6.4 4.1 2.7 2 1 0 2 2 2 0 RecQ mediated genome instability protein Glyco_hydro_17 PF00332.18 EWC48138.1 - 3.3e-06 26.9 2.0 6.6e-06 25.9 0.5 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 F-box-like PF12937.7 EWC48140.1 - 0.0053 16.6 0.1 0.014 15.3 0.1 1.8 1 0 0 1 1 1 1 F-box-like RNA_pol_Rpb6 PF01192.22 EWC48141.1 - 2.8e-15 55.9 0.0 3.3e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb6 DUF4549 PF15082.6 EWC48141.1 - 0.034 13.9 0.0 0.034 13.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) DUF1932 PF09130.11 EWC48142.1 - 1.3e-20 73.1 0.5 2.9e-20 72.0 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1932) NAD_binding_2 PF03446.15 EWC48142.1 - 0.063 13.4 0.0 0.17 12.1 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Glyco_transf_15 PF01793.16 EWC48144.1 - 2.5e-97 326.0 11.5 1.8e-96 323.2 11.5 1.9 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF4604 PF15377.6 EWC48145.1 - 1.1e-23 84.5 19.8 1.3e-23 84.3 19.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) CDC45 PF02724.14 EWC48145.1 - 0.25 9.6 7.2 0.31 9.3 7.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EWC48145.1 - 1.4 7.6 4.9 1.5 7.5 4.9 1.1 1 0 0 1 1 1 0 Presenilin Prp19 PF08606.11 EWC48146.1 - 2.3e-34 117.2 1.1 4e-34 116.4 1.1 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EWC48146.1 - 8.6e-13 48.4 0.3 0.00035 20.8 0.1 4.8 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EWC48146.1 - 4.2e-09 36.9 7.4 0.38 11.7 0.0 6.4 6 0 0 6 6 6 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EWC48146.1 - 4.9e-05 22.6 0.0 0.015 14.3 0.1 2.2 1 1 1 2 2 2 2 Coatomer WD associated region eIF2A PF08662.11 EWC48146.1 - 0.00084 19.3 0.0 0.031 14.2 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A zf-Nse PF11789.8 EWC48146.1 - 0.0011 18.7 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Cytochrom_D1 PF02239.16 EWC48146.1 - 0.0099 14.4 0.0 0.021 13.4 0.0 1.5 1 1 0 1 1 1 1 Cytochrome D1 heme domain Peptidase_M23 PF01551.22 EWC48146.1 - 0.11 12.7 0.1 3 8.1 0.0 2.5 2 0 0 2 2 2 0 Peptidase family M23 zf-RING_5 PF14634.6 EWC48147.1 - 0.00012 21.9 6.8 0.00021 21.2 6.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EWC48147.1 - 0.0042 17.4 3.3 0.0098 16.2 3.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC48147.1 - 0.0067 16.2 0.5 0.015 15.1 0.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC48147.1 - 0.033 14.2 3.4 0.074 13.1 3.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger BIR PF00653.21 EWC48147.1 - 0.049 14.3 2.3 0.093 13.4 1.3 2.0 1 1 1 2 2 2 0 Inhibitor of Apoptosis domain zf-C3HC4 PF00097.25 EWC48147.1 - 0.24 11.3 4.5 0.49 10.3 4.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC48147.1 - 0.38 10.6 9.5 1.2 9.1 9.5 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PTPLA PF04387.14 EWC48148.1 - 3.1e-54 183.1 4.5 4.6e-54 182.6 4.5 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Adaptin_binding PF10199.9 EWC48149.1 - 1.5e-17 64.4 6.5 1.5e-17 64.4 6.5 1.6 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 LSM PF01423.22 EWC48150.1 - 9.6e-16 57.2 0.2 1.3e-15 56.8 0.2 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EWC48150.1 - 0.063 13.4 0.1 0.12 12.6 0.1 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain CTU2 PF10288.9 EWC48151.1 - 9.6e-10 38.7 0.0 3e-09 37.1 0.0 1.8 2 0 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 ATP_bind_3 PF01171.20 EWC48151.1 - 5.9e-05 22.9 0.1 0.1 12.3 0.0 2.5 2 1 0 3 3 3 2 PP-loop family DZR PF12773.7 EWC48151.1 - 0.21 11.7 9.7 0.47 10.5 1.2 2.9 2 1 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 EWC48151.1 - 1.3 9.1 3.6 7.5 6.6 0.4 2.9 3 0 0 3 3 3 0 zinc-ribbons CorA PF01544.18 EWC48152.1 - 7.1e-32 110.9 5.2 2e-28 99.5 1.9 2.6 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein Cation_efflux PF01545.21 EWC48155.1 - 4.2e-13 49.5 12.7 5.3e-13 49.2 12.7 1.1 1 0 0 1 1 1 1 Cation efflux family EF-hand_7 PF13499.6 EWC48156.1 - 0.0013 19.1 1.9 0.13 12.8 0.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair Nup192 PF11894.8 EWC48157.1 - 0 1139.8 8.0 0 1139.6 8.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 PhoU_div PF01865.16 EWC48157.1 - 0.0051 16.2 0.7 2 7.7 0.2 2.5 2 0 0 2 2 2 2 Protein of unknown function DUF47 PI3_PI4_kinase PF00454.27 EWC48158.1 - 1.8e-51 175.4 0.0 3.9e-51 174.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EWC48158.1 - 6.5e-36 123.7 4.7 1.9e-35 122.2 2.0 3.2 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 EWC48158.1 - 1.8e-09 37.2 0.0 6.5e-09 35.4 0.0 2.1 1 0 0 1 1 1 1 FATC domain DinB PF05163.12 EWC48158.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 DinB family HEAT PF02985.22 EWC48158.1 - 0.54 10.7 3.2 18 5.9 0.0 4.5 5 0 0 5 5 5 0 HEAT repeat DNApol_Exo PF18136.1 EWC48159.1 - 1.4e-95 319.7 0.3 3.4e-95 318.4 0.3 1.7 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EWC48159.1 - 4.6e-57 193.8 0.0 4.6e-57 193.8 0.0 3.4 4 0 0 4 4 4 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 EWC48159.1 - 0.00031 20.5 2.0 0.004 16.9 2.0 2.6 1 1 0 1 1 1 1 3'-5' exonuclease DNA_pol_B_2 PF03175.13 EWC48159.1 - 0.054 12.3 0.0 0.12 11.2 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral zf-C3HC4_3 PF13920.6 EWC48160.1 - 3e-12 46.2 4.8 4.3e-12 45.7 4.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC48160.1 - 6.3e-09 35.6 7.9 9.7e-09 35.0 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC48160.1 - 4.8e-08 33.2 7.6 7.5e-08 32.6 7.6 1.3 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EWC48160.1 - 1.3e-07 31.3 6.5 2.2e-07 30.6 6.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EWC48160.1 - 3.2e-07 30.2 7.0 5.4e-07 29.5 7.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EWC48160.1 - 6e-07 29.2 8.8 1.3e-06 28.2 8.8 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EWC48160.1 - 1.4e-06 28.2 4.6 1.4e-06 28.2 4.6 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EWC48160.1 - 0.015 15.6 3.1 0.029 14.7 3.1 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EWC48160.1 - 0.015 15.1 4.2 0.042 13.6 4.2 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EWC48160.1 - 0.017 15.3 6.9 0.035 14.3 6.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SDA1 PF05285.12 EWC48160.1 - 0.023 14.2 9.6 0.032 13.7 9.6 1.1 1 0 0 1 1 1 0 SDA1 zf-ANAPC11 PF12861.7 EWC48160.1 - 0.035 14.2 0.9 0.058 13.4 0.9 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EWC48160.1 - 0.14 12.1 3.6 0.34 10.8 3.6 1.5 1 1 0 1 1 1 0 zf-RING of BARD1-type protein RNA_polI_A34 PF08208.11 EWC48160.1 - 0.16 12.0 2.0 0.26 11.4 2.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TFIIF_alpha PF05793.12 EWC48160.1 - 0.26 9.8 8.9 0.36 9.4 8.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zf-RING_10 PF16685.5 EWC48160.1 - 0.39 10.9 5.9 0.89 9.7 5.9 1.5 1 1 0 1 1 1 0 zinc RING finger of MSL2 Prim_Zn_Ribbon PF08273.12 EWC48160.1 - 0.54 10.6 4.6 8.5 6.7 1.2 2.4 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Nop14 PF04147.12 EWC48160.1 - 2.3 6.3 11.8 2.6 6.2 11.8 1.1 1 0 0 1 1 1 0 Nop14-like family zf-RING_11 PF17123.5 EWC48160.1 - 2.7 7.8 8.2 0.66 9.8 4.2 2.1 2 1 0 2 2 2 0 RING-like zinc finger Tub_N PF16322.5 EWC48160.1 - 3.6 7.9 7.4 1.1 9.6 4.2 1.8 1 1 1 2 2 2 0 Tubby N-terminal CDC45 PF02724.14 EWC48160.1 - 8.3 4.6 9.1 11 4.2 9.1 1.1 1 0 0 1 1 1 0 CDC45-like protein LDB19 PF13002.7 EWC48161.1 - 4.6e-49 166.8 0.1 1.3e-48 165.3 0.1 1.7 2 0 0 2 2 2 1 Arrestin_N terminal like Arrestin_N PF00339.29 EWC48161.1 - 6.2e-06 26.3 0.2 3.7e-05 23.8 0.0 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Amidohydro_2 PF04909.14 EWC48162.1 - 1.1e-15 58.2 0.2 3.3e-15 56.6 0.2 1.7 1 1 0 1 1 1 1 Amidohydrolase DIOX_N PF14226.6 EWC48163.1 - 3.6e-21 76.1 0.0 5.6e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EWC48163.1 - 2e-14 53.9 0.0 3.3e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cofilin_ADF PF00241.20 EWC48165.1 - 2.1e-05 24.3 0.0 3.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein EXOSC1 PF10447.9 EWC48167.1 - 1.9e-16 60.6 6.9 1.8e-11 44.6 1.0 2.5 2 1 1 3 3 3 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EWC48167.1 - 1.3e-09 37.6 1.8 4.2e-09 36.0 1.7 2.0 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region CRAL_TRIO PF00650.20 EWC48168.1 - 2.9e-35 121.3 0.0 4e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EWC48168.1 - 2.9e-17 62.6 0.4 5.1e-17 61.8 0.4 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EWC48168.1 - 0.0015 18.7 0.0 0.0023 18.1 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pol_alpha_B_N PF08418.10 EWC48169.1 - 1.3e-62 212.0 0.0 2.1e-62 211.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EWC48169.1 - 6.8e-27 94.2 0.2 1e-26 93.6 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B UreD PF01774.17 EWC48170.1 - 1e-65 221.7 0.4 1.2e-65 221.4 0.4 1.1 1 0 0 1 1 1 1 UreD urease accessory protein GATase_4 PF13230.6 EWC48171.1 - 3e-16 59.1 0.0 2.6e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EWC48171.1 - 1.4e-08 35.0 0.0 2.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Dynamin_N PF00350.23 EWC48172.1 - 1.3e-43 148.9 0.0 2.7e-43 147.9 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EWC48172.1 - 3.9e-15 55.8 0.1 2.4e-12 46.7 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EWC48172.1 - 3.1e-05 24.0 0.0 0.00014 21.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EWC48172.1 - 0.039 13.7 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EWC48172.1 - 0.16 12.4 2.0 0.53 10.6 0.1 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.6 EWC48172.1 - 0.24 11.1 0.0 0.24 11.1 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain SRI PF08236.11 EWC48172.1 - 0.41 10.8 1.9 0.77 10.0 0.1 2.4 3 0 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain FAD_binding_7 PF03441.14 EWC48173.1 - 8.5e-77 257.2 0.1 1.3e-76 256.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EWC48173.1 - 1.6e-42 145.3 0.0 2.6e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase Secapin PF17521.2 EWC48173.1 - 0.072 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Honey bee peptides PH PF00169.29 EWC48174.1 - 4.3e-34 117.2 4.0 2.8e-18 66.3 0.2 2.1 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EWC48174.1 - 6.6e-09 36.2 2.9 0.0006 20.2 0.1 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 EWC48174.1 - 3.4e-08 33.9 13.2 0.0026 18.2 2.0 4.0 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EWC48174.1 - 1.7e-06 28.2 1.6 2e-05 24.8 0.1 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 EWC48174.1 - 0.12 12.7 0.0 4 7.7 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain LLC1 PF14945.6 EWC48174.1 - 0.26 11.9 2.3 2.6 8.7 0.3 2.5 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein BCL_N PF04714.13 EWC48174.1 - 1.1 9.4 9.4 1.8 8.7 0.7 2.4 2 0 0 2 2 2 0 BCL7, N-terminal conserver region MLD PF11647.8 EWC48175.1 - 0.056 13.7 0.1 0.056 13.7 0.1 2.9 3 0 0 3 3 3 0 Membrane Localization Domain TruB_C_2 PF16198.5 EWC48175.1 - 0.14 12.3 0.5 0.85 9.8 0.5 2.4 1 0 0 1 1 1 0 tRNA pseudouridylate synthase B C-terminal domain PIG-Y PF15159.6 EWC48176.1 - 1.2e-19 70.9 7.1 1.8e-19 70.4 7.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y CENP-B_dimeris PF09026.10 EWC48176.1 - 0.00013 22.3 4.5 0.0066 16.8 3.3 2.2 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EWC48176.1 - 0.14 11.9 2.1 0.17 11.6 2.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF1218 PF06749.12 EWC48176.1 - 0.24 11.9 6.1 1 9.9 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) NOA36 PF06524.12 EWC48176.1 - 0.25 10.6 1.9 0.34 10.2 1.9 1.2 1 0 0 1 1 1 0 NOA36 protein DUF3040 PF11239.8 EWC48176.1 - 8.1 6.8 6.8 0.61 10.4 0.3 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) DNA_pol_phi PF04931.13 EWC48176.1 - 9.2 4.2 4.7 12 3.9 4.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Cullin_binding PF03556.15 EWC48177.1 - 4.2e-32 111.1 2.2 5.6e-32 110.7 2.2 1.2 1 0 0 1 1 1 1 Cullin binding SH3_1 PF00018.28 EWC48178.1 - 2.2e-05 24.0 0.0 4.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC48178.1 - 0.028 14.3 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain Pkinase PF00069.25 EWC48179.1 - 1.5e-45 155.6 0.0 2.9e-45 154.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48179.1 - 3e-28 98.8 0.1 2.5e-21 76.1 0.0 2.3 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EWC48179.1 - 0.0035 16.2 0.0 0.0055 15.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EWC48179.1 - 0.013 14.8 0.0 0.03 13.6 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 EWC48179.1 - 0.05 12.5 0.1 0.093 11.6 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EWC48179.1 - 0.082 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mpv17_PMP22 PF04117.12 EWC48180.1 - 3.2e-10 40.1 3.5 3.5e-10 40.0 1.0 2.1 1 1 1 2 2 2 1 Mpv17 / PMP22 family EII-GUT PF03608.13 EWC48180.1 - 0.029 14.3 1.1 0.044 13.7 1.1 1.4 1 0 0 1 1 1 0 PTS system enzyme II sorbitol-specific factor GTP_EFTU PF00009.27 EWC48181.1 - 1.7e-55 187.6 0.0 3.2e-55 186.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EWC48181.1 - 1.7e-15 56.8 0.2 6.3e-15 55.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EWC48181.1 - 1.2e-09 38.4 0.0 3.7e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EWC48181.1 - 2.8e-06 27.3 0.0 8.9e-06 25.7 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EWC48181.1 - 0.00012 21.8 0.1 0.00062 19.5 0.0 2.2 1 1 1 2 2 2 1 Elongation factor G, domain IV Mhr1 PF12829.7 EWC48182.1 - 1.3e-30 105.3 0.1 2.3e-30 104.5 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination PEX11 PF05648.14 EWC48183.1 - 1.1e-10 41.4 4.4 1.1e-06 28.2 5.4 2.6 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) SbcCD_C PF13558.6 EWC48183.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Snf7 PF03357.21 EWC48184.1 - 6e-31 107.3 22.2 6e-31 107.3 22.2 2.7 2 1 1 3 3 3 1 Snf7 Atg14 PF10186.9 EWC48184.1 - 4.6e-13 49.0 2.2 4.6e-13 49.0 2.2 2.7 2 1 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 APG6 PF04111.12 EWC48184.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 Apg6 BARA domain YlqD PF11068.8 EWC48184.1 - 2.9 8.3 25.0 3.1 8.2 6.5 2.9 2 1 1 3 3 3 0 YlqD protein Dynamin_N PF00350.23 EWC48185.1 - 1.4e-18 67.5 0.0 2.9e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EWC48185.1 - 1e-09 38.5 0.0 6.2e-09 35.9 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EWC48185.1 - 1.3e-06 28.1 0.7 6.2e-05 22.6 0.4 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EWC48185.1 - 0.0092 15.9 1.1 2.3 8.1 0.2 2.8 2 1 0 2 2 2 1 RsgA GTPase DUF3918 PF13056.6 EWC48185.1 - 0.0094 15.5 0.4 0.026 14.1 0.4 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3918) HDOD PF08668.12 EWC48185.1 - 0.018 14.5 0.1 0.041 13.3 0.1 1.6 1 0 0 1 1 1 0 HDOD domain cobW PF02492.19 EWC48185.1 - 0.032 13.8 0.1 1 8.9 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 EWC48185.1 - 0.048 12.7 0.0 0.097 11.7 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF2205 PF10224.9 EWC48185.1 - 0.05 13.6 0.1 0.17 11.9 0.1 1.9 1 0 0 1 1 1 0 Short coiled-coil protein TsaE PF02367.17 EWC48185.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EWC48185.1 - 0.069 13.7 0.0 0.26 11.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EWC48185.1 - 0.14 11.9 0.0 23 4.7 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF445 PF04286.12 EWC48185.1 - 0.24 11.2 2.2 5.8 6.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF445) IF3_C PF00707.22 EWC48186.1 - 9.2e-09 35.2 0.1 1.4e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 EWC48186.1 - 4.7e-05 23.1 0.6 7e-05 22.6 0.6 1.2 1 0 0 1 1 1 1 Mitochondrial translation initiation factor LSM PF01423.22 EWC48187.1 - 5.6e-18 64.4 0.1 7.6e-18 64.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain GATA PF00320.27 EWC48188.1 - 2.3e-06 27.1 1.9 2.8e-05 23.6 1.9 2.3 1 1 0 1 1 1 1 GATA zinc finger AT_hook PF02178.19 EWC48188.1 - 0.31 11.0 13.9 2.3 8.4 4.1 3.1 2 0 0 2 2 2 0 AT hook motif Rep_fac-A_3 PF08661.11 EWC48189.1 - 4.7e-23 81.5 0.6 5.3e-23 81.4 0.6 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Ribosomal_L35Ae PF01247.18 EWC48189.1 - 0.016 15.4 0.3 0.62 10.3 0.0 2.1 1 1 1 2 2 2 0 Ribosomal protein L35Ae CSD2 PF17876.1 EWC48189.1 - 0.11 12.7 1.6 0.29 11.3 1.6 1.7 1 1 0 1 1 1 0 Cold shock domain Peptidase_S26 PF10502.9 EWC48190.1 - 1.8e-07 31.1 0.0 0.00028 20.7 0.0 2.4 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EWC48190.1 - 1.5e-06 28.0 0.3 3e-06 27.1 0.3 1.5 1 0 0 1 1 1 1 Peptidase S24-like PBP PF01161.20 EWC48191.1 - 5e-09 36.6 0.0 1.1e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Ribosomal_L4 PF00573.22 EWC48192.1 - 5.2e-50 169.8 0.0 8.6e-50 169.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Glyco_hydro_2_N PF02837.18 EWC48192.1 - 0.039 13.9 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain RAMA PF18755.1 EWC48192.1 - 0.1 13.0 0.1 0.27 11.7 0.1 1.7 1 0 0 1 1 1 0 Restriction Enzyme Adenine Methylase Associated ECH_2 PF16113.5 EWC48193.1 - 1.1e-118 396.5 0.0 1.5e-118 396.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EWC48193.1 - 2.3e-25 89.4 0.0 5.1e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase bZIP_1 PF00170.21 EWC48194.1 - 1.4e-07 31.5 11.2 1.4e-07 31.5 11.2 2.3 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EWC48194.1 - 4.5e-05 23.4 9.6 4.5e-05 23.4 9.6 2.4 2 0 0 2 2 2 1 Basic region leucine zipper Phage_HK97_TLTM PF06120.11 EWC48194.1 - 0.00039 19.7 5.5 0.00051 19.3 4.2 1.6 1 1 0 1 1 1 1 Tail length tape measure protein PE_PPE_C PF12484.8 EWC48194.1 - 0.018 16.0 1.7 0.018 16.0 1.7 2.5 3 0 0 3 3 3 0 Polymorphic PE/PPE proteins C terminal bZIP_Maf PF03131.17 EWC48194.1 - 9.1 6.9 13.9 0.37 11.3 6.3 2.5 2 1 1 3 3 3 0 bZIP Maf transcription factor GTP_EFTU PF00009.27 EWC48195.1 - 5.3e-57 192.5 0.1 7.1e-57 192.1 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EWC48195.1 - 1.2e-26 93.2 0.0 3.1e-26 91.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EWC48195.1 - 4.2e-17 62.3 3.8 5.3e-17 62.0 2.7 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EWC48195.1 - 0.0001 22.4 0.0 0.00018 21.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EWC48195.1 - 0.011 15.6 0.0 0.031 14.2 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 EWC48195.1 - 0.012 15.2 0.4 0.05 13.2 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EWC48195.1 - 0.031 14.0 0.2 9.2 6.0 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 EWC48196.1 - 1.5e-20 73.5 0.1 2.9e-20 72.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EWC48196.1 - 9.4e-09 35.5 1.6 4.7e-08 33.3 1.2 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EWC48196.1 - 4.5e-06 26.9 0.0 1.9e-05 24.9 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EWC48196.1 - 0.0031 17.6 0.3 0.011 15.7 0.3 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EWC48196.1 - 0.011 15.4 0.9 1.2 8.9 0.3 3.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Phage_holin_7_1 PF16081.5 EWC48196.1 - 0.029 14.5 0.2 2 8.6 0.1 2.6 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Roc PF08477.13 EWC48196.1 - 0.19 12.0 0.5 3.5 7.8 0.1 2.6 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Ribonuc_red_sm PF00268.21 EWC48197.1 - 3.2e-123 410.6 0.8 4.1e-123 410.3 0.8 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 EWC48197.1 - 0.1 13.4 0.0 0.27 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) DUF1308 PF07000.11 EWC48198.1 - 2.7e-11 43.7 0.0 5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) DUF5614 PF18474.1 EWC48198.1 - 0.046 13.0 0.1 2.4 7.4 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5614) Lung_7-TM_R PF06814.13 EWC48199.1 - 8.8e-70 235.3 17.3 1.1e-69 235.0 17.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SurA_N_3 PF13624.6 EWC48199.1 - 1.1 9.0 4.8 0.48 10.2 0.4 2.4 2 0 0 2 2 2 0 SurA N-terminal domain PGP_phosphatase PF09419.10 EWC48200.1 - 4e-64 215.3 0.0 4.6e-64 215.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EWC48200.1 - 6e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Homeodomain PF00046.29 EWC48201.1 - 6e-19 67.6 3.7 1.7e-18 66.2 3.7 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EWC48201.1 - 0.0034 17.2 0.2 0.0086 16.0 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain PhoLip_ATPase_C PF16212.5 EWC48202.1 - 1.7e-63 214.7 26.1 1.7e-63 214.7 26.1 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EWC48202.1 - 4.5e-25 87.1 4.0 8.1e-24 83.1 0.4 2.7 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EWC48202.1 - 7e-13 49.3 0.4 1e-06 29.2 0.2 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EWC48202.1 - 9e-11 41.7 0.0 5.1e-10 39.3 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EWC48202.1 - 8.6e-10 38.4 0.8 2.5e-09 36.9 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EWC48202.1 - 0.00067 19.5 0.0 0.0023 17.7 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EWC48202.1 - 0.075 13.4 0.0 4.2 7.7 0.1 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Sec62 PF03839.16 EWC48202.1 - 1.2 8.5 3.4 5.8 6.4 3.4 2.2 1 0 0 1 1 1 0 Translocation protein Sec62 HXXEE PF13787.6 EWC48202.1 - 9.5 7.1 9.1 14 6.6 4.4 2.7 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif zf-MYND PF01753.18 EWC48203.1 - 1.2e-07 31.7 19.7 2.1e-07 30.9 19.7 1.4 1 0 0 1 1 1 1 MYND finger WD40 PF00400.32 EWC48204.1 - 1.4e-14 54.3 10.0 1e-06 29.3 0.0 5.4 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48204.1 - 3.3e-07 30.5 0.0 0.077 13.3 0.0 4.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EWC48204.1 - 0.11 12.4 0.0 6.9 6.5 0.0 3.2 3 2 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A EF-hand_12 PF17901.1 EWC48204.1 - 0.17 12.4 0.0 0.37 11.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand fold domain Mito_carr PF00153.27 EWC48205.1 - 2.6e-53 177.9 5.0 6.5e-18 64.5 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EWC48205.1 - 0.019 14.2 4.4 6 5.9 0.0 3.8 3 1 1 4 4 4 0 Gammaproteobacterial serine protease Tim17 PF02466.19 EWC48205.1 - 5.2 7.5 9.3 16 5.9 5.7 3.2 2 1 1 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family DIOX_N PF14226.6 EWC48206.1 - 8.6e-19 68.4 0.1 1.3e-18 67.8 0.1 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EWC48206.1 - 1.1e-14 54.7 0.0 3.1e-14 53.3 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily MKT1_C PF12246.8 EWC48207.1 - 1.6e-72 243.7 0.0 1.9e-71 240.1 0.0 2.1 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EWC48207.1 - 3e-29 101.2 0.0 1e-28 99.5 0.0 2.0 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EWC48207.1 - 0.018 15.5 0.0 0.053 14.0 0.0 1.7 1 0 0 1 1 1 0 XPG N-terminal domain XPG_I PF00867.18 EWC48207.1 - 0.025 14.9 0.0 0.054 13.8 0.0 1.6 1 0 0 1 1 1 0 XPG I-region WD40 PF00400.32 EWC48208.1 - 2.8e-28 97.6 7.6 4.2e-06 27.4 0.0 9.0 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48208.1 - 3.8e-06 27.1 0.0 1.3 9.4 0.0 4.5 3 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EWC48208.1 - 0.0057 15.4 0.7 1.6 7.4 0.1 3.6 2 2 1 3 3 3 1 Nup133 N terminal like BBS2_Mid PF14783.6 EWC48208.1 - 0.074 13.1 0.1 14 5.7 0.0 3.9 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.16 EWC48208.1 - 0.076 11.5 0.0 0.27 9.7 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EWC48208.1 - 0.11 11.5 0.0 3.1 6.7 0.0 2.9 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein OHCU_decarbox PF09349.10 EWC48210.1 - 6.5e-25 88.4 0.1 7.6e-25 88.2 0.1 1.0 1 0 0 1 1 1 1 OHCU decarboxylase VEK-30 PF12107.8 EWC48210.1 - 0.35 10.8 4.4 0.81 9.7 4.4 1.6 1 0 0 1 1 1 0 Plasminogen (Pg) ligand in fibrinolytic pathway S1 PF00575.23 EWC48211.1 - 6.5e-75 247.5 38.8 2.6e-13 50.1 0.1 12.4 12 0 0 12 12 12 11 S1 RNA binding domain Suf PF05843.14 EWC48211.1 - 9.2e-07 29.1 1.5 0.00017 21.7 0.3 3.0 2 1 1 3 3 3 2 Suppressor of forked protein (Suf) RNase_II_C_S1 PF18614.1 EWC48211.1 - 6.3e-06 26.0 2.7 0.37 10.8 0.3 6.3 6 1 0 6 6 6 2 RNase II-type exonuclease C-terminal S1 domain TPR_16 PF13432.6 EWC48211.1 - 6.2e-05 23.6 11.3 0.059 14.0 4.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat S1_2 PF13509.6 EWC48211.1 - 0.0001 22.3 0.1 0.32 11.1 0.0 5.2 4 0 0 4 4 4 1 S1 domain TPR_14 PF13428.6 EWC48211.1 - 0.00019 21.9 11.7 0.029 15.2 0.4 4.9 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48211.1 - 0.0006 20.3 9.3 0.0018 18.8 0.6 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EWC48211.1 - 0.002 17.3 0.2 0.072 12.2 0.2 2.8 2 1 1 3 3 3 1 NRDE-2, necessary for RNA interference Myosin_N PF02736.19 EWC48211.1 - 0.44 10.4 6.2 11 5.9 1.3 4.5 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain TPR_6 PF13174.6 EWC48211.1 - 1.6 9.5 5.9 1.1 10.1 0.5 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48211.1 - 1.9 8.9 5.0 6.9 7.0 0.4 3.3 2 1 0 3 3 3 0 Tetratricopeptide repeat Ras PF00071.22 EWC48212.1 - 5.7e-57 191.8 0.1 7e-57 191.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC48212.1 - 7.3e-33 113.3 0.1 1.1e-32 112.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC48212.1 - 5.8e-14 51.9 0.0 7.3e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EWC48212.1 - 7.4e-08 32.5 0.0 1.1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EWC48212.1 - 6.7e-06 25.8 0.1 0.00019 21.0 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EWC48212.1 - 1.4e-05 24.6 0.0 1.7e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EWC48212.1 - 5e-05 23.3 0.1 0.0027 17.6 0.1 2.4 1 1 1 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EWC48212.1 - 0.0014 19.0 0.0 0.0025 18.2 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.17 EWC48212.1 - 0.0031 17.3 0.3 0.083 12.7 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EWC48212.1 - 0.0034 17.1 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EWC48212.1 - 0.0055 16.2 0.1 0.0091 15.5 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Septin PF00735.18 EWC48212.1 - 0.0057 16.0 0.1 0.036 13.4 0.0 2.0 2 0 0 2 2 2 1 Septin AAA_22 PF13401.6 EWC48212.1 - 0.0067 16.7 0.0 0.021 15.1 0.0 1.7 1 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EWC48212.1 - 0.0091 15.7 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EWC48212.1 - 0.0092 15.6 0.0 0.021 14.4 0.0 1.6 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EWC48212.1 - 0.0098 15.9 0.0 0.017 15.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) SRPRB PF09439.10 EWC48212.1 - 0.011 15.2 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Sigma54_activat PF00158.26 EWC48212.1 - 0.035 13.8 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EWC48212.1 - 0.036 14.0 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 EWC48212.1 - 0.041 13.1 0.0 0.063 12.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Glyco_hydro_75 PF07335.11 EWC48212.1 - 0.045 14.0 0.0 0.079 13.2 0.0 1.5 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 ATPase_2 PF01637.18 EWC48212.1 - 0.05 13.5 0.1 0.08 12.8 0.1 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DAP3 PF10236.9 EWC48212.1 - 0.058 12.6 0.2 0.097 11.8 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MCM PF00493.23 EWC48212.1 - 0.075 12.1 0.1 0.1 11.7 0.1 1.2 1 0 0 1 1 1 0 MCM P-loop domain TniB PF05621.11 EWC48212.1 - 0.095 12.1 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EWC48212.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain G-alpha PF00503.20 EWC48212.1 - 0.16 11.1 0.4 0.37 9.9 0.1 1.6 1 1 1 2 2 2 0 G-protein alpha subunit ATG16 PF08614.11 EWC48213.1 - 1e-44 153.2 16.5 1.2e-44 153.0 16.5 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Cluap1 PF10234.9 EWC48213.1 - 0.00037 20.0 3.3 0.00055 19.4 3.3 1.3 1 0 0 1 1 1 1 Clusterin-associated protein-1 APG6_N PF17675.1 EWC48213.1 - 0.008 16.7 16.0 0.096 13.2 3.5 2.5 1 1 1 3 3 3 2 Apg6 coiled-coil region zf-C4H2 PF10146.9 EWC48213.1 - 0.1 12.9 11.2 0.035 14.4 7.7 1.8 1 1 1 2 2 2 0 Zinc finger-containing protein DUF4201 PF13870.6 EWC48213.1 - 0.12 12.1 12.9 0.27 11.0 12.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) ADIP PF11559.8 EWC48213.1 - 0.16 12.1 18.3 0.55 10.3 13.5 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GvpG PF05120.12 EWC48213.1 - 0.23 11.5 8.2 0.053 13.5 2.5 2.5 2 1 0 2 2 2 0 Gas vesicle protein G THOC7 PF05615.13 EWC48213.1 - 0.28 11.5 11.7 0.44 10.8 11.7 1.6 1 1 0 1 1 1 0 Tho complex subunit 7 DUF4795 PF16043.5 EWC48213.1 - 0.3 10.7 9.2 0.48 10.0 9.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) UPF0242 PF06785.11 EWC48213.1 - 0.36 10.9 10.7 3 7.9 7.7 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3446 PF11928.8 EWC48213.1 - 0.42 10.9 6.6 0.83 10.0 6.6 1.4 1 0 0 1 1 1 0 Early growth response N-terminal domain CENP-F_leu_zip PF10473.9 EWC48213.1 - 0.5 10.4 12.4 0.44 10.6 3.2 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4239 PF14023.6 EWC48213.1 - 0.67 9.6 4.1 1 9.1 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) CENP-H PF05837.12 EWC48213.1 - 1.7 9.1 15.9 8.2 6.9 4.1 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF4407 PF14362.6 EWC48213.1 - 3.3 7.0 14.4 0.29 10.4 10.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DOT1 PF08123.13 EWC48214.1 - 6.5e-63 212.0 0.0 9.1e-63 211.5 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.20 EWC48214.1 - 0.0023 17.3 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EWC48214.1 - 0.16 12.7 0.0 0.45 11.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PBP_sp32 PF07222.12 EWC48215.1 - 0.4 10.1 5.0 1.2 8.6 5.0 1.8 1 0 0 1 1 1 0 Proacrosin binding protein sp32 RskA PF10099.9 EWC48215.1 - 0.5 10.6 11.3 0.51 10.6 7.2 2.7 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DnaJ_C PF01556.18 EWC48216.1 - 2.5e-35 121.8 0.3 3.3e-35 121.3 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EWC48216.1 - 1.2e-12 48.0 18.9 2.5e-12 47.0 18.9 1.5 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 EWC48216.1 - 4.5e-10 39.5 1.7 8.2e-10 38.7 1.7 1.4 1 0 0 1 1 1 1 DnaJ domain DUF1356 PF07092.12 EWC48216.1 - 0.004 16.5 2.8 0.21 10.8 0.3 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 EWC48216.1 - 0.73 9.8 21.9 2.8 8.0 5.5 2.6 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein tRNA-synt_1c PF00749.21 EWC48217.1 - 3.4e-75 252.9 0.0 7.1e-70 235.4 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain WD40 PF00400.32 EWC48218.1 - 3.4e-20 72.0 14.7 0.0004 21.1 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48218.1 - 3.2e-07 30.6 0.0 5.5 7.4 0.0 5.5 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EWC48218.1 - 1.7e-06 27.3 0.2 0.26 10.2 0.0 3.3 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EWC48218.1 - 0.0087 14.8 0.0 0.028 13.1 0.0 1.7 1 1 1 2 2 2 1 Nucleoporin Nup120/160 DUF2415 PF10313.9 EWC48218.1 - 0.02 14.8 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) WD40_like PF17005.5 EWC48218.1 - 0.041 13.2 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain Spb1_C PF07780.12 EWC48219.1 - 4.3e-78 261.8 27.8 4.3e-78 261.8 27.8 4.0 3 2 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EWC48219.1 - 2.5e-56 190.6 0.1 6.7e-56 189.2 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EWC48219.1 - 3.2e-49 166.9 18.2 3.2e-49 166.9 18.2 4.6 4 1 0 4 4 4 1 Domain of unknown function (DUF3381) Acetyltransf_6 PF13480.7 EWC48219.1 - 1.5 8.9 4.8 3.3 7.9 2.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain CBP_BcsG PF11658.8 EWC48219.1 - 3.4 6.0 9.4 1.7 7.0 1.6 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG JAB PF01398.21 EWC48220.1 - 1.4e-31 108.9 0.1 4.9e-31 107.1 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EWC48220.1 - 3.4e-24 85.6 0.1 7.1e-24 84.5 0.1 1.6 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EWC48220.1 - 1e-05 25.3 0.0 6.3e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EWC48220.1 - 0.0011 19.1 0.0 0.0034 17.5 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0172) MAP65_ASE1 PF03999.12 EWC48221.1 - 9.5e-76 255.8 29.7 1.9e-75 254.8 29.7 1.5 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DUF5339 PF17274.2 EWC48221.1 - 0.009 16.9 0.6 0.032 15.1 0.6 2.0 1 0 0 1 1 1 1 Family of unknown function (DUF5339) Baculo_p24 PF05073.12 EWC48221.1 - 0.013 15.3 8.5 0.27 11.0 0.3 3.4 3 0 0 3 3 3 0 Baculovirus P24 capsid protein DUF2489 PF10675.9 EWC48221.1 - 0.055 13.4 0.1 0.055 13.4 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2489) Baculo_PEP_C PF04513.12 EWC48221.1 - 1.5 8.9 4.0 6.8 6.7 0.3 3.3 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HD_3 PF13023.6 EWC48221.1 - 9.2 6.2 11.1 0.45 10.4 2.5 2.9 4 0 0 4 4 4 0 HD domain DNA_ligase_A_M PF01068.21 EWC48222.1 - 6.3e-50 169.7 0.1 2e-49 168.0 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EWC48222.1 - 3.4e-39 134.9 0.0 9.1e-39 133.5 0.0 1.8 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EWC48222.1 - 5.8e-19 68.5 0.0 1.9e-18 66.9 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.5 EWC48222.1 - 4.8e-16 58.9 0.0 4.5e-12 46.2 0.0 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 EWC48222.1 - 1e-14 55.2 0.0 5.1e-14 52.9 0.0 2.2 2 0 0 2 2 2 1 RNA ligase BRCT PF00533.26 EWC48222.1 - 2.2e-06 28.0 0.1 7.4e-06 26.3 0.1 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EWC48222.1 - 0.0023 18.2 0.0 1.4 9.3 0.0 2.5 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain DNA_ligase_IV PF11411.8 EWC48222.1 - 0.0067 16.5 0.3 0.023 14.8 0.3 1.9 1 0 0 1 1 1 1 DNA ligase IV Clathrin PF00637.20 EWC48223.1 - 5.7e-23 81.4 0.1 8.5e-21 74.3 0.0 2.4 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_UBOX PF13445.6 EWC48223.1 - 4.7e-06 26.5 0.7 1.1e-05 25.3 0.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EWC48223.1 - 8.9e-05 22.2 2.0 0.00017 21.2 2.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EWC48223.1 - 0.00052 20.3 0.4 0.0011 19.2 0.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC48223.1 - 0.0033 17.3 0.3 0.0075 16.1 0.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC48223.1 - 0.0067 16.4 0.7 0.013 15.4 0.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EWC48223.1 - 0.007 16.2 0.3 0.015 15.1 0.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EWC48223.1 - 0.015 15.6 1.0 0.049 13.9 1.0 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain Vps39_1 PF10366.9 EWC48223.1 - 0.036 14.3 0.2 0.34 11.2 0.0 2.3 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 PHD PF00628.29 EWC48223.1 - 0.24 11.3 0.2 0.49 10.3 0.2 1.5 1 0 0 1 1 1 0 PHD-finger ANAPC1 PF12859.7 EWC48224.1 - 3e-13 50.5 0.6 1.6e-09 38.4 0.1 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EWC48224.1 - 0.0025 18.1 0.2 0.054 14.0 0.0 3.0 3 0 0 3 3 3 1 Proteasome/cyclosome repeat Ribosomal_S26e PF01283.19 EWC48225.1 - 4.6e-47 158.9 9.3 4.7e-46 155.7 9.3 1.9 1 1 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EWC48225.1 - 0.032 14.2 0.4 0.093 12.7 0.0 2.0 2 0 0 2 2 2 0 Zinc binding domain DUF1918 PF08940.11 EWC48225.1 - 0.077 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) DUF4668 PF15701.5 EWC48225.1 - 0.094 12.5 0.3 0.14 12.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) CBS PF00571.28 EWC48226.1 - 4.6e-33 113.4 8.4 4.5e-09 36.6 0.0 5.9 6 0 0 6 6 6 4 CBS domain PB1 PF00564.24 EWC48226.1 - 5.9e-10 38.9 1.1 1.2e-09 38.0 0.0 2.2 2 1 0 2 2 2 1 PB1 domain Importin_rep_4 PF18808.1 EWC48227.1 - 1.1e-35 121.7 4.6 3.6e-35 120.1 1.1 3.5 3 0 0 3 3 3 1 Importin repeat HEAT_EZ PF13513.6 EWC48227.1 - 5.3e-23 81.1 11.1 1.2e-08 35.3 0.1 8.1 7 1 1 8 8 7 4 HEAT-like repeat Importin_rep_5 PF18816.1 EWC48227.1 - 1.2e-21 76.8 0.1 5.3e-21 74.7 0.1 2.3 1 0 0 1 1 1 1 Importin repeat HEAT PF02985.22 EWC48227.1 - 3.9e-19 67.1 9.6 0.047 14.0 0.0 11.9 12 0 0 12 12 10 2 HEAT repeat HEAT_2 PF13646.6 EWC48227.1 - 2.8e-18 66.1 12.6 0.00059 20.2 0.0 8.6 4 3 6 10 10 10 7 HEAT repeats Importin_rep_6 PF18829.1 EWC48227.1 - 1.7e-11 44.2 0.1 1.7e-11 44.2 0.1 2.8 3 0 0 3 3 3 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 EWC48227.1 - 2.8e-09 37.5 0.6 0.35 11.5 0.0 7.0 3 3 5 8 8 8 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EWC48227.1 - 4.3e-09 36.0 0.5 2e-05 23.9 0.1 4.4 4 1 1 5 5 5 1 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 EWC48227.1 - 5.7e-08 32.8 0.0 0.0077 16.2 0.0 6.3 7 1 1 8 8 8 1 Domain of unknown function (DUF3385) Arm PF00514.23 EWC48227.1 - 7.7e-07 28.9 0.4 0.13 12.3 0.1 4.8 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat TFCD_C PF12612.8 EWC48227.1 - 2.7e-06 27.4 0.1 0.054 13.3 0.0 5.4 4 3 2 6 6 6 1 Tubulin folding cofactor D C terminal Cnd1 PF12717.7 EWC48227.1 - 9.8e-06 25.7 0.3 0.89 9.6 0.0 4.0 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 DRIM PF07539.12 EWC48227.1 - 1.2e-05 23.9 0.2 0.013 13.8 0.3 3.1 2 1 1 3 3 3 2 Down-regulated in metastasis RIX1 PF08167.12 EWC48227.1 - 3e-05 23.9 0.3 0.0054 16.5 0.0 3.6 2 1 2 4 4 4 2 rRNA processing/ribosome biogenesis Xpo1 PF08389.12 EWC48227.1 - 4.6e-05 23.5 0.0 0.011 15.7 0.0 3.8 3 0 0 3 3 3 1 Exportin 1-like protein Adaptin_N PF01602.20 EWC48227.1 - 0.00015 20.5 0.8 0.051 12.1 0.0 3.8 3 1 0 4 4 4 1 Adaptin N terminal region CLASP_N PF12348.8 EWC48227.1 - 0.00036 20.2 0.7 0.012 15.2 0.1 3.8 3 1 0 3 3 3 1 CLASP N terminal IFRD PF05004.13 EWC48227.1 - 0.00057 19.1 0.4 0.051 12.7 0.4 3.5 3 1 0 3 3 3 1 Interferon-related developmental regulator (IFRD) RTP1_C1 PF10363.9 EWC48227.1 - 0.0037 17.4 0.3 0.29 11.3 0.2 3.9 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 UNC45-central PF11701.8 EWC48227.1 - 0.0092 16.0 3.0 3.2 7.7 0.2 3.7 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central Ribonuc_2-5A PF06479.12 EWC48227.1 - 0.13 12.5 0.1 0.71 10.1 0.0 2.2 2 0 0 2 2 2 0 Ribonuclease 2-5A DUF4598 PF15370.6 EWC48228.1 - 2.5e-12 47.3 11.7 2.1e-09 37.9 11.7 3.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4598) Rhomboid PF01694.22 EWC48228.1 - 4e-07 30.1 10.9 6.8e-07 29.4 10.9 1.2 1 0 0 1 1 1 1 Rhomboid family CDC45 PF02724.14 EWC48228.1 - 6.2 5.0 5.4 9 4.4 5.4 1.2 1 0 0 1 1 1 0 CDC45-like protein NIF PF03031.18 EWC48229.1 - 1.3e-22 80.3 0.0 2.6e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EWC48229.1 - 4.8e-08 33.3 0.0 1.5e-07 31.7 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EWC48229.1 - 3e-05 23.9 0.1 7.8e-05 22.5 0.1 1.7 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EWC48229.1 - 0.00017 21.9 0.2 0.004 17.5 0.0 3.1 4 0 0 4 4 4 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EWC48229.1 - 0.0008 19.7 0.1 0.002 18.4 0.1 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain Folliculin PF11704.8 EWC48230.1 - 9.6e-46 156.0 0.5 9.3e-45 152.8 0.0 2.2 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4770 PF15994.5 EWC48230.1 - 0.15 12.3 2.7 0.28 11.4 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) SR-25 PF10500.9 EWC48230.1 - 9.2 5.8 13.5 18 4.8 13.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CLP1_P PF16575.5 EWC48231.1 - 1.8e-34 119.2 0.0 2.7e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EWC48231.1 - 0.0029 18.0 0.0 0.015 15.7 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EWC48231.1 - 0.011 15.0 0.1 0.027 13.8 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin MMR_HSR1 PF01926.23 EWC48231.1 - 0.11 12.6 0.1 0.25 11.5 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EWC48231.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_polI_A34 PF08208.11 EWC48232.1 - 1.7e-33 116.5 22.2 1.7e-33 116.5 22.2 3.3 2 1 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 Prefoldin_2 PF01920.20 EWC48233.1 - 1.1e-21 76.7 12.0 1.1e-21 76.7 12.0 1.8 1 1 1 2 2 2 1 Prefoldin subunit Rh5 PF18515.1 EWC48233.1 - 1.4e-05 24.5 5.3 1.6e-05 24.3 5.3 1.1 1 0 0 1 1 1 1 Rh5 coiled-coil domain Prefoldin_3 PF13758.6 EWC48233.1 - 0.0056 16.7 3.5 0.0056 16.7 3.5 1.8 1 1 1 2 2 2 1 Prefoldin subunit DUF1319 PF07028.11 EWC48233.1 - 0.006 16.8 1.8 0.006 16.8 1.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1319) YabA PF06156.13 EWC48233.1 - 0.023 15.4 8.3 1.9 9.1 5.6 2.1 2 0 0 2 2 2 0 Initiation control protein YabA DUF812 PF05667.11 EWC48233.1 - 0.028 13.3 11.8 0.032 13.1 11.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ERM PF00769.19 EWC48233.1 - 0.04 13.7 12.1 0.06 13.1 12.1 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Spc7 PF08317.11 EWC48233.1 - 0.1 11.4 13.2 0.14 11.1 13.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein NPV_P10 PF05531.12 EWC48233.1 - 0.54 10.8 9.1 4.2 7.9 0.9 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 EWC48233.1 - 0.99 9.9 18.0 0.27 11.7 11.7 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 Prefoldin PF02996.17 EWC48233.1 - 1 9.3 15.3 0.12 12.3 8.3 2.3 2 1 0 2 2 2 0 Prefoldin subunit Spc24 PF08286.11 EWC48233.1 - 1.3 9.3 16.3 2.2 8.6 1.7 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4407 PF14362.6 EWC48233.1 - 1.3 8.3 11.4 1.8 7.9 11.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 EWC48233.1 - 1.6 9.2 20.5 7.5 7.1 13.7 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Helo_like_N PF17111.5 EWC48233.1 - 4.4 6.6 11.2 4.6 6.6 5.7 2.0 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins AAA PF00004.29 EWC48234.1 - 1.2e-42 145.5 0.0 2e-42 144.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 EWC48234.1 - 6.8e-24 83.7 4.6 1.8e-23 82.3 4.6 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Vps4_C PF09336.10 EWC48234.1 - 2.5e-06 27.4 0.4 1.1e-05 25.3 0.1 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_16 PF13191.6 EWC48234.1 - 1e-05 26.0 0.2 0.00022 21.7 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EWC48234.1 - 3.5e-05 23.6 0.0 5.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EWC48234.1 - 6.1e-05 23.4 0.1 0.0093 16.3 0.0 3.1 3 0 0 3 3 3 1 RNA helicase IstB_IS21 PF01695.17 EWC48234.1 - 7.4e-05 22.5 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EWC48234.1 - 0.0001 21.7 0.0 0.00017 20.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 EWC48234.1 - 0.00012 22.1 0.0 0.00035 20.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EWC48234.1 - 0.00015 21.9 0.0 0.018 15.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EWC48234.1 - 0.00017 21.8 0.0 0.0025 18.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EWC48234.1 - 0.00019 21.8 0.1 0.0064 16.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EWC48234.1 - 0.00023 20.4 0.0 0.00077 18.7 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EWC48234.1 - 0.00058 20.4 0.0 0.0012 19.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EWC48234.1 - 0.001 19.1 0.0 0.0025 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EWC48234.1 - 0.0016 18.2 0.0 0.0089 15.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 EWC48234.1 - 0.0039 17.0 0.0 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_25 PF13481.6 EWC48234.1 - 0.0049 16.5 0.4 0.64 9.6 0.1 2.5 2 1 1 3 3 2 1 AAA domain Torsin PF06309.11 EWC48234.1 - 0.0068 16.5 0.0 0.069 13.2 0.0 2.1 2 0 0 2 2 2 1 Torsin AAA_17 PF13207.6 EWC48234.1 - 0.011 16.1 0.0 0.035 14.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EWC48234.1 - 0.017 14.7 0.1 0.066 12.7 0.0 2.0 2 1 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EWC48234.1 - 0.025 13.9 0.0 0.074 12.4 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EWC48234.1 - 0.054 13.4 0.0 0.67 9.9 0.0 2.2 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.16 EWC48234.1 - 0.063 12.7 0.6 0.14 11.5 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein Parvo_NS1 PF01057.17 EWC48234.1 - 0.073 12.1 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EWC48234.1 - 0.11 11.8 0.1 1.4 8.2 0.1 2.5 1 1 1 2 2 2 0 Zeta toxin USP8_dimer PF08969.11 EWC48234.1 - 0.13 12.5 2.7 0.28 11.4 2.7 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain ATPase PF06745.13 EWC48234.1 - 0.13 11.6 0.0 7.9 5.8 0.0 2.4 1 1 1 2 2 2 0 KaiC ATPase_2 PF01637.18 EWC48234.1 - 0.28 11.1 1.4 1.6 8.6 0.0 2.4 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea CoA_trans PF01144.23 EWC48235.1 - 1.1e-100 335.6 3.3 3e-66 222.9 0.3 2.1 2 0 0 2 2 2 2 Coenzyme A transferase Glyoxalase_6 PF18029.1 EWC48236.1 - 0.0064 17.3 0.0 0.0084 16.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Gaa1 PF04114.14 EWC48237.1 - 6.3e-170 566.4 0.3 7.6e-170 566.2 0.3 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component zf-C2H2_jaz PF12171.8 EWC48238.1 - 3e-05 24.2 1.2 3e-05 24.2 1.2 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EWC48238.1 - 0.0095 16.3 0.2 0.013 15.8 0.2 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Aconitase PF00330.20 EWC48239.1 - 8.4e-150 499.8 0.0 1e-149 499.5 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EWC48239.1 - 2.4e-45 154.0 0.0 4.7e-45 153.1 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain CRAL_TRIO PF00650.20 EWC48240.1 - 3.8e-34 117.7 0.1 8.2e-26 90.6 0.0 2.4 1 1 1 2 2 2 2 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EWC48240.1 - 2e-14 53.5 0.7 6.1e-14 51.9 0.1 2.2 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EWC48240.1 - 0.00039 20.6 0.0 0.00091 19.4 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CSN5_C PF18323.1 EWC48241.1 - 0.02 15.8 0.6 0.059 14.3 0.0 2.0 3 0 0 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain Cob_adeno_trans PF01923.18 EWC48241.1 - 0.022 14.9 0.6 0.026 14.7 0.6 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF1394 PF07159.12 EWC48241.1 - 0.033 13.4 0.2 0.042 13.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1394) Cytochrom_B562 PF07361.11 EWC48241.1 - 0.17 12.5 1.3 0.28 11.9 1.3 1.3 1 0 0 1 1 1 0 Cytochrome b562 Prominin PF05478.11 EWC48241.1 - 0.32 8.9 0.1 0.37 8.7 0.1 1.1 1 0 0 1 1 1 0 Prominin NPV_P10 PF05531.12 EWC48241.1 - 0.4 11.2 2.5 0.52 10.8 0.8 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Rsa3 PF14615.6 EWC48242.1 - 2.3e-18 65.5 0.1 3.5e-18 64.9 0.1 1.3 1 0 0 1 1 1 1 Ribosome-assembly protein 3 DUF4766 PF15973.5 EWC48242.1 - 0.17 12.5 3.5 0.34 11.5 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4766) PBP1_TM PF14812.6 EWC48242.1 - 0.58 10.6 22.4 0.48 10.8 5.7 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SR-25 PF10500.9 EWC48242.1 - 0.75 9.4 63.5 0.071 12.7 34.5 2.9 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein LAP1C PF05609.12 EWC48242.1 - 4.9 6.1 25.0 6 5.8 25.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nop14 PF04147.12 EWC48242.1 - 5.5 5.1 29.2 7.6 4.6 29.2 1.2 1 0 0 1 1 1 0 Nop14-like family Glyco_hydro_72 PF03198.14 EWC48243.1 - 1.1e-131 438.8 0.7 1.5e-131 438.4 0.7 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EWC48243.1 - 5.7e-21 75.0 5.4 1.6e-20 73.5 4.5 2.3 2 0 0 2 2 2 1 X8 domain Cellulase PF00150.18 EWC48243.1 - 0.00056 19.4 0.4 0.014 14.8 0.4 2.3 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) BsuBI_PstI_RE_N PF17728.1 EWC48243.1 - 0.056 13.3 0.0 1.8 8.4 0.0 2.2 1 1 1 2 2 2 0 BsuBI/PstI restriction endonuclease HTH domain Glucan_synthase PF02364.15 EWC48244.1 - 0 1374.4 0.0 0 1373.9 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EWC48244.1 - 1.3e-44 151.6 0.7 4e-44 150.1 0.7 1.9 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Wbp11 PF09429.10 EWC48244.1 - 0.035 14.5 5.9 0.078 13.4 3.1 2.3 2 0 0 2 2 2 0 WW domain binding protein 11 SGT1 PF07093.11 EWC48246.1 - 1e-103 347.8 10.6 1.5e-98 330.8 0.0 2.1 2 0 0 2 2 2 2 SGT1 protein MFS_1 PF07690.16 EWC48247.1 - 1.3e-22 80.2 36.3 1.6e-11 43.7 18.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 EWC48247.1 - 0.00011 21.0 10.9 0.16 10.5 0.0 3.4 2 1 1 3 3 3 3 Vacuole effluxer Atg22 like MFS_1_like PF12832.7 EWC48247.1 - 0.00018 20.5 12.2 0.0069 15.3 9.5 2.1 1 1 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 EWC48247.1 - 0.0046 15.9 15.7 0.0074 15.2 7.7 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 EWC48247.1 - 0.0079 14.5 9.9 0.0086 14.4 1.6 2.9 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family UNC-93 PF05978.16 EWC48247.1 - 0.34 10.6 4.3 0.57 9.9 1.6 2.4 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 Bromodomain PF00439.25 EWC48248.1 - 1.1e-17 63.8 0.3 2.8e-17 62.5 0.3 1.6 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 EWC48248.1 - 1.1e-07 31.8 0.0 2.6e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated PBP1_TM PF14812.6 EWC48248.1 - 7.8 6.9 10.4 13 6.2 0.7 3.9 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GRAM PF02893.20 EWC48249.1 - 2.8e-33 114.2 0.8 1.3e-21 76.6 0.0 3.5 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 EWC48249.1 - 3.4e-29 101.7 0.0 7.6e-29 100.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 EWC48249.1 - 1.1e-13 51.6 0.1 2.1e-12 47.4 0.0 2.7 3 0 0 3 3 3 1 PH domain UDPGT PF00201.18 EWC48249.1 - 2.2e-05 23.4 0.0 8.8e-05 21.5 0.0 1.9 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_8 PF15409.6 EWC48249.1 - 0.0018 18.5 0.1 0.0049 17.1 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EWC48249.1 - 0.0022 18.3 0.0 0.015 15.5 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain Mog1 PF04603.12 EWC48250.1 - 5.9e-34 117.4 0.0 7.3e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein SnoaL PF07366.12 EWC48251.1 - 3.8e-20 72.0 0.0 4.3e-20 71.8 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EWC48251.1 - 4.4e-10 40.1 0.0 5.7e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SprT-like PF10263.9 EWC48252.1 - 4.1e-17 62.1 0.0 1e-16 60.8 0.0 1.7 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 EWC48252.1 - 0.003 17.4 4.7 0.0068 16.3 4.7 1.7 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EWC48252.1 - 0.032 14.4 1.6 0.1 12.8 1.6 1.9 1 0 0 1 1 1 0 Zinc ribbon domain SAWADEE PF16719.5 EWC48252.1 - 0.055 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 SAWADEE domain HMG_box PF00505.19 EWC48252.1 - 0.094 13.1 0.0 0.3 11.5 0.0 1.9 1 0 0 1 1 1 0 HMG (high mobility group) box DUF2268 PF10026.9 EWC48252.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) TPR_2 PF07719.17 EWC48253.1 - 1.3e-32 109.2 27.3 0.00041 20.2 0.0 17.4 18 0 0 18 18 17 6 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48253.1 - 1.6e-30 105.4 27.7 1.5e-05 25.4 0.0 13.3 12 2 2 14 14 14 6 Tetratricopeptide repeat TPR_1 PF00515.28 EWC48253.1 - 1.6e-29 100.5 13.5 8e-05 22.3 0.0 13.9 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_17 PF13431.6 EWC48253.1 - 5.2e-28 95.4 7.9 0.0075 16.6 0.0 12.1 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_14 PF13428.6 EWC48253.1 - 5.4e-28 95.3 27.9 0.034 15.0 0.0 17.7 11 6 9 20 20 18 6 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48253.1 - 5.4e-26 91.0 37.6 4.3e-06 27.3 0.0 12.6 9 3 4 13 13 13 7 Tetratricopeptide repeat TPR_8 PF13181.6 EWC48253.1 - 1.9e-21 74.4 23.2 5.4e-05 23.1 0.0 15.0 20 0 0 20 20 15 4 Tetratricopeptide repeat TPR_11 PF13414.6 EWC48253.1 - 3.1e-20 71.6 20.1 7.6e-05 22.3 0.0 12.4 12 1 1 13 13 13 3 TPR repeat TPR_12 PF13424.6 EWC48253.1 - 2.6e-14 53.2 36.0 0.029 14.6 1.7 12.4 10 3 2 12 12 12 4 Tetratricopeptide repeat TPR_9 PF13371.6 EWC48253.1 - 1e-12 48.0 4.4 0.025 14.7 0.0 8.3 5 3 2 8 8 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 EWC48253.1 - 3.9e-12 46.0 20.8 13 6.7 0.0 15.0 19 0 0 19 19 15 0 Tetratricopeptide repeat TPR_7 PF13176.6 EWC48253.1 - 2e-08 33.7 10.6 0.072 13.1 0.0 10.4 12 0 0 12 12 10 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC48253.1 - 2.2e-05 24.6 13.8 0.037 14.2 0.0 7.7 7 3 1 8 8 8 1 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 EWC48253.1 - 2.9e-05 23.3 3.9 1.4 7.8 0.0 5.2 5 1 0 5 5 5 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_22 PF18833.1 EWC48253.1 - 0.00051 20.1 0.1 0.0019 18.3 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TAtT PF16811.5 EWC48253.1 - 0.00053 19.4 0.4 0.73 9.1 0.0 3.0 2 1 0 2 2 2 2 TRAP transporter T-component TPR_20 PF14561.6 EWC48253.1 - 0.0028 18.0 12.4 1.8 9.0 0.0 7.3 6 2 0 7 7 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EWC48253.1 - 0.0077 16.1 13.2 13 5.8 0.1 7.3 7 1 1 8 8 7 0 Tetratricopeptide repeat DUF4093 PF13331.6 EWC48253.1 - 0.12 12.8 0.3 3.1 8.3 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4093) TetR_C_15 PF17918.1 EWC48253.1 - 0.54 11.0 3.6 1.3e+02 3.4 0.3 4.5 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RPN7 PF10602.9 EWC48253.1 - 0.73 9.5 3.0 11 5.7 0.3 3.8 4 0 0 4 4 4 0 26S proteasome subunit RPN7 SNAP PF14938.6 EWC48253.1 - 5.2 6.4 10.1 2.2 7.6 3.7 3.4 3 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP 2-Hacid_dh_C PF02826.19 EWC48254.1 - 5.1e-49 166.0 0.0 8.1e-49 165.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EWC48254.1 - 6.3e-16 58.2 0.0 1.1e-15 57.5 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EWC48254.1 - 0.00082 19.6 0.0 0.0021 18.3 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EWC48254.1 - 0.0054 16.1 0.2 0.19 11.0 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EWC48255.1 - 9.2e-25 87.2 0.0 9e-22 77.5 0.0 2.6 2 1 1 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48255.1 - 1.3e-18 67.4 0.0 2.6e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Elong_Iki1 PF10483.9 EWC48256.1 - 1.6e-85 287.2 0.0 2e-85 286.9 0.0 1.1 1 0 0 1 1 1 1 Elongator subunit Iki1 CLPTM1 PF05602.12 EWC48257.1 - 1.9e-143 478.6 3.5 2.4e-143 478.2 3.5 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) 2TM PF13239.6 EWC48257.1 - 0.073 13.4 3.0 0.73 10.2 0.3 3.1 2 0 0 2 2 2 0 2TM domain Ras PF00071.22 EWC48258.1 - 8.4e-49 165.3 0.4 9.6e-49 165.1 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC48258.1 - 5.6e-15 55.6 0.1 8e-15 55.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EWC48258.1 - 8.8e-05 22.6 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EWC48258.1 - 0.00026 20.5 0.1 0.00031 20.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EWC48258.1 - 0.00029 20.3 0.1 0.00052 19.5 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EWC48258.1 - 0.0012 18.4 0.1 0.02 14.4 0.1 2.3 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EWC48258.1 - 0.0023 17.8 0.1 1.8 8.4 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EWC48258.1 - 0.0033 17.0 0.1 0.032 13.8 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_14 PF13173.6 EWC48258.1 - 0.0092 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1_Xtn PF16897.5 EWC48258.1 - 0.023 14.7 0.0 0.042 13.8 0.0 1.4 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain ATPase_2 PF01637.18 EWC48258.1 - 0.1 12.5 0.4 0.22 11.4 0.4 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea G10 PF01125.17 EWC48259.1 - 3.6e-65 218.2 3.1 4.1e-65 218.0 3.1 1.0 1 0 0 1 1 1 1 G10 protein Fes1 PF08609.10 EWC48260.1 - 1.2e-22 80.6 0.9 1.2e-22 80.6 0.9 1.9 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_EZ PF13513.6 EWC48260.1 - 6.5e-06 26.5 0.0 5.1e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 HEAT-like repeat HEAT PF02985.22 EWC48260.1 - 8.6e-06 25.6 0.0 0.25 11.7 0.0 3.4 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 EWC48260.1 - 0.00031 21.1 0.0 0.0031 17.9 0.0 2.0 1 1 0 1 1 1 1 HEAT repeats Arm PF00514.23 EWC48260.1 - 0.00088 19.2 0.1 0.0099 15.9 0.0 2.6 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Uso1_p115_head PF04869.14 EWC48260.1 - 0.0009 18.5 0.2 0.0019 17.4 0.1 1.6 1 1 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region V-ATPase_H_C PF11698.8 EWC48260.1 - 0.0025 17.9 0.8 0.0089 16.1 0.2 2.0 2 0 0 2 2 2 1 V-ATPase subunit H RICTOR_V PF14668.6 EWC48260.1 - 0.036 14.3 0.0 0.072 13.3 0.0 1.4 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 Bmt2 PF11968.8 EWC48261.1 - 4.5e-65 219.6 0.0 2.8e-40 138.5 0.0 2.2 2 0 0 2 2 2 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 EWC48261.1 - 0.00031 20.6 0.0 0.00064 19.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain K-cyclin_vir_C PF09080.10 EWC48261.1 - 0.12 12.8 0.1 0.3 11.5 0.1 1.6 2 0 0 2 2 2 0 K cyclin, C terminal Methyltransf_12 PF08242.12 EWC48261.1 - 0.17 12.6 0.0 0.39 11.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PBD PF00786.28 EWC48262.1 - 2.1e-13 50.4 0.0 3.7e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Pheromone PF08015.11 EWC48262.1 - 0.042 14.9 2.8 0.042 14.9 2.8 1.8 2 1 0 2 2 2 0 Fungal mating-type pheromone Forkhead PF00250.18 EWC48263.1 - 1.5e-34 118.1 0.1 3.2e-34 117.0 0.1 1.6 1 0 0 1 1 1 1 Forkhead domain SPC12 PF06645.13 EWC48264.1 - 1.2e-26 92.6 0.4 1.6e-26 92.1 0.4 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) LANC_like PF05147.13 EWC48264.1 - 0.15 10.6 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein Pkinase PF00069.25 EWC48265.1 - 2.3e-65 220.6 0.0 2.7e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48265.1 - 2.9e-31 108.7 0.0 3.9e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC48265.1 - 1.1e-06 28.2 0.0 2.3e-05 23.9 0.0 2.1 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EWC48265.1 - 0.00061 19.2 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EWC48265.1 - 0.0033 16.3 0.0 0.0047 15.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EWC48265.1 - 0.0076 15.9 0.1 1.9 8.0 0.1 2.1 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 WAPL PF07814.13 EWC48266.1 - 5.4e-13 48.5 0.7 1.5e-08 33.9 0.0 2.3 2 0 0 2 2 2 2 Wings apart-like protein regulation of heterochromatin Elf1 PF05129.13 EWC48267.1 - 0.0055 16.7 0.1 0.0092 16.0 0.1 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like UPRTase PF14681.6 EWC48268.1 - 3.1e-82 275.0 0.0 3.6e-82 274.8 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EWC48268.1 - 0.0055 16.2 0.0 0.0084 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CoA_binding_2 PF13380.6 EWC48268.1 - 0.06 13.9 0.0 0.23 11.9 0.0 1.8 2 0 0 2 2 2 0 CoA binding domain Flu_C_NS1 PF03506.13 EWC48268.1 - 0.16 11.9 0.1 0.25 11.3 0.1 1.2 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) GTP_CH_N PF12471.8 EWC48269.1 - 8.4e-89 296.4 0.0 1.3e-88 295.8 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EWC48269.1 - 4.3e-17 62.2 0.0 6.7e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II SlyX PF04102.12 EWC48269.1 - 0.12 13.0 0.4 0.26 11.9 0.4 1.6 1 0 0 1 1 1 0 SlyX FlaC_arch PF05377.11 EWC48269.1 - 0.17 12.3 0.2 0.42 11.0 0.2 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Ax_dynein_light PF10211.9 EWC48271.1 - 0.27 11.1 4.9 0.36 10.7 3.6 1.8 2 0 0 2 2 2 0 Axonemal dynein light chain YabA PF06156.13 EWC48271.1 - 1.4 9.6 7.5 1.8 9.2 4.4 2.6 2 1 0 2 2 2 0 Initiation control protein YabA PRKG1_interact PF15898.5 EWC48271.1 - 2.6 9.0 9.8 0.56 11.1 0.9 3.1 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF4201 PF13870.6 EWC48271.1 - 4.3 7.0 11.1 0.12 12.0 4.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) ZapB PF06005.12 EWC48271.1 - 6.5 7.3 12.7 1.3 9.5 1.8 3.0 3 0 0 3 3 3 0 Cell division protein ZapB Geminin PF07412.12 EWC48271.1 - 8 6.2 9.5 1.1 9.0 5.1 1.8 2 0 0 2 2 2 0 Geminin Ribosomal_S3Ae PF01015.18 EWC48272.1 - 3.1e-89 297.9 3.6 3.8e-89 297.6 3.6 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 EWC48272.1 - 0.013 16.0 0.6 0.067 13.7 0.1 2.2 2 0 0 2 2 2 0 Translation initiation factor SUI1 zf-rbx1 PF12678.7 EWC48273.1 - 3.1e-25 88.2 13.1 4.1e-25 87.8 13.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EWC48273.1 - 9.4e-17 60.9 9.9 1.2e-16 60.5 9.9 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EWC48273.1 - 2.4e-06 27.8 14.6 8.6e-05 22.8 14.6 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EWC48273.1 - 9.3e-05 22.2 3.5 9.3e-05 22.2 3.5 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC48273.1 - 0.0015 18.4 11.8 0.025 14.4 11.8 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC48273.1 - 0.18 11.7 10.9 0.55 10.1 4.6 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EWC48273.1 - 0.32 10.8 15.9 29 4.5 15.9 2.5 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 EWC48273.1 - 0.46 10.6 7.7 1.6 8.8 7.7 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 EWC48273.1 - 0.56 10.4 9.4 2.9 8.1 9.6 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EWC48273.1 - 0.63 9.7 14.9 0.15 11.7 4.8 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type PNRC PF15365.6 EWC48274.1 - 1.2e-08 34.5 2.8 1.2e-08 34.5 2.8 2.8 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif MaoC_dehydratas PF01575.19 EWC48275.1 - 0.018 14.6 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 MaoC like domain TFIIA PF03153.13 EWC48275.1 - 1.2 9.1 17.3 2.1 8.3 17.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Phosphodiest PF01663.22 EWC48276.1 - 1.6e-12 47.7 2.8 2.1e-08 34.2 0.2 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EWC48276.1 - 5.4e-06 26.0 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EWC48276.1 - 0.0047 16.3 0.0 0.008 15.6 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF3384 PF11864.8 EWC48277.1 - 2.3e-128 429.1 5.7 2.3e-128 429.1 5.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EWC48277.1 - 1.3e-55 187.9 0.1 2.3e-55 187.1 0.1 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EWC48277.1 - 2.6e-36 125.5 0.9 4.5e-31 108.3 1.2 3.5 3 0 0 3 3 3 2 Tuberin Thoc2 PF11732.8 EWC48277.1 - 0.086 12.9 1.0 0.23 11.5 0.1 2.2 2 0 0 2 2 2 0 Transcription- and export-related complex subunit Aa_trans PF01490.18 EWC48278.1 - 3.2e-60 204.0 30.9 3.7e-60 203.8 30.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MerC PF03203.14 EWC48278.1 - 0.018 15.5 3.7 0.018 15.5 3.7 2.8 2 1 0 2 2 2 0 MerC mercury resistance protein Thymidylat_synt PF00303.19 EWC48279.1 - 9.7e-110 365.9 0.0 1.1e-109 365.7 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase MnmE_helical PF12631.7 EWC48280.1 - 5.4e-26 92.0 0.5 6.7e-26 91.7 0.5 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 EWC48280.1 - 5.8e-22 78.2 0.0 2.3e-21 76.3 0.0 2.0 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EWC48280.1 - 9.4e-18 64.4 0.1 1.5e-17 63.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EWC48280.1 - 8.2e-06 25.4 0.4 0.00023 20.7 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EWC48280.1 - 0.00018 21.6 0.0 0.00033 20.7 0.0 1.6 1 0 0 1 1 1 1 Dynamin family MCM PF00493.23 EWC48280.1 - 0.0019 17.4 0.0 0.0038 16.4 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain GTP_EFTU PF00009.27 EWC48280.1 - 0.0046 16.5 0.3 0.23 11.0 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Glyco_hydro_3_C PF01915.22 EWC48280.1 - 0.0068 16.4 1.4 0.01 15.8 1.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain RsgA_GTPase PF03193.16 EWC48280.1 - 0.013 15.4 0.2 0.088 12.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 EWC48280.1 - 0.049 13.9 0.2 4.5 7.5 0.0 2.7 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 EWC48280.1 - 0.14 12.4 0.1 0.66 10.2 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EWC48280.1 - 0.15 11.4 0.1 0.27 10.5 0.1 1.4 1 0 0 1 1 1 0 AIG1 family RRM_1 PF00076.22 EWC48281.1 - 6.4e-32 109.2 0.0 2.6e-15 56.0 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EWC48281.1 - 0.00074 19.1 0.9 0.29 10.8 0.1 2.4 2 0 0 2 2 2 2 Ribonuclease B OB domain Cas_Cas2CT1978 PF09707.10 EWC48281.1 - 0.009 16.1 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 1 CRISPR-associated protein (Cas_Cas2CT1978) RRM_7 PF16367.5 EWC48281.1 - 0.011 15.9 0.0 0.14 12.3 0.0 2.2 2 1 0 2 2 2 0 RNA recognition motif Limkain-b1 PF11608.8 EWC48281.1 - 0.021 14.9 0.1 0.49 10.5 0.0 2.1 2 0 0 2 2 2 0 Limkain b1 Nup35_RRM_2 PF14605.6 EWC48281.1 - 0.037 14.0 0.0 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EWC48281.1 - 0.053 13.1 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC48281.1 - 0.063 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF4834 PF16118.5 EWC48282.1 - 2.6 9.1 12.4 0.15 13.1 6.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF913 PF06025.12 EWC48282.1 - 3.3 6.6 4.8 9.4 5.1 3.4 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) PBP_sp32 PF07222.12 EWC48282.1 - 3.4 7.1 13.7 5.2 6.5 13.7 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CPSF100_C PF13299.6 EWC48282.1 - 4 7.6 8.7 0.55 10.4 4.7 1.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 EWC48282.1 - 8.5 6.1 7.5 13 5.5 7.5 1.3 1 0 0 1 1 1 0 Connexin Cse1 PF08506.10 EWC48283.1 - 3.3e-160 532.9 4.9 4.8e-160 532.4 4.9 1.2 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 EWC48283.1 - 1.2e-147 492.0 0.0 3e-146 487.4 0.0 2.4 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 EWC48283.1 - 5.5e-13 48.6 0.0 2.7e-12 46.4 0.0 2.4 1 0 0 1 1 1 1 Importin-beta N-terminal domain DNTTIP1_dimer PF18192.1 EWC48283.1 - 0.025 14.9 0.8 0.65 10.4 0.1 3.0 2 1 0 2 2 2 0 DNTTIP1 dimerisation domain RIX1 PF08167.12 EWC48283.1 - 0.068 12.9 1.0 0.55 9.9 0.2 2.9 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Xpo1 PF08389.12 EWC48283.1 - 0.11 12.6 4.3 9.6 6.3 0.0 4.2 5 0 0 5 5 5 0 Exportin 1-like protein V-ATPase_H_N PF03224.14 EWC48283.1 - 0.19 11.0 2.3 2.5 7.3 0.1 2.6 1 1 1 2 2 2 0 V-ATPase subunit H PUF PF00806.19 EWC48284.1 - 3e-63 206.1 19.0 5.5e-09 35.2 0.0 8.6 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat Phosphodiest PF01663.22 EWC48286.1 - 1.8e-13 50.8 0.2 2.9e-13 50.2 0.2 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EWC48286.1 - 0.0018 17.8 0.0 0.0028 17.1 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EWC48286.1 - 0.0038 16.6 0.5 0.0067 15.8 0.5 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Form-deh_trans PF09163.11 EWC48286.1 - 0.68 9.7 5.8 1.5 8.7 0.1 3.6 3 0 0 3 3 3 0 Formate dehydrogenase N, transmembrane CorA PF01544.18 EWC48287.1 - 4.2e-42 144.5 0.0 6.4e-42 143.9 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Transcrip_reg PF01709.20 EWC48288.1 - 5.7e-36 124.2 0.0 6.9e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator HEAT PF02985.22 EWC48289.1 - 3.1e-09 36.3 14.3 0.16 12.3 0.0 10.5 10 0 0 10 10 10 3 HEAT repeat HEAT_2 PF13646.6 EWC48289.1 - 4e-06 27.1 4.6 1 9.8 0.0 6.9 5 2 1 7 7 7 3 HEAT repeats Cnd1 PF12717.7 EWC48289.1 - 0.00087 19.4 0.6 1.4 8.9 0.0 4.8 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EWC48289.1 - 0.0019 18.4 0.2 1.9 8.7 0.0 4.0 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 FH2 PF02181.23 EWC48290.1 - 1.1e-66 225.5 0.9 2.8e-66 224.2 0.9 1.7 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EWC48290.1 - 1.1e-54 184.9 0.5 6.3e-54 182.4 0.0 2.6 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EWC48290.1 - 3.3e-44 150.9 3.0 1.2e-43 149.0 0.0 3.2 3 1 1 4 4 4 1 Diaphanous FH3 Domain YfaZ PF07437.11 EWC48290.1 - 0.14 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 YfaZ precursor DivIC PF04977.15 EWC48290.1 - 2.6 7.9 5.9 1 9.2 1.2 2.7 2 0 0 2 2 2 0 Septum formation initiator SCNM1_acidic PF15805.5 EWC48291.1 - 3.1 7.6 7.5 1.7 8.4 2.0 2.6 2 1 0 2 2 2 0 Acidic C-terminal region of sodium channel modifier 1 SCNM1 Hus1 PF04005.12 EWC48292.1 - 2.6e-71 240.2 0.0 2.9e-71 240.0 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein PCNA_N PF00705.18 EWC48292.1 - 0.024 14.3 0.0 8.3 6.1 0.0 2.4 3 0 0 3 3 3 0 Proliferating cell nuclear antigen, N-terminal domain DUF3849 PF12960.7 EWC48292.1 - 0.034 14.1 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) MMM1 PF10296.9 EWC48293.1 - 4e-128 427.1 4.4 1.2e-125 419.0 4.4 2.9 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 APS_kinase PF01583.20 EWC48294.1 - 6.3e-68 227.6 0.0 8.4e-68 227.2 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EWC48294.1 - 1.2e-07 32.0 0.0 2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EWC48294.1 - 0.00015 22.3 0.0 0.00023 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 EWC48294.1 - 0.0011 18.8 0.2 0.013 15.4 0.2 2.3 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein KTI12 PF08433.10 EWC48294.1 - 0.0014 18.1 0.0 0.0014 18.1 0.0 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EWC48294.1 - 0.0028 18.0 0.0 0.0038 17.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EWC48294.1 - 0.0084 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF463 PF04317.12 EWC48294.1 - 0.031 13.2 0.0 0.037 13.0 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 Cytidylate_kin PF02224.18 EWC48294.1 - 0.035 13.8 0.0 3.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase Zeta_toxin PF06414.12 EWC48294.1 - 0.036 13.3 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin 6PF2K PF01591.18 EWC48294.1 - 0.18 11.1 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase UPF0220 PF05255.11 EWC48295.1 - 3.1e-69 231.8 3.0 3.4e-69 231.6 3.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) SNRNP27 PF08648.12 EWC48296.1 - 1.8e-26 91.9 0.2 1.8e-26 91.9 0.2 1.7 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins DUF936 PF06075.12 EWC48296.1 - 3.2 6.6 11.4 4.7 6.0 11.4 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Glyco_hydro_63 PF03200.16 EWC48297.1 - 4.1e-169 563.4 0.1 9.6e-168 558.9 0.1 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EWC48297.1 - 1.9e-73 247.3 0.0 3.8e-73 246.3 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EWC48297.1 - 2.5e-06 26.6 0.0 4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 EWC48297.1 - 0.052 12.5 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase MMtag PF10159.9 EWC48298.1 - 5.5e-30 103.5 3.0 5.5e-30 103.5 3.0 2.3 2 1 0 2 2 2 1 Multiple myeloma tumor-associated Histone PF00125.24 EWC48299.1 - 4.2e-43 146.9 0.8 5.3e-43 146.5 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EWC48299.1 - 0.00027 21.0 0.1 0.00046 20.3 0.1 1.4 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EWC48299.1 - 0.00046 20.4 0.6 0.00082 19.6 0.5 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EWC48299.1 - 0.00092 19.6 0.2 0.0015 18.8 0.2 1.4 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EWC48299.1 - 0.017 15.2 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit MIF4G_like PF09088.11 EWC48300.1 - 1.6e-84 282.4 0.0 2.4e-84 281.8 0.0 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EWC48300.1 - 8.6e-70 235.2 0.0 1.2e-69 234.8 0.0 1.2 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 EWC48300.1 - 0.00022 20.9 0.0 0.00056 19.6 0.0 1.6 1 0 0 1 1 1 1 MIF4G domain adh_short PF00106.25 EWC48301.1 - 6e-32 110.7 0.0 9e-32 110.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48301.1 - 2.3e-24 86.3 0.0 3e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC48301.1 - 1.9e-06 27.9 0.0 6.4e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 EWC48301.1 - 0.00019 20.7 0.0 0.00029 20.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EWC48301.1 - 0.0075 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EWC48301.1 - 0.23 10.4 0.0 0.34 9.9 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Porin_3 PF01459.22 EWC48302.1 - 2.9e-74 249.9 0.8 3.4e-74 249.7 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic porin Pkinase PF00069.25 EWC48303.1 - 3e-65 220.2 0.0 3.6e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48303.1 - 2.1e-24 86.2 0.0 2.8e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC48303.1 - 1e-05 25.0 0.0 3.5e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EWC48303.1 - 0.00062 19.8 0.2 0.012 15.5 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EWC48303.1 - 0.2 11.0 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like PF12937.7 EWC48304.1 - 3.5e-09 36.4 0.9 9.9e-09 35.0 0.9 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC48304.1 - 7.8e-08 32.0 0.8 1.9e-07 30.8 0.8 1.7 1 0 0 1 1 1 1 F-box domain Cohesin_load PF10345.9 EWC48305.1 - 2.3e-94 317.0 0.0 2.9e-94 316.7 0.0 1.0 1 0 0 1 1 1 1 Cohesin loading factor TPR_14 PF13428.6 EWC48305.1 - 0.52 11.3 10.0 14 6.8 0.0 5.7 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 EWC48305.1 - 0.56 11.0 5.2 22 5.9 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48305.1 - 0.66 10.5 16.9 12 6.5 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48305.1 - 0.75 10.1 11.3 13 6.1 0.0 5.6 6 2 2 8 8 8 0 Tetratricopeptide repeat Cep57_CLD_2 PF14197.6 EWC48306.1 - 0.0041 17.2 1.7 0.022 14.8 1.7 2.4 1 0 0 1 1 1 1 Centrosome localisation domain of PPC89 5_nucleotid PF05761.14 EWC48306.1 - 0.069 12.1 0.9 0.12 11.3 0.9 1.3 1 0 0 1 1 1 0 5' nucleotidase family Filament PF00038.21 EWC48306.1 - 0.95 9.0 12.2 0.013 15.1 3.0 2.2 2 0 0 2 2 2 0 Intermediate filament protein Spc7 PF08317.11 EWC48306.1 - 1.2 8.0 10.7 0.04 12.8 3.9 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 EWC48306.1 - 2.6 7.0 5.7 4 6.4 4.3 1.9 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 EWC48306.1 - 4 7.7 6.6 0.45 10.8 1.1 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.14 EWC48306.1 - 6.7 6.5 8.9 0.41 10.4 3.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) GAS PF13851.6 EWC48306.1 - 8.2 5.7 10.6 0.32 10.3 3.3 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding GTP_EFTU PF00009.27 EWC48307.1 - 6.4e-55 185.7 0.1 1e-54 185.0 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EWC48307.1 - 1.1e-41 141.6 0.0 2.3e-41 140.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EWC48307.1 - 2.3e-13 50.3 3.1 2.3e-13 50.3 3.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EWC48307.1 - 0.00022 21.3 0.2 0.0081 16.2 0.2 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DHBP_synthase PF00926.19 EWC48308.1 - 9e-88 292.8 0.4 1e-87 292.6 0.4 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Imm61 PF15598.6 EWC48308.1 - 0.067 13.1 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 Immunity protein 61 NatB_MDM20 PF09797.9 EWC48308.1 - 0.16 10.9 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit Drf_GBD PF06371.13 EWC48309.1 - 5.8e-05 22.7 0.0 0.00046 19.8 0.0 2.1 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Tub_N PF16322.5 EWC48310.1 - 0.81 10.1 7.0 0.33 11.3 0.7 2.3 1 1 1 2 2 2 0 Tubby N-terminal SDA1 PF05285.12 EWC48310.1 - 0.9 8.9 4.9 1.3 8.4 4.9 1.2 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EWC48310.1 - 3 5.9 12.1 4 5.4 12.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi HSP70 PF00012.20 EWC48311.1 - 4.4e-14 51.6 0.0 1.7e-12 46.4 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein FtsA PF14450.6 EWC48311.1 - 0.0074 16.7 0.1 0.063 13.7 0.0 2.3 2 0 0 2 2 2 1 Cell division protein FtsA Fungal_trans PF04082.18 EWC48312.1 - 2e-15 56.6 0.0 3.5e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48312.1 - 8.5e-07 29.0 11.0 1.7e-06 28.0 11.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HTH_3 PF01381.22 EWC48312.1 - 0.16 12.1 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix SKG6 PF08693.10 EWC48313.1 - 0.03 13.7 0.2 0.064 12.7 0.2 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CD99L2 PF12301.8 EWC48313.1 - 0.05 13.9 0.1 0.069 13.4 0.1 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 HUN PF08729.10 EWC48314.1 - 7.9e-06 25.8 0.3 1.7e-05 24.7 0.3 1.5 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Retinal PF15449.6 EWC48314.1 - 1.5 6.5 29.7 2 6.1 29.7 1.1 1 0 0 1 1 1 0 Retinal protein MDM31_MDM32 PF08118.11 EWC48316.1 - 4.9e-230 764.7 0.0 5.9e-230 764.4 0.0 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Trypan_PARP PF05887.11 EWC48316.1 - 0.0034 17.3 8.8 0.0081 16.1 8.8 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) TraH_2 PF06871.11 EWC48316.1 - 0.0036 17.0 0.4 0.011 15.4 0.1 1.8 2 0 0 2 2 2 1 TraH_2 TonB_N PF16031.5 EWC48316.1 - 0.038 14.5 7.3 0.098 13.2 7.3 1.6 1 0 0 1 1 1 0 TonB polyproline region ATP_synt_H PF05493.13 EWC48317.1 - 0.045 14.2 0.1 0.066 13.7 0.1 1.2 1 0 0 1 1 1 0 ATP synthase subunit H 4HBT PF03061.22 EWC48318.1 - 9.6e-13 48.3 0.2 1.3e-12 47.9 0.2 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EWC48318.1 - 0.0002 21.7 0.0 0.00027 21.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4442 PF14539.6 EWC48318.1 - 0.004 17.3 0.0 0.0054 16.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) Pkinase PF00069.25 EWC48319.1 - 1.1e-47 162.6 0.0 1.8e-47 161.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48319.1 - 1e-26 93.8 0.0 1.5e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC48319.1 - 0.0066 15.8 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EWC48319.1 - 0.014 14.8 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EWC48319.1 - 0.036 14.0 0.0 3.7 7.4 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family QH-AmDH_gamma PF08992.11 EWC48320.1 - 0.12 12.4 0.5 0.43 10.6 0.1 2.0 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, gamma subunit Ank_2 PF12796.7 EWC48321.1 - 2.8e-15 56.6 0.0 0.05 14.2 0.0 6.3 3 1 3 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EWC48321.1 - 2.9e-15 56.1 0.1 0.00045 20.5 0.0 6.4 7 0 0 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC48321.1 - 6e-13 47.7 0.0 0.4 11.4 0.1 7.1 7 0 0 7 7 7 2 Ankyrin repeat Ank_4 PF13637.6 EWC48321.1 - 6.8e-08 32.9 0.2 4.9 7.9 0.0 6.8 6 0 0 6 6 6 1 Ankyrin repeats (many copies) Ank PF00023.30 EWC48321.1 - 9.4e-06 25.9 0.2 1.3 9.6 0.0 5.9 7 0 0 7 7 7 2 Ankyrin repeat NACHT_N PF17100.5 EWC48321.1 - 0.15 11.9 0.9 0.55 10.1 0.0 2.2 2 0 0 2 2 2 0 N-terminal domain of NWD NACHT-NTPase Neisseria_TspB PF05616.13 EWC48321.1 - 0.4 9.1 7.0 0.3 9.5 5.2 1.6 2 0 0 2 2 2 0 Neisseria meningitidis TspB protein WSC PF01822.19 EWC48322.1 - 1.1e-10 41.5 14.9 2.7e-07 30.7 6.6 2.8 2 0 0 2 2 2 2 WSC domain Mito_carr PF00153.27 EWC48323.1 - 2e-67 223.2 6.0 6.9e-24 83.6 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4748 PF15932.5 EWC48323.1 - 0.11 12.2 0.9 0.33 10.7 0.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) P16-Arc PF04699.14 EWC48324.1 - 3e-48 164.1 0.0 3.4e-48 163.9 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Ras PF00071.22 EWC48325.1 - 3.7e-56 189.2 0.0 4.4e-56 188.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EWC48325.1 - 4.6e-34 117.2 0.0 6.9e-34 116.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EWC48325.1 - 1.4e-13 50.7 0.0 3.5e-13 49.4 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EWC48325.1 - 3e-05 23.6 0.0 4.6e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EWC48325.1 - 0.00028 21.0 0.0 0.00069 19.7 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EWC48325.1 - 0.00028 20.3 0.0 0.00041 19.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EWC48325.1 - 0.0006 20.2 0.2 0.00095 19.6 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EWC48325.1 - 0.11 12.4 0.0 3.1 7.7 0.0 2.5 3 0 0 3 3 3 0 RsgA GTPase Fungal_trans PF04082.18 EWC48327.1 - 2.3e-24 85.9 0.0 4.3e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48327.1 - 5e-09 36.1 12.8 8.9e-09 35.3 12.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Caprin-1_dimer PF18293.1 EWC48328.1 - 0.045 14.2 0.2 0.076 13.5 0.2 1.3 1 0 0 1 1 1 0 Caprin-1 dimerization domain DUF2631 PF10939.8 EWC48329.1 - 0.11 12.3 0.7 0.19 11.6 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2631) zf-C2H2 PF00096.26 EWC48330.1 - 0.022 15.2 4.9 0.052 14.0 4.9 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-BED PF02892.15 EWC48330.1 - 0.13 12.3 3.1 0.24 11.4 3.1 1.4 1 0 0 1 1 1 0 BED zinc finger zf-H2C2_2 PF13465.6 EWC48330.1 - 0.45 11.0 2.7 9.7 6.8 0.5 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC48330.1 - 5.6 8.1 8.1 1.9 9.5 5.3 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger Lactonase PF10282.9 EWC48331.1 - 0.022 14.0 0.0 0.52 9.5 0.0 2.6 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller DUF3602 PF12223.8 EWC48332.1 - 1.2e-10 41.9 6.9 0.00027 21.5 1.3 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) PNPase_C PF12111.8 EWC48332.1 - 1 8.9 5.4 14 5.2 0.5 3.2 3 0 0 3 3 3 0 Polyribonucleotide phosphorylase C terminal RFX5_DNA_bdg PF14621.6 EWC48333.1 - 1.4 8.7 8.7 0.024 14.4 0.8 2.2 2 0 0 2 2 2 0 RFX5 DNA-binding domain Chalcone_2 PF16035.5 EWC48334.1 - 7.1e-64 215.3 0.0 1.2e-63 214.6 0.0 1.4 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EWC48334.1 - 0.00027 21.1 0.0 0.025 14.7 0.0 2.3 2 0 0 2 2 2 2 Chalcone isomerase-like LANC_like PF05147.13 EWC48335.1 - 4.9e-22 78.0 0.0 7.9e-22 77.3 0.0 1.2 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein ANAPC4_WD40 PF12894.7 EWC48336.1 - 2e-11 44.0 0.1 0.34 11.2 0.0 7.0 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EWC48336.1 - 6.5e-10 39.5 13.1 1.4 9.9 0.0 9.1 9 0 0 9 9 9 2 WD domain, G-beta repeat NACHT PF05729.12 EWC48336.1 - 3.4e-07 30.3 0.0 6.8e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EWC48336.1 - 9.9e-06 26.0 0.0 3.8e-05 24.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain PQQ_2 PF13360.6 EWC48336.1 - 7e-05 22.5 0.0 0.00094 18.8 0.0 2.5 2 0 0 2 2 2 1 PQQ-like domain PD40 PF07676.12 EWC48336.1 - 0.0003 20.6 0.3 10 6.2 0.0 5.5 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EWC48336.1 - 0.00058 18.9 4.7 0.024 13.6 0.2 4.1 3 2 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA PF00004.29 EWC48336.1 - 0.0024 18.3 0.0 0.07 13.6 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EWC48336.1 - 0.0076 16.5 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EWC48336.1 - 0.021 15.2 0.0 0.19 12.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.20 EWC48336.1 - 0.037 13.9 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Apt1 PF10351.9 EWC48336.1 - 0.049 12.5 0.1 0.079 11.8 0.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain KAP_NTPase PF07693.14 EWC48336.1 - 0.12 11.6 0.3 0.36 10.0 0.2 1.7 1 1 0 1 1 1 0 KAP family P-loop domain AAA_30 PF13604.6 EWC48336.1 - 0.15 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Glutaredoxin PF00462.24 EWC48337.1 - 2.4e-18 66.1 0.1 3.4e-18 65.6 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 EWC48337.1 - 6.2e-06 26.5 0.0 8.8e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 EWC48337.1 - 0.0026 18.1 0.1 0.0034 17.7 0.1 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 EWC48337.1 - 0.0064 16.9 0.0 0.0072 16.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain DSBA PF01323.20 EWC48337.1 - 0.008 16.0 0.0 0.39 10.5 0.0 2.1 1 1 1 2 2 2 1 DSBA-like thioredoxin domain GST_N_2 PF13409.6 EWC48337.1 - 0.012 15.9 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain HAMP_N3 PF18575.1 EWC48339.1 - 0.12 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 HAMP N-terminal domain 3 Ctr PF04145.15 EWC48340.1 - 4.9e-36 124.6 0.3 6.2e-36 124.2 0.3 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Dynactin_p62 PF05502.13 EWC48341.1 - 7.7e-120 400.9 18.1 2e-66 224.8 0.1 2.1 1 1 1 2 2 2 2 Dynactin p62 family Glyco_transf_22 PF03901.17 EWC48341.1 - 0.38 9.9 1.5 3 7.0 0.2 2.1 1 1 1 2 2 2 0 Alg9-like mannosyltransferase family BAG PF02179.16 EWC48343.1 - 8.4e-18 64.6 0.2 1.5e-17 63.8 0.2 1.4 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 EWC48343.1 - 1e-05 25.2 0.0 2.7e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 EWC48343.1 - 0.078 12.8 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Mst1_SARAH PF11629.8 EWC48343.1 - 0.09 12.9 0.1 0.43 10.7 0.0 2.0 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Ubiquitin_4 PF18036.1 EWC48343.1 - 0.22 11.6 0.0 1.1 9.3 0.0 2.1 1 1 0 1 1 1 0 Ubiquitin-like domain HMG_box PF00505.19 EWC48345.1 - 7.4e-18 64.7 4.2 2.3e-09 37.5 0.2 3.2 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EWC48345.1 - 1.6e-15 57.4 6.1 2.3e-08 34.5 0.7 3.0 2 1 0 2 2 2 2 HMG-box domain HC2 PF07382.11 EWC48345.1 - 2.2e-08 34.4 55.8 2.2e-08 34.4 55.8 1.9 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 Med16 PF11635.8 EWC48346.1 - 1.9e-113 380.0 0.1 2.2e-113 379.8 0.1 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 GH97_C PF14509.6 EWC48346.1 - 0.17 12.1 0.0 0.46 10.7 0.0 1.7 1 0 0 1 1 1 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation ESCRT-II PF05871.12 EWC48347.1 - 6.4e-50 169.0 0.1 7.8e-50 168.8 0.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit PTCB-BRCT PF12738.7 EWC48348.1 - 7.1e-28 96.3 0.0 1.9e-16 59.7 0.0 5.0 5 0 0 5 5 5 3 twin BRCT domain RTT107_BRCT_5 PF16770.5 EWC48348.1 - 1.6e-27 95.3 0.0 5.9e-25 87.1 0.0 3.5 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EWC48348.1 - 6.5e-22 77.7 0.0 2.2e-05 24.8 0.0 6.2 6 1 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EWC48348.1 - 3.4e-21 75.4 0.0 0.011 16.1 0.0 6.1 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EWC48348.1 - 2.8e-09 37.2 0.3 0.0099 16.1 0.0 4.7 4 0 0 4 4 4 3 DNA ligase 3 BRCT domain RBR PF17208.3 EWC48348.1 - 0.0067 17.1 0.0 0.0067 17.1 0.0 2.4 2 0 0 2 2 2 1 RNA binding Region ATP-synt_10 PF05176.14 EWC48349.1 - 2.6e-67 226.8 0.0 5.7e-66 222.4 0.0 2.0 1 1 0 1 1 1 1 ATP10 protein RRM_1 PF00076.22 EWC48350.1 - 9.4e-19 67.0 0.1 3.8e-09 36.2 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EWC48350.1 - 0.0073 16.4 0.0 0.019 15.1 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif Striatin PF08232.12 EWC48350.1 - 0.059 14.0 2.2 0.077 13.6 0.5 1.9 2 0 0 2 2 2 0 Striatin family RRM_3 PF08777.11 EWC48350.1 - 0.089 12.8 0.9 0.31 11.1 0.3 2.2 3 0 0 3 3 3 0 RNA binding motif U1snRNP70_N PF12220.8 EWC48350.1 - 0.095 13.3 1.3 0.23 12.1 0.1 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Peptidase_S49_N PF08496.10 EWC48350.1 - 0.15 12.1 5.6 0.65 10.1 0.3 2.8 3 0 0 3 3 3 0 Peptidase family S49 N-terminal DUF3761 PF12587.8 EWC48350.1 - 0.2 12.1 0.9 0.54 10.7 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) Ammonium_transp PF00909.21 EWC48351.1 - 4.4e-116 387.8 21.6 5.1e-116 387.7 21.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Phage_holin_2_1 PF04971.12 EWC48351.1 - 3.5 7.7 10.0 0.18 11.8 0.6 3.4 4 0 0 4 4 4 0 Bacteriophage P21 holin S Pkinase PF00069.25 EWC48353.1 - 5.9e-71 238.9 0.0 1.2e-70 237.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48353.1 - 5.5e-41 140.6 0.0 9.3e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EWC48353.1 - 2.3e-06 27.2 0.0 4.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EWC48353.1 - 7.7e-05 21.6 0.0 0.00017 20.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EWC48353.1 - 0.00035 20.6 0.0 0.001 19.1 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EWC48353.1 - 0.0025 16.9 0.0 0.0045 16.1 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 DUF507 PF04368.13 EWC48353.1 - 0.01 15.8 3.6 0.18 11.7 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF507) Kdo PF06293.14 EWC48353.1 - 0.037 13.4 0.2 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RSRP PF17069.5 EWC48353.1 - 0.048 13.2 4.4 0.12 12.0 4.4 1.5 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 CBFD_NFYB_HMF PF00808.23 EWC48354.1 - 2.2e-12 47.0 0.0 6e-12 45.7 0.0 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EWC48354.1 - 0.00013 22.4 4.0 0.00017 22.0 0.0 2.7 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EWC48354.1 - 0.0031 17.6 0.0 0.0058 16.7 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIIA PF03153.13 EWC48354.1 - 3.1 7.7 23.3 4.1 7.3 23.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_L29 PF00831.23 EWC48355.1 - 2.2e-18 65.9 0.5 2.2e-18 65.9 0.5 2.4 2 1 1 3 3 3 1 Ribosomal L29 protein Snapin_Pallidin PF14712.6 EWC48355.1 - 0.015 15.7 1.2 0.015 15.7 1.2 1.9 1 1 1 2 2 2 0 Snapin/Pallidin LktC PF06261.11 EWC48355.1 - 0.089 12.7 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Actinobacillus actinomycetemcomitans leukotoxin activator LktC V-SNARE_C PF12352.8 EWC48356.1 - 1e-11 44.9 0.2 1e-11 44.9 0.2 2.5 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EWC48356.1 - 0.047 13.6 3.9 2.9 7.9 0.0 3.2 3 1 0 3 3 3 0 Sec20 Het-C PF07217.11 EWC48356.1 - 0.095 11.2 2.9 0.29 9.6 0.1 2.0 1 1 1 2 2 2 0 Heterokaryon incompatibility protein Het-C Allexi_40kDa PF05549.11 EWC48356.1 - 1 8.8 6.6 0.54 9.7 2.2 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein FliD_N PF02465.18 EWC48356.1 - 1.8 9.3 7.3 2 9.2 1.3 2.3 1 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus SLD3 PF08639.10 EWC48357.1 - 2.4e-100 336.8 15.5 2.4e-100 336.8 15.5 2.9 2 1 0 2 2 2 1 DNA replication regulator SLD3 ZapB PF06005.12 EWC48359.1 - 0.02 15.3 5.1 0.02 15.3 5.1 7.3 3 2 0 5 5 5 0 Cell division protein ZapB Pox_A_type_inc PF04508.12 EWC48359.1 - 0.092 12.6 7.3 7.3 6.6 0.2 5.3 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat TraF_2 PF13729.6 EWC48359.1 - 0.98 8.7 3.5 1.8 7.9 0.1 2.6 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein Abhydrolase_6 PF12697.7 EWC48360.1 - 5.4e-11 43.5 1.0 9.3e-11 42.7 1.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC48360.1 - 2.1e-07 30.5 0.0 4.3e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EWC48360.1 - 8.3e-05 22.3 0.0 0.00028 20.6 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase PF07224.11 EWC48360.1 - 0.042 12.9 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase DUF3808 PF10300.9 EWC48361.1 - 1.7e-128 429.3 1.8 2.1e-128 429.1 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EWC48361.1 - 4.4 7.7 5.6 13 6.1 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat DSS1_SEM1 PF05160.13 EWC48362.1 - 2e-23 82.2 15.7 2.6e-23 81.8 15.7 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family Cwf_Cwc_15 PF04889.12 EWC48362.1 - 0.11 12.2 8.9 0.12 12.1 8.9 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PhoU PF01895.19 EWC48362.1 - 0.18 12.3 0.9 19 5.8 0.2 2.1 2 0 0 2 2 2 0 PhoU domain ketoacyl-synt PF00109.26 EWC48362.1 - 0.24 10.9 1.3 0.28 10.7 1.3 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain PGK PF00162.19 EWC48363.1 - 4.7e-148 493.2 0.6 5.4e-148 493.0 0.6 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 EWC48363.1 - 0.003 17.5 0.1 0.32 11.1 0.0 3.2 3 1 1 4 4 4 1 PA domain AlaDh_PNT_C PF01262.21 EWC48363.1 - 0.15 11.4 1.2 0.42 9.9 1.2 1.7 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EWC48363.1 - 0.6 10.7 4.0 19 5.9 0.3 3.9 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase AhpC-TSA_2 PF13911.6 EWC48364.1 - 2.5e-08 34.0 0.0 3.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EWC48364.1 - 0.00039 20.3 0.0 0.00062 19.7 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EWC48364.1 - 0.036 13.8 0.0 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 Redoxin DNA_pol_B_palm PF14792.6 EWC48365.1 - 9.9e-31 106.3 0.0 2.1e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EWC48365.1 - 2.4e-24 85.2 0.2 1.5e-23 82.8 0.1 2.2 2 0 0 2 2 2 1 DNA polymerase beta thumb HHH_8 PF14716.6 EWC48365.1 - 9.8e-13 48.3 0.0 2.1e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 EWC48365.1 - 5.8e-12 45.3 0.0 6.2e-11 41.9 0.0 2.4 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda BRCT_2 PF16589.5 EWC48365.1 - 8.3e-06 26.1 0.0 1.6e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EWC48365.1 - 2e-05 24.9 0.0 4.8e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain NTP_transf_2 PF01909.23 EWC48365.1 - 0.013 15.8 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase domain Stm1_N PF09598.10 EWC48365.1 - 0.04 14.7 0.6 0.04 14.7 0.6 3.7 3 2 0 3 3 3 0 Stm1 HHH_5 PF14520.6 EWC48365.1 - 0.075 13.6 0.1 3 8.5 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix domain Dicty_REP PF05086.12 EWC48365.1 - 0.34 8.8 1.1 0.47 8.4 1.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SNF2_N PF00176.23 EWC48367.1 - 3.3e-61 206.9 2.3 5.6e-61 206.2 2.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 EWC48367.1 - 1e-21 76.6 0.2 3.9e-13 49.1 0.0 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EWC48367.1 - 2.7e-20 72.8 0.1 8.5e-20 71.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 EWC48367.1 - 2.6e-11 43.8 0.8 2.6e-11 43.8 0.8 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Cdh1_DBD_1 PF18196.1 EWC48367.1 - 7e-10 39.3 3.6 5.6e-08 33.1 0.4 4.5 4 1 1 5 5 5 2 Chromodomain helicase DNA-binding domain 1 HDA2-3 PF11496.8 EWC48367.1 - 1e-07 31.4 0.3 4.3e-07 29.4 0.3 2.1 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EWC48367.1 - 2.3e-07 31.0 2.3 1.5e-06 28.4 0.0 3.2 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit CDH1_2_SANT_HL1 PF18375.1 EWC48367.1 - 0.0059 17.3 3.5 0.0085 16.7 0.1 3.2 3 0 0 3 3 3 1 CDH1/2 SANT-Helical linker 1 SLIDE PF09111.10 EWC48367.1 - 0.025 14.6 0.0 0.2 11.7 0.0 2.6 1 0 0 1 1 1 0 SLIDE Glyco_hydro_61 PF03443.14 EWC48368.1 - 6.5e-47 160.1 1.6 7.9e-47 159.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EWC48368.1 - 1.4e-12 47.3 11.5 1.4e-12 47.3 11.5 2.0 2 0 0 2 2 2 1 Fungal cellulose binding domain ATP_bind_1 PF03029.17 EWC48369.1 - 6.4e-83 278.2 0.0 7.3e-83 278.0 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EWC48369.1 - 9.9e-05 22.2 0.0 0.00022 21.1 0.0 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 EWC48369.1 - 0.00014 22.4 0.1 0.0008 20.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EWC48369.1 - 0.00027 21.3 0.6 0.012 16.0 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EWC48369.1 - 0.0029 17.6 0.0 0.0065 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EWC48369.1 - 0.0029 17.5 0.2 0.01 15.7 0.2 2.0 1 1 0 1 1 1 1 NACHT domain AAA PF00004.29 EWC48369.1 - 0.0039 17.6 0.0 0.0075 16.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EWC48369.1 - 0.006 16.5 0.0 0.044 13.7 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EWC48369.1 - 0.0071 16.7 0.0 0.021 15.2 0.0 1.8 2 0 0 2 2 2 1 RNA helicase GTP_EFTU PF00009.27 EWC48369.1 - 0.011 15.3 0.1 2.7 7.5 0.1 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain G-alpha PF00503.20 EWC48369.1 - 0.026 13.7 0.3 3.6 6.6 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit T2SSE PF00437.20 EWC48369.1 - 0.028 13.5 0.0 0.044 12.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 EWC48369.1 - 0.042 13.6 0.0 0.1 12.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EWC48369.1 - 0.044 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 EWC48369.1 - 0.044 13.4 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 EWC48369.1 - 0.071 12.9 0.1 0.69 9.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EWC48369.1 - 0.076 12.6 0.1 12 5.4 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 EWC48369.1 - 0.084 12.9 0.0 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 EWC48369.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 EWC48369.1 - 0.12 12.6 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EWC48369.1 - 0.13 12.6 0.0 0.43 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EWC48369.1 - 0.14 11.9 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EWC48369.1 - 0.18 11.2 0.0 0.64 9.4 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EWC48369.1 - 0.2 11.0 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 EWC48369.1 - 0.21 11.5 0.1 25 4.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase SIR2 PF02146.17 EWC48370.1 - 8.5e-27 94.2 0.0 2.9e-26 92.5 0.0 1.9 1 1 0 1 1 1 1 Sir2 family Totivirus_coat PF05518.11 EWC48370.1 - 1.7 6.6 7.0 14 3.6 4.7 2.1 2 0 0 2 2 2 0 Totivirus coat protein NMO PF03060.15 EWC48371.1 - 2e-54 185.2 0.7 7.2e-54 183.4 0.7 1.7 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EWC48371.1 - 2.3e-13 49.9 0.0 1.2e-11 44.2 0.0 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain DUF1902 PF08972.11 EWC48371.1 - 0.0026 17.7 0.0 0.008 16.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1902) TMP-TENI PF02581.17 EWC48371.1 - 0.0035 16.7 0.2 0.12 11.7 0.1 2.3 2 0 0 2 2 2 1 Thiamine monophosphate synthase FMN_dh PF01070.18 EWC48371.1 - 0.004 16.2 0.1 0.0075 15.3 0.1 1.5 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.14 EWC48371.1 - 0.0077 15.4 0.1 0.012 14.8 0.1 1.3 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 EWC48371.1 - 0.038 13.4 0.1 0.085 12.3 0.1 1.6 2 0 0 2 2 2 0 Histidine biosynthesis protein Ank_2 PF12796.7 EWC48372.1 - 8e-10 39.2 0.1 2.3e-09 37.7 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC48372.1 - 1.5e-09 38.2 0.3 8.9e-07 29.4 0.3 2.2 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EWC48372.1 - 6.4e-08 32.7 1.9 0.0022 18.4 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EWC48372.1 - 8.2e-08 31.9 0.7 0.34 11.6 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EWC48372.1 - 6.6e-05 23.1 1.1 0.005 17.1 0.2 2.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) ABC_tran PF00005.27 EWC48374.1 - 1.2e-35 123.0 0.0 2.7e-17 63.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 EWC48374.1 - 2.5e-13 49.6 4.5 2.5e-13 49.6 4.5 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 EWC48374.1 - 1.2e-11 44.5 1.6 0.00038 20.0 0.0 3.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EWC48374.1 - 1.8e-09 37.9 6.1 0.42 10.4 0.0 4.4 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EWC48374.1 - 3.6e-06 26.9 0.1 0.17 11.6 0.0 3.2 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EWC48374.1 - 4.4e-06 27.0 0.2 0.0086 16.4 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EWC48374.1 - 6.1e-06 26.7 0.1 0.081 13.3 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EWC48374.1 - 7.2e-05 22.8 0.0 0.55 10.1 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase Fer4 PF00037.27 EWC48374.1 - 8.3e-05 22.2 2.5 8.3e-05 22.2 2.5 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_16 PF13191.6 EWC48374.1 - 8.4e-05 23.0 0.0 0.48 10.8 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 EWC48374.1 - 0.00013 21.7 0.6 0.21 11.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EWC48374.1 - 0.00023 21.7 0.7 1.2 9.7 0.0 3.0 2 1 1 3 3 3 2 AAA domain Rad17 PF03215.15 EWC48374.1 - 0.00054 19.9 0.0 0.026 14.5 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain NB-ARC PF00931.22 EWC48374.1 - 0.0012 18.1 0.0 0.063 12.5 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_29 PF13555.6 EWC48374.1 - 0.0014 18.3 0.2 1.3 8.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 EWC48374.1 - 0.0017 18.8 0.1 1.6 9.1 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_13 PF13166.6 EWC48374.1 - 0.0018 17.0 4.1 0.0052 15.5 0.0 3.0 3 1 1 4 4 4 1 AAA domain Fer4_21 PF14697.6 EWC48374.1 - 0.0022 18.1 11.1 0.0044 17.1 11.1 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain SRP54 PF00448.22 EWC48374.1 - 0.0024 17.6 1.8 0.25 10.9 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EWC48374.1 - 0.0028 17.8 0.0 2.3 8.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EWC48374.1 - 0.0055 16.7 0.0 0.46 10.5 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EWC48374.1 - 0.0071 16.3 1.9 0.87 9.5 0.1 2.7 3 0 0 3 3 2 1 NACHT domain AAA_28 PF13521.6 EWC48374.1 - 0.0078 16.5 0.2 4.3 7.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 EWC48374.1 - 0.016 15.3 1.8 0.016 15.3 1.8 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 EWC48374.1 - 0.031 14.4 2.9 0.031 14.4 2.9 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain MMR_HSR1 PF01926.23 EWC48374.1 - 0.033 14.3 0.1 6.2 6.9 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.17 EWC48374.1 - 0.047 13.4 0.6 10 5.8 0.0 3.0 3 1 0 3 3 3 0 Thymidylate kinase AAA_7 PF12775.7 EWC48374.1 - 0.061 12.8 0.0 2.1 7.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EWC48374.1 - 0.074 12.8 4.0 3.2 7.4 0.0 3.2 2 2 0 2 2 2 0 AAA domain Fer4_9 PF13187.6 EWC48374.1 - 0.094 12.9 11.7 0.19 11.9 11.7 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 EWC48374.1 - 0.11 13.5 0.3 0.11 13.5 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain DUF359 PF04019.12 EWC48374.1 - 0.11 12.1 0.1 0.29 10.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF359) AAA_5 PF07728.14 EWC48374.1 - 0.11 12.4 0.2 8.5 6.4 0.0 3.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EWC48374.1 - 0.16 12.0 1.4 34 4.5 0.0 3.5 2 1 1 3 3 3 0 AAA domain PduV-EutP PF10662.9 EWC48374.1 - 0.29 10.9 2.0 0.34 10.6 0.1 2.1 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation Fer4_8 PF13183.6 EWC48374.1 - 0.4 11.2 6.6 0.38 11.2 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain AAA_23 PF13476.6 EWC48374.1 - 0.5 10.8 7.8 0.8 10.2 0.1 2.9 2 1 0 2 2 2 0 AAA domain Fer4_7 PF12838.7 EWC48374.1 - 1 10.0 12.3 0.068 13.8 1.5 2.3 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 EWC48374.1 - 1.1 9.6 9.9 0.25 11.5 1.2 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain FF PF01846.19 EWC48375.1 - 2.8e-52 174.7 19.3 3.2e-13 49.6 0.3 6.7 6 0 0 6 6 6 6 FF domain WW PF00397.26 EWC48375.1 - 5.2e-14 52.0 10.6 1.2e-07 31.7 0.3 2.9 2 0 0 2 2 2 2 WW domain DUF5525 PF17663.1 EWC48375.1 - 0.057 11.5 8.2 0.082 11.0 8.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5525) aGPT-Pplase2 PF18724.1 EWC48375.1 - 0.23 11.2 5.2 0.39 10.4 1.3 2.4 1 1 1 2 2 2 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 2 DUF5338 PF17273.2 EWC48375.1 - 2 8.6 6.0 0.24 11.5 0.3 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5338) Trs65 PF12735.7 EWC48376.1 - 1.1e-63 215.6 0.3 3.8e-63 213.8 0.3 1.9 1 1 0 1 1 1 1 TRAPP trafficking subunit Trs65 Mpv17_PMP22 PF04117.12 EWC48376.1 - 2.3e-20 72.6 0.2 5.6e-20 71.3 0.2 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family S-AdoMet_synt_C PF02773.16 EWC48377.1 - 2.9e-65 218.4 0.1 5.9e-65 217.4 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 EWC48377.1 - 3.4e-45 152.8 0.2 8.3e-45 151.5 0.2 1.7 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 EWC48377.1 - 1e-43 148.4 0.0 2e-43 147.5 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 EWC48377.1 - 0.0064 15.3 0.2 0.087 11.6 0.1 2.1 1 1 0 2 2 2 1 S-adenosylmethionine synthetase (AdoMet synthetase) Nup160 PF11715.8 EWC48379.1 - 8.4e-77 259.0 0.1 1.1e-76 258.6 0.1 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ATP_transf PF09830.9 EWC48380.1 - 2.1e-17 63.0 0.2 3.3e-17 62.4 0.2 1.3 1 0 0 1 1 1 1 ATP adenylyltransferase CorA PF01544.18 EWC48381.1 - 7.6e-07 28.7 5.3 2.2e-06 27.2 5.4 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Phage_holin_3_6 PF07332.11 EWC48381.1 - 0.097 12.7 2.2 0.15 12.1 2.2 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III CPL PF08144.11 EWC48382.1 - 9.3e-33 113.6 11.7 4.8e-32 111.3 0.1 5.3 5 1 1 6 6 6 1 CPL (NUC119) domain Cucumopine_C PF18631.1 EWC48382.1 - 0.056 13.4 0.1 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 Cucumopine synthase C-terminal helical bundle domain DUF4476 PF14771.6 EWC48382.1 - 0.1 12.9 0.0 0.71 10.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) Macoilin PF09726.9 EWC48382.1 - 1.2 7.6 11.2 2.1 6.8 11.2 1.3 1 0 0 1 1 1 0 Macoilin family PBP1_TM PF14812.6 EWC48382.1 - 1.3 9.5 8.9 7.7 7.0 8.9 2.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CCDC106 PF15794.5 EWC48382.1 - 2.4 7.8 12.0 6.1 6.5 11.9 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 106 TFIIF_alpha PF05793.12 EWC48382.1 - 3.3 6.2 23.4 5.3 5.5 23.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Rad51 PF08423.11 EWC48383.1 - 2.5e-128 426.7 0.0 3.2e-128 426.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EWC48383.1 - 2.2e-11 43.8 0.1 3e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EWC48383.1 - 3e-10 40.0 0.0 4.8e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EWC48383.1 - 6e-09 36.4 0.7 1.9e-08 34.8 0.7 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 EWC48383.1 - 2.3e-05 23.9 0.1 4.2e-05 23.0 0.1 1.5 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EWC48383.1 - 0.012 15.0 0.1 0.14 11.4 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EWC48383.1 - 0.037 14.3 0.2 0.12 12.7 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EWC48383.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain HHH PF00633.23 EWC48383.1 - 0.15 12.0 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif ssDNA_TraI_N PF18272.1 EWC48383.1 - 0.16 12.0 2.5 0.19 11.7 0.7 2.0 2 0 0 2 2 2 0 single-stranded DNA binding TraI N-terminal subdomain PAXNEB PF05625.11 EWC48383.1 - 0.21 10.7 0.2 0.41 9.7 0.1 1.4 2 0 0 2 2 2 0 PAXNEB protein Dna2 PF08696.11 EWC48384.1 - 4.1e-67 225.9 0.0 7.8e-67 225.0 0.0 1.5 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 EWC48384.1 - 1.7e-52 178.0 0.0 2.8e-52 177.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EWC48384.1 - 2e-33 116.3 1.1 6e-17 62.3 0.1 2.9 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 EWC48384.1 - 6.3e-14 52.1 0.0 1.3e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EWC48384.1 - 1.8e-11 44.6 0.1 5.8e-11 42.9 0.1 2.0 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EWC48384.1 - 3.8e-06 26.8 1.1 0.48 10.1 0.1 3.9 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 EWC48384.1 - 6.6e-06 26.3 0.0 2.9e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function DUF83 Helicase_RecD PF05127.14 EWC48384.1 - 1.9e-05 24.6 0.0 4.3e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 EWC48384.1 - 0.00017 21.2 0.0 0.00039 20.0 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain SRP54 PF00448.22 EWC48384.1 - 0.0014 18.3 0.1 0.0027 17.4 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EWC48384.1 - 0.0017 18.8 0.2 0.0068 16.8 0.0 2.2 2 0 0 2 2 1 1 AAA ATPase domain PIF1 PF05970.14 EWC48384.1 - 0.0066 15.7 0.1 0.11 11.7 0.1 2.2 2 0 0 2 2 2 1 PIF1-like helicase ResIII PF04851.15 EWC48384.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CbiA PF01656.23 EWC48384.1 - 0.017 15.2 0.2 0.049 13.7 0.2 1.7 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 EWC48384.1 - 0.041 13.5 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EWC48384.1 - 0.046 13.2 0.1 0.12 11.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF87 PF01935.17 EWC48384.1 - 0.065 13.3 0.1 0.21 11.6 0.1 1.8 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_25 PF13481.6 EWC48384.1 - 0.08 12.5 0.0 0.25 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EWC48384.1 - 0.1 13.2 0.0 0.62 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EWC48384.1 - 0.11 11.5 0.3 0.24 10.3 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EWC48384.1 - 0.16 11.9 0.2 0.47 10.4 0.2 1.7 1 0 0 1 1 1 0 NTPase Mito_carr PF00153.27 EWC48385.1 - 8.6e-66 217.9 1.6 3.2e-24 84.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 EWC48385.1 - 0.00073 19.9 3.7 0.013 15.8 1.9 3.0 1 1 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Ank_5 PF13857.6 EWC48386.1 - 2.7e-14 53.0 0.4 1.4e-13 50.7 0.2 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EWC48386.1 - 3.6e-12 46.5 1.2 9.4e-07 29.3 0.1 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EWC48386.1 - 4.9e-11 43.1 0.0 8.7e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EWC48386.1 - 9.3e-09 34.8 0.1 3.5e-06 26.9 0.2 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EWC48386.1 - 6.2e-08 32.7 0.8 1e-05 25.8 0.4 3.3 3 0 0 3 3 3 1 Ankyrin repeat VHL_C PF17211.3 EWC48386.1 - 0.054 13.5 0.0 1.8 8.7 0.0 2.6 2 0 0 2 2 2 0 VHL box domain Myb_DNA-binding PF00249.31 EWC48386.1 - 0.076 13.2 1.7 7.4 6.8 0.1 3.2 3 0 0 3 3 3 0 Myb-like DNA-binding domain Abhydrolase_2 PF02230.16 EWC48387.1 - 3.4e-24 85.8 0.0 8.1e-19 68.3 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EWC48387.1 - 0.035 13.6 0.0 0.1 12.1 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family DFP PF04127.15 EWC48388.1 - 0.091 12.6 0.1 0.23 11.3 0.1 1.7 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein IZUMO PF15005.6 EWC48388.1 - 0.79 10.2 3.3 3.5 8.1 0.0 2.9 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated UQ_con PF00179.26 EWC48389.1 - 1.1e-10 41.3 0.0 2.7e-08 33.5 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Sec7_N PF12783.7 EWC48390.1 - 2.1e-43 147.9 0.3 1.1e-42 145.6 0.0 2.5 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EWC48390.1 - 5.3e-41 140.2 4.1 5.3e-41 140.2 4.1 2.5 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Mon2_C PF16206.5 EWC48390.1 - 4.4e-31 107.8 2.0 1e-24 86.8 1.3 2.7 3 1 0 3 3 3 2 C-terminal region of Mon2 protein DUF1981 PF09324.10 EWC48390.1 - 9.9e-07 28.5 0.1 0.0069 16.2 0.0 4.3 5 0 0 5 5 5 2 Domain of unknown function (DUF1981) UPF0020 PF01170.18 EWC48391.1 - 9.7e-06 25.4 0.1 0.00035 20.3 0.1 2.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EWC48391.1 - 0.17 11.5 0.0 0.79 9.4 0.0 2.0 2 0 0 2 2 2 0 DNA methylase Ribosomal_L2_C PF03947.18 EWC48392.1 - 2e-51 173.4 0.9 5.2e-51 172.1 0.9 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EWC48392.1 - 9.7e-26 89.5 0.4 2.5e-25 88.3 0.4 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Fungal_trans PF04082.18 EWC48393.1 - 6.8e-16 58.1 0.0 1.9e-15 56.7 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48393.1 - 1.6e-09 37.7 9.0 3e-09 36.8 9.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex14_N PF04695.13 EWC48393.1 - 0.73 10.5 8.5 1.5 9.5 7.2 2.1 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HIT PF01230.23 EWC48394.1 - 2.9e-14 53.6 0.0 2.3e-07 31.5 0.0 2.3 2 0 0 2 2 2 2 HIT domain DcpS_C PF11969.8 EWC48394.1 - 0.0023 18.4 0.0 0.7 10.4 0.0 2.4 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EWC48394.1 - 0.0097 15.8 1.5 0.4 10.5 0.4 2.9 2 1 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 Tim54 PF11711.8 EWC48394.1 - 0.019 13.8 0.2 0.03 13.1 0.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2946 PF11162.8 EWC48394.1 - 0.042 14.5 0.4 0.14 12.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) Cyclin_N PF00134.23 EWC48395.1 - 2.6e-46 156.5 0.0 6.8e-43 145.4 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EWC48395.1 - 4.4e-35 120.3 0.1 8.3e-35 119.5 0.1 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain FUSC_2 PF13515.6 EWC48396.1 - 2.5e-15 56.7 22.0 8.1e-15 55.1 5.7 2.6 2 0 0 2 2 2 2 Fusaric acid resistance protein-like ArAE_2_N PF10337.9 EWC48396.1 - 2.9e-09 36.5 11.8 3.4e-06 26.4 3.2 3.4 1 1 1 2 2 2 2 Putative ER transporter, 6TM, N-terminal ALMT PF11744.8 EWC48396.1 - 5.2e-07 28.9 0.7 5.2e-07 28.9 0.7 1.6 2 0 0 2 2 2 1 Aluminium activated malate transporter ArAE_2 PF10334.9 EWC48396.1 - 3.6e-05 23.7 0.0 8.8e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC PF04632.12 EWC48396.1 - 0.00056 18.6 19.8 0.0011 17.6 5.4 2.6 3 0 0 3 3 3 2 Fusaric acid resistance protein family ArAE_1 PF06081.11 EWC48396.1 - 0.1 12.7 4.9 0.032 14.4 0.9 2.1 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 DUF1097 PF06496.11 EWC48396.1 - 0.24 11.5 27.0 0.071 13.2 7.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1097) WD40 PF00400.32 EWC48397.1 - 6.3e-16 58.5 12.9 1.1e-05 26.1 0.0 5.9 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48397.1 - 1.1e-14 54.5 0.0 0.0025 18.0 0.0 4.6 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 EWC48397.1 - 7.5e-05 22.2 0.0 0.00035 20.0 0.0 2.0 1 1 1 2 2 2 1 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 EWC48397.1 - 0.00031 20.2 0.0 0.1 11.9 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 EWC48397.1 - 0.005 15.4 0.1 1.5 7.2 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain Ribonuc_P_40 PF08584.11 EWC48398.1 - 1.2e-78 264.3 0.0 1.5e-78 264.0 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit La PF05383.17 EWC48399.1 - 3.8e-16 58.9 0.3 7e-16 58.0 0.3 1.5 1 0 0 1 1 1 1 La domain Got1 PF04178.12 EWC48400.1 - 2e-35 121.6 14.5 2.7e-35 121.2 14.5 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family AgrB PF04647.15 EWC48400.1 - 0.7 9.2 7.7 0.9 8.8 7.7 1.1 1 0 0 1 1 1 0 Accessory gene regulator B HLH PF00010.26 EWC48401.1 - 8.9e-12 44.8 0.2 4.6e-11 42.5 0.2 2.1 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain RNA_lig_T4_1 PF09511.10 EWC48402.1 - 8.1e-84 280.9 0.0 1.3e-83 280.2 0.0 1.3 1 0 0 1 1 1 1 RNA ligase tRNA_lig_CPD PF08302.11 EWC48402.1 - 4.3e-43 147.6 0.0 6.5e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.11 EWC48402.1 - 5.1e-26 91.8 0.1 2.4e-24 86.3 0.0 2.4 1 1 1 2 2 2 1 tRNA ligase kinase domain RNA_ligase PF09414.10 EWC48402.1 - 0.00071 19.9 0.1 0.0015 18.9 0.1 1.5 1 0 0 1 1 1 1 RNA ligase CHCH PF06747.13 EWC48403.1 - 2.5e-05 24.3 0.3 3.7e-05 23.7 0.3 1.3 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 EWC48403.1 - 0.0026 18.0 2.1 0.0071 16.6 2.1 1.7 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.13 EWC48403.1 - 0.0046 17.3 1.5 1.1 9.7 0.1 2.3 1 1 1 2 2 2 2 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EWC48403.1 - 0.038 14.0 1.4 0.063 13.3 1.4 1.3 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like UPF0203 PF05254.12 EWC48403.1 - 0.1 12.9 1.6 2.8 8.3 0.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) SIR2 PF02146.17 EWC48404.1 - 2.4e-60 203.5 0.0 4e-60 202.7 0.0 1.4 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EWC48404.1 - 0.00046 20.0 0.0 0.00098 18.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EWC48404.1 - 0.016 15.0 0.0 3.2 7.5 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain GAT PF03127.14 EWC48405.1 - 0.02 15.2 0.6 0.044 14.1 0.6 1.5 1 0 0 1 1 1 0 GAT domain ATG16 PF08614.11 EWC48405.1 - 0.027 14.7 7.3 0.048 13.9 7.3 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) RNA_pol_A_CTD PF03118.15 EWC48405.1 - 0.073 12.8 0.9 0.49 10.2 0.2 2.4 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain FliT PF05400.13 EWC48405.1 - 1.3 9.9 9.2 0.44 11.4 5.5 2.0 2 0 0 2 2 2 0 Flagellar protein FliT RMI1_N PF08585.12 EWC48406.1 - 0.1 12.3 0.9 0.23 11.2 0.9 1.5 1 0 0 1 1 1 0 RecQ mediated genome instability protein FlxA PF14282.6 EWC48406.1 - 2.2 8.3 7.8 0.069 13.2 1.3 1.9 2 0 0 2 2 2 0 FlxA-like protein Cofilin_ADF PF00241.20 EWC48407.1 - 7.2e-19 67.8 0.0 8.2e-19 67.6 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF5038 PF16441.5 EWC48407.1 - 0.066 13.2 0.0 0.099 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5038) Hydrolase PF00702.26 EWC48407.1 - 0.086 13.1 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NPR3 PF03666.13 EWC48408.1 - 1.2e-142 476.1 0.0 1.2e-142 476.1 0.0 2.0 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 BUD22 PF09073.10 EWC48408.1 - 0.012 15.0 12.4 0.024 14.0 12.4 1.4 1 0 0 1 1 1 0 BUD22 Tic110 PF16940.5 EWC48408.1 - 0.029 12.9 0.7 0.041 12.4 0.7 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter SF3A2 PF16835.5 EWC48409.1 - 1.1e-39 134.6 0.1 1.7e-39 134.1 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EWC48409.1 - 4.1e-06 27.0 1.1 7.6e-06 26.1 1.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 EWC48409.1 - 2.5e-05 24.2 1.2 3.9e-05 23.6 1.2 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 EWC48409.1 - 0.24 11.0 3.1 0.42 10.2 3.1 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Abhydrolase_6 PF12697.7 EWC48410.1 - 5.5e-07 30.4 0.6 7.6e-07 30.0 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EWC48410.1 - 1.2e-05 25.3 0.6 4.6e-05 23.4 0.6 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3089 PF11288.8 EWC48410.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF915 PF06028.11 EWC48410.1 - 0.034 13.5 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Hydrolase_4 PF12146.8 EWC48410.1 - 0.043 13.1 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 COesterase PF00135.28 EWC48410.1 - 0.062 12.2 0.0 0.082 11.8 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family DUF2263 PF10021.9 EWC48411.1 - 2.1e-16 60.6 0.0 6.5e-16 59.0 0.0 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Mod_r PF07200.13 EWC48412.1 - 3.1e-19 69.5 0.0 4.1e-17 62.6 0.0 2.1 1 1 1 2 2 2 2 Modifier of rudimentary (Mod(r)) protein NARP1 PF12569.8 EWC48415.1 - 2.2e-178 594.4 16.0 6.8e-178 592.8 12.6 2.1 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_14 PF13428.6 EWC48415.1 - 1.7e-18 65.7 11.7 0.00044 20.8 0.0 10.1 8 2 2 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48415.1 - 2e-17 63.2 13.2 0.006 16.9 1.1 8.0 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48415.1 - 3.5e-17 62.7 18.0 1.5e-06 28.6 0.8 8.7 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48415.1 - 5.7e-15 54.1 27.2 8.2e-05 22.4 0.0 10.1 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 EWC48415.1 - 2.2e-14 52.6 15.8 7.3e-06 25.6 0.1 7.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EWC48415.1 - 8.8e-11 41.3 5.2 2.2e-05 24.0 0.0 5.4 5 0 0 5 5 5 2 TPR repeat TPR_9 PF13371.6 EWC48415.1 - 3.1e-10 40.0 9.0 0.00038 20.5 0.1 5.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EWC48415.1 - 7.5e-09 35.1 15.5 0.0025 17.9 0.0 8.1 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48415.1 - 4.9e-07 30.3 28.2 0.0024 18.5 0.3 8.0 9 1 1 10 10 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 EWC48415.1 - 5.3e-06 26.4 6.1 0.6 10.6 0.0 6.1 7 0 0 7 7 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC48415.1 - 1.6e-05 25.0 12.1 0.0028 17.9 0.7 5.6 5 2 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EWC48415.1 - 3.1e-05 23.7 6.6 0.22 11.6 0.0 6.2 5 1 0 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EWC48415.1 - 0.00048 20.2 3.2 0.85 9.7 0.1 4.1 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 EWC48415.1 - 0.00061 20.2 0.0 6.8 7.6 0.0 4.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EWC48415.1 - 0.0071 16.2 5.2 7.1 6.7 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat YcaO_C PF18381.1 EWC48415.1 - 0.068 13.1 0.4 0.34 10.8 0.1 2.3 2 0 0 2 2 2 0 YcaO cyclodehydratase C-terminal domain Rapsyn_N PF10579.9 EWC48415.1 - 0.11 12.6 1.4 0.68 10.1 0.1 3.1 4 0 0 4 4 3 0 Rapsyn N-terminal myristoylation and linker region TPR_21 PF09976.9 EWC48415.1 - 0.12 12.1 20.4 1.2 8.8 0.4 4.4 5 1 1 6 6 4 0 Tetratricopeptide repeat-like domain U79_P34 PF03064.16 EWC48415.1 - 0.21 10.9 3.4 0.51 9.7 3.4 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 TPR_3 PF07720.12 EWC48415.1 - 1.1 9.4 7.0 9.1 6.4 0.1 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EWC48415.1 - 1.4 9.7 26.5 1 10.1 0.1 8.1 10 0 0 10 10 7 0 Tetratricopeptide repeat Fapy_DNA_glyco PF01149.24 EWC48416.1 - 1.7e-32 112.5 0.1 3.7e-32 111.4 0.1 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EWC48416.1 - 4.1e-16 58.7 0.0 1.1e-15 57.3 0.0 1.8 1 1 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Cwf_Cwc_15 PF04889.12 EWC48416.1 - 0.0077 16.0 12.9 0.013 15.3 12.9 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein ORC6 PF05460.13 EWC48416.1 - 0.066 12.5 11.5 0.089 12.0 10.5 1.6 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) TFIIE-A_C PF11521.8 EWC48416.1 - 0.35 11.2 19.6 0.56 10.5 2.3 2.9 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha CDC27 PF09507.10 EWC48416.1 - 0.52 9.6 24.6 0.68 9.3 24.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GP67 PF17634.2 EWC48416.1 - 0.56 10.7 15.7 1.7 9.1 1.6 2.6 2 0 0 2 2 2 0 Gene product 67 PBP1_TM PF14812.6 EWC48416.1 - 0.75 10.2 28.2 0.053 13.9 10.2 2.8 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIF_alpha PF05793.12 EWC48416.1 - 1.9 7.0 26.1 2.9 6.4 26.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SAPS PF04499.15 EWC48416.1 - 3 6.5 5.2 3.7 6.2 5.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AdoHcyase PF05221.17 EWC48417.1 - 6.3e-130 432.7 0.0 8.6e-73 245.1 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EWC48417.1 - 3.9e-84 280.6 4.5 7.2e-84 279.8 4.5 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EWC48417.1 - 5.7e-09 35.6 0.3 1.1e-08 34.6 0.3 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EWC48417.1 - 0.00051 19.7 0.5 0.00089 18.9 0.5 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ELFV_dehydrog PF00208.21 EWC48417.1 - 0.055 13.2 0.2 0.088 12.5 0.2 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DASH_Dad1 PF08649.10 EWC48418.1 - 4.4e-24 84.4 0.4 5.1e-24 84.2 0.4 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 Cid2 PF09774.9 EWC48420.1 - 1.5e-44 152.3 0.1 1.9e-44 151.9 0.1 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Cas_Cas2CT1978 PF09707.10 EWC48420.1 - 0.078 13.1 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) TPR_9 PF13371.6 EWC48421.1 - 7.6e-07 29.2 0.2 0.00067 19.7 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48421.1 - 1.8e-06 28.4 3.6 0.56 10.8 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48421.1 - 6.9e-06 26.6 8.2 0.0054 17.3 0.0 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EWC48421.1 - 1e-05 26.0 8.9 8.2 7.6 0.4 5.9 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48421.1 - 1.6e-05 24.7 0.1 0.31 11.2 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EWC48421.1 - 0.00023 21.0 1.3 0.81 9.9 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48421.1 - 0.00052 20.3 0.3 6.5 7.1 0.1 4.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC48421.1 - 0.0015 18.3 0.0 1.7 8.6 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EWC48421.1 - 0.0057 16.8 0.0 0.16 12.2 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 EWC48421.1 - 0.044 13.9 0.0 0.82 9.8 0.0 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 EWC48421.1 - 0.095 12.4 0.0 7.5 6.3 0.0 3.2 3 0 0 3 3 3 0 TPR repeat TPR_6 PF13174.6 EWC48421.1 - 1.1 10.0 5.3 74 4.3 0.0 4.6 6 1 0 6 6 5 0 Tetratricopeptide repeat RWD PF05773.22 EWC48422.1 - 2e-22 79.6 0.2 3.3e-22 79.0 0.2 1.3 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EWC48422.1 - 0.00014 22.3 6.6 0.0002 21.8 5.3 2.0 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 Aminotran_3 PF00202.21 EWC48423.1 - 7.9e-80 268.5 0.0 9.9e-80 268.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans PF04082.18 EWC48424.1 - 3.7e-17 62.2 0.0 3.2e-16 59.2 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48424.1 - 5e-06 26.5 5.7 8.3e-06 25.8 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LTXXQ PF07813.12 EWC48424.1 - 0.1 13.3 0.2 0.26 12.0 0.2 1.6 1 0 0 1 1 1 0 LTXXQ motif family protein zf-C2HC5 PF06221.13 EWC48424.1 - 0.38 10.8 3.2 0.88 9.6 3.2 1.5 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Synaptobrevin PF00957.21 EWC48426.1 - 1.9e-14 53.2 0.6 3e-14 52.6 0.6 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EWC48426.1 - 2.7e-10 40.1 0.0 6.8e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Regulated-SNARE-like domain GAT PF03127.14 EWC48426.1 - 0.064 13.6 1.0 0.23 11.8 1.0 1.9 1 1 0 1 1 1 0 GAT domain 2-Hacid_dh_C PF02826.19 EWC48427.1 - 2e-54 183.6 0.0 2.8e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EWC48427.1 - 6.6e-15 55.0 0.0 8.9e-15 54.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EWC48427.1 - 0.013 15.6 0.1 0.028 14.6 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase CHASE2 PF05226.11 EWC48427.1 - 0.064 13.0 0.0 2.6 7.7 0.0 2.1 1 1 1 2 2 2 0 CHASE2 domain NB-ARC PF00931.22 EWC48427.1 - 0.077 12.2 0.1 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain GATase_6 PF13522.6 EWC48428.1 - 4.2e-16 59.3 0.0 9.9e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EWC48428.1 - 1.7e-13 50.5 0.0 3.5e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EWC48428.1 - 4.8e-06 26.2 0.0 9.4e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EWC48428.1 - 0.0022 17.0 0.0 0.0069 15.3 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferases class-II PRTase_2 PF15609.6 EWC48428.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase DNA_photolyase PF00875.18 EWC48428.1 - 0.16 11.9 0.0 0.38 10.7 0.0 1.6 1 1 0 1 1 1 0 DNA photolyase YchF-GTPase_C PF06071.13 EWC48429.1 - 1.8e-36 124.2 0.2 1.8e-36 124.2 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EWC48429.1 - 3.1e-16 59.5 0.0 2.7e-15 56.5 0.0 2.3 1 1 1 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 EWC48429.1 - 0.0011 19.0 0.1 0.0024 17.9 0.1 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EWC48429.1 - 0.0031 17.1 0.0 0.0062 16.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RPAP1_N PF08621.10 EWC48429.1 - 0.17 11.7 3.3 0.32 10.8 3.3 1.5 1 0 0 1 1 1 0 RPAP1-like, N-terminal Peptidase_C97 PF05903.14 EWC48430.1 - 1.7e-35 122.1 0.0 2.1e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EWC48430.1 - 0.17 12.2 0.1 0.28 11.5 0.1 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Inhibitor_I78 PF11720.8 EWC48431.1 - 1.6e-07 31.3 0.0 2e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 EWC48431.1 - 0.045 14.4 0.3 0.085 13.5 0.3 1.6 1 1 0 1 1 1 0 Potato inhibitor I family Ank_5 PF13857.6 EWC48432.1 - 8.1e-18 64.3 2.8 2.6e-12 46.7 0.1 5.9 5 1 1 6 6 6 2 Ankyrin repeats (many copies) VPS9 PF02204.18 EWC48432.1 - 2.5e-14 53.3 0.0 7.2e-14 51.9 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_2 PF12796.7 EWC48432.1 - 7.5e-14 52.1 0.1 1.1e-05 25.9 0.0 3.9 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC48432.1 - 2.8e-09 37.3 1.2 0.0095 16.5 0.0 6.3 5 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC48432.1 - 1e-05 25.5 0.1 10 7.0 0.1 5.9 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EWC48432.1 - 6.7e-05 23.2 0.1 0.11 13.0 0.2 4.3 4 0 0 4 4 4 1 Ankyrin repeat PX PF00787.24 EWC48432.1 - 0.0021 18.0 0.1 0.0075 16.2 0.1 2.0 1 0 0 1 1 1 1 PX domain Zn_clus PF00172.18 EWC48433.1 - 8.1e-08 32.3 10.2 1.3e-07 31.6 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CwfJ_C_1 PF04677.15 EWC48434.1 - 1.1e-30 106.0 0.0 1.8e-30 105.3 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EWC48434.1 - 1.6e-29 102.7 0.3 5.6e-29 100.9 0.3 2.0 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 ATP_bind_1 PF03029.17 EWC48435.1 - 5.8e-78 262.0 0.7 8.5e-78 261.5 0.1 1.5 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EWC48435.1 - 8.5e-06 25.4 0.0 0.0012 18.4 0.1 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EWC48435.1 - 4.6e-05 23.2 0.5 0.00015 21.5 0.0 2.1 3 1 0 3 3 2 1 AAA domain MeaB PF03308.16 EWC48435.1 - 5.5e-05 22.3 0.1 0.11 11.5 0.1 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 EWC48435.1 - 0.00015 21.4 0.0 0.00046 19.8 0.0 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 EWC48435.1 - 0.0011 18.6 0.0 0.003 17.2 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 EWC48435.1 - 0.0015 18.6 0.0 0.008 16.3 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EWC48435.1 - 0.0018 18.4 0.0 0.0046 17.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain Arf PF00025.21 EWC48435.1 - 0.002 17.6 0.0 1.5 8.2 0.0 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family AAA_22 PF13401.6 EWC48435.1 - 0.0029 17.9 0.0 0.014 15.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain PRK PF00485.18 EWC48435.1 - 0.0041 16.9 0.0 0.023 14.5 0.0 2.0 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 EWC48435.1 - 0.0055 16.6 0.0 0.0094 15.9 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Roc PF08477.13 EWC48435.1 - 0.0062 16.8 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EWC48435.1 - 0.01 15.4 0.0 0.12 11.9 0.0 2.5 3 0 0 3 3 3 0 Ferrous iron transport protein B NB-ARC PF00931.22 EWC48435.1 - 0.011 14.9 0.1 0.036 13.2 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 EWC48435.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EWC48435.1 - 0.014 15.2 0.1 0.34 10.8 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.6 EWC48435.1 - 0.015 15.8 0.2 5.2 7.5 0.3 2.3 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EWC48435.1 - 0.015 15.4 0.3 0.35 10.9 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 EWC48435.1 - 0.017 15.0 0.1 6.1 6.7 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase Thymidylate_kin PF02223.17 EWC48435.1 - 0.021 14.5 0.6 0.2 11.3 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase AAA_18 PF13238.6 EWC48435.1 - 0.022 15.3 1.4 0.055 14.0 0.0 2.3 2 1 0 2 2 1 0 AAA domain CLP1_P PF16575.5 EWC48435.1 - 0.022 14.5 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EWC48435.1 - 0.067 13.6 0.0 0.15 12.4 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain KAP_NTPase PF07693.14 EWC48435.1 - 0.067 12.4 0.7 0.59 9.3 0.7 2.1 1 1 0 1 1 1 0 KAP family P-loop domain AAA_7 PF12775.7 EWC48435.1 - 0.07 12.6 0.0 0.18 11.3 0.0 1.7 2 0 0 2 2 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EWC48435.1 - 0.073 12.8 0.1 0.44 10.3 0.0 2.3 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EWC48435.1 - 1.1 9.3 3.1 73 3.4 0.0 3.6 3 1 1 4 4 4 0 Dynamin family ATP11 PF06644.11 EWC48435.1 - 1.2 8.9 5.0 1.9 8.2 5.0 1.2 1 0 0 1 1 1 0 ATP11 protein GET2 PF08690.10 EWC48435.1 - 1.5 8.5 8.1 1.4 8.5 7.1 1.4 1 1 0 1 1 1 0 GET complex subunit GET2 PAF PF15715.5 EWC48435.1 - 1.6 9.3 7.6 3 8.4 7.4 1.6 1 1 0 1 1 1 0 PCNA-associated factor histone like domain TPR_14 PF13428.6 EWC48436.1 - 1.7e-23 81.3 21.1 0.0015 19.2 0.5 11.7 8 4 5 13 13 12 5 Tetratricopeptide repeat HAT PF02184.16 EWC48436.1 - 1.3e-22 79.4 65.0 1.5e-13 50.4 2.1 13.6 14 0 0 14 14 14 5 HAT (Half-A-TPR) repeat TPR_19 PF14559.6 EWC48436.1 - 2.4e-22 79.2 0.0 2.1e-07 31.4 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat Suf PF05843.14 EWC48436.1 - 1.2e-14 55.0 27.9 0.0011 19.0 0.5 7.3 3 3 4 8 8 8 5 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EWC48436.1 - 1.1e-12 47.4 0.2 0.00099 19.3 0.0 5.3 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48436.1 - 6.9e-10 38.3 6.4 0.09 12.9 0.0 8.1 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 EWC48436.1 - 2e-08 33.8 2.4 2.1 8.8 0.1 6.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48436.1 - 4.7e-08 33.5 3.9 1.4 9.6 0.1 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 EWC48436.1 - 5.5e-08 32.3 14.7 0.028 13.7 1.0 4.8 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48436.1 - 2.7e-05 24.4 6.3 2.2 8.7 0.0 6.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC48436.1 - 3.2e-05 23.6 2.8 5.8 6.9 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EWC48436.1 - 0.0004 19.6 18.5 0.31 10.1 1.7 4.7 3 3 2 5 5 5 4 NRDE-2, necessary for RNA interference Fis1_TPR_C PF14853.6 EWC48436.1 - 0.0024 17.9 1.4 15 5.8 0.0 5.0 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EWC48436.1 - 0.0062 17.1 18.4 14 6.6 0.0 8.0 8 1 1 9 9 8 0 Tetratricopeptide repeat SNAP PF14938.6 EWC48436.1 - 0.0091 15.5 0.1 0.21 11.0 0.0 3.1 3 1 0 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 EWC48436.1 - 0.19 11.8 10.9 3.5 7.9 0.0 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EWC48436.1 - 0.31 11.1 20.9 0.9 9.6 0.9 6.9 6 3 3 9 9 9 0 U3 small nucleolar RNA-associated protein 6 TPR_9 PF13371.6 EWC48436.1 - 0.37 11.0 8.6 2.1 8.5 0.4 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat AC_N PF16214.5 EWC48437.1 - 1.9 7.5 6.7 2.3 7.3 6.7 1.0 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region CFEM PF05730.11 EWC48438.1 - 0.095 12.8 11.4 0.17 12.0 11.4 1.4 1 0 0 1 1 1 0 CFEM domain Orthoreo_P10 PF07204.11 EWC48438.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 TMEM154 PF15102.6 EWC48438.1 - 0.6 10.0 6.5 0.06 13.2 0.9 2.2 2 1 1 3 3 3 0 TMEM154 protein family Goodbye PF17109.5 EWC48439.1 - 1.5e-08 35.1 2.3 2.4e-07 31.2 0.0 2.8 1 1 1 2 2 2 1 fungal STAND N-terminal Goodbye domain NACHT PF05729.12 EWC48439.1 - 0.00014 21.9 0.1 0.0012 18.7 0.1 2.5 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EWC48439.1 - 0.012 15.9 0.4 0.082 13.2 0.0 2.6 2 1 0 2 2 2 0 AAA domain PIF1 PF05970.14 EWC48439.1 - 0.073 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase RNA_helicase PF00910.22 EWC48439.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ZZ PF00569.17 EWC48439.1 - 0.17 11.7 4.9 0.4 10.5 4.9 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type Tim54 PF11711.8 EWC48440.1 - 1.9e-123 412.0 0.4 2.2e-123 411.8 0.4 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 JAB PF01398.21 EWC48441.1 - 1.6e-11 44.2 0.1 3.1e-11 43.3 0.1 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease VirK PF06903.12 EWC48441.1 - 0.093 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 VirK protein Pox_L5 PF04872.13 EWC48441.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Poxvirus L5 protein family AA_permease_2 PF13520.6 EWC48442.1 - 3.9e-45 154.4 42.1 4.9e-45 154.1 42.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EWC48442.1 - 7.9e-22 77.5 32.1 1.2e-21 76.9 32.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4029 PF13221.6 EWC48442.1 - 0.2 12.3 1.9 3.2 8.5 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4029) FOXP-CC PF16159.5 EWC48443.1 - 3.6e-08 33.9 5.6 0.00034 21.2 1.2 3.4 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2H2 PF00096.26 EWC48443.1 - 8.6e-08 32.2 13.4 2.8e-06 27.5 0.5 4.0 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC48443.1 - 1.1e-07 31.9 8.6 2.3e-06 27.7 1.1 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EWC48443.1 - 8.1e-06 25.7 2.0 0.0094 15.9 0.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EWC48443.1 - 1.9e-05 25.1 7.8 0.0012 19.5 0.4 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger SPAM PF02090.15 EWC48443.1 - 0.005 16.6 0.5 0.0079 16.0 0.5 1.2 1 0 0 1 1 1 1 Salmonella surface presentation of antigen gene type M protein zf-C2H2_jaz PF12171.8 EWC48443.1 - 0.031 14.6 3.6 1.6 9.1 0.2 3.6 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding SH3_6 PF12913.7 EWC48443.1 - 0.052 13.1 0.1 0.13 11.8 0.1 1.7 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) zf_ZIC PF18366.1 EWC48443.1 - 0.067 13.3 0.6 0.067 13.3 0.6 3.0 3 1 0 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_11 PF16622.5 EWC48443.1 - 0.11 12.3 1.2 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 EWC48443.1 - 0.16 11.7 2.8 0.54 10.1 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-met PF12874.7 EWC48443.1 - 0.5 10.8 2.3 8.6 6.9 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 EWC48443.1 - 4.5 7.6 7.5 6.7 7.1 0.4 2.5 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zap1_zf2 PF18217.1 EWC48443.1 - 5.4 7.1 11.7 11 6.1 3.2 2.6 2 0 0 2 2 2 0 Zap1 zinc finger 2 adh_short PF00106.25 EWC48445.1 - 1.2e-53 181.5 1.0 1.6e-53 181.1 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48445.1 - 5.1e-38 130.9 3.5 6.4e-38 130.6 3.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC48445.1 - 3e-15 56.6 0.4 4.2e-15 56.1 0.4 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EWC48445.1 - 0.01 15.0 0.5 0.017 14.3 0.5 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EWC48445.1 - 0.016 14.7 0.2 0.027 13.9 0.2 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EWC48445.1 - 0.025 14.3 0.2 0.053 13.3 0.2 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.19 EWC48445.1 - 0.11 11.7 2.2 0.66 9.3 2.2 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pkinase PF00069.25 EWC48446.1 - 1.8e-61 207.8 0.4 1e-41 143.1 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48446.1 - 1.5e-27 96.5 0.4 5.3e-21 75.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EWC48446.1 - 1.5e-06 27.4 0.1 2e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EWC48446.1 - 0.00072 19.6 0.1 0.15 11.9 0.2 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EWC48446.1 - 0.0029 17.0 0.4 0.0071 15.7 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EWC48446.1 - 0.096 12.0 0.0 0.29 10.4 0.0 1.7 1 1 0 1 1 1 0 Kinase-like PA28_alpha PF02251.18 EWC48446.1 - 0.1 12.7 0.2 0.83 9.7 0.0 2.3 2 0 0 2 2 2 0 Proteasome activator pa28 alpha subunit Seadorna_VP7 PF07387.11 EWC48446.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Ribosomal_S11 PF00411.19 EWC48447.1 - 6.5e-12 45.8 0.1 1.1e-11 45.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S11 Kelch_6 PF13964.6 EWC48448.1 - 2.2e-06 27.8 6.3 0.016 15.5 0.0 4.8 4 1 1 5 5 5 2 Kelch motif TMEM154 PF15102.6 EWC48448.1 - 3.8e-05 23.6 0.2 8.7e-05 22.5 0.2 1.6 1 0 0 1 1 1 1 TMEM154 protein family Kelch_1 PF01344.25 EWC48448.1 - 0.00042 19.8 6.1 0.2 11.3 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EWC48448.1 - 0.0042 17.0 1.6 16 5.7 0.0 4.6 4 0 0 4 4 4 1 Kelch motif Podoplanin PF05808.11 EWC48448.1 - 0.0057 16.8 1.3 0.012 15.7 1.3 1.5 1 0 0 1 1 1 1 Podoplanin DUF4366 PF14283.6 EWC48448.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) RIFIN PF02009.16 EWC48448.1 - 0.012 15.5 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 Rifin Kelch_4 PF13418.6 EWC48448.1 - 0.016 15.2 4.8 0.77 9.8 0.0 4.5 5 0 0 5 5 5 0 Galactose oxidase, central domain DUF4064 PF13273.6 EWC48448.1 - 0.054 13.8 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) PfkB PF00294.24 EWC48448.1 - 0.094 12.0 0.0 0.26 10.6 0.0 1.7 2 0 0 2 2 2 0 pfkB family carbohydrate kinase TRP PF06011.12 EWC48448.1 - 0.15 10.8 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel zf-U1 PF06220.12 EWC48449.1 - 1.9e-07 30.8 0.4 3.9e-07 29.7 0.4 1.6 1 0 0 1 1 1 1 U1 zinc finger DUF2848 PF11010.8 EWC48449.1 - 0.14 11.8 0.0 0.49 10.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2848) Pre-PUA PF17832.1 EWC48450.1 - 6.7e-25 87.6 0.8 1.5e-24 86.4 0.8 1.6 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EWC48450.1 - 4.9e-16 58.5 0.0 1.7e-15 56.7 0.0 2.0 2 0 0 2 2 2 1 PUA domain CAP_GLY PF01302.25 EWC48451.1 - 7.7e-19 67.5 0.3 1.2e-18 66.8 0.3 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EWC48451.1 - 4.1e-10 39.7 1.8 0.12 12.9 0.2 4.8 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EWC48451.1 - 2.1e-06 27.4 3.4 0.029 14.1 0.5 4.0 3 2 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 EWC48451.1 - 6.7e-06 25.7 1.3 0.019 14.5 0.3 3.4 2 2 0 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EWC48451.1 - 0.00032 20.5 0.1 23 5.4 0.1 4.8 4 0 0 4 4 4 1 Leucine Rich repeat Ubiquitin_2 PF14560.6 EWC48451.1 - 0.013 15.9 0.0 0.11 12.9 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain Dor1 PF04124.12 EWC48451.1 - 0.026 13.2 0.1 0.043 12.5 0.1 1.3 1 0 0 1 1 1 0 Dor1-like family zf-C2H2 PF00096.26 EWC48452.1 - 4.8e-07 29.9 13.5 0.00057 20.2 2.0 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EWC48452.1 - 3.1e-06 27.4 0.6 3.1e-06 27.4 0.6 4.2 4 1 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EWC48452.1 - 7.4e-06 26.4 8.7 0.029 15.2 1.0 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EWC48452.1 - 0.14 12.0 4.0 0.14 12.0 1.8 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type Glycos_transf_3 PF00591.21 EWC48454.1 - 5.3e-63 213.0 0.0 6.6e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EWC48454.1 - 0.033 14.0 0.0 0.095 12.6 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Tim44 PF04280.15 EWC48455.1 - 6e-35 120.5 0.3 1.8e-34 119.0 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain DUF3347 PF11827.8 EWC48455.1 - 0.13 12.4 0.3 0.13 12.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) SGTA_dimer PF16546.5 EWC48456.1 - 4e-20 71.4 0.1 6.5e-20 70.7 0.1 1.3 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 EWC48456.1 - 6.7e-17 60.5 1.7 1.6e-07 30.8 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48456.1 - 7.7e-15 53.7 2.5 2e-06 27.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48456.1 - 4.8e-07 30.3 2.1 4.8e-07 30.3 2.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC48456.1 - 8.4e-07 29.3 2.4 0.34 11.9 1.2 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EWC48456.1 - 8.7e-07 28.5 4.6 4.2e-05 23.1 0.3 2.8 1 1 2 3 3 3 1 TPR repeat TPR_8 PF13181.6 EWC48456.1 - 4.3e-06 26.5 5.0 0.28 11.5 0.1 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat STI1 PF17830.1 EWC48456.1 - 1.6e-05 24.7 4.5 0.00014 21.7 3.5 2.4 2 0 0 2 2 2 1 STI1 domain TPR_12 PF13424.6 EWC48456.1 - 2.5e-05 24.5 3.4 6.4e-05 23.2 1.4 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48456.1 - 0.00028 21.3 4.4 0.0019 18.6 1.0 2.7 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EWC48456.1 - 0.00051 20.2 2.2 0.012 15.9 0.1 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat XPC-binding PF09280.11 EWC48456.1 - 0.0028 17.3 0.6 0.0061 16.3 0.6 1.6 1 0 0 1 1 1 1 XPC-binding domain TPR_7 PF13176.6 EWC48456.1 - 0.0039 17.1 0.3 0.22 11.6 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 EWC48456.1 - 0.0077 16.7 0.2 0.9 10.0 0.1 2.3 1 1 1 2 2 2 1 Bacterial transcriptional activator domain TPR_10 PF13374.6 EWC48456.1 - 0.013 15.4 4.3 1.1 9.2 0.5 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EWC48456.1 - 0.029 15.0 5.4 13 6.6 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 EWC48456.1 - 0.033 13.4 1.2 0.089 12.0 0.8 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 EWC48456.1 - 0.034 14.2 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat MIT PF04212.18 EWC48456.1 - 0.15 12.1 0.0 0.15 12.1 0.0 2.9 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain Wzy_C_2 PF11846.8 EWC48456.1 - 0.2 11.5 0.2 0.32 10.9 0.2 1.3 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal Aldo_ket_red PF00248.21 EWC48457.1 - 4.7e-71 239.4 0.0 5.3e-71 239.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_Tnp_1 PF01527.20 EWC48457.1 - 0.0023 18.2 0.0 1.8 8.9 0.1 2.6 1 1 1 2 2 2 2 Transposase Kri1 PF05178.12 EWC48458.1 - 0.0005 20.6 4.3 0.0016 19.0 4.3 1.8 1 0 0 1 1 1 1 KRI1-like family Cut8 PF08559.10 EWC48458.1 - 0.26 10.9 3.6 0.44 10.1 3.6 1.4 1 0 0 1 1 1 0 Cut8, nuclear proteasome tether protein GILT PF03227.16 EWC48459.1 - 9.3e-19 67.7 0.0 2.4e-18 66.3 0.0 1.7 2 0 0 2 2 2 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Aldedh PF00171.22 EWC48461.1 - 3.9e-122 408.1 0.0 4.4e-122 407.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EWC48461.1 - 0.0011 18.1 0.0 0.0019 17.3 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) CdiI_2 PF18593.1 EWC48461.1 - 0.094 13.4 0.3 1.3 9.7 0.0 2.2 2 0 0 2 2 2 0 CdiI immunity protein Clr2_transil PF16761.5 EWC48462.1 - 2.6e-12 47.4 0.0 5.3e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 Clr2 PF10383.9 EWC48462.1 - 4.2e-07 30.8 2.7 1.3e-06 29.2 0.0 2.9 2 1 0 2 2 2 1 Transcription-silencing protein Clr2 MarB PF13999.6 EWC48462.1 - 0.0097 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 MarB protein Fungal_trans PF04082.18 EWC48463.1 - 9.7e-22 77.3 0.1 1.1e-17 64.0 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48463.1 - 7.3e-07 29.2 13.1 1.2e-06 28.5 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EWC48463.1 - 0.0048 15.7 0.3 0.02 13.7 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain K_channel_TID PF07941.11 EWC48463.1 - 0.45 11.0 6.7 2.8 8.5 6.7 2.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain MGC-24 PF05283.11 EWC48463.1 - 1.6 9.2 5.2 1.6 9.1 3.4 1.9 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Pkinase PF00069.25 EWC48464.1 - 6.6e-26 91.3 0.0 1.1e-13 51.2 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48464.1 - 4e-14 52.5 0.0 7.6e-07 28.7 0.0 3.5 2 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EWC48464.1 - 0.0057 16.0 0.6 0.014 14.8 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_23 PF13489.6 EWC48465.1 - 3e-24 85.7 0.0 4.2e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC48465.1 - 6.8e-10 39.5 0.0 1.3e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC48465.1 - 2.4e-08 33.9 0.0 1.9e-07 31.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC48465.1 - 1.1e-07 32.5 0.0 4.9e-07 30.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC48465.1 - 7.8e-07 29.7 0.0 1.7e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EWC48465.1 - 0.0016 18.0 0.0 0.0034 16.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 EWC48465.1 - 0.0099 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EWC48465.1 - 0.019 14.7 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase PrmA PF06325.13 EWC48465.1 - 0.019 14.4 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EWC48465.1 - 0.051 12.9 0.0 0.12 11.7 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EWC48465.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase FtsJ PF01728.19 EWC48465.1 - 0.22 11.6 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Fungal_trans PF04082.18 EWC48466.1 - 4.2e-25 88.3 0.0 8e-25 87.4 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48466.1 - 9.3e-05 22.5 7.7 0.00016 21.7 7.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain E1-E2_ATPase PF00122.20 EWC48467.1 - 1.5e-43 148.5 0.4 3.4e-43 147.3 0.4 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EWC48467.1 - 2e-25 90.3 0.1 4.2e-25 89.3 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EWC48467.1 - 9.4e-06 25.5 0.0 0.0031 17.3 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HMG_box PF00505.19 EWC48468.1 - 4.1e-13 49.5 0.1 6.5e-13 48.9 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EWC48468.1 - 2.4e-09 37.7 0.1 3.6e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 HMG-box domain Hemerythrin PF01814.23 EWC48470.1 - 3.7e-12 47.0 0.8 7.1e-12 46.1 0.8 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF2573 PF10835.8 EWC48470.1 - 0.057 13.8 0.4 2.5 8.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2573) SesA PF17107.5 EWC48471.1 - 0.00021 21.5 0.0 0.00062 20.0 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF677 PF05055.12 EWC48471.1 - 0.1 11.5 1.6 0.19 10.6 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF677) RAP PF08373.10 EWC48471.1 - 0.14 12.3 0.3 0.32 11.1 0.3 1.6 1 0 0 1 1 1 0 RAP domain DUF1445 PF07286.12 EWC48472.1 - 1.8e-40 138.2 0.0 2.6e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) Peptidase_S8 PF00082.22 EWC48474.1 - 8.8e-15 54.7 1.8 3.6e-14 52.7 1.8 1.9 1 1 0 1 1 1 1 Subtilase family Chromo PF00385.24 EWC48476.1 - 0.045 13.7 0.2 0.045 13.7 0.2 3.2 3 2 0 3 3 3 0 Chromo (CHRromatin Organisation MOdifier) domain Nefa_Nip30_N PF10187.9 EWC48477.1 - 5.6e-27 94.2 5.3 5.6e-27 94.2 5.3 1.9 2 1 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 zf-C4H2 PF10146.9 EWC48477.1 - 0.00064 20.1 3.1 0.00097 19.5 3.1 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein Draxin PF15550.6 EWC48477.1 - 0.28 11.0 8.0 0.37 10.6 8.0 1.2 1 0 0 1 1 1 0 Draxin RTA1 PF04479.13 EWC48478.1 - 1.5e-64 217.4 5.3 1.5e-64 217.4 5.3 1.4 2 0 0 2 2 2 1 RTA1 like protein DUF4131 PF13567.6 EWC48478.1 - 0.0035 17.0 6.6 0.5 10.0 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4131) HSP70 PF00012.20 EWC48479.1 - 2.7e-12 45.7 0.1 5.4e-12 44.7 0.1 1.4 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EWC48479.1 - 0.049 12.5 0.2 0.15 10.8 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein Pcc1 PF09341.10 EWC48480.1 - 4.9e-25 87.5 0.4 5.7e-25 87.2 0.4 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 BAG6 PF12057.8 EWC48480.1 - 0.063 13.0 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 BCL2-associated athanogene 6 Abhydrolase_6 PF12697.7 EWC48481.1 - 1.4e-11 45.4 9.7 2e-11 44.9 9.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EWC48481.1 - 3.5e-05 23.6 0.0 8.6e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EWC48481.1 - 0.0054 16.0 0.0 0.0087 15.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Phosphoesterase PF04185.14 EWC48482.1 - 1.1e-34 120.3 0.6 4.8e-34 118.1 0.6 1.8 1 1 0 1 1 1 1 Phosphoesterase family DUF348 PF03990.14 EWC48482.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain Cu-oxidase_3 PF07732.15 EWC48483.1 - 5.3e-41 139.4 0.3 5.3e-41 139.4 0.3 2.5 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EWC48483.1 - 1.9e-35 121.6 4.6 7.6e-30 103.4 0.7 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EWC48483.1 - 6.6e-29 101.1 0.0 5.6e-28 98.1 0.0 2.4 3 0 0 3 3 3 1 Multicopper oxidase UQ_con PF00179.26 EWC48484.1 - 4.8e-42 142.9 0.0 5.5e-42 142.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EWC48484.1 - 0.0041 16.8 0.0 0.0049 16.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EWC48484.1 - 0.0095 15.8 0.1 0.019 14.8 0.0 1.5 2 0 0 2 2 2 1 UEV domain RWD PF05773.22 EWC48484.1 - 0.044 14.1 0.0 0.052 13.8 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF1713 PF08213.11 EWC48485.1 - 9.3e-13 47.9 21.5 1.7e-12 47.1 21.5 1.4 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Rrp15p PF07890.12 EWC48486.1 - 4.1e-22 78.9 1.4 4.7e-22 78.8 1.4 1.0 1 0 0 1 1 1 1 Rrp15p Fer2 PF00111.27 EWC48487.1 - 1.7e-12 47.1 1.1 2.2e-12 46.7 1.1 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain IF4E PF01652.18 EWC48488.1 - 3e-50 170.1 0.1 4.3e-50 169.6 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E MTHFR PF02219.17 EWC48489.1 - 1.2e-93 313.6 0.0 1.9e-93 312.9 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Ribosomal_L22 PF00237.19 EWC48490.1 - 4.6e-26 91.1 0.1 7.7e-26 90.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e LMWPc PF01451.21 EWC48491.1 - 1.7e-27 96.6 0.0 2e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Chitin_synth_1 PF01644.17 EWC48492.1 - 1.7e-73 246.0 0.0 2.5e-73 245.4 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EWC48492.1 - 1e-30 105.5 0.2 2.2e-30 104.4 0.2 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EWC48492.1 - 9.2e-23 80.6 2.1 2.4e-16 59.5 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EWC48492.1 - 2.6e-09 37.3 1.6 2.6e-09 37.3 1.6 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 IBR PF01485.21 EWC48493.1 - 3.7e-12 46.3 21.2 8.3e-10 38.7 6.2 5.9 4 2 1 5 5 5 2 IBR domain, a half RING-finger domain Nop10p PF04135.12 EWC48493.1 - 0.042 13.9 0.0 2.7 8.1 0.0 3.0 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family Pol_alpha_B_N PF08418.10 EWC48493.1 - 0.4 10.6 0.1 0.4 10.6 0.1 1.6 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal zf-RING_2 PF13639.6 EWC48494.1 - 2.2e-09 37.5 5.4 1.5e-08 34.8 1.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EWC48494.1 - 3.1e-09 37.0 2.3 6.4e-08 32.8 1.1 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EWC48494.1 - 1.5e-07 31.2 7.1 5.6e-07 29.3 1.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC48494.1 - 6.3e-07 29.2 0.0 1.5e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EWC48494.1 - 6.5e-07 29.0 5.3 0.001 18.7 0.2 3.1 3 0 0 3 3 3 2 RING-like zinc finger zf-RING_5 PF14634.6 EWC48494.1 - 1.4e-06 28.2 0.3 1.4e-06 28.2 0.3 2.3 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EWC48494.1 - 9.5e-05 22.2 0.8 9.5e-05 22.2 0.8 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EWC48494.1 - 0.00012 21.9 4.5 0.0002 21.2 1.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EWC48494.1 - 0.00057 19.5 0.8 0.00057 19.5 0.8 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EWC48494.1 - 0.00058 19.8 1.1 0.00058 19.8 1.1 3.0 2 1 1 3 3 3 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EWC48494.1 - 0.00092 19.2 0.4 0.0022 18.0 0.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PQ-loop PF04193.14 EWC48494.1 - 0.0095 15.7 0.3 0.017 14.9 0.3 1.4 1 0 0 1 1 1 1 PQ loop repeat Prot_ATP_OB_N PF17758.1 EWC48494.1 - 0.034 13.8 0.2 0.062 12.9 0.2 1.4 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain ThiG PF05690.14 EWC48494.1 - 0.081 12.2 0.9 0.12 11.7 0.9 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG FANCL_C PF11793.8 EWC48494.1 - 0.23 11.7 5.4 1.7 8.9 3.2 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 EWC48494.1 - 0.99 9.6 5.4 0.35 11.0 1.3 2.2 2 0 0 2 2 2 0 RING-variant domain CAP_C PF08603.11 EWC48495.1 - 5.1e-63 211.4 2.1 6.2e-63 211.1 2.1 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.19 EWC48495.1 - 6.5e-17 62.0 0.1 6.5e-17 62.0 0.1 1.8 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal TBCC PF07986.12 EWC48495.1 - 0.019 14.7 0.3 0.18 11.5 0.4 2.0 1 1 1 2 2 2 0 Tubulin binding cofactor C DUF4318 PF14201.6 EWC48495.1 - 0.11 13.0 0.1 4.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4318) BSP PF04450.12 EWC48498.1 - 3.2e-58 196.9 0.0 4.3e-58 196.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase of plants and bacteria MFS_1 PF07690.16 EWC48499.1 - 2.8e-26 92.3 30.1 4e-25 88.5 18.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DnaA_N PF11638.8 EWC48499.1 - 0.095 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 DnaA N-terminal domain DUF3180 PF11377.8 EWC48499.1 - 1.5 9.0 6.3 1.5 9.0 1.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) Glyco_hydro_16 PF00722.21 EWC48500.1 - 1.5e-07 31.1 0.0 3.5e-07 29.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 EWC48500.1 - 0.00069 18.1 0.2 0.06 11.7 0.1 2.2 1 1 1 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) XdhC_CoxI PF02625.16 EWC48501.1 - 0.23 11.7 0.7 16 5.8 0.0 3.1 3 1 0 3 3 3 0 XdhC and CoxI family TnpV PF14198.6 EWC48501.1 - 0.37 10.8 3.1 1.3 9.1 0.5 2.7 2 0 0 2 2 2 0 Transposon-encoded protein TnpV Ribosomal_L5_C PF00673.21 EWC48502.1 - 1.1e-26 92.8 0.0 1.7e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EWC48502.1 - 0.0028 18.0 0.0 0.0047 17.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 PLDc_2 PF13091.6 EWC48503.1 - 1.8e-15 57.0 0.0 2.3e-07 30.7 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EWC48503.1 - 9.5e-08 31.9 3.6 0.0061 16.7 1.1 3.1 2 1 0 2 2 2 2 Phospholipase D Active site motif PIP5K PF01504.18 EWC48504.1 - 1.7e-42 145.6 0.0 1.4e-40 139.3 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF3902 PF13042.6 EWC48504.1 - 0.053 13.1 0.1 0.083 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3902) PRK PF00485.18 EWC48505.1 - 2.3e-24 86.2 0.0 2.9e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EWC48505.1 - 0.0067 17.0 0.1 0.019 15.5 0.1 1.7 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EWC48505.1 - 0.021 14.5 0.1 4.4 7.0 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase DGC PF08859.11 EWC48505.1 - 0.034 14.3 0.2 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 DGC domain CoaE PF01121.20 EWC48505.1 - 0.046 13.4 0.5 6.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase Myotub-related PF06602.14 EWC48507.1 - 1.2e-150 501.4 0.0 1.4e-150 501.1 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 EWC48507.1 - 0.02 14.8 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF3156 PF11354.8 EWC48507.1 - 0.03 14.2 0.1 0.055 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3156) DSPc PF00782.20 EWC48507.1 - 0.035 13.9 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain NOA36 PF06524.12 EWC48507.1 - 0.5 9.6 2.2 0.87 8.9 2.2 1.3 1 0 0 1 1 1 0 NOA36 protein DUF3074 PF11274.8 EWC48508.1 - 8.5e-58 195.4 0.4 2e-57 194.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) START PF01852.19 EWC48508.1 - 0.038 13.4 0.0 0.37 10.2 0.0 2.2 2 0 0 2 2 2 0 START domain NACHT PF05729.12 EWC48509.1 - 2.9e-21 76.1 0.0 4.2e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EWC48509.1 - 0.014 15.6 0.0 0.071 13.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EWC48509.1 - 0.035 14.5 0.0 0.068 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF2192 PF09958.9 EWC48509.1 - 0.088 12.3 0.2 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2192) RNA_helicase PF00910.22 EWC48509.1 - 0.097 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EWC48509.1 - 0.15 12.4 0.0 0.33 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EWC48509.1 - 0.16 11.7 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain SesA PF17107.5 EWC48510.1 - 2.3e-36 124.7 0.1 3.1e-36 124.2 0.1 1.2 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Nab2 PF11517.8 EWC48510.1 - 0.0042 17.3 0.0 0.02 15.2 0.0 2.1 1 1 1 2 2 2 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) DUF4363 PF14276.6 EWC48510.1 - 0.0083 16.2 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4363) DUF758 PF05527.11 EWC48510.1 - 0.039 13.9 0.1 0.95 9.4 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF758) tRNA-synt_His PF13393.6 EWC48510.1 - 0.048 12.9 0.1 0.086 12.1 0.1 1.6 1 1 0 1 1 1 0 Histidyl-tRNA synthetase Cas_DxTHG PF09455.10 EWC48510.1 - 0.1 12.2 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family ACD PF16671.5 EWC48510.1 - 0.1 10.9 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 Actin cross-linking domain tRNA-synt_1c PF00749.21 EWC48510.1 - 0.13 11.2 0.1 0.16 10.9 0.1 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Bap31_Bap29_C PF18035.1 EWC48511.1 - 0.0013 18.6 8.7 0.0083 16.1 0.3 4.0 3 0 0 3 3 3 2 Bap31/Bap29 cytoplasmic coiled-coil domain Nucleolin_bd PF16725.5 EWC48511.1 - 0.0037 16.9 0.6 0.012 15.3 0.6 1.8 1 0 0 1 1 1 1 Nucleolin binding domain DUF1664 PF07889.12 EWC48511.1 - 0.036 14.1 0.5 0.036 14.1 0.5 4.3 3 1 3 6 6 6 0 Protein of unknown function (DUF1664) Mcp5_PH PF12814.7 EWC48512.1 - 7.4e-41 139.1 0.1 1.5e-40 138.1 0.1 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology IMCp PF12314.8 EWC48512.1 - 5.5e-09 36.2 228.1 0.0013 19.0 16.4 7.9 1 1 8 9 9 9 5 Inner membrane complex protein PH PF00169.29 EWC48512.1 - 0.0038 17.7 0.0 0.0067 16.9 0.0 1.4 1 0 0 1 1 1 1 PH domain WD40 PF00400.32 EWC48513.1 - 2.3e-07 31.4 10.4 7.6 7.6 0.1 7.4 7 0 0 7 7 7 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48513.1 - 0.0006 20.1 0.1 0.81 10.0 0.1 3.5 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EWC48513.1 - 0.096 13.2 2.9 8.8 7.0 0.0 4.1 4 0 0 4 4 4 0 PQQ-like domain Sec16_N PF12935.7 EWC48513.1 - 0.31 11.2 5.7 6.8 6.8 0.8 2.2 1 1 1 2 2 2 0 Vesicle coat trafficking protein Sec16 N-terminus SRF-TF PF00319.18 EWC48514.1 - 3.8e-21 74.3 0.1 5.2e-21 73.9 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DEAD PF00270.29 EWC48515.1 - 2.9e-37 128.1 0.1 4.6e-37 127.5 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EWC48515.1 - 5.7e-27 94.3 0.8 1.2e-23 83.6 0.1 2.8 4 0 0 4 4 4 2 Helicase conserved C-terminal domain ResIII PF04851.15 EWC48515.1 - 3e-10 40.4 0.0 6e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit YihI PF04220.12 EWC48515.1 - 0.34 10.6 2.0 0.31 10.7 0.3 1.8 2 0 0 2 2 2 0 Der GTPase activator (YihI) eIF-1a PF01176.19 EWC48516.1 - 2.4e-22 78.5 0.0 3.4e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 zf-C2H2_assoc PF16606.5 EWC48517.1 - 0.35 11.1 5.1 0.12 12.6 1.7 2.0 1 1 1 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers Ank_2 PF12796.7 EWC48518.1 - 1.3e-16 61.0 0.8 1.1e-07 32.4 0.3 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EWC48518.1 - 9.5e-13 48.1 2.2 0.00052 20.3 0.2 4.4 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EWC48518.1 - 1.9e-10 41.0 0.7 0.0092 16.5 0.1 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EWC48518.1 - 1.3e-06 28.6 3.4 2.2 8.9 0.1 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EWC48518.1 - 4e-06 26.7 1.7 0.43 11.3 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat Ferric_reduct PF01794.19 EWC48519.1 - 2.7e-15 56.6 11.5 7.3e-15 55.2 10.4 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component PIG-F PF06699.11 EWC48519.1 - 0.36 11.0 3.0 0.29 11.3 1.7 1.7 1 1 0 1 1 1 0 GPI biosynthesis protein family Pig-F Med15_fungi PF05397.12 EWC48520.1 - 7.3e-27 93.9 8.5 7.3e-27 93.9 8.5 8.9 7 1 1 8 8 8 1 Mediator complex subunit 15 KIX_2 PF16987.5 EWC48520.1 - 3.3e-15 55.9 0.9 3.3e-15 55.9 0.9 4.8 5 1 0 5 5 5 1 KIX domain Ribosomal_L7Ae PF01248.26 EWC48521.1 - 6.3e-27 93.1 0.7 9.6e-27 92.6 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Steroid_dh PF02544.16 EWC48521.1 - 1.3e-09 38.2 0.2 1.9e-09 37.7 0.2 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase IU_nuc_hydro PF01156.19 EWC48522.1 - 7.4e-41 140.7 0.0 8.3e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase KxDL PF10241.9 EWC48524.1 - 0.3 11.4 3.9 0.79 10.0 3.9 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein NOA36 PF06524.12 EWC48524.1 - 0.96 8.7 12.6 1.9 7.7 12.6 1.4 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EWC48524.1 - 1.1 9.7 16.9 7.2 7.1 15.4 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain YtxH PF12732.7 EWC48524.1 - 1.2 9.7 10.6 15 6.2 6.7 2.7 2 0 0 2 2 2 0 YtxH-like protein D123 PF07065.14 EWC48524.1 - 1.7 7.7 9.0 3.1 6.9 2.2 2.2 2 0 0 2 2 2 0 D123 DUF883 PF05957.13 EWC48524.1 - 5.3 7.7 8.7 3.7 8.2 2.6 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Ran_BP1 PF00638.18 EWC48525.1 - 3.8e-50 169.2 4.1 5.5e-50 168.7 4.1 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EWC48525.1 - 2.6e-05 24.1 1.0 0.00012 22.0 1.0 1.9 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 EWC48525.1 - 0.0012 19.1 0.3 0.0017 18.6 0.3 1.2 1 0 0 1 1 1 1 VID27 PH-like domain YEATS PF03366.16 EWC48526.1 - 3e-23 81.6 0.1 6e-23 80.6 0.1 1.5 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EWC48526.1 - 7.4e-08 32.5 0.2 1.3e-07 31.6 0.2 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Aminotran_1_2 PF00155.21 EWC48527.1 - 5.5e-61 206.7 0.0 7.2e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EWC48527.1 - 0.003 16.9 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EWC48527.1 - 0.0094 14.9 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 EWC48527.1 - 0.15 10.8 0.0 0.36 9.5 0.0 1.5 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.17 EWC48527.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Peptidase_M16_C PF05193.21 EWC48528.1 - 4.4e-45 153.9 0.0 7.6e-45 153.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EWC48528.1 - 6.6e-41 139.8 0.0 1.6e-40 138.5 0.0 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) SNF2_N PF00176.23 EWC48529.1 - 2.1e-72 243.8 0.0 3e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EWC48529.1 - 8.8e-22 76.9 0.0 1.7e-21 76.0 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EWC48529.1 - 4.6e-15 55.9 0.0 1.1e-14 54.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 EWC48529.1 - 4.3e-07 29.7 8.1 7.1e-07 29.0 8.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EWC48529.1 - 3.6e-06 27.1 0.0 8.5e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EWC48529.1 - 1.8e-05 24.5 3.7 4.5e-05 23.2 3.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EWC48529.1 - 5.5e-05 23.1 8.7 0.00012 22.0 8.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EWC48529.1 - 8.6e-05 22.3 9.7 0.00016 21.5 9.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EWC48529.1 - 0.0013 19.0 8.5 0.0029 17.9 8.5 1.6 1 0 0 1 1 1 1 Ring finger domain PLU-1 PF08429.11 EWC48529.1 - 0.0033 16.7 2.3 0.0071 15.6 2.3 1.5 1 0 0 1 1 1 1 PLU-1-like protein UBA_4 PF14555.6 EWC48529.1 - 0.015 15.1 0.4 0.055 13.3 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain zf-RING_UBOX PF13445.6 EWC48529.1 - 0.03 14.3 7.0 0.065 13.3 7.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EWC48529.1 - 0.68 10.1 6.9 1.3 9.2 6.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EWC48529.1 - 0.75 9.6 10.4 28 4.6 10.0 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DUF4112 PF13430.6 EWC48530.1 - 1.6e-34 118.3 0.7 2.1e-34 118.0 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DCP2 PF05026.13 EWC48531.1 - 1.2e-26 92.8 0.1 2.1e-26 92.1 0.1 1.4 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EWC48531.1 - 2.4e-15 56.7 0.1 4.5e-15 55.8 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain L51_S25_CI-B8 PF05047.16 EWC48532.1 - 8.3e-15 54.4 0.1 1.3e-14 53.8 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Phosducin PF02114.16 EWC48533.1 - 3.3e-18 65.6 0.2 1.6e-15 56.8 0.0 2.4 3 0 0 3 3 3 2 Phosducin Na_Ca_ex PF01699.24 EWC48534.1 - 4e-28 98.3 30.2 2.2e-18 66.7 12.0 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein MtrG PF04210.13 EWC48534.1 - 0.088 12.7 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G WD40 PF00400.32 EWC48535.1 - 2.9e-40 135.5 17.8 6.5e-06 26.8 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48535.1 - 1.3e-15 57.5 0.0 5.1e-05 23.5 0.1 4.7 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EWC48535.1 - 0.00029 20.8 0.0 0.38 10.6 0.0 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EWC48535.1 - 0.004 16.1 0.1 9.7 5.0 0.0 3.7 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EWC48535.1 - 0.037 12.5 0.0 0.19 10.2 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF977 PF06163.11 EWC48535.1 - 0.13 12.2 0.7 5.2 7.0 0.0 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF977) A_deaminase PF00962.22 EWC48536.1 - 5.5e-16 58.8 0.0 6.9e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase MDM10 PF12519.8 EWC48537.1 - 1.9e-147 491.9 2.3 1.2e-129 433.2 1.5 2.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 EWC48537.1 - 0.1 12.0 0.6 1.9 7.9 0.3 2.6 3 0 0 3 3 3 0 Eukaryotic porin RL10P_insert PF17777.1 EWC48538.1 - 2.5e-22 78.6 0.0 4.4e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EWC48538.1 - 2.6e-17 62.8 0.0 3.6e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 TIM PF00121.18 EWC48539.1 - 2.9e-83 279.0 0.0 3.4e-83 278.8 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase MukF_M PF17192.4 EWC48539.1 - 0.031 14.0 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 MukF middle domain Bestrophin PF01062.21 EWC48540.1 - 1.6e-58 198.4 0.0 1.9e-58 198.2 0.0 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF5326 PF17260.2 EWC48540.1 - 0.73 10.0 5.4 4.1 7.6 0.4 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5326) Aminotran_4 PF01063.19 EWC48541.1 - 2.8e-22 79.7 0.0 4.9e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Amino-transferase class IV FAP PF07174.11 EWC48541.1 - 0.055 12.9 4.6 0.082 12.4 4.6 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) TMEM171 PF15471.6 EWC48541.1 - 0.35 9.8 4.9 0.54 9.2 4.9 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 RCDG1 PF15725.5 EWC48541.1 - 2.8 8.4 8.3 1.7 9.1 4.9 2.2 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein AMP-binding PF00501.28 EWC48542.1 - 1.8e-39 135.6 0.0 2.5e-39 135.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EWC48542.1 - 5.9e-13 48.5 0.9 5.9e-13 48.5 0.9 2.5 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EWC48542.1 - 0.0045 17.9 0.0 0.015 16.3 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Uteroglobin PF01099.17 EWC48542.1 - 0.096 13.0 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 Uteroglobin family FHA PF00498.26 EWC48543.1 - 2.9e-16 59.6 0.1 4.5e-16 59.0 0.1 1.3 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EWC48543.1 - 1.5e-12 47.0 5.7 3.1e-12 46.0 5.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EWC48543.1 - 5.9e-07 29.7 9.2 9.5e-07 29.1 9.2 1.3 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 EWC48543.1 - 0.00097 19.4 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_2 PF13923.6 EWC48543.1 - 0.002 17.9 9.4 0.0034 17.2 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EWC48543.1 - 0.0024 17.9 1.5 0.0056 16.7 1.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EWC48543.1 - 0.0025 17.6 9.7 0.0041 17.0 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EWC48543.1 - 0.0083 16.4 5.5 0.018 15.3 5.5 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EWC48543.1 - 0.063 13.2 6.3 0.11 12.5 6.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain FYRN PF05964.14 EWC48543.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 F/Y-rich N-terminus zf-C3HC4_3 PF13920.6 EWC48543.1 - 0.53 10.2 6.6 0.88 9.5 6.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EWC48543.1 - 0.69 9.6 5.5 1.8 8.2 5.7 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EWC48543.1 - 6.6 6.8 10.5 15 5.7 10.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger COMPASS-Shg1 PF05205.12 EWC48544.1 - 1e-11 45.4 0.3 6.1e-11 42.9 0.3 2.0 1 1 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 ATP13 PF12921.7 EWC48545.1 - 4.1e-19 68.5 0.0 8.8e-19 67.5 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR_3 PF13812.6 EWC48545.1 - 6.3e-07 29.4 0.0 1.3e-05 25.2 0.0 2.5 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 EWC48545.1 - 2.7e-06 27.4 2.9 0.18 12.0 0.0 4.4 4 1 1 5 5 5 2 PPR repeat family PIG-L PF02585.17 EWC48546.1 - 3e-13 50.5 0.0 4.2e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF1704 PF08014.11 EWC48546.1 - 0.16 10.9 0.0 0.28 10.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1704) DUF4131 PF13567.6 EWC48547.1 - 0.067 12.8 2.0 5.9 6.5 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) TMEM154 PF15102.6 EWC48548.1 - 0.019 14.9 0.6 0.052 13.4 0.6 1.9 1 1 0 1 1 1 0 TMEM154 protein family Sporozoite_P67 PF05642.11 EWC48548.1 - 1.9 6.5 7.4 2.7 6.0 7.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Arrestin_C PF02752.22 EWC48549.1 - 2.4e-22 79.9 0.0 7.5e-21 75.0 0.0 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EWC48549.1 - 3.1e-09 37.0 0.0 0.00011 22.3 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain PTCB-BRCT PF12738.7 EWC48550.1 - 8.1e-40 134.6 0.7 1.5e-20 72.9 0.0 4.4 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 EWC48550.1 - 5.8e-34 116.3 0.3 2.8e-14 53.3 0.1 5.4 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EWC48550.1 - 9.2e-20 70.9 0.0 1.4e-06 28.6 0.0 5.0 5 0 0 5 5 5 3 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EWC48550.1 - 2.1e-08 34.1 0.0 0.00051 20.1 0.0 3.6 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EWC48550.1 - 2.3e-06 27.8 0.9 0.055 13.8 0.0 4.7 5 0 0 5 5 5 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EWC48550.1 - 0.00051 19.9 0.0 4.1 7.3 0.0 3.8 4 0 0 4 4 4 2 Regulator of Ty1 transposition protein 107 BRCT domain Cullin PF00888.22 EWC48551.1 - 8.2e-167 556.5 0.2 1.1e-166 556.1 0.2 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EWC48551.1 - 4.7e-24 84.2 1.4 1.2e-23 82.9 1.4 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain NAD_kinase PF01513.21 EWC48552.1 - 1.3e-71 241.2 0.0 2.2e-71 240.4 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase HAGH_C PF16123.5 EWC48552.1 - 6.5e-18 65.0 0.1 1.3e-17 64.1 0.1 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EWC48552.1 - 1.3e-14 54.7 1.4 1.8e-13 50.9 1.4 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EWC48552.1 - 0.00036 20.1 0.6 0.0036 16.8 0.8 2.4 2 1 0 2 2 2 1 Beta-lactamase superfamily domain BcrAD_BadFG PF01869.20 EWC48552.1 - 0.037 13.5 0.1 0.3 10.6 0.0 2.3 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family Thioredoxin_16 PF18569.1 EWC48552.1 - 0.11 12.6 0.0 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like domain Ead_Ea22 PF13935.6 EWC48552.1 - 0.12 13.0 0.1 0.6 10.8 0.0 2.1 2 0 0 2 2 2 0 Ead/Ea22-like protein Las1 PF04031.13 EWC48553.1 - 1.3e-47 161.8 0.4 3.3e-47 160.4 0.1 1.8 2 0 0 2 2 2 1 Las1-like MIS13 PF08202.11 EWC48553.1 - 0.057 12.7 0.1 0.098 11.9 0.1 1.4 1 0 0 1 1 1 0 Mis12-Mtw1 protein family DUF1656 PF07869.12 EWC48553.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) DUF3740 PF12548.8 EWC48553.1 - 0.45 10.9 3.4 3.4 8.1 0.2 2.9 2 1 1 3 3 3 0 Sulfatase protein IF4E PF01652.18 EWC48554.1 - 7.3e-39 133.1 0.3 1e-38 132.6 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E GDA1_CD39 PF01150.17 EWC48555.1 - 1.5e-104 350.0 0.0 1.8e-104 349.8 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family PUL PF08324.11 EWC48556.1 - 5.9e-51 173.3 0.1 7.8e-51 172.9 0.1 1.1 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EWC48556.1 - 9.2e-34 116.4 0.0 1.4e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 EWC48556.1 - 3.9e-16 58.9 0.0 6.9e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EWC48556.1 - 1.7e-06 27.6 0.0 2.8e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EWC48556.1 - 3.2e-05 24.4 0.1 0.00018 21.9 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 EWC48556.1 - 0.00062 19.7 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EWC48556.1 - 0.0011 19.0 0.0 0.0034 17.4 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_4 PF13462.6 EWC48556.1 - 0.0041 17.3 0.1 0.023 14.8 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EWC48556.1 - 0.0062 16.5 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family DUF2847 PF11009.8 EWC48556.1 - 0.0098 15.8 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2847) Redoxin PF08534.10 EWC48556.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Redoxin T4_deiodinase PF00837.17 EWC48556.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Iodothyronine deiodinase SpoU_methylase PF00588.19 EWC48557.1 - 2.5e-26 92.5 0.0 4.6e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family CAS_CSE1 PF03378.15 EWC48557.1 - 0.14 10.6 0.0 0.3 9.5 0.0 1.4 2 0 0 2 2 2 0 CAS/CSE protein, C-terminus UDG PF03167.19 EWC48559.1 - 1.9e-16 60.5 0.0 2.8e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Kinesin PF00225.23 EWC48560.1 - 5.4e-112 374.0 0.1 5.4e-112 374.0 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EWC48560.1 - 7.7e-25 87.6 0.8 2.1e-24 86.2 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Jnk-SapK_ap_N PF09744.9 EWC48560.1 - 0.095 12.9 11.9 0.23 11.7 11.9 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 EWC48560.1 - 0.35 9.7 16.0 0.41 9.5 15.0 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 EWC48560.1 - 0.51 8.2 9.4 0.86 7.4 9.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.14 EWC48560.1 - 1 9.2 9.5 13 5.6 9.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF812 PF05667.11 EWC48560.1 - 1.1 8.0 16.3 3.6 6.4 16.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF812) BPL_N PF09825.9 EWC48560.1 - 1.4 7.9 5.0 2.5 7.1 5.0 1.3 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Glyco_hydro_63N PF16923.5 EWC48560.1 - 1.4 8.9 6.0 2.4 8.2 2.4 2.3 1 1 1 2 2 2 0 Glycosyl hydrolase family 63 N-terminal domain NPV_P10 PF05531.12 EWC48560.1 - 1.6 9.3 4.7 8.8 6.9 4.7 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Vps16_N PF04841.13 EWC48561.1 - 5.5e-93 311.9 0.0 7.9e-93 311.4 0.0 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EWC48561.1 - 2e-90 303.1 0.0 2.7e-90 302.7 0.0 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 EWC48561.1 - 0.0025 18.1 0.2 2 8.8 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain IgGFc_binding PF17517.2 EWC48561.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 IgGFc binding protein Fungal_trans PF04082.18 EWC48562.1 - 3.4e-22 78.7 2.6 5.5e-22 78.1 2.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain RasGEF PF00617.19 EWC48563.1 - 7.6e-60 202.1 0.0 1.3e-59 201.4 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EWC48563.1 - 4e-26 91.3 0.3 7.6e-26 90.4 0.3 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EWC48563.1 - 9.8e-16 57.1 0.1 1.8e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC48563.1 - 2.3e-14 52.9 0.1 5.2e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EWC48563.1 - 4.1e-13 48.8 0.0 8.3e-13 47.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EWC48563.1 - 0.00078 19.5 0.0 0.0017 18.4 0.0 1.6 1 0 0 1 1 1 1 WW domain Amidohydro_1 PF01979.20 EWC48564.1 - 1.5e-46 159.3 0.0 1.5e-45 156.0 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EWC48564.1 - 1.1e-06 28.4 0.6 0.0021 17.6 0.3 2.5 2 1 0 2 2 2 2 Amidohydrolase family DUF1907 PF08925.11 EWC48564.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) GFO_IDH_MocA PF01408.22 EWC48565.1 - 6.3e-15 56.1 0.0 1.1e-14 55.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EWC48565.1 - 0.043 13.8 0.0 0.11 12.5 0.0 1.8 1 1 1 2 2 2 0 Oxidoreductase family, C-terminal alpha/beta domain DNMT1-RFD PF12047.8 EWC48567.1 - 4.1e-06 26.9 0.0 8.1e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain RBFA PF02033.18 EWC48567.1 - 0.032 14.7 0.0 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 Ribosome-binding factor A Ebp2 PF05890.12 EWC48568.1 - 5.1e-91 304.9 9.3 5.1e-91 304.9 9.3 2.2 2 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 BUD22 PF09073.10 EWC48568.1 - 0.0029 17.0 33.2 0.0029 17.0 33.2 2.2 2 0 0 2 2 2 1 BUD22 Tom22 PF04281.13 EWC48571.1 - 1.9e-47 160.5 0.2 2.4e-47 160.2 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Thioredoxin PF00085.20 EWC48572.1 - 1.3e-54 182.5 0.2 8.6e-28 96.4 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EWC48572.1 - 3.9e-16 59.7 0.5 9.1e-16 58.6 0.5 1.6 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EWC48572.1 - 7.1e-14 52.2 0.5 8.9e-06 26.1 0.0 2.8 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EWC48572.1 - 1.8e-13 50.5 0.0 1.7e-07 30.9 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EWC48572.1 - 4.4e-10 39.5 0.2 0.00024 21.0 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EWC48572.1 - 1.2e-09 38.2 0.0 0.00066 19.8 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 EWC48572.1 - 1.5e-08 34.8 0.0 0.0072 16.6 0.0 3.8 2 2 1 3 3 3 2 Thioredoxin-like Redoxin PF08534.10 EWC48572.1 - 7.7e-07 28.9 1.0 0.02 14.6 0.2 2.3 2 0 0 2 2 2 2 Redoxin ERp29_N PF07912.13 EWC48572.1 - 2.4e-06 27.7 0.2 0.0016 18.6 0.0 2.4 2 0 0 2 2 2 2 ERp29, N-terminal domain TraF PF13728.6 EWC48572.1 - 8.5e-06 25.7 0.0 0.04 13.7 0.0 2.2 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_6 PF13848.6 EWC48572.1 - 0.00054 19.9 0.0 3.4 7.6 0.0 3.2 2 1 1 3 3 3 2 Thioredoxin-like domain Glutaredoxin PF00462.24 EWC48572.1 - 0.0081 16.4 0.2 3.9 7.8 0.0 2.8 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_9 PF14595.6 EWC48572.1 - 0.021 14.6 0.0 5.2 6.8 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin HSBP1 PF06825.12 EWC48573.1 - 5.3e-09 35.8 0.2 7.7e-09 35.3 0.2 1.3 1 0 0 1 1 1 1 Heat shock factor binding protein 1 BLOC1_2 PF10046.9 EWC48573.1 - 0.0017 18.6 0.0 0.0022 18.3 0.0 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 HsbA PF12296.8 EWC48573.1 - 0.0055 17.1 1.4 0.0076 16.7 1.4 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A FUSC-like PF12805.7 EWC48573.1 - 0.0087 15.2 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 FUSC-like inner membrane protein yccS Baculo_PEP_C PF04513.12 EWC48573.1 - 0.024 14.7 0.1 0.03 14.4 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus CLZ PF16526.5 EWC48573.1 - 0.027 14.8 0.0 0.044 14.1 0.0 1.4 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels UPF0184 PF03670.13 EWC48573.1 - 0.045 14.1 0.9 4 7.9 0.0 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) Matrilin_ccoil PF10393.9 EWC48573.1 - 0.087 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF4449 PF14613.6 EWC48575.1 - 1.6e-59 200.6 6.8 1.6e-59 200.6 6.8 2.4 2 1 2 4 4 4 1 Protein of unknown function (DUF4449) Phage_lysozyme2 PF18013.1 EWC48575.1 - 0.032 14.2 2.2 0.042 13.9 0.6 2.0 2 0 0 2 2 2 0 Phage tail lysozyme DnaJ PF00226.31 EWC48577.1 - 1.8e-21 76.1 1.0 3.7e-21 75.0 0.3 2.0 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.22 EWC48577.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 EWC48577.1 - 0.099 12.5 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Ribosomal_L27A PF00828.19 EWC48578.1 - 4.4e-30 105.0 0.4 6.9e-30 104.4 0.4 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A FAM217 PF15344.6 EWC48578.1 - 0.014 15.3 0.9 0.029 14.3 0.9 1.4 1 0 0 1 1 1 0 FAM217 family LSM PF01423.22 EWC48579.1 - 8.4e-17 60.6 0.4 1.1e-16 60.2 0.4 1.2 1 0 0 1 1 1 1 LSM domain Porphobil_deam PF01379.20 EWC48581.1 - 1e-77 260.2 0.0 1.3e-77 259.9 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EWC48581.1 - 9.1e-16 58.0 0.2 2.2e-15 56.8 0.2 1.7 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain CBS PF00571.28 EWC48582.1 - 5.4e-21 74.8 7.9 3.6e-10 40.1 0.5 4.3 4 0 0 4 4 4 4 CBS domain IL32 PF15225.6 EWC48582.1 - 0.087 13.2 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Interleukin 32 HHH_9 PF17674.1 EWC48582.1 - 0.14 13.0 0.3 11 7.0 0.1 3.1 3 1 0 3 3 3 0 HHH domain vWA-TerF-like PF10138.9 EWC48583.1 - 3.5e-06 27.3 0.1 4.8e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EWC48583.1 - 0.059 13.6 0.2 0.13 12.6 0.2 1.5 1 1 0 1 1 1 0 von Willebrand factor type A domain GhoS PF11080.8 EWC48583.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Endoribonuclease GhoS Arm PF00514.23 EWC48585.1 - 1.6e-74 243.9 32.9 3.1e-12 46.1 0.1 11.6 11 1 1 12 12 12 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EWC48585.1 - 4e-21 75.1 18.2 2.8e-07 30.9 0.2 8.1 7 3 3 10 10 10 5 HEAT-like repeat HEAT_2 PF13646.6 EWC48585.1 - 7.6e-18 64.7 8.8 0.0019 18.5 0.0 7.4 4 2 3 7 7 7 4 HEAT repeats HEAT PF02985.22 EWC48585.1 - 2.1e-15 55.5 17.3 0.066 13.5 0.0 9.1 10 0 0 10 10 9 4 HEAT repeat Adaptin_N PF01602.20 EWC48585.1 - 1.1e-11 44.1 8.6 4.5e-08 32.1 0.2 3.1 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 EWC48585.1 - 3.6e-11 43.0 4.9 1.6e-07 31.1 1.8 2.6 1 1 1 2 2 2 2 Armadillo-like KAP PF05804.12 EWC48585.1 - 1.7e-09 36.4 0.2 2.9e-09 35.7 0.2 1.3 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 EWC48585.1 - 6.2e-09 35.6 1.9 0.00035 20.0 0.8 3.7 2 1 1 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 EWC48585.1 - 4.6e-06 26.8 6.6 0.0042 17.2 0.4 4.8 1 1 3 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF5578 PF17741.1 EWC48585.1 - 8.9e-06 25.3 4.8 0.52 9.7 1.1 4.6 3 1 1 5 5 5 2 Family of unknown function (DUF5578) DUF3361 PF11841.8 EWC48585.1 - 6.8e-05 22.9 9.2 0.16 11.9 0.1 4.4 3 1 1 5 5 5 2 Domain of unknown function (DUF3361) HEAT_PBS PF03130.16 EWC48585.1 - 0.0016 18.9 5.1 7.4 7.6 0.2 6.6 6 0 0 6 6 6 1 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.8 EWC48585.1 - 0.0026 17.9 4.3 19 5.4 0.0 5.0 4 1 3 7 7 6 0 V-ATPase subunit H IFRD PF05004.13 EWC48585.1 - 0.012 14.7 8.3 0.26 10.3 0.3 4.2 3 2 0 3 3 3 0 Interferon-related developmental regulator (IFRD) YqfD PF06898.11 EWC48585.1 - 0.014 14.2 0.0 0.25 10.1 0.0 2.2 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD Atx10homo_assoc PF09759.9 EWC48585.1 - 0.017 15.1 5.6 8.9 6.4 0.0 4.9 3 2 3 6 6 6 0 Spinocerebellar ataxia type 10 protein domain Sdh5 PF03937.16 EWC48585.1 - 0.024 14.6 0.0 0.67 10.0 0.0 2.9 3 0 0 3 3 3 0 Flavinator of succinate dehydrogenase Vac14_Fab1_bd PF12755.7 EWC48585.1 - 0.045 14.3 0.0 1.3 9.7 0.0 3.1 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region Vpu PF00558.19 EWC48585.1 - 0.085 12.6 0.3 0.085 12.6 0.3 2.0 2 0 0 2 2 2 0 Vpu protein Cas_Csx9 PF09658.10 EWC48585.1 - 0.1 11.8 0.0 9.1 5.4 0.0 2.6 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Csx9) UNC45-central PF11701.8 EWC48585.1 - 0.26 11.2 4.2 22 5.0 0.3 3.8 3 1 1 4 4 4 0 Myosin-binding striated muscle assembly central UPF0052 PF01933.18 EWC48586.1 - 2.6e-59 200.9 0.0 3.7e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 DUF1501 PF07394.12 EWC48586.1 - 0.2 10.7 0.0 0.3 10.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Apc13p PF05839.11 EWC48587.1 - 4.8e-28 97.2 0.4 5.9e-28 96.9 0.4 1.0 1 0 0 1 1 1 1 Apc13p protein Ribosomal_S14 PF00253.21 EWC48588.1 - 2.8e-14 52.6 4.4 3e-14 52.5 4.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Pro_isomerase PF00160.21 EWC48589.1 - 2.3e-49 167.7 0.3 4.8e-49 166.7 0.1 1.7 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 EWC48589.1 - 0.0046 17.1 0.0 0.015 15.4 0.0 1.9 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 EWC48589.1 - 0.0073 15.7 0.1 0.15 11.4 0.0 2.5 2 1 0 2 2 2 1 Rtf2 RING-finger Chs7 PF12271.8 EWC48590.1 - 2e-125 417.9 18.5 2.3e-125 417.7 18.5 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone MFAP1 PF06991.11 EWC48591.1 - 2.1e-33 116.0 6.4 6.1e-28 98.2 0.6 4.0 3 1 1 4 4 4 2 Microfibril-associated/Pre-mRNA processing TRAPP PF04051.16 EWC48592.1 - 1.6e-42 144.7 0.0 1.9e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Vert_HS_TF PF06546.11 EWC48593.1 - 0.22 11.1 0.1 0.32 10.6 0.1 1.2 1 0 0 1 1 1 0 Vertebrate heat shock transcription factor Glyco_transf_90 PF05686.12 EWC48594.1 - 6.3e-14 51.7 6.2 2.4e-12 46.5 2.0 3.8 2 1 0 2 2 2 2 Glycosyl transferase family 90 Alb1 PF09135.11 EWC48595.1 - 1.1e-17 64.8 6.4 1.6e-17 64.3 6.4 1.2 1 0 0 1 1 1 1 Alb1 UCH PF00443.29 EWC48596.1 - 1.6e-10 40.9 0.0 5.1e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Rox3 PF08633.10 EWC48596.1 - 0.1 12.9 1.4 0.21 11.9 1.4 1.5 1 0 0 1 1 1 0 Rox3 mediator complex subunit UCH PF00443.29 EWC48597.1 - 1.5e-09 37.8 0.0 1.9e-08 34.1 0.0 2.0 1 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EWC48597.1 - 0.00019 21.1 0.1 0.051 13.2 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PP2C PF00481.21 EWC48598.1 - 5.3e-64 216.3 0.3 7.3e-51 173.3 0.0 3.0 2 1 0 2 2 2 2 Protein phosphatase 2C 4HBT_3 PF13622.6 EWC48599.1 - 2.8e-12 47.4 0.8 2.4e-11 44.4 0.4 1.9 1 1 1 2 2 2 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EWC48599.1 - 4.4e-07 29.8 0.0 1.6e-05 24.8 0.0 2.7 2 1 0 2 2 2 1 Acyl-CoA thioesterase Cyclin PF08613.11 EWC48600.1 - 1.1e-14 55.1 0.0 1.9e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EWC48600.1 - 0.0025 17.5 0.2 0.0042 16.8 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain PGAP1 PF07819.13 EWC48601.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.8 EWC48601.1 - 0.059 12.6 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EWC48601.1 - 0.47 11.0 5.2 1.2 9.7 5.3 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family GCV_H PF01597.19 EWC48602.1 - 2.5e-39 133.9 0.4 3.1e-39 133.6 0.4 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 EWC48602.1 - 0.0012 18.6 0.2 0.0022 17.8 0.2 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 EWC48602.1 - 0.027 14.4 0.1 0.049 13.6 0.1 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Ribosomal_S6 PF01250.17 EWC48603.1 - 1.4e-20 73.3 0.0 1.7e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 RRM_1 PF00076.22 EWC48604.1 - 4.4e-59 196.2 0.0 3e-21 75.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC48604.1 - 4.5e-08 32.8 0.0 0.012 15.4 0.0 3.3 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EWC48604.1 - 9.1e-08 31.7 0.0 0.00017 21.2 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EWC48604.1 - 1.9e-06 27.7 0.1 1.5 8.9 0.0 3.5 3 0 0 3 3 3 3 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 EWC48604.1 - 0.00023 21.2 0.0 0.62 10.2 0.0 2.8 3 0 0 3 3 3 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_7 PF16367.5 EWC48604.1 - 0.0032 17.6 0.0 1.3 9.2 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif RRM_8 PF11835.8 EWC48604.1 - 0.0062 16.7 0.0 0.39 10.9 0.0 2.4 2 0 0 2 2 2 1 RRM-like domain Pyr_redox_2 PF07992.14 EWC48605.1 - 6e-55 186.5 0.1 1.1e-54 185.7 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EWC48605.1 - 3.9e-11 43.4 0.0 8.4e-10 39.1 0.1 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EWC48605.1 - 0.0014 18.0 1.7 0.6 9.3 0.1 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase PIF1 PF05970.14 EWC48606.1 - 1e-62 212.5 0.3 1.8e-46 159.0 0.1 2.2 1 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EWC48606.1 - 1.6e-22 80.1 0.0 3.6e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EWC48606.1 - 3.1e-10 40.6 0.1 1e-09 38.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain Herpes_Helicase PF02689.14 EWC48606.1 - 1.7e-05 23.0 0.5 0.0014 16.7 0.0 2.1 2 0 0 2 2 2 1 Helicase AAA_7 PF12775.7 EWC48606.1 - 2.8e-05 23.7 0.1 5.3e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 EWC48606.1 - 8.9e-05 22.8 0.0 0.00024 21.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EWC48606.1 - 9.6e-05 22.1 0.0 0.00025 20.8 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain NB-ARC PF00931.22 EWC48606.1 - 0.00021 20.6 0.1 0.00034 19.9 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 EWC48606.1 - 0.00025 21.5 0.0 0.00059 20.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EWC48606.1 - 0.00041 20.2 0.2 1.2 8.8 0.1 2.7 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EWC48606.1 - 0.0015 17.6 0.1 0.0025 16.9 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 EWC48606.1 - 0.0018 18.7 0.0 0.0046 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain PhoH PF02562.16 EWC48606.1 - 0.01 15.3 0.2 0.073 12.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein NACHT PF05729.12 EWC48606.1 - 0.013 15.4 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 EWC48606.1 - 0.015 15.3 0.1 0.073 13.1 0.1 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 EWC48606.1 - 0.023 14.0 0.0 0.046 12.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 EWC48606.1 - 0.029 14.9 0.0 0.11 13.1 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EWC48606.1 - 0.04 13.7 0.0 0.097 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TrwB_AAD_bind PF10412.9 EWC48606.1 - 0.041 12.8 0.1 0.092 11.6 0.1 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Sigma54_activat PF00158.26 EWC48606.1 - 0.046 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF5605 PF18310.1 EWC48606.1 - 0.049 13.5 0.3 0.12 12.3 0.0 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF5605) RsgA_GTPase PF03193.16 EWC48606.1 - 0.071 13.0 1.0 0.13 12.2 0.2 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_14 PF13173.6 EWC48606.1 - 0.074 13.1 0.0 0.3 11.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain SH3_13 PF18335.1 EWC48606.1 - 0.081 12.8 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain Membr_traf_MHD PF10540.9 EWC48606.1 - 0.11 12.7 0.3 0.87 9.7 0.0 2.3 2 0 0 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain FtsK_SpoIIIE PF01580.18 EWC48606.1 - 0.11 11.8 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family ATPase_2 PF01637.18 EWC48606.1 - 0.12 12.3 0.1 0.41 10.5 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea YjeF_N PF03853.15 EWC48607.1 - 5.5e-40 137.0 0.0 8.9e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EWC48607.1 - 7.4e-05 23.6 4.8 7.4e-05 23.6 4.8 2.4 2 2 0 2 2 2 1 FDF domain Hamartin PF04388.12 EWC48607.1 - 0.024 13.3 10.9 0.034 12.8 10.9 1.1 1 0 0 1 1 1 0 Hamartin protein Prefoldin_3 PF13758.6 EWC48608.1 - 0.036 14.1 0.2 0.036 14.1 0.2 2.0 2 0 0 2 2 2 0 Prefoldin subunit Tmemb_cc2 PF10267.9 EWC48608.1 - 0.054 12.6 0.2 0.07 12.3 0.2 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein IF-2B PF01008.17 EWC48609.1 - 3.8e-77 259.3 1.8 4.4e-77 259.1 1.8 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Med2 PF11214.8 EWC48610.1 - 0.037 14.2 0.1 0.068 13.3 0.1 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 CAF1-p150_C2 PF15539.6 EWC48610.1 - 1.3 8.4 3.9 8.9 5.7 0.0 2.3 2 0 0 2 2 2 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term DUF3439 PF11921.8 EWC48611.1 - 0.96 9.4 4.6 6.6 6.7 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Sporozoite_P67 PF05642.11 EWC48611.1 - 1.5 6.8 11.8 2.3 6.2 11.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AAA PF00004.29 EWC48612.1 - 3.1e-95 315.6 0.0 1.7e-47 161.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EWC48612.1 - 5.3e-24 83.8 2.7 2.8e-12 46.3 0.2 2.9 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EWC48612.1 - 3.7e-19 68.7 0.6 1.8e-18 66.5 0.6 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EWC48612.1 - 6e-15 55.8 0.1 2e-07 31.3 0.0 3.4 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EWC48612.1 - 3.6e-14 52.8 0.1 7.8e-06 25.7 0.0 3.3 3 2 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EWC48612.1 - 3.9e-12 46.5 0.0 2.5e-05 24.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 EWC48612.1 - 6.2e-12 46.2 0.0 0.0026 18.2 0.0 4.3 2 2 2 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 EWC48612.1 - 6e-11 42.5 0.5 2.4e-05 24.3 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 EWC48612.1 - 1.7e-09 37.3 0.2 5.5e-09 35.7 0.0 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 EWC48612.1 - 2.7e-09 36.7 0.0 0.0013 18.1 0.0 2.7 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EWC48612.1 - 2.8e-09 37.4 0.4 0.027 14.8 0.0 4.2 2 2 2 4 4 4 2 AAA domain Mg_chelatase PF01078.21 EWC48612.1 - 6.7e-08 32.2 0.4 0.0056 16.1 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EWC48612.1 - 4.1e-07 30.6 0.0 0.031 14.8 0.0 3.1 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 EWC48612.1 - 6.2e-07 29.3 0.0 0.02 14.6 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 EWC48612.1 - 7e-07 29.6 0.0 0.029 14.7 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EWC48612.1 - 1.8e-06 28.0 0.0 0.016 15.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EWC48612.1 - 2e-06 27.4 0.3 0.52 9.6 0.0 3.4 3 0 0 3 3 3 2 KaiC Vps4_C PF09336.10 EWC48612.1 - 2.8e-06 27.2 0.2 3.1e-05 23.9 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_25 PF13481.6 EWC48612.1 - 3.8e-06 26.6 3.4 0.18 11.4 0.0 4.2 3 2 1 5 5 5 1 AAA domain AAA_7 PF12775.7 EWC48612.1 - 4.3e-06 26.4 0.1 0.026 14.1 0.0 3.0 2 2 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 EWC48612.1 - 6.3e-06 26.0 0.0 0.13 11.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain Parvo_NS1 PF01057.17 EWC48612.1 - 1.5e-05 24.2 0.1 0.051 12.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 DUF815 PF05673.13 EWC48612.1 - 2.1e-05 23.8 0.0 0.014 14.6 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 EWC48612.1 - 2.4e-05 24.7 0.0 0.18 12.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EWC48612.1 - 3.4e-05 23.6 0.1 0.43 10.3 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain Bac_DnaA PF00308.18 EWC48612.1 - 5.3e-05 23.2 0.0 0.16 11.8 0.0 2.7 3 0 0 3 3 2 2 Bacterial dnaA protein AAA_17 PF13207.6 EWC48612.1 - 0.00011 22.6 0.1 0.6 10.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 EWC48612.1 - 0.0002 21.4 0.0 0.43 10.6 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EWC48612.1 - 0.00022 21.8 0.0 0.45 11.0 0.0 3.5 2 1 0 2 2 2 1 ABC transporter PhoH PF02562.16 EWC48612.1 - 0.00028 20.4 0.4 0.68 9.3 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein ResIII PF04851.15 EWC48612.1 - 0.0003 20.8 0.0 0.076 13.0 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit NACHT PF05729.12 EWC48612.1 - 0.0003 20.7 0.1 0.18 11.7 0.0 2.9 3 0 0 3 3 3 1 NACHT domain AAA_3 PF07726.11 EWC48612.1 - 0.00042 20.2 0.0 1.2 9.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EWC48612.1 - 0.00049 20.0 0.0 1.4 8.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EWC48612.1 - 0.00084 19.3 0.1 2.2 8.1 0.0 3.3 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EWC48612.1 - 0.00089 19.0 0.4 0.85 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EWC48612.1 - 0.0017 17.7 0.0 1.4 8.1 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 EWC48612.1 - 0.0033 16.6 0.0 1.1 8.4 0.0 3.0 4 0 0 4 4 3 1 NB-ARC domain Viral_helicase1 PF01443.18 EWC48612.1 - 0.0042 16.9 0.0 0.35 10.6 0.0 2.5 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EWC48612.1 - 0.0068 16.8 1.3 5.5 7.3 0.0 3.4 3 1 0 4 4 2 0 AAA domain NTPase_1 PF03266.15 EWC48612.1 - 0.0092 15.9 0.6 2.5 8.0 0.0 3.8 4 0 0 4 4 3 1 NTPase Zeta_toxin PF06414.12 EWC48612.1 - 0.011 15.0 0.3 5.8 6.1 0.0 2.8 3 0 0 3 3 2 0 Zeta toxin KAP_NTPase PF07693.14 EWC48612.1 - 0.013 14.8 0.3 0.84 8.8 0.0 2.9 2 2 1 4 4 4 0 KAP family P-loop domain IPT PF01745.16 EWC48612.1 - 0.017 14.5 0.0 2.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Sigma54_activ_2 PF14532.6 EWC48612.1 - 0.022 14.8 0.0 3.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Zot PF05707.12 EWC48612.1 - 0.039 13.6 0.0 2 8.0 0.0 3.1 3 1 0 3 3 2 0 Zonular occludens toxin (Zot) UFD1 PF03152.14 EWC48612.1 - 0.042 13.3 0.0 0.42 10.1 0.0 2.1 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 Cytidylate_kin PF02224.18 EWC48612.1 - 0.061 13.1 0.0 10 5.8 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase AAA_6 PF12774.7 EWC48612.1 - 0.064 12.2 0.3 9 5.1 0.0 2.5 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region AFG1_ATPase PF03969.16 EWC48612.1 - 0.065 12.1 0.0 9.3 5.0 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase TIP120 PF08623.10 EWC48613.1 - 1.3e-62 210.5 0.3 1.3e-62 210.5 0.3 3.9 5 0 0 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 EWC48613.1 - 1.7e-16 60.4 22.4 0.0038 17.6 0.1 9.4 8 2 2 10 10 10 7 HEAT repeats HEAT PF02985.22 EWC48613.1 - 7.7e-10 38.2 17.5 2.4 8.6 0.0 10.6 12 0 0 12 12 10 3 HEAT repeat HEAT_EZ PF13513.6 EWC48613.1 - 3.7e-08 33.7 30.0 1.4 9.6 0.0 12.5 13 1 1 14 14 13 3 HEAT-like repeat Cnd3 PF12719.7 EWC48613.1 - 1.8e-05 24.1 2.1 1.3 8.2 0.0 4.4 4 0 0 4 4 4 3 Nuclear condensing complex subunits, C-term domain Vac14_Fab1_bd PF12755.7 EWC48613.1 - 3e-05 24.5 0.5 0.85 10.3 0.0 4.6 4 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 EWC48613.1 - 0.00023 21.3 11.9 0.036 14.3 0.1 6.4 7 1 1 8 8 8 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 EWC48613.1 - 0.0013 18.8 8.0 0.04 13.9 0.1 5.4 5 2 1 6 6 6 1 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EWC48613.1 - 0.0064 16.4 7.7 2.7 7.9 0.3 5.6 4 1 2 6 6 6 1 Domain of unknown function (DUF3361) TetR_C_16 PF17920.1 EWC48613.1 - 0.039 14.2 6.6 6.6 7.0 0.1 4.1 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain TAF6_C PF07571.13 EWC48613.1 - 0.055 13.8 0.6 2 8.8 0.0 4.0 4 1 0 4 4 2 0 TAF6 C-terminal HEAT repeat domain RasGEF_N_2 PF14663.6 EWC48613.1 - 1.2 9.6 6.3 25 5.3 0.1 5.0 5 0 0 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain TFCD_C PF12612.8 EWC48613.1 - 6 6.7 6.9 1.7e+02 1.9 1.8 4.6 3 1 1 5 5 5 0 Tubulin folding cofactor D C terminal CDC27 PF09507.10 EWC48614.1 - 1.1 8.5 75.5 1.4 8.2 75.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Borrelia_P83 PF05262.11 EWC48614.1 - 6.7 5.1 47.9 9.3 4.6 47.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein SAM_1 PF00536.30 EWC48615.1 - 1.7e-15 57.2 0.1 2.9e-15 56.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EWC48615.1 - 3.4e-15 55.9 0.0 5.6e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EWC48615.1 - 3.9e-12 46.6 0.0 9.4e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_4 PF18017.1 EWC48615.1 - 0.0027 17.7 0.0 0.0049 16.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA PF00004.29 EWC48616.1 - 1.7e-06 28.5 1.2 9.4e-06 26.1 1.2 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EWC48616.1 - 0.0012 18.9 0.0 0.01 15.8 0.0 2.2 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EWC48616.1 - 0.0024 18.3 0.0 0.0058 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EWC48616.1 - 0.016 15.8 0.0 0.038 14.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain HxlR PF01638.17 EWC48616.1 - 0.045 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 HxlR-like helix-turn-helix T2SSE PF00437.20 EWC48616.1 - 0.084 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 EWC48616.1 - 0.11 11.7 0.1 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin DUF2075 PF09848.9 EWC48616.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 EWC48616.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EWC48616.1 - 0.16 12.3 0.1 0.64 10.3 0.1 2.0 1 1 0 1 1 1 0 AAA domain Utp8 PF10395.9 EWC48617.1 - 3.2e-10 39.2 0.0 3.1e-07 29.3 0.1 2.5 2 1 0 2 2 2 2 Utp8 family FNIP_N PF14636.6 EWC48618.1 - 3e-13 51.0 12.0 3.2e-10 41.2 0.0 4.2 3 2 1 4 4 4 2 Folliculin-interacting protein N-terminus FNIP_M PF14637.6 EWC48618.1 - 0.18 11.8 0.0 0.76 9.7 0.0 1.9 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain IML1 PF12257.8 EWC48619.1 - 1.5e-116 388.5 0.0 2.3e-116 387.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EWC48619.1 - 5.7e-24 84.0 0.7 1.2e-23 82.9 0.7 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RNA_pol PF00940.19 EWC48620.1 - 5e-182 605.3 0.0 7e-182 604.9 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EWC48620.1 - 6.5e-95 318.4 1.3 6.5e-95 318.4 1.3 1.7 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal NUC153 PF08159.12 EWC48621.1 - 5.3e-18 64.5 6.7 1.9e-12 46.7 0.3 3.7 3 0 0 3 3 3 3 NUC153 domain Nop53 PF07767.11 EWC48622.1 - 4.6e-101 339.1 23.3 6.1e-101 338.7 23.3 1.2 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF2052 PF09747.9 EWC48622.1 - 0.03 14.4 13.5 0.068 13.3 13.5 1.6 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CorA PF01544.18 EWC48622.1 - 0.45 9.8 4.5 1.2 8.4 3.8 1.9 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Repressor_Mnt PF11423.8 EWC48622.1 - 1.3 8.9 5.5 2.7 7.8 0.9 3.0 3 0 0 3 3 3 0 Regulatory protein Mnt SMC_ScpA PF02616.14 EWC48622.1 - 1.6 8.6 9.3 3 7.7 9.3 1.5 1 0 0 1 1 1 0 Segregation and condensation protein ScpA CDC45 PF02724.14 EWC48622.1 - 4.6 5.4 15.8 7 4.8 15.8 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EWC48622.1 - 5.3 6.7 10.8 14 5.4 10.8 1.8 1 0 0 1 1 1 0 FAM176 family NMD3 PF04981.13 EWC48623.1 - 1.2e-79 267.3 5.3 1.7e-79 266.7 5.3 1.2 1 0 0 1 1 1 1 NMD3 family Rad4 PF03835.15 EWC48623.1 - 0.0075 16.0 0.9 0.0075 16.0 0.9 1.7 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain HypA PF01155.19 EWC48623.1 - 1.1 9.3 5.6 7.1 6.7 0.2 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EWC48623.1 - 3.9 7.6 10.2 2.4e+02 1.8 10.2 2.5 1 1 0 1 1 1 0 Double zinc ribbon RRM_1 PF00076.22 EWC48624.1 - 2.2e-08 33.8 0.1 1.7e-06 27.8 0.0 2.6 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Big_8 PF17961.1 EWC48624.1 - 0.067 13.3 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial Ig domain CLTH PF10607.9 EWC48625.1 - 7.6e-33 113.5 0.0 1.1e-32 113.0 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EWC48625.1 - 2.1e-06 27.5 0.0 4.4e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 LisH PfkB PF00294.24 EWC48626.1 - 3.5e-14 52.8 0.0 5.9e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase PRK PF00485.18 EWC48627.1 - 6e-63 212.2 0.0 1e-62 211.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 EWC48627.1 - 2.9e-45 154.3 0.0 5.1e-45 153.5 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 EWC48627.1 - 1.1e-06 29.3 0.0 2.7e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EWC48627.1 - 4.7e-05 23.6 0.0 0.00018 21.7 0.0 2.0 3 0 0 3 3 3 1 AAA domain CPT PF07931.12 EWC48627.1 - 5.4e-05 23.1 0.0 0.00015 21.7 0.0 1.8 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 EWC48627.1 - 0.00034 21.0 0.3 0.011 16.2 0.3 2.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EWC48627.1 - 0.0017 17.7 0.0 0.0035 16.6 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Cytidylate_kin PF02224.18 EWC48627.1 - 0.029 14.1 0.0 0.38 10.5 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase CbiA PF01656.23 EWC48627.1 - 0.031 14.3 0.0 0.096 12.7 0.0 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 EWC48627.1 - 0.033 14.6 0.0 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 EWC48627.1 - 0.037 13.8 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EWC48627.1 - 0.065 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 EWC48627.1 - 0.069 13.4 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EWC48627.1 - 0.13 12.1 0.0 0.43 10.4 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF87 PF01935.17 EWC48627.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain ABC_tran PF00005.27 EWC48627.1 - 0.15 12.6 0.2 0.71 10.4 0.0 2.0 2 0 0 2 2 2 0 ABC transporter ETC_C1_NDUFA4 PF04800.12 EWC48628.1 - 4e-37 126.4 2.3 5.4e-37 125.9 2.3 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region F1F0-ATPsyn_F PF10791.9 EWC48629.1 - 8.7e-41 138.3 0.1 9.9e-41 138.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 EWC48629.1 - 0.00091 19.6 0.0 0.001 19.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f CENP-Q PF13094.6 EWC48630.1 - 0.05 13.8 4.6 0.14 12.4 4.6 1.7 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit CPSase_L_D2 PF02786.17 EWC48631.1 - 1.1e-114 381.3 0.8 5.6e-84 280.9 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EWC48631.1 - 1.9e-47 160.3 0.0 4.4e-47 159.1 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EWC48631.1 - 2.4e-46 157.9 0.0 3.1e-45 154.3 0.0 2.5 2 0 0 2 2 2 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 EWC48631.1 - 5.1e-46 156.4 0.0 1.1e-45 155.3 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EWC48631.1 - 2.7e-37 127.8 0.0 9.5e-37 126.1 0.0 2.0 2 0 0 2 2 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EWC48631.1 - 3.3e-30 105.2 0.0 8.9e-30 103.8 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Dala_Dala_lig_C PF07478.13 EWC48631.1 - 2.1e-18 66.6 1.2 7.1e-10 38.8 0.2 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.22 EWC48631.1 - 8.2e-17 61.2 0.0 2.9e-16 59.4 0.0 2.1 1 0 0 1 1 1 1 MGS-like domain ATP-grasp PF02222.22 EWC48631.1 - 8.2e-16 58.0 0.3 3.7e-08 33.1 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EWC48631.1 - 1.6e-10 40.8 0.0 5e-05 23.0 0.0 3.3 3 0 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EWC48631.1 - 2.8e-05 24.0 0.3 0.0042 16.9 0.1 3.1 3 1 0 3 3 3 1 Peptidase C26 ATP-grasp_3 PF02655.14 EWC48631.1 - 4.3e-05 23.6 0.8 0.055 13.5 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 EWC48631.1 - 0.00019 21.1 0.1 0.011 15.4 0.1 2.5 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GARS_A PF01071.19 EWC48631.1 - 0.00022 21.1 0.5 0.1 12.3 0.1 3.1 3 1 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DJ-1_PfpI PF01965.24 EWC48631.1 - 0.00091 19.1 0.3 0.17 11.7 0.0 4.1 5 0 0 5 5 5 1 DJ-1/PfpI family Pex2_Pex12 PF04757.14 EWC48632.1 - 3.5e-55 187.0 6.4 4.2e-55 186.8 6.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EWC48632.1 - 1.9e-05 24.4 1.0 3.3e-05 23.7 1.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EWC48632.1 - 3.5e-05 23.6 0.2 5.2e-05 23.0 0.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EWC48632.1 - 4.2e-05 23.3 0.7 6.7e-05 22.7 0.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EWC48632.1 - 7.2e-05 22.9 2.5 0.00012 22.1 2.5 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EWC48632.1 - 0.0012 19.1 2.0 0.0019 18.5 2.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EWC48632.1 - 0.0033 17.4 2.1 0.0061 16.6 2.1 1.4 1 0 0 1 1 1 1 RING-type zinc-finger MT-A70 PF05063.14 EWC48633.1 - 3.3e-17 63.0 0.0 5.4e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 MT-A70 DUF202 PF02656.15 EWC48634.1 - 3.3e-16 59.5 0.6 3.3e-16 59.5 0.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) zf-LITAF-like PF10601.9 EWC48634.1 - 0.52 10.6 3.7 6.9 7.0 1.3 2.5 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain MatE PF01554.18 EWC48635.1 - 7.6e-62 207.7 24.3 4.6e-36 123.9 7.8 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EWC48635.1 - 0.00023 21.2 24.6 0.039 14.0 2.7 3.0 2 1 0 2 2 2 2 Polysaccharide biosynthesis C-terminal domain PsiE PF06146.12 EWC48635.1 - 0.24 11.8 0.1 0.24 11.8 0.1 1.9 2 0 0 2 2 2 0 Phosphate-starvation-inducible E RPN1_RPN2_N PF17781.1 EWC48636.1 - 6.3e-114 380.5 2.9 1.8e-113 379.0 2.9 1.7 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EWC48636.1 - 1.6e-28 98.5 0.0 2.9e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EWC48636.1 - 8.3e-21 73.3 15.0 5.8e-05 23.3 0.1 8.5 8 0 0 8 8 8 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EWC48636.1 - 3.7e-09 36.8 0.6 6e-05 23.3 0.0 4.2 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.22 EWC48636.1 - 0.013 15.7 0.0 37 4.9 0.2 3.9 3 0 0 3 3 3 0 HEAT repeat HEAT_EZ PF13513.6 EWC48636.1 - 0.12 12.9 0.1 0.62 10.6 0.1 2.4 1 0 0 1 1 1 0 HEAT-like repeat Nop14 PF04147.12 EWC48637.1 - 3.1e-05 22.4 10.8 5.3e-05 21.7 10.8 1.4 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 EWC48637.1 - 0.0051 16.3 14.0 0.0086 15.5 14.0 1.3 1 0 0 1 1 1 1 SDA1 PPP4R2 PF09184.11 EWC48637.1 - 0.13 11.9 10.2 0.21 11.1 10.2 1.3 1 0 0 1 1 1 0 PPP4R2 BUD22 PF09073.10 EWC48637.1 - 0.26 10.6 14.7 0.43 9.9 14.7 1.2 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 EWC48637.1 - 0.3 9.1 30.5 0.48 8.5 30.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.12 EWC48637.1 - 5.4 6.3 16.9 11 5.2 16.9 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Cnd2 PF05786.14 EWC48637.1 - 9.6 4.7 13.3 14 4.2 13.3 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 LAMTOR5 PF16672.5 EWC48638.1 - 3.5e-07 30.0 0.1 6.2e-07 29.3 0.1 1.4 1 1 0 1 1 1 1 Ragulator complex protein LAMTOR5 Kei1 PF08552.11 EWC48639.1 - 8.5e-59 198.6 0.1 1.1e-58 198.2 0.1 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Peptidase_M56 PF05569.11 EWC48639.1 - 0.041 13.1 0.6 0.15 11.2 0.6 1.7 1 1 0 1 1 1 0 BlaR1 peptidase M56 Methyltransf_11 PF08241.12 EWC48640.1 - 1.7e-19 70.2 0.0 3.7e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC48640.1 - 1.1e-18 67.4 0.0 1.6e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC48640.1 - 7.2e-18 65.1 0.0 2e-17 63.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EWC48640.1 - 1e-12 48.2 0.0 1.4e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC48640.1 - 3e-10 40.7 0.0 5.8e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC48640.1 - 6.8e-08 32.1 0.0 1.1e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EWC48640.1 - 6.2e-07 29.2 0.0 9.1e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EWC48640.1 - 0.0036 16.9 0.0 0.0064 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CheR PF01739.18 EWC48640.1 - 0.11 12.0 0.0 9.9 5.6 0.0 2.2 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Ribonuclease_3 PF00636.26 EWC48641.1 - 1.1e-38 132.0 0.0 3.1e-19 69.6 0.0 3.0 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EWC48641.1 - 1.3e-24 86.8 0.0 2.3e-11 43.9 0.0 3.5 2 1 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EWC48641.1 - 9.4e-24 83.4 0.0 7.6e-23 80.5 0.0 2.5 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 EWC48641.1 - 9.5e-19 67.8 0.1 2.9e-18 66.2 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC48641.1 - 3.5e-15 56.4 0.1 9.2e-15 55.1 0.1 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EWC48641.1 - 1.3e-10 41.3 0.0 2.8e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 EWC48641.1 - 2.9e-07 31.1 0.1 0.0071 17.0 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif DUF1067 PF06362.11 EWC48641.1 - 0.12 13.2 0.0 0.36 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1067) Myb_Cef PF11831.8 EWC48642.1 - 8.3e-50 169.6 1.0 8.3e-50 169.6 1.0 2.9 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EWC48642.1 - 5.5e-23 80.9 5.0 2.6e-11 43.5 0.8 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EWC48642.1 - 6.7e-21 74.3 4.3 3.4e-14 52.8 1.2 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EWC48642.1 - 0.0084 16.2 0.4 0.16 12.1 0.0 2.9 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain ParA PF10609.9 EWC48643.1 - 3.5e-93 311.6 0.0 4.1e-93 311.4 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EWC48643.1 - 6.8e-07 29.4 0.0 1.7e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EWC48643.1 - 0.00063 19.7 0.0 0.0024 17.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EWC48643.1 - 0.00077 18.7 2.4 0.0072 15.5 1.0 2.5 1 1 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.6 EWC48643.1 - 0.0037 17.1 0.1 0.14 12.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EWC48643.1 - 0.021 14.4 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 EWC48643.1 - 0.025 13.9 0.0 0.048 12.9 0.0 1.5 1 1 0 1 1 1 0 ATPase MipZ Fer4_NifH PF00142.18 EWC48643.1 - 0.025 14.0 0.0 0.5 9.8 0.0 2.4 2 1 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family RsgA_GTPase PF03193.16 EWC48643.1 - 0.038 13.9 0.1 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase TF_Zn_Ribbon PF08271.12 EWC48643.1 - 0.059 12.9 0.1 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding CBP_BcsQ PF06564.12 EWC48643.1 - 0.06 12.8 0.1 1.1 8.6 0.1 2.0 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 EWC48643.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_helicase PF00910.22 EWC48643.1 - 0.18 12.2 0.0 0.38 11.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.15 EWC48643.1 - 0.27 11.1 0.1 0.44 10.4 0.1 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain RNase_PH PF01138.21 EWC48644.1 - 1.5e-25 90.2 0.1 2.8e-25 89.4 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 TPR_14 PF13428.6 EWC48651.1 - 6.6e-15 54.5 6.6 4.5 8.3 0.3 11.0 9 2 3 12 12 11 2 Tetratricopeptide repeat Suf PF05843.14 EWC48651.1 - 5.5e-12 46.3 15.8 0.013 15.5 0.0 6.5 5 2 1 6 6 6 4 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 EWC48651.1 - 5.8e-07 29.5 19.9 0.27 11.2 0.1 7.9 5 1 3 8 8 8 3 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 EWC48651.1 - 7.1e-06 25.8 3.4 2.7 8.4 0.0 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 EWC48651.1 - 1.6e-05 24.2 4.0 0.00033 20.0 1.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48651.1 - 9e-05 22.7 4.9 25 5.2 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat RPN7 PF10602.9 EWC48651.1 - 0.00038 20.2 0.7 0.022 14.5 0.2 3.5 3 1 0 3 3 3 1 26S proteasome subunit RPN7 NRDE-2 PF08424.10 EWC48651.1 - 0.00043 19.5 13.1 0.021 14.0 0.1 5.5 2 2 4 6 6 6 2 NRDE-2, necessary for RNA interference TPR_2 PF07719.17 EWC48651.1 - 0.0021 18.0 15.8 2 8.7 0.0 8.0 11 0 0 11 11 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48651.1 - 0.0022 18.4 0.1 19 5.8 0.0 5.4 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EWC48651.1 - 0.0054 17.0 3.6 28 5.4 0.0 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TAtT PF16811.5 EWC48651.1 - 0.024 14.0 0.2 8.9 5.5 0.1 3.3 3 0 0 3 3 3 0 TRAP transporter T-component TPR_7 PF13176.6 EWC48651.1 - 0.082 13.0 5.2 33 4.8 0.0 5.6 7 0 0 7 7 6 0 Tetratricopeptide repeat MIT PF04212.18 EWC48651.1 - 0.11 12.6 0.0 2.2 8.4 0.1 3.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF1386 PF07138.11 EWC48651.1 - 0.12 11.6 0.1 4 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1386) TPR_10 PF13374.6 EWC48651.1 - 0.16 11.9 9.7 6.9 6.7 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EWC48651.1 - 0.17 11.8 0.4 10 6.1 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Cytochrom_C_2 PF01322.20 EWC48651.1 - 0.42 11.5 2.2 73 4.3 0.1 3.8 3 0 0 3 3 3 0 Cytochrome C' ATP-synt_D PF01813.17 EWC48652.1 - 6.1e-71 238.3 1.4 9.8e-71 237.7 1.4 1.3 1 0 0 1 1 1 1 ATP synthase subunit D SYCE1 PF15233.6 EWC48652.1 - 0.027 14.5 4.7 0.071 13.2 2.2 2.2 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 DUF3919 PF13057.6 EWC48652.1 - 0.059 12.9 1.7 0.086 12.4 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) DUF4795 PF16043.5 EWC48652.1 - 0.18 11.4 5.4 0.28 10.8 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Ribosomal_L6e PF01159.19 EWC48652.1 - 0.3 11.6 4.1 0.74 10.4 4.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L6e Pkinase PF00069.25 EWC48654.1 - 1.1e-61 208.5 0.0 1.9e-61 207.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48654.1 - 8.3e-35 120.3 0.0 2.1e-29 102.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EWC48654.1 - 2.2e-05 23.9 0.0 0.041 13.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EWC48654.1 - 0.00029 20.8 0.1 0.0005 20.1 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EWC48654.1 - 0.0091 15.0 0.0 0.017 14.1 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Dus PF01207.17 EWC48655.1 - 1.1e-48 166.0 0.0 8.7e-38 130.1 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EWC48655.1 - 0.0028 17.5 3.3 0.35 10.8 0.2 3.0 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EWC48655.1 - 0.0065 16.5 6.9 0.79 9.9 1.2 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EWC48655.1 - 0.0097 15.7 5.7 0.14 12.0 0.5 2.8 2 0 0 2 2 2 2 CCCH-type zinc finger Phospholip_A2_1 PF00068.19 EWC48655.1 - 0.27 11.7 1.8 1.8 9.0 0.6 2.3 2 0 0 2 2 2 0 Phospholipase A2 DUF2795 PF11387.8 EWC48657.1 - 9.7e-06 25.7 0.0 0.16 12.2 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF2795) DUF3682 PF12446.8 EWC48657.1 - 0.0017 18.8 2.0 0.0017 18.8 2.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3682) DASH_Dad3 PF08656.10 EWC48657.1 - 0.11 12.5 0.0 5.4 7.2 0.0 2.6 2 1 1 3 3 3 0 DASH complex subunit Dad3 Glyco_transf_28 PF03033.20 EWC48658.1 - 7.2e-16 58.5 0.0 2.3e-15 56.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EWC48658.1 - 0.003 16.4 0.1 0.0047 15.8 0.1 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 EWC48658.1 - 0.015 15.6 0.0 0.067 13.6 0.0 2.1 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain Glyco_tran_28_C PF04101.16 EWC48658.1 - 0.022 14.7 4.4 0.16 12.0 0.0 2.8 2 1 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain DUF445 PF04286.12 EWC48658.1 - 0.21 11.4 7.9 0.33 10.7 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) UIM PF02809.20 EWC48658.1 - 0.99 9.5 45.4 1.4 9.0 1.5 8.0 9 0 0 9 9 9 0 Ubiquitin interaction motif TMEM154 PF15102.6 EWC48659.1 - 6.4e-05 22.9 0.1 0.00017 21.5 0.1 1.7 1 0 0 1 1 1 1 TMEM154 protein family Alpha_GJ PF03229.13 EWC48659.1 - 0.00022 21.8 2.3 0.00092 19.8 2.3 2.0 1 0 0 1 1 1 1 Alphavirus glycoprotein J Glycophorin_A PF01102.18 EWC48659.1 - 0.00084 19.6 0.1 0.0023 18.1 0.1 1.7 1 0 0 1 1 1 1 Glycophorin A Mid2 PF04478.12 EWC48659.1 - 0.0083 16.0 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor stn_TNFRSF12A PF12191.8 EWC48659.1 - 0.037 14.2 0.1 0.15 12.3 0.1 2.0 1 1 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain EphA2_TM PF14575.6 EWC48659.1 - 0.053 14.4 0.0 0.18 12.7 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Herpes_gE PF02480.16 EWC48659.1 - 0.088 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Trp_oprn_chp PF09534.10 EWC48659.1 - 0.29 10.9 4.1 9.7 5.9 1.9 2.5 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PEMT PF04191.13 EWC48660.1 - 1.2e-56 189.7 13.2 1.8e-34 118.3 0.4 2.7 3 0 0 3 3 3 2 Phospholipid methyltransferase HECW_N PF16562.5 EWC48660.1 - 0.00097 18.9 0.2 0.003 17.3 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 EWC48660.1 - 0.0081 16.7 0.1 0.13 12.8 0.1 2.4 1 1 0 1 1 1 1 SKICH domain Fig1 PF12351.8 EWC48661.1 - 2.6e-18 66.6 7.0 5.2e-18 65.6 7.0 1.4 1 0 0 1 1 1 1 Ca2+ regulator and membrane fusion protein Fig1 DUF1974 PF09317.11 EWC48661.1 - 0.37 10.3 2.6 0.46 10.0 1.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) MS_channel PF00924.18 EWC48661.1 - 5.4 6.5 6.5 0.43 10.1 1.0 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel p450 PF00067.22 EWC48662.1 - 7.3e-36 123.9 0.1 9.4e-36 123.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.12 EWC48663.1 - 2.4e-28 98.2 0.3 4.4e-28 97.3 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC48663.1 - 1.8e-12 47.4 0.0 3.1e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EWC48663.1 - 5.9e-06 25.9 3.0 0.00033 20.2 3.0 3.0 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus JIP_LZII PF16471.5 EWC48663.1 - 0.21 11.8 0.0 0.38 11.0 0.0 1.3 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II RSN1_7TM PF02714.15 EWC48664.1 - 4.1e-93 311.7 21.9 4.1e-93 311.7 21.9 2.8 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EWC48664.1 - 2.1e-46 157.5 2.6 2.1e-46 157.5 2.6 2.9 4 1 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EWC48664.1 - 6.1e-36 124.3 0.3 8.9e-36 123.8 0.3 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EWC48664.1 - 3.2e-23 81.7 0.5 6.9e-23 80.6 0.5 1.6 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter TMEM65 PF10507.9 EWC48664.1 - 0.087 12.8 1.8 0.32 10.9 1.8 2.0 1 0 0 1 1 1 0 Transmembrane protein 65 PH_13 PF16652.5 EWC48664.1 - 0.17 11.7 0.2 0.32 10.8 0.2 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain zf-C2H2_4 PF13894.6 EWC48665.1 - 5.9e-06 26.7 13.2 0.013 16.3 1.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EWC48665.1 - 0.00048 20.3 5.1 0.067 13.3 0.3 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-H2C2_2 PF13465.6 EWC48665.1 - 0.0066 16.8 1.9 0.0066 16.8 1.9 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EWC48665.1 - 0.036 14.5 0.7 0.036 14.5 0.7 3.7 4 0 0 4 4 4 0 Zinc finger, C2H2 type DUF4719 PF15843.5 EWC48665.1 - 0.055 13.6 0.2 0.17 12.0 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4719) zf-C2H2_jaz PF12171.8 EWC48665.1 - 0.87 10.0 7.1 8.1 6.9 2.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Amidase PF01425.21 EWC48666.1 - 3.4e-73 247.1 0.2 1.8e-71 241.5 0.2 2.0 1 1 0 1 1 1 1 Amidase zinc-ribbons_6 PF07191.12 EWC48667.1 - 1.4 9.0 4.4 2.6 8.1 4.4 1.4 1 0 0 1 1 1 0 zinc-ribbons Pkinase_fungal PF17667.1 EWC48669.1 - 2.8e-131 438.0 0.0 3.4e-131 437.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EWC48669.1 - 5.8e-07 29.2 0.0 9.8e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain MauJ PF17419.2 EWC48669.1 - 0.0066 15.9 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Methylamine utilization protein MauJ Kdo PF06293.14 EWC48669.1 - 0.021 14.2 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EWC48669.1 - 0.09 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.7 EWC48671.1 - 5.3e-09 35.8 0.1 2.1e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 F-box-like AAA_18 PF13238.6 EWC48672.1 - 2.4e-08 34.6 0.0 1.6e-07 31.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EWC48672.1 - 2.6e-07 30.6 0.3 0.00063 19.5 0.0 2.1 2 0 0 2 2 2 2 Cytidylate kinase AAA_33 PF13671.6 EWC48672.1 - 1.6e-06 28.3 0.0 0.0083 16.3 0.0 2.1 2 0 0 2 2 2 2 AAA domain SKI PF01202.22 EWC48672.1 - 5.1e-06 26.7 0.0 0.0032 17.6 0.0 2.3 2 0 0 2 2 2 2 Shikimate kinase dNK PF01712.19 EWC48672.1 - 0.0016 18.3 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_17 PF13207.6 EWC48672.1 - 0.0034 17.8 0.3 0.24 11.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain IPT PF01745.16 EWC48672.1 - 0.053 12.9 0.0 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA PF00004.29 EWC48672.1 - 0.066 13.6 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CoaE PF01121.20 EWC48672.1 - 0.1 12.3 0.5 0.29 10.8 0.0 2.0 3 0 0 3 3 3 0 Dephospho-CoA kinase ADK PF00406.22 EWC48672.1 - 0.18 11.9 0.6 3.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Adenylate kinase Ank_2 PF12796.7 EWC48673.1 - 1.3e-71 237.2 1.7 1.3e-10 41.7 0.0 10.6 4 3 7 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC48673.1 - 4.9e-47 157.7 8.8 6.1e-05 23.5 0.0 15.5 9 4 8 17 17 17 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC48673.1 - 1.1e-37 123.7 12.4 0.00067 19.9 0.0 18.2 19 0 0 19 19 19 8 Ankyrin repeat Ank_5 PF13857.6 EWC48673.1 - 1e-36 124.5 18.7 3.4e-05 24.0 0.2 15.1 8 5 7 15 15 15 9 Ankyrin repeats (many copies) Ank PF00023.30 EWC48673.1 - 3.8e-30 103.0 16.6 0.0011 19.3 0.0 15.4 16 0 0 16 16 16 9 Ankyrin repeat Pyridox_oxase_2 PF12766.7 EWC48674.1 - 9.7e-21 74.3 0.0 1.6e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Jacalin PF01419.17 EWC48676.1 - 1.5e-05 24.9 0.1 0.043 13.7 0.0 2.9 2 0 0 2 2 2 2 Jacalin-like lectin domain F-box PF00646.33 EWC48676.1 - 0.021 14.7 0.4 0.062 13.2 0.4 1.8 1 0 0 1 1 1 0 F-box domain adh_short PF00106.25 EWC48677.1 - 2.1e-36 125.2 0.3 2.5e-36 125.0 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48677.1 - 1.1e-31 110.2 0.1 1.4e-31 109.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC48677.1 - 1e-09 38.5 2.3 4.1e-09 36.6 1.8 2.1 1 1 0 1 1 1 1 KR domain PDZ_1 PF12812.7 EWC48678.1 - 1.3e-28 98.8 0.0 7.8e-22 77.1 0.0 2.8 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 EWC48678.1 - 3.8e-14 53.8 0.0 1.1e-13 52.3 0.0 1.8 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 EWC48678.1 - 2.2e-10 40.2 0.0 0.056 13.3 0.0 4.8 5 0 0 5 5 5 3 PDZ domain PDZ_2 PF13180.6 EWC48678.1 - 2.9e-08 33.9 0.1 0.52 10.7 0.0 4.7 4 1 0 4 4 4 3 PDZ domain PDZ PF00595.24 EWC48678.1 - 0.0011 19.3 0.0 10 6.5 0.0 4.3 4 1 1 5 5 5 1 PDZ domain Peptidase_S46 PF10459.9 EWC48678.1 - 0.0076 14.9 0.3 0.012 14.3 0.3 1.2 1 0 0 1 1 1 1 Peptidase S46 Peptidase_S7 PF00949.21 EWC48678.1 - 0.2 11.5 0.8 0.44 10.4 0.8 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF3431 PF11913.8 EWC48679.1 - 1.2e-65 221.3 0.0 1.7e-65 220.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Response_reg PF00072.24 EWC48680.1 - 1.6e-20 73.4 0.1 3.3e-20 72.3 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EWC48680.1 - 1.4e-19 70.7 0.0 2.6e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EWC48680.1 - 4.1e-09 36.4 0.1 1.2e-08 34.9 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 EWC48680.1 - 2.7e-05 24.4 0.0 0.002 18.4 0.0 3.6 4 0 0 4 4 4 1 PAS fold PAS PF00989.25 EWC48680.1 - 0.0003 20.7 0.0 0.0014 18.7 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 EWC48680.1 - 0.00066 19.9 0.0 0.0022 18.2 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EWC48680.1 - 0.0032 17.4 0.0 0.032 14.3 0.0 2.4 2 0 0 2 2 2 1 PAS domain Senescence PF06911.12 EWC48681.1 - 1.9e-36 126.1 15.0 8.4e-22 78.4 3.4 2.5 1 1 1 2 2 2 2 Senescence-associated protein Acyl-CoA_dh_1 PF00441.24 EWC48682.1 - 2.3e-39 135.0 6.1 3.5e-39 134.4 6.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EWC48682.1 - 2.3e-23 82.2 0.0 4.3e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EWC48682.1 - 1.3e-19 70.9 0.2 3.4e-19 69.6 0.2 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EWC48682.1 - 9.4e-17 61.5 1.7 1.9e-16 60.6 1.7 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EWC48682.1 - 0.0027 17.4 0.0 0.0076 16.0 0.0 1.7 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal DUF4448 PF14610.6 EWC48683.1 - 1.1e-34 119.9 0.0 1.6e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SKG6 PF08693.10 EWC48683.1 - 0.043 13.2 0.9 0.097 12.1 0.9 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain ABC_membrane_2 PF06472.15 EWC48684.1 - 2.6e-87 292.6 0.1 4.6e-87 291.8 0.1 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EWC48684.1 - 1.2e-17 64.7 0.0 2.8e-17 63.5 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 EWC48684.1 - 4.8e-05 23.3 0.0 0.0001 22.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EWC48684.1 - 0.0088 15.8 0.1 0.053 13.3 0.0 2.3 3 0 0 3 3 3 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 EWC48684.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EWC48684.1 - 0.013 15.9 0.1 0.045 14.1 0.1 1.9 2 0 0 2 2 2 0 AAA ATPase domain End3 PF12761.7 EWC48684.1 - 0.014 15.6 0.2 0.027 14.6 0.2 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 SMC_N PF02463.19 EWC48684.1 - 0.05 13.0 1.0 0.13 11.7 0.1 2.0 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EWC48684.1 - 0.066 13.7 0.2 3.9 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4391 PF14335.6 EWC48684.1 - 0.17 11.6 0.2 0.26 11.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) APG6_N PF17675.1 EWC48684.1 - 0.25 11.9 1.6 0.48 10.9 1.6 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region ATP-synt_G PF04718.15 EWC48685.1 - 5.3e-29 101.0 0.3 8.1e-28 97.2 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Helicase_C PF00271.31 EWC48686.1 - 4.9e-27 94.5 0.0 4.7e-26 91.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EWC48686.1 - 1.8e-25 89.7 0.1 2.1e-16 60.2 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 EWC48686.1 - 1.3e-06 28.5 0.0 2.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit eIF-3c_N PF05470.12 EWC48686.1 - 5.9 5.1 5.8 1 7.6 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Fungal_trans PF04082.18 EWC48687.1 - 7.8e-38 130.0 0.0 1.3e-37 129.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48687.1 - 6.2e-09 35.8 8.0 1.1e-08 35.0 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Leptin PF02024.15 EWC48687.1 - 0.12 12.2 0.2 0.23 11.2 0.2 1.4 1 0 0 1 1 1 0 Leptin MFS_1 PF07690.16 EWC48688.1 - 6e-29 101.1 23.3 6e-29 101.1 23.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily TFCD_C PF12612.8 EWC48689.1 - 5e-25 88.4 0.0 2.1e-24 86.4 0.0 2.2 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal Vac14_Fab1_bd PF12755.7 EWC48689.1 - 1.3e-05 25.7 0.0 0.094 13.3 0.0 4.1 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EWC48689.1 - 1.8e-05 25.1 7.6 0.0035 17.8 0.1 5.3 5 1 1 6 6 6 2 HEAT-like repeat IFRD PF05004.13 EWC48689.1 - 0.0006 19.0 0.1 0.15 11.2 0.0 3.7 4 0 0 4 4 4 1 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 EWC48689.1 - 0.0031 17.9 2.2 0.16 12.4 0.1 4.4 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.22 EWC48689.1 - 0.023 14.9 16.1 0.12 12.7 0.3 7.5 9 0 0 9 9 9 0 HEAT repeat Metallophos PF00149.28 EWC48690.1 - 7.8e-28 98.4 0.0 2.1e-22 80.6 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EWC48690.1 - 0.11 12.9 0.6 0.35 11.3 0.6 1.9 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Hemerythrin PF01814.23 EWC48692.1 - 1.1e-11 45.4 6.2 1.9e-11 44.7 6.2 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF1104 PF06518.11 EWC48692.1 - 0.069 13.5 1.1 0.34 11.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) ThiF PF00899.21 EWC48694.1 - 1.5e-111 371.6 0.0 3.4e-73 246.0 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EWC48694.1 - 1.3e-89 300.4 0.0 2e-89 299.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EWC48694.1 - 2.2e-29 101.5 0.2 5.9e-29 100.1 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EWC48694.1 - 1.7e-28 99.1 0.0 3.6e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EWC48694.1 - 9.6e-27 93.0 0.0 2.6e-26 91.6 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle GST_N_2 PF13409.6 EWC48695.1 - 1.4e-22 79.7 0.0 2.8e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EWC48695.1 - 7.2e-14 51.6 0.0 1.3e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EWC48695.1 - 5.9e-08 32.8 0.0 1.3e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EWC48695.1 - 7.6e-05 22.8 0.0 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EWC48695.1 - 0.00011 22.5 0.0 0.053 13.9 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 EWC48695.1 - 0.0027 18.2 0.0 0.0052 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Neugrin PF06413.11 EWC48696.1 - 0.011 15.8 1.9 0.02 14.9 0.0 2.2 2 1 0 2 2 2 0 Neugrin DUF1643 PF07799.12 EWC48696.1 - 0.038 14.1 0.1 0.075 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) MRG PF05712.13 EWC48697.1 - 2e-50 170.8 2.5 2e-50 170.8 2.5 1.4 2 0 0 2 2 2 1 MRG Tudor-knot PF11717.8 EWC48697.1 - 2.8e-10 39.9 0.2 5.9e-10 38.9 0.2 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain GAS PF13851.6 EWC48697.1 - 0.051 12.9 3.7 1.2 8.4 2.3 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding AMP-binding PF00501.28 EWC48698.1 - 1.3e-82 277.7 0.0 1.6e-82 277.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC48698.1 - 1.3e-27 96.6 0.3 6.9e-26 91.0 0.3 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EWC48698.1 - 4.6e-19 68.1 0.0 1e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Reprolysin_5 PF13688.6 EWC48699.1 - 5.9e-52 176.7 2.4 5.9e-52 176.7 2.4 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EWC48699.1 - 4.9e-48 163.6 0.7 9.9e-48 162.6 0.7 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EWC48699.1 - 7.1e-46 156.4 0.7 1.1e-45 155.8 0.7 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 EWC48699.1 - 2e-14 54.1 26.0 2e-14 54.1 26.0 4.4 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 EWC48699.1 - 5.5e-13 49.5 0.0 1.9e-12 47.8 0.0 2.0 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 EWC48699.1 - 0.00016 21.6 6.6 0.0057 16.6 6.6 2.8 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Aminotran_1_2 PF00155.21 EWC48700.1 - 1.2e-68 232.0 0.0 1.4e-68 231.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EWC48700.1 - 0.072 12.0 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EWC48700.1 - 0.074 11.6 0.0 0.14 10.7 0.0 1.3 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Uds1 PF15456.6 EWC48701.1 - 1.1e-21 77.3 5.4 1.1e-21 77.3 5.4 2.7 3 0 0 3 3 3 1 Up-regulated During Septation MscS_porin PF12795.7 EWC48701.1 - 0.005 16.4 2.4 0.18 11.4 0.4 2.6 2 0 0 2 2 2 2 Mechanosensitive ion channel porin domain DUF1768 PF08719.11 EWC48702.1 - 3.8e-56 189.8 0.0 4.4e-56 189.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) HbrB PF08539.11 EWC48703.1 - 1.2e-47 162.0 0.4 2.8e-47 160.8 0.4 1.7 1 0 0 1 1 1 1 HbrB-like AAA_16 PF13191.6 EWC48703.1 - 2.1e-05 25.0 0.2 0.014 15.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EWC48703.1 - 0.0005 20.3 0.1 0.62 10.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EWC48703.1 - 0.005 16.8 0.1 5 7.0 0.0 2.7 3 0 0 3 3 3 2 ATPase domain predominantly from Archaea PRK PF00485.18 EWC48703.1 - 0.0099 15.6 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 EWC48703.1 - 0.032 14.5 0.2 0.1 12.8 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EWC48703.1 - 0.055 14.0 0.0 0.61 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EWC48703.1 - 0.088 12.5 0.2 0.17 11.6 0.2 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_23 PF13476.6 EWC48703.1 - 0.29 11.6 1.1 0.66 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain LSM PF01423.22 EWC48704.1 - 0.00035 20.2 0.0 0.00055 19.6 0.0 1.3 1 0 0 1 1 1 1 LSM domain Ribosomal_L3 PF00297.22 EWC48705.1 - 1.3e-183 610.1 6.5 1.5e-183 609.9 6.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 TPR_1 PF00515.28 EWC48706.1 - 7.3e-50 164.9 30.9 5.2e-08 32.4 0.1 10.5 11 1 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48706.1 - 4.7e-43 141.9 23.7 1.8e-05 24.5 0.0 10.4 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 EWC48706.1 - 1.5e-36 121.5 21.1 2.2e-07 30.5 0.0 10.6 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 EWC48706.1 - 1.5e-24 84.6 19.5 0.00058 20.1 0.0 9.6 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 EWC48706.1 - 1.3e-22 79.2 27.0 3.3e-06 26.7 0.2 9.8 6 2 3 9 9 9 5 TPR repeat TPR_12 PF13424.6 EWC48706.1 - 4.4e-22 78.2 17.7 3.5e-05 24.0 0.8 7.4 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.6 EWC48706.1 - 3.8e-21 74.0 9.7 0.0034 18.1 0.0 9.0 4 3 6 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48706.1 - 5.5e-21 74.8 15.0 0.0008 19.9 0.3 6.6 3 3 4 7 7 7 6 Tetratricopeptide repeat TPR_6 PF13174.6 EWC48706.1 - 6.7e-20 70.3 16.5 0.011 16.3 0.0 8.6 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48706.1 - 8.3e-20 71.2 10.2 0.00029 21.4 2.3 7.3 5 2 4 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EWC48706.1 - 1.5e-16 60.3 7.6 0.00075 19.6 0.1 6.9 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 EWC48706.1 - 3.8e-16 57.8 12.1 0.0091 16.0 0.1 8.7 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_15 PF13429.6 EWC48706.1 - 1.7e-10 40.6 9.0 0.0031 16.8 1.6 4.9 1 1 3 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EWC48706.1 - 2.2e-09 37.4 6.8 1.1e-07 31.9 1.3 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 EWC48706.1 - 6.9e-07 29.2 7.8 0.59 9.8 0.0 5.0 4 2 1 5 5 5 3 Tetratricopeptide repeat-like domain DUF2225 PF09986.9 EWC48706.1 - 0.0013 18.5 2.1 0.57 9.9 0.1 2.7 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) BTAD PF03704.17 EWC48706.1 - 0.0026 18.2 5.8 4.5 7.7 0.0 3.3 3 0 0 3 3 3 1 Bacterial transcriptional activator domain TPR_MalT PF17874.1 EWC48706.1 - 0.005 16.3 3.2 0.17 11.3 0.7 3.3 1 1 0 2 2 2 1 MalT-like TPR region TPR_20 PF14561.6 EWC48706.1 - 0.095 13.0 5.6 0.98 9.8 0.0 3.9 4 1 1 5 5 3 0 Tetratricopeptide repeat SNAP PF14938.6 EWC48706.1 - 0.2 11.0 15.6 11 5.4 0.3 4.9 2 2 1 3 3 3 0 Soluble NSF attachment protein, SNAP DUF2989 PF11207.8 EWC48706.1 - 0.25 11.1 2.6 1.1 9.0 0.5 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF2989) TPR_10 PF13374.6 EWC48706.1 - 1 9.3 18.3 15 5.6 0.0 7.3 9 0 0 9 9 9 0 Tetratricopeptide repeat DUF410 PF04190.13 EWC48706.1 - 1.1 9.0 4.8 4.2 7.1 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF410) Esterase_phd PF10503.9 EWC48707.1 - 9.8e-22 77.5 0.3 1.7e-21 76.7 0.3 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase CBM_1 PF00734.18 EWC48707.1 - 1.5e-10 40.8 9.3 1.5e-10 40.8 9.3 3.0 3 0 0 3 3 3 1 Fungal cellulose binding domain Peptidase_S9 PF00326.21 EWC48707.1 - 1.5e-06 27.9 1.5 1.5e-06 27.9 1.5 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Esterase PF00756.20 EWC48707.1 - 7e-05 22.6 0.6 0.00014 21.6 0.6 1.5 1 0 0 1 1 1 1 Putative esterase COesterase PF00135.28 EWC48707.1 - 0.00027 19.9 0.2 0.0008 18.4 0.2 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 EWC48707.1 - 0.0013 18.6 0.1 0.018 14.9 0.1 2.3 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EWC48707.1 - 0.0038 16.9 3.8 0.0085 15.8 3.8 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 EWC48707.1 - 0.0062 16.2 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Pox_A32 PF04665.12 EWC48707.1 - 0.022 14.3 0.0 0.03 13.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus A32 protein Abhydrolase_6 PF12697.7 EWC48707.1 - 0.044 14.4 0.1 0.058 14.0 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DLH PF01738.18 EWC48707.1 - 0.047 13.2 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EWC48707.1 - 0.067 12.4 0.0 4.2 6.6 0.0 2.3 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EWC48707.1 - 0.098 12.5 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Sporozoite_P67 PF05642.11 EWC48707.1 - 0.37 8.8 6.6 0.44 8.6 6.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TraG-D_C PF12696.7 EWC48707.1 - 3.2 7.8 5.8 8.3 6.4 0.0 2.4 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG SKN1 PF03935.15 EWC48708.1 - 1.2e-217 723.3 0.0 1.4e-217 723.0 0.0 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) NuiA PF07924.11 EWC48709.1 - 0.022 15.2 0.3 0.86 10.0 0.1 2.2 1 1 1 2 2 2 0 Nuclease A inhibitor-like protein IMS PF00817.20 EWC48711.1 - 4.3e-24 85.2 0.0 8.5e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EWC48711.1 - 4.5e-08 33.8 0.1 1.1e-07 32.6 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EWC48711.1 - 0.0046 17.2 0.1 0.012 15.9 0.1 1.7 1 0 0 1 1 1 1 IMS family HHH motif HAUS4 PF14735.6 EWC48712.1 - 8.7e-13 48.5 1.9 8.7e-13 48.5 1.9 1.6 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 4 DUF241 PF03087.14 EWC48712.1 - 0.021 14.7 7.0 0.05 13.4 4.5 2.5 2 1 0 2 2 2 0 Arabidopsis protein of unknown function BLOC1_2 PF10046.9 EWC48712.1 - 0.052 13.9 0.9 0.25 11.7 0.1 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 EWC48712.1 - 0.076 13.1 0.7 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) KxDL PF10241.9 EWC48712.1 - 0.6 10.4 0.1 0.6 10.4 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein THOC7 PF05615.13 EWC48712.1 - 0.72 10.1 9.2 7.1 6.9 4.4 2.9 2 1 0 2 2 2 0 Tho complex subunit 7 DUF4404 PF14357.6 EWC48712.1 - 1.1 9.9 9.3 1.9 9.2 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) SART-1 PF03343.13 EWC48713.1 - 6.5e-182 606.4 59.5 3.3e-173 577.7 56.3 2.0 2 0 0 2 2 2 2 SART-1 family CAP PF00188.26 EWC48713.1 - 0.0025 18.6 2.4 2.3 9.0 0.0 3.4 3 0 0 3 3 3 2 Cysteine-rich secretory protein family PTH2 PF01981.16 EWC48714.1 - 6.8e-47 158.6 0.4 8.4e-47 158.3 0.4 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Aminotran_1_2 PF00155.21 EWC48715.1 - 3.3e-85 286.4 0.0 3.8e-85 286.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II ILEI PF15711.5 EWC48715.1 - 0.028 14.9 0.0 0.44 11.0 0.0 2.3 2 0 0 2 2 2 0 Interleukin-like EMT inducer Hpt PF01627.23 EWC48716.1 - 1.2e-12 47.9 0.4 1.7e-12 47.4 0.1 1.5 2 0 0 2 2 2 1 Hpt domain ADP_ribosyl_GH PF03747.14 EWC48717.1 - 1.5e-66 225.1 0.0 2.4e-66 224.5 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase Ald_Xan_dh_C2 PF02738.18 EWC48718.1 - 2.8e-207 689.5 3.8 4.1e-207 689.0 3.8 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EWC48718.1 - 9.1e-45 152.4 0.0 1.8e-44 151.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EWC48718.1 - 1.9e-32 111.5 0.0 6.9e-32 109.7 0.0 2.1 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 EWC48718.1 - 3.1e-31 108.0 0.0 6.6e-31 106.9 0.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 EWC48718.1 - 2.7e-30 104.2 0.0 5.8e-30 103.1 0.0 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EWC48718.1 - 5.1e-09 36.0 0.5 1.5e-08 34.5 0.1 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 EWC48718.1 - 0.028 14.4 0.1 0.1 12.6 0.1 1.9 2 0 0 2 2 2 0 DUF218 domain CAP PF00188.26 EWC48719.1 - 5.4e-18 66.0 1.8 2e-17 64.2 1.8 1.8 1 1 0 1 1 1 1 Cysteine-rich secretory protein family ATP-synt_ab PF00006.25 EWC48720.1 - 1.8e-67 227.1 0.0 2.5e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EWC48720.1 - 2.8e-14 53.4 1.7 3.7e-14 53.0 0.7 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Trp_syntA PF00290.20 EWC48721.1 - 2.3e-92 308.5 0.2 2.3e-92 308.5 0.2 1.5 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.25 EWC48721.1 - 4.7e-48 164.1 1.0 8.8e-48 163.2 1.0 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme VapB_antitoxin PF09957.9 EWC48721.1 - 0.015 15.2 0.1 4.1 7.4 0.0 2.6 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB DFP PF04127.15 EWC48721.1 - 0.071 12.9 0.4 0.92 9.3 0.1 2.3 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein Gmad2 PF10648.9 EWC48721.1 - 0.15 12.4 0.0 0.43 10.8 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination Aminotran_3 PF00202.21 EWC48722.1 - 1.4e-90 303.8 0.0 2.1e-90 303.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III PapC_C PF13953.6 EWC48722.1 - 0.12 12.2 0.2 0.42 10.4 0.2 1.9 2 0 0 2 2 2 0 PapC C-terminal domain TIP49 PF06068.13 EWC48723.1 - 1.4e-166 554.0 0.3 1.8e-166 553.7 0.3 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EWC48723.1 - 3.8e-21 75.0 0.1 1e-20 73.6 0.1 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain RuvB_N PF05496.12 EWC48723.1 - 4.1e-12 46.1 0.3 9.2e-09 35.2 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 EWC48723.1 - 1.8e-11 44.6 0.3 6e-07 30.0 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC48723.1 - 2e-05 25.1 0.1 0.00029 21.3 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EWC48723.1 - 7.9e-05 23.0 0.1 0.1 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EWC48723.1 - 0.00076 19.8 0.7 0.0037 17.5 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EWC48723.1 - 0.00083 19.4 0.2 0.18 11.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EWC48723.1 - 0.0012 18.6 0.1 1.1 9.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_19 PF13245.6 EWC48723.1 - 0.0013 19.1 3.3 0.038 14.3 3.3 2.4 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EWC48723.1 - 0.0023 17.4 0.2 0.11 11.8 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EWC48723.1 - 0.0039 16.8 0.4 0.0091 15.6 0.1 1.7 2 0 0 2 2 2 1 AAA domain DnaB_C PF03796.15 EWC48723.1 - 0.0047 16.3 0.0 0.011 15.1 0.0 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 EWC48723.1 - 0.006 15.9 0.5 0.016 14.5 0.3 1.7 2 0 0 2 2 2 1 Zeta toxin Bac_DnaA PF00308.18 EWC48723.1 - 0.01 15.7 0.2 2 8.2 0.1 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_14 PF13173.6 EWC48723.1 - 0.013 15.6 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EWC48723.1 - 0.031 14.0 0.1 0.061 13.1 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EWC48723.1 - 0.036 13.4 0.6 0.17 11.2 0.1 2.1 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.6 EWC48723.1 - 0.052 14.1 0.1 0.25 11.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EWC48723.1 - 0.081 13.3 0.3 0.39 11.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EWC48723.1 - 0.1 12.1 0.2 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2075 PF09848.9 EWC48723.1 - 0.11 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) HMG_box PF00505.19 EWC48724.1 - 2.4e-13 50.3 2.8 4.8e-13 49.3 2.8 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EWC48724.1 - 0.033 14.8 0.7 0.067 13.8 0.7 1.4 1 0 0 1 1 1 0 HMG-box domain SelP_N PF04592.14 EWC48724.1 - 6.9 6.0 16.7 0.49 9.8 11.5 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region MgsA_C PF12002.8 EWC48725.1 - 7.4e-54 182.2 0.0 8.6e-53 178.7 0.0 2.2 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EWC48725.1 - 4.7e-23 81.3 0.0 1e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EWC48725.1 - 2.1e-07 31.4 0.0 3.7e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EWC48725.1 - 0.00042 20.7 0.0 0.0012 19.2 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EWC48725.1 - 0.001 19.1 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EWC48725.1 - 0.0024 17.6 0.0 0.0042 16.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EWC48725.1 - 0.0024 18.2 0.5 0.011 16.1 0.1 2.0 2 0 0 2 2 2 1 AAA domain zf-C2HC_2 PF13913.6 EWC48725.1 - 0.012 15.6 0.7 0.11 12.4 0.1 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type AAA_22 PF13401.6 EWC48725.1 - 0.017 15.4 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EWC48725.1 - 0.02 15.1 0.2 0.048 13.9 0.2 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EWC48725.1 - 0.031 13.5 0.0 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.22 EWC48725.1 - 0.043 13.0 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 EWC48725.1 - 0.055 13.2 0.1 0.087 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 EWC48725.1 - 0.064 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase Mg_chelatase PF01078.21 EWC48725.1 - 0.074 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI zf_C2H2_13 PF18508.1 EWC48725.1 - 0.078 12.6 0.3 0.18 11.4 0.3 1.6 1 0 0 1 1 1 0 Zinc finger domain ABC_tran PF00005.27 EWC48725.1 - 0.13 12.7 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 EWC48725.1 - 0.14 12.6 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EWC48725.1 - 0.19 11.6 0.0 2.2 8.2 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EWC48725.1 - 0.2 12.2 0.0 0.39 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EWC48725.1 - 0.21 11.3 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase S10_plectin PF03501.15 EWC48726.1 - 1.2e-42 143.8 0.4 1.5e-42 143.5 0.4 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Sde2_N_Ubi PF13019.6 EWC48727.1 - 3.2e-61 205.9 0.3 4.5e-61 205.4 0.3 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Nop25 PF09805.9 EWC48727.1 - 6.5 7.2 14.2 23 5.4 14.2 1.9 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) AMP-binding PF00501.28 EWC48728.1 - 2.5e-74 250.4 0.0 4.7e-74 249.5 0.0 1.4 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 EWC48728.1 - 3.2e-20 72.9 0.0 8.3e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ribosomal_L1 PF00687.21 EWC48729.1 - 3.8e-45 154.1 0.5 4.3e-45 154.0 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Aldo_ket_red PF00248.21 EWC48730.1 - 3.5e-41 141.3 0.0 4e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CK_II_beta PF01214.18 EWC48731.1 - 3.8e-71 238.7 0.0 5.9e-71 238.0 0.0 1.3 1 0 0 1 1 1 1 Casein kinase II regulatory subunit SLAC1 PF03595.17 EWC48732.1 - 3.8e-90 302.4 56.7 4.4e-90 302.2 56.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel bZIP_1 PF00170.21 EWC48733.1 - 0.00063 19.8 6.5 0.0014 18.6 6.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EWC48733.1 - 0.0032 17.5 4.9 0.0032 17.5 4.9 1.8 2 0 0 2 2 2 1 Basic region leucine zipper Mucin PF01456.17 EWC48734.1 - 0.0092 16.0 0.2 0.0092 16.0 0.2 3.8 3 0 0 3 3 3 2 Mucin-like glycoprotein Potex_coat PF06184.11 EWC48734.1 - 0.0098 15.5 0.1 0.021 14.4 0.1 1.5 1 0 0 1 1 1 1 Potexvirus coat protein Packaging_FI PF14000.6 EWC48734.1 - 0.059 13.8 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 DNA packaging protein FI Shisa PF13908.6 EWC48734.1 - 0.54 10.5 0.0 0.54 10.5 0.0 2.5 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator CIA30 PF08547.12 EWC48735.1 - 7.5e-31 107.3 0.0 1.3e-30 106.5 0.0 1.3 1 1 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Zip PF02535.22 EWC48737.1 - 1e-34 120.2 43.5 4.3e-15 55.8 6.5 4.4 3 1 1 4 4 4 4 ZIP Zinc transporter DUF2457 PF10446.9 EWC48737.1 - 2 7.5 9.0 3.3 6.7 9.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PRANC PF09372.10 EWC48738.1 - 0.19 12.1 0.3 1.5 9.2 0.0 2.0 1 1 1 2 2 2 0 PRANC domain DUF465 PF04325.13 EWC48739.1 - 0.00016 21.6 1.9 0.00016 21.6 1.9 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF465) PAM2 PF07145.15 EWC48739.1 - 0.024 14.3 0.1 0.024 14.3 0.1 3.3 3 0 0 3 3 3 0 Ataxin-2 C-terminal region CHASE9 PF17153.4 EWC48739.1 - 0.34 11.1 1.5 1.4 9.1 0.4 2.5 2 0 0 2 2 2 0 Periplasmic sensor domain, extracellular H-kinase_dim PF02895.14 EWC48739.1 - 1.9 8.9 4.9 1.5 9.2 1.1 3.0 2 0 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Pkinase PF00069.25 EWC48740.1 - 1.4e-20 73.8 0.0 1.1e-16 61.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48740.1 - 1.7e-14 53.7 0.0 1.8e-13 50.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EWC48740.1 - 0.041 13.2 0.0 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EWC48740.1 - 0.076 11.8 0.0 0.33 9.7 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase START PF01852.19 EWC48741.1 - 5.3e-06 26.0 0.0 7.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 START domain PipA PF07108.11 EWC48741.1 - 0.065 12.8 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 PipA protein YbaB_DNA_bd PF02575.16 EWC48741.1 - 0.12 12.6 1.0 0.24 11.7 1.0 1.4 1 0 0 1 1 1 0 YbaB/EbfC DNA-binding family Zn_clus PF00172.18 EWC48742.1 - 9.6e-11 41.6 15.1 1.5e-10 41.0 15.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EWC48742.1 - 0.0028 16.7 0.0 0.0072 15.4 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain CMD PF02627.20 EWC48743.1 - 0.0069 16.4 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Pyr_redox_3 PF13738.6 EWC48744.1 - 1.6e-17 63.7 0.0 3.4e-16 59.4 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EWC48744.1 - 1.4e-16 60.0 0.0 5.2e-13 48.3 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EWC48744.1 - 1.2e-10 41.1 0.0 1.8e-08 34.0 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EWC48744.1 - 7.8e-08 31.8 0.0 1.4e-05 24.4 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.20 EWC48744.1 - 2.4e-05 24.4 0.0 0.0015 18.6 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EWC48744.1 - 0.00015 21.2 0.0 0.24 10.8 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EWC48744.1 - 0.00021 21.7 0.0 0.12 12.9 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EWC48744.1 - 0.00028 21.1 0.0 0.82 9.9 0.0 2.5 2 0 0 2 2 2 2 TrkA-N domain NAD_binding_8 PF13450.6 EWC48744.1 - 0.00054 20.1 0.0 0.0062 16.7 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EWC48744.1 - 0.00064 18.9 0.1 0.13 11.3 0.0 2.9 3 0 0 3 3 3 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EWC48744.1 - 0.00085 18.7 0.0 1.5 7.9 0.0 2.8 3 0 0 3 3 3 2 FAD binding domain GIDA PF01134.22 EWC48744.1 - 0.0021 17.2 0.1 0.53 9.3 0.3 2.5 2 1 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EWC48744.1 - 0.0074 15.0 0.1 0.28 9.8 0.0 2.8 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 EWC48744.1 - 0.0085 15.7 0.0 7.1 6.1 0.0 3.4 4 0 0 4 4 4 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EWC48744.1 - 0.0099 16.3 0.0 0.13 12.7 0.0 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 EWC48744.1 - 0.024 13.7 0.1 0.34 9.9 0.0 2.4 3 0 0 3 3 3 0 FAD binding domain 3HCDH_N PF02737.18 EWC48744.1 - 0.031 14.2 0.0 0.46 10.3 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 EWC48744.1 - 0.031 13.6 0.0 0.06 12.7 0.0 1.4 1 0 0 1 1 1 0 ThiF family IlvN PF07991.12 EWC48744.1 - 0.052 13.1 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 EWC48744.1 - 0.15 11.3 0.0 6.9 5.9 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain RTA1 PF04479.13 EWC48745.1 - 9.5e-69 231.1 10.4 1.2e-68 230.8 10.4 1.1 1 0 0 1 1 1 1 RTA1 like protein FixQ PF05545.11 EWC48745.1 - 0.0063 16.5 3.1 3.8 7.6 0.0 3.8 3 0 0 3 3 3 2 Cbb3-type cytochrome oxidase component FixQ PalH PF08733.10 EWC48745.1 - 2.3 7.2 12.0 4.3 6.2 12.0 1.7 1 1 0 1 1 1 0 PalH/RIM21 DUF3425 PF11905.8 EWC48746.1 - 6e-17 61.8 0.0 1.4e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EWC48746.1 - 0.095 12.8 3.7 0.15 12.1 3.7 1.3 1 0 0 1 1 1 0 bZIP transcription factor Rhomboid PF01694.22 EWC48747.1 - 7e-23 81.3 18.3 1.5e-22 80.2 18.3 1.5 1 0 0 1 1 1 1 Rhomboid family FAP PF07174.11 EWC48747.1 - 0.39 10.1 12.0 0.61 9.5 12.0 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Apt1 PF10351.9 EWC48748.1 - 0.018 13.9 10.8 0.024 13.5 10.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 EWC48748.1 - 1.6 8.5 14.4 2.2 8.1 14.4 1.1 1 0 0 1 1 1 0 SPX domain DUF4614 PF15391.6 EWC48748.1 - 1.8 8.5 21.5 3.7 7.5 21.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.9 EWC48748.1 - 3 6.3 15.8 3.9 5.9 15.8 1.1 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 EWC48748.1 - 4.5 6.1 10.1 6.3 5.6 10.1 1.1 1 0 0 1 1 1 0 Mitoguardin Peroxin-3 PF04882.12 EWC48748.1 - 5.5 5.9 8.8 7.8 5.4 8.8 1.2 1 0 0 1 1 1 0 Peroxin-3 RAP1 PF07218.11 EWC48748.1 - 5.6 5.1 26.1 7.6 4.7 26.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Stevor PF17410.2 EWC48751.1 - 0.012 15.1 0.3 0.023 14.2 0.3 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame TrbC PF04956.13 EWC48751.1 - 0.032 14.5 0.4 0.032 14.5 0.4 1.9 2 0 0 2 2 2 0 TrbC/VIRB2 family MHYT PF03707.16 EWC48751.1 - 0.19 11.9 0.3 0.19 11.9 0.3 2.2 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat DoxX_2 PF13564.6 EWC48751.1 - 2.3 8.4 5.8 11 6.2 5.8 2.1 1 1 0 1 1 1 0 DoxX-like family DUF4233 PF14017.6 EWC48752.1 - 0.0074 16.6 0.9 0.012 15.9 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4233) DUF5125 PF17163.4 EWC48752.1 - 0.11 12.7 0.6 0.16 12.2 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5125) DEC-1_N PF04625.13 EWC48752.1 - 1.6 7.6 8.7 2 7.3 8.7 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region adh_short PF00106.25 EWC48753.1 - 3.9e-19 68.9 0.0 5.7e-11 42.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48753.1 - 4.5e-11 42.8 0.0 0.00015 21.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC48753.1 - 0.0018 18.2 0.0 0.0047 16.9 0.0 1.6 1 1 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EWC48753.1 - 0.055 13.2 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase SpecificRecomb PF10136.9 EWC48754.1 - 0.025 12.9 0.3 0.033 12.5 0.3 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF3336 PF11815.8 EWC48755.1 - 1.1e-37 128.8 0.0 2.2e-36 124.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EWC48755.1 - 1.1e-12 48.6 0.2 2.2e-12 47.6 0.1 1.6 1 1 0 1 1 1 1 Patatin-like phospholipase LapA_dom PF06305.11 EWC48755.1 - 0.69 9.8 3.1 2.2 8.1 0.3 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SURF4 PF02077.15 EWC48756.1 - 7.8e-100 333.9 6.7 8.9e-100 333.7 6.7 1.0 1 0 0 1 1 1 1 SURF4 family Tho2 PF11262.8 EWC48757.1 - 0.85 8.8 6.1 1.4 8.0 6.1 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 CHORD PF04968.12 EWC48758.1 - 5.6e-49 164.7 17.4 1.3e-24 86.6 5.4 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.16 EWC48758.1 - 3.4e-12 47.2 0.0 5.3e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 CS domain BTK PF00779.19 EWC48758.1 - 0.096 12.5 7.0 2.6 7.9 0.5 3.2 2 0 0 2 2 2 0 BTK motif DUF3712 PF12505.8 EWC48759.1 - 2.1e-22 79.7 0.4 2.1e-22 79.7 0.4 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3712) DUF4083 PF13314.6 EWC48759.1 - 0.014 15.3 3.2 0.027 14.4 3.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) DUF3671 PF12420.8 EWC48759.1 - 0.02 14.9 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF5383 PF17355.2 EWC48759.1 - 2.8 8.3 4.6 1.9 8.8 2.7 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5383) NAD_binding_8 PF13450.6 EWC48760.1 - 9.4e-10 38.6 0.0 2e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EWC48760.1 - 2.1e-09 37.1 0.0 4.7e-05 22.8 0.0 3.8 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EWC48760.1 - 2.6e-09 36.7 0.0 3e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC48760.1 - 7.2e-07 29.1 0.0 0.0018 17.9 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EWC48760.1 - 2.2e-06 27.8 0.5 0.047 13.7 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding FMO-like PF00743.19 EWC48760.1 - 4e-06 25.5 0.1 0.00015 20.3 0.1 2.8 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EWC48760.1 - 0.00035 19.8 0.1 1.6 7.8 0.0 3.6 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.20 EWC48760.1 - 0.00079 19.5 0.0 0.44 10.6 0.0 2.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 EWC48760.1 - 0.006 15.7 0.3 0.42 9.6 0.0 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A Amino_oxidase PF01593.24 EWC48760.1 - 0.007 15.7 0.0 0.34 10.2 0.0 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 EWC48760.1 - 0.0092 15.2 0.1 0.049 12.9 0.0 2.0 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EWC48760.1 - 0.015 14.4 0.1 0.044 12.9 0.1 1.8 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.19 EWC48760.1 - 0.04 13.2 0.1 0.085 12.1 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EWC48760.1 - 0.08 11.6 0.8 2.1 7.0 0.3 2.4 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EWC48760.1 - 0.17 12.5 0.0 7.8 7.1 0.1 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Zn_clus PF00172.18 EWC48761.1 - 1.2e-09 38.1 6.2 3.3e-09 36.7 6.2 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease PF00324.21 EWC48762.1 - 3.4e-109 365.6 40.7 4.1e-109 365.3 40.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EWC48762.1 - 2.6e-23 82.6 42.3 3.2e-23 82.2 42.3 1.0 1 0 0 1 1 1 1 Amino acid permease Catalase PF00199.19 EWC48763.1 - 3e-164 546.7 0.0 1.4e-163 544.4 0.0 1.8 1 1 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EWC48763.1 - 3e-16 59.4 0.1 1.1e-15 57.5 0.0 2.0 2 0 0 2 2 2 1 Catalase-related immune-responsive Fungal_trans PF04082.18 EWC48764.1 - 3.3e-11 42.7 0.1 5.7e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48764.1 - 1.4e-06 28.3 11.0 2.7e-06 27.4 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo_endo_phos PF03372.23 EWC48765.1 - 2.3e-13 50.2 0.3 1.5e-12 47.6 0.3 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EWC48765.1 - 0.0016 18.2 0.2 0.14 12.0 0.0 2.6 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase CRAL_TRIO PF00650.20 EWC48767.1 - 6.4e-24 84.5 0.0 9.4e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EWC48767.1 - 0.0002 21.4 0.0 0.00051 20.2 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF4752 PF15944.5 EWC48767.1 - 0.01 15.8 0.1 0.021 14.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) Peptidase_M22 PF00814.25 EWC48768.1 - 0.025 14.3 0.0 0.025 14.3 0.0 1.1 1 0 0 1 1 1 0 Glycoprotease family Pro-kuma_activ PF09286.11 EWC48769.1 - 6.4e-47 159.4 0.2 4.4e-45 153.5 0.0 2.5 3 0 0 3 3 3 2 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EWC48769.1 - 5.4e-05 22.6 0.2 9.8e-05 21.7 0.2 1.4 1 0 0 1 1 1 1 Subtilase family DUF3759 PF12585.8 EWC48770.1 - 0.0059 16.6 0.3 0.33 11.0 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3759) ZapB PF06005.12 EWC48770.1 - 0.011 16.1 1.1 0.047 14.1 0.1 2.1 2 0 0 2 2 2 0 Cell division protein ZapB TFIIF_alpha PF05793.12 EWC48770.1 - 0.19 10.3 17.4 0.29 9.7 17.4 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 EWC48770.1 - 2 6.9 13.5 2.5 6.6 13.5 1.1 1 0 0 1 1 1 0 Macoilin family FAM176 PF14851.6 EWC48770.1 - 6.9 6.3 10.9 7.2 6.3 0.7 2.3 2 0 0 2 2 2 0 FAM176 family GREB1 PF15782.5 EWC48770.1 - 7.2 3.6 11.0 8.2 3.4 11.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FMO-like PF00743.19 EWC48772.1 - 4.5e-16 58.4 1.0 1e-13 50.6 0.2 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EWC48772.1 - 1.5e-11 44.4 0.0 2.9e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EWC48772.1 - 4.7e-07 29.3 0.0 6.1e-05 22.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EWC48772.1 - 1.2e-06 28.6 0.4 6.2e-05 23.0 0.0 3.2 4 0 0 4 4 4 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EWC48772.1 - 8.9e-06 25.1 0.0 0.00075 18.7 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EWC48772.1 - 5.4e-05 22.6 0.3 0.00051 19.4 0.1 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EWC48772.1 - 5.5e-05 22.9 0.2 0.0022 17.6 0.2 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EWC48772.1 - 0.012 14.9 0.1 0.25 10.5 0.0 2.3 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EWC48772.1 - 0.055 12.6 0.0 0.096 11.7 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain CoA_binding PF02629.19 EWC48772.1 - 0.11 13.2 0.1 14 6.4 0.0 2.4 2 0 0 2 2 2 0 CoA binding domain AlaDh_PNT_C PF01262.21 EWC48772.1 - 0.12 11.7 0.0 0.67 9.2 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EWC48772.1 - 0.21 10.2 0.0 0.33 9.6 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein SMYLE_N PF18615.1 EWC48773.1 - 0.056 13.0 5.5 0.071 12.7 5.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Smg8_Smg9 PF10220.9 EWC48773.1 - 0.42 8.9 5.4 0.51 8.6 5.4 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Hid1 PF12722.7 EWC48773.1 - 1.4 7.0 5.0 1.4 7.0 5.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 EWC48773.1 - 1.5 8.6 8.4 2.3 8.0 8.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3827 PF12877.7 EWC48773.1 - 1.6 7.0 11.3 1.8 6.9 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Neur_chan_memb PF02932.16 EWC48773.1 - 2.1 8.4 4.3 2.7 8.0 4.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 EWC48773.1 - 2.5 7.2 6.7 3.1 6.9 6.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 EWC48773.1 - 3.1 6.0 7.5 3.5 5.9 7.5 1.1 1 0 0 1 1 1 0 Menin CCDC106 PF15794.5 EWC48773.1 - 3.2 7.4 15.5 5.2 6.7 15.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SOBP PF15279.6 EWC48773.1 - 3.8 8.0 11.2 4.7 7.7 11.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 EWC48773.1 - 5.6 5.6 9.7 6.9 5.3 9.7 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EWC48773.1 - 5.7 5.5 7.7 5.6 5.5 7.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC45 PF02724.14 EWC48773.1 - 8.4 4.5 12.0 11 4.2 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Sugar_tr PF00083.24 EWC48774.1 - 3.2e-89 299.9 22.9 3.7e-89 299.7 22.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC48774.1 - 4.2e-29 101.6 22.8 4.8e-29 101.4 15.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EWC48774.1 - 3.2e-05 23.0 10.5 0.00096 18.1 7.2 2.4 2 1 0 2 2 2 2 MFS_1 like family ATP-synt_Z PF16594.5 EWC48774.1 - 0.027 13.9 0.0 0.081 12.4 0.0 1.8 1 0 0 1 1 1 0 Putative AtpZ or ATP-synthase-associated Band_7 PF01145.25 EWC48775.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 SPFH domain / Band 7 family APOC4 PF15119.6 EWC48775.1 - 0.13 12.5 0.1 0.48 10.7 0.1 1.9 2 0 0 2 2 2 0 Apolipoprotein C4 PRELI PF04707.14 EWC48776.1 - 5.9e-32 110.7 0.4 8.3e-31 106.9 0.3 2.0 2 0 0 2 2 2 1 PRELI-like family Thiamine_BP PF01910.17 EWC48776.1 - 0.013 15.4 0.1 0.026 14.4 0.1 1.5 1 0 0 1 1 1 0 Thiamine-binding protein HMG_CoA_synt_C PF08540.10 EWC48776.1 - 0.074 12.7 0.0 0.094 12.3 0.0 1.1 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal EMP24_GP25L PF01105.24 EWC48777.1 - 1.8e-42 145.3 0.0 2.5e-42 144.9 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Sigma70_ner PF04546.13 EWC48777.1 - 0.066 13.1 4.5 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region TFIIF_alpha PF05793.12 EWC48777.1 - 0.077 11.6 0.4 0.1 11.2 0.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CENP-B_dimeris PF09026.10 EWC48777.1 - 0.15 12.4 6.4 0.32 11.4 6.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 EWC48777.1 - 1.5 9.1 6.9 1.6 9.0 3.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 EWC48777.1 - 7 7.1 10.4 0.37 11.2 4.4 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal tRNA-synt_1b PF00579.25 EWC48778.1 - 1e-19 71.0 0.0 2.1e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) CBM_1 PF00734.18 EWC48779.1 - 6.7e-15 54.7 11.4 1.7e-14 53.5 11.4 1.7 1 0 0 1 1 1 1 Fungal cellulose binding domain Glyco_hydro_16 PF00722.21 EWC48779.1 - 6.8e-10 38.7 6.5 6.8e-10 38.7 6.5 1.8 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 SH3_1 PF00018.28 EWC48780.1 - 9.8e-15 53.9 0.0 1.6e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EWC48780.1 - 1.8e-12 46.9 0.0 3.3e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EWC48780.1 - 1.1e-06 28.2 0.0 1.8e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain GFA PF04828.14 EWC48781.1 - 7.4e-09 35.8 0.2 0.00086 19.6 0.0 2.4 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme Cwf_Cwc_15 PF04889.12 EWC48781.1 - 0.39 10.4 3.4 0.96 9.1 3.4 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CH PF00307.31 EWC48782.1 - 2.8e-16 59.6 0.0 4.8e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Pox_A_type_inc PF04508.12 EWC48782.1 - 0.0062 16.3 0.4 0.0062 16.3 0.4 3.5 4 0 0 4 4 4 1 Viral A-type inclusion protein repeat CAMSAP_CH PF11971.8 EWC48782.1 - 0.014 15.2 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 CAMSAP CH domain CDC24 PF06395.11 EWC48782.1 - 0.061 13.6 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 CDC24 Calponin 2OG-FeII_Oxy_3 PF13640.6 EWC48786.1 - 4e-09 37.2 0.0 7.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Trypan_PARP PF05887.11 EWC48787.1 - 0.0002 21.3 0.1 0.0002 21.3 0.1 1.7 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Spt20 PF12090.8 EWC48787.1 - 0.0011 18.6 1.6 0.0014 18.3 1.6 1.2 1 0 0 1 1 1 1 Spt20 family SPX PF03105.19 EWC48787.1 - 0.014 15.3 1.2 0.02 14.9 1.2 1.1 1 0 0 1 1 1 0 SPX domain Activator_LAG-3 PF11498.8 EWC48787.1 - 0.055 12.4 17.1 0.09 11.7 17.1 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 EWC48787.1 - 1.1 9.1 15.7 2.1 8.3 15.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF390 PF04094.14 EWC48787.1 - 9.8 4.3 7.7 13 3.9 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) WH2 PF02205.20 EWC48788.1 - 6.8e-11 41.6 1.2 6.8e-11 41.6 1.2 2.1 2 0 0 2 2 2 1 WH2 motif CAP59_mtransfer PF11735.8 EWC48789.1 - 2.6e-86 289.2 0.0 3.2e-86 289.0 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DUF3237 PF11578.8 EWC48792.1 - 3.2e-42 143.9 0.0 3.6e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) F-box-like PF12937.7 EWC48793.1 - 0.001 18.9 0.6 0.0037 17.1 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EWC48793.1 - 0.016 15.1 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 F-box domain LSM PF01423.22 EWC48794.1 - 1.3e-17 63.2 0.0 1.7e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain EMP24_GP25L PF01105.24 EWC48795.1 - 1e-50 172.2 0.2 1.2e-50 172.0 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Mob1_phocein PF03637.17 EWC48796.1 - 1.4e-57 194.4 0.1 1.9e-57 193.9 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family Leo1 PF04004.13 EWC48797.1 - 5.9e-28 97.8 0.0 5.9e-28 97.8 0.0 2.5 2 0 0 2 2 2 1 Leo1-like protein TraV PF09676.10 EWC48798.1 - 1.8 9.6 12.2 0.13 13.3 5.9 2.1 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) PAT1 PF09770.9 EWC48798.1 - 3 6.0 10.4 4.2 5.5 10.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SET PF00856.28 EWC48799.1 - 2.5e-07 31.2 0.2 4.2e-07 30.5 0.2 1.3 1 1 0 1 1 1 1 SET domain DOCK_N PF16172.5 EWC48801.1 - 1.8e-105 353.0 0.0 2.7e-105 352.4 0.0 1.3 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 EWC48801.1 - 4.9e-29 101.5 0.0 9.3e-29 100.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 EWC48801.1 - 8.4e-29 100.6 0.0 4e-28 98.4 0.0 1.9 1 1 0 1 1 1 1 Dock homology region 2 DUF4075 PF13294.6 EWC48803.1 - 0.16 12.2 0.0 12 6.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4075) PIEZO PF15917.5 EWC48803.1 - 0.16 11.4 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Piezo LPP PF04728.13 EWC48804.1 - 3.7 8.0 4.7 3.5 8.1 2.8 2.0 1 1 1 2 2 2 0 Lipoprotein leucine-zipper GGN PF15685.5 EWC48805.1 - 0.021 13.9 0.7 0.024 13.7 0.7 1.1 1 0 0 1 1 1 0 Gametogenetin TraT PF05818.12 EWC48805.1 - 0.033 13.9 1.3 0.043 13.5 1.3 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF2280 PF10045.9 EWC48805.1 - 0.066 13.5 0.0 0.74 10.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2280) Frataxin_Cyay PF01491.16 EWC48806.1 - 3e-35 120.6 0.0 3.5e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain WD40 PF00400.32 EWC48807.1 - 6.6e-05 23.6 2.2 0.049 14.5 0.0 4.1 3 1 1 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48807.1 - 0.00076 19.7 0.6 0.32 11.3 0.1 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ctf8 PF09696.10 EWC48809.1 - 7.1e-36 123.7 0.1 2.1e-35 122.1 0.1 1.7 1 1 0 1 1 1 1 Ctf8 SlyX PF04102.12 EWC48810.1 - 2.7 8.7 4.9 2.8 8.6 2.0 2.6 2 0 0 2 2 2 0 SlyX PHP PF02811.19 EWC48811.1 - 1.7e-12 47.9 0.0 2.7e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 PHP domain tRNA-synt_1 PF00133.22 EWC48812.1 - 2.1e-35 122.0 0.0 2.6e-26 92.1 0.0 3.3 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EWC48812.1 - 7.2e-15 54.6 0.0 8.5e-09 34.6 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EWC48812.1 - 3e-11 43.5 0.0 1.1e-10 41.7 0.0 2.0 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EWC48812.1 - 2.4e-06 27.1 0.0 4.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Methyltransf_23 PF13489.6 EWC48813.1 - 4.2e-23 82.0 0.0 6.4e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC48813.1 - 1.7e-12 47.9 0.0 1.1e-11 45.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EWC48813.1 - 4.7e-10 40.0 0.0 9.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EWC48813.1 - 2.3e-08 34.0 0.0 4.6e-07 29.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC48813.1 - 8.3e-06 26.5 0.0 4.5e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC48813.1 - 0.00065 19.1 0.0 0.0032 16.8 0.0 2.1 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EWC48813.1 - 0.0016 17.8 0.0 0.0026 17.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 EWC48813.1 - 0.004 16.7 0.0 0.0065 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EWC48813.1 - 0.0076 15.7 0.6 0.022 14.2 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.20 EWC48813.1 - 0.021 14.1 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EWC48813.1 - 0.035 13.8 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PrmA PF06325.13 EWC48813.1 - 0.13 11.6 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Lsm_C PF14894.6 EWC48813.1 - 0.16 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Lsm C-terminal DUF2470 PF10615.9 EWC48814.1 - 3e-16 59.8 0.2 5.3e-16 59.0 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) F-box-like PF12937.7 EWC48815.1 - 0.00012 21.9 1.0 0.00012 21.9 1.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EWC48815.1 - 0.0084 16.0 0.2 0.026 14.4 0.1 1.9 2 0 0 2 2 2 1 F-box domain Melibiase_2 PF16499.5 EWC48816.1 - 3.7e-52 177.3 3.8 6.8e-52 176.4 3.8 1.5 1 1 0 1 1 1 1 Alpha galactosidase A CBM_1 PF00734.18 EWC48816.1 - 3.2e-10 39.8 9.8 3.2e-10 39.8 9.8 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain Melibiase_C PF17801.1 EWC48816.1 - 6.8e-08 32.5 0.7 6.8e-08 32.5 0.7 2.4 3 0 0 3 3 3 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EWC48816.1 - 8.7e-05 21.6 0.1 0.0004 19.4 0.0 2.0 2 0 0 2 2 2 1 Melibiase Glyco_hydro_10 PF00331.20 EWC48817.1 - 2.1e-101 339.2 0.0 2.5e-101 339.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.18 EWC48817.1 - 1.8e-13 50.2 10.7 1.8e-13 50.2 10.7 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain Glyco_hydro_42 PF02449.15 EWC48817.1 - 0.028 13.7 0.1 0.71 9.1 0.1 2.1 1 1 1 2 2 2 0 Beta-galactosidase F-box-like PF12937.7 EWC48818.1 - 9.6e-07 28.6 2.3 0.0018 18.2 0.3 2.7 1 1 1 2 2 2 2 F-box-like F-box PF00646.33 EWC48818.1 - 2e-05 24.4 0.9 0.053 13.4 0.1 2.7 2 0 0 2 2 2 2 F-box domain F-box-like PF12937.7 EWC48819.1 - 3.9e-08 33.1 0.2 8.5e-08 32.0 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC48819.1 - 5.4e-05 23.0 0.1 0.0001 22.1 0.1 1.4 1 0 0 1 1 1 1 F-box domain Sushi PF00084.20 EWC48819.1 - 0.12 13.0 0.0 0.33 11.6 0.0 1.7 1 0 0 1 1 1 0 Sushi repeat (SCR repeat) NYN PF01936.18 EWC48820.1 - 2.7e-06 27.9 0.0 1.6e-05 25.4 0.0 1.9 1 1 1 2 2 2 1 NYN domain DnaJ PF00226.31 EWC48821.1 - 4.9e-25 87.4 0.5 1.4e-24 86.0 0.5 1.8 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 EWC48821.1 - 7.9e-11 42.0 3.3 7.9e-11 42.0 3.3 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EWC48821.1 - 1.6e-08 34.7 3.0 1.6e-08 34.7 3.0 1.9 2 0 0 2 2 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EWC48821.1 - 3.1e-08 33.9 10.3 0.00058 20.2 0.7 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EWC48821.1 - 1.8e-05 25.2 2.3 0.22 12.4 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EWC48821.1 - 0.00047 20.5 6.0 0.2 12.2 0.9 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EWC48821.1 - 0.044 13.8 0.8 0.044 13.8 0.8 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2778 PF10908.8 EWC48821.1 - 0.065 13.5 0.4 0.78 10.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2778) Churchill PF06573.11 EWC48821.1 - 0.15 12.4 1.7 1.5 9.2 0.6 2.4 2 0 0 2 2 2 0 Churchill protein CpXC PF14353.6 EWC48821.1 - 0.19 11.8 5.3 1 9.4 0.0 3.6 4 0 0 4 4 4 0 CpXC protein Zn-ribbon_8 PF09723.10 EWC48821.1 - 0.19 11.8 3.1 2.2 8.5 0.3 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 EWC48821.1 - 0.36 11.3 3.6 0.65 10.5 0.1 2.7 3 0 0 3 3 2 0 Zinc-finger double domain zf-C2H2_3rep PF18868.1 EWC48821.1 - 1.4 9.6 6.1 20 5.8 0.0 3.3 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats F-box-like PF12937.7 EWC48822.1 - 0.00088 19.1 1.2 0.0015 18.4 1.2 1.3 1 0 0 1 1 1 1 F-box-like Fasciclin PF02469.22 EWC48823.1 - 9.7e-44 148.7 0.0 3.7e-23 82.2 0.0 2.1 2 0 0 2 2 2 2 Fasciclin domain Sugar_tr PF00083.24 EWC48824.1 - 8.1e-110 367.8 16.9 9.3e-110 367.6 16.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC48824.1 - 4.2e-21 75.3 25.4 7.3e-21 74.5 25.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EWC48825.1 - 1.2e-10 40.9 0.4 5.7e-10 38.7 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48825.1 - 5.4e-09 36.0 9.3 1.1e-08 35.1 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CATSPERG PF15064.6 EWC48825.1 - 0.00077 17.4 0.0 0.0011 16.9 0.0 1.1 1 0 0 1 1 1 1 Cation channel sperm-associated protein subunit gamma MFS_1 PF07690.16 EWC48826.1 - 3.2e-38 131.6 52.5 2.4e-37 128.7 53.2 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF4407 PF14362.6 EWC48826.1 - 0.0044 16.4 8.2 1.3 8.3 0.2 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF4407) TPIP1 PF15338.6 EWC48826.1 - 0.035 14.2 0.3 0.09 12.8 0.3 1.7 1 0 0 1 1 1 0 p53-regulated apoptosis-inducing protein 1 Phage_holin_5_1 PF06946.11 EWC48826.1 - 9.9 6.6 8.9 3.3 8.2 0.8 3.1 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 Dioxygenase_C PF00775.21 EWC48827.1 - 1.4e-08 34.4 0.1 2.3e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 Dioxygenase GLEYA PF10528.9 EWC48828.1 - 1.3e-22 80.0 0.2 2.6e-22 79.1 0.2 1.5 1 0 0 1 1 1 1 GLEYA domain PA14 PF07691.12 EWC48828.1 - 5e-07 29.6 0.0 6.9e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 PA14 domain Ank_2 PF12796.7 EWC48830.1 - 1.1e-33 115.6 1.8 2.2e-08 34.5 0.0 5.9 3 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EWC48830.1 - 1.2e-30 105.4 2.0 2e-06 28.2 0.1 7.7 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EWC48830.1 - 1.4e-22 77.3 1.0 0.00017 21.7 0.0 8.6 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EWC48830.1 - 8.5e-20 70.6 1.9 4.2e-05 23.8 0.0 5.7 6 0 0 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EWC48830.1 - 1.5e-14 53.7 9.0 0.082 13.4 0.0 8.0 8 0 0 8 8 8 4 Ankyrin repeat SPRY PF00622.28 EWC48830.1 - 8.7e-13 48.4 0.1 1.8e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 SPRY domain NACHT PF05729.12 EWC48830.1 - 7.5e-07 29.2 0.1 5.6e-06 26.4 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EWC48830.1 - 1.3e-05 25.6 0.0 4.9e-05 23.8 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 EWC48830.1 - 0.0062 15.8 0.1 0.8 8.9 0.0 3.0 2 1 0 2 2 2 1 KAP family P-loop domain CBF PF03914.17 EWC48830.1 - 0.094 12.7 0.1 11 6.0 0.0 2.9 3 0 0 3 3 3 0 CBF/Mak21 family Apolipoprotein PF01442.18 EWC48830.1 - 0.13 12.2 7.3 0.077 12.9 0.9 2.7 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain DUF713 PF05218.14 EWC48830.1 - 0.23 11.2 2.5 0.17 11.6 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF713) Otopetrin PF03189.13 EWC48831.1 - 0.011 14.6 2.8 0.015 14.2 2.8 1.1 1 0 0 1 1 1 0 Otopetrin F-box-like PF12937.7 EWC48832.1 - 0.045 13.7 0.0 0.069 13.1 0.0 1.4 1 1 0 1 1 1 0 F-box-like Sugar_tr PF00083.24 EWC48834.1 - 1.3e-126 423.2 23.4 1.5e-126 423.0 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EWC48834.1 - 1.7e-27 96.3 29.8 1.1e-16 60.7 12.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-BED PF02892.15 EWC48835.1 - 4.4 7.4 5.5 26 5.0 0.8 2.8 2 0 0 2 2 2 0 BED zinc finger ArAE_2_N PF10337.9 EWC48838.1 - 5.2e-77 259.9 4.8 1.6e-75 255.0 0.1 2.7 3 0 0 3 3 3 2 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 EWC48838.1 - 9.7e-39 133.5 0.0 1.5e-35 123.1 0.0 2.4 2 0 0 2 2 2 2 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 EWC48838.1 - 5.5e-09 36.2 17.5 5.5e-09 36.2 17.5 3.4 3 0 0 3 3 3 1 Fusaric acid resistance protein-like Glyco_hydro_108 PF05838.12 EWC48838.1 - 0.096 13.2 0.0 0.37 11.3 0.0 2.0 1 0 0 1 1 1 0 Glycosyl hydrolase 108 DUF2866 PF11065.8 EWC48839.1 - 0.095 12.7 0.4 0.18 11.8 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2866) MARVEL PF01284.23 EWC48841.1 - 1.6e-24 86.6 14.1 1.9e-24 86.3 14.1 1.0 1 0 0 1 1 1 1 Membrane-associating domain PalH PF08733.10 EWC48841.1 - 0.026 13.6 2.2 0.029 13.4 2.2 1.1 1 0 0 1 1 1 0 PalH/RIM21 NDUFA12 PF05071.16 EWC48842.1 - 6.4e-09 36.5 0.1 1.3e-08 35.6 0.1 1.5 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 ALIX_LYPXL_bnd PF13949.6 EWC48842.1 - 0.024 14.0 0.1 0.043 13.1 0.1 1.3 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Mto2_bdg PF12808.7 EWC48842.1 - 0.042 14.1 3.4 0.063 13.6 1.5 2.3 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Pkinase PF00069.25 EWC48843.1 - 3e-74 249.7 0.0 4.2e-74 249.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48843.1 - 3.2e-38 131.5 0.0 4.8e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EWC48843.1 - 6.3e-24 84.7 1.1 1.6e-09 38.2 0.0 4.0 3 1 0 3 3 3 3 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 EWC48843.1 - 2.9e-08 33.7 0.0 6.1e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EWC48843.1 - 8.7e-08 31.8 0.0 1.7e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EWC48843.1 - 0.013 15.1 0.4 0.037 13.6 0.0 1.8 2 0 0 2 2 2 0 RIO1 family YukC PF10140.9 EWC48843.1 - 0.014 14.2 0.1 0.023 13.6 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Haspin_kinase PF12330.8 EWC48843.1 - 0.016 14.2 0.1 0.027 13.4 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain SUIM_assoc PF16619.5 EWC48843.1 - 0.028 14.5 1.8 0.13 12.4 1.8 2.1 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 EWC48843.1 - 0.25 11.3 4.1 0.14 12.1 0.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit APH PF01636.23 EWC48843.1 - 1.2 9.1 5.2 0.61 10.0 0.2 2.7 3 0 0 3 3 3 0 Phosphotransferase enzyme family zf-CCHC PF00098.23 EWC48845.1 - 4.2e-32 108.8 73.2 3.9e-07 29.8 1.6 9.2 9 0 0 9 9 9 7 Zinc knuckle zf-CCHC_6 PF15288.6 EWC48845.1 - 3.4e-06 26.8 57.3 6.1e-05 22.8 0.2 7.8 7 1 1 8 8 8 6 Zinc knuckle zf-CCHC_3 PF13917.6 EWC48845.1 - 3.6e-06 26.8 47.9 0.11 12.4 0.2 7.3 2 2 4 6 6 6 5 Zinc knuckle zf-CCHC_4 PF14392.6 EWC48845.1 - 8.5e-06 25.4 42.7 0.43 10.4 1.6 7.8 8 0 0 8 8 8 6 Zinc knuckle zf-CCHC_2 PF13696.6 EWC48845.1 - 5.9e-05 22.8 59.7 0.018 14.9 1.3 8.2 8 0 0 8 8 8 6 Zinc knuckle zf-C2H2_10 PF16588.5 EWC48845.1 - 0.00045 19.9 0.5 0.00045 19.9 0.5 7.1 7 0 0 7 7 7 1 C2H2 zinc-finger PLDc PF00614.22 EWC48847.1 - 1.1e-17 63.4 0.3 1.2e-08 34.7 0.2 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PX PF00787.24 EWC48847.1 - 3e-11 43.3 0.5 7.3e-10 38.8 0.0 2.9 2 1 0 2 2 2 1 PX domain PLDc_2 PF13091.6 EWC48847.1 - 5.4e-11 42.5 0.0 1.7e-06 28.0 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PH PF00169.29 EWC48847.1 - 0.0018 18.7 0.0 0.0042 17.6 0.0 1.7 1 0 0 1 1 1 1 PH domain CBM_19 PF03427.13 EWC48847.1 - 1.9 8.6 5.0 5.5 7.0 5.0 1.8 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) Oxysterol_BP PF01237.18 EWC48848.1 - 5.9e-116 387.4 0.2 1.1e-115 386.5 0.2 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EWC48848.1 - 6.4e-32 109.7 0.0 1.3e-31 108.7 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EWC48848.1 - 0.005 17.3 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 PH domain Podoplanin PF05808.11 EWC48849.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Podoplanin Alpha_GJ PF03229.13 EWC48849.1 - 0.013 16.0 1.5 0.036 14.6 0.0 2.3 2 0 0 2 2 2 0 Alphavirus glycoprotein J Actin PF00022.19 EWC48850.1 - 7.6e-124 413.4 0.0 3.6e-123 411.2 0.0 1.8 1 1 0 1 1 1 1 Actin zf-CCHC PF00098.23 EWC48851.1 - 0.0014 18.6 4.4 0.0082 16.2 1.8 2.6 2 0 0 2 2 2 1 Zinc knuckle eIF3g PF12353.8 EWC48851.1 - 0.003 18.0 9.5 0.13 12.6 3.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor 3 subunit G DUF3602 PF12223.8 EWC48852.1 - 6.6e-18 65.1 5.4 8.3e-15 55.2 0.5 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) Peptidase_S28 PF05577.12 EWC48853.1 - 2.7e-50 171.5 0.0 1.9e-49 168.6 0.0 2.1 1 1 0 1 1 1 1 Serine carboxypeptidase S28 AP2 PF00847.20 EWC48853.1 - 0.061 13.6 1.8 6.2 7.1 0.6 2.6 2 0 0 2 2 2 0 AP2 domain Aldedh PF00171.22 EWC48854.1 - 1.9e-78 264.0 0.0 2.3e-78 263.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fungal_lectin PF07938.12 EWC48855.1 - 6.1e-10 39.0 0.2 1.1e-09 38.2 0.2 1.4 1 0 0 1 1 1 1 Fungal fucose-specific lectin ECR1_N PF14382.6 EWC48856.1 - 6.7e-15 54.6 0.0 1.3e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EWC48856.1 - 8.4e-13 48.5 0.1 1.6e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 KH domain Amidohydro_2 PF04909.14 EWC48857.1 - 1e-05 25.5 0.1 2.3e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 EWC48857.1 - 0.0015 17.9 2.8 0.015 14.7 0.1 2.9 2 1 0 2 2 2 1 Amidohydrolase family eIF-5_eIF-2B PF01873.17 EWC48858.1 - 5.4e-39 132.7 0.0 1.1e-38 131.6 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Sec1 PF00995.23 EWC48861.1 - 4.6e-134 448.8 0.1 5.2e-134 448.6 0.1 1.0 1 0 0 1 1 1 1 Sec1 family DUF1043 PF06295.12 EWC48861.1 - 0.22 11.5 6.5 0.36 10.8 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) adh_short PF00106.25 EWC48862.1 - 1.6e-36 125.6 0.1 2.3e-36 125.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48862.1 - 2.4e-28 99.3 0.2 3.2e-28 98.9 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC48862.1 - 1.8e-08 34.5 0.5 7.6e-08 32.5 0.5 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EWC48862.1 - 0.00012 21.7 0.0 0.00018 21.0 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family UPF0146 PF03686.13 EWC48862.1 - 0.035 14.0 0.0 0.69 9.8 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0146) RmlD_sub_bind PF04321.17 EWC48862.1 - 0.059 12.5 0.0 0.092 11.8 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Cyclase PF04199.13 EWC48862.1 - 0.073 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative cyclase CbiA PF01656.23 EWC48862.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain zf_CCCH_4 PF18345.1 EWC48863.1 - 0.00018 21.5 2.7 0.00031 20.7 2.7 1.4 1 0 0 1 1 1 1 Zinc finger domain WD40 PF00400.32 EWC48866.1 - 1.4e-45 152.3 25.9 3.3e-09 37.2 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48866.1 - 1.3e-08 35.0 0.6 0.1 12.9 0.0 4.4 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EWC48866.1 - 2.5e-05 23.1 5.5 0.14 10.7 0.1 4.4 2 2 2 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EWC48866.1 - 0.0045 16.0 0.1 8.6 5.2 0.0 4.0 2 2 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EWC48866.1 - 0.0092 15.3 0.0 0.68 9.2 0.0 2.6 2 1 0 3 3 3 1 WD40-like domain PD40 PF07676.12 EWC48866.1 - 0.015 15.2 0.3 23 5.1 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat FHA PF00498.26 EWC48867.1 - 2.9e-12 46.7 0.0 5.9e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EWC48867.1 - 0.052 13.9 0.0 0.2 12.0 0.0 1.9 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Plus-3 PF03126.18 EWC48868.1 - 4.5e-23 81.8 0.0 1.1e-22 80.6 0.0 1.7 1 0 0 1 1 1 1 Plus-3 domain Pkinase PF00069.25 EWC48869.1 - 8.3e-68 228.6 0.0 1.4e-67 227.8 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EWC48869.1 - 1.9e-31 109.3 0.0 3.1e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EWC48869.1 - 0.012 14.5 0.0 0.051 12.5 0.0 1.7 1 1 1 2 2 2 0 Haspin like kinase domain APH PF01636.23 EWC48869.1 - 0.039 13.9 0.1 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EWC48869.1 - 0.043 13.2 0.1 0.095 12.0 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PLDc_2 PF13091.6 EWC48870.1 - 3.3e-18 65.9 0.0 5.1e-12 45.8 0.0 3.1 2 2 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EWC48870.1 - 0.0034 17.5 0.8 1.2 9.4 0.0 3.4 4 0 0 4 4 4 2 Phospholipase D Active site motif Regulator_TrmB PF11495.8 EWC48870.1 - 0.016 14.4 0.0 0.037 13.2 0.0 1.5 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB Sas10 PF09368.10 EWC48871.1 - 1.1e-29 102.8 5.4 1.1e-29 102.8 5.4 2.8 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EWC48871.1 - 0.0018 18.8 4.1 0.0023 18.5 0.0 3.2 3 1 1 4 4 4 1 Sas10/Utp3/C1D family MLVIN_C PF18697.1 EWC48872.1 - 0.033 14.3 0.1 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DUF4884 PF16225.5 EWC48872.1 - 0.13 12.4 0.2 0.2 11.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4884) MFS_1 PF07690.16 EWC48873.1 - 9.5e-34 116.9 24.7 9.5e-34 116.9 24.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EWC48873.1 - 0.0024 17.6 4.0 0.0052 16.5 4.0 1.6 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 F-box-like PF12937.7 EWC48876.1 - 0.0065 16.3 0.2 0.015 15.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC48876.1 - 0.04 13.8 0.1 0.069 13.1 0.1 1.4 1 0 0 1 1 1 0 F-box domain RasGAP PF00616.19 EWC48877.1 - 4.8e-31 108.1 0.0 9.1e-21 74.5 0.0 2.3 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EWC48877.1 - 0.02 15.2 0.0 0.045 14.1 0.0 1.6 1 0 0 1 1 1 0 C2 domain Lactamase_B PF00753.27 EWC48878.1 - 0.00034 20.7 0.2 0.00063 19.8 0.2 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EWC48878.1 - 0.0017 17.9 0.0 0.0037 16.8 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TPR_1 PF00515.28 EWC48880.1 - 3.3e-41 137.5 17.7 0.00037 20.2 0.0 11.5 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48880.1 - 6.3e-41 135.2 16.0 0.0008 19.3 0.1 11.7 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_11 PF13414.6 EWC48880.1 - 1.3e-23 82.4 26.5 1.4e-05 24.6 0.1 8.8 7 2 1 8 8 8 6 TPR repeat TPR_8 PF13181.6 EWC48880.1 - 1.8e-23 80.7 18.7 0.0028 17.7 0.0 10.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48880.1 - 1.3e-21 76.9 3.2 0.0004 21.0 0.2 7.0 5 2 1 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EWC48880.1 - 3.3e-20 71.0 2.3 0.05 14.0 0.0 9.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_9 PF13371.6 EWC48880.1 - 1.3e-15 57.3 2.1 7.3e-05 22.8 0.0 5.2 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48880.1 - 3e-14 53.3 16.5 7.9e-05 23.1 1.0 7.3 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EWC48880.1 - 6.8e-14 51.4 9.7 0.028 15.2 0.2 8.7 5 4 5 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48880.1 - 2.3e-13 50.2 22.9 8e-05 22.9 2.9 9.0 5 3 4 9 9 9 5 Tetratricopeptide repeat TPR_7 PF13176.6 EWC48880.1 - 1.9e-10 40.0 20.1 0.011 15.8 0.2 9.1 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_15 PF13429.6 EWC48880.1 - 1.3e-09 37.7 2.3 0.0027 17.0 0.4 4.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EWC48880.1 - 7.8e-08 32.1 1.0 2.3e-06 27.2 0.2 3.1 2 1 0 3 3 3 1 MalT-like TPR region ANAPC3 PF12895.7 EWC48880.1 - 1.4e-06 28.5 10.8 0.015 15.5 0.2 5.2 3 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TAF1_subA PF14929.6 EWC48880.1 - 0.00018 21.0 1.0 0.0018 17.7 0.2 2.3 2 1 0 2 2 2 1 TAF RNA Polymerase I subunit A TPR_10 PF13374.6 EWC48880.1 - 0.00031 20.5 19.4 0.044 13.7 0.2 7.7 10 0 0 10 10 7 1 Tetratricopeptide repeat TAtT PF16811.5 EWC48880.1 - 0.0014 18.0 0.2 4.3 6.6 0.0 3.6 2 1 1 3 3 3 2 TRAP transporter T-component DUF3808 PF10300.9 EWC48880.1 - 0.0016 17.3 0.4 1.3 7.7 0.0 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF3808) NTP_transferase PF00483.23 EWC48880.1 - 0.0068 16.0 0.1 0.02 14.5 0.1 1.7 1 0 0 1 1 1 1 Nucleotidyl transferase TPR_6 PF13174.6 EWC48880.1 - 0.02 15.5 21.8 5.6 7.8 0.4 8.3 10 0 0 10 10 8 0 Tetratricopeptide repeat SPO22 PF08631.10 EWC48880.1 - 0.041 13.4 5.4 6.8 6.1 0.0 3.9 5 0 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 EWC48880.1 - 0.041 13.9 19.4 15 5.7 0.3 7.3 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain Wzy_C_2 PF11846.8 EWC48880.1 - 0.061 13.2 1.1 0.81 9.6 0.1 2.8 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal SHNi-TPR PF10516.9 EWC48880.1 - 0.49 9.9 15.8 3 7.4 0.0 5.6 7 0 0 7 7 6 0 SHNi-TPR TPR_4 PF07721.14 EWC48880.1 - 1.4 9.7 4.5 27 5.8 0.0 5.1 7 0 0 7 7 3 0 Tetratricopeptide repeat Sel1 PF08238.12 EWC48880.1 - 3.7 8.4 4.7 12 6.7 0.0 3.7 5 0 0 5 5 2 0 Sel1 repeat BTAD PF03704.17 EWC48880.1 - 4 7.9 6.5 29 5.1 0.1 3.8 4 1 0 4 4 3 0 Bacterial transcriptional activator domain TPR_3 PF07720.12 EWC48880.1 - 4.7 7.3 14.8 23 5.1 0.3 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat PCRF PF03462.18 EWC48881.1 - 3.5e-46 157.5 0.1 8.2e-46 156.3 0.0 1.7 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EWC48881.1 - 1.3e-36 125.0 2.4 3.3e-36 123.7 2.4 1.7 1 0 0 1 1 1 1 RF-1 domain FliT PF05400.13 EWC48881.1 - 0.12 13.2 0.2 0.12 13.2 0.2 2.5 2 1 1 3 3 3 0 Flagellar protein FliT CorA PF01544.18 EWC48881.1 - 0.14 11.4 0.4 0.25 10.6 0.4 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein adh_short PF00106.25 EWC48882.1 - 5.3e-33 114.1 0.0 8.4e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EWC48882.1 - 3.6e-23 82.3 0.0 6.6e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EWC48882.1 - 8.1e-07 29.1 0.3 4.9e-06 26.6 0.3 2.0 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EWC48882.1 - 8.4e-07 28.4 0.4 1.7e-06 27.5 0.4 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 EWC48882.1 - 0.0042 17.0 0.2 0.007 16.3 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Meleagrin PF08189.11 EWC48882.1 - 0.077 12.7 1.9 0.69 9.7 1.9 2.2 1 1 0 1 1 1 0 Meleagrin/Cygnin family NAD_binding_10 PF13460.6 EWC48882.1 - 0.14 12.0 2.1 0.43 10.4 0.8 2.4 2 1 0 2 2 2 0 NAD(P)H-binding Shikimate_DH PF01488.20 EWC48882.1 - 0.19 11.8 1.9 0.36 10.9 0.9 1.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase APH PF01636.23 EWC48883.1 - 2.1e-12 47.5 0.0 5.5e-12 46.1 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EWC48883.1 - 0.00041 20.0 0.0 0.00057 19.5 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF5386 PF17360.2 EWC48885.1 - 0.79 9.6 7.0 2.6 7.9 0.2 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5386) Amnionless PF14828.6 EWC48886.1 - 0.013 14.4 0.3 0.015 14.1 0.3 1.1 1 0 0 1 1 1 0 Amnionless ABC2_membrane_3 PF12698.7 EWC48886.1 - 0.025 13.7 0.1 0.033 13.3 0.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Macoilin PF09726.9 EWC48886.1 - 0.062 11.9 3.5 0.069 11.7 3.5 1.1 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 EWC48886.1 - 0.49 9.9 1.5 0.59 9.6 1.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 EWC48886.1 - 1.2 7.8 3.5 0.4 9.4 0.7 1.6 2 0 0 2 2 2 0 Presenilin RAP1 PF07218.11 EWC48886.1 - 3.9 5.6 14.8 5.3 5.2 14.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Nucleo_P87 PF07267.11 EWC48886.1 - 4.3 6.1 4.6 4.4 6.0 4.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SPX PF03105.19 EWC48886.1 - 4.7 7.0 10.2 5.3 6.9 10.2 1.2 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 EWC48886.1 - 4.7 5.8 11.4 7.2 5.2 11.4 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Podoplanin PF05808.11 EWC48886.1 - 5.4 7.1 16.6 32 4.6 16.6 2.0 1 1 0 1 1 1 0 Podoplanin Dynamin_N PF00350.23 EWC48887.1 - 1.3e-28 100.2 0.3 3.3e-28 98.9 0.1 1.8 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 EWC48887.1 - 4.2e-25 88.6 0.0 1.1e-24 87.2 0.0 1.7 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 EWC48887.1 - 0.00063 19.8 0.2 0.0081 16.2 0.0 2.9 3 1 0 3 3 3 1 50S ribosome-binding GTPase Gln-synt_C PF00120.24 EWC48888.1 - 3.4e-20 72.3 0.0 3.8e-16 59.0 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EWC48888.1 - 5e-12 45.4 0.0 1.1e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain SLS PF14611.6 EWC48888.1 - 0.04 13.7 0.0 0.074 12.9 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator G_glu_transpept PF01019.21 EWC48889.1 - 1.1e-140 469.9 0.0 1.2e-140 469.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Dehydratase_MU PF02288.15 EWC48889.1 - 0.023 14.6 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 Dehydratase medium subunit SRAP PF02586.14 EWC48890.1 - 3.3e-74 249.1 0.0 4.5e-74 248.7 0.0 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) TPR_12 PF13424.6 EWC48891.1 - 4.9e-10 39.6 1.7 0.41 11.0 0.0 5.3 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48891.1 - 1.2e-08 34.4 12.2 0.035 14.2 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EWC48891.1 - 9.8e-06 25.4 12.3 0.58 10.5 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EWC48891.1 - 2.8e-05 24.5 2.6 1.5 9.6 0.1 4.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EWC48891.1 - 5.2e-05 22.9 10.9 0.74 9.7 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EWC48891.1 - 0.0004 20.2 2.4 1.9 8.7 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 EWC48891.1 - 0.0015 18.0 2.4 1.2 8.5 0.1 2.8 3 0 0 3 3 3 2 Soluble NSF attachment protein, SNAP HHH_8 PF14716.6 EWC48891.1 - 0.0066 16.8 3.7 2.3 8.6 0.1 3.2 3 0 0 3 3 3 2 Helix-hairpin-helix domain TPR_10 PF13374.6 EWC48891.1 - 0.016 15.1 2.6 13 5.8 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.17 EWC48891.1 - 0.096 13.1 2.5 0.56 10.6 0.1 2.8 2 1 1 3 3 3 0 Bacterial transcriptional activator domain DUF948 PF06103.11 EWC48892.1 - 0.13 12.6 0.1 20 5.5 0.1 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) zf-U1 PF06220.12 EWC48893.1 - 4.6e-06 26.3 0.3 6.8e-06 25.8 0.3 1.2 1 0 0 1 1 1 1 U1 zinc finger DUF5388 PF17363.2 EWC48893.1 - 0.23 11.7 0.2 0.77 10.0 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5388) PALP PF00291.25 EWC48894.1 - 1.8e-41 142.5 0.7 5.6e-36 124.5 0.5 2.1 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme 2OG-FeII_Oxy_2 PF13532.6 EWC48895.1 - 8.6e-24 84.8 0.0 2.1e-14 54.2 0.0 2.5 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 EWC48895.1 - 2.7e-18 66.8 0.7 3.9e-16 59.7 0.1 2.9 2 1 0 2 2 2 1 Isochorismatase family ZF-HD_dimer PF04770.12 EWC48896.1 - 0.0021 18.3 4.2 0.0044 17.3 4.2 1.5 1 0 0 1 1 1 1 ZF-HD protein dimerisation region MRNIP PF15749.5 EWC48896.1 - 0.023 15.4 1.4 0.041 14.6 1.4 1.6 1 1 0 1 1 1 0 MRN-interacting protein DUF3431 PF11913.8 EWC48898.1 - 7.9e-74 248.1 0.0 9.1e-74 247.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Asp PF00026.23 EWC48899.1 - 2e-05 24.2 0.1 4.1e-05 23.2 0.1 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease F-box_4 PF15966.5 EWC48900.1 - 0.0012 18.7 0.1 0.003 17.4 0.1 1.7 1 0 0 1 1 1 1 F-box LRR_4 PF12799.7 EWC48900.1 - 1.2 9.7 7.7 2.1 8.9 0.1 4.1 2 2 1 3 3 3 0 Leucine Rich repeats (2 copies) Cytochrom_B561 PF03188.16 EWC48905.1 - 0.00011 22.3 7.1 0.00026 21.1 7.1 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 EWC48905.1 - 0.00019 21.2 5.3 0.0004 20.1 4.1 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF2427) Protocadherin PF08374.11 EWC48905.1 - 0.022 14.7 0.1 0.022 14.7 0.1 1.5 2 0 0 2 2 2 0 Protocadherin SNF2_N PF00176.23 EWC48907.1 - 3.7e-74 249.5 0.2 7.1e-74 248.6 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EWC48907.1 - 1.4e-39 134.7 1.6 1.4e-39 134.7 1.6 2.6 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 EWC48907.1 - 5.4e-34 117.3 3.6 5.4e-34 117.3 3.6 3.7 4 0 0 4 4 3 1 HAND Helicase_C PF00271.31 EWC48907.1 - 1.3e-18 67.4 0.1 4e-18 65.8 0.0 2.0 2 0 0 2 2 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EWC48907.1 - 5.9e-12 45.9 0.0 3.1e-11 43.6 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EWC48907.1 - 2.7e-05 23.5 0.1 0.0002 20.6 0.0 2.4 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EWC48907.1 - 0.00032 20.5 0.0 0.00095 18.9 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DEAD PF00270.29 EWC48907.1 - 0.0033 17.2 0.0 0.014 15.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 EWC48907.1 - 0.008 15.8 0.0 0.025 14.2 0.0 1.8 1 0 0 1 1 1 1 DEAD_2 AAA_14 PF13173.6 EWC48907.1 - 0.044 13.8 0.0 0.25 11.4 0.0 2.4 1 0 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.31 EWC48907.1 - 0.085 13.1 0.0 13 6.1 0.0 3.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain AAA_22 PF13401.6 EWC48907.1 - 0.099 12.9 0.4 0.85 9.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF4588 PF15251.6 EWC48908.1 - 1e-07 32.0 0.0 2.7e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) Fungus-induced PF10917.8 EWC48908.1 - 0.25 11.7 0.2 0.25 11.7 0.2 2.4 3 0 0 3 3 3 0 Fungus-induced protein DUF3712 PF12505.8 EWC48910.1 - 8.1e-24 84.3 2.5 8.1e-24 84.3 2.5 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3712) DUF1565 PF07602.11 EWC48910.1 - 0.017 14.5 1.9 0.09 12.1 0.2 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1565) zf-C2H2 PF00096.26 EWC48911.1 - 6.7e-05 23.1 11.9 0.0039 17.6 1.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type ZapB PF06005.12 EWC48911.1 - 0.008 16.6 1.2 0.016 15.6 1.2 1.4 1 0 0 1 1 1 1 Cell division protein ZapB HALZ PF02183.18 EWC48911.1 - 0.023 14.9 0.3 0.056 13.7 0.3 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper TLE_N PF03920.15 EWC48911.1 - 0.04 14.0 0.5 0.082 13.0 0.5 1.4 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain zf-C2H2_4 PF13894.6 EWC48911.1 - 0.079 13.8 9.7 1.9 9.6 0.6 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger RNB PF00773.19 EWC48912.1 - 1.7e-84 283.9 0.0 3.1e-84 283.1 0.0 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EWC48912.1 - 2.5e-26 91.5 0.0 7.3e-26 90.0 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 EWC48912.1 - 3.2e-26 91.5 0.0 9.3e-26 90.0 0.0 1.8 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 EWC48912.1 - 1.9e-06 27.9 0.0 0.012 15.8 0.0 2.9 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EWC48912.1 - 0.0044 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EWC48912.1 - 0.044 13.7 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 S1 domain NPR3 PF03666.13 EWC48912.1 - 0.1 11.4 0.8 0.31 9.8 0.8 1.8 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ferritin_2 PF13668.6 EWC48913.1 - 2.8e-38 131.2 0.8 4.2e-38 130.6 0.8 1.3 1 0 0 1 1 1 1 Ferritin-like domain IU_nuc_hydro PF01156.19 EWC48914.1 - 4.4e-58 197.3 0.0 6.4e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Pyocin_S PF06958.12 EWC48915.1 - 0.00019 22.0 2.8 0.00034 21.2 2.8 1.5 1 0 0 1 1 1 1 S-type Pyocin zf-C2H2 PF00096.26 EWC48915.1 - 0.06 13.8 4.7 0.42 11.2 0.5 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type AAA_12 PF13087.6 EWC48917.1 - 1.8e-37 128.9 0.0 3.9e-37 127.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EWC48917.1 - 6.2e-23 81.9 0.0 1.6e-22 80.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EWC48917.1 - 8.9e-10 39.1 0.0 4.4e-09 36.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EWC48917.1 - 9.6e-07 28.7 0.0 0.00021 21.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EWC48917.1 - 1.8e-06 27.5 0.0 0.00091 18.6 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) zf-C2H2 PF00096.26 EWC48918.1 - 2.4e-05 24.5 11.8 0.028 14.9 1.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EWC48918.1 - 0.00073 19.8 5.7 0.0017 18.6 5.7 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EWC48918.1 - 0.0029 17.9 4.8 0.0029 17.9 4.8 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EWC48918.1 - 0.0036 18.0 7.6 0.27 12.2 1.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-U1 PF06220.12 EWC48918.1 - 0.24 11.2 3.4 0.27 11.0 1.9 1.9 2 0 0 2 2 2 0 U1 zinc finger zf-C2H2_2 PF12756.7 EWC48918.1 - 1.2 9.5 9.5 0.3 11.4 3.3 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EWC48919.1 - 8.7e-05 22.8 7.6 0.018 15.5 0.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EWC48919.1 - 0.00011 22.7 4.0 0.32 12.0 0.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EWC48919.1 - 0.00026 21.3 1.5 0.027 14.9 0.3 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EWC48919.1 - 0.00054 20.2 2.3 0.2 12.0 0.1 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding HNH_5 PF14279.6 EWC48919.1 - 0.0073 16.2 0.2 0.84 9.5 0.0 3.1 3 0 0 3 3 3 1 HNH endonuclease zf-C2H2_2 PF12756.7 EWC48919.1 - 0.061 13.7 3.3 0.25 11.7 0.5 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) HNH PF01844.23 EWC48919.1 - 0.41 10.9 0.1 0.41 10.9 0.1 2.5 3 0 0 3 3 3 0 HNH endonuclease zf-BED PF02892.15 EWC48919.1 - 3 8.0 8.3 1.8 8.7 2.5 2.4 1 1 1 2 2 2 0 BED zinc finger MutS_V PF00488.21 EWC48920.1 - 1.2e-43 149.4 0.4 2.5e-43 148.3 0.4 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EWC48920.1 - 9.3e-25 88.0 0.0 2.3e-24 86.7 0.0 1.7 2 0 0 2 2 2 1 MutS domain III AAA_22 PF13401.6 EWC48920.1 - 0.059 13.6 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain RPW8 PF05659.11 EWC48920.1 - 0.063 13.0 0.0 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_30 PF13604.6 EWC48920.1 - 0.082 12.6 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain Ino80_Iec3 PF14612.6 EWC48921.1 - 3.2e-33 116.4 3.4 2.9e-22 80.5 1.0 2.3 2 0 0 2 2 2 2 IEC3 subunit of the Ino80 complex, chromatin re-modelling RRM_1 PF00076.22 EWC48922.1 - 4.4e-19 68.1 2.6 5.3e-11 42.2 0.1 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RR_TM4-6 PF06459.12 EWC48922.1 - 0.63 9.8 4.1 1.1 9.1 1.8 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 YL1 PF05764.13 EWC48922.1 - 1.3 9.1 17.0 0.023 14.8 7.5 2.3 2 0 0 2 2 2 0 YL1 nuclear protein CENP-B_dimeris PF09026.10 EWC48922.1 - 5 7.6 9.7 11 6.5 9.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GLEYA PF10528.9 EWC48926.1 - 1.7e-20 73.2 0.1 2.6e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 GLEYA domain PA14 PF07691.12 EWC48926.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 PA14 domain LRR_4 PF12799.7 EWC48927.1 - 0.016 15.6 1.0 12 6.5 0.0 3.7 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) Methyltransf_31 PF13847.6 EWC48928.1 - 3e-06 27.1 0.0 4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EWC48928.1 - 3.4e-06 27.7 0.0 6.1e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EWC48928.1 - 0.00011 22.8 0.0 0.0002 22.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EWC48928.1 - 0.00042 19.7 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EWC48928.1 - 0.0038 17.9 0.0 0.0076 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EWC48928.1 - 0.0079 16.2 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF3433 PF11915.8 EWC48929.1 - 1.7e-37 127.7 15.6 1.5e-20 73.4 4.2 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) MMgT PF10270.9 EWC48930.1 - 4e-31 107.3 0.0 5.2e-31 106.9 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter EF1_GNE PF00736.19 EWC48931.1 - 2.1e-32 111.1 0.9 2.1e-32 111.1 0.9 1.5 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EWC48931.1 - 8.8e-15 54.9 8.2 8.8e-15 54.9 8.2 2.4 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region CPDase PF07823.11 EWC48932.1 - 2.5e-20 73.1 0.0 3.4e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 EWC48932.1 - 7.5e-06 25.9 0.1 4.8e-05 23.3 0.1 1.9 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily F-box-like PF12937.7 EWC48935.1 - 0.0065 16.3 0.2 0.02 14.8 0.2 1.9 1 1 0 1 1 1 1 F-box-like TLP1_add_C PF18313.1 EWC48936.1 - 1.4e-28 98.7 0.0 1.8e-27 95.1 0.0 2.4 2 0 0 2 2 2 1 Thiolase-like protein type 1 additional C-terminal domain F-box PF00646.33 EWC48937.1 - 3.4e-08 33.2 1.1 6.8e-08 32.2 1.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EWC48937.1 - 1.2e-06 28.2 1.3 3.2e-06 26.9 1.3 1.7 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 EWC48938.1 - 1.5e-05 24.8 0.3 2.8e-05 23.9 0.3 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EWC48938.1 - 0.0072 16.2 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box PF00646.33 EWC48940.1 - 0.0003 20.6 0.1 0.00061 19.6 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EWC48940.1 - 0.005 16.7 0.9 0.0089 15.9 0.9 1.4 1 0 0 1 1 1 1 F-box-like DUF3500 PF12006.8 EWC48940.1 - 0.2 11.1 0.0 21 4.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3500) CFEM PF05730.11 EWC48941.1 - 1.7e-10 40.8 5.9 3.1e-10 40.0 5.9 1.4 1 0 0 1 1 1 1 CFEM domain DUF3275 PF11679.8 EWC48942.1 - 0.12 12.3 0.2 0.2 11.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) DUF3597 PF12200.8 EWC48942.1 - 0.14 12.7 1.3 0.27 11.7 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) TPR_1 PF00515.28 EWC48944.1 - 1.7e-15 56.1 1.5 0.00039 20.1 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EWC48944.1 - 4.2e-13 48.3 5.2 0.0035 17.4 0.2 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EWC48944.1 - 6.1e-09 35.4 0.6 1.4e-06 27.9 0.1 3.9 2 1 2 4 4 4 2 TPR repeat TPR_17 PF13431.6 EWC48944.1 - 8.9e-06 25.7 0.2 0.023 15.1 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EWC48944.1 - 6.4e-05 22.9 1.0 0.64 10.4 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EWC48944.1 - 7.4e-05 23.2 1.3 7.4e-05 23.2 1.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EWC48944.1 - 0.00011 22.3 0.8 0.00011 22.3 0.8 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EWC48944.1 - 0.00097 19.4 5.4 0.016 15.5 1.5 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EWC48944.1 - 0.0028 18.3 1.2 0.0028 18.3 1.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EWC48944.1 - 0.0055 17.4 6.1 4.6 8.3 0.3 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EWC48944.1 - 0.11 12.4 1.9 0.9 9.5 0.7 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ADH_N PF08240.12 EWC48945.1 - 2.7e-06 27.2 0.1 1.5e-05 24.9 0.1 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EWC48945.1 - 6.4e-05 22.9 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Aldo_ket_red PF00248.21 EWC48946.1 - 5.5e-48 163.7 0.0 4e-46 157.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Ribosomal_S5 PF00333.20 EWC48946.1 - 0.2 11.6 0.0 0.47 10.5 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein S5, N-terminal domain Cellulase PF00150.18 EWC48947.1 - 1.2e-16 61.1 0.1 1e-12 48.1 0.0 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 EWC48947.1 - 2.5e-11 43.9 0.7 1.6e-10 41.4 0.7 2.2 1 1 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain DUF1115 PF06544.12 EWC48948.1 - 4.8e-13 49.5 0.0 7.8e-13 48.8 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) Acylphosphatase PF00708.18 EWC48948.1 - 0.0018 18.7 0.0 0.0033 17.8 0.0 1.4 1 0 0 1 1 1 1 Acylphosphatase Lactamase_B_2 PF12706.7 EWC48949.1 - 0.001 18.6 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EWC48949.1 - 0.0013 18.6 0.0 0.0029 17.5 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Ribosomal_L6e PF01159.19 EWC48953.1 - 6.2e-35 120.1 0.0 8.9e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e Rad10 PF03834.14 EWC48954.1 - 3.6e-46 155.9 0.0 5.5e-46 155.3 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EWC48954.1 - 8.4e-06 26.3 0.0 1.9e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 EWC48954.1 - 0.00016 21.3 0.0 0.00035 20.3 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Asp PF00026.23 EWC48955.1 - 5.2e-67 226.5 0.5 6.8e-67 226.1 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EWC48955.1 - 7.5e-15 55.6 3.2 1.7e-13 51.2 0.9 3.5 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EWC48955.1 - 0.00014 22.4 0.2 0.42 11.3 0.2 3.3 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EWC48955.1 - 0.00017 21.4 0.0 0.00034 20.4 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Abhydrolase_1 PF00561.20 EWC48956.1 - 4.6e-12 46.1 0.3 8.7e-11 41.9 0.0 2.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EWC48956.1 - 8.6e-09 36.3 2.4 5e-07 30.5 2.4 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EWC48956.1 - 4.3e-06 26.2 0.0 0.0013 18.0 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EWC48956.1 - 0.0064 16.1 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EWC48956.1 - 0.029 13.8 0.0 0.3 10.5 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF551 PF04448.12 EWC48956.1 - 0.082 13.9 0.1 0.65 11.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF551) Fungal_trans PF04082.18 EWC48957.1 - 2e-22 79.5 0.1 3.6e-20 72.1 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48957.1 - 1.2e-06 28.5 7.5 2.1e-06 27.7 7.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S30 PF04758.14 EWC48958.1 - 4.4e-30 103.7 7.7 4.8e-30 103.5 7.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Cyt-b5 PF00173.28 EWC48959.1 - 1.2e-08 34.9 0.1 1.4e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HLH PF00010.26 EWC48960.1 - 6.4e-16 58.1 1.3 1.4e-15 56.9 1.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4200 PF13863.6 EWC48960.1 - 0.051 14.0 4.1 0.082 13.3 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) BOP1NT PF08145.12 EWC48961.1 - 1.8e-106 355.8 3.9 2.4e-106 355.4 3.9 1.1 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EWC48961.1 - 1.7e-28 98.3 5.9 5.2e-09 36.6 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EWC48961.1 - 2.2e-07 31.1 0.2 0.01 16.1 0.1 5.2 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nop53 PF07767.11 EWC48961.1 - 0.013 14.9 0.5 0.013 14.9 0.5 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Frtz PF11768.8 EWC48961.1 - 0.073 11.4 0.0 1.8 6.8 0.0 2.0 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Fungal_trans PF04082.18 EWC48962.1 - 8e-19 67.7 0.9 1.2e-18 67.1 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48962.1 - 6.7e-09 35.7 10.6 1.1e-08 35.1 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran_CTD PF16326.5 EWC48962.1 - 0.0043 17.3 0.2 0.12 12.6 0.0 3.0 2 0 0 2 2 2 1 ABC transporter C-terminal domain DiS_P_DiS PF06750.13 EWC48962.1 - 0.87 9.7 3.0 2 8.6 3.0 1.5 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain Fungal_trans PF04082.18 EWC48963.1 - 6.5e-21 74.5 0.1 1.2e-20 73.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EWC48963.1 - 1.3e-08 34.9 11.9 2.4e-08 34.0 11.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VCX_VCY PF15231.6 EWC48964.1 - 0.11 13.1 1.7 0.16 12.6 0.7 1.6 2 0 0 2 2 2 0 Variable charge X/Y family PhoD PF09423.10 EWC48965.1 - 2.2e-96 322.9 3.7 2.7e-96 322.6 3.7 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EWC48965.1 - 2.2e-29 101.8 1.3 5.2e-29 100.6 0.4 2.1 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 EWC48965.1 - 0.0015 19.1 0.3 0.0044 17.6 0.3 1.8 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Torus PF16131.5 EWC48966.1 - 1.6e-08 35.2 2.8 0.0026 18.4 0.8 2.5 2 0 0 2 2 2 2 Torus domain zf-CCCH PF00642.24 EWC48966.1 - 9.3e-06 25.4 10.7 0.011 15.6 4.5 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EWC48966.1 - 5.2e-05 23.2 20.7 0.015 15.4 6.2 2.4 2 0 0 2 2 2 2 Zinc finger domain AWS PF17907.1 EWC48966.1 - 0.038 14.0 1.0 8.1 6.6 0.1 2.4 2 0 0 2 2 2 0 AWS domain Neogenin_C PF06583.12 EWC48966.1 - 0.42 10.4 9.5 0.65 9.8 9.5 1.2 1 0 0 1 1 1 0 Neogenin C-terminus Acyl-CoA_dh_1 PF00441.24 EWC48967.1 - 4.8e-31 108.0 0.2 6.6e-31 107.5 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EWC48967.1 - 1.4e-18 66.9 0.1 2.7e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EWC48967.1 - 5e-10 40.0 0.2 1.9e-09 38.2 0.0 2.1 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EWC48967.1 - 6.2e-06 26.5 0.1 9.6e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain FLgD_tudor PF13861.6 EWC48967.1 - 0.052 13.8 0.0 0.15 12.3 0.0 1.9 1 1 0 1 1 1 0 FlgD Tudor-like domain SNF5 PF04855.12 EWC48968.1 - 1.1e-39 136.6 0.1 6.2e-21 75.3 0.0 2.1 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 GATA PF00320.27 EWC48968.1 - 0.00016 21.2 1.2 0.00041 19.9 0.3 2.2 2 0 0 2 2 2 1 GATA zinc finger PilZ_2 PF16823.5 EWC48968.1 - 0.34 11.1 1.4 16 5.7 0.2 2.4 2 0 0 2 2 2 0 Atypical PilZ domain, cyclic di-GMP receptor UL42 PF17638.2 EWC48968.1 - 0.97 9.4 6.8 9.4 6.2 0.4 2.6 2 0 0 2 2 2 0 HCMV UL42 RRM_1 PF00076.22 EWC48969.1 - 7.2e-62 205.1 0.0 5.2e-19 67.8 0.0 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EWC48969.1 - 0.015 15.1 0.0 6 6.8 0.0 2.6 2 0 0 2 2 2 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EWC48969.1 - 0.073 13.2 0.0 0.92 9.6 0.0 2.9 3 0 0 3 3 3 0 Limkain b1 Nup35_RRM PF05172.13 EWC48969.1 - 0.077 13.0 0.0 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif NosL PF05573.12 EWC48969.1 - 0.15 12.4 0.5 0.76 10.1 0.0 2.3 3 0 0 3 3 3 0 NosL VPS9 PF02204.18 EWC48970.1 - 6.8e-28 96.9 0.0 1.1e-27 96.2 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EWC48970.1 - 1.5e-13 50.8 0.0 3.7e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EWC48970.1 - 6.5e-08 32.1 0.0 1.4e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 CUE domain MARVEL PF01284.23 EWC48971.1 - 9.7e-05 22.4 26.4 0.00013 22.0 26.4 1.1 1 0 0 1 1 1 1 Membrane-associating domain AAA PF00004.29 EWC48972.1 - 1e-15 58.3 0.0 3.3e-15 56.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EWC48972.1 - 0.0035 17.6 0.7 0.22 11.8 0.1 2.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EWC48972.1 - 0.0056 17.1 0.3 0.023 15.1 0.3 2.2 1 1 0 1 1 1 1 AAA ATPase domain Zot PF05707.12 EWC48972.1 - 0.05 13.2 0.4 0.64 9.6 0.0 2.6 3 0 0 3 3 3 0 Zonular occludens toxin (Zot) AAA_5 PF07728.14 EWC48972.1 - 0.056 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EWC48972.1 - 0.087 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EWC48972.1 - 0.11 11.8 0.5 0.29 10.5 0.2 1.8 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 EWC48972.1 - 0.16 11.9 0.0 0.5 10.3 0.0 1.9 1 0 0 1 1 1 0 NACHT domain CFEM PF05730.11 EWC48973.1 - 1.4e-06 28.3 4.7 2.4e-06 27.5 4.7 1.3 1 0 0 1 1 1 1 CFEM domain DUF5327 PF17261.2 EWC48973.1 - 0.039 14.7 0.0 0.31 11.8 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5327) CDC27 PF09507.10 EWC48973.1 - 0.21 10.9 3.3 0.43 9.9 3.3 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AAA_2 PF07724.14 EWC48974.1 - 7.2e-49 166.2 0.0 1.7e-47 161.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EWC48974.1 - 2.7e-33 114.0 4.3 3.7e-33 113.6 0.3 2.5 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EWC48974.1 - 4.2e-23 81.2 0.5 1.4e-22 79.5 0.5 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EWC48974.1 - 4.5e-22 78.9 0.0 5.4e-12 46.3 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EWC48974.1 - 7e-15 55.2 0.1 1.1e-09 38.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EWC48974.1 - 3e-11 44.0 5.2 1.9e-05 25.1 0.1 4.3 3 2 0 3 3 2 2 AAA ATPase domain ATPase_2 PF01637.18 EWC48974.1 - 5e-10 39.7 0.1 0.0096 15.9 0.1 3.9 3 1 0 3 3 3 3 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EWC48974.1 - 3.9e-09 36.9 0.1 0.0079 16.5 0.0 3.7 2 2 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EWC48974.1 - 4.1e-07 29.9 0.3 0.00055 19.7 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_7 PF12775.7 EWC48974.1 - 5.2e-07 29.3 0.0 0.013 15.0 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 EWC48974.1 - 6.5e-07 29.4 0.0 0.02 14.9 0.0 3.0 3 1 0 3 3 3 2 AAA domain TniB PF05621.11 EWC48974.1 - 1.3e-06 28.0 0.0 0.01 15.2 0.0 3.5 2 1 0 2 2 2 1 Bacterial TniB protein AAA_23 PF13476.6 EWC48974.1 - 7.7e-06 26.5 5.3 1.2 9.6 2.1 3.6 3 1 0 3 3 3 2 AAA domain NACHT PF05729.12 EWC48974.1 - 1.2e-05 25.2 0.0 0.055 13.4 0.0 2.7 2 0 0 2 2 2 2 NACHT domain IstB_IS21 PF01695.17 EWC48974.1 - 5.6e-05 22.9 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_30 PF13604.6 EWC48974.1 - 8.4e-05 22.4 0.2 0.17 11.5 0.0 3.7 3 0 0 3 3 3 1 AAA domain ResIII PF04851.15 EWC48974.1 - 0.0002 21.4 0.0 2.3 8.2 0.0 3.7 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 EWC48974.1 - 0.0003 20.7 0.0 0.67 9.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase Roc PF08477.13 EWC48974.1 - 0.00042 20.5 0.0 0.6 10.3 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EWC48974.1 - 0.00046 20.7 0.0 0.28 11.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EWC48974.1 - 0.00054 20.3 0.0 1.7 9.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 EWC48974.1 - 0.0008 19.2 0.0 0.58 9.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EWC48974.1 - 0.00084 19.3 0.0 1.9 8.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 EWC48974.1 - 0.001 18.7 0.0 1.8 8.1 0.0 3.2 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 EWC48974.1 - 0.0012 18.0 0.2 0.032 13.3 0.2 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 EWC48974.1 - 0.0014 19.2 0.2 2 8.9 0.0 3.1 3 0 0 3 3 3 1 ABC transporter AAA_28 PF13521.6 EWC48974.1 - 0.0019 18.4 0.0 3.6 7.8 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EWC48974.1 - 0.002 18.3 0.0 1.6 8.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EWC48974.1 - 0.0023 17.2 0.2 2.2 7.4 0.0 3.4 2 1 1 3 3 3 1 NB-ARC domain Mg_chelatase PF01078.21 EWC48974.1 - 0.0026 17.2 0.0 0.73 9.2 0.0 2.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EWC48974.1 - 0.0041 16.7 0.0 0.97 9.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain ATP_bind_1 PF03029.17 EWC48974.1 - 0.009 15.8 0.0 3.4 7.4 0.0 2.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 EWC48974.1 - 0.0093 15.7 0.0 4.6 7.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_19 PF13245.6 EWC48974.1 - 0.017 15.4 0.2 1.3 9.3 0.0 3.2 3 1 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 EWC48974.1 - 0.033 13.1 0.0 3.1 6.6 0.0 2.6 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 EWC48974.1 - 0.039 13.8 0.0 9.5 6.1 0.0 2.8 2 0 0 2 2 2 0 NTPase AAA_21 PF13304.6 EWC48974.1 - 0.045 13.5 0.4 1.1 9.0 0.0 2.9 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF4407 PF14362.6 EWC48974.1 - 0.059 12.7 4.8 0.1 12.0 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) cobW PF02492.19 EWC48974.1 - 0.059 12.9 0.0 7.5 6.1 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain OmpH PF03938.14 EWC48974.1 - 3.1 8.1 7.4 2.8 8.3 5.1 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) CtIP_N PF10482.9 EWC48974.1 - 6.8 6.8 7.9 6.7 6.8 4.0 2.7 2 1 1 3 3 2 0 Tumour-suppressor protein CtIP N-terminal domain Glutaredoxin PF00462.24 EWC48975.1 - 3.6e-14 52.7 0.0 1e-13 51.3 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin Peptidase_S49_N PF08496.10 EWC48975.1 - 0.015 15.3 0.8 0.026 14.6 0.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GST_N_3 PF13417.6 EWC48975.1 - 0.031 14.7 0.0 0.065 13.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain MAS20 PF02064.15 EWC48975.1 - 0.16 12.1 2.2 0.44 10.6 2.2 1.7 1 1 0 1 1 1 0 MAS20 protein import receptor DSBA PF01323.20 EWC48975.1 - 0.74 9.6 5.7 7.7 6.2 0.0 2.9 2 1 1 3 3 3 0 DSBA-like thioredoxin domain ORMDL PF04061.14 EWC48976.1 - 1.6e-56 189.9 3.9 1.9e-56 189.6 3.9 1.1 1 0 0 1 1 1 1 ORMDL family Med1 PF10744.9 EWC48977.1 - 1.7e-56 192.1 0.0 6.6e-56 190.1 0.0 1.8 1 1 1 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 Sod_Cu PF00080.20 EWC48978.1 - 3.8e-09 36.8 0.0 8e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF3108 PF11306.8 EWC48978.1 - 0.15 12.0 0.3 0.22 11.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Drechslerella_stenobrocha_248-DREv1/GCA_000525045.1_DREv1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Drechslerella_stenobrocha_248-DREv1/GCA_000525045.1_DREv1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Drechslerella_stenobrocha_248-DREv1/GCA_000525045.1_DREv1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Drechslerella_stenobrocha_248-DREv1/GCA_000525045.1_DREv1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 18:38:08 2019 # [ok]